375 results

1. ClonTracer Barcoding Library (7.5 ug)

   Pooled Library

   #69830

   Purpose

   High complexity 30bp-long semi random DNA barcode library in lentiviral backbone

   Depositor

   Frank Stegmeier

   Article

   Bhang et al Nat Med. 2015 Apr 13. doi: 10.1038/nm.38

   Expression

   Mammalian

   Species

   Synthetic

   Use

   Lentiviral

   Available since

   Sept. 11, 2015

   Availability

   Academic Institutions and Nonprofits only

2. Sabatini/Lander Lab Activity-Optimized Genome-wide Mouse sgRNA Library in pLenti-sgRNA

   Pooled Library

   #1000000096

   Purpose

   CRISPR gRNA knockout pooled library for targeting the mouse genome

   Depositor

   David Sabatini, Eric Lander

   Available since

   April 3, 2017

   Availability

   Academic Institutions and Nonprofits only

3. mCRISPRa-v2, genome-wide, 10 sgRNAs/gene

   Pooled Library

   #1000000093

   Purpose

   Genome-wide CRISPR gRNA pooled library for activation of mouse genes

   Depositor

   Jonathan Weissman

   Available since

   Nov. 15, 2016

   Availability

   Academic Institutions and Nonprofits only

4. hCRISPRa-v2, Mitochondria, Trafficking, and Motility (h4), top 5 sgRNAs/gene

   Pooled Library

   #83983

   Purpose

   Human CRISPRa Pooled Library targeting Mitochondria, Trafficking, and Motility genes

   Depositor

   Jonathan Weissman

   Article

   Horlbeck et al Elife. 2016 Sep 23;5. pii: e19760. doi:

   Available since

   Jan. 12, 2017

   Availability

   Academic Institutions and Nonprofits only

5. Human Brunello kinome pooled library, guides 1-4 in lentiGuide-Puro backbone

   Pooled Library

   #75312

   Purpose

   Human sgRNA library in backbone lentiGuide-Puro targeting 763 kinase genes and containing 3,052 unique sgRNAs along with 100 non-targeting controls

   Depositor

   John Doench, David Root

   Article

   Doench et al Nat Biotechnol. 2016 Jan 18. doi: 10.103

   Expression

   Mammalian

   Use

   CRISPR and Lentiviral

   Available since

   June 27, 2016

   Availability

   Academic Institutions and Nonprofits only

6. Synuclein VHH Immune Library

   Pooled Library

   #1000000071

   Purpose

   Synuclein phagemid VHH phage display library

   Depositor

   Anne Messer, Michael J Fox Foundation MJFF

   Available since

   June 14, 2016

   Availability

   Industry, Academic Institutions, and Nonprofits

7. mCRISPRa-v2, Gene Expression (m5), top 5 sgRNAs/gene

   Pooled Library

   #84002

   Purpose

   Mouse CRISPRa Pooled Library targeting gene expression

   Depositor

   Jonathan Weissman

   Article

   Horlbeck et al Elife. 2016 Sep 23;5. pii: e19760. doi:

   Available since

   Jan. 12, 2017

   Availability

   Academic Institutions and Nonprofits only

8. Human CRISPR Knockout Pooled Library (H3)

   Pooled Library

   #133914

   Purpose

   CRISPR gRNA knockout pooled library for targeting the human genome - version H3

   Depositor

   Xiaole Shirley Liu, Myles Brown

   Expression

   Mammalian

   Species

   Homo sapiens

   Use

   CRISPR and Lentiviral

   Available since

   Jan. 24, 2020

   Availability

   Academic Institutions and Nonprofits only

9. Wei lab paired-guide RNA (pgRNA) CRISPR–Cas9 library for human long non-coding RNAs (lncRNAs)

   Pooled Library

   #89640

   Purpose

   Paired sgRNA library containing 12,472 pgRNAs targeting 671 human long non-coding RNAs (lncRNAs)

   Depositor

   Wensheng Wei

   Article

   Zhu et al Nat Biotechnol. 2016 Dec;34(12):1279-128

   Expression

   Mammalian

   Use

   Lentiviral

   Available since

   May 17, 2017

   Availability

   Academic Institutions and Nonprofits only

10. hCRISPRa-v2, Stress and Proteostasis (h3), top 5 sgRNAs/gene

    Pooled Library

    #83982

    Purpose

    Human CRISPRa Pooled Library targeting stress and proteostasis genes

    Depositor

    Jonathan Weissman

    Article

    Horlbeck et al Elife. 2016 Sep 23;5. pii: e19760. doi:

    Available since

    Jan. 12, 2017

    Availability

    Academic Institutions and Nonprofits only

11. Mouse Base Editing Sensor Library

    Pooled Library

    #179217

    Purpose

    sgRNAs that target frequently occurring cancer associated mutations identified in the MSK IMPACT dataset that can be modeled with cytosine base editing.

    Depositor

    Lukas Dow

    Article

    Sanchez-Rivera et al Nat Biotechnol. 2022 Feb 14. pii: 10.103

    Expression

    Mammalian

    Use

    Lentiviral

    Available since

    June 16, 2022

    Availability

    Academic Institutions and Nonprofits only

12. pRep-Cap Scanning Saturation Mutagenesis (SSM) pooled library

    Pooled Library

    #199601

    Purpose

    pRep-Cap SSM library enables VP1, VP2, and VP3 expression under the control of the endogenous p40 promoter

    Depositor

    George Church

    Article

    Ogden et al Science. 2019 Nov 29;366(6469):1139-1143

    Expression

    Mammalian

    Species

    Aav2

    Use

    AAV

    Available since

    June 13, 2023

    Availability

    Academic Institutions and Nonprofits only

13. Sabatini/Lander Lab Activity-Optimized Genome-wide Human sgRNA Library in pLenti-sgRNA

    Pooled Library

    #1000000095

    Purpose

    CRISPR gRNA knockout pooled library for targeting the human genome

    Depositor

    David Sabatini, Eric Lander

    Available since

    April 3, 2017

    Availability

    Academic Institutions and Nonprofits only

14. hCRISPRa-v2, Unassigned (h7), top 5 sgRNAs/gene

    Pooled Library

    #83986

    Purpose

    Human CRISPRa Pooled Library targeting unassigned genes

    Depositor

    Jonathan Weissman

    Article

    Horlbeck et al Elife. 2016 Sep 23;5. pii: e19760. doi:

    Available since

    Jan. 12, 2017

    Availability

    Academic Institutions and Nonprofits only

15. Human lentiviral CRISPR library_v1

    Pooled Library

    #69763

    Purpose

    Genome-scale sgRNA screening library in lentiviral vector pLB, targeting 20,121 human protein-coding genes

    Depositor

    Haoquan Wu

    Article

    Ma et al Cell Rep. 2015 Jul 28;12(4):673-83. doi:

    Expression

    Mammalian

    Species

    Homo sapiens

    Use

    CRISPR and Lentiviral

    Available since

    Feb. 9, 2016

    Availability

    Academic Institutions and Nonprofits only

16. CRISPRi non-coding library (CRiNCL) - Common to all 7 cell lines

    Pooled Library

    #86538

    Depositor

    Jonathan Weissman

    Article

    Liu et al Science. 2017 Jan 06. Vol. 355, Issue 63

    Available since

    March 8, 2017

    Availability

    Academic Institutions and Nonprofits only

17. mCRISPRa-v2, Mitochondria, Trafficking, and Motility (m4), top 5 sgRNAs/gene

    Pooled Library

    #84001

    Purpose

    Mouse CRISPRa Pooled Library targeting Mitochondria, Trafficking, and Motility genes

    Depositor

    Jonathan Weissman

    Article

    Horlbeck et al Elife. 2016 Sep 23;5. pii: e19760. doi:

    Available since

    Jan. 12, 2017

    Availability

    Academic Institutions and Nonprofits only

18. mCRISPRa-v2, Stress and Proteostasis (m3), top 5 sgRNAs/gene

    Pooled Library

    #84000

    Purpose

    Mouse CRISPRi Pooled Library targeting stress and proteostasis genes

    Depositor

    Jonathan Weissman

    Article

    Horlbeck et al Elife. 2016 Sep 23;5. pii: e19760. doi:

    Available since

    Jan. 12, 2017

    Availability

    Academic Institutions and Nonprofits only

19. hCRISPRi-v2, Cancer and Apoptosis (h2), top 5 sgRNAs/gene

    Pooled Library

    #83972

    Purpose

    Human CRISPRi Pooled Library targeting cancer and apoptosis genes

    Depositor

    Jonathan Weissman

    Article

    Horlbeck et al Elife. 2016 Sep 23;5. pii: e19760. doi:

    Available since

    Dec. 14, 2016

    Availability

    Academic Institutions and Nonprofits only

20. Human Lentiviral sgRNA Library - Control

    Pooled Library

    #51048

    Purpose

    Sub-pool of Sabatini/Lander sgRNA library enriched for control targets.

    Depositor

    David Sabatini, Eric Lander

    Article

    Wang et al Science. 2014 Jan 3;343(6166):80-4. doi:

    Expression

    Mammalian

    Species

    Homo sapiens

    Use

    CRISPR and Lentiviral

    Available since

    Feb. 7, 2014

    Availability

    Academic Institutions and Nonprofits only

21. Barcode Library 1 (BCL1)

    Pooled Library

    #179852

    Purpose

    Lentiviral barcode library that consists of 10^6 unique barcodes. Barcodes consist of 12bp degenerate region followed by two stable bases (C or G) and 4bp unique library code CCAA.

    Depositor

    Jason Moffat

    Article

    Rehman et al Cell. 2021 Jan 7;184(1):226-242.e21. doi

    Expression

    Mammalian

    Use

    Lentiviral

    Available since

    May 12, 2022

    Availability

    Academic Institutions and Nonprofits only

22. mCRISPRa-v2, Unassigned (m7), top 5 sgRNAs/gene

    Pooled Library

    #84004

    Purpose

    Mouse CRISPRa Pooled Library targeting unassigned genes

    Depositor

    Jonathan Weissman

    Article

    Horlbeck et al Elife. 2016 Sep 23;5. pii: e19760. doi:

    Available since

    Jan. 12, 2017

    Availability

    Academic Institutions and Nonprofits only

23. CRISPRi non-coding library (CRiNCL) - Unique to HEK293T

    Pooled Library

    #86543

    Depositor

    Jonathan Weissman

    Article

    Liu et al Science. 2017 Jan 06. Vol. 355, Issue 63

    Available since

    March 8, 2017

    Availability

    Academic Institutions and Nonprofits only

24. hCRISPRi-v2, Stress and Proteostasis (h3), top 5 sgRNAs/gene

    Pooled Library

    #83973

    Purpose

    Human CRISPRi Pooled Library targeting stress and proteostasis genes

    Depositor

    Jonathan Weissman

    Article

    Horlbeck et al Elife. 2016 Sep 23;5. pii: e19760. doi:

    Available since

    Dec. 14, 2016

    Availability

    Academic Institutions and Nonprofits only

25. SARS-CoV-2 RBD Wuhan-Hu-1 SSM Library

    Pooled Library

    #1000000182

    Depositor

    Jesse Bloom

    Available since

    June 14, 2022

    Availability

    Academic Institutions and Nonprofits only

26. mTF-CRISPRai

    Pooled Library

    #122131

    Purpose

    Expresses gRNAs for mouse transcription factor-CRISPR activation

    Depositor

    Stanley Qi

    Article

    Liu et al Cell Stem Cell. 2018 Sep 28. pii: S1934-

    Expression

    Mammalian

    Species

    Mus musculus

    Use

    CRISPR and Lentiviral

    Available since

    April 25, 2019

    Availability

    Academic Institutions and Nonprofits only

27. sgRNA pool for Streptococcus pneumoniae

    Pooled Library

    #170432

    Purpose

    CRISPR library targeting S. pneumoniae D39V

    Depositor

    Jan-Willem Veening

    Article

    Liu et al Cell Host Microbe. 2021 Jan 13;29(1):107

    Expression

    Bacterial

    Use

    CRISPR

    Available since

    Aug. 31, 2021

    Availability

    Academic Institutions and Nonprofits only

28. pCMV-Rep78/68 Scanning Saturation Mutagenesis (SSM)

    Pooled Library

    #198050

    Purpose

    By supplying an AAV cap gene of interest in trans, researchers can use this library to investigate the effects of rep mutations on production of a wide range of AAV capsid serotypes

    Depositor

    George Church

    Article

    Jain et al bioRxiv 2023.01.31.526541

    Expression

    Mammalian

    Use

    AAV

    Available since

    May 4, 2023

    Availability

    Academic Institutions and Nonprofits only

29. PYR1 Double Mutant Library

    Pooled Library

    #1000000181

    Depositor

    Timothy Whitehead

    Available since

    June 21, 2022

    Availability

    Academic Institutions and Nonprofits only

30. Pan-Druggable Cancer Library

    Pooled Library

    #182133

    Purpose

    All-in-one CRISPR/Cas system with 74 individual elements. 63 elements target cancer-related genes with FDA-approved drug treatments, and 3 elements target key medulloblastoma driver genes.

    Depositor

    Prashant Mali

    Article

    Hu et al Biomaterials. 2022 Jan;280:121276. doi:

    Species

    Homo sapiens

    Use

    CRISPR and Lentiviral

    Available since

    Aug. 26, 2022

    Availability

    Academic Institutions and Nonprofits only

31. pCVSN2c-MCP-oScarlet-KASH-6xMS2 Barcode Library

    Pooled Library

    #227672

    Purpose

    RVdG genome plasmids that carry an error-correctable barcode compatible with 3’ capture single cell or single nuclei RNA sequencing readout. For the production of CVS N2c strain G-deleted rabies virus

    Depositor

    Cathryn Cadwell, Tomasz Nowakowski

    Article

    Shin et al bioRxiv [Preprint]. 2024 Dec 11:2024.10.

    Expression

    Mammalian

    Species

    Synthetic

    Available since

    Feb. 12, 2025

    Availability

    Academic Institutions and Nonprofits only

32. pUC57kan-T7-mt-gRNA library

    Pooled Library

    #82480

    Purpose

    Pool of sgRNAs to remove mouse mitochondrial DNA reads in the sequencing of genomic libraries

    Depositor

    Wei Xie

    Article

    Wu et al Nature. 2016 Jun 30;534(7609):652-7.

    Available since

    April 5, 2017

    Availability

    Academic Institutions and Nonprofits only

33. Human Lentiviral sgRNA Library - Ribosomal Proteins

    Pooled Library

    #51045

    Purpose

    Sub-pool of Sabatini/Lander sgRNA library enriched for ribosomal gene targets.

    Depositor

    David Sabatini, Eric Lander

    Article

    Wang et al Science. 2014 Jan 3;343(6166):80-4. doi:

    Expression

    Mammalian

    Species

    Homo sapiens

    Use

    CRISPR and Lentiviral

    Available since

    Feb. 7, 2014

    Availability

    Academic Institutions and Nonprofits only

34. p11-5’_10xN_PAM-site4 (RTW574)

    Pooled Library

    #160135

    Purpose

    Plasmid library harboring a randomized 10nt PAM 5’ of target site 4. Can be used to profile CRISPR-Cas PAM requirements of enzymes that recognize 5’ PAMs (e.g. Cas12a)

    Depositor

    Benjamin Kleinstiver, Keith Joung

    Article

    Walton et al Nat Protoc. 2021 Feb 5. pii: 10.1038/s41

    Species

    Synthetic

    Use

    CRISPR

    Available since

    Feb. 8, 2021

    Availability

    Academic Institutions and Nonprofits only

35. Human Lentiviral sgRNA Library - Unknown Function

    Pooled Library

    #51043

    Purpose

    Sub-pool of Sabatini/Lander sgRNA library enriched for gene targets of unknown function.

    Depositor

    David Sabatini, Eric Lander

    Article

    Wang et al Science. 2014 Jan 3;343(6166):80-4. doi:

    Expression

    Mammalian

    Species

    Homo sapiens

    Use

    CRISPR and Lentiviral

    Available since

    Feb. 7, 2014

    Availability

    Academic Institutions and Nonprofits only

36. SARS-CoV-2_RBD_DMS_Library

    Pooled Library

    #1000000172

    Depositor

    Jesse Bloom

    Available since

    March 29, 2021

    Availability

    Academic Institutions and Nonprofits only

37. CRISPRi non-coding library (CRiNCL) - iPSC & HFF

    Pooled Library

    #86550

    Depositor

    Jonathan Weissman

    Article

    Liu et al Science. 2017 Jan 06. Vol. 355, Issue 63

    Available since

    March 8, 2017

    Availability

    Academic Institutions and Nonprofits only

38. Lourido Toxoplasma CRISPR Library V1

    Pooled Library

    #80636

    Purpose

    Plasmid sgRNA library containing ten guides against each of the 8,158 predicted Toxoplasma gondii protein coding genes.

    Depositor

    Sebastian Lourido

    Article

    Sidik et al Cell. 2016 Sep 8;166(6):1423-1435.e12. d

    Available since

    Sept. 19, 2016

    Availability

    Academic Institutions and Nonprofits only

39. Human Brunello kinome pooled library, guides 5-8 in lentiCRISPRv2 backbone

    Pooled Library

    #75315

    Purpose

    Human sgRNA library in backbone lentiCRISPRv2 targeting 763 kinase genes and containing 3,052 unique sgRNAs along with 100 non-targeting controls

    Depositor

    John Doench, David Root

    Article

    Doench et al Nat Biotechnol. 2016 Jan 18. doi: 10.103

    Expression

    Mammalian

    Use

    CRISPR and Lentiviral

    Available since

    June 27, 2016

    Availability

    Academic Institutions and Nonprofits only

40. CRISPRi non-coding library (CRiNCL) - Unique to HFF

    Pooled Library

    #86541

    Depositor

    Jonathan Weissman

    Article

    Liu et al Science. 2017 Jan 06. Vol. 355, Issue 63

    Available since

    March 8, 2017

    Availability

    Academic Institutions and Nonprofits only

41. scQers promoter control series (p027, p028, p029, p041, p042)

    Pooled Library

    #1000000239

    Depositor

    Jay Shendure

    Available since

    April 3, 2024

    Availability

    Academic Institutions and Nonprofits only

42. SARS-CoV-2 RBD Omicron BA.1 SSM Library

    Pooled Library

    #1000000187

    Depositor

    Jesse Bloom

    Available since

    June 14, 2022

    Availability

    Academic Institutions and Nonprofits only

43. Human Transporter Knockout Library with UMIs

    Pooled Library

    #221409

    Purpose

    gRNA library to test the impact of transporters on biological processes

    Depositor

    RESOLUTE Consortium, Giulio Superti-Furga

    Article

    Wolf et al Cell Chem Biol. 2024 Dec 24:S2451-9456(2

    Species

    Homo sapiens

    Use

    CRISPR and Lentiviral

    Available since

    Sept. 13, 2024

    Availability

    Academic Institutions and Nonprofits only

44. CRISPRi non-coding library (CRiNCL) - Unique to K562

    Pooled Library

    #86544

    Depositor

    Jonathan Weissman

    Article

    Liu et al Science. 2017 Jan 06. Vol. 355, Issue 63

    Available since

    March 8, 2017

    Availability

    Academic Institutions and Nonprofits only

45. CRISPRi non-coding library (CRiNCL) - Common to all 5 cancer cell lines

    Pooled Library

    #86539

    Depositor

    Jonathan Weissman

    Article

    Liu et al Science. 2017 Jan 06. Vol. 355, Issue 63

    Available since

    March 8, 2017

    Availability

    Academic Institutions and Nonprofits only

46. Human Whole Genome sgRNA iBAR Library

    Pooled Library

    #140633

    Purpose

    CRISPR pooled screen at high MOI by the embedded internal barcodes

    Depositor

    Wensheng Wei

    Article

    Zhu et al Genome Biol. 2019 Jan 24;20(1):20. doi:

    Use

    CRISPR and Lentiviral

    Available since

    April 21, 2020

    Availability

    Academic Institutions and Nonprofits only

47. hCRISPRi_dual_3_4

    Pooled Library

    #187247

    Purpose

    Ultra-compact, human genome-wide CRISPRi library targeting each gene with a single element encoding a dual sgRNA cassette.

    Depositor

    Jonathan Weissman, Marco Jost

    Article

    Replogle et al eLife. 2022 Dec 28;11:e81856. doi: 10.75

    Species

    Synthetic

    Use

    Lentiviral

    Available since

    Sept. 30, 2022

    Availability

    Academic Institutions and Nonprofits only

48. SARS-CoV-2 RBD XBB.1.5 SSM Library

    Pooled Library

    #1000000232

    Depositor

    Tyler Starr

    Available since

    Oct. 25, 2023

    Availability

    Academic Institutions and Nonprofits only

49. Toronto KnockOut Library (TKOv1)

    Pooled Library

    #1000000069

    Purpose

    CRISPR gRNA knockout pooled library for targeting the human genome

    Depositor

    Jason Moffat, Stephane Angers

    Available since

    Jan. 28, 2016

    Availability

    Academic Institutions and Nonprofits only

50. lentiGuide-Puro-pKO-library

    Pooled Library

    #190744

    Purpose

    CRISPR/Cas9 paired-guide RNA library to delete proximal poly(A) sites in mouse melanoma.

    Depositor

    Robert Bradley

    Article

    Gabel et al Nat Commun. 2024 Feb 1;15(1):959. doi: 1

    Expression

    Mammalian

    Species

    Mus musculus

    Use

    CRISPR, Lentiviral, and Mouse Targeting

    Available since

    Feb. 2, 2024

    Availability

    Academic Institutions and Nonprofits only