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pRSV-Rev Citations (711)

Originally described in: A third-generation lentivirus vector with a conditional packaging system.
Dull T, Zufferey R, Kelly M, Mandel RJ, Nguyen M, Trono D, Naldini L J Virol. 1998 Nov . 72(11):8463-71.
PubMed

Articles Citing pRSV-Rev

Articles
Determination of the transforming activities of adenovirus oncogenes. Nevels M, Dobner T. Methods Mol Med. 2007;131:187-95. PubMed
Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus (KSHV) upregulates survivin expression in KSHV-Associated B-lymphoma cells and contributes to their proliferation. Lu J, Verma SC, Murakami M, Cai Q, Kumar P, Xiao B, Robertson ES. J Virol. 2009 Jul;83(14):7129-41. doi: 10.1128/JVI.00397-09. Epub 2009 May 13. PubMed
In vivo genetic manipulation of the rat trophoblast cell lineage using lentiviral vector delivery. Lee DS, Rumi MA, Konno T, Soares MJ. Genesis. 2009 Jul;47(7):433-9. doi: 10.1002/dvg.20518. PubMed
Gateway-compatible lentiviral transfer vectors for ubiquitin promoter driven expression of fluorescent fusion proteins. Krupka N, Strappe P, Götz J, Ittner LM. Plasmid. 2010 Feb 2. ():. PubMed

Associated Plasmids

The cell-specific induction of CXC chemokine ligand 9 mediated by IFN-gamma in microglia of the central nervous system is determined by the myeloid transcription factor PU.1. Ellis SL, Gysbers V, Manders PM, Li W, Hofer MJ, Muller M, Campbell IL. J Immunol. 2010 Aug 1;185(3):1864-77. doi: 10.4049/jimmunol.1000900. Epub 2010 Jun 28. PubMed
EGFR/Met association regulates EGFR TKI resistance in breast cancer. Mueller KL, Yang ZQ, Haddad R, Ethier SP, Boerner JL. J Mol Signal. 2010 Jul 12;5:8. doi: 10.1186/1750-2187-5-8. PubMed
The SR-BI partner PDZK1 facilitates hepatitis C virus entry. Eyre NS, Drummer HE, Beard MR. PLoS Pathog. 2010 Oct 7;6(10):e1001130. doi: 10.1371/journal.ppat.1001130. PubMed
Combining theoretical analysis and experimental data generation reveals IRF9 as a crucial factor for accelerating interferon alpha-induced early antiviral signalling. Maiwald T, Schneider A, Busch H, Sahle S, Gretz N, Weiss TS, Kummer U, Klingmuller U. FEBS J. 2010 Nov;277(22):4741-54. doi: 10.1111/j.1742-4658.2010.07880.x. Epub 2010 Oct 21. PubMed
Adenovirus membrane penetration activates the NLRP3 inflammasome. Barlan AU, Griffin TM, McGuire KA, Wiethoff CM. J Virol. 2011 Jan;85(1):146-55. doi: 10.1128/JVI.01265-10. Epub 2010 Oct 27. PubMed
Evidence that the lipid phosphatase SHIP-1 regulates T lymphocyte morphology and motility. Harris SJ, Parry RV, Foster JG, Blunt MD, Wang A, Marelli-Berg F, Westwick J, Ward SG. J Immunol. 2011 Apr 15;186(8):4936-45. doi: 10.4049/jimmunol.1002350. Epub 2011 Mar 14. PubMed
Lipid raft localization of EGFR alters the response of cancer cells to the EGFR tyrosine kinase inhibitor gefitinib. Irwin ME, Mueller KL, Bohin N, Ge Y, Boerner JL. J Cell Physiol. 2011 Sep;226(9):2316-28. doi: 10.1002/jcp.22570. PubMed
Adenovirus type 5 rupture of lysosomes leads to cathepsin B-dependent mitochondrial stress and production of reactive oxygen species. McGuire KA, Barlan AU, Griffin TM, Wiethoff CM. J Virol. 2011 Oct;85(20):10806-13. doi: 10.1128/JVI.00675-11. Epub 2011 Aug 10. PubMed
FOSL1 is integral to establishing the maternal-fetal interface. Kent LN, Rumi MA, Kubota K, Lee DS, Soares MJ. Mol Cell Biol. 2011 Dec;31(23):4801-13. doi: 10.1128/MCB.05780-11. Epub 2011 Sep 26. PubMed
The cyclin-like protein Spy1/RINGO promotes mammary transformation and is elevated in human breast cancer. Al Sorkhy M, Ferraiuolo RM, Jalili E, Malysa A, Fratiloiu AR, Sloane BF, Porter LA. BMC Cancer. 2012 Jan 26;12:45. doi: 10.1186/1471-2407-12-45. PubMed
RGB marking with lentiviral vectors for multicolor clonal cell tracking. Weber K, Thomaschewski M, Benten D, Fehse B. Nat Protoc. 2012 Apr 5;7(5):839-49. doi: 10.1038/nprot.2012.026. PubMed
Identification of the human PMR1 mRNA endonuclease as an alternatively processed product of the gene for peroxidasin-like protein. Gu SQ, Bakthavachalu B, Han J, Patil DP, Otsuka Y, Guda C, Schoenberg DR. RNA. 2012 Jun;18(6):1186-96. doi: 10.1261/rna.031369.111. Epub 2012 Apr 27. PubMed

Associated Plasmids

Inverted Alu dsRNA structures do not affect localization but can alter translation efficiency of human mRNAs independent of RNA editing. Capshew CR, Dusenbury KL, Hundley HA. Nucleic Acids Res. 2012 Sep 1;40(17):8637-45. Epub 2012 Jun 25. PubMed
Fibroblast-secreted hepatocyte growth factor mediates epidermal growth factor receptor tyrosine kinase inhibitor resistance in triple-negative breast cancers through paracrine activation of Met. Mueller KL, Madden JM, Zoratti GL, Kuperwasser C, List K, Boerner JL. Breast Cancer Res. 2012 Jul 12;14(4):R104. doi: 10.1186/bcr3224. PubMed
Human TSC-associated renal angiomyolipoma cells are hypersensitive to ER stress. Siroky BJ, Yin H, Babcock JT, Lu L, Hellmann AR, Dixon BP, Quilliam LA, Bissler JJ. Am J Physiol Renal Physiol. 2012 Sep 15;303(6):F831-44. doi: 10.1152/ajprenal.00441.2011. Epub 2012 Jul 11. PubMed
Loss of NF1 expression in human endothelial cells promotes autonomous proliferation and altered vascular morphogenesis. Bajaj A, Li QF, Zheng Q, Pumiglia K. PLoS One. 2012;7(11):e49222. doi: 10.1371/journal.pone.0049222. Epub 2012 Nov 7. PubMed
Patient-derived models of human breast cancer: protocols for in vitro and in vivo applications in tumor biology and translational medicine. DeRose YS, Gligorich KM, Wang G, Georgelas A, Bowman P, Courdy SJ, Welm AL, Welm BE. Curr Protoc Pharmacol. 2013 Mar;Chapter 14:Unit14.23. doi: 10.1002/0471141755.ph1423s60. PubMed
Sigma-1 receptor regulates early steps of viral RNA replication at the onset of hepatitis C virus infection. Friesland M, Mingorance L, Chung J, Chisari FV, Gastaminza P. J Virol. 2013 Jun;87(11):6377-90. doi: 10.1128/JVI.03557-12. Epub 2013 Mar 27. PubMed
A systematic approach to the establishment and characterization of endothelial progenitor cells for gene therapy. Werling NJ, Thorpe R, Zhao Y. Hum Gene Ther Methods. 2013 Jun;24(3):171-84. doi: 10.1089/hgtb.2012.146. Epub 2013 Apr 30. PubMed
Lipid droplet-binding protein TIP47 regulates hepatitis C Virus RNA replication through interaction with the viral NS5A protein. Vogt DA, Camus G, Herker E, Webster BR, Tsou CL, Greene WC, Yen TS, Ott M. PLoS Pathog. 2013;9(4):e1003302. doi: 10.1371/journal.ppat.1003302. Epub 2013 Apr 11. PubMed
Mammalian target of rapamycin complex 1 (mTORC1) enhances bortezomib-induced death in tuberous sclerosis complex (TSC)-null cells by a c-MYC-dependent induction of the unfolded protein response. Babcock JT, Nguyen HB, He Y, Hendricks JW, Wek RC, Quilliam LA. J Biol Chem. 2013 May 31;288(22):15687-98. doi: 10.1074/jbc.M112.431056. Epub 2013 Apr 23. PubMed
A robust method to derive functional neural crest cells from human pluripotent stem cells. Kreitzer FR, Salomonis N, Sheehan A, Huang M, Park JS, Spindler MJ, Lizarraga P, Weiss WA, So PL, Conklin BR. Am J Stem Cells. 2013 Jun 30;2(2):119-31. Print 2013. PubMed
Pid1 induces insulin resistance in both human and mouse skeletal muscle during obesity. Bonala S, McFarlane C, Ang J, Lim R, Lee M, Chua H, Lokireddy S, Sreekanth P, Leow MK, Meng KC, Shyong TE, Lee YS, Gluckman PD, Sharma M, Kambadur R. Mol Endocrinol. 2013 Sep;27(9):1518-35. doi: 10.1210/me.2013-1048. Epub 2013 Aug 8. PubMed
The zinc finger transcription factor ZXDC activates CCL2 gene expression by opposing BCL6-mediated repression. Ramsey JE, Fontes JD. Mol Immunol. 2013 Dec;56(4):768-80. doi: 10.1016/j.molimm.2013.07.001. Epub 2013 Aug 14. PubMed
Noninvasive visualization of tumor growth in a human colorectal liver metastases xenograft model using bioluminescence in vivo imaging. Thalheimer A, Korb D, Bonicke L, Wiegering A, Muhling B, Schneider M, Koch S, Riedel SS, Germer CT, Beilhack A, Brandlein S, Otto C. J Surg Res. 2013 Nov;185(1):143-51. doi: 10.1016/j.jss.2013.03.024. Epub 2013 Mar 30. PubMed
Determination of the transforming activities of adenovirus oncogenes. Speiseder T, Nevels M, Dobner T. Methods Mol Biol. 2014;1089:105-15. doi: 10.1007/978-1-62703-679-5_8. PubMed
Parallel measurement of dynamic changes in translation rates in single cells. Han K, Jaimovich A, Dey G, Ruggero D, Meyuhas O, Sonenberg N, Meyer T. Nat Methods. 2014 Jan;11(1):86-93. doi: 10.1038/nmeth.2729. Epub 2013 Nov 10. PubMed

Associated Plasmids

A tumor suppressor function for the lipid phosphatase INPP4B in melanocytic neoplasms. Perez-Lorenzo R, Gill KZ, Shen CH, Zhao FX, Zheng B, Schulze HJ, Silvers DN, Brunner G, Horst BA. J Invest Dermatol. 2014 May;134(5):1359-68. doi: 10.1038/jid.2013.511. Epub 2013 Nov 28. PubMed
Automated analysis of clonal cancer cells by intravital imaging. Coffey SE, Giedt RJ, Weissleder R. Intravital. 2013 Jul;2(3). doi: 10.4161/intv.26138. PubMed
A human torque teno virus encodes a microRNA that inhibits interferon signaling. Kincaid RP, Burke JM, Cox JC, de Villiers EM, Sullivan CS. PLoS Pathog. 2013;9(12):e1003818. doi: 10.1371/journal.ppat.1003818. Epub 2013 Dec 19. PubMed
The FOS transcription factor family differentially controls trophoblast migration and invasion. Renaud SJ, Kubota K, Rumi MA, Soares MJ. J Biol Chem. 2014 Feb 21;289(8):5025-39. doi: 10.1074/jbc.M113.523746. Epub 2013 Dec 30. PubMed
Generation of transgene-free mouse induced pluripotent stem cells using an excisable lentiviral system. Varga E, Nemes C, Davis RP, Ujhelly O, Klincumhom N, Polgar Z, Muenthaisong S, Pirity MK, Dinnyes A. Exp Cell Res. 2014 Apr 1;322(2):335-44. doi: 10.1016/j.yexcr.2014.02.006. Epub 2014 Feb 18. PubMed
Inter-cellular exchange of cellular components via VE-cadherin-dependent trans-endocytosis. Sakurai T, Woolls MJ, Jin SW, Murakami M, Simons M. PLoS One. 2014 Mar 6;9(6):e90736. doi: 10.1371/journal.pone.0090736. eCollection 2014. PubMed
The Hippo transducer TAZ interacts with the SWI/SNF complex to regulate breast epithelial lineage commitment. Skibinski A, Breindel JL, Prat A, Galvan P, Smith E, Rolfs A, Gupta PB, Labaer J, Kuperwasser C. Cell Rep. 2014 Mar 27;6(6):1059-72. doi: 10.1016/j.celrep.2014.02.038. Epub 2014 Mar 6. PubMed
MYPT1 regulates contractility and microtubule acetylation to modulate integrin adhesions and matrix assembly. Joo EE, Yamada KM. Nat Commun. 2014 Mar 25;5:3510. doi: 10.1038/ncomms4510. PubMed

Associated Plasmids

Transdifferentiation of mouse fibroblasts and hepatocytes to functional neurons. Marro S, Yang N. Methods Mol Biol. 2014;1150:237-46. doi: 10.1007/978-1-4939-0512-6_16. PubMed
FIH-1-Mint3 axis does not control HIF-1 transcriptional activity in nucleus pulposus cells. Hirose Y, Johnson ZI, Schoepflin ZR, Markova DZ, Chiba K, Toyama Y, Shapiro IM, Risbud MV. J Biol Chem. 2014 Jul 25;289(30):20594-605. PubMed
Live cell imaging of primary rat neonatal cardiomyocytes following adenoviral and lentiviral transduction using confocal spinning disk microscopy. Sakurai T, Lanahan A, Woolls MJ, Li N, Tirziu D, Murakami M. J Vis Exp. 2014 Jun 24;(88):e51666. doi: 10.3791/51666. PubMed
Lentiviral gene transduction of mouse and human hematopoietic stem cells. van Til NP, Wagemaker G. Methods Mol Biol. 2014;1185:311-9. doi: 10.1007/978-1-4939-1133-2_21. PubMed
StUbEx: Stable tagged ubiquitin exchange system for the global investigation of cellular ubiquitination. Akimov V, Henningsen J, Hallenborg P, Rigbolt KT, Jensen SS, Nielsen MM, Kratchmarova I, Blagoev B. J Proteome Res. 2014 Sep 5;13(9):4192-204. doi: 10.1021/pr500549h. Epub 2014 Aug 15. PubMed
Phosphorylation site dynamics of early T-cell receptor signaling. Chylek LA, Akimov V, Dengjel J, Rigbolt KT, Hu B, Hlavacek WS, Blagoev B. PLoS One. 2014 Aug 22;9(8):e104240. doi: 10.1371/journal.pone.0104240. eCollection 2014. PubMed
Pcgf6, a polycomb group protein, regulates mesodermal lineage differentiation in murine ESCs and functions in iPS reprogramming. Zdzieblo D, Li X, Lin Q, Zenke M, Illich DJ, Becker M, Muller AM. Stem Cells. 2014 Dec;32(12):3112-25. doi: 10.1002/stem.1826. PubMed
Lipid phosphate phosphatase-1 expression in cancer cells attenuates tumor growth and metastasis in mice. Tang X, Benesch MG, Dewald J, Zhao YY, Patwardhan N, Santos WL, Curtis JM, McMullen TP, Brindley DN. J Lipid Res. 2014 Nov;55(11):2389-400. doi: 10.1194/jlr.M053462. Epub 2014 Sep 10. PubMed
HBZ stimulates brain-derived neurotrophic factor/TrkB autocrine/paracrine signaling to promote survival of human T-cell leukemia virus type 1-Infected T cells. Polakowski N, Terol M, Hoang K, Nash I, Laverdure S, Gazon H, Belrose G, Mesnard JM, Cesaire R, Peloponese JM, Lemasson I. J Virol. 2014 Nov;88(22):13482-94. doi: 10.1128/JVI.02285-14. Epub 2014 Sep 10. PubMed
ETS1 is a genome-wide effector of RAS/ERK signaling in epithelial cells. Plotnik JP, Budka JA, Ferris MW, Hollenhorst PC. Nucleic Acids Res. 2014 Oct 29;42(19):11928-40. doi: 10.1093/nar/gku929. Epub 2014 Oct 7. PubMed
In vivo shRNA screens in solid tumors. Gargiulo G, Serresi M, Cesaroni M, Hulsman D, van Lohuizen M. Nat Protoc. 2014 Dec;9(12):2880-902. doi: 10.1038/nprot.2014.185. Epub 2014 Nov 20. PubMed
A role for the mitochondrial pyruvate carrier as a repressor of the Warburg effect and colon cancer cell growth. Schell JC, Olson KA, Jiang L, Hawkins AJ, Van Vranken JG, Xie J, Egnatchik RA, Earl EG, DeBerardinis RJ, Rutter J. Mol Cell. 2014 Nov 6;56(3):400-13. doi: 10.1016/j.molcel.2014.09.026. Epub 2014 Oct 21. PubMed
Deficiency in the mitochondrial apoptotic pathway reveals the toxic potential of autophagy under ER stress conditions. Deegan S, Saveljeva S, Logue SE, Pakos-Zebrucka K, Gupta S, Vandenabeele P, Bertrand MJ, Samali A. Autophagy. 2014;10(11):1921-36. doi: 10.4161/15548627.2014.981790. PubMed
Fanconi anemia gene editing by the CRISPR/Cas9 system. Osborn MJ, Gabriel R, Webber BR, DeFeo AP, McElroy AN, Jarjour J, Starker CG, Wagner JE, Joung JK, Voytas DF, von Kalle C, Schmidt M, Blazar BR, Tolar J. Hum Gene Ther. 2015 Feb;26(2):114-26. doi: 10.1089/hum.2014.111. PubMed
Endoplasmic reticulum stress induces ligand-independent TNFR1-mediated necroptosis in L929 cells. Saveljeva S, Mc Laughlin SL, Vandenabeele P, Samali A, Bertrand MJ. Cell Death Dis. 2015 Jan 8;6:e1587. doi: 10.1038/cddis.2014.548. PubMed
MicroRNA-22 regulates smooth muscle cell differentiation from stem cells by targeting methyl CpG-binding protein 2. Zhao H, Wen G, Huang Y, Yu X, Chen Q, Afzal TA, Luong le A, Zhu J, Ye S, Zhang L, Xiao Q. Arterioscler Thromb Vasc Biol. 2015 Apr;35(4):918-29. doi: 10.1161/ATVBAHA.114.305212. Epub 2015 Feb 26. PubMed
Innate immune response to Streptococcus pyogenes depends on the combined activation of TLR13 and TLR2. Fieber C, Janos M, Koestler T, Gratz N, Li XD, Castiglia V, Aberle M, Sauert M, Wegner M, Alexopoulou L, Kirschning CJ, Chen ZJ, von Haeseler A, Kovarik P. PLoS One. 2015 Mar 10;10(3):e0119727. doi: 10.1371/journal.pone.0119727. eCollection 2015. PubMed
Sustained regeneration of high-volume adipose tissue for breast reconstruction using computer aided design and biomanufacturing. Chhaya MP, Melchels FP, Holzapfel BM, Baldwin JG, Hutmacher DW. Biomaterials. 2015 Jun;52:551-60. doi: 10.1016/j.biomaterials.2015.01.025. Epub 2015 Mar 18. PubMed
Ebola Virus Glycoprotein Promotes Enhanced Viral Egress by Preventing Ebola VP40 From Associating With the Host Restriction Factor BST2/Tetherin. Gustin JK, Bai Y, Moses AV, Douglas JL. J Infect Dis. 2015 Mar 27. pii: jiv125. PubMed
Lentiviral vectors for retrograde delivery of recombinases and transactivators. Wickersham IR, Sullivan HA, Pao GM, Hamanaka H, Goosens KA, Verma IM, Seung HS. Cold Spring Harb Protoc. 2015 Apr 1;2015(4):368-74. doi: 10.1101/pdb.prot075879. PubMed
Repeated ER-endosome contacts promote endosome translocation and neurite outgrowth. Raiborg C, Wenzel EM, Pedersen NM, Olsvik H, Schink KO, Schultz SW, Vietri M, Nisi V, Bucci C, Brech A, Johansen T, Stenmark H. Nature. 2015 Apr 9;520(7546):234-8. doi: 10.1038/nature14359. PubMed
alpha6beta1- and alphaV-integrins are required for long-term self-renewal of murine embryonic stem cells in the absence of LIF. Cattavarayane S, Palovuori R, Tanjore Ramanathan J, Manninen A. BMC Cell Biol. 2015 Feb 27;16:3. doi: 10.1186/s12860-015-0051-y. PubMed
Ex vivo aorta patch model for analysis of cellular adhesion. Lin YN, Thata RN, Failla AV, Geissen M, Daum G, Windhorst S. Tissue Cell. 2015 Jun;47(3):266-72. doi: 10.1016/j.tice.2015.03.004. Epub 2015 Mar 23. PubMed
Single-step cloning-screening method: a new tool for developing and studying high-titer viral vector producer cells. Rodrigues AF, Formas-Oliveira AS, Guerreiro MR, Tomas HA, Alves PM, Coroadinha AS. Gene Ther. 2015 Sep;22(9):685-95. doi: 10.1038/gt.2015.44. Epub 2015 May 4. PubMed
Viral-mediated Labeling and Transplantation of Medial Ganglionic Eminence (MGE) Cells for In Vivo Studies. Vogt D, Wu PR, Sorrells SF, Arnold C, Alvarez-Buylla A, Rubenstein JL. J Vis Exp. 2015 Apr 23;(98). doi: 10.3791/52740. PubMed
An alternative pluripotent state confers interspecies chimaeric competency. Wu J, Okamura D, Li M, Suzuki K, Luo C, Ma L, He Y, Li Z, Benner C, Tamura I, Krause MN, Nery JR, Du T, Zhang Z, Hishida T, Takahashi Y, Aizawa E, Kim NY, Lajara J, Guillen P, Campistol JM, Esteban CR, Ross PJ, Saghatelian A, Ren B, Ecker JR, Izpisua Belmonte JC. Nature. 2015 May 21;521(7552):316-21. doi: 10.1038/nature14413. Epub 2015 May 6. PubMed
Comparative analysis of lentiviral vectors and modular protein nanovectors for traumatic brain injury gene therapy. Negro-Demontel ML, Saccardo P, Giacomini C, Yanez-Munoz RJ, Ferrer-Miralles N, Vazquez E, Villaverde A, Peluffo H. Mol Ther Methods Clin Dev. 2014 Oct 15;1:14047. doi: 10.1038/mtm.2014.47. eCollection 2014. PubMed
Akt signaling dynamics in individual cells. Gross SM, Rotwein P. J Cell Sci. 2015 Jun 3. pii: jcs.168773. PubMed

Associated Plasmids

Spastin and ESCRT-III coordinate mitotic spindle disassembly and nuclear envelope sealing. Vietri M, Schink KO, Campsteijn C, Wegner CS, Schultz SW, Christ L, Thoresen SB, Brech A, Raiborg C, Stenmark H. Nature. 2015 Jun 11;522(7555):231-5. doi: 10.1038/nature14408. Epub 2015 Jun 3. PubMed
Identification of bromodomain-containing protein-4 as a novel marker and epigenetic target in mast cell leukemia. Wedeh G, Cerny-Reiterer S, Eisenwort G, Herrmann H, Blatt K, Hadzijusufovic E, Sadovnik I, Mullauer L, Schwaab J, Hoffmann T, Bradner JE, Radia D, Sperr WR, Hoermann G, Reiter A, Horny HP, Zuber J, Arock M, Valent P. Leukemia. 2015 Jun 9. doi: 10.1038/leu.2015.138. PubMed
MYBL2 guides autophagy suppressor VDAC2 in the developing ovary to inhibit autophagy through a complex of VDAC2-BECN1-BCL2L1 in mammals. Yuan J, Zhang Y, Sheng Y, Fu X, Cheng H, Zhou R. Autophagy. 2015;11(7):1081-98. doi: 10.1080/15548627.2015.1040970. PubMed
More Tricks with Tetramers: A Practical Guide to Staining T cells with peptide-MHC Multimers. Dolton G, Tungatt K, Lloyd A, Bianchi V, Theaker SM, Trimby A, Holland CJ, Donia M, Godkin AJ, Cole DK, Straten PT, Peakman M, Svane IM, Sewell AK. Immunology. 2015 Jun 16. doi: 10.1111/imm.12499. PubMed
Lack of Rybp in Mouse Embryonic Stem Cells Impairs Cardiac Differentiation. Ujhelly O, Szabo V, Kovacs G, Vajda F, Mallok S, Prorok J, Acsai K, Hegedus Z, Krebs S, Dinnyes A, Pirity MK. Stem Cells Dev. 2015 Jun 25. PubMed
Drosophila homologue of Diaphanous 1 (DIAPH1) controls the metastatic potential of colon cancer cells by regulating microtubule-dependent adhesion. Lin YN, Bhuwania R, Gromova K, Failla AV, Lange T, Riecken K, Linder S, Kneussel M, Izbicki JR, Windhorst S. Oncotarget. 2015 Jul 30;6(21):18577-89. PubMed
NKX2-5 mutations causative for congenital heart disease retain functionality and are directed to hundreds of targets. Bouveret R, Waardenberg AJ, Schonrock N, Ramialison M, Doan T, de Jong D, Bondue A, Kaur G, Mohamed S, Fonoudi H, Chen CM, Wouters MA, Bhattacharya S, Plachta N, Dunwoodie SL, Chapman G, Blanpain C, Harvey RP. Elife. 2015 Jul 6;4. doi: 10.7554/eLife.06942. PubMed

Associated Plasmids

Exosome-mediated microRNA signaling from breast cancer cells is altered by the anti-angiogenesis agent docosahexaenoic acid (DHA). Hannafon BN, Carpenter KJ, Berry WL, Janknecht R, Dooley WC, Ding WQ. Mol Cancer. 2015 Jul 16;14:133. doi: 10.1186/s12943-015-0400-7. PubMed
RhoB upregulation leads to either apoptosis or cytostasis through differential target selection. Marlow LA, Bok I, Smallridge RC, Copland JA. Endocr Relat Cancer. 2015 Oct;22(5):777-92. doi: 10.1530/ERC-14-0302. Epub 2015 Jul 23. PubMed
Scalable Electrophysiological Investigation of iPS Cell-Derived Cardiomyocytes Obtained by a Lentiviral Purification Strategy. Friedrichs S, Malan D, Voss Y, Sasse P. J Clin Med. 2015 Jan 8;4(1):102-23. doi: 10.3390/jcm4010102. PubMed
Separating myoblast differentiation from muscle cell fusion using IGF-I and the p38 MAP kinase inhibitor SB202190. Gardner S, Gross SM, David LL, Klimek JE, Rotwein P. Am J Physiol Cell Physiol. 2015 Oct 1;309(7):C491-500. doi: 10.1152/ajpcell.00184.2015. Epub 2015 Aug 5. PubMed
The Interferon-induced Transmembrane Proteins, IFITM1, IFITM2, and IFITM3 Inhibit Hepatitis C Virus Entry. Narayana SK, Helbig KJ, McCartney EM, Eyre NS, Bull RA, Eltahla A, Lloyd AR, Beard MR. J Biol Chem. 2015 Oct 23;290(43):25946-59. doi: 10.1074/jbc.M115.657346. Epub 2015 Sep 9. PubMed
CRISPR/Cas9 System as an Agent for Eliminating Polyomavirus JC Infection. Wollebo HS, Bellizzi A, Kaminski R, Hu W, White MK, Khalili K. PLoS One. 2015 Sep 11;10(9):e0136046. doi: 10.1371/journal.pone.0136046. eCollection 2015. PubMed
Exogenous marker-engineered mesenchymal stem cells detect cancer and metastases in a simple blood assay. Liu L, Zhang SX, Aeran R, Liao W, Lu M, Polovin G, Pone EJ, Zhao W. Stem Cell Res Ther. 2015 Sep 21;6:181. doi: 10.1186/s13287-015-0151-9. PubMed
Succination is Increased on Select Proteins in the Brainstem of the NADH dehydrogenase (ubiquinone) Fe-S protein 4 (Ndufs4) Knockout Mouse, a Model of Leigh Syndrome. Piroli GG, Manuel AM, Clapper AC, Walla MD, Baatz JE, Palmiter RD, Quintana A, Frizzell N. Mol Cell Proteomics. 2016 Feb;15(2):445-61. doi: 10.1074/mcp.M115.051516. Epub 2015 Oct 8. PubMed
The role of APC/C in replication stress and origin of genomic instability. Greil C, Krohs J, Schnerch D, Follo M, Felthaus J, Engelhardt M, Wasch R. Oncogene. 2015 Oct 12. doi: 10.1038/onc.2015.367. PubMed
Differentiation of human ESCs to retinal ganglion cells using a CRISPR engineered reporter cell line. Sluch VM, Davis CH, Ranganathan V, Kerr JM, Krick K, Martin R, Berlinicke CA, Marsh-Armstrong N, Diamond JS, Mao HQ, Zack DJ. Sci Rep. 2015 Nov 13;5:16595. doi: 10.1038/srep16595. PubMed
Non-epigenetic function of HDAC8 in regulating breast cancer stem cells by maintaining Notch1 protein stability. Chao MW, Chu PC, Chuang HC, Shen FH, Chou CC, Hsu EC, Himmel LE, Huang HL, Tu HJ, Kulp SK, Teng CM, Chen CS. Oncotarget. 2016 Jan 12;7(2):1796-807. doi: 10.18632/oncotarget.6427. PubMed
C/EBPgamma is a critical regulator of cellular stress response networks through heterodimerization with ATF4. Huggins CJ, Mayekar MK, Martin N, Saylor KL, Gonit M, Jailwala P, Kasoji M, Haines DC, Quinones OA, Johnson PF. Mol Cell Biol. 2015 Dec 14. pii: MCB.00911-15. PubMed
Long-acting cocaine hydrolase for addiction therapy. Chen X, Xue L, Hou S, Jin Z, Zhang T, Zheng F, Zhan CG. Proc Natl Acad Sci U S A. 2016 Jan 12;113(2):422-7. doi: 10.1073/pnas.1517713113. Epub 2015 Dec 28. PubMed
A Conserved Interaction between a C-Terminal Motif in Norovirus VPg and the HEAT-1 Domain of eIF4G Is Essential for Translation Initiation. Leen EN, Sorgeloos F, Correia S, Chaudhry Y, Cannac F, Pastore C, Xu Y, Graham SC, Matthews SJ, Goodfellow IG, Curry S. PLoS Pathog. 2016 Jan 6;12(1):e1005379. doi: 10.1371/journal.ppat.1005379. eCollection 2016 Jan. PubMed
NBR1 enables autophagy-dependent focal adhesion turnover. Kenific CM, Stehbens SJ, Goldsmith J, Leidal AM, Faure N, Ye J, Wittmann T, Debnath J. J Cell Biol. 2016 Feb 29;212(5):577-590. Epub 2016 Feb 22. PubMed

Associated Plasmids

Integrin-linked kinase as a novel molecular switch of the IL-6-NF-kappaB signaling loop in breast cancer. Hsu EC, Kulp SK, Huang HL, Tu HJ, Chao MW, Tseng YC, Yang MC, Salunke SB, Sullivan NJ, Chen WC, Zhang J, Teng CM, Fu WM, Sun D, Wicha MS, Shapiro CL, Chen CS. Carcinogenesis. 2016 Apr;37(4):430-42. doi: 10.1093/carcin/bgw020. Epub 2016 Feb 19. PubMed
Neuronal Orphan G-Protein Coupled Receptor Proteins Mediate Plasmalogens-Induced Activation of ERK and Akt Signaling. Hossain MS, Mineno K, Katafuchi T. PLoS One. 2016 Mar 2;11(3):e0150846. doi: 10.1371/journal.pone.0150846. eCollection 2016. PubMed
Editing of mouse and human immunoglobulin genes by CRISPR-Cas9 system. Cheong TC, Compagno M, Chiarle R. Nat Commun. 2016 Mar 9;7:10934. doi: 10.1038/ncomms10934. PubMed
Stable and Efficient Genetic Modification of Cells in the Adult Mouse V-SVZ for the Analysis of Neural Stem Cell Autonomous and Non-autonomous Effects. Porlan E, Marti-Prado B, Consiglio A, Farinas I. J Vis Exp. 2016 Feb 17;(108). doi: 10.3791/53282. PubMed
Development of Third-generation Cocal Envelope Producer Cell Lines for Robust Lentiviral Gene Transfer into Hematopoietic Stem Cells and T-cells. Humbert O, Gisch DW, Wohlfahrt ME, Adams AB, Greenberg PD, Schmitt TM, Trobridge GD, Kiem HP. Mol Ther. 2016 May 24. doi: 10.1038/mt.2016.70. PubMed
ExtraPEG: A Polyethylene Glycol-Based Method for Enrichment of Extracellular Vesicles. Rider MA, Hurwitz SN, Meckes DG Jr. Sci Rep. 2016 Apr 12;6:23978. doi: 10.1038/srep23978. PubMed
Development of Rabies Virus-Like Particles for Vaccine Applications: Production, Characterization, and Protection Studies. Fontana D, Etcheverrigaray M, Kratje R, Prieto C. Methods Mol Biol. 2016;1403:155-66. doi: 10.1007/978-1-4939-3387-7_7. PubMed
Analysis of Nuclear Lamina Proteins in Myoblast Differentiation by Functional Complementation. Tapia O, Gerace L. Methods Mol Biol. 2016;1411:177-94. doi: 10.1007/978-1-4939-3530-7_11. PubMed
MYC Is a Crucial Mediator of TGFbeta-Induced Invasion in Basal Breast Cancer. Cichon MA, Moruzzi ME, Shqau TA, Miller E, Mehner C, Ethier SP, Copland JA, Radisky ES, Radisky DC. Cancer Res. 2016 Jun 15;76(12):3520-30. doi: 10.1158/0008-5472.CAN-15-3465. Epub 2016 Apr 13. PubMed
Forced expression of Hnf4a induces hepatic gene activation through directed differentiation. Yahoo N, Pournasr B, Rostamzadeh J, Fathi F. Biochem Biophys Res Commun. 2016 Aug 5;476(4):313-8. doi: 10.1016/j.bbrc.2016.05.119. Epub 2016 May 24. PubMed
shRNA-Induced Gene Knockdown In Vivo to Investigate Neutrophil Function. Basit A, Tang W, Wu D. Methods Mol Biol. 2016;1407:169-77. doi: 10.1007/978-1-4939-3480-5_13. PubMed
The C9orf72 protein interacts with Rab1a and the ULK1 complex to regulate initiation of autophagy. Webster CP, Smith EF, Bauer CS, Moller A, Hautbergue GM, Ferraiuolo L, Myszczynska MA, Higginbottom A, Walsh MJ, Whitworth AJ, Kaspar BK, Meyer K, Shaw PJ, Grierson AJ, De Vos KJ. EMBO J. 2016 Jun 22. pii: e201694401. PubMed
Angiopoietin-2 promotes ER+ breast cancer cell survival in bone marrow niche. Han HH, Kim BG, Lee JH, Kang S, Kim JE, Cho NH. Endocr Relat Cancer. 2016 Aug;23(8):609-23. doi: 10.1530/ERC-16-0086. Epub 2016 Jun 27. PubMed
A PBX1 transcriptional network controls dopaminergic neuron development and is impaired in Parkinson's disease. Villaescusa JC, Li B, Toledo EM, Rivetti di Val Cervo P, Yang S, Stott SR, Kaiser K, Islam S, Gyllborg D, Laguna-Goya R, Landreh M, Lonnerberg P, Falk A, Bergman T, Barker RA, Linnarsson S, Selleri L, Arenas E. EMBO J. 2016 Sep 15;35(18):1963-78. doi: 10.15252/embj.201593725. Epub 2016 Jun 28. PubMed
Evaluation of Immortalized AVPV- and Arcuate-Specific Neuronal Kisspeptin Cell Lines to Elucidate Potential Mechanisms of Estrogen Responsiveness and Temporal Gene Expression in Females. Jacobs DC, Veitch RE, Chappell PE. Endocrinology. 2016 Sep;157(9):3410-9. doi: 10.1210/en.2016-1294. Epub 2016 Jul 13. PubMed
Human ULK1 Variation and Susceptibility to Mycobacterium tuberculosis Infection. Horne DJ, Graustein AD, Shah JA, Peterson G, Savlov M, Steele S, Narita M, Hawn TR. J Infect Dis. 2016 Oct 15;214(8):1260-7. doi: 10.1093/infdis/jiw347. Epub 2016 Aug 2. PubMed
Optimal Lentivirus Production and Cell Culture Conditions Necessary to Successfully Transduce Primary Human Bronchial Epithelial Cells. Baumlin-Schmid N, Salathe M, Fregien NL. J Vis Exp. 2016 Jul 22;(113). doi: 10.3791/54176. PubMed
STAT3-induced WDR1 overexpression promotes breast cancer cell migration. Lee JH, Kim JE, Kim BG, Han HH, Kang S, Cho NH. Cell Signal. 2016 Nov;28(11):1753-60. doi: 10.1016/j.cellsig.2016.08.006. Epub 2016 Aug 10. PubMed
Negative Feedback Regulation of HIV-1 by Gene Editing Strategy. Kaminski R, Chen Y, Salkind J, Bella R, Young WB, Ferrante P, Karn J, Malcolm T, Hu W, Khalili K. Sci Rep. 2016 Aug 16;6:31527. doi: 10.1038/srep31527. PubMed
Exposure to human immunodeficiency virus/hepatitis C virus in hepatic and stellate cell lines reveals cooperative profibrotic transcriptional activation between viruses and cell types. Salloum S, Holmes JA, Jindal R, Bale SS, Brisac C, Alatrakchi N, Lidofsky A, Kruger AJ, Fusco DN, Luther J, Schaefer EA, Lin W, Yarmush ML, Chung RT. Hepatology. 2016 Dec;64(6):1951-1968. doi: 10.1002/hep.28766. Epub 2016 Oct 5. PubMed
Functional receptor molecules CD300lf and CD300ld within the CD300 family enable murine noroviruses to infect cells. Haga K, Fujimoto A, Takai-Todaka R, Miki M, Doan YH, Murakami K, Yokoyama M, Murata K, Nakanishi A, Katayama K. Proc Natl Acad Sci U S A. 2016 Oct 11;113(41):E6248-E6255. Epub 2016 Sep 28. PubMed
The A2b adenosine receptor antagonist PSB-603 promotes oxidative phosphorylation and ROS production in colorectal cancer cells via adenosine receptor-independent mechanism. Molck C, Ryall J, Failla LM, Coates JL, Pascussi JM, Heath JK, Stewart G, Hollande F. Cancer Lett. 2016 Dec 1;383(1):135-143. doi: 10.1016/j.canlet.2016.09.018. Epub 2016 Sep 28. PubMed
LDB1 overexpression is a negative prognostic factor in colorectal cancer. Garcia SA, Swiersy A, Radhakrishnan P, Branchi V, Kanth Nanduri L, Gyorffy B, Betzler AM, Bork U, Kahlert C, Reissfelder C, Rahbari NN, Weitz J, Scholch S. Oncotarget. 2016 Dec 20;7(51):84258-84270. doi: 10.18632/oncotarget.12481. PubMed
Snail1-dependent p53 repression regulates expansion and activity of tumour-initiating cells in breast cancer. Ni T, Li XY, Lu N, An T, Liu ZP, Fu R, Lv WC, Zhang YW, Xu XJ, Grant Rowe R, Lin YS, Scherer A, Feinberg T, Zheng XQ, Chen BA, Liu XS, Guo QL, Wu ZQ, Weiss SJ. Nat Cell Biol. 2016 Nov;18(11):1221-1232. doi: 10.1038/ncb3425. Epub 2016 Oct 17. PubMed
Mechanisms of leukemia resistance to antibody dependent cellular cytotoxicity. Dubrovsky L, Brea EJ, Pankov D, Casey E, Dao T, Liu C, Scheinberg DA. Oncoimmunology. 2016 Aug 3;5(9):e1211221. eCollection 2016. PubMed
Genetically Engineered Macrophages: A Potential Platform for Cancer Immunotherapy. Moyes KW, Lieberman NA, Kreuser SA, Chinn H, Winter C, Deutsch G, Hoglund V, Watson R, Crane CA. Hum Gene Ther. 2016 Oct 18. PubMed
MIR144* inhibits antimicrobial responses against Mycobacterium tuberculosis in human monocytes and macrophages by targeting the autophagy protein DRAM2. Kim JK, Lee HM, Park KS, Shin DM, Kim TS, Kim YS, Suh HW, Kim SY, Kim IS, Kim JM, Son JW, Sohn KM, Jung SS, Chung C, Han SB, Yang CS, Jo EK. Autophagy. 2016 Oct 20:1-19. doi: 10.1080/15548627.2016.1241922. PubMed
The Hippo pathway regulates human megakaryocytic differentiation. Lorthongpanich C, Jiamvoraphong N, Supraditaporn K, Klaihmon P, U-Pratya Y, Issaragrisil S. Thromb Haemost. 2017 Jan 5;117(1):116-126. doi: 10.1160/TH16-07-0564. Epub 2016 Oct 27. PubMed
The Andes Virus Nucleocapsid Protein Directs Basal Endothelial Cell Permeability by Activating RhoA. Gorbunova EE, Simons MJ, Gavrilovskaya IN, Mackow ER. MBio. 2016 Oct 25;7(5). pii: e01747-16. doi: 10.1128/mBio.01747-16. PubMed
HIF-KDM3A-MMP12 regulatory circuit ensures trophoblast plasticity and placental adaptations to hypoxia. Chakraborty D, Cui W, Rosario GX, Scott RL, Dhakal P, Renaud SJ, Tachibana M, Rumi MA, Mason CW, Krieg AJ, Soares MJ. Proc Natl Acad Sci U S A. 2016 Nov 15;113(46):E7212-E7221. Epub 2016 Nov 2. PubMed
Cellular effects of fluorodeoxyglucose: Global changes in the lipidome and alteration in intracellular transport. Kavaliauskiene S, Torgersen ML, Lingelem AB, Klokk TI, Lintonen T, Simolin H, Ekroos K, Skotland T, Sandvig K. Oncotarget. 2016 Nov 29;7(48):79885-79900. doi: 10.18632/oncotarget.13089. PubMed
Notch regulates BMP responsiveness and lateral branching in vessel networks via SMAD6. Mouillesseaux KP, Wiley DS, Saunders LM, Wylie LA, Kushner EJ, Chong DC, Citrin KM, Barber AT, Park Y, Kim JD, Samsa LA, Kim J, Liu J, Jin SW, Bautch VL. Nat Commun. 2016 Nov 11;7:13247. doi: 10.1038/ncomms13247. PubMed
In vivo genome editing via CRISPR/Cas9 mediated homology-independent targeted integration. Suzuki K, Tsunekawa Y, Hernandez-Benitez R, Wu J, Zhu J, Kim EJ, Hatanaka F, Yamamoto M, Araoka T, Li Z, Kurita M, Hishida T, Li M, Aizawa E, Guo S, Chen S, Goebl A, Soligalla RD, Qu J, Jiang T, Fu X, Jafari M, Esteban CR, Berggren WT, Lajara J, Nunez-Delicado E, Guillen P, Campistol JM, Matsuzaki F, Liu GH, Magistretti P, Zhang K, Callaway EM, Zhang K, Belmonte JC. Nature. 2016 Dec 1;540(7631):144-149. doi: 10.1038/nature20565. Epub 2016 Nov 16. PubMed

Associated Plasmids

miRNAsong: a web-based tool for generation and testing of miRNA sponge constructs in silico. Barta T, Peskova L, Hampl A. Sci Rep. 2016 Nov 18;6:36625. doi: 10.1038/srep36625. PubMed
The anti-tumor drug 2-hydroxyoleic acid (Minerval) stimulates signaling and retrograde transport. Torgersen ML, Klokk TI, Kavaliauskiene S, Klose C, Simons K, Skotland T, Sandvig K. Oncotarget. 2016 Dec 27;7(52):86871-86888. doi: 10.18632/oncotarget.13508. PubMed
ICAM-5/Telencephalin Is a Functional Entry Receptor for Enterovirus D68. Wei W, Guo H, Chang J, Yu Y, Liu G, Zhang N, Willard SH, Zheng S, Yu XF. Cell Host Microbe. 2016 Nov 9;20(5):631-641. doi: 10.1016/j.chom.2016.09.013. Epub 2016 Oct 27. PubMed
Monitoring Synapses Via Trans-Synaptic GFP Complementation. Tsetsenis T. Methods Mol Biol. 2017;1538:45-52. PubMed
Caspase-2-mediated cell death is required for deleting aneuploid cells. Dawar S, Lim Y, Puccini J, White M, Thomas P, Bouchier-Hayes L, Green DR, Dorstyn L, Kumar S. Oncogene. 2016 Dec 19. doi: 10.1038/onc.2016.423. PubMed
A Photoactivatable Innate Immune Receptor for Optogenetic Inflammation. Moser BA, Esser-Kahn AP. ACS Chem Biol. 2016 Dec 29. doi: 10.1021/acschembio.6b01012. PubMed
An enzymatic assay based on luciferase Ebola virus-like particles for evaluation of virolytic activity of antimicrobial peptides. Peskova M, Heger Z, Janda P, Adam V, Pekarik V. Peptides. 2016 Dec 22;88:87-96. doi: 10.1016/j.peptides.2016.12.015. PubMed
Non-human Primate Schlafen11 Inhibits Production of Both Host and Viral Proteins. Stabell AC, Hawkins J, Li M, Gao X, David M, Press WH, Sawyer SL. PLoS Pathog. 2016 Dec 27;12(12):e1006066. doi: 10.1371/journal.ppat.1006066. eCollection 2016 Dec. PubMed
De-immunized and Functional Therapeutic (DeFT) versions of a long lasting recombinant alpha interferon for antiviral therapy. Mufarrege EF, Giorgetti S, Etcheverrigaray M, Terry F, Martin W, De Groot AS. Clin Immunol. 2017 Jan 10;176:31-41. doi: 10.1016/j.clim.2017.01.003. PubMed
Human AML-iPSCs Reacquire Leukemic Properties after Differentiation and Model Clonal Variation of Disease. Chao MP, Gentles AJ, Chatterjee S, Lan F, Reinisch A, Corces MR, Xavy S, Shen J, Haag D, Chanda S, Sinha R, Morganti RM, Nishimura T, Ameen M, Wu H, Wernig M, Wu JC, Majeti R. Cell Stem Cell. 2017 Mar 2;20(3):329-344.e7. doi: 10.1016/j.stem.2016.11.018. Epub 2017 Jan 12. PubMed
Pooled CRISPR screening with single-cell transcriptome readout. Datlinger P, Rendeiro AF, Schmidl C, Krausgruber T, Traxler P, Klughammer J, Schuster LC, Kuchler A, Alpar D, Bock C. Nat Methods. 2017 Jan 18. doi: 10.1038/nmeth.4177. PubMed

Associated Plasmids

Interaction with ZMYND11 mediates opposing roles of Ras-responsive transcription factors ETS1 and ETS2. Plotnik JP, Hollenhorst PC. Nucleic Acids Res. 2017 May 5;45(8):4452-4462. doi: 10.1093/nar/gkx039. PubMed
Interspecies Chimerism with Mammalian Pluripotent Stem Cells. Wu J, Platero-Luengo A, Sakurai M, Sugawara A, Gil MA, Yamauchi T, Suzuki K, Bogliotti YS, Cuello C, Morales Valencia M, Okumura D, Luo J, Vilarino M, Parrilla I, Soto DA, Martinez CA, Hishida T, Sanchez-Bautista S, Martinez-Martinez ML, Wang H, Nohalez A, Aizawa E, Martinez-Redondo P, Ocampo A, Reddy P, Roca J, Maga EA, Esteban CR, Berggren WT, Nunez Delicado E, Lajara J, Guillen I, Guillen P, Campistol JM, Martinez EA, Ross PJ, Izpisua Belmonte JC. Cell. 2017 Jan 26;168(3):473-486.e15. doi: 10.1016/j.cell.2016.12.036. PubMed
Inhibition of serotonin receptor type 1 in acute myeloid leukemia impairs leukemia stem cell functionality: a promising novel therapeutic target. Etxabe A, Lara-Castillo MC, Cornet-Masana JM, Banus-Mulet A, Nomdedeu M, Torrente MA, Pratcorona M, Diaz-Beya M, Esteve J, Risueno RM. Leukemia. 2017 Nov;31(11):2288-2302. doi: 10.1038/leu.2017.52. Epub 2017 Feb 14. PubMed
Reduction of Ether-Type Glycerophospholipids, Plasmalogens, by NF-kappaB Signal Leading to Microglial Activation. Hossain MS, Abe Y, Ali F, Youssef M, Honsho M, Fujiki Y, Katafuchi T. J Neurosci. 2017 Apr 12;37(15):4074-4092. doi: 10.1523/JNEUROSCI.3941-15.2017. Epub 2017 Mar 14. PubMed
Genetic and pharmacological inhibition of TTK impairs pancreatic cancer cell line growth by inducing lethal chromosomal instability. Stratford JK, Yan F, Hill RA, Major MB, Graves LM, Der CJ, Yeh JJ. PLoS One. 2017 Apr 5;12(4):e0174863. doi: 10.1371/journal.pone.0174863. eCollection 2017. PubMed
Induced Pluripotent Stem Cell Differentiation Enables Functional Validation of GWAS Variants in Metabolic Disease. Warren CR, O'Sullivan JF, Friesen M, Becker CE, Zhang X, Liu P, Wakabayashi Y, Morningstar JE, Shi X, Choi J, Xia F, Peters DT, Florido MHC, Tsankov AM, Duberow E, Comisar L, Shay J, Jiang X, Meissner A, Musunuru K, Kathiresan S, Daheron L, Zhu J, Gerszten RE, Deo RC, Vasan RS, O'Donnell CJ, Cowan CA. Cell Stem Cell. 2017 Apr 6;20(4):547-557.e7. doi: 10.1016/j.stem.2017.01.010. PubMed
Induction of functional dopamine neurons from human astrocytes in vitro and mouse astrocytes in a Parkinson's disease model. Rivetti di Val Cervo P, Romanov RA, Spigolon G, Masini D, Martin-Montanez E, Toledo EM, La Manno G, Feyder M, Pifl C, Ng YH, Sanchez SP, Linnarsson S, Wernig M, Harkany T, Fisone G, Arenas E. Nat Biotechnol. 2017 May;35(5):444-452. doi: 10.1038/nbt.3835. Epub 2017 Apr 10. PubMed
Synthesis and Degradation of Adenosine 5'-Tetraphosphate by Nicotinamide and Nicotinate Phosphoribosyltransferases. Amici A, Grolla AA, Del Grosso E, Bellini R, Bianchi M, Travelli C, Garavaglia S, Sorci L, Raffaelli N, Ruggieri S, Genazzani AA, Orsomando G. Cell Chem Biol. 2017 May 18;24(5):553-564.e4. doi: 10.1016/j.chembiol.2017.03.010. Epub 2017 Apr 13. PubMed
Effects of altered sialic acid biosynthesis on N-linked glycan branching and cell surface interactions. Pham ND, Pang PC, Krishnamurthy S, Wands AM, Grassi P, Dell A, Haslam SM, Kohler JJ. J Biol Chem. 2017 Jun 9;292(23):9637-9651. doi: 10.1074/jbc.M116.764597. Epub 2017 Apr 19. PubMed
Integrase-Deficient Lentiviral Vector as an All-in-One Platform for Highly Efficient CRISPR/Cas9-Mediated Gene Editing. Ortinski PI, O'Donovan B, Dong X, Kantor B. Mol Ther Methods Clin Dev. 2017 Apr 19;5:153-164. doi: 10.1016/j.omtm.2017.04.002. eCollection 2017 Jun 16. PubMed
Glucose Can Epigenetically Alter the Gene Expression of Neurotrophic Factors in the Murine Brain Cells. Hossain MS, Oomura Y, Katafuchi T. Mol Neurobiol. 2017 May 13. doi: 10.1007/s12035-017-0578-3. PubMed
Role of peptidylarginine deiminase 2 (PAD2) in mammary carcinoma cell migration. Horibata S, Rogers KE, Sadegh D, Anguish LJ, McElwee JL, Shah P, Thompson PR, Coonrod SA. BMC Cancer. 2017 May 26;17(1):378. doi: 10.1186/s12885-017-3354-x. PubMed
Knockdown of sodium-calcium exchanger 1 induces epithelial-to-mesenchymal transition in kidney epithelial cells. Balasubramaniam SL, Gopalakrishnapillai A, Petrelli NJ, Barwe SP. J Biol Chem. 2017 Jul 7;292(27):11388-11399. doi: 10.1074/jbc.M116.752352. Epub 2017 May 26. PubMed
PI3K class II alpha regulates delta-opioid receptor export from the trans-Golgi network. Shiwarski DJ, Darr M, Telmer CA, Bruchez MP, Puthenveedu MA. Mol Biol Cell. 2017 Aug 1;28(16):2202-2219. doi: 10.1091/mbc.E17-01-0030. Epub 2017 May 31. PubMed
Generation of Induced Pluripotent Stem Cells in Defined Three-Dimensional Hydrogels. Caiazzo M, Tabata Y, Lutolf M. Methods Mol Biol. 2017;1612:65-78. doi: 10.1007/978-1-4939-7021-6_5. PubMed
Role of integrin-linked kinase in regulating the protein stability of the MUC1-C oncoprotein in pancreatic cancer cells. Huang HL, Wu HY, Chu PC, Lai IL, Huang PH, Kulp SK, Pan SL, Teng CM, Chen CS. Oncogenesis. 2017 Jul 10;6(7):e359. doi: 10.1038/oncsis.2017.61. PubMed
Manipulation of nuclear architecture through CRISPR-mediated chromosomal looping. Morgan SL, Mariano NC, Bermudez A, Arruda NL, Wu F, Luo Y, Shankar G, Jia L, Chen H, Hu JF, Hoffman AR, Huang CC, Pitteri SJ, Wang KC. Nat Commun. 2017 Jul 13;8:15993. doi: 10.1038/ncomms15993. PubMed
CRISPR/Cas9-Mediated Scanning for Regulatory Elements Required for HPRT1 Expression via Thousands of Large, Programmed Genomic Deletions. Gasperini M, Findlay GM, McKenna A, Milbank JH, Lee C, Zhang MD, Cusanovich DA, Shendure J. Am J Hum Genet. 2017 Aug 3;101(2):192-205. doi: 10.1016/j.ajhg.2017.06.010. Epub 2017 Jul 14. PubMed
Intratumoral Lentivector-Mediated TGF-beta1 Gene Downregulation As a Potent Strategy for Enhancing the Antitumor Effect of Therapy Composed of Cyclophosphamide and Dendritic Cells. Rossowska J, Anger N, Szczygiel A, Mierzejewska J, Pajtasz-Piasecka E. Front Immunol. 2017 Jun 30;8:713. doi: 10.3389/fimmu.2017.00713. eCollection 2017. PubMed
Development of Hepatocyte-like Cell Derived from Human Induced Pluripotent Stem cell as a Host for Clinically Isolated Hepatitis C Virus. Sa-Ngiamsuntorn K, Hongeng S, Wongkajornsilp A. Curr Protoc Stem Cell Biol. 2017 Aug 14;42:4A.13.1-4A.13.34. doi: 10.1002/cpsc.35. PubMed
ESRRA (estrogen-related receptor alpha) is a key coordinator of transcriptional and post-translational activation of autophagy to promote innate host defense. Kim SY, Yang CS, Lee HM, Kim JK, Kim YS, Kim YR, Kim JS, Kim TS, Yuk JM, Dufour CR, Lee SH, Kim JM, Choi HS, Giguere V, Jo EK. Autophagy. 2018;14(1):152-168. doi: 10.1080/15548627.2017.1339001. Epub 2017 Sep 1. PubMed
Palmitoylation of the ciliary GTPase ARL13b is necessary for its stability and its role in cilia formation. Roy K, Jerman S, Jozsef L, McNamara T, Onyekaba G, Sun Z, Marin EP. J Biol Chem. 2017 Oct 27;292(43):17703-17717. doi: 10.1074/jbc.M117.792937. Epub 2017 Aug 28. PubMed
Assessment of selected media supplements to improve F/HN lentiviral vector production yields. Gelinas JF, Davies LA, Gill DR, Hyde SC. Sci Rep. 2017 Aug 31;7(1):10198. doi: 10.1038/s41598-017-07893-3. PubMed
Replacing reprogramming factors with antibodies selected from combinatorial antibody libraries. Blanchard JW, Xie J, El-Mecharrafie N, Gross S, Lee S, Lerner RA, Baldwin KK. Nat Biotechnol. 2017 Oct;35(10):960-968. doi: 10.1038/nbt.3963. Epub 2017 Sep 11. PubMed
Optimized PEI-based Transfection Method for Transient Transfection and Lentiviral Production. Yang S, Zhou X, Li R, Fu X, Sun P. Curr Protoc Chem Biol. 2017 Sep 14;9(3):147-157. doi: 10.1002/cpch.25. PubMed
SIDT2 Transports Extracellular dsRNA into the Cytoplasm for Innate Immune Recognition. Nguyen TA, Smith BRC, Tate MD, Belz GT, Barrios MH, Elgass KD, Weisman AS, Baker PJ, Preston SP, Whitehead L, Garnham A, Lundie RJ, Smyth GK, Pellegrini M, O'Keeffe M, Wicks IP, Masters SL, Hunter CP, Pang KC. Immunity. 2017 Sep 19;47(3):498-509.e6. doi: 10.1016/j.immuni.2017.08.007. Epub 2017 Sep 12. PubMed
Strategies to Develop Therapeutic N- and O-Hyperglycosylated Proteins. Gugliotta A, Ceaglio N, Etcheverrigaray M, Kratje R, Oggero M. Methods Mol Biol. 2018;1674:163-181. doi: 10.1007/978-1-4939-7312-5_13. PubMed
Amyotrophic lateral sclerosis-associated mutant SOD1 inhibits anterograde axonal transport of mitochondria by reducing Miro1 levels. Moller A, Bauer CS, Cohen RN, Webster CP, De Vos KJ. Hum Mol Genet. 2017 Dec 1;26(23):4668-4679. doi: 10.1093/hmg/ddx348. PubMed
CRISPR-Cas9 mediated gene knockout in human coronary artery endothelial cells reveals a pro-inflammatory role of TLR2. Wang Y, Chen L, Tian Z, Shen X, Wang X, Wu H, Wang Y, Zou J, Liang J. Cell Biol Int. 2018 Feb;42(2):187-193. doi: 10.1002/cbin.10885. Epub 2017 Nov 9. PubMed
MCT1 and MCT4 Expression and Lactate Flux Activity Increase During White and Brown Adipogenesis and Impact Adipocyte Metabolism. Petersen C, Nielsen MD, Andersen ES, Basse AL, Isidor MS, Markussen LK, Viuff BM, Lambert IH, Hansen JB, Pedersen SF. Sci Rep. 2017 Oct 12;7(1):13101. doi: 10.1038/s41598-017-13298-z. PubMed
ANGPTL8 promotes the ability of ANGPTL3 to bind and inhibit lipoprotein lipase. Chi X, Britt EC, Shows HW, Hjelmaas AJ, Shetty SK, Cushing EM, Li W, Dou A, Zhang R, Davies BSJ. Mol Metab. 2017 Oct;6(10):1137-1149. doi: 10.1016/j.molmet.2017.06.014. Epub 2017 Jun 29. PubMed

Associated Plasmids

Toll-Like Receptor 8 Is a Major Sensor of Group B Streptococcus But Not Escherichia coli in Human Primary Monocytes and Macrophages. Ehrnstrom B, Beckwith KS, Yurchenko M, Moen SH, Kojen JF, Lentini G, Teti G, Damas JK, Espevik T, Stenvik J. Front Immunol. 2017 Oct 3;8:1243. doi: 10.3389/fimmu.2017.01243. eCollection 2017. PubMed
High-Throughput Functional Genetic and Compound Screens Identify Targets for Senescence Induction in Cancer. Wang L, Leite de Oliveira R, Wang C, Fernandes Neto JM, Mainardi S, Evers B, Lieftink C, Morris B, Jochems F, Willemsen L, Beijersbergen RL, Bernards R. Cell Rep. 2017 Oct 17;21(3):773-783. doi: 10.1016/j.celrep.2017.09.085. PubMed
MANF Promotes Differentiation and Migration of Neural Progenitor Cells with Potential Neural Regenerative Effects in Stroke. Tseng KY, Anttila JE, Khodosevich K, Tuominen RK, Lindahl M, Domanskyi A, Airavaara M. Mol Ther. 2018 Jan 3;26(1):238-255. doi: 10.1016/j.ymthe.2017.09.019. Epub 2017 Sep 21. PubMed
Intercellular mRNA trafficking via membrane nanotube-like extensions in mammalian cells. Haimovich G, Ecker CM, Dunagin MC, Eggan E, Raj A, Gerst JE, Singer RH. Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):E9873-E9882. doi: 10.1073/pnas.1706365114. Epub 2017 Oct 24. PubMed

Associated Plasmids

Class III phosphatidylinositol-3-OH kinase controls epithelial integrity through endosomal LKB1 regulation. O'Farrell F, Lobert VH, Sneeggen M, Jain A, Katheder NS, Wenzel EM, Schultz SW, Tan KW, Brech A, Stenmark H, Rusten TE. Nat Cell Biol. 2017 Dec;19(12):1412-1423. doi: 10.1038/ncb3631. Epub 2017 Oct 30. PubMed
StUbEx PLUS-A Modified Stable Tagged Ubiquitin Exchange System for Peptide Level Purification and In-Depth Mapping of Ubiquitination Sites. Akimov V, Olsen LCB, Hansen SVF, Barrio-Hernandez I, Puglia M, Jensen SS, Solov'yov IA, Kratchmarova I, Blagoev B. J Proteome Res. 2018 Jan 5;17(1):296-304. doi: 10.1021/acs.jproteome.7b00566. Epub 2017 Nov 1. PubMed
Nuclear TRIM25 Specifically Targets Influenza Virus Ribonucleoproteins to Block the Onset of RNA Chain Elongation. Meyerson NR, Zhou L, Guo YR, Zhao C, Tao YJ, Krug RM, Sawyer SL. Cell Host Microbe. 2017 Nov 8;22(5):627-638.e7. doi: 10.1016/j.chom.2017.10.003. Epub 2017 Nov 5. PubMed
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Promotion of Myoblast Differentiation by Fkbp5 via Cdk4 Isomerization. Ruiz-Estevez M, Staats J, Paatela E, Munson D, Katoku-Kikyo N, Yuan C, Asakura Y, Hostager R, Kobayashi H, Asakura A, Kikyo N. Cell Rep. 2018 Nov 27;25(9):2537-2551.e8. doi: 10.1016/j.celrep.2018.11.006. PubMed
Human Leukocyte Antigen Class I and II Knockout Human Induced Pluripotent Stem Cell-Derived Cells: Universal Donor for Cell Therapy. Mattapally S, Pawlik KM, Fast VG, Zumaquero E, Lund FE, Randall TD, Townes TM, Zhang J. J Am Heart Assoc. 2018 Dec 4;7(23):e010239. doi: 10.1161/JAHA.118.010239. PubMed
PUFA-Plasmalogens Attenuate the LPS-Induced Nitric Oxide Production by Inhibiting the NF-kB, p38 MAPK and JNK Pathways in Microglial Cells. Youssef M, Ibrahim A, Akashi K, Hossain MS. Neuroscience. 2019 Jan 15;397:18-30. doi: 10.1016/j.neuroscience.2018.11.030. Epub 2018 Nov 26. PubMed
Honey bee Royalactin unlocks conserved pluripotency pathway in mammals. Wan DC, Morgan SL, Spencley AL, Mariano N, Chang EY, Shankar G, Luo Y, Li TH, Huh D, Huynh SK, Garcia JM, Dovey CM, Lumb J, Liu L, Brown KV, Bermudez A, Luong R, Zeng H, Mascetti VL, Pitteri SJ, Wang J, Tu H, Quarta M, Sebastiano V, Nusse R, Rando TA, Carette JE, Bazan JF, Wang KC. Nat Commun. 2018 Dec 4;9(1):5078. doi: 10.1038/s41467-018-06256-4. PubMed
Whole genome variant association across 100 dogs identifies a frame shift mutation in DISHEVELLED 2 which contributes to Robinow-like syndrome in Bulldogs and related screw tail dog breeds. Mansour TA, Lucot K, Konopelski SE, Dickinson PJ, Sturges BK, Vernau KL, Choi S, Stern JA, Thomasy SM, Doring S, Verstraete FJM, Johnson EG, York D, Rebhun RB, Ho HH, Brown CT, Bannasch DL. PLoS Genet. 2018 Dec 6;14(12):e1007850. doi: 10.1371/journal.pgen.1007850. eCollection 2018 Dec. PubMed
Unveiling the Role of the Most Impactful Cardiovascular Risk Locus through Haplotype Editing. Lo Sardo V, Chubukov P, Ferguson W, Kumar A, Teng EL, Duran M, Zhang L, Cost G, Engler AJ, Urnov F, Topol EJ, Torkamani A, Baldwin KK. Cell. 2018 Dec 13;175(7):1796-1810.e20. doi: 10.1016/j.cell.2018.11.014. Epub 2018 Dec 6. PubMed
Cancer Suicide Gene Therapy with TK.007. Hossain JA, Riecken K, Miletic H, Fehse B. Methods Mol Biol. 2019;1895:11-26. doi: 10.1007/978-1-4939-8922-5_2. PubMed
Disruption of protein neddylation with MLN4924 attenuates paclitaxel-induced apoptosis and microtubule polymerization in ovarian cancer cells. Hong X, Li S, Li W, Xie M, Wei Z, Guo H, Wei W, Zhang S. Biochem Biophys Res Commun. 2019 Jan 15;508(3):986-990. doi: 10.1016/j.bbrc.2018.12.048. Epub 2018 Dec 11. PubMed
The histone chaperone complex FACT promotes proliferative switch of G0 cancer cells. Bi L, Xie C, Yao M, Thae Hnit SS, Vignarajan S, Wang Y, Wang Q, Xi Z, Xu H, Li Z, de Souza P, Tee A, Wong M, Liu T, Zhao X, Zhou J, Xu L, Dong Q. Int J Cancer. 2018 Dec 13. doi: 10.1002/ijc.32065. PubMed
Toll-like receptor chaperone HSP90B1 and the immune response to Mycobacteria. Graustein AD, Misch EA, Musvosvi M, Shey M, Shah JA, Seshadri C, Aguoju A, Bowman K, Mulenga H, Veldsman A, Hanekom WA, Hatherill M, Scriba TJ, Hawn TR. PLoS One. 2018 Dec 14;13(12):e0208940. doi: 10.1371/journal.pone.0208940. eCollection 2018. PubMed
An amphipathic helix of vinexin alpha is necessary for a substrate stiffness-dependent conformational change in vinculin. Hino N, Ichikawa T, Kimura Y, Matsuda M, Ueda K, Kioka N. J Cell Sci. 2019 Jan 21;132(2). pii: jcs.217349. doi: 10.1242/jcs.217349. PubMed
Genome-wide CRISPR Analysis Identifies Substrate-Specific Conjugation Modules in ER-Associated Degradation. Leto DE, Morgens DW, Zhang L, Walczak CP, Elias JE, Bassik MC, Kopito RR. Mol Cell. 2019 Jan 17;73(2):377-389.e11. doi: 10.1016/j.molcel.2018.11.015. Epub 2018 Dec 20. PubMed
Identification of Novel Protein Targets of Dimethyl Fumarate Modification in Neurons and Astrocytes Reveals Actions Independent of Nrf2 Stabilization. Piroli GG, Manuel AM, Patel T, Walla MD, Shi L, Lanci SA, Wang J, Galloway A, Ortinski PI, Smith DS, Frizzell N. Mol Cell Proteomics. 2019 Mar;18(3):504-519. doi: 10.1074/mcp.RA118.000922. Epub 2018 Dec 26. PubMed
Proteolytic cleavage of Beclin 1 exacerbates neurodegeneration. Bieri G, Lucin KM, O'Brien CE, Zhang H, Villeda SA, Wyss-Coray T. Mol Neurodegener. 2018 Dec 29;13(1):68. doi: 10.1186/s13024-018-0302-4. PubMed
Common ELF1 deletion in prostate cancer bolsters oncogenic ETS function, inhibits senescence and promotes docetaxel resistance. Budka JA, Ferris MW, Capone MJ, Hollenhorst PC. Genes Cancer. 2018 May;9(5-6):198-214. doi: 10.18632/genesandcancer.182. PubMed
CD46 Null Packaging Cell Line Improves Measles Lentiviral Vector Production and Gene Delivery to Hematopoietic Stem and Progenitor Cells. Ozog S, Chen CX, Simpson E, Garijo O, Timberlake ND, Minder P, Verhoeyen E, Torbett BE. Mol Ther Methods Clin Dev. 2018 Nov 24;13:27-39. doi: 10.1016/j.omtm.2018.11.006. eCollection 2019 Jun 14. PubMed
UBQLN4 Represses Homologous Recombination and Is Overexpressed in Aggressive Tumors. Jachimowicz RD, Beleggia F, Isensee J, Velpula BB, Goergens J, Bustos MA, Doll MA, Shenoy A, Checa-Rodriguez C, Wiederstein JL, Baranes-Bachar K, Bartenhagen C, Hertwig F, Teper N, Nishi T, Schmitt A, Distelmaier F, Ludecke HJ, Albrecht B, Kruger M, Schumacher B, Geiger T, Hoon DSB, Huertas P, Fischer M, Hucho T, Peifer M, Ziv Y, Reinhardt HC, Wieczorek D, Shiloh Y. Cell. 2019 Jan 24;176(3):505-519.e22. doi: 10.1016/j.cell.2018.11.024. Epub 2019 Jan 3. PubMed
An efficient method for the transduction of primary pediatric glioma neurospheres. Meel MH, Metselaar DS, Waranecki P, Kaspers GJL, Hulleman E. MethodsX. 2018 Feb 27;5:173-183. doi: 10.1016/j.mex.2018.02.006. eCollection 2018. PubMed
Development of a Novel Anti-CD19 Chimeric Antigen Receptor: A Paradigm for an Affordable CAR T Cell Production at Academic Institutions. Castella M, Boronat A, Martin-Ibanez R, Rodriguez V, Sune G, Caballero M, Marzal B, Perez-Amill L, Martin-Antonio B, Castano J, Bueno C, Balague O, Gonzalez-Navarro EA, Serra-Pages C, Engel P, Vilella R, Benitez-Ribas D, Ortiz-Maldonado V, Cid J, Tabera J, Canals JM, Lozano M, Baumann T, Vilarrodona A, Trias E, Campo E, Menendez P, Urbano-Ispizua A, Yague J, Perez-Galan P, Rives S, Delgado J, Juan M. Mol Ther Methods Clin Dev. 2018 Dec 6;12:134-144. doi: 10.1016/j.omtm.2018.11.010. eCollection 2019 Mar 15. PubMed
USP15 Participates in Hepatitis C Virus Propagation through Regulation of Viral RNA Translation and Lipid Droplet Formation. Kusakabe S, Suzuki T, Sugiyama Y, Haga S, Horike K, Tokunaga M, Hirano J, Zhang H, Chen DV, Ishiga H, Komoda Y, Ono C, Fukuhara T, Yamamoto M, Ikawa M, Satoh T, Akira S, Tanaka T, Moriishi K, Fukai M, Taketomi A, Yoshio S, Kanto T, Suzuki T, Okamoto T, Matsuura Y. J Virol. 2019 Mar 5;93(6). pii: JVI.01708-18. doi: 10.1128/JVI.01708-18. Print 2019 Mar 15. PubMed
Genome-wide analysis of ETV1 targets: Insights into the role of ETV1 in tumor progression. Eid W, Abdel-Rehim W. J Cell Biochem. 2019 Jan 10. doi: 10.1002/jcb.28169. PubMed
Egr2 overexpression in Schwann cells increases myelination frequency in vitro. Tammia M, Mi R, Sluch VM, Zhu A, Chung T, Shinn D, Zack DJ, Hoke A, Mao HQ. Heliyon. 2018 Nov 29;4(11):e00982. doi: 10.1016/j.heliyon.2018.e00982. eCollection 2018 Nov. PubMed
SIRT3 promotes antimycobacterial defenses by coordinating mitochondrial and autophagic functions. Kim TS, Jin YB, Kim YS, Kim S, Kim JK, Lee HM, Suh HW, Choe JH, Kim YJ, Koo BS, Kim HN, Jung M, Lee SH, Kim DK, Chung C, Son JW, Min JJ, Kim JM, Deng CX, Kim HS, Lee SR, Jo EK. Autophagy. 2019 Aug;15(8):1356-1375. doi: 10.1080/15548627.2019.1582743. Epub 2019 Mar 4. PubMed
Teneurin C-Terminal Associated Peptide (TCAP)-1 and Latrophilin Interaction in HEK293 Cells: Evidence for Modulation of Intercellular Adhesion. Husic M, Barsyte-Lovejoy D, Lovejoy DA. Front Endocrinol (Lausanne). 2019 Feb 1;10:22. doi: 10.3389/fendo.2019.00022. eCollection 2019. PubMed
PRMT5 Modulates Splicing for Genome Integrity and Preserves Proteostasis of Hematopoietic Stem Cells. Tan DQ, Li Y, Yang C, Li J, Tan SH, Chin DWL, Nakamura-Ishizu A, Yang H, Suda T. Cell Rep. 2019 Feb 26;26(9):2316-2328.e6. doi: 10.1016/j.celrep.2019.02.001. PubMed
Single-Cell RNA-Seq Reveals AML Hierarchies Relevant to Disease Progression and Immunity. van Galen P, Hovestadt V, Wadsworth Ii MH, Hughes TK, Griffin GK, Battaglia S, Verga JA, Stephansky J, Pastika TJ, Lombardi Story J, Pinkus GS, Pozdnyakova O, Galinsky I, Stone RM, Graubert TA, Shalek AK, Aster JC, Lane AA, Bernstein BE. Cell. 2019 Mar 7;176(6):1265-1281.e24. doi: 10.1016/j.cell.2019.01.031. Epub 2019 Feb 28. PubMed
Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR. Rankin CR, Treger J, Faure-Kumar E, Benhammou J, Anisman-Posner D, Bollinger AE, Pothoulakis C, Padua DM. J Vis Exp. 2019 Mar 1;(145). doi: 10.3791/59233. PubMed
The TLR4 adaptor TRAM controls the phagocytosis of Gram-negative bacteria by interacting with the Rab11-family interacting protein 2. Skjesol A, Yurchenko M, Bosl K, Gravastrand C, Nilsen KE, Grovdal LM, Agliano F, Patane F, Lentini G, Kim H, Teti G, Kumar Sharma A, Kandasamy RK, Sporsheim B, Starheim KK, Golenbock DT, Stenmark H, McCaffrey M, Espevik T, Husebye H. PLoS Pathog. 2019 Mar 18;15(3):e1007684. doi: 10.1371/journal.ppat.1007684. eCollection 2019 Mar. PubMed
miR-338-3p regulates the proliferation, apoptosis and migration of SW480 cells by targeting MACC1. Lu M, Huang H, Yang J, Li J, Zhao G, Li W, Li X, Liu G, Wei L, Shi B, Zhao C, Fu Y. Exp Ther Med. 2019 Apr;17(4):2807-2814. doi: 10.3892/etm.2019.7260. Epub 2019 Feb 12. PubMed
Production and Validation of Lentiviral Vectors for CRISPR/Cas9 Delivery. Ryo LB, Thomsen EA, Mikkelsen JG. Methods Mol Biol. 2019;1961:93-109. doi: 10.1007/978-1-4939-9170-9_7. PubMed
The kinase PERK and the transcription factor ATF4 play distinct and essential roles in autophagy resulting from tunicamycin-induced ER stress. Luhr M, Torgersen ML, Szalai P, Hashim A, Brech A, Staerk J, Engedal N. J Biol Chem. 2019 May 17;294(20):8197-8217. doi: 10.1074/jbc.RA118.002829. Epub 2019 Mar 29. PubMed
A Multiscale Map of the Stem Cell State in Pancreatic Adenocarcinoma. Lytle NK, Ferguson LP, Rajbhandari N, Gilroy K, Fox RG, Deshpande A, Schurch CM, Hamilton M, Robertson N, Lin W, Noel P, Wartenberg M, Zlobec I, Eichmann M, Galvan JA, Karamitopoulou E, Gilderman T, Esparza LA, Shima Y, Spahn P, French R, Lewis NE, Fisch KM, Sasik R, Rosenthal SB, Kritzik M, Von Hoff D, Han H, Ideker T, Deshpande AJ, Lowy AM, Adams PD, Reya T. Cell. 2019 Apr 18;177(3):572-586.e22. doi: 10.1016/j.cell.2019.03.010. Epub 2019 Apr 4. PubMed
Bok regulates mitochondrial fusion and morphology. Schulman JJ, Szczesniak LM, Bunker EN, Nelson HA, Roe MW, Wagner LE 2nd, Yule DI, Wojcikiewicz RJH. Cell Death Differ. 2019 Dec;26(12):2682-2694. doi: 10.1038/s41418-019-0327-4. Epub 2019 Apr 11. PubMed
Development of a Synthetic 3-ketosteroid Delta(1)-dehydrogenase for the Generation of a Novel Catabolic Pathway Enabling Cholesterol Degradation in Human Cells. D'Arcy BM, Swingle MR, Schambeau L, Pannell L, Prakash A, Honkanen RE. Sci Rep. 2019 Apr 12;9(1):5969. doi: 10.1038/s41598-019-42046-8. PubMed
Lentiviral Vector Platform for the Efficient Delivery of Epigenome-editing Tools into Human Induced Pluripotent Stem Cell-derived Disease Models. Tagliafierro L, Ilich E, Moncalvo M, Gu J, Sriskanda A, Grenier C, Murphy SK, Chiba-Falek O, Kantor B. J Vis Exp. 2019 Mar 29;(145). doi: 10.3791/59241. PubMed
Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia. Huang Y, Su R, Sheng Y, Dong L, Dong Z, Xu H, Ni T, Zhang ZS, Zhang T, Li C, Han L, Zhu Z, Lian F, Wei J, Deng Q, Wang Y, Wunderlich M, Gao Z, Pan G, Zhong D, Zhou H, Zhang N, Gan J, Jiang H, Mulloy JC, Qian Z, Chen J, Yang CG. Cancer Cell. 2019 Apr 15;35(4):677-691.e10. doi: 10.1016/j.ccell.2019.03.006. PubMed
TNF-alpha/IL-1beta-licensed mesenchymal stromal cells promote corneal allograft survival via myeloid cell-mediated induction of Foxp3(+) regulatory T cells in the lung. Murphy N, Treacy O, Lynch K, Morcos M, Lohan P, Howard L, Fahy G, Griffin MD, Ryan AE, Ritter T. FASEB J. 2019 Aug;33(8):9404-9421. doi: 10.1096/fj.201900047R. Epub 2019 May 20. PubMed
RB1 Deletion in Retinoblastoma Protein Pathway-Disrupted Cells Results in DNA Damage and Cancer Progression. Marshall AE, Roes MV, Passos DT, DeWeerd MC, Chaikovsky AC, Sage J, Howlett CJ, Dick FA. Mol Cell Biol. 2019 Jul 29;39(16). pii: MCB.00105-19. doi: 10.1128/MCB.00105-19. Print 2019 Aug 15. PubMed
TRIM5alpha Restricts Flavivirus Replication by Targeting the Viral Protease for Proteasomal Degradation. Chiramel AI, Meyerson NR, McNally KL, Broeckel RM, Montoya VR, Mendez-Solis O, Robertson SJ, Sturdevant GL, Lubick KJ, Nair V, Youseff BH, Ireland RM, Bosio CM, Kim K, Luban J, Hirsch VM, Taylor RT, Bouamr F, Sawyer SL, Best SM. Cell Rep. 2019 Jun 11;27(11):3269-3283.e6. doi: 10.1016/j.celrep.2019.05.040. PubMed
WDFY2 restrains matrix metalloproteinase secretion and cell invasion by controlling VAMP3-dependent recycling. Sneeggen M, Pedersen NM, Campsteijn C, Haugsten EM, Stenmark H, Schink KO. Nat Commun. 2019 Jun 28;10(1):2850. doi: 10.1038/s41467-019-10794-w. PubMed

Associated Plasmids

Adenovirus oncoprotein E4orf6 triggers Cullin5 neddylation to activate the CLR5 E3 ligase for p53 degradation. Guo H, Shen S, Li Y, Bi R, Zhang N, Zheng W, Deng Y, Yang Y, Yu XF, Wang C, Wei W. Biochem Biophys Res Commun. 2019 Sep 3;516(4):1242-1247. doi: 10.1016/j.bbrc.2019.07.028. Epub 2019 Jul 10. PubMed
Activation of the autophagy pathway by Torovirus infection is irrelevant for virus replication. Avila-Perez G, Diaz-Beneitez E, Cubas-Gaona LL, Nieves-Molina G, Rodriguez JR, Rodriguez JF, Rodriguez D. PLoS One. 2019 Jul 15;14(7):e0219428. doi: 10.1371/journal.pone.0219428. eCollection 2019. PubMed
A Chemical Screen Identifies Compounds Capable of Selecting for Haploidy in Mammalian Cells. Olbrich T, Vega-Sendino M, Murga M, de Carcer G, Malumbres M, Ortega S, Ruiz S, Fernandez-Capetillo O. Cell Rep. 2019 Jul 16;28(3):597-604.e4. doi: 10.1016/j.celrep.2019.06.060. PubMed
P11 Loss-of-Function is Associated with Decreased Cell Proliferation and Neurobehavioral Disorders in Mice. Liu G, Wang Y, Zheng W, Cheng H, Zhou R. Int J Biol Sci. 2019 May 20;15(7):1383-1395. doi: 10.7150/ijbs.33773. eCollection 2019. PubMed
Regulatory mechanisms for the axonal localization of tau protein in neurons. Iwata M, Watanabe S, Yamane A, Miyasaka T, Misonou H. Mol Biol Cell. 2019 Sep 1;30(19):2441-2457. doi: 10.1091/mbc.E19-03-0183. Epub 2019 Aug 7. PubMed
ESCRT-mediated phagophore sealing during mitophagy. Zhen Y, Spangenberg H, Munson MJ, Brech A, Schink KO, Tan KW, Sorensen V, Wenzel EM, Radulovic M, Engedal N, Simonsen A, Raiborg C, Stenmark H. Autophagy. 2019 Aug 1:1-16. doi: 10.1080/15548627.2019.1639301. PubMed
A molecular triage process mediated by RING finger protein 126 and BCL2-associated athanogene 6 regulates degradation of G0/G1 switch gene 2. Kamikubo K, Kato H, Kioka H, Yamazaki S, Tsukamoto O, Nishida Y, Asano Y, Imamura H, Kawahara H, Shintani Y, Takashima S. J Biol Chem. 2019 Oct 4;294(40):14562-14573. doi: 10.1074/jbc.RA119.008544. Epub 2019 Aug 1. PubMed
Innate Immune Response to Influenza Virus at Single-Cell Resolution in Human Epithelial Cells Revealed Paracrine Induction of Interferon Lambda 1. Ramos I, Smith G, Ruf-Zamojski F, Martinez-Romero C, Fribourg M, Carbajal EA, Hartmann BM, Nair VD, Marjanovic N, Monteagudo PL, DeJesus VA, Mutetwa T, Zamojski M, Tan GS, Jayaprakash C, Zaslavsky E, Albrecht RA, Sealfon SC, Garcia-Sastre A, Fernandez-Sesma A. J Virol. 2019 Sep 30;93(20). pii: JVI.00559-19. doi: 10.1128/JVI.00559-19. Print 2019 Oct 15. PubMed
The Hippo pathway modulates resistance to BET proteins inhibitors in lung cancer cells. Gobbi G, Donati B, Do Valle IF, Reggiani F, Torricelli F, Remondini D, Castellani G, Ambrosetti DC, Ciarrocchi A, Sancisi V. Oncogene. 2019 Oct;38(42):6801-6817. doi: 10.1038/s41388-019-0924-1. Epub 2019 Aug 12. PubMed
Visualization of Single mRNAs in Live Neurons. Shim JY, Lee BH, Park HY. Methods Mol Biol. 2019;2038:47-61. doi: 10.1007/978-1-4939-9674-2_4. PubMed
A CEP104-CSPP1 Complex Is Required for Formation of Primary Cilia Competent in Hedgehog Signaling. Frikstad KM, Molinari E, Thoresen M, Ramsbottom SA, Hughes F, Letteboer SJF, Gilani S, Schink KO, Stokke T, Geimer S, Pedersen LB, Giles RH, Akhmanova A, Roepman R, Sayer JA, Patzke S. Cell Rep. 2019 Aug 13;28(7):1907-1922.e6. doi: 10.1016/j.celrep.2019.07.025. PubMed
Identification of an ATP-sensitive potassium channel in mitochondria. Paggio A, Checchetto V, Campo A, Menabo R, Di Marco G, Di Lisa F, Szabo I, Rizzuto R, De Stefani D. Nature. 2019 Aug;572(7771):609-613. doi: 10.1038/s41586-019-1498-3. Epub 2019 Aug 21. PubMed
A Tag-Based Affinity Purification Mass Spectrometry Workflow for Systematic Isolation of the Human Mitochondrial Protein Complexes. Wu Z, Malty R, Moutaoufik MT, Zhang Q, Jessulat M, Babu M. Adv Exp Med Biol. 2019;1158:83-100. doi: 10.1007/978-981-13-8367-0_6. PubMed
MicroRNA-138 is a Prognostic Biomarker for Triple-Negative Breast Cancer and Promotes Tumorigenesis via TUSC2 repression. Nama S, Muhuri M, Di Pascale F, Quah S, Aswad L, Fullwood M, Sampath P. Sci Rep. 2019 Sep 3;9(1):12718. doi: 10.1038/s41598-019-49155-4. PubMed
B7-H3 as a Novel CAR-T Therapeutic Target for Glioblastoma. Tang X, Zhao S, Zhang Y, Wang Y, Zhang Z, Yang M, Zhu Y, Zhang G, Guo G, Tong A, Zhou L. Mol Ther Oncolytics. 2019 Jul 23;14:279-287. doi: 10.1016/j.omto.2019.07.002. eCollection 2019 Sep 27. PubMed
A second open reading frame in human enterovirus determines viral replication in intestinal epithelial cells. Guo H, Li Y, Liu G, Jiang Y, Shen S, Bi R, Huang H, Cheng T, Wang C, Wei W. Nat Commun. 2019 Sep 6;10(1):4066. doi: 10.1038/s41467-019-12040-9. PubMed
SLC1A3 contributes to L-asparaginase resistance in solid tumors. Sun J, Nagel R, Zaal EA, Ugalde AP, Han R, Proost N, Song JY, Pataskar A, Burylo A, Fu H, Poelarends GJ, van de Ven M, van Tellingen O, Berkers CR, Agami R. EMBO J. 2019 Oct 4;38(21):e102147. doi: 10.15252/embj.2019102147. Epub 2019 Sep 16. PubMed
Improved GaLV-TR Glycoproteins to Pseudotype Lentiviral Vectors: Impact of Viral Protease Activity in the Production of LV Pseudotypes. Tomas HA, Mestre DA, Rodrigues AF, Guerreiro MR, Carrondo MJT, Coroadinha AS. Mol Ther Methods Clin Dev. 2019 Aug 14;15:1-8. doi: 10.1016/j.omtm.2019.08.001. eCollection 2019 Dec 13. PubMed
CGGBP1 regulates CTCF occupancy at repeats. Patel D, Patel M, Datta S, Singh U. Epigenetics Chromatin. 2019 Sep 23;12(1):57. doi: 10.1186/s13072-019-0305-6. PubMed
Dynamic Incorporation of Histone H3 Variants into Chromatin Is Essential for Acquisition of Aggressive Traits and Metastatic Colonization. Gomes AP, Ilter D, Low V, Rosenzweig A, Shen ZJ, Schild T, Rivas MA, Er EE, McNally DR, Mutvei AP, Han J, Ou YH, Cavaliere P, Mullarky E, Nagiec M, Shin S, Yoon SO, Dephoure N, Massague J, Melnick AM, Cantley LC, Tyler JK, Blenis J. Cancer Cell. 2019 Oct 14;36(4):402-417.e13. doi: 10.1016/j.ccell.2019.08.006. Epub 2019 Sep 26. PubMed
Epigenetic Suppression of Interferon Lambda Receptor Expression Leads to Enhanced Human Norovirus Replication In Vitro. Arthur SE, Sorgeloos F, Hosmillo M, Goodfellow IG. mBio. 2019 Oct 1;10(5). pii: mBio.02155-19. doi: 10.1128/mBio.02155-19. PubMed
Neuromodulator Signaling Bidirectionally Controls Vesicle Numbers in Human Synapses. Patzke C, Brockmann MM, Dai J, Gan KJ, Grauel MK, Fenske P, Liu Y, Acuna C, Rosenmund C, Sudhof TC. Cell. 2019 Oct 3;179(2):498-513.e22. doi: 10.1016/j.cell.2019.09.011. PubMed
TIMP3 expression associates with prognosis in colorectal cancer and its novel arylsulfonamide inducer, MPT0B390, inhibits tumor growth, metastasis and angiogenesis. Huang HL, Liu YM, Sung TY, Huang TC, Cheng YW, Liou JP, Pan SL. Theranostics. 2019 Sep 18;9(22):6676-6689. doi: 10.7150/thno.34020. eCollection 2019. PubMed
Individual cristae within the same mitochondrion display different membrane potentials and are functionally independent. Wolf DM, Segawa M, Kondadi AK, Anand R, Bailey ST, Reichert AS, van der Bliek AM, Shackelford DB, Liesa M, Shirihai OS. EMBO J. 2019 Nov 15;38(22):e101056. doi: 10.15252/embj.2018101056. Epub 2019 Oct 14. PubMed
MYC predetermines the sensitivity of gastrointestinal cancer to antifolate drugs through regulating TYMS transcription. Liu T, Han Y, Yu C, Ji Y, Wang C, Chen X, Wang X, Shen J, Zhang Y, Lang JY. EBioMedicine. 2019 Oct;48:289-300. doi: 10.1016/j.ebiom.2019.10.003. Epub 2019 Oct 21. PubMed
A centrosome-localized calcium signal is essential for mammalian cell mitosis. Helassa N, Nugues C, Rajamanoharan D, Burgoyne RD, Haynes LP. FASEB J. 2019 Dec;33(12):14602-14610. doi: 10.1096/fj.201901662R. Epub 2019 Nov 2. PubMed
Tumour exosomal CEMIP protein promotes cancer cell colonization in brain metastasis. Rodrigues G, Hoshino A, Kenific CM, Matei IR, Steiner L, Freitas D, Kim HS, Oxley PR, Scandariato I, Casanova-Salas I, Dai J, Badwe CR, Gril B, Tesic Mark M, Dill BD, Molina H, Zhang H, Benito-Martin A, Bojmar L, Ararso Y, Offer K, LaPlant Q, Buehring W, Wang H, Jiang X, Lu TM, Liu Y, Sabari JK, Shin SJ, Narula N, Ginter PS, Rajasekhar VK, Healey JH, Meylan E, Costa-Silva B, Wang SE, Rafii S, Altorki NK, Rudin CM, Jones DR, Steeg PS, Peinado H, Ghajar CM, Bromberg J, de Sousa M, Pisapia D, Lyden D. Nat Cell Biol. 2019 Nov;21(11):1403-1412. doi: 10.1038/s41556-019-0404-4. Epub 2019 Nov 4. PubMed
LCP1 triggers mTORC2/AKT activity and is pharmacologically targeted by enzastaurin in hypereosinophilia. Ma G, Gezer D, Herrmann O, Feldberg K, Schemionek M, Jawhar M, Reiter A, Brummendorf TH, Koschmieder S, Chatain N. Mol Carcinog. 2020 Jan;59(1):87-103. doi: 10.1002/mc.23131. Epub 2019 Nov 6. PubMed
Epigenetic regulation of microglial phosphatidylinositol 3-kinase pathway involved in long-term potentiation and synaptic plasticity in rats. Saw G, Krishna K, Gupta N, Soong TW, Mallilankaraman K, Sajikumar S, Dheen ST. Glia. 2020 Mar;68(3):656-669. doi: 10.1002/glia.23748. Epub 2019 Nov 8. PubMed
Injectable, Hyaluronic Acid-Based Scaffolds with Macroporous Architecture for Gene Delivery. Ehsanipour A, Nguyen T, Aboufadel T, Sathialingam M, Cox P, Xiao W, Walthers CM, Seidlits SK. Cell Mol Bioeng. 2019 Sep 4;12(5):399-413. doi: 10.1007/s12195-019-00593-0. eCollection 2019 Oct. PubMed
Hepatitis Delta Virus Alters the Autophagy Process To Promote Its Genome Replication. Khabir M, Aliche AZ, Sureau C, Blanchet M, Labonte P. J Virol. 2020 Jan 31;94(4). pii: JVI.01936-19. doi: 10.1128/JVI.01936-19. Print 2020 Jan 31. PubMed
Ubiquitination of the HPV Oncoprotein E6 Is Critical for E6/E6AP-Mediated p53 Degradation. Li S, Hong X, Wei Z, Xie M, Li W, Liu G, Guo H, Yang J, Wei W, Zhang S. Front Microbiol. 2019 Oct 31;10:2483. doi: 10.3389/fmicb.2019.02483. eCollection 2019. PubMed
Identification of Novel Adenylyl Cyclase 5 (AC5) Signaling Networks in D1 and D2 Medium Spiny Neurons using Bimolecular Fluorescence Complementation Screening. Doyle TB, Muntean BS, Ejendal KF, Hayes MP, Soto-Velasquez M, Martemyanov KA, Dessauer CW, Hu CD, Watts VJ. Cells. 2019 Nov 19;8(11). pii: cells8111468. doi: 10.3390/cells8111468. PubMed
A generic cell surface ligand system for studying cell-cell recognition. Denham EM, Barton MI, Black SM, Bridge MJ, de Wet B, Paterson RL, van der Merwe PA, Goyette J. PLoS Biol. 2019 Dec 9;17(12):e3000549. doi: 10.1371/journal.pbio.3000549. eCollection 2019 Dec. PubMed
FABP5 coordinates lipid signaling that promotes prostate cancer metastasis. Carbonetti G, Wilpshaar T, Kroonen J, Studholme K, Converso C, d'Oelsnitz S, Kaczocha M. Sci Rep. 2019 Dec 12;9(1):18944. doi: 10.1038/s41598-019-55418-x. PubMed
TULIP2: An Improved Method for the Identification of Ubiquitin E3-Specific Targets. Salas-Lloret D, Agabitini G, Gonzalez-Prieto R. Front Chem. 2019 Nov 26;7:802. doi: 10.3389/fchem.2019.00802. eCollection 2019. PubMed
Efficient Modulation of TP53 Expression in Human Induced Pluripotent Stem Cells. Uhlmann C, Kuhn LM, Tigges J, Fritsche E, Kahlert UD. Curr Protoc Stem Cell Biol. 2020 Mar;52(1):e102. doi: 10.1002/cpsc.102. PubMed
Fumarate and oxidative stress synergize to promote stability of C/EBP homologous protein in the adipocyte. Manuel AM, Walla MD, Dorn MT, Tanis RM, Piroli GG, Frizzell N. Free Radic Biol Med. 2020 Feb 20;148:70-82. doi: 10.1016/j.freeradbiomed.2019.12.037. Epub 2019 Dec 26. PubMed
Genome-wide CRISPR-Cas9 screening reveals ubiquitous T cell cancer targeting via the monomorphic MHC class I-related protein MR1. Crowther MD, Dolton G, Legut M, Caillaud ME, Lloyd A, Attaf M, Galloway SAE, Rius C, Farrell CP, Szomolay B, Ager A, Parker AL, Fuller A, Donia M, McCluskey J, Rossjohn J, Svane IM, Phillips JD, Sewell AK. Nat Immunol. 2020 Feb;21(2):178-185. doi: 10.1038/s41590-019-0578-8. Epub 2020 Jan 20. PubMed
Reprogramming Fibroblasts to Neural Stem Cells by Overexpression of the Transcription Factor Ptf1a. Jin K, Zou M, Xiao D, Xiang M. Methods Mol Biol. 2020;2117:245-263. doi: 10.1007/978-1-0716-0301-7_15. PubMed
PPM1A Controls Diabetic Gene Programming through Directly Dephosphorylating PPARgamma at Ser273. Khim KW, Choi SS, Jang HJ, Lee YH, Lee E, Hyun JM, Eom HJ, Yoon S, Choi JW, Park TE, Nam D, Choi JH. Cells. 2020 Feb 2;9(2). pii: cells9020343. doi: 10.3390/cells9020343. PubMed
Belinostat resolves skin barrier defects in atopic dermatitis by targeting the dysregulated miR-335:SOX6 axis. Liew WC, Sundaram GM, Quah S, Lum GG, Tan JSL, Ramalingam R, Common JEA, Tang MBY, Lane EB, Thng STG, Sampath P. J Allergy Clin Immunol. 2020 Feb 21. pii: S0091-6749(20)30259-1. doi: 10.1016/j.jaci.2020.02.007. PubMed
Proteasomal inhibition triggers viral oncoprotein degradation via autophagy-lysosomal pathway. Gain C, Malik S, Bhattacharjee S, Ghosh A, Robertson ES, Das BB, Saha A. PLoS Pathog. 2020 Feb 24;16(2):e1008105. doi: 10.1371/journal.ppat.1008105. eCollection 2020 Feb. PubMed
Functional angiogenesis requires microenvironmental cues balancing endothelial cell migration and proliferation. Wang WY, Lin D, Jarman EH, Polacheck WJ, Baker BM. Lab Chip. 2020 Mar 17;20(6):1153-1166. doi: 10.1039/c9lc01170f. PubMed
Accurate and live peroxisome biogenesis evaluation achieved by lentiviral expression of a green fluorescent protein fused to a peroxisome targeting signal 1. Demaret T, Courtoy GE, Ravau J, Van Der Smissen P, Najimi M, Sokal EM. Histochem Cell Biol. 2020 Mar 2. pii: 10.1007/s00418-020-01855-z. doi: 10.1007/s00418-020-01855-z. PubMed

Associated Plasmids

Therapeutic potential of KLF2-induced exosomal microRNAs in pulmonary hypertension. Sindi HA, Russomanno G, Satta S, Abdul-Salam VB, Jo KB, Qazi-Chaudhry B, Ainscough AJ, Szulcek R, Jan Bogaard H, Morgan CC, Pullamsetti SS, Alzaydi MM, Rhodes CJ, Piva R, Eichstaedt CA, Grunig E, Wilkins MR, Wojciak-Stothard B. Nat Commun. 2020 Mar 4;11(1):1185. doi: 10.1038/s41467-020-14966-x. PubMed
The Peroxisome Proliferator-Activated Receptor alpha- Agonist Gemfibrozil Promotes Defense Against Mycobacterium abscessus Infections. Kim YS, Kim JK, Hanh BTB, Kim SY, Kim HJ, Kim YJ, Jeon SM, Park CR, Oh GT, Park JW, Kim JM, Jang J, Jo EK. Cells. 2020 Mar 6;9(3). pii: cells9030648. doi: 10.3390/cells9030648. PubMed
An MXD1-derived repressor peptide identifies noncoding mediators of MYC-driven cell proliferation. Raffeiner P, Hart JR, Garcia-Caballero D, Bar-Peled L, Weinberg MS, Vogt PK. Proc Natl Acad Sci U S A. 2020 Mar 24;117(12):6571-6579. doi: 10.1073/pnas.1921786117. Epub 2020 Mar 10. PubMed
Optogenetic control of perforant pathway kindled seizures by photoinhibition of CA3 after insertion of Jaws into CA3 neuronal cells. Farzaneh M, Sayyah M, Mirzapourdelavar H, Gholami Pourbadie H, Zibaii MI, Latifi H. Exp Neurol. 2020 Jun;328:113280. doi: 10.1016/j.expneurol.2020.113280. Epub 2020 Mar 9. PubMed
Genetic Manipulation of Human Intestinal Enteroids Demonstrates the Necessity of a Functional Fucosyltransferase 2 Gene for Secretor-Dependent Human Norovirus Infection. Haga K, Ettayebi K, Tenge VR, Karandikar UC, Lewis MA, Lin SC, Neill FH, Ayyar BV, Zeng XL, Larson G, Ramani S, Atmar RL, Estes MK. mBio. 2020 Mar 17;11(2). pii: mBio.00251-20. doi: 10.1128/mBio.00251-20. PubMed
Histone H1 eviction by the histone chaperone SET reduces cell survival following DNA damage. Mandemaker IK, Zhou D, Bruens ST, Dekkers DH, Verschure PJ, Edupuganti RR, Meshorer E, Demmers JAA, Marteijn JA. J Cell Sci. 2020 May 11;133(9). pii: jcs.235473. doi: 10.1242/jcs.235473. PubMed
Structure-Based Design and Discovery of a Long-Acting Cocaine Hydrolase Mutant with Improved Binding Affinity to Neonatal Fc Receptor for Treatment of Cocaine Abuse. Zheng F, Chen X, Kim K, Zhang T, Huang H, Zhou S, Zhang J, Jin Z, Zhan CG. AAPS J. 2020 Mar 18;22(3):62. doi: 10.1208/s12248-020-00442-3. PubMed
Protein Kinase C-eta Deficiency Does Not Impair Antiviral Immunity and CD8(+) T Cell Activation. Liu HY, Pedros C, Kong KF, Canonigo-Balancio AJ, Altman A. J Immunol. 2020 May 1;204(9):2439-2446. doi: 10.4049/jimmunol.1900963. Epub 2020 Mar 20. PubMed
Rosuvastatin Enhances VSV-G Lentiviral Transduction of NK Cells via Upregulation of the Low-Density Lipoprotein Receptor. Gong Y, Klein Wolterink RGJ, Janssen I, Groot AJ, Bos GMJ, Germeraad WTV. Mol Ther Methods Clin Dev. 2020 Mar 29;17:634-646. doi: 10.1016/j.omtm.2020.03.017. eCollection 2020 Jun 12. PubMed
Specialization for Cell-Free or Cell-to-Cell Spread of BAC-Cloned Human Cytomegalovirus Strains Is Determined by Factors beyond the UL128-131 and RL13 Loci. Schultz EP, Lanchy JM, Day LZ, Yu Q, Peterson C, Preece J, Ryckman BJ. J Virol. 2020 Jun 16;94(13). pii: JVI.00034-20. doi: 10.1128/JVI.00034-20. Print 2020 Jun 16. PubMed
Use of Transabdominal Ultrasound for the detection of intra-peritoneal tumor engraftment and growth in mouse xenografts of epithelial ovarian cancer. Chambers LM, Esakov E, Braley C, AlHilli M, Michener C, Reizes O. PLoS One. 2020 Apr 29;15(4):e0228511. doi: 10.1371/journal.pone.0228511. eCollection 2020. PubMed
UL88 Mediates the Incorporation of a Subset of Proteins into the Virion Tegument. Kumar R, Cruz L, Sandhu PK, Buchkovich NJ. J Virol. 2020 Jul 1;94(14). pii: JVI.00474-20. doi: 10.1128/JVI.00474-20. Print 2020 Jul 1. PubMed
Epithelial cell -derived microvesicles: A safe delivery platform of CRISPR/Cas9 conferring synergistic anti-tumor effect with sorafenib. He C, Jaffar Ali D, Xu H, Kumaravel S, Si K, Li Y, Sun B, Ma J, Xiao Z. Exp Cell Res. 2020 Jul 15;392(2):112040. doi: 10.1016/j.yexcr.2020.112040. Epub 2020 May 4. PubMed
Mucus blocks probiotics but increases penetration of motile pathogens and induces TNF-alpha and IL-8 secretion. Sharma A, Raman V, Lee J, Forbes NS. Biotechnol Bioeng. 2020 Aug;117(8):2540-2555. doi: 10.1002/bit.27383. Epub 2020 Jun 2. PubMed
Selective role of Nck1 in atherogenic inflammation and plaque formation. Alfaidi M, Acosta CH, Wang D, Traylor JG, Orr AW. J Clin Invest. 2020 Aug 3;130(8):4331-4347. doi: 10.1172/JCI135552. PubMed
HLTF Promotes Fork Reversal, Limiting Replication Stress Resistance and Preventing Multiple Mechanisms of Unrestrained DNA Synthesis. Bai G, Kermi C, Stoy H, Schiltz CJ, Bacal J, Zaino AM, Hadden MK, Eichman BF, Lopes M, Cimprich KA. Mol Cell. 2020 Jun 18;78(6):1237-1251.e7. doi: 10.1016/j.molcel.2020.04.031. Epub 2020 May 21. PubMed
Nck1, But Not Nck2, Mediates Disturbed Flow-Induced p21-Activated Kinase Activation and Endothelial Permeability. Alfaidi M, Bhattarai U, Orr AW. J Am Heart Assoc. 2020 Jun 2;9(11):e016099. doi: 10.1161/JAHA.120.016099. Epub 2020 May 29. PubMed
Frequent upregulation of G9a promotes RelB-dependent proliferation and survival in multiple myeloma. Zhang XY, Rajagopalan D, Chung TH, Hooi L, Toh TB, Tian JS, Rashid MBMA, Sahib NRBM, Gu M, Lim JJ, Wang W, Chng WJ, Jha S, Chow EK. Exp Hematol Oncol. 2020 May 22;9:8. doi: 10.1186/s40164-020-00164-4. eCollection 2020. PubMed
Protrudin-mediated ER-endosome contact sites promote MT1-MMP exocytosis and cell invasion. Pedersen NM, Wenzel EM, Wang L, Antoine S, Chavrier P, Stenmark H, Raiborg C. J Cell Biol. 2020 Aug 3;219(8). pii: 151827. doi: 10.1083/jcb.202003063. PubMed
Harnessing stemness and PD-L1 expression by AT-rich interaction domain-containing protein 3B in colorectal cancer. Liao TT, Lin CC, Jiang JK, Yang SH, Teng HW, Yang MH. Theranostics. 2020 May 15;10(14):6095-6112. doi: 10.7150/thno.44147. eCollection 2020. PubMed
Endogenous DNA 3' Blocks Are Vulnerabilities for BRCA1 and BRCA2 Deficiency and Are Reversed by the APE2 Nuclease. Alvarez-Quilon A, Wojtaszek JL, Mathieu MC, Patel T, Appel CD, Hustedt N, Rossi SE, Wallace BD, Setiaputra D, Adam S, Ohashi Y, Melo H, Cho T, Gervais C, Munoz IM, Grazzini E, Young JTF, Rouse J, Zinda M, Williams RS, Durocher D. Mol Cell. 2020 Jun 18;78(6):1152-1165.e8. doi: 10.1016/j.molcel.2020.05.021. Epub 2020 Jun 8. PubMed
Cell Type-Specific In Vitro Gene Expression Profiling of Stem Cell-Derived Neural Models. Gregory JA, Hoelzli E, Abdelaal R, Braine C, Cuevas M, Halpern M, Barretto N, Schrode N, Akbalik G, Kang K, Cheng E, Bowles K, Lotz S, Goderie S, Karch CM, Temple S, Goate A, Brennand KJ, Phatnani H. Cells. 2020 Jun 5;9(6). pii: cells9061406. doi: 10.3390/cells9061406. PubMed

Associated Plasmids

A Novel Function of Sphingosine Kinase 2 in the Metabolism of Sphinga-4,14-Diene Lipids. Couttas TA, Rustam YH, Song H, Qi Y, Teo JD, Chen J, Reid GE, Don AS. Metabolites. 2020 Jun 8;10(6). pii: metabo10060236. doi: 10.3390/metabo10060236. PubMed
Targeting FTO Suppresses Cancer Stem Cell Maintenance and Immune Evasion. Su R, Dong L, Li Y, Gao M, Han L, Wunderlich M, Deng X, Li H, Huang Y, Gao L, Li C, Zhao Z, Robinson S, Tan B, Qing Y, Qin X, Prince E, Xie J, Qin H, Li W, Shen C, Sun J, Kulkarni P, Weng H, Huang H, Chen Z, Zhang B, Wu X, Olsen MJ, Muschen M, Marcucci G, Salgia R, Li L, Fathi AT, Li Z, Mulloy JC, Wei M, Horne D, Chen J. Cancer Cell. 2020 Jul 13;38(1):79-96.e11. doi: 10.1016/j.ccell.2020.04.017. Epub 2020 Jun 11. PubMed
Epstein-Barr Virus LMP1 Promotes Syntenin-1- and Hrs-Induced Extracellular Vesicle Formation for Its Own Secretion To Increase Cell Proliferation and Migration. Nkosi D, Sun L, Duke LC, Patel N, Surapaneni SK, Singh M, Meckes DG Jr. mBio. 2020 Jun 16;11(3). pii: mBio.00589-20. doi: 10.1128/mBio.00589-20. PubMed
The guanine nucleotide exchange factor VAV3 participates in ERBB4-mediated cancer cell migration. Ojala VK, Knittle AM, Kirjalainen P, Merilahti JAM, Kortesoja M, Tvorogov D, Vaparanta K, Lin S, Kast J, Pulliainen AT, Kurppa KJ, Elenius K. J Biol Chem. 2020 Aug 14;295(33):11559-11571. doi: 10.1074/jbc.RA119.010925. Epub 2020 Jun 19. PubMed
Nonsense-mediated decay factor SMG7 sensitizes cells to TNFalpha-induced apoptosis via CYLD tumor suppressor and the noncoding oncogene Pvt1. Yang L, Kraft VAN, Pfeiffer S, Merl-Pham J, Bao X, An Y, Hauck SM, Schick JA. Mol Oncol. 2020 Jun 30. doi: 10.1002/1878-0261.12754. PubMed
Decipher the complexity of cis-regulatory regions by a modified Cas9. Kirchner S, Reuter S, Westphal A, Mrowka R. PLoS One. 2020 Jul 2;15(7):e0235530. doi: 10.1371/journal.pone.0235530. eCollection 2020. PubMed
Highly efficient 'hit-and-run' genome editing with unconcentrated lentivectors carrying Vpr.Prot.Cas9 protein produced from RRE-containing transcripts. Indikova I, Indik S. Nucleic Acids Res. 2020 Aug 20;48(14):8178-8187. doi: 10.1093/nar/gkaa561. PubMed
Overexpression of ER Protein Processing and Apoptosis Regulator Genes in Human Embryonic Kidney 293 Cells Improves Gene Therapy Vectors Production. Formas-Oliveira AS, Basilio JS, Rodrigues AF, Coroadinha AS. Biotechnol J. 2020 Jul 8:e1900562. doi: 10.1002/biot.201900562. PubMed
Kinetic Heterogeneity of Cancer Cell Fractional Killing. Inde Z, Forcina GC, Denton K, Dixon SJ. Cell Rep. 2020 Jul 7;32(1):107845. doi: 10.1016/j.celrep.2020.107845. PubMed

Associated Plasmids

Integrated Transcriptome and Network Analysis Reveals Spatiotemporal Dynamics of Calvarial Suturogenesis. Holmes G, Gonzalez-Reiche AS, Lu N, Zhou X, Rivera J, Kriti D, Sebra R, Williams AA, Donovan MJ, Potter SS, Pinto D, Zhang B, van Bakel H, Jabs EW. Cell Rep. 2020 Jul 7;32(1):107871. doi: 10.1016/j.celrep.2020.107871. PubMed
Transcriptional repression of PTEN in neural cells using CRISPR/dCas9 epigenetic editing. Moses C, Hodgetts SI, Nugent F, Ben-Ary G, Park KK, Blancafort P, Harvey AR. Sci Rep. 2020 Jul 9;10(1):11393. doi: 10.1038/s41598-020-68257-y. PubMed
Engineering Circulating Tumor Cells as Novel Cancer Theranostics. Parkins KM, Dubois VP, Kelly JJ, Chen Y, Knier NN, Foster PJ, Ronald JA. Theranostics. 2020 Jun 29;10(17):7925-7937. doi: 10.7150/thno.44259. eCollection 2020. PubMed
Nanosecond pulsed electric fields enhance mesenchymal stem cells differentiation via DNMT1-regulated OCT4/NANOG gene expression. Li K, Ning T, Wang H, Jiang Y, Zhang J, Ge Z. Stem Cell Res Ther. 2020 Jul 22;11(1):308. doi: 10.1186/s13287-020-01821-5. PubMed
PI3K-targeting strategy using alpelisib to enhance the antitumor effect of paclitaxel in human gastric cancer. Kim KJ, Kim JW, Sung JH, Suh KJ, Lee JY, Kim SH, Lee JO, Kim JW, Kim YJ, Kim JH, Bang SM, Lee JS, Kim HK, Lee KW. Sci Rep. 2020 Jul 23;10(1):12308. doi: 10.1038/s41598-020-68998-w. PubMed
Design and Evaluation of AgoshRNAs with 3'-Terminal HDV Ribozymes to Enhance the Silencing Activity. Berkhout B, Herrera-Carrillo E. Methods Mol Biol. 2021;2167:225-252. doi: 10.1007/978-1-0716-0716-9_13. PubMed
Srag Regulates Autophagy via Integrating into a Preexisting Autophagy Pathway in Testis. Cheng Y, Lai F, Wang X, Shang D, Zou J, Luo M, Xia X, Cheng H, Zhou R. Mol Biol Evol. 2021 Jan 4;38(1):128-141. doi: 10.1093/molbev/msaa195. PubMed
Lentiviral gene therapy vectors encoding VIP suppressed diabetes-related inflammation and augmented pancreatic beta-cell proliferation. Erendor F, Sahin EO, Sanlioglu AD, Balci MK, Griffith TS, Sanlioglu S. Gene Ther. 2021 Apr;28(3-4):130-141. doi: 10.1038/s41434-020-0183-3. Epub 2020 Jul 30. PubMed
Methods for the Study of Long Noncoding RNA in Cancer Cell Signaling. Feng Y, Jiang J, Hu Z, Yuan J, Zhang T, Pan Y, Xu M, Li C, Zhang Y, Zhang L, Hu X. Methods Mol Biol. 2021;2174:89-118. doi: 10.1007/978-1-0716-0759-6_7. PubMed
SRSF1 regulates exosome microRNA enrichment in human cancer cells. Xu YF, Xu X, Gin A, Nshimiyimana JD, Mooers BHM, Caputi M, Hannafon BN, Ding WQ. Cell Commun Signal. 2020 Aug 20;18(1):130. doi: 10.1186/s12964-020-00615-9. PubMed
Discovery of a Novel Chemical Scaffold Against Mutant Isocitrate Dehydrogenase 1 (IDH1). Kang CH, Choi SU, Son YH, Lee HK, Jeong HG, Yun CS, Ahn S, Park CH. Anticancer Res. 2020 Sep;40(9):4929-4935. doi: 10.21873/anticanres.14496. PubMed
A molecular sensor to quantify the localization of proteins, DNA and nanoparticles in cells. FitzGerald LI, Aurelio L, Chen M, Yuen D, Rennick JJ, Graham B, Johnston APR. Nat Commun. 2020 Sep 8;11(1):4482. doi: 10.1038/s41467-020-18082-8. PubMed

Associated Plasmids

Rabies VLPs adjuvanted with saponin-based liposomes induce enhanced immunogenicity mediated by neutralizing antibodies in cattle, dogs and cats. Fontana D, Marsili F, Etcheverrigaray M, Kratje R, Prieto C. J Virol Methods. 2020 Dec;286:113966. doi: 10.1016/j.jviromet.2020.113966. Epub 2020 Sep 6. PubMed
CCAAT/Enhancer-Binding Protein Delta (C/EBPdelta): A Previously Unrecognized Tumor Suppressor that Limits the Oncogenic Potential of Pancreatic Ductal Adenocarcinoma Cells. Hartl L, Duitman J, Aberson HL, Chen K, Dijk F, Roelofs JJTH, Dings MPG, Hooijer GKJ, Hernanda PY, Pan Q, Busch OR, Besselink MGH, Boerman T, Peppelenbosch MP, Bijlsma MF, Spek CA. Cancers (Basel). 2020 Sep 7;12(9). pii: cancers12092546. doi: 10.3390/cancers12092546. PubMed
In Vivo Reporter Assays Uncover Changes in Enhancer Activity Caused by Type 2 Diabetes-Associated Single Nucleotide Polymorphisms. Eufrasio A, Perrod C, Ferreira FJ, Duque M, Galhardo M, Bessa J. Diabetes. 2020 Dec;69(12):2794-2805. doi: 10.2337/db19-1049. Epub 2020 Sep 10. PubMed
Integration of Multiple Platforms for the Analysis of Multifluorescent Marking Technology Applied to Pediatric GBM and DIPG. Pericoli G, Petrini S, Giorda E, Ferretti R, Ajmone-Cat MA, Court W, Conti LA, De Simone R, Bencivenga P, Palma A, Di Giannatale A, Jones C, Carai A, Mastronuzzi A, de Billy E, Locatelli F, Vinci M. Int J Mol Sci. 2020 Sep 15;21(18). pii: ijms21186763. doi: 10.3390/ijms21186763. PubMed
The mechanistic role of alpha-synuclein in the nucleus: impaired nuclear function caused by familial Parkinson's disease SNCA mutations. Chen V, Moncalvo M, Tringali D, Tagliafierro L, Shriskanda A, Ilich E, Dong W, Kantor B, Chiba-Falek O. Hum Mol Genet. 2020 Nov 4;29(18):3107-3121. doi: 10.1093/hmg/ddaa183. PubMed
Pan-cancer multi-omics analysis and orthogonal experimental assessment of epigenetic driver genes. Halaburkova A, Cahais V, Novoloaca A, Araujo MGDS, Khoueiry R, Ghantous A, Herceg Z. Genome Res. 2020 Oct;30(10):1517-1532. doi: 10.1101/gr.268292.120. Epub 2020 Sep 22. PubMed
The stability of envelope-pseudotyped lentiviral vectors. Dautzenberg IJC, Rabelink MJWE, Hoeben RC. Gene Ther. 2021 Feb;28(1-2):89-104. doi: 10.1038/s41434-020-00193-y. Epub 2020 Sep 24. PubMed
Optimized Transgene Delivery Using Third-Generation Lentiviruses. Gill KP, Denham M. Curr Protoc Mol Biol. 2020 Dec;133(1):e125. doi: 10.1002/cpmb.125. PubMed
Co-culture Systems of Drug-Treated Acute Myeloid Leukemia Cells and T Cells for In Vitro and In Vivo Study. Li Y, Su R, Chen J. STAR Protoc. 2020 Sep 18;1(2). doi: 10.1016/j.xpro.2020.100097. Epub 2020 Aug 28. PubMed
Thermofluidic heat exchangers for actuation of transcription in artificial tissues. Corbett DC, Fabyan WB, Grigoryan B, O'Connor CE, Johansson F, Batalov I, Regier MC, DeForest CA, Miller JS, Stevens KR. Sci Adv. 2020 Sep 30;6(40). pii: 6/40/eabb9062. doi: 10.1126/sciadv.abb9062. Print 2020 Sep. PubMed
Orthotopic Bone Formation by Streamlined Engineering and Devitalization of Human Hypertrophic Cartilage. Pigeot S, Bourgine PE, Claude J, Scotti C, Papadimitropoulos A, Todorov A, Epple C, Peretti GM, Martin I. Int J Mol Sci. 2020 Sep 30;21(19). pii: ijms21197233. doi: 10.3390/ijms21197233. PubMed
Protein Disulphide Isomerase A1 Is Involved in the Regulation of Breast Cancer Cell Adhesion and Transmigration via Lung Microvascular Endothelial Cells. Stojak M, Milczarek M, Kurpinska A, Suraj-Prazmowska J, Kaczara P, Wojnar-Lason K, Banach J, Stachowicz-Suhs M, Rossowska J, Kalvins I, Wietrzyk J, Chlopicki S. Cancers (Basel). 2020 Oct 2;12(10). pii: cancers12102850. doi: 10.3390/cancers12102850. PubMed
SPATA33 is an autophagy mediator for cargo selectivity in germline mitophagy. Zhang Y, Xu X, Hu M, Wang X, Cheng H, Zhou R. Cell Death Differ. 2021 Mar;28(3):1076-1090. doi: 10.1038/s41418-020-00638-2. Epub 2020 Oct 21. PubMed
Role of the SIRT1/p53 regulatory axis in oxidative stressmediated granulosa cell apoptosis. Park SA, Joo NR, Park JH, Oh SM. Mol Med Rep. 2021 Jan;23(1). pii: 20. doi: 10.3892/mmr.2020.11658. Epub 2020 Nov 12. PubMed
SLX4IP Promotes Telomere Maintenance in Androgen Receptor-Independent Castration-Resistant Prostate Cancer through ALT-like Telomeric PML Localization. Mangosh TL, Awadallah WN, Grabowska MM, Taylor DJ. Mol Cancer Res. 2021 Feb;19(2):301-316. doi: 10.1158/1541-7786.MCR-20-0314. Epub 2020 Nov 13. PubMed
EZH2-mediated PP2A inactivation confers resistance to HER2-targeted breast cancer therapy. Bao Y, Oguz G, Lee WC, Lee PL, Ghosh K, Li J, Wang P, Lobie PE, Ehmsen S, Ditzel HJ, Wong A, Tan EY, Lee SC, Yu Q. Nat Commun. 2020 Nov 18;11(1):5878. doi: 10.1038/s41467-020-19704-x. PubMed
Evaluating the Genomic Parameters Governing rAAV-Mediated Homologous Recombination. Spector LP, Tiffany M, Ferraro NM, Abell NS, Montgomery SB, Kay MA. Mol Ther. 2021 Mar 3;29(3):1028-1046. doi: 10.1016/j.ymthe.2020.11.025. Epub 2020 Nov 26. PubMed
Silencing of the Long Noncoding RNA MYCNOS1 Suppresses Activity of MYCN-Amplified Retinoblastoma Without RB1 Mutation. Saengwimol D, Chittavanich P, Laosillapacharoen N, Srimongkol A, Chaitankar V, Rojanaporn D, Aroonroch R, Suktitipat B, Saisawang C, Svasti S, Hongeng S, Kaewkhaw R. Invest Ophthalmol Vis Sci. 2020 Dec 1;61(14):8. doi: 10.1167/iovs.61.14.8. PubMed
Identification of Potent CD19 scFv for CAR T Cells through scFv Screening with NK/T-Cell Line. Kang CH, Kim Y, Lee HK, Lee SM, Jeong HG, Choi SU, Park CH. Int J Mol Sci. 2020 Dec 1;21(23). pii: ijms21239163. doi: 10.3390/ijms21239163. PubMed
Activating transcription factor-4 promotes neuronal death induced by Parkinson's disease neurotoxins and alpha-synuclein aggregates. Demmings MD, Tennyson EC, Petroff GN, Tarnowski-Garner HE, Cregan SP. Cell Death Differ. 2021 May;28(5):1627-1643. doi: 10.1038/s41418-020-00688-6. Epub 2020 Dec 4. PubMed
Bidirectional perisomatic inhibitory plasticity of a Fos neuronal network. Yap EL, Pettit NL, Davis CP, Nagy MA, Harmin DA, Golden E, Dagliyan O, Lin C, Rudolph S, Sharma N, Griffith EC, Harvey CD, Greenberg ME. Nature. 2021 Feb;590(7844):115-121. doi: 10.1038/s41586-020-3031-0. Epub 2020 Dec 9. PubMed
SNAIL regulates gastric carcinogenesis through CCN3 and NEFL. Chen R, Masuo K, Yogo A, Yokoyama S, Sugiyama A, Seno H, Yoshizawa A, Takaishi S. Carcinogenesis. 2021 Feb 25;42(2):190-201. doi: 10.1093/carcin/bgaa133. PubMed
Resveratrol Activates Natural Killer Cells through Akt- and mTORC2-Mediated c-Myb Upregulation. Lee YJ, Kim J. Int J Mol Sci. 2020 Dec 16;21(24). pii: ijms21249575. doi: 10.3390/ijms21249575. PubMed
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Human DICER helicase domain recruits PKR and modulates its antiviral activity. Montavon TC, Baldaccini M, Lefevre M, Girardi E, Chane-Woon-Ming B, Messmer M, Hammann P, Chicher J, Pfeffer S. PLoS Pathog. 2021 May 13;17(5):e1009549. doi: 10.1371/journal.ppat.1009549. eCollection 2021 May. PubMed
Rab34 GTPase mediates ciliary membrane formation in the intracellular ciliogenesis pathway. Ganga AK, Kennedy MC, Oguchi ME, Gray S, Oliver KE, Knight TA, De La Cruz EM, Homma Y, Fukuda M, Breslow DK. Curr Biol. 2021 Jul 12;31(13):2895-2905.e7. doi: 10.1016/j.cub.2021.04.075. Epub 2021 May 13. PubMed
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Short lifespan of syngeneic transplanted MSC is a consequence of in vivo apoptosis and immune cell recruitment in mice. Preda MB, Neculachi CA, Fenyo IM, Vacaru AM, Publik MA, Simionescu M, Burlacu A. Cell Death Dis. 2021 Jun 2;12(6):566. doi: 10.1038/s41419-021-03839-w. PubMed
SLC26A6-selective inhibitor identified in a small-molecule screen blocks fluid absorption in small intestine. Cil O, Haggie PM, Tan JT, Rivera AA, Verkman AS. JCI Insight. 2021 Jun 8;6(11). pii: e147699. doi: 10.1172/jci.insight.147699. PubMed
Multiplex protein profiling method for extracellular vesicle protein detection. Sun L, Meckes DG Jr. Sci Rep. 2021 Jun 14;11(1):12477. doi: 10.1038/s41598-021-92012-6. PubMed
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The pan-cancer lncRNA PLANE regulates an alternative splicing program to promote cancer pathogenesis. Teng L, Feng YC, Guo ST, Wang PL, Qi TF, Yue YM, Wang SX, Zhang SN, Tang CX, La T, Zhang YY, Zhao XH, Gao JN, Wei LY, Zhang D, Wang JY, Shi Y, Liu XY, Li JM, Cao H, Liu T, Thorne RF, Jin L, Shao FM, Zhang XD. Nat Commun. 2021 Jun 18;12(1):3734. doi: 10.1038/s41467-021-24099-4. PubMed
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A flow cytometry-based assay for serological detection of anti-spike antibodies in COVID-19 patients. Goh YS, Ng LFP, Renia L. STAR Protoc. 2021 Sep 17;2(3):100671. doi: 10.1016/j.xpro.2021.100671. Epub 2021 Jun 19. PubMed
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Zika Virus Hijacks Extracellular Vesicle Tetraspanin Pathways for Cell-to-Cell Transmission. York SB, Sun L, Cone AS, Duke LC, Cheerathodi MR, Meckes DG Jr. mSphere. 2021 Jun 30:e0019221. doi: 10.1128/mSphere.00192-21. PubMed
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Associated Plasmids

Human cytomegalovirus expands a CD8(+) T cell population with loss of BCL11B expression and gain of NK cell identity. Sottile R, Panjwani MK, Lau CM, Daniyan AF, Tanaka K, Barker JN, Brentjens RJ, Sun JC, Le Luduec JB, Hsu KC. Sci Immunol. 2021 Sep 24;6(63):eabe6968. doi: 10.1126/sciimmunol.abe6968. Epub 2021 Sep 24. PubMed
A Compartmentalized Neuronal Cell-Culture Platform Compatible With Cryo-Fixation by High-Pressure Freezing for Ultrastructural Imaging. Tran HT, Lucas MS, Ishikawa T, Shahmoradian SH, Padeste C. Front Neurosci. 2021 Sep 8;15:726763. doi: 10.3389/fnins.2021.726763. eCollection 2021. PubMed
The Role of Pancreatic Alpha Cells and Endothelial Cells in the Reduction of Oxidative Stress in Pseudoislets. Wieland FC, Sthijns MMJPE, Geuens T, van Blitterswijk CA, LaPointe VLS. Front Bioeng Biotechnol. 2021 Sep 9;9:729057. doi: 10.3389/fbioe.2021.729057. eCollection 2021. PubMed

Associated Plasmids

Revisiting astrocyte to neuron conversion with lineage tracing in vivo. Wang LL, Serrano C, Zhong X, Ma S, Zou Y, Zhang CL. Cell. 2021 Oct 14;184(21):5465-5481.e16. doi: 10.1016/j.cell.2021.09.005. Epub 2021 Sep 27. PubMed

Associated Plasmids

Intravital imaging technology guides FAK-mediated priming in pancreatic cancer precision medicine according to Merlin status. Murphy KJ, Reed DA, Vennin C, Conway JRW, Nobis M, Yin JX, Chambers CR, Pereira BA, Lee V, Filipe EC, Trpceski M, Ritchie S, Lucas MC, Warren SC, Skhinas JN, Magenau A, Metcalf XL, Stoehr J, Major G, Parkin A, Bidanel R, Lyons RJ, Zaratzian A, Tayao M, Da Silva A, Abdulkhalek L, Gill AJ, Johns AL, Biankin AV, Samra J, Grimmond SM, Chou A, Goetz JG, Samuel MS, Lyons JG, Burgess A, Caldon CE, Horvath LG, Daly RJ, Gadegaard N, Wang Y, Sansom OJ, Morton JP, Cox TR, Pajic M, Herrmann D, Timpson P. Sci Adv. 2021 Oct;7(40):eabh0363. doi: 10.1126/sciadv.abh0363. Epub 2021 Sep 29. PubMed
Unraveling the functional role of DNA demethylation at specific promoters by targeted steric blockage of DNA methyltransferase with CRISPR/dCas9. Sapozhnikov DM, Szyf M. Nat Commun. 2021 Sep 29;12(1):5711. doi: 10.1038/s41467-021-25991-9. PubMed

Associated Plasmids

A highly potent antibody effective against SARS-CoV-2 variants of concern. Fenwick C, Turelli P, Perez L, Pellaton C, Esteves-Leuenberger L, Farina A, Campos J, Lana E, Fiscalini F, Raclot C, Pojer F, Lau K, Demurtas D, Descatoire M, Joo VS, Foglierini M, Noto A, Abdelnabi R, Foo CS, Vangeel L, Neyts J, Du W, Bosch BJ, Veldman G, Leyssen P, Thiel V, LeGrand R, Levy Y, Trono D, Pantaleo G. Cell Rep. 2021 Oct 12;37(2):109814. doi: 10.1016/j.celrep.2021.109814. Epub 2021 Sep 21. PubMed
IRAK1-dependent Regnase-1-14-3-3 complex formation controls Regnase-1-mediated mRNA decay. Akaki K, Ogata K, Yamauchi Y, Iwai N, Tse KM, Hia F, Mochizuki A, Ishihama Y, Mino T, Takeuchi O. Elife. 2021 Oct 12;10. pii: 71966. doi: 10.7554/eLife.71966. PubMed
Benzyl-para-di-[5-methyl-4-(n-octylamino) pyrimidin-2(1H)one] as an interferon beta (IFN-beta) modulator. Trifonov L, Yurchenko M, Skjesol A, Cohen G, Espevik T, Korshin EE, Grovdal LM, Husebye H, Gruzman A. Mol Divers. 2021 Oct 19. pii: 10.1007/s11030-021-10324-1. doi: 10.1007/s11030-021-10324-1. PubMed
Resistance of SARS-CoV-2 variants to neutralization by convalescent plasma from early COVID-19 outbreak in Singapore. Wang B, Goh YS, Prince T, Ngoh EZX, Salleh SNM, Hor PX, Loh CY, Fong SW, Hartley C, Tan SY, Young BE, Leo YS, Lye DC, Maurer-Stroh S, Ng LFP, Hiscox JA, Renia L, Wang CI. NPJ Vaccines. 2021 Oct 25;6(1):125. doi: 10.1038/s41541-021-00389-2. PubMed
GAS1 is required for NOTCH-dependent facilitation of SHH signaling in the ventral forebrain neuroepithelium. Marczenke M, Sunaga-Franze DY, Popp O, Althaus IW, Sauer S, Mertins P, Christ A, Allen BL, Willnow TE. Development. 2021 Nov 1;148(21). pii: 272617. doi: 10.1242/dev.200080. Epub 2021 Nov 11. PubMed
TIAM1-RAC1 promote small-cell lung cancer cell survival through antagonizing Nur77-induced BCL2 conformational change. Payapilly A, Guilbert R, Descamps T, White G, Magee P, Zhou C, Kerr A, Simpson KL, Blackhall F, Dive C, Malliri A. Cell Rep. 2021 Nov 9;37(6):109979. doi: 10.1016/j.celrep.2021.109979. PubMed
The phosphoinositide coincidence detector Phafin2 promotes macropinocytosis by coordinating actin organisation at forming macropinosomes. Schink KO, Tan KW, Spangenberg H, Martorana D, Sneeggen M, Stevenin V, Enninga J, Campsteijn C, Raiborg C, Stenmark H. Nat Commun. 2021 Nov 12;12(1):6577. doi: 10.1038/s41467-021-26775-x. PubMed
Soluble guanylate cyclase signalling mediates etoposide resistance in progressing small cell lung cancer. Schenk MW, Humphrey S, Hossain ASMM, Revill M, Pearsall S, Lallo A, Brown S, Bratt S, Galvin M, Descamps T, Zhou C, Pearce SP, Priest L, Greenhalgh M, Chaturvedi A, Kerr A, Blackhall F, Dive C, Frese KK. Nat Commun. 2021 Nov 17;12(1):6652. doi: 10.1038/s41467-021-26823-6. PubMed
Metabolically Activated Proteostasis Regulators Protect against Glutamate Toxicity by Activating NRF2. Rosarda JD, Baron KR, Nutsch K, Kline GM, Stanton C, Kelly JW, Bollong MJ, Wiseman RL. ACS Chem Biol. 2021 Dec 17;16(12):2852-2863. doi: 10.1021/acschembio.1c00810. Epub 2021 Nov 19. PubMed
DNA aptamers masking angiotensin converting enzyme 2 as an innovative way to treat SARS-CoV-2 pandemic. Villa A, Brunialti E, Dellavedova J, Meda C, Rebecchi M, Conti M, Donnici L, De Francesco R, Reggiani A, Lionetti V, Ciana P. Pharmacol Res. 2022 Jan;175:105982. doi: 10.1016/j.phrs.2021.105982. Epub 2021 Nov 16. PubMed
Production of human CAR-NK cells with lentiviral vectors and functional assessment in vitro. Portillo AL, Hogg R, Ashkar AA. STAR Protoc. 2021 Nov 17;2(4):100956. doi: 10.1016/j.xpro.2021.100956. eCollection 2021 Dec 17. PubMed
The Different Molecular Code in Generation of Dopaminergic Neurons from Astrocytes and Mesenchymal Stem Cells. Wang N, Ji X, Wu Y, Zhou S, Peng H, Wang J, Yu S, Zhang J. Int J Mol Sci. 2021 Nov 9;22(22). pii: ijms222212141. doi: 10.3390/ijms222212141. PubMed
The Fusion of CLEC12A and MIR223HG Arises from a trans-Splicing Event in Normal and Transformed Human Cells. Dhungel BP, Monteuuis G, Giardina C, Tabar MS, Feng Y, Metierre C, Ho S, Nagarajah R, Fontaine ARM, Shah JS, Gokal D, Bailey CG, Schmitz U, Rasko JEJ. Int J Mol Sci. 2021 Nov 10;22(22). pii: ijms222212178. doi: 10.3390/ijms222212178. PubMed
c-Met-Specific Chimeric Antigen Receptor T Cells Demonstrate Anti-Tumor Effect in c-Met Positive Gastric Cancer. Kang CH, Kim Y, Lee DY, Choi SU, Lee HK, Park CH. Cancers (Basel). 2021 Nov 16;13(22). pii: cancers13225738. doi: 10.3390/cancers13225738. PubMed
ELOVL2 promotes cancer progression by inhibiting cell apoptosis in renal cell carcinoma. Tanaka K, Kandori S, Sakka S, Nitta S, Tanuma K, Shiga M, Nagumo Y, Negoro H, Kojima T, Mathis BJ, Shimazui T, Watanabe M, Sato TA, Miyamoto T, Matsuzaka T, Shimano H, Nishiyama H. Oncol Rep. 2022 Feb;47(2). pii: 23. doi: 10.3892/or.2021.8234. Epub 2021 Nov 29. PubMed
Lentivirus-mediated Conditional Gene Expression. Rommereim L, Akhade AS, Germain RN, Fraser IDC, Subramanian N. Bio Protoc. 2021 Nov 5;11(21):e4205. doi: 10.21769/BioProtoc.4205. eCollection 2021 Nov 5. PubMed
Intersection of regulatory pathways controlling hemostasis and hemochorial placentation. Muto M, Chakraborty D, Varberg KM, Moreno-Irusta A, Iqbal K, Scott RL, McNally RP, Choudhury RH, Aplin JD, Okae H, Arima T, Matsumoto S, Ema M, Mast AE, Grundberg E, Soares MJ. Proc Natl Acad Sci U S A. 2021 Dec 14;118(50). pii: 2111267118. doi: 10.1073/pnas.2111267118. PubMed
Sphingosine 1-Phosphate Receptor 4 Promotes Nonalcoholic Steatohepatitis by Activating NLRP3 Inflammasome. Hong CH, Ko MS, Kim JH, Cho H, Lee CH, Yoon JE, Yun JY, Baek IJ, Jang JE, Lee SE, Cho YK, Baek JY, Oh SJ, Lee BY, Lim JS, Lee J, Hartig SM, Conde de la Rosa L, Garcia-Ruiz C, Lee KU, Fernandez-Checa JC, Choi JW, Kim S, Koh EH. Cell Mol Gastroenterol Hepatol. 2022;13(3):925-947. doi: 10.1016/j.jcmgh.2021.12.002. Epub 2021 Dec 8. PubMed
Rational design and construction of multi-copy biomanufacturing islands in mammalian cells. Altamura R, Doshi J, Benenson Y. Nucleic Acids Res. 2022 Jan 11;50(1):561-578. doi: 10.1093/nar/gkab1214. PubMed
Individual human cortical progenitors can produce excitatory and inhibitory neurons. Delgado RN, Allen DE, Keefe MG, Mancia Leon WR, Ziffra RS, Crouch EE, Alvarez-Buylla A, Nowakowski TJ. Nature. 2021 Dec 15. pii: 10.1038/s41586-021-04230-7. doi: 10.1038/s41586-021-04230-7. PubMed

Associated Plasmids

Single-cell delineation of lineage and genetic identity in the mouse brain. Bandler RC, Vitali I, Delgado RN, Ho MC, Dvoretskova E, Ibarra Molinas JS, Frazel PW, Mohammadkhani M, Machold R, Maedler S, Liddelow SA, Nowakowski TJ, Fishell G, Mayer C. Nature. 2022 Jan;601(7893):404-409. doi: 10.1038/s41586-021-04237-0. Epub 2021 Dec 15. PubMed
Development, Production, and Characterization of Hepatitis B Subviral Envelope Particles as a Third-Generation Vaccine. Battagliotti JM, Fontana D, Etcheverrigaray M, Kratje R, Prieto C. Methods Mol Biol. 2022;2410:273-287. doi: 10.1007/978-1-0716-1884-4_13. PubMed
An In Vivo CRISPR Screen Identifies Stepwise Genetic Dependencies of Metastatic Progression. Scheidmann MC, Castro-Giner F, Strittmatter K, Krol I, Paasinen-Sohns A, Scherrer R, Donato C, Gkountela S, Szczerba BM, Diamantopoulou Z, Muenst S, Vlajnic T, Kunz L, Vetter M, Rochlitz C, Taylor V, Giachino C, Schroeder T, Platt RJ, Aceto N. Cancer Res. 2022 Feb 15;82(4):681-694. doi: 10.1158/0008-5472.CAN-21-3908. PubMed
Confocal Imaging of Single-Cell Signaling in Orthotopic Models of Ovarian Cancer. Matvey DO, Ng TSC, Miller MA. Methods Mol Biol. 2022;2424:295-315. doi: 10.1007/978-1-0716-1956-8_19. PubMed
Contribution of protein-protein interactions to the endothelial-barrier-stabilizing function of KRIT1. Swamy H, Glading AJ. J Cell Sci. 2022 Jan 15;135(2). pii: 274104. doi: 10.1242/jcs.258816. Epub 2022 Jan 25. PubMed
A novel role for gag as a cis-acting element regulating RNA structure, dimerization and packaging in HIV-1 lentiviral vectors. Vamva E, Griffiths A, Vink CA, Lever AML, Kenyon JC. Nucleic Acids Res. 2022 Jan 11;50(1):430-448. doi: 10.1093/nar/gkab1206. PubMed
Platelet Endothelial Cell Adhesion Molecule 1 (CD31) Is Essential for Clostridium perfringens Beta-Toxin Mediated Cytotoxicity in Human Endothelial and Monocytic Cells. Tarek B, Bruggisser J, Cattalani F, Posthaus H. Toxins (Basel). 2021 Dec 13;13(12). pii: toxins13120893. doi: 10.3390/toxins13120893. PubMed
Patient-Derived Xenografts of High-Grade Serous Ovarian Cancer Subtype as a Powerful Tool in Pre-Clinical Research. Cybula M, Wang L, Wang L, Drumond-Bock AL, Moxley KM, Benbrook DM, Gunderson-Jackson C, Ruiz-Echevarria MJ, Bhattacharya R, Mukherjee P, Bieniasz M. Cancers (Basel). 2021 Dec 15;13(24). pii: cancers13246288. doi: 10.3390/cancers13246288. PubMed
Entrectinib-A SARS-CoV-2 Inhibitor in Human Lung Tissue (HLT) Cells. Peralta-Garcia A, Torrens-Fontanals M, Stepniewski TM, Grau-Exposito J, Perea D, Ayinampudi V, Waldhoer M, Zimmermann M, Buzon MJ, Genesca M, Selent J. Int J Mol Sci. 2021 Dec 18;22(24). pii: ijms222413592. doi: 10.3390/ijms222413592. PubMed
Etched 3D-Printed Polycaprolactone Constructs Functionalized with Reduced Graphene Oxide for Enhanced Attachment of Dental Pulp-Derived Stem Cells. Bow AJ, Masi TJ, Dhar MS. Pharmaceutics. 2021 Dec 13;13(12). pii: pharmaceutics13122146. doi: 10.3390/pharmaceutics13122146. PubMed
Intestinal organoid co-culture protocol to study cell competition in vitro. van Neerven SM, Ramadan R, van Driel MS, Huels DJ, Vermeulen L. STAR Protoc. 2021 Dec 16;3(1):101050. doi: 10.1016/j.xpro.2021.101050. eCollection 2022 Mar 18. PubMed
Epigenetic regulation of ferroptosis via ETS1/miR-23a-3p/ACSL4 axis mediates sorafenib resistance in human hepatocellular carcinoma. Lu Y, Chan YT, Tan HY, Zhang C, Guo W, Xu Y, Sharma R, Chen ZS, Zheng YC, Wang N, Feng Y. J Exp Clin Cancer Res. 2022 Jan 3;41(1):3. doi: 10.1186/s13046-021-02208-x. PubMed
Engineered small extracellular vesicles displaying ACE2 variants on the surface protect against SARS-CoV-2 infection. Kim HK, Cho J, Kim E, Kim J, Yang JS, Kim KC, Lee JY, Shin Y, Palomera LF, Park J, Baek SH, Bae HG, Cho Y, Han J, Sul JH, Lee J, Park JH, Cho YW, Lee W, Jo DG. J Extracell Vesicles. 2022 Jan;11(1):e12179. doi: 10.1002/jev2.12179. PubMed
Decreased memory B cell frequencies in COVID-19 delta variant vaccine breakthrough infection. Tay MZ, Rouers A, Fong SW, Goh YS, Chan YH, Chang ZW, Xu W, Tan CW, Chia WN, Torres-Ruesta A, Amrun SN, Huang Y, Hor PX, Loh CY, Yeo NK, Wang B, Ngoh EZX, Salleh SNM, Chavatte JM, Lim AJ, Maurer-Stroh S, Wang LF, Lin RVTP, Wang CI, Tan SY, Young BE, Leo YS, Lye DC, Renia L, Ng LF. EMBO Mol Med. 2022 Mar 7;14(3):e15227. doi: 10.15252/emmm.202115227. Epub 2022 Jan 21. PubMed
A Two-tiered functional screen identifies herpesviral transcriptional modifiers and their essential domains. Morgens DW, Nandakumar D, Didychuk AL, Yang KJ, Glaunsinger BA. PLoS Pathog. 2022 Jan 18;18(1):e1010236. doi: 10.1371/journal.ppat.1010236. eCollection 2022 Jan. PubMed

Associated Plasmids

The Immune-Specific E3 Ubiquitin Ligase MARCH1 Is Upregulated during Human Cytomegalovirus Infection to Regulate Iron Levels. Martin M, Sandhu P, Kumar R, Buchkovich NJ. J Virol. 2022 Mar 23;96(6):e0180621. doi: 10.1128/jvi.01806-21. Epub 2022 Jan 19. PubMed
Presynaptic mechanisms underlying GABA(B)-receptor-mediated inhibition of spontaneous neurotransmitter release. Alten B, Guzikowski NJ, Zurawski Z, Hamm HE, Kavalali ET. Cell Rep. 2022 Jan 18;38(3):110255. doi: 10.1016/j.celrep.2021.110255. PubMed
Adipocyte-Specific Inhibition of Mir221/222 Ameliorates Diet-Induced Obesity Through Targeting Ddit4. Yamaguchi S, Zhang D, Katayama A, Kurooka N, Sugawara R, Albuayjan HHH, Nakatsuka A, Eguchi J, Wada J. Front Endocrinol (Lausanne). 2022 Jan 3;12:750261. doi: 10.3389/fendo.2021.750261. eCollection 2021. PubMed
CRISPR-Cas9 Screen Identifies DYRK1A as a Target for Radiotherapy Sensitization in Pancreatic Cancer. Lan B, Zeng S, Zhang S, Ren X, Xing Y, Kutschick I, Pfeffer S, Frey B, Britzen-Laurent N, Grutzmann R, Cordes N, Pilarsky C. Cancers (Basel). 2022 Jan 10;14(2). pii: cancers14020326. doi: 10.3390/cancers14020326. PubMed
Canonical WNT pathway inhibition reduces ATP synthesis rates in glioblastoma stem cells. Ouwens DM, Hewera M, Li G, Di W, Muhammad S, Hanggi D, Steiger HJ, Dumitru CA, Sandalcioglu E, Croner RS, Zhang W, Kakhlon O, Kahlert UD. Front Biosci (Landmark Ed). 2022 Jan 18;27(1):35. doi: 10.31083/j.fbl2701035. PubMed
Isolation and characterization of the immune cell fraction from murine brain tumor microenvironment. Mastandrea I, Sher D, Magod P, Friedmann-Morvinski D. STAR Protoc. 2022 Jan 20;3(1):101106. doi: 10.1016/j.xpro.2021.101106. eCollection 2022 Mar 18. PubMed
Protein Allostery and Ligand Design: Computational Design Meets Experiments to Discover Novel Chemical Probes. Triveri A, Sanchez-Martin C, Torielli L, Serapian SA, Marchetti F, D'Acerno G, Pirota V, Castelli M, Moroni E, Ferraro M, Quadrelli P, Rasola A, Colombo G. J Mol Biol. 2022 Sep 15;434(17):167468. doi: 10.1016/j.jmb.2022.167468. Epub 2022 Jan 29. PubMed
Histone acetylome-wide associations in immune cells from individuals with active Mycobacterium tuberculosis infection. Del Rosario RCH, Poschmann J, Lim C, Cheng CY, Kumar P, Riou C, Ong ST, Gerges S, Hajan HS, Kumar D, Marzuki M, Lu X, Lee A, Wijaya GC, Rayan NA, Zhuang Z, Du Bruyn E, Chee CBE, Lee B, Lum J, Zolezzi F, Poidinger M, Rotzschke O, Khor CC, Wilkinson RJ, Wang YT, Chandy GK, De Libero G, Singhal A, Prabhakar S. Nat Microbiol. 2022 Feb;7(2):312-326. doi: 10.1038/s41564-021-01049-w. Epub 2022 Jan 31. PubMed
Oxidative pentose phosphate pathway controls vascular mural cell coverage by regulating extracellular matrix composition. Facchinello N, Astone M, Audano M, Oberkersch RE, Spizzotin M, Calura E, Marques M, Crisan M, Mitro N, Santoro MM. Nat Metab. 2022 Jan;4(1):123-140. doi: 10.1038/s42255-021-00514-4. Epub 2022 Jan 27. PubMed
A human antibody reveals a conserved site on beta-coronavirus spike proteins and confers protection against SARS-CoV-2 infection. Zhou P, Yuan M, Song G, Beutler N, Shaabani N, Huang D, He WT, Zhu X, Callaghan S, Yong P, Anzanello F, Peng L, Ricketts J, Parren M, Garcia E, Rawlings SA, Smith DM, Nemazee D, Teijaro JR, Rogers TF, Wilson IA, Burton DR, Andrabi R. Sci Transl Med. 2022 Mar 23;14(637):eabi9215. doi: 10.1126/scitranslmed.abi9215. Epub 2022 Mar 23. PubMed
Pathway-specific effects of ADSL deficiency on neurodevelopment. Dutto I, Gerhards J, Herrera A, Souckova O, Skopova V, Smak JA, Junza A, Yanes O, Boeckx C, Burkhalter MD, Zikanova M, Pons S, Philipp M, Luders J, Stracker TH. Elife. 2022 Feb 8;11. pii: 70518. doi: 10.7554/eLife.70518. PubMed
METTL16 exerts an m(6)A-independent function to facilitate translation and tumorigenesis. Su R, Dong L, Li Y, Gao M, He PC, Liu W, Wei J, Zhao Z, Gao L, Han L, Deng X, Li C, Prince E, Tan B, Qing Y, Qin X, Shen C, Xue M, Zhou K, Chen Z, Xue J, Li W, Qin H, Wu X, Sun M, Nam Y, Chen CW, Huang W, Horne D, Rosen ST, He C, Chen J. Nat Cell Biol. 2022 Feb;24(2):205-216. doi: 10.1038/s41556-021-00835-2. Epub 2022 Feb 10. PubMed
A Human-derived Dual MRI/PET Reporter Gene System with High Translational Potential for Cell Tracking. Shalaby N, Kelly J, Martinez F, Fox M, Qi Q, Thiessen J, Hicks J, Scholl TJ, Ronald JA. Mol Imaging Biol. 2022 Apr;24(2):341-351. doi: 10.1007/s11307-021-01697-8. Epub 2022 Feb 10. PubMed
Follistatin promotes LIN28B-mediated supporting cell reprogramming and hair cell regeneration in the murine cochlea. Li XJ, Morgan C, Goff LA, Doetzlhofer A. Sci Adv. 2022 Feb 11;8(6):eabj7651. doi: 10.1126/sciadv.abj7651. Epub 2022 Feb 11. PubMed
Longitudinal Monitoring of Intra-Tumoural Heterogeneity Using Optical Barcoding of Patient-Derived Colorectal Tumour Models. Shembrey C, Smith J, Grandin M, Williams N, Cho HJ, Molck C, Behrenbruch C, Thomson BN, Heriot AG, Merino D, Hollande F. Cancers (Basel). 2022 Jan 24;14(3). pii: cancers14030581. doi: 10.3390/cancers14030581. PubMed
Combinatorial Approach of Binary Colloidal Crystals and CRISPR Activation to Improve Induced Pluripotent Stem Cell Differentiation into Neurons. Urrutia-Cabrera D, Hsiang-Chi Liou R, Lin J, Shi Y, Liu K, Hung SSC, Hewitt AW, Wang PY, Ching-Bong Wong R. ACS Appl Mater Interfaces. 2022 Feb 23;14(7):8669-8679. doi: 10.1021/acsami.1c17975. Epub 2022 Feb 15. PubMed
Ferritin-Nanocaged ATP Traverses the Blood-Testis Barrier and Enhances Sperm Motility in an Asthenozoospermia Model. Pang J, Feng X, Liang Q, Zheng X, Duan Y, Zhang X, Zhang J, Chen Y, Fan K, Gao L, Li J. ACS Nano. 2022 Mar 22;16(3):4175-4185. doi: 10.1021/acsnano.1c10029. Epub 2022 Feb 15. PubMed
Development of human alveolar epithelial cell models to study distal lung biology and disease. Tran E, Shi T, Li X, Chowdhury AY, Jiang D, Liu Y, Wang H, Yan C, Wallace WD, Lu R, Ryan AL, Marconett CN, Zhou B, Borok Z, Offringa IA. iScience. 2022 Jan 15;25(2):103780. doi: 10.1016/j.isci.2022.103780. eCollection 2022 Feb 18. PubMed
Targeted isolation of panels of diverse human protective broadly neutralizing antibodies against SARS-like viruses. He WT, Musharrafieh R, Song G, Dueker K, Tse LV, Martinez DR, Schafer A, Callaghan S, Yong P, Beutler N, Torres JL, Volk RM, Zhou P, Yuan M, Liu H, Anzanello F, Capozzola T, Parren M, Garcia E, Rawlings SA, Smith DM, Wilson IA, Safonova Y, Ward AB, Rogers TF, Baric RS, Gralinski LE, Burton DR, Andrabi R. bioRxiv. 2022 Feb 8:2021.09.08.459480. doi: 10.1101/2021.09.08.459480. Preprint. PubMed
PMS2 variant results in loss of ATPase activity without compromising mismatch repair. D'Arcy BM, Arrington J, Weisman J, McClellan SB, Vandana, Yang Z, Deivanayagam C, Blount J, Prakash A. Mol Genet Genomic Med. 2022 Feb 21:e1908. doi: 10.1002/mgg3.1908. PubMed
The Natural Chemotherapeutic Capsaicin Activates AMPK through LKB1 Kinase and TRPV1 Receptors in Prostate Cancer Cells. Sanchez BG, Bort A, Mora-Rodriguez JM, Diaz-Laviada I. Pharmaceutics. 2022 Jan 29;14(2). pii: pharmaceutics14020329. doi: 10.3390/pharmaceutics14020329. PubMed
Plasmalogens, the Vinyl Ether-Linked Glycerophospholipids, Enhance Learning and Memory by Regulating Brain-Derived Neurotrophic Factor. Hossain MS, Mawatari S, Fujino T. Front Cell Dev Biol. 2022 Feb 9;10:828282. doi: 10.3389/fcell.2022.828282. eCollection 2022. PubMed
DELETE_Ferroptosis regulation by the NGLY1/NFE2L1 pathway. Forcina GC, Pope L, Murray M, Dong W, Abu-Remaileh M, Bertozzi CR, Dixon SJ. Proc Natl Acad Sci U S A. 2022 Mar 15;119(11):e2118646119. doi: 10.1073/pnas.2118646119. Epub 2022 Mar 10. PubMed
The response of three-dimensional pancreatic alpha and beta cell co-cultures to oxidative stress. Sthijns MMJPE, Rademakers T, Oosterveer J, Geuens T, van Blitterswijk CA, LaPointe VLS. PLoS One. 2022 Mar 15;17(3):e0257578. doi: 10.1371/journal.pone.0257578. eCollection 2022. PubMed
Broadly neutralizing anti-S2 antibodies protect against all three human betacoronaviruses that cause deadly disease. Zhou P, Song G, Liu H, Yuan M, He WT, Beutler N, Zhu X, Tse LV, Martinez DR, Schafer A, Anzanello F, Yong P, Peng L, Dueker K, Musharrafieh R, Callaghan S, Capozzola T, Limbo O, Parren M, Garcia E, Rawlings SA, Smith DM, Nemazee D, Jardine JG, Safonova Y, Briney B, Rogers TF, Wilson IA, Baric RS, Gralinski LE, Burton DR, Andrabi R. Immunity. 2023 Mar 14;56(3):669-686.e7. doi: 10.1016/j.immuni.2023.02.005. Epub 2023 Feb 16. PubMed

Associated Plasmids

PRMT5 regulates ATF4 transcript splicing and oxidative stress response. Szewczyk MM, Luciani GM, Vu V, Murison A, Dilworth D, Barghout SH, Lupien M, Arrowsmith CH, Minden MD, Barsyte-Lovejoy D. Redox Biol. 2022 May;51:102282. doi: 10.1016/j.redox.2022.102282. Epub 2022 Mar 11. PubMed
Down-regulation of the transcriptional repressor ZNF802 (JAZF1) reactivates fetal hemoglobin in beta(0)-thalassemia/HbE. Wongborisuth C, Chumchuen S, Sripichai O, Anurathaphan U, Sathirapongsasuti N, Songdej D, Tangprasittipap A, Hongeng S. Sci Rep. 2022 Mar 23;12(1):4952. doi: 10.1038/s41598-022-08920-8. PubMed
Identification of SARS-CoV-2 Spike Palmitoylation Inhibitors That Results in Release of Attenuated Virus with Reduced Infectivity. Ramadan AA, Mayilsamy K, McGill AR, Ghosh A, Giulianotti MA, Donow HM, Mohapatra SS, Mohapatra S, Chandran B, Deschenes RJ, Roy A. Viruses. 2022 Mar 4;14(3). pii: v14030531. doi: 10.3390/v14030531. PubMed
Efficient silencing of hepatitis B virus S gene through CRISPR-mediated base editing. Zhou H, Wang X, Steer CJ, Song G, Niu J. Hepatol Commun. 2022 Jul;6(7):1652-1663. doi: 10.1002/hep4.1933. Epub 2022 Mar 26. PubMed
Crystal structure and cellular functions of uPAR dimer. Yu S, Sui Y, Wang J, Li Y, Li H, Cao Y, Chen L, Jiang L, Yuan C, Huang M. Nat Commun. 2022 Mar 29;13(1):1665. doi: 10.1038/s41467-022-29344-y. PubMed
Synapse topology and downmodulation events determine the functional outcome of anti-CD19 T cell-redirecting strategies. Ramirez-Fernandez A, Aguilar-Sopena O, Diez-Alonso L, Segura-Tudela A, Dominguez-Alonso C, Roda-Navarro P, Alvarez-Vallina L, Blanco B. Oncoimmunology. 2022 Mar 23;11(1):2054106. doi: 10.1080/2162402X.2022.2054106. eCollection 2022. PubMed
Tumor growth of neurofibromin-deficient cells is driven by decreased respiration and hampered by NAD(+) and SIRT3. Masgras I, Cannino G, Ciscato F, Sanchez-Martin C, Darvishi FB, Scantamburlo F, Pizzi M, Menga A, Fregona D, Castegna A, Rasola A. Cell Death Differ. 2022 Apr 7. pii: 10.1038/s41418-022-00991-4. doi: 10.1038/s41418-022-00991-4. PubMed
Neutrophil Protein Kinase R Mediates Endothelial Adhesion and Migration by the Promotion of Neutrophil Actin Polymerization. Inoue R, Nishi H, Osaka M, Yoshida M, Nangaku M. J Immunol. 2022 May 1;208(9):2173-2183. doi: 10.4049/jimmunol.2001349. Epub 2022 Apr 8. PubMed
ATRX-Deficient High-Grade Glioma Cells Exhibit Increased Sensitivity to RTK and PDGFR Inhibitors. Pladevall-Morera D, Castejon-Grinan M, Aguilera P, Gaardahl K, Ingham A, Brosnan-Cashman JA, Meeker AK, Lopez-Contreras AJ. Cancers (Basel). 2022 Mar 31;14(7). pii: cancers14071790. doi: 10.3390/cancers14071790. PubMed
Cadherin-11 Influences Differentiation in Human Mesenchymal Stem Cells by Regulating the Extracellular Matrix Via the TGFbeta1 Pathway. Passanha FR, Geuens T, LaPointe VLS. Stem Cells. 2022 Jul 27;40(7):669-677. doi: 10.1093/stmcls/sxac026. PubMed
Synaptic vesicle binding of alpha-synuclein is modulated by beta- and gamma-synucleins. Carnazza KE, Komer LE, Xie YX, Pineda A, Briano JA, Gao V, Na Y, Ramlall T, Buchman VL, Eliezer D, Sharma M, Burre J. Cell Rep. 2022 Apr 12;39(2):110675. doi: 10.1016/j.celrep.2022.110675. PubMed
Synthetic carbohydrate-binding agents neutralize SARS-CoV-2 by inhibiting binding of the spike protein to ACE2. Francesconi O, Donnici L, Fragai M, Pesce E, Bombaci M, Fasciani A, Manganaro L, Conti M, Grifantini R, De Francesco R, Nativi C, Roelens S. iScience. 2022 May 20;25(5):104239. doi: 10.1016/j.isci.2022.104239. Epub 2022 Apr 11. PubMed
CCNE1 amplification is synthetic lethal with PKMYT1 kinase inhibition. Gallo D, Young JTF, Fourtounis J, Martino G, Alvarez-Quilon A, Bernier C, Duffy NM, Papp R, Roulston A, Stocco R, Szychowski J, Veloso A, Alam H, Baruah PS, Fortin AB, Bowlan J, Chaudhary N, Desjardins J, Dietrich E, Fournier S, Fugere-Desjardins C, Goullet de Rugy T, Leclaire ME, Liu B, Bhaskaran V, Mamane Y, Melo H, Nicolas O, Singhania A, Szilard RK, Tkac J, Yin SY, Morris SJ, Zinda M, Marshall CG, Durocher D. Nature. 2022 Apr;604(7907):749-756. doi: 10.1038/s41586-022-04638-9. Epub 2022 Apr 20. PubMed
Selective ferroptosis vulnerability due to familial Alzheimer's disease presenilin mutations. Greenough MA, Lane DJR, Balez R, Anastacio HTD, Zeng Z, Ganio K, McDevitt CA, Acevedo K, Belaidi AA, Koistinaho J, Ooi L, Ayton S, Bush AI. Cell Death Differ. 2022 Apr 21. pii: 10.1038/s41418-022-01003-1. doi: 10.1038/s41418-022-01003-1. PubMed
Developing all-in-one virus-like particles for Cas9 mRNA/single guide RNA co-delivery and aptamer-containing lentiviral vectors for improved gene expression. Yadav M, Atala A, Lu B. Int J Biol Macromol. 2022 Jun 1;209(Pt A):1260-1270. doi: 10.1016/j.ijbiomac.2022.04.114. Epub 2022 Apr 22. PubMed
Nonlinear mechanics of human mitotic chromosomes. Meijering AEC, Sarlos K, Nielsen CF, Witt H, Harju J, Kerklingh E, Haasnoot GH, Bizard AH, Heller I, Broedersz CP, Liu Y, Peterman EJG, Hickson ID, Wuite GJL. Nature. 2022 May;605(7910):545-550. doi: 10.1038/s41586-022-04666-5. Epub 2022 May 4. PubMed
Inhibition of pyrimidine biosynthesis targets protein translation in acute myeloid leukemia. So J, Lewis AC, Smith LK, Stanley K, Franich R, Yoannidis D, Pijpers L, Dominguez P, Hogg SJ, Vervoort SJ, Brown FC, Johnstone RW, McDonald G, Ulanet DB, Murtie J, Gruber E, Kats LM. EMBO Mol Med. 2022 Jul 7;14(7):e15203. doi: 10.15252/emmm.202115203. Epub 2022 May 6. PubMed
OXSR1 inhibits inflammasome activation by limiting potassium efflux during mycobacterial infection. Hortle E, Tran VL, Wright K, Fontaine AR, Pinello N, O'Rourke MB, Wong JJ, Hansbro PM, Britton WJ, Oehlers SH. Life Sci Alliance. 2022 May 11;5(9):e202201476. doi: 10.26508/lsa.202201476. Print 2022 Sep. PubMed
Structural insights of a highly potent pan-neutralizing SARS-CoV-2 human monoclonal antibody. Torres JL, Ozorowski G, Andreano E, Liu H, Copps J, Piccini G, Donnici L, Conti M, Planchais C, Planas D, Manganaro N, Pantano E, Paciello I, Pileri P, Bruel T, Montomoli E, Mouquet H, Schwartz O, Sala C, De Francesco R, Wilson IA, Rappuoli R, Ward AB. Proc Natl Acad Sci U S A. 2022 May 17;119(20):e2120976119. doi: 10.1073/pnas.2120976119. Epub 2022 May 12. PubMed
DVL1 and DVL3 require nuclear localisation to regulate proliferation in human myoblasts. Pruller J, Figeac N, Zammit PS. Sci Rep. 2022 May 19;12(1):8388. doi: 10.1038/s41598-022-10536-x. PubMed
Finger stick blood test to assess postvaccination SARS-CoV-2 neutralizing antibody response against variants. Lim SM, Cheng HL, Jia H, Kongsuphol P, D/O Shunmuganathan B, Chen MW, Ng SY, Gao X, Turaga SP, Heussler SP, Somani J, Sengupta S, Tay DMY, McBee ME, Young BE, MacAry PA, Sikes HD, Preiser PR. Bioeng Transl Med. 2022 Feb 10;7(2):e10293. doi: 10.1002/btm2.10293. eCollection 2022 May. PubMed
A rapid simple point-of-care assay for the detection of SARS-CoV-2 neutralizing antibodies. Kongsuphol P, Jia H, Cheng HL, Gu Y, Shunmuganathan BD, Chen MW, Lim SM, Ng SY, Tambyah PA, Nasir H, Gao X, Tay D, Kim S, Gupta R, Qian X, Kozma MM, Purushotorman K, McBee ME, MacAry PA, Sikes HD, Preiser PR. Commun Med (Lond). 2021 Nov 11;1:46. doi: 10.1038/s43856-021-00045-9. eCollection 2021. PubMed
[Multimodal Magnetic Resonance and Fluorescence Imaging of the Induced Pluripotent Stem Cell Transplantation in the Brain]. Zhang YC, Wang JW, Wu Y, Tao Q, Wang FF, Wang N, Ji XR, Li YG, Yu S, Zhang JZ. Mol Biol (Mosk). 2022 May-Jun;56(3):500-502. doi: 10.31857/S002689842203020X. PubMed
AURKA and PLK1 inhibition selectively and synergistically block cell cycle progression in diffuse midline glioma. Metselaar DS, du Chatinier A, Meel MH, Ter Huizen G, Waranecki P, Goulding JR, Bugiani M, Koster J, Kaspers GJL, Hulleman E. iScience. 2022 May 13;25(6):104398. doi: 10.1016/j.isci.2022.104398. eCollection 2022 Jun 17. PubMed
High-throughput drug screening allowed identification of entry inhibitors specifically targeting different routes of SARS-CoV-2 Delta and Omicron/BA.1. Kuzikov M, Woens J, Zaliani A, Hambach J, Eden T, Fehse B, Ellinger B, Riecken K. Biomed Pharmacother. 2022 Jul;151:113104. doi: 10.1016/j.biopha.2022.113104. Epub 2022 May 16. PubMed
Allosteric regulation of noncoding RNA function by microRNAs. Gorbea C, Elhakiem A, Cazalla D. Nucleic Acids Res. 2022 Jun 24;50(11):6511-6520. doi: 10.1093/nar/gkac443. PubMed
Mapping cis-regulatory elements in human neurons links psychiatric disease heritability and activity-regulated transcriptional programs. Sanchez-Priego C, Hu R, Boshans LL, Lalli M, Janas JA, Williams SE, Dong Z, Yang N. Cell Rep. 2022 May 31;39(9):110877. doi: 10.1016/j.celrep.2022.110877. PubMed
Targeted isolation of diverse human protective broadly neutralizing antibodies against SARS-like viruses. He WT, Musharrafieh R, Song G, Dueker K, Tse LV, Martinez DR, Schafer A, Callaghan S, Yong P, Beutler N, Torres JL, Volk RM, Zhou P, Yuan M, Liu H, Anzanello F, Capozzola T, Parren M, Garcia E, Rawlings SA, Smith DM, Wilson IA, Safonova Y, Ward AB, Rogers TF, Baric RS, Gralinski LE, Burton DR, Andrabi R. Nat Immunol. 2022 Jun;23(6):960-970. doi: 10.1038/s41590-022-01222-1. Epub 2022 Jun 2. PubMed
TrackMate 7: integrating state-of-the-art segmentation algorithms into tracking pipelines. Ershov D, Phan MS, Pylvanainen JW, Rigaud SU, Le Blanc L, Charles-Orszag A, Conway JRW, Laine RF, Roy NH, Bonazzi D, Dumenil G, Jacquemet G, Tinevez JY. Nat Methods. 2022 Jul;19(7):829-832. doi: 10.1038/s41592-022-01507-1. Epub 2022 Jun 2. PubMed
Inhibition of a Chromatin and Transcription Modulator, SLTM, Increases HIV-1 Reactivation Identified by a CRISPR Inhibition Screen. Pedersen SF, Collora JA, Kim RN, Yang K, Razmi A, Catalano AA, Yeh YJ, Mounzer K, Tebas P, Montaner LJ, Ho YC. J Virol. 2022 Jul 13;96(13):e0057722. doi: 10.1128/jvi.00577-22. Epub 2022 Jun 22. PubMed
Oxidative stress from DGAT1 oncoprotein inhibition in melanoma suppresses tumor growth when ROS defenses are also breached. Wilcock DJ, Badrock AP, Wong CW, Owen R, Guerin M, Southam AD, Johnston H, Telfer BA, Fullwood P, Watson J, Ferguson H, Ferguson J, Lloyd GR, Jankevics A, Dunn WB, Wellbrock C, Lorigan P, Ceol C, Francavilla C, Smith MP, Hurlstone AFL. Cell Rep. 2022 Jun 21;39(12):110995. doi: 10.1016/j.celrep.2022.110995. PubMed
Novel luciferase-based glucagon-like peptide 1 reporter assay reveals naturally occurring secretagogues. Anghel SA, Badea RA, Chiritoiu G, Patriche DS, Alexandru PR, Pena F. Br J Pharmacol. 2022 Oct;179(19):4738-4753. doi: 10.1111/bph.15896. Epub 2022 Jul 21. PubMed
Wiskott-Aldrich syndrome protein forms nuclear condensates and regulates alternative splicing. Yuan B, Zhou X, Suzuki K, Ramos-Mandujano G, Wang M, Tehseen M, Cortes-Medina LV, Moresco JJ, Dunn S, Hernandez-Benitez R, Hishida T, Kim NY, Andijani MM, Bi C, Ku M, Takahashi Y, Xu J, Qiu J, Huang L, Benner C, Aizawa E, Qu J, Liu GH, Li Z, Yi F, Ghosheh Y, Shao C, Shokhirev M, Comoli P, Frassoni F, Yates JR 3rd, Fu XD, Esteban CR, Hamdan S, Izpisua Belmonte JC, Li M. Nat Commun. 2022 Jun 25;13(1):3646. doi: 10.1038/s41467-022-31220-8. PubMed
A degradative to secretory autophagy switch mediates mitochondria clearance in the absence of the mATG8-conjugation machinery. Tan HWS, Lu G, Dong H, Cho YL, Natalia A, Wang L, Chan C, Kappei D, Taneja R, Ling SC, Shao H, Tsai SY, Ding WX, Shen HM. Nat Commun. 2022 Jun 28;13(1):3720. doi: 10.1038/s41467-022-31213-7. PubMed
Lamin B2 contributes to the proliferation of bladder cancer cells via activating the expression of cell division cycleassociated protein 3. Ji J, Li H, Chen J, Wang W. Int J Mol Med. 2022 Sep;50(3). pii: 111. doi: 10.3892/ijmm.2022.5168. Epub 2022 Jul 1. PubMed
Computational design of an apoptogenic protein that binds BCL-xL and MCL-1 simultaneously and potently. Kim S, Park HS, Oh BH. Comput Struct Biotechnol J. 2022 Jun 14;20:3019-3029. doi: 10.1016/j.csbj.2022.06.021. eCollection 2022. PubMed
Process Development for Adoptive Cell Therapy in Academia: A Pipeline for Clinical-Scale Manufacturing of Multiple TCR-T Cell Products. Silva DN, Chrobok M, Rovesti G, Healy K, Wagner AK, Maravelia P, Gatto F, Mazza M, Mazzotti L, Lohmann V, Sallberg Chen M, Sallberg M, Buggert M, Pasetto A. Front Immunol. 2022 Jun 16;13:896242. doi: 10.3389/fimmu.2022.896242. eCollection 2022. PubMed
Targeting colorectal cancer with small-molecule inhibitors of ALDH1B1. Feng Z, Hom ME, Bearrood TE, Rosenthal ZC, Fernandez D, Ondrus AE, Gu Y, McCormick AK, Tomaske MG, Marshall CR, Kline T, Chen CH, Mochly-Rosen D, Kuo CJ, Chen JK. Nat Chem Biol. 2022 Jul 4. pii: 10.1038/s41589-022-01048-w. doi: 10.1038/s41589-022-01048-w. PubMed
Genome-Wide CRISPR Screening Identifies DCK and CCNL1 as Genes That Contribute to Gemcitabine Resistance in Pancreatic Cancer. Yang H, Liu B, Liu D, Yang Z, Zhang S, Xu P, Xing Y, Kutschick I, Pfeffer S, Britzen-Laurent N, Grutzmann R, Pilarsky C. Cancers (Basel). 2022 Jun 27;14(13). pii: cancers14133152. doi: 10.3390/cancers14133152. PubMed
Discovery of Small Molecule KCC2 Potentiators Which Attenuate In Vitro Seizure-Like Activity in Cultured Neurons. Prael Iii FJ, Kim K, Du Y, Spitznagel BD, Sulikowski GA, Delpire E, Weaver CD. Front Cell Dev Biol. 2022 Jun 24;10:912812. doi: 10.3389/fcell.2022.912812. eCollection 2022. PubMed
Decline of humoral immune responses after natural SARS-CoV-2 infection can be efficiently reversed by vaccination. Oktelik FB, Yilmaz V, Gelmez MY, Akdeniz N, Pamukcu C, Sutlu T, Kose M, Tuzun E, Deniz G. Can J Microbiol. 2022 Aug 1;68(8):543-550. doi: 10.1139/cjm-2022-0003. Epub 2022 Jul 19. PubMed
"Endothelial Antibody Factory" at the Blood Brain Barrier: Novel Approach to Therapy of Neurodegenerative Diseases. Thinard R, Farkas AE, Halasa M, Chevalier M, Brodaczewska K, Majewska A, Zdanowski R, Paprocka M, Rossowska J, Duc LT, Greferath R, Krizbai I, Van Leuven F, Kieda C, Nicolau C. Pharmaceutics. 2022 Jul 6;14(7):1418. doi: 10.3390/pharmaceutics14071418. PubMed
DNA-Vaccine-Induced Immune Response Correlates with Lower Viral SARS-CoV-2 Titers in a Ferret Model. Compagnone M, Pinto E, Salvatori E, Lione L, Conforti A, Marchese S, Rava M, Ryan K, Hall Y, Rayner E, Salguero FJ, Paterson J, Iannacone M, De Francesco R, Aurisicchio L, Palombo F. Vaccines (Basel). 2022 Jul 25;10(8):1178. doi: 10.3390/vaccines10081178. PubMed
A CRISPR-Cas12a-based diagnostic method for multiple genotypes of severe fever with thrombocytopenia syndrome virus. Park BJ, Yoo JR, Heo ST, Kim M, Lee KH, Song YJ. PLoS Negl Trop Dis. 2022 Aug 2;16(8):e0010666. doi: 10.1371/journal.pntd.0010666. eCollection 2022 Aug. PubMed
FOXL2 and FOXA1 cooperatively assemble on the TP53 promoter in alternative dimer configurations. Choi Y, Luo Y, Lee S, Jin H, Yoon HJ, Hahn Y, Bae J, Lee HH. Nucleic Acids Res. 2022 Aug 26;50(15):8929-8946. doi: 10.1093/nar/gkac673. PubMed
Nucleotide imbalance decouples cell growth from cell proliferation. Diehl FF, Miettinen TP, Elbashir R, Nabel CS, Darnell AM, Do BT, Manalis SR, Lewis CA, Vander Heiden MG. Nat Cell Biol. 2022 Aug;24(8):1252-1264. doi: 10.1038/s41556-022-00965-1. Epub 2022 Aug 4. PubMed
Afadin couples RAS GTPases to the polarity rheostat Scribble. Goudreault M, Gagne V, Jo CH, Singh S, Killoran RC, Gingras AC, Smith MJ. Nat Commun. 2022 Aug 5;13(1):4562. doi: 10.1038/s41467-022-32335-8. PubMed
Prolonged FOS activity disrupts a global myogenic transcriptional program by altering 3D chromatin architecture in primary muscle progenitor cells. Barutcu AR, Elizalde G, Gonzalez AE, Soni K, Rinn JL, Wagers AJ, Almada AE. Skelet Muscle. 2022 Aug 15;12(1):20. doi: 10.1186/s13395-022-00303-x. PubMed
Shared and Distinctive Neighborhoods of Emerin and Lamin B Receptor Revealed by Proximity Labeling and Quantitative Proteomics. Cheng LC, Zhang X, Abhinav K, Nguyen JA, Baboo S, Martinez-Bartolome S, Branon TC, Ting AY, Loose E, Yates JR 3rd, Gerace L. J Proteome Res. 2022 Sep 2;21(9):2197-2210. doi: 10.1021/acs.jproteome.2c00281. Epub 2022 Aug 16. PubMed

Associated Plasmids

Overexpression of mir-135b and mir-210 in mesenchymal stromal cells for the enrichment of extracellular vesicles with angiogenic factors. Vieira JMF, Zamproni LN, Wendt CHC, Rocha de Miranda K, Lindoso RS, Won Han S. PLoS One. 2022 Aug 16;17(8):e0272962. doi: 10.1371/journal.pone.0272962. eCollection 2022. PubMed
BNIP-2 Activation of Cellular Contractility Inactivates YAP for H9c2 Cardiomyoblast Differentiation. Wong DCP, Xiao J, Chew TW, Pan M, Lee CJM, Ang JW, Yow I, Thivakar T, Ackers-Johnson M, Lee NJW, Foo RS, Kanchanawong P, Low BC. Adv Sci (Weinh). 2022 Nov;9(31):e2202834. doi: 10.1002/advs.202202834. Epub 2022 Aug 17. PubMed
Post-gastrulation synthetic embryos generated ex utero from mouse naive ESCs. Tarazi S, Aguilera-Castrejon A, Joubran C, Ghanem N, Ashouokhi S, Roncato F, Wildschutz E, Haddad M, Oldak B, Gomez-Cesar E, Livnat N, Viukov S, Lokshtanov D, Naveh-Tassa S, Rose M, Hanna S, Raanan C, Brenner O, Kedmi M, Keren-Shaul H, Lapidot T, Maza I, Novershtern N, Hanna JH. Cell. 2022 Sep 1;185(18):3290-3306.e25. doi: 10.1016/j.cell.2022.07.028. Epub 2022 Aug 1. PubMed
Lysosome exocytosis is required for mitosis in mammalian cells. Nugues C, Rajamanoharan D, Burgoyne RD, Haynes LP, Helassa N. Biochem Biophys Res Commun. 2022 Oct 20;626:211-219. doi: 10.1016/j.bbrc.2022.08.024. Epub 2022 Aug 16. PubMed
Generation of an Immortalized Human Adipose-Derived Mesenchymal Stromal Cell Line Suitable for Wound Healing Therapy. Iacomi DM, Rosca AM, Tutuianu R, Neagu TP, Pruna V, Simionescu M, Titorencu I. Int J Mol Sci. 2022 Aug 10;23(16):8925. doi: 10.3390/ijms23168925. PubMed
Synthesis and Assessment of the In Vitro and Ex Vivo Activity of Salicylate Synthase (Mbti) Inhibitors as New Candidates for the Treatment of Mycobacterial Infections. Mori M, Stelitano G, Griego A, Chiarelli LR, Cazzaniga G, Gelain A, Pini E, Camera M, Canzano P, Fumagalli A, Scarpa E, Cordiglieri C, Rizzello L, Villa S, Meneghetti F. Pharmaceuticals (Basel). 2022 Aug 11;15(8):992. doi: 10.3390/ph15080992. PubMed
LncRNA MILIP links YBX1 to translational activation of Snai1 and promotes metastasis in clear cell renal cell carcinoma. Wang Y, Feng YC, Gan Y, Teng L, Wang L, La T, Wang P, Gu Y, Yan L, Li N, Zhang L, Wang L, Thorne RF, Zhang XD, Cao H, Shao FM. J Exp Clin Cancer Res. 2022 Aug 26;41(1):260. doi: 10.1186/s13046-022-02452-9. PubMed
Protocol for viral vector-mediated measurement of transcription factor activity of mouse brain. Yamamoto H, Abe K. STAR Protoc. 2022 Aug 18;3(3):101633. doi: 10.1016/j.xpro.2022.101633. eCollection 2022 Sep 16. PubMed
The histone methyltransferase SETD2 negatively regulates cell size. Molenaar TM, Malik M, Silva J, Liu NQ, Haarhuis JHI, Ambrosi C, Kwesi-Maliepaard EM, van Welsem T, Baubec T, Faller WJ, van Leeuwen F. J Cell Sci. 2022 Oct 1;135(19):jcs259856. doi: 10.1242/jcs.259856. Epub 2022 Oct 6. PubMed
Elevation of effective p53 expression sensitizes wild-type p53 breast cancer cells to CDK7 inhibitor THZ1. Wang Y, Zhang Z, Mi X, Li M, Huang D, Song T, Qi X, Yang M. Cell Commun Signal. 2022 Sep 5;20(1):96. doi: 10.1186/s12964-022-00837-z. PubMed
Targeting histone methylation to reprogram the transcriptional state that drives survival of drug-tolerant myeloid leukemia persisters. van Gils N, Verhagen HJMP, Broux M, Martianez T, Denkers F, Vermue E, Rutten A, Csikos T, Demeyer S, Cil M, Al M, Cools J, Janssen JJWM, Ossenkoppele GJ, Menezes RX, Smit L. iScience. 2022 Aug 25;25(9):105013. doi: 10.1016/j.isci.2022.105013. eCollection 2022 Sep 16. PubMed
Assessment of T Cell Receptor Complex Expression Kinetics in Natural Killer Cells. Rasul KH, Hussain A, Reilly H, Karvouni M, Dahlberg CIM, Al-Attar MS, Wagner AK, Alici E, Mohammad DK. Curr Issues Mol Biol. 2022 Aug 25;44(9):3859-3871. doi: 10.3390/cimb44090265. PubMed
Memory CD8(+) T cell diversity and B cell responses correlate with protection against SARS-CoV-2 following mRNA vaccination. Brasu N, Elia I, Russo V, Montacchiesi G, Stabile SA, De Intinis C, Fesi F, Gizzi K, Macagno M, Montone M, Mussolin B, Grifoni A, Faravelli S, Marchese S, Forneris F, De Francesco R, Sette A, Barnaba V, Sottile A, Sapino A, Pace L. Nat Immunol. 2022 Oct;23(10):1445-1456. doi: 10.1038/s41590-022-01313-z. Epub 2022 Sep 22. PubMed
UBE2T promotes glioblastoma malignancy through ubiquitination-mediated degradation of RPL6. Tao X, Wu X, Zhou P, Yu X, Zhao C, Peng X, Zhang K, Shen L, Peng J, Yang L. Cancer Sci. 2023 Feb;114(2):521-532. doi: 10.1111/cas.15604. Epub 2022 Oct 14. PubMed
Spatiotemporal dynamics of membrane surface charge regulates cell polarity and migration. Banerjee T, Biswas D, Pal DS, Miao Y, Iglesias PA, Devreotes PN. Nat Cell Biol. 2022 Oct;24(10):1499-1515. doi: 10.1038/s41556-022-00997-7. Epub 2022 Oct 6. PubMed

Associated Plasmids

Thermal-exchange HLA-E multimers reveal specificity in HLA-E and NKG2A/CD94 complex interactions. Ruibal P, Derksen I, van Wolfswinkel M, Voogd L, Franken KLMC, El Hebieshy AF, van Hall T, Schoufour TAW, Wijdeven RH, Ottenhoff THM, Scheeren FA, Joosten SA. Immunology. 2023 Mar;168(3):526-537. doi: 10.1111/imm.13591. Epub 2022 Oct 20. PubMed
Angiotensin II receptor type 1 blockade regulates Klotho expression to induce TSC2-deficient cell death. Shrestha S, Adib E, Imani J, Aguiar DJ, Lamattina AM, Tassew DD, Henske EP, Perrella MA, Priolo C, El-Chemaly S. J Biol Chem. 2022 Nov;298(11):102580. doi: 10.1016/j.jbc.2022.102580. Epub 2022 Oct 8. PubMed
Combining NGN2 programming and dopaminergic patterning for a rapid and efficient generation of hiPSC-derived midbrain neurons. Sheta R, Teixeira M, Idi W, Pierre M, de Rus Jacquet A, Emond V, Zorca CE, Vanderperre B, Durcan TM, Fon EA, Calon F, Chahine M, Oueslati A. Sci Rep. 2022 Oct 13;12(1):17176. doi: 10.1038/s41598-022-22158-4. PubMed
Spatial epitope barcoding reveals clonal tumor patch behaviors. Rovira-Clave X, Drainas AP, Jiang S, Bai Y, Baron M, Zhu B, Dallas AE, Lee MC, Chu TP, Holzem A, Ayyagari R, Bhattacharya D, McCaffrey EF, Greenwald NF, Markovic M, Coles GL, Angelo M, Bassik MC, Sage J, Nolan GP. Cancer Cell. 2022 Nov 14;40(11):1423-1439.e11. doi: 10.1016/j.ccell.2022.09.014. Epub 2022 Oct 13. PubMed

Associated Plasmids

Caspase-Mediated Regulation and Cellular Heterogeneity of the cGAS/STING Pathway in Kaposi's Sarcoma-Associated Herpesvirus Infection. Tabtieng T, Lent RC, Kaku M, Monago Sanchez A, Gaglia MM. mBio. 2022 Dec 20;13(6):e0244622. doi: 10.1128/mbio.02446-22. Epub 2022 Oct 18. PubMed
CASK loss of function differentially regulates neuronal maturation and synaptic function in human induced cortical excitatory neurons. McSweeney D, Gabriel R, Jin K, Pang ZP, Aronow B, Pak C. iScience. 2022 Sep 23;25(10):105187. doi: 10.1016/j.isci.2022.105187. eCollection 2022 Oct 21. PubMed
The AhR-SRC axis as a therapeutic vulnerability in BRAFi-resistant melanoma. Paris A, Tardif N, Baietti FM, Berra C, Leclair HM, Leucci E, Galibert MD, Corre S. EMBO Mol Med. 2022 Dec 7;14(12):e15677. doi: 10.15252/emmm.202215677. Epub 2022 Oct 28. PubMed
Thioredoxin-interacting protein-activated intracellular potassium deprivation mediates the anti-tumour effect of a novel histone acetylation inhibitor HL23, a fangchinoline derivative, in human hepatocellular carcinoma. Lu Y, Liu Y, Lan J, Chan YT, Feng Z, Huang L, Wang N, Pan W, Feng Y. J Adv Res. 2022 Nov 9:S2090-1232(22)00246-6. doi: 10.1016/j.jare.2022.10.017. PubMed
The MASTL/PP2A cell cycle kinase-phosphatase module restrains PI3K-Akt activity in an mTORC1-dependent manner. Sanz-Castillo B, Hurtado B, Vara-Ciruelos D, El Bakkali A, Hermida D, Salvador-Barbero B, Martinez-Alonso D, Gonzalez-Martinez J, Santiveri C, Campos-Olivas R, Ximenez-Embun P, Munoz J, Alvarez-Fernandez M, Malumbres M. EMBO J. 2023 Jan 16;42(2):e110833. doi: 10.15252/embj.2022110833. Epub 2022 Nov 10. PubMed
Cell-intrinsic differences between human airway epithelial cells from children and adults. Maughan EF, Hynds RE, Pennycuick A, Nigro E, Gowers KHC, Denais C, Gomez-Lopez S, Lazarus KA, Orr JC, Pearce DR, Clarke SE, Lee DDH, Woodall MNJ, Masonou T, Case KM, Teixeira VH, Hartley BE, Hewitt RJ, Al Yaghchi C, Sandhu GS, Birchall MA, O'Callaghan C, Smith CM, De Coppi P, Butler CR, Janes SM. iScience. 2022 Oct 20;25(11):105409. doi: 10.1016/j.isci.2022.105409. eCollection 2022 Nov 18. PubMed
A genome-wide CRISPR screen implicates plasma membrane asymmetry in exogenous C6-ceramide toxicity. Morris SNS, Deol KK, Lange M, Olzmann JA. Biol Open. 2022 Dec 15;11(12):bio059695. doi: 10.1242/bio.059695. Epub 2022 Dec 19. PubMed
Systematic generation and imaging of tandem repeats reveal base-pairing properties that promote RNA aggregation. Isiktas AU, Eshov A, Yang S, Guo JU. Cell Rep Methods. 2022 Nov 9;2(11):100334. doi: 10.1016/j.crmeth.2022.100334. eCollection 2022 Nov 21. PubMed
Acute COG complex inactivation unveiled its immediate impact on Golgi and illuminated the nature of intra-Golgi recycling vesicles. Sumya FT, Pokrovskaya ID, D'Souza Z, Lupashin VV. Traffic. 2023 Feb;24(2):52-75. doi: 10.1111/tra.12876. Epub 2022 Dec 15. PubMed
Hyperactivation of p53 using CRISPRa kills human papillomavirus-driven cervical cancer cells. Idres YM, Lai AJ, McMillan NAJ, Idris A. Virus Genes. 2023 Apr;59(2):312-316. doi: 10.1007/s11262-022-01960-2. Epub 2022 Dec 6. PubMed
Suppression of PD-L1 release from small extracellular vesicles promotes systemic anti-tumor immunity by targeting ORAI1 calcium channels. Chen X, Li J, Zhang R, Zhang Y, Wang X, Leung EL, Ma L, Wong VKW, Liu L, Neher E, Yu H. J Extracell Vesicles. 2022 Dec;11(12):e12279. doi: 10.1002/jev2.12279. PubMed
Transcription Factor-Forced Astrocytic Differentiation Impairs Human Glioblastoma Growth In Vitro and In Vivo. Trovato F, Stefani FR, Li J, Zetterdahl OG, Canals I, Ahlenius H, Bengzon J. Mol Cancer Ther. 2023 Feb 1;22(2):274-286. doi: 10.1158/1535-7163.MCT-21-0903. PubMed
A fast-growing dengue virus mutant reveals a dual role of STING in response to infection. Ng WC, Kwek SS, Sun B, Yousefi M, Ong EZ, Tan HC, Puschnik AS, Chan KR, Ooi YS, Ooi EE. Open Biol. 2022 Dec;12(12):220227. doi: 10.1098/rsob.220227. Epub 2022 Dec 14. PubMed
Tumor necrosis factor is a necroptosis-associated alarmin. Pinci F, Gaidt MM, Jung C, Nagl D, Kuut G, Hornung V. Front Immunol. 2022 Dec 12;13:1074440. doi: 10.3389/fimmu.2022.1074440. eCollection 2022. PubMed
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Associated Plasmids

Inhibiting the Deubiquitinase UCHL1 Reduces SARS-CoV-2 Viral Uptake by ACE2. Bednash JS, Johns F, Farkas D, Elhance A, Adair J, Cress K, Yount JS, Kenney AD, Londino JD, Mallampalli RK. Am J Respir Cell Mol Biol. 2023 May;68(5):566-576. doi: 10.1165/rcmb.2022-0331OC. PubMed