pCL-Eco Citations (284)
Originally described in: The pCL vector system: rapid production of helper-free, high-titer, recombinant retroviruses.Naviaux RK, Costanzi E, Haas M, Verma IM J Virol. 1996 Aug . 70(8):5701-5. PubMed
Articles Citing pCL-Eco
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| Genetic dissection of histone deacetylase requirement in tumor cells. Haberland M, Johnson A, Mokalled MH, Montgomery RL, Olson EN. Proc Natl Acad Sci U S A. 2009 May 12;106(19):7751-5. doi: 10.1073/pnas.0903139106. Epub 2009 Apr 29. PubMed |
| Generation of induced pluripotent stem cells from neural stem cells. Kim JB, Zaehres H, Arauzo-Bravo MJ, Scholer HR. Nat Protoc. 2009;4(10):1464-70. doi: 10.1038/nprot.2009.173. Epub 2009 Sep 17. PubMed |
| Mouse and human induced pluripotent stem cells as a source for multipotent Isl1+ cardiovascular progenitors. Moretti A, Bellin M, Jung CB, Thies TM, Takashima Y, Bernshausen A, Schiemann M, Fischer S, Moosmang S, Smith AG, Lam JT, Laugwitz KL. FASEB J. 2010 Mar;24(3):700-11. doi: 10.1096/fj.09-139477. Epub 2009 Oct 22. PubMed |
| Reprogramming of telomeric regions during the generation of human induced pluripotent stem cells and subsequent differentiation into fibroblast-like derivatives. Yehezkel S, Rebibo-Sabbah A, Segev Y, Tzukerman M, Shaked R, Huber I, Gepstein L, Skorecki K, Selig S. Epigenetics. 2011 Jan;6(1):63-75. doi: 10.4161/epi.6.1.13390. Epub 2011 Jan 1. PubMed |
| Genetic predisposition directs breast cancer phenotype by dictating progenitor cell fate. Proia TA, Keller PJ, Gupta PB, Klebba I, Jones AD, Sedic M, Gilmore H, Tung N, Naber SP, Schnitt S, Lander ES, Kuperwasser C. Cell Stem Cell. 2011 Feb 4;8(2):149-63. doi: 10.1016/j.stem.2010.12.007. PubMed |
| Hedgehog overexpression is associated with stromal interactions and predicts for poor outcome in breast cancer. O'Toole SA, Machalek DA, Shearer RF, Millar EK, Nair R, Schofield P, McLeod D, Cooper CL, McNeil CM, McFarland A, Nguyen A, Ormandy CJ, Qiu MR, Rabinovich B, Martelotto LG, Vu D, Hannigan GE, Musgrove EA, Christ D, Sutherland RL, Watkins DN, Swarbrick A. Cancer Res. 2011 Jun 1;71(11):4002-14. doi: 10.1158/0008-5472.CAN-10-3738. PubMed |
| Activation of AMP-activated protein kinase (AMPK) provides a metabolic barrier to reprogramming somatic cells into stem cells. Vazquez-Martin A, Vellon L, Quiros PM, Cufi S, Ruiz de Galarreta E, Oliveras-Ferraros C, Martin AG, Martin-Castillo B, Lopez-Otin C, Menendez JA. Cell Cycle. 2012 Mar 1;11(5):974-89. doi: 10.4161/cc.11.5.19450. Epub 2012 Mar 1. PubMed |
| Metformin lowers the threshold for stress-induced senescence: a role for the microRNA-200 family and miR-205. Cufi S, Vazquez-Martin A, Oliveras-Ferraros C, Quirantes R, Segura-Carretero A, Micol V, Joven J, Bosch-Barrera J, Del Barco S, Martin-Castillo B, Vellon L, Menendez JA. Cell Cycle. 2012 Mar 15;11(6):1235-46. doi: 10.4161/cc.11.6.19665. Epub 2012 Mar 15. PubMed |
| CD8 lineage-specific regulation of interleukin-7 receptor expression by the transcriptional repressor Gfi1. Ligons DL, Tuncer C, Linowes BA, Akcay IM, Kurtulus S, Deniz E, Atasever Arslan B, Cevik SI, Keller HR, Luckey MA, Feigenbaum L, Moroy T, Ersahin T, Atalay R, Erman B, Park JH. J Biol Chem. 2012 Oct 5;287(41):34386-99. doi: 10.1074/jbc.M112.378687. Epub 2012 Aug 3. PubMed |
| Multiple roles of p53-related pathways in somatic cell reprogramming and stem cell differentiation. Yi L, Lu C, Hu W, Sun Y, Levine AJ. Cancer Res. 2012 Nov 1;72(21):5635-45. doi: 10.1158/0008-5472.CAN-12-1451. Epub 2012 Sep 10. PubMed |
| Codon-usage-based inhibition of HIV protein synthesis by human schlafen 11. Li M, Kao E, Gao X, Sandig H, Limmer K, Pavon-Eternod M, Jones TE, Landry S, Pan T, Weitzman MD, David M. Nature. 2012 Nov 1;491(7422):125-8. doi: 10.1038/nature11433. Epub 2012 Sep 23. PubMed |
| Defining Akt actions in muscle differentiation. Gardner S, Anguiano M, Rotwein P. Am J Physiol Cell Physiol. 2012 Dec 15;303(12):C1292-300. doi: 10.1152/ajpcell.00259.2012. Epub 2012 Oct 17. PubMed |
| Reprogramming to pluripotency through a somatic stem cell intermediate. Marthaler AG, Tiemann U, Arauzo-Bravo MJ, Wu G, Zaehres H, Hyun JK, Han DW, Scholer HR, Tapia N. PLoS One. 2013 Dec 27;8(12):e85138. doi: 10.1371/journal.pone.0085138. eCollection 2013. PubMed |
| Direct conversion of mouse fibroblasts into induced neural stem cells. Kim SM, Flasskamp H, Hermann A, Arauzo-Bravo MJ, Lee SC, Lee SH, Seo EH, Lee SH, Storch A, Lee HT, Scholer HR, Tapia N, Han DW. Nat Protoc. 2014 Apr;9(4):871-81. doi: 10.1038/nprot.2014.056. Epub 2014 Mar 20. PubMed |
| Protein and nucleotide biosynthesis are coupled by a single rate-limiting enzyme, PRPS2, to drive cancer. Cunningham JT, Moreno MV, Lodi A, Ronen SM, Ruggero D. Cell. 2014 May 22;157(5):1088-103. doi: 10.1016/j.cell.2014.03.052. PubMed |
| PATZ1 Is a DNA Damage-Responsive Transcription Factor That Inhibits p53 Function. Keskin N, Deniz E, Eryilmaz J, Un M, Batur T, Ersahin T, Cetin Atalay R, Sakaguchi S, Ellmeier W, Erman B. Mol Cell Biol. 2015 May;35(10):1741-53. doi: 10.1128/MCB.01475-14. Epub 2015 Mar 9. PubMed |
| Defects in calcium homeostasis and mitochondria can be reversed in Pompe disease. Lim JA, Li L, Kakhlon O, Myerowitz R, Raben N. Autophagy. 2015;11(2):385-402. doi: 10.1080/15548627.2015.1009779. PubMed |
| MALT1 is required for EGFR-induced NF-kappaB activation and contributes to EGFR-driven lung cancer progression. Pan D, Jiang C, Ma Z, Blonska M, You MJ, Lin X. Oncogene. 2015 May 18. doi: 10.1038/onc.2015.146. PubMed |
| Aven recognition of RNA G-quadruplexes regulates translation of the mixed lineage leukemia protooncogenes. Thandapani P, Song J, Gandin V, Cai Y, Rouleau SG, Garant JM, Boisvert FM, Yu Z, Perreault JP, Topisirovic I, Richard S. Elife. 2015 Aug 12;4. doi: 10.7554/eLife.06234. PubMed |
| Retroviral Transduction of T Cells and T Cell Precursors. Simmons A, Alberola-Ila J. Methods Mol Biol. 2016;1323:99-108. doi: 10.1007/978-1-4939-2809-5_8. PubMed |
| Enhanced OCT4 transcriptional activity substitutes for exogenous SOX2 in cellular reprogramming. Marthaler AG, Adachi K, Tiemann U, Wu G, Sabour D, Velychko S, Kleiter I, Scholer HR, Tapia N. Sci Rep. 2016 Jan 14;6:19415. doi: 10.1038/srep19415. PubMed |
| Registered report: IDH mutation impairs histone demethylation and results in a block to cell differentiation. Richarson AD, Scott DA, Zagnitko O, Aza-Blanc P, Chang CC, Russler-Germain DA. Elife. 2016 Mar 11;5:e10860. doi: 10.7554/eLife.10860. PubMed |
| ESCRT Requirements for Murine Leukemia Virus Release. Bartusch C, Prange R. Viruses. 2016 Apr 18;8(4). pii: E103. doi: 10.3390/v8040103. PubMed |
| The mitochondrial calcium uniporter regulates breast cancer progression via HIF-1alpha. Tosatto A, Sommaggio R, Kummerow C, Bentham RB, Blacker TS, Berecz T, Duchen MR, Rosato A, Bogeski I, Szabadkai G, Rizzuto R, Mammucari C. EMBO Mol Med. 2016 May 2;8(5):569-85. doi: 10.15252/emmm.201606255. PubMed |
| Generation of Induced Cardiospheres via Reprogramming of Skin Fibroblasts for Myocardial Regeneration. Xu JY, Lee YK, Ran X, Liao SY, Yang J, Au KW, Lai WH, Esteban MA, Tse HF. Stem Cells. 2016 Jun 22. doi: 10.1002/stem.2438. PubMed |
| Zbtb1 Safeguards Genome Integrity and Prevents p53-Mediated Apoptosis in Proliferating Lymphoid Progenitors. Cao X, Lu Y, Zhang X, Kovalovsky D. J Immunol. 2016 Aug 15;197(4):1199-211. doi: 10.4049/jimmunol.1600013. Epub 2016 Jul 8. PubMed |
| MIR144* inhibits antimicrobial responses against Mycobacterium tuberculosis in human monocytes and macrophages by targeting the autophagy protein DRAM2. Kim JK, Lee HM, Park KS, Shin DM, Kim TS, Kim YS, Suh HW, Kim SY, Kim IS, Kim JM, Son JW, Sohn KM, Jung SS, Chung C, Han SB, Yang CS, Jo EK. Autophagy. 2016 Oct 20:1-19. doi: 10.1080/15548627.2016.1241922. PubMed |
| Retroviral Transduction of Helper T Cells as a Genetic Approach to Study Mechanisms Controlling their Differentiation and Function. Singh Y, Garden OA, Lang F, Cobb BS. J Vis Exp. 2016 Nov 4;(117). doi: 10.3791/54698. PubMed |
| TGF-beta Controls the Formation of Kidney-Resident T Cells via Promoting Effector T Cell Extravasation. Ma C, Mishra S, Demel EL, Liu Y, Zhang N. J Immunol. 2017 Jan 15;198(2):749-756. doi: 10.4049/jimmunol.1601500. Epub 2016 Nov 30. PubMed |
| Caspase-2-mediated cell death is required for deleting aneuploid cells. Dawar S, Lim Y, Puccini J, White M, Thomas P, Bouchier-Hayes L, Green DR, Dorstyn L, Kumar S. Oncogene. 2016 Dec 19. doi: 10.1038/onc.2016.423. PubMed |
| Degranulation Response in Cytotoxic Rat Lymphocytes Measured with a Novel CD107a Antibody. Sudworth A, Dai KZ, Vaage JT, Kveberg L. Front Immunol. 2016 Dec 7;7:572. doi: 10.3389/fimmu.2016.00572. eCollection 2016. PubMed |
| Transduction-Transplantation Mouse Model of Myeloproliferative Neoplasm. Nguyen TK, Morse SJ, Fleischman AG. J Vis Exp. 2016 Dec 22;(118). doi: 10.3791/54624. PubMed |
| PPAR-alpha Activation Mediates Innate Host Defense through Induction of TFEB and Lipid Catabolism. Kim YS, Lee HM, Kim JK, Yang CS, Kim TS, Jung M, Jin HS, Kim S, Jang J, Oh GT, Kim JM, Jo EK. J Immunol. 2017 Apr 15;198(8):3283-3295. doi: 10.4049/jimmunol.1601920. Epub 2017 Mar 8. PubMed |
| Foxp3 Reprograms T Cell Metabolism to Function in Low-Glucose, High-Lactate Environments. Angelin A, Gil-de-Gomez L, Dahiya S, Jiao J, Guo L, Levine MH, Wang Z, Quinn WJ 3rd, Kopinski PK, Wang L, Akimova T, Liu Y, Bhatti TR, Han R, Laskin BL, Baur JA, Blair IA, Wallace DC, Hancock WW, Beier UH. Cell Metab. 2017 Jun 6;25(6):1282-1293.e7. doi: 10.1016/j.cmet.2016.12.018. Epub 2017 Apr 13. PubMed |
| JunB is essential for IL-23-dependent pathogenicity of Th17 cells. Hasan Z, Koizumi SI, Sasaki D, Yamada H, Arakaki N, Fujihara Y, Okitsu S, Shirahata H, Ishikawa H. Nat Commun. 2017 May 30;8:15628. doi: 10.1038/ncomms15628. PubMed |
| Ohmyungsamycins promote antimicrobial responses through autophagy activation via AMP-activated protein kinase pathway. Kim TS, Shin YH, Lee HM, Kim JK, Choe JH, Jang JC, Um S, Jin HS, Komatsu M, Cha GH, Chae HJ, Oh DC, Jo EK. Sci Rep. 2017 Jun 13;7(1):3431. doi: 10.1038/s41598-017-03477-3. PubMed |
| ESRRA (estrogen-related receptor alpha) is a key coordinator of transcriptional and post-translational activation of autophagy to promote innate host defense. Kim SY, Yang CS, Lee HM, Kim JK, Kim YS, Kim YR, Kim JS, Kim TS, Yuk JM, Dufour CR, Lee SH, Kim JM, Choi HS, Giguere V, Jo EK. Autophagy. 2018;14(1):152-168. doi: 10.1080/15548627.2017.1339001. Epub 2017 Sep 1. PubMed |
| Cell therapy could be a potential way to improve lipoprotein lipase deficiency. Wu W, Yin Y, Zhong J, Peng Y, Li S, Zheng L, Cao H, Zhang J. Lipids Health Dis. 2017 Oct 2;16(1):189. doi: 10.1186/s12944-017-0577-4. PubMed |
| Clodronate Improves Survival of Transplanted Hoxb8 Myeloid Progenitors with Constitutively Active GMCSFR in Immunocompetent Mice. Lee S, Kivimae S, Szoka FC. Mol Ther Methods Clin Dev. 2017 Sep 7;7:60-73. doi: 10.1016/j.omtm.2017.08.007. eCollection 2017 Dec 15. PubMed |
| Epigenetic targeting of bromodomain protein BRD4 counteracts cancer cachexia and prolongs survival. Segatto M, Fittipaldi R, Pin F, Sartori R, Dae Ko K, Zare H, Fenizia C, Zanchettin G, Pierobon ES, Hatakeyama S, Sperti C, Merigliano S, Sandri M, Filippakopoulos P, Costelli P, Sartorelli V, Caretti G. Nat Commun. 2017 Nov 22;8(1):1707. doi: 10.1038/s41467-017-01645-7. PubMed |
| The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages. Evavold CL, Ruan J, Tan Y, Xia S, Wu H, Kagan JC. Immunity. 2018 Jan 16;48(1):35-44.e6. doi: 10.1016/j.immuni.2017.11.013. Epub 2017 Nov 28. PubMed |
| The miR-17/92 cluster is involved in the molecular etiology of the SCLL syndrome driven by the BCR-FGFR1 chimeric kinase. Hu T, Chong Y, Qin H, Kitamura E, Chang CS, Silva J, Ren M, Cowell JK. Oncogene. 2018 Apr;37(14):1926-1938. doi: 10.1038/s41388-017-0091-1. Epub 2018 Jan 25. PubMed |
| Membrane bending occurs at all stages of clathrin-coat assembly and defines endocytic dynamics. Scott BL, Sochacki KA, Low-Nam ST, Bailey EM, Luu Q, Hor A, Dickey AM, Smith S, Kerkvliet JG, Taraska JW, Hoppe AD. Nat Commun. 2018 Jan 29;9(1):419. doi: 10.1038/s41467-018-02818-8. PubMed |
| Copper accumulation in senescent cells: Interplay between copper transporters and impaired autophagy. Masaldan S, Clatworthy SAS, Gamell C, Smith ZM, Francis PS, Denoyer D, Meggyesy PM, Fontaine S, Cater MA. Redox Biol. 2018 Jun;16:322-331. doi: 10.1016/j.redox.2018.03.007. Epub 2018 Mar 17. PubMed |
| MIR142 Loss-of-Function Mutations Derepress ASH1L to Increase HOXA Gene Expression and Promote Leukemogenesis. Trissal MC, Wong TN, Yao JC, Ramaswamy R, Kuo I, Baty J, Sun Y, Jih G, Parikh N, Berrien-Elliott MM, Fehniger TA, Ley TJ, Maillard I, Reddy PR, Link DC. Cancer Res. 2018 Jul 1;78(13):3510-3521. doi: 10.1158/0008-5472.CAN-17-3592. Epub 2018 May 3. PubMed |
| Phosphatidylinositol-5-Phosphate 4-Kinases Regulate Cellular Lipid Metabolism By Facilitating Autophagy. Lundquist MR, Goncalves MD, Loughran RM, Possik E, Vijayaraghavan T, Yang A, Pauli C, Ravi A, Verma A, Yang Z, Johnson JL, Wong JCY, Ma Y, Hwang KS, Weinkove D, Divecha N, Asara JM, Elemento O, Rubin MA, Kimmelman AC, Pause A, Cantley LC, Emerling BM. Mol Cell. 2018 May 3;70(3):531-544.e9. doi: 10.1016/j.molcel.2018.03.037. PubMed |
| Telomerase reverse transcriptase coordinates with the epithelial-to-mesenchymal transition through a feedback loop to define properties of breast cancer stem cells. El-Badawy A, Ghoneim NI, Nasr MA, Elkhenany H, Ahmed TA, Ahmed SM, El-Badri N. Biol Open. 2018 Jul 25;7(7). pii: bio.034181. doi: 10.1242/bio.034181. PubMed |
| Generation of Induced Cardiospheres via Reprogramming of Mouse Skin Fibroblasts. Lian W, Jia Y, Li L, Huang Z, Xu J. Curr Protoc Stem Cell Biol. 2018 Aug;46(1):e59. doi: 10.1002/cpsc.59. Epub 2018 Jul 12. PubMed |
| An Antiviral Branch of the IL-1 Signaling Pathway Restricts Immune-Evasive Virus Replication. Orzalli MH, Smith A, Jurado KA, Iwasaki A, Garlick JA, Kagan JC. Mol Cell. 2018 Sep 6;71(5):825-840.e6. doi: 10.1016/j.molcel.2018.07.009. Epub 2018 Aug 9. PubMed |
| Efficient CRISPR/Cas9-Mediated Mutagenesis in Primary Murine T Lymphocytes. Huang B, Johansen KH, Schwartzberg PL. Curr Protoc Immunol. 2019 Feb;124(1):e62. doi: 10.1002/cpim.62. Epub 2018 Oct 12. PubMed |
| Genome-wide analyses reveal the IRE1a-XBP1 pathway promotes T helper cell differentiation by resolving secretory stress and accelerating proliferation. Pramanik J, Chen X, Kar G, Henriksson J, Gomes T, Park JE, Natarajan K, Meyer KB, Miao Z, McKenzie ANJ, Mahata B, Teichmann SA. Genome Med. 2018 Oct 24;10(1):76. doi: 10.1186/s13073-018-0589-3. PubMed |
| The deubiquitinase MYSM1 dampens NOD2-mediated inflammation and tissue damage by inactivating the RIP2 complex. Panda S, Gekara NO. Nat Commun. 2018 Nov 7;9(1):4654. doi: 10.1038/s41467-018-07016-0. PubMed |
| Detecting Cellular Senescence in Reprogramming. Cazin C, von Joest M, Li H. Methods Mol Biol. 2019;1896:1-10. doi: 10.1007/978-1-4939-8931-7_1. PubMed |
| The HDAC-Associated Sin3B Protein Represses DREAM Complex Targets and Cooperates with APC/C to Promote Quiescence. Bainor AJ, Saini S, Calderon A, Casado-Polanco R, Giner-Ramirez B, Moncada C, Cantor DJ, Ernlund A, Litovchick L, David G. Cell Rep. 2018 Dec 4;25(10):2797-2807.e8. doi: 10.1016/j.celrep.2018.11.024. PubMed |
| Metabolic Imaging Reveals a Unique Preference of Symmetric Cell Division and Homing of Leukemia-Initiating Cells in an Endosteal Niche. Hao X, Gu H, Chen C, Huang D, Zhao Y, Xie L, Zou Y, Shu HS, Zhang Y, He X, Lai X, Zhang X, Zhou BO, Zhang CC, Chen GQ, Yu Z, Yang Y, Zheng J. Cell Metab. 2019 Apr 2;29(4):950-965.e6. doi: 10.1016/j.cmet.2018.11.013. Epub 2018 Dec 20. PubMed |
| REV-ERBalpha Regulates TH17 Cell Development and Autoimmunity. Amir M, Chaudhari S, Wang R, Campbell S, Mosure SA, Chopp LB, Lu Q, Shang J, Pelletier OB, He Y, Doebelin C, Cameron MD, Kojetin DJ, Kamenecka TM, Solt LA. Cell Rep. 2018 Dec 26;25(13):3733-3749.e8. doi: 10.1016/j.celrep.2018.11.101. PubMed |
Genome-wide CRISPR Screens in T Helper Cells Reveal Pervasive Crosstalk between Activation and Differentiation.
Henriksson J, Chen X, Gomes T, Ullah U, Meyer KB, Miragaia R, Duddy G, Pramanik J, Yusa K, Lahesmaa R, Teichmann SA.
Cell. 2019 Jan 7. pii: S0092-8674(18)31569-1. doi: 10.1016/j.cell.2018.11.044.
PubMed
Associated Plasmids |
| SIRT3 promotes antimycobacterial defenses by coordinating mitochondrial and autophagic functions. Kim TS, Jin YB, Kim YS, Kim S, Kim JK, Lee HM, Suh HW, Choe JH, Kim YJ, Koo BS, Kim HN, Jung M, Lee SH, Kim DK, Chung C, Son JW, Min JJ, Kim JM, Deng CX, Kim HS, Lee SR, Jo EK. Autophagy. 2019 Aug;15(8):1356-1375. doi: 10.1080/15548627.2019.1582743. Epub 2019 Mar 4. PubMed |
Phosphoinositide Interactions Position cGAS at the Plasma Membrane to Ensure Efficient Distinction between Self- and Viral DNA.
Barnett KC, Coronas-Serna JM, Zhou W, Ernandes MJ, Cao A, Kranzusch PJ, Kagan JC.
Cell. 2019 Mar 7;176(6):1432-1446.e11. doi: 10.1016/j.cell.2019.01.049. Epub 2019 Feb 28.
PubMed
Associated Plasmids |
Innate Immune Signaling Organelles Display Natural and Programmable Signaling Flexibility.
Tan Y, Kagan JC.
Cell. 2019 Apr 4;177(2):384-398.e11. doi: 10.1016/j.cell.2019.01.039. Epub 2019 Mar 7.
PubMed
Associated Plasmids |
| Generation of the human induced pluripotent stem cell (hiPSC) line PSMi007-A from a Long QT Syndrome type 1 patient carrier of two common variants in the NOS1AP gene. Mura M, Pisano F, Stefanello M, Ginevrino M, Boni M, Calabro F, Crotti L, Valente EM, Schwartz PJ, Brink PA, Gnecchi M. Stem Cell Res. 2019 Apr;36:101416. doi: 10.1016/j.scr.2019.101416. Epub 2019 Mar 6. PubMed |
| Lung cancer deficient in the tumor suppressor GATA4 is sensitive to TGFBR1 inhibition. Gao L, Hu Y, Tian Y, Fan Z, Wang K, Li H, Zhou Q, Zeng G, Hu X, Yu L, Zhou S, Tong X, Huang H, Chen H, Liu Q, Liu W, Zhang G, Zeng M, Zhou G, He Q, Ji H, Chen L. Nat Commun. 2019 Apr 10;10(1):1665. doi: 10.1038/s41467-019-09295-7. PubMed |
| Generation of the human induced pluripotent stem cell (hiPSC) line PSMi004-A from a carrier of the KCNQ1-R594Q mutation. Mura M, Lee YK, Pisano F, Ginevrino M, Boni M, Calabro F, Crotti L, Valente EM, Schwartz PJ, Tse HF, Gnecchi M. Stem Cell Res. 2019 May;37:101431. doi: 10.1016/j.scr.2019.101431. Epub 2019 Mar 27. PubMed |
| An effective mouse model for adoptive cancer immunotherapy targeting neoantigens. Hanada KI, Yu Z, Chappell GR, Park AS, Restifo NP. JCI Insight. 2019 May 16;4(10). pii: 124405. doi: 10.1172/jci.insight.124405. eCollection 2019 May 16. PubMed |
| bHLH Transcription Factor Math6 Antagonizes TGF-beta Signalling in Reprogramming, Pluripotency and Early Cell Fate Decisions. Divvela SSK, Nell P, Napirei M, Zaehres H, Chen J, Gerding WM, Nguyen HP, Gao S, Brand-Saberi B. Cells. 2019 Jun 2;8(6). pii: cells8060529. doi: 10.3390/cells8060529. PubMed |
| TCF1 and LEF1 Control Treg Competitive Survival and Tfr Development to Prevent Autoimmune Diseases. Yang BH, Wang K, Wan S, Liang Y, Yuan X, Dong Y, Cho S, Xu W, Jepsen K, Feng GS, Lu LF, Xue HH, Fu W. Cell Rep. 2019 Jun 18;27(12):3629-3645.e6. doi: 10.1016/j.celrep.2019.05.061. PubMed |
| Acetylation of BMAL1 by TIP60 controls BRD4-P-TEFb recruitment to circadian promoters. Petkau N, Budak H, Zhou X, Oster H, Eichele G. Elife. 2019 Jul 11;8. pii: 43235. doi: 10.7554/eLife.43235. PubMed |
| P11 Loss-of-Function is Associated with Decreased Cell Proliferation and Neurobehavioral Disorders in Mice. Liu G, Wang Y, Zheng W, Cheng H, Zhou R. Int J Biol Sci. 2019 May 20;15(7):1383-1395. doi: 10.7150/ijbs.33773. eCollection 2019. PubMed |
| Generation of Induced Pluripotent Cancer Cells from Glioblastoma Multiform Cell Lines. Vatanmakanian M, Yousefi H, Mashouri L, Aref AR, Khamisipour G, Bitaraf A, Alizadeh S. Cell Reprogram. 2019 Oct;21(5):238-248. doi: 10.1089/cell.2019.0046. Epub 2019 Aug 1. PubMed |
| A human immune dysregulation syndrome characterized by severe hyperinflammation with a homozygous nonsense Roquin-1 mutation. Tavernier SJ, Athanasopoulos V, Verloo P, Behrens G, Staal J, Bogaert DJ, Naesens L, De Bruyne M, Van Gassen S, Parthoens E, Ellyard J, Cappello J, Morris LX, Van Gorp H, Van Isterdael G, Saeys Y, Lamkanfi M, Schelstraete P, Dehoorne J, Bordon V, Van Coster R, Lambrecht BN, Menten B, Beyaert R, Vinuesa CG, Heissmeyer V, Dullaers M, Haerynck F. Nat Commun. 2019 Oct 21;10(1):4779. doi: 10.1038/s41467-019-12704-6. PubMed |
| Visualizing locus-specific sister chromatid exchange reveals differential patterns of replication stress-induced fragile site breakage. Waisertreiger I, Popovich K, Block M, Anderson KR, Barlow JH. Oncogene. 2020 Feb;39(6):1260-1272. doi: 10.1038/s41388-019-1054-5. Epub 2019 Oct 21. PubMed |
| 53BP1 Enforces Distinct Pre- and Post-resection Blocks on Homologous Recombination. Callen E, Zong D, Wu W, Wong N, Stanlie A, Ishikawa M, Pavani R, Dumitrache LC, Byrum AK, Mendez-Dorantes C, Martinez P, Canela A, Maman Y, Day A, Kruhlak MJ, Blasco MA, Stark JM, Mosammaparast N, McKinnon PJ, Nussenzweig A. Mol Cell. 2020 Jan 2;77(1):26-38.e7. doi: 10.1016/j.molcel.2019.09.024. Epub 2019 Oct 22. PubMed |
| CRISPR/Cas9 Gene Targeting in Primary Mouse Bone Marrow-Derived Macrophages. Bailis W. Methods Mol Biol. 2020;2097:223-230. doi: 10.1007/978-1-0716-0203-4_14. PubMed |
| Integrated transcriptomic and epigenetic data analysis identifiesaberrant expression of genes in acute myeloid leukemia with MLLAF9 translocation. Wang F, Li Z, Wang G, Tian X, Zhou J, Yu W, Fan Z, Dong L, Lu J, Xu J, Zhang W, Liang A. Mol Med Rep. 2020 Feb;21(2):883-893. doi: 10.3892/mmr.2019.10849. Epub 2019 Nov 26. PubMed |
| 53BP1/RIF1 signaling promotes cell survival after multifractionated radiotherapy. Eke I, Zong D, Aryankalayil MJ, Sandfort V, Bylicky MA, Rath BH, Graves EE, Nussenzweig A, Coleman CN. Nucleic Acids Res. 2020 Feb 20;48(3):1314-1326. doi: 10.1093/nar/gkz1139. PubMed |
| Targeting REGNASE-1 programs long-lived effector T cells for cancer therapy. Wei J, Long L, Zheng W, Dhungana Y, Lim SA, Guy C, Wang Y, Wang YD, Qian C, Xu B, Kc A, Saravia J, Huang H, Yu J, Doench JG, Geiger TL, Chi H. Nature. 2019 Dec;576(7787):471-476. doi: 10.1038/s41586-019-1821-z. Epub 2019 Dec 11. PubMed |
| miR-155 Overexpression in OT-1 CD8(+) T Cells Improves Anti-Tumor Activity against Low-Affinity Tumor Antigen. Monnot GC, Martinez-Usatorre A, Lanitis E, Lopes SF, Cheng WC, Ho PC, Irving M, Coukos G, Donda A, Romero P. Mol Ther Oncolytics. 2019 Dec 25;16:111-123. doi: 10.1016/j.omto.2019.12.008. eCollection 2020 Mar 27. PubMed |
| Targeting the PI5P4K Lipid Kinase Family in Cancer Using Covalent Inhibitors. Sivakumaren SC, Shim H, Zhang T, Ferguson FM, Lundquist MR, Browne CM, Seo HS, Paddock MN, Manz TD, Jiang B, Hao MF, Krishnan P, Wang DG, Yang TJ, Kwiatkowski NP, Ficarro SB, Cunningham JM, Marto JA, Dhe-Paganon S, Cantley LC, Gray NS. Cell Chem Biol. 2020 May 21;27(5):525-537.e6. doi: 10.1016/j.chembiol.2020.02.003. Epub 2020 Mar 3. PubMed |
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Multiplex T Cell Stimulation Assay Utilizing a T Cell Activation Reporter-Based Detection System.
Mann SE, Zhou Z, Landry LG, Anderson AM, Alkanani AK, Fischer J, Peakman M, Mallone R, Campbell K, Michels AW, Nakayama M.
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| Suppression of Inflammasome Activation by IRF8 and IRF4 in cDCs Is Critical for T Cell Priming. McDaniel MM, Kottyan LC, Singh H, Pasare C. Cell Rep. 2020 May 5;31(5):107604. doi: 10.1016/j.celrep.2020.107604. PubMed |
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| A Genome-wide CRISPR Screen Reveals a Role for the Non-canonical Nucleosome-Remodeling BAF Complex in Foxp3 Expression and Regulatory T Cell Function. Loo CS, Gatchalian J, Liang Y, Leblanc M, Xie M, Ho J, Venkatraghavan B, Hargreaves DC, Zheng Y. Immunity. 2020 Jul 14;53(1):143-157.e8. doi: 10.1016/j.immuni.2020.06.011. Epub 2020 Jul 7. PubMed |
| Impaired mitochondrial oxidative phosphorylation limits the self-renewal of T cells exposed to persistent antigen. Vardhana SA, Hwee MA, Berisa M, Wells DK, Yost KE, King B, Smith M, Herrera PS, Chang HY, Satpathy AT, van den Brink MRM, Cross JR, Thompson CB. Nat Immunol. 2020 Sep;21(9):1022-1033. doi: 10.1038/s41590-020-0725-2. Epub 2020 Jul 13. PubMed |
| Altered 3D chromatin structure permits inversional recombination at the IgH locus. Qiu X, Ma F, Zhao M, Cao Y, Shipp L, Liu A, Dutta A, Singh A, Braikia FZ, De S, Wood WH 3rd, Becker KG, Zhou W, Ji H, Zhao K, Atchison ML, Sen R. Sci Adv. 2020 Aug 14;6(33):eaaz8850. doi: 10.1126/sciadv.aaz8850. eCollection 2020 Aug. PubMed |
| Potential lung attack and lethality generated by EpCAM-specific CAR-T cells in immunocompetent mouse models. Qin D, Li D, Zhang B, Chen Y, Liao X, Li X, Alexander PB, Wang Y, Li QJ. Oncoimmunology. 2020 Aug 15;9(1):1806009. doi: 10.1080/2162402X.2020.1806009. PubMed |
| TGFbetaR-SMAD3 Signaling Induces Resistance to PARP Inhibitors in the Bone Marrow Microenvironment. Le BV, Podszywalow-Bartnicka P, Maifrede S, Sullivan-Reed K, Nieborowska-Skorska M, Golovine K, Yao JC, Nejati R, Cai KQ, Caruso LB, Swatler J, Dabrowski M, Lian Z, Valent P, Paietta EM, Levine RL, Fernandez HF, Tallman MS, Litzow MR, Huang J, Challen GA, Link D, Tempera I, Wasik MA, Piwocka K, Skorski T. Cell Rep. 2020 Oct 6;33(1):108221. doi: 10.1016/j.celrep.2020.108221. PubMed |
| ESRRA (estrogen related receptor alpha) is a critical regulator of intestinal homeostasis through activation of autophagic flux via gut microbiota. Kim S, Lee JY, Shin SG, Kim JK, Silwal P, Kim YJ, Shin NR, Kim PS, Won M, Lee SH, Kim SY, Sasai M, Yamamoto M, Kim JM, Bae JW, Jo EK. Autophagy. 2021 Oct;17(10):2856-2875. doi: 10.1080/15548627.2020.1847460. Epub 2020 Dec 15. PubMed |
| Malignant Transformation Involving CXXC4 Mutations Identified in a Leukemic Progression Model of Severe Congenital Neutropenia. Olofsen PA, Fatrai S, van Strien PMH, Obenauer JC, de Looper HWJ, Hoogenboezem RM, Erpelinck-Verschueren CAJ, Vermeulen MPWM, Roovers O, Haferlach T, Jansen JH, Ghazvini M, Bindels EMJ, Schneider RK, de Pater EM, Touw IP. Cell Rep Med. 2020 Aug 25;1(5):100074. doi: 10.1016/j.xcrm.2020.100074. eCollection 2020 Aug 25. PubMed |
MFSD12 mediates the import of cysteine into melanosomes and lysosomes.
Adelmann CH, Traunbauer AK, Chen B, Condon KJ, Chan SH, Kunchok T, Lewis CA, Sabatini DM.
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| The TGF-beta superfamily cytokine Activin-A is induced during autoimmune neuroinflammation and drives pathogenic Th17 cell differentiation. Wu B, Zhang S, Guo Z, Bi Y, Zhou M, Li P, Seyedsadr M, Xu X, Li JL, Markovic-Plese S, Wan YY. Immunity. 2021 Feb 9;54(2):308-323.e6. doi: 10.1016/j.immuni.2020.12.010. Epub 2021 Jan 8. PubMed |
| ATF3 downmodulates its new targets IFI6 and IFI27 to suppress the growth and migration of tongue squamous cell carcinoma cells. Xu L, Zu T, Li T, Li M, Mi J, Bai F, Liu G, Wen J, Li H, Brakebusch C, Wang X, Wu X. PLoS Genet. 2021 Feb 4;17(2):e1009283. doi: 10.1371/journal.pgen.1009283. eCollection 2021 Feb. PubMed |
| Modified Hypoxia-Inducible Factor Expression in CD8(+) T Cells Increases Antitumor Efficacy. Velica P, Cunha PP, Vojnovic N, Foskolou IP, Bargiela D, Gojkovic M, Rundqvist H, Johnson RS. Cancer Immunol Res. 2021 Apr;9(4):401-414. doi: 10.1158/2326-6066.CIR-20-0561. Epub 2021 Feb 18. PubMed |
| TRIM28 Expression on Dendritic Cells Prevents Excessive T Cell Priming by Silencing Endogenous Retrovirus. Chikuma S, Yamanaka S, Nakagawa S, Ueda MT, Hayabuchi H, Tokifuji Y, Kanayama M, Okamura T, Arase H, Yoshimura A. J Immunol. 2021 Apr 1;206(7):1528-1539. doi: 10.4049/jimmunol.2001003. Epub 2021 Feb 22. PubMed |
| Male sex chromosomal complement exacerbates the pathogenicity of Th17 cells in a chronic model of central nervous system autoimmunity. Doss PMIA, Umair M, Baillargeon J, Fazazi R, Fudge N, Akbar I, Yeola AP, Williams JB, Leclercq M, Joly-Beauparlant C, Beauchemin P, Ruda GF, Alpaugh M, Anderson AC, Brennan PE, Droit A, Lassmann H, Moore CS, Rangachari M. Cell Rep. 2021 Mar 9;34(10):108833. doi: 10.1016/j.celrep.2021.108833. PubMed |
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| PD-1 suppresses TCR-CD8 cooperativity during T-cell antigen recognition. Li K, Yuan Z, Lyu J, Ahn E, Davis SJ, Ahmed R, Zhu C. Nat Commun. 2021 May 12;12(1):2746. doi: 10.1038/s41467-021-22965-9. PubMed |
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| The Lysine Methylase SMYD3 Modulates Mesendodermal Commitment during Development. Fittipaldi R, Floris P, Proserpio V, Cotelli F, Beltrame M, Caretti G. Cells. 2021 May 18;10(5). pii: cells10051233. doi: 10.3390/cells10051233. PubMed |
| Mammalian cells use the autophagy process to restrict avian influenza virus replication. Liu S, Mok BW, Deng S, Liu H, Wang P, Song W, Chen P, Huang X, Zheng M, Lau SY, Cremin CJ, Tam CY, Li B, Jiang L, Chen Y, Yuen KY, Chen H. Cell Rep. 2021 Jun 8;35(10):109213. doi: 10.1016/j.celrep.2021.109213. PubMed |
| Expanding the Differentiation Potential of Already-Established Pluripotent Stem Cells. Gonzalez-Martinez J, Malumbres M. Methods Mol Biol. 2021 Jun 15. doi: 10.1007/7651_2021_408. PubMed |
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| Revealing molecular pathways for cancer cell fitness through a genetic screen of the cancer translatome. Kuzuoglu-Ozturk D, Hu Z, Rama M, Devericks E, Weiss J, Chiang GG, Worland ST, Brenner SE, Goodarzi H, Gilbert LA, Ruggero D. Cell Rep. 2021 Jun 29;35(13):109321. doi: 10.1016/j.celrep.2021.109321. PubMed |
| TET2 and DNMT3A Mutations Exert Divergent Effects on DNA Repair and Sensitivity of Leukemia Cells to PARP Inhibitors. Maifrede S, Le BV, Nieborowska-Skorska M, Golovine K, Sullivan-Reed K, Dunuwille WMB, Nacson J, Hulse M, Keith K, Madzo J, Caruso LB, Gazze Z, Lian Z, Padella A, Chitrala KN, Bartholdy BA, Matlawska-Wasowska K, Di Marcantonio D, Simonetti G, Greiner G, Sykes SM, Valent P, Paietta EM, Tallman MS, Fernandez HF, Litzow MR, Minden MD, Huang J, Martinelli G, Vassiliou GS, Tempera I, Piwocka K, Johnson N, Challen GA, Skorski T. Cancer Res. 2021 Oct 1;81(19):5089-5101. doi: 10.1158/0008-5472.CAN-20-3761. Epub 2021 Jul 2. PubMed |
| Nuclear NAD(+) homeostasis governed by NMNAT1 prevents apoptosis of acute myeloid leukemia stem cells. Shi X, Jiang Y, Kitano A, Hu T, Murdaugh RL, Li Y, Hoegenauer KA, Chen R, Takahashi K, Nakada D. Sci Adv. 2021 Jul 21;7(30). pii: 7/30/eabf3895. doi: 10.1126/sciadv.abf3895. Print 2021 Jul. PubMed |
| PD-1(+) Tcf1(+) CD8(+) T cells from established chronic infection can form memory while retaining a stableimprint of persistent antigen exposure. Charmoy M, Wyss T, Delorenzi M, Held W. Cell Rep. 2021 Sep 7;36(10):109672. doi: 10.1016/j.celrep.2021.109672. PubMed |
| Synthetic essentiality between PTEN and core dependency factor PAX7 dictates rhabdomyosarcoma identity. Langdon CG, Gadek KE, Garcia MR, Evans MK, Reed KB, Bush M, Hanna JA, Drummond CJ, Maguire MC, Leavey PJ, Finkelstein D, Jin H, Schreiner PA, Rehg JE, Hatley ME. Nat Commun. 2021 Sep 17;12(1):5520. doi: 10.1038/s41467-021-25829-4. PubMed |
| Perturbation-Based Modeling Unveils the Autophagic Modulation of Chemosensitivity and Immunogenicity in Breast Cancer Cells. Quiros-Fernandez I, Figueroa-Protti L, Arias-Arias JL, Brenes-Cordero N, Siles F, Mora J, Mora-Rodriguez RA. Metabolites. 2021 Sep 18;11(9). pii: metabo11090637. doi: 10.3390/metabo11090637. PubMed |
| Cancer-associated mutations in VAV1 trigger variegated signaling outputs and T-cell lymphomagenesis. Robles-Valero J, Fernandez-Nevado L, Lorenzo-Martin LF, Cuadrado M, Fernandez-Pisonero I, Rodriguez-Fdez S, Astorga-Simon EN, Abad A, Caloto R, Bustelo XR. EMBO J. 2021 Nov 15;40(22):e108125. doi: 10.15252/embj.2021108125. Epub 2021 Oct 7. PubMed |
| Nano-optogenetic engineering of CAR T cells for precision immunotherapy with enhanced safety. Nguyen NT, Huang K, Zeng H, Jing J, Wang R, Fang S, Chen J, Liu X, Huang Z, You MJ, Rao A, Huang Y, Han G, Zhou Y. Nat Nanotechnol. 2021 Dec;16(12):1424-1434. doi: 10.1038/s41565-021-00982-5. Epub 2021 Oct 25. PubMed |
| CRISPR screens unveil signal hubs for nutrient licensing of T cell immunity. Long L, Wei J, Lim SA, Raynor JL, Shi H, Connelly JP, Wang H, Guy C, Xie B, Chapman NM, Fu G, Wang Y, Huang H, Su W, Saravia J, Risch I, Wang YD, Li Y, Niu M, Dhungana Y, Kc A, Zhou P, Vogel P, Yu J, Pruett-Miller SM, Peng J, Chi H. Nature. 2021 Dec;600(7888):308-313. doi: 10.1038/s41586-021-04109-7. Epub 2021 Nov 18. PubMed |
| Disrupting Roquin-1 interaction with Regnase-1 induces autoimmunity and enhances antitumor responses. Behrens G, Edelmann SL, Raj T, Kronbeck N, Monecke T, Davydova E, Wong EH, Kifinger L, Giesert F, Kirmaier ME, Hohn C, de Jonge LS, Pisfil MG, Fu M, Theurich S, Feske S, Kawakami N, Wurst W, Niessing D, Heissmeyer V. Nat Immunol. 2021 Dec;22(12):1563-1576. doi: 10.1038/s41590-021-01064-3. Epub 2021 Nov 22. PubMed |
| Knockdown of Astrocytic Monocarboxylate Transporter 4 in the Motor Cortex Leads to Loss of Dendritic Spines and a Deficit in Motor Learning. Lundquist AJ, Llewellyn GN, Kishi SH, Jakowec NA, Cannon PM, Petzinger GM, Jakowec MW. Mol Neurobiol. 2022 Feb;59(2):1002-1017. doi: 10.1007/s12035-021-02651-z. Epub 2021 Nov 25. PubMed |
| Genome-wide fitness gene identification reveals Roquin as a potent suppressor of CD8 T cell expansion and anti-tumor immunity. Zhao H, Liu Y, Wang L, Jin G, Zhao X, Xu J, Zhang G, Ma Y, Yin N, Peng M. Cell Rep. 2021 Dec 7;37(10):110083. doi: 10.1016/j.celrep.2021.110083. PubMed |
| Regulation of positive and negative selection and TCR signaling during thymic T cell development by capicua. Kim S, Park GY, Park JS, Park J, Hong H, Lee Y. Elife. 2021 Dec 13;10:e71769. doi: 10.7554/eLife.71769. PubMed |
| An oncogenic enhancer encodes selective selenium dependency in AML. Eagle K, Jiang Y, Shi X, Li M, Obholzer NP, Hu T, Perez MW, Koren JV, Kitano A, Yi JS, Lin CY, Nakada D. Cell Stem Cell. 2022 Mar 3;29(3):386-399.e7. doi: 10.1016/j.stem.2022.01.003. Epub 2022 Feb 1. PubMed |
| The spliceosome component Usp39 controls B cell development by regulating immunoglobulin gene rearrangement. Ruan GX, Li Y, Chen W, Huang H, Zhang R, Chen C, Lam KP, Xu S, Ou X. Cell Rep. 2022 Feb 8;38(6):110338. doi: 10.1016/j.celrep.2022.110338. PubMed |
| High Metabolic Dependence on Oxidative Phosphorylation Drives Sensitivity to Metformin Treatment in MLL/AF9 Acute Myeloid Leukemia. Liu L, Patnana PK, Xie X, Frank D, Nimmagadda SC, Rosemann A, Liebmann M, Klotz L, Opalka B, Khandanpour C. Cancers (Basel). 2022 Jan 19;14(3). pii: cancers14030486. doi: 10.3390/cancers14030486. PubMed |
| Postnatal regulation of B-1a cell development and survival by the CIC-PER2-BHLHE41 axis. Hong H, Lee J, Park GY, Kim S, Park J, Park JS, Song Y, Lee S, Kim TJ, Lee YJ, Roh TY, Kwok SK, Kim SW, Tan Q, Lee Y. Cell Rep. 2022 Feb 15;38(7):110386. doi: 10.1016/j.celrep.2022.110386. PubMed |
| A clinically compatible drug-screening platform based on organotypic cultures identifies vulnerabilities to prevent and treat brain metastasis. Zhu L, Retana D, Garcia-Gomez P, Alvaro-Espinosa L, Priego N, Masmudi-Martin M, Yebra N, Miarka L, Hernandez-Encinas E, Blanco-Aparicio C, Martinez S, Sobrino C, Ajenjo N, Artiga MJ, Ortega-Paino E, Torres-Ruiz R, Rodriguez-Perales S, Soffietti R, Bertero L, Cassoni P, Weiss T, Munoz J, Sepulveda JM, Gonzalez-Leon P, Jimenez-Roldan L, Moreno LM, Esteban O, Perez-Nunez A, Hernandez-Lain A, Toldos O, Ruano Y, Alcazar L, Blasco G, Fernandez-Alen J, Caleiras E, Lafarga M, Megias D, Grana-Castro O, Nor C, Taylor MD, Young LS, Vareslija D, Cosgrove N, Couch FJ, Cusso L, Desco M, Mouron S, Quintela-Fandino M, Weller M, Pastor J, Valiente M. EMBO Mol Med. 2022 Mar 7;14(3):e14552. doi: 10.15252/emmm.202114552. Epub 2022 Feb 17. PubMed |
RIF1 acts in DNA repair through phosphopeptide recognition of 53BP1.
Setiaputra D, Escribano-Diaz C, Reinert JK, Sadana P, Zong D, Callen E, Sifri C, Seebacher J, Nussenzweig A, Thoma NH, Durocher D.
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| Gilteritinib enhances graft-versus-leukemia effects against FLT3-ITD mutant leukemia after allogeneic hematopoietic stem cell transplantation. Zhang Z, Hasegawa Y, Hashimoto D, Senjo H, Kikuchi R, Chen X, Yoneda K, Sekiguchi T, Kawase T, Tsuzuki H, Ishio T, Ara T, Ohigashi H, Nakagawa M, Teshima T. Bone Marrow Transplant. 2022 May;57(5):775-780. doi: 10.1038/s41409-022-01619-4. Epub 2022 Feb 28. PubMed |
| Novel Role of Prereplication Complex Component Cell Division Cycle 6 in Retinal Neovascularization. Kumar R, Rao GN. Arterioscler Thromb Vasc Biol. 2022 Apr;42(4):407-427. doi: 10.1161/ATVBAHA.121.317182. Epub 2022 Mar 3. PubMed |
| The KRAS-G12D mutation induces metabolic vulnerability in B-cell acute lymphoblastic leukemia. Xu Y, Fang H, Chen Y, Tang Y, Sun H, Kong Z, Yang F, Kirschner-Schwabe R, Zhu L, Toker A, Xiao N, Zhou BS, Li H. iScience. 2022 Feb 7;25(3):103881. doi: 10.1016/j.isci.2022.103881. eCollection 2022 Mar 18. PubMed |
| MLL::AF9 degradation induces rapid changes in transcriptional elongation and subsequent loss of an active chromatin landscape. Olsen SN, Godfrey L, Healy JP, Choi YA, Kai Y, Hatton C, Perner F, Haarer EL, Nabet B, Yuan GC, Armstrong SA. Mol Cell. 2022 Mar 17;82(6):1140-1155.e11. doi: 10.1016/j.molcel.2022.02.013. Epub 2022 Mar 3. PubMed |
| Vitamin B6 Metabolism Determines T Cell Anti-Tumor Responses. Bargiela D, Cunha PP, Velica P, Foskolou IP, Barbieri L, Rundqvist H, Johnson RS. Front Immunol. 2022 Feb 17;13:837669. doi: 10.3389/fimmu.2022.837669. eCollection 2022. PubMed |
| A saturation-mutagenesis analysis of the interplay between stability and activation in Ras. Hidalgo F, Nocka LM, Shah NH, Gorday K, Latorraca NR, Bandaru P, Templeton S, Lee D, Karandur D, Pelton JG, Marqusee S, Wemmer D, Kuriyan J. Elife. 2022 Mar 11;11. pii: 76595. doi: 10.7554/eLife.76595. PubMed |
| Chemical modulation of SQSTM1/p62-mediated xenophagy that targets a broad range of pathogenic bacteria. Lee YJ, Kim JK, Jung CH, Kim YJ, Jung EJ, Lee SH, Choi HR, Son YS, Shim SM, Jeon SM, Choe JH, Lee SH, Whang J, Sohn KC, Hur GM, Kim HT, Yeom J, Jo EK, Kwon YT. Autophagy. 2022 Apr 5:1-20. doi: 10.1080/15548627.2022.2054240. PubMed |
| Scinderin promotes fusion of electron transport chain dysfunctional muscle stem cells with myofibers. Wang X, Shelton SD, Bordieanu B, Frank AR, Yi Y, Venigalla SSK, Gu Z, Lenser NP, Glogauer M, Chandel NS, Zhao H, Zhao Z, McFadden DG, Mishra P. Nat Aging. 2022;2(2):155-169. doi: 10.1038/s43587-021-00164-x. Epub 2022 Jan 27. PubMed |
| Capybara: A computational tool to measure cell identity and fate transitions. Kong W, Fu YC, Holloway EM, Garipler G, Yang X, Mazzoni EO, Morris SA. Cell Stem Cell. 2022 Apr 7;29(4):635-649.e11. doi: 10.1016/j.stem.2022.03.001. Epub 2022 Mar 29. PubMed |
| MLL5 is involved in retinal photoreceptor maturation through facilitating CRX-mediated photoreceptor gene transactivation. Zhang X, Zhang BW, Xiang L, Wu H, Alexander SAS, Zhou P, Dai MZ, Wang X, Xiong W, Zhang Y, Jin ZB, Deng LW. iScience. 2022 Mar 11;25(4):104058. doi: 10.1016/j.isci.2022.104058. eCollection 2022 Apr 15. PubMed |
| CAR T cells expressing a bacterial virulence factor trigger potent bystander antitumour responses in solid cancers. Jin C, Ma J, Ramachandran M, Yu D, Essand M. Nat Biomed Eng. 2022 Jul;6(7):830-841. doi: 10.1038/s41551-022-00875-5. Epub 2022 Apr 4. PubMed |
| T Cell-Mediated Targeted Delivery of Anti-PD-L1 Nanobody Overcomes Poor Antibody Penetration and Improves PD-L1 Blocking at the Tumor Site. Petit PF, Bombart R, Desimpel PH, Naulaerts S, Thouvenel L, Collet JF, Van den Eynde BJ, Zhu J. Cancer Immunol Res. 2022 Jun 3;10(6):713-727. doi: 10.1158/2326-6066.CIR-21-0801. PubMed |
| Mapping the cardiac vascular niche in heart failure. Peisker F, Halder M, Nagai J, Ziegler S, Kaesler N, Hoeft K, Li R, Bindels EMJ, Kuppe C, Moellmann J, Lehrke M, Stoppe C, Schaub MT, Schneider RK, Costa I, Kramann R. Nat Commun. 2022 May 31;13(1):3027. doi: 10.1038/s41467-022-30682-0. PubMed |
| Superkine IL-2 and IL-33 Armored CAR T Cells Reshape the Tumor Microenvironment and Reduce Growth of Multiple Solid Tumors. Brog RA, Ferry SL, Schiebout CT, Messier CM, Cook WJ, Abdullah L, Zou J, Kumar P, Sentman CL, Frost HR, Huang YH. Cancer Immunol Res. 2022 Aug 3;10(8):962-977. doi: 10.1158/2326-6066.CIR-21-0536. PubMed |
| Functional requirements for a Samd14-capping protein complex in stress erythropoiesis. Ray S, Chee L, Zhou Y, Schaefer MA, Naldrett MJ, Alvarez S, Woods NT, Hewitt KJ. Elife. 2022 Jun 17;11:e76497. doi: 10.7554/eLife.76497. PubMed |
| Host B cells escape CAR-T immunotherapy by reversible downregulation of CD19. Fioretti S, Matson CA, Rosenberg KM, Singh NJ. Cancer Immunol Immunother. 2022 Jun 26. pii: 10.1007/s00262-022-03231-3. doi: 10.1007/s00262-022-03231-3. PubMed |
| Generation of hematopoietic lineage cell-specific chimeric mice using retrovirus-transduced fetal liver cells. Hong H, Lee Y. STAR Protoc. 2022 Sep 16;3(3):101526. doi: 10.1016/j.xpro.2022.101526. Epub 2022 Jul 1. PubMed |
| In vivo genome-wide CRISPR screening in murine acute myeloid leukemia uncovers microenvironmental dependencies. Mercier FE, Shi J, Sykes DB, Oki T, Jankovic M, Man CH, Kfoury YS, Miller E, He S, Zhu A, Vasic R, Doench J, Orthwein A, Michor F, Scadden DT. Blood Adv. 2022 Sep 13;6(17):5072-5084. doi: 10.1182/bloodadvances.2022007250. PubMed |
| Tumor cells dictate anti-tumor immune responses by altering pyruvate utilization and succinate signaling in CD8(+) T cells. Elia I, Rowe JH, Johnson S, Joshi S, Notarangelo G, Kurmi K, Weiss S, Freeman GJ, Sharpe AH, Haigis MC. Cell Metab. 2022 Aug 2;34(8):1137-1150.e6. doi: 10.1016/j.cmet.2022.06.008. Epub 2022 Jul 11. PubMed |
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Fully murine CD105-targeted CAR-T cells provide an immunocompetent model for CAR-T cell biology.
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| METTL16 drives leukemogenesis and leukemia stem cell self-renewal by reprogramming BCAA metabolism. Han L, Dong L, Leung K, Zhao Z, Li Y, Gao L, Chen Z, Xue J, Qing Y, Li W, Pokharel SP, Gao M, Chen M, Shen C, Tan B, Small A, Wang K, Zhang Z, Qin X, Yang L, Wunderlich M, Zhang B, Mulloy JC, Marcucci G, Chen CW, Wei M, Su R, Chen J, Deng X. Cell Stem Cell. 2023 Jan 5;30(1):52-68.e13. doi: 10.1016/j.stem.2022.12.006. PubMed |
| A conditional Smg6 mutant mouse model reveals circadian clock regulation through the nonsense-mediated mRNA decay pathway. Katsioudi G, Dreos R, Arpa ES, Gaspari S, Liechti A, Sato M, Gabriel CH, Kramer A, Brown SA, Gatfield D. Sci Adv. 2023 Jan 13;9(2):eade2828. doi: 10.1126/sciadv.ade2828. Epub 2023 Jan 13. PubMed |
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| Leishmania major drives host phagocyte death and cell-to-cell transfer depending on intracellular pathogen proliferation rate. Baars I, Jaedtka M, Dewitz LA, Fu Y, Franz T, Mohr J, Gintschel P, Berlin H, Degen A, Freier S, Rygol S, Schraven B, Kahlfuss S, van Zandbergen G, Muller AJ. JCI Insight. 2023 Jul 24;8(14):e169020. doi: 10.1172/jci.insight.169020. PubMed |
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Activation of GPR44 decreases severity of myeloid leukemia via specific targeting of leukemia initiating stem cells.
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| TET2-mediated mRNA demethylation regulates leukemia stem cell homing and self-renewal. Li Y, Xue M, Deng X, Dong L, Nguyen LXT, Ren L, Han L, Li C, Xue J, Zhao Z, Li W, Qing Y, Shen C, Tan B, Chen Z, Leung K, Wang K, Swaminathan S, Li L, Wunderlich M, Mulloy JC, Li X, Chen H, Zhang B, Horne D, Rosen ST, Marcucci G, Xu M, Li Z, Wei M, Tian J, Shen B, Su R, Chen J. Cell Stem Cell. 2023 Aug 3;30(8):1072-1090.e10. doi: 10.1016/j.stem.2023.07.001. PubMed |
| IL-15 armoring enhances the antitumor efficacy of claudin 18.2-targeting CAR-T cells in syngeneic mouse tumor models. Shi H, Li A, Dai Z, Xue J, Zhao Q, Tian J, Song D, Wang H, Chen J, Zhang X, Zhou K, Wei H, Qin S. Front Immunol. 2023 Jul 26;14:1165404. doi: 10.3389/fimmu.2023.1165404. eCollection 2023. PubMed |
| The miR-17 approximately 92 miRNAs promote plasma cell differentiation by suppressing SOCS3-mediated NIK degradation. Xie J, Du Y, Liu D, Wu J, Yang K, He X, Zhao J, Hong P, Liao K, Zhang H, Hong Y, Teijaro JR, Kang SG, Xiao C, Liu WH. Cell Rep. 2023 Aug 29;42(8):112968. doi: 10.1016/j.celrep.2023.112968. Epub 2023 Aug 13. PubMed |
| NKG2D-CAR T cells eliminate senescent cells in aged mice and nonhuman primates. Yang D, Sun B, Li S, Wei W, Liu X, Cui X, Zhang X, Liu N, Yan L, Deng Y, Zhao X. Sci Transl Med. 2023 Aug 16;15(709):eadd1951. doi: 10.1126/scitranslmed.add1951. Epub 2023 Aug 16. PubMed |
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| Progenitor-like exhausted SPRY1(+)CD8(+) T cells potentiate responsiveness to neoadjuvant PD-1 blockade in esophageal squamous cell carcinoma. Liu Z, Zhang Y, Ma N, Yang Y, Ma Y, Wang F, Wang Y, Wei J, Chen H, Tartarone A, Velotta JB, Dayyani F, Gabriel E, Wakefield CJ, Kidane B, Carbonelli C, Long L, Liu Z, Su J, Li Z. Cancer Cell. 2023 Nov 13;41(11):1852-1870.e9. doi: 10.1016/j.ccell.2023.09.011. Epub 2023 Oct 12. PubMed |
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| Cell volume controlled by LRRC8A-formed volume-regulated anion channels fine-tunes T cell activation and function. Wang Y, Sun Z, Ping J, Tang J, He B, Chang T, Zhou Q, Yuan S, Tang Z, Li X, Lu Y, He R, He X, Liu Z, Yin L, Wu N. Nat Commun. 2023 Nov 4;14(1):7075. doi: 10.1038/s41467-023-42817-y. PubMed |
| R-Loop Accumulation in Spliceosome Mutant Leukemias Confers Sensitivity to PARP1 Inhibition by Triggering Transcription-Replication Conflicts. Liu ZS, Sinha S, Bannister M, Song A, Arriaga-Gomez E, McKeeken AJ, Bonner EA, Hanson BK, Sarchi M, Takashima K, Zong D, Corral VM, Nguyen E, Yoo J, Chiraphapphaiboon W, Leibson C, McMahon MC, Rai S, Swisher EM, Sachs Z, Chatla S, Stirewalt DL, Deeg HJ, Skorski T, Papapetrou EP, Walter MJ, Graubert TA, Doulatov S, Lee SC, Nguyen HD. Cancer Res. 2024 Feb 15;84(4):577-597. doi: 10.1158/0008-5472.CAN-23-3239. PubMed |
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| Trans-vaccenic acid reprograms CD8(+) T cells and anti-tumour immunity. Fan H, Xia S, Xiang J, Li Y, Ross MO, Lim SA, Yang F, Tu J, Xie L, Dougherty U, Zhang FQ, Zheng Z, Zhang R, Wu R, Dong L, Su R, Chen X, Althaus T, Riedell PA, Jonker PB, Muir A, Lesinski GB, Rafiq S, Dhodapkar MV, Stock W, Odenike O, Patel AA, Opferman J, Tsuji T, Matsuzaki J, Shah H, Faubert B, Elf SE, Layden B, Bissonnette BM, He YY, Kline J, Mao H, Odunsi K, Gao X, Chi H, He C, Chen J. Nature. 2023 Nov;623(7989):1034-1043. doi: 10.1038/s41586-023-06749-3. Epub 2023 Nov 22. PubMed |
| Sphingolipid-Based Synergistic Interactions to Enhance Chemosensitivity in Lung Cancer Cells. Mesen-Porras S, Rojas-Cespedes A, Molina-Mora JA, Vega-Baudrit J, Siles F, Quiros S, Mora-Rodriguez R. Cells. 2023 Nov 8;12(22):2588. doi: 10.3390/cells12222588. PubMed |
| Leukemia-intrinsic determinants of CAR-T response revealed by iterative in vivo genome-wide CRISPR screening. Ramos A, Koch CE, Liu-Lupo Y, Hellinger RD, Kyung T, Abbott KL, Frose J, Goulet D, Gordon KS, Eidell KP, Leclerc P, Whittaker CA, Larson RC, Muscato AJ, Yates KB, Dubrot J, Doench JG, Regev A, Vander Heiden MG, Maus MV, Manguso RT, Birnbaum ME, Hemann MT. Nat Commun. 2023 Dec 5;14(1):8048. doi: 10.1038/s41467-023-43790-2. PubMed |
In vitro and in vivo modelling of mutant JAK3/STAT5 signaling in leukemia.
Omari SA, Kosasih HJ, Chung T, de Bock CE.
Heliyon. 2023 Nov 8;9(11):e22085. doi: 10.1016/j.heliyon.2023.e22085. eCollection 2023 Nov.
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| Intracellular K+ Limits T-cell Exhaustion and Preserves Antitumor Function. Collier C, Wucherer K, McWhorter M, Jenkins C, Bartlett A, Roychoudhuri R, Eil R. Cancer Immunol Res. 2024 Jan 3;12(1):36-47. doi: 10.1158/2326-6066.CIR-23-0319. PubMed |
| LILRB3 Supports Immunosuppressive Activity of Myeloid Cells and Tumor Development. Huang R, Liu X, Kim J, Deng H, Deng M, Gui X, Chen H, Wu G, Xiong W, Xie J, Lewis C, Homsi J, Yang X, Zhang C, He Y, Lou Q, Smith C, John S, Zhang N, An Z, Zhang CC. Cancer Immunol Res. 2024 Mar 4;12(3):350-362. doi: 10.1158/2326-6066.CIR-23-0496. PubMed |
Highly cooperative chimeric super-SOX induces naive pluripotency across species.
MacCarthy CM, Wu G, Malik V, Menuchin-Lasowski Y, Velychko T, Keshet G, Fan R, Bedzhov I, Church GM, Jauch R, Cojocaru V, Scholer HR, Velychko S.
Cell Stem Cell. 2024 Jan 4;31(1):127-147.e9. doi: 10.1016/j.stem.2023.11.010. Epub 2023 Dec 22.
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| Transgelin 2 guards T cell lipid metabolic programming and anti-tumor function. Hwang SM, Awasthi D, Jeong J, Sandoval TA, Chae CS, Ramos Y, Tan C, Falco MM, McBain IT, Mishra B, Ivashkiv LB, Zamarin D, Cantillo E, Chapman-Davis E, Holcomb K, Morales DK, Rodriguez PC, Conejo-Garcia JR, Kaczocha M, Vaharautio A, Song M, Cubillos-Ruiz JR. Res Sq [Preprint]. 2023 Dec 14:rs.3.rs-3683989. doi: 10.21203/rs.3.rs-3683989/v1. PubMed |
| CD8+ T cell metabolic flexibility elicited by CD28-ARS2 axis-driven alternative splicing of PKM supports antitumor immunity. Holling GA, Chavel CA, Sharda AP, Lieberman MM, James CM, Lightman SM, Tong JH, Qiao G, Emmons TR, Giridharan T, Hou S, Intlekofer AM, Higashi RM, Fan TWM, Lane AN, Eng KH, Segal BH, Repasky EA, Lee KP, Olejniczak SH. Cell Mol Immunol. 2024 Mar;21(3):260-274. doi: 10.1038/s41423-024-01124-2. Epub 2024 Jan 18. PubMed |
| The CUL5 E3 ligase complex negatively regulates central signaling pathways in CD8(+) T cells. Liao X, Li W, Zhou H, Rajendran BK, Li A, Ren J, Luan Y, Calderwood DA, Turk B, Tang W, Liu Y, Wu D. Nat Commun. 2024 Jan 19;15(1):603. doi: 10.1038/s41467-024-44885-0. PubMed |
| A pathologically expanded, clonal lineage of IL-21 producing CD4+ T cells drives Inflammatory neuropathy. Seyedsadr M, Bang M, McCarthy E, Zhang S, Chen HC, Mohebbi M, Hugo W, Whitmire JK, Lechner MG, Su MA. bioRxiv [Preprint]. 2024 Jan 8:2024.01.07.574553. doi: 10.1101/2024.01.07.574553. PubMed |
T cell help shapes B cell tolerance.
Akama-Garren EH, Yin X, Prestwood TR, Ma M, Utz PJ, Carroll MC.
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| Suppression of the METTL3-m(6)A-integrin beta1 axis by extracellular acidification impairs T cell infiltration and antitumor activity. Wang Z, Shang J, Qiu Y, Cheng H, Tao M, Xie E, Pei X, Li W, Zhang L, Wu A, Li G. Cell Rep. 2024 Feb 27;43(2):113796. doi: 10.1016/j.celrep.2024.113796. Epub 2024 Feb 16. PubMed |
| NR4a1/2 deletion promotes accumulation of TCF1(+) stem-like precursors of exhausted CD8(+) T cells in the tumor microenvironment. Srirat T, Hayakawa T, Mise-Omata S, Nakagawara K, Ando M, Shichino S, Ito M, Yoshimura A. Cell Rep. 2024 Mar 26;43(3):113898. doi: 10.1016/j.celrep.2024.113898. Epub 2024 Mar 6. PubMed |
| Structural basis for self-discrimination by neoantigen-specific TCRs. Finnigan JP, Newman JH, Patskovsky Y, Patskovska L, Ishizuka AS, Lynn GM, Seder RA, Krogsgaard M, Bhardwaj N. Nat Commun. 2024 Mar 8;15(1):2140. doi: 10.1038/s41467-024-46367-9. PubMed |
| The thymocyte-specific RNA-binding protein Arpp21 provides TCR repertoire diversity by binding to the 3'-UTR and promoting Rag1 mRNA expression. Xu M, Ito-Kureha T, Kang HS, Chernev A, Raj T, Hoefig KP, Hohn C, Giesert F, Wang Y, Pan W, Zietara N, Straub T, Feederle R, Daniel C, Adler B, Konig J, Feske S, Tsokos GC, Wurst W, Urlaub H, Sattler M, Kisielow J, Wulczyn FG, Lyszkiewicz M, Heissmeyer V. Nat Commun. 2024 Mar 11;15(1):2194. doi: 10.1038/s41467-024-46371-z. PubMed |
| Multimodal stimulation screens reveal unique and shared genes limiting T cell fitness. Lin CP, Levy PL, Alflen A, Apriamashvili G, Ligtenberg MA, Vredevoogd DW, Bleijerveld OB, Alkan F, Malka Y, Hoekman L, Markovits E, George A, Traets JJH, Krijgsman O, van Vliet A, Pozniak J, Pulido-Vicuna CA, de Bruijn B, van Hal-van Veen SE, Boshuizen J, van der Helm PW, Diaz-Gomez J, Warda H, Behrens LM, Mardesic P, Dehni B, Visser NL, Marine JC, Markel G, Faller WJ, Altelaar M, Agami R, Besser MJ, Peeper DS. Cancer Cell. 2024 Apr 8;42(4):623-645.e10. doi: 10.1016/j.ccell.2024.02.016. Epub 2024 Mar 14. PubMed |
| Antigen-independent, autonomous B cell receptor signaling drives activated B cell DLBCL. Eken JA, Koning MT, Kupcova K, Sepulveda Yanez JH, de Groen RAL, Quinten E, Janssen J, van Bergen CAM, Vermaat JSP, Cleven A, Navarrete MA, Ylstra B, de Jong D, Havranek O, Jumaa H, Veelken H. J Exp Med. 2024 May 6;221(5):e20230941. doi: 10.1084/jem.20230941. Epub 2024 Mar 21. PubMed |
| Induction of immortal-like and functional CAR T cells by defined factors. Wang L, Jin G, Zhou Q, Liu Y, Zhao X, Li Z, Yin N, Peng M. J Exp Med. 2024 May 6;221(5):e20232368. doi: 10.1084/jem.20232368. Epub 2024 Mar 26. PubMed |
| Recurrent mutations in tumor suppressor FBXW7 bypass Wnt/beta-catenin addiction in cancer. Zhong Z, Virshup DM. Sci Adv. 2024 Apr 5;10(14):eadk1031. doi: 10.1126/sciadv.adk1031. Epub 2024 Apr 3. PubMed |
| The DNA damage-independent ATM signalling maintains CBP/DOT1L axis in MLL rearranged acute myeloid leukaemia. Wang G, Zhang W, Ren J, Zeng Y, Dang X, Tian X, Yu W, Li Z, Ma Y, Yang P, Lu J, Zheng J, Lu B, Xu J, Liang A. Oncogene. 2024 Jun;43(25):1900-1916. doi: 10.1038/s41388-024-02998-2. Epub 2024 Apr 26. PubMed |
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| CD4 T cell depletion increases memory differentiation of endogenous and CAR T cells and enhances the efficacy of Super2 and IL-33-armored CAR T cells against solid tumors. Mohamed AO, Boone DT, Ferry SL, Peck MC, Santos AM, Soderholm HE, Wittling MC, Paulos C, Turk MJ, Huang YH. J Immunother Cancer. 2025 Feb 11;13(2):e009994. doi: 10.1136/jitc-2024-009994. PubMed |
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| CD37 regulates the self-renewal of leukemic stem cells via integrin-mediated signaling in acute myeloid leukemia. Lu J, Lv L, Tian X, Li Z, Ma Y, Li N, Wang J, Wang G, Zeng Y, Zhang W, Xu J, Liang A. Stem Cell Reports. 2025 May 13;20(5):102476. doi: 10.1016/j.stemcr.2025.102476. Epub 2025 Apr 17. PubMed |
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| CXCL13 Expression Promotes CAR T Cell Antitumor Activity and Potentiates Response to PD-1 Blockade. Zhou Y, Zhao W, Zhu Y, Liu H, Sun Y, Gong Z, Li X, Liu Z, Wen K, Wang Y, Ren J, Xiao R, Jiang L, Hu Y, Bi E, Zhang X. Adv Sci (Weinh). 2025 Sep;12(33):e08095. doi: 10.1002/advs.202508095. Epub 2025 Jun 10. PubMed |
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