375 results

1. Mouse metabolism knockout library

   Pooled Library

   #160129

   Purpose

   CRISPR library targets mouse metabolic genes

   Depositor

   Kivanc Birsoy

   Article

   Zhu et al Cell Metab. 2020 Oct 28. pii: S1550-4131

   Expression

   Mammalian

   Species

   Mus musculus

   Use

   CRISPR and Lentiviral

   Available since

   Nov. 10, 2020

   Availability

   Academic Institutions and Nonprofits only

2. hCRISPRa-v2, genome-wide, 10 sgRNAs/gene

   Pooled Library

   #1000000091

   Purpose

   Genome-wide CRISPR gRNA pooled library for activation of human genes

   Depositor

   Jonathan Weissman

   Available since

   Nov. 15, 2016

   Availability

   Academic Institutions and Nonprofits only

3. FNLCR CRISPRa Cell Surface

   Pooled Library

   #207471

   Purpose

   CRISPR-based activation library with guide RNAs targeting all cell surface proteins.

   Depositor

   Raj Chari

   Article

   Yang et al Sci Adv. 2024 Feb 16;10(7):eadj2445. doi

   Expression

   Mammalian

   Species

   Homo sapiens

   Use

   CRISPR and Lentiviral

   Available since

   Jan. 24, 2024

   Availability

   Academic Institutions and Nonprofits only

4. lentiCRISPRv2_ISG

   Pooled Library

   #125753

   Purpose

   Expresses gRNAs targeting human Interferon-Stimulated Genes

   Depositor

   Molly OhAinle, Michael Emerman

   Article

   Roesch et al Retrovirology. 2018 Mar 20;15(1):26. doi

   Expression

   Mammalian

   Species

   Homo sapiens

   Use

   CRISPR and Lentiviral

   Available since

   May 7, 2020

   Availability

   Academic Institutions and Nonprofits only

5. Dual sgRNA CRISPRa Library

   Pooled Library

   #1000000193

   Depositor

   Jonathan Weissman

   Available since

   Sept. 30, 2022

   Availability

   Academic Institutions and Nonprofits only

6. ClonTracer Barcoding Library (2.5 ug)

   Pooled Library

   #67267

   Purpose

   High complexity 30bp-long semi random DNA barcode library in lentiviral backbone

   Depositor

   Frank Stegmeier

   Article

   Bhang et al Nat Med. 2015 Apr 13. doi: 10.1038/nm.38

   Expression

   Mammalian

   Species

   Synthetic

   Use

   Lentiviral

   Available since

   Sept. 11, 2015

   Availability

   Academic Institutions and Nonprofits only

7. DDR_MKOv4

   Pooled Library

   #140219

   Purpose

   CRISPR DNA damage response library

   Depositor

   Junjie Chen

   Article

   Su et al DNA Repair (Amst). 2020 Jan 16;87:102803

   Expression

   Mammalian

   Species

   Homo sapiens

   Use

   CRISPR and Lentiviral

   Available since

   Aug. 20, 2021

   Availability

   Academic Institutions and Nonprofits only

8. Human CRISPRa sgRNA library Calabrese in backbone XPR_502 (P65 HSF), Set A

   Pooled Library

   #92379

   Purpose

   CRISPRa

   Depositor

   David Root, John Doench

   Article

   Sanson et al Nat Commun. 2018 Dec 21;9(1):5416. doi:

   Has Service

   Lentiviral Prep

   Use

   Lentiviral

   Available since

   Aug. 3, 2017

   Availability

   Academic Institutions and Nonprofits only

9. Mouse CRISPRa sgRNA library Caprano in backbone XPR_502 (P65 HSF), Set A

   Pooled Library

   #92383

   Purpose

   CRISPRa

   Depositor

   David Root, John Doench

   Article

   Sanson et al Nat Commun. 2018 Dec 21;9(1):5416. doi:

   Expression

   Mammalian

   Use

   CRISPR and Lentiviral

   Available since

   July 13, 2018

   Availability

   Academic Institutions and Nonprofits only

10. FNLCR CRISPRa Cell Surface and FNLCR CRISPRa Soluble Libraries

    Pooled Library

    #1000000228

    Depositor

    Raj Chari

    Available since

    Jan. 24, 2024

    Availability

    Academic Institutions and Nonprofits only

11. Human SAM library in lentiSAMv2 backbone

    Pooled Library

    #1000000078

    Purpose

    Genome-wide CRISPR gRNA pooled library for activation of human genes

    Depositor

    Feng Zhang

    Available since

    June 27, 2016

    Availability

    Academic Institutions and Nonprofits only

12. hCRISPRa-v2, genome-wide, top 5 sgRNAs/gene

    Pooled Library

    #83978

    Purpose

    Version 2 of the human CRISPRa genome wide library

    Depositor

    Jonathan Weissman

    Article

    Horlbeck et al Elife. 2016 Sep 23;5. pii: e19760. doi:

    Use

    Lentiviral

    Available since

    Nov. 15, 2016

    Availability

    Academic Institutions and Nonprofits only

13. pMSCV-U6gRNA(lib)-PGKpuroT2ABFP library

    Pooled Library

    #104861

    Depositor

    Sarah Teichmann

    Article

    Henriksson et al Cell. 2019 Jan 7. pii: S0092-8674(18)315

    Available since

    Sept. 9, 2019

    Availability

    Academic Institutions and Nonprofits only

14. Bassik lab Mouse CRISPR-Cas9 Deletion Library - Membrane proteins

    Pooled Library

    #1000000124

    Purpose

    CRISPR gRNA mouse knockout pooled library - Membrane proteins

    Depositor

    Michael Bassik

    Available since

    May 23, 2018

    Availability

    Academic Institutions and Nonprofits only

15. Human ubiquitination-related proteins CRISPR KO library

    Pooled Library

    #174592

    Purpose

    CRISPR Cas9 KO library targets 660 ubiquitination-related proteins, including all major E1, E2, E3 and deubiquitinating enzymes, as well as other ubiquitination-related proteins.

    Depositor

    Juan Bonifacino

    Article

    Jia et al Elife. 2019 Nov 6;8. pii: 50034. doi: 10

    Expression

    Mammalian

    Species

    Homo sapiens

    Use

    CRISPR and Lentiviral

    Available since

    Nov. 30, 2021

    Availability

    Academic Institutions and Nonprofits only

16. SPLINTR mCHERRY v1

    Pooled Library

    #179775

    Purpose

    SPLINTR (Single-cell Profiling and LINeage TRacing) is a high diversity lentiviral barcode library for tracing clonal lineages using bulk and single-cell readouts.

    Depositor

    Mark Dawson

    Article

    Fennell et al Nature. 2022 Jan;601(7891):125-131. doi:

    Expression

    Mammalian

    Use

    Lentiviral

    Available since

    May 11, 2022

    Availability

    Academic Institutions and Nonprofits only

17. Human Brunello kinome pooled library, guides 1-4 in lentiCRISPRv2 backbone

    Pooled Library

    #75314

    Purpose

    Human sgRNA library in backbone lentiCRISPRv2 targeting 763 kinase genes and containing 3,052 unique sgRNAs along with 100 non-targeting controls

    Depositor

    David Root, John Doench

    Article

    Doench et al Nat Biotechnol. 2016 Jan 18. doi: 10.103

    Expression

    Mammalian

    Use

    CRISPR and Lentiviral

    Available since

    June 27, 2016

    Availability

    Academic Institutions and Nonprofits only

18. Human Brunello kinome pooled library, guides 1-8 in lentiCRISPRv2 backbone

    Pooled Library

    #1000000083

    Purpose

    CRISPR gRNA knockout pooled library for targeting the human kinome

    Depositor

    David Root, John Doench

    Available since

    June 27, 2016

    Availability

    Academic Institutions and Nonprofits only

19. Mouse lipid metabolism knockout library

    Pooled Library

    #206248

    Purpose

    The lipid metabolism library contains guide RNAs against 295 genes targeting mouse genes encoding enzymes that directly impact lipid metabolism.

    Depositor

    Kivanc Birsoy

    Article

    Soula et al Nature. 2024 Aug 7. doi: 10.1038/s41586-

    Use

    CRISPR and Lentiviral

    Available since

    Aug. 29, 2024

    Availability

    Academic Institutions and Nonprofits only

20. Inzolia library in pRDA_550

    Pooled Library

    #209552

    Purpose

    The human, genome-wide, CRISPR knockout enAsCas12a gRNA library targets single genes and paralog pairs, triples, and quads with arrays of 4 gRNAs.

    Depositor

    John Doench

    Article

    Esmaeili Anvar et al Nat Commun. 2024 Apr 27;15(1):3577. doi:

    Use

    CRISPR and Lentiviral

    Available since

    Dec. 5, 2023

    Availability

    Academic Institutions and Nonprofits only

21. Human sgRNA library Gattinara in pRDA_118 backbone

    Pooled Library

    #136986

    Purpose

    Expresses sgRNAs targeting human genes

    Depositor

    John Doench

    Article

    DeWeirdt et al Nat Commun. 2020 Feb 6;11(1):752. doi: 1

    Expression

    Mammalian

    Species

    Homo sapiens

    Use

    CRISPR and Lentiviral

    Available since

    Feb. 24, 2020

    Availability

    Academic Institutions and Nonprofits only

22. Bassik lab Mouse CRISPR-Cas9 Deletion Library - Drug targets, kinases, phosphatases

    Pooled Library

    #1000000122

    Purpose

    CRISPR gRNA mouse knockout pooled library - Drug targets, kinases, phosphatases

    Depositor

    Michael Bassik

    Available since

    May 23, 2018

    Availability

    Academic Institutions and Nonprofits only

23. Inzolia library in pRDA_052

    Pooled Library

    #209551

    Purpose

    The human, genome-wide, CRISPR knockout enAsCas12a gRNA library targets single genes and paralog pairs, triples, and quads with arrays of 4 gRNAs.

    Depositor

    John Doench

    Article

    Esmaeili Anvar et al Nat Commun. 2024 Apr 27;15(1):3577. doi:

    Use

    CRISPR and Lentiviral

    Available since

    Dec. 5, 2023

    Availability

    Academic Institutions and Nonprofits only

24. DNA repair library with 1,573 sgRNAs

    Pooled Library

    #177663

    Purpose

    CRISPR-interference (CRISPRi) library of 1,573 sgRNAs targeting 476 genes encoding factors involved in DNA repair and associated processes

    Depositor

    Brittany Adamson

    Article

    Hussmann et al Cell. 2021 Oct 28;184(22):5653-5669.e25.

    Species

    Homo sapiens

    Use

    CRISPR

    Available since

    July 11, 2023

    Availability

    Academic Institutions and Nonprofits only

25. pSMAL-CellTag-V2

    Pooled Library

    #115644

    Purpose

    Viral barcoding library to combinatorially index cells for single-cell analysis of clonal dynamics

    Depositor

    Samantha Morris

    Article

    Biddy et al Nature. 2018 Dec;564(7735):219-224. doi:

    Has Service

    Concentrated Lentiviral Prep

    Expression

    Mammalian

    Species

    Synthetic

    Use

    Lentiviral

    Available since

    Dec. 5, 2018

    Availability

    Academic Institutions and Nonprofits only

26. pSMAL-CellTag-V3

    Pooled Library

    #115645

    Purpose

    Viral barcoding library to combinatorially index cells for single-cell analysis of clonal dynamics

    Depositor

    Samantha Morris

    Article

    Biddy et al Nature. 2018 Dec;564(7735):219-224. doi:

    Has Service

    Concentrated Lentiviral Prep

    Expression

    Mammalian

    Species

    Synthetic

    Use

    Lentiviral

    Available since

    Dec. 5, 2018

    Availability

    Academic Institutions and Nonprofits only

27. Humagne Set C

    Pooled Library

    #172650

    Purpose

    Set C contains best-ranked guides 1 and 4.

    Depositor

    David Root, John Doench

    Article

    DeWeirdt et al Nat Biotechnol. 2020 Jul 13. pii: 10.103

    Expression

    Mammalian

    Available since

    Nov. 10, 2021

    Availability

    Academic Institutions and Nonprofits only

28. Human Metabolic Gene CRISPRa sgRNA library

    Pooled Library

    #187080

    Purpose

    Lentiviral CRISPRa library targeting human metabolic genes for activation of gene expression

    Depositor

    Kivanc Birsoy

    Article

    Unlu et al Mol Cell. 2022 Aug 4;82(15):2832-2843.e7

    Expression

    Mammalian

    Species

    Homo sapiens

    Use

    Lentiviral

    Available since

    Oct. 26, 2022

    Availability

    Academic Institutions and Nonprofits only

29. Pdest-EF1α-EGFP-32bp barcode polyA library

    Pooled Library

    #211610

    Purpose

    Barcoded retrovirus plasmid library for capturing the transcriptome and viral barcode sequences of individual cells to infer their identities and lineage information.

    Depositor

    Yuejun Chen

    Article

    You et al Cell Stem Cell. 2023 Apr 6;30(4):473-487

    Species

    Synthetic

    Use

    Retroviral

    Available since

    Aug. 29, 2024

    Availability

    Academic Institutions and Nonprofits only

30. Perturb-seq GBC library

    Pooled Library

    #85968

    Purpose

    Perturb-seq GBC library

    Depositor

    Jonathan Weissman

    Article

    Adamson et al Cell. 2016 Dec 15;167(7):1867-1882.e21.

    Expression

    Mammalian

    Use

    CRISPR and Lentiviral

    Available since

    Feb. 14, 2017

    Availability

    Academic Institutions and Nonprofits only

31. Mouse sphingolipid metabolism knockout library

    Pooled Library

    #206249

    Purpose

    The sphingolipid metabolism library targets 82 mouse genes in the de novo ceramide and downstream sphingolipid metabolism pathways.

    Depositor

    Kivanc Birsoy

    Article

    Soula et al Nature. 2024 Aug 7. doi: 10.1038/s41586-

    Use

    CRISPR and Lentiviral

    Available since

    Aug. 29, 2024

    Availability

    Academic Institutions and Nonprofits only

32. Lenti-human-UBDUB-gRNA-puromycin-IRES-CFP

    Pooled Library

    #171531

    Purpose

    Pooled gRNA library against human ubiquitination and de-ubiquitination complex genes (UBDUB)

    Depositor

    Chunliang Li

    Article

    Wright et al Proc Natl Acad Sci U S A. 2023 Apr 18;12

    Expression

    Mammalian

    Species

    Homo sapiens

    Use

    Lentiviral

    Available since

    June 22, 2021

    Availability

    Academic Institutions and Nonprofits only

33. Bassik lab Mouse CRISPR-Cas9 Deletion Library - Trafficking, mitochondrial, motility

    Pooled Library

    #1000000126

    Purpose

    CRISPR gRNA mouse knockout pooled library - Trafficking, mitochondrial, and motility

    Depositor

    Michael Bassik

    Available since

    May 23, 2018

    Availability

    Academic Institutions and Nonprofits only

34. Bassik lab Mouse CRISPR-Cas9 Deletion Library - Gene Expression

    Pooled Library

    #1000000123

    Purpose

    CRISPR gRNA mouse knockout pooled library - Gene expression

    Depositor

    Michael Bassik

    Available since

    May 23, 2018

    Availability

    Academic Institutions and Nonprofits only

35. Mouse Validation (mVAL) CRISPR Library

    Pooled Library

    #159391

    Purpose

    Pooled CRISPR library targets core intrinsic immune evasion genes

    Depositor

    Jason Moffat

    Article

    Lawson et al Nature. 2020 Oct;586(7827):120-126. doi:

    Expression

    Mammalian

    Species

    Mus musculus

    Use

    CRISPR and Lentiviral

    Available since

    Nov. 9, 2020

    Availability

    Academic Institutions and Nonprofits only

36. psgRNA Library

    Pooled Library

    #115927

    Purpose

    Genome-wide knockdown of E. coli genes

    Depositor

    David Bikard

    Article

    Cui et al Nat Commun. 2018 May 15;9(1):1912. doi:

    Expression

    Bacterial

    Species

    Escherichia coli

    Use

    CRISPR

    Available since

    June 6, 2019

    Availability

    Academic Institutions and Nonprofits only

37. Mouse messenger-RBP sgRNA library

    Pooled Library

    #169082

    Purpose

    CRISPR library targeting mouse genes

    Depositor

    Martin Turner

    Article

    Turner et al eLife. 2022 Apr 22;11. pii: 72313. doi:

    Expression

    Mammalian

    Species

    Mus musculus

    Use

    CRISPR and Lentiviral

    Available since

    Sept. 10, 2021

    Availability

    Academic Institutions and Nonprofits only

38. Bassik lab Mouse CRISPR-Cas9 Deletion Library - Apoptosis and cancer

    Pooled Library

    #1000000121

    Purpose

    CRISPR gRNA mouse knockout pooled library - Apoptosis and cancer

    Depositor

    Michael Bassik

    Available since

    May 23, 2018

    Availability

    Academic Institutions and Nonprofits only

39. Bassik lab Mouse CRISPR-Cas9 Deletion Library - Stress Proteostasis

    Pooled Library

    #1000000125

    Purpose

    CRISPR gRNA mouse knockout pooled library - Stress proteostasis

    Depositor

    Michael Bassik

    Available since

    May 23, 2018

    Availability

    Academic Institutions and Nonprofits only

40. Bassik lab Mouse CRISPR-Cas9 Deletion Library - Unassigned1

    Pooled Library

    #1000000127

    Purpose

    CRISPR gRNA mouse knockout pooled library - Unassigned1

    Depositor

    Michael Bassik

    Available since

    May 23, 2018

    Availability

    Academic Institutions and Nonprofits only