pCMV-VSV-G Citations (752)
Originally described in: Lentivirus-delivered stable gene silencing by RNAi in primary cells.Stewart SA, Dykxhoorn DM, Palliser D, Mizuno H, Yu EY, An DS, Sabatini DM, Chen IS, Hahn WC, Sharp PA, Weinberg RA, Novina CD RNA 2003 Apr;9(4):493-501. PubMed Journal
Articles Citing pCMV-VSV-G
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| Coactivation of janus tyrosine kinase (Jak)1 positively modulates prolactin-Jak2 signaling in breast cancer: recruitment of ERK and signal transducer and activator of transcription (Stat)3 and enhancement of Akt and Stat5a/b pathways. Neilson LM, Zhu J, Xie J, Malabarba MG, Sakamoto K, Wagner KU, Kirken RA, Rui H. Mol Endocrinol. 2007 Sep . 21(9):2218-32. PubMed |
| Role of GLI2 transcription factor in growth and tumorigenicity of prostate cells. Thiyagarajan S, Bhatia N, Reagan-Shaw S, Cozma D, Thomas-Tikhonenko A, Ahmad N, Spiegelman VS. Cancer Res. 2007 Nov 15;67(22):10642-6. PubMed |
| mTORC2 activity is elevated in gliomas and promotes growth and cell motility via overexpression of rictor. Masri J, Bernath A, Martin J, Jo OD, Vartanian R, Funk A, Gera J. Cancer Res. 2007 Dec 15. 67(24):11712-20. PubMed |
| Generation of human-induced pluripotent stem cells. Park IH, Lerou PH, Zhao R, Huo H, Daley GQ. Nat Protoc. 2008 . 3(7):1180-6. PubMed |
| XRCC1 protects against the lethality of induced oxidative DNA damage in nondividing neural cells. Kulkarni A, McNeill DR, Gleichmann M, Mattson MP, Wilson DM 3rd. Nucleic Acids Res. 2008 Sep;36(15):5111-21. doi: 10.1093/nar/gkn480. Epub 2008 Aug 5. PubMed |
| A myelopoiesis-associated regulatory intergenic noncoding RNA transcript within the human HOXA cluster. Zhang X, Lian Z, Padden C, Gerstein MB, Rozowsky J, Snyder M, Gingeras TR, Kapranov P, Weissman SM, Newburger PE. Blood. 2009 Mar 12;113(11):2526-34. doi: 10.1182/blood-2008-06-162164. Epub 2009 Jan 14. PubMed |
| Human iPS cell derivation/reprogramming. Park IH, Daley GQ. Curr Protoc Stem Cell Biol. 2009 Jan . Chapter 4():Unit 4A.1. PubMed |
| The transcription of FOXO genes is stimulated by FOXO3 and repressed by growth factors. Essaghir A, Dif N, Marbehant CY, Coffer PJ, Demoulin JB. J Biol Chem. 2009 Apr 17;284(16):10334-42. doi: 10.1074/jbc.M808848200. Epub 2009 Feb 24. PubMed |
| Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus (KSHV) upregulates survivin expression in KSHV-Associated B-lymphoma cells and contributes to their proliferation. Lu J, Verma SC, Murakami M, Cai Q, Kumar P, Xiao B, Robertson ES. J Virol. 2009 Jul;83(14):7129-41. doi: 10.1128/JVI.00397-09. Epub 2009 May 13. PubMed |
| Site-specific mTOR phosphorylation promotes mTORC1-mediated signaling and cell growth. Acosta-Jaquez HA, Keller JA, Foster KG, Ekim B, Soliman GA, Ballif BA, Fingar DC. Mol Cell Biol. 2009 Jun 1. ():. PubMed |
| Conditional mouse lung cancer models using adenoviral or lentiviral delivery of Cre recombinase. DuPage M, Dooley AL, Jacks T. Nat Protoc. 2009;4(7):1064-72. doi: 10.1038/nprot.2009.95. Epub 2009 Jun 25. PubMed |
| Enhanced generation of induced pluripotent stem cells from a subpopulation of human fibroblasts. Byrne JA, Nguyen HN, Reijo Pera RA. PLoS One. 2009 Sep 23;4(9):e7118. doi: 10.1371/journal.pone.0007118. PubMed |
| TAPP2 links phosphoinositide 3-kinase signaling to B-cell adhesion through interaction with the cytoskeletal protein utrophin: expression of a novel cell adhesion-promoting complex in B-cell leukemia. Costantini JL, Cheung SM, Hou S, Li H, Kung SK, Johnston JB, Wilkins JA, Gibson SB, Marshall AJ. Blood. 2009 Nov 19;114(21):4703-12. doi: 10.1182/blood-2009-03-213058. Epub 2009 Sep 28. PubMed |
| Generation of induced pluripotent stem cells from neural stem cells. Kim JB, Zaehres H, Arauzo-Bravo MJ, Scholer HR. Nat Protoc. 2009;4(10):1464-70. doi: 10.1038/nprot.2009.173. Epub 2009 Sep 17. PubMed |
| Mouse and human induced pluripotent stem cells as a source for multipotent Isl1+ cardiovascular progenitors. Moretti A, Bellin M, Jung CB, Thies TM, Takashima Y, Bernshausen A, Schiemann M, Fischer S, Moosmang S, Smith AG, Lam JT, Laugwitz KL. FASEB J. 2010 Mar;24(3):700-11. doi: 10.1096/fj.09-139477. Epub 2009 Oct 22. PubMed |
| Functional analysis of the Cdk7.cyclin H.Mat1 complex in mouse embryonic stem cells and embryos. Patel SA, Simon MC. J Biol Chem. 2010 May 14;285(20):15587-98. doi: 10.1074/jbc.M109.081687. Epub 2010 Mar 15. PubMed |
| Transmembrane protein 147 (TMEM147) is a novel component of the Nicalin-NOMO protein complex. Dettmer U, Kuhn PH, Abou-Ajram C, Lichtenthaler SF, Kruger M, Kremmer E, Haass C, Haffner C. J Biol Chem. 2010 Aug 20;285(34):26174-81. doi: 10.1074/jbc.M110.132548. Epub 2010 Jun 10. PubMed |
| Exploration of self-renewal and pluripotency in ES cells using RNAi. Schaniel C, Lee DF, Lemischka IR. Methods Enzymol. 2010;477:351-65. doi: 10.1016/S0076-6879(10)77018-X. PubMed |
| PTP1B suppresses prolactin activation of Stat5 in breast cancer cells. Johnson KJ, Peck AR, Liu C, Tran TH, Utama FE, Sjolund AB, Schaber JD, Witkiewicz AK, Rui H. Am J Pathol. 2010 Dec;177(6):2971-83. doi: 10.2353/ajpath.2010.090399. Epub 2010 Oct 15. PubMed |
Large intergenic non-coding RNA-RoR modulates reprogramming of human induced pluripotent stem cells.
Loewer S, Cabili MN, Guttman M, Loh YH, Thomas K, Park IH, Garber M, Curran M, Onder T, Agarwal S, Manos PD, Datta S, Lander ES, Schlaeger TM, Daley GQ, Rinn JL.
Nat Genet. 2010 Dec;42(12):1113-7. Epub 2010 Nov 7.
PubMed
Associated Plasmids |
| Generation of Pig iPS Cells: A Model for Cell Therapy. Montserrat N, Bahima EG, Batlle L, Häfner S, Rodrigues AM, González F, Belmonte JC. J Cardiovasc Transl Res. 2010 Nov 19. ():. PubMed |
| Feeder-dependent and feeder-independent iPS cell derivation from human and mouse adipose stem cells. Sugii S, Kida Y, Berggren WT, Evans RM. Nat Protoc. 2011 Mar;6(3):346-58. doi: 10.1038/nprot.2010.199. Epub 2011 Feb 24. PubMed |
| Differentiation and neuro-protective properties of immortalized human tooth germ stem cells. Yalvac ME, Yilmaz A, Mercan D, Aydin S, Dogan A, Arslan A, Demir Z, Salafutdinov II, Shafigullina AK, Sahin F, Rizvanov AA, Palotas A. Neurochem Res. 2011 Dec;36(12):2227-35. doi: 10.1007/s11064-011-0546-7. Epub 2011 Jul 22. PubMed |
| Checkpoint kinase 1 prevents cell cycle exit linked to terminal cell differentiation. Ullah Z, de Renty C, DePamphilis ML. Mol Cell Biol. 2011 Oct;31(19):4129-43. doi: 10.1128/MCB.05723-11. Epub 2011 Jul 26. PubMed |
| Growth differentiation factor 15 (GDF15)-mediated HER2 phosphorylation reduces trastuzumab sensitivity of HER2-overexpressing breast cancer cells. Joshi JP, Brown NE, Griner SE, Nahta R. Biochem Pharmacol. 2011 Nov 1;82(9):1090-9. doi: 10.1016/j.bcp.2011.07.082. Epub 2011 Jul 23. PubMed |
| Quantitative fluorescence imaging of protein diffusion and interaction in living cells. Capoulade J, Wachsmuth M, Hufnagel L, Knop M. Nat Biotechnol. 2011 Aug 7;29(9):835-9. doi: 10.1038/nbt.1928. PubMed |
| Generation of induced pluripotent stem cell lines from human fibroblasts via retroviral gene transfer. Miller JD, Schlaeger TM. Methods Mol Biol. 2011;767:55-65. doi: 10.1007/978-1-61779-201-4_5. PubMed |
| GADD45A protein plays an essential role in active DNA demethylation during terminal osteogenic differentiation of adipose-derived mesenchymal stem cells. Zhang RP, Shao JZ, Xiang LX. J Biol Chem. 2011 Nov 25;286(47):41083-94. doi: 10.1074/jbc.M111.258715. Epub 2011 Sep 14. PubMed |
| A Trio-RhoA-Shroom3 pathway is required for apical constriction and epithelial invagination. Plageman TF Jr, Chauhan BK, Yang C, Jaudon F, Shang X, Zheng Y, Lou M, Debant A, Hildebrand JD, Lang RA. Development. 2011 Dec;138(23):5177-88. doi: 10.1242/dev.067868. Epub 2011 Oct 26. PubMed |
| Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma. Landreville S, Agapova OA, Matatall KA, Kneass ZT, Onken MD, Lee RS, Bowcock AM, Harbour JW. Clin Cancer Res. 2012 Jan 15;18(2):408-16. doi: 10.1158/1078-0432.CCR-11-0946. Epub 2011 Oct 28. PubMed |
| Quantification of HIV-based lentiviral vectors: influence of several cell type parameters on vector infectivity. Gay V, Moreau K, Hong SS, Ronfort C. Arch Virol. 2012 Feb;157(2):217-23. doi: 10.1007/s00705-011-1150-5. Epub 2011 Oct 29. PubMed |
| FGF signalling inhibits neural induction in human embryonic stem cells. Greber B, Coulon P, Zhang M, Moritz S, Frank S, Muller-Molina AJ, Arauzo-Bravo MJ, Han DW, Pape HC, Scholer HR. EMBO J. 2011 Nov 15;30(24):4874-84. doi: 10.1038/emboj.2011.407. PubMed |
| Ran is a potential therapeutic target for cancer cells with molecular changes associated with activation of the PI3K/Akt/mTORC1 and Ras/MEK/ERK pathways. Yuen HF, Chan KK, Grills C, Murray JT, Platt-Higgins A, Eldin OS, O'Byrne K, Janne P, Fennell DA, Johnston PG, Rudland PS, El-Tanani M. Clin Cancer Res. 2012 Jan 15;18(2):380-91. doi: 10.1158/1078-0432.CCR-11-2035. Epub 2011 Nov 16. PubMed |
| Synthesis of cytochrome C oxidase 2: a p53-dependent metabolic regulator that promotes respiratory function and protects glioma and colon cancer cells from hypoxia-induced cell death. Wanka C, Brucker DP, Bahr O, Ronellenfitsch M, Weller M, Steinbach JP, Rieger J. Oncogene. 2012 Aug 16;31(33):3764-76. doi: 10.1038/onc.2011.530. Epub 2011 Nov 28. PubMed |
| Epstein-Barr virus nuclear antigen 3C stabilizes Gemin3 to block p53-mediated apoptosis. Cai Q, Guo Y, Xiao B, Banerjee S, Saha A, Lu J, Glisovic T, Robertson ES. PLoS Pathog. 2011 Dec;7(12):e1002418. doi: 10.1371/journal.ppat.1002418. Epub 2011 Dec 8. PubMed |
| Reprogramming of mouse, rat, pig, and human fibroblasts into iPS cells. Rajarajan K, Engels MC, Wu SM. Curr Protoc Mol Biol. 2012 Jan;Chapter 23:Unit 23.15.. doi: 10.1002/0471142727.mb2315s97. PubMed |
| Potassium channel mutant KCNJ5 T158A expression in HAC-15 cells increases aldosterone synthesis. Oki K, Plonczynski MW, Luis Lam M, Gomez-Sanchez EP, Gomez-Sanchez CE. Endocrinology. 2012 Apr;153(4):1774-82. doi: 10.1210/en.2011-1733. Epub 2012 Feb 7. PubMed |
| Peroxisome proliferator-activated receptor beta/delta induces myogenesis by modulating myostatin activity. Bonala S, Lokireddy S, Arigela H, Teng S, Wahli W, Sharma M, McFarlane C, Kambadur R. J Biol Chem. 2012 Apr 13;287(16):12935-51. doi: 10.1074/jbc.M111.319145. Epub 2012 Feb 23. PubMed |
| Derivation of mesenchymal stem cells from human induced pluripotent stem cells cultured on synthetic substrates. Villa-Diaz LG, Brown SE, Liu Y, Ross AM, Lahann J, Parent JM, Krebsbach PH. Stem Cells. 2012 Jun;30(6):1174-81. doi: 10.1002/stem.1084. PubMed |
| Combining competition assays with genetic complementation strategies to dissect mouse embryonic stem cell self-renewal and pluripotency. Lee DF, Su J, Sevilla A, Gingold J, Schaniel C, Lemischka IR. Nat Protoc. 2012 Mar 22;7(4):729-48. doi: 10.1038/nprot.2012.018. PubMed |
| Cockayne syndrome group B protein prevents the accumulation of damaged mitochondria by promoting mitochondrial autophagy. Scheibye-Knudsen M, Ramamoorthy M, Sykora P, Maynard S, Lin PC, Minor RK, Wilson DM 3rd, Cooper M, Spencer R, de Cabo R, Croteau DL, Bohr VA. J Exp Med. 2012 Apr 9;209(4):855-69. doi: 10.1084/jem.20111721. Epub 2012 Apr 2. PubMed |
| Excision of a viral reprogramming cassette by delivery of synthetic Cre mRNA. Loh YH, Yang JC, De Los Angeles A, Guo C, Cherry A, Rossi DJ, Park IH, Daley GQ. Curr Protoc Stem Cell Biol. 2012;Chapter 4:Unit4A.5. doi: 10.1002/9780470151808.sc04a05s21. PubMed |
| Maternal obesity downregulates microRNA let-7g expression, a possible mechanism for enhanced adipogenesis during ovine fetal skeletal muscle development. Yan X, Huang Y, Zhao JX, Rogers CJ, Zhu MJ, Ford SP, Nathanielsz PW, Du M. Int J Obes (Lond). 2013 Apr;37(4):568-75. doi: 10.1038/ijo.2012.69. Epub 2012 May 22. PubMed |
| MARCKS regulates growth and radiation sensitivity and is a novel prognostic factor for glioma. Jarboe JS, Anderson JC, Duarte CW, Mehta T, Nowsheen S, Hicks PH, Whitley AC, Rohrbach TD, McCubrey RO, Chiu S, Burleson TM, Bonner JA, Gillespie GY, Yang ES, Willey CD. Clin Cancer Res. 2012 Jun 1;18(11):3030-41. doi: 10.1158/1078-0432.CCR-11-3091. Epub 2012 May 22. PubMed |
| Human TSC-associated renal angiomyolipoma cells are hypersensitive to ER stress. Siroky BJ, Yin H, Babcock JT, Lu L, Hellmann AR, Dixon BP, Quilliam LA, Bissler JJ. Am J Physiol Renal Physiol. 2012 Sep 15;303(6):F831-44. doi: 10.1152/ajprenal.00441.2011. Epub 2012 Jul 11. PubMed |
| The extent of degeneration of cruciate ligament is associated with chondrogenic differentiation in patients with osteoarthritis of the knee. Kumagai K, Sakai K, Kusayama Y, Akamatsu Y, Sakamaki K, Morita S, Sasaki T, Saito T, Sakai T. Osteoarthritis Cartilage. 2012 Nov;20(11):1258-67. doi: 10.1016/j.joca.2012.07.013. Epub 2012 Jul 27. PubMed |
| Small molecule-assisted, line-independent maintenance of human pluripotent stem cells in defined conditions. Frank S, Zhang M, Scholer HR, Greber B. PLoS One. 2012;7(7):e41958. doi: 10.1371/journal.pone.0041958. Epub 2012 Jul 30. PubMed |
| Codon-usage-based inhibition of HIV protein synthesis by human schlafen 11. Li M, Kao E, Gao X, Sandig H, Limmer K, Pavon-Eternod M, Jones TE, Landry S, Pan T, Weitzman MD, David M. Nature. 2012 Nov 1;491(7422):125-8. doi: 10.1038/nature11433. Epub 2012 Sep 23. PubMed |
| Defining Akt actions in muscle differentiation. Gardner S, Anguiano M, Rotwein P. Am J Physiol Cell Physiol. 2012 Dec 15;303(12):C1292-300. doi: 10.1152/ajpcell.00259.2012. Epub 2012 Oct 17. PubMed |
| Growth differentiation factor 15 stimulates rapamycin-sensitive ovarian cancer cell growth and invasion. Griner SE, Joshi JP, Nahta R. Biochem Pharmacol. 2013 Jan 1;85(1):46-58. doi: 10.1016/j.bcp.2012.10.007. Epub 2012 Oct 17. PubMed |
| Loss of NF1 expression in human endothelial cells promotes autonomous proliferation and altered vascular morphogenesis. Bajaj A, Li QF, Zheng Q, Pumiglia K. PLoS One. 2012;7(11):e49222. doi: 10.1371/journal.pone.0049222. Epub 2012 Nov 7. PubMed |
| Phytochemicals attenuating aberrant activation of beta-catenin in cancer cells. Wang D, Wise ML, Li F, Dey M. PLoS One. 2012;7(12):e50508. doi: 10.1371/journal.pone.0050508. Epub 2012 Dec 3. PubMed |
| High-mobility group box 2 (HMGB2) modulates radioresponse and is downregulated by p53 in colorectal cancer cell. Shin YJ, Kim MS, Kim MS, Lee J, Kang M, Jeong JH. Cancer Biol Ther. 2013 Mar;14(3):213-21. doi: 10.4161/cbt.23292. Epub 2012 Dec 19. PubMed |
| On-target JAK2/STAT3 inhibition slows disease progression in orthotopic xenografts of human glioblastoma brain tumor stem cells. Stechishin OD, Luchman HA, Ruan Y, Blough MD, Nguyen SA, Kelly JJ, Cairncross JG, Weiss S. Neuro Oncol. 2013 Feb;15(2):198-207. doi: 10.1093/neuonc/nos302. Epub 2012 Dec 21. PubMed |
| Gene transduction in human monocyte-derived dendritic cells using lentiviral vectors. Satoh T, Manel N. Methods Mol Biol. 2013;960:401-9. doi: 10.1007/978-1-62703-218-6_30. PubMed |
| Patient-derived models of human breast cancer: protocols for in vitro and in vivo applications in tumor biology and translational medicine. DeRose YS, Gligorich KM, Wang G, Georgelas A, Bowman P, Courdy SJ, Welm AL, Welm BE. Curr Protoc Pharmacol. 2013 Mar;Chapter 14:Unit14.23. doi: 10.1002/0471141755.ph1423s60. PubMed |
| Genetic correction of a LRRK2 mutation in human iPSCs links parkinsonian neurodegeneration to ERK-dependent changes in gene expression. Reinhardt P, Schmid B, Burbulla LF, Schondorf DC, Wagner L, Glatza M, Hoing S, Hargus G, Heck SA, Dhingra A, Wu G, Muller S, Brockmann K, Kluba T, Maisel M, Kruger R, Berg D, Tsytsyura Y, Thiel CS, Psathaki OE, Klingauf J, Kuhlmann T, Klewin M, Muller H, Gasser T, Scholer HR, Sterneckert J. Cell Stem Cell. 2013 Mar 7;12(3):354-67. doi: 10.1016/j.stem.2013.01.008. PubMed |
| Rapamycin-treated human endothelial cells preferentially activate allogeneic regulatory T cells. Wang C, Yi T, Qin L, Maldonado RA, von Andrian UH, Kulkarni S, Tellides G, Pober JS. J Clin Invest. 2013 Apr;123(4):1677-93. doi: 10.1172/JCI66204. Epub 2013 Mar 8. PubMed |
| Derivation and expansion using only small molecules of human neural progenitors for neurodegenerative disease modeling. Reinhardt P, Glatza M, Hemmer K, Tsytsyura Y, Thiel CS, Hoing S, Moritz S, Parga JA, Wagner L, Bruder JM, Wu G, Schmid B, Ropke A, Klingauf J, Schwamborn JC, Gasser T, Scholer HR, Sterneckert J. PLoS One. 2013;8(3):e59252. doi: 10.1371/journal.pone.0059252. Epub 2013 Mar 22. PubMed |
| Rap2b, a novel p53 target, regulates p53-mediated pro-survival function. Zhang X, He Y, Lee KH, Dubois W, Li Z, Wu X, Kovalchuk A, Zhang W, Huang J. Cell Cycle. 2013 Apr 15;12(8):1279-91. doi: 10.4161/cc.24364. Epub 2013 Mar 27. PubMed |
| Protein impurities from cell culture dramatically impact transduction efficiency of polymer/virus hybrid vectors. Vupputuri S, Karode S, Neely BJ, Ramsey JD. J Virol Methods. 2013 Sep;192(1-2):1-11. doi: 10.1016/j.jviromet.2013.04.007. Epub 2013 Apr 16. PubMed |
| Mammalian target of rapamycin complex 1 (mTORC1) enhances bortezomib-induced death in tuberous sclerosis complex (TSC)-null cells by a c-MYC-dependent induction of the unfolded protein response. Babcock JT, Nguyen HB, He Y, Hendricks JW, Wek RC, Quilliam LA. J Biol Chem. 2013 May 31;288(22):15687-98. doi: 10.1074/jbc.M112.431056. Epub 2013 Apr 23. PubMed |
| Lentiviral vector production, titration, and transduction of primary neurons. Ding B, Kilpatrick DL. Methods Mol Biol. 2013;1018:119-31. doi: 10.1007/978-1-62703-444-9_12. PubMed |
| The RecQ helicase RECQL5 participates in psoralen-induced interstrand cross-link repair. Ramamoorthy M, May A, Tadokoro T, Popuri V, Seidman MM, Croteau DL, Bohr VA. Carcinogenesis. 2013 Oct;34(10):2218-30. doi: 10.1093/carcin/bgt183. Epub 2013 May 28. PubMed |
| BAP1 deficiency causes loss of melanocytic cell identity in uveal melanoma. Matatall KA, Agapova OA, Onken MD, Worley LA, Bowcock AM, Harbour JW. BMC Cancer. 2013 Aug 5;13:371. doi: 10.1186/1471-2407-13-371. PubMed |
| The ING4 Binding with p53 and Induced p53 Acetylation were Attenuated by Human Papillomavirus 16 E6. Guo Y, Meng X, Wang Q, Wang Y, Shang H. PLoS One. 2013 Aug 13;8(8):e71453. doi: 10.1371/journal.pone.0071453. eCollection 2013. PubMed |
| Generation of porcine induced pluripotent stem cells and evaluation of their major histocompatibility complex protein expression in vitro. Park KM, Cha SH, Ahn C, Woo HM. Vet Res Commun. 2013 Dec;37(4):293-301. doi: 10.1007/s11259-013-9574-x. Epub 2013 Aug 23. PubMed |
| Evaluation of the molecular mechanisms of a palladium(II) saccharinate complex with terpyridine as an anticancer agent. Kacar O, Adiguzel Z, Yilmaz VT, Cetin Y, Cevatemre B, Arda N, Baykal AT, Ulukaya E, Acilan C. Anticancer Drugs. 2014 Jan;25(1):17-29. doi: 10.1097/CAD.0b013e328364c6ad. PubMed |
| Autophagy sensitivity of neuroendocrine lung tumor cells. Hong SK, Kim JH, Starenki D, Park JI. Int J Oncol. 2013 Dec;43(6):2031-8. doi: 10.3892/ijo.2013.2136. Epub 2013 Oct 11. PubMed |
| Acidosis decreases c-Myc oncogene expression in human lymphoma cells: a role for the proton-sensing G protein-coupled receptor TDAG8. Li Z, Dong L, Dean E, Yang LV. Int J Mol Sci. 2013 Oct 11;14(10):20236-55. doi: 10.3390/ijms141020236. PubMed |
| Lentiviral overexpression of miRNAs. Zollner H, Hahn SA, Maghnouj A. Methods Mol Biol. 2014;1095:177-90. doi: 10.1007/978-1-62703-703-7_15. PubMed |
| PRDM14 promotes active DNA demethylation through the ten-eleven translocation (TET)-mediated base excision repair pathway in embryonic stem cells. Okashita N, Kumaki Y, Ebi K, Nishi M, Okamoto Y, Nakayama M, Hashimoto S, Nakamura T, Sugasawa K, Kojima N, Takada T, Okano M, Seki Y. Development. 2014 Jan;141(2):269-80. doi: 10.1242/dev.099622. Epub 2013 Dec 11. PubMed |
| TGF-beta receptor type-2 expression in cancer-associated fibroblasts regulates breast cancer cell growth and survival and is a prognostic marker in pre-menopausal breast cancer. Busch S, Acar A, Magnusson Y, Gregersson P, Ryden L, Landberg G. Oncogene. 2015 Jan 2;34(1):27-38. doi: 10.1038/onc.2013.527. Epub 2013 Dec 16. PubMed |
| Automated analysis of clonal cancer cells by intravital imaging. Coffey SE, Giedt RJ, Weissleder R. Intravital. 2013 Jul;2(3). doi: 10.4161/intv.26138. PubMed |
| Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging. Gomes AP, Price NL, Ling AJ, Moslehi JJ, Montgomery MK, Rajman L, White JP, Teodoro JS, Wrann CD, Hubbard BP, Mercken EM, Palmeira CM, de Cabo R, Rolo AP, Turner N, Bell EL, Sinclair DA. Cell. 2013 Dec 19;155(7):1624-38. doi: 10.1016/j.cell.2013.11.037. PubMed |
| Gene delivery in malignant B cells using the combination of lentiviruses conjugated to anti-transferrin receptor antibodies and an immunoglobulin promoter. Leoh LS, Morizono K, Kershaw KM, Chen IS, Penichet ML, Daniels-Wells TR. J Gene Med. 2014 Jan-Feb;16(1-2):11-27. doi: 10.1002/jgm.2754. PubMed |
| Plakoglobin but not desmoplakin regulates keratinocyte cohesion via modulation of p38MAPK signaling. Spindler V, Dehner C, Hubner S, Waschke J. J Invest Dermatol. 2014 Jun;134(6):1655-64. doi: 10.1038/jid.2014.21. Epub 2014 Jan 17. PubMed |
| Myostatin induces insulin resistance via Casitas B-lineage lymphoma b (Cblb)-mediated degradation of insulin receptor substrate 1 (IRS1) protein in response to high calorie diet intake. Bonala S, Lokireddy S, McFarlane C, Patnam S, Sharma M, Kambadur R. J Biol Chem. 2014 Mar 14;289(11):7654-70. doi: 10.1074/jbc.M113.529925. Epub 2014 Jan 22. PubMed |
| Rapamycin antagonizes TNF induction of VCAM-1 on endothelial cells by inhibiting mTORC2. Wang C, Qin L, Manes TD, Kirkiles-Smith NC, Tellides G, Pober JS. J Exp Med. 2014 Mar 10;211(3):395-404. doi: 10.1084/jem.20131125. Epub 2014 Feb 10. PubMed |
| Rapid cellular phenotyping of human pluripotent stem cell-derived cardiomyocytes using a genetically encoded fluorescent voltage sensor. Leyton-Mange JS, Mills RW, Macri VS, Jang MY, Butte FN, Ellinor PT, Milan DJ. Stem Cell Reports. 2014 Feb 6;2(2):163-70. doi: 10.1016/j.stemcr.2014.01.003. eCollection 2014 Feb 11. PubMed |
| IQGAP1 binds to estrogen receptor-alpha and modulates its function. Erdemir HH, Li Z, Sacks DB. J Biol Chem. 2014 Mar 28;289(13):9100-12. doi: 10.1074/jbc.M114.553511. Epub 2014 Feb 18. PubMed |
| A differential role for CXCR4 in the regulation of normal versus malignant breast stem cell activity. Ablett MP, O'Brien CS, Sims AH, Farnie G, Clarke RB. Oncotarget. 2014 Feb 15;5(3):599-612. PubMed |
| Resistance to mTOR kinase inhibitors in lymphoma cells lacking 4EBP1. Mallya S, Fitch BA, Lee JS, So L, Janes MR, Fruman DA. PLoS One. 2014 Feb 21;9(2):e88865. doi: 10.1371/journal.pone.0088865. eCollection 2014. PubMed |
Anoctamin 6 regulates C2C12 myoblast proliferation.
Zhao P, Torcaso A, Mariano A, Xu L, Mohsin S, Zhao L, Han R.
PLoS One. 2014 Mar 24;9(3):e92749. doi: 10.1371/journal.pone.0092749. eCollection 2014.
PubMed
Associated Plasmids |
MYPT1 regulates contractility and microtubule acetylation to modulate integrin adhesions and matrix assembly.
Joo EE, Yamada KM.
Nat Commun. 2014 Mar 25;5:3510. doi: 10.1038/ncomms4510.
PubMed
Associated Plasmids |
| Regulation of fibulin-2 gene expression by integrin alpha3beta1 contributes to the invasive phenotype of transformed keratinocytes. Missan DS, Chittur SV, DiPersio CM. J Invest Dermatol. 2014 Sep;134(9):2418-27. doi: 10.1038/jid.2014.166. Epub 2014 Apr 2. PubMed |
| Hypoxia enhances the antiglioma cytotoxicity of B10, a glycosylated derivative of betulinic acid. Fischer S, Ronellenfitsch MW, Thiepold AL, Harter PN, Reichert S, Kogel D, Paschke R, Mittelbronn M, Weller M, Steinbach JP, Fulda S, Bahr O. PLoS One. 2014 Apr 17;9(4):e94921. doi: 10.1371/journal.pone.0094921. eCollection 2014. PubMed |
| Capsaicin treatment attenuates cholangiocarcinoma carcinogenesis. Wutka A, Palagani V, Barat S, Chen X, El Khatib M, Gotze J, Belahmer H, Zender S, Bozko P, Malek NP, Plentz RR. PLoS One. 2014 Apr 18;9(4):e95605. doi: 10.1371/journal.pone.0095605. eCollection 2014. PubMed |
AP1S3 mutations are associated with pustular psoriasis and impaired Toll-like receptor 3 trafficking.
Setta-Kaffetzi N, Simpson MA, Navarini AA, Patel VM, Lu HC, Allen MH, Duckworth M, Bachelez H, Burden AD, Choon SE, Griffiths CE, Kirby B, Kolios A, Seyger MM, Prins C, Smahi A, Trembath RC, Fraternali F, Smith CH, Barker JN, Capon F.
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| Human papillomavirus 16 E6 contributes HIF-1alpha induced Warburg effect by attenuating the VHL-HIF-1alpha interaction. Guo Y, Meng X, Ma J, Zheng Y, Wang Q, Wang Y, Shang H. Int J Mol Sci. 2014 May 7;15(5):7974-86. doi: 10.3390/ijms15057974. PubMed |
| Cooperation of tyrosine kinase receptor TrkB and epidermal growth factor receptor signaling enhances migration and dispersal of lung tumor cells. Gotz R, Sendtner M. PLoS One. 2014 Jun 24;9(6):e100944. doi: 10.1371/journal.pone.0100944. eCollection 2014. PubMed |
Spatiotemporal control of fibroblast growth factor receptor signals by blue light.
Kim N, Kim JM, Lee M, Kim CY, Chang KY, Heo WD.
Chem Biol. 2014 Jul 17;21(7):903-12. doi: 10.1016/j.chembiol.2014.05.013. Epub 2014 Jun 26.
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| Dissecting engineered cell types and enhancing cell fate conversion via CellNet. Morris SA, Cahan P, Li H, Zhao AM, San Roman AK, Shivdasani RA, Collins JJ, Daley GQ. Cell. 2014 Aug 14;158(4):889-902. doi: 10.1016/j.cell.2014.07.021. PubMed |
| Complementation for an essential ancillary non-structural protein function across parvovirus genera. Mihaylov IS, Cotmore SF, Tattersall P. Virology. 2014 Nov;468-470:226-37. doi: 10.1016/j.virol.2014.07.043. Epub 2014 Sep 6. PubMed |
| Kruppel-like factor 6 interferes with cellular transformation induced by the H-ras oncogene. Trucco LD, Andreoli V, Nunez NG, Maccioni M, Bocco JL. FASEB J. 2014 Dec;28(12):5262-76. doi: 10.1096/fj.14-251884. Epub 2014 Sep 11. PubMed |
| PDGF-D expression is down-regulated by TGFbeta in fibroblasts. Charni Chaabane S, Coomans de Brachene A, Essaghir A, Velghe A, Lo Re S, Stockis J, Lucas S, Khachigian LM, Huaux F, Demoulin JB. PLoS One. 2014 Oct 3;9(10):e108656. doi: 10.1371/journal.pone.0108656. eCollection 2014. PubMed |
| The novel organic arsenical darinaparsin induces MAPK-mediated and SHP1-dependent cell death in T-cell lymphoma and Hodgkin lymphoma cells and human xenograft models. Ravi D, Bhalla S, Gartenhaus RB, Crombie J, Kandela I, Sharma J, Mazar A, Evens AM. Clin Cancer Res. 2014 Dec 1;20(23):6023-33. doi: 10.1158/1078-0432.CCR-14-1532. Epub 2014 Oct 14. PubMed |
| A platform for rapid prototyping of synthetic gene networks in mammalian cells. Duportet X, Wroblewska L, Guye P, Li Y, Eyquem J, Rieders J, Rimchala T, Batt G, Weiss R. Nucleic Acids Res. 2014 Dec 1;42(21):13440-51. doi: 10.1093/nar/gku1082. Epub 2014 Nov 5. PubMed |
| Generation and Neuronal Differentiation of Patient-Specific Induced Pluripotent Stem Cells Derived from Niemann-Pick Type C1 Fibroblasts. Trilck M, Hubner R, Frech MJ. Methods Mol Biol. 2014 Dec 18. PubMed |
| Targeting the effector domain of the myristoylated alanine rich C-kinase substrate enhances lung cancer radiation sensitivity. Rohrbach TD, Jarboe JS, Anderson JC, Trummell HQ, Hicks PH, Weaver AN, Yang ES, Oster RA, Deshane JS, Steele C, Siegal GP, Bonner JA, Willey CD. Int J Oncol. 2015 Mar;46(3):1079-88. doi: 10.3892/ijo.2014.2799. Epub 2014 Dec 17. PubMed |
| Progerin expression disrupts critical adult stem cell functions involved in tissue repair. Pacheco LM, Gomez LA, Dias J, Ziebarth NM, Howard GA, Schiller PC. Aging (Albany NY). 2014 Dec;6(12):1049-63. PubMed |
| ANKS6 is the critical activator of NEK8 kinase in embryonic situs determination and organ patterning. Czarnecki PG, Gabriel GC, Manning DK, Sergeev M, Lemke K, Klena NT, Liu X, Chen Y, Li Y, San Agustin JT, Garnaas MK, Francis RJ, Tobita K, Goessling W, Pazour GJ, Lo CW, Beier DR, Shah JV. Nat Commun. 2015 Jan 20;6:6023. doi: 10.1038/ncomms7023. PubMed |
| Alternative splicing regulates the expression of G9A and SUV39H2 methyltransferases, and dramatically changes SUV39H2 functions. Mauger O, Klinck R, Chabot B, Muchardt C, Allemand E, Batsche E. Nucleic Acids Res. 2015 Feb 18;43(3):1869-82. doi: 10.1093/nar/gkv013. Epub 2015 Jan 20. PubMed |
| DNA damage response factors from diverse pathways, including DNA crosslink repair, mediate alternative end joining. Howard SM, Yanez DA, Stark JM. PLoS Genet. 2015 Jan 28;11(1):e1004943. doi: 10.1371/journal.pgen.1004943. eCollection 2015 Jan. PubMed |
| F-actin bundles direct the initiation and orientation of lamellipodia through adhesion-based signaling. Johnson HE, King SJ, Asokan SB, Rotty JD, Bear JE, Haugh JM. J Cell Biol. 2015 Feb 16;208(4):443-55. doi: 10.1083/jcb.201406102. Epub 2015 Feb 9. PubMed |
| Innate immune response to Streptococcus pyogenes depends on the combined activation of TLR13 and TLR2. Fieber C, Janos M, Koestler T, Gratz N, Li XD, Castiglia V, Aberle M, Sauert M, Wegner M, Alexopoulou L, Kirschning CJ, Chen ZJ, von Haeseler A, Kovarik P. PLoS One. 2015 Mar 10;10(3):e0119727. doi: 10.1371/journal.pone.0119727. eCollection 2015. PubMed |
| RSPO2 Enhances Canonical Wnt Signaling to Confer Stemness-Associated Traits to Susceptible Pancreatic Cancer Cells. Ilmer M, Boiles AR, Regel I, Yokoi K, Michalski CW, Wistuba II, Rodriguez J, Alt E, Vykoukal J. Cancer Res. 2015 May 1;75(9):1883-96. doi: 10.1158/0008-5472.CAN-14-1327. Epub 2015 Mar 13. PubMed |
| A Proteomic Strategy Identifies Lysine Methylation of Splicing Factor snRNP70 by the SETMAR Enzyme. Carlson SM, Moore KE, Sankaran SM, Reynoird N, Elias JE, Gozani O. J Biol Chem. 2015 May 8;290(19):12040-7. doi: 10.1074/jbc.M115.641530. Epub 2015 Mar 20. PubMed |
| Loss of TGFbeta Receptor Type 2 Expression Impairs Estrogen Response and Confers Tamoxifen Resistance. Busch S, Sims AH, Stal O, Ferno M, Landberg G. Cancer Res. 2015 Apr 1;75(7):1457-69. doi: 10.1158/0008-5472.CAN-14-1583. PubMed |
| Proteasome inhibition enhances the killing effect of BikDD gene therapy. Sun Y, Ponz-Sarvise M, Chang SS, Chang WC, Chen CH, Hsu JL, Hung MC. Am J Transl Res. 2015 Feb 15;7(2):319-27. eCollection 2015. PubMed |
| Transglutaminase Is Required for Epidermal Squamous Cell Carcinoma Stem Cell Survival. Fisher ML, Keillor JW, Xu W, Eckert RL, Kerr C. Mol Cancer Res. 2015 Jul;13(7):1083-94. doi: 10.1158/1541-7786.MCR-14-0685-T. Epub 2015 May 1. PubMed |
| Type II transglutaminase stimulates epidermal cancer stem cell epithelial-mesenchymal transition. Fisher ML, Adhikary G, Xu W, Kerr C, Keillor JW, Eckert RL. Oncotarget. 2015 Aug 21;6(24):20525-39. PubMed |
| MALT1 is required for EGFR-induced NF-kappaB activation and contributes to EGFR-driven lung cancer progression. Pan D, Jiang C, Ma Z, Blonska M, You MJ, Lin X. Oncogene. 2015 May 18. doi: 10.1038/onc.2015.146. PubMed |
TRAFD1 (FLN29) Interacts with Plekhm1 and Regulates Osteoclast Acidification and Resorption.
Witwicka H, Jia H, Kutikov A, Reyes-Gutierrez P, Li X, Odgren PR.
PLoS One. 2015 May 19;10(5):e0127537. doi: 10.1371/journal.pone.0127537. eCollection 2015.
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| Cardiospecific CD36 suppression by lentivirus-mediated RNA interference prevents cardiac hypertrophy and systolic dysfunction in high-fat-diet induced obese mice. Zhang Y, Bao M, Dai M, Wang X, He W, Tan T, Lin D, Wang W, Wen Y, Zhang R. Cardiovasc Diabetol. 2015 Jun 3;14:69. doi: 10.1186/s12933-015-0234-z. PubMed |
| Tumors escape CD4+ T cell-mediated immunosurveillance by impairing the ability of infiltrating macrophages to indirectly present tumor antigens. Tveita AA, Schjesvold F, Haabeth OA, Fauskanger MH, Bogen B. Cancer Res. 2015 Jun 2. pii: canres.3640.2014. PubMed |
| CRISPR-Cas9-mediated gene knockout in primary human airway epithelial cells reveals a proinflammatory role for MUC18. Chu HW, Rios C, Huang C, Wesolowska-Andersen A, Burchard EG, O'Connor BP, Fingerlin TE, Nichols D, Reynolds SD, Seibold MA. Gene Ther. 2015 Jul 2. doi: 10.1038/gt.2015.53. PubMed |
| MYBL2 guides autophagy suppressor VDAC2 in the developing ovary to inhibit autophagy through a complex of VDAC2-BECN1-BCL2L1 in mammals. Yuan J, Zhang Y, Sheng Y, Fu X, Cheng H, Zhou R. Autophagy. 2015;11(7):1081-98. doi: 10.1080/15548627.2015.1040970. PubMed |
| More Tricks with Tetramers: A Practical Guide to Staining T cells with peptide-MHC Multimers. Dolton G, Tungatt K, Lloyd A, Bianchi V, Theaker SM, Trimby A, Holland CJ, Donia M, Godkin AJ, Cole DK, Straten PT, Peakman M, Svane IM, Sewell AK. Immunology. 2015 Jun 16. doi: 10.1111/imm.12499. PubMed |
| Dynamic Changes in Cytosolic ATP Levels in Cultured Glutamatergic Neurons During NMDA-Induced Synaptic Activity Supported by Glucose or Lactate. Lange SC, Winkler U, Andresen L, Byhro M, Waagepetersen HS, Hirrlinger J, Bak LK. Neurochem Res. 2015 Dec;40(12):2517-26. doi: 10.1007/s11064-015-1651-9. Epub 2015 Jul 17. PubMed |
| A Novel Role of E-Cadherin-Based Adherens Junctions in Neoplastic Cell Dissemination. Rubtsova SN, Zhitnyak IY, Gloushankova NA. PLoS One. 2015 Jul 24;10(7):e0133578. doi: 10.1371/journal.pone.0133578. eCollection 2015. PubMed |
| Heat shock factor 1 induces cancer stem cell phenotype in breast cancer cell lines. Wang B, Lee CW, Witt A, Thakkar A, Ince TA. Breast Cancer Res Treat. 2015 Aug;153(1):57-66. doi: 10.1007/s10549-015-3521-1. Epub 2015 Jul 30. PubMed |
Mammalian synthetic circuits with RNA binding proteins for RNA-only delivery.
Wroblewska L, Kitada T, Endo K, Siciliano V, Stillo B, Saito H, Weiss R.
Nat Biotechnol. 2015 Aug 3. doi: 10.1038/nbt.3301.
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Associated Plasmids |
Improvement of HIV-1 and Human T Cell Lymphotropic Virus Type 1 Replication-Dependent Vectors via Optimization of Reporter Gene Reconstitution and Modification with Intronic Short Hairpin RNA.
Shunaeva A, Potashnikova D, Pichugin A, Mishina A, Filatov A, Nikolaitchik O, Hu WS, Mazurov D.
J Virol. 2015 Oct 15;89(20):10591-601. doi: 10.1128/JVI.01940-15. Epub 2015 Aug 12.
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| hVGAT-mCherry: A novel molecular tool for analysis of GABAergic neurons derived from human pluripotent stem cells. DeRosa BA, Belle KC, Thomas BJ, Cukier HN, Pericak-Vance MA, Vance JM, Dykxhoorn DM. Mol Cell Neurosci. 2015 Sep;68:244-57. doi: 10.1016/j.mcn.2015.08.007. Epub 2015 Aug 16. PubMed |
| Retroviral Transduction of T Cells and T Cell Precursors. Simmons A, Alberola-Ila J. Methods Mol Biol. 2016;1323:99-108. doi: 10.1007/978-1-4939-2809-5_8. PubMed |
| Inhibition of adipose triglyceride lipase (ATGL) by the putative tumor suppressor G0S2 or a small molecule inhibitor attenuates the growth of cancer cells. Zagani R, El-Assaad W, Gamache I, Teodoro JG. Oncotarget. 2015 Sep 29;6(29):28282-95. doi: 10.18632/oncotarget.5061. PubMed |
| Derivation of LIF-independent mouse iPS cells with modified Oct4. Hirai H, Firpo M, Kikyo N. Stem Cell Res. 2015 Sep;15(2):384-6. doi: 10.1016/j.scr.2015.08.005. Epub 2015 Aug 17. PubMed |
Identification of an oncogenic RAB protein.
Wheeler DB, Zoncu R, Root DE, Sabatini DM, Sawyers CL.
Science. 2015 Oct 9;350(6257):211-7. doi: 10.1126/science.aaa4903. Epub 2015 Sep 3.
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| Use of genetically-encoded calcium indicators for live cell calcium imaging and localization in virus-infected cells. Perry JL, Ramachandran NK, Utama B, Hyser JM. Methods. 2015 Nov 15;90:28-38. doi: 10.1016/j.ymeth.2015.09.004. Epub 2015 Sep 3. PubMed |
| The Deleted in Liver Cancer 1 (Dlc1) tumor suppressor is haploinsufficient for mammary gland development and epithelial cell polarity. Basak P, Dillon R, Leslie H, Raouf A, Mowat MR. BMC Cancer. 2015 Sep 9;15:630. doi: 10.1186/s12885-015-1642-x. PubMed |
| CRISPR/Cas9 System as an Agent for Eliminating Polyomavirus JC Infection. Wollebo HS, Bellizzi A, Kaminski R, Hu W, White MK, Khalili K. PLoS One. 2015 Sep 11;10(9):e0136046. doi: 10.1371/journal.pone.0136046. eCollection 2015. PubMed |
| Expression profiling of in vivo ductal carcinoma in situ progression models identified B cell lymphoma-9 as a molecular driver of breast cancer invasion. Elsarraj HS, Hong Y, Valdez KE, Michaels W, Hook M, Smith WP, Chien J, Herschkowitz JI, Troester MA, Beck M, Inciardi M, Gatewood J, May L, Cusick T, McGinness M, Ricci L, Fan F, Tawfik O, Marks JR, Knapp JR, Yeh HW, Thomas P, Carrasco DR, Fields TA, Godwin AK, Behbod F. Breast Cancer Res. 2015 Sep 17;17:128. doi: 10.1186/s13058-015-0630-z. PubMed |
| SLUG is required for SOX9 stabilization and functions to promote cancer stem cells and metastasis in human lung carcinoma. Luanpitpong S, Li J, Manke A, Brundage K, Ellis E, McLaughlin SL, Angsutararux P, Chanthra N, Voronkova M, Chen YC, Wang L, Chanvorachote P, Pei M, Issaragrisil S, Rojanasakul Y. Oncogene. 2015 Sep 21. doi: 10.1038/onc.2015.351. PubMed |
| Histone Deacetylase 3 Coordinates Deacetylase-independent Epigenetic Silencing of Transforming Growth Factor-beta1 (TGF-beta1) to Orchestrate Second Heart Field Development. Lewandowski SL, Janardhan HP, Trivedi CM. J Biol Chem. 2015 Nov 6;290(45):27067-89. doi: 10.1074/jbc.M115.684753. Epub 2015 Sep 29. PubMed |
| ZIC2-dependent OCT4 activation drives self-renewal of human liver cancer stem cells. Zhu P, Wang Y, He L, Huang G, Du Y, Zhang G, Yan X, Xia P, Ye B, Wang S, Hao L, Wu J, Fan Z. J Clin Invest. 2015 Oct 1;125(10):3795-808. doi: 10.1172/JCI81979. Epub 2015 Aug 31. PubMed |
| MCL-1-independent mechanisms of synergy between dual PI3K/mTOR and BCL-2 inhibition in diffuse large B cell lymphoma. Lee JS, Tang SS, Ortiz V, Vo TT, Fruman DA. Oncotarget. 2015 Nov 3;6(34):35202-17. doi: 10.18632/oncotarget.6051. PubMed |
| The Effector Domain of MARCKS Is a Nuclear Localization Signal that Regulates Cellular PIP2 Levels and Nuclear PIP2 Localization. Rohrbach TD, Shah N, Jackson WP, Feeney EV, Scanlon S, Gish R, Khodadadi R, Hyde SO, Hicks PH, Anderson JC, Jarboe JS, Willey CD. PLoS One. 2015 Oct 15;10(10):e0140870. doi: 10.1371/journal.pone.0140870. eCollection 2015. PubMed |
| NRF2 regulates serine biosynthesis in non-small cell lung cancer. DeNicola GM, Chen PH, Mullarky E, Sudderth JA, Hu Z, Wu D, Tang H, Xie Y, Asara JM, Huffman KE, Wistuba II, Minna JD, DeBerardinis RJ, Cantley LC. Nat Genet. 2015 Dec;47(12):1475-81. doi: 10.1038/ng.3421. Epub 2015 Oct 19. PubMed |
| Inducing Pluripotency in Cattle. Malaver-Ortega LF, Taheri-Ghahfarokhi A, Sumer H. Methods Mol Biol. 2015;1330:57-68. doi: 10.1007/978-1-4939-2848-4_6. PubMed |
| A PCR-Based Method to Construct Lentiviral Vector Expressing Double Tough Decoy for miRNA Inhibition. Qiu H, Zhong J, Luo L, Liu N, Kang K, Qu J, Peng W, Gou D. PLoS One. 2015 Dec 1;10(12):e0143864. doi: 10.1371/journal.pone.0143864. eCollection 2015. PubMed |
| A new design of a lentiviral shRNA vector with inducible co-expression of ARGONAUTE 2 for enhancing gene silencing efficiency. He J, Huang L, Qiu H, Li J, Luo L, Li Y, Tian S, Kang K, Luo J, Liu L, Gou D. Cell Biosci. 2015 Dec 8;5:67. doi: 10.1186/s13578-015-0058-2. eCollection 2015. PubMed |
| Long-acting cocaine hydrolase for addiction therapy. Chen X, Xue L, Hou S, Jin Z, Zhang T, Zheng F, Zhan CG. Proc Natl Acad Sci U S A. 2016 Jan 12;113(2):422-7. doi: 10.1073/pnas.1517713113. Epub 2015 Dec 28. PubMed |
| Sphingosine kinase 1 is required for TGF-beta mediated fibroblastto- myofibroblast differentiation in ovarian cancer. Beach JA, Aspuria PJ, Cheon DJ, Lawrenson K, Agadjanian H, Walsh CS, Karlan BY, Orsulic S. Oncotarget. 2016 Jan 26;7(4):4167-82. doi: 10.18632/oncotarget.6703. PubMed |
| Genetically engineering self-organization of human pluripotent stem cells into a liver bud-like tissue using Gata6. Guye P, Ebrahimkhani MR, Kipniss N, Velazquez JJ, Schoenfeld E, Kiani S, Griffith LG, Weiss R. Nat Commun. 2016 Jan 6;7:10243. doi: 10.1038/ncomms10243. PubMed |
| Human iPS cell model of type 3 long QT syndrome recapitulates drug-based phenotype correction. Malan D, Zhang M, Stallmeyer B, Muller J, Fleischmann BK, Schulze-Bahr E, Sasse P, Greber B. Basic Res Cardiol. 2016 Mar;111(2):14. doi: 10.1007/s00395-016-0530-0. Epub 2016 Jan 23. PubMed |
| Opposing Roles of JNK and p38 in Lymphangiogenesis in Melanoma. Puujalka E, Heinz M, Hoesel B, Friedl P, Schweighofer B, Wenzina J, Pirker C, Schmid JA, Loewe R, Wagner EF, Berger W, Petzelbauer P. J Invest Dermatol. 2016 May;136(5):967-77. doi: 10.1016/j.jid.2016.01.020. Epub 2016 Jan 30. PubMed |
| Characterization of Two-Pore Channel 2 by Nuclear Membrane Electrophysiology. Lee CS, Tong BC, Cheng CW, Hung HC, Cheung KH. Sci Rep. 2016 Feb 3;6:20282. doi: 10.1038/srep20282. PubMed |
| Inhibition of JAK-STAT ERK/MAPK and Glycogen Synthase Kinase-3 Induces a Change in Gene Expression Profile of Bovine Induced Pluripotent Stem Cells. Malaver-Ortega LF, Sumer H, Liu J, Verma PJ. Stem Cells Int. 2016;2016:5127984. doi: 10.1155/2016/5127984. Epub 2016 Jan 6. PubMed |
| Iron induces cancer stem cells and aggressive phenotypes in human lung cancer cells. Chanvorachote P, Luanpitpong S. Am J Physiol Cell Physiol. 2016 May 1;310(9):C728-39. doi: 10.1152/ajpcell.00322.2015. Epub 2016 Feb 24. PubMed |
| Phosphorylation-Dependent Regulation of the DNA Damage Response of Adaptor Protein KIBRA in Cancer Cells. Mavuluri J, Beesetti S, Surabhi R, Kremerskothen J, Venkatraman G, Rayala SK. Mol Cell Biol. 2016 Apr 15;36(9):1354-65. doi: 10.1128/MCB.01004-15. Print 2016 May 1. PubMed |
| The retrovirus HTLV-1 inserts an ectopic CTCF-binding site into the human genome. Satou Y, Miyazato P, Ishihara K, Yaguchi H, Melamed A, Miura M, Fukuda A, Nosaka K, Watanabe T, Rowan AG, Nakao M, Bangham CR. Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):3054-9. doi: 10.1073/pnas.1423199113. Epub 2016 Feb 29. PubMed |
| Inhibition of Focal Adhesion Kinase Signaling by Integrin alpha6beta1 Supports Human Pluripotent Stem Cell Self-Renewal. Villa-Diaz LG, Kim JK, Laperle A, Palecek SP, Krebsbach PH. Stem Cells. 2016 Jul;34(7):1753-64. doi: 10.1002/stem.2349. Epub 2016 Mar 27. PubMed |
| Viral Packaging and Cell Culture for CRISPR-Based Screens. Wang T, Lander ES, Sabatini DM. Cold Spring Harb Protoc. 2016 Mar 1;2016(3):pdb.prot090811. doi: 10.1101/pdb.prot090811. PubMed |
| Editing of mouse and human immunoglobulin genes by CRISPR-Cas9 system. Cheong TC, Compagno M, Chiarle R. Nat Commun. 2016 Mar 9;7:10934. doi: 10.1038/ncomms10934. PubMed |
| Deacetylation Assays to Unravel the Interplay between Sirtuins (SIRT2) and Specific Protein-substrates. Song HY, Park SH, Kang HJ, Vassilopoulos A. J Vis Exp. 2016 Feb 27;(108). doi: 10.3791/53563. PubMed |
| Activation of individual L1 retrotransposon instances is restricted to cell-type dependent permissive loci. Philippe C, Vargas-Landin DB, Doucet AJ, van Essen D, Vera-Otarola J, Kuciak M, Corbin A, Nigumann P, Cristofari G. Elife. 2016 Mar 26;5. pii: e13926. doi: 10.7554/eLife.13926. PubMed |
| Control of glioblastoma tumorigenesis by feed-forward cytokine signaling. Jahani-Asl A, Yin H, Soleimani VD, Haque T, Luchman HA, Chang NC, Sincennes MC, Puram SV, Scott AM, Lorimer IA, Perkins TJ, Ligon KL, Weiss S, Rudnicki MA, Bonni A. Nat Neurosci. 2016 Jun;19(6):798-806. doi: 10.1038/nn.4295. Epub 2016 Apr 25. PubMed |
| An essential role for Grk2 in Hedgehog signalling downstream of Smoothened. Zhao Z, Lee RT, Pusapati GV, Iyu A, Rohatgi R, Ingham PW. EMBO Rep. 2016 May;17(5):739-52. doi: 10.15252/embr.201541532. Epub 2016 Apr 4. PubMed |
| The mitochondrial calcium uniporter regulates breast cancer progression via HIF-1alpha. Tosatto A, Sommaggio R, Kummerow C, Bentham RB, Blacker TS, Berecz T, Duchen MR, Rosato A, Bogeski I, Szabadkai G, Rizzuto R, Mammucari C. EMBO Mol Med. 2016 May 2;8(5):569-85. doi: 10.15252/emmm.201606255. PubMed |
| Analysis of Nuclear Lamina Proteins in Myoblast Differentiation by Functional Complementation. Tapia O, Gerace L. Methods Mol Biol. 2016;1411:177-94. doi: 10.1007/978-1-4939-3530-7_11. PubMed |
| Engineering and Functional Analysis of Mitotic Kinases Through Chemical Genetics. Jones MJ, Jallepalli PV. Methods Mol Biol. 2016;1413:349-63. doi: 10.1007/978-1-4939-3542-0_22. PubMed |
| Interferon-induced sterile alpha motif and histidine/aspartic acid domain-containing protein 1 expression in astrocytes and microglia is mediated by microRNA-181a. Jin C, Peng X, Liu F, Cheng L, Xie T, Lu X, Wu H, Wu N. AIDS. 2016 Aug 24;30(13):2053-64. doi: 10.1097/QAD.0000000000001166. PubMed |
| Measuring IL-1beta Processing by Bioluminescence Sensors II: The iGLuc System. Bartok E, Kampes M, Hornung V. Methods Mol Biol. 2016;1417:97-113. doi: 10.1007/978-1-4939-3566-6_6. PubMed |
| Integrin alphavbeta3 enhances beta-catenin signaling in acute myeloid leukemia harboring Fms-like tyrosine kinase-3 internal tandem duplication mutations: implications for microenvironment influence on sorafenib sensitivity. Yi H, Zeng D, Shen Z, Liao J, Wang X, Liu Y, Zhang X, Kong P. Oncotarget. 2016 Jun 28;7(26):40387-40397. doi: 10.18632/oncotarget.9617. PubMed |
| Autocrine Complement Inhibits IL10-Dependent T-Cell Mediated Antitumor Immunity to Promote Tumor Progression. Wang Y, Sun SN, Liu Q, Yu YY, Guo J, Wang K, Xing BC, Zheng QF, Campa MJ, Patz EF, Li SY, He YW. Cancer Discov. 2016 Jun 13. pii: CD-15-1412. PubMed |
| MicroRNA-17-92 regulates myoblast proliferation and differentiation by targeting the ENH1/Id1 signaling axis. Qiu H, Liu N, Luo L, Zhong J, Tang Z, Kang K, Qu J, Peng W, Liu L, Li L, Gou D. Cell Death Differ. 2016 Jun 17. doi: 10.1038/cdd.2016.56. PubMed |
| YPEL4 modulates HAC15 adrenal cell proliferation and is associated with tumor diameter. Oki K, Plonczynski MW, Gomez-Sanchez EP, Gomez-Sanchez CE. Mol Cell Endocrinol. 2016 Oct 15;434:93-8. doi: 10.1016/j.mce.2016.06.022. Epub 2016 Jun 19. PubMed |
| RNAi-mediated silencing of HLA A2 suppressed acute rejection against human fibroblast xenografts in the striatum of 6-OHDA lesioned rats. Liang C, Xu Y, Zheng D, Sun X, Xu Q, Duan D. J Neuroimmunol. 2016 Aug 15;297:28-37. doi: 10.1016/j.jneuroim.2016.05.002. Epub 2016 May 3. PubMed |
| Role of SUMO activating enzyme in cancer stem cell maintenance and self-renewal. Du L, Li YJ, Fakih M, Wiatrek RL, Duldulao M, Chen Z, Chu P, Garcia-Aguilar J, Chen Y. Nat Commun. 2016 Jul 28;7:12326. doi: 10.1038/ncomms12326. PubMed |
| Prevention of Proliferative Vitreoretinopathy by Suppression of Phosphatidylinositol 5-Phosphate 4-Kinases. Ma G, Duan Y, Huang X, Qian CX, Chee Y, Mukai S, Cui J, Samad A, Matsubara JA, Kazlauskas A, D'Amore PA, Gu S, Lei H. Invest Ophthalmol Vis Sci. 2016 Jul 1;57(8):3935-43. doi: 10.1167/iovs.16-19405. PubMed |
| Negative Feedback Regulation of HIV-1 by Gene Editing Strategy. Kaminski R, Chen Y, Salkind J, Bella R, Young WB, Ferrante P, Karn J, Malcolm T, Hu W, Khalili K. Sci Rep. 2016 Aug 16;6:31527. doi: 10.1038/srep31527. PubMed |
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| Generation of Luciferase-expressing Tumor Cell Lines. Brennan TV, Lin L, Huang X, Yang Y. Bio Protoc. 2018 Apr 20;8(8). doi: 10.21769/BioProtoc.2817. PubMed |
| A versatile lentiviral delivery toolkit for proximity-dependent biotinylation in diverse cell types. Samavarchi-Tehrani P, Abdouni H, Samson R, Gingras AC. Mol Cell Proteomics. 2018 Jul 10. pii: TIR118.000902. doi: 10.1074/mcp.TIR118.000902. PubMed |
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| Translational Control through Differential Ribosome Pausing during Amino Acid Limitation in Mammalian Cells. Darnell AM, Subramaniam AR, O'Shea EK. Mol Cell. 2018 Jul 19;71(2):229-243.e11. doi: 10.1016/j.molcel.2018.06.041. PubMed |
Mitochondrial inner membrane permeabilisation enables mtDNA release during apoptosis.
Riley JS, Quarato G, Cloix C, Lopez J, O'Prey J, Pearson M, Chapman J, Sesaki H, Carlin LM, Passos JF, Wheeler AP, Oberst A, Ryan KM, Tait SW.
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| Regulation of the adaptation to ER stress by KLF4 facilitates melanoma cell metastasis via upregulating NUCB2 expression. Zhang D, Lin J, Chao Y, Zhang L, Jin L, Li N, He R, Ma B, Zhao W, Han C. J Exp Clin Cancer Res. 2018 Jul 28;37(1):176. doi: 10.1186/s13046-018-0842-z. PubMed |
| Entry Inhibition and Modulation of Pro-Inflammatory Immune Response Against Influenza A Virus by a Recombinant Truncated Surfactant Protein D. Al-Ahdal MN, Murugaiah V, Varghese PM, Abozaid SM, Saba I, Al-Qahtani AA, Pathan AA, Kouser L, Nal B, Kishore U. Front Immunol. 2018 Jul 30;9:1586. doi: 10.3389/fimmu.2018.01586. eCollection 2018. PubMed |
| Signatures of T cell dysfunction and exclusion predict cancer immunotherapy response. Jiang P, Gu S, Pan D, Fu J, Sahu A, Hu X, Li Z, Traugh N, Bu X, Li B, Liu J, Freeman GJ, Brown MA, Wucherpfennig KW, Liu XS. Nat Med. 2018 Oct;24(10):1550-1558. doi: 10.1038/s41591-018-0136-1. Epub 2018 Aug 20. PubMed |
| SHLD2/FAM35A co-operates with REV7 to coordinate DNA double-strand break repair pathway choice. Findlay S, Heath J, Luo VM, Malina A, Morin T, Coulombe Y, Djerir B, Li Z, Samiei A, Simo-Cheyou E, Karam M, Bagci H, Rahat D, Grapton D, Lavoie EG, Dove C, Khaled H, Kuasne H, Mann KK, Klein KO, Greenwood CM, Tabach Y, Park M, Cote JF, Masson JY, Marechal A, Orthwein A. EMBO J. 2018 Sep 14;37(18). pii: embj.2018100158. doi: 10.15252/embj.2018100158. Epub 2018 Aug 28. PubMed |
| Tbx1 represses Mef2c gene expression and is correlated with histone 3 deacetylation of the anterior heart field enhancer. Pane LS, Fulcoli FG, Cirino A, Altomonte A, Ferrentino R, Bilio M, Baldini A. Dis Model Mech. 2018 Aug 30;11(9). pii: 11/9/dmm029967. doi: 10.1242/dmm.029967. PubMed |
| KLF4, a miR-32-5p targeted gene, promotes cisplatin-induced apoptosis by upregulating BIK expression in prostate cancer. Zhang L, Li X, Chao Y, He R, Liu J, Yuan Y, Zhao W, Han C, Song X. Cell Commun Signal. 2018 Sep 3;16(1):53. doi: 10.1186/s12964-018-0270-x. PubMed |
| The cargo receptor SURF4 promotes the efficient cellular secretion of PCSK9. Emmer BT, Hesketh GG, Kotnik E, Tang VT, Lascuna PJ, Xiang J, Gingras AC, Chen XW, Ginsburg D. Elife. 2018 Sep 25;7. pii: 38839. doi: 10.7554/eLife.38839. PubMed |
| Reactive oxygen species mediate cancer stem-like cells and determine bortezomib sensitivity via Mcl-1 and Zeb-1 in mantle cell lymphoma. Luanpitpong S, Poohadsuan J, Samart P, Kiratipaiboon C, Rojanasakul Y, Issaragrisil S. Biochim Biophys Acta Mol Basis Dis. 2018 Nov;1864(11):3739-3753. doi: 10.1016/j.bbadis.2018.09.010. Epub 2018 Sep 11. PubMed |
| Breast cancer survival predicted by TP53 mutation status differs markedly depending on treatment. Ungerleider NA, Rao SG, Shahbandi A, Yee D, Niu T, Frey WD, Jackson JG. Breast Cancer Res. 2018 Oct 1;20(1):115. doi: 10.1186/s13058-018-1044-5. PubMed |
Treatment of a metabolic liver disease by in vivo genome base editing in adult mice.
Villiger L, Grisch-Chan HM, Lindsay H, Ringnalda F, Pogliano CB, Allegri G, Fingerhut R, Haberle J, Matos J, Robinson MD, Thony B, Schwank G.
Nat Med. 2018 Oct;24(10):1519-1525. doi: 10.1038/s41591-018-0209-1. Epub 2018 Oct 8.
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| Genome-wide CRISPR-Cas9 viability screen reveals genes involved in TNF-alpha-induced apoptosis of human umbilical vein endothelial cells. Cai M, Li S, Shuai Y, Li J, Tan J, Zeng Q. J Cell Physiol. 2019 Jun;234(6):9184-9193. doi: 10.1002/jcp.27595. Epub 2018 Oct 14. PubMed |
| FRA1 mediates the activation of keratinocytes: Implications for the development of psoriatic plaques. Zolotarenko A, Chekalin E, Piruzian E, Bruskin S. Biochim Biophys Acta Mol Basis Dis. 2018 Dec;1864(12):3726-3734. doi: 10.1016/j.bbadis.2018.09.016. Epub 2018 Sep 14. PubMed |
| Ubiquitin-specific peptidase 2a (USP2a) deubiquitinates and stabilizes beta-catenin. Kim J, Alavi Naini F, Sun Y, Ma L. Am J Cancer Res. 2018 Sep 1;8(9):1823-1836. eCollection 2018. PubMed |
| Tracing the transitions from pluripotency to germ cell fate with CRISPR screening. Hackett JA, Huang Y, Gunesdogan U, Gretarsson KA, Kobayashi T, Surani MA. Nat Commun. 2018 Oct 16;9(1):4292. doi: 10.1038/s41467-018-06230-0. PubMed |
| Plexin C1 Marks Liver Cancer Cells with Epithelial Phenotype and Is Overexpressed in Hepatocellular Carcinoma. Odabas G, Cetin M, Turhal S, Baloglu H, Sayan AE, Yagci T. Can J Gastroenterol Hepatol. 2018 Sep 19;2018:4040787. doi: 10.1155/2018/4040787. eCollection 2018. PubMed |
The Lineage-Defining Transcription Factors SOX2 and NKX2-1 Determine Lung Cancer Cell Fate and Shape the Tumor Immune Microenvironment.
Mollaoglu G, Jones A, Wait SJ, Mukhopadhyay A, Jeong S, Arya R, Camolotto SA, Mosbruger TL, Stubben CJ, Conley CJ, Bhutkar A, Vahrenkamp JM, Berrett KC, Cessna MH, Lane TE, Witt BL, Salama ME, Gertz J, Jones KB, Snyder EL, Oliver TG.
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Associated Plasmids |
| INAVA-ARNO complexes bridge mucosal barrier function with inflammatory signaling. Luong P, Hedl M, Yan J, Zuo T, Fu TM, Jiang X, Thiagarajah JR, Hansen SH, Lesser CF, Wu H, Abraham C, Lencer WI. Elife. 2018 Oct 25;7. pii: 38539. doi: 10.7554/eLife.38539. PubMed |
| RbAp48 Protein Is a Critical Component of GPR158/OCN Signaling and Ameliorates Age-Related Memory Loss. Kosmidis S, Polyzos A, Harvey L, Youssef M, Denny CA, Dranovsky A, Kandel ER. Cell Rep. 2018 Oct 23;25(4):959-973.e6. doi: 10.1016/j.celrep.2018.09.077. PubMed |
| Discovery of Natural Compounds Promoting Cardiomyocyte Differentiation. Lee JA, An J, Kang TM, De D, Kim KK. Stem Cells Dev. 2019 Jan 1;28(1):13-27. doi: 10.1089/scd.2018.0153. Epub 2018 Dec 4. PubMed |
| Lentivirus-Mediated RNAi in Skeletal Myogenesis. Kim D, Reyes-Ordonez A, Chen J. Methods Mol Biol. 2019;1889:95-110. doi: 10.1007/978-1-4939-8897-6_7. PubMed |
| Genomic sequencing and editing revealed the GRM8 signaling pathway as potential therapeutic targets of squamous cell lung cancer. Zhang P, Kang B, Xie G, Li S, Gu Y, Shen Y, Zhao X, Ma Y, Li F, Si J, Wang J, Chen J, Yang H, Xu X, Yang Y. Cancer Lett. 2019 Feb 1;442:53-67. doi: 10.1016/j.canlet.2018.10.035. Epub 2018 Oct 27. PubMed |
| MiRNA-27a sensitizes breast cancer cells to treatment with Selective Estrogen Receptor Modulators. Ljepoja B, Garcia-Roman J, Sommer AK, Wagner E, Roidl A. Breast. 2019 Feb;43:31-38. doi: 10.1016/j.breast.2018.10.007. Epub 2018 Oct 18. PubMed |
| Podoplanin expression is a prognostic biomarker but may be dispensable for the malignancy of glioblastoma. Eisemann T, Costa B, Harter PN, Wick W, Mittelbronn M, Angel P, Peterziel H. Neuro Oncol. 2018 Nov 10. pii: 5168873. doi: 10.1093/neuonc/noy184. PubMed |
| Fibroblast Growth Factor 2 lethally sensitizes cancer cells to stress-targeted therapeutic inhibitors. Dias MH, Fonseca CS, Zeidler JD, Albuquerque LL, da Silva MS, Cararo-Lopes E, Reis MS, Noel V, Dos Santos EO, Prior IA, Armelin HA. Mol Oncol. 2019 Feb;13(2):290-306. doi: 10.1002/1878-0261.12402. Epub 2018 Dec 3. PubMed |
| PPPDE1 promotes hepatocellular carcinoma development by negatively regulate p53 and apoptosis. Xie X, Wang X, Liao W, Fei R, Wu N, Cong X, Chen Q, Wei L, Wang Y, Chen H. Apoptosis. 2019 Feb;24(1-2):135-144. doi: 10.1007/s10495-018-1491-6. PubMed |
| MiR-708-5p is inversely associated with EWS/FLI1 Ewing sarcoma but does not represent a prognostic predictor. Roberto GM, Vieira GM, Delsin LEA, Silva MO, Hakime RG, Engel EE, Scrideli CA, Tone LG, Brassesco MS. Cancer Genet. 2019 Jan;230:21-27. doi: 10.1016/j.cancergen.2018.11.003. Epub 2018 Nov 13. PubMed |
| RORalpha controls inflammatory state of human macrophages. Nejati Moharrami N, Bjorkoy Tande E, Ryan L, Espevik T, Boyartchuk V. PLoS One. 2018 Nov 28;13(11):e0207374. doi: 10.1371/journal.pone.0207374. eCollection 2018. PubMed |
| Interplay between transcription regulators RUNX1 and FUBP1 activates an enhancer of the oncogene c-KIT and amplifies cell proliferation. Debaize L, Jakobczyk H, Avner S, Gaudichon J, Rio AG, Serandour AA, Dorsheimer L, Chalmel F, Carroll JS, Zornig M, Rieger MA, Delalande O, Salbert G, Galibert MD, Gandemer V, Troadec MB. Nucleic Acids Res. 2018 Nov 30;46(21):11214-11228. doi: 10.1093/nar/gky756. PubMed |
| Generation of Stable Expression Mammalian Cell Lines Using Lentivirus. Tandon N, Thakkar KN, LaGory EL, Liu Y, Giaccia AJ. Bio Protoc. 2018 Nov 5;8(21). doi: 10.21769/BioProtoc.3073. PubMed |
| Inhibition of Membrane-Bound BAFF by the Anti-BAFF Antibody Belimumab. Kowalczyk-Quintas C, Chevalley D, Willen L, Jandus C, Vigolo M, Schneider P. Front Immunol. 2018 Nov 20;9:2698. doi: 10.3389/fimmu.2018.02698. eCollection 2018. PubMed |
| ATP13A2 facilitates HDAC6 recruitment to lysosome to promote autophagosome-lysosome fusion. Wang R, Tan J, Chen T, Han H, Tian R, Tan Y, Wu Y, Cui J, Chen F, Li J, Lv L, Guan X, Shang S, Lu J, Zhang Z. J Cell Biol. 2019 Jan 7;218(1):267-284. doi: 10.1083/jcb.201804165. Epub 2018 Dec 11. PubMed |
| Intersectin-1 interacts with the golgin GCC88 to couple the actin network and Golgi architecture. Makhoul C, Gosavi P, Duffield R, Delbridge B, Williamson NA, Gleeson PA. Mol Biol Cell. 2019 Feb 1;30(3):370-386. doi: 10.1091/mbc.E18-05-0313. Epub 2018 Dec 12. PubMed |
| Genome-Wide CRISPR/Cas9 Screening for Identification of Cancer Genes in Cell Lines. Adelmann CH, Wang T, Sabatini DM, Lander ES. Methods Mol Biol. 2019;1907:125-136. doi: 10.1007/978-1-4939-8967-6_10. PubMed |
| Disruption of protein neddylation with MLN4924 attenuates paclitaxel-induced apoptosis and microtubule polymerization in ovarian cancer cells. Hong X, Li S, Li W, Xie M, Wei Z, Guo H, Wei W, Zhang S. Biochem Biophys Res Commun. 2019 Jan 15;508(3):986-990. doi: 10.1016/j.bbrc.2018.12.048. Epub 2018 Dec 11. PubMed |
| Regulation of mitochondrial iron homeostasis by sideroflexin 2. Mon EE, Wei FY, Ahmad RNR, Yamamoto T, Moroishi T, Tomizawa K. J Physiol Sci. 2019 Mar;69(2):359-373. doi: 10.1007/s12576-018-0652-2. Epub 2018 Dec 20. PubMed |
Optimized libraries for CRISPR-Cas9 genetic screens with multiple modalities.
Sanson KR, Hanna RE, Hegde M, Donovan KF, Strand C, Sullender ME, Vaimberg EW, Goodale A, Root DE, Piccioni F, Doench JG.
Nat Commun. 2018 Dec 21;9(1):5416. doi: 10.1038/s41467-018-07901-8.
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| Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis. Tiemann K, Garri C, Lee SB, Malihi PD, Park M, Alvarez RM, Yap LP, Mallick P, Katz JE, Gross ME, Kani K. Oncogene. 2019 Apr;38(16):3003-3018. doi: 10.1038/s41388-018-0638-9. Epub 2018 Dec 21. PubMed |
| Allosteric Inhibition of Ubiquitin-like Modifications by a Class of Inhibitor of SUMO-Activating Enzyme. Li YJ, Du L, Wang J, Vega R, Lee TD, Miao Y, Aldana-Masangkay G, Samuels ER, Li B, Ouyang SX, Colayco SA, Bobkova EV, Divlianska DB, Sergienko E, Chung TDY, Fakih M, Chen Y. Cell Chem Biol. 2019 Feb 21;26(2):278-288.e6. doi: 10.1016/j.chembiol.2018.10.026. Epub 2018 Dec 20. PubMed |
| Sensitive ADAR editing reporter in cancer cells enables high-throughput screening of small molecule libraries. Fritzell K, Xu LD, Otrocka M, Andreasson C, Ohman M. Nucleic Acids Res. 2019 Feb 28;47(4):e22. doi: 10.1093/nar/gky1228. PubMed |
| IL-8 Secreted from M2 Macrophages Promoted Prostate Tumorigenesis via STAT3/MALAT1 Pathway. Zheng T, Ma G, Tang M, Li Z, Xu R. Int J Mol Sci. 2018 Dec 27;20(1). pii: ijms20010098. doi: 10.3390/ijms20010098. PubMed |
| Novel mutations in mevalonate kinase cause disseminated superficial actinic porokeratosis. Zhu T, Tian D, Zhang L, Xu X, Xia K, Hu Z, Xiong Z, Tan J. Br J Dermatol. 2018 Dec 30. doi: 10.1111/bjd.17596. PubMed |
| Structural insights into trans-histone regulation of H3K4 methylation by unique histone H4 binding of MLL3/4. Liu Y, Qin S, Chen TY, Lei M, Dhar SS, Ho JC, Dong A, Loppnau P, Li Y, Lee MG, Min J. Nat Commun. 2019 Jan 3;10(1):36. doi: 10.1038/s41467-018-07906-3. PubMed |
| Growth Factor-Independent 1 Is a Tumor Suppressor Gene in Colorectal Cancer. Chen MS, Lo YH, Chen X, Williams CS, Donnelly JM, Criss ZK 2nd, Patel S, Butkus JM, Dubrulle J, Finegold MJ, Shroyer NF. Mol Cancer Res. 2019 Mar;17(3):697-708. doi: 10.1158/1541-7786.MCR-18-0666. Epub 2019 Jan 3. PubMed |
| UBQLN4 Represses Homologous Recombination and Is Overexpressed in Aggressive Tumors. Jachimowicz RD, Beleggia F, Isensee J, Velpula BB, Goergens J, Bustos MA, Doll MA, Shenoy A, Checa-Rodriguez C, Wiederstein JL, Baranes-Bachar K, Bartenhagen C, Hertwig F, Teper N, Nishi T, Schmitt A, Distelmaier F, Ludecke HJ, Albrecht B, Kruger M, Schumacher B, Geiger T, Hoon DSB, Huertas P, Fischer M, Hucho T, Peifer M, Ziv Y, Reinhardt HC, Wieczorek D, Shiloh Y. Cell. 2019 Jan 24;176(3):505-519.e22. doi: 10.1016/j.cell.2018.11.024. Epub 2019 Jan 3. PubMed |
| Chromodomain Helicase DNA-Binding Protein 7 Is Suppressed in the Perinecrotic/Ischemic Microenvironment and Is a Novel Regulator of Glioblastoma Angiogenesis. Boyd NH, Walker K, Ayokanmbi A, Gordon ER, Whetsel J, Smith CM, Sanchez RG, Lubin FD, Chakraborty A, Tran AN, Herting C, Hambardzumyan D, Yancey Gillespie G, Hackney JR, Cooper SJ, Jiao K, Hjelmeland AB. Stem Cells. 2019 Apr;37(4):453-462. doi: 10.1002/stem.2969. Epub 2019 Jan 24. PubMed |
| The RNA-Binding Protein PUM2 Impairs Mitochondrial Dynamics and Mitophagy During Aging. D'Amico D, Mottis A, Potenza F, Sorrentino V, Li H, Romani M, Lemos V, Schoonjans K, Zamboni N, Knott G, Schneider BL, Auwerx J. Mol Cell. 2019 Feb 21;73(4):775-787.e10. doi: 10.1016/j.molcel.2018.11.034. Epub 2019 Jan 11. PubMed |
| Exploitation of nuclear protein SFPQ by the encephalomyocarditis virus to facilitate its replication. Zhou B, Wu F, Han J, Qi F, Ni T, Qian F. Biochem Biophys Res Commun. 2019 Feb 26;510(1):65-71. doi: 10.1016/j.bbrc.2019.01.032. Epub 2019 Jan 18. PubMed |
| Pharmacological Targeting of STK19 Inhibits Oncogenic NRAS-Driven Melanomagenesis. Yin C, Zhu B, Zhang T, Liu T, Chen S, Liu Y, Li X, Miao X, Li S, Mi X, Zhang J, Li L, Wei G, Xu ZX, Gao X, Huang C, Wei Z, Goding CR, Wang P, Deng X, Cui R. Cell. 2019 Feb 21;176(5):1113-1127.e16. doi: 10.1016/j.cell.2019.01.002. Epub 2019 Jan 31. PubMed |
| Protein kinase Calpha-mediated phosphorylation of Twist1 at Ser-144 prevents Twist1 ubiquitination and stabilizes it. Tedja R, Roberts CM, Alvero AB, Cardenas C, Yang-Hartwich Y, Spadinger S, Pitruzzello M, Yin G, Glackin CA, Mor G. J Biol Chem. 2019 Mar 29;294(13):5082-5093. doi: 10.1074/jbc.RA118.005921. Epub 2019 Feb 7. PubMed |
| Development of a non-radioactive screening assay to detect chemicals disrupting the human sodium iodide symporter activity. Dong H, Atlas E, Wade MG. Toxicol In Vitro. 2019 Jun;57:39-47. doi: 10.1016/j.tiv.2019.01.021. Epub 2019 Feb 7. PubMed |
| Andrographolide Enhances TRAIL-Induced Apoptosis via p53-Mediated Death Receptors Up-Regulation and Suppression of the NF-small ka, CyrillicB Pathway in Bladder Cancer Cells. Deng Y, Bi R, Guo H, Yang J, Du Y, Wang C, Wei W. Int J Biol Sci. 2019 Jan 24;15(3):688-700. doi: 10.7150/ijbs.30847. eCollection 2019. PubMed |
| Canthin-6-One Accelerates Alpha-Synuclein Degradation by Enhancing UPS Activity: Drug Target Identification by CRISPR-Cas9 Whole Genome-Wide Screening Technology. Yuan NN, Cai CZ, Wu MY, Zhu Q, Su H, Li M, Ren J, Tan JQ, Lu JH. Front Pharmacol. 2019 Jan 28;10:16. doi: 10.3389/fphar.2019.00016. eCollection 2019. PubMed |
| ORAI1 and ORAI3 in Breast Cancer Molecular Subtypes and the Identification of ORAI3 as a Hypoxia Sensitive Gene and a Regulator of Hypoxia Responses. Azimi I, Milevskiy MJG, Chalmers SB, Yapa KTDS, Robitaille M, Henry C, Baillie GJ, Thompson EW, Roberts-Thomson SJ, Monteith GR. Cancers (Basel). 2019 Feb 11;11(2). pii: cancers11020208. doi: 10.3390/cancers11020208. PubMed |
| ETS1 is coexpressed with ZEB2 and mediates ZEB2-induced epithelial-mesenchymal transition in human tumors. Yalim-Camci I, Balcik-Ercin P, Cetin M, Odabas G, Tokay N, Sayan AE, Yagci T. Mol Carcinog. 2019 Jun;58(6):1068-1081. doi: 10.1002/mc.22994. Epub 2019 Mar 6. PubMed |
| MST1 Suppresses Pancreatic Cancer Progression via ROS-Induced Pyroptosis. Cui J, Zhou Z, Yang H, Jiao F, Li N, Gao Y, Wang L, Chen J, Quan M. Mol Cancer Res. 2019 Jun;17(6):1316-1325. doi: 10.1158/1541-7786.MCR-18-0910. Epub 2019 Feb 22. PubMed |
| Base editing the mammalian genome. Schatoff EM, Zafra MP, Dow LE. Methods. 2019 Jul 15;164-165:100-108. doi: 10.1016/j.ymeth.2019.02.022. Epub 2019 Mar 2. PubMed |
| FMR1 Reactivating Treatments in Fragile X iPSC-Derived Neural Progenitors In Vitro and In Vivo. Vershkov D, Fainstein N, Suissa S, Golan-Lev T, Ben-Hur T, Benvenisty N. Cell Rep. 2019 Mar 5;26(10):2531-2539.e4. doi: 10.1016/j.celrep.2019.02.026. PubMed |
| Genome-wide screening identifies novel genes and biological processes implicated in cisplatin resistance. Ko T, Li S. FASEB J. 2019 Jun;33(6):7143-7154. doi: 10.1096/fj.201801534RR. Epub 2019 Mar 7. PubMed |
| Ribosomal protein RPL22/eL22 regulates the cell cycle by acting as an inhibitor of the CDK4-cyclin D complex. Del Toro N, Fernandez-Ruiz A, Mignacca L, Kalegari P, Rowell MC, Igelmann S, Saint-Germain E, Benfdil M, Lopes-Paciencia S, Brakier-Gingras L, Bourdeau V, Ferbeyre G, Lessard F. Cell Cycle. 2019 Mar - Apr;18(6-7):759-770. doi: 10.1080/15384101.2019.1593708. Epub 2019 Mar 28. PubMed |
| Assessment of different strategies for scalable production and proliferation of human myoblasts. Chua MJ, Yildirim ED, Tan JE, Chua YB, Low SC, Ding SLS, Li CW, Jiang Z, Teh BT, Yu K, Shyh-Chang N. Cell Prolif. 2019 May;52(3):e12602. doi: 10.1111/cpr.12602. Epub 2019 Mar 19. PubMed |
| Negative Regulation of p53-Induced Senescence by N-WASP Is Crucial for DMBA/TPA-Induced Skin Tumor Formation. Li H, Petersen S, Garcia Mariscal A, Brakebusch C. Cancer Res. 2019 May 1;79(9):2167-2181. doi: 10.1158/0008-5472.CAN-18-1253. Epub 2019 Mar 20. PubMed |
A reference collection of patient-derived cell line and xenograft models of proneural, classical and mesenchymal glioblastoma.
Stringer BW, Day BW, D'Souza RCJ, Jamieson PR, Ensbey KS, Bruce ZC, Lim YC, Goasdoue K, Offenhauser C, Akgul S, Allan S, Robertson T, Lucas P, Tollesson G, Campbell S, Winter C, Do H, Dobrovic A, Inglis PL, Jeffree RL, Johns TG, Boyd AW.
Sci Rep. 2019 Mar 20;9(1):4902. doi: 10.1038/s41598-019-41277-z.
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| A Systematic Pan-Cancer Analysis of Genetic Heterogeneity Reveals Associations with Epigenetic Modifiers. de Matos MR, Posa I, Carvalho FS, Morais VA, Grosso AR, de Almeida SF. Cancers (Basel). 2019 Mar 20;11(3). pii: cancers11030391. doi: 10.3390/cancers11030391. PubMed |
| Mutant p53 regulates LPA signaling through lysophosphatidic acid phosphatase type 6. Chryplewicz A, Tienda SM, Nahotko DA, Peters PN, Lengyel E, Eckert MA. Sci Rep. 2019 Mar 26;9(1):5195. doi: 10.1038/s41598-019-41352-5. PubMed |
| Myristoylated alanine-rich C-kinase substrate effector domain phosphorylation regulates the growth and radiation sensitization of glioblastoma. Eustace NJ, Anderson JC, Langford CP, Trummell HQ, Hicks PH, Jarboe JS, Mobley JA, Hjelmeland AB, Hackney JR, Pedersen RT, Cosby K, Gillespie GY, Bonner JA, Willey CD. Int J Oncol. 2019 Jun;54(6):2039-2053. doi: 10.3892/ijo.2019.4766. Epub 2019 Mar 29. PubMed |
| ATG2 transports lipids to promote autophagosome biogenesis. Valverde DP, Yu S, Boggavarapu V, Kumar N, Lees JA, Walz T, Reinisch KM, Melia TJ. J Cell Biol. 2019 Jun 3;218(6):1787-1798. doi: 10.1083/jcb.201811139. Epub 2019 Apr 5. PubMed |
| Bok regulates mitochondrial fusion and morphology. Schulman JJ, Szczesniak LM, Bunker EN, Nelson HA, Roe MW, Wagner LE 2nd, Yule DI, Wojcikiewicz RJH. Cell Death Differ. 2019 Dec;26(12):2682-2694. doi: 10.1038/s41418-019-0327-4. Epub 2019 Apr 11. PubMed |
| Oleic acid-induced defective autolysosome shows impaired lipid degradation. Lee DH, Ahn J, Jang YJ, Ha TY, Jung CH. Biochem Biophys Res Commun. 2019 Jun 4;513(3):553-559. doi: 10.1016/j.bbrc.2019.04.040. Epub 2019 Apr 10. PubMed |
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| Visualizing Engrafted Human Cancer and Therapy Responses in Immunodeficient Zebrafish. Yan C, Brunson DC, Tang Q, Do D, Iftimia NA, Moore JC, Hayes MN, Welker AM, Garcia EG, Dubash TD, Hong X, Drapkin BJ, Myers DT, Phat S, Volorio A, Marvin DL, Ligorio M, Dershowitz L, McCarthy KM, Karabacak MN, Fletcher JA, Sgroi DC, Iafrate JA, Maheswaran S, Dyson NJ, Haber DA, Rawls JF, Langenau DM. Cell. 2019 Jun 13;177(7):1903-1914.e14. doi: 10.1016/j.cell.2019.04.004. Epub 2019 Apr 25. PubMed |
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An AND-Gated Drug and Photoactivatable Cre-loxP System for Spatiotemporal Control in Cell-Based Therapeutics.
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A quantitative single-cell assay for retrograde membrane traffic enables rapid detection of defects in cellular organization.
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| The Roles of GSK-3beta in Regulation of Retinoid Signaling and Sorafenib Treatment Response in Hepatocellular Carcinoma. Zhang S, Gao W, Tang J, Zhang H, Zhou Y, Liu J, Chen K, Liu F, Li W, To SKY, Wong AST, Zhang XK, Zhou H, Zeng JZ. Theranostics. 2020 Jan 1;10(3):1230-1244. doi: 10.7150/thno.38711. eCollection 2020. PubMed |
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| p53 controls genomic stability and temporal differentiation of human neural stem cells and affects neural organization in human brain organoids. Marin Navarro A, Pronk RJ, van der Geest AT, Oliynyk G, Nordgren A, Arsenian-Henriksson M, Falk A, Wilhelm M. Cell Death Dis. 2020 Jan 23;11(1):52. doi: 10.1038/s41419-019-2208-7. PubMed |
| c-Src Phosphorylates and Inhibits the Function of the CIC Tumor Suppressor Protein. Bunda S, Heir P, Li ASC, Mamatjan Y, Zadeh G, Aldape K. Mol Cancer Res. 2020 May;18(5):774-786. doi: 10.1158/1541-7786.MCR-18-1370. Epub 2020 Feb 6. PubMed |
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| Iridoids of Valeriana fauriei contribute to alleviating hepatic steatosis in obese mice by lipophagy. Lee DH, Park SH, Huh YH, Jung Kim M, Seo HD, Ha TY, Ahn J, Jang YJ, Jung CH. Biomed Pharmacother. 2020 May;125:109950. doi: 10.1016/j.biopha.2020.109950. Epub 2020 Feb 10. PubMed |
Chemogenetic Control of Nanobodies.
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| Functional angiogenesis requires microenvironmental cues balancing endothelial cell migration and proliferation. Wang WY, Lin D, Jarman EH, Polacheck WJ, Baker BM. Lab Chip. 2020 Mar 17;20(6):1153-1166. doi: 10.1039/c9lc01170f. PubMed |
| KLF16 Affects the MYC Signature and Tumor Growth in Prostate Cancer. Zhang J, Yu W, Wang X, Hu B, Wu D, Shi G. Onco Targets Ther. 2020 Feb 13;13:1303-1310. doi: 10.2147/OTT.S233495. eCollection 2020. PubMed |
| Acute knockdown of Depdc5 leads to synaptic defects in mTOR-related epileptogenesis. De Fusco A, Cerullo MS, Marte A, Michetti C, Romei A, Castroflorio E, Baulac S, Benfenati F. Neurobiol Dis. 2020 Jun;139:104822. doi: 10.1016/j.nbd.2020.104822. Epub 2020 Feb 27. PubMed |
Accurate and live peroxisome biogenesis evaluation achieved by lentiviral expression of a green fluorescent protein fused to a peroxisome targeting signal 1.
Demaret T, Courtoy GE, Ravau J, Van Der Smissen P, Najimi M, Sokal EM.
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| Prioritizing disease and trait causal variants at the TNFAIP3 locus using functional and genomic features. Ray JP, de Boer CG, Fulco CP, Lareau CA, Kanai M, Ulirsch JC, Tewhey R, Ludwig LS, Reilly SK, Bergman DT, Engreitz JM, Issner R, Finucane HK, Lander ES, Regev A, Hacohen N. Nat Commun. 2020 Mar 6;11(1):1237. doi: 10.1038/s41467-020-15022-4. PubMed |
| Biallelic loss of FAM46C triggers tumor growth with concomitant activation of Akt signaling in multiple myeloma cells. Kanasugi J, Hanamura I, Ota A, Karnan S, Lam VQ, Mizuno S, Wahiduzzaman M, Rahman ML, Hyodo T, Konishi H, Tsuzuki S, Hosokawa Y, Takami A. Cancer Sci. 2020 May;111(5):1663-1675. doi: 10.1111/cas.14386. Epub 2020 Apr 9. PubMed |
| Improved detection of differentially represented DNA barcodes for high-throughput clonal phenomics. Akimov Y, Bulanova D, Timonen S, Wennerberg K, Aittokallio T. Mol Syst Biol. 2020 Mar;16(3):e9195. doi: 10.15252/msb.20199195. PubMed |
| Nicotinamide nucleotide transhydrogenase regulates mitochondrial metabolism in NSCLC through maintenance of Fe-S protein function. Ward NP, Kang YP, Falzone A, Boyle TA, DeNicola GM. J Exp Med. 2020 Jun 1;217(6). pii: 151572. doi: 10.1084/jem.20191689. PubMed |
| Complement-Independent Modulation of Influenza A Virus Infection by Factor H. Murugaiah V, Varghese PM, Saleh SM, Tsolaki AG, Alrokayan SH, Khan HA, Collison KS, Sim RB, Nal B, Al-Mohanna FA, Kishore U. Front Immunol. 2020 Mar 25;11:355. doi: 10.3389/fimmu.2020.00355. eCollection 2020. PubMed |
| Inhibition of collagen XI alpha 1-induced fatty acid oxidation triggers apoptotic cell death in cisplatin-resistant ovarian cancer. Nallanthighal S, Rada M, Heiserman JP, Cha J, Sage J, Zhou B, Yang W, Hu Y, Korgaonkar C, Hanos CT, Ashkavand Z, Norman K, Orsulic S, Cheon DJ. Cell Death Dis. 2020 Apr 20;11(4):258. doi: 10.1038/s41419-020-2442-z. PubMed |
| HIGD2A is Required for Assembly of the COX3 Module of Human Mitochondrial Complex IV. Hock DH, Reljic B, Ang CS, Muellner-Wong L, Mountford HS, Compton AG, Ryan MT, Thorburn DR, Stroud DA. Mol Cell Proteomics. 2020 Jul;19(7):1145-1160. doi: 10.1074/mcp.RA120.002076. Epub 2020 Apr 21. PubMed |
| CtBP determines ovarian cancer cell fate through repression of death receptors. Ding B, Yuan F, Damle PK, Litovchick L, Drapkin R, Grossman SR. Cell Death Dis. 2020 Apr 24;11(4):286. doi: 10.1038/s41419-020-2455-7. PubMed |
| Trichoplein binds PCM1 and controls endothelial cell function by regulating autophagy. Martello A, Lauriola A, Mellis D, Parish E, Dawson JC, Imrie L, Vidmar M, Gammoh N, Mitic T, Brittan M, Mills NL, Carragher NO, D'Arca D, Caporali A. EMBO Rep. 2020 Jul 3;21(7):e48192. doi: 10.15252/embr.201948192. Epub 2020 Apr 26. PubMed |
| Nelfinavir Inhibits the TCF11/Nrf1-Mediated Proteasome Recovery Pathway in Multiple Myeloma. Fassmannova D, Sedlak F, Sedlacek J, Spicka I, Grantz Saskova K. Cancers (Basel). 2020 Apr 25;12(5). pii: cancers12051065. doi: 10.3390/cancers12051065. PubMed |
| BCL9/STAT3 regulation of transcriptional enhancer networks promote DCIS progression. Elsarraj HS, Hong Y, Limback D, Zhao R, Berger J, Bishop SC, Sabbagh A, Oppenheimer L, Harper HE, Tsimelzon A, Huang S, Hilsenbeck SG, Edwards DP, Fontes J, Fan F, Madan R, Fangman B, Ellis A, Tawfik O, Persons DL, Fields T, Godwin AK, Hagan CR, Swenson-Fields K, Coarfa C, Thompson J, Behbod F. NPJ Breast Cancer. 2020 Apr 24;6:12. doi: 10.1038/s41523-020-0157-z. eCollection 2020. PubMed |
| Photoactivatable Cre recombinase 3.0 for in vivo mouse applications. Morikawa K, Furuhashi K, de Sena-Tomas C, Garcia-Garcia AL, Bekdash R, Klein AD, Gallerani N, Yamamoto HE, Park SE, Collins GS, Kawano F, Sato M, Lin CS, Targoff KL, Au E, Salling MC, Yazawa M. Nat Commun. 2020 May 1;11(1):2141. doi: 10.1038/s41467-020-16030-0. PubMed |
| Formate induces a metabolic switch in nucleotide and energy metabolism. Oizel K, Tait-Mulder J, Fernandez-de-Cossio-Diaz J, Pietzke M, Brunton H, Lilla S, Dhayade S, Athineos D, Blanco GR, Sumpton D, Mackay GM, Blyth K, Zanivan SR, Meiser J, Vazquez A. Cell Death Dis. 2020 May 4;11(5):310. doi: 10.1038/s41419-020-2523-z. PubMed |
| Epithelial cell -derived microvesicles: A safe delivery platform of CRISPR/Cas9 conferring synergistic anti-tumor effect with sorafenib. He C, Jaffar Ali D, Xu H, Kumaravel S, Si K, Li Y, Sun B, Ma J, Xiao Z. Exp Cell Res. 2020 Jul 15;392(2):112040. doi: 10.1016/j.yexcr.2020.112040. Epub 2020 May 4. PubMed |
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| A beta-Catenin-TCF-Sensitive Locus Control Region Mediates GUCY2C Ligand Loss in Colorectal Cancer. Rappaport JA, Entezari AA, Caspi A, Caksa S, Jhaveri AV, Stanek TJ, Ertel A, Kupper J, Fortina PM, McMahon SB, Jaynes JB, Snook AE, Waldman SA. Cell Mol Gastroenterol Hepatol. 2022;13(4):1276-1296. doi: 10.1016/j.jcmgh.2021.12.014. Epub 2021 Dec 22. PubMed |
| Epigenetic regulation of ferroptosis via ETS1/miR-23a-3p/ACSL4 axis mediates sorafenib resistance in human hepatocellular carcinoma. Lu Y, Chan YT, Tan HY, Zhang C, Guo W, Xu Y, Sharma R, Chen ZS, Zheng YC, Wang N, Feng Y. J Exp Clin Cancer Res. 2022 Jan 3;41(1):3. doi: 10.1186/s13046-021-02208-x. PubMed |
| SUMOylation inhibition enhances dexamethasone sensitivity in multiple myeloma. Du L, Liu W, Aldana-Masangkay G, Pozhitkov A, Pichiorri F, Chen Y, Rosen ST. J Exp Clin Cancer Res. 2022 Jan 4;41(1):8. doi: 10.1186/s13046-021-02226-9. PubMed |
| Restriction of extracellular lipids renders pancreatic cancer dependent on autophagy. Saliakoura M, Sebastiano MR, Nikdima I, Pozzato C, Konstantinidou G. J Exp Clin Cancer Res. 2022 Jan 8;41(1):16. doi: 10.1186/s13046-021-02231-y. PubMed |
| Targeting the Fusion Process of SARS-CoV-2 Infection by Small Molecule Inhibitors. Park SB, Irvin P, Hu Z, Khan M, Hu X, Zeng Q, Chen C, Xu M, Leek M, Zang R, Case JB, Zheng W, Ding S, Liang TJ. mBio. 2022 Feb 22;13(1):e0323821. doi: 10.1128/mbio.03238-21. Epub 2022 Jan 11. PubMed |
| PHY34 inhibits autophagy through V-ATPase V0A2 subunit inhibition and CAS/CSE1L nuclear cargo trafficking in high grade serous ovarian cancer. Salvi A, Young AN, Huntsman AC, Pergande MR, Korkmaz MA, Rathnayake RA, Mize BK, Kinghorn AD, Zhang X, Ratia K, Schirle M, Thomas JR, Brittain SM, Shelton C, Aldrich LN, Cologna SM, Fuchs JR, Burdette JE. Cell Death Dis. 2022 Jan 10;13(1):45. doi: 10.1038/s41419-021-04495-w. PubMed |
| Lysoptosis is an evolutionarily conserved cell death pathway moderated by intracellular serpins. Luke CJ, Markovina S, Good M, Wight IE, Thomas BJ, Linneman JM, Lanik WE, Koroleva O, Coffman MR, Miedel MT, Gong Q, Andress A, Campos Guerrero M, Wang S, Chen L, Beatty WL, Hausmann KN, White FV, Fitzpatrick JAJ, Orvedahl A, Pak SC, Silverman GA. Commun Biol. 2022 Jan 12;5(1):47. doi: 10.1038/s42003-021-02953-x. PubMed |
| The Immune-Specific E3 Ubiquitin Ligase MARCH1 Is Upregulated during Human Cytomegalovirus Infection to Regulate Iron Levels. Martin M, Sandhu P, Kumar R, Buchkovich NJ. J Virol. 2022 Mar 23;96(6):e0180621. doi: 10.1128/jvi.01806-21. Epub 2022 Jan 19. PubMed |
Engineering T-Cell Resistance to HIV-1 Infection via Knock-In of Peptides from the Heptad Repeat 2 Domain of gp41.
Maslennikova A, Kruglova N, Kalinichenko S, Komkov D, Shepelev M, Golubev D, Siniavin A, Vzorov A, Filatov A, Mazurov D.
mBio. 2022 Jan 25:e0358921. doi: 10.1128/mbio.03589-21.
PubMed
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| ER stress-induced cell death proceeds independently of the TRAIL-R2 signaling axis in pancreatic beta cells. Hagenlocher C, Siebert R, Taschke B, Wieske S, Hausser A, Rehm M. Cell Death Discov. 2022 Jan 24;8(1):34. doi: 10.1038/s41420-022-00830-y. PubMed |
| Disruption of actin dynamics induces autophagy of the eukaryotic chaperonin TRiC/CCT. Date Y, Matsuura A, Itakura E. Cell Death Discov. 2022 Jan 25;8(1):37. doi: 10.1038/s41420-022-00828-6. PubMed |
| De novo expression of gastrokines in pancreatic precursor lesions impede the development of pancreatic cancer. Steiner S, Seleznik GM, Reding T, Stopic M, Lenggenhager D, Ten Buren E, Eshmuminov D, Endhardt K, Hagedorn C, Heidenblut AM, Bratus-Neuenschwander A, Grossmann J, Trachsel C, Jabbar KS, Hahn SA, Berg JV, Graf R, Gupta A. Oncogene. 2022 Mar;41(10):1507-1517. doi: 10.1038/s41388-022-02182-4. Epub 2022 Jan 26. PubMed |
| Aberrant expression of claudin-6 contributes to malignant potentials and drug resistance of cervical adenocarcinoma. Ito Y, Takasawa A, Takasawa K, Murakami T, Akimoto T, Kyuno D, Kawata Y, Shano K, Kirisawa K, Ota M, Aoyama T, Murata M, Sugimoto K, Chiba H, Saito T, Osanai M. Cancer Sci. 2022 Apr;113(4):1519-1530. doi: 10.1111/cas.15284. Epub 2022 Feb 13. PubMed |
| Inhibition of Orai Channel Function Regulates Mas-Related G Protein-Coupled Receptor-Mediated Responses in Mast Cells. Chaki S, Alkanfari I, Roy S, Amponnawarat A, Hui Y, Oskeritzian CA, Ali H. Front Immunol. 2022 Jan 20;12:803335. doi: 10.3389/fimmu.2021.803335. eCollection 2021. PubMed |
| A human antibody reveals a conserved site on beta-coronavirus spike proteins and confers protection against SARS-CoV-2 infection. Zhou P, Yuan M, Song G, Beutler N, Shaabani N, Huang D, He WT, Zhu X, Callaghan S, Yong P, Anzanello F, Peng L, Ricketts J, Parren M, Garcia E, Rawlings SA, Smith DM, Nemazee D, Teijaro JR, Rogers TF, Wilson IA, Burton DR, Andrabi R. Sci Transl Med. 2022 Mar 23;14(637):eabi9215. doi: 10.1126/scitranslmed.abi9215. Epub 2022 Mar 23. PubMed |
| Pathway-specific effects of ADSL deficiency on neurodevelopment. Dutto I, Gerhards J, Herrera A, Souckova O, Skopova V, Smak JA, Junza A, Yanes O, Boeckx C, Burkhalter MD, Zikanova M, Pons S, Philipp M, Luders J, Stracker TH. Elife. 2022 Feb 8;11. pii: 70518. doi: 10.7554/eLife.70518. PubMed |
| A protease-activatable luminescent biosensor and reporter cell line for authentic SARS-CoV-2 infection. Gerber PP, Duncan LM, Greenwood EJ, Marelli S, Naamati A, Teixeira-Silva A, Crozier TW, Gabaev I, Zhan JR, Mulroney TE, Horner EC, Doffinger R, Willis AE, Thaventhiran JE, Protasio AV, Matheson NJ. PLoS Pathog. 2022 Feb 10;18(2):e1010265. doi: 10.1371/journal.ppat.1010265. eCollection 2022 Feb. PubMed |
| DNA methyltransferase 1 (DNMT1) suppresses mitophagy and aggravates heart failure via the microRNA-152-3p/ETS1/RhoH axis. Deng Z, Yao J, Xiao N, Han Y, Wu X, Ci C, Chen K, Geng X. Lab Invest. 2022 Aug;102(8):782-793. doi: 10.1038/s41374-022-00740-8. Epub 2022 Feb 11. PubMed |
| Ferritin-Nanocaged ATP Traverses the Blood-Testis Barrier and Enhances Sperm Motility in an Asthenozoospermia Model. Pang J, Feng X, Liang Q, Zheng X, Duan Y, Zhang X, Zhang J, Chen Y, Fan K, Gao L, Li J. ACS Nano. 2022 Mar 22;16(3):4175-4185. doi: 10.1021/acsnano.1c10029. Epub 2022 Feb 15. PubMed |
| CHCHD2 and CHCHD10 regulate mitochondrial dynamics and integrated stress response. Ruan Y, Hu J, Che Y, Liu Y, Luo Z, Cheng J, Han Q, He H, Zhou Q. Cell Death Dis. 2022 Feb 16;13(2):156. doi: 10.1038/s41419-022-04602-5. PubMed |
| Circular RNA ANAPC7 Inhibits Tumor Growth and Muscle Wasting via PHLPP2-AKT-TGF-beta Signaling Axis in Pancreatic Cancer. Shi X, Yang J, Liu M, Zhang Y, Zhou Z, Luo W, Fung KM, Xu C, Bronze MS, Houchen CW, Li M. Gastroenterology. 2022 Jun;162(7):2004-2017.e2. doi: 10.1053/j.gastro.2022.02.017. Epub 2022 Feb 14. PubMed |
| PKP1 and MYC create a feedforward loop linking transcription and translation in squamous cell lung cancer. Boyero L, Martin-Padron J, Farez-Vidal ME, Rodriguez MI, Andrades A, Peinado P, Arenas AM, Ritore-Salazar F, Alvarez-Perez JC, Cuadros M, Medina PP. Cell Oncol (Dordr). 2022 Apr;45(2):323-332. doi: 10.1007/s13402-022-00660-1. Epub 2022 Feb 19. PubMed |
| P2Y1 purinergic receptor identified as a diabetes target in a small-molecule screen to reverse circadian beta-cell failure. Marcheva B, Weidemann BJ, Taguchi A, Perelis M, Ramsey KM, Newman MV, Kobayashi Y, Omura C, Manning Fox JE, Lin H, Macdonald PE, Bass J. Elife. 2022 Feb 21;11. pii: 75132. doi: 10.7554/eLife.75132. PubMed |
| A novel mechanism for NLRP3 inflammasome activation. Zhang T, Zhao J, Liu T, Cheng W, Wang Y, Ding S, Wang R. Metabol Open. 2022 Jan 22;13:100166. doi: 10.1016/j.metop.2022.100166. eCollection 2022 Mar. PubMed |
| The Solute Carrier MFSD1 Decreases the Activation Status of beta1 Integrin and Thus Tumor Metastasis. Roblek M, Bicher J, van Gogh M, Gyorgy A, Seebock R, Szulc B, Damme M, Olczak M, Borsig L, Siekhaus DE. Front Oncol. 2022 Feb 8;12:777634. doi: 10.3389/fonc.2022.777634. eCollection 2022. PubMed |
| Discovery of a potent cytotoxic agent that promotes G2/M phase cell cycle arrest and apoptosis in a malignant human pharyngeal squamous carcinoma cell line. Nuth M, Benakanakere MR, Ricciardi RP. Int J Oncol. 2022 Apr;60(4). pii: 41. doi: 10.3892/ijo.2022.5331. Epub 2022 Feb 25. PubMed |
| YAP regulates an SGK1/mTORC1/SREBP-dependent lipogenic program to support proliferation and tissue growth. Vaidyanathan S, Salmi TM, Sathiqu RM, McConville MJ, Cox AG, Brown KK. Dev Cell. 2022 Mar 28;57(6):719-731.e8. doi: 10.1016/j.devcel.2022.02.004. Epub 2022 Feb 24. PubMed |
LKB1 drives stasis and C/EBP-mediated reprogramming to an alveolar type II fate in lung cancer.
Murray CW, Brady JJ, Han M, Cai H, Tsai MK, Pierce SE, Cheng R, Demeter J, Feldser DM, Jackson PK, Shackelford DB, Winslow MM.
Nat Commun. 2022 Feb 28;13(1):1090. doi: 10.1038/s41467-022-28619-8.
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| Confined migration promotes cancer metastasis through resistance to anoikis and increased invasiveness. Fanfone D, Wu Z, Mammi J, Berthenet K, Neves D, Weber K, Halaburkova A, Virard F, Bunel F, Jamard C, Hernandez-Vargas H, Tait SWG, Hennino A, Ichim G. Elife. 2022 Mar 8;11. pii: 73150. doi: 10.7554/eLife.73150. PubMed |
| Novel mutation of SIK1 gene causing a mild form of pediatric epilepsy in a Chinese patient. Xu W, Zhang W, Cui L, Shi L, Zhu B, Lyu TJ, Ma W. Metab Brain Dis. 2022 Apr;37(4):1207-1219. doi: 10.1007/s11011-022-00943-4. Epub 2022 Mar 10. PubMed |
| TRIM24 promotes colorectal cancer cell progression via the Wnt/beta-catenin signaling pathway activation. Tian H, Zhao H, Qu B, Chu X, Xin X, Zhang Q, Li W, Yang S. Am J Transl Res. 2022 Feb 15;14(2):831-848. eCollection 2022. PubMed |
| H-ABC- and dystonia-causing TUBB4A mutations show distinct pathogenic effects. Krajka V, Vulinovic F, Genova M, Tanzer K, Jijumon AS, Bodakuntla S, Tennstedt S, Mueller-Fielitz H, Meier B, Janke C, Klein C, Rakovic A. Sci Adv. 2022 Mar 11;8(10):eabj9229. doi: 10.1126/sciadv.abj9229. Epub 2022 Mar 11. PubMed |
| Muller glia fused with adult stem cells undergo neural differentiation in human retinal models. Bonilla-Pons SA, Nakagawa S, Bahima EG, Fernandez-Blanco A, Pesaresi M, D'Antin JC, Sebastian-Perez R, Greco D, Dominguez-Sala E, Gomez-Riera R, Compte RIB, Dierssen M, Pulido NM, Cosma MP. EBioMedicine. 2022 Mar;77:103914. doi: 10.1016/j.ebiom.2022.103914. Epub 2022 Mar 9. PubMed |
Benchmarking of SpCas9 variants enables deeper base editor screens of BRCA1 and BCL2.
Sangree AK, Griffith AL, Szegletes ZM, Roy P, DeWeirdt PC, Hegde M, McGee AV, Hanna RE, Doench JG.
Nat Commun. 2022 Mar 14;13(1):1318. doi: 10.1038/s41467-022-28884-7.
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| Immunoaffinity Purification of Epitope-Tagged DNA Repair Complexes from Human Cells. Townley BA, Soll JM, Mosammaparast N. Methods Mol Biol. 2022;2444:29-41. doi: 10.1007/978-1-0716-2063-2_3. PubMed |
Broadly neutralizing anti-S2 antibodies protect against all three human betacoronaviruses that cause deadly disease.
Zhou P, Song G, Liu H, Yuan M, He WT, Beutler N, Zhu X, Tse LV, Martinez DR, Schafer A, Anzanello F, Yong P, Peng L, Dueker K, Musharrafieh R, Callaghan S, Capozzola T, Limbo O, Parren M, Garcia E, Rawlings SA, Smith DM, Nemazee D, Jardine JG, Safonova Y, Briney B, Rogers TF, Wilson IA, Baric RS, Gralinski LE, Burton DR, Andrabi R.
Immunity. 2023 Mar 14;56(3):669-686.e7. doi: 10.1016/j.immuni.2023.02.005. Epub 2023 Feb 16.
PubMed
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In vivo prime editing of a metabolic liver disease in mice.
Bock D, Rothgangl T, Villiger L, Schmidheini L, Matsushita M, Mathis N, Ioannidi E, Rimann N, Grisch-Chan HM, Kreutzer S, Kontarakis Z, Kopf M, Thony B, Schwank G.
Sci Transl Med. 2022 Mar 16;14(636):eabl9238. doi: 10.1126/scitranslmed.abl9238. Epub 2022 Mar 16.
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| VIVA1: a more invasive subclone of MDA-MB-134VI invasive lobular carcinoma cells with increased metastatic potential in xenograft models. Allen V, Coulombe J, Zhao H, Kreps LM, Cook DP, Pryce B, Clemons M, Vanderhyden BC, Gray DA, Addison CL. Br J Cancer. 2022 Jul;127(1):56-68. doi: 10.1038/s41416-022-01778-7. Epub 2022 Mar 22. PubMed |
| Orthogonally induced differentiation of stem cells for the programmatic patterning of vascularized organoids and bioprinted tissues. Skylar-Scott MA, Huang JY, Lu A, Ng AHM, Duenki T, Liu S, Nam LL, Damaraju S, Church GM, Lewis JA. Nat Biomed Eng. 2022 Apr;6(4):449-462. doi: 10.1038/s41551-022-00856-8. Epub 2022 Mar 24. PubMed |
| Crystal structure and cellular functions of uPAR dimer. Yu S, Sui Y, Wang J, Li Y, Li H, Cao Y, Chen L, Jiang L, Yuan C, Huang M. Nat Commun. 2022 Mar 29;13(1):1665. doi: 10.1038/s41467-022-29344-y. PubMed |
| Dual-gRNA approach with limited off-target effect corrects C9ORF72 repeat expansion in vivo. Piao X, Meng D, Zhang X, Song Q, Lv H, Jia Y. Sci Rep. 2022 Apr 5;12(1):5672. doi: 10.1038/s41598-022-07746-8. PubMed |
| Enhanced anti-angiogenetic effect of transferrin receptor-mediated delivery of VEGF-trap in a glioblastoma mouse model. Zhao P, Anami Y, Gao P, Fan X, Li L, Tsuchikama K, Zhang N, An Z. MAbs. 2022 Jan-Dec;14(1):2057269. doi: 10.1080/19420862.2022.2057269. PubMed |
| A Novel Sushi-IL15-PD1 CAR-NK92 Cell Line With Enhanced and PD-L1 Targeted Cytotoxicity Against Pancreatic Cancer Cells. Xu DL, He YQ, Xiao B, Si Y, Shi J, Liu XA, Tian L, Ren Q, Wu YS, Zhu Y. Front Oncol. 2022 Mar 22;12:726985. doi: 10.3389/fonc.2022.726985. eCollection 2022. PubMed |
| When killers become thieves: Trogocytosed PD-1 inhibits NK cells in cancer. Hasim MS, Marotel M, Hodgins JJ, Vulpis E, Makinson OJ, Asif S, Shih HY, Scheer AK, MacMillan O, Alonso FG, Burke KP, Cook DP, Li R, Petrucci MT, Santoni A, Fallon PG, Sharpe AH, Sciume G, Veillette A, Zingoni A, Gray DA, McCurdy A, Ardolino M. Sci Adv. 2022 Apr 15;8(15):eabj3286. doi: 10.1126/sciadv.abj3286. Epub 2022 Apr 13. PubMed |
| The nuclear lamina binds the EBV genome during latency and regulates viral gene expression. Caruso LB, Guo R, Keith K, Madzo J, Maestri D, Boyle S, Wasserman J, Kossenkov A, Gewurz BE, Tempera I. PLoS Pathog. 2022 Apr 14;18(4):e1010400. doi: 10.1371/journal.ppat.1010400. eCollection 2022 Apr. PubMed |
| Functional elements of the cis-regulatory lincRNA-p21. Winkler L, Jimenez M, Zimmer JT, Williams A, Simon MD, Dimitrova N. Cell Rep. 2022 Apr 19;39(3):110687. doi: 10.1016/j.celrep.2022.110687. PubMed |
| Mitochondrial dynamics regulate genome stability via control of caspase-dependent DNA damage. Cao K, Riley JS, Heilig R, Montes-Gomez AE, Vringer E, Berthenet K, Cloix C, Elmasry Y, Spiller DG, Ichim G, Campbell KJ, Gilmore AP, Tait SWG. Dev Cell. 2022 May 23;57(10):1211-1225.e6. doi: 10.1016/j.devcel.2022.03.019. Epub 2022 Apr 20. PubMed |
| Selective ferroptosis vulnerability due to familial Alzheimer's disease presenilin mutations. Greenough MA, Lane DJR, Balez R, Anastacio HTD, Zeng Z, Ganio K, McDevitt CA, Acevedo K, Belaidi AA, Koistinaho J, Ooi L, Ayton S, Bush AI. Cell Death Differ. 2022 Apr 21. pii: 10.1038/s41418-022-01003-1. doi: 10.1038/s41418-022-01003-1. PubMed |
The nuclear receptor THRB facilitates differentiation of human PSCs into more mature hepatocytes.
Ma H, de Zwaan E, Guo YE, Cejas P, Thiru P, van de Bunt M, Jeppesen JF, Syamala S, Dall'Agnese A, Abraham BJ, Fu D, Garrett-Engele C, Lee TI, Long HW, Griffith LG, Young RA, Jaenisch R.
Cell Stem Cell. 2022 Apr 13. pii: S1934-5909(22)00150-3. doi: 10.1016/j.stem.2022.03.015.
PubMed
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| Oncohistone Mutations Occur at Functional Sites of Regulatory ADP-Ribosylation. Huang D, Camacho CV, Martire S, Nagari A, Setlem R, Gong X, Edwards AD, Chiu SP, Banaszynski LA, Kraus WL. Cancer Res. 2022 Jul 5;82(13):2361-2377. doi: 10.1158/0008-5472.CAN-22-0742. PubMed |
| Genomewide CRISPR knockout screen identified PLAC8 as an essential factor for SADS-CoVs infection. Tse LV, Meganck RM, Araba KC, Yount BL, Shaffer KM, Hou YJ, Munt JE, Adams LE, Wykoff JA, Morowitz JM, Dong S, Magness ST, Marzluff WF, Gonzalez LM, Ehre C, Baric RS. Proc Natl Acad Sci U S A. 2022 May 3;119(18):e2118126119. doi: 10.1073/pnas.2118126119. Epub 2022 Apr 27. PubMed |
| ASCL1 activates neuronal stem cell-like lineage programming through remodeling of the chromatin landscape in prostate cancer. Nouruzi S, Ganguli D, Tabrizian N, Kobelev M, Sivak O, Namekawa T, Thaper D, Baca SC, Freedman ML, Aguda A, Davies A, Zoubeidi A. Nat Commun. 2022 Apr 27;13(1):2282. doi: 10.1038/s41467-022-29963-5. PubMed |
| Polarity protein SCRIB interacts with SLC3A2 to regulate proliferation and tamoxifen resistance in ER+ breast cancer. Saito Y, Matsuda S, Ohnishi N, Endo K, Ashitani S, Ohishi M, Ueno A, Tomita M, Ueda K, Soga T, Muthuswamy SK. Commun Biol. 2022 May 2;5(1):403. doi: 10.1038/s42003-022-03363-3. PubMed |
| Combinatorial GxGxE CRISPR screen identifies SLC25A39 in mitochondrial glutathione transport linking iron homeostasis to OXPHOS. Shi X, Reinstadler B, Shah H, To TL, Byrne K, Summer L, Calvo SE, Goldberger O, Doench JG, Mootha VK, Shen H. Nat Commun. 2022 May 5;13(1):2483. doi: 10.1038/s41467-022-30126-9. PubMed |
Comparative optimization of combinatorial CRISPR screens.
Li R, Klingbeil O, Monducci D, Young MJ, Rodriguez DJ, Bayyat Z, Dempster JM, Kesar D, Yang X, Zamanighomi M, Vakoc CR, Ito T, Sellers WR.
Nat Commun. 2022 May 5;13(1):2469. doi: 10.1038/s41467-022-30196-9.
PubMed
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| SARS-CoV-2 Employ BSG/CD147 and ACE2 Receptors to Directly Infect Human Induced Pluripotent Stem Cell-Derived Kidney Podocytes. Kalejaiye TD, Bhattacharya R, Burt MA, Travieso T, Okafor AE, Mou X, Blasi M, Musah S. Front Cell Dev Biol. 2022 Apr 20;10:855340. doi: 10.3389/fcell.2022.855340. eCollection 2022. PubMed |
| Lymph node colonization induces tumor-immune tolerance to promote distant metastasis. Reticker-Flynn NE, Zhang W, Belk JA, Basto PA, Escalante NK, Pilarowski GOW, Bejnood A, Martins MM, Kenkel JA, Linde IL, Bagchi S, Yuan R, Chang S, Spitzer MH, Carmi Y, Cheng J, Tolentino LL, Choi O, Wu N, Kong CS, Gentles AJ, Sunwoo JB, Satpathy AT, Plevritis SK, Engleman EG. Cell. 2022 May 26;185(11):1924-1942.e23. doi: 10.1016/j.cell.2022.04.019. Epub 2022 May 6. PubMed |
| Comprehensive Target Screening and Cellular Profiling of the Cancer-Active Compound b-AP15 Indicate Abrogation of Protein Homeostasis and Organelle Dysfunction as the Primary Mechanism of Action. Gubat J, Selvaraju K, Sjostrand L, Kumar Singh D, Turkina MV, Schmierer B, Sabatier P, Zubarev RA, Linder S, D'Arcy P. Front Oncol. 2022 Apr 22;12:852980. doi: 10.3389/fonc.2022.852980. eCollection 2022. PubMed |
| Acquired chemoresistance drives spatial heterogeneity, chemoprotection and collective migration in pancreatic tumor spheroids. Thege FI, Cardle II, Gruber CN, Siemann MJ, Cong S, Wittmann K, Love J, Kirby BJ. PLoS One. 2022 May 26;17(5):e0267882. doi: 10.1371/journal.pone.0267882. eCollection 2022. PubMed |
| Loss of SP-A in the Lung Exacerbates Pulmonary Fibrosis. Kim K, Shin D, Lee G, Bae H. Int J Mol Sci. 2022 May 10;23(10). pii: ijms23105292. doi: 10.3390/ijms23105292. PubMed |
| SAFA facilitates chromatin opening of immune genes through interacting with anti-viral host RNAs. Cao L, Luo Y, Guo X, Liu S, Li S, Li J, Zhang Z, Zhao Y, Zhang Q, Gao F, Ji X, Gao X, Li Y, You F. PLoS Pathog. 2022 Jun 3;18(6):e1010599. doi: 10.1371/journal.ppat.1010599. eCollection 2022 Jun. PubMed |
| Proteomic and functional analyses of the periodic membrane skeleton in neurons. Zhou R, Han B, Nowak R, Lu Y, Heller E, Xia C, Chishti AH, Fowler VM, Zhuang X. Nat Commun. 2022 Jun 9;13(1):3196. doi: 10.1038/s41467-022-30720-x. PubMed |
| LILRB2-mediated TREM2 signaling inhibition suppresses microglia functions. Zhao P, Xu Y, Jiang LL, Fan X, Ku Z, Li L, Liu X, Deng M, Arase H, Zhu JJ, Huang TY, Zhao Y, Zhang C, Xu H, Tong Q, Zhang N, An Z. Mol Neurodegener. 2022 Jun 18;17(1):44. doi: 10.1186/s13024-022-00550-y. PubMed |
| KDM5A Inhibits Antitumor Immune Responses Through Downregulation of the Antigen-Presentation Pathway in Ovarian Cancer. Liu H, Lin J, Zhou W, Moses R, Dai Z, Kossenkov AV, Drapkin R, Bitler BG, Karakashev S, Zhang R. Cancer Immunol Res. 2022 Aug 3;10(8):1028-1038. doi: 10.1158/2326-6066.CIR-22-0088. PubMed |
| A New Functional Screening Platform Identifies Colistin Sulfate as an Enhancer of Natural Killer Cell Cytotoxicity. Cortes-Kaplan S, Kurdieh R, Hasim MS, Kaczmarek S, Taha Z, Maznyi G, McComb S, Lee SH, Diallo JS, Ardolino M. Cancers (Basel). 2022 Jun 8;14(12). pii: cancers14122832. doi: 10.3390/cancers14122832. PubMed |
| Epigenomic analysis reveals a dynamic and context-specific macrophage enhancer landscape associated with innate immune activation and tolerance. Zhang P, Amarasinghe HE, Whalley JP, Tay C, Fang H, Migliorini G, Brown AC, Allcock A, Scozzafava G, Rath P, Davies B, Knight JC. Genome Biol. 2022 Jun 24;23(1):136. doi: 10.1186/s13059-022-02702-1. PubMed |
| RUNDC3A regulates SNAP25-mediated chemotherapy resistance by binding AKT in gastric neuroendocrine carcinoma (GNEC). Chen P, Wang W, Wong SW, Li J, Wu Q, Zhang SD, Lin Y, Kwok HF. Cell Death Discov. 2022 Jun 25;8(1):296. doi: 10.1038/s41420-022-01084-4. PubMed |
| The small GTPase RAB10 regulates endosomal recycling of the LDL receptor and transferrin receptor in hepatocytes. Khan TG, Ginsburg D, Emmer BT. J Lipid Res. 2022 Aug;63(8):100248. doi: 10.1016/j.jlr.2022.100248. Epub 2022 Jun 24. PubMed |
| Regulatory Programs of B-cell Activation and Germinal Center Reaction Allow B-ALL Escape from CD19 CAR T-cell Therapy. Im NG, Guillaumet-Adkins A, Wal M, Rogers AJ, Frede J, Havig CC, Yang J, Anand P, Stegmann SK, Waldschmidt JM, Sotudeh N, Niu L, Voisine J, Schweiger MR, Grassberger C, Lohr JG, Knoechel B. Cancer Immunol Res. 2022 Sep 1;10(9):1055-1068. doi: 10.1158/2326-6066.CIR-21-0626. PubMed |
Optimal LentiCRISPR-Based System for Sequential CRISPR/Cas9 Screens.
Hutcheson RL, Hayes M, Sugden B.
ACS Synth Biol. 2022 Jun 29. doi: 10.1021/acssynbio.2c00152.
PubMed
Associated Plasmids |
| Polo-Like Kinase 1 Regulates Chromosomal Instability and Paclitaxel Resistance in Breast Cancer Cells. Quan M, Oh Y, Cho SY, Kim JH, Moon HG. J Breast Cancer. 2022 Jun;25(3):178-192. doi: 10.4048/jbc.2022.25.e28. PubMed |
Spatial regulation of AMPK signaling revealed by a sensitive kinase activity reporter.
Schmitt DL, Curtis SD, Lyons AC, Zhang JF, Chen M, He CY, Mehta S, Shaw RJ, Zhang J.
Nat Commun. 2022 Jul 5;13(1):3856. doi: 10.1038/s41467-022-31190-x.
PubMed
Associated Plasmids |
| Tumor suppressive functions of WNT5A in rhabdomyosarcoma. Ragab N, Bauer J, Uhmann A, Marx A, Hahn H, Simon-Keller K. Int J Oncol. 2022 Sep;61(3). pii: 102. doi: 10.3892/ijo.2022.5392. Epub 2022 Jul 7. PubMed |
| Integrated Stress Response Regulation of Corneal Epithelial Cell Motility and Cytokine Production. Chu HS, Peterson C, Chamling X, Berlinicke C, Zack D, Jun AS, Foster J. Invest Ophthalmol Vis Sci. 2022 Jul 8;63(8):1. doi: 10.1167/iovs.63.8.1. PubMed |
| Mast4 determines the cell fate of MSCs for bone and cartilage development. Kim P, Park J, Lee DJ, Mizuno S, Shinohara M, Hong CP, Jeong Y, Yun R, Park H, Park S, Yang KM, Lee MJ, Jang SP, Kim HY, Lee SJ, Song SU, Park KS, Tanaka M, Ohshima H, Cho JW, Sugiyama F, Takahashi S, Jung HS, Kim SJ. Nat Commun. 2022 Jul 8;13(1):3960. doi: 10.1038/s41467-022-31697-3. PubMed |
| Direct reprogramming of adult adipose-derived regenerative cells toward cardiomyocytes using six transcriptional factors. Narita S, Unno K, Kato K, Okuno Y, Sato Y, Tsumura Y, Fujikawa Y, Shimizu Y, Hayashida R, Kondo K, Shibata R, Murohara T. iScience. 2022 Jun 24;25(7):104651. doi: 10.1016/j.isci.2022.104651. eCollection 2022 Jul 15. PubMed |
| Progerin-Induced Impairment in Wound Healing and Proliferation in Vascular Endothelial Cells. Jiang Y, Ji JY. Front Aging. 2022 Mar 14;3:844885. doi: 10.3389/fragi.2022.844885. eCollection 2022. PubMed |
| Structural basis for acyl chain control over glycosphingolipid sorting and vesicular trafficking. Schmieder SS, Tatituri R, Anderson M, Kelly K, Lencer WI. Cell Rep. 2022 Jul 12;40(2):111063. doi: 10.1016/j.celrep.2022.111063. PubMed |
| Decline of humoral immune responses after natural SARS-CoV-2 infection can be efficiently reversed by vaccination. Oktelik FB, Yilmaz V, Gelmez MY, Akdeniz N, Pamukcu C, Sutlu T, Kose M, Tuzun E, Deniz G. Can J Microbiol. 2022 Aug 1;68(8):543-550. doi: 10.1139/cjm-2022-0003. Epub 2022 Jul 19. PubMed |
| Nicotinamide riboside alleviates cisplatin-induced peripheral neuropathy via SIRT2 activation. Acklin S, Sadhukhan R, Du W, Patra M, Cholia R, Xia F. Neurooncol Adv. 2022 Jun 27;4(1):vdac101. doi: 10.1093/noajnl/vdac101. eCollection 2022 Jan-Dec. PubMed |
| Human papillomaviruses sensitize cells to DNA damage induced apoptosis by targeting the innate immune sensor cGAS. Gusho E, Laimins LA. PLoS Pathog. 2022 Jul 25;18(7):e1010725. doi: 10.1371/journal.ppat.1010725. eCollection 2022 Jul. PubMed |
| Inhibition of LSD1 with Bomedemstat Sensitizes Small Cell Lung Cancer to Immune Checkpoint Blockade and T-Cell Killing. Hiatt JB, Sandborg H, Garrison SM, Arnold HU, Liao SY, Norton JP, Friesen TJ, Wu F, Sutherland KD, Rienhoff HY, Martins R, Houghton AM, Srivastava S, MacPherson D. Clin Cancer Res. 2022 Oct 14;28(20):4551-4564. doi: 10.1158/1078-0432.CCR-22-1128. PubMed |
| Phenotypic heterogeneity driven by plasticity of the intermediate EMT state governs disease progression and metastasis in breast cancer. Brown MS, Abdollahi B, Wilkins OM, Lu H, Chakraborty P, Ognjenovic NB, Muller KE, Jolly MK, Christensen BC, Hassanpour S, Pattabiraman DR. Sci Adv. 2022 Aug 5;8(31):eabj8002. doi: 10.1126/sciadv.abj8002. Epub 2022 Aug 3. PubMed |
| Discovery and engineering of an anti-TREM2 antibody to promote amyloid plaque clearance by microglia in 5XFAD mice. Zhao P, Xu Y, Fan X, Li L, Li X, Arase H, Tong Q, Zhang N, An Z. MAbs. 2022 Jan-Dec;14(1):2107971. doi: 10.1080/19420862.2022.2107971. PubMed |
| Dolutegravir Inhibits Proliferation and Motility of BT-20 Tumor Cells Through Inhibition of Human Endogenous Retrovirus Type K. Li J, Lin J, Lin JR, Farris M, Robbins L, Andrada L, Grohol B, Nong S, Liu Y. Cureus. 2022 Jul 3;14(7):e26525. doi: 10.7759/cureus.26525. eCollection 2022 Jul. PubMed |
| Direct control of lysosomal catabolic activity by mTORC1 through regulation of V-ATPase assembly. Ratto E, Chowdhury SR, Siefert NS, Schneider M, Wittmann M, Helm D, Palm W. Nat Commun. 2022 Aug 17;13(1):4848. doi: 10.1038/s41467-022-32515-6. PubMed |
| Chromatin-bound RB targets promoters, enhancers, and CTCF-bound loci and is redistributed by cell-cycle progression. Sanidas I, Lee H, Rumde PH, Boulay G, Morris R, Golczer G, Stanzione M, Hajizadeh S, Zhong J, Ryan MB, Corcoran RB, Drapkin BJ, Rivera MN, Dyson NJ, Lawrence MS. Mol Cell. 2022 Sep 15;82(18):3333-3349.e9. doi: 10.1016/j.molcel.2022.07.014. Epub 2022 Aug 17. PubMed |
| Defining the HIV Capsid Binding Site of Nucleoporin 153. Li S, Patel JS, Yang J, Crabtree AM, Rubenstein BM, Lund-Andersen PK, Ytreberg FM, Rowley PA. mSphere. 2022 Oct 26;7(5):e0031022. doi: 10.1128/msphere.00310-22. Epub 2022 Aug 30. PubMed |
| RBM45 is an m(6)A-binding protein that affects neuronal differentiation and the splicing of a subset of mRNAs. Choi SH, Flamand MN, Liu B, Zhu H, Hu M, Wang M, Sewell J, Holley CL, Al-Hashimi HM, Meyer KD. Cell Rep. 2022 Aug 30;40(9):111293. doi: 10.1016/j.celrep.2022.111293. PubMed |
| Accounting for small variations in the tracrRNA sequence improves sgRNA activity predictions for CRISPR screening. DeWeirdt PC, McGee AV, Zheng F, Nwolah I, Hegde M, Doench JG. Nat Commun. 2022 Sep 6;13(1):5255. doi: 10.1038/s41467-022-33024-2. PubMed |
| SHP2 regulates adipose maintenance and adipocyte-pancreatic cancer cell crosstalk via PDHA1. Olou AA, Ambrose J, Jack JL, Walsh M, Ruckert MT, Eades AE, Bye BA, Dandawate P, VanSaun MN. J Cell Commun Signal. 2022 Sep 8. doi: 10.1007/s12079-022-00691-1. PubMed |
| TRIM28 Is a Novel Regulator of CD133 Expression Associated with Cancer Stem Cell Phenotype. Kim YS, Potashnikova DM, Gisina AM, Kholodenko IV, Kopylov AT, Tikhonova OV, Kurbatov LK, Saidova AA, Tvorogova AV, Kholodenko RV, Belousov PV, Vorobjev IA, Zgoda VG, Yarygin KN, Lupatov AY. Int J Mol Sci. 2022 Aug 30;23(17):9874. doi: 10.3390/ijms23179874. PubMed |
| Development and Characterization of a Luciferase Labeled, Syngeneic Murine Model of Ovarian Cancer. Russell S, Lim F, Peters PN, Wardell SE, Whitaker R, Chang CY, Previs RA, McDonnell DP. Cancers (Basel). 2022 Aug 30;14(17):4219. doi: 10.3390/cancers14174219. PubMed |
| Inhibition of O-GlcNAcase Inhibits Hematopoietic and Leukemic Stem Cell Self-Renewal and Drives Dendritic Cell Differentiation via STAT3/5 Signaling. Luanpitpong S, Rodboon N, Samart P, Janan M, Klaihmon P, Lorthongpanich C, U-Pratya Y, Issaragrisil S. Stem Cells. 2022 Dec 31;40(12):1078-1093. doi: 10.1093/stmcls/sxac068. PubMed |
| UBE2T promotes glioblastoma malignancy through ubiquitination-mediated degradation of RPL6. Tao X, Wu X, Zhou P, Yu X, Zhao C, Peng X, Zhang K, Shen L, Peng J, Yang L. Cancer Sci. 2023 Feb;114(2):521-532. doi: 10.1111/cas.15604. Epub 2022 Oct 14. PubMed |
| A novel oncogenic enhancer of estrogen receptor-positive breast cancer. Bao C, Duan J, Xie Y, Liu Y, Li P, Li J, Zhao H, Guo H, Men Y, Ren Y, Xu J, Wang G, Lu W. Mol Ther Nucleic Acids. 2022 Aug 24;29:836-851. doi: 10.1016/j.omtn.2022.08.029. eCollection 2022 Sep 13. PubMed |
| Multiple centrosomes enhance migration and immune cell effector functions of mature dendritic cells. Weier AK, Homrich M, Ebbinghaus S, Juda P, Mikova E, Hauschild R, Zhang L, Quast T, Mass E, Schlitzer A, Kolanus W, Burgdorf S, Gruss OJ, Hons M, Wieser S, Kiermaier E. J Cell Biol. 2022 Dec 5;221(12):e202107134. doi: 10.1083/jcb.202107134. Epub 2022 Oct 10. PubMed |
| Thermal-exchange HLA-E multimers reveal specificity in HLA-E and NKG2A/CD94 complex interactions. Ruibal P, Derksen I, van Wolfswinkel M, Voogd L, Franken KLMC, El Hebieshy AF, van Hall T, Schoufour TAW, Wijdeven RH, Ottenhoff THM, Scheeren FA, Joosten SA. Immunology. 2023 Mar;168(3):526-537. doi: 10.1111/imm.13591. Epub 2022 Oct 20. PubMed |
| A dominant negative mitofusin causes mitochondrial perinuclear clusters because of aberrant tethering. Sloat SR, Hoppins S. Life Sci Alliance. 2022 Oct 13;6(1):e202101305. doi: 10.26508/lsa.202101305. Print 2023 Jan. PubMed |
| NSP4 and ORF9b of SARS-CoV-2 Induce Pro-Inflammatory Mitochondrial DNA Release in Inner Membrane-Derived Vesicles. Faizan MI, Chaudhuri R, Sagar S, Albogami S, Chaudhary N, Azmi I, Akhtar A, Ali SM, Kumar R, Iqbal J, Joshi MC, Kharya G, Seth P, Roy SS, Ahmad T. Cells. 2022 Sep 23;11(19):2969. doi: 10.3390/cells11192969. PubMed |
| Therapy free of cells vs human mesenchymal stem cells from umbilical cord stroma to treat the inflammation in OA. Morente-Lopez M, Mato-Basalo R, Lucio-Gallego S, Silva-Fernandez L, Gonzalez-Rodriguez A, De Toro FJ, Fafian-Labora JA, Arufe MC. Cell Mol Life Sci. 2022 Oct 20;79(11):557. doi: 10.1007/s00018-022-04580-z. PubMed |
| Increased CaMKK2 Expression Is an Adaptive Response That Maintains the Fitness of Tumor-Infiltrating Natural Killer Cells. Juras PK, Racioppi L, Mukherjee D, Artham S, Gao X, Akullian D'Agostino L, Chang CY, McDonnell DP. Cancer Immunol Res. 2023 Jan 3;11(1):109-122. doi: 10.1158/2326-6066.CIR-22-0391. PubMed |
| TRIM59 guards ER proteostasis and prevents Bortezomib-mediated colorectal cancer (CRC) cells' killing. Feng X, Yang G, Zhang L, Tao S, Shim JS, Chen L, Wu Q. Invest New Drugs. 2022 Dec;40(6):1244-1253. doi: 10.1007/s10637-022-01306-7. Epub 2022 Oct 28. PubMed |
| Frataxin deficiency alters gene expression in Friedreich ataxia derived IPSC-neurons and cardiomyocytes. Angulo MB, Bertalovitz A, Argenziano MA, Yang J, Patel A, Zesiewicz T, McDonald TV. Mol Genet Genomic Med. 2023 Jan;11(1):e2093. doi: 10.1002/mgg3.2093. Epub 2022 Nov 11. PubMed |
| An mTORC1 to HRI signaling axis promotes cytotoxicity of proteasome inhibitors in multiple myeloma. Darawshi O, Muz B, Naamat SG, Praveen B, Mahameed M, Goldberg K, Dipta P, Shmuel M, Forno F, Boukeileh S, Pahima H, Hermann J, Raab MS, Poos AM, Weinhold N, Rosenbluh C, Gatt ME, Palm W, Azab AK, Tirosh B. Cell Death Dis. 2022 Nov 18;13(11):969. doi: 10.1038/s41419-022-05421-4. PubMed |
| The leucine-rich repeat (LRR) domain of NLRP3 is required for NLRP3 inflammasome activation in macrophages. Duan Y, Wang J, Cai J, Kelley N, He Y. J Biol Chem. 2022 Dec;298(12):102717. doi: 10.1016/j.jbc.2022.102717. Epub 2022 Nov 17. PubMed |
| Combating Drug Resistance by Exploiting miRNA-200c-Controlled Phase II Detoxification. Kohler B, Dubovik S, Horterer E, Wilk U, Stockl JB, Tekarslan-Sahin H, Ljepoja B, Paulitschke P, Frohlich T, Wagner E, Roidl A. Cancers (Basel). 2022 Nov 11;14(22):5554. doi: 10.3390/cancers14225554. PubMed |
| Bcl-2 Family Members Bcl-xL and Bax Cooperatively Contribute to Bortezomib Resistance in Mantle Cell Lymphoma. Luanpitpong S, Janan M, Yosudjai J, Poohadsuan J, Chanvorachote P, Issaragrisil S. Int J Mol Sci. 2022 Nov 21;23(22):14474. doi: 10.3390/ijms232214474. PubMed |
| Autophagy inhibition signals through senescence to promote tumor suppression. Peng N, Kang HH, Feng Y, Minikes AM, Jiang X. Autophagy. 2022 Dec 15:1-17. doi: 10.1080/15548627.2022.2155794. PubMed |
| Arginine-rich C9ORF72 ALS proteins stall ribosomes in a manner distinct from a canonical ribosome-associated quality control substrate. Kriachkov V, Ormsby AR, Kusnadi EP, McWilliam HEG, Mintern JD, Amarasinghe SL, Ritchie ME, Furic L, Hatters DM. J Biol Chem. 2023 Jan;299(1):102774. doi: 10.1016/j.jbc.2022.102774. Epub 2022 Dec 5. PubMed |
| Engineering inducible biomolecular assemblies for genome imaging and manipulation in living cells. Peng Q, Huang Z, Sun K, Liu Y, Yoon CW, Harrison RES, Schmitt DL, Zhu L, Wu Y, Tasan I, Zhao H, Zhang J, Zhong S, Chien S, Wang Y. Nat Commun. 2022 Dec 24;13(1):7933. doi: 10.1038/s41467-022-35504-x. PubMed |
| Generation of Induced Pluripotent Stem Cells from Lymphoblastoid Cell Lines by Electroporation of Episomal Vectors. Kim M, Park J, Kim S, Han DW, Shin B, Scholer HR, Kim J, Kim KP. Int J Stem Cells. 2023 Feb 28;16(1):36-43. doi: 10.15283/ijsc22177. Epub 2022 Dec 31. PubMed |
| Gene regulatory network reconfiguration in direct lineage reprogramming. Kamimoto K, Adil MT, Jindal K, Hoffmann CM, Kong W, Yang X, Morris SA. Stem Cell Reports. 2023 Jan 10;18(1):97-112. doi: 10.1016/j.stemcr.2022.11.010. Epub 2022 Dec 29. PubMed |
| PAX8 modulates the tumor microenvironment of high grade serous ovarian cancer through changes in the secretome. Salvi A, Hardy LR, Heath KN, Watry S, Pergande MR, Cologna SM, Burdette JE. Neoplasia. 2023 Feb;36:100866. doi: 10.1016/j.neo.2022.100866. Epub 2022 Dec 29. PubMed |
| A delicate balance between antibody evasion and ACE2 affinity for Omicron BA.2.75. Huo J, Dijokaite-Guraliuc A, Liu C, Zhou D, Ginn HM, Das R, Supasa P, Selvaraj M, Nutalai R, Tuekprakhon A, Duyvesteyn HME, Mentzer AJ, Skelly D, Ritter TG, Amini A, Bibi S, Adele S, Johnson SA, Paterson NG, Williams MA, Hall DR, Plowright M, Newman TAH, Hornsby H, de Silva TI, Temperton N, Klenerman P, Barnes E, Dunachie SJ, Pollard AJ, Lambe T, Goulder P, Fry EE, Mongkolsapaya J, Ren J, Stuart DI, Screaton GR. Cell Rep. 2023 Jan 31;42(1):111903. doi: 10.1016/j.celrep.2022.111903. Epub 2022 Dec 14. PubMed |
| Behavioral context improves optogenetic stimulation of transplanted dopaminergic cells in unilateral 6-OHDA rats. Anderson KA, Whitehead BJ, Petersen ED, Kemme MR, Wedster A, Hochgeschwender U, Sandstrom MI. Behav Brain Res. 2023 Mar 12;441:114279. doi: 10.1016/j.bbr.2022.114279. Epub 2022 Dec 29. PubMed |
| Characterization of Sialic Acid-Independent Simian Rotavirus Mutants in Viral Infection and Pathogenesis. Yamasaki M, Kanai Y, Wakamura Y, Kotaki T, Minami S, Nouda R, Nurdin JA, Kobayashi T. J Virol. 2023 Jan 31;97(1):e0139722. doi: 10.1128/jvi.01397-22. Epub 2023 Jan 5. PubMed |
CDT1 inhibits CMG helicase in early S phase to separate origin licensing from DNA synthesis.
Ratnayeke N, Baris Y, Chung M, Yeeles JTP, Meyer T.
Mol Cell. 2023 Jan 5;83(1):26-42.e13. doi: 10.1016/j.molcel.2022.12.004.
PubMed
Associated Plasmids |
| Repeat-associated non-AUG translation induces cytoplasmic aggregation of CAG repeat-containing RNAs. Das MR, Chang Y, Anderson R, Saunders RA, Zhang N, Tomberlin CP, Vale RD, Jain A. Proc Natl Acad Sci U S A. 2023 Jan 17;120(3):e2215071120. doi: 10.1073/pnas.2215071120. Epub 2023 Jan 9. PubMed |
| Ectopic CH60 mediates HAPLN1-induced cell survival signaling in multiple myeloma. De Bakshi D, Chen YC, Wuerzberger-Davis SM, Ma M, Waters BJ, Li L, Suzuki A, Miyamoto S. Life Sci Alliance. 2022 Dec 13;6(3):e202201636. doi: 10.26508/lsa.202201636. Print 2023 Mar. PubMed |
| Annexin A1 is a polarity cue that directs mitotic spindle orientation during mammalian epithelial morphogenesis. Fankhaenel M, Hashemi FSG, Mourao L, Lucas E, Hosawi MM, Skipp P, Morin X, Scheele CLGJ, Elias S. Nat Commun. 2023 Jan 11;14(1):151. doi: 10.1038/s41467-023-35881-x. PubMed |
| Trophoblast-specific knockdown of CSPG4 expression causes pregnancy complications with poor placentation in mice. Xu J, Yuan A, Su R, Yang Q, Fan X, Zhang J. Reprod Biol. 2023 Mar;23(1):100731. doi: 10.1016/j.repbio.2023.100731. Epub 2023 Jan 10. PubMed |
| A conditional Smg6 mutant mouse model reveals circadian clock regulation through the nonsense-mediated mRNA decay pathway. Katsioudi G, Dreos R, Arpa ES, Gaspari S, Liechti A, Sato M, Gabriel CH, Kramer A, Brown SA, Gatfield D. Sci Adv. 2023 Jan 13;9(2):eade2828. doi: 10.1126/sciadv.ade2828. Epub 2023 Jan 13. PubMed |
| Cytochalasin B-Induced Membrane Vesicles from TRAIL-Overexpressing Mesenchymal Stem Cells Induce Extrinsic Pathway of Apoptosis in Breast Cancer Mouse Model. Chulpanova DS, Pukhalskaia TV, Gilazieva ZE, Filina YV, Mansurova MN, Rizvanov AA, Solovyeva VV. Curr Issues Mol Biol. 2023 Jan 9;45(1):571-592. doi: 10.3390/cimb45010038. PubMed |
| Enhancing adoptive T-cell therapy with fucoidan-based IL-2 delivery microcapsules. Jeon EY, Choi DS, Choi S, Won JY, Jo Y, Kim HB, Jung Y, Shin SC, Min H, Choi HW, Lee MS, Park Y, Chung JJ, Jin HS. Bioeng Transl Med. 2022 Jul 5;8(1):e10362. doi: 10.1002/btm2.10362. eCollection 2023 Jan. PubMed |
| The selective autophagy adaptor p62/SQSTM1 forms phase condensates regulated by HSP27 that facilitate the clearance of damaged lysosomes via lysophagy. Gallagher ER, Holzbaur ELF. Cell Rep. 2023 Feb 28;42(2):112037. doi: 10.1016/j.celrep.2023.112037. Epub 2023 Jan 25. PubMed |
| Chromatin complex dependencies reveal targeting opportunities in leukemia. Najm FJ, DeWeirdt P, Moore MM, Bevill SM, El Farran CA, Macias KA, Hegde M, Waterbury AL, Liau BB, van Galen P, Doench JG, Bernstein BE. Nat Commun. 2023 Jan 27;14(1):448. doi: 10.1038/s41467-023-36150-7. PubMed |
| Regulation of beige adipocyte thermogenesis by the cold-repressed ER protein NNAT. Choi KM, Ko CY, An SM, Cho SH, Rowland DJ, Kim JH, Fasoli A, Chaudhari AJ, Bers DM, Yoon JC. Mol Metab. 2023 Mar;69:101679. doi: 10.1016/j.molmet.2023.101679. Epub 2023 Jan 25. PubMed |
| A hierarchical pathway for assembly of the distal appendages that organize primary cilia. Kanie T, Love JF, Fisher SD, Gustavsson AK, Jackson PK. bioRxiv [Preprint]. 2023 Jan 10:2023.01.06.522944. doi: 10.1101/2023.01.06.522944. PubMed |
A dual sgRNA library design to probe genetic modifiers using genome-wide CRISPRi screens.
Guna A, Page KR, Replogle JR, Esantsi TK, Wang ML, Weissman JS, Voorhees RM.
bioRxiv. 2023 Jan 22:2023.01.22.525086. doi: 10.1101/2023.01.22.525086. Preprint.
PubMed
Associated Plasmids |
| Myristoylated Neuronal Calcium Sensor-1 captures the ciliary vesicle at distal appendages. Kanie T, Ng R, Abbott KL, Pongs O, Jackson PK. bioRxiv. 2023 Jan 10:2023.01.06.523037. doi: 10.1101/2023.01.06.523037. Preprint. PubMed |
| Single-chromosome dynamics reveals locus-dependent dynamics and chromosome territory orientation. Chung YC, Bisht M, Thuma J, Tu LC. J Cell Sci. 2023 Feb 15;136(4):jcs260137. doi: 10.1242/jcs.260137. Epub 2023 Feb 27. PubMed |
| Combining single-cell transcriptomics and CellTagging to identify differentiation trajectories of human adipose-derived mesenchymal stem cells. Lin K, Yang Y, Cao Y, Liang J, Qian J, Wang X, Han Q. Stem Cell Res Ther. 2023 Feb 1;14(1):14. doi: 10.1186/s13287-023-03237-3. PubMed |
| Cell cycle-dependent palmitoylation of protocadherin 7 by ZDHHC5 promotes successful cytokinesis. Ozkan NE, Yigit BN, Degirmenci BS, Qureshi MH, Yapici GN, Kamacioglu A, Bavili N, Kiraz A, Ozlu N. J Cell Sci. 2023 Mar 15;136(6):jcs260266. doi: 10.1242/jcs.260266. Epub 2023 Mar 20. PubMed |
| Tet-Regulated Expression and Optical Clearing for In Vivo Visualization of Genetically Encoded Chimeric dCas9/Fluorescent Protein Probes. Maloshenok L, Abushinova G, Kazachkina N, Bogdanov A Jr, Zherdeva V. Materials (Basel). 2023 Jan 19;16(3):940. doi: 10.3390/ma16030940. PubMed |
| A dual-activity topoisomerase complex promotes both transcriptional activation and repression in response to starvation. Su S, Xue Y, Lee SK, Zhang Y, Fan J, De S, Sharov A, Wang W. Nucleic Acids Res. 2023 Mar 21;51(5):2415-2433. doi: 10.1093/nar/gkad086. PubMed |
| BAG3 regulates the specificity of the recognition of specific MAPT species by NBR1 and SQSTM1. Lin H, Sandkuhler S, Dunlea C, King DH, Johnson GVW. bioRxiv. 2023 Feb 9:2023.02.08.527546. doi: 10.1101/2023.02.08.527546. Preprint. PubMed |
| CRACD loss promotes small cell lung cancer tumorigenesis via EZH2-mediated immune evasion. Zhang S, Kim KB, Huang Y, Kim DW, Kim B, Ko KP, Zou G, Zhang J, Jun S, Kirk NA, Hwang YE, Ban YH, Chan JM, Rudin CM, Park KS, Park JI. bioRxiv [Preprint]. 2023 May 17:2023.02.15.528365. doi: 10.1101/2023.02.15.528365. PubMed |
| Evaluation of CAR-T Cells' Cytotoxicity against Modified Solid Tumor Cell Lines. Valiullina AK, Zmievskaya EA, Ganeeva IA, Zhuravleva MN, Garanina EE, Rizvanov AA, Petukhov AV, Bulatov ER. Biomedicines. 2023 Feb 19;11(2):626. doi: 10.3390/biomedicines11020626. PubMed |
| CAMKK2 is upregulated in primary human osteoarthritis and its inhibition protects against chondrocyte apoptosis. Dilley JE, Seetharam A, Ding X, Bello MA, Shutter J, Burr DB, Natoli RM, McKinley TO, Sankar U. Osteoarthritis Cartilage. 2023 Jul;31(7):908-918. doi: 10.1016/j.joca.2023.02.072. Epub 2023 Feb 27. PubMed |
| Candida albicans stimulates the formation of a multi-receptor complex that mediates epithelial cell invasion during oropharyngeal infection. Phan QT, Solis NV, Cravener MV, Swidergall M, Lin J, Huang MY, Liu H, Singh S, Ibrahim AS, Mazzone M, Mitchell AP, Filler SG. bioRxiv. 2023 Feb 23:2023.02.23.529756. doi: 10.1101/2023.02.23.529756. Preprint. PubMed |
| Synthetic enforcement of STING signaling in cancer cells appropriates the immune microenvironment for checkpoint inhibitor therapy. Vornholz L, Isay SE, Kurgyis Z, Strobl DC, Loll P, Mosa MH, Luecken MD, Sterr M, Lickert H, Winter C, Greten FR, Farin HF, Theis FJ, Ruland J. Sci Adv. 2023 Mar 17;9(11):eadd8564. doi: 10.1126/sciadv.add8564. Epub 2023 Mar 15. PubMed |
| Activation of Hippo Pathway Damages Slit Diaphragm by Deprivation of Ajuba Proteins. Gilhaus K, Cepok C, Kamm D, Surmann B, Nedvetsky PI, Emich J, Sundukova A, Saatkamp K, Nusse H, Klingauf J, Wennmann DO, George B, Krahn MP, Pavenstadt HJ, Vollenbroker BA. J Am Soc Nephrol. 2023 Jun 1;34(6):1039-1055. doi: 10.1681/ASN.0000000000000107. Epub 2023 Mar 16. PubMed |
| GEMC1 and MCIDAS interactions with SWI/SNF complexes regulate the multiciliated cell-specific transcriptional program. Lewis M, Terre B, Knobel PA, Cheng T, Lu H, Attolini CS, Smak J, Coyaud E, Garcia-Cao I, Sharma S, Vineethakumari C, Querol J, Gil-Gomez G, Piergiovanni G, Costanzo V, Peiro S, Raught B, Zhao H, Salvatella X, Roy S, Mahjoub MR, Stracker TH. Cell Death Dis. 2023 Mar 17;14(3):201. doi: 10.1038/s41419-023-05720-4. PubMed |
| DNMT3A low-expression is correlated to poor prognosis in childhood B-ALL and confers resistance to daunorubicin on leukemic cells. Li W, Liu S, Wang C, Cui L, Zhao X, Liu W, Zhang R, Li Z. BMC Cancer. 2023 Mar 18;23(1):255. doi: 10.1186/s12885-023-10724-6. PubMed |
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| Genome-Scale Analysis of Cellular Restriction Factors That Inhibit Transgene Expression from Adeno-Associated Virus Vectors. Ngo AM, Puschnik AS. J Virol. 2023 Apr 27;97(4):e0194822. doi: 10.1128/jvi.01948-22. Epub 2023 Mar 27. PubMed |
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An adenine base editor variant expands context compatibility.
Xiao YL, Wu Y, Tang W.
Nat Biotechnol. 2024 Jan 2. doi: 10.1038/s41587-023-01994-3.
PubMed
Associated Plasmids |
| Mitofusin 1 silencing decreases the senescent associated secretory phenotype, promotes immune cell recruitment and delays melanoma tumor growth after chemotherapy. Tarallo D, Martinez J, Leyva A, Monaco A, Perroni C, Tassano M, Gambini JP, Cappetta M, Duran R, Moreno M, Quijano C. Sci Rep. 2024 Jan 9;14(1):909. doi: 10.1038/s41598-024-51427-7. PubMed |
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