390 results

#79153

Library of protospacer flanking sites (PFS) inserted at the 5' end of the β-lactamase gene for screening PFS preference for Cas13a/C2c2.

Feng Zhang

Abudayyeh et al Science. 2016 Jun 2. pii: aaf5573.

Oct. 26, 2017

Academic Institutions and Nonprofits only

#217744

Targets 56 transcription factors in Yarrowia lipolytica, enabling the knockout or modulation of expression levels for these factors.

Irina Borodina

May 20, 2025

Academic Institutions and Nonprofits only

#199601

pRep-Cap SSM library enables VP1, VP2, and VP3 expression under the control of the endogenous p40 promoter

George Church

Ogden et al Science. 2019 Nov 29;366(6469):1139-1143

June 13, 2023

Academic Institutions and Nonprofits only

#51043

Sub-pool of Sabatini/Lander sgRNA library enriched for gene targets of unknown function.

Eric Lander, David Sabatini

Wang et al Science. 2014 Jan 3;343(6166):80-4. doi:

Feb. 7, 2014

Academic Institutions and Nonprofits only

#83986

Human CRISPRa Pooled Library targeting unassigned genes

Jonathan Weissman

Horlbeck et al Elife. 2016 Sep 23;5. pii: e19760. doi:

Jan. 12, 2017

Academic Institutions and Nonprofits only

#187248

Ultra-compact, human genome-wide CRISPRi library targeting each gene with a single element encoding a dual sgRNA cassette.

Marco Jost, Jonathan Weissman

Replogle et al eLife. 2022 Dec 28;11:e81856. doi: 10.75

Sept. 30, 2022

Academic Institutions and Nonprofits only

#1000000182

Jesse Bloom

June 14, 2022

Academic Institutions and Nonprofits only

#170432

Concise library targeting the whole genome of S. pneumoniae D39V with one sgRNA per operon or gene.

Jan-Willem Veening

Liu et al Cell Host Microbe. 2021 Jan 13;29(1):107

Aug. 31, 2021

Academic Institutions and Nonprofits only

#84001

Mouse CRISPRa Pooled Library targeting Mitochondria, Trafficking, and Motility genes

Jonathan Weissman

Horlbeck et al Elife. 2016 Sep 23;5. pii: e19760. doi:

Jan. 12, 2017

Academic Institutions and Nonprofits only

#179217

sgRNAs that target frequently occurring cancer associated mutations identified in the MSK IMPACT dataset that can be modeled with cytosine base editing.

Lukas Dow

Sanchez-Rivera et al Nat Biotechnol. 2022 Feb 14. pii: 10.103

June 16, 2022

Academic Institutions and Nonprofits only

#84004

Mouse CRISPRa Pooled Library targeting unassigned genes

Jonathan Weissman

Horlbeck et al Elife. 2016 Sep 23;5. pii: e19760. doi:

Jan. 12, 2017

Academic Institutions and Nonprofits only

#1000000172

Jesse Bloom

March 29, 2021

Academic Institutions and Nonprofits only

#182133

Knockout library targeting cancer-related genes.

Prashant Mali

Hu et al Biomaterials. 2022 Jan;280:121276. doi:

Aug. 26, 2022

Academic Institutions and Nonprofits only

#86543

Jonathan Weissman

Liu et al Science. 2017 Jan 06. Vol. 355, Issue 63

March 8, 2017

Academic Institutions and Nonprofits only

#82480

This library is intended to be used as a technical tool for removal of mitochondrial DNA from mouse genomic DNA preparations.

Wei Xie

Wu et al Nature. 2016 Jun 30;534(7609):652-7.

April 5, 2017

Academic Institutions and Nonprofits only

#113585

AAV-CRISPR library for pool mutagenesis of top tumor suppressor genes in mouse liver

Sidi Chen

Wang et al Sci Adv. 2018 Feb 28;4(2):eaao5508. doi:

July 23, 2019

Academic Institutions and Nonprofits only

#1000000181

Timothy Whitehead

June 21, 2022

Academic Institutions and Nonprofits only

#160135

Plasmid library harboring a randomized 10nt PAM 5’ of target site 4. Can be used to profile CRISPR-Cas PAM requirements of enzymes that recognize 5’ PAMs (e.g. Cas12a)

Keith Joung, Benjamin Kleinstiver

Walton et al Nat Protoc. 2021 Feb 5. pii: 10.1038/s41

Feb. 8, 2021

Academic Institutions and Nonprofits only

#1000000069

CRISPR gRNA knockout pooled library for targeting the human genome

Stephane Angers, Jason Moffat

Jan. 28, 2016

Academic Institutions and Nonprofits only

#198050

By supplying an AAV cap gene of interest in trans, researchers can use this library to investigate the effects of rep mutations on production of a wide range of AAV capsid serotypes

George Church

Jain et al Elife. 2024 Mar 27;12:RP87730. doi: 10.7

May 4, 2023

Academic Institutions and Nonprofits only

#75315

Human sgRNA library in backbone lentiCRISPRv2 targeting 763 kinase genes and containing 3,052 unique sgRNAs along with 100 non-targeting controls

John Doench, David Root

Doench et al Nat Biotechnol. 2016 Jan 18. doi: 10.103

June 27, 2016

Academic Institutions and Nonprofits only

#86550

Jonathan Weissman

Liu et al Science. 2017 Jan 06. Vol. 355, Issue 63

March 8, 2017

Academic Institutions and Nonprofits only

#86544

Jonathan Weissman

Liu et al Science. 2017 Jan 06. Vol. 355, Issue 63

March 8, 2017

Academic Institutions and Nonprofits only

#140633

Enables genome-wide CRISPR screening at high MOI through use of barcoded gRNA plasmids.

Wensheng Wei

Zhu et al Genome Biol. 2019 Jan 24;20(1):20. doi:

April 21, 2020

Academic Institutions and Nonprofits only

#86539

Jonathan Weissman

Liu et al Science. 2017 Jan 06. Vol. 355, Issue 63

March 8, 2017

Academic Institutions and Nonprofits only

#171172

Induces knockouts of paralogous gene pairs. Plasmids express a pair of guide RNAs targeting either individual genes or a pair of paralogs.

Alice Berger

Parrish et al Cell Rep. 2021 Aug 31;36(9):109597. doi:

Sept. 28, 2021

Academic Institutions and Nonprofits only

#1000000187

Jesse Bloom

June 14, 2022

Academic Institutions and Nonprofits only

#86541

Jonathan Weissman

Liu et al Science. 2017 Jan 06. Vol. 355, Issue 63

March 8, 2017

Academic Institutions and Nonprofits only

#160133

Plasmid library harboring a randomized 8nt PAM 3’ of target site 2. Can be used to profile CRISPR-Cas PAM requirements of enzymes that recognize 3’ PAMs (e.g. Cas9)

Keith Joung, Benjamin Kleinstiver

Walton et al Nat Protoc. 2021 Feb 5. pii: 10.1038/s41

Feb. 8, 2021

Academic Institutions and Nonprofits only

#187247

Ultra-compact, human genome-wide CRISPRi library targeting each gene with a single element encoding a dual sgRNA cassette.

Marco Jost, Jonathan Weissman

Replogle et al eLife. 2022 Dec 28;11:e81856. doi: 10.75

Sept. 30, 2022

Academic Institutions and Nonprofits only

#138015

AAV library targeting transcriptional regulators expressed in cardiomyocytes.

William Pu

VanDusen et al bioRxiv 2019, 808402v1; doi: https://doi

April 17, 2020

Academic Institutions and Nonprofits only

#86540

Jonathan Weissman

Liu et al Science. 2017 Jan 06. Vol. 355, Issue 63

March 8, 2017

Academic Institutions and Nonprofits only

#153101

CRISPR library targets all non-essential and conditionally essential transporter genes in S. cerevisiae

Irina Borodina

Wang et al Metab Eng. 2021 Jan 16. pii: S1096-7176(

Jan. 20, 2021

Academic Institutions and Nonprofits only

#1000000232

Tyler Starr

Oct. 25, 2023

Academic Institutions and Nonprofits only

#138084

Targets 3' splice sites with paired gRNAs. Induces skipping of poison cassette exons and matching upstream constitutive exons. Compare loss of a constitutive coding exon with loss of a poison exon.

Robert Bradley

Thomas et al Nat Genet. 2020 Jan;52(1):84-94. doi: 10

March 6, 2020

Academic Institutions and Nonprofits only

#216134

Library of intron-targeting sgRNAs for pooled tagging of proteins with GFP or other protein tags at their endogenous genomic locus using an intron tagging approach.

Stefan Kubicek

Reicher et al Nat Cell Biol. 2024 May;26(5):745-756. d

April 19, 2024

Academic Institutions and Nonprofits only

#216133

Library of intron-targeting sgRNAs for pooled tagging of proteins with GFP or other protein tags at their endogenous genomic locus using an intron tagging approach.

Stefan Kubicek

Reicher et al Nat Cell Biol. 2024 May;26(5):745-756. d

April 19, 2024

Academic Institutions and Nonprofits only

#92352

Focused gRNA library that targets synthetic lethal candidate and control genes with oncogenic Ras.

Eric Lander, David Sabatini

Wang et al Cell. 2017 Feb 1. pii: S0092-8674(17)300

June 7, 2017

Academic Institutions and Nonprofits only

#86542

Jonathan Weissman

Liu et al Science. 2017 Jan 06. Vol. 355, Issue 63

March 8, 2017

Academic Institutions and Nonprofits only

#1000000239

Jay Shendure

April 3, 2024

Academic Institutions and Nonprofits only