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pCL-Eco Citations (145)

Originally described in: The pCL vector system: rapid production of helper-free, high-titer, recombinant retroviruses.
Naviaux RK, Costanzi E, Haas M, Verma IM J Virol. 1996 Aug . 70(8):5701-5.
PubMed

Articles Citing pCL-Eco

Articles
Genetic dissection of histone deacetylase requirement in tumor cells. Haberland M, Johnson A, Mokalled MH, Montgomery RL, Olson EN. Proc Natl Acad Sci U S A. 2009 May 12;106(19):7751-5. doi: 10.1073/pnas.0903139106. Epub 2009 Apr 29. PubMed
Generation of induced pluripotent stem cells from neural stem cells. Kim JB, Zaehres H, Arauzo-Bravo MJ, Scholer HR. Nat Protoc. 2009;4(10):1464-70. doi: 10.1038/nprot.2009.173. Epub 2009 Sep 17. PubMed
Mouse and human induced pluripotent stem cells as a source for multipotent Isl1+ cardiovascular progenitors. Moretti A, Bellin M, Jung CB, Thies TM, Takashima Y, Bernshausen A, Schiemann M, Fischer S, Moosmang S, Smith AG, Lam JT, Laugwitz KL. FASEB J. 2010 Mar;24(3):700-11. doi: 10.1096/fj.09-139477. Epub 2009 Oct 22. PubMed
Reprogramming of telomeric regions during the generation of human induced pluripotent stem cells and subsequent differentiation into fibroblast-like derivatives. Yehezkel S, Rebibo-Sabbah A, Segev Y, Tzukerman M, Shaked R, Huber I, Gepstein L, Skorecki K, Selig S. Epigenetics. 2011 Jan;6(1):63-75. doi: 10.4161/epi.6.1.13390. Epub 2011 Jan 1. PubMed
Genetic predisposition directs breast cancer phenotype by dictating progenitor cell fate. Proia TA, Keller PJ, Gupta PB, Klebba I, Jones AD, Sedic M, Gilmore H, Tung N, Naber SP, Schnitt S, Lander ES, Kuperwasser C. Cell Stem Cell. 2011 Feb 4;8(2):149-63. doi: 10.1016/j.stem.2010.12.007. PubMed
Hedgehog overexpression is associated with stromal interactions and predicts for poor outcome in breast cancer. O'Toole SA, Machalek DA, Shearer RF, Millar EK, Nair R, Schofield P, McLeod D, Cooper CL, McNeil CM, McFarland A, Nguyen A, Ormandy CJ, Qiu MR, Rabinovich B, Martelotto LG, Vu D, Hannigan GE, Musgrove EA, Christ D, Sutherland RL, Watkins DN, Swarbrick A. Cancer Res. 2011 Jun 1;71(11):4002-14. doi: 10.1158/0008-5472.CAN-10-3738. PubMed
Activation of AMP-activated protein kinase (AMPK) provides a metabolic barrier to reprogramming somatic cells into stem cells. Vazquez-Martin A, Vellon L, Quiros PM, Cufi S, Ruiz de Galarreta E, Oliveras-Ferraros C, Martin AG, Martin-Castillo B, Lopez-Otin C, Menendez JA. Cell Cycle. 2012 Mar 1;11(5):974-89. doi: 10.4161/cc.11.5.19450. Epub 2012 Mar 1. PubMed
Metformin lowers the threshold for stress-induced senescence: a role for the microRNA-200 family and miR-205. Cufi S, Vazquez-Martin A, Oliveras-Ferraros C, Quirantes R, Segura-Carretero A, Micol V, Joven J, Bosch-Barrera J, Del Barco S, Martin-Castillo B, Vellon L, Menendez JA. Cell Cycle. 2012 Mar 15;11(6):1235-46. doi: 10.4161/cc.11.6.19665. Epub 2012 Mar 15. PubMed
CD8 lineage-specific regulation of interleukin-7 receptor expression by the transcriptional repressor Gfi1. Ligons DL, Tuncer C, Linowes BA, Akcay IM, Kurtulus S, Deniz E, Atasever Arslan B, Cevik SI, Keller HR, Luckey MA, Feigenbaum L, Moroy T, Ersahin T, Atalay R, Erman B, Park JH. J Biol Chem. 2012 Oct 5;287(41):34386-99. doi: 10.1074/jbc.M112.378687. Epub 2012 Aug 3. PubMed
Multiple roles of p53-related pathways in somatic cell reprogramming and stem cell differentiation. Yi L, Lu C, Hu W, Sun Y, Levine AJ. Cancer Res. 2012 Nov 1;72(21):5635-45. doi: 10.1158/0008-5472.CAN-12-1451. Epub 2012 Sep 10. PubMed
Codon-usage-based inhibition of HIV protein synthesis by human schlafen 11. Li M, Kao E, Gao X, Sandig H, Limmer K, Pavon-Eternod M, Jones TE, Landry S, Pan T, Weitzman MD, David M. Nature. 2012 Nov 1;491(7422):125-8. doi: 10.1038/nature11433. Epub 2012 Sep 23. PubMed
Defining Akt actions in muscle differentiation. Gardner S, Anguiano M, Rotwein P. Am J Physiol Cell Physiol. 2012 Dec 15;303(12):C1292-300. doi: 10.1152/ajpcell.00259.2012. Epub 2012 Oct 17. PubMed
Reprogramming to pluripotency through a somatic stem cell intermediate. Marthaler AG, Tiemann U, Arauzo-Bravo MJ, Wu G, Zaehres H, Hyun JK, Han DW, Scholer HR, Tapia N. PLoS One. 2013 Dec 27;8(12):e85138. doi: 10.1371/journal.pone.0085138. eCollection 2013. PubMed
Direct conversion of mouse fibroblasts into induced neural stem cells. Kim SM, Flasskamp H, Hermann A, Arauzo-Bravo MJ, Lee SC, Lee SH, Seo EH, Lee SH, Storch A, Lee HT, Scholer HR, Tapia N, Han DW. Nat Protoc. 2014 Apr;9(4):871-81. doi: 10.1038/nprot.2014.056. Epub 2014 Mar 20. PubMed
Protein and nucleotide biosynthesis are coupled by a single rate-limiting enzyme, PRPS2, to drive cancer. Cunningham JT, Moreno MV, Lodi A, Ronen SM, Ruggero D. Cell. 2014 May 22;157(5):1088-103. doi: 10.1016/j.cell.2014.03.052. PubMed
PATZ1 Is a DNA Damage-Responsive Transcription Factor That Inhibits p53 Function. Keskin N, Deniz E, Eryilmaz J, Un M, Batur T, Ersahin T, Cetin Atalay R, Sakaguchi S, Ellmeier W, Erman B. Mol Cell Biol. 2015 May;35(10):1741-53. doi: 10.1128/MCB.01475-14. Epub 2015 Mar 9. PubMed
Defects in calcium homeostasis and mitochondria can be reversed in Pompe disease. Lim JA, Li L, Kakhlon O, Myerowitz R, Raben N. Autophagy. 2015;11(2):385-402. doi: 10.1080/15548627.2015.1009779. PubMed
MALT1 is required for EGFR-induced NF-kappaB activation and contributes to EGFR-driven lung cancer progression. Pan D, Jiang C, Ma Z, Blonska M, You MJ, Lin X. Oncogene. 2015 May 18. doi: 10.1038/onc.2015.146. PubMed
Aven recognition of RNA G-quadruplexes regulates translation of the mixed lineage leukemia protooncogenes. Thandapani P, Song J, Gandin V, Cai Y, Rouleau SG, Garant JM, Boisvert FM, Yu Z, Perreault JP, Topisirovic I, Richard S. Elife. 2015 Aug 12;4. doi: 10.7554/eLife.06234. PubMed
Retroviral Transduction of T Cells and T Cell Precursors. Simmons A, Alberola-Ila J. Methods Mol Biol. 2016;1323:99-108. doi: 10.1007/978-1-4939-2809-5_8. PubMed
Enhanced OCT4 transcriptional activity substitutes for exogenous SOX2 in cellular reprogramming. Marthaler AG, Adachi K, Tiemann U, Wu G, Sabour D, Velychko S, Kleiter I, Scholer HR, Tapia N. Sci Rep. 2016 Jan 14;6:19415. doi: 10.1038/srep19415. PubMed
Registered report: IDH mutation impairs histone demethylation and results in a block to cell differentiation. Richarson AD, Scott DA, Zagnitko O, Aza-Blanc P, Chang CC, Russler-Germain DA. Elife. 2016 Mar 11;5:e10860. doi: 10.7554/eLife.10860. PubMed
ESCRT Requirements for Murine Leukemia Virus Release. Bartusch C, Prange R. Viruses. 2016 Apr 18;8(4). pii: E103. doi: 10.3390/v8040103. PubMed
The mitochondrial calcium uniporter regulates breast cancer progression via HIF-1alpha. Tosatto A, Sommaggio R, Kummerow C, Bentham RB, Blacker TS, Berecz T, Duchen MR, Rosato A, Bogeski I, Szabadkai G, Rizzuto R, Mammucari C. EMBO Mol Med. 2016 May 2;8(5):569-85. doi: 10.15252/emmm.201606255. PubMed
Generation of Induced Cardiospheres via Reprogramming of Skin Fibroblasts for Myocardial Regeneration. Xu JY, Lee YK, Ran X, Liao SY, Yang J, Au KW, Lai WH, Esteban MA, Tse HF. Stem Cells. 2016 Jun 22. doi: 10.1002/stem.2438. PubMed
Zbtb1 Safeguards Genome Integrity and Prevents p53-Mediated Apoptosis in Proliferating Lymphoid Progenitors. Cao X, Lu Y, Zhang X, Kovalovsky D. J Immunol. 2016 Aug 15;197(4):1199-211. doi: 10.4049/jimmunol.1600013. Epub 2016 Jul 8. PubMed
MIR144* inhibits antimicrobial responses against Mycobacterium tuberculosis in human monocytes and macrophages by targeting the autophagy protein DRAM2. Kim JK, Lee HM, Park KS, Shin DM, Kim TS, Kim YS, Suh HW, Kim SY, Kim IS, Kim JM, Son JW, Sohn KM, Jung SS, Chung C, Han SB, Yang CS, Jo EK. Autophagy. 2016 Oct 20:1-19. doi: 10.1080/15548627.2016.1241922. PubMed
Retroviral Transduction of Helper T Cells as a Genetic Approach to Study Mechanisms Controlling their Differentiation and Function. Singh Y, Garden OA, Lang F, Cobb BS. J Vis Exp. 2016 Nov 4;(117). doi: 10.3791/54698. PubMed
TGF-beta Controls the Formation of Kidney-Resident T Cells via Promoting Effector T Cell Extravasation. Ma C, Mishra S, Demel EL, Liu Y, Zhang N. J Immunol. 2017 Jan 15;198(2):749-756. doi: 10.4049/jimmunol.1601500. Epub 2016 Nov 30. PubMed
Caspase-2-mediated cell death is required for deleting aneuploid cells. Dawar S, Lim Y, Puccini J, White M, Thomas P, Bouchier-Hayes L, Green DR, Dorstyn L, Kumar S. Oncogene. 2016 Dec 19. doi: 10.1038/onc.2016.423. PubMed
Degranulation Response in Cytotoxic Rat Lymphocytes Measured with a Novel CD107a Antibody. Sudworth A, Dai KZ, Vaage JT, Kveberg L. Front Immunol. 2016 Dec 7;7:572. doi: 10.3389/fimmu.2016.00572. eCollection 2016. PubMed
Transduction-Transplantation Mouse Model of Myeloproliferative Neoplasm. Nguyen TK, Morse SJ, Fleischman AG. J Vis Exp. 2016 Dec 22;(118). doi: 10.3791/54624. PubMed
PPAR-alpha Activation Mediates Innate Host Defense through Induction of TFEB and Lipid Catabolism. Kim YS, Lee HM, Kim JK, Yang CS, Kim TS, Jung M, Jin HS, Kim S, Jang J, Oh GT, Kim JM, Jo EK. J Immunol. 2017 Apr 15;198(8):3283-3295. doi: 10.4049/jimmunol.1601920. Epub 2017 Mar 8. PubMed
Foxp3 Reprograms T Cell Metabolism to Function in Low-Glucose, High-Lactate Environments. Angelin A, Gil-de-Gomez L, Dahiya S, Jiao J, Guo L, Levine MH, Wang Z, Quinn WJ 3rd, Kopinski PK, Wang L, Akimova T, Liu Y, Bhatti TR, Han R, Laskin BL, Baur JA, Blair IA, Wallace DC, Hancock WW, Beier UH. Cell Metab. 2017 Jun 6;25(6):1282-1293.e7. doi: 10.1016/j.cmet.2016.12.018. Epub 2017 Apr 13. PubMed
JunB is essential for IL-23-dependent pathogenicity of Th17 cells. Hasan Z, Koizumi SI, Sasaki D, Yamada H, Arakaki N, Fujihara Y, Okitsu S, Shirahata H, Ishikawa H. Nat Commun. 2017 May 30;8:15628. doi: 10.1038/ncomms15628. PubMed
Ohmyungsamycins promote antimicrobial responses through autophagy activation via AMP-activated protein kinase pathway. Kim TS, Shin YH, Lee HM, Kim JK, Choe JH, Jang JC, Um S, Jin HS, Komatsu M, Cha GH, Chae HJ, Oh DC, Jo EK. Sci Rep. 2017 Jun 13;7(1):3431. doi: 10.1038/s41598-017-03477-3. PubMed
ESRRA (estrogen-related receptor alpha) is a key coordinator of transcriptional and post-translational activation of autophagy to promote innate host defense. Kim SY, Yang CS, Lee HM, Kim JK, Kim YS, Kim YR, Kim JS, Kim TS, Yuk JM, Dufour CR, Lee SH, Kim JM, Choi HS, Giguere V, Jo EK. Autophagy. 2018;14(1):152-168. doi: 10.1080/15548627.2017.1339001. Epub 2017 Sep 1. PubMed
Cell therapy could be a potential way to improve lipoprotein lipase deficiency. Wu W, Yin Y, Zhong J, Peng Y, Li S, Zheng L, Cao H, Zhang J. Lipids Health Dis. 2017 Oct 2;16(1):189. doi: 10.1186/s12944-017-0577-4. PubMed
Clodronate Improves Survival of Transplanted Hoxb8 Myeloid Progenitors with Constitutively Active GMCSFR in Immunocompetent Mice. Lee S, Kivimae S, Szoka FC. Mol Ther Methods Clin Dev. 2017 Sep 7;7:60-73. doi: 10.1016/j.omtm.2017.08.007. eCollection 2017 Dec 15. PubMed
Epigenetic targeting of bromodomain protein BRD4 counteracts cancer cachexia and prolongs survival. Segatto M, Fittipaldi R, Pin F, Sartori R, Dae Ko K, Zare H, Fenizia C, Zanchettin G, Pierobon ES, Hatakeyama S, Sperti C, Merigliano S, Sandri M, Filippakopoulos P, Costelli P, Sartorelli V, Caretti G. Nat Commun. 2017 Nov 22;8(1):1707. doi: 10.1038/s41467-017-01645-7. PubMed
The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages. Evavold CL, Ruan J, Tan Y, Xia S, Wu H, Kagan JC. Immunity. 2018 Jan 16;48(1):35-44.e6. doi: 10.1016/j.immuni.2017.11.013. Epub 2017 Nov 28. PubMed
The miR-17/92 cluster is involved in the molecular etiology of the SCLL syndrome driven by the BCR-FGFR1 chimeric kinase. Hu T, Chong Y, Qin H, Kitamura E, Chang CS, Silva J, Ren M, Cowell JK. Oncogene. 2018 Apr;37(14):1926-1938. doi: 10.1038/s41388-017-0091-1. Epub 2018 Jan 25. PubMed
Membrane bending occurs at all stages of clathrin-coat assembly and defines endocytic dynamics. Scott BL, Sochacki KA, Low-Nam ST, Bailey EM, Luu Q, Hor A, Dickey AM, Smith S, Kerkvliet JG, Taraska JW, Hoppe AD. Nat Commun. 2018 Jan 29;9(1):419. doi: 10.1038/s41467-018-02818-8. PubMed
Copper accumulation in senescent cells: Interplay between copper transporters and impaired autophagy. Masaldan S, Clatworthy SAS, Gamell C, Smith ZM, Francis PS, Denoyer D, Meggyesy PM, Fontaine S, Cater MA. Redox Biol. 2018 Jun;16:322-331. doi: 10.1016/j.redox.2018.03.007. Epub 2018 Mar 17. PubMed
MIR142 Loss-of-Function Mutations Derepress ASH1L to Increase HOXA Gene Expression and Promote Leukemogenesis. Trissal MC, Wong TN, Yao JC, Ramaswamy R, Kuo I, Baty J, Sun Y, Jih G, Parikh N, Berrien-Elliott MM, Fehniger TA, Ley TJ, Maillard I, Reddy PR, Link DC. Cancer Res. 2018 Jul 1;78(13):3510-3521. doi: 10.1158/0008-5472.CAN-17-3592. Epub 2018 May 3. PubMed
Phosphatidylinositol-5-Phosphate 4-Kinases Regulate Cellular Lipid Metabolism By Facilitating Autophagy. Lundquist MR, Goncalves MD, Loughran RM, Possik E, Vijayaraghavan T, Yang A, Pauli C, Ravi A, Verma A, Yang Z, Johnson JL, Wong JCY, Ma Y, Hwang KS, Weinkove D, Divecha N, Asara JM, Elemento O, Rubin MA, Kimmelman AC, Pause A, Cantley LC, Emerling BM. Mol Cell. 2018 May 3;70(3):531-544.e9. doi: 10.1016/j.molcel.2018.03.037. PubMed
Telomerase reverse transcriptase coordinates with the epithelial-to-mesenchymal transition through a feedback loop to define properties of breast cancer stem cells. El-Badawy A, Ghoneim NI, Nasr MA, Elkhenany H, Ahmed TA, Ahmed SM, El-Badri N. Biol Open. 2018 Jul 25;7(7). pii: bio.034181. doi: 10.1242/bio.034181. PubMed
Generation of Induced Cardiospheres via Reprogramming of Mouse Skin Fibroblasts. Lian W, Jia Y, Li L, Huang Z, Xu J. Curr Protoc Stem Cell Biol. 2018 Aug;46(1):e59. doi: 10.1002/cpsc.59. Epub 2018 Jul 12. PubMed
An Antiviral Branch of the IL-1 Signaling Pathway Restricts Immune-Evasive Virus Replication. Orzalli MH, Smith A, Jurado KA, Iwasaki A, Garlick JA, Kagan JC. Mol Cell. 2018 Sep 6;71(5):825-840.e6. doi: 10.1016/j.molcel.2018.07.009. Epub 2018 Aug 9. PubMed
Efficient CRISPR/Cas9-Mediated Mutagenesis in Primary Murine T Lymphocytes. Huang B, Johansen KH, Schwartzberg PL. Curr Protoc Immunol. 2019 Feb;124(1):e62. doi: 10.1002/cpim.62. Epub 2018 Oct 12. PubMed
Genome-wide analyses reveal the IRE1a-XBP1 pathway promotes T helper cell differentiation by resolving secretory stress and accelerating proliferation. Pramanik J, Chen X, Kar G, Henriksson J, Gomes T, Park JE, Natarajan K, Meyer KB, Miao Z, McKenzie ANJ, Mahata B, Teichmann SA. Genome Med. 2018 Oct 24;10(1):76. doi: 10.1186/s13073-018-0589-3. PubMed
The deubiquitinase MYSM1 dampens NOD2-mediated inflammation and tissue damage by inactivating the RIP2 complex. Panda S, Gekara NO. Nat Commun. 2018 Nov 7;9(1):4654. doi: 10.1038/s41467-018-07016-0. PubMed
Detecting Cellular Senescence in Reprogramming. Cazin C, von Joest M, Li H. Methods Mol Biol. 2019;1896:1-10. doi: 10.1007/978-1-4939-8931-7_1. PubMed
The HDAC-Associated Sin3B Protein Represses DREAM Complex Targets and Cooperates with APC/C to Promote Quiescence. Bainor AJ, Saini S, Calderon A, Casado-Polanco R, Giner-Ramirez B, Moncada C, Cantor DJ, Ernlund A, Litovchick L, David G. Cell Rep. 2018 Dec 4;25(10):2797-2807.e8. doi: 10.1016/j.celrep.2018.11.024. PubMed
Metabolic Imaging Reveals a Unique Preference of Symmetric Cell Division and Homing of Leukemia-Initiating Cells in an Endosteal Niche. Hao X, Gu H, Chen C, Huang D, Zhao Y, Xie L, Zou Y, Shu HS, Zhang Y, He X, Lai X, Zhang X, Zhou BO, Zhang CC, Chen GQ, Yu Z, Yang Y, Zheng J. Cell Metab. 2019 Apr 2;29(4):950-965.e6. doi: 10.1016/j.cmet.2018.11.013. Epub 2018 Dec 20. PubMed
REV-ERBalpha Regulates TH17 Cell Development and Autoimmunity. Amir M, Chaudhari S, Wang R, Campbell S, Mosure SA, Chopp LB, Lu Q, Shang J, Pelletier OB, He Y, Doebelin C, Cameron MD, Kojetin DJ, Kamenecka TM, Solt LA. Cell Rep. 2018 Dec 26;25(13):3733-3749.e8. doi: 10.1016/j.celrep.2018.11.101. PubMed
Genome-wide CRISPR Screens in T Helper Cells Reveal Pervasive Crosstalk between Activation and Differentiation. Henriksson J, Chen X, Gomes T, Ullah U, Meyer KB, Miragaia R, Duddy G, Pramanik J, Yusa K, Lahesmaa R, Teichmann SA. Cell. 2019 Jan 7. pii: S0092-8674(18)31569-1. doi: 10.1016/j.cell.2018.11.044. PubMed

Associated Plasmids

SIRT3 promotes antimycobacterial defenses by coordinating mitochondrial and autophagic functions. Kim TS, Jin YB, Kim YS, Kim S, Kim JK, Lee HM, Suh HW, Choe JH, Kim YJ, Koo BS, Kim HN, Jung M, Lee SH, Kim DK, Chung C, Son JW, Min JJ, Kim JM, Deng CX, Kim HS, Lee SR, Jo EK. Autophagy. 2019 Aug;15(8):1356-1375. doi: 10.1080/15548627.2019.1582743. Epub 2019 Mar 4. PubMed
Phosphoinositide Interactions Position cGAS at the Plasma Membrane to Ensure Efficient Distinction between Self- and Viral DNA. Barnett KC, Coronas-Serna JM, Zhou W, Ernandes MJ, Cao A, Kranzusch PJ, Kagan JC. Cell. 2019 Mar 7;176(6):1432-1446.e11. doi: 10.1016/j.cell.2019.01.049. Epub 2019 Feb 28. PubMed

Associated Plasmids

Innate Immune Signaling Organelles Display Natural and Programmable Signaling Flexibility. Tan Y, Kagan JC. Cell. 2019 Apr 4;177(2):384-398.e11. doi: 10.1016/j.cell.2019.01.039. Epub 2019 Mar 7. PubMed

Associated Plasmids

Generation of the human induced pluripotent stem cell (hiPSC) line PSMi007-A from a Long QT Syndrome type 1 patient carrier of two common variants in the NOS1AP gene. Mura M, Pisano F, Stefanello M, Ginevrino M, Boni M, Calabro F, Crotti L, Valente EM, Schwartz PJ, Brink PA, Gnecchi M. Stem Cell Res. 2019 Apr;36:101416. doi: 10.1016/j.scr.2019.101416. Epub 2019 Mar 6. PubMed
Lung cancer deficient in the tumor suppressor GATA4 is sensitive to TGFBR1 inhibition. Gao L, Hu Y, Tian Y, Fan Z, Wang K, Li H, Zhou Q, Zeng G, Hu X, Yu L, Zhou S, Tong X, Huang H, Chen H, Liu Q, Liu W, Zhang G, Zeng M, Zhou G, He Q, Ji H, Chen L. Nat Commun. 2019 Apr 10;10(1):1665. doi: 10.1038/s41467-019-09295-7. PubMed
Generation of the human induced pluripotent stem cell (hiPSC) line PSMi004-A from a carrier of the KCNQ1-R594Q mutation. Mura M, Lee YK, Pisano F, Ginevrino M, Boni M, Calabro F, Crotti L, Valente EM, Schwartz PJ, Tse HF, Gnecchi M. Stem Cell Res. 2019 May;37:101431. doi: 10.1016/j.scr.2019.101431. Epub 2019 Mar 27. PubMed
An effective mouse model for adoptive cancer immunotherapy targeting neoantigens. Hanada KI, Yu Z, Chappell GR, Park AS, Restifo NP. JCI Insight. 2019 May 16;4(10). pii: 124405. doi: 10.1172/jci.insight.124405. eCollection 2019 May 16. PubMed
bHLH Transcription Factor Math6 Antagonizes TGF-beta Signalling in Reprogramming, Pluripotency and Early Cell Fate Decisions. Divvela SSK, Nell P, Napirei M, Zaehres H, Chen J, Gerding WM, Nguyen HP, Gao S, Brand-Saberi B. Cells. 2019 Jun 2;8(6). pii: cells8060529. doi: 10.3390/cells8060529. PubMed
TCF1 and LEF1 Control Treg Competitive Survival and Tfr Development to Prevent Autoimmune Diseases. Yang BH, Wang K, Wan S, Liang Y, Yuan X, Dong Y, Cho S, Xu W, Jepsen K, Feng GS, Lu LF, Xue HH, Fu W. Cell Rep. 2019 Jun 18;27(12):3629-3645.e6. doi: 10.1016/j.celrep.2019.05.061. PubMed
Acetylation of BMAL1 by TIP60 controls BRD4-P-TEFb recruitment to circadian promoters. Petkau N, Budak H, Zhou X, Oster H, Eichele G. Elife. 2019 Jul 11;8. pii: 43235. doi: 10.7554/eLife.43235. PubMed
P11 Loss-of-Function is Associated with Decreased Cell Proliferation and Neurobehavioral Disorders in Mice. Liu G, Wang Y, Zheng W, Cheng H, Zhou R. Int J Biol Sci. 2019 May 20;15(7):1383-1395. doi: 10.7150/ijbs.33773. eCollection 2019. PubMed
Generation of Induced Pluripotent Cancer Cells from Glioblastoma Multiform Cell Lines. Vatanmakanian M, Yousefi H, Mashouri L, Aref AR, Khamisipour G, Bitaraf A, Alizadeh S. Cell Reprogram. 2019 Oct;21(5):238-248. doi: 10.1089/cell.2019.0046. Epub 2019 Aug 1. PubMed
A human immune dysregulation syndrome characterized by severe hyperinflammation with a homozygous nonsense Roquin-1 mutation. Tavernier SJ, Athanasopoulos V, Verloo P, Behrens G, Staal J, Bogaert DJ, Naesens L, De Bruyne M, Van Gassen S, Parthoens E, Ellyard J, Cappello J, Morris LX, Van Gorp H, Van Isterdael G, Saeys Y, Lamkanfi M, Schelstraete P, Dehoorne J, Bordon V, Van Coster R, Lambrecht BN, Menten B, Beyaert R, Vinuesa CG, Heissmeyer V, Dullaers M, Haerynck F. Nat Commun. 2019 Oct 21;10(1):4779. doi: 10.1038/s41467-019-12704-6. PubMed
Visualizing locus-specific sister chromatid exchange reveals differential patterns of replication stress-induced fragile site breakage. Waisertreiger I, Popovich K, Block M, Anderson KR, Barlow JH. Oncogene. 2020 Feb;39(6):1260-1272. doi: 10.1038/s41388-019-1054-5. Epub 2019 Oct 21. PubMed
53BP1 Enforces Distinct Pre- and Post-resection Blocks on Homologous Recombination. Callen E, Zong D, Wu W, Wong N, Stanlie A, Ishikawa M, Pavani R, Dumitrache LC, Byrum AK, Mendez-Dorantes C, Martinez P, Canela A, Maman Y, Day A, Kruhlak MJ, Blasco MA, Stark JM, Mosammaparast N, McKinnon PJ, Nussenzweig A. Mol Cell. 2020 Jan 2;77(1):26-38.e7. doi: 10.1016/j.molcel.2019.09.024. Epub 2019 Oct 22. PubMed
CRISPR/Cas9 Gene Targeting in Primary Mouse Bone Marrow-Derived Macrophages. Bailis W. Methods Mol Biol. 2020;2097:223-230. doi: 10.1007/978-1-0716-0203-4_14. PubMed
Integrated transcriptomic and epigenetic data analysis identifiesaberrant expression of genes in acute myeloid leukemia with MLLAF9 translocation. Wang F, Li Z, Wang G, Tian X, Zhou J, Yu W, Fan Z, Dong L, Lu J, Xu J, Zhang W, Liang A. Mol Med Rep. 2020 Feb;21(2):883-893. doi: 10.3892/mmr.2019.10849. Epub 2019 Nov 26. PubMed
53BP1/RIF1 signaling promotes cell survival after multifractionated radiotherapy. Eke I, Zong D, Aryankalayil MJ, Sandfort V, Bylicky MA, Rath BH, Graves EE, Nussenzweig A, Coleman CN. Nucleic Acids Res. 2020 Feb 20;48(3):1314-1326. doi: 10.1093/nar/gkz1139. PubMed
Targeting REGNASE-1 programs long-lived effector T cells for cancer therapy. Wei J, Long L, Zheng W, Dhungana Y, Lim SA, Guy C, Wang Y, Wang YD, Qian C, Xu B, Kc A, Saravia J, Huang H, Yu J, Doench JG, Geiger TL, Chi H. Nature. 2019 Dec;576(7787):471-476. doi: 10.1038/s41586-019-1821-z. Epub 2019 Dec 11. PubMed
miR-155 Overexpression in OT-1 CD8(+) T Cells Improves Anti-Tumor Activity against Low-Affinity Tumor Antigen. Monnot GC, Martinez-Usatorre A, Lanitis E, Lopes SF, Cheng WC, Ho PC, Irving M, Coukos G, Donda A, Romero P. Mol Ther Oncolytics. 2019 Dec 25;16:111-123. doi: 10.1016/j.omto.2019.12.008. eCollection 2020 Mar 27. PubMed
Sterile alpha-motif domain requirement for cellular signaling and survival. Ray S, Chee L, Matson DR, Palermo NY, Bresnick EH, Hewitt KJ. J Biol Chem. 2020 May 15;295(20):7113-7125. doi: 10.1074/jbc.RA119.011895. Epub 2020 Apr 2. PubMed
Multiplex T Cell Stimulation Assay Utilizing a T Cell Activation Reporter-Based Detection System. Mann SE, Zhou Z, Landry LG, Anderson AM, Alkanani AK, Fischer J, Peakman M, Mallone R, Campbell K, Michels AW, Nakayama M. Front Immunol. 2020 Apr 9;11:633. doi: 10.3389/fimmu.2020.00633. eCollection 2020. PubMed

Associated Plasmids

Phase and context shape the function of composite oncogenic mutations. Gorelick AN, Sanchez-Rivera FJ, Cai Y, Bielski CM, Biederstedt E, Jonsson P, Richards AL, Vasan N, Penson AV, Friedman ND, Ho YJ, Baslan T, Bandlamudi C, Scaltriti M, Schultz N, Lowe SW, Reznik E, Taylor BS. Nature. 2020 Jun;582(7810):100-103. doi: 10.1038/s41586-020-2315-8. Epub 2020 May 27. PubMed
A Genome-wide CRISPR Screen Reveals a Role for the Non-canonical Nucleosome-Remodeling BAF Complex in Foxp3 Expression and Regulatory T Cell Function. Loo CS, Gatchalian J, Liang Y, Leblanc M, Xie M, Ho J, Venkatraghavan B, Hargreaves DC, Zheng Y. Immunity. 2020 Jul 14;53(1):143-157.e8. doi: 10.1016/j.immuni.2020.06.011. Epub 2020 Jul 7. PubMed
Impaired mitochondrial oxidative phosphorylation limits the self-renewal of T cells exposed to persistent antigen. Vardhana SA, Hwee MA, Berisa M, Wells DK, Yost KE, King B, Smith M, Herrera PS, Chang HY, Satpathy AT, van den Brink MRM, Cross JR, Thompson CB. Nat Immunol. 2020 Sep;21(9):1022-1033. doi: 10.1038/s41590-020-0725-2. Epub 2020 Jul 13. PubMed
Altered 3D chromatin structure permits inversional recombination at the IgH locus. Qiu X, Ma F, Zhao M, Cao Y, Shipp L, Liu A, Dutta A, Singh A, Braikia FZ, De S, Wood WH 3rd, Becker KG, Zhou W, Ji H, Zhao K, Atchison ML, Sen R. Sci Adv. 2020 Aug 14;6(33):eaaz8850. doi: 10.1126/sciadv.aaz8850. eCollection 2020 Aug. PubMed
Potential lung attack and lethality generated by EpCAM-specific CAR-T cells in immunocompetent mouse models. Qin D, Li D, Zhang B, Chen Y, Liao X, Li X, Alexander PB, Wang Y, Li QJ. Oncoimmunology. 2020 Aug 15;9(1):1806009. doi: 10.1080/2162402X.2020.1806009. PubMed
TGFbetaR-SMAD3 Signaling Induces Resistance to PARP Inhibitors in the Bone Marrow Microenvironment. Le BV, Podszywalow-Bartnicka P, Maifrede S, Sullivan-Reed K, Nieborowska-Skorska M, Golovine K, Yao JC, Nejati R, Cai KQ, Caruso LB, Swatler J, Dabrowski M, Lian Z, Valent P, Paietta EM, Levine RL, Fernandez HF, Tallman MS, Litzow MR, Huang J, Challen GA, Link D, Tempera I, Wasik MA, Piwocka K, Skorski T. Cell Rep. 2020 Oct 6;33(1):108221. doi: 10.1016/j.celrep.2020.108221. PubMed
ESRRA (estrogen related receptor alpha) is a critical regulator of intestinal homeostasis through activation of autophagic flux via gut microbiota. Kim S, Lee JY, Shin SG, Kim JK, Silwal P, Kim YJ, Shin NR, Kim PS, Won M, Lee SH, Kim SY, Sasai M, Yamamoto M, Kim JM, Bae JW, Jo EK. Autophagy. 2021 Oct;17(10):2856-2875. doi: 10.1080/15548627.2020.1847460. Epub 2020 Dec 15. PubMed
MFSD12 mediates the import of cysteine into melanosomes and lysosomes. Adelmann CH, Traunbauer AK, Chen B, Condon KJ, Chan SH, Kunchok T, Lewis CA, Sabatini DM. Nature. 2020 Nov 18. pii: 10.1038/s41586-020-2937-x. doi: 10.1038/s41586-020-2937-x. PubMed

Associated Plasmids

The TGF-beta superfamily cytokine Activin-A is induced during autoimmune neuroinflammation and drives pathogenic Th17 cell differentiation. Wu B, Zhang S, Guo Z, Bi Y, Zhou M, Li P, Seyedsadr M, Xu X, Li JL, Markovic-Plese S, Wan YY. Immunity. 2021 Feb 9;54(2):308-323.e6. doi: 10.1016/j.immuni.2020.12.010. Epub 2021 Jan 8. PubMed
ATF3 downmodulates its new targets IFI6 and IFI27 to suppress the growth and migration of tongue squamous cell carcinoma cells. Xu L, Zu T, Li T, Li M, Mi J, Bai F, Liu G, Wen J, Li H, Brakebusch C, Wang X, Wu X. PLoS Genet. 2021 Feb 4;17(2):e1009283. doi: 10.1371/journal.pgen.1009283. eCollection 2021 Feb. PubMed
Modified Hypoxia-Inducible Factor Expression in CD8(+) T Cells Increases Antitumor Efficacy. Velica P, Cunha PP, Vojnovic N, Foskolou IP, Bargiela D, Gojkovic M, Rundqvist H, Johnson RS. Cancer Immunol Res. 2021 Apr;9(4):401-414. doi: 10.1158/2326-6066.CIR-20-0561. Epub 2021 Feb 18. PubMed
TRIM28 Expression on Dendritic Cells Prevents Excessive T Cell Priming by Silencing Endogenous Retrovirus. Chikuma S, Yamanaka S, Nakagawa S, Ueda MT, Hayabuchi H, Tokifuji Y, Kanayama M, Okamura T, Arase H, Yoshimura A. J Immunol. 2021 Apr 1;206(7):1528-1539. doi: 10.4049/jimmunol.2001003. Epub 2021 Feb 22. PubMed
Protocol to produce high-titer retrovirus for transduction of mouse bone marrow cells. Qu J, Yang Z. STAR Protoc. 2021 Apr 7;2(2):100459. doi: 10.1016/j.xpro.2021.100459. eCollection 2021 Jun 18. PubMed
Targeting Triple-Negative Breast Cancer with Combination Therapy of EGFR CAR T Cells and CDK7 Inhibition. Xia L, Zheng Z, Liu JY, Chen YJ, Ding J, Hu GS, Hu YH, Liu S, Luo WX, Xia NS, Liu W. Cancer Immunol Res. 2021 Jun;9(6):707-722. doi: 10.1158/2326-6066.CIR-20-0405. Epub 2021 Apr 19. PubMed
PD-1 suppresses TCR-CD8 cooperativity during T-cell antigen recognition. Li K, Yuan Z, Lyu J, Ahn E, Davis SJ, Ahmed R, Zhu C. Nat Commun. 2021 May 12;12(1):2746. doi: 10.1038/s41467-021-22965-9. PubMed
PI5P4Ks drive metabolic homeostasis through peroxisome-mitochondria interplay. Ravi A, Palamiuc L, Loughran RM, Triscott J, Arora GK, Kumar A, Tieu V, Pauli C, Reist M, Lew RJ, Houlihan SL, Fellmann C, Metallo C, Rubin MA, Emerling BM. Dev Cell. 2021 Jun 7;56(11):1661-1676.e10. doi: 10.1016/j.devcel.2021.04.019. Epub 2021 May 12. PubMed
The Lysine Methylase SMYD3 Modulates Mesendodermal Commitment during Development. Fittipaldi R, Floris P, Proserpio V, Cotelli F, Beltrame M, Caretti G. Cells. 2021 May 18;10(5). pii: cells10051233. doi: 10.3390/cells10051233. PubMed
Mammalian cells use the autophagy process to restrict avian influenza virus replication. Liu S, Mok BW, Deng S, Liu H, Wang P, Song W, Chen P, Huang X, Zheng M, Lau SY, Cremin CJ, Tam CY, Li B, Jiang L, Chen Y, Yuen KY, Chen H. Cell Rep. 2021 Jun 8;35(10):109213. doi: 10.1016/j.celrep.2021.109213. PubMed
Expanding the Differentiation Potential of Already-Established Pluripotent Stem Cells. Gonzalez-Martinez J, Malumbres M. Methods Mol Biol. 2021 Jun 15. doi: 10.1007/7651_2021_408. PubMed
ULK1 inhibition overcomes compromised antigen presentation and restores antitumor immunity in LKB1 mutant lung cancer. Deng J, Thennavan A, Dolgalev I, Chen T, Li J, Marzio A, Poirier JT, Peng D, Bulatovic M, Mukhopadhyay S, Silver H, Papadopoulos E, Pyon V, Thakurdin C, Han H, Li F, Li S, Ding H, Hu H, Pan Y, Weerasekara V, Jiang B, Wang ES, Ahearn I, Philips M, Papagiannakopoulos T, Tsirigos A, Rothenberg E, Gainor J, Freeman GJ, Rudin CM, Gray NS, Hammerman PS, Pagano M, Heymach JV, Perou CM, Bardeesy N, Wong KK. Nat Cancer. 2021 May;2(5):503-514. doi: 10.1038/s43018-021-00208-6. Epub 2021 May 17. PubMed
Revealing molecular pathways for cancer cell fitness through a genetic screen of the cancer translatome. Kuzuoglu-Ozturk D, Hu Z, Rama M, Devericks E, Weiss J, Chiang GG, Worland ST, Brenner SE, Goodarzi H, Gilbert LA, Ruggero D. Cell Rep. 2021 Jun 29;35(13):109321. doi: 10.1016/j.celrep.2021.109321. PubMed
TET2 and DNMT3A Mutations Exert Divergent Effects on DNA Repair and Sensitivity of Leukemia Cells to PARP Inhibitors. Maifrede S, Le BV, Nieborowska-Skorska M, Golovine K, Sullivan-Reed K, Dunuwille WMB, Nacson J, Hulse M, Keith K, Madzo J, Caruso LB, Gazze Z, Lian Z, Padella A, Chitrala KN, Bartholdy BA, Matlawska-Wasowska K, Di Marcantonio D, Simonetti G, Greiner G, Sykes SM, Valent P, Paietta EM, Tallman MS, Fernandez HF, Litzow MR, Minden MD, Huang J, Martinelli G, Vassiliou GS, Tempera I, Piwocka K, Johnson N, Challen GA, Skorski T. Cancer Res. 2021 Oct 1;81(19):5089-5101. doi: 10.1158/0008-5472.CAN-20-3761. Epub 2021 Jul 2. PubMed
Nuclear NAD(+) homeostasis governed by NMNAT1 prevents apoptosis of acute myeloid leukemia stem cells. Shi X, Jiang Y, Kitano A, Hu T, Murdaugh RL, Li Y, Hoegenauer KA, Chen R, Takahashi K, Nakada D. Sci Adv. 2021 Jul 21;7(30). pii: 7/30/eabf3895. doi: 10.1126/sciadv.abf3895. Print 2021 Jul. PubMed
Synthetic essentiality between PTEN and core dependency factor PAX7 dictates rhabdomyosarcoma identity. Langdon CG, Gadek KE, Garcia MR, Evans MK, Reed KB, Bush M, Hanna JA, Drummond CJ, Maguire MC, Leavey PJ, Finkelstein D, Jin H, Schreiner PA, Rehg JE, Hatley ME. Nat Commun. 2021 Sep 17;12(1):5520. doi: 10.1038/s41467-021-25829-4. PubMed
Perturbation-Based Modeling Unveils the Autophagic Modulation of Chemosensitivity and Immunogenicity in Breast Cancer Cells. Quiros-Fernandez I, Figueroa-Protti L, Arias-Arias JL, Brenes-Cordero N, Siles F, Mora J, Mora-Rodriguez RA. Metabolites. 2021 Sep 18;11(9). pii: metabo11090637. doi: 10.3390/metabo11090637. PubMed
Cancer-associated mutations in VAV1 trigger variegated signaling outputs and T-cell lymphomagenesis. Robles-Valero J, Fernandez-Nevado L, Lorenzo-Martin LF, Cuadrado M, Fernandez-Pisonero I, Rodriguez-Fdez S, Astorga-Simon EN, Abad A, Caloto R, Bustelo XR. EMBO J. 2021 Nov 15;40(22):e108125. doi: 10.15252/embj.2021108125. Epub 2021 Oct 7. PubMed
Nano-optogenetic engineering of CAR T cells for precision immunotherapy with enhanced safety. Nguyen NT, Huang K, Zeng H, Jing J, Wang R, Fang S, Chen J, Liu X, Huang Z, You MJ, Rao A, Huang Y, Han G, Zhou Y. Nat Nanotechnol. 2021 Dec;16(12):1424-1434. doi: 10.1038/s41565-021-00982-5. Epub 2021 Oct 25. PubMed
CRISPR screens unveil signal hubs for nutrient licensing of T cell immunity. Long L, Wei J, Lim SA, Raynor JL, Shi H, Connelly JP, Wang H, Guy C, Xie B, Chapman NM, Fu G, Wang Y, Huang H, Su W, Saravia J, Risch I, Wang YD, Li Y, Niu M, Dhungana Y, Kc A, Zhou P, Vogel P, Yu J, Pruett-Miller SM, Peng J, Chi H. Nature. 2021 Dec;600(7888):308-313. doi: 10.1038/s41586-021-04109-7. Epub 2021 Nov 18. PubMed
Disrupting Roquin-1 interaction with Regnase-1 induces autoimmunity and enhances antitumor responses. Behrens G, Edelmann SL, Raj T, Kronbeck N, Monecke T, Davydova E, Wong EH, Kifinger L, Giesert F, Kirmaier ME, Hohn C, de Jonge LS, Pisfil MG, Fu M, Theurich S, Feske S, Kawakami N, Wurst W, Niessing D, Heissmeyer V. Nat Immunol. 2021 Dec;22(12):1563-1576. doi: 10.1038/s41590-021-01064-3. Epub 2021 Nov 22. PubMed
High Metabolic Dependence on Oxidative Phosphorylation Drives Sensitivity to Metformin Treatment in MLL/AF9 Acute Myeloid Leukemia. Liu L, Patnana PK, Xie X, Frank D, Nimmagadda SC, Rosemann A, Liebmann M, Klotz L, Opalka B, Khandanpour C. Cancers (Basel). 2022 Jan 19;14(3). pii: cancers14030486. doi: 10.3390/cancers14030486. PubMed
A clinically compatible drug-screening platform based on organotypic cultures identifies vulnerabilities to prevent and treat brain metastasis. Zhu L, Retana D, Garcia-Gomez P, Alvaro-Espinosa L, Priego N, Masmudi-Martin M, Yebra N, Miarka L, Hernandez-Encinas E, Blanco-Aparicio C, Martinez S, Sobrino C, Ajenjo N, Artiga MJ, Ortega-Paino E, Torres-Ruiz R, Rodriguez-Perales S, Soffietti R, Bertero L, Cassoni P, Weiss T, Munoz J, Sepulveda JM, Gonzalez-Leon P, Jimenez-Roldan L, Moreno LM, Esteban O, Perez-Nunez A, Hernandez-Lain A, Toldos O, Ruano Y, Alcazar L, Blasco G, Fernandez-Alen J, Caleiras E, Lafarga M, Megias D, Grana-Castro O, Nor C, Taylor MD, Young LS, Vareslija D, Cosgrove N, Couch FJ, Cusso L, Desco M, Mouron S, Quintela-Fandino M, Weller M, Pastor J, Valiente M. EMBO Mol Med. 2022 Mar 7;14(3):e14552. doi: 10.15252/emmm.202114552. Epub 2022 Feb 17. PubMed
Gilteritinib enhances graft-versus-leukemia effects against FLT3-ITD mutant leukemia after allogeneic hematopoietic stem cell transplantation. Zhang Z, Hasegawa Y, Hashimoto D, Senjo H, Kikuchi R, Chen X, Yoneda K, Sekiguchi T, Kawase T, Tsuzuki H, Ishio T, Ara T, Ohigashi H, Nakagawa M, Teshima T. Bone Marrow Transplant. 2022 May;57(5):775-780. doi: 10.1038/s41409-022-01619-4. Epub 2022 Feb 28. PubMed
Novel Role of Prereplication Complex Component Cell Division Cycle 6 in Retinal Neovascularization. Kumar R, Rao GN. Arterioscler Thromb Vasc Biol. 2022 Apr;42(4):407-427. doi: 10.1161/ATVBAHA.121.317182. Epub 2022 Mar 3. PubMed
The KRAS-G12D mutation induces metabolic vulnerability in B-cell acute lymphoblastic leukemia. Xu Y, Fang H, Chen Y, Tang Y, Sun H, Kong Z, Yang F, Kirschner-Schwabe R, Zhu L, Toker A, Xiao N, Zhou BS, Li H. iScience. 2022 Feb 7;25(3):103881. doi: 10.1016/j.isci.2022.103881. eCollection 2022 Mar 18. PubMed
Vitamin B6 Metabolism Determines T Cell Anti-Tumor Responses. Bargiela D, Cunha PP, Velica P, Foskolou IP, Barbieri L, Rundqvist H, Johnson RS. Front Immunol. 2022 Feb 17;13:837669. doi: 10.3389/fimmu.2022.837669. eCollection 2022. PubMed
A saturation-mutagenesis analysis of the interplay between stability and activation in Ras. Hidalgo F, Nocka LM, Shah NH, Gorday K, Latorraca NR, Bandaru P, Templeton S, Lee D, Karandur D, Pelton JG, Marqusee S, Wemmer D, Kuriyan J. Elife. 2022 Mar 11;11. pii: 76595. doi: 10.7554/eLife.76595. PubMed
Chemical modulation of SQSTM1/p62-mediated xenophagy that targets a broad range of pathogenic bacteria. Lee YJ, Kim JK, Jung CH, Kim YJ, Jung EJ, Lee SH, Choi HR, Son YS, Shim SM, Jeon SM, Choe JH, Lee SH, Whang J, Sohn KC, Hur GM, Kim HT, Yeom J, Jo EK, Kwon YT. Autophagy. 2022 Apr 5:1-20. doi: 10.1080/15548627.2022.2054240. PubMed
Scinderin promotes fusion of electron transport chain dysfunctional muscle stem cells with myofibers. Wang X, Shelton SD, Bordieanu B, Frank AR, Yi Y, Venigalla SSK, Gu Z, Lenser NP, Glogauer M, Chandel NS, Zhao H, Zhao Z, McFadden DG, Mishra P. Nat Aging. 2022;2(2):155-169. doi: 10.1038/s43587-021-00164-x. Epub 2022 Jan 27. PubMed
CAR T cells expressing a bacterial virulence factor trigger potent bystander antitumour responses in solid cancers. Jin C, Ma J, Ramachandran M, Yu D, Essand M. Nat Biomed Eng. 2022 Jul;6(7):830-841. doi: 10.1038/s41551-022-00875-5. Epub 2022 Apr 4. PubMed
T Cell-Mediated Targeted Delivery of Anti-PD-L1 Nanobody Overcomes Poor Antibody Penetration and Improves PD-L1 Blocking at the Tumor Site. Petit PF, Bombart R, Desimpel PH, Naulaerts S, Thouvenel L, Collet JF, Van den Eynde BJ, Zhu J. Cancer Immunol Res. 2022 Jun 3;10(6):713-727. doi: 10.1158/2326-6066.CIR-21-0801. PubMed
Mapping the cardiac vascular niche in heart failure. Peisker F, Halder M, Nagai J, Ziegler S, Kaesler N, Hoeft K, Li R, Bindels EMJ, Kuppe C, Moellmann J, Lehrke M, Stoppe C, Schaub MT, Schneider RK, Costa I, Kramann R. Nat Commun. 2022 May 31;13(1):3027. doi: 10.1038/s41467-022-30682-0. PubMed
Superkine IL-2 and IL-33 Armored CAR T Cells Reshape the Tumor Microenvironment and Reduce Growth of Multiple Solid Tumors. Brog RA, Ferry SL, Schiebout CT, Messier CM, Cook WJ, Abdullah L, Zou J, Kumar P, Sentman CL, Frost HR, Huang YH. Cancer Immunol Res. 2022 Aug 3;10(8):962-977. doi: 10.1158/2326-6066.CIR-21-0536. PubMed
Functional requirements for a Samd14-capping protein complex in stress erythropoiesis. Ray S, Chee L, Zhou Y, Schaefer MA, Naldrett MJ, Alvarez S, Woods NT, Hewitt KJ. Elife. 2022 Jun 17;11:e76497. doi: 10.7554/eLife.76497. PubMed
Host B cells escape CAR-T immunotherapy by reversible downregulation of CD19. Fioretti S, Matson CA, Rosenberg KM, Singh NJ. Cancer Immunol Immunother. 2022 Jun 26. pii: 10.1007/s00262-022-03231-3. doi: 10.1007/s00262-022-03231-3. PubMed
Generation of hematopoietic lineage cell-specific chimeric mice using retrovirus-transduced fetal liver cells. Hong H, Lee Y. STAR Protoc. 2022 Sep 16;3(3):101526. doi: 10.1016/j.xpro.2022.101526. Epub 2022 Jul 1. PubMed
In vivo genome-wide CRISPR screening in murine acute myeloid leukemia uncovers microenvironmental dependencies. Mercier FE, Shi J, Sykes DB, Oki T, Jankovic M, Man CH, Kfoury YS, Miller E, He S, Zhu A, Vasic R, Doench J, Orthwein A, Michor F, Scadden DT. Blood Adv. 2022 Sep 13;6(17):5072-5084. doi: 10.1182/bloodadvances.2022007250. PubMed
Establishment and characterization of IPS-OGC-C1: a novel induced pluripotent stem cell line from healthy human ovarian granulosa cells. Wang Z, Hu X, He Q, Lai J, Pan R, Zheng J, Chen Y. Hum Cell. 2022 Sep;35(5):1612-1620. doi: 10.1007/s13577-022-00757-7. Epub 2022 Jul 25. PubMed
The function of Wtap in N(6)-adenosine methylation of mRNAs controls T cell receptor signaling and survival of T cells. Ito-Kureha T, Leoni C, Borland K, Cantini G, Bataclan M, Metzger RN, Ammann G, Krug AB, Marsico A, Kaiser S, Canzar S, Feske S, Monticelli S, Konig J, Heissmeyer V. Nat Immunol. 2022 Aug;23(8):1208-1221. doi: 10.1038/s41590-022-01268-1. Epub 2022 Jul 25. PubMed
METTL14-dependent m(6)A modification controls iNKT cell development and function. Cao L, Morgun E, Genardi S, Visvabharathy L, Cui Y, Huang H, Wang CR. Cell Rep. 2022 Aug 2;40(5):111156. doi: 10.1016/j.celrep.2022.111156. PubMed
SUSD2 suppresses CD8(+) T cell antitumor immunity by targeting IL-2 receptor signaling. Zhao B, Gong W, Ma A, Chen J, Velegraki M, Dong H, Liu Z, Wang L, Okimoto T, Jones DM, Lei YL, Long M, Oestreich KJ, Ma Q, Xin G, Carbone DP, He K, Li Z, Wen H. Nat Immunol. 2022 Nov;23(11):1588-1599. doi: 10.1038/s41590-022-01326-8. Epub 2022 Oct 20. PubMed
The proprotein convertase furin regulates the development of thymic epithelial cells to ensure central immune tolerance. Liang Z, Zhang Z, Zhang Q, Dong X, Yang X, Zhang J, Lei T, Creemers JWM, Zhang B, Zhao Y. iScience. 2022 Sep 28;25(10):105233. doi: 10.1016/j.isci.2022.105233. eCollection 2022 Oct 21. PubMed
Fully murine CD105-targeted CAR-T cells provide an immunocompetent model for CAR-T cell biology. Lontos K, Wang Y, Colbert M, Kumar A, Joshi S, Philbin M, Wang Y, Frisch A, Lohmueller J, Rivadeneira DB, Delgoffe GM. Oncoimmunology. 2022 Oct 18;11(1):2131229. doi: 10.1080/2162402X.2022.2131229. eCollection 2022. PubMed

Associated Plasmids

Monoacylglycerol O-acyltransferase 1 lowers adipocyte differentiation capacity in vitro but does not affect adiposity in mice. Singer JM, Shew TM, Ferguson D, Renkemeyer MK, Pietka TA, Hall AM, Finck BN, Lutkewitte AJ. Obesity (Silver Spring). 2022 Nov;30(11):2122-2133. doi: 10.1002/oby.23538. PubMed
Colon tumour cell death causes mTOR dependence by paracrine P2X4 stimulation. Schmitt M, Ceteci F, Gupta J, Pesic M, Bottger TW, Nicolas AM, Kennel KB, Engel E, Schewe M, Callak Kirisozu A, Petrocelli V, Dabiri Y, Varga J, Ramakrishnan M, Karimova M, Ablasser A, Sato T, Arkan MC, de Sauvage FJ, Greten FR. Nature. 2022 Dec;612(7939):347-353. doi: 10.1038/s41586-022-05426-1. Epub 2022 Nov 16. PubMed
Heterogeneous nuclear ribonucleoprotein K is overexpressed in acute myeloid leukemia and causes myeloproliferation in mice via altered Runx1 splicing. Aitken MJL, Malaney P, Zhang X, Herbrich SM, Chan L, Benitez O, Rodriguez AG, Ma H, Jacamo R, Duan R, Link TM, Kornblau SM, Kanagal-Shamanna R, Bueso-Ramos CE, Post SM. NAR Cancer. 2022 Dec 9;4(4):zcac039. doi: 10.1093/narcan/zcac039. eCollection 2022 Dec. PubMed
Infiltration of Tumors Is Regulated by T cell-Intrinsic Nitric Oxide Synthesis. Cunha PP, Bargiela D, Minogue E, Krause LCM, Barbieri L, Brombach C, Gojkovic M, Marklund E, Pietsch S, Foskolou I, Branco CM, Velica P, Johnson RS. Cancer Immunol Res. 2023 Mar 1;11(3):351-363. doi: 10.1158/2326-6066.CIR-22-0387. PubMed
Engineering an inhibitor-resistant human CSF1R variant for microglia replacement. Chadarevian JP, Lombroso SI, Peet GC, Hasselmann J, Tu C, Marzan DE, Capocchi J, Purnell FS, Nemec KM, Lahian A, Escobar A, England W, Chaluvadi S, O'Brien CA, Yaqoob F, Aisenberg WH, Porras-Paniagua M, Bennett ML, Davtyan H, Spitale RC, Blurton-Jones M, Bennett FC. J Exp Med. 2023 Mar 6;220(3):e20220857. doi: 10.1084/jem.20220857. Epub 2022 Dec 30. PubMed
A conditional Smg6 mutant mouse model reveals circadian clock regulation through the nonsense-mediated mRNA decay pathway. Katsioudi G, Dreos R, Arpa ES, Gaspari S, Liechti A, Sato M, Gabriel CH, Kramer A, Brown SA, Gatfield D. Sci Adv. 2023 Jan 13;9(2):eade2828. doi: 10.1126/sciadv.ade2828. Epub 2023 Jan 13. PubMed
Low protease activity in B cell follicles promotes retention of intact antigens after immunization. Aung A, Cui A, Maiorino L, Amini AP, Gregory JR, Bukenya M, Zhang Y, Lee H, Cottrell CA, Morgan DM, Silva M, Suh H, Kirkpatrick JD, Amlashi P, Remba T, Froehle LM, Xiao S, Abraham W, Adams J, Love JC, Huyett P, Kwon DS, Hacohen N, Schief WR, Bhatia SN, Irvine DJ. Science. 2023 Jan 27;379(6630):eabn8934. doi: 10.1126/science.abn8934. Epub 2023 Jan 27. PubMed
Structural Basis for Self-Discrimination by Neoantigen-Specific TCRs. Finnigan J, Newman J, Patskovsky Y, Patskovska L, Ishizuka A, Lynn G, Seder R, Krogsgaard M, Bhardwaj N. Res Sq. 2023 Jan 31:rs.3.rs-2531184. doi: 10.21203/rs.3.rs-2531184/v1. Preprint. PubMed
Protocol for quantitative evaluation of the impact of paracrine senescence on cellular reprogramming in cultured cells and mouse models. Chantrel J, Chen C, Zhang J, Li H. STAR Protoc. 2023 Feb 7;4(1):102106. doi: 10.1016/j.xpro.2023.102106. PubMed
RBFOX2 modulates a metastatic signature of alternative splicing in pancreatic cancer. Jbara A, Lin KT, Stossel C, Siegfried Z, Shqerat H, Amar-Schwartz A, Elyada E, Mogilevsky M, Raitses-Gurevich M, Johnson JL, Yaron TM, Ovadia O, Jang GH, Danan-Gotthold M, Cantley LC, Levanon EY, Gallinger S, Krainer AR, Golan T, Karni R. Nature. 2023 May;617(7959):147-153. doi: 10.1038/s41586-023-05820-3. Epub 2023 Mar 22. PubMed
ABL1 kinase as a tumor suppressor in AML1-ETO and NUP98-PMX1 leukemias. Golovine K, Abalakov G, Lian Z, Chatla S, Karami A, Chitrala KN, Madzo J, Nieborowska-Skorska M, Huang J, Skorski T. Blood Cancer J. 2023 Mar 23;13(1):42. doi: 10.1038/s41408-023-00810-0. PubMed
RNA binding protein SYNCRIP maintains proteostasis and self-renewal of hematopoietic stem and progenitor cells. Herrejon Chavez F, Luo H, Cifani P, Pine A, Chu KL, Joshi S, Barin E, Schurer A, Chan M, Chang K, Han GYQ, Pierson AJ, Xiao M, Yang X, Kuehm LM, Hong Y, Nguyen DTT, Chiosis G, Kentsis A, Leslie C, Vu LP, Kharas MG. Nat Commun. 2023 Apr 21;14(1):2290. doi: 10.1038/s41467-023-38001-x. PubMed
Selection of Cell Populations with High or Low Surface Marker Expression Using Magnetic Sorting. Polyakova N, Kandarakov O, Belyavsky A. Cells. 2023 Apr 29;12(9):1286. doi: 10.3390/cells12091286. PubMed
Leishmania major drives host phagocyte death and cell-to-cell transfer depending on intracellular pathogen proliferation rate. Baars I, Jaedtka M, Dewitz LA, Fu Y, Franz T, Mohr J, Gintschel P, Berlin H, Degen A, Freier S, Rygol S, Schraven B, Kahlfuss S, van Zandbergen G, Muller AJ. JCI Insight. 2023 Jul 24;8(14):e169020. doi: 10.1172/jci.insight.169020. PubMed

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