pCMV-dR8.2 dvpr Citations (471)
Originally described in: Lentivirus-delivered stable gene silencing by RNAi in primary cells.Stewart SA, Dykxhoorn DM, Palliser D, Mizuno H, Yu EY, An DS, Sabatini DM, Chen IS, Hahn WC, Sharp PA, Weinberg RA, Novina CD RNA 2003 Apr;9(4):493-501. PubMed Journal
Articles Citing pCMV-dR8.2 dvpr
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| Coactivation of janus tyrosine kinase (Jak)1 positively modulates prolactin-Jak2 signaling in breast cancer: recruitment of ERK and signal transducer and activator of transcription (Stat)3 and enhancement of Akt and Stat5a/b pathways. Neilson LM, Zhu J, Xie J, Malabarba MG, Sakamoto K, Wagner KU, Kirken RA, Rui H. Mol Endocrinol. 2007 Sep . 21(9):2218-32. PubMed |
| mTORC2 activity is elevated in gliomas and promotes growth and cell motility via overexpression of rictor. Masri J, Bernath A, Martin J, Jo OD, Vartanian R, Funk A, Gera J. Cancer Res. 2007 Dec 15. 67(24):11712-20. PubMed |
| Up-regulation of c-FLIP short by NFAT contributes to apoptosis resistance of short-term activated T cells. Ueffing N, Schuster M, Keil E, Schulze-Osthoff K, Schmitz I. Blood. 2008 Aug 1;112(3):690-8. doi: 10.1182/blood-2008-02-141382. Epub 2008 May 28. PubMed |
| Generation of human-induced pluripotent stem cells. Park IH, Lerou PH, Zhao R, Huo H, Daley GQ. Nat Protoc. 2008 . 3(7):1180-6. PubMed |
| XRCC1 protects against the lethality of induced oxidative DNA damage in nondividing neural cells. Kulkarni A, McNeill DR, Gleichmann M, Mattson MP, Wilson DM 3rd. Nucleic Acids Res. 2008 Sep;36(15):5111-21. doi: 10.1093/nar/gkn480. Epub 2008 Aug 5. PubMed |
| A myelopoiesis-associated regulatory intergenic noncoding RNA transcript within the human HOXA cluster. Zhang X, Lian Z, Padden C, Gerstein MB, Rozowsky J, Snyder M, Gingeras TR, Kapranov P, Weissman SM, Newburger PE. Blood. 2009 Mar 12;113(11):2526-34. doi: 10.1182/blood-2008-06-162164. Epub 2009 Jan 14. PubMed |
| Human iPS cell derivation/reprogramming. Park IH, Daley GQ. Curr Protoc Stem Cell Biol. 2009 Jan;Chapter 4:Unit 4A.1. doi: 10.1002/9780470151808.sc04a01s8. PubMed |
| The transcription of FOXO genes is stimulated by FOXO3 and repressed by growth factors. Essaghir A, Dif N, Marbehant CY, Coffer PJ, Demoulin JB. J Biol Chem. 2009 Apr 17;284(16):10334-42. doi: 10.1074/jbc.M808848200. Epub 2009 Feb 24. PubMed |
| Site-specific mTOR phosphorylation promotes mTORC1-mediated signaling and cell growth. Acosta-Jaquez HA, Keller JA, Foster KG, Ekim B, Soliman GA, Feener EP, Ballif BA, Fingar DC. Mol Cell Biol. 2009 Aug;29(15):4308-24. doi: 10.1128/MCB.01665-08. Epub 2009 Jun 1. PubMed |
| Conditional mouse lung cancer models using adenoviral or lentiviral delivery of Cre recombinase. DuPage M, Dooley AL, Jacks T. Nat Protoc. 2009;4(7):1064-72. doi: 10.1038/nprot.2009.95. Epub 2009 Jun 25. PubMed |
| Transforming growth-interacting factor (TGIF) regulates proliferation and differentiation of human myeloid leukemia cells. Hamid R, Brandt SJ. Mol Oncol. 2009 Dec;3(5-6):451-63. doi: 10.1016/j.molonc.2009.07.004. Epub 2009 Jul 29. PubMed |
| TAPP2 links phosphoinositide 3-kinase signaling to B-cell adhesion through interaction with the cytoskeletal protein utrophin: expression of a novel cell adhesion-promoting complex in B-cell leukemia. Costantini JL, Cheung SM, Hou S, Li H, Kung SK, Johnston JB, Wilkins JA, Gibson SB, Marshall AJ. Blood. 2009 Nov 19;114(21):4703-12. doi: 10.1182/blood-2009-03-213058. Epub 2009 Sep 28. PubMed |
| Developmental stages of the Japanese quail. Ainsworth SJ, Stanley RL, Evans DJ. J Anat. 2010 Jan;216(1):3-15. doi: 10.1111/j.1469-7580.2009.01173.x. Epub 2009 Nov 19. PubMed |
| Prolactin inhibits BCL6 expression in breast cancer through a Stat5a-dependent mechanism. Tran TH, Utama FE, Lin J, Yang N, Sjolund AB, Ryder A, Johnson KJ, Neilson LM, Liu C, Brill KL, Rosenberg AL, Witkiewicz AK, Rui H. Cancer Res. 2010 Feb 15;70(4):1711-21. doi: 10.1158/0008-5472.CAN-09-2314. Epub 2010 Feb 2. PubMed |
| Exploration of self-renewal and pluripotency in ES cells using RNAi. Schaniel C, Lee DF, Lemischka IR. Methods Enzymol. 2010;477:351-65. doi: 10.1016/S0076-6879(10)77018-X. PubMed |
| PTP1B suppresses prolactin activation of Stat5 in breast cancer cells. Johnson KJ, Peck AR, Liu C, Tran TH, Utama FE, Sjolund AB, Schaber JD, Witkiewicz AK, Rui H. Am J Pathol. 2010 Dec;177(6):2971-83. doi: 10.2353/ajpath.2010.090399. Epub 2010 Oct 15. PubMed |
Large intergenic non-coding RNA-RoR modulates reprogramming of human induced pluripotent stem cells.
Loewer S, Cabili MN, Guttman M, Loh YH, Thomas K, Park IH, Garber M, Curran M, Onder T, Agarwal S, Manos PD, Datta S, Lander ES, Schlaeger TM, Daley GQ, Rinn JL.
Nat Genet. 2010 Dec;42(12):1113-7. Epub 2010 Nov 7.
PubMed
Associated Plasmids |
| Therapy mediated by mitophagy abrogates tumor progression. Gargini R, Garcia-Escudero V, Izquierdo M. Autophagy. 2011 May;7(5):466-76. Epub 2011 May 1. PubMed |
| Checkpoint kinase 1 prevents cell cycle exit linked to terminal cell differentiation. Ullah Z, de Renty C, DePamphilis ML. Mol Cell Biol. 2011 Oct;31(19):4129-43. doi: 10.1128/MCB.05723-11. Epub 2011 Jul 26. PubMed |
| Growth differentiation factor 15 (GDF15)-mediated HER2 phosphorylation reduces trastuzumab sensitivity of HER2-overexpressing breast cancer cells. Joshi JP, Brown NE, Griner SE, Nahta R. Biochem Pharmacol. 2011 Nov 1;82(9):1090-9. doi: 10.1016/j.bcp.2011.07.082. Epub 2011 Jul 23. PubMed |
| Quantitative fluorescence imaging of protein diffusion and interaction in living cells. Capoulade J, Wachsmuth M, Hufnagel L, Knop M. Nat Biotechnol. 2011 Aug 7;29(9):835-9. doi: 10.1038/nbt.1928. PubMed |
| GADD45A protein plays an essential role in active DNA demethylation during terminal osteogenic differentiation of adipose-derived mesenchymal stem cells. Zhang RP, Shao JZ, Xiang LX. J Biol Chem. 2011 Nov 25;286(47):41083-94. doi: 10.1074/jbc.M111.258715. Epub 2011 Sep 14. PubMed |
| Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma. Landreville S, Agapova OA, Matatall KA, Kneass ZT, Onken MD, Lee RS, Bowcock AM, Harbour JW. Clin Cancer Res. 2012 Jan 15;18(2):408-16. doi: 10.1158/1078-0432.CCR-11-0946. Epub 2011 Oct 28. PubMed |
| Remodeling of the epitope repertoire of a candidate idiotype vaccine by targeting to lysosomal degradation in dendritic cells. Martorelli D, Coppotelli G, Muraro E, Dolcetti R, Masucci MG. Cancer Immunol Immunother. 2012 Jun;61(6):881-92. doi: 10.1007/s00262-011-1157-5. Epub 2011 Nov 17. PubMed |
| Ran is a potential therapeutic target for cancer cells with molecular changes associated with activation of the PI3K/Akt/mTORC1 and Ras/MEK/ERK pathways. Yuen HF, Chan KK, Grills C, Murray JT, Platt-Higgins A, Eldin OS, O'Byrne K, Janne P, Fennell DA, Johnston PG, Rudland PS, El-Tanani M. Clin Cancer Res. 2012 Jan 15;18(2):380-91. doi: 10.1158/1078-0432.CCR-11-2035. Epub 2011 Nov 16. PubMed |
| Synthesis of cytochrome C oxidase 2: a p53-dependent metabolic regulator that promotes respiratory function and protects glioma and colon cancer cells from hypoxia-induced cell death. Wanka C, Brucker DP, Bahr O, Ronellenfitsch M, Weller M, Steinbach JP, Rieger J. Oncogene. 2012 Aug 16;31(33):3764-76. doi: 10.1038/onc.2011.530. Epub 2011 Nov 28. PubMed |
| The role of c-FLIP splice variants in urothelial tumours. Ewald F, Ueffing N, Brockmann L, Hader C, Telieps T, Schuster M, Schulz WA, Schmitz I. Cell Death Dis. 2011 Dec 22;2:e245. doi: 10.1038/cddis.2011.131. PubMed |
| Peroxisome proliferator-activated receptor beta/delta induces myogenesis by modulating myostatin activity. Bonala S, Lokireddy S, Arigela H, Teng S, Wahli W, Sharma M, McFarlane C, Kambadur R. J Biol Chem. 2012 Apr 13;287(16):12935-51. doi: 10.1074/jbc.M111.319145. Epub 2012 Feb 23. PubMed |
| Combining competition assays with genetic complementation strategies to dissect mouse embryonic stem cell self-renewal and pluripotency. Lee DF, Su J, Sevilla A, Gingold J, Schaniel C, Lemischka IR. Nat Protoc. 2012 Mar 22;7(4):729-48. doi: 10.1038/nprot.2012.018. PubMed |
| The human RecQ helicases BLM and RECQL4 cooperate to preserve genome stability. Singh DK, Popuri V, Kulikowicz T, Shevelev I, Ghosh AK, Ramamoorthy M, Rossi ML, Janscak P, Croteau DL, Bohr VA. Nucleic Acids Res. 2012 Aug;40(14):6632-48. doi: 10.1093/nar/gks349. Epub 2012 Apr 28. PubMed |
| Excision of a viral reprogramming cassette by delivery of synthetic Cre mRNA. Loh YH, Yang JC, De Los Angeles A, Guo C, Cherry A, Rossi DJ, Park IH, Daley GQ. Curr Protoc Stem Cell Biol. 2012;Chapter 4:Unit4A.5. doi: 10.1002/9780470151808.sc04a05s21. PubMed |
| Maternal obesity downregulates microRNA let-7g expression, a possible mechanism for enhanced adipogenesis during ovine fetal skeletal muscle development. Yan X, Huang Y, Zhao JX, Rogers CJ, Zhu MJ, Ford SP, Nathanielsz PW, Du M. Int J Obes (Lond). 2013 Apr;37(4):568-75. doi: 10.1038/ijo.2012.69. Epub 2012 May 22. PubMed |
| gamma-Secretase inhibition promotes cell death, Noxa upregulation, and sensitization to BH3 mimetic ABT-737 in human breast cancer cells. Seveno C, Loussouarn D, Brechet S, Campone M, Juin P, Barille-Nion S. Breast Cancer Res. 2012 Jun 15;14(3):R96. PubMed |
| The extent of degeneration of cruciate ligament is associated with chondrogenic differentiation in patients with osteoarthritis of the knee. Kumagai K, Sakai K, Kusayama Y, Akamatsu Y, Sakamaki K, Morita S, Sasaki T, Saito T, Sakai T. Osteoarthritis Cartilage. 2012 Nov;20(11):1258-67. doi: 10.1016/j.joca.2012.07.013. Epub 2012 Jul 27. PubMed |
| Growth differentiation factor 15 stimulates rapamycin-sensitive ovarian cancer cell growth and invasion. Griner SE, Joshi JP, Nahta R. Biochem Pharmacol. 2013 Jan 1;85(1):46-58. doi: 10.1016/j.bcp.2012.10.007. Epub 2012 Oct 17. PubMed |
| Loss of NF1 expression in human endothelial cells promotes autonomous proliferation and altered vascular morphogenesis. Bajaj A, Li QF, Zheng Q, Pumiglia K. PLoS One. 2012;7(11):e49222. doi: 10.1371/journal.pone.0049222. Epub 2012 Nov 7. PubMed |
| Phytochemicals attenuating aberrant activation of beta-catenin in cancer cells. Wang D, Wise ML, Li F, Dey M. PLoS One. 2012;7(12):e50508. doi: 10.1371/journal.pone.0050508. Epub 2012 Dec 3. PubMed |
| High-mobility group box 2 (HMGB2) modulates radioresponse and is downregulated by p53 in colorectal cancer cell. Shin YJ, Kim MS, Kim MS, Lee J, Kang M, Jeong JH. Cancer Biol Ther. 2013 Mar;14(3):213-21. doi: 10.4161/cbt.23292. Epub 2012 Dec 19. PubMed |
| On-target JAK2/STAT3 inhibition slows disease progression in orthotopic xenografts of human glioblastoma brain tumor stem cells. Stechishin OD, Luchman HA, Ruan Y, Blough MD, Nguyen SA, Kelly JJ, Cairncross JG, Weiss S. Neuro Oncol. 2013 Feb;15(2):198-207. doi: 10.1093/neuonc/nos302. Epub 2012 Dec 21. PubMed |
| Rapamycin-treated human endothelial cells preferentially activate allogeneic regulatory T cells. Wang C, Yi T, Qin L, Maldonado RA, von Andrian UH, Kulkarni S, Tellides G, Pober JS. J Clin Invest. 2013 Apr;123(4):1677-93. doi: 10.1172/JCI66204. Epub 2013 Mar 8. PubMed |
| Rap2b, a novel p53 target, regulates p53-mediated pro-survival function. Zhang X, He Y, Lee KH, Dubois W, Li Z, Wu X, Kovalchuk A, Zhang W, Huang J. Cell Cycle. 2013 Apr 15;12(8):1279-91. doi: 10.4161/cc.24364. Epub 2013 Mar 27. PubMed |
| Pseudovirus-based neuraminidase inhibition assays reveal potential H5N1 drug-resistant mutations. Lu Y, Jiang T. Protein Cell. 2013 May;4(5):356-63. doi: 10.1007/s13238-013-2125-y. Epub 2013 Apr 15. PubMed |
| Evidence for tankyrases as antineoplastic targets in lung cancer. Busch AM, Johnson KC, Stan RV, Sanglikar A, Ahmed Y, Dmitrovsky E, Freemantle SJ. BMC Cancer. 2013 Apr 28;13:211. doi: 10.1186/1471-2407-13-211. PubMed |
| The RecQ helicase RECQL5 participates in psoralen-induced interstrand cross-link repair. Ramamoorthy M, May A, Tadokoro T, Popuri V, Seidman MM, Croteau DL, Bohr VA. Carcinogenesis. 2013 Oct;34(10):2218-30. doi: 10.1093/carcin/bgt183. Epub 2013 May 28. PubMed |
| Fine time course expression analysis identifies cascades of activation and repression and maps a putative regulator of mammalian sex determination. Munger SC, Natarajan A, Looger LL, Ohler U, Capel B. PLoS Genet. 2013;9(7):e1003630. doi: 10.1371/journal.pgen.1003630. Epub 2013 Jul 11. PubMed |
| BAP1 deficiency causes loss of melanocytic cell identity in uveal melanoma. Matatall KA, Agapova OA, Onken MD, Worley LA, Bowcock AM, Harbour JW. BMC Cancer. 2013 Aug 5;13:371. doi: 10.1186/1471-2407-13-371. PubMed |
| Generation of porcine induced pluripotent stem cells and evaluation of their major histocompatibility complex protein expression in vitro. Park KM, Cha SH, Ahn C, Woo HM. Vet Res Commun. 2013 Dec;37(4):293-301. doi: 10.1007/s11259-013-9574-x. Epub 2013 Aug 23. PubMed |
| Acidosis decreases c-Myc oncogene expression in human lymphoma cells: a role for the proton-sensing G protein-coupled receptor TDAG8. Li Z, Dong L, Dean E, Yang LV. Int J Mol Sci. 2013 Oct 11;14(10):20236-55. doi: 10.3390/ijms141020236. PubMed |
| PRDM14 promotes active DNA demethylation through the ten-eleven translocation (TET)-mediated base excision repair pathway in embryonic stem cells. Okashita N, Kumaki Y, Ebi K, Nishi M, Okamoto Y, Nakayama M, Hashimoto S, Nakamura T, Sugasawa K, Kojima N, Takada T, Okano M, Seki Y. Development. 2014 Jan;141(2):269-80. doi: 10.1242/dev.099622. Epub 2013 Dec 11. PubMed |
| TGF-beta receptor type-2 expression in cancer-associated fibroblasts regulates breast cancer cell growth and survival and is a prognostic marker in pre-menopausal breast cancer. Busch S, Acar A, Magnusson Y, Gregersson P, Ryden L, Landberg G. Oncogene. 2015 Jan 2;34(1):27-38. doi: 10.1038/onc.2013.527. Epub 2013 Dec 16. PubMed |
| Myostatin induces insulin resistance via Casitas B-lineage lymphoma b (Cblb)-mediated degradation of insulin receptor substrate 1 (IRS1) protein in response to high calorie diet intake. Bonala S, Lokireddy S, McFarlane C, Patnam S, Sharma M, Kambadur R. J Biol Chem. 2014 Mar 14;289(11):7654-70. doi: 10.1074/jbc.M113.529925. Epub 2014 Jan 22. PubMed |
| All-trans-retinoic acid antagonizes the Hedgehog pathway by inducing patched. Busch AM, Galimberti F, Nehls KE, Roengvoraphoj M, Sekula D, Li B, Guo Y, Direnzo J, Fiering SN, Spinella MJ, Robbins DJ, Memoli VA, Freemantle SJ, Dmitrovsky E. Cancer Biol Ther. 2014 Apr;15(4):463-72. doi: 10.4161/cbt.27821. Epub 2014 Feb 4. PubMed |
| Rapamycin antagonizes TNF induction of VCAM-1 on endothelial cells by inhibiting mTORC2. Wang C, Qin L, Manes TD, Kirkiles-Smith NC, Tellides G, Pober JS. J Exp Med. 2014 Mar 10;211(3):395-404. doi: 10.1084/jem.20131125. Epub 2014 Feb 10. PubMed |
| Epstein-Barr virus utilizes Ikaros in regulating its latent-lytic switch in B cells. Iempridee T, Reusch JA, Riching A, Johannsen EC, Dovat S, Kenney SC, Mertz JE. J Virol. 2014 May;88(9):4811-27. doi: 10.1128/JVI.03706-13. Epub 2014 Feb 12. PubMed |
Anoctamin 6 regulates C2C12 myoblast proliferation.
Zhao P, Torcaso A, Mariano A, Xu L, Mohsin S, Zhao L, Han R.
PLoS One. 2014 Mar 24;9(3):e92749. doi: 10.1371/journal.pone.0092749. eCollection 2014.
PubMed
Associated Plasmids |
| Regulation of fibulin-2 gene expression by integrin alpha3beta1 contributes to the invasive phenotype of transformed keratinocytes. Missan DS, Chittur SV, DiPersio CM. J Invest Dermatol. 2014 Sep;134(9):2418-27. doi: 10.1038/jid.2014.166. Epub 2014 Apr 2. PubMed |
| Hypoxia enhances the antiglioma cytotoxicity of B10, a glycosylated derivative of betulinic acid. Fischer S, Ronellenfitsch MW, Thiepold AL, Harter PN, Reichert S, Kogel D, Paschke R, Mittelbronn M, Weller M, Steinbach JP, Fulda S, Bahr O. PLoS One. 2014 Apr 17;9(4):e94921. doi: 10.1371/journal.pone.0094921. eCollection 2014. PubMed |
| Capsaicin treatment attenuates cholangiocarcinoma carcinogenesis. Wutka A, Palagani V, Barat S, Chen X, El Khatib M, Gotze J, Belahmer H, Zender S, Bozko P, Malek NP, Plentz RR. PLoS One. 2014 Apr 18;9(4):e95605. doi: 10.1371/journal.pone.0095605. eCollection 2014. PubMed |
AP1S3 mutations are associated with pustular psoriasis and impaired Toll-like receptor 3 trafficking.
Setta-Kaffetzi N, Simpson MA, Navarini AA, Patel VM, Lu HC, Allen MH, Duckworth M, Bachelez H, Burden AD, Choon SE, Griffiths CE, Kirby B, Kolios A, Seyger MM, Prins C, Smahi A, Trembath RC, Fraternali F, Smith CH, Barker JN, Capon F.
Am J Hum Genet. 2014 May 1;94(5):790-7. doi: 10.1016/j.ajhg.2014.04.005.
PubMed
Associated Plasmids |
| Dissecting engineered cell types and enhancing cell fate conversion via CellNet. Morris SA, Cahan P, Li H, Zhao AM, San Roman AK, Shivdasani RA, Collins JJ, Daley GQ. Cell. 2014 Aug 14;158(4):889-902. doi: 10.1016/j.cell.2014.07.021. PubMed |
| Label-free, live optical imaging of reprogrammed bipolar disorder patient-derived cells reveals a functional correlate of lithium responsiveness. Wang JL, Shamah SM, Sun AX, Waldman ID, Haggarty SJ, Perlis RH. Transl Psychiatry. 2014 Aug 26;4:e428. doi: 10.1038/tp.2014.72. PubMed |
| Kruppel-like factor 6 interferes with cellular transformation induced by the H-ras oncogene. Trucco LD, Andreoli V, Nunez NG, Maccioni M, Bocco JL. FASEB J. 2014 Dec;28(12):5262-76. doi: 10.1096/fj.14-251884. Epub 2014 Sep 11. PubMed |
| PDGF-D expression is down-regulated by TGFbeta in fibroblasts. Charni Chaabane S, Coomans de Brachene A, Essaghir A, Velghe A, Lo Re S, Stockis J, Lucas S, Khachigian LM, Huaux F, Demoulin JB. PLoS One. 2014 Oct 3;9(10):e108656. doi: 10.1371/journal.pone.0108656. eCollection 2014. PubMed |
A platform for rapid prototyping of synthetic gene networks in mammalian cells.
Duportet X, Wroblewska L, Guye P, Li Y, Eyquem J, Rieders J, Rimchala T, Batt G, Weiss R.
Nucleic Acids Res. 2014 Dec 1;42(21):13440-51. doi: 10.1093/nar/gku1082. Epub 2014 Nov 5.
PubMed
Associated Plasmids |
| Cellular differentiation regulator BLIMP1 induces Epstein-Barr virus lytic reactivation in epithelial and B cells by activating transcription from both the R and Z promoters. Reusch JA, Nawandar DM, Wright KL, Kenney SC, Mertz JE. J Virol. 2015 Feb;89(3):1731-43. doi: 10.1128/JVI.02781-14. Epub 2014 Nov 19. PubMed |
| RSPO2 Enhances Canonical Wnt Signaling to Confer Stemness-Associated Traits to Susceptible Pancreatic Cancer Cells. Ilmer M, Boiles AR, Regel I, Yokoi K, Michalski CW, Wistuba II, Rodriguez J, Alt E, Vykoukal J. Cancer Res. 2015 May 1;75(9):1883-96. doi: 10.1158/0008-5472.CAN-14-1327. Epub 2015 Mar 13. PubMed |
| A Proteomic Strategy Identifies Lysine Methylation of Splicing Factor snRNP70 by the SETMAR Enzyme. Carlson SM, Moore KE, Sankaran SM, Reynoird N, Elias JE, Gozani O. J Biol Chem. 2015 May 8;290(19):12040-7. doi: 10.1074/jbc.M115.641530. Epub 2015 Mar 20. PubMed |
| Loss of TGFbeta Receptor Type 2 Expression Impairs Estrogen Response and Confers Tamoxifen Resistance. Busch S, Sims AH, Stal O, Ferno M, Landberg G. Cancer Res. 2015 Apr 1;75(7):1457-69. doi: 10.1158/0008-5472.CAN-14-1583. PubMed |
| Proteasome inhibition enhances the killing effect of BikDD gene therapy. Sun Y, Ponz-Sarvise M, Chang SS, Chang WC, Chen CH, Hsu JL, Hung MC. Am J Transl Res. 2015 Feb 15;7(2):319-27. eCollection 2015. PubMed |
| MALT1 is required for EGFR-induced NF-kappaB activation and contributes to EGFR-driven lung cancer progression. Pan D, Jiang C, Ma Z, Blonska M, You MJ, Lin X. Oncogene. 2015 May 18. doi: 10.1038/onc.2015.146. PubMed |
TRAFD1 (FLN29) Interacts with Plekhm1 and Regulates Osteoclast Acidification and Resorption.
Witwicka H, Jia H, Kutikov A, Reyes-Gutierrez P, Li X, Odgren PR.
PLoS One. 2015 May 19;10(5):e0127537. doi: 10.1371/journal.pone.0127537. eCollection 2015.
PubMed
Associated Plasmids |
| Coronary Artery Disease Associated Transcription Factor TCF21 Regulates Smooth Muscle Precursor Cells That Contribute to the Fibrous Cap. Nurnberg ST, Cheng K, Raiesdana A, Kundu R, Miller CL, Kim JB, Arora K, Carcamo-Oribe I, Xiong Y, Tellakula N, Nanda V, Murthy N, Boisvert WA, Hedin U, Perisic L, Aldi S, Maegdefessel L, Pjanic M, Owens GK, Tallquist MD, Quertermous T. PLoS Genet. 2015 May 28;11(5):e1005155. doi: 10.1371/journal.pgen.1005155. eCollection 2015 May. PubMed |
| Cardiospecific CD36 suppression by lentivirus-mediated RNA interference prevents cardiac hypertrophy and systolic dysfunction in high-fat-diet induced obese mice. Zhang Y, Bao M, Dai M, Wang X, He W, Tan T, Lin D, Wang W, Wen Y, Zhang R. Cardiovasc Diabetol. 2015 Jun 3;14:69. doi: 10.1186/s12933-015-0234-z. PubMed |
| Tumors escape CD4+ T cell-mediated immunosurveillance by impairing the ability of infiltrating macrophages to indirectly present tumor antigens. Tveita AA, Schjesvold F, Haabeth OA, Fauskanger MH, Bogen B. Cancer Res. 2015 Jun 2. pii: canres.3640.2014. PubMed |
| A Novel Role of E-Cadherin-Based Adherens Junctions in Neoplastic Cell Dissemination. Rubtsova SN, Zhitnyak IY, Gloushankova NA. PLoS One. 2015 Jul 24;10(7):e0133578. doi: 10.1371/journal.pone.0133578. eCollection 2015. PubMed |
| Heat shock factor 1 induces cancer stem cell phenotype in breast cancer cell lines. Wang B, Lee CW, Witt A, Thakkar A, Ince TA. Breast Cancer Res Treat. 2015 Aug;153(1):57-66. doi: 10.1007/s10549-015-3521-1. Epub 2015 Jul 30. PubMed |
Mammalian synthetic circuits with RNA binding proteins for RNA-only delivery.
Wroblewska L, Kitada T, Endo K, Siciliano V, Stillo B, Saito H, Weiss R.
Nat Biotechnol. 2015 Aug 3. doi: 10.1038/nbt.3301.
PubMed
Associated Plasmids |
| Inhibition of adipose triglyceride lipase (ATGL) by the putative tumor suppressor G0S2 or a small molecule inhibitor attenuates the growth of cancer cells. Zagani R, El-Assaad W, Gamache I, Teodoro JG. Oncotarget. 2015 Sep 29;6(29):28282-95. doi: 10.18632/oncotarget.5061. PubMed |
| The Deleted in Liver Cancer 1 (Dlc1) tumor suppressor is haploinsufficient for mammary gland development and epithelial cell polarity. Basak P, Dillon R, Leslie H, Raouf A, Mowat MR. BMC Cancer. 2015 Sep 9;15:630. doi: 10.1186/s12885-015-1642-x. PubMed |
| miR-128 represses L1 retrotransposition by binding directly to L1 RNA. Hamdorf M, Idica A, Zisoulis DG, Gamelin L, Martin C, Sanders KJ, Pedersen IM. Nat Struct Mol Biol. 2015 Oct;22(10):824-31. doi: 10.1038/nsmb.3090. Epub 2015 Sep 14. PubMed |
| Expression profiling of in vivo ductal carcinoma in situ progression models identified B cell lymphoma-9 as a molecular driver of breast cancer invasion. Elsarraj HS, Hong Y, Valdez KE, Michaels W, Hook M, Smith WP, Chien J, Herschkowitz JI, Troester MA, Beck M, Inciardi M, Gatewood J, May L, Cusick T, McGinness M, Ricci L, Fan F, Tawfik O, Marks JR, Knapp JR, Yeh HW, Thomas P, Carrasco DR, Fields TA, Godwin AK, Behbod F. Breast Cancer Res. 2015 Sep 17;17:128. doi: 10.1186/s13058-015-0630-z. PubMed |
| SLUG is required for SOX9 stabilization and functions to promote cancer stem cells and metastasis in human lung carcinoma. Luanpitpong S, Li J, Manke A, Brundage K, Ellis E, McLaughlin SL, Angsutararux P, Chanthra N, Voronkova M, Chen YC, Wang L, Chanvorachote P, Pei M, Issaragrisil S, Rojanasakul Y. Oncogene. 2015 Sep 21. doi: 10.1038/onc.2015.351. PubMed |
| Histone Deacetylase 3 Coordinates Deacetylase-independent Epigenetic Silencing of Transforming Growth Factor-beta1 (TGF-beta1) to Orchestrate Second Heart Field Development. Lewandowski SL, Janardhan HP, Trivedi CM. J Biol Chem. 2015 Nov 6;290(45):27067-89. doi: 10.1074/jbc.M115.684753. Epub 2015 Sep 29. PubMed |
| NRF2 regulates serine biosynthesis in non-small cell lung cancer. DeNicola GM, Chen PH, Mullarky E, Sudderth JA, Hu Z, Wu D, Tang H, Xie Y, Asara JM, Huffman KE, Wistuba II, Minna JD, DeBerardinis RJ, Cantley LC. Nat Genet. 2015 Dec;47(12):1475-81. doi: 10.1038/ng.3421. Epub 2015 Oct 19. PubMed |
| CRISPR Technology for Genome Activation and Repression in Mammalian Cells. Du D, Qi LS. Cold Spring Harb Protoc. 2016 Jan 4;2016(1):pdb.prot090175. doi: 10.1101/pdb.prot090175. PubMed |
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| Structural Definition of a Neutralization-Sensitive Epitope on the MERS-CoV S1-NTD. Wang N, Rosen O, Wang L, Turner HL, Stevens LJ, Corbett KS, Bowman CA, Pallesen J, Shi W, Zhang Y, Leung K, Kirchdoerfer RN, Becker MM, Denison MR, Chappell JD, Ward AB, Graham BS, McLellan JS. Cell Rep. 2019 Sep 24;28(13):3395-3405.e6. doi: 10.1016/j.celrep.2019.08.052. PubMed |
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| CRISPR/Cas9-Based Genetic Screening to Study T-Cell Function. Shang W, Wang F, Zhu Q, Wang L, Wang H. Methods Mol Biol. 2020;2111:59-70. doi: 10.1007/978-1-0716-0266-9_5. PubMed |
| Zika Virus Targets Glioblastoma Stem Cells through a SOX2-Integrin alpha(v)beta(5) Axis. Zhu Z, Mesci P, Bernatchez JA, Gimple RC, Wang X, Schafer ST, Wettersten HI, Beck S, Clark AE, Wu Q, Prager BC, Kim LJY, Dhanwani R, Sharma S, Garancher A, Weis SM, Mack SC, Negraes PD, Trujillo CA, Penalva LO, Feng J, Lan Z, Zhang R, Wessel AW, Dhawan S, Diamond MS, Chen CC, Wechsler-Reya RJ, Gage FH, Hu H, Siqueira-Neto JL, Muotri AR, Cheresh DA, Rich JN. Cell Stem Cell. 2020 Feb 6;26(2):187-204.e10. doi: 10.1016/j.stem.2019.11.016. Epub 2020 Jan 16. PubMed |
p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis.
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| p53 controls genomic stability and temporal differentiation of human neural stem cells and affects neural organization in human brain organoids. Marin Navarro A, Pronk RJ, van der Geest AT, Oliynyk G, Nordgren A, Arsenian-Henriksson M, Falk A, Wilhelm M. Cell Death Dis. 2020 Jan 23;11(1):52. doi: 10.1038/s41419-019-2208-7. PubMed |
| Imprinted Maternally Expressed microRNAs Antagonize Paternally Driven Gene Programs in Neurons. Whipple AJ, Breton-Provencher V, Jacobs HN, Chitta UK, Sur M, Sharp PA. Mol Cell. 2020 Apr 2;78(1):85-95.e8. doi: 10.1016/j.molcel.2020.01.020. Epub 2020 Feb 6. PubMed |
| The ACSL3-LPIAT1 signaling drives prostaglandin synthesis in non-small cell lung cancer. Saliakoura M, Reynoso-Moreno I, Pozzato C, Rossi Sebastiano M, Galie M, Gertsch J, Konstantinidou G. Oncogene. 2020 Apr;39(14):2948-2960. doi: 10.1038/s41388-020-1196-5. Epub 2020 Feb 7. PubMed |
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| JC Virus infected choroid plexus epithelial cells produce extracellular vesicles that infect glial cells independently of the virus attachment receptor. O'Hara BA, Morris-Love J, Gee GV, Haley SA, Atwood WJ. PLoS Pathog. 2020 Mar 4;16(3):e1008371. doi: 10.1371/journal.ppat.1008371. eCollection 2020 Mar. PubMed |
| Nicotinamide nucleotide transhydrogenase regulates mitochondrial metabolism in NSCLC through maintenance of Fe-S protein function. Ward NP, Kang YP, Falzone A, Boyle TA, DeNicola GM. J Exp Med. 2020 Jun 1;217(6). pii: 151572. doi: 10.1084/jem.20191689. PubMed |
| Smooth Muscle Cell Reprogramming in Aortic Aneurysms. Chen PY, Qin L, Li G, Malagon-Lopez J, Wang Z, Bergaya S, Gujja S, Caulk AW, Murtada SI, Zhang X, Zhuang ZW, Rao DA, Wang G, Tobiasova Z, Jiang B, Montgomery RR, Sun L, Sun H, Fisher EA, Gulcher JR, Fernandez-Hernando C, Humphrey JD, Tellides G, Chittenden TW, Simons M. Cell Stem Cell. 2020 Apr 2;26(4):542-557.e11. doi: 10.1016/j.stem.2020.02.013. PubMed |
| Inhibition of collagen XI alpha 1-induced fatty acid oxidation triggers apoptotic cell death in cisplatin-resistant ovarian cancer. Nallanthighal S, Rada M, Heiserman JP, Cha J, Sage J, Zhou B, Yang W, Hu Y, Korgaonkar C, Hanos CT, Ashkavand Z, Norman K, Orsulic S, Cheon DJ. Cell Death Dis. 2020 Apr 20;11(4):258. doi: 10.1038/s41419-020-2442-z. PubMed |
| Trichoplein binds PCM1 and controls endothelial cell function by regulating autophagy. Martello A, Lauriola A, Mellis D, Parish E, Dawson JC, Imrie L, Vidmar M, Gammoh N, Mitic T, Brittan M, Mills NL, Carragher NO, D'Arca D, Caporali A. EMBO Rep. 2020 Jul 3;21(7):e48192. doi: 10.15252/embr.201948192. Epub 2020 Apr 26. PubMed |
| Nelfinavir Inhibits the TCF11/Nrf1-Mediated Proteasome Recovery Pathway in Multiple Myeloma. Fassmannova D, Sedlak F, Sedlacek J, Spicka I, Grantz Saskova K. Cancers (Basel). 2020 Apr 25;12(5). pii: cancers12051065. doi: 10.3390/cancers12051065. PubMed |
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| Photoactivatable Cre recombinase 3.0 for in vivo mouse applications. Morikawa K, Furuhashi K, de Sena-Tomas C, Garcia-Garcia AL, Bekdash R, Klein AD, Gallerani N, Yamamoto HE, Park SE, Collins GS, Kawano F, Sato M, Lin CS, Targoff KL, Au E, Salling MC, Yazawa M. Nat Commun. 2020 May 1;11(1):2141. doi: 10.1038/s41467-020-16030-0. PubMed |
| SETD5-Coordinated Chromatin Reprogramming Regulates Adaptive Resistance to Targeted Pancreatic Cancer Therapy. Wang Z, Hausmann S, Lyu R, Li TM, Lofgren SM, Flores NM, Fuentes ME, Caporicci M, Yang Z, Meiners MJ, Cheek MA, Howard SA, Zhang L, Elias JE, Kim MP, Maitra A, Wang H, Bassik MC, Keogh MC, Sage J, Gozani O, Mazur PK. Cancer Cell. 2020 Jun 8;37(6):834-849.e13. doi: 10.1016/j.ccell.2020.04.014. Epub 2020 May 21. PubMed |
| MYC Drives Temporal Evolution of Small Cell Lung Cancer Subtypes by Reprogramming Neuroendocrine Fate. Ireland AS, Micinski AM, Kastner DW, Guo B, Wait SJ, Spainhower KB, Conley CC, Chen OS, Guthrie MR, Soltero D, Qiao Y, Huang X, Tarapcsak S, Devarakonda S, Chalishazar MD, Gertz J, Moser JC, Marth G, Puri S, Witt BL, Spike BT, Oliver TG. Cancer Cell. 2020 Jul 13;38(1):60-78.e12. doi: 10.1016/j.ccell.2020.05.001. Epub 2020 May 30. PubMed |
| Mitochondrial AIF loss causes metabolic reprogramming, caspase-independent cell death blockade, embryonic lethality, and perinatal hydrocephalus. Delavallee L, Mathiah N, Cabon L, Mazeraud A, Brunelle-Navas MN, Lerner LK, Tannoury M, Prola A, Moreno-Loshuertos R, Baritaud M, Vela L, Garbin K, Garnier D, Lemaire C, Langa-Vives F, Cohen-Salmon M, Fernandez-Silva P, Chretien F, Migeotte I, Susin SA. Mol Metab. 2020 May 30;40:101027. doi: 10.1016/j.molmet.2020.101027. PubMed |
| Abrogation of PRRSV infectivity by CRISPR-Cas13b-mediated viral RNA cleavage in mammalian cells. Cui J, Techakriengkrai N, Nedumpun T, Suradhat S. Sci Rep. 2020 Jun 15;10(1):9617. doi: 10.1038/s41598-020-66775-3. PubMed |
| PHGDH supports liver ceramide synthesis and sustains lipid homeostasis. Kang YP, Falzone A, Liu M, Gonzalez-Sanchez P, Choi BH, Coloff JL, Saller JJ, Karreth FA, DeNicola GM. Cancer Metab. 2020 Jun 15;8:6. doi: 10.1186/s40170-020-00212-x. eCollection 2020. PubMed |
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| A Contaminant Impurity, Not Rigosertib, Is a Tubulin Binding Agent. Baker SJ, Cosenza SC, Athuluri-Divakar S, Reddy MVR, Vasquez-Del Carpio R, Jain R, Aggarwal AK, Reddy EP. Mol Cell. 2020 Jul 2;79(1):180-190.e4. doi: 10.1016/j.molcel.2020.05.024. PubMed |
| Cancer Stem Cell-Inducing Media Activates Senescence Reprogramming in Fibroblasts. Perrigue PM, Rakoczy M, Pawlicka KP, Belter A, Giel-Pietraszuk M, Naskret-Barciszewska M, Barciszewski J, Figlerowicz M. Cancers (Basel). 2020 Jun 30;12(7). pii: cancers12071745. doi: 10.3390/cancers12071745. PubMed |
| MEIS1 down-regulation by MYC mediates prostate cancer development through elevated HOXB13 expression and AR activity. Whitlock NC, Trostel SY, Wilkinson S, Terrigino NT, Hennigan ST, Lake R, Carrabba NV, Atway R, Walton ED, Gryder BE, Capaldo BJ, Ye H, Sowalsky AG. Oncogene. 2020 Aug;39(34):5663-5674. doi: 10.1038/s41388-020-01389-7. Epub 2020 Jul 17. PubMed |
| Chimeric Antigen Receptor Designed to Prevent Ubiquitination and Downregulation Showed Durable Antitumor Efficacy. Li W, Qiu S, Chen J, Jiang S, Chen W, Jiang J, Wang F, Si W, Shu Y, Wei P, Fan G, Tian R, Wu H, Xu C, Wang H. Immunity. 2020 Aug 18;53(2):456-470.e6. doi: 10.1016/j.immuni.2020.07.011. Epub 2020 Aug 5. PubMed |
CD47 Ligation Repositions the Inhibitory Receptor SIRPA to Suppress Integrin Activation and Phagocytosis.
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Immunity. 2020 Aug 18;53(2):290-302.e6. doi: 10.1016/j.immuni.2020.07.008. Epub 2020 Aug 7.
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| SUMOylation of E2F1 Regulates Expression of EZH2. Du L, Fakih MG, Rosen ST, Chen Y. Cancer Res. 2020 Oct 1;80(19):4212-4223. doi: 10.1158/0008-5472.CAN-20-1259. Epub 2020 Aug 14. PubMed |
An alpaca nanobody neutralizes SARS-CoV-2 by blocking receptor interaction.
Hanke L, Vidakovics Perez L, Sheward DJ, Das H, Schulte T, Moliner-Morro A, Corcoran M, Achour A, Karlsson Hedestam GB, Hallberg BM, Murrell B, McInerney GM.
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| Tumor suppressive function of Matrin 3 in the basal-like breast cancer. Yang J, Lee SJ, Kwon Y, Ma L, Kim J. Biol Res. 2020 Sep 25;53(1):42. doi: 10.1186/s40659-020-00310-6. PubMed |
| PLCgamma1 suppression promotes the adaptation of KRAS-mutant lung adenocarcinomas to hypoxia. Saliakoura M, Rossi Sebastiano M, Pozzato C, Heidel FH, Schnoder TM, Savic Prince S, Bubendorf L, Pinton P, A Schmid R, Baumgartner J, Freigang S, Berezowska SA, Rimessi A, Konstantinidou G. Nat Cell Biol. 2020 Nov;22(11):1382-1395. doi: 10.1038/s41556-020-00592-8. Epub 2020 Oct 19. PubMed |
| Cetuximab-Mediated Protection from Hypoxia- Induced Cell Death: Implications for Therapy Sequence in Colorectal Cancer. Urban H, Maurer GD, Luger AL, Lorenz NI, Sauer B, Stroh C, Trojan J, Mittelbronn M, Steinbach JP, Harter PN, Ronellenfitsch MW. Cancers (Basel). 2020 Oct 20;12(10):3050. doi: 10.3390/cancers12103050. PubMed |
| Drp1 Tubulates the ER in a GTPase-Independent Manner. Adachi Y, Kato T, Yamada T, Murata D, Arai K, Stahelin RV, Chan DC, Iijima M, Sesaki H. Mol Cell. 2020 Nov 19;80(4):621-632.e6. doi: 10.1016/j.molcel.2020.10.013. Epub 2020 Nov 4. PubMed |
| RACK1 Mediates NLRP3 Inflammasome Activation by Promoting NLRP3 Active Conformation and Inflammasome Assembly. Duan Y, Zhang L, Angosto-Bazarra D, Pelegrin P, Nunez G, He Y. Cell Rep. 2020 Nov 17;33(7):108405. doi: 10.1016/j.celrep.2020.108405. PubMed |
| SARS-CoV-2 RNA reverse-transcribed and integrated into the human genome. Zhang L, Richards A, Khalil A, Wogram E, Ma H, Young RA, Jaenisch R. bioRxiv. 2020 Dec 13. doi: 10.1101/2020.12.12.422516. PubMed |
| Non-canonical Glutamate-Cysteine Ligase Activity Protects against Ferroptosis. Kang YP, Mockabee-Macias A, Jiang C, Falzone A, Prieto-Farigua N, Stone E, Harris IS, DeNicola GM. Cell Metab. 2021 Jan 5;33(1):174-189.e7. doi: 10.1016/j.cmet.2020.12.007. Epub 2020 Dec 22. PubMed |
| Quantitative Imaging of MS2-Tagged hTR in Cajal Bodies: Photobleaching and Photoactivation. Smith M, Querido E, Chartrand P, Sfeir A. STAR Protoc. 2020 Sep 24;1(3):100112. doi: 10.1016/j.xpro.2020.100112. eCollection 2020 Dec 18. PubMed |
| Targeting sphingosine kinase 1 (SK1) enhances oncogene-induced senescence through ceramide synthase 2 (CerS2)-mediated generation of very-long-chain ceramides. Trayssac M, Clarke CJ, Stith JL, Snider JM, Newen N, Gault CR, Hannun YA, Obeid LM. Cell Death Dis. 2021 Jan 4;12(1):27. doi: 10.1038/s41419-020-03281-4. PubMed |
A functional taxonomy of tumor suppression in oncogenic KRAS-driven lung cancer.
Cai H, Chew SK, Li C, Tsai MK, Andrejka L, Murray CW, Hughes NW, Shuldiner EG, Ashkin EL, Tang R, Hung KL, Chen LC, Lee SYC, Yousefi M, Lin WY, Kunder CA, Cong L, McFarland CD, Petrov DA, Swanton C, Winslow MM.
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| Targeting EphA2 suppresses hepatocellular carcinoma initiation and progression by dual inhibition of JAK1/STAT3 and AKT signaling. Wang H, Hou W, Perera A, Bettler C, Beach JR, Ding X, Li J, Denning MF, Dhanarajan A, Cotler SJ, Joyce C, Yin J, Ahmed F, Roberts LR, Qiu W. Cell Rep. 2021 Feb 23;34(8):108765. doi: 10.1016/j.celrep.2021.108765. PubMed |
| Generation and Breeding of EGFP-Transgenic Marmoset Monkeys: Cell Chimerism and Implications for Disease Modeling. Drummer C, Vogt EJ, Heistermann M, Roshani B, Becker T, Matz-Rensing K, Kues WA, Kugler S, Behr R. Cells. 2021 Feb 27;10(3). pii: cells10030505. doi: 10.3390/cells10030505. PubMed |
| RAF-Mutant Melanomas Differentially Depend on ERK2 Over ERK1 to Support Aberrant MAPK Pathway Activation and Cell Proliferation. Crowe MS, Zavorotinskaya T, Voliva CF, Shirley MD, Wang Y, Ruddy DA, Rakiec DP, Engelman JA, Stuart DD, Freeman AK. Mol Cancer Res. 2021 Jun;19(6):1063-1075. doi: 10.1158/1541-7786.MCR-20-1022. Epub 2021 Mar 11. PubMed |
| O-GlcNAcylation homeostasis controlled by calcium influx channels regulates multiple myeloma dissemination. Samart P, Luanpitpong S, Rojanasakul Y, Issaragrisil S. J Exp Clin Cancer Res. 2021 Mar 16;40(1):100. doi: 10.1186/s13046-021-01876-z. PubMed |
| In vivo CRISPR screening for novel noncoding RNA functional targets in glioblastoma models. Attenello FJ, Tsung K, Bishara I, Loh YE, Chen TC. J Neurosci Res. 2021 Sep;99(9):2029-2045. doi: 10.1002/jnr.24850. Epub 2021 May 10. PubMed |
| Unrestrained poly-ADP-ribosylation provides insights into chromatin regulation and human disease. Prokhorova E, Agnew T, Wondisford AR, Tellier M, Kaminski N, Beijer D, Holder J, Groslambert J, Suskiewicz MJ, Zhu K, Reber JM, Krassnig SC, Palazzo L, Murphy S, Nielsen ML, Mangerich A, Ahel D, Baets J, O'Sullivan RJ, Ahel I. Mol Cell. 2021 Jun 17;81(12):2640-2655.e8. doi: 10.1016/j.molcel.2021.04.028. Epub 2021 May 20. PubMed |
Tight nanoscale clustering of Fcgamma receptors using DNA origami promotes phagocytosis.
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| Glycogen Synthase Kinase 3 Beta Regulates the Human Aryl Hydrocarbon Receptor Cellular Content and Activity. Yang Y, Chan WK. Int J Mol Sci. 2021 Jun 5;22(11). pii: ijms22116097. doi: 10.3390/ijms22116097. PubMed |
| Single-Cell Analyses Reveal Diverse Mechanisms of Resistance to EGFR Tyrosine Kinase Inhibitors in Lung Cancer. Kashima Y, Shibahara D, Suzuki A, Muto K, Kobayashi IS, Plotnick D, Udagawa H, Izumi H, Shibata Y, Tanaka K, Fujii M, Ohashi A, Seki M, Goto K, Tsuchihara K, Suzuki Y, Kobayashi SS. Cancer Res. 2021 Sep 15;81(18):4835-4848. doi: 10.1158/0008-5472.CAN-20-2811. Epub 2021 Jul 9. PubMed |
| Mitofusin-2 regulates leukocyte adhesion and beta2 integrin activation. Liu W, Hsu AY, Wang Y, Lin T, Sun H, Pachter JS, Groisman A, Imperioli M, Yungher FW, Hu L, Wang P, Deng Q, Fan Z. J Leukoc Biol. 2022 Apr;111(4):771-791. doi: 10.1002/JLB.1A0720-471R. Epub 2021 Sep 8. PubMed |
| NSD2 dimethylation at H3K36 promotes lung adenocarcinoma pathogenesis. Sengupta D, Zeng L, Li Y, Hausmann S, Ghosh D, Yuan G, Nguyen TN, Lyu R, Caporicci M, Morales Benitez A, Coles GL, Kharchenko V, Czaban I, Azhibek D, Fischle W, Jaremko M, Wistuba II, Sage J, Jaremko L, Li W, Mazur PK, Gozani O. Mol Cell. 2021 Nov 4;81(21):4481-4492.e9. doi: 10.1016/j.molcel.2021.08.034. Epub 2021 Sep 22. PubMed |
| A guide in lentiviral vector production for hard-to-transfect cells, using cardiac-derived c-kit expressing cells as a model system. Kalidasan V, Ng WH, Ishola OA, Ravichantar N, Tan JJ, Das KT. Sci Rep. 2021 Sep 28;11(1):19265. doi: 10.1038/s41598-021-98657-7. PubMed |
| Interpretation of cancer mutations using a multiscale map of protein systems. Zheng F, Kelly MR, Ramms DJ, Heintschel ML, Tao K, Tutuncuoglu B, Lee JJ, Ono K, Foussard H, Chen M, Herrington KA, Silva E, Liu SN, Chen J, Churas C, Wilson N, Kratz A, Pillich RT, Patel DN, Park J, Kuenzi B, Yu MK, Licon K, Pratt D, Kreisberg JF, Kim M, Swaney DL, Nan X, Fraley SI, Gutkind JS, Krogan NJ, Ideker T. Science. 2021 Oct;374(6563):eabf3067. doi: 10.1126/science.abf3067. Epub 2021 Oct 1. PubMed |
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Beta RBD boost broadens antibody-mediated protection against SARS-CoV-2 variants in animal models.
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| Gene editing with CRISPR-Cas12a guides possessing ribose-modified pseudoknot handles. Ageely EA, Chilamkurthy R, Jana S, Abdullahu L, O'Reilly D, Jensik PJ, Damha MJ, Gagnon KT. Nat Commun. 2021 Nov 15;12(1):6591. doi: 10.1038/s41467-021-26989-z. PubMed |
| Ciliary Type III Adenylyl Cyclase in the VMH Is Crucial for High-Fat Diet-Induced Obesity Mediated by Autophagy. Yang D, Wu X, Wang W, Zhou Y, Wang Z. Adv Sci (Weinh). 2022 Jan;9(3):e2102568. doi: 10.1002/advs.202102568. Epub 2021 Nov 16. PubMed |
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| A beta-Catenin-TCF-Sensitive Locus Control Region Mediates GUCY2C Ligand Loss in Colorectal Cancer. Rappaport JA, Entezari AA, Caspi A, Caksa S, Jhaveri AV, Stanek TJ, Ertel A, Kupper J, Fortina PM, McMahon SB, Jaynes JB, Snook AE, Waldman SA. Cell Mol Gastroenterol Hepatol. 2022;13(4):1276-1296. doi: 10.1016/j.jcmgh.2021.12.014. Epub 2021 Dec 22. PubMed |
| SUMOylation inhibition enhances dexamethasone sensitivity in multiple myeloma. Du L, Liu W, Aldana-Masangkay G, Pozhitkov A, Pichiorri F, Chen Y, Rosen ST. J Exp Clin Cancer Res. 2022 Jan 4;41(1):8. doi: 10.1186/s13046-021-02226-9. PubMed |
| Restriction of extracellular lipids renders pancreatic cancer dependent on autophagy. Saliakoura M, Sebastiano MR, Nikdima I, Pozzato C, Konstantinidou G. J Exp Clin Cancer Res. 2022 Jan 8;41(1):16. doi: 10.1186/s13046-021-02231-y. PubMed |
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| A bispecific monomeric nanobody induces spike trimer dimers and neutralizes SARS-CoV-2 in vivo. Hanke L, Das H, Sheward DJ, Perez Vidakovics L, Urgard E, Moliner-Morro A, Kim C, Karl V, Pankow A, Smith NL, Porebski B, Fernandez-Capetillo O, Sezgin E, Pedersen GK, Coquet JM, Hallberg BM, Murrell B, McInerney GM. Nat Commun. 2022 Jan 10;13(1):155. doi: 10.1038/s41467-021-27610-z. PubMed |
| Distinctive Roles of YAP and TAZ in Human Endothelial Progenitor Cells Growth and Functions. Klaihmon P, Lorthongpanich C, Kheolamai P, Luanpitpong S, Issaragrisil S. Biomedicines. 2022 Jan 11;10(1):147. doi: 10.3390/biomedicines10010147. PubMed |
| De novo expression of gastrokines in pancreatic precursor lesions impede the development of pancreatic cancer. Steiner S, Seleznik GM, Reding T, Stopic M, Lenggenhager D, Ten Buren E, Eshmuminov D, Endhardt K, Hagedorn C, Heidenblut AM, Bratus-Neuenschwander A, Grossmann J, Trachsel C, Jabbar KS, Hahn SA, Berg JV, Graf R, Gupta A. Oncogene. 2022 Mar;41(10):1507-1517. doi: 10.1038/s41388-022-02182-4. Epub 2022 Jan 26. PubMed |
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LKB1 drives stasis and C/EBP-mediated reprogramming to an alveolar type II fate in lung cancer.
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| TRIM24 promotes colorectal cancer cell progression via the Wnt/beta-catenin signaling pathway activation. Tian H, Zhao H, Qu B, Chu X, Xin X, Zhang Q, Li W, Yang S. Am J Transl Res. 2022 Feb 15;14(2):831-848. eCollection 2022. PubMed |
| Muller glia fused with adult stem cells undergo neural differentiation in human retinal models. Bonilla-Pons SA, Nakagawa S, Bahima EG, Fernandez-Blanco A, Pesaresi M, D'Antin JC, Sebastian-Perez R, Greco D, Dominguez-Sala E, Gomez-Riera R, Compte RIB, Dierssen M, Pulido NM, Cosma MP. EBioMedicine. 2022 Mar;77:103914. doi: 10.1016/j.ebiom.2022.103914. Epub 2022 Mar 9. PubMed |
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Broadly neutralizing anti-S2 antibodies protect against all three human betacoronaviruses that cause deadly disease.
Zhou P, Song G, Liu H, Yuan M, He WT, Beutler N, Zhu X, Tse LV, Martinez DR, Schafer A, Anzanello F, Yong P, Peng L, Dueker K, Musharrafieh R, Callaghan S, Capozzola T, Limbo O, Parren M, Garcia E, Rawlings SA, Smith DM, Nemazee D, Jardine JG, Safonova Y, Briney B, Rogers TF, Wilson IA, Baric RS, Gralinski LE, Burton DR, Andrabi R.
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Neutralisation sensitivity of the SARS-CoV-2 omicron (B.1.1.529) variant: a cross-sectional study.
Sheward DJ, Kim C, Ehling RA, Pankow A, Castro Dopico X, Dyrdak R, Martin DP, Reddy ST, Dillner J, Karlsson Hedestam GB, Albert J, Murrell B.
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| VIVA1: a more invasive subclone of MDA-MB-134VI invasive lobular carcinoma cells with increased metastatic potential in xenograft models. Allen V, Coulombe J, Zhao H, Kreps LM, Cook DP, Pryce B, Clemons M, Vanderhyden BC, Gray DA, Addison CL. Br J Cancer. 2022 Jul;127(1):56-68. doi: 10.1038/s41416-022-01778-7. Epub 2022 Mar 22. PubMed |
Multivariate mining of an alpaca immune repertoire identifies potent cross-neutralizing SARS-CoV-2 nanobodies.
Hanke L, Sheward DJ, Pankow A, Vidakovics LP, Karl V, Kim C, Urgard E, Smith NL, Astorga-Wells J, Ekstrom S, Coquet JM, McInerney GM, Murrell B.
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| A Novel Sushi-IL15-PD1 CAR-NK92 Cell Line With Enhanced and PD-L1 Targeted Cytotoxicity Against Pancreatic Cancer Cells. Xu DL, He YQ, Xiao B, Si Y, Shi J, Liu XA, Tian L, Ren Q, Wu YS, Zhu Y. Front Oncol. 2022 Mar 22;12:726985. doi: 10.3389/fonc.2022.726985. eCollection 2022. PubMed |
| When killers become thieves: Trogocytosed PD-1 inhibits NK cells in cancer. Hasim MS, Marotel M, Hodgins JJ, Vulpis E, Makinson OJ, Asif S, Shih HY, Scheer AK, MacMillan O, Alonso FG, Burke KP, Cook DP, Li R, Petrucci MT, Santoni A, Fallon PG, Sharpe AH, Sciume G, Veillette A, Zingoni A, Gray DA, McCurdy A, Ardolino M. Sci Adv. 2022 Apr 15;8(15):eabj3286. doi: 10.1126/sciadv.abj3286. Epub 2022 Apr 13. PubMed |
| A Whole-Genome CRISPR Screen Identifies AHR Loss as a Mechanism of Resistance to a PARP7 Inhibitor. Chen H, Diolaiti ME, O'Leary PC, Rojc A, Krogan NJ, Kim M, Ashworth A. Mol Cancer Ther. 2022 Jul 5;21(7):1076-1089. doi: 10.1158/1535-7163.MCT-21-0841. PubMed |
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The nuclear receptor THRB facilitates differentiation of human PSCs into more mature hepatocytes.
Ma H, de Zwaan E, Guo YE, Cejas P, Thiru P, van de Bunt M, Jeppesen JF, Syamala S, Dall'Agnese A, Abraham BJ, Fu D, Garrett-Engele C, Lee TI, Long HW, Griffith LG, Young RA, Jaenisch R.
Cell Stem Cell. 2022 Apr 13. pii: S1934-5909(22)00150-3. doi: 10.1016/j.stem.2022.03.015.
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| GEM-IL: A highly responsive fluorescent lactate indicator. Bekdash R, Quejada JR, Ueno S, Kawano F, Morikawa K, Klein AD, Matsumoto K, Lee TC, Nakanishi K, Chalan A, Lee TM, Liu R, Homma S, Lin CS, Yelshanskaya MV, Sobolevsky AI, Goda K, Yazawa M. Cell Rep Methods. 2021 Oct 21;1(7):100092. doi: 10.1016/j.crmeth.2021.100092. eCollection 2021 Nov 22. PubMed |
| Loss of PRMT7 reprograms glycine metabolism to selectively eradicate leukemia stem cells in CML. Liu C, Zou W, Nie D, Li S, Duan C, Zhou M, Lai P, Yang S, Ji S, Li Y, Mei M, Bao S, Jin Y, Pan J. Cell Metab. 2022 Jun 7;34(6):818-835.e7. doi: 10.1016/j.cmet.2022.04.004. Epub 2022 May 3. PubMed |
| A New Functional Screening Platform Identifies Colistin Sulfate as an Enhancer of Natural Killer Cell Cytotoxicity. Cortes-Kaplan S, Kurdieh R, Hasim MS, Kaczmarek S, Taha Z, Maznyi G, McComb S, Lee SH, Diallo JS, Ardolino M. Cancers (Basel). 2022 Jun 8;14(12). pii: cancers14122832. doi: 10.3390/cancers14122832. PubMed |
| Cryo-electron tomography of Birbeck granules reveals the molecular mechanism of langerin lattice formation. Oda T, Yanagisawa H, Shinmori H, Ogawa Y, Kawamura T. Elife. 2022 Jun 27;11. pii: 79990. doi: 10.7554/eLife.79990. PubMed |
| Dolutegravir Inhibits Proliferation and Motility of BT-20 Tumor Cells Through Inhibition of Human Endogenous Retrovirus Type K. Li J, Lin J, Lin JR, Farris M, Robbins L, Andrada L, Grohol B, Nong S, Liu Y. Cureus. 2022 Jul 3;14(7):e26525. doi: 10.7759/cureus.26525. eCollection 2022 Jul. PubMed |
| Chromatin-bound RB targets promoters, enhancers, and CTCF-bound loci and is redistributed by cell-cycle progression. Sanidas I, Lee H, Rumde PH, Boulay G, Morris R, Golczer G, Stanzione M, Hajizadeh S, Zhong J, Ryan MB, Corcoran RB, Drapkin BJ, Rivera MN, Dyson NJ, Lawrence MS. Mol Cell. 2022 Sep 15;82(18):3333-3349.e9. doi: 10.1016/j.molcel.2022.07.014. Epub 2022 Aug 17. PubMed |
| TRIM28 Is a Novel Regulator of CD133 Expression Associated with Cancer Stem Cell Phenotype. Kim YS, Potashnikova DM, Gisina AM, Kholodenko IV, Kopylov AT, Tikhonova OV, Kurbatov LK, Saidova AA, Tvorogova AV, Kholodenko RV, Belousov PV, Vorobjev IA, Zgoda VG, Yarygin KN, Lupatov AY. Int J Mol Sci. 2022 Aug 30;23(17):9874. doi: 10.3390/ijms23179874. PubMed |
| Inhibition of O-GlcNAcase Inhibits Hematopoietic and Leukemic Stem Cell Self-Renewal and Drives Dendritic Cell Differentiation via STAT3/5 Signaling. Luanpitpong S, Rodboon N, Samart P, Janan M, Klaihmon P, Lorthongpanich C, U-Pratya Y, Issaragrisil S. Stem Cells. 2022 Dec 31;40(12):1078-1093. doi: 10.1093/stmcls/sxac068. PubMed |
| Cell clusters adopt a collective amoeboid mode of migration in confined nonadhesive environments. Pages DL, Dornier E, de Seze J, Gontran E, Maitra A, Maciejewski A, Wang L, Luan R, Cartry J, Canet-Jourdan C, Raingeaud J, Lemahieu G, Lebel M, Ducreux M, Gelli M, Scoazec JY, Coppey M, Voituriez R, Piel M, Jaulin F. Sci Adv. 2022 Sep 30;8(39):eabp8416. doi: 10.1126/sciadv.abp8416. Epub 2022 Sep 30. PubMed |
| Multiple centrosomes enhance migration and immune cell effector functions of mature dendritic cells. Weier AK, Homrich M, Ebbinghaus S, Juda P, Mikova E, Hauschild R, Zhang L, Quast T, Mass E, Schlitzer A, Kolanus W, Burgdorf S, Gruss OJ, Hons M, Wieser S, Kiermaier E. J Cell Biol. 2022 Dec 5;221(12):e202107134. doi: 10.1083/jcb.202107134. Epub 2022 Oct 10. PubMed |
| NSP4 and ORF9b of SARS-CoV-2 Induce Pro-Inflammatory Mitochondrial DNA Release in Inner Membrane-Derived Vesicles. Faizan MI, Chaudhuri R, Sagar S, Albogami S, Chaudhary N, Azmi I, Akhtar A, Ali SM, Kumar R, Iqbal J, Joshi MC, Kharya G, Seth P, Roy SS, Ahmad T. Cells. 2022 Sep 23;11(19):2969. doi: 10.3390/cells11192969. PubMed |
| Tumor-intrinsic SIRPA promotes sensitivity to checkpoint inhibition immunotherapy in melanoma. Zhou Z, Chen MM, Luo Y, Mojumdar K, Peng X, Chen H, Kumar SV, Akbani R, Lu Y, Liang H. Cancer Cell. 2022 Nov 14;40(11):1324-1340.e8. doi: 10.1016/j.ccell.2022.10.012. Epub 2022 Nov 3. PubMed |
Rare, convergent antibodies targeting the stem helix broadly neutralize diverse betacoronaviruses.
Dacon C, Peng L, Lin TH, Tucker C, Lee CD, Cong Y, Wang L, Purser L, Cooper AJR, Williams JK, Pyo CW, Yuan M, Kosik I, Hu Z, Zhao M, Mohan D, Peterson M, Skinner J, Dixit S, Kollins E, Huzella L, Perry D, Byrum R, Lembirik S, Murphy M, Zhang Y, Yang ES, Chen M, Leung K, Weinberg RS, Pegu A, Geraghty DE, Davidson E, Doranz BJ, Douagi I, Moir S, Yewdell JW, Schmaljohn C, Crompton PD, Mascola JR, Holbrook MR, Nemazee D, Wilson IA, Tan J.
Cell Host Microbe. 2022 Nov 4. pii: S1931-3128(22)00523-6. doi: 10.1016/j.chom.2022.10.010.
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| An mTORC1 to HRI signaling axis promotes cytotoxicity of proteasome inhibitors in multiple myeloma. Darawshi O, Muz B, Naamat SG, Praveen B, Mahameed M, Goldberg K, Dipta P, Shmuel M, Forno F, Boukeileh S, Pahima H, Hermann J, Raab MS, Poos AM, Weinhold N, Rosenbluh C, Gatt ME, Palm W, Azab AK, Tirosh B. Cell Death Dis. 2022 Nov 18;13(11):969. doi: 10.1038/s41419-022-05421-4. PubMed |
| The leucine-rich repeat (LRR) domain of NLRP3 is required for NLRP3 inflammasome activation in macrophages. Duan Y, Wang J, Cai J, Kelley N, He Y. J Biol Chem. 2022 Dec;298(12):102717. doi: 10.1016/j.jbc.2022.102717. Epub 2022 Nov 17. PubMed |
| Combating Drug Resistance by Exploiting miRNA-200c-Controlled Phase II Detoxification. Kohler B, Dubovik S, Horterer E, Wilk U, Stockl JB, Tekarslan-Sahin H, Ljepoja B, Paulitschke P, Frohlich T, Wagner E, Roidl A. Cancers (Basel). 2022 Nov 11;14(22):5554. doi: 10.3390/cancers14225554. PubMed |
| Bcl-2 Family Members Bcl-xL and Bax Cooperatively Contribute to Bortezomib Resistance in Mantle Cell Lymphoma. Luanpitpong S, Janan M, Yosudjai J, Poohadsuan J, Chanvorachote P, Issaragrisil S. Int J Mol Sci. 2022 Nov 21;23(22):14474. doi: 10.3390/ijms232214474. PubMed |
| CEACAM1 is a direct SOX10 target and inhibits melanoma immune infiltration and stemness. Abou-Hamad J, Hodgins JJ, de Souza CT, Garland B, Labreche C, Marotel M, Gibson C, Delisle S, Pascoal J, Auer RC, Ardolino M, Sabourin LA. iScience. 2022 Nov 7;25(12):105524. doi: 10.1016/j.isci.2022.105524. eCollection 2022 Dec 22. PubMed |
| The Sall2 transcription factor promotes cell migration regulating focal adhesion turnover and integrin beta1 expression. Riffo E, Palma M, Hepp MI, Benitez-Riquelme D, Torres VA, Castro AF, Pincheira R. Front Cell Dev Biol. 2022 Nov 9;10:1031262. doi: 10.3389/fcell.2022.1031262. eCollection 2022. PubMed |
| Heterogeneous nuclear ribonucleoprotein K is overexpressed in acute myeloid leukemia and causes myeloproliferation in mice via altered Runx1 splicing. Aitken MJL, Malaney P, Zhang X, Herbrich SM, Chan L, Benitez O, Rodriguez AG, Ma H, Jacamo R, Duan R, Link TM, Kornblau SM, Kanagal-Shamanna R, Bueso-Ramos CE, Post SM. NAR Cancer. 2022 Dec 9;4(4):zcac039. doi: 10.1093/narcan/zcac039. eCollection 2022 Dec. PubMed |
| Immunoglobulin germline gene polymorphisms influence the function of SARS-CoV-2 neutralizing antibodies. Pushparaj P, Nicoletto A, Sheward DJ, Das H, Castro Dopico X, Perez Vidakovics L, Hanke L, Chernyshev M, Narang S, Kim S, Fischbach J, Ekstrom S, McInerney G, Hallberg BM, Murrell B, Corcoran M, Karlsson Hedestam GB. Immunity. 2023 Jan 10;56(1):193-206.e7. doi: 10.1016/j.immuni.2022.12.005. Epub 2022 Dec 12. PubMed |
| Gene regulatory network reconfiguration in direct lineage reprogramming. Kamimoto K, Adil MT, Jindal K, Hoffmann CM, Kong W, Yang X, Morris SA. Stem Cell Reports. 2023 Jan 10;18(1):97-112. doi: 10.1016/j.stemcr.2022.11.010. Epub 2022 Dec 29. PubMed |
| Upregulation of PD-L1 by SARS-CoV-2 promotes immune evasion. Huang HC, Wang SH, Fang GC, Chou WC, Liao CC, Sun CP, Jan JT, Ma HH, Ko HY, Ko YA, Chiang MT, Liang JJ, Kuo CT, Lee TA, Morales-Scheihing D, Shen CY, Chen SY, McCullough LD, Cui L, Wernig G, Tao MH, Lin YL, Chang YM, Wang SP, Lai YJ, Li CW. J Med Virol. 2023 Feb;95(2):e28478. doi: 10.1002/jmv.28478. PubMed |
| T cell-derived interleukin-22 drives the expression of CD155 by cancer cells to suppress NK cell function and promote metastasis. Briukhovetska D, Suarez-Gosalvez J, Voigt C, Markota A, Giannou AD, Schubel M, Jobst J, Zhang T, Dorr J, Markl F, Majed L, Muller PJ, May P, Gottschlich A, Tokarew N, Lucke J, Oner A, Schwerdtfeger M, Andreu-Sanz D, Grunmeier R, Seifert M, Michaelides S, Hristov M, Konig LM, Cadilha BL, Mikhaylov O, Anders HJ, Rothenfusser S, Flavell RA, Cerezo-Wallis D, Tejedo C, Soengas MS, Bald T, Huber S, Endres S, Kobold S. Immunity. 2023 Jan 10;56(1):143-161.e11. doi: 10.1016/j.immuni.2022.12.010. PubMed |
| A hierarchical pathway for assembly of the distal appendages that organize primary cilia. Kanie T, Love JF, Fisher SD, Gustavsson AK, Jackson PK. bioRxiv [Preprint]. 2023 Jan 10:2023.01.06.522944. doi: 10.1101/2023.01.06.522944. PubMed |
| Myristoylated Neuronal Calcium Sensor-1 captures the ciliary vesicle at distal appendages. Kanie T, Ng R, Abbott KL, Pongs O, Jackson PK. bioRxiv. 2023 Jan 10:2023.01.06.523037. doi: 10.1101/2023.01.06.523037. Preprint. PubMed |
| Single-chromosome dynamics reveals locus-dependent dynamics and chromosome territory orientation. Chung YC, Bisht M, Thuma J, Tu LC. J Cell Sci. 2023 Feb 15;136(4):jcs260137. doi: 10.1242/jcs.260137. Epub 2023 Feb 27. PubMed |
| Combining single-cell transcriptomics and CellTagging to identify differentiation trajectories of human adipose-derived mesenchymal stem cells. Lin K, Yang Y, Cao Y, Liang J, Qian J, Wang X, Han Q. Stem Cell Res Ther. 2023 Feb 1;14(1):14. doi: 10.1186/s13287-023-03237-3. PubMed |
| NFATc1 marks articular cartilage progenitors and negatively determines articular chondrocyte differentiation. Zhang F, Wang Y, Zhao Y, Wang M, Zhou B, Zhou B, Ge X. Elife. 2023 Feb 15;12:e81569. doi: 10.7554/eLife.81569. PubMed |
| PARP1 associates with R-loops to promote their resolution and genome stability. Laspata N, Kaur P, Mersaoui SY, Muoio D, Liu ZS, Bannister MH, Nguyen HD, Curry C, Pascal JM, Poirier GG, Wang H, Masson JY, Fouquerel E. Nucleic Acids Res. 2023 Mar 21;51(5):2215-2237. doi: 10.1093/nar/gkad066. PubMed |
| Sorting nexin 10 sustains PDGF receptor signaling in glioblastoma stem cells via endosomal protein sorting. Gimple RC, Zhang G, Wang S, Huang T, Lee J, Taori S, Lv D, Dixit D, Halbert ME, Morton AR, Kidwell RL, Dong Z, Prager BC, Kim LJ, Qiu Z, Zhao L, Xie Q, Wu Q, Agnihotri S, Rich JN. JCI Insight. 2023 Mar 22;8(6):e158077. doi: 10.1172/jci.insight.158077. PubMed |
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An adenine base editor variant expands context compatibility.
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