pSpCas9(BB)-2A-Puro (PX459) V2.0 Citations (1102)

Originally described in: Genome engineering using the CRISPR-Cas9 system.
Ran FA, Hsu PD, Wright J, Agarwala V, Scott DA, Zhang F Nat Protoc. 2013 Nov;8(11):2281-308. doi: 10.1038/nprot.2013.143. Epub 2013 Oct 24. PubMed Journal

Articles Citing pSpCas9(BB)-2A-Puro (PX459) V2.0

Articles
A complex of ZO-1 and the BAR Domain Protein TOCA-1 Regulates Actin Assembly at the Tight Junction. Van Itallie CM, Tietgens AJ, Krystofiak E, Kachar B, Anderson JM. Mol Biol Cell. 2015 Jun 10. pii: mbc.E15-04-0232. PubMed
Generation of a conditional analog-sensitive kinase in human cells using CRISPR/Cas9-mediated genome engineering. Moyer TC, Holland AJ. Methods Cell Biol. 2015;129:19-36. doi: 10.1016/bs.mcb.2015.03.017. Epub 2015 May 27. PubMed
Mechanisms of Enhancer-mediated Hormonal Control of Vitamin D Receptor Gene Expression in Target Cells. Lee SM, Meyer MB, Benkusky NA, O'Brien CA, Pike JW. J Biol Chem. 2015 Dec 18;290(51):30573-86. doi: 10.1074/jbc.M115.693614. Epub 2015 Oct 25. PubMed
Improved methods of AAV-mediated gene targeting for human cell lines using ribosome-skipping 2A peptide. Karnan S, Ota A, Konishi Y, Wahiduzzaman M, Hosokawa Y, Konishi H. Nucleic Acids Res. 2015 Dec 10. pii: gkv1338. PubMed Associated Plasmids pAAV-2Aneo pAAV-2Aneo v2
PAFAH1B1 and the lncRNA NONHSAT073641 maintain an angiogenic phenotype in human endothelial cells. Josipovic I, Fork C, Preussner J, Prior KK, Iloska D, Vasconez AE, Labocha S, Angioni C, Thomas D, Ferreiros N, Looso M, Pullamsetti SS, Geisslinger G, Steinhilber D, Brandes RP, Leisegang MS. Acta Physiol (Oxf). 2016 Apr 28. doi: 10.1111/apha.12700. PubMed Associated Plasmids pcDNA3.1+-PAFAH1B1 pcDNA3.1+-PAFAH1B1_R22- pcDNA3.1+-NONHSAT073641 pSpCas9(BB)-2A-Puro-Exon4-PAFAH1B1 pSpCas9(BB)-2A-Intron4-PAFAH1B1
Manipulating the Prion Protein Gene Sequence and Expression Levels with CRISPR/Cas9. Kaczmarczyk L, Mende Y, Zevnik B, Jackson WS. PLoS One. 2016 Apr 29;11(4):e0154604. doi: 10.1371/journal.pone.0154604. eCollection 2016. PubMed Associated Plasmids pX330_HR_Prnp_3 pX335_HR_Prnp_3 pX459_HR_Prnp_3 sgRNA(MS2)_Prnp_SAM1 sgRNA(MS2)_Prnp_SAM2
Tumour resistance in induced pluripotent stem cells derived from naked mole-rats. Miyawaki S, Kawamura Y, Oiwa Y, Shimizu A, Hachiya T, Bono H, Koya I, Okada Y, Kimura T, Tsuchiya Y, Suzuki S, Onishi N, Kuzumaki N, Matsuzaki Y, Narita M, Ikeda E, Okanoya K, Seino K, Saya H, Okano H, Miura K. Nat Commun. 2016 May 10;7:11471. doi: 10.1038/ncomms11471. PubMed
Glutathione adducts induced by ischemia and deletion of glutaredoxin-1 stabilize HIF-1alpha and improve limb revascularization. Watanabe Y, Murdoch CE, Sano S, Ido Y, Bachschmid MM, Cohen RA, Matsui R. Proc Natl Acad Sci U S A. 2016 May 24;113(21):6011-6. doi: 10.1073/pnas.1524198113. Epub 2016 May 9. PubMed
Golden Gate Assembly of CRISPR gRNA expression array for simultaneously targeting multiple genes. Vad-Nielsen J, Lin L, Bolund L, Nielsen AL, Luo Y. Cell Mol Life Sci. 2016 May 13. PubMed Associated Plasmids pMA-SpCas9-g1 pMA-SpCas9-g2 pMA-SpCas9-g3 pMA-SpCas9-g4 pMA-SpCas9-g5 More ...
Genome engineering in ophthalmology: Application of CRISPR/Cas to the treatment of eye disease. Hung SS, McCaughey T, Swann O, Pebay A, Hewitt AW. Prog Retin Eye Res. 2016 Jul;53:1-20. doi: 10.1016/j.preteyeres.2016.05.001. Epub 2016 May 13. PubMed
The BRPF2/BRD1-MOZ complex is involved in retinoic acid-induced differentiation of embryonic stem cells. Cho HI, Kim MS, Jang YK. Exp Cell Res. 2016 May 30. pii: S0014-4827(16)30140-9. doi: 10.1016/j.yexcr.2016.05.022. PubMed
Cell surface protease activation during RAS transformation: Critical role of the plasminogen receptor, S100A10. Madureira PA, Bharadwaj AG, Bydoun M, Garant K, O'Connell P, Lee P, Waisman DM. Oncotarget. 2016 Jul 26;7(30):47720-47737. doi: 10.18632/oncotarget.10279. PubMed
The Influenza A Virus Genotype Determines the Antiviral Function of NF-kappaB. Dam S, Kracht M, Pleschka S, Schmitz ML. J Virol. 2016 Aug 12;90(17):7980-90. doi: 10.1128/JVI.00946-16. Print 2016 Sep 1. PubMed
AAV-Mediated CRISPR/Cas Gene Editing of Retinal Cells In Vivo. Hung SS, Chrysostomou V, Li F, Lim JK, Wang JH, Powell JE, Tu L, Daniszewski M, Lo C, Wong RC, Crowston JG, Pebay A, King AE, Bui BV, Liu GS, Hewitt AW. Invest Ophthalmol Vis Sci. 2016 Jun 1;57(7):3470-6. doi: 10.1167/iovs.16-19316. PubMed Associated Plasmids AAV-U6-sgRNA-hSyn-mCherry
A CRISPR screen defines a signal peptide processing pathway required by flaviviruses. Zhang R, Miner JJ, Gorman MJ, Rausch K, Ramage H, White JP, Zuiani A, Zhang P, Fernandez E, Zhang Q, Dowd KA, Pierson TC, Cherry S, Diamond MS. Nature. 2016 Jul 7;535(7610):164-8. doi: 10.1038/nature18625. Epub 2016 Jun 17. PubMed
TREM2 deficiency reduces the efficacy of immunotherapeutic amyloid clearance. Xiang X, Werner G, Bohrmann B, Liesz A, Mazaheri F, Capell A, Feederle R, Knuesel I, Kleinberger G, Haass C. EMBO Mol Med. 2016 Sep 1;8(9):992-1004. doi: 10.15252/emmm.201606370. PubMed
An Evolutionary Conserved Epigenetic Mark of Polycomb Response Elements Implemented by Trx/MLL/COMPASS. Rickels R, Hu D, Collings CK, Woodfin AR, Piunti A, Mohan M, Herz HM, Kvon E, Shilatifard A. Mol Cell. 2016 Jul 21;63(2):318-328. doi: 10.1016/j.molcel.2016.06.018. PubMed
Generation of Targeted Genomic Deletions Through CRISPR/Cas System in Zebrafish. Xiao A, Zhang B. Methods Mol Biol. 2016;1451:65-79. doi: 10.1007/978-1-4939-3771-4_5. PubMed
CRISPR/Cas9-Mediated Trp53 and Brca2 Knockout to Generate Improved Murine Models of Ovarian High-Grade Serous Carcinoma. Walton J, Blagih J, Ennis D, Leung E, Dowson S, Farquharson M, Tookman LA, Orange C, Athineos D, Mason S, Stevenson D, Blyth K, Strathdee D, Balkwill FR, Vousden K, Lockley M, McNeish IA. Cancer Res. 2016 Oct 15;76(20):6118-6129. Epub 2016 Aug 16. PubMed
Comprehensive Protocols for CRISPR/Cas9-based Gene Editing in Human Pluripotent Stem Cells. Santos DP, Kiskinis E, Eggan K, Merkle FT. Curr Protoc Stem Cell Biol. 2016 Aug 17;38:5B.6.1-5B.6.60. doi: 10.1002/cpsc.15. PubMed
Generation of a human induced pluripotent stem cell line via CRISPR-Cas9 mediated integration of a site-specific heterozygous mutation in CHMP2B. Zhang Y, Schmid B, Nielsen TT, Nielsen JE, Clausen C, Hyttel P, Holst B, Freude KK. Stem Cell Res. 2016 Jun 16;17(1):148-150. doi: 10.1016/j.scr.2016.06.004. PubMed
Generation of a human induced pluripotent stem cell line via CRISPR-Cas9 mediated integration of a site-specific homozygous mutation in CHMP2B. Zhang Y, Schmid B, Nielsen TT, Nielsen JE, Clausen C, Hyttel P, Holst B, Freude KK. Stem Cell Res. 2016 Jun 16;17(1):151-153. doi: 10.1016/j.scr.2016.06.005. PubMed
CRISPR/Cas9-mediated knockout of p22phox leads to loss of Nox1 and Nox4, but not Nox5 activity. Prior KK, Leisegang MS, Josipovic I, Lowe O, Shah AM, Weissmann N, Schroder K, Brandes RP. Redox Biol. 2016 Oct;9:287-295. doi: 10.1016/j.redox.2016.08.013. Epub 2016 Aug 24. PubMed
Mutagenesis and Genome Engineering of Epstein-Barr Virus in Cultured Human Cells by CRISPR/Cas9. Yuen KS, Chan CP, Kok KH, Jin DY. Methods Mol Biol. 2017;1498:23-31. PubMed
Activation of the ATR kinase by the RPA-binding protein ETAA1. Haahr P, Hoffmann S, Tollenaere MA, Ho T, Toledo LI, Mann M, Bekker-Jensen S, Raschle M, Mailand N. Nat Cell Biol. 2016 Nov;18(11):1196-1207. doi: 10.1038/ncb3422. Epub 2016 Oct 10. PubMed
Super-resolution imaging of fluorescently labeled, endogenous RNA Polymerase II in living cells with CRISPR/Cas9-mediated gene editing. Cho WK, Jayanth N, Mullen S, Tan TH, Jung YJ, Cisse II. Sci Rep. 2016 Oct 26;6:35949. doi: 10.1038/srep35949. PubMed
Generation of a gene-corrected isogenic control hiPSC line derived from a familial Alzheimer's disease patient carrying a L150P mutation in presenilin 1. Poon A, Schmid B, Pires C, Nielsen TT, Hjermind LE, Nielsen JE, Holst B, Hyttel P, Freude KK. Stem Cell Res. 2016 Sep 24;17(3):466-469. doi: 10.1016/j.scr.2016.09.018. PubMed
Generation of an isogenic, gene-corrected iPSC line from a symptomatic 57-year-old female patient with frontotemporal dementia caused by a P301L mutation in the microtubule associated protein tau (MAPT) gene. Nimsanor N, Kitiyanant N, Poulsen U, Rasmussen MA, Clausen C, Mau-Holzmann UA, Nielsen JE, Nielsen TT, Hyttel P, Holst B, Schmid B. Stem Cell Res. 2016 Sep 28;17(3):556-559. doi: 10.1016/j.scr.2016.09.021. PubMed
Control of apico-basal epithelial polarity by the microtubule minus-end-binding protein CAMSAP3 and spectraplakin ACF7. Noordstra I, Liu Q, Nijenhuis W, Hua S, Jiang K, Baars M, Remmelzwaal S, Martin M, Kapitein LC, Akhmanova A. J Cell Sci. 2016 Nov 15;129(22):4278-4288. Epub 2016 Oct 17. PubMed
FMN2 Makes Perinuclear Actin to Protect Nuclei during Confined Migration and Promote Metastasis. Skau CT, Fischer RS, Gurel P, Thiam HR, Tubbs A, Baird MA, Davidson MW, Piel M, Alushin GM, Nussenzweig A, Steeg PS, Waterman CM. Cell. 2016 Dec 1;167(6):1571-1585.e18. doi: 10.1016/j.cell.2016.10.023. Epub 2016 Nov 10. PubMed
A Novel Regulatory Mechanism of Type II Collagen Expression via a SOX9-dependent Enhancer in Intron 6. Yasuda H, Oh CD, Chen D, de Crombrugghe B, Kim JH. J Biol Chem. 2017 Jan 13;292(2):528-538. doi: 10.1074/jbc.M116.758425. Epub 2016 Nov 23. PubMed
Metabolic reprogramming and AMPKalpha1 pathway activation by caulerpin in colorectal cancer cells. Yu H, Zhang H, Dong M, Wu Z, Shen Z, Xie Y, Kong Z, Dai X, Xu B. Int J Oncol. 2017 Jan;50(1):161-172. doi: 10.3892/ijo.2016.3794. Epub 2016 Dec 6. PubMed
Generation of an isogenic, gene-corrected iPSC line from a symptomatic 59-year-old female patient with frontotemporal dementia caused by an R406W mutation in the microtubule associated protein tau (MAPT) gene. Nimsanor N, Poulsen U, Rasmussen MA, Clausen C, Mau-Holzmann UA, Nielsen JE, Nielsen TT, Hyttel P, Holst B, Schmid B. Stem Cell Res. 2016 Sep 28;17(3):576-579. doi: 10.1016/j.scr.2016.09.020. PubMed
Generation of an isogenic, gene-corrected iPSC line from a pre-symptomatic 28-year-old woman with an R406W mutation in the microtubule associated protein tau (MAPT) gene. Nimsanor N, Poulsen U, Rasmussen MA, Clausen C, Mau-Holzmann UA, Nielsen JE, Nielsen TT, Hyttel P, Holst B, Schmid B. Stem Cell Res. 2016 Sep 28;17(3):600-602. doi: 10.1016/j.scr.2016.09.024. PubMed
Visualizing the dynamic coupling of claudin strands to the actin cytoskeleton through ZO-1. Van Itallie CM, Tietgens AJ, Anderson JM. Mol Biol Cell. 2016 Dec 14. pii: mbc.E16-10-0698. PubMed
Phosphorylation by NLK inhibits YAP-14-3-3-interactions and induces its nuclear localization. Moon S, Kim W, Kim S, Kim Y, Song Y, Bilousov O, Kim J, Lee T, Cha B, Kim M, Kim H, Katanaev VL, Jho EH. EMBO Rep. 2017 Jan;18(1):61-71. doi: 10.15252/embr.201642683. Epub 2016 Dec 15. PubMed
The Effector Cig57 Hijacks FCHO-Mediated Vesicular Trafficking to Facilitate Intracellular Replication of Coxiella burnetii. Latomanski EA, Newton P, Khoo CA, Newton HJ. PLoS Pathog. 2016 Dec 21;12(12):e1006101. doi: 10.1371/journal.ppat.1006101. eCollection 2016 Dec. PubMed
CRISPR/Cas9-mediated integration enables TAG-eCLIP of endogenously tagged RNA binding proteins. Van Nostrand EL, Gelboin-Burkhart C, Wang R, Pratt GA, Blue SM, Yeo GW. Methods. 2016 Dec 18. pii: S1046-2023(16)30481-9. doi: 10.1016/j.ymeth.2016.12.007. PubMed
Reduced IL-37 Production Increases Spontaneous Chemokine Expressions in Colon Epithelial Cells. Gunaltay S, Ghiboub M, Hultgren O, Hornquist EH. Dig Dis Sci. 2017 May;62(5):1204-1215. doi: 10.1007/s10620-016-4422-9. Epub 2017 Jan 2. PubMed
Blood pressure-associated polymorphism controls ARHGAP42 expression via serum response factor DNA binding. Bai X, Mangum KD, Dee RA, Stouffer GA, Lee CR, Oni-Orisan A, Patterson C, Schisler JC, Viera AJ, Taylor JM, Mack CP. J Clin Invest. 2017 Feb 1;127(2):670-680. doi: 10.1172/JCI88899. Epub 2017 Jan 23. PubMed
The evolutionary capacitor HSP90 buffers the regulatory effects of mammalian endogenous retroviruses. Hummel B, Hansen EC, Yoveva A, Aprile-Garcia F, Hussong R, Sawarkar R. Nat Struct Mol Biol. 2017 Mar;24(3):234-242. doi: 10.1038/nsmb.3368. Epub 2017 Jan 30. PubMed
Platelet activating factor-induced expression of p21 is correlated with histone acetylation. Damiani E, Puebla-Osorio N, Lege BM, Liu J, Neelapu SS, Ullrich SE. Sci Rep. 2017 Feb 3;7:41959. doi: 10.1038/srep41959. PubMed
Interaction Landscape of Inherited Polymorphisms with Somatic Events in Cancer. Carter H, Marty R, Hofree M, Gross AM, Jensen J, Fisch KM, Wu X, DeBoever C, Van Nostrand EL, Song Y, Wheeler E, Kreisberg JF, Lippman SM, Yeo GW, Gutkind JS, Ideker T. Cancer Discov. 2017 Apr;7(4):410-423. doi: 10.1158/2159-8290.CD-16-1045. Epub 2017 Feb 10. PubMed
A fast method for analyzing essential protein mutants in human cells. Dietsch F, Donzeau M, Cordonnier AM, Weiss E, Chatton B, Vigneron M. Biotechniques. 2017 Feb 1;62(2):80-82. doi: 10.2144/000114518. PubMed
Pervasive translational regulation of the cell signalling circuitry underlies mammalian development. Fujii K, Shi Z, Zhulyn O, Denans N, Barna M. Nat Commun. 2017 Feb 14;8:14443. doi: 10.1038/ncomms14443. PubMed
Systematic in vivo inactivation of chromatin regulating enzymes identifies Setd2 as a potent tumor suppressor in lung adenocarcinoma. Walter DM, Venancio OS, Buza EL, Tobias JW, Deshpande C, Gudiel AA, Kim-Kiselak C, Cicchini M, Yates TJ, Feldser DM. Cancer Res. 2017 Feb 15. pii: canres.2159.2016. doi: 10.1158/0008-5472.CAN-16-2159. PubMed Associated Plasmids LentiCRISPRv2Cre LentiCRISPRv2GFP
Patient iPSC-Derived Neurons for Disease Modeling of Frontotemporal Dementia with Mutation in CHMP2B. Zhang Y, Schmid B, Nikolaisen NK, Rasmussen MA, Aldana BI, Agger M, Calloe K, Stummann TC, Larsen HM, Nielsen TT, Huang J, Xu F, Liu X, Bolund L, Meyer M, Bak LK, Waagepetersen HS, Luo Y, Nielsen JE, Holst B, Clausen C, Hyttel P, Freude KK. Stem Cell Reports. 2017 Mar 14;8(3):648-658. doi: 10.1016/j.stemcr.2017.01.012. Epub 2017 Feb 16. PubMed
CTCF participates in DNA damage response via poly(ADP-ribosyl)ation. Han D, Chen Q, Shi J, Zhang F, Yu X. Sci Rep. 2017 Mar 6;7:43530. doi: 10.1038/srep43530. PubMed
Sensing of Bacterial Cyclic Dinucleotides by the Oxidoreductase RECON Promotes NF-kappaB Activation and Shapes a Proinflammatory Antibacterial State. McFarland AP, Luo S, Ahmed-Qadri F, Zuck M, Thayer EF, Goo YA, Hybiske K, Tong L, Woodward JJ. Immunity. 2017 Mar 21;46(3):433-445. doi: 10.1016/j.immuni.2017.02.014. PubMed
DHX9 suppresses RNA processing defects originating from the Alu invasion of the human genome. Aktas T, Avsar Ilik I, Maticzka D, Bhardwaj V, Pessoa Rodrigues C, Mittler G, Manke T, Backofen R, Akhtar A. Nature. 2017 Apr 6;544(7648):115-119. doi: 10.1038/nature21715. Epub 2017 Mar 29. PubMed
Dissection of ubiquitinated protein degradation by basal autophagy. Takayama K, Matsuura A, Itakura E. FEBS Lett. 2017 May;591(9):1199-1211. doi: 10.1002/1873-3468.12641. Epub 2017 Apr 18. PubMed
Psip1/p52 regulates posterior Hoxa genes through activation of lncRNA Hottip. Pradeepa MM, McKenna F, Taylor GC, Bengani H, Grimes GR, Wood AJ, Bhatia S, Bickmore WA. PLoS Genet. 2017 Apr 6;13(4):e1006677. doi: 10.1371/journal.pgen.1006677. eCollection 2017 Apr. PubMed
Proteolysis of mature HIV-1 p6 Gag protein by the insulin-degrading enzyme (IDE) regulates virus replication in an Env-dependent manner. Hahn F, Schmalen A, Setz C, Friedrich M, Schlosser S, Kolle J, Spranger R, Rauch P, Fraedrich K, Reif T, Karius-Fischer J, Balasubramanyam A, Henklein P, Fossen T, Schubert U. PLoS One. 2017 Apr 7;12(4):e0174254. doi: 10.1371/journal.pone.0174254. eCollection 2017. PubMed
Generating stable cell lines with quantifiable protein production using CRISPR/Cas9-mediated knock-in. Lo CA, Greben AW, Chen BE. Biotechniques. 2017 Apr 1;62(4):165-174. doi: 10.2144/000114534. PubMed
Electric Cell-Substrate Impedance Sensing To Monitor Viral Growth and Study Cellular Responses to Infection with Alphaherpesviruses in Real Time. Pennington MR, Van de Walle GR. mSphere. 2017 Apr 5;2(2). pii: e00039-17. doi: 10.1128/mSphere.00039-17. eCollection 2017 Mar-Apr. PubMed
A new inhibitor of the beta-arrestin/AP2 endocytic complex reveals interplay between GPCR internalization and signalling. Beautrait A, Paradis JS, Zimmerman B, Giubilaro J, Nikolajev L, Armando S, Kobayashi H, Yamani L, Namkung Y, Heydenreich FM, Khoury E, Audet M, Roux PP, Veprintsev DB, Laporte SA, Bouvier M. Nat Commun. 2017 Apr 18;8:15054. doi: 10.1038/ncomms15054. PubMed
Frameshift indels introduced by genome editing can lead to in-frame exon skipping. Lalonde S, Stone OA, Lessard S, Lavertu A, Desjardins J, Beaudoin M, Rivas M, Stainier DYR, Lettre G. PLoS One. 2017 Jun 1;12(6):e0178700. doi: 10.1371/journal.pone.0178700. eCollection 2017. PubMed
Histone demethylase KDM5A regulates the ZMYND8-NuRD chromatin remodeler to promote DNA repair. Gong F, Clouaire T, Aguirrebengoa M, Legube G, Miller KM. J Cell Biol. 2017 Jul 3;216(7):1959-1974. doi: 10.1083/jcb.201611135. Epub 2017 Jun 1. PubMed
CRISPR/Cas9-Mediated Correction of the FANCD1 Gene in Primary Patient Cells. Skvarova Kramarzova K, Osborn MJ, Webber BR, DeFeo AP, McElroy AN, Kim CJ, Tolar J. Int J Mol Sci. 2017 Jun 14;18(6). pii: E1269. doi: 10.3390/ijms18061269. PubMed
Regulated Erlin-dependent release of the B12 transmembrane J-protein promotes ER membrane penetration of a non-enveloped virus. Inoue T, Tsai B. PLoS Pathog. 2017 Jun 14;13(6):e1006439. doi: 10.1371/journal.ppat.1006439. eCollection 2017 Jun. PubMed
Sexually dimorphic distribution of Prokr2 neurons revealed by the Prokr2-Cre mouse model. Mohsen Z, Sim H, Garcia-Galiano D, Han X, Bellefontaine N, Saunders TL, Elias CF. Brain Struct Funct. 2017 Jun 14. doi: 10.1007/s00429-017-1456-5. PubMed
Optimizing the DNA Donor Template for Homology-Directed Repair of Double-Strand Breaks. Song F, Stieger K. Mol Ther Nucleic Acids. 2017 Jun 16;7:53-60. doi: 10.1016/j.omtn.2017.02.006. Epub 2017 Feb 28. PubMed
Baculoviral delivery of CRISPR/Cas9 facilitates efficient genome editing in human cells. Hindriksen S, Bramer AJ, Truong MA, Vromans MJM, Post JB, Verlaan-Klink I, Snippert HJ, Lens SMA, Hadders MA. PLoS One. 2017 Jun 22;12(6):e0179514. doi: 10.1371/journal.pone.0179514. eCollection 2017. PubMed
Genome Editing in Mouse Zygotes and Embryonic Stem Cells by Introducing SgRNA/Cas9 Expressing Plasmids. Noda T, Oji A, Ikawa M. Methods Mol Biol. 2017;1630:67-80. doi: 10.1007/978-1-4939-7128-2_6. PubMed
TSPAN12 Is a Norrin Co-receptor that Amplifies Frizzled4 Ligand Selectivity and Signaling. Lai MB, Zhang C, Shi J, Johnson V, Khandan L, McVey J, Klymkowsky MW, Chen Z, Junge HJ. Cell Rep. 2017 Jun 27;19(13):2809-2822. doi: 10.1016/j.celrep.2017.06.004. PubMed Associated Plasmids pcDNA 3.3 HA-hTSPAN12 pcDNA 3.3 HA-TSPAN12^11-LEL pcDNA 3.3 EGFP pcDNA 3.3 ss-V5-hFZD4 (aa 37-537) pcDNA3.3 ss-3xFLAG-hLRP5 (aa 32-1615) More ...
Generation of Genomic Deletions (of Rig-I GENE) in Goat Primary Cell Culture Using CRISPR/CAS9 Method. Malpotra S, Vats A, Kumar S, Gautam D, De S. Anim Biotechnol. 2018 Apr 3;29(2):142-152. doi: 10.1080/10495398.2017.1331915. Epub 2017 Jun 29. PubMed
Norrin-induced Frizzled4 endocytosis and endo-lysosomal trafficking control retinal angiogenesis and barrier function. Zhang C, Lai MB, Khandan L, Lee LA, Chen Z, Junge HJ. Nat Commun. 2017 Jul 4;8:16050. doi: 10.1038/ncomms16050. PubMed
Physiological and pathophysiological control of synaptic GluN2B-NMDA receptors by the C-terminal domain of amyloid precursor protein. Pousinha PA, Mouska X, Raymond EF, Gwizdek C, Dhib G, Poupon G, Zaragosi LE, Giudici C, Bethus I, Pacary E, Willem M, Marie H. Elife. 2017 Jul 6;6. doi: 10.7554/eLife.25659. PubMed Associated Plasmids pAAV-AICD-NLS-IRES-hrGFP pAAV-AICD-NES-IRES-hrGFP pAAV-APLP1ICD-IRES-hrGFP pAAV-syn-AICD-IRES-hrGFP pAAV-syn-IRES-hrGFP
The Protein Encoded by the CCDC170 Breast Cancer Gene Functions to Organize the Golgi-Microtubule Network. Jiang P, Li Y, Poleshko A, Medvedeva V, Baulina N, Zhang Y, Zhou Y, Slater CM, Pellegrin T, Wasserman J, Lindy M, Efimov A, Daly M, Katz RA, Chen X. EBioMedicine. 2017 Jun 27. pii: S2352-3964(17)30259-1. doi: 10.1016/j.ebiom.2017.06.024. PubMed
Inactivation of Pol theta and C-NHEJ eliminates off-target integration of exogenous DNA. Zelensky AN, Schimmel J, Kool H, Kanaar R, Tijsterman M. Nat Commun. 2017 Jul 7;8(1):66. doi: 10.1038/s41467-017-00124-3. PubMed
Wnt-Dependent Inactivation of the Groucho/TLE Co-repressor by the HECT E3 Ubiquitin Ligase Hyd/UBR5. Flack JE, Mieszczanek J, Novcic N, Bienz M. Mol Cell. 2017 Jul 20;67(2):181-193.e5. doi: 10.1016/j.molcel.2017.06.009. Epub 2017 Jul 6. PubMed
In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target. Manguso RT, Pope HW, Zimmer MD, Brown FD, Yates KB, Miller BC, Collins NB, Bi K, LaFleur MW, Juneja VR, Weiss SA, Lo J, Fisher DE, Miao D, Van Allen E, Root DE, Sharpe AH, Doench JG, Haining WN. Nature. 2017 Jul 27;547(7664):413-418. doi: 10.1038/nature23270. Epub 2017 Jul 19. PubMed
Knockdown of EPHA1 Using CRISPR/CAS9 Suppresses Aggressive Properties of Ovarian Cancer Cells. Cui Y, Wu BO, Flamini V, Evans BAJ, Zhou D, Jiang WG. Anticancer Res. 2017 Aug;37(8):4415-4424. doi: 10.21873/anticanres.11836. PubMed
A Becn1 mutation mediates hyperactive autophagic sequestration of amyloid oligomers and improved cognition in Alzheimer's disease. Rocchi A, Yamamoto S, Ting T, Fan Y, Sadleir K, Wang Y, Zhang W, Huang S, Levine B, Vassar R, He C. PLoS Genet. 2017 Aug 14;13(8):e1006962. doi: 10.1371/journal.pgen.1006962. eCollection 2017 Aug. PubMed Associated Plasmids lenti-HA-mBec1 lenti-HA-mBec1 F121A
miR-322 stabilizes MEK1 expression to inhibit RAF/MEK/ERK pathway activation in cartilage. Bluhm B, Ehlen HWA, Holzer T, Georgieva VS, Heilig J, Pitzler L, Etich J, Bortecen T, Frie C, Probst K, Niehoff A, Belluoccio D, Van den Bergen J, Brachvogel B. Development. 2017 Oct 1;144(19):3562-3577. doi: 10.1242/dev.148429. Epub 2017 Aug 29. PubMed
A subset of conserved mammalian long non-coding RNAs are fossils of ancestral protein-coding genes. Hezroni H, Ben-Tov Perry R, Meir Z, Housman G, Lubelsky Y, Ulitsky I. Genome Biol. 2017 Aug 30;18(1):162. doi: 10.1186/s13059-017-1293-0. PubMed
The calcium-binding protein ALG-2 regulates protein secretion and trafficking via interactions with MISSL and MAP1B proteins. Takahara T, Inoue K, Arai Y, Kuwata K, Shibata H, Maki M. J Biol Chem. 2017 Oct 13;292(41):17057-17072. doi: 10.1074/jbc.M117.800201. Epub 2017 Sep 1. PubMed
Drusen in patient-derived hiPSC-RPE models of macular dystrophies. Galloway CA, Dalvi S, Hung SSC, MacDonald LA, Latchney LR, Wong RCB, Guymer RH, Mackey DA, Williams DS, Chung MM, Gamm DM, Pebay A, Hewitt AW, Singh R. Proc Natl Acad Sci U S A. 2017 Sep 26;114(39):E8214-E8223. doi: 10.1073/pnas.1710430114. Epub 2017 Sep 6. PubMed
Scc2/Nipbl hops between chromosomal cohesin rings after loading. Rhodes J, Mazza D, Nasmyth K, Uphoff S. Elife. 2017 Sep 15;6. pii: 30000. doi: 10.7554/eLife.30000. PubMed
Cohesin Can Remain Associated with Chromosomes during DNA Replication. Rhodes JDP, Haarhuis JHI, Grimm JB, Rowland BD, Lavis LD, Nasmyth KA. Cell Rep. 2017 Sep 19;20(12):2749-2755. doi: 10.1016/j.celrep.2017.08.092. PubMed
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A simple and rapid approach to develop recombinant avian herpesvirus vectored vaccines using CRISPR/Cas9 system. Tang N, Zhang Y, Pedrera M, Chang P, Baigent S, Moffat K, Shen Z, Nair V, Yao Y. Vaccine. 2018 Jan 29;36(5):716-722. doi: 10.1016/j.vaccine.2017.12.025. Epub 2018 Jan 2. PubMed
An engineered cell line lacking OGG1 and MUTYH glycosylases implicates the accumulation of genomic 8-oxoguanine as the basis for paraquat mutagenicity. Tajai P, Fedeles BI, Suriyo T, Navasumrit P, Kanitwithayanun J, Essigmann JM, Satayavivad J. Free Radic Biol Med. 2018 Feb 20;116:64-72. doi: 10.1016/j.freeradbiomed.2017.12.035. Epub 2017 Dec 28. PubMed
CCPG1 Is a Non-canonical Autophagy Cargo Receptor Essential for ER-Phagy and Pancreatic ER Proteostasis. Smith MD, Harley ME, Kemp AJ, Wills J, Lee M, Arends M, von Kriegsheim A, Behrends C, Wilkinson S. Dev Cell. 2018 Jan 22;44(2):217-232.e11. doi: 10.1016/j.devcel.2017.11.024. Epub 2017 Dec 28. PubMed
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Issues with the Specificity of Immunological Reagents for NLRP3: Implications for Age-related Macular Degeneration. Kosmidou C, Efstathiou NE, Hoang MV, Notomi S, Konstantinou EK, Hirano M, Takahashi K, Maidana DE, Tsoka P, Young L, Gragoudas ES, Olsen TW, Morizane Y, Miller JW, Vavvas DG. Sci Rep. 2018 Jan 11;8(1):461. doi: 10.1038/s41598-017-17634-1. PubMed
Targeting mutant KRAS with CRISPR-Cas9 controls tumor growth. Kim W, Lee S, Kim HS, Song M, Cha YH, Kim YH, Shin J, Lee ES, Joo Y, Song JJ, Choi EJ, Choi JW, Lee J, Kang M, Yook JI, Lee MG, Kim YS, Paik S, Kim HH. Genome Res. 2018 Jan 11. pii: gr.223891.117. doi: 10.1101/gr.223891.117. PubMed
Role of miR-203 in estrogen receptor-mediated signaling in the rat uterus and endometrial carcinoma. Zierau O, Helle J, Schadyew S, Morgenroth Y, Bentler M, Hennig A, Chittur S, Tenniswood M, Kretzschmar G. J Cell Biochem. 2018 Jan 13. doi: 10.1002/jcb.26675. PubMed
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Human IFIT3 Modulates IFIT1 RNA Binding Specificity and Protein Stability. Johnson B, VanBlargan LA, Xu W, White JP, Shan C, Shi PY, Zhang R, Adhikari J, Gross ML, Leung DW, Diamond MS, Amarasinghe GK. Immunity. 2018 Mar 20;48(3):487-499.e5. doi: 10.1016/j.immuni.2018.01.014. Epub 2018 Mar 8. PubMed
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Mental Illnesses-Associated Fxr1 and Its Negative Regulator Gsk3beta Are Modulators of Anxiety and Glutamatergic Neurotransmission. Khlghatyan J, Evstratova A, Chamberland S, Marakhovskaia A, Bahremand A, Toth K, Beaulieu JM. Front Mol Neurosci. 2018 Apr 12;11:119. doi: 10.3389/fnmol.2018.00119. eCollection 2018. PubMed Associated Plasmids pAAV hSyn GFP-Fxr1 pAAV Gsk3 sgRNA/GFP
RNA Helicase DDX1 Converts RNA G-Quadruplex Structures into R-Loops to Promote IgH Class Switch Recombination. Ribeiro de Almeida C, Dhir S, Dhir A, Moghaddam AE, Sattentau Q, Meinhart A, Proudfoot NJ. Mol Cell. 2018 May 17;70(4):650-662.e8. doi: 10.1016/j.molcel.2018.04.001. Epub 2018 May 3. PubMed
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qSR: a quantitative super-resolution analysis tool reveals the cell-cycle dependent organization of RNA Polymerase I in live human cells. Andrews JO, Conway W, Cho W-, Narayanan A, Spille J-, Jayanth N, Inoue T, Mullen S, Thaler J, Cisse II. Sci Rep. 2018 May 9;8(1):7424. doi: 10.1038/s41598-018-25454-0. PubMed
PRDX1 and MTH1 cooperate to prevent ROS-mediated inhibition of telomerase. Ahmed W, Lingner J. Genes Dev. 2018 May 1;32(9-10):658-669. doi: 10.1101/gad.313460.118. Epub 2018 May 17. PubMed
Hyaluronan negatively regulates vascular calcification involving BMP2 signaling. Kong Y, Liang Q, Chen Y, Yang P, Liu X, Li Y, Feng S, Wu J, Liu W, Tang J, Yu H, Ou JS, Lu L, Yan J. Lab Invest. 2018 Oct;98(10):1320-1332. doi: 10.1038/s41374-018-0076-x. Epub 2018 May 21. PubMed
High-throughput screening of prostate cancer risk loci by single nucleotide polymorphisms sequencing. Zhang P, Xia JH, Zhu J, Gao P, Tian YJ, Du M, Guo YC, Suleman S, Zhang Q, Kohli M, Tillmans LS, Thibodeau SN, French AJ, Cerhan JR, Wang LD, Wei GH, Wang L. Nat Commun. 2018 May 22;9(1):2022. doi: 10.1038/s41467-018-04451-x. PubMed
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Naturally Occurring Variants in LRP1 (Low-Density Lipoprotein Receptor-Related Protein 1) Affect HDL (High-Density Lipoprotein) Metabolism Through ABCA1 (ATP-Binding Cassette A1) and SR-B1 (Scavenger Receptor Class B Type 1) in Humans. Oldoni F, van Capelleveen JC, Dalila N, Wolters JC, Heeren J, Sinke RJ, Hui DY, Dallinga-Thie GM, Frikke-Schmidt R, Hovingh KG, van de Sluis B, Tybjaerg-Hansen A, Kuivenhoven JA. Arterioscler Thromb Vasc Biol. 2018 Jul;38(7):1440-1453. doi: 10.1161/ATVBAHA.117.310309. Epub 2018 May 31. PubMed
Development of a Reporter System to Explore MMEJ in the Context of Replacing Large Genomic Fragments. Yanik M, Ponnam SPG, Wimmer T, Trimborn L, Muller C, Gambert I, Ginsberg J, Janise A, Domicke J, Wende W, Lorenz B, Stieger K. Mol Ther Nucleic Acids. 2018 Jun 1;11:407-415. doi: 10.1016/j.omtn.2018.03.010. Epub 2018 Mar 22. PubMed
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gamma-Secretase promotes membrane insertion of the human papillomavirus L2 capsid protein during virus infection. Inoue T, Zhang P, Zhang W, Goodner-Bingham K, Dupzyk A, DiMaio D, Tsai B. J Cell Biol. 2018 Oct 1;217(10):3545-3559. doi: 10.1083/jcb.201804171. Epub 2018 Jul 13. PubMed
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Tumor endothelial marker 8 promotes cancer progression and metastasis. Hoye AM, Tolstrup SD, Horton ER, Nicolau M, Frost H, Woo JH, Mauldin JP, Frankel AE, Cox TR, Erler JT. Oncotarget. 2018 Jul 10;9(53):30173-30188. doi: 10.18632/oncotarget.25734. eCollection 2018 Jul 10. PubMed
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Probing the Function of Oncohistones Using Mutant Transgenes and Knock-In Mutations. Fang D, Wang H, Zhang Z. Methods Mol Biol. 2018;1832:339-356. doi: 10.1007/978-1-4939-8663-7_19. PubMed
Disruption by SaCas9 Endonuclease of HERV-Kenv, a Retroviral Gene with Oncogenic and Neuropathogenic Potential, Inhibits Molecules Involved in Cancer and Amyotrophic Lateral Sclerosis. Ibba G, Piu C, Uleri E, Serra C, Dolei A. Viruses. 2018 Aug 7;10(8). pii: v10080412. doi: 10.3390/v10080412. PubMed
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PARP2 mediates branched poly ADP-ribosylation in response to DNA damage. Chen Q, Kassab MA, Dantzer F, Yu X. Nat Commun. 2018 Aug 13;9(1):3233. doi: 10.1038/s41467-018-05588-5. PubMed
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CRISPR/Cas9-Mediated Generation of Guangxi Bama Minipigs Harboring Three Mutations in alpha-Synuclein Causing Parkinson's Disease. Zhu XX, Zhong YZ, Ge YW, Lu KH, Lu SS. Sci Rep. 2018 Aug 20;8(1):12420. doi: 10.1038/s41598-018-30436-3. PubMed
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Facultative dosage compensation of developmental genes on autosomes in Drosophila and mouse embryonic stem cells. Valsecchi CIK, Basilicata MF, Semplicio G, Georgiev P, Gutierrez NM, Akhtar A. Nat Commun. 2018 Sep 7;9(1):3626. doi: 10.1038/s41467-018-05642-2. PubMed
Staufen1 links RNA stress granules and autophagy in a model of neurodegeneration. Paul S, Dansithong W, Figueroa KP, Scoles DR, Pulst SM. Nat Commun. 2018 Sep 7;9(1):3648. doi: 10.1038/s41467-018-06041-3. PubMed
A CRISPR/Cas9 platform for MS2-labelling of single mRNA in live stem cells. Spille JH, Hecht M, Grube V, Cho WK, Lee C, Cisse II. Methods. 2019 Jan 15;153:35-45. doi: 10.1016/j.ymeth.2018.09.004. Epub 2018 Sep 12. PubMed
Sensitive and rapid quantification of exosomes by fusing luciferase to exosome marker proteins. Hikita T, Miyata M, Watanabe R, Oneyama C. Sci Rep. 2018 Sep 19;8(1):14035. doi: 10.1038/s41598-018-32535-7. PubMed
Genome Engineering of Hybridomas to Generate Stable Cell Lines for Antibody Expression. Parola C, Mason DM, Zingg A, Neumeier D, Reddy ST. Methods Mol Biol. 2018;1850:79-111. doi: 10.1007/978-1-4939-8730-6_7. PubMed
Loperamide, pimozide, and STF-62247 trigger autophagy-dependent cell death in glioblastoma cells. Zielke S, Meyer N, Mari M, Abou-El-Ardat K, Reggiori F, van Wijk SJL, Kogel D, Fulda S. Cell Death Dis. 2018 Sep 24;9(10):994. doi: 10.1038/s41419-018-1003-1. PubMed
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Manifold roles of beta-arrestins in GPCR signaling elucidated with siRNA and CRISPR/Cas9. Luttrell LM, Wang J, Plouffe B, Smith JS, Yamani L, Kaur S, Jean-Charles PY, Gauthier C, Lee MH, Pani B, Kim J, Ahn S, Rajagopal S, Reiter E, Bouvier M, Shenoy SK, Laporte SA, Rockman HA, Lefkowitz RJ. Sci Signal. 2018 Sep 25;11(549). pii: 11/549/eaat7650. doi: 10.1126/scisignal.aat7650. PubMed
Inflammation-associated miR-155 activates differentiation of muscular satellite cells. Onodera Y, Teramura T, Takehara T, Itokazu M, Mori T, Fukuda K. PLoS One. 2018 Oct 1;13(10):e0204860. doi: 10.1371/journal.pone.0204860. eCollection 2018. PubMed
OTUB1 non-catalytically stabilizes the E2 ubiquitin-conjugating enzyme UBE2E1 by preventing its autoubiquitination. Pasupala N, Morrow ME, Que LT, Malynn BA, Ma A, Wolberger C. J Biol Chem. 2018 Nov 23;293(47):18285-18295. doi: 10.1074/jbc.RA118.004677. Epub 2018 Oct 3. PubMed Associated Plasmids FLAG-OTUB1 WT-pcDNA3.1 FLAG-OTUB1 C91S-pcDNA3.1 FLAG-OTUB1 T134R-pcDNA3.1 FLAG-OTUB1 T134R,C91S-pcDNA3.1 HA-UBE2E1 WT in pcDNA3.1 More ...
Combined Experimental and System-Level Analyses Reveal the Complex Regulatory Network of miR-124 during Human Neurogenesis. Kutsche LK, Gysi DM, Fallmann J, Lenk K, Petri R, Swiersy A, Klapper SD, Pircs K, Khattak S, Stadler PF, Jakobsson J, Nowick K, Busskamp V. Cell Syst. 2018 Sep 28. pii: S2405-4712(18)30358-2. doi: 10.1016/j.cels.2018.08.011. PubMed Associated Plasmids PB09-TRE-beta-globin-miR-124-EF1a-GFP PB09-TRE-beta-globin-miR-ctrl-EF1a-GFP PB09-TRE-ZNF787_G379A pSMPUW-miR-124-GFP-Puro pSpCas9(BB)-2A-Puro (PX459)+gRNA miR-124-1/2-5' More ...
Human SEIPIN Binds Anionic Phospholipids. Yan R, Qian H, Lukmantara I, Gao M, Du X, Yan N, Yang H. Dev Cell. 2018 Oct 22;47(2):248-256.e4. doi: 10.1016/j.devcel.2018.09.010. Epub 2018 Oct 4. PubMed
CRISPR-mediated deletion of prostate cancer risk-associated CTCF loop anchors identifies repressive chromatin loops. Guo Y, Perez AA, Hazelett DJ, Coetzee GA, Rhie SK, Farnham PJ. Genome Biol. 2018 Oct 8;19(1):160. doi: 10.1186/s13059-018-1531-0. PubMed
A polymorphic residue that attenuates the antiviral potential of interferon lambda 4 in hominid lineages. Bamford CGG, Aranday-Cortes E, Filipe IC, Sukumar S, Mair D, Filipe ADS, Mendoza JL, Garcia KC, Fan S, Tishkoff SA, McLauchlan J. PLoS Pathog. 2018 Oct 11;14(10):e1007307. doi: 10.1371/journal.ppat.1007307. eCollection 2018 Oct. PubMed
Thyroid hormone signaling specifies cone subtypes in human retinal organoids. Eldred KC, Hadyniak SE, Hussey KA, Brenerman B, Zhang PW, Chamling X, Sluch VM, Welsbie DS, Hattar S, Taylor J, Wahlin K, Zack DJ, Johnston RJ Jr. Science. 2018 Oct 12;362(6411). pii: 362/6411/eaau6348. doi: 10.1126/science.aau6348. PubMed
High fidelity CRISPR/Cas9 increases precise monoallelic and biallelic editing events in primordial germ cells. Idoko-Akoh A, Taylor L, Sang HM, McGrew MJ. Sci Rep. 2018 Oct 11;8(1):15126. doi: 10.1038/s41598-018-33244-x. PubMed Associated Plasmids HF-PX459 (V2)
Probing aggrephagy using chemically-induced protein aggregates. Janssen AFJ, Katrukha EA, van Straaten W, Verlhac P, Reggiori F, Kapitein LC. Nat Commun. 2018 Oct 12;9(1):4245. doi: 10.1038/s41467-018-06674-4. PubMed Associated Plasmids pBA-mCherry-EGFP-PIM pGW1-mCherry-EGFP-PIM
Albatross/FBF1 contributes to both centriole duplication and centrosome separation. Inoko A, Yano T, Miyamoto T, Matsuura S, Kiyono T, Goshima N, Inagaki M, Hayashi Y. Genes Cells. 2018 Dec;23(12):1023-1042. doi: 10.1111/gtc.12648. Epub 2018 Nov 13. PubMed
Tracing the transitions from pluripotency to germ cell fate with CRISPR screening. Hackett JA, Huang Y, Gunesdogan U, Gretarsson KA, Kobayashi T, Surani MA. Nat Commun. 2018 Oct 16;9(1):4292. doi: 10.1038/s41467-018-06230-0. PubMed
A methyl-sensitive element induces bidirectional transcription in TATA-less CpG island-associated promoters. Mahpour A, Scruggs BS, Smiraglia D, Ouchi T, Gelman IH. PLoS One. 2018 Oct 17;13(10):e0205608. doi: 10.1371/journal.pone.0205608. eCollection 2018. PubMed
The epilepsy-associated protein TBC1D24 is required for normal development, survival and vesicle trafficking in mammalian neurons. Finelli MJ, Aprile D, Castroflorio E, Jeans A, Moschetta M, Chessum L, Degiacomi MT, Grasegger J, Lupien-Meilleur A, Bassett A, Rossignol E, Campeau PM, Bowl MR, Benfenati F, Fassio A, Oliver PL. Hum Mol Genet. 2019 Feb 15;28(4):584-597. doi: 10.1093/hmg/ddy370. PubMed
Up-regulated miR-133a orchestrates epithelial-mesenchymal transition of airway epithelial cells. Chen L, He X, Xie Y, Huang Y, Wolff DW, Abel PW, Tu Y. Sci Rep. 2018 Oct 19;8(1):15543. doi: 10.1038/s41598-018-33913-x. PubMed
betaTrCP is Required for HIV-1 Vpu Modulation of CD4, GaLV Env, and BST-2/Tetherin. Song YE, Cyburt D, Lucas TM, Gregory DA, Lyddon TD, Johnson MC. Viruses. 2018 Oct 19;10(10). pii: v10100573. doi: 10.3390/v10100573. PubMed
EHD2 is a mechanotransducer connecting caveolae dynamics with gene transcription. Torrino S, Shen WW, Blouin CM, Mani SK, Viaris de Lesegno C, Bost P, Grassart A, Koster D, Valades-Cruz CA, Chambon V, Johannes L, Pierobon P, Soumelis V, Coirault C, Vassilopoulos S, Lamaze C. J Cell Biol. 2018 Dec 3;217(12):4092-4105. doi: 10.1083/jcb.201801122. Epub 2018 Oct 22. PubMed
The Development and Use of Scalable Systems for Studying Aberrant Splicing in SF3B1-Mutant CLL. Murthy T, Paul KV, Minella AC, Pillai MM. Methods Mol Biol. 2019;1881:83-99. doi: 10.1007/978-1-4939-8876-1_7. PubMed
Analysis of the relationship between the KRAS G12V oncogene and the Hippo effector YAP1 in embryonal rhabdomyosarcoma. Mohamed AD, Shah N, Hettmer S, Vargesson N, Wackerhage H. Sci Rep. 2018 Oct 23;8(1):15674. doi: 10.1038/s41598-018-33852-7. PubMed
Transdifferentiation of Muscle Satellite Cells to Adipose Cells Using CRISPR/Cas9-Mediated Targeting of MyoD. Chen J, Wang C, Kuang S. Methods Mol Biol. 2019;1889:25-41. doi: 10.1007/978-1-4939-8897-6_3. PubMed
Reciprocal inhibition of YAP/TAZ and NF-kappaB regulates osteoarthritic cartilage degradation. Deng Y, Lu J, Li W, Wu A, Zhang X, Tong W, Ho KK, Qin L, Song H, Mak KK. Nat Commun. 2018 Nov 1;9(1):4564. doi: 10.1038/s41467-018-07022-2. PubMed
p53-dependent autophagic degradation of TET2 modulates cancer therapeutic resistance. Zhang J, Tan P, Guo L, Gong J, Ma J, Li J, Lee M, Fang S, Jing J, Johnson G, Sun D, Cao WM, Dashwood R, Han L, Zhou Y, Dong WG, Huang Y. Oncogene. 2019 Mar;38(11):1905-1919. doi: 10.1038/s41388-018-0524-5. Epub 2018 Nov 2. PubMed
Genomic sequencing and editing revealed the GRM8 signaling pathway as potential therapeutic targets of squamous cell lung cancer. Zhang P, Kang B, Xie G, Li S, Gu Y, Shen Y, Zhao X, Ma Y, Li F, Si J, Wang J, Chen J, Yang H, Xu X, Yang Y. Cancer Lett. 2019 Feb 1;442:53-67. doi: 10.1016/j.canlet.2018.10.035. Epub 2018 Oct 27. PubMed
Critical Role of the UBL Domain in Stimulating the E3 Ubiquitin Ligase Activity of UHRF1 toward Chromatin. Foster BM, Stolz P, Mulholland CB, Montoya A, Kramer H, Bultmann S, Bartke T. Mol Cell. 2018 Nov 15;72(4):739-752.e9. doi: 10.1016/j.molcel.2018.09.028. Epub 2018 Nov 1. PubMed
Activity of the SPCA1 Calcium Pump Couples Sphingomyelin Synthesis to Sorting of Secretory Proteins in the Trans-Golgi Network. Deng Y, Pakdel M, Blank B, Sundberg EL, Burd CG, von Blume J. Dev Cell. 2018 Nov 19;47(4):464-478.e8. doi: 10.1016/j.devcel.2018.10.012. Epub 2018 Nov 1. PubMed
A Screen Using iPSC-Derived Hepatocytes Reveals NAD(+) as a Potential Treatment for mtDNA Depletion Syndrome. Jing R, Corbett JL, Cai J, Beeson GC, Beeson CC, Chan SS, Dimmock DP, Lazcares L, Geurts AM, Lemasters JJ, Duncan SA. Cell Rep. 2018 Nov 6;25(6):1469-1484.e5. doi: 10.1016/j.celrep.2018.10.036. PubMed
Examining the role of the surfactant family member SFTA3 in interneuron specification. Chen CY, Anderson NC, Becker S, Schicht M, Stoddard C, Brauer L, Paulsen F, Grabel L. PLoS One. 2018 Nov 8;13(11):e0198703. doi: 10.1371/journal.pone.0198703. eCollection 2018. PubMed
Dynamic nanoscale morphology of the ER surveyed by STED microscopy. Schroeder LK, Barentine AES, Merta H, Schweighofer S, Zhang Y, Baddeley D, Bewersdorf J, Bahmanyar S. J Cell Biol. 2019 Jan 7;218(1):83-96. doi: 10.1083/jcb.201809107. Epub 2018 Nov 15. PubMed
Loss of the Chr16p11.2 ASD candidate gene QPRT leads to aberrant neuronal differentiation in the SH-SY5Y neuronal cell model. Haslinger D, Waltes R, Yousaf A, Lindlar S, Schneider I, Lim CK, Tsai MM, Garvalov BK, Acker-Palmer A, Krezdorn N, Rotter B, Acker T, Guillemin GJ, Fulda S, Freitag CM, Chiocchetti AG. Mol Autism. 2018 Nov 6;9:56. doi: 10.1186/s13229-018-0239-z. eCollection 2018. PubMed
Degenerate minigene library analysis enables identification of altered branch point utilization by mutant splicing factor 3B1 (SF3B1). Gupta AK, Murthy T, Paul KV, Ramirez O, Fisher JB, Rao S, Rosenberg AB, Seelig G, Minella AC, Pillai MM. Nucleic Acids Res. 2018 Nov 20. pii: 5193340. doi: 10.1093/nar/gky1161. PubMed Associated Plasmids sgSf3b1(T1) pL452-Sf3b1-K700E pL452(hygro)-Sf3b1-K700K
hnRNP Q Regulates Internal Ribosome Entry Site-Mediated fmr1 Translation in Neurons. Choi JH, Kim SH, Jeong YH, Kim SW, Min KT, Kim KT. Mol Cell Biol. 2019 Feb 4;39(4). pii: MCB.00371-18. doi: 10.1128/MCB.00371-18. Print 2019 Feb 15. PubMed
Structural basis of RIP2 activation and signaling. Gong Q, Long Z, Zhong FL, Teo DET, Jin Y, Yin Z, Boo ZZ, Zhang Y, Zhang J, Yang R, Bhushan S, Reversade B, Li Z, Wu B. Nat Commun. 2018 Nov 26;9(1):4993. doi: 10.1038/s41467-018-07447-9. PubMed
The Tumor Suppressor SASH1 Interacts With the Signal Adaptor CRKL to Inhibit Epithelial-Mesenchymal Transition and Metastasis in Colorectal Cancer. Franke FC, Muller J, Abal M, Medina ED, Nitsche U, Weidmann H, Chardonnet S, Ninio E, Janssen KP. Cell Mol Gastroenterol Hepatol. 2018 Sep 11;7(1):33-53. doi: 10.1016/j.jcmgh.2018.08.007. eCollection 2019. PubMed
Lysophospholipases cooperate to mediate lipid homeostasis and lysophospholipid signaling. Wepy JA, Galligan JJ, Kingsley PJ, Xu S, Goodman MC, Tallman KA, Rouzer CA, Marnett LJ. J Lipid Res. 2019 Feb;60(2):360-374. doi: 10.1194/jlr.M087890. Epub 2018 Nov 27. PubMed
Highly efficient scarless knock-in of reporter genes into human and mouse pluripotent stem cells via transient antibiotic selection. Sluch VM, Chamling X, Wenger C, Duan Y, Rice DS, Zack DJ. PLoS One. 2018 Nov 29;13(11):e0201683. doi: 10.1371/journal.pone.0201683. eCollection 2018. PubMed
Mitochondrial One-Carbon Pathway Supports Cytosolic Folate Integrity in Cancer Cells. Zheng Y, Lin TY, Lee G, Paddock MN, Momb J, Cheng Z, Li Q, Fei DL, Stein BD, Ramsamooj S, Zhang G, Blenis J, Cantley LC. Cell. 2018 Nov 29;175(6):1546-1560.e17. doi: 10.1016/j.cell.2018.09.041. PubMed
CD4+ T cells induce rejection of urothelial tumors after immune checkpoint blockade. Sato Y, Bolzenius JK, Eteleeb AM, Su X, Maher CA, Sehn JK, Arora VK. JCI Insight. 2018 Dec 6;3(23). pii: 121062. doi: 10.1172/jci.insight.121062. PubMed
RNA-seq Analysis of the SCN1A-KO Model based on CRISPR/Cas9 Genome Editing Technology. Shi X, He W, Guo S, Zhang B, Ren S, Liu K, Sun T, Cui J. Neuroscience. 2019 Feb 1;398:1-11. doi: 10.1016/j.neuroscience.2018.11.052. Epub 2018 Dec 8. PubMed
Heterochromatin delays CRISPR-Cas9 mutagenesis but does not influence the outcome of mutagenic DNA repair. Kallimasioti-Pazi EM, Thelakkad Chathoth K, Taylor GC, Meynert A, Ballinger T, Kelder MJE, Lalevee S, Sanli I, Feil R, Wood AJ. PLoS Biol. 2018 Dec 12;16(12):e2005595. doi: 10.1371/journal.pbio.2005595. eCollection 2018 Dec. PubMed
The sterol-responsive RNF145 E3 ubiquitin ligase mediates the degradation of HMG-CoA reductase together with gp78 and Hrd1. Menzies SA, Volkmar N, van den Boomen DJ, Timms RT, Dickson AS, Nathan JA, Lehner PJ. Elife. 2018 Dec 13;7. pii: 40009. doi: 10.7554/eLife.40009. PubMed
Intracellular Iron Chelation by a Novel Compound, C7, Reactivates Epstein(-)Barr Virus (EBV) Lytic Cycle via the ERK-Autophagy Axis in EBV-Positive Epithelial Cancers. Yiu SPT, Hui KF, Choi CK, Kao RYT, Ma CW, Yang D, Chiang AKS. Cancers (Basel). 2018 Dec 11;10(12). pii: cancers10120505. doi: 10.3390/cancers10120505. PubMed
A selective ER-phagy exerts procollagen quality control via a Calnexin-FAM134B complex. Forrester A, De Leonibus C, Grumati P, Fasana E, Piemontese M, Staiano L, Fregno I, Raimondi A, Marazza A, Bruno G, Iavazzo M, Intartaglia D, Seczynska M, van Anken E, Conte I, De Matteis MA, Dikic I, Molinari M, Settembre C. EMBO J. 2019 Jan 15;38(2). pii: embj.201899847. doi: 10.15252/embj.201899847. Epub 2018 Dec 17. PubMed
Improved Delivery of CRISPR/Cas9 System Using Magnetic Nanoparticles into Porcine Fibroblast. Hryhorowicz M, Grzeskowiak B, Mazurkiewicz N, Sledzinski P, Lipinski D, Slomski R. Mol Biotechnol. 2019 Mar;61(3):173-180. doi: 10.1007/s12033-018-0145-9. PubMed
Hippo Pathway Regulation by Tyrosine Kinases. Reuven N, Shanzer M, Shaul Y. Methods Mol Biol. 2019;1893:215-236. doi: 10.1007/978-1-4939-8910-2_17. PubMed
Synthetic mammalian pattern formation driven by differential diffusivity of Nodal and Lefty. Sekine R, Shibata T, Ebisuya M. Nat Commun. 2018 Dec 21;9(1):5456. doi: 10.1038/s41467-018-07847-x. PubMed
CRISPR/Cas9-mediated knockout of the PDEF gene inhibits migration and invasion of human gastric cancer AGS cells. Zhang YQ, Pei JH, Shi SS, Guo XS, Cui GY, Li YF, Zhang HP, Hu WQ. Biomed Pharmacother. 2019 Mar;111:76-85. doi: 10.1016/j.biopha.2018.12.048. Epub 2018 Dec 19. PubMed
The ER membrane protein complex promotes biogenesis of sterol-related enzymes maintaining cholesterol homeostasis. Volkmar N, Thezenas ML, Louie SM, Juszkiewicz S, Nomura DK, Hegde RS, Kessler BM, Christianson JC. J Cell Sci. 2019 Jan 16;132(2). pii: jcs.223453. doi: 10.1242/jcs.223453. PubMed
Disruption of sialic acid metabolism drives tumor growth by augmenting CD8(+) T cell apoptosis. Cornelissen LAM, Blanas A, van der Horst JC, Kruijssen L, Zaal A, O'Toole T, Wiercx L, van Kooyk Y, van Vliet SJ. Int J Cancer. 2019 May 1;144(9):2290-2302. doi: 10.1002/ijc.32084. Epub 2019 Jan 3. PubMed
TULP3 is required for localization of membrane-associated proteins ARL13B and INPP5E to primary cilia. Han S, Miyoshi K, Shikada S, Amano G, Wang Y, Yoshimura T, Katayama T. Biochem Biophys Res Commun. 2019 Jan 29;509(1):227-234. doi: 10.1016/j.bbrc.2018.12.109. Epub 2018 Dec 21. PubMed
The TFAP2C-Regulated OCT4 Naive Enhancer Is Involved in Human Germline Formation. Chen D, Liu W, Zimmerman J, Pastor WA, Kim R, Hosohama L, Ho J, Aslanyan M, Gell JJ, Jacobsen SE, Clark AT. Cell Rep. 2018 Dec 26;25(13):3591-3602.e5. doi: 10.1016/j.celrep.2018.12.011. PubMed
Engagement of DNA and H3K27me3 by the CBX8 chromodomain drives chromatin association. Connelly KE, Weaver TM, Alpsoy A, Gu BX, Musselman CA, Dykhuizen EC. Nucleic Acids Res. 2018 Dec 29. pii: 5266947. doi: 10.1093/nar/gky1290. PubMed Associated Plasmids Fuw CBX8 Fuw CBX8 R19A Fuw CBX8 R20A Fuw CBX8 R22A Fuw CBX8 3xRA More ...
Dengue virus requires apoptosis linked gene-2-interacting protein X (ALIX) for viral propagation. Thepparit C, Khongwichit S, Ketsuwan K, Libsittikul S, Auewarakul P, Smith DR. Virus Res. 2019 Feb;261:65-71. doi: 10.1016/j.virusres.2018.12.015. Epub 2018 Dec 29. PubMed
CD46 Null Packaging Cell Line Improves Measles Lentiviral Vector Production and Gene Delivery to Hematopoietic Stem and Progenitor Cells. Ozog S, Chen CX, Simpson E, Garijo O, Timberlake ND, Minder P, Verhoeyen E, Torbett BE. Mol Ther Methods Clin Dev. 2018 Nov 24;13:27-39. doi: 10.1016/j.omtm.2018.11.006. eCollection 2019 Jun 14. PubMed
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Defining the Functional Role of NaV1.7 in Human Nociception. McDermott LA, Weir GA, Themistocleous AC, Segerdahl AR, Blesneac I, Baskozos G, Clark AJ, Millar V, Peck LJ, Ebner D, Tracey I, Serra J, Bennett DL. Neuron. 2019 Mar 6;101(5):905-919.e8. doi: 10.1016/j.neuron.2019.01.047. Epub 2019 Feb 19. PubMed
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ATG2 transports lipids to promote autophagosome biogenesis. Valverde DP, Yu S, Boggavarapu V, Kumar N, Lees JA, Walz T, Reinisch KM, Melia TJ. J Cell Biol. 2019 Jun 3;218(6):1787-1798. doi: 10.1083/jcb.201811139. Epub 2019 Apr 5. PubMed
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NIPSNAP1 and NIPSNAP2 Act as "Eat Me" Signals for Mitophagy. Princely Abudu Y, Pankiv S, Mathai BJ, Hakon Lystad A, Bindesboll C, Brenne HB, Yoke Wui Ng M, Thiede B, Yamamoto A, Mutugi Nthiga T, Lamark T, Esguerra CV, Johansen T, Simonsen A. Dev Cell. 2019 May 20;49(4):509-525.e12. doi: 10.1016/j.devcel.2019.03.013. Epub 2019 Apr 11. PubMed
Kruppel-like factor 5 (Klf5) regulates expression of mouse T1R1 amino acid receptor gene (Tas1r1) in C2C12 myoblast cells. Hirata Y, Toyono T, Kokabu S, Obikane Y, Kataoka S, Nakatomi M, Masaki C, Hosokawa R, Seta Y. Biomed Res. 2019;40(2):67-78. doi: 10.2220/biomedres.40.67. PubMed
BRCA1-associated R-loop affects transcription and differentiation in breast luminal epithelial cells. Chiang HC, Zhang X, Li J, Zhao X, Chen J, Wang HT, Jatoi I, Brenner A, Hu Y, Li R. Nucleic Acids Res. 2019 Jun 4;47(10):5086-5099. doi: 10.1093/nar/gkz262. PubMed
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Phosphoregulation of the oncogenic protein regulator of cytokinesis 1 (PRC1) by the atypical CDK16/CCNY complex. Hernandez-Ortega S, Sanchez-Botet A, Quandt E, Masip N, Gasa L, Verde G, Jimenez J, Levin RS, Rutaganira FU, Burlingame AL, Wolfgeher D, Ribeiro MPC, Kron SJ, Shokat KM, Clotet J. Exp Mol Med. 2019 Apr 16;51(4):44. doi: 10.1038/s12276-019-0242-2. PubMed
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Zfp281 Shapes the Transcriptome of Trophoblast Stem Cells and Is Essential for Placental Development. Ishiuchi T, Ohishi H, Sato T, Kamimura S, Yorino M, Abe S, Suzuki A, Wakayama T, Suyama M, Sasaki H. Cell Rep. 2019 May 7;27(6):1742-1754.e6. doi: 10.1016/j.celrep.2019.04.028. PubMed
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Phosphorylation-dependent Regnase-1 release from endoplasmic reticulum is critical in IL-17 response. Tanaka H, Arima Y, Kamimura D, Tanaka Y, Takahashi N, Uehata T, Maeda K, Satoh T, Murakami M, Akira S. J Exp Med. 2019 Jun 3;216(6):1431-1449. doi: 10.1084/jem.20181078. Epub 2019 May 9. PubMed
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p90 ribosomal S6 kinase (RSK) phosphorylates myosin phosphatase and thereby controls edge dynamics during cell migration. Samson SC, Elliott A, Mueller BD, Kim Y, Carney KR, Bergman JP, Blenis J, Mendoza MC. J Biol Chem. 2019 Jul 12;294(28):10846-10862. doi: 10.1074/jbc.RA119.007431. Epub 2019 May 28. PubMed
ERCC1/XPF Is Important for Repair of DNA Double-Strand Breaks Containing Secondary Structures. Li S, Lu H, Wang Z, Hu Q, Wang H, Xiang R, Chiba T, Wu X. iScience. 2019 Jun 28;16:63-78. doi: 10.1016/j.isci.2019.05.017. Epub 2019 May 16. PubMed
Species specific differences in use of ANP32 proteins by influenza A virus. Long JS, Idoko-Akoh A, Mistry B, Goldhill D, Staller E, Schreyer J, Ross C, Goodbourn S, Shelton H, Skinner MA, Sang H, McGrew MJ, Barclay W. Elife. 2019 Jun 4;8. pii: 45066. doi: 10.7554/eLife.45066. PubMed
Generation of focal mutations and large genomic deletions in the pancreas using inducible in vivo genome editing. Mishra A, Emamgholi F, Erlangga Z, Hartleben B, Unger K, Wolff K, Teichmann U, Kessel M, Woller N, Kuhnel F, Dow LE, Manns MP, Vogel A, Lowe SW, Saborowski A, Saborowski M. Carcinogenesis. 2019 Jun 6. pii: 5512083. doi: 10.1093/carcin/bgz108. PubMed
ASB6 Promotes the Stemness Properties and Sustains Metastatic Potential of Oral Squamous Cell Carcinoma Cells by Attenuating ER Stress. Hung KF, Liao PC, Chen CK, Chiu YT, Cheng DH, Kawasumi M, Kao SY, Lo JF. Int J Biol Sci. 2019 Apr 22;15(5):1080-1090. doi: 10.7150/ijbs.31484. eCollection 2019. PubMed
Hyaluronan synthesis supports glutamate transporter activity. Hayashi MK, Nishioka T, Shimizu H, Takahashi K, Kakegawa W, Mikami T, Hirayama Y, Koizumi S, Yoshida S, Yuzaki M, Tammi M, Sekino Y, Kaibuchi K, Shigemoto-Mogami Y, Yasui M, Sato K. J Neurochem. 2019 Aug;150(3):249-263. doi: 10.1111/jnc.14791. Epub 2019 Jul 9. PubMed
ZEB1 insufficiency causes corneal endothelial cell state transition and altered cellular processing. Frausto RF, Chung DD, Boere PM, Swamy VS, Duong HNV, Kao L, Azimov R, Zhang W, Carrigan L, Wong D, Morselli M, Zakharevich M, Hanser EM, Kassels AC, Kurtz I, Pellegrini M, Aldave AJ. PLoS One. 2019 Jun 13;14(6):e0218279. doi: 10.1371/journal.pone.0218279. eCollection 2019. PubMed
Modeling microcephaly with cerebral organoids reveals a WDR62-CEP170-KIF2A pathway promoting cilium disassembly in neural progenitors. Zhang W, Yang SL, Yang M, Herrlinger S, Shao Q, Collar JL, Fierro E, Shi Y, Liu A, Lu H, Herring BE, Guo ML, Buch S, Zhao Z, Xu J, Lu Z, Chen JF. Nat Commun. 2019 Jun 13;10(1):2612. doi: 10.1038/s41467-019-10497-2. PubMed
CRISPR/Cas9-mediated genome editing reveals 30 testis-enriched genes dispensable for male fertility in mice. Lu Y, Oura S, Matsumura T, Oji A, Sakurai N, Fujihara Y, Shimada K, Miyata H, Tobita T, Noda T, Castaneda JM, Kiyozumi D, Zhang Q, Larasati T, Young SAM, Kodani M, Huddleston CA, Robertson MJ, Coarfa C, Isotani A, Aitken RJ, Okabe M, Matzuk MM, Garcia TX, Ikawa M. Biol Reprod. 2019 Jun 14. pii: 5519226. doi: 10.1093/biolre/ioz103. PubMed
A novel histone H4 variant H4G regulates rDNA transcription in breast cancer. Long M, Sun X, Shi W, Yanru A, Leung STC, Ding D, Cheema MS, MacPherson N, Nelson CJ, Ausio J, Yan Y, Ishibashi T. Nucleic Acids Res. 2019 Jun 20. pii: 5521031. doi: 10.1093/nar/gkz547. PubMed
Functional Interrogation of Lynch Syndrome Associated MSH2 Missense Variants via CRISPR-Cas9 Gene Editing in Human Embryonic Stem Cells. Rath A, Mishra A, Ferreira VD, Hu C, Omerza G, Kelly K, Hesse A, Reddi HV, Grady JP, Heinen CD. Hum Mutat. 2019 Jun 25. doi: 10.1002/humu.23848. PubMed
HSF2BP Interacts with a Conserved Domain of BRCA2 and Is Required for Mouse Spermatogenesis. Brandsma I, Sato K, van Rossum-Fikkert SE, van Vliet N, Sleddens E, Reuter M, Odijk H, van den Tempel N, Dekkers DHW, Bezstarosti K, Demmers JAA, Maas A, Lebbink J, Wyman C, Essers J, van Gent DC, Baarends WM, Knipscheer P, Kanaar R, Zelensky AN. Cell Rep. 2019 Jun 25;27(13):3790-3798.e7. doi: 10.1016/j.celrep.2019.05.096. PubMed
TRAF3 Is Required for NF-kappaB Pathway Activation Mediated by HTLV Tax Proteins. Fochi S, Bergamo E, Serena M, Mutascio S, Journo C, Mahieux R, Ciminale V, Bertazzoni U, Zipeto D, Romanelli MG. Front Microbiol. 2019 Jun 12;10:1302. doi: 10.3389/fmicb.2019.01302. eCollection 2019. PubMed
Enhancer-mediated enrichment of interacting JMJD3-DDX21 to ENPP2 locus prevents R-loop formation and promotes transcription. Argaud D, Boulanger MC, Chignon A, Mkannez G, Mathieu P. Nucleic Acids Res. 2019 Jun 28. pii: 5525060. doi: 10.1093/nar/gkz560. PubMed
Poly(ADP-ribose) polymerase-1 antagonizes DNA resection at double-strand breaks. Caron MC, Sharma AK, O'Sullivan J, Myler LR, Ferreira MT, Rodrigue A, Coulombe Y, Ethier C, Gagne JP, Langelier MF, Pascal JM, Finkelstein IJ, Hendzel MJ, Poirier GG, Masson JY. Nat Commun. 2019 Jul 4;10(1):2954. doi: 10.1038/s41467-019-10741-9. PubMed
Identification of the m(6)Am Methyltransferase PCIF1 Reveals the Location and Functions of m(6)Am in the Transcriptome. Boulias K, Toczydlowska-Socha D, Hawley BR, Liberman N, Takashima K, Zaccara S, Guez T, Vasseur JJ, Debart F, Aravind L, Jaffrey SR, Greer EL. Mol Cell. 2019 Jun 20. pii: S1097-2765(19)30439-3. doi: 10.1016/j.molcel.2019.06.006. PubMed
CATACOMB: An endogenous inducible gene that antagonizes H3K27 methylation activity of Polycomb repressive complex 2 via an H3K27M-like mechanism. Piunti A, Smith ER, Morgan MAJ, Ugarenko M, Khaltyan N, Helmin KA, Ryan CA, Murray DC, Rickels RA, Yilmaz BD, Rendleman EJ, Savas JN, Singer BD, Bulun SE, Shilatifard A. Sci Adv. 2019 Jul 3;5(7):eaax2887. doi: 10.1126/sciadv.aax2887. eCollection 2019 Jul. PubMed
Deletion of Tet proteins results in quantitative disparities during ESC differentiation partially attributable to alterations in gene expression. Reimer M Jr, Pulakanti K, Shi L, Abel A, Liang M, Malarkannan S, Rao S. BMC Dev Biol. 2019 Jul 8;19(1):16. doi: 10.1186/s12861-019-0196-6. PubMed
IL-1RA is part of the inflammasome-regulated immune response in bladder epithelial cells and influences colonization of uropathogenic E. coli. Lindblad A, Persson K, Demirel I. Cytokine. 2019 Nov;123:154772. doi: 10.1016/j.cyto.2019.154772. Epub 2019 Jul 9. PubMed
LC3-positive structures are prominent in autophagy-deficient cells. Runwal G, Stamatakou E, Siddiqi FH, Puri C, Zhu Y, Rubinsztein DC. Sci Rep. 2019 Jul 12;9(1):10147. doi: 10.1038/s41598-019-46657-z. PubMed
Human ATG4 autophagy proteases counteract attachment of ubiquitin-like LC3/GABARAP proteins to other cellular proteins. Agrotis A, von Chamier L, Oliver H, Kiso K, Singh T, Ketteler R. J Biol Chem. 2019 Jul 17. pii: AC119.009977. doi: 10.1074/jbc.AC119.009977. PubMed Associated Plasmids pCMV 3xFLAG-LC3B Q116P G120 pDEST-CMV GFP-LC3B Q116P G120 pDONR223 LC3B Q116P G120 pDONR223 ATG3 WT pDONR223 ATG3 C264A More ...
NQO1 targeting prodrug triggers innate sensing to overcome checkpoint blockade resistance. Li X, Liu Z, Zhang A, Han C, Shen A, Jiang L, Boothman DA, Qiao J, Wang Y, Huang X, Fu YX. Nat Commun. 2019 Jul 19;10(1):3251. doi: 10.1038/s41467-019-11238-1. PubMed
RNase L Induces Expression of A Novel Serine/Threonine Protein Kinase, DRAK1, to Promote Apoptosis. Manivannan P, Reddy V, Mukherjee S, Clark KN, Malathi K. Int J Mol Sci. 2019 Jul 19;20(14). pii: ijms20143535. doi: 10.3390/ijms20143535. PubMed
Depletion of phosphatidylinositol 4-phosphate at the Golgi translocates K-Ras to mitochondria. Miller TE, Henkels KM, Huddleston M, Salisbury R, Hussain SM, Sasaki AT, Cho KJ. J Cell Sci. 2019 Aug 22;132(16). pii: jcs.231886. doi: 10.1242/jcs.231886. PubMed
Wnt Signaling Modulates Routes of Retinoic Acid-Induced Differentiation of Embryonic Stem Cells. Wang S, Huang H, Xiang H, Gu B, Li W, Chen L, Zhang M. Stem Cells Dev. 2019 Oct 1;28(19):1334-1345. doi: 10.1089/scd.2019.0065. Epub 2019 Aug 27. PubMed
Identification of an emphysema-associated genetic variant near TGFB2 with regulatory effects in lung fibroblasts. Parker MM, Hao Y, Guo F, Pham B, Chase R, Platig J, Cho MH, Hersh CP, Thannickal VJ, Crapo J, Washko G, Randell SH, Silverman EK, San Jose Estepar R, Zhou X, Castaldi PJ. Elife. 2019 Jul 25;8. pii: 42720. doi: 10.7554/eLife.42720. PubMed
12-Lipoxygenase Regulates Cold Adaptation and Glucose Metabolism by Producing the Omega-3 Lipid 12-HEPE from Brown Fat. Leiria LO, Wang CH, Lynes MD, Yang K, Shamsi F, Sato M, Sugimoto S, Chen EY, Bussberg V, Narain NR, Sansbury BE, Darcy J, Huang TL, Kodani SD, Sakaguchi M, Rocha AL, Schulz TJ, Bartelt A, Hotamisligil GS, Hirshman MF, van Leyen K, Goodyear LJ, Bluher M, Cypess AM, Kiebish MA, Spite M, Tseng YH. Cell Metab. 2019 Oct 1;30(4):768-783.e7. doi: 10.1016/j.cmet.2019.07.001. Epub 2019 Jul 25. PubMed
Cell sensing and decision-making in confinement: The role of TRPM7 in a tug of war between hydraulic pressure and cross-sectional area. Zhao R, Afthinos A, Zhu T, Mistriotis P, Li Y, Serra SA, Zhang Y, Yankaskas CL, He S, Valverde MA, Sun SX, Konstantopoulos K. Sci Adv. 2019 Jul 24;5(7):eaaw7243. doi: 10.1126/sciadv.aaw7243. eCollection 2019 Jul. PubMed
KDM2 proteins constrain transcription from CpG island gene promoters independently of their histone demethylase activity. Turberfield AH, Kondo T, Nakayama M, Koseki Y, King HW, Koseki H, Klose RJ. Nucleic Acids Res. 2019 Sep 26;47(17):9005-9023. doi: 10.1093/nar/gkz607. PubMed
CRISPR/Cas9-Mediated Knockout and In Situ Inversion of the ORF57 Gene from All Copies of the Kaposi's Sarcoma-Associated Herpesvirus Genome in BCBL-1 Cells. BeltCappellino A, Majerciak V, Lobanov A, Lack J, Cam M, Zheng ZM. J Virol. 2019 Oct 15;93(21). pii: JVI.00628-19. doi: 10.1128/JVI.00628-19. Print 2019 Nov 1. PubMed
Identification of multiple male reproductive tract-specific proteins that regulate sperm migration through the oviduct in mice. Fujihara Y, Noda T, Kobayashi K, Oji A, Kobayashi S, Matsumura T, Larasati T, Oura S, Kojima-Kita K, Yu Z, Matzuk MM, Ikawa M. Proc Natl Acad Sci U S A. 2019 Sep 10;116(37):18498-18506. doi: 10.1073/pnas.1908736116. Epub 2019 Aug 27. PubMed
Addiction associated N40D mu-opioid receptor variant modulates synaptic function in human neurons. Halikere A, Popova D, Scarnati MS, Hamod A, Swerdel MR, Moore JC, Tischfield JA, Hart RP, Pang ZP. Mol Psychiatry. 2019 Sep 3. pii: 10.1038/s41380-019-0507-0. doi: 10.1038/s41380-019-0507-0. PubMed
ZCCHC8, the nuclear exosome targeting component, is mutated in familial pulmonary fibrosis and is required for telomerase RNA maturation. Gable DL, Gaysinskaya V, Atik CC, Talbot CC Jr, Kang B, Stanley SE, Pugh EW, Amat-Codina N, Schenk KM, Arcasoy MO, Brayton C, Florea L, Armanios M. Genes Dev. 2019 Oct 1;33(19-20):1381-1396. doi: 10.1101/gad.326785.119. Epub 2019 Sep 5. PubMed
Functional diversification of hybridoma-produced antibodies by CRISPR/HDR genomic engineering. van der Schoot JMS, Fennemann FL, Valente M, Dolen Y, Hagemans IM, Becker AMD, Le Gall CM, van Dalen D, Cevirgel A, van Bruggen JAC, Engelfriet M, Caval T, Bentlage AEH, Fransen MF, Nederend M, Leusen JHW, Heck AJR, Vidarsson G, Figdor CG, Verdoes M, Scheeren FA. Sci Adv. 2019 Aug 28;5(8):eaaw1822. doi: 10.1126/sciadv.aaw1822. eCollection 2019 Aug. PubMed Associated Plasmids pHybr_r2a>mG1-srt-his pHybr_r2a>mG2a-srt-his pHybr_r2a>mG2b-srt-his pHybr_r2a>mG3-srt-his pHybr_r2a>mA-srt-his More ...
Proteomics of Melanoma Response to Immunotherapy Reveals Mitochondrial Dependence. Harel M, Ortenberg R, Varanasi SK, Mangalhara KC, Mardamshina M, Markovits E, Baruch EN, Tripple V, Arama-Chayoth M, Greenberg E, Shenoy A, Ayasun R, Knafo N, Xu S, Anafi L, Yanovich-Arad G, Barnabas GD, Ashkenazi S, Besser MJ, Schachter J, Bosenberg M, Shadel GS, Barshack I, Kaech SM, Markel G, Geiger T. Cell. 2019 Sep 19;179(1):236-250.e18. doi: 10.1016/j.cell.2019.08.012. Epub 2019 Sep 5. PubMed
Comprehensive Interactome Analysis Reveals that STT3B Is Required for N-Glycosylation of Lassa Virus Glycoprotein. Zhu S, Wan W, Zhang Y, Shang W, Pan X, Zhang LK, Xiao G. J Virol. 2019 Nov 13;93(23). pii: JVI.01443-19. doi: 10.1128/JVI.01443-19. Print 2019 Dec 1. PubMed
The metabolic sensor PASK is a histone 3 kinase that also regulates H3K4 methylation by associating with H3K4 MLL2 methyltransferase complex. Karakkat JV, Kaimala S, Sreedharan SP, Jayaprakash P, Adeghate EA, Ansari SA, Guccione E, Mensah-Brown EPK, Starling Emerald B. Nucleic Acids Res. 2019 Nov 4;47(19):10086-10103. doi: 10.1093/nar/gkz786. PubMed
Weak membrane interactions allow Rheb to activate mTORC1 signaling without major lysosome enrichment. Angarola B, Ferguson SM. Mol Biol Cell. 2019 Oct 15;30(22):2750-2760. doi: 10.1091/mbc.E19-03-0146. Epub 2019 Sep 18. PubMed Associated Plasmids pEGFP-C1-RhebL1 pEGFP-C1-Rheb px459-Rheb sgRNA px459-RhebL1 sgRNA
Efficient ADCC killing of meningioma by avelumab and a high-affinity natural killer cell line, haNK. Giles AJ, Hao S, Padget M, Song H, Zhang W, Lynes J, Sanchez V, Liu Y, Jung J, Cao X, Fujii R, Jensen R, Gillespie D, Schlom J, Gilbert MR, Nduom EK, Yang C, Lee JH, Soon-Shiong P, Hodge JW, Park DM. JCI Insight. 2019 Oct 17;4(20). pii: 130688. doi: 10.1172/jci.insight.130688. PubMed
High-throughput genome-wide phenotypic screening via immunomagnetic cell sorting. Mair B, Aldridge PM, Atwal RS, Philpott D, Zhang M, Masud SN, Labib M, Tong AHY, Sargent EH, Angers S, Moffat J, Kelley SO. Nat Biomed Eng. 2019 Oct;3(10):796-805. doi: 10.1038/s41551-019-0454-8. Epub 2019 Sep 23. PubMed
DART-seq: an antibody-free method for global m(6)A detection. Meyer KD. Nat Methods. 2019 Sep 23. pii: 10.1038/s41592-019-0570-0. doi: 10.1038/s41592-019-0570-0. PubMed Associated Plasmids pCMV-APOBEC1-YTH pCMV-APOBEC1-YTHmut
Synergistic effects of common schizophrenia risk variants. Schrode N, Ho SM, Yamamuro K, Dobbyn A, Huckins L, Matos MR, Cheng E, Deans PJM, Flaherty E, Barretto N, Topol A, Alganem K, Abadali S, Gregory J, Hoelzli E, Phatnani H, Singh V, Girish D, Aronow B, Mccullumsmith R, Hoffman GE, Stahl EA, Morishita H, Sklar P, Brennand KJ. Nat Genet. 2019 Oct;51(10):1475-1485. doi: 10.1038/s41588-019-0497-5. Epub 2019 Sep 23. PubMed
NF-kappaB Activation Promotes Alphavirus Replication in Mature Neurons. Yeh JX, Park E, Schultz KLW, Griffin DE. J Virol. 2019 Nov 26;93(24). pii: JVI.01071-19. doi: 10.1128/JVI.01071-19. Print 2019 Dec 15. PubMed
MUC16 in non-small cell lung cancer patients affected by familial lung cancer and indoor air pollution: clinical characteristics and cell behaviors. Chen Y, Huang Y, Kanwal M, Li G, Yang J, Niu H, Li Z, Ding X. Transl Lung Cancer Res. 2019 Aug;8(4):476-488. doi: 10.21037/tlcr.2019.07.10. PubMed
Double-strand breakage in the extrachromosomal double minutes triggers their aggregation in the nucleus, micronucleation, and morphological transformation. Oobatake Y, Shimizu N. Genes Chromosomes Cancer. 2020 Mar;59(3):133-143. doi: 10.1002/gcc.22810. Epub 2019 Oct 4. PubMed
Optimised insert design for improved single-molecule imaging and quantification through CRISPR-Cas9 mediated knock-in. Khan AO, White CW, Pike JA, Yule J, Slater A, Hill SJ, Poulter NS, Thomas SG, Morgan NV. Sci Rep. 2019 Oct 2;9(1):14219. doi: 10.1038/s41598-019-50733-9. PubMed
Keratin 14 is a novel interaction partner of keratinocyte differentiation regulator: receptor-interacting protein kinase 4. Sumer C, Boz Er AB, Dincer T. Turk J Biol. 2019 Aug 5;43(4):225-234. doi: 10.3906/biy-1904-37. eCollection 2019. PubMed
Evaluating the efficacy of small molecules for neural differentiation of common marmoset ESCs and iPSCs. Yoshimatsu S, Nakamura M, Nakajima M, Nemoto A, Sato T, Sasaki E, Shiozawa S, Okano H. Neurosci Res. 2019 Oct 3. pii: S0168-0102(19)30262-7. doi: 10.1016/j.neures.2019.09.005. PubMed Associated Plasmids pPB-tetpA-iRPT pPB-tetpA-hNEUROG2-iRPT
Implementation of an antibody characterization procedure and application to the major ALS/FTD disease gene C9ORF72. Laflamme C, McKeever PM, Kumar R, Schwartz J, Kolahdouzan M, Chen CX, You Z, Benaliouad F, Gileadi O, McBride HM, Durcan TM, Edwards AM, Healy LM, Robertson J, McPherson PS. Elife. 2019 Oct 15;8. pii: 48363. doi: 10.7554/eLife.48363. PubMed
Mutations in the sonic hedgehog pathway cause macrocephaly-associated conditions due to crosstalk to the PI3K/AKT/mTOR pathway. Klein SD, Nguyen DC, Bhakta V, Wong D, Chang VY, Davidson TB, Martinez-Agosto JA. Am J Med Genet A. 2019 Dec;179(12):2517-2531. doi: 10.1002/ajmg.a.61368. Epub 2019 Oct 22. PubMed
The protective effects of hydrogen sulfide on the myocardial ischemia via regulating Bmal1. Hu J, Xue Y, Tang K, Fan J, Du J, Li W, Chen S, Liu C, Ji W, Liang J, Zhuang J, Chen K. Biomed Pharmacother. 2019 Dec;120:109540. doi: 10.1016/j.biopha.2019.109540. Epub 2019 Oct 19. PubMed
The RNA-binding ubiquitin ligase MKRN1 functions in ribosome-associated quality control of poly(A) translation. Hildebrandt A, Bruggemann M, Ruckle C, Boerner S, Heidelberger JB, Busch A, Hanel H, Voigt A, Mockel MM, Ebersberger S, Scholz A, Dold A, Schmid T, Ebersberger I, Roignant JY, Zarnack K, Konig J, Beli P. Genome Biol. 2019 Oct 22;20(1):216. doi: 10.1186/s13059-019-1814-0. PubMed
Genome-wide microhomologies enable precise template-free editing of biologically relevant deletion mutations. Grajcarek J, Monlong J, Nishinaka-Arai Y, Nakamura M, Nagai M, Matsuo S, Lougheed D, Sakurai H, Saito MK, Bourque G, Woltjen K. Nat Commun. 2019 Oct 24;10(1):4856. doi: 10.1038/s41467-019-12829-8. PubMed
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Vpu of a Simian Immunodeficiency Virus Isolated from Greater Spot-Nosed Monkey Antagonizes Human BST-2 via Two AxxxxxxxW Motifs. Yao W, Yoshida T, Hashimoto S, Takeuchi H, Strebel K, Yamaoka S. J Virol. 2020 Jan 6;94(2). pii: JVI.01669-19. doi: 10.1128/JVI.01669-19. Print 2020 Jan 6. PubMed
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MitoRibo-Tag Mice Provide a Tool for In Vivo Studies of Mitoribosome Composition. Busch JD, Cipullo M, Atanassov I, Bratic A, Silva Ramos E, Schondorf T, Li X, Pearce SF, Milenkovic D, Rorbach J, Larsson NG. Cell Rep. 2019 Nov 5;29(6):1728-1738.e9. doi: 10.1016/j.celrep.2019.09.080. PubMed
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Sex-dependent VEGF expression underlies variations in human pluripotent stem cell to endothelial progenitor differentiation. Randolph LN, Bao X, Oddo M, Lian XL. Sci Rep. 2019 Nov 13;9(1):16696. doi: 10.1038/s41598-019-53054-z. PubMed
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Expression of 9-O- and 7,9-O-Acetyl Modified Sialic Acid in Cells and Their Effects on Influenza Viruses. Barnard KN, Wasik BR, LaClair JR, Buchholz DW, Weichert WS, Alford-Lawrence BK, Aguilar HC, Parrish CR. mBio. 2019 Dec 3;10(6). pii: mBio.02490-19. doi: 10.1128/mBio.02490-19. PubMed
Characterization of the activity, aggregation, and toxicity of heterodimers of WT and ALS-associated mutant Sod1. Brasil AA, de Carvalho MDC, Gerhardt E, Queiroz DD, Pereira MD, Outeiro TF, Eleutherio ECA. Proc Natl Acad Sci U S A. 2019 Dec 17;116(51):25991-26000. doi: 10.1073/pnas.1902483116. Epub 2019 Dec 3. PubMed Associated Plasmids VN-SOD1 SOD1-VC
Transcriptional factor Nrf2 is essential for aggresome formation during proteasome inhibition. Qin S, Jiang C, Gao J. Biomed Rep. 2019 Dec;11(6):241-252. doi: 10.3892/br.2019.1247. Epub 2019 Oct 21. PubMed
The PAX-SIX-EYA-DACH network modulates GATA-FOG function in fly hematopoiesis and human erythropoiesis. Creed TM, Baldeosingh R, Eberly CL, Schlee CS, Kim M, Cutler JA, Pandey A, Civin CI, Fossett NG, Kingsbury TJ. Development. 2020 Jan 3;147(1). pii: dev.177022. doi: 10.1242/dev.177022. PubMed
Molecular Insights into miRNA-Driven Resistance to 5-Fluorouracil and Oxaliplatin Chemotherapy: miR-23b Modulates the Epithelial-Mesenchymal Transition of Colorectal Cancer Cells Gasiule S, Dreize N, Kaupinis A, Razanskas R, Ciupas L, Stankevicius V, Kapustina Z, Laurinavicius A, Valius M, Vilkaitis G. J Clin Med. 2019 Dec 2;8(12). pii: jcm8122115. doi: 10.3390/jcm8122115. PubMed
Simultaneous Deletion of Virulence Factors and Insertion of Antigens into the Infectious Laryngotracheitis Virus Using NHEJ-CRISPR/Cas9 and Cre-Lox System for Construction of a Stable Vaccine Vector. Atasoy MO, Rohaim MA, Munir M. Vaccines (Basel). 2019 Dec 5;7(4). pii: vaccines7040207. doi: 10.3390/vaccines7040207. PubMed
Detecting single ORAI1 proteins within the plasma membrane reveals higher-order channel complexes. Alansary D, Peckys DB, Niemeyer BA, de Jonge N. J Cell Sci. 2020 Jan 3;133(1). pii: jcs.240358. doi: 10.1242/jcs.240358. PubMed
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BMPR2 acts as a gatekeeper to protect endothelial cells from increased TGFbeta responses and altered cell mechanics. Hiepen C, Jatzlau J, Hildebrandt S, Kampfrath B, Goktas M, Murgai A, Cuellar Camacho JL, Haag R, Ruppert C, Sengle G, Cavalcanti-Adam EA, Blank KG, Knaus P. PLoS Biol. 2019 Dec 11;17(12):e3000557. doi: 10.1371/journal.pbio.3000557. eCollection 2019 Dec. PubMed
MAIT Cells Promote Tumor Initiation, Growth, and Metastases via Tumor MR1. Yan J, Allen S, McDonald E, Das I, Mak JYW, Liu L, Fairlie DP, Meehan BS, Chen Z, Corbett AJ, Varelias A, Smyth MJ, Teng MWL. Cancer Discov. 2020 Jan;10(1):124-141. doi: 10.1158/2159-8290.CD-19-0569. Epub 2019 Dec 11. PubMed
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R534C mutation in hERG causes a trafficking defect in iPSC-derived cardiomyocytes from patients with type 2 long QT syndrome. Mesquita FCP, Arantes PC, Kasai-Brunswick TH, Araujo DS, Gubert F, Monnerat G, Silva Dos Santos D, Neiman G, Leitao IC, Barbosa RAQ, Coutinho JL, Vaz IM, Dos Santos MN, Borgonovo T, Cruz FES, Miriuka S, Medei EH, Campos de Carvalho AC, Carvalho AB. Sci Rep. 2019 Dec 16;9(1):19203. doi: 10.1038/s41598-019-55837-w. PubMed
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Genetically Engineered Lung Cancer Cells for Analyzing Epithelial-Mesenchymal Transition. Kielbus M, Czapinski J, Kalafut J, Wos J, Stepulak A, Rivero-Muller A. Cells. 2019 Dec 15;8(12). pii: cells8121644. doi: 10.3390/cells8121644. PubMed
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The MITF-SOX10 regulated long non-coding RNA DIRC3 is a melanoma tumour suppressor. Coe EA, Tan JY, Shapiro M, Louphrasitthiphol P, Bassett AR, Marques AC, Goding CR, Vance KW. PLoS Genet. 2019 Dec 27;15(12):e1008501. doi: 10.1371/journal.pgen.1008501. eCollection 2019 Dec. PubMed
PRC1 Catalytic Activity Is Central to Polycomb System Function. Blackledge NP, Fursova NA, Kelley JR, Huseyin MK, Feldmann A, Klose RJ. Mol Cell. 2019 Dec 26. pii: S1097-2765(19)30892-5. doi: 10.1016/j.molcel.2019.12.001. PubMed
TCDD inhibited the osteogenic differentiation of human fetal palatal mesenchymal cells through AhR and BMP-2/TGF-beta/Smad signaling. Liu X, Li X, Tao Y, Li N, Ji M, Zhang X, Chen Y, He Z, Yu K, Yu Z. Toxicology. 2020 Feb 15;431:152353. doi: 10.1016/j.tox.2019.152353. Epub 2019 Dec 27. PubMed
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APOBEC3B reporter myeloma cell lines identify DNA damage response pathways leading to APOBEC3B expression. Yamazaki H, Shirakawa K, Matsumoto T, Kazuma Y, Matsui H, Horisawa Y, Stanford E, Sarca AD, Shirakawa R, Shindo K, Takaori-Kondo A. PLoS One. 2020 Jan 8;15(1):e0223463. doi: 10.1371/journal.pone.0223463. eCollection 2020. PubMed
ST3GAL3, ST3GAL4, and ST3GAL6 differ in their regulation of biological functions via the specificities for the alpha2,3-sialylation of target proteins. Qi F, Isaji T, Duan C, Yang J, Wang Y, Fukuda T, Gu J. FASEB J. 2020 Jan;34(1):881-897. doi: 10.1096/fj.201901793R. Epub 2019 Nov 27. PubMed
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p53 Integrates Temporal WDR5 Inputs during Neuroectoderm and Mesoderm Differentiation of Mouse Embryonic Stem Cells. Li Q, Mao F, Zhou B, Huang Y, Zou Z, denDekker AD, Xu J, Hou S, Liu J, Dou Y, Rao RC. Cell Rep. 2020 Jan 14;30(2):465-480.e6. doi: 10.1016/j.celrep.2019.12.039. PubMed
Irp2 regulates insulin production through iron-mediated Cdkal1-catalyzed tRNA modification. Santos MCFD, Anderson CP, Neschen S, Zumbrennen-Bullough KB, Romney SJ, Kahle-Stephan M, Rathkolb B, Gailus-Durner V, Fuchs H, Wolf E, Rozman J, de Angelis MH, Cai WM, Rajan M, Hu J, Dedon PC, Leibold EA. Nat Commun. 2020 Jan 15;11(1):296. doi: 10.1038/s41467-019-14004-5. PubMed
Nexin-Dynein regulatory complex component DRC7 but not FBXL13 is required for sperm flagellum formation and male fertility in mice. Morohoshi A, Miyata H, Shimada K, Nozawa K, Matsumura T, Yanase R, Shiba K, Inaba K, Ikawa M. PLoS Genet. 2020 Jan 21;16(1):e1008585. doi: 10.1371/journal.pgen.1008585. eCollection 2020 Jan. PubMed Associated Plasmids pCAG-mDrc3-PA pCAG-mGas8-PA pCAG-mTcte1-PA pCAG-mDrc7-FLAG
NBS1 is required for SPO11-linked DNA double-strand break repair in male meiosis. Zhang B, Tang Z, Li L, Lu LY. Cell Death Differ. 2020 Jul;27(7):2176-2190. doi: 10.1038/s41418-020-0493-4. Epub 2020 Jan 21. PubMed
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hnRNPDL Phase Separation Is Regulated by Alternative Splicing and Disease-Causing Mutations Accelerate Its Aggregation. Batlle C, Yang P, Coughlin M, Messing J, Pesarrodona M, Szulc E, Salvatella X, Kim HJ, Taylor JP, Ventura S. Cell Rep. 2020 Jan 28;30(4):1117-1128.e5. doi: 10.1016/j.celrep.2019.12.080. PubMed
Furry protein suppresses nuclear localization of yes-associated protein (YAP) by activating NDR kinase and binding to YAP. Irie K, Nagai T, Mizuno K. J Biol Chem. 2020 Mar 6;295(10):3017-3028. doi: 10.1074/jbc.RA119.010783. Epub 2020 Jan 29. PubMed
Ursodeoxycholic acid protects against cisplatin-induced acute kidney injury and mitochondrial dysfunction through acting on ALDH1L2. Yang Y, Liu S, Gao H, Wang P, Zhang Y, Zhang A, Jia Z, Huang S. Free Radic Biol Med. 2020 May 20;152:821-837. doi: 10.1016/j.freeradbiomed.2020.01.182. Epub 2020 Jan 28. PubMed
Glioblastomas exploit truncated O-linked glycans for local and distant immune modulation via the macrophage galactose-type lectin. Dusoswa SA, Verhoeff J, Abels E, Mendez-Huergo SP, Croci DO, Kuijper LH, de Miguel E, Wouters VMCJ, Best MG, Rodriguez E, Cornelissen LAM, van Vliet SJ, Wesseling P, Breakefield XO, Noske DP, Wurdinger T, Broekman MLD, Rabinovich GA, van Kooyk Y, Garcia-Vallejo JJ. Proc Natl Acad Sci U S A. 2020 Feb 18;117(7):3693-3703. doi: 10.1073/pnas.1907921117. Epub 2020 Feb 4. PubMed
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The phosphatidylcholine transfer protein StarD7 is important for myogenic differentiation in mouse myoblast C2C12 cells and human primary skeletal myoblasts. Horibata Y, Mitsuhashi S, Shimizu H, Maejima S, Sakamoto H, Aoyama C, Ando H, Sugimoto H. Sci Rep. 2020 Feb 18;10(1):2845. doi: 10.1038/s41598-020-59444-y. PubMed
The extracellular domain of angulin-1 and palmitoylation of its cytoplasmic region are required for angulin-1 assembly at tricellular contacts. Oda Y, Sugawara T, Fukata Y, Izumi Y, Otani T, Higashi T, Fukata M, Furuse M. J Biol Chem. 2020 Mar 27;295(13):4289-4302. doi: 10.1074/jbc.RA119.010491. Epub 2020 Feb 20. PubMed
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Vimentin Coordinates Protein Turnover at the Aggresome during Neural Stem Cell Quiescence Exit. Morrow CS, Porter TJ, Xu N, Arndt ZP, Ako-Asare K, Heo HJ, Thompson EAN, Moore DL. Cell Stem Cell. 2020 Apr 2;26(4):558-568.e9. doi: 10.1016/j.stem.2020.01.018. Epub 2020 Feb 27. PubMed
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Novel role for CRK adaptor proteins as essential components of SRC/FAK signaling for epithelial-mesenchymal transition and colorectal cancer aggressiveness. Franke FC, Slusarenko BO, Engleitner T, Johannes W, Laschinger M, Rad R, Nitsche U, Janssen KP. Int J Cancer. 2020 Sep 15;147(6):1715-1731. doi: 10.1002/ijc.32955. Epub 2020 Mar 16. PubMed
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ATP7B knockout disturbs copper and lipid metabolism in Caco-2 cells. Guttmann S, Nadzemova O, Grunewald I, Lenders M, Brand E, Zibert A, Schmidt HH. PLoS One. 2020 Mar 10;15(3):e0230025. doi: 10.1371/journal.pone.0230025. eCollection 2020. PubMed
Polyethylenimine based magnetic nanoparticles mediated non-viral CRISPR/Cas9 system for genome editing. Rohiwal SS, Dvorakova N, Klima J, Vaskovicova M, Senigl F, Slouf M, Pavlova E, Stepanek P, Babuka D, Benes H, Ellederova Z, Stieger K. Sci Rep. 2020 Mar 12;10(1):4619. doi: 10.1038/s41598-020-61465-6. PubMed
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Global Regulation of the Histone Mark H3K36me2 Underlies Epithelial Plasticity and Metastatic Progression. Yuan S, Natesan R, Sanchez-Rivera FJ, Li J, Bhanu NV, Yamazoe T, Lin JH, Merrell AJ, Sela Y, Thomas SK, Jiang Y, Plesset JB, Miller EM, Shi J, Garcia BA, Lowe SW, Asangani IA, Stanger BZ. Cancer Discov. 2020 Jun;10(6):854-871. doi: 10.1158/2159-8290.CD-19-1299. Epub 2020 Mar 18. PubMed
CRISPR/Cas9-Mediated Biallelic Knockout of IRX3 Reduces the Production and Survival of Somatic Cell-Cloned Bama Minipigs. Zhu X, Wei Y, Zhan Q, Yan A, Feng J, Liu L, Tang D. Animals (Basel). 2020 Mar 17;10(3). pii: ani10030501. doi: 10.3390/ani10030501. PubMed
A cardiomyocyte show of force: A fluorescent alpha-actinin reporter line sheds light on human cardiomyocyte contractility versus substrate stiffness. Ribeiro MC, Slaats RH, Schwach V, Rivera-Arbelaez JM, Tertoolen LGJ, van Meer BJ, Molenaar R, Mummery CL, Claessens MMAE, Passier R. J Mol Cell Cardiol. 2020 Apr;141:54-64. doi: 10.1016/j.yjmcc.2020.03.008. Epub 2020 Mar 20. PubMed
DDX39B interacts with the pattern recognition receptor pathway to inhibit NF-kappaB and sensitize to alkylating chemotherapy. Szymura SJ, Bernal GM, Wu L, Zhang Z, Crawley CD, Voce DJ, Campbell PA, Ranoa DE, Weichselbaum RR, Yamini B. BMC Biol. 2020 Mar 24;18(1):32. doi: 10.1186/s12915-020-0764-z. PubMed
Integrated analysis of miRNA and mRNA expression profiles in p53-edited PFF cells. Qiao C, Liu W, Jiang H, He M, Yang Q, Xing Y. Cell Cycle. 2020 Apr;19(8):949-959. doi: 10.1080/15384101.2020.1742852. Epub 2020 Mar 26. PubMed
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Identification of drug modifiers for RYR1-related myopathy using a multi-species discovery pipeline. Volpatti JR, Endo Y, Knox J, Groom L, Brennan S, Noche R, Zuercher WJ, Roy P, Dirksen RT, Dowling JJ. Elife. 2020 Mar 30;9. pii: 52946. doi: 10.7554/eLife.52946. PubMed
Effect of CELSR3 on the Cell Cycle and Apoptosis of Hepatocellular Carcinoma Cells. Xie Z, Dang Y, Wu H, He R, Ma J, Peng Z, Rong M, Li Z, Yang J, Jiang Y, Chen G, Yang L. J Cancer. 2020 Feb 21;11(10):2830-2844. doi: 10.7150/jca.39328. eCollection 2020. PubMed
SNP rs17079281 decreases lung cancer risk through creating an YY1-binding site to suppress DCBLD1 expression. Wang Y, Ma R, Liu B, Kong J, Lin H, Yu X, Wang R, Li L, Gao M, Zhou B, Mohan M, Yu H, Hou Z, Shen H, Qian B. Oncogene. 2020 May;39(20):4092-4102. doi: 10.1038/s41388-020-1278-4. Epub 2020 Mar 30. PubMed
Knockout of IRF7 Highlights its Modulator Function of Host Response Against Avian Influenza Virus and the Involvement of MAPK and TOR Signaling Pathways in Chicken. Kim TH, Kern C, Zhou H. Genes (Basel). 2020 Apr 2;11(4). pii: genes11040385. doi: 10.3390/genes11040385. PubMed
Human Embryonic Stem Cell-Derived Wilson's Disease Model for Screening Drug Efficacy. Kim D, Kim SB, Ryu JL, Hong H, Chang JH, Yoo TJ, Jin X, Park HJ, Han C, Lee BH, Choi JH, Yoo HW, Kim JH, Woo DH. Cells. 2020 Apr 2;9(4). pii: cells9040872. doi: 10.3390/cells9040872. PubMed
ORANGE: A CRISPR/Cas9-based genome editing toolbox for epitope tagging of endogenous proteins in neurons. Willems J, de Jong APH, Scheefhals N, Mertens E, Catsburg LAE, Poorthuis RB, de Winter F, Verhaagen J, Meye FJ, MacGillavry HD. PLoS Biol. 2020 Apr 10;18(4):e3000665. doi: 10.1371/journal.pbio.3000665. PubMed Associated Plasmids pORANGE Cloning template vector pORANGE C9orf4-GFP KI pORANGE CACNG8-GFP KI #1 pORANGE CACNG8-GFP KI #2 pORANGE Cplx1-GFP KI More ...
Gene-based association analysis reveals involvement of LAMA5 and cell adhesion pathways in nicotine dependence in African- and European-American samples. Fan R, Cui W, Chen J, Ma Y, Yang Z, Payne TJ, Ma JZ, Li MD. Addict Biol. 2020 Apr 13:e12898. doi: 10.1111/adb.12898. PubMed
BMAL1 coordinates energy metabolism and differentiation of pluripotent stem cells. Ameneiro C, Moreira T, Fuentes-Iglesias A, Coego A, Garcia-Outeiral V, Escudero A, Torrecilla D, Mulero-Navarro S, Carvajal-Gonzalez JM, Guallar D, Fidalgo M. Life Sci Alliance. 2020 Apr 13;3(5). pii: 3/5/e201900534. doi: 10.26508/lsa.201900534. Print 2020 May. PubMed
The WW domains dictate isoform-specific regulation of YAP1 stability and pancreatic cancer cell malignancy. Guo Q, Quan M, Dong J, Bai J, Wang J, Han R, Wang W, Cai Y, Lv YQ, Chen Q, Xu H, Lyu HD, Deng L, Zhou D, Xiao X, De Langhe S, Billadeau DD, Lou Z, Zhang JS. Theranostics. 2020 Mar 15;10(10):4422-4436. doi: 10.7150/thno.42795. eCollection 2020. PubMed
Prss55 but not Prss51 is required for male fertility in micedagger. Kobayashi K, Endo T, Matsumura T, Lu Y, Yu Z, Matzuk MM, Ikawa M. Biol Reprod. 2020 Aug 4;103(2):223-234. doi: 10.1093/biolre/ioaa041. PubMed
Tollip coordinates Parkin-dependent trafficking of mitochondrial-derived vesicles. Ryan TA, Phillips EO, Collier CL, Jb Robinson A, Routledge D, Wood RE, Assar EA, Tumbarello DA. EMBO J. 2020 Jun 2;39(11):e102539. doi: 10.15252/embj.2019102539. Epub 2020 Apr 20. PubMed Associated Plasmids GFP-Tollip GFP-Tollip M240A,F241A pIRESneo2 mycBioID-Tollip pIRESneo2 mycBioID-Tollip M240A,F241A pLentiCRISPRv1 sgTollip
beta-catenin-mediated Wnt signal transduction proceeds through an endocytosis-independent mechanism. Rim EY, Kinney LK, Nusse R. Mol Biol Cell. 2020 Jun 15;31(13):1425-1436. doi: 10.1091/mbc.E20-02-0114. Epub 2020 Apr 22. PubMed
An optimized toolbox for the optogenetic control of intracellular transport. Nijenhuis W, van Grinsven MMP, Kapitein LC. J Cell Biol. 2020 Apr 6;219(4). pii: 133834. doi: 10.1083/jcb.201907149. PubMed Associated Plasmids pB80-empty pB80-FKBP-mCherry-RAB11 pB80-iLID-mCherry-RAB11 pB80-iLID-mCherry-RAB5 pB80-LAMP1-mCherry-iLID More ...
Transgenic Overexpression of the Disordered Prion Protein N1 Fragment in Mice Does Not Protect Against Neurodegenerative Diseases Due to Impaired ER Translocation. Mohammadi B, Linsenmeier L, Shafiq M, Puig B, Galliciotti G, Giudici C, Willem M, Eden T, Koch-Nolte F, Lin YH, Tatzelt J, Glatzel M, Altmeppen HC. Mol Neurobiol. 2020 Jun;57(6):2812-2829. doi: 10.1007/s12035-020-01917-2. Epub 2020 May 4. PubMed
Up-Regulation of Activating Transcription Factor 3 in Human Fibroblasts Inhibits Melanoma Cell Growth and Migration Through a Paracrine Pathway. Zu T, Wen J, Xu L, Li H, Mi J, Li H, Brakebusch C, Fisher DE, Wu X. Front Oncol. 2020 Apr 21;10:624. doi: 10.3389/fonc.2020.00624. eCollection 2020. PubMed
Characterization of agonist-dependent somatostatin receptor subtype 2 trafficking in neuroendocrine cells. Alshafie W, Pan YE, Kreienkamp HJ, Stroh T. Endocrine. 2020 Sep;69(3):655-669. doi: 10.1007/s12020-020-02329-x. Epub 2020 May 7. PubMed
Loss of Ena/VASP interferes with lamellipodium architecture, motility and integrin-dependent adhesion. Damiano-Guercio J, Kurzawa L, Mueller J, Dimchev G, Schaks M, Nemethova M, Pokrant T, Bruhmann S, Linkner J, Blanchoin L, Sixt M, Rottner K, Faix J. Elife. 2020 May 11;9. pii: 55351. doi: 10.7554/eLife.55351. PubMed
Multiplex precise base editing in cynomolgus monkeys. Zhang W, Aida T, Del Rosario RCH, Wilde JJ, Ding C, Zhang X, Baloch Z, Huang Y, Tang Y, Li D, Lu H, Zhou Y, Jiang M, Xu D, Fang Z, Zheng Z, Huang Q, Feng G, Yang S. Nat Commun. 2020 May 11;11(1):2325. doi: 10.1038/s41467-020-16173-0. PubMed
Novel role of ASH1L histone methyltransferase in anaplastic thyroid carcinoma. Xu B, Qin T, Yu J, Giordano TJ, Sartor MA, Koenig RJ. J Biol Chem. 2020 Jun 26;295(26):8834-8845. doi: 10.1074/jbc.RA120.013530. Epub 2020 May 12. PubMed
Characterization of the ZFX family of transcription factors that bind downstream of the start site of CpG island promoters. Ni W, Perez AA, Schreiner S, Nicolet CM, Farnham PJ. Nucleic Acids Res. 2020 Jun 19;48(11):5986-6000. doi: 10.1093/nar/gkaa384. PubMed
YAP-Mediated Recruitment of YY1 and EZH2 Represses Transcription of Key Cell-Cycle Regulators. Hoxha S, Shepard A, Troutman S, Diao H, Doherty JR, Janiszewska M, Witwicki RM, Pipkin ME, Ja WW, Kareta MS, Kissil JL. Cancer Res. 2020 Jun 15;80(12):2512-2522. doi: 10.1158/0008-5472.CAN-19-2415. Epub 2020 May 14. PubMed
HDAC1 inhibition ameliorates TDP-43-induced cell death in vitro and in vivo. Sanna S, Esposito S, Masala A, Sini P, Nieddu G, Galioto M, Fais M, Iaccarino C, Cestra G, Crosio C. Cell Death Dis. 2020 May 14;11(5):369. doi: 10.1038/s41419-020-2580-3. PubMed
Pathological role of excessive DNA as a trigger of keratinocyte proliferation in psoriasis. Luo Y, Hara T, Kawashima A, Ishido Y, Suzuki S, Ishii N, Kambara T, Suzuki K. Clin Exp Immunol. 2020 May 16. doi: 10.1111/cei.13455. PubMed
GABRG2 Deletion Linked to Genetic Epilepsy with Febrile Seizures Plus Affects the Expression of GABAA Receptor Subunits and Other Genes at Different Temperatures. Li X, Guo S, Liu K, Zhang C, Chang H, Yang W, Rong S, Hu Q, Cui J, Wang F, Sun T. Neuroscience. 2020 Jul 1;438:116-136. doi: 10.1016/j.neuroscience.2020.04.049. Epub 2020 May 8. PubMed
Fam20C regulates protein secretion by Cab45 phosphorylation. Hecht TK, Blank B, Steger M, Lopez V, Beck G, Ramazanov B, Mann M, Tagliabracci V, von Blume J. J Cell Biol. 2020 Jun 1;219(6). pii: 151783. doi: 10.1083/jcb.201910089. PubMed
Generation of Transgenic Cloned Buffalo Embryos Harboring the EGFP Gene in the Y Chromosome Using CRISPR/Cas9-Mediated Targeted Integration. Zhao X, Nie J, Tang Y, He W, Xiao K, Pang C, Liang X, Lu Y, Zhang M. Front Vet Sci. 2020 Apr 23;7:199. doi: 10.3389/fvets.2020.00199. eCollection 2020. PubMed
BIX-01294 enhanced chemotherapy effect in gastric cancer by inducing GSDME-mediated pyroptosis. Deng BB, Jiao BP, Liu YJ, Li YR, Wang GJ. Cell Biol Int. 2020 Sep;44(9):1890-1899. doi: 10.1002/cbin.11395. Epub 2020 Jun 8. PubMed
Consequences of Lmna Exon 4 Mutations in Myoblast Function. Gomez-Dominguez D, Epifano C, Miguel F, Castano AG, Vilaplana-Marti B, Martin A, Amarilla-Quintana S, Bertrand AT, Bonne G, Ramon-Azcon J, Rodriguez-Milla MA, Perez de Castro I. Cells. 2020 May 21;9(5). pii: cells9051286. doi: 10.3390/cells9051286. PubMed
Constructing Auxin-Inducible Degron Mutants Using an All-in-One Vector. Yesbolatova A, Saito Y, Kanemaki MT. Pharmaceuticals (Basel). 2020 May 23;13(5). pii: ph13050103. doi: 10.3390/ph13050103. PubMed Associated Plasmids pAID5.1-N pAID5.1-C pAID5.2-N pAID5.2-C pAID5.3-N More ...
Regulation of poly(a)-specific ribonuclease activity by reversible lysine acetylation. Dejene EA, Li Y, Showkatian Z, Ling H, Seto E. J Biol Chem. 2020 Jul 24;295(30):10255-10270. doi: 10.1074/jbc.RA120.012552. Epub 2020 May 26. PubMed
Detection of Deleterious On-Target Effects after HDR-Mediated CRISPR Editing. Weisheit I, Kroeger JA, Malik R, Klimmt J, Crusius D, Dannert A, Dichgans M, Paquet D. Cell Rep. 2020 May 26;31(8):107689. doi: 10.1016/j.celrep.2020.107689. PubMed
Noncoding Y RNAs regulate the levels, subcellular distribution and protein interactions of their Ro60 autoantigen partner. Leng Y, Sim S, Magidson V, Wolin SL. Nucleic Acids Res. 2020 Jul 9;48(12):6919-6930. doi: 10.1093/nar/gkaa414. PubMed
The accessory subunit of human DNA polymerase gamma is required for mitochondrial DNA maintenance and is able to stabilize the catalytic subunit. Do Y, Matsuda S, Inatomi T, Nakada K, Yasukawa T, Kang D. Mitochondrion. 2020 Jul;53:133-139. doi: 10.1016/j.mito.2020.05.008. Epub 2020 May 26. PubMed
A RIG-I-like receptor directs antiviral responses to a bunyavirus and is antagonized by virus-induced blockade of TRIM25-mediated ubiquitination. Min YQ, Ning YJ, Wang H, Deng F. J Biol Chem. 2020 Jul 10;295(28):9691-9711. doi: 10.1074/jbc.RA120.013973. Epub 2020 May 29. PubMed
TBC1D24 regulates recycling of clathrin-independent cargo proteins mediated by tubular recycling endosomes. Kim Nguyen NT, Ohbayashi N, Kanaho Y, Funakoshi Y. Biochem Biophys Res Commun. 2020 Jul 12;528(1):220-226. doi: 10.1016/j.bbrc.2020.05.007. Epub 2020 May 29. PubMed
Regulatory sharing between estrogen receptor alpha bound enhancers. Carleton JB, Ginley-Hidinger M, Berrett KC, Layer RM, Quinlan AR, Gertz J. Nucleic Acids Res. 2020 Jul 9;48(12):6597-6610. doi: 10.1093/nar/gkaa454. PubMed
The polycomb group protein PCGF6 mediates germline gene silencing by recruiting histone-modifying proteins to target gene promoters. Liu M, Zhu Y, Xing F, Liu S, Xia Y, Jiang Q, Qin J. J Biol Chem. 2020 Jul 10;295(28):9712-9724. doi: 10.1074/jbc.RA119.012121. Epub 2020 Jun 1. PubMed
Allele-Specific Prevention of Nonsense-Mediated Decay in Cystic Fibrosis Using Homology-Independent Genome Editing. Erwood S, Laselva O, Bily TMI, Brewer RA, Rutherford AH, Bear CE, Ivakine EA. Mol Ther Methods Clin Dev. 2020 May 12;17:1118-1128. doi: 10.1016/j.omtm.2020.05.002. eCollection 2020 Jun 12. PubMed
Inhibition of ROCK2 alleviates renal fibrosis and the metabolic disorders in the proximal tubular epithelial cells. You R, Zhou W, Li Y, Zhang Y, Huang S, Jia Z, Zhang A. Clin Sci (Lond). 2020 Jun 26;134(12):1357-1376. doi: 10.1042/CS20200030. PubMed
Efficient CRISPR/Cas9-mediated gene editing in Guangdong small-ear spotted pig cells using an optimized electrotransfection method. Wei YY, Zhan QM, Zhu XX, Yan AF, Feng J, Liu L, Li JH, Tang DS. Biotechnol Lett. 2020 Jun 3. pii: 10.1007/s10529-020-02930-0. doi: 10.1007/s10529-020-02930-0. PubMed
Hippo-YAP signaling controls lineage differentiation of mouse embryonic stem cells through modulating the formation of super-enhancers. Sun X, Ren Z, Cun Y, Zhao C, Huang X, Zhou J, Hu R, Su X, Ji L, Li P, Mak KLK, Gao F, Yang Y, Xu H, Ding J, Cao N, Li S, Zhang W, Lan P, Sun H, Wang J, Yuan P. Nucleic Acids Res. 2020 Jul 27;48(13):7182-7196. doi: 10.1093/nar/gkaa482. PubMed
Immunoglobulin Class Switch Recombination Is Initiated by Rare Cytosine Deamination Events at Switch Regions. Kim A, Han L, Yu K. Mol Cell Biol. 2020 Jul 29;40(16). pii: MCB.00125-20. doi: 10.1128/MCB.00125-20. Print 2020 Jul 29. PubMed
Synergistic gene editing in human iPS cells via cell cycle and DNA repair modulation. Maurissen TL, Woltjen K. Nat Commun. 2020 Jun 8;11(1):2876. doi: 10.1038/s41467-020-16643-5. PubMed
Basement membrane remodelling regulates mouse embryogenesis. Kyprianou C, Christodoulou N, Hamilton RS, Nahaboo W, Boomgaard DS, Amadei G, Migeotte I, Zernicka-Goetz M. Nature. 2020 Jun;582(7811):253-258. doi: 10.1038/s41586-020-2264-2. Epub 2020 May 6. PubMed
Modeling and Rescue of RP2 Retinitis Pigmentosa Using iPSC-Derived Retinal Organoids. Lane A, Jovanovic K, Shortall C, Ottaviani D, Panes AB, Schwarz N, Guarascio R, Hayes MJ, Palfi A, Chadderton N, Farrar GJ, Hardcastle AJ, Cheetham ME. Stem Cell Reports. 2020 Jul 14;15(1):67-79. doi: 10.1016/j.stemcr.2020.05.007. Epub 2020 Jun 11. PubMed
Kir2.1 interactome mapping uncovers PKP4 as a modulator of the Kir2.1-regulated inward rectifier potassium currents. Park SS, Ponce-Balbuena D, Kuick R, Guerrero-Serna G, Yoon J, Mellacheruvu D, Conlon KP, Basrur V, Nesvizhskii AI, Jalife J, Rual JF. Mol Cell Proteomics. 2020 Jun 15. pii: RA120.002071. doi: 10.1074/mcp.RA120.002071. PubMed
BAP1 is a haploinsufficient tumor suppressor linking chronic pancreatitis to pancreatic cancer in mice. Perkail S, Andricovich J, Kai Y, Tzatsos A. Nat Commun. 2020 Jun 15;11(1):3018. doi: 10.1038/s41467-020-16589-8. PubMed
Intragenic recruitment of NF-kappaB drives splicing modifications upon activation by the oncogene Tax of HTLV-1. Ameur LB, Marie P, Thenoz M, Giraud G, Combe E, Claude JB, Lemaire S, Fontrodona N, Polveche H, Bastien M, Gessain A, Wattel E, Bourgeois CF, Auboeuf D, Mortreux F. Nat Commun. 2020 Jun 16;11(1):3045. doi: 10.1038/s41467-020-16853-x. PubMed
PARP1 Is Required for ATM-Mediated p53 Activation and p53-Mediated Gene Expression after Ionizing Radiation. Gajewski S, Hartwig A. Chem Res Toxicol. 2020 Jul 20;33(7):1933-1940. doi: 10.1021/acs.chemrestox.0c00130. Epub 2020 Jul 7. PubMed
LUZP1, a novel regulator of primary cilia and the actin cytoskeleton, is a contributing factor in Townes-Brocks Syndrome. Bozal-Basterra L, Gonzalez-Santamarta M, Muratore V, Bermejo-Arteagabeitia A, Da Fonseca C, Barroso-Gomila O, Azkargorta M, Iloro I, Pampliega O, Andrade R, Martin-Martin N, Branon TC, Ting AY, Rodriguez JA, Carracedo A, Elortza F, Sutherland JD, Barrio R. Elife. 2020 Jun 18;9. pii: 55957. doi: 10.7554/eLife.55957. PubMed
Inactivation of REV7 enhances chemosensitivity and overcomes acquired chemoresistance in testicular germ cell tumors. Sakurai Y, Ichinoe M, Yoshida K, Nakazato Y, Saito S, Satoh M, Nakada N, Sanoyama I, Umezawa A, Numata Y, Shi-Xu J, Ichihara M, Takahashi M, Murakumo Y. Cancer Lett. 2020 Oct 1;489:100-110. doi: 10.1016/j.canlet.2020.06.001. Epub 2020 Jun 15. PubMed
BRPF3-HUWE1-mediated regulation of MYST2 is required for differentiation and cell-cycle progression in embryonic stem cells. Cho HI, Kim MS, Lee J, Yoo BC, Kim KH, Choe KM, Jang YK. Cell Death Differ. 2020 Jun 18. pii: 10.1038/s41418-020-0577-1. doi: 10.1038/s41418-020-0577-1. PubMed
Genome-wide analysis in the mouse embryo reveals the importance of DNA methylation for transcription integrity. Dahlet T, Argueso Lleida A, Al Adhami H, Dumas M, Bender A, Ngondo RP, Tanguy M, Vallet J, Auclair G, Bardet AF, Weber M. Nat Commun. 2020 Jun 19;11(1):3153. doi: 10.1038/s41467-020-16919-w. PubMed
CRISPR/Cas9-mediated genome-edited mice reveal 10 testis-enriched genes are dispensable for male fecundity. Park S, Shimada K, Fujihara Y, Xu Z, Shimada K, Larasati T, Pratiwi P, Matzuk RM, Devlin DJ, Yu Z, Garcia TX, Matzuk MM, Ikawa M. Biol Reprod. 2020 Aug 4;103(2):195-204. doi: 10.1093/biolre/ioaa084. PubMed
Proteome-wide Interrogation of Small GTPases Regulated by N(6)-Methyladenosine Modulators. Yang YY, Yu K, Li L, Huang M, Wang Y. Anal Chem. 2020 Jul 21;92(14):10145-10152. doi: 10.1021/acs.analchem.0c02203. Epub 2020 Jul 7. PubMed
Enforced Activation of Enhancer RNAs In Situ through the dCas9 Synergistic Activation Mediator System. Liao Z, Lee JH, Krakowiak J, Wang R, Li W. J Vis Exp. 2020 Jun 5;(160). doi: 10.3791/61460. PubMed
mTOR and S6K1 drive polycystic kidney by the control of Afadin-dependent oriented cell division. Bonucci M, Kuperwasser N, Barbe S, Koka V, de Villeneuve D, Zhang C, Srivastava N, Jia X, Stokes MP, Bienaime F, Verkarre V, Lopez JB, Jaulin F, Pontoglio M, Terzi F, Delaval B, Piel M, Pende M. Nat Commun. 2020 Jun 24;11(1):3200. doi: 10.1038/s41467-020-16978-z. PubMed
RBM45 associates with nuclear stress bodies and forms nuclear inclusions during chronic cellular stress and in neurodegenerative diseases. Collins M, Li Y, Bowser R. Acta Neuropathol Commun. 2020 Jun 26;8(1):91. doi: 10.1186/s40478-020-00965-y. PubMed
CRISPR/Cas9-based genome editing in mice uncovers 13 testis- or epididymis-enriched genes individually dispensable for male reproductiondagger. Sun J, Lu Y, Nozawa K, Xu Z, Morohoshi A, Castaneda JM, Noda T, Miyata H, Abbasi F, Shawki HH, Takahashi S, Devlin DJ, Yu Z, Matzuk RM, Garcia TX, Matzuk MM, Ikawa M. Biol Reprod. 2020 Aug 4;103(2):183-194. doi: 10.1093/biolre/ioaa083. PubMed
Recognition of Semaphorin Proteins by P. sordellii Lethal Toxin Reveals Principles of Receptor Specificity in Clostridial Toxins. Lee H, Beilhartz GL, Kucharska I, Raman S, Cui H, Lam MHY, Liang H, Rubinstein JL, Schramek D, Julien JP, Melnyk RA, Taipale M. Cell. 2020 Jul 23;182(2):345-356.e16. doi: 10.1016/j.cell.2020.06.005. Epub 2020 Jun 25. PubMed
Spermine synthase and MYC cooperate to maintain colorectal cancer cell survival by repressing Bim expression. Guo Y, Ye Q, Deng P, Cao Y, He D, Zhou Z, Wang C, Zaytseva YY, Schwartz CE, Lee EY, Mark Evers B, Morris AJ, Liu S, She QB. Nat Commun. 2020 Jun 26;11(1):3243. doi: 10.1038/s41467-020-17067-x. PubMed
Evaluation of the CRISPR/Cas9 Genetic Constructs in Efficient Disruption of Porcine Genes for Xenotransplantation Purposes Along with an Assessment of the Off-Target Mutation Formation. Ryczek N, Hryhorowicz M, Lipinski D, Zeyland J, Slomski R. Genes (Basel). 2020 Jun 26;11(6). pii: genes11060713. doi: 10.3390/genes11060713. PubMed
Increased expression and retention of the secretory chaperone proSAAS following cell stress. Shakya M, Yildirim T, Lindberg I. Cell Stress Chaperones. 2020 Jul 20. pii: 10.1007/s12192-020-01128-7. doi: 10.1007/s12192-020-01128-7. PubMed
Atrx Deletion in Neurons Leads to Sexually Dimorphic Dysregulation of miR-137 and Spatial Learning and Memory Deficits. Tamming RJ, Dumeaux V, Jiang Y, Shafiq S, Langlois L, Ellegood J, Qiu LR, Lerch JP, Berube NG. Cell Rep. 2020 Jun 30;31(13):107838. doi: 10.1016/j.celrep.2020.107838. PubMed
Loss of TET2 Affects Proliferation and Drug Sensitivity through Altered Dynamics of Cell-State Transitions. Morinishi L, Kochanowski K, Levine RL, Wu LF, Altschuler SJ. Cell Syst. 2020 Jul 22;11(1):86-94.e5. doi: 10.1016/j.cels.2020.06.003. Epub 2020 Jul 2. PubMed
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A novel distal convoluted tubule-specific Cre-recombinase driven by the NaCl cotransporter gene. Cornelius RJ, Sharma A, Su XT, Guo JJ, McMahon JA, Ellison DH, McMahon AP, McCormick JA. Am J Physiol Renal Physiol. 2020 Sep 1;319(3):F423-F435. doi: 10.1152/ajprenal.00101.2020. Epub 2020 Jul 13. PubMed
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Herpes Simplex Virus Type 2 Counteracts Neurite Outgrowth Repulsion During Infection In A Nerve Growth Factor-Dependent Manner. Kropp KA, Lopez-Munoz AD, Ritter B, Martin R, Rastrojo A, Srivaratharajan S, Dohner K, Dhingra A, Czechowicz JS, Nagel CH, Sodeik B, Alcami A, Viejo-Borbolla A. J Virol. 2020 Jul 15. pii: JVI.01370-20. doi: 10.1128/JVI.01370-20. PubMed
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Derivation of human pluripotent stem cell line via CRISPR/Cas9 mediated deletion of exon 3 LAMA2 gene (DMBi001-A-1). Jelinkova S, Martyniak A, Dulak J, Stepniewski J. Stem Cell Res. 2021 Oct;56:102529. doi: 10.1016/j.scr.2021.102529. Epub 2021 Sep 2. PubMed
EGFR-RAS-MAPK signaling is confined to the plasma membrane and associated endorecycling protrusions. Surve S, Watkins SC, Sorkin A. J Cell Biol. 2021 Nov 1;220(11):e202107103. doi: 10.1083/jcb.202107103. Epub 2021 Sep 13. PubMed
A natural variant in ANP32B impairs influenza virus replication in human cells. Staller E, Sheppard CM, Baillon L, Frise R, Peacock TP, Sancho-Shimizu V, Barclay WS. J Gen Virol. 2021 Sep;102(9). doi: 10.1099/jgv.0.001664. PubMed
STAT3 contributes to cisplatin resistance, modulating EMT markers, and the mTOR signaling in lung adenocarcinoma. Morelli AP, Tortelli TC Jr, Mancini MCS, Pavan ICB, Silva LGS, Severino MB, Granato DC, Pestana NF, Ponte LGS, Peruca GF, Pauletti BA, Dos Santos DFG Jr, de Moura LP, Bezerra RMN, Leme AFP, Chammas R, Simabuco FM. Neoplasia. 2021 Sep 17;23(10):1048-1058. doi: 10.1016/j.neo.2021.08.003. PubMed
Generation of the Y-chromosome linked red fluorescent protein transgenic mouse model and sexing at the preimplantation stage. Hirata W, Tomoda T, Yuri S, Isotani A. Exp Anim. 2022 Feb 9;71(1):82-89. doi: 10.1538/expanim.21-0119. Epub 2021 Sep 20. PubMed
CRISPR/Cas9 Ablation of Integrated HIV-1 Accumulates Proviral DNA Circles with Reformed Long Terminal Repeats. Lai M, Maori E, Quaranta P, Matteoli G, Maggi F, Sgarbanti M, Crucitta S, Pacini S, Turriziani O, Antonelli G, Heeney JL, Freer G, Pistello M. J Virol. 2021 Nov 9;95(23):e0135821. doi: 10.1128/JVI.01358-21. Epub 2021 Sep 22. PubMed
Modeling of dilated cardiomyopathy by establishment of isogenic human iPSC lines carrying phospholamban C25T (R9C) mutation (UPITTi002-A-1) using CRISPR/Cas9 editing. Barndt RJ, Ma N, Tang Y, Haugh MP, Alamri LS, Chan SY, Wu H. Stem Cell Res. 2021 Oct;56:102544. doi: 10.1016/j.scr.2021.102544. Epub 2021 Sep 20. PubMed
Approaches to Study Native Chromatin-Modifying Complex Activities and Functions. Galloy M, Lachance C, Cheng X, Distefano-Gagne F, Cote J, Fradet-Turcotte A. Front Cell Dev Biol. 2021 Sep 16;9:729338. doi: 10.3389/fcell.2021.729338. eCollection 2021. PubMed
NBS1 I171V variant underlies individual differences in chromosomal radiosensitivity within human populations. Tomioka K, Miyamoto T, Akutsu SN, Yanagihara H, Fujita K, Royba E, Tauchi H, Yamamoto T, Koh I, Hirata E, Kudo Y, Kobayashi M, Okada S, Matsuura S. Sci Rep. 2021 Oct 4;11(1):19661. doi: 10.1038/s41598-021-98673-7. PubMed
NEDD8-activating enzyme inhibition induces cell cycle arrest and anaphase catastrophe in malignant T-cells. Kittai AS, Danilova OV, Lam V, Liu T, Bruss N, Best S, Fan G, Danilov AV. Oncotarget. 2021 Sep 28;12(20):2068-2074. doi: 10.18632/oncotarget.28063. eCollection 2021 Sep 28. PubMed
Conditional CRISPR-mediated deletion of Lyn kinase enhances differentiation and function of iPSC-derived megakaryocytes. Moroi AJ, Newman PJ. J Thromb Haemost. 2022 Jan;20(1):182-195. doi: 10.1111/jth.15546. Epub 2021 Oct 17. PubMed
R-2HG downregulates ERalpha to inhibit cholangiocarcinoma via the FTO/m6A-methylated ERalpha/miR16-5p/YAP1 signal pathway. Gao Y, Ouyang X, Zuo L, Xiao Y, Sun Y, Chang C, Qin X, Yeh S. Mol Ther Oncolytics. 2021 Jul 10;23:65-81. doi: 10.1016/j.omto.2021.06.017. eCollection 2021 Dec 17. PubMed
IRAK1-dependent Regnase-1-14-3-3 complex formation controls Regnase-1-mediated mRNA decay. Akaki K, Ogata K, Yamauchi Y, Iwai N, Tse KM, Hia F, Mochizuki A, Ishihama Y, Mino T, Takeuchi O. Elife. 2021 Oct 12;10. pii: 71966. doi: 10.7554/eLife.71966. PubMed
Plakophilin-2 truncating variants impair cardiac contractility by disrupting sarcomere stability and organization. Zhang K, Cloonan PE, Sundaram S, Liu F, Das SL, Ewoldt JK, Bays JL, Tomp S, Toepfer CN, Marsiglia JDC, Gorham J, Reichart D, Eyckmans J, Seidman JG, Seidman CE, Chen CS. Sci Adv. 2021 Oct 15;7(42):eabh3995. doi: 10.1126/sciadv.abh3995. Epub 2021 Oct 15. PubMed
Allele-specific gene editing to rescue dominant CRX-associated LCA7 phenotypes in a retinal organoid model. Chirco KR, Chew S, Moore AT, Duncan JL, Lamba DA. Stem Cell Reports. 2021 Nov 9;16(11):2690-2702. doi: 10.1016/j.stemcr.2021.09.007. Epub 2021 Oct 14. PubMed
CellFIE: CRISPR- and Cell Fusion-based Two-hybrid Interaction Mapping of Endogenous Proteins. Secker C, Kostova S, Niederlechner H, Beetz S, Wendland I, Liebich MJ, Polzer O, Groh M, Schnoegl S, Trepte P, Wanker EE. J Mol Biol. 2021 Dec 3;433(24):167305. doi: 10.1016/j.jmb.2021.167305. Epub 2021 Oct 14. PubMed
Redundant roles of EGFR ligands in the ERK activation waves during collective cell migration. Lin S, Hirayama D, Maryu G, Matsuda K, Hino N, Deguchi E, Aoki K, Iwamoto R, Terai K, Matsuda M. Life Sci Alliance. 2021 Oct 19;5(1). pii: 5/1/e202101206. doi: 10.26508/lsa.202101206. Print 2022 Jan. PubMed Associated Plasmids pX459-dNrg1 pX459-dEreg pX459-dTgfa pX459-dHbegf pX459-dEgf More ...
Overexpression of smad7 inhibits the TGF-beta/Smad signaling pathway and EMT in NPHP1-defective MDCK cells. Wu X, Wang H, Chen H, Lin H, Li M, Yue Z, Sun L. Biochem Biophys Res Commun. 2021 Dec 10;582:57-63. doi: 10.1016/j.bbrc.2021.10.037. Epub 2021 Oct 18. PubMed
Co-occurrence of BAP1 and SF3B1 mutations in uveal melanoma induces cellular senescence. Yu L, Zhou D, Zhang G, Ren Z, Luo X, Liu P, Plouffe SW, Meng Z, Moroishi T, Li Y, Zhang Y, Brown JH, Liu S, Guan KL. Mol Oncol. 2022 Feb;16(3):607-629. doi: 10.1002/1878-0261.13128. Epub 2021 Nov 12. PubMed
Two redundant ubiquitin-dependent pathways of BRCA1 localization to DNA damage sites. Sherker A, Chaudhary N, Adam S, Heijink AM, Noordermeer SM, Fradet-Turcotte A, Durocher D. EMBO Rep. 2021 Dec 6;22(12):e53679. doi: 10.15252/embr.202153679. Epub 2021 Nov 2. PubMed
Human iPS cell derived RPE strips for secure delivery of graft cells at a target place with minimal surgical invasion. Nishida M, Tanaka Y, Tanaka Y, Amaya S, Tanaka N, Uyama H, Masuda T, Onishi A, Sho J, Yokota S, Takahashi M, Mandai M. Sci Rep. 2021 Nov 2;11(1):21421. doi: 10.1038/s41598-021-00703-x. PubMed
Sirtuin 7 super-enhancer drives epigenomic reprogramming in hepatocarcinogenesis. Wu F, Xu L, Tu Y, Cheung OK, Szeto LL, Mok MT, Yang W, Kang W, Cao Q, Lai PB, Chan SL, Tan P, Sung JJ, Yip KY, Cheng AS, To KF. Cancer Lett. 2022 Jan 28;525:115-130. doi: 10.1016/j.canlet.2021.10.039. Epub 2021 Nov 1. PubMed
Flow cytometry-based quantification of targeted knock-in events in human cell lines using a GPI-anchor biosynthesis gene PIGP. Rahman ML, Hyodo T, Hasan MN, Mihara Y, Karnan S, Ota A, Tsuzuki S, Hosokawa Y, Konishi H. Biosci Rep. 2021 Dec 22;41(12). pii: 230169. doi: 10.1042/BSR20212231. PubMed
The ethanol extract of Garcinia subelliptica Merr. induces autophagy. Kim KH, Lee JY, Li WY, Lee S, Jeong HS, Choi JY, Joo M. BMC Complement Med Ther. 2021 Nov 10;21(1):280. doi: 10.1186/s12906-021-03454-4. PubMed
CD109 expression in tumor cells and stroma correlates with progression and prognosis in pancreatic cancer. Adachi K, Sakurai Y, Ichinoe M, Tadehara M, Tamaki A, Kesen Y, Kato T, Mii S, Enomoto A, Takahashi M, Koizumi W, Murakumo Y. Virchows Arch. 2022 Apr;480(4):819-829. doi: 10.1007/s00428-021-03230-2. Epub 2021 Nov 11. PubMed
alpha-Galactosidase a Deficiency in Fabry Disease Leads to Extensive Dysregulated Cellular Signaling Pathways in Human Podocytes. Jehn U, Bayraktar S, Pollmann S, Van Marck V, Weide T, Pavenstadt H, Brand E, Lenders M. Int J Mol Sci. 2021 Oct 20;22(21). pii: ijms222111339. doi: 10.3390/ijms222111339. PubMed
The Fibrotic Effects of TMAO on Human Renal Fibroblasts Is Mediated by NLRP3, Caspase-1 and the PERK/Akt/mTOR Pathway. Kapetanaki S, Kumawat AK, Persson K, Demirel I. Int J Mol Sci. 2021 Nov 1;22(21). pii: ijms222111864. doi: 10.3390/ijms222111864. PubMed
The phosphoinositide coincidence detector Phafin2 promotes macropinocytosis by coordinating actin organisation at forming macropinosomes. Schink KO, Tan KW, Spangenberg H, Martorana D, Sneeggen M, Stevenin V, Enninga J, Campsteijn C, Raiborg C, Stenmark H. Nat Commun. 2021 Nov 12;12(1):6577. doi: 10.1038/s41467-021-26775-x. PubMed
HLA-G gene editing in tumor cell lines as a novel alternative in cancer immunotherapy. Palma MB, Tronik-Le Roux D, Amin G, Castaneda S, Mobbs AM, Scarafia MA, La Greca A, Daouya M, Poras I, Inda AM, Moro LN, Carosella ED, Garcia MN, Miriuka SG. Sci Rep. 2021 Nov 12;11(1):22158. doi: 10.1038/s41598-021-01572-0. PubMed Associated Plasmids pSpCas9-Puro HLAG-2A-sgRNA pSpCas9-Puro HLAG-2B-sgRNA
Serine palmitoyltransferase assembles at ER-mitochondria contact sites. Aaltonen MJ, Alecu I, Konig T, Bennett SA, Shoubridge EA. Life Sci Alliance. 2021 Nov 16;5(2). pii: 5/2/e202101278. doi: 10.26508/lsa.202101278. Print 2022 Feb. PubMed
Efficient mutagenesis targeting the IFNAR1 gene in mice using a combination of Cas9 protein and dual gRNAs. Liu Z, Chen Z, Di J, Wang Z, Zhang Y, Li J, An L, Presicce GA, Liu L, Du F. Am J Transl Res. 2021 Oct 15;13(10):12094-12106. eCollection 2021. PubMed
Targeting the spliceosome through RBM39 degradation results in exceptional responses in high-risk neuroblastoma models. Singh S, Quarni W, Goralski M, Wan S, Jin H, Van de Velde LA, Fang J, Wu Q, Abu-Zaid A, Wang T, Singh R, Craft D, Fan Y, Confer T, Johnson M, Akers WJ, Wang R, Murray PJ, Thomas PG, Nijhawan D, Davidoff AM, Yang J. Sci Adv. 2021 Nov 19;7(47):eabj5405. doi: 10.1126/sciadv.abj5405. Epub 2021 Nov 17. PubMed
Identification of proximal SUMO-dependent interactors using SUMO-ID. Barroso-Gomila O, Trulsson F, Muratore V, Canosa I, Merino-Cacho L, Cortazar AR, Perez C, Azkargorta M, Iloro I, Carracedo A, Aransay AM, Elortza F, Mayor U, Vertegaal ACO, Barrio R, Sutherland JD. Nat Commun. 2021 Nov 18;12(1):6671. doi: 10.1038/s41467-021-26807-6. PubMed Associated Plasmids TRIPZ-CTID195-GSQ-SUMO1nc-PURO TRIPZ-CTID195-GSQ-UBnc-PURO Lenti-EFS-NTID194-GSQ-PMLivaWT-P2A-BLAST Lenti-EFS-NTID194-GSQ-PMLiva3MAS-P2A-BLAST Lenti-EFS-FLTID-GSQ-PMLivaWT-P2A-BLAST More ...
Type I interferon activates MHC class I-dressed CD11b(+) conventional dendritic cells to promote protective anti-tumor CD8(+) T cell immunity. Duong E, Fessenden TB, Lutz E, Dinter T, Yim L, Blatt S, Bhutkar A, Wittrup KD, Spranger S. Immunity. 2022 Feb 8;55(2):308-323.e9. doi: 10.1016/j.immuni.2021.10.020. Epub 2021 Nov 19. PubMed
TCR-independent Activation in Presence of a Src-family Kinase Inhibitor Improves CAR-T Cell Product Attributes. Lamture G, Baer A, Fischer JW, Colon-Moran W, Bhattarai N. J Immunother. 2022 Apr 1;45(3):139-149. doi: 10.1097/CJI.0000000000000402. PubMed
The ARF GAPs ELMOD1 and ELMOD3 act at the Golgi and cilia to regulate ciliogenesis and ciliary protein traffic. Turn RE, Hu Y, Dewees SI, Devi N, East MP, Hardin KR, Khatib T, Linnert J, Wolfrum U, Lim MJ, Casanova JE, Caspary T, Kahn RA. Mol Biol Cell. 2022 Feb 1;33(2):ar13. doi: 10.1091/mbc.E21-09-0443. Epub 2021 Nov 24. PubMed
Intratumoral co-injection of the poly I:C-derivative BO-112 and a STING agonist synergize to achieve local and distant anti-tumor efficacy. Alvarez M, Molina C, De Andrea CE, Fernandez-Sendin M, Villalba M, Gonzalez-Gomariz J, Ochoa MC, Teijeira A, Glez-Vaz J, Aranda F, Sanmamed MF, Rodriguez-Ruiz ME, Fan X, Shen WH, Berraondo P, Quintero M, Melero I. J Immunother Cancer. 2021 Nov;9(11). pii: jitc-2021-002953. doi: 10.1136/jitc-2021-002953. PubMed
A CRISPR Activation Screen Identifies an Atypical Rho GTPase That Enhances Zika Viral Entry. Luu AP, Yao Z, Ramachandran S, Azzopardi SA, Miles LA, Schneider WM, Hoffmann HH, Bozzacco L, Garcia G Jr, Gong D, Damoiseaux R, Tang H, Morizono K, Rudin CM, Sun R, Arumugaswami V, Poirier JT, MacDonald MR, Rice CM, Li MMH. Viruses. 2021 Oct 20;13(11). pii: v13112113. doi: 10.3390/v13112113. PubMed
Assessing genome-wide dynamic changes in enhancer activity during early mESC differentiation by FAIRE-STARR-seq. Glaser LV, Steiger M, Fuchs A, van Bommel A, Einfeldt E, Chung HR, Vingron M, Meijsing SH. Nucleic Acids Res. 2021 Dec 2;49(21):12178-12195. doi: 10.1093/nar/gkab1100. PubMed
MCPH1 inhibits Condensin II during interphase by regulating its SMC2-Kleisin interface. Houlard M, Cutts EE, Shamim MS, Godwin J, Weisz D, Presser Aiden A, Lieberman Aiden E, Schermelleh L, Vannini A, Nasmyth K. Elife. 2021 Dec 1;10. pii: 73348. doi: 10.7554/eLife.73348. PubMed
Tumor evolution selectively inactivates the core microRNA machinery for immune evasion. Song TY, Long M, Zhao HX, Zou MW, Fan HJ, Liu Y, Geng CL, Song MF, Liu YF, Chen JY, Yang YL, Zhou WR, Huang DW, Peng B, Peng ZG, Cang Y. Nat Commun. 2021 Dec 1;12(1):7003. doi: 10.1038/s41467-021-27331-3. PubMed
SPEN is required for Xist upregulation during initiation of X chromosome inactivation. Robert-Finestra T, Tan BF, Mira-Bontenbal H, Timmers E, Gontan C, Merzouk S, Giaimo BD, Dossin F, van IJcken WFJ, Martens JWM, Borggrefe T, Heard E, Gribnau J. Nat Commun. 2021 Dec 1;12(1):7000. doi: 10.1038/s41467-021-27294-5. PubMed
Serine ADP-ribosylation marks nucleosomes for ALC1-dependent chromatin remodeling. Mohapatra J, Tashiro K, Beckner RL, Sierra J, Kilgore JA, Williams NS, Liszczak G. Elife. 2021 Dec 7;10. pii: 71502. doi: 10.7554/eLife.71502. PubMed
Soluble PD-L1 works as a decoy in lung cancer immunotherapy via alternative polyadenylation. Sagawa R, Sakata S, Gong B, Seto Y, Takemoto A, Takagi S, Ninomiya H, Yanagitani N, Nakao M, Mun M, Uchibori K, Nishio M, Miyazaki Y, Shiraishi Y, Ogawa S, Kataoka K, Fujita N, Takeuchi K, Katayama R. JCI Insight. 2022 Jan 11;7(1). pii: 153323. doi: 10.1172/jci.insight.153323. PubMed
TAOK2 is an ER-localized kinase that catalyzes the dynamic tethering of ER to microtubules. Nourbakhsh K, Ferreccio AA, Bernard MJ, Yadav S. Dev Cell. 2021 Dec 20;56(24):3321-3333.e5. doi: 10.1016/j.devcel.2021.11.015. Epub 2021 Dec 7. PubMed
Cytoplasmic dynein-1 cargo diversity is mediated by the combinatorial assembly of FTS-Hook-FHIP complexes. Christensen JR, Kendrick AA, Truong JB, Aguilar-Maldonado A, Adani V, Dzieciatkowska M, Reck-Peterson SL. Elife. 2021 Dec 9;10. pii: 74538. doi: 10.7554/eLife.74538. PubMed
Publicly Available hiPSC Lines with Extreme Polygenic Risk Scores for Modeling Schizophrenia. Dobrindt K, Zhang H, Das D, Abdollahi S, Prorok T, Ghosh S, Weintraub S, Genovese G, Powell SK, Lund A, Akbarian S, Eggan K, McCarroll S, Duan J, Avramopoulos D, Brennand KJ. Complex Psychiatry. 2021 Feb;6(3-4):68-82. doi: 10.1159/000512716. Epub 2020 Nov 2. PubMed
Integrin alpha6beta4 requires plectin and vimentin for adhesion complex distribution and invasive growth. Qi L, Knifley T, Chen M, O'Connor KL. J Cell Sci. 2022 Jan 15;135(2). pii: 273711. doi: 10.1242/jcs.258471. Epub 2022 Jan 28. PubMed
Activation of SGK1.1 Upregulates the M-current in the Presence of Epilepsy Mutations. Martin-Batista E, Manville RW, Rivero-Perez B, Bartolome-Martin D, Alvarez de la Rosa D, Abbott GW, Giraldez T. Front Mol Neurosci. 2021 Nov 26;14:798261. doi: 10.3389/fnmol.2021.798261. eCollection 2021. PubMed
Loss of Integrin-linked kinase sensitizes breast cancer to SRC inhibitors. Beetham H, Griffith BGC, Murina O, Loftus AE, Parry DA, Temps C, Culley J, Muir M, Unciti-Broceta A, Sims AH, Byron A, Brunton VG. Cancer Res. 2021 Dec 17. pii: 0008-5472.CAN-21-0373. doi: 10.1158/0008-5472.CAN-21-0373. PubMed Associated Plasmids PX459v2-ILK-gRNA 1-exon 1 PX459v2-ILK-gRNA 2-exon 8 eSpCas9(1.1)-ABL1-gRNA1-exon4 eSpCas9(1.1)-ABL1-gRNA2-exon4
CTCF-mediated chromatin looping provides a topological framework for the formation of phase-separated transcriptional condensates. Lee R, Kang MK, Kim YJ, Yang B, Shim H, Kim S, Kim K, Yang CM, Min BG, Jung WJ, Lee EC, Joo JS, Park G, Cho WK, Kim HP. Nucleic Acids Res. 2022 Jan 11;50(1):207-226. doi: 10.1093/nar/gkab1242. PubMed
Coordination of Zika Virus Infection and Viroplasm Organization by Microtubules and Microtubule-Organizing Centers. Buchwalter RA, Ogden SC, York SB, Sun L, Zheng C, Hammack C, Cheng Y, Chen JV, Cone AS, Meckes DG Jr, Tang H, Megraw TL. Cells. 2021 Nov 27;10(12). pii: cells10123335. doi: 10.3390/cells10123335. PubMed
Human Renal Fibroblasts, but Not Renal Epithelial Cells, Induce IL-1beta Release during a Uropathogenic Escherichia coli Infection In Vitro. Kumawat AK, Paramel GV, Demirel KJ, Demirel I. Cells. 2021 Dec 13;10(12). pii: cells10123522. doi: 10.3390/cells10123522. PubMed
hnRNP Q and hnRNP A1 Regulate the Translation of Cofilin in Response to Transient Oxygen-Glucose Deprivation in Hippocampal Neurons. Kim SW, Hong IK, Kim M, Song YS, Kim KT. Cells. 2021 Dec 17;10(12). pii: cells10123567. doi: 10.3390/cells10123567. PubMed
Adenine base-editing-mediated exon skipping induces gene knockout in cultured pig cells. Zhu XX, Pan JS, Lin T, Yang YC, Huang QY, Yang SP, Qu ZX, Lin ZS, Wen JC, Yan AF, Feng J, Liu L, Zhang XL, Lu JH, Tang DS. Biotechnol Lett. 2022 Jan;44(1):59-76. doi: 10.1007/s10529-021-03214-x. Epub 2022 Jan 8. PubMed
Site-specific ubiquitination of MLKL targets it to endosomes and targets Listeria and Yersinia to the lysosomes. Yoon S, Bogdanov K, Wallach D. Cell Death Differ. 2022 Feb;29(2):306-322. doi: 10.1038/s41418-021-00924-7. Epub 2022 Jan 9. PubMed
Reduced RBPMS Levels Promote Cell Proliferation and Decrease Cisplatin Sensitivity in Ovarian Cancer Cells. Rabelo-Fernandez RJ, Santiago-Sanchez GS, Sharma RK, Roche-Lima A, Carrion KC, Rivera RAN, Quinones-Diaz BI, Rajasekaran S, Siddiqui J, Miles W, Rivera YS, Valiyeva F, Vivas-Mejia PE. Int J Mol Sci. 2022 Jan 4;23(1):535. doi: 10.3390/ijms23010535. PubMed
Grainyhead 1 acts as a drug-inducible conserved transcriptional regulator linked to insulin signaling and lifespan. Grigolon G, Araldi E, Erni R, Wu JY, Thomas C, La Fortezza M, Laube B, Pohlmann D, Stoffel M, Zarse K, Carreira EM, Ristow M, Fischer F. Nat Commun. 2022 Jan 10;13(1):107. doi: 10.1038/s41467-021-27732-4. PubMed Associated Plasmids pdestMB14_grh-1p-grh-1-gfp pdestMB14_hsp-16.2p-grh-1-gfp PX459_GRHL1-exon5 PX459_GRHL1-exon8 pcDNA3.1_Hygro(+)_GRHL1-L3F6H More ...
Proximity labeling identifies a repertoire of site-specific R-loop modulators. Yan Q, Wulfridge P, Doherty J, Fernandez-Luna JL, Real PJ, Tang HY, Sarma K. Nat Commun. 2022 Jan 10;13(1):53. doi: 10.1038/s41467-021-27722-6. PubMed
Allele-specific endogenous tagging and quantitative analysis of beta-catenin in colorectal cancer cells. Ambrosi G, Voloshanenko O, Eckert AF, Kranz D, Nienhaus GU, Boutros M. Elife. 2022 Jan 11;11. pii: 64498. doi: 10.7554/eLife.64498. PubMed
Loss of TREM2 rescues hyperactivation of microglia, but not lysosomal deficits and neurotoxicity in models of progranulin deficiency. Reifschneider A, Robinson S, van Lengerich B, Gnorich J, Logan T, Heindl S, Vogt MA, Weidinger E, Riedl L, Wind K, Zatcepin A, Pesamaa I, Haberl S, Nuscher B, Kleinberger G, Klimmt J, Gotzl JK, Liesz A, Burger K, Brendel M, Levin J, Diehl-Schmid J, Suh J, Di Paolo G, Lewcock JW, Monroe KM, Paquet D, Capell A, Haass C. EMBO J. 2022 Feb 15;41(4):e109108. doi: 10.15252/embj.2021109108. Epub 2022 Jan 12. PubMed
Dual role of Ovol2 on the germ cell lineage segregation during gastrulation in mouse embryogenesis. Naitou Y, Nagamatsu G, Hamazaki N, Shirane K, Hayashi M, Hayashi M, Kobayashi S, Hayashi K. Development. 2022 Feb 15;149(4). pii: 274415. doi: 10.1242/dev.200319. Epub 2022 Feb 18. PubMed
The METTL5-TRMT112 N(6)-methyladenosine methyltransferase complex regulates mRNA translation via 18S rRNA methylation. Sepich-Poore C, Zheng Z, Schmitt E, Wen K, Zhang ZS, Cui XL, Dai Q, Zhu AC, Zhang L, Sanchez Castillo A, Tan H, Peng J, Zhuang X, He C, Nachtergaele S. J Biol Chem. 2022 Mar;298(3):101590. doi: 10.1016/j.jbc.2022.101590. Epub 2022 Jan 14. PubMed
Truncated PARP1 mediates ADP-ribosylation of RNA polymerase III for apoptosis. Chen Q, Ma K, Liu X, Chen SH, Li P, Yu Y, Leung AKL, Yu X. Cell Discov. 2022 Jan 18;8(1):3. doi: 10.1038/s41421-021-00355-1. PubMed
CRISPR-Cas9 Screen Identifies DYRK1A as a Target for Radiotherapy Sensitization in Pancreatic Cancer. Lan B, Zeng S, Zhang S, Ren X, Xing Y, Kutschick I, Pfeffer S, Frey B, Britzen-Laurent N, Grutzmann R, Cordes N, Pilarsky C. Cancers (Basel). 2022 Jan 10;14(2). pii: cancers14020326. doi: 10.3390/cancers14020326. PubMed
Multiplexed Genome Editing via an RNA Polymerase II Promoter-Driven sgRNA Array in the Diatom Phaeodactylum tricornutum: Insights Into the Role of StLDP. Taparia Y, Dolui AK, Boussiba S, Khozin-Goldberg I. Front Plant Sci. 2022 Jan 4;12:784780. doi: 10.3389/fpls.2021.784780. eCollection 2021. PubMed
The mammalian trafficking chaperone protein UNC93B1 maintains the ER calcium sensor STIM1 in a dimeric state primed for translocation to the ER cortex. Wang WA, Demaurex N. J Biol Chem. 2022 Mar;298(3):101607. doi: 10.1016/j.jbc.2022.101607. Epub 2022 Jan 20. PubMed
Improved gRNA secondary structures allow editing of target sites resistant to CRISPR-Cas9 cleavage. Riesenberg S, Helmbrecht N, Kanis P, Maricic T, Paabo S. Nat Commun. 2022 Jan 25;13(1):489. doi: 10.1038/s41467-022-28137-7. PubMed
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Genetic Ablation of the MET Oncogene Defines a Crucial Role of the HGF/MET Axis in Cell-Autonomous Functions Driving Tumor Dissemination. Modica C, Cortese M, Bersani F, Lombardi AM, Napoli F, Righi L, Taulli R, Basilico C, Vigna E. Cancers (Basel). 2023 May 13;15(10):2742. doi: 10.3390/cancers15102742. PubMed
The chloride antiporter CLCN7 is a modifier of lysosome dysfunction in FIG4 and VAC14 mutants. Cao X, Lenk GM, Mikusevic V, Mindell JA, Meisler MH. PLoS Genet. 2023 Jun 26;19(6):e1010800. doi: 10.1371/journal.pgen.1010800. eCollection 2023 Jun. PubMed
3D Chromatin Architecture Re-Wiring at the CDH3/CDH1 Loci Contributes to E-Cadherin to P-Cadherin Expression Switch in Gastric Cancer. Sao Jose C, Pereira C, Ferreira M, Andre A, Osorio H, Gullo I, Carneiro F, Oliveira C. Biology (Basel). 2023 May 31;12(6):803. doi: 10.3390/biology12060803. PubMed
CRISPR-Cas12b enables a highly efficient attack on HIV proviral DNA in T cell cultures. Fan M, Bao Y, Berkhout B, Herrera-Carrillo E. Biomed Pharmacother. 2023 Sep;165:115046. doi: 10.1016/j.biopha.2023.115046. Epub 2023 Jun 28. PubMed
An ATG12-ATG5-TECPR1 E3-like complex regulates unconventional LC3 lipidation at damaged lysosomes. Corkery DP, Castro-Gonzalez S, Knyazeva A, Herzog LK, Wu YW. EMBO Rep. 2023 Sep 6;24(9):e56841. doi: 10.15252/embr.202356841. Epub 2023 Jun 29. PubMed
TP53RK Drives the Progression of Chronic Kidney Disease by Phosphorylating Birc5. Wu M, Jin Q, Xu X, Fan J, Chen W, Miao M, Gu R, Zhang S, Guo Y, Huang S, Zhang Y, Zhang A, Jia Z. Adv Sci (Weinh). 2023 Jun 29:e2301753. doi: 10.1002/advs.202301753. PubMed
Identification of VPS34-PI(3)P-FEN1-mediated DNA repair pathway as a potential drug target to overcome chemoresistance. Zhang X, Dan S, Pan X, Li J, Wei Q, Huang L, Kang B, Chen C. Biochem Biophys Res Commun. 2023 Sep 24;674:27-35. doi: 10.1016/j.bbrc.2023.06.079. Epub 2023 Jun 27. PubMed
Rescue of secretion of a rare-disease associated mis-folded mutant glycoprotein in UGGT1 knock-out mammalian cells. Tax G, Guay KP, Solda T, Hitchman CJ, Hill JC, Vasiljevic S, Lia A, Modenutti CP, Straatman KR, Santino A, Molinari M, Zitzmann N, Hebert DN, Roversi P, Trerotola M. bioRxiv. 2023 May 31:2023.05.30.542711. doi: 10.1101/2023.05.30.542711. Preprint. PubMed
TECPR1 is activated by damage-induced sphingomyelin exposure to mediate noncanonical autophagy. Kaur N, de la Ballina LR, Haukaas HS, Torgersen ML, Radulovic M, Munson MJ, Sabirsh A, Stenmark H, Simonsen A, Carlsson SR, Lystad AH. EMBO J. 2023 Jul 6:e113105. doi: 10.15252/embj.2022113105. PubMed
Interaction between host G3BP and viral nucleocapsid protein regulates SARS-CoV-2 replication. Yang Z, Johnson BA, Meliopoulos VA, Ju X, Zhang P, Hughes MP, Wu J, Koreski KP, Chang TC, Wu G, Hixon J, Duffner J, Wong K, Lemieux R, Lokugamage KG, Alvardo RE, Crocquet-Valdes PA, Walker DH, Plante KS, Plante JA, Weaver SC, Kim HJ, Meyers R, Schultz-Cherry S, Ding Q, Menachery VD, Taylor JP. bioRxiv. 2023 Jun 30:2023.06.29.546885. doi: 10.1101/2023.06.29.546885. Preprint. PubMed
TET1 facilitates specification of early human lineages including germ cells. Hsu FM, Wu QY, Fabyanic EB, Wei A, Wu H, Clark AT. iScience. 2023 Jun 21;26(7):107191. doi: 10.1016/j.isci.2023.107191. eCollection 2023 Jul 21. PubMed
ZnUMBA - a live imaging method to detect local barrier breaches. Higashi T, Stephenson RE, Schwayer C, Huljev K, Higashi AY, Heisenberg CP, Chiba H, Miller AL. J Cell Sci. 2023 Aug 1;136(15):jcs260668. doi: 10.1242/jcs.260668. Epub 2023 Aug 8. PubMed
SCN1A-deficient excitatory neuronal networks display mutation-specific phenotypes. van Hugte EJH, Lewerissa EI, Wu KM, Scheefhals N, Parodi G, van Voorst TW, Puvogel S, Kogo N, Keller JM, Frega M, Schubert D, Schelhaas HJ, Verhoeven J, Majoie M, van Bokhoven H, Nadif Kasri N. Brain. 2023 Jul 19:awad245. doi: 10.1093/brain/awad245. PubMed
Modification of surface glycan by expression of beta-1,4-N-acetyl-galactosaminyltransferase (B4GALNT2) confers resistance to multiple viruses infection in chicken fibroblast cell. Park JS, Woo SJ, Song CS, Han JY. Front Vet Sci. 2023 Jul 6;10:1160600. doi: 10.3389/fvets.2023.1160600. eCollection 2023. PubMed
Nitric oxide-induced ribosome collision activates ribosomal surveillance mechanisms. Ryder L, Arendrup FS, Martinez JF, Snieckute G, Pecorari C, Shah RA, Lund AH, Blasius M, Bekker-Jensen S. Cell Death Dis. 2023 Jul 26;14(7):467. doi: 10.1038/s41419-023-05997-5. PubMed
Evolutionarily divergent mTOR remodels translatome for tissue regeneration. Zhulyn O, Rosenblatt HD, Shokat L, Dai S, Kuzuoglu-Ozturk D, Zhang Z, Ruggero D, Shokat KM, Barna M. Nature. 2023 Aug;620(7972):163-171. doi: 10.1038/s41586-023-06365-1. Epub 2023 Jul 26. PubMed
Noncanonical functions of Ku may underlie essentiality in human cells. Kelly RD, Parmar G, Bayat L, Maitland MER, Lajoie GA, Edgell DR, Schild-Poulter C. Sci Rep. 2023 Jul 27;13(1):12162. doi: 10.1038/s41598-023-39166-7. PubMed
Disruption of the Mammalian Ccr4-Not Complex Contributes to Transcription-Mediated Genome Instability. Hagkarim NC, Hajkarim MC, Suzuki T, Fujiwara T, Winkler GS, Stewart GS, Grand RJ. Cells. 2023 Jul 17;12(14):1868. doi: 10.3390/cells12141868. PubMed
Loss of PARP7 Increases Type I Interferon Signaling in EO771 Breast Cancer Cells and Prevents Mammary Tumor Growth by Increasing Antitumor Immunity. Rasmussen M, Alvik K, Kannen V, Olafsen NE, Erlingsson LAM, Grimaldi G, Takaoka A, Grant DM, Matthews J. Cancers (Basel). 2023 Jul 20;15(14):3689. doi: 10.3390/cancers15143689. PubMed
Using a Dual CRISPR/Cas9 Approach to Gain Insight into the Role of LRP1B in Glioblastoma. Peixoto J, Principe C, Pestana A, Osorio H, Pinto MT, Prazeres H, Soares P, Lima RT. Int J Mol Sci. 2023 Jul 10;24(14):11285. doi: 10.3390/ijms241411285. PubMed
Generation of an induced pluripotent stem cell line carrying biallelic deletions (SCTCi019-B) in ALDH7A1 using CRISPR/Cas9. Schuurmans IME, Wu KM, van Karnebeek CDM, Nadif Kasri N, Garanto A. Stem Cell Res. 2023 Sep;71:103173. doi: 10.1016/j.scr.2023.103173. Epub 2023 Jul 28. PubMed
SETDB1 Methylates MCT1 Promoting Tumor Progression by Enhancing the Lactate Shuttle. She X, Wu Q, Rao Z, Song D, Huang C, Feng S, Liu A, Liu L, Wan K, Li X, Yu C, Qiu C, Luo X, Hu J, Wang G, Xu F, Sun L. Adv Sci (Weinh). 2023 Oct;10(28):e2301871. doi: 10.1002/advs.202301871. Epub 2023 Aug 4. PubMed
Identification of novel hypermethylated or hypomethylated CpG sites and genes associated with anthracycline-induced cardiomyopathy. Singh P, Zhou L, Shah DA, Cejas RB, Crossman DK, Jouni M, Magdy T, Wang X, Sharafeldin N, Hageman L, McKenna DE, Horvath S, Armenian SH, Balis FM, Hawkins DS, Keller FG, Hudson MM, Neglia JP, Ritchey AK, Ginsberg JP, Landier W, Burridge PW, Bhatia S. Sci Rep. 2023 Aug 4;13(1):12683. doi: 10.1038/s41598-023-39357-2. PubMed
Malonyl-CoA is a conserved endogenous ATP-competitive mTORC1 inhibitor. Nicastro R, Brohee L, Alba J, Nuchel J, Figlia G, Kipschull S, Gollwitzer P, Romero-Pozuelo J, Fernandes SA, Lamprakis A, Vanni S, Teleman AA, De Virgilio C, Demetriades C. Nat Cell Biol. 2023 Sep;25(9):1303-1318. doi: 10.1038/s41556-023-01198-6. Epub 2023 Aug 10. PubMed
Transposon delivery for CRISPR-based loss-of-function screen in mice identifies NF2 as a cooperating gene involved with the canonical WNT signaling molecular class of hepatocellular carcinoma. Keng VW, Chiu AP, To JC, Li XX, Linden MA, Amin K, Moriarity BS, Yusa K. Heliyon. 2023 Jul 28;9(8):e18774. doi: 10.1016/j.heliyon.2023.e18774. eCollection 2023 Aug. PubMed
Efficient delivery of a large-size Cas9-EGFP vector in porcine fetal fibroblasts using a Lonza 4D-Nucleofector system. Liu W, Wang X, Liu R, Liao Y, Peng Z, Jiang H, Jing Q, Xing Y. BMC Biotechnol. 2023 Aug 16;23(1):29. doi: 10.1186/s12896-023-00799-1. PubMed
Recruitment of the Histone Variant MacroH2A1 to the Pericentric Region Occurs upon Chromatin Relaxation and Is Responsible for Major Satellite Transcriptional Regulation. Recoules L, Tanguy Le Gac N, Moutahir F, Bystricky K, Lavigne AC. Cells. 2023 Aug 30;12(17):2175. doi: 10.3390/cells12172175. PubMed
Glucose-induced and ChREBP: MLX-mediated lipogenic program promotes hepatocellular carcinoma development. Yu A, Yu P, Zhu Y, Zhu R, Sun R, Ye D, Yu FX. Oncogene. 2023 Oct;42(43):3182-3193. doi: 10.1038/s41388-023-02831-2. Epub 2023 Sep 9. PubMed
Generation of isogenic models of Angelman syndrome and Prader-Willi syndrome in CRISPR/Cas9-engineered human embryonic stem cells. Gilmore RB, Gorka D, Stoddard CE, Cotney JL, Chamberlain SJ. bioRxiv [Preprint]. 2023 Aug 30:2023.08.30.555563. doi: 10.1101/2023.08.30.555563. PubMed
Synthetic circuits based on split Cas9 to detect cellular events. Przybyszewska-Podstawka A, Czapinski J, Kalafut J, Rivero-Muller A. Sci Rep. 2023 Sep 11;13(1):14988. doi: 10.1038/s41598-023-41367-z. PubMed
Multi-feature clustering of CTCF binding creates robustness for loop extrusion blocking and Topologically Associating Domain boundaries. Chang LH, Ghosh S, Papale A, Luppino JM, Miranda M, Piras V, Degrouard J, Edouard J, Poncelet M, Lecouvreur N, Bloyer S, Leforestier A, Joyce EF, Holcman D, Noordermeer D. Nat Commun. 2023 Sep 12;14(1):5615. doi: 10.1038/s41467-023-41265-y. PubMed
Subunit-specific inhibition of BK channels by piperine. Kshatri A, Rivero-Perez B, Giraldez T. Biophys J. 2023 Sep 12:S0006-3495(23)00558-1. doi: 10.1016/j.bpj.2023.09.002. PubMed
Generation of a tyrosine hydroxylase-2A-Cre knockin non-human primate model by homology-directed-repair-biased CRISPR genome editing. Yoshimatsu S, Okahara J, Yoshie J, Igarashi Y, Nakajima R, Sanosaka T, Qian E, Sato T, Kobayashi H, Morimoto S, Kishi N, Pillis DM, Malik P, Noce T, Okano H. Cell Rep Methods. 2023 Sep 25;3(9):100590. doi: 10.1016/j.crmeth.2023.100590. Epub 2023 Sep 14. PubMed
Generation of a familial hypercholesterolemia model in non-human primate. Sato A, Tsukiyama T, Komeno M, Iwatani C, Tsuchiya H, Kawamoto I, Murase M, Nakagawa T, Itagaki I, Seita Y, Matsumoto S, Nakaya M, Shimizu A, Yamada A, Ema M, Ogita H. Sci Rep. 2023 Sep 20;13(1):15649. doi: 10.1038/s41598-023-42763-1. PubMed
A mechanosensing mechanism controls plasma membrane shape homeostasis at the nanoscale. Quiroga X, Walani N, Disanza A, Chavero A, Mittens A, Tebar F, Trepat X, Parton RG, Geli MI, Scita G, Arroyo M, Le Roux AL, Roca-Cusachs P. Elife. 2023 Sep 25;12:e72316. doi: 10.7554/eLife.72316. PubMed
The Role of NLRP3 in Regulation of Antimicrobial Peptides and Estrogen Signaling in UPEC-Infected Bladder Epithelial Cells. Lindblad A, Wu R, Persson K, Demirel I. Cells. 2023 Sep 18;12(18):2298. doi: 10.3390/cells12182298. PubMed
A Side-by-Side Comparison of Wildtype and Variant Melanocortin 1 Receptor Signaling with Emphasis on Protection against Oxidative Damage to DNA. Cerdido S, Sanchez-Beltran J, Lambertos A, Abrisqueta M, Padilla L, Herraiz C, Olivares C, Jimenez-Cervantes C, Garcia-Borron JC. Int J Mol Sci. 2023 Sep 21;24(18):14381. doi: 10.3390/ijms241814381. PubMed
Rab41-mediated ESCRT machinery repairs membrane rupture by a bacterial toxin in xenophagy. Nozawa T, Toh H, Iibushi J, Kogai K, Minowa-Nozawa A, Satoh J, Ito S, Murase K, Nakagawa I. Nat Commun. 2023 Oct 6;14(1):6230. doi: 10.1038/s41467-023-42039-2. PubMed
Protocol for selecting single human pluripotent stem cells using a modified micropipetter. Mojica-Perez SP, Stokes K, Jaklic DC, Jahagirdar S, Uhler M, Parent JM, Niu W. STAR Protoc. 2023 Dec 15;4(4):102629. doi: 10.1016/j.xpro.2023.102629. Epub 2023 Oct 9. PubMed
Creating resistance to avian influenza infection through genome editing of the ANP32 gene family. Idoko-Akoh A, Goldhill DH, Sheppard CM, Bialy D, Quantrill JL, Sukhova K, Brown JC, Richardson S, Campbell C, Taylor L, Sherman A, Nazki S, Long JS, Skinner MA, Shelton H, Sang HM, Barclay WS, McGrew MJ. Nat Commun. 2023 Oct 10;14(1):6136. doi: 10.1038/s41467-023-41476-3. PubMed
Leveraging Tissue-Specific Enhancer-Target Gene Regulatory Networks Identifies Enhancer Somatic Mutations That Functionally Impact Lung Cancer. Hariprakash JM, Salviato E, La Mastra F, Sebestyen E, Tagliaferri I, Silva RS, Lucini F, Farina L, Cinquanta M, Rancati I, Riboni M, Minardi SP, Roz L, Gorini F, Lanzuolo C, Casola S, Ferrari F. Cancer Res. 2024 Jan 2;84(1):133-153. doi: 10.1158/0008-5472.CAN-23-1129. PubMed
Identifying key underlying regulatory networks and predicting targets of orphan C/D box SNORD116 snoRNAs in Prader-Willi syndrome. Gilmore RB, Liu Y, Stoddard CE, Chung MS, Carmichael GG, Cotney J. bioRxiv [Preprint]. 2023 Oct 5:2023.10.03.560773. doi: 10.1101/2023.10.03.560773. PubMed
Direct ionic stress sensing and mitigation by the transcription factor NFAT5. Khandwala CB, Sarkar P, Schmidt HB, Ma M, Kinnebrew M, Pusapati GV, Patel BB, Tillo D, Lebensohn AM, Rohatgi R. bioRxiv [Preprint]. 2023 Sep 24:2023.09.23.559074. doi: 10.1101/2023.09.23.559074. PubMed
ESYT1 tethers the ER to mitochondria and is required for mitochondrial lipid and calcium homeostasis. Janer A, Morris JL, Krols M, Antonicka H, Aaltonen MJ, Lin ZY, Anand H, Gingras AC, Prudent J, Shoubridge EA. Life Sci Alliance. 2023 Nov 6;7(1):e202302335. doi: 10.26508/lsa.202302335. Print 2024 Jan. PubMed
Generation of porcine PK-15 cells lacking the Ifnar1 or Stat2 gene to optimize the efficiency of viral isolation. Shofa M, Saito A. PLoS One. 2023 Nov 8;18(11):e0289863. doi: 10.1371/journal.pone.0289863. eCollection 2023. PubMed
The Complex Effects of PKM2 and PKM2:IP(3)R Disruption on Intracellular Ca(2+) Handling and Cellular Functions. Lemos FO, de Ridder I, Bootman MD, Bultynck G, Parys JB. Cells. 2023 Oct 26;12(21):2527. doi: 10.3390/cells12212527. PubMed
DLG1 functions upstream of SDCCAG3 and IFT20 to control ciliary targeting of polycystin-2. Rezi CK, Aslanyan MG, Diwan GD, Cheng T, Chamlali M, Junger K, Anvarian Z, Lorentzen E, Pauly KB, Afshar-Bahadori Y, Fernandes EFA, Qian F, Tosi S, Christensen ST, Pedersen SF, Stromgaard K, Russell RB, Miner JH, Mahjoub MR, Boldt K, Roepman R, Pedersen LB. bioRxiv [Preprint]. 2023 Dec 15:2023.11.10.566524. doi: 10.1101/2023.11.10.566524. PubMed
The AMPK-Sirtuin 1-YAP axis is regulated by fluid flow intensity and controls autophagy flux in kidney epithelial cells. Claude-Taupin A, Isnard P, Bagattin A, Kuperwasser N, Roccio F, Ruscica B, Goudin N, Garfa-Traore M, Regnier A, Turinsky L, Burtin M, Foretz M, Pontoglio M, Morel E, Viollet B, Terzi F, Codogno P, Dupont N. Nat Commun. 2023 Dec 5;14(1):8056. doi: 10.1038/s41467-023-43775-1. PubMed
NAK-associated protein 1/NAP1 activates TBK1 to ensure accurate mitosis and cytokinesis. Paul S, Sarraf SA, Nam KH, Zavar L, DeFoor N, Biswas SR, Fritsch LE, Yaron TM, Johnson JL, Huntsman EM, Cantley LC, Ordureau A, Pickrell AM. J Cell Biol. 2024 Feb 5;223(2):e202303082. doi: 10.1083/jcb.202303082. Epub 2023 Dec 7. PubMed Associated Plasmids pHAGE N' EGFP NAP1 FL IRES Blast pHAGE FL NAP1 STOP C' EGFP IRES Blast pHAGE-N'-FLAG-HA-NAP1S318A
A naturally occurring polyacetylene isolated from carrots promotes health and delays signatures of aging. Thomas C, Erni R, Wu JY, Fischer F, Lamers G, Grigolon G, Mitchell SJ, Zarse K, Carreira EM, Ristow M. Nat Commun. 2023 Dec 8;14(1):8142. doi: 10.1038/s41467-023-43672-7. PubMed
Phenotypic profiling of solute carriers characterizes serine transport in cancer. Papalazarou V, Newman AC, Huerta-Uribe A, Legrave NM, Falcone M, Zhang T, McGarry L, Athineos D, Shanks E, Blyth K, Vousden KH, Maddocks ODK. Nat Metab. 2023 Dec;5(12):2148-2168. doi: 10.1038/s42255-023-00936-2. Epub 2023 Dec 8. PubMed
Epigenetically Downregulated Breast Cancer Gene 2 through Acetyltransferase Lysine Acetyltransferase 2B Increases the Sensitivity of Colorectal Cancer to Olaparib. Chen S, Allgayer H. Cancers (Basel). 2023 Nov 25;15(23):5580. doi: 10.3390/cancers15235580. PubMed
The formation of ubiquitin rich condensates triggers recruitment of the ATG9A lipid transfer complex to initiate basal autophagy. Broadbent DG, McEwan CM, Tsang TM, Poole DM, Naylor BC, Price JC, Schmidt JC, Andersen JL. bioRxiv [Preprint]. 2023 Nov 29:2023.11.28.569058. doi: 10.1101/2023.11.28.569058. PubMed
cGAS-STING signalling regulates microglial chemotaxis in genome instability. Talbot EJ, Joshi L, Thornton P, Dezfouli M, Tsafou K, Perkinton M, Khoronenkova SV. Nucleic Acids Res. 2024 Feb 9;52(3):1188-1206. doi: 10.1093/nar/gkad1184. PubMed
Efficient selection of knocked-in pluripotent stem cells using a dual cassette cellular elimination system. Nakade K, Tsukamoto S, Nakashima K, An Y, Sato I, Li J, Shimoda Y, Hemmi Y, Miwa Y, Hayashi Y. Cell Rep Methods. 2023 Dec 18;3(12):100662. doi: 10.1016/j.crmeth.2023.100662. Epub 2023 Dec 11. PubMed
ZNF524 directly interacts with telomeric DNA and supports telomere integrity. Braun H, Xu Z, Chang F, Viceconte N, Rane G, Levin M, Lototska L, Roth F, Hillairet A, Fradera-Sola A, Khanchandani V, Sin ZW, Yong WK, Dreesen O, Yang Y, Shi Y, Li F, Butter F, Kappei D. Nat Commun. 2023 Dec 12;14(1):8252. doi: 10.1038/s41467-023-43397-7. PubMed
Noncoding function of super enhancer derived mRNA in modulating neighboring gene expression and TAD interaction. Xie B, Dean A. bioRxiv [Preprint]. 2023 Dec 5:2023.12.05.570115. doi: 10.1101/2023.12.05.570115. PubMed
Heterozygous Knockout of ARID4B Using CRISPR/Cas9 Attenuates Some Aggressive Phenotypes in a Breast Cancer Cell Line. Gonzalez-Salinas F, Herrera-Gamboa J, Rojo R, Trevino V. Genes (Basel). 2023 Dec 6;14(12):2184. doi: 10.3390/genes14122184. PubMed
Gain-of-Function KIDINS220 Variants Disrupt Neuronal Development and Cause Cerebral Palsy. Zhang J, Zhang Y, Shang Q, Cheng Y, Su Y, Zhang J, Wang T, Ding J, Li Y, Xie Y, Xing Q. Mov Disord. 2023 Dec 26. doi: 10.1002/mds.29694. PubMed
Construction and application of a multifunctional CHO cell platform utilizing Cre/lox and Dre/rox site-specific recombination systems. Zhang C, Chang F, Miao H, Fu Y, Tong X, Feng Y, Zheng W, Ma X. Front Bioeng Biotechnol. 2023 Dec 20;11:1320841. doi: 10.3389/fbioe.2023.1320841. eCollection 2023. PubMed
Nuclear pore protein POM121 regulates subcellular localization and transcriptional activity of PPARgamma. Yu Y, Farooq MS, Eberhart Meessen S, Jiang Y, Kato D, Zhan T, Weiss C, Seger R, Kang W, Zhang X, Yu J, Ebert MPA, Burgermeister E. Cell Death Dis. 2024 Jan 4;15(1):7. doi: 10.1038/s41419-023-06371-1. PubMed
DNA methylation restricts coordinated germline and neural fates in embryonic stem cell differentiation. Schulz M, Teissandier A, De La Mata Santaella E, Armand M, Iranzo J, El Marjou F, Gestraud P, Walter M, Kinston S, Gottgens B, Greenberg MVC, Bourc'his D. Nat Struct Mol Biol. 2024 Jan;31(1):102-114. doi: 10.1038/s41594-023-01162-w. Epub 2024 Jan 4. PubMed
Autotaxin-lysolipid signaling suppresses a CCL11-eosinophil axis to promote pancreatic cancer progression. Bhattacharyya S, Oon C, Diaz L, Sandborg H, Stempinski ES, Saoi M, Morgan TK, Lopez CS, Cross JR, Sherman MH. Nat Cancer. 2024 Feb;5(2):283-298. doi: 10.1038/s43018-023-00703-y. Epub 2024 Jan 9. PubMed
Synergistic Sensitization of High-Grade Serous Ovarian Cancer Cells Lacking Caspase-8 Expression to Chemotherapeutics Using Combinations of Small-Molecule BRD4 and CDK9 Inhibitors. Gasimli K, Raab M, Mandal R, Kramer A, Pena-Llopis S, Tahmasbi Rad M, Becker S, Strebhardt K, Sanhaji M. Cancers (Basel). 2023 Dec 24;16(1):107. doi: 10.3390/cancers16010107. PubMed
Diabetic sensory neuropathy and insulin resistance are induced by loss of UCHL1 in Drosophila. Lee D, Yoon E, Ham SJ, Lee K, Jang H, Woo D, Lee DH, Kim S, Choi S, Chung J. Nat Commun. 2024 Jan 11;15(1):468. doi: 10.1038/s41467-024-44747-9. PubMed
Mitochondrial stress activates YAP/TAZ through RhoA oxidation to promote liver injury. Kwon A, Lee NY, Yu JH, Choi MG, Park J, Koo JH. Cell Death Dis. 2024 Jan 15;15(1):51. doi: 10.1038/s41419-024-06448-5. PubMed
Investigation of the functional impact of CHED- and FECD4-associated SLC4A11 mutations in human corneal endothelial cells. Chung DD, Chen AC, Choo CH, Zhang W, Williams D, Griffis CG, Bonezzi P, Jatavallabhula K, Sampath AP, Aldave AJ. PLoS One. 2024 Jan 22;19(1):e0296928. doi: 10.1371/journal.pone.0296928. eCollection 2024. PubMed

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pSpCas9(BB)-2A-Puro (PX459) V2.0 Citations (1102)

Articles Citing pSpCas9(BB)-2A-Puro (PX459) V2.0

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