6,471 results

1. AiP1894 - pAAV-AiE2582m-minBG-SYFP2-WPRE-BGHpA

   Plasmid

   #214573

   Purpose

   AiE2582m is an enhancer sequence, designed to drive AAV-mediated transgene expression in specific populations of brain cells

   Depositor

   Allen Institute for Brain Science, Bosiljka Tasic

   Article

   Ben-Simon et al Cell. 2025 May 16:S0092-8674(25)00513-6.

   Insert

   SYFP2
   

   Use

   AAV

   Promoter

   minBG

   Available Since

   June 24, 2024

   Availability

   Academic Institutions and Nonprofits only

   

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2. pAAV-hnEF Coff/Fon hChR2(H134R)-EYFP

   Plasmid

   #55649

   Purpose

   Cre-off/Flp-on ChR2-EYFP under the short Ef1a promoter

   Depositor

   Karl Deisseroth

   Article

   Fenno et al Nat Methods. 2014 Jul;11(7):763-72. doi:

   Insert

   ChR2(H134R)-EYFP
   

   Use

   AAV; Cre off/flp on chr2-eyfp

   Tags

   EYFP

   Expression

   Mammalian

   Promoter

   Short Ef1

   Available Since

   June 25, 2015

   Availability

   Academic Institutions and Nonprofits only

   

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3. pAAV-hsyn-flex-Voltron

   Plasmid

   #119035

   Purpose

   Cre-dependant expression of Voltron in neurons

   Depositor

   Eric Schreiter

   Article

   Abdelfattah et al Science. 2019 Aug 1. pii: science.aav641

   Insert

   Voltron
   

   Use

   AAV

   Expression

   Mammalian

   Promoter

   hsyn

   Available Since

   Dec. 19, 2018

   Availability

   Academic Institutions and Nonprofits only

   

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4. pAAV-CAG-iSeroSnFR-Nlgn

   Plasmid

   #128485

   Purpose

   Fluorescent reporter for serotonin (dendrite localization tag)

   Depositor

   Lin Tian

   Article

   Unger et al Cell. 2020 Dec 12. pii: S0092-8674(20)31

   Has Service

   AAV9

   Insert

   iSeroSnFR
   

   Use

   AAV

   Tags

   Full-length neuroligin, Ig-kappa leader, and cpsf…

   Expression

   Mammalian

   Promoter

   CAG

   Available Since

   Dec. 23, 2020

   Availability

   Academic Institutions and Nonprofits only

   

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5. pAAV-CaMKIIa-SwiChRca-TS-EYFP

   Plasmid

   #55630

   Purpose

   Chloride Channel

   Depositor

   Karl Deisseroth

   Article

   Berndt et al Science. 2014 Apr 25;344(6182):420-4. do

   Insert

   iC1C2-TS-EYFP
   

   Use

   AAV

   Tags

   EYFP

   Expression

   Mammalian

   Mutation

   C128A

   Promoter

   CaMKIIa

   Available Since

   July 22, 2014

   Availability

   Academic Institutions and Nonprofits only

   

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6. AiP13999 - pAAV-AiE0387m-minBG-iCre(R297T)-BGHpA (Alias: CN3999)

   Plasmid

   #208166

   Purpose

   AiE0387m is an enhancer sequence designed to drive AAV-mediated Cre recombination in brain astrocytes

   Depositor

   Allen Institute for Brain Science, Jonathan Ting

   Article

   Ben-Simon et al Cell. 2025 May 16:S0092-8674(25)00513-6.

   Insert

   iCreR297T
   

   Use

   AAV

   Mutation

   NA

   Promoter

   Beta Globin minimal promoter

   Available Since

   Oct. 23, 2023

   Availability

   Academic Institutions and Nonprofits only

   

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7. aav-tnt-gfp-v2

   Plasmid

   #165036

   Purpose

   AAV-based delivery of GFP into cardiomyocytes in vivo

   Depositor

   William Pu

   Article

   Guo et al Proc Natl Acad Sci U S A. 2021 Jan 12;11

   Type

   Empty backbone

   Use

   AAV

   Available Since

   March 8, 2021

   Availability

   Academic Institutions and Nonprofits only

   

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8. GfaABC1D-cyto-Ruby3-iATPSnFR1.0

   Plasmid

   #102554

   Purpose

   expresses cytoplasmic ATP sensor in astrocytes with red reference protein

   Depositor

   Baljit Khakh

   Article

   Lobas et al Nat Commun. 2019 Feb 12;10(1):711. doi:

   Insert

   mRuby3-iATPSnFR1.0
   

   Use

   AAV

   Available Since

   Jan. 10, 2019

   Availability

   Academic Institutions and Nonprofits only

   

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9. pAAV-CaMKII-Ace-mNeon2

   Plasmid

   #195526

   Purpose

   Green fluorescent, negative response-polarity voltage indicator under the control of CaMKII promoter

   Depositor

   Vincent Pieribone

   Article

   Kannan et al Science. 2022 Nov 4;378(6619):eabm8797.

   Insert

   Ace-mNeon2
   

   Use

   AAV

   Expression

   Mammalian

   Mutation

   Ace-mNeon 81S; SY linker

   Promoter

   CaMKII

   Available Since

   Jan. 30, 2023

   Availability

   Academic Institutions and Nonprofits only

   

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10. pSR651

    Plasmid

    #65213

    Purpose

    Baculovirus-mediated rAAV production: Expresses bicistronic AAV-2 rep gene and polycistronic AAV-1 cap gene in Sf9 insect cells

    Depositor

    Robert Kotin

    Article

    Smith et al Mol Ther. 2009 Nov;17(11):1888-96. doi:

    Inserts

    modified AAV-2 rep78
    modified AAV-1 cap
    

    Use

    AAV

    Expression

    Insect

    Promoter

    p10 and polyhedrin

    Available Since

    June 10, 2015

    Availability

    Academic Institutions and Nonprofits only

    

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11. pZac2.1 gfaABC1D-Ezr-eGFP

    Plasmid

    #176856

    Purpose

    Expresses Ezrin fused with eGFP at the C-terminus in astrocytes

    Depositor

    Baljit Khakh

    Article

    Soto et al Nature. 2023 Apr;616(7958):764-773. doi:

    Insert

    Ezr-GFP
    

    Use

    AAV

    Tags

    GFP

    Expression

    Bacterial

    Promoter

    gfaABC1D

    Available Since

    April 11, 2023

    Availability

    Academic Institutions and Nonprofits only

    

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12. pAAV-CaMP0.4-FHS-paCaMKII(SD)-WPRE3

    Plasmid

    #165430

    Purpose

    Expresses light-insensitive photoactivatable CaMKII(SD: Super Dark) in mammalian cells as a negative control.

    Depositor

    Hideji Murakoshi

    Article

    Shibata et al Nat Commun. 2021 Feb 2;12(1):751. doi: 1

    Insert

    FHS-paCaMKII(SD)
    

    Use

    AAV

    Tags

    FHS(Flag, HisX6, Strep) tag

    Expression

    Mammalian

    Mutation

    C450A, L514K, G528A, L531E, N538E: Light-insensit…

    Promoter

    CaMKII0.4

    Available Since

    March 2, 2021

    Availability

    Academic Institutions and Nonprofits only

    

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13. aav-hsp68-mCherry-MCS-pA

    Plasmid

    #195412

    Purpose

    AAV9 based MPRA assay

    Depositor

    William Pu

    Article

    Akerberg et al Nat Commun. 2019 Oct 28;10(1):4907. doi:

    Type

    Empty backbone

    Use

    AAV

    Available Since

    Feb. 14, 2023

    Availability

    Academic Institutions and Nonprofits only

    

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14. pAAV-nef-CIAO-Flp

    Plasmid

    #149294

    Purpose

    Cre-dependent expression of Flp recombinase.

    Depositor

    Edward Callaway

    Article

    Fischer et al Proc Natl Acad Sci U S A. 2019 Dec 16. p

    Insert

    Flp recombinase (flp Budding Yeast)
    

    Use

    AAV

    Mutation

    Derived from the mouse codon-optomized FlpO. The…

    Available Since

    Aug. 4, 2020

    Availability

    Academic Institutions and Nonprofits only

    

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15. pAAV-TIWB-yellow pre-eGRASP(p32)

    Plasmid

    #111582

    Purpose

    An AAV vector that expresses yellow pre-eGRASP(p32) under the tetO promoter.

    Depositor

    Bong-Kiun Kaang

    Article

    Choi et al Science. 2018 Apr 27;360(6387):430-435.

    Insert

    yellow pre-eGRASP(p32)
    

    Use

    AAV

    Promoter

    tetO

    Available Since

    June 12, 2018

    Availability

    Academic Institutions and Nonprofits only

    

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16. pAAV-nEF-Con/Foff DREADD Gi-mCherry

    Plasmid

    #177673

    Purpose

    Expresses DREADD hM4D (Gi) only in Cre expressing cells and not in Flp expressing cells

    Depositor

    Karl Deisseroth

    Has Service

    AAV8

    Insert

    DREADD Gi-mCherry
    

    Use

    AAV, Cre/Lox, and Mouse Targeting ; Intrsect

    Tags

    mCherry

    Expression

    Mammalian

    Promoter

    nEF

    Available Since

    Nov. 23, 2021

    Availability

    Academic Institutions and Nonprofits only

    

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17. hSyn-GtACR2-ChRmine-tandem-eYFP

    Plasmid

    #192580

    Purpose

    AAV-vector for bidirectional optogenetic manipulation of neurons

    Depositor

    Simon Wiegert

    Article

    Vierock et al Nat Commun. 2021 Jul 26;12(1):4527. doi:

    Insert

    somBiPOLES
    

    Use

    AAV

    Tags

    EYFP- soma-targeting motif from Kv2.1 channel

    Expression

    Mammalian

    Promoter

    human synapsin

    Available Since

    April 3, 2023

    Availability

    Academic Institutions and Nonprofits only

    

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18. pAAV-ProA1-GCaMP6s

    Plasmid

    #126002

    Purpose

    Targeting expression to neuronal and glial cell types in mice, non-human primates, and human retina

    Depositor

    Botond Roska

    Article

    Juttner et al Nat Neurosci. 2019 Jul 8. pii: 10.1038/s

    Insert

    GCaMP6s
    

    Use

    AAV

    Promoter

    ProA1

    Available Since

    Oct. 31, 2019

    Availability

    Academic Institutions and Nonprofits only

    

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19. pAAV-iCre-2A-cherry

    Plasmid

    #182246

    Purpose

    Expresses iCre linked to mCherry. The promoter is a fragment of the hdc gene promoter which drives pan neuronal expression.

    Depositor

    William Wisden

    Article

    Miracca et al J Neurosci. 2022 May 31. pii: JNEUROSCI.

    Insert

    pan neuronal gene promoter (hdc) fragment driving iCre recombinase and 2A linked to mCherry
    

    Use

    AAV and Cre/Lox

    Expression

    Mammalian

    Promoter

    fragment of histidine decarboxylase gene promoter…

    Available Since

    March 4, 2022

    Availability

    Academic Institutions and Nonprofits only

    

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20. pAAV.U6gLacZ.hSyn.flex.H2B.RFP

    Plasmid

    #170373

    Purpose

    Negative control guide, Cre-inducible plasmid expressing nuclear RFP.

    Depositor

    Johan Jakobsson

    Article

    Jonsson et al EMBO J. 2021 Mar 1:e106423. doi: 10.1525

    Insert

    Cre inducible H2B RFP
    

    Use

    AAV

    Promoter

    human Synapsin

    Available Since

    Jan. 4, 2022

    Availability

    Academic Institutions and Nonprofits only

    

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21. U6-pegRNA-H1-nick sgRNA-mCherry

    Plasmid

    #176901

    Purpose

    Expresses prime editing guide RNA and guide RNA in mammalian cells

    Depositor

    Hyongbum Kim

    Article

    Jang et al Nat Biomed Eng. 2021 Aug 26. pii: 10.103

    Inserts

    mCherry
    gRNA scaffold
    gRNA scaffold
    

    Use

    AAV

    Expression

    Mammalian

    Promoter

    CAG, H1, and U6

    Available Since

    Dec. 13, 2021

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

22. AAV.hSyn.GLPLight-ctr

    Plasmid

    #187468

    Purpose

    Expresses GLPLight-ctr in mammalian cells

    Depositor

    Tommaso Patriarchi

    Article

    Duffet et al Elife. 2023 Jun 2;12:RP86628. doi: 10.75

    Insert

    GLPLight-ctr
    

    Use

    AAV

    Tags

    Flag tag

    Promoter

    human Synapsin-1

    Available Since

    Feb. 16, 2023

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

23. pAAV.hSynapsin1.OxLight-ctr

    Plasmid

    #169793

    Purpose

    Control non-binding fluorescent reporter for orexin neuropeptides

    Depositor

    Tommaso Patriarchi

    Article

    Duffet et al Nat Methods. 2022 Feb;19(2):231-241. doi

    Insert

    OxLight-ctr
    

    Use

    AAV

    Mutation

    E54K; T111A

    Promoter

    human Synapsin-1

    Available Since

    Feb. 11, 2022

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

24. pAAV-CaMKIIa-HA-hM4D(Gi)-IRES-mCitrine

    Plasmid

    #50467

    Purpose

    Gi-coupled hM4D-IRES-mCitrine under the control of CaMKIIa promoter

    Depositor

    Bryan Roth

    Has Service

    AAV2 and AAV8

    Insert

    hM4D(Gi)-IRES-mCitrine (CHRM4 Human)
    

    Use

    AAV

    Tags

    HA

    Mutation

    See supplemental documents for DREADD mutations

    Promoter

    CaMKIIa

    Available Since

    April 16, 2014

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

25. (564) pAAV Alb-AAT KRAB-SadCas9 U6-mPcsk9

    Plasmid

    #163025

    Purpose

    Expression of CRISPRi with gRNA against mouse Pcsk9

    Depositor

    Tonia Rex

    Article

    Backstrom et al Mol Ther Methods Clin Dev. 2020 Sep 6;19

    Insert

    Mammalian codon-optimized SadCas9 (Pcsk9 S. aureus)
    

    Use

    AAV

    Tags

    KRAB, SV40 pA, and myc NLS

    Expression

    Mammalian

    Promoter

    Alb-AAT

    Available Since

    Jan. 8, 2021

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

26. 1255_pAAV-U6-SA-BbsI-MluI-gRNA-CB-SACas9-HA-OLLAS-spA

    Plasmid

    #109320

    Purpose

    Plasmid for AAV SaCas9 Mammalian Expression with a BbsI cloning site for a gRNA

    Depositor

    William Lagor

    Article

    Jarrett et al Arterioscler Thromb Vasc Biol. 2018 Jul

    Type

    Empty backbone

    Use

    AAV and CRISPR

    Expression

    Mammalian

    Available Since

    June 28, 2018

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

27. pAAV-hsyn-flex-Positron-ST

    Plasmid

    #129267

    Purpose

    Cre-dependant expression of soma-localized Positron in neurons

    Depositor

    Eric Schreiter

    Article

    Abdelfattah et al Nat Commun. 2020 Jul 10;11(1):3444. doi:

    Insert

    Positron-ST
    

    Use

    AAV

    Expression

    Mammalian

    Mutation

    D92N, E199V

    Promoter

    hsyn

    Available Since

    Oct. 18, 2019

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

28. pAAV-GFAP-HA-hM4D(Gi)-IRES-mCitrine

    Plasmid

    #50471

    Purpose

    Gi-coupled hM4D-IRES-mCitrine under the control of GFAP promoter

    Depositor

    Bryan Roth

    Insert

    hM4D(Gi)-IRES-mCitrine (CHRM4 Human)
    

    Use

    AAV

    Tags

    HA

    Mutation

    See supplemental documents for DREADD mutations

    Promoter

    GFAP

    Available Since

    April 16, 2014

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

29. pAAV-Syn-FLEX-rc[Chronos-GFP]

    Plasmid

    #62722

    Purpose

    AAV-mediated expression of Chronos-GFP under the Syn promoter, in floxed/reversed (Cre-dependent) manner. Using bGHpA signal.

    Depositor

    Edward Boyden

    Article

    Klapoetke et al Nat Methods. 2014 Mar;11(3):338-46. doi:

    Insert

    Chronos-GFP
    

    Use

    AAV

    Tags

    GFP

    Expression

    Mammalian

    Promoter

    human synapsin promoter

    Available Since

    April 30, 2015

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

30. pAAV-CAG-EGFP barcode-0-SV40 polyA

    Plasmid

    #190864

    Purpose

    For barcoded retrograde labeling

    Depositor

    Yuejun Chen

    Article

    Xu et al Elife. 2024 Feb 23;13:e85419. doi: 10.75

    Insert

    EGFP-barcode0
    

    Use

    AAV

    Mutation

    WT

    Available Since

    Nov. 14, 2022

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

31. rAAV-syn::FLEX-rev::PSAML141F,Y115F:GlyR-IRES-GFP

    Plasmid

    #32481

    Purpose

    Cre-dependent expression of PSAM-GlyR (L141F,Y115F) neuronal inhibitor, with IRES-EGFP marker

    Depositor

    Scott Sternson

    Article

    Magnus et al Science. 2011 Sep 2;333(6047):1292-6.

    Insert

    PSAML141F,Y115F-GlyR
    

    Use

    AAV and Cre/Lox; Adeno-associated virus, flex swi…

    Tags

    IRES-EGFP

    Promoter

    Synapsin

    Available Since

    Jan. 13, 2012

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

32. pAAV-TRE-vDIO-mScarlet-IRES-tTA

    Plasmid

    #118030

    Purpose

    AAV vector for sparse and bright labeling in a cell-type specific manner

    Depositor

    Minmin Luo

    Article

    Lin et al Nat Methods. 2018 Nov 19. pii: 10.1038/s

    Insert

    TRE-vDIO-mScarlet-IRES-tTA
    

    Use

    AAV

    Promoter

    TRE

    Available Since

    Nov. 30, 2018

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

33. pAAV-EF1α-FRT-FLEX-GtACR1-EYFP

    Plasmid

    #114370

    Purpose

    expresses Flpo recombinase-dependent GtACR1

    Depositor

    Mingshan Xue

    Article

    Messier et al Elife. 2018 Aug 9;7. pii: 38506. doi: 10

    Insert

    GtACR1-EYFP (NEWENTRY )
    

    Use

    AAV

    Tags

    EYFP

    Expression

    Mammalian

    Promoter

    Ef1a

    Available Since

    Aug. 24, 2018

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

34. AiP12653 - pAAV-AiE0720h-minBG-SYFP2-WPRE3-BGHpA (Alias: CN2653)

    Plasmid

    #224001

    Purpose

    AiE0720h is an enhancer sequence, designed to drive AAV-mediated transgene expression in cortical L4/5_IT neurons

    Depositor

    Allen Institute for Brain Science, Jonathan Ting

    Article

    Ben-Simon et al Cell. 2025 May 16:S0092-8674(25)00513-6.

    Insert

    SYFP2
    

    Use

    AAV

    Mutation

    NA

    Promoter

    minBG

    Available Since

    Oct. 21, 2024

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

35. AAV-TRE-NS1NF

    Plasmid

    #175279

    Purpose

    AAV vector mediating inducible expression of the NS1 gene of YFV-17D

    Depositor

    Wei Xu

    Article

    Li et al Nat Methods. 2021 Nov 25. pii: 10.1038/s

    Insert

    NS1 (POLY Yellow fever virus strain 17D)
    

    Use

    AAV

    Promoter

    tight TRE

    Available Since

    Dec. 8, 2021

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

36. pGFAP-TetOn3G

    Plasmid

    #133728

    Purpose

    Plasmid contains the TetOn3G-transactivator sequence under control of a GFAP promoter.

    Depositor

    Erin Schuman

    Article

    Heumuller et al Nat Methods. 2019 Jul 15. pii: 10.1038/s

    Insert

    TetOn3G
    

    Use

    AAV

    Expression

    Mammalian

    Promoter

    pGFAP

    Available Since

    Dec. 18, 2019

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

37. AAV-mDlx-jGCaMP8s-WPRE

    Plasmid

    #176755

    Purpose

    jGCaMP8s expression in GABA-ergic interneurons under the control of mDlx enhancer

    Depositor

    Loren Looger

    Has Service

    AAV Retrograde, AAV1, and AAV9

    Insert

    jGCaMP8s
    

    Use

    AAV

    Tags

    6xHis

    Expression

    Mammalian

    Promoter

    mDlx

    Available Since

    Nov. 30, 2021

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

38. pAAV-G88P7-rM3Ds-2A-EYFP

    Plasmid

    #213970

    Purpose

    AAV vector with G88P7 promoter in order to induce robust expression of rM3Ds in MSNs

    Depositor

    Zhonghua Lu

    Article

    Chen et al Cell. 2023 Nov 22;186(24):5394-5410.e18.

    Insert

    rM3Ds
    

    Use

    AAV

    Promoter

    G88P7

    Available Since

    April 29, 2024

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

39. pAAV-FLEX-NBL10

    Plasmid

    #69971

    Purpose

    Cre-conditionally expresses the anti-GFP Nanobody-Rpl10a fusion

    Depositor

    Jeffrey Friedman

    Article

    Ekstrand et al Cell. 2014 May 22;157(5):1230-42. doi: 1

    Insert

    NBL10
    

    Use

    AAV and Cre/Lox

    Tags

    HA

    Expression

    Mammalian

    Promoter

    EF1a

    Available Since

    Oct. 19, 2015

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

40. pAAV-hSyn-ChRger3-TS-EYFP

    Plasmid

    #127240

    Purpose

    High photocurrent, low-light sensitive channelrhodopsin (ChRger3) for optogenetic activation with systemic delivery or for low-light activation. Driven by human Synapsin I promoter.

    Depositor

    Viviana Gradinaru

    Article

    Bedbrook et al Nat Methods. 2019 Oct 14. pii: 10.1038/s

    Insert

    ChRger3-TS-EYFP
    

    Use

    AAV

    Tags

    EYFP and SpyTag

    Expression

    Mammalian

    Promoter

    hSyn1

    Available Since

    Sept. 27, 2019

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge