Viral Vector Packaging Service: Optogenetics AAV
Optogenetic tools can be used to control cell activity in living tissue with light. Optogenetics is typically used in neuroscience to control electrical potentials in neurons. See our Optogenetics Plasmids and Optogenetics Guide page for more information about this field.
Use the table and filters below to find ready-to-use AAV preparations of optogenetics plasmids available in Addgene's collection.
| ID | Name | Promoter | Opsin Variant | Tag | Activity | Serotype | PI |
|---|---|---|---|---|---|---|---|
| 20071 | pACAGW-ChR2-Venus-AAV | CAG | ChR2 | Venus | Constitutive | 1, 9 | Karel Svoboda |
| 83898 | pAAV-mDlx-ChR2-mCherry-Fishell-3 | Dlx | ChR2 | mCherry | Constitutive | 1, 9, rg* | Gordon Fishell |
| 135634 | pAAV-S5E2-ChR2-mCherry | nEF | ChR2 | mCherry | Constitutive | 1, 9, PHPeB | Jordane Dimidschstein |
| 137142 | pAAV-nEF-Con/Fon-ChR2-mCherry | nEF | ChR2 | mCherry | Cre and Flp dependent | 8 | Karl Deisseroth |
| 137143 | pAAV-nEF-Con/Foff 2.0-ChR2-mCherry | nEF | ChR2 | mCherry | Cre dependent | 8 | Karl Deisseroth |
| 137144 | pAAV-nEF-Coff/Fon-ChR2-mCherry | nEF | ChR2 | mCherry | Flp dependent | 8 | Karl Deisseroth |
| 137163 | pAAV-nEF-Con/Foff 2.0-ChR2-EYFP | nEF | ChR2 | EYFP | Cre dependent | 8 | Karl Deisseroth |
| 20297 | pAAV-EF1a-double floxed-hChR2(H134R)-mCherry-WPRE-HGHpA | EF1a | ChR2/H134R | mCherry | Cre dependent | 1, 5, 8, 9, rg* | Karl Deisseroth |
| 20298 | pAAV-EF1a-double floxed-hChR2(H134R)-EYFP-WPRE-HGHpA | EF1a | ChR2/H134R | EYFP | Cre dependent | 1, 5, 9, rg*, PHPeB | Karl Deisseroth |
| 26969 | pAAV-CaMKIIa-hChR2(H134R)-EYFP | CaMKII | ChR2/H134R | EYFP | Constitutive | 1, 2, 5, 9 | Karl Deisseroth |
| 26973 | pAAV-hSyn-hChR2(H134R)-EYFP | Syn | ChR2/H134R | EYFP | Constitutive | 1, 2, 5, 9, rg*, PHPeB | Karl Deisseroth |
| 26975 | pAAV-CaMKIIa-hChR2(H134R)-mCherry | CaMKII | ChR2/H134R | mCherry | Constitutive | 1, 5, 9, rg* | Karl Deisseroth |
| 26976 | pAAV-hSyn-hChR2(H134R)-mCherry | Syn | ChR2/H134R | mCherry | Constitutive | 5, 8, 9 | Karl Deisseroth |
| 28017 | AAV-CAG-hChR2-H134R-tdTomato | CAG | ChR2/H134R | tdTomato | Constitutive | rg* | Karel Svoboda |
| 75470 | pAAV-CAG-FLEXFRT-ChR2(H134R)-mCherry | CAG | ChR2/H134R | mCherry | Flp dependent | 1 | Connie Cepko |
| 55639 | pAAV-Ef1a-fDIO hChR2(H134R)-EYFP | EF1a | ChR2/H134R | EYFP | Flp dependent | rg* | Karl Deisseroth |
| 55645 | pAAV-hSyn Con/Fon hChR2(H134R)-EYFP | Syn | ChR2/H134R | EYFP | Cre and Flp dependent | 5, 8, 9, rg* | Karl Deisseroth |
| 58880 | pAAV-Syn-ChR2(H134R)-GFP | Syn | ChR2/H134R | GFP | Constitutive | 8, rg* | Edward Boyden |
| 100054 | pAAV.CAG.hChR2(H134R)-mCherry.WPRE.SV40 | CAG | ChR2/H134R | mCherry | Constitutive | 1, 2, 5, 9 | Karl Deisseroth |
| 127090 | pAAV-CAG-DIO-ChR2(H134R)-eYFP | CAG | ChR2/H134R | EYFP | Cre dependent | PHPeB | Viviana Gradinaru |
| 107708 | pAAV-hSynapsin- soCoChR-GFP | Syn | CoChR (soma-targeted) | GFP | Constitutive | 9 | Edward Boyden |
| 107712 | pAAV-hSynapsin-FLEX-soCoChR-GFP | Syn | CoChR (soma-targeted) | GFP | Cre dependent | 9 | Edward Boyden |
| 35505 | pAAV-CaMKIIa-hChR2(E123A)-EYFP | CaMKII | ChR2(E123A) | EYFP | Constitutive | 9 | Karl Deisseroth |
| 35506 | pAAV-CaMKIIa-hChR2(E123A)-mCherry | CaMKII | ChR2(E123A) | mCherry | Constitutive | 9 | Karl Deisseroth |
| 35509 | pAAV-Ef1a-DIO hChR2(E123T/T159C)-EYFP | EF1a | ChR2(E123T/T159C) | EYFP | Cre dependent | 5, 9 | Karl Deisseroth |
| 137139 | pAAV-nEF-Con/Fon-ChR2(ET/TC)-EYFP | nEF | ChR2(E123T/T159C) | EYFP | Cre and Flp dependent | 8 | Karl Deisseroth |
| 137140 | pAAV-nEF-Con/Foff 2.0-ChR2(ET/TC)-EYFP | nEF | ChR2(E123T/T159C) | EYFP | Cre dependent | 8 | Karl Deisseroth |
| 137141 | pAAV-nEF-Coff/Fon-ChR2(ET/TC)-EYFP | nEF | ChR2(E123T/T159C) | EYFP | Flp dependent | 8 | Karl Deisseroth |
| 26968 | pAAV-Ef1a-DIO ChETA-EYFP | EF1a | ChETA | EYFP | Cre dependent | 1, 5, 9 | Karl Deisseroth |
| 35497 | pAAV-Ef1a-DIO C1V1 (t/t)-TS-EYFP | EF1a | C1V1 (t/t) | EYFP | Cre dependent | 9 | Karl Deisseroth |
| 35499 | pAAV-CaMKIIa-C1V1 (t/t)-TS-EYFP | CaMKII | C1V1 (t/t) | EYFP | Constitutive | 9 | Karl Deisseroth |
| 122063 | pAAV-EF1α1.1-ChrimsonR-GFP | EF1a | ChrimsonR | GFP | Constitutive | 2 | Edward Boyden |
| 124650 | pAAV-CamKIIa-C1V1(t/t)-mScarlet-KV2.1 | CaMKII | C1V1 (t/t) | mScarlet | Constitutive | 9 | Christopher Harvey |
| 59170 | pAAV-Syn-Chronos-GFP | Syn | Chronos | GFP | Constitutive | 1, 5, rg* | Edward Boyden |
| 59171 | pAAV-Syn-ChrimsonR-tdT | Syn | ChrimsonR | tdTomato | Constitutive | 1, 5, 9 | Edward Boyden |
| 62723 | pAAV-Syn-FLEX-rc[ChrimsonR-tdTomato] | Syn | ChrimsonR | tdTomato | Cre dependent | 1, 5 | Edward Boyden |
| 62726 | pAAV-Syn-Chronos-tdTomato | Syn | Chronos | tdTomato | Constitutive | 8 | Edward Boyden |
| 130909 | AAV-CAG-FLPX-rc [ChrimsonR-tdTomato] | CAG | ChrimsonR | tdTomato | Flp dependent | 8 | Edward Boyden |
| 100049 | pAAV.hSynap.ChETA(E123T/H134R)-eYFP.WPRE.hGH | Syn | ChETA | EYFP | Constitutive | 1, 9 | Karl Deisseroth |
| 100050 | pAAV.CaMKIIa.ChETA(E123T/H134R)-eYFP.WPRE.hGH | CaMKII | ChETA | EYFP | Constitutive | 9 | Karl Deisseroth |
| 135633 | pAAV-S5E2-C1V1-eYFP | E2 | C1V1 | EYFP | Constitutive | 1, 5, 9, PHPeB | Jordane Dimidschstein |
| 100061 | pAAV-Ef1a-DIO C1V1 (t/t)-TS-mCherry | EF1a | C1V1 (t/t) | mCherry | Cre dependent | 9 | Karl Deisseroth |
| 105448 | pAAV-hSyn-DIO-ChrimsonR-mRuby2-ST | Syn | ChrimsonR (soma-targeted) | mRuby2 | Cre dependent | 9 | Hillel Adesnik |
| 124603 | pAAV-EF1a-DIO-ChrimsonR-mRuby2-KV2.1-WPRE-SV40 | EF1a | ChrimsonR (soma-targeted) | mRuby2 | Cre dependent | 9 | Christopher Harvey |
| 108912 | pAAV-CAG-DIO-ChroME-ST-P2A-H2B-mRuby3 | CAG | ChroME (soma-targeted) | mRuby3 | Cre dependent | 9 | Hillel Adesnik |
| 124651 | pAAV-CamKIIa-ChrimsonR-mScarlet-KV2.1 | CaMKII | ChrimsonR (soma-targeted) | mScarlet | Constitutive | 1, 9 | Christopher Harvey |
| 130991 | pAAV-CaMKIIa-ChRmine-mScarlet-Kv2.1-WPRE | CamKII | ChRmine (high-photocurrent, red-shifted) | mScarlet | Constitutive | 8 | Karl Deisseroth |
| 130995 | pAAV-hSyn-ChRmine-mScarlet-Kv2.1-WPRE | Syn | ChRmine (high-photocurrent, red-shifted) | mScarlet | Constitutive | 8 | Karl Deisseroth |
| 130998 | pAAV-Ef1a-DIO-ChRmine-mScarlet-WPRE | EF1a | ChRmine (high-photocurrent, red-shifted) | mScarlet | Cre dependent | 1, 5 | Karl Deisseroth |
| 131004 | pAAV-hSyn-GCaMP 6m-p2A-ChRmine-Kv2.1-WPRE | Syn | ChRmine (high-photocurrent, red-shifted) | GCaMP6m | Constitutive | 8 | Karl Deisseroth |
| 137158 | pAAV-nEF-ChRmine-mScarlet | nEF | ChRmine (high-photocurrent, red-shifted) | mScarlet | Constitutive | 8 | Karl Deisseroth |
| 137159 | pAAV-nEF-Con/Fon-ChRmine-oScarlet | nEF | ChRmine (high-photocurrent, red-shifted) | oScarlet | Cre and Flp dependent | 8 | Karl Deisseroth |
| 137160 | pAAV-nEF-Coff/Fon-ChRmine-oScarlet | nEF | ChRmine (high-photocurrent, red-shifted) | oScarlet | Flp dependent | 8 | Karl Deisseroth |
| 137161 | pAAV-nEF-Con/Foff 2.0-ChRmine-oScarlet | nEF | ChRmine (high-photocurrent, red-shifted) | oScarlet | Cre dependent | 8 | Karl Deisseroth |
| 171027 | pAAV-Ef1a-fDIO-ChrimsonR-tdTomato | EF1a | ChrimsonR | tdTomato | Flp dependent | 1, 9 | Patricia Jensen |
| 174007 | pAAV-hSyn-DIO-jGCaMP8s-P2A-ChrimsonR-ST | Syn | ChrimsonR (soma-targeted) | GCaMP8s | Cre dependent | 9 | Mark Histed |
| 183519 | pAAV-CaMKIIa-ChRmine-oScarlet-KV 2.1-WPRE | CamKII | ChRmine (high-photocurrent, red-shifted) | oScarlet | Constitutive | 8 | Karl Deisseroth |
| 22222 | AAV-FLEX-Arch-GFP | CAG | Arch | GFP | Cre dependent | 1, 9 | Edward Boyden |
| 28305 | pAAV-FLEX-ArchT-tdTomato | CAG | ArchT | tdTomato | Cre dependent | 5 | Edward Boyden |
| 50972 | AAV-SYP1-miniSOG-T2A-mCherry | Syn | InSynC (non-opsin) | mCherry | Constitutive | 8 | Roger Tsien |
| 99039 | pAAV-CamKII-ArchT-GFP (PV2527) | CaMKII | ArchT | GFP | Constitutive | 1, 5, 9, rg* | Edward Boyden |
| 137148 | pAAV-nEF-Con/Fon-Arch3.3-p2a-EYFP | nEF | Arch3.3 | EYFP | Cre and Flp dependent | 8 | Karl Deisseroth |
| 137149 | pAAV-nEF-Con/Foff 2.0-Arch3.3-EYFP | nEF | Arch3.3 | EYFP | Cre dependent | 8 | Karl Deisseroth |
| 137150 | pAAV-nEF-Coff/Fon-Arch3.3-p2a-EYFP | nEF | Arch3.3 | EYFP | Flp dependent | 8 | Karl Deisseroth |
| 20949 | pAAV-double floxed-eNpHR-EYFP-WPRE-pA | EF1a | eNpHR | EYFP | Cre dependent | 9 | Karl Deisseroth |
| 26966 | AAV-Ef1a-DIO eNpHR 3.0-EYFP | EF1a | eNpHR 3.0 | EYFP | Cre dependent | 1, 5, 9, rg* | Karl Deisseroth |
| 26971 | pAAV-CaMKIIa-eNpHR 3.0-EYFP | CaMKII | eNpHR 3.0 | EYFP | Constitutive | 1, 9 | Karl Deisseroth |
| 26972 | pAAV-hSyn-eNpHR 3.0-EYFP | Syn | eNpHR 3.0 | EYFP | Constitutive | 2, 5 | Karl Deisseroth |
| 137151 | pAAV-nEF-NpHR3.3-EYFP | nEF | NpHR 3.3 | EYFP | Constitutive | 8 | Karl Deisseroth |
| 137152 | pAAV-nEF-Con/Fon-NpHR3.3-EYFP | nEF | NpHR 3.3 | EYFP | Cre and Flp dependent | 8 | Karl Deisseroth |
| 137153 | pAAV-nEF-Con/Foff 2.0-NpHR3.3-EYFP | nEF | NpHR 3.3 | EYFP | Cre dependent | 8 | Karl Deisseroth |
| 137154 | pAAV-nEF-Coff/Fon-NpHR3.3-EYFP | nEF | NpHR 3.3 | EYFP | Flp dependent | 8 | Karl Deisseroth |
| 65014 | pAAV-hsyn-Jaws-KGC-GFP-ER2 | Syn | Jaws | GFP | Constitutive | 5, 8, rg* | Edward Boyden |
| 84445 | pAAV-CAG-FLEX-rc [Jaws-KGC-GFP-ER2] | CAG | Jaws | GFP | Cre dependent | 1, 5, rg* | Edward Boyden |
| 84446 | pAAV-CAG-FLEX-rc [Jaws-KGC-tdTomato-ER2] | CAG | Jaws | tdTomato | Cre dependent | 1, 5, 8 | Edward Boyden |
| 105669 | pAAV-CKIIa-stGtACR2-FusionRed | CaMKII | GtACR2 (soma-targeted) | FusionRed | Constitutive | 1, rg* | Ofer Yizhar |
| 105677 | pAAV_hSyn1-SIO-stGtACR2-FusionRed | Syn | GtACR2 (soma-targeted) | FusionRed | Cre dependent | 1, 5, rg* | Ofer Yizhar |
| 105678 | pAAV_hSyn1-SIO-stGtACR1-FusionRed | Syn | GtACR1 (soma-targeted) | FusionRed | Cre dependent | 5 | Ofer Yizhar |
| 109048 | pAAV-CAG-DIO-NLS-mRuby3-IRES-eGtACR1-ST | CAG | eGtACR1 (soma-targeted) | mRuby3 | Cre dependent | 9 | Hillel Adesnik |
| 137155 | pAAV-nEF-Con/Fon-iC++-EYFP | nEF | iC++ | EYFP | Cre and Flp dependent | 8 | Karl Deisseroth |
| 137156 | pAAV-nEF-Con/Foff 2.0-iC++-EYFP | nEF | iC++ | EYFP | Cre dependent | 8 | Karl Deisseroth |
| 137157 | pAAV-nEF-Coff/Fon-iC++-EYFP | nEF | iC++ | EYFP | Flp dependent | 8 | Karl Deisseroth |
| 125712 | pAAV-CaMKIIa(0.4)-eOPN3-mScarlet-WPRE | CaMKII | eOPN3 | mScarlet | Constitutive | 1, 5, rg* | Ofer Yizhar |
| 125713 | AAV-hSyn1-SIO-eOPN3-mScarlet-WPRE | Syn | eOPN3 | mScarlet | Cre dependent | 1, 5 | Ofer Yizhar |
| 139504 | pAAV-CAG-DIO-PPO-Venus | CAG | PPO | Venus | Cre dependent | 5 | Michael Bruchas |
| 139505 | pAAV-Ef1a-DIO-PPO-Venus | EF1a | PPO | Venus | Cre dependent | 8, 9 | Michael Bruchas |
| 198510 | pAAV_hSyn-PdCO-mScarlet-WPRE | Syn | PdCO | mScarlet | Constitutive | 1, 5 | Ofer Yizhar |
| 198511 | pAAV_hSyn-DIO-PdCO-mScarlet-WPRE | Syn | PdCO | mScarlet | Cre dependent | 1, 5 | Ofer Yizhar |
| 198513 | pAAV_hSyn-PdCO-EGFP-WPRE | Syn | PdCO | EGFP | Constitutive | 1, 5 | Ofer Yizhar |
| 198516 | pAAV_EF1a-DIO-PdCO-mScarlet-ER-miniWPRE | EF1a | PdCO | mScarlet | Cre dependent | 1, 5 | Ofer Yizhar |
| 202199 | pAAV_hSyn-SIO-stChrimsonR-EGFP-P2A-PdCO-miniWPRE | Syn | PdCO, ChrimsonR (soma-targeted) | EGFP | Cre dependent | 1, 5 | Ofer Yizhar |
| 205997 | pAAV_hSyn_WiChR_TS_mScarlet_ER | Syn | WiChr | mScarlet | Constitutive | 9 | Peter Hegemann, Johannes Vierock |
| 154948 | CaMKII-somBiPOLES-mCerulean | CamKII | BiPOLES (soma-targeted) | mCerulean | Constitutive | 5, 9, rg* | Simon Wiegert |
| 154951 | hSyn-DIO-somBiPOLES-mCerulean | Syn | BiPOLES (soma-targeted) | mCerulean | Cre dependent | 5, 9, rg* | Simon Wiegert |
No available items found to match all requested criteria. Please consider using fewer filtering options.
Browse all Optogenetics AAV
*AAVrg = retrograde serotype, produced with the AAV retro helper plasmid from the Karpova and Schaffer labs. See the Retrograde AAV Inventory Page.
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