pCMV-VSV-G Citations (1589)
Originally described in: Lentivirus-delivered stable gene silencing by RNAi in primary cells.Stewart SA, Dykxhoorn DM, Palliser D, Mizuno H, Yu EY, An DS, Sabatini DM, Chen IS, Hahn WC, Sharp PA, Weinberg RA, Novina CD RNA 2003 Apr;9(4):493-501. PubMed Journal
Articles Citing pCMV-VSV-G
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| Coactivation of janus tyrosine kinase (Jak)1 positively modulates prolactin-Jak2 signaling in breast cancer: recruitment of ERK and signal transducer and activator of transcription (Stat)3 and enhancement of Akt and Stat5a/b pathways. Neilson LM, Zhu J, Xie J, Malabarba MG, Sakamoto K, Wagner KU, Kirken RA, Rui H. Mol Endocrinol. 2007 Sep . 21(9):2218-32. PubMed |
| Role of GLI2 transcription factor in growth and tumorigenicity of prostate cells. Thiyagarajan S, Bhatia N, Reagan-Shaw S, Cozma D, Thomas-Tikhonenko A, Ahmad N, Spiegelman VS. Cancer Res. 2007 Nov 15;67(22):10642-6. PubMed |
| mTORC2 activity is elevated in gliomas and promotes growth and cell motility via overexpression of rictor. Masri J, Bernath A, Martin J, Jo OD, Vartanian R, Funk A, Gera J. Cancer Res. 2007 Dec 15. 67(24):11712-20. PubMed |
| Generation of human-induced pluripotent stem cells. Park IH, Lerou PH, Zhao R, Huo H, Daley GQ. Nat Protoc. 2008 . 3(7):1180-6. PubMed |
| XRCC1 protects against the lethality of induced oxidative DNA damage in nondividing neural cells. Kulkarni A, McNeill DR, Gleichmann M, Mattson MP, Wilson DM 3rd. Nucleic Acids Res. 2008 Sep;36(15):5111-21. doi: 10.1093/nar/gkn480. Epub 2008 Aug 5. PubMed |
| A myelopoiesis-associated regulatory intergenic noncoding RNA transcript within the human HOXA cluster. Zhang X, Lian Z, Padden C, Gerstein MB, Rozowsky J, Snyder M, Gingeras TR, Kapranov P, Weissman SM, Newburger PE. Blood. 2009 Mar 12;113(11):2526-34. doi: 10.1182/blood-2008-06-162164. Epub 2009 Jan 14. PubMed |
| Human iPS cell derivation/reprogramming. Park IH, Daley GQ. Curr Protoc Stem Cell Biol. 2009 Jan;Chapter 4:Unit 4A.1. doi: 10.1002/9780470151808.sc04a01s8. PubMed |
| The transcription of FOXO genes is stimulated by FOXO3 and repressed by growth factors. Essaghir A, Dif N, Marbehant CY, Coffer PJ, Demoulin JB. J Biol Chem. 2009 Apr 17;284(16):10334-42. doi: 10.1074/jbc.M808848200. Epub 2009 Feb 24. PubMed |
| Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus (KSHV) upregulates survivin expression in KSHV-Associated B-lymphoma cells and contributes to their proliferation. Lu J, Verma SC, Murakami M, Cai Q, Kumar P, Xiao B, Robertson ES. J Virol. 2009 Jul;83(14):7129-41. doi: 10.1128/JVI.00397-09. Epub 2009 May 13. PubMed |
| Site-specific mTOR phosphorylation promotes mTORC1-mediated signaling and cell growth. Acosta-Jaquez HA, Keller JA, Foster KG, Ekim B, Soliman GA, Feener EP, Ballif BA, Fingar DC. Mol Cell Biol. 2009 Aug;29(15):4308-24. doi: 10.1128/MCB.01665-08. Epub 2009 Jun 1. PubMed |
| Conditional mouse lung cancer models using adenoviral or lentiviral delivery of Cre recombinase. DuPage M, Dooley AL, Jacks T. Nat Protoc. 2009;4(7):1064-72. doi: 10.1038/nprot.2009.95. Epub 2009 Jun 25. PubMed |
| Enhanced generation of induced pluripotent stem cells from a subpopulation of human fibroblasts. Byrne JA, Nguyen HN, Reijo Pera RA. PLoS One. 2009 Sep 23;4(9):e7118. doi: 10.1371/journal.pone.0007118. PubMed |
| TAPP2 links phosphoinositide 3-kinase signaling to B-cell adhesion through interaction with the cytoskeletal protein utrophin: expression of a novel cell adhesion-promoting complex in B-cell leukemia. Costantini JL, Cheung SM, Hou S, Li H, Kung SK, Johnston JB, Wilkins JA, Gibson SB, Marshall AJ. Blood. 2009 Nov 19;114(21):4703-12. doi: 10.1182/blood-2009-03-213058. Epub 2009 Sep 28. PubMed |
| Generation of induced pluripotent stem cells from neural stem cells. Kim JB, Zaehres H, Arauzo-Bravo MJ, Scholer HR. Nat Protoc. 2009;4(10):1464-70. doi: 10.1038/nprot.2009.173. Epub 2009 Sep 17. PubMed |
| Mouse and human induced pluripotent stem cells as a source for multipotent Isl1+ cardiovascular progenitors. Moretti A, Bellin M, Jung CB, Thies TM, Takashima Y, Bernshausen A, Schiemann M, Fischer S, Moosmang S, Smith AG, Lam JT, Laugwitz KL. FASEB J. 2010 Mar;24(3):700-11. doi: 10.1096/fj.09-139477. Epub 2009 Oct 22. PubMed |
| Developmental stages of the Japanese quail. Ainsworth SJ, Stanley RL, Evans DJ. J Anat. 2010 Jan;216(1):3-15. doi: 10.1111/j.1469-7580.2009.01173.x. Epub 2009 Nov 19. PubMed |
| Functional analysis of the Cdk7.cyclin H.Mat1 complex in mouse embryonic stem cells and embryos. Patel SA, Simon MC. J Biol Chem. 2010 May 14;285(20):15587-98. doi: 10.1074/jbc.M109.081687. Epub 2010 Mar 15. PubMed |
| Transmembrane protein 147 (TMEM147) is a novel component of the Nicalin-NOMO protein complex. Dettmer U, Kuhn PH, Abou-Ajram C, Lichtenthaler SF, Kruger M, Kremmer E, Haass C, Haffner C. J Biol Chem. 2010 Aug 20;285(34):26174-81. doi: 10.1074/jbc.M110.132548. Epub 2010 Jun 10. PubMed |
| Exploration of self-renewal and pluripotency in ES cells using RNAi. Schaniel C, Lee DF, Lemischka IR. Methods Enzymol. 2010;477:351-65. doi: 10.1016/S0076-6879(10)77018-X. PubMed |
| PTP1B suppresses prolactin activation of Stat5 in breast cancer cells. Johnson KJ, Peck AR, Liu C, Tran TH, Utama FE, Sjolund AB, Schaber JD, Witkiewicz AK, Rui H. Am J Pathol. 2010 Dec;177(6):2971-83. doi: 10.2353/ajpath.2010.090399. Epub 2010 Oct 15. PubMed |
Large intergenic non-coding RNA-RoR modulates reprogramming of human induced pluripotent stem cells.
Loewer S, Cabili MN, Guttman M, Loh YH, Thomas K, Park IH, Garber M, Curran M, Onder T, Agarwal S, Manos PD, Datta S, Lander ES, Schlaeger TM, Daley GQ, Rinn JL.
Nat Genet. 2010 Dec;42(12):1113-7. Epub 2010 Nov 7.
PubMed
Associated Plasmids |
| Generation of pig iPS cells: a model for cell therapy. Montserrat N, Bahima EG, Batlle L, Hafner S, Rodrigues AM, Gonzalez F, Izpisua Belmonte JC. J Cardiovasc Transl Res. 2011 Apr;4(2):121-30. doi: 10.1007/s12265-010-9233-3. Epub 2010 Nov 19. PubMed |
| Feeder-dependent and feeder-independent iPS cell derivation from human and mouse adipose stem cells. Sugii S, Kida Y, Berggren WT, Evans RM. Nat Protoc. 2011 Mar;6(3):346-58. doi: 10.1038/nprot.2010.199. Epub 2011 Feb 24. PubMed |
| Differentiation and neuro-protective properties of immortalized human tooth germ stem cells. Yalvac ME, Yilmaz A, Mercan D, Aydin S, Dogan A, Arslan A, Demir Z, Salafutdinov II, Shafigullina AK, Sahin F, Rizvanov AA, Palotas A. Neurochem Res. 2011 Dec;36(12):2227-35. doi: 10.1007/s11064-011-0546-7. Epub 2011 Jul 22. PubMed |
| Checkpoint kinase 1 prevents cell cycle exit linked to terminal cell differentiation. Ullah Z, de Renty C, DePamphilis ML. Mol Cell Biol. 2011 Oct;31(19):4129-43. doi: 10.1128/MCB.05723-11. Epub 2011 Jul 26. PubMed |
| Growth differentiation factor 15 (GDF15)-mediated HER2 phosphorylation reduces trastuzumab sensitivity of HER2-overexpressing breast cancer cells. Joshi JP, Brown NE, Griner SE, Nahta R. Biochem Pharmacol. 2011 Nov 1;82(9):1090-9. doi: 10.1016/j.bcp.2011.07.082. Epub 2011 Jul 23. PubMed |
| Quantitative fluorescence imaging of protein diffusion and interaction in living cells. Capoulade J, Wachsmuth M, Hufnagel L, Knop M. Nat Biotechnol. 2011 Aug 7;29(9):835-9. doi: 10.1038/nbt.1928. PubMed |
| Generation of induced pluripotent stem cell lines from human fibroblasts via retroviral gene transfer. Miller JD, Schlaeger TM. Methods Mol Biol. 2011;767:55-65. doi: 10.1007/978-1-61779-201-4_5. PubMed |
| GADD45A protein plays an essential role in active DNA demethylation during terminal osteogenic differentiation of adipose-derived mesenchymal stem cells. Zhang RP, Shao JZ, Xiang LX. J Biol Chem. 2011 Nov 25;286(47):41083-94. doi: 10.1074/jbc.M111.258715. Epub 2011 Sep 14. PubMed |
| A Trio-RhoA-Shroom3 pathway is required for apical constriction and epithelial invagination. Plageman TF Jr, Chauhan BK, Yang C, Jaudon F, Shang X, Zheng Y, Lou M, Debant A, Hildebrand JD, Lang RA. Development. 2011 Dec;138(23):5177-88. doi: 10.1242/dev.067868. Epub 2011 Oct 26. PubMed |
| Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma. Landreville S, Agapova OA, Matatall KA, Kneass ZT, Onken MD, Lee RS, Bowcock AM, Harbour JW. Clin Cancer Res. 2012 Jan 15;18(2):408-16. doi: 10.1158/1078-0432.CCR-11-0946. Epub 2011 Oct 28. PubMed |
| Quantification of HIV-based lentiviral vectors: influence of several cell type parameters on vector infectivity. Gay V, Moreau K, Hong SS, Ronfort C. Arch Virol. 2012 Feb;157(2):217-23. doi: 10.1007/s00705-011-1150-5. Epub 2011 Oct 29. PubMed |
| FGF signalling inhibits neural induction in human embryonic stem cells. Greber B, Coulon P, Zhang M, Moritz S, Frank S, Muller-Molina AJ, Arauzo-Bravo MJ, Han DW, Pape HC, Scholer HR. EMBO J. 2011 Nov 15;30(24):4874-84. doi: 10.1038/emboj.2011.407. PubMed |
| Ran is a potential therapeutic target for cancer cells with molecular changes associated with activation of the PI3K/Akt/mTORC1 and Ras/MEK/ERK pathways. Yuen HF, Chan KK, Grills C, Murray JT, Platt-Higgins A, Eldin OS, O'Byrne K, Janne P, Fennell DA, Johnston PG, Rudland PS, El-Tanani M. Clin Cancer Res. 2012 Jan 15;18(2):380-91. doi: 10.1158/1078-0432.CCR-11-2035. Epub 2011 Nov 16. PubMed |
| Synthesis of cytochrome C oxidase 2: a p53-dependent metabolic regulator that promotes respiratory function and protects glioma and colon cancer cells from hypoxia-induced cell death. Wanka C, Brucker DP, Bahr O, Ronellenfitsch M, Weller M, Steinbach JP, Rieger J. Oncogene. 2012 Aug 16;31(33):3764-76. doi: 10.1038/onc.2011.530. Epub 2011 Nov 28. PubMed |
| Epstein-Barr virus nuclear antigen 3C stabilizes Gemin3 to block p53-mediated apoptosis. Cai Q, Guo Y, Xiao B, Banerjee S, Saha A, Lu J, Glisovic T, Robertson ES. PLoS Pathog. 2011 Dec;7(12):e1002418. doi: 10.1371/journal.ppat.1002418. Epub 2011 Dec 8. PubMed |
| Reprogramming of mouse, rat, pig, and human fibroblasts into iPS cells. Rajarajan K, Engels MC, Wu SM. Curr Protoc Mol Biol. 2012 Jan;Chapter 23:Unit 23.15.. doi: 10.1002/0471142727.mb2315s97. PubMed |
| Potassium channel mutant KCNJ5 T158A expression in HAC-15 cells increases aldosterone synthesis. Oki K, Plonczynski MW, Luis Lam M, Gomez-Sanchez EP, Gomez-Sanchez CE. Endocrinology. 2012 Apr;153(4):1774-82. doi: 10.1210/en.2011-1733. Epub 2012 Feb 7. PubMed |
| Peroxisome proliferator-activated receptor beta/delta induces myogenesis by modulating myostatin activity. Bonala S, Lokireddy S, Arigela H, Teng S, Wahli W, Sharma M, McFarlane C, Kambadur R. J Biol Chem. 2012 Apr 13;287(16):12935-51. doi: 10.1074/jbc.M111.319145. Epub 2012 Feb 23. PubMed |
| Derivation of mesenchymal stem cells from human induced pluripotent stem cells cultured on synthetic substrates. Villa-Diaz LG, Brown SE, Liu Y, Ross AM, Lahann J, Parent JM, Krebsbach PH. Stem Cells. 2012 Jun;30(6):1174-81. doi: 10.1002/stem.1084. PubMed |
| Combining competition assays with genetic complementation strategies to dissect mouse embryonic stem cell self-renewal and pluripotency. Lee DF, Su J, Sevilla A, Gingold J, Schaniel C, Lemischka IR. Nat Protoc. 2012 Mar 22;7(4):729-48. doi: 10.1038/nprot.2012.018. PubMed |
| Cockayne syndrome group B protein prevents the accumulation of damaged mitochondria by promoting mitochondrial autophagy. Scheibye-Knudsen M, Ramamoorthy M, Sykora P, Maynard S, Lin PC, Minor RK, Wilson DM 3rd, Cooper M, Spencer R, de Cabo R, Croteau DL, Bohr VA. J Exp Med. 2012 Apr 9;209(4):855-69. doi: 10.1084/jem.20111721. Epub 2012 Apr 2. PubMed |
| Excision of a viral reprogramming cassette by delivery of synthetic Cre mRNA. Loh YH, Yang JC, De Los Angeles A, Guo C, Cherry A, Rossi DJ, Park IH, Daley GQ. Curr Protoc Stem Cell Biol. 2012;Chapter 4:Unit4A.5. doi: 10.1002/9780470151808.sc04a05s21. PubMed |
| Maternal obesity downregulates microRNA let-7g expression, a possible mechanism for enhanced adipogenesis during ovine fetal skeletal muscle development. Yan X, Huang Y, Zhao JX, Rogers CJ, Zhu MJ, Ford SP, Nathanielsz PW, Du M. Int J Obes (Lond). 2013 Apr;37(4):568-75. doi: 10.1038/ijo.2012.69. Epub 2012 May 22. PubMed |
| MARCKS regulates growth and radiation sensitivity and is a novel prognostic factor for glioma. Jarboe JS, Anderson JC, Duarte CW, Mehta T, Nowsheen S, Hicks PH, Whitley AC, Rohrbach TD, McCubrey RO, Chiu S, Burleson TM, Bonner JA, Gillespie GY, Yang ES, Willey CD. Clin Cancer Res. 2012 Jun 1;18(11):3030-41. doi: 10.1158/1078-0432.CCR-11-3091. Epub 2012 May 22. PubMed |
| Human TSC-associated renal angiomyolipoma cells are hypersensitive to ER stress. Siroky BJ, Yin H, Babcock JT, Lu L, Hellmann AR, Dixon BP, Quilliam LA, Bissler JJ. Am J Physiol Renal Physiol. 2012 Sep 15;303(6):F831-44. doi: 10.1152/ajprenal.00441.2011. Epub 2012 Jul 11. PubMed |
| The extent of degeneration of cruciate ligament is associated with chondrogenic differentiation in patients with osteoarthritis of the knee. Kumagai K, Sakai K, Kusayama Y, Akamatsu Y, Sakamaki K, Morita S, Sasaki T, Saito T, Sakai T. Osteoarthritis Cartilage. 2012 Nov;20(11):1258-67. doi: 10.1016/j.joca.2012.07.013. Epub 2012 Jul 27. PubMed |
| Small molecule-assisted, line-independent maintenance of human pluripotent stem cells in defined conditions. Frank S, Zhang M, Scholer HR, Greber B. PLoS One. 2012;7(7):e41958. doi: 10.1371/journal.pone.0041958. Epub 2012 Jul 30. PubMed |
| Codon-usage-based inhibition of HIV protein synthesis by human schlafen 11. Li M, Kao E, Gao X, Sandig H, Limmer K, Pavon-Eternod M, Jones TE, Landry S, Pan T, Weitzman MD, David M. Nature. 2012 Nov 1;491(7422):125-8. doi: 10.1038/nature11433. Epub 2012 Sep 23. PubMed |
| Defining Akt actions in muscle differentiation. Gardner S, Anguiano M, Rotwein P. Am J Physiol Cell Physiol. 2012 Dec 15;303(12):C1292-300. doi: 10.1152/ajpcell.00259.2012. Epub 2012 Oct 17. PubMed |
| Growth differentiation factor 15 stimulates rapamycin-sensitive ovarian cancer cell growth and invasion. Griner SE, Joshi JP, Nahta R. Biochem Pharmacol. 2013 Jan 1;85(1):46-58. doi: 10.1016/j.bcp.2012.10.007. Epub 2012 Oct 17. PubMed |
| Loss of NF1 expression in human endothelial cells promotes autonomous proliferation and altered vascular morphogenesis. Bajaj A, Li QF, Zheng Q, Pumiglia K. PLoS One. 2012;7(11):e49222. doi: 10.1371/journal.pone.0049222. Epub 2012 Nov 7. PubMed |
| Phytochemicals attenuating aberrant activation of beta-catenin in cancer cells. Wang D, Wise ML, Li F, Dey M. PLoS One. 2012;7(12):e50508. doi: 10.1371/journal.pone.0050508. Epub 2012 Dec 3. PubMed |
| High-mobility group box 2 (HMGB2) modulates radioresponse and is downregulated by p53 in colorectal cancer cell. Shin YJ, Kim MS, Kim MS, Lee J, Kang M, Jeong JH. Cancer Biol Ther. 2013 Mar;14(3):213-21. doi: 10.4161/cbt.23292. Epub 2012 Dec 19. PubMed |
| On-target JAK2/STAT3 inhibition slows disease progression in orthotopic xenografts of human glioblastoma brain tumor stem cells. Stechishin OD, Luchman HA, Ruan Y, Blough MD, Nguyen SA, Kelly JJ, Cairncross JG, Weiss S. Neuro Oncol. 2013 Feb;15(2):198-207. doi: 10.1093/neuonc/nos302. Epub 2012 Dec 21. PubMed |
| Gene transduction in human monocyte-derived dendritic cells using lentiviral vectors. Satoh T, Manel N. Methods Mol Biol. 2013;960:401-9. doi: 10.1007/978-1-62703-218-6_30. PubMed |
| Patient-derived models of human breast cancer: protocols for in vitro and in vivo applications in tumor biology and translational medicine. DeRose YS, Gligorich KM, Wang G, Georgelas A, Bowman P, Courdy SJ, Welm AL, Welm BE. Curr Protoc Pharmacol. 2013 Mar;Chapter 14:Unit14.23. doi: 10.1002/0471141755.ph1423s60. PubMed |
| Genetic correction of a LRRK2 mutation in human iPSCs links parkinsonian neurodegeneration to ERK-dependent changes in gene expression. Reinhardt P, Schmid B, Burbulla LF, Schondorf DC, Wagner L, Glatza M, Hoing S, Hargus G, Heck SA, Dhingra A, Wu G, Muller S, Brockmann K, Kluba T, Maisel M, Kruger R, Berg D, Tsytsyura Y, Thiel CS, Psathaki OE, Klingauf J, Kuhlmann T, Klewin M, Muller H, Gasser T, Scholer HR, Sterneckert J. Cell Stem Cell. 2013 Mar 7;12(3):354-67. doi: 10.1016/j.stem.2013.01.008. PubMed |
| Rapamycin-treated human endothelial cells preferentially activate allogeneic regulatory T cells. Wang C, Yi T, Qin L, Maldonado RA, von Andrian UH, Kulkarni S, Tellides G, Pober JS. J Clin Invest. 2013 Apr;123(4):1677-93. doi: 10.1172/JCI66204. Epub 2013 Mar 8. PubMed |
| Derivation and expansion using only small molecules of human neural progenitors for neurodegenerative disease modeling. Reinhardt P, Glatza M, Hemmer K, Tsytsyura Y, Thiel CS, Hoing S, Moritz S, Parga JA, Wagner L, Bruder JM, Wu G, Schmid B, Ropke A, Klingauf J, Schwamborn JC, Gasser T, Scholer HR, Sterneckert J. PLoS One. 2013;8(3):e59252. doi: 10.1371/journal.pone.0059252. Epub 2013 Mar 22. PubMed |
| Rap2b, a novel p53 target, regulates p53-mediated pro-survival function. Zhang X, He Y, Lee KH, Dubois W, Li Z, Wu X, Kovalchuk A, Zhang W, Huang J. Cell Cycle. 2013 Apr 15;12(8):1279-91. doi: 10.4161/cc.24364. Epub 2013 Mar 27. PubMed |
| Protein impurities from cell culture dramatically impact transduction efficiency of polymer/virus hybrid vectors. Vupputuri S, Karode S, Neely BJ, Ramsey JD. J Virol Methods. 2013 Sep;192(1-2):1-11. doi: 10.1016/j.jviromet.2013.04.007. Epub 2013 Apr 16. PubMed |
| Mammalian target of rapamycin complex 1 (mTORC1) enhances bortezomib-induced death in tuberous sclerosis complex (TSC)-null cells by a c-MYC-dependent induction of the unfolded protein response. Babcock JT, Nguyen HB, He Y, Hendricks JW, Wek RC, Quilliam LA. J Biol Chem. 2013 May 31;288(22):15687-98. doi: 10.1074/jbc.M112.431056. Epub 2013 Apr 23. PubMed |
| Lentiviral vector production, titration, and transduction of primary neurons. Ding B, Kilpatrick DL. Methods Mol Biol. 2013;1018:119-31. doi: 10.1007/978-1-62703-444-9_12. PubMed |
| The RecQ helicase RECQL5 participates in psoralen-induced interstrand cross-link repair. Ramamoorthy M, May A, Tadokoro T, Popuri V, Seidman MM, Croteau DL, Bohr VA. Carcinogenesis. 2013 Oct;34(10):2218-30. doi: 10.1093/carcin/bgt183. Epub 2013 May 28. PubMed |
| BAP1 deficiency causes loss of melanocytic cell identity in uveal melanoma. Matatall KA, Agapova OA, Onken MD, Worley LA, Bowcock AM, Harbour JW. BMC Cancer. 2013 Aug 5;13:371. doi: 10.1186/1471-2407-13-371. PubMed |
| The ING4 Binding with p53 and Induced p53 Acetylation were Attenuated by Human Papillomavirus 16 E6. Guo Y, Meng X, Wang Q, Wang Y, Shang H. PLoS One. 2013 Aug 13;8(8):e71453. doi: 10.1371/journal.pone.0071453. eCollection 2013. PubMed |
| Generation of porcine induced pluripotent stem cells and evaluation of their major histocompatibility complex protein expression in vitro. Park KM, Cha SH, Ahn C, Woo HM. Vet Res Commun. 2013 Dec;37(4):293-301. doi: 10.1007/s11259-013-9574-x. Epub 2013 Aug 23. PubMed |
| Evaluation of the molecular mechanisms of a palladium(II) saccharinate complex with terpyridine as an anticancer agent. Kacar O, Adiguzel Z, Yilmaz VT, Cetin Y, Cevatemre B, Arda N, Baykal AT, Ulukaya E, Acilan C. Anticancer Drugs. 2014 Jan;25(1):17-29. doi: 10.1097/CAD.0b013e328364c6ad. PubMed |
| Autophagy sensitivity of neuroendocrine lung tumor cells. Hong SK, Kim JH, Starenki D, Park JI. Int J Oncol. 2013 Dec;43(6):2031-8. doi: 10.3892/ijo.2013.2136. Epub 2013 Oct 11. PubMed |
| Acidosis decreases c-Myc oncogene expression in human lymphoma cells: a role for the proton-sensing G protein-coupled receptor TDAG8. Li Z, Dong L, Dean E, Yang LV. Int J Mol Sci. 2013 Oct 11;14(10):20236-55. doi: 10.3390/ijms141020236. PubMed |
| Lentiviral overexpression of miRNAs. Zollner H, Hahn SA, Maghnouj A. Methods Mol Biol. 2014;1095:177-90. doi: 10.1007/978-1-62703-703-7_15. PubMed |
| PRDM14 promotes active DNA demethylation through the ten-eleven translocation (TET)-mediated base excision repair pathway in embryonic stem cells. Okashita N, Kumaki Y, Ebi K, Nishi M, Okamoto Y, Nakayama M, Hashimoto S, Nakamura T, Sugasawa K, Kojima N, Takada T, Okano M, Seki Y. Development. 2014 Jan;141(2):269-80. doi: 10.1242/dev.099622. Epub 2013 Dec 11. PubMed |
| TGF-beta receptor type-2 expression in cancer-associated fibroblasts regulates breast cancer cell growth and survival and is a prognostic marker in pre-menopausal breast cancer. Busch S, Acar A, Magnusson Y, Gregersson P, Ryden L, Landberg G. Oncogene. 2015 Jan 2;34(1):27-38. doi: 10.1038/onc.2013.527. Epub 2013 Dec 16. PubMed |
| Automated analysis of clonal cancer cells by intravital imaging. Coffey SE, Giedt RJ, Weissleder R. Intravital. 2013 Jul;2(3). doi: 10.4161/intv.26138. PubMed |
| Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging. Gomes AP, Price NL, Ling AJ, Moslehi JJ, Montgomery MK, Rajman L, White JP, Teodoro JS, Wrann CD, Hubbard BP, Mercken EM, Palmeira CM, de Cabo R, Rolo AP, Turner N, Bell EL, Sinclair DA. Cell. 2013 Dec 19;155(7):1624-38. doi: 10.1016/j.cell.2013.11.037. PubMed |
| Gene delivery in malignant B cells using the combination of lentiviruses conjugated to anti-transferrin receptor antibodies and an immunoglobulin promoter. Leoh LS, Morizono K, Kershaw KM, Chen IS, Penichet ML, Daniels-Wells TR. J Gene Med. 2014 Jan-Feb;16(1-2):11-27. doi: 10.1002/jgm.2754. PubMed |
| Plakoglobin but not desmoplakin regulates keratinocyte cohesion via modulation of p38MAPK signaling. Spindler V, Dehner C, Hubner S, Waschke J. J Invest Dermatol. 2014 Jun;134(6):1655-64. doi: 10.1038/jid.2014.21. Epub 2014 Jan 17. PubMed |
| Myostatin induces insulin resistance via Casitas B-lineage lymphoma b (Cblb)-mediated degradation of insulin receptor substrate 1 (IRS1) protein in response to high calorie diet intake. Bonala S, Lokireddy S, McFarlane C, Patnam S, Sharma M, Kambadur R. J Biol Chem. 2014 Mar 14;289(11):7654-70. doi: 10.1074/jbc.M113.529925. Epub 2014 Jan 22. PubMed |
| Rapamycin antagonizes TNF induction of VCAM-1 on endothelial cells by inhibiting mTORC2. Wang C, Qin L, Manes TD, Kirkiles-Smith NC, Tellides G, Pober JS. J Exp Med. 2014 Mar 10;211(3):395-404. doi: 10.1084/jem.20131125. Epub 2014 Feb 10. PubMed |
| Rapid cellular phenotyping of human pluripotent stem cell-derived cardiomyocytes using a genetically encoded fluorescent voltage sensor. Leyton-Mange JS, Mills RW, Macri VS, Jang MY, Butte FN, Ellinor PT, Milan DJ. Stem Cell Reports. 2014 Feb 6;2(2):163-70. doi: 10.1016/j.stemcr.2014.01.003. eCollection 2014 Feb 11. PubMed |
| IQGAP1 binds to estrogen receptor-alpha and modulates its function. Erdemir HH, Li Z, Sacks DB. J Biol Chem. 2014 Mar 28;289(13):9100-12. doi: 10.1074/jbc.M114.553511. Epub 2014 Feb 18. PubMed |
| A differential role for CXCR4 in the regulation of normal versus malignant breast stem cell activity. Ablett MP, O'Brien CS, Sims AH, Farnie G, Clarke RB. Oncotarget. 2014 Feb 15;5(3):599-612. PubMed |
| Resistance to mTOR kinase inhibitors in lymphoma cells lacking 4EBP1. Mallya S, Fitch BA, Lee JS, So L, Janes MR, Fruman DA. PLoS One. 2014 Feb 21;9(2):e88865. doi: 10.1371/journal.pone.0088865. eCollection 2014. PubMed |
Anoctamin 6 regulates C2C12 myoblast proliferation.
Zhao P, Torcaso A, Mariano A, Xu L, Mohsin S, Zhao L, Han R.
PLoS One. 2014 Mar 24;9(3):e92749. doi: 10.1371/journal.pone.0092749. eCollection 2014.
PubMed
Associated Plasmids |
MYPT1 regulates contractility and microtubule acetylation to modulate integrin adhesions and matrix assembly.
Joo EE, Yamada KM.
Nat Commun. 2014 Mar 25;5:3510. doi: 10.1038/ncomms4510.
PubMed
Associated Plasmids |
| Regulation of fibulin-2 gene expression by integrin alpha3beta1 contributes to the invasive phenotype of transformed keratinocytes. Missan DS, Chittur SV, DiPersio CM. J Invest Dermatol. 2014 Sep;134(9):2418-27. doi: 10.1038/jid.2014.166. Epub 2014 Apr 2. PubMed |
| Hypoxia enhances the antiglioma cytotoxicity of B10, a glycosylated derivative of betulinic acid. Fischer S, Ronellenfitsch MW, Thiepold AL, Harter PN, Reichert S, Kogel D, Paschke R, Mittelbronn M, Weller M, Steinbach JP, Fulda S, Bahr O. PLoS One. 2014 Apr 17;9(4):e94921. doi: 10.1371/journal.pone.0094921. eCollection 2014. PubMed |
| Capsaicin treatment attenuates cholangiocarcinoma carcinogenesis. Wutka A, Palagani V, Barat S, Chen X, El Khatib M, Gotze J, Belahmer H, Zender S, Bozko P, Malek NP, Plentz RR. PLoS One. 2014 Apr 18;9(4):e95605. doi: 10.1371/journal.pone.0095605. eCollection 2014. PubMed |
AP1S3 mutations are associated with pustular psoriasis and impaired Toll-like receptor 3 trafficking.
Setta-Kaffetzi N, Simpson MA, Navarini AA, Patel VM, Lu HC, Allen MH, Duckworth M, Bachelez H, Burden AD, Choon SE, Griffiths CE, Kirby B, Kolios A, Seyger MM, Prins C, Smahi A, Trembath RC, Fraternali F, Smith CH, Barker JN, Capon F.
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| Human papillomavirus 16 E6 contributes HIF-1alpha induced Warburg effect by attenuating the VHL-HIF-1alpha interaction. Guo Y, Meng X, Ma J, Zheng Y, Wang Q, Wang Y, Shang H. Int J Mol Sci. 2014 May 7;15(5):7974-86. doi: 10.3390/ijms15057974. PubMed |
| Cooperation of tyrosine kinase receptor TrkB and epidermal growth factor receptor signaling enhances migration and dispersal of lung tumor cells. Gotz R, Sendtner M. PLoS One. 2014 Jun 24;9(6):e100944. doi: 10.1371/journal.pone.0100944. eCollection 2014. PubMed |
Spatiotemporal control of fibroblast growth factor receptor signals by blue light.
Kim N, Kim JM, Lee M, Kim CY, Chang KY, Heo WD.
Chem Biol. 2014 Jul 17;21(7):903-12. doi: 10.1016/j.chembiol.2014.05.013. Epub 2014 Jun 26.
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| Dissecting engineered cell types and enhancing cell fate conversion via CellNet. Morris SA, Cahan P, Li H, Zhao AM, San Roman AK, Shivdasani RA, Collins JJ, Daley GQ. Cell. 2014 Aug 14;158(4):889-902. doi: 10.1016/j.cell.2014.07.021. PubMed |
| Complementation for an essential ancillary non-structural protein function across parvovirus genera. Mihaylov IS, Cotmore SF, Tattersall P. Virology. 2014 Nov;468-470:226-37. doi: 10.1016/j.virol.2014.07.043. Epub 2014 Sep 6. PubMed |
| Kruppel-like factor 6 interferes with cellular transformation induced by the H-ras oncogene. Trucco LD, Andreoli V, Nunez NG, Maccioni M, Bocco JL. FASEB J. 2014 Dec;28(12):5262-76. doi: 10.1096/fj.14-251884. Epub 2014 Sep 11. PubMed |
| PDGF-D expression is down-regulated by TGFbeta in fibroblasts. Charni Chaabane S, Coomans de Brachene A, Essaghir A, Velghe A, Lo Re S, Stockis J, Lucas S, Khachigian LM, Huaux F, Demoulin JB. PLoS One. 2014 Oct 3;9(10):e108656. doi: 10.1371/journal.pone.0108656. eCollection 2014. PubMed |
| The novel organic arsenical darinaparsin induces MAPK-mediated and SHP1-dependent cell death in T-cell lymphoma and Hodgkin lymphoma cells and human xenograft models. Ravi D, Bhalla S, Gartenhaus RB, Crombie J, Kandela I, Sharma J, Mazar A, Evens AM. Clin Cancer Res. 2014 Dec 1;20(23):6023-33. doi: 10.1158/1078-0432.CCR-14-1532. Epub 2014 Oct 14. PubMed |
A platform for rapid prototyping of synthetic gene networks in mammalian cells.
Duportet X, Wroblewska L, Guye P, Li Y, Eyquem J, Rieders J, Rimchala T, Batt G, Weiss R.
Nucleic Acids Res. 2014 Dec 1;42(21):13440-51. doi: 10.1093/nar/gku1082. Epub 2014 Nov 5.
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| Generation and Neuronal Differentiation of Patient-Specific Induced Pluripotent Stem Cells Derived from Niemann-Pick Type C1 Fibroblasts. Trilck M, Hubner R, Frech MJ. Methods Mol Biol. 2014 Dec 18. PubMed |
| Targeting the effector domain of the myristoylated alanine rich C-kinase substrate enhances lung cancer radiation sensitivity. Rohrbach TD, Jarboe JS, Anderson JC, Trummell HQ, Hicks PH, Weaver AN, Yang ES, Oster RA, Deshane JS, Steele C, Siegal GP, Bonner JA, Willey CD. Int J Oncol. 2015 Mar;46(3):1079-88. doi: 10.3892/ijo.2014.2799. Epub 2014 Dec 17. PubMed |
| Progerin expression disrupts critical adult stem cell functions involved in tissue repair. Pacheco LM, Gomez LA, Dias J, Ziebarth NM, Howard GA, Schiller PC. Aging (Albany NY). 2014 Dec;6(12):1049-63. PubMed |
| ANKS6 is the critical activator of NEK8 kinase in embryonic situs determination and organ patterning. Czarnecki PG, Gabriel GC, Manning DK, Sergeev M, Lemke K, Klena NT, Liu X, Chen Y, Li Y, San Agustin JT, Garnaas MK, Francis RJ, Tobita K, Goessling W, Pazour GJ, Lo CW, Beier DR, Shah JV. Nat Commun. 2015 Jan 20;6:6023. doi: 10.1038/ncomms7023. PubMed |
| Alternative splicing regulates the expression of G9A and SUV39H2 methyltransferases, and dramatically changes SUV39H2 functions. Mauger O, Klinck R, Chabot B, Muchardt C, Allemand E, Batsche E. Nucleic Acids Res. 2015 Feb 18;43(3):1869-82. doi: 10.1093/nar/gkv013. Epub 2015 Jan 20. PubMed |
| DNA damage response factors from diverse pathways, including DNA crosslink repair, mediate alternative end joining. Howard SM, Yanez DA, Stark JM. PLoS Genet. 2015 Jan 28;11(1):e1004943. doi: 10.1371/journal.pgen.1004943. eCollection 2015 Jan. PubMed |
| F-actin bundles direct the initiation and orientation of lamellipodia through adhesion-based signaling. Johnson HE, King SJ, Asokan SB, Rotty JD, Bear JE, Haugh JM. J Cell Biol. 2015 Feb 16;208(4):443-55. doi: 10.1083/jcb.201406102. Epub 2015 Feb 9. PubMed |
| Innate immune response to Streptococcus pyogenes depends on the combined activation of TLR13 and TLR2. Fieber C, Janos M, Koestler T, Gratz N, Li XD, Castiglia V, Aberle M, Sauert M, Wegner M, Alexopoulou L, Kirschning CJ, Chen ZJ, von Haeseler A, Kovarik P. PLoS One. 2015 Mar 10;10(3):e0119727. doi: 10.1371/journal.pone.0119727. eCollection 2015. PubMed |
| RSPO2 Enhances Canonical Wnt Signaling to Confer Stemness-Associated Traits to Susceptible Pancreatic Cancer Cells. Ilmer M, Boiles AR, Regel I, Yokoi K, Michalski CW, Wistuba II, Rodriguez J, Alt E, Vykoukal J. Cancer Res. 2015 May 1;75(9):1883-96. doi: 10.1158/0008-5472.CAN-14-1327. Epub 2015 Mar 13. PubMed |
| A Proteomic Strategy Identifies Lysine Methylation of Splicing Factor snRNP70 by the SETMAR Enzyme. Carlson SM, Moore KE, Sankaran SM, Reynoird N, Elias JE, Gozani O. J Biol Chem. 2015 May 8;290(19):12040-7. doi: 10.1074/jbc.M115.641530. Epub 2015 Mar 20. PubMed |
| Loss of TGFbeta Receptor Type 2 Expression Impairs Estrogen Response and Confers Tamoxifen Resistance. Busch S, Sims AH, Stal O, Ferno M, Landberg G. Cancer Res. 2015 Apr 1;75(7):1457-69. doi: 10.1158/0008-5472.CAN-14-1583. PubMed |
| Proteasome inhibition enhances the killing effect of BikDD gene therapy. Sun Y, Ponz-Sarvise M, Chang SS, Chang WC, Chen CH, Hsu JL, Hung MC. Am J Transl Res. 2015 Feb 15;7(2):319-27. eCollection 2015. PubMed |
| Transglutaminase Is Required for Epidermal Squamous Cell Carcinoma Stem Cell Survival. Fisher ML, Keillor JW, Xu W, Eckert RL, Kerr C. Mol Cancer Res. 2015 Jul;13(7):1083-94. doi: 10.1158/1541-7786.MCR-14-0685-T. Epub 2015 May 1. PubMed |
| Type II transglutaminase stimulates epidermal cancer stem cell epithelial-mesenchymal transition. Fisher ML, Adhikary G, Xu W, Kerr C, Keillor JW, Eckert RL. Oncotarget. 2015 Aug 21;6(24):20525-39. PubMed |
| MALT1 is required for EGFR-induced NF-kappaB activation and contributes to EGFR-driven lung cancer progression. Pan D, Jiang C, Ma Z, Blonska M, You MJ, Lin X. Oncogene. 2015 May 18. doi: 10.1038/onc.2015.146. PubMed |
TRAFD1 (FLN29) Interacts with Plekhm1 and Regulates Osteoclast Acidification and Resorption.
Witwicka H, Jia H, Kutikov A, Reyes-Gutierrez P, Li X, Odgren PR.
PLoS One. 2015 May 19;10(5):e0127537. doi: 10.1371/journal.pone.0127537. eCollection 2015.
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| Cardiospecific CD36 suppression by lentivirus-mediated RNA interference prevents cardiac hypertrophy and systolic dysfunction in high-fat-diet induced obese mice. Zhang Y, Bao M, Dai M, Wang X, He W, Tan T, Lin D, Wang W, Wen Y, Zhang R. Cardiovasc Diabetol. 2015 Jun 3;14:69. doi: 10.1186/s12933-015-0234-z. PubMed |
| Tumors escape CD4+ T cell-mediated immunosurveillance by impairing the ability of infiltrating macrophages to indirectly present tumor antigens. Tveita AA, Schjesvold F, Haabeth OA, Fauskanger MH, Bogen B. Cancer Res. 2015 Jun 2. pii: canres.3640.2014. PubMed |
| CRISPR-Cas9-mediated gene knockout in primary human airway epithelial cells reveals a proinflammatory role for MUC18. Chu HW, Rios C, Huang C, Wesolowska-Andersen A, Burchard EG, O'Connor BP, Fingerlin TE, Nichols D, Reynolds SD, Seibold MA. Gene Ther. 2015 Jul 2. doi: 10.1038/gt.2015.53. PubMed |
| MYBL2 guides autophagy suppressor VDAC2 in the developing ovary to inhibit autophagy through a complex of VDAC2-BECN1-BCL2L1 in mammals. Yuan J, Zhang Y, Sheng Y, Fu X, Cheng H, Zhou R. Autophagy. 2015;11(7):1081-98. doi: 10.1080/15548627.2015.1040970. PubMed |
| More Tricks with Tetramers: A Practical Guide to Staining T cells with peptide-MHC Multimers. Dolton G, Tungatt K, Lloyd A, Bianchi V, Theaker SM, Trimby A, Holland CJ, Donia M, Godkin AJ, Cole DK, Straten PT, Peakman M, Svane IM, Sewell AK. Immunology. 2015 Jun 16. doi: 10.1111/imm.12499. PubMed |
| Dynamic Changes in Cytosolic ATP Levels in Cultured Glutamatergic Neurons During NMDA-Induced Synaptic Activity Supported by Glucose or Lactate. Lange SC, Winkler U, Andresen L, Byhro M, Waagepetersen HS, Hirrlinger J, Bak LK. Neurochem Res. 2015 Dec;40(12):2517-26. doi: 10.1007/s11064-015-1651-9. Epub 2015 Jul 17. PubMed |
| A Novel Role of E-Cadherin-Based Adherens Junctions in Neoplastic Cell Dissemination. Rubtsova SN, Zhitnyak IY, Gloushankova NA. PLoS One. 2015 Jul 24;10(7):e0133578. doi: 10.1371/journal.pone.0133578. eCollection 2015. PubMed |
| Heat shock factor 1 induces cancer stem cell phenotype in breast cancer cell lines. Wang B, Lee CW, Witt A, Thakkar A, Ince TA. Breast Cancer Res Treat. 2015 Aug;153(1):57-66. doi: 10.1007/s10549-015-3521-1. Epub 2015 Jul 30. PubMed |
Mammalian synthetic circuits with RNA binding proteins for RNA-only delivery.
Wroblewska L, Kitada T, Endo K, Siciliano V, Stillo B, Saito H, Weiss R.
Nat Biotechnol. 2015 Aug 3. doi: 10.1038/nbt.3301.
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Associated Plasmids |
Improvement of HIV-1 and Human T Cell Lymphotropic Virus Type 1 Replication-Dependent Vectors via Optimization of Reporter Gene Reconstitution and Modification with Intronic Short Hairpin RNA.
Shunaeva A, Potashnikova D, Pichugin A, Mishina A, Filatov A, Nikolaitchik O, Hu WS, Mazurov D.
J Virol. 2015 Oct 15;89(20):10591-601. doi: 10.1128/JVI.01940-15. Epub 2015 Aug 12.
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| hVGAT-mCherry: A novel molecular tool for analysis of GABAergic neurons derived from human pluripotent stem cells. DeRosa BA, Belle KC, Thomas BJ, Cukier HN, Pericak-Vance MA, Vance JM, Dykxhoorn DM. Mol Cell Neurosci. 2015 Sep;68:244-57. doi: 10.1016/j.mcn.2015.08.007. Epub 2015 Aug 16. PubMed |
| Retroviral Transduction of T Cells and T Cell Precursors. Simmons A, Alberola-Ila J. Methods Mol Biol. 2016;1323:99-108. doi: 10.1007/978-1-4939-2809-5_8. PubMed |
| Inhibition of adipose triglyceride lipase (ATGL) by the putative tumor suppressor G0S2 or a small molecule inhibitor attenuates the growth of cancer cells. Zagani R, El-Assaad W, Gamache I, Teodoro JG. Oncotarget. 2015 Sep 29;6(29):28282-95. doi: 10.18632/oncotarget.5061. PubMed |
| Derivation of LIF-independent mouse iPS cells with modified Oct4. Hirai H, Firpo M, Kikyo N. Stem Cell Res. 2015 Sep;15(2):384-6. doi: 10.1016/j.scr.2015.08.005. Epub 2015 Aug 17. PubMed |
Identification of an oncogenic RAB protein.
Wheeler DB, Zoncu R, Root DE, Sabatini DM, Sawyers CL.
Science. 2015 Oct 9;350(6257):211-7. doi: 10.1126/science.aaa4903. Epub 2015 Sep 3.
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| Use of genetically-encoded calcium indicators for live cell calcium imaging and localization in virus-infected cells. Perry JL, Ramachandran NK, Utama B, Hyser JM. Methods. 2015 Nov 15;90:28-38. doi: 10.1016/j.ymeth.2015.09.004. Epub 2015 Sep 3. PubMed |
| The Deleted in Liver Cancer 1 (Dlc1) tumor suppressor is haploinsufficient for mammary gland development and epithelial cell polarity. Basak P, Dillon R, Leslie H, Raouf A, Mowat MR. BMC Cancer. 2015 Sep 9;15:630. doi: 10.1186/s12885-015-1642-x. PubMed |
| CRISPR/Cas9 System as an Agent for Eliminating Polyomavirus JC Infection. Wollebo HS, Bellizzi A, Kaminski R, Hu W, White MK, Khalili K. PLoS One. 2015 Sep 11;10(9):e0136046. doi: 10.1371/journal.pone.0136046. eCollection 2015. PubMed |
| Expression profiling of in vivo ductal carcinoma in situ progression models identified B cell lymphoma-9 as a molecular driver of breast cancer invasion. Elsarraj HS, Hong Y, Valdez KE, Michaels W, Hook M, Smith WP, Chien J, Herschkowitz JI, Troester MA, Beck M, Inciardi M, Gatewood J, May L, Cusick T, McGinness M, Ricci L, Fan F, Tawfik O, Marks JR, Knapp JR, Yeh HW, Thomas P, Carrasco DR, Fields TA, Godwin AK, Behbod F. Breast Cancer Res. 2015 Sep 17;17:128. doi: 10.1186/s13058-015-0630-z. PubMed |
| SLUG is required for SOX9 stabilization and functions to promote cancer stem cells and metastasis in human lung carcinoma. Luanpitpong S, Li J, Manke A, Brundage K, Ellis E, McLaughlin SL, Angsutararux P, Chanthra N, Voronkova M, Chen YC, Wang L, Chanvorachote P, Pei M, Issaragrisil S, Rojanasakul Y. Oncogene. 2015 Sep 21. doi: 10.1038/onc.2015.351. PubMed |
| Histone Deacetylase 3 Coordinates Deacetylase-independent Epigenetic Silencing of Transforming Growth Factor-beta1 (TGF-beta1) to Orchestrate Second Heart Field Development. Lewandowski SL, Janardhan HP, Trivedi CM. J Biol Chem. 2015 Nov 6;290(45):27067-89. doi: 10.1074/jbc.M115.684753. Epub 2015 Sep 29. PubMed |
| ZIC2-dependent OCT4 activation drives self-renewal of human liver cancer stem cells. Zhu P, Wang Y, He L, Huang G, Du Y, Zhang G, Yan X, Xia P, Ye B, Wang S, Hao L, Wu J, Fan Z. J Clin Invest. 2015 Oct 1;125(10):3795-808. doi: 10.1172/JCI81979. Epub 2015 Aug 31. PubMed |
| MCL-1-independent mechanisms of synergy between dual PI3K/mTOR and BCL-2 inhibition in diffuse large B cell lymphoma. Lee JS, Tang SS, Ortiz V, Vo TT, Fruman DA. Oncotarget. 2015 Nov 3;6(34):35202-17. doi: 10.18632/oncotarget.6051. PubMed |
| The Effector Domain of MARCKS Is a Nuclear Localization Signal that Regulates Cellular PIP2 Levels and Nuclear PIP2 Localization. Rohrbach TD, Shah N, Jackson WP, Feeney EV, Scanlon S, Gish R, Khodadadi R, Hyde SO, Hicks PH, Anderson JC, Jarboe JS, Willey CD. PLoS One. 2015 Oct 15;10(10):e0140870. doi: 10.1371/journal.pone.0140870. eCollection 2015. PubMed |
| NRF2 regulates serine biosynthesis in non-small cell lung cancer. DeNicola GM, Chen PH, Mullarky E, Sudderth JA, Hu Z, Wu D, Tang H, Xie Y, Asara JM, Huffman KE, Wistuba II, Minna JD, DeBerardinis RJ, Cantley LC. Nat Genet. 2015 Dec;47(12):1475-81. doi: 10.1038/ng.3421. Epub 2015 Oct 19. PubMed |
| Inducing Pluripotency in Cattle. Malaver-Ortega LF, Taheri-Ghahfarokhi A, Sumer H. Methods Mol Biol. 2015;1330:57-68. doi: 10.1007/978-1-4939-2848-4_6. PubMed |
| A PCR-Based Method to Construct Lentiviral Vector Expressing Double Tough Decoy for miRNA Inhibition. Qiu H, Zhong J, Luo L, Liu N, Kang K, Qu J, Peng W, Gou D. PLoS One. 2015 Dec 1;10(12):e0143864. doi: 10.1371/journal.pone.0143864. eCollection 2015. PubMed |
| A new design of a lentiviral shRNA vector with inducible co-expression of ARGONAUTE 2 for enhancing gene silencing efficiency. He J, Huang L, Qiu H, Li J, Luo L, Li Y, Tian S, Kang K, Luo J, Liu L, Gou D. Cell Biosci. 2015 Dec 8;5:67. doi: 10.1186/s13578-015-0058-2. eCollection 2015. PubMed |
| Long-acting cocaine hydrolase for addiction therapy. Chen X, Xue L, Hou S, Jin Z, Zhang T, Zheng F, Zhan CG. Proc Natl Acad Sci U S A. 2016 Jan 12;113(2):422-7. doi: 10.1073/pnas.1517713113. Epub 2015 Dec 28. PubMed |
| Sphingosine kinase 1 is required for TGF-beta mediated fibroblastto- myofibroblast differentiation in ovarian cancer. Beach JA, Aspuria PJ, Cheon DJ, Lawrenson K, Agadjanian H, Walsh CS, Karlan BY, Orsulic S. Oncotarget. 2016 Jan 26;7(4):4167-82. doi: 10.18632/oncotarget.6703. PubMed |
| Genetically engineering self-organization of human pluripotent stem cells into a liver bud-like tissue using Gata6. Guye P, Ebrahimkhani MR, Kipniss N, Velazquez JJ, Schoenfeld E, Kiani S, Griffith LG, Weiss R. Nat Commun. 2016 Jan 6;7:10243. doi: 10.1038/ncomms10243. PubMed |
| Human iPS cell model of type 3 long QT syndrome recapitulates drug-based phenotype correction. Malan D, Zhang M, Stallmeyer B, Muller J, Fleischmann BK, Schulze-Bahr E, Sasse P, Greber B. Basic Res Cardiol. 2016 Mar;111(2):14. doi: 10.1007/s00395-016-0530-0. Epub 2016 Jan 23. PubMed |
| Opposing Roles of JNK and p38 in Lymphangiogenesis in Melanoma. Puujalka E, Heinz M, Hoesel B, Friedl P, Schweighofer B, Wenzina J, Pirker C, Schmid JA, Loewe R, Wagner EF, Berger W, Petzelbauer P. J Invest Dermatol. 2016 May;136(5):967-77. doi: 10.1016/j.jid.2016.01.020. Epub 2016 Jan 30. PubMed |
| Characterization of Two-Pore Channel 2 by Nuclear Membrane Electrophysiology. Lee CS, Tong BC, Cheng CW, Hung HC, Cheung KH. Sci Rep. 2016 Feb 3;6:20282. doi: 10.1038/srep20282. PubMed |
| Inhibition of JAK-STAT ERK/MAPK and Glycogen Synthase Kinase-3 Induces a Change in Gene Expression Profile of Bovine Induced Pluripotent Stem Cells. Malaver-Ortega LF, Sumer H, Liu J, Verma PJ. Stem Cells Int. 2016;2016:5127984. doi: 10.1155/2016/5127984. Epub 2016 Jan 6. PubMed |
| Iron induces cancer stem cells and aggressive phenotypes in human lung cancer cells. Chanvorachote P, Luanpitpong S. Am J Physiol Cell Physiol. 2016 May 1;310(9):C728-39. doi: 10.1152/ajpcell.00322.2015. Epub 2016 Feb 24. PubMed |
| Phosphorylation-Dependent Regulation of the DNA Damage Response of Adaptor Protein KIBRA in Cancer Cells. Mavuluri J, Beesetti S, Surabhi R, Kremerskothen J, Venkatraman G, Rayala SK. Mol Cell Biol. 2016 Apr 15;36(9):1354-65. doi: 10.1128/MCB.01004-15. Print 2016 May 1. PubMed |
| The retrovirus HTLV-1 inserts an ectopic CTCF-binding site into the human genome. Satou Y, Miyazato P, Ishihara K, Yaguchi H, Melamed A, Miura M, Fukuda A, Nosaka K, Watanabe T, Rowan AG, Nakao M, Bangham CR. Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):3054-9. doi: 10.1073/pnas.1423199113. Epub 2016 Feb 29. PubMed |
| Inhibition of Focal Adhesion Kinase Signaling by Integrin alpha6beta1 Supports Human Pluripotent Stem Cell Self-Renewal. Villa-Diaz LG, Kim JK, Laperle A, Palecek SP, Krebsbach PH. Stem Cells. 2016 Jul;34(7):1753-64. doi: 10.1002/stem.2349. Epub 2016 Mar 27. PubMed |
| Viral Packaging and Cell Culture for CRISPR-Based Screens. Wang T, Lander ES, Sabatini DM. Cold Spring Harb Protoc. 2016 Mar 1;2016(3):pdb.prot090811. doi: 10.1101/pdb.prot090811. PubMed |
| Editing of mouse and human immunoglobulin genes by CRISPR-Cas9 system. Cheong TC, Compagno M, Chiarle R. Nat Commun. 2016 Mar 9;7:10934. doi: 10.1038/ncomms10934. PubMed |
| Deacetylation Assays to Unravel the Interplay between Sirtuins (SIRT2) and Specific Protein-substrates. Song HY, Park SH, Kang HJ, Vassilopoulos A. J Vis Exp. 2016 Feb 27;(108). doi: 10.3791/53563. PubMed |
| Activation of individual L1 retrotransposon instances is restricted to cell-type dependent permissive loci. Philippe C, Vargas-Landin DB, Doucet AJ, van Essen D, Vera-Otarola J, Kuciak M, Corbin A, Nigumann P, Cristofari G. Elife. 2016 Mar 26;5. pii: e13926. doi: 10.7554/eLife.13926. PubMed |
| Control of glioblastoma tumorigenesis by feed-forward cytokine signaling. Jahani-Asl A, Yin H, Soleimani VD, Haque T, Luchman HA, Chang NC, Sincennes MC, Puram SV, Scott AM, Lorimer IA, Perkins TJ, Ligon KL, Weiss S, Rudnicki MA, Bonni A. Nat Neurosci. 2016 Jun;19(6):798-806. doi: 10.1038/nn.4295. Epub 2016 Apr 25. PubMed |
| An essential role for Grk2 in Hedgehog signalling downstream of Smoothened. Zhao Z, Lee RT, Pusapati GV, Iyu A, Rohatgi R, Ingham PW. EMBO Rep. 2016 May;17(5):739-52. doi: 10.15252/embr.201541532. Epub 2016 Apr 4. PubMed |
| The mitochondrial calcium uniporter regulates breast cancer progression via HIF-1alpha. Tosatto A, Sommaggio R, Kummerow C, Bentham RB, Blacker TS, Berecz T, Duchen MR, Rosato A, Bogeski I, Szabadkai G, Rizzuto R, Mammucari C. EMBO Mol Med. 2016 May 2;8(5):569-85. doi: 10.15252/emmm.201606255. PubMed |
| Analysis of Nuclear Lamina Proteins in Myoblast Differentiation by Functional Complementation. Tapia O, Gerace L. Methods Mol Biol. 2016;1411:177-94. doi: 10.1007/978-1-4939-3530-7_11. PubMed |
| Engineering and Functional Analysis of Mitotic Kinases Through Chemical Genetics. Jones MJ, Jallepalli PV. Methods Mol Biol. 2016;1413:349-63. doi: 10.1007/978-1-4939-3542-0_22. PubMed |
| Interferon-induced sterile alpha motif and histidine/aspartic acid domain-containing protein 1 expression in astrocytes and microglia is mediated by microRNA-181a. Jin C, Peng X, Liu F, Cheng L, Xie T, Lu X, Wu H, Wu N. AIDS. 2016 Aug 24;30(13):2053-64. doi: 10.1097/QAD.0000000000001166. PubMed |
| Measuring IL-1beta Processing by Bioluminescence Sensors II: The iGLuc System. Bartok E, Kampes M, Hornung V. Methods Mol Biol. 2016;1417:97-113. doi: 10.1007/978-1-4939-3566-6_6. PubMed |
| Integrin alphavbeta3 enhances beta-catenin signaling in acute myeloid leukemia harboring Fms-like tyrosine kinase-3 internal tandem duplication mutations: implications for microenvironment influence on sorafenib sensitivity. Yi H, Zeng D, Shen Z, Liao J, Wang X, Liu Y, Zhang X, Kong P. Oncotarget. 2016 Jun 28;7(26):40387-40397. doi: 10.18632/oncotarget.9617. PubMed |
| Autocrine Complement Inhibits IL10-Dependent T-Cell Mediated Antitumor Immunity to Promote Tumor Progression. Wang Y, Sun SN, Liu Q, Yu YY, Guo J, Wang K, Xing BC, Zheng QF, Campa MJ, Patz EF, Li SY, He YW. Cancer Discov. 2016 Jun 13. pii: CD-15-1412. PubMed |
| MicroRNA-17-92 regulates myoblast proliferation and differentiation by targeting the ENH1/Id1 signaling axis. Qiu H, Liu N, Luo L, Zhong J, Tang Z, Kang K, Qu J, Peng W, Liu L, Li L, Gou D. Cell Death Differ. 2016 Jun 17. doi: 10.1038/cdd.2016.56. PubMed |
| YPEL4 modulates HAC15 adrenal cell proliferation and is associated with tumor diameter. Oki K, Plonczynski MW, Gomez-Sanchez EP, Gomez-Sanchez CE. Mol Cell Endocrinol. 2016 Oct 15;434:93-8. doi: 10.1016/j.mce.2016.06.022. Epub 2016 Jun 19. PubMed |
| RNAi-mediated silencing of HLA A2 suppressed acute rejection against human fibroblast xenografts in the striatum of 6-OHDA lesioned rats. Liang C, Xu Y, Zheng D, Sun X, Xu Q, Duan D. J Neuroimmunol. 2016 Aug 15;297:28-37. doi: 10.1016/j.jneuroim.2016.05.002. Epub 2016 May 3. PubMed |
| Role of SUMO activating enzyme in cancer stem cell maintenance and self-renewal. Du L, Li YJ, Fakih M, Wiatrek RL, Duldulao M, Chen Z, Chu P, Garcia-Aguilar J, Chen Y. Nat Commun. 2016 Jul 28;7:12326. doi: 10.1038/ncomms12326. PubMed |
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| SYK Inhibition Induces Apoptosis in Germinal Center-Like B Cells by Modulating the Antiapoptotic Protein Myeloid Cell Leukemia-1, Affecting B-Cell Activation and Antibody Production. Roders N, Herr F, Ambroise G, Thaunat O, Portier A, Vazquez A, Durrbach A. Front Immunol. 2018 Apr 24;9:787. doi: 10.3389/fimmu.2018.00787. eCollection 2018. PubMed |
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| The Epigenetic State of PRDM16-Regulated Enhancers in Radial Glia Controls Cortical Neuron Position. Baizabal JM, Mistry M, Garcia MT, Gomez N, Olukoya O, Tran D, Johnson MB, Walsh CA, Harwell CC. Neuron. 2018 Jun 6;98(5):945-962.e8. doi: 10.1016/j.neuron.2018.04.033. Epub 2018 May 17. PubMed |
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| Vpr Targets TET2 for Degradation by CRL4(VprBP) E3 Ligase to Sustain IL-6 Expression and Enhance HIV-1 Replication. Lv L, Wang Q, Xu Y, Tsao LC, Nakagawa T, Guo H, Su L, Xiong Y. Mol Cell. 2018 Jun 7;70(5):961-970.e5. doi: 10.1016/j.molcel.2018.05.007. Epub 2018 Jun 7. PubMed |
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| Regulation of miR-34b/c-targeted gene expression program by SUMOylation. Li YJ, Du L, Aldana-Masangkay G, Wang X, Urak R, Forman SJ, Rosen ST, Chen Y. Nucleic Acids Res. 2018 Aug 21;46(14):7108-7123. doi: 10.1093/nar/gky484. PubMed |
| Knockout of USP19 Deubiquitinating Enzyme Prevents Muscle Wasting by Modulating Insulin and Glucocorticoid Signaling. Coyne ES, Bedard N, Wykes L, Stretch C, Jammoul S, Li S, Zhang K, Sladek RS, Bathe OF, Jagoe RT, Posner BI, Wing SS. Endocrinology. 2018 Aug 1;159(8):2966-2977. doi: 10.1210/en.2018-00290. PubMed |
| Telomerase reverse transcriptase coordinates with the epithelial-to-mesenchymal transition through a feedback loop to define properties of breast cancer stem cells. El-Badawy A, Ghoneim NI, Nasr MA, Elkhenany H, Ahmed TA, Ahmed SM, El-Badri N. Biol Open. 2018 Jul 25;7(7). pii: bio.034181. doi: 10.1242/bio.034181. PubMed |
A Rapid and Precise Mutation-Activated Fluorescence Reporter for Analyzing Acute Mutagenesis Frequency.
Birnbaum MD, Nemzow L, Kumar A, Gong F, Zhang F.
Cell Chem Biol. 2018 Aug 16;25(8):1038-1049.e5. doi: 10.1016/j.chembiol.2018.05.010. Epub 2018 Jun 14.
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| CAPTURE: In Situ Analysis of Chromatin Composition of Endogenous Genomic Loci by Biotinylated dCas9. Liu X, Zhang Y, Chen Y, Li M, Shao Z, Zhang MQ, Xu J. Curr Protoc Mol Biol. 2018 Jul;123(1):e64. doi: 10.1002/cpmb.64. Epub 2018 Jun 19. PubMed |
| Identification, characterization and application of a new peptide against anterior gradient homolog 2 (AGR2). Garri C, Howell S, Tiemann K, Tiffany A, Jalali-Yazdi F, Alba MM, Katz JE, Takahashi TT, Landgraf R, Gross ME, Roberts RW, Kani K. Oncotarget. 2018 Jun 8;9(44):27363-27379. doi: 10.18632/oncotarget.25221. eCollection 2018 Jun 8. PubMed |
| Generation of Luciferase-expressing Tumor Cell Lines. Brennan TV, Lin L, Huang X, Yang Y. Bio Protoc. 2018 Apr 20;8(8). doi: 10.21769/BioProtoc.2817. PubMed |
| A versatile lentiviral delivery toolkit for proximity-dependent biotinylation in diverse cell types. Samavarchi-Tehrani P, Abdouni H, Samson R, Gingras AC. Mol Cell Proteomics. 2018 Jul 10. pii: TIR118.000902. doi: 10.1074/mcp.TIR118.000902. PubMed |
| WDR41 supports lysosomal response to changes in amino acid availability. Amick J, Tharkeshwar AK, Amaya C, Ferguson SM. Mol Biol Cell. 2018 Sep 1;29(18):2213-2227. doi: 10.1091/mbc.E17-12-0703. Epub 2018 Jul 11. PubMed |
| Mitochondrial Stasis Reveals p62-Mediated Ubiquitination in Parkin-Independent Mitophagy and Mitigates Nonalcoholic Fatty Liver Disease. Yamada T, Murata D, Adachi Y, Itoh K, Kameoka S, Igarashi A, Kato T, Araki Y, Huganir RL, Dawson TM, Yanagawa T, Okamoto K, Iijima M, Sesaki H. Cell Metab. 2018 Oct 2;28(4):588-604.e5. doi: 10.1016/j.cmet.2018.06.014. Epub 2018 Jul 12. PubMed |
| Detection of Succinate by Intestinal Tuft Cells Triggers a Type 2 Innate Immune Circuit. Nadjsombati MS, McGinty JW, Lyons-Cohen MR, Jaffe JB, DiPeso L, Schneider C, Miller CN, Pollack JL, Nagana Gowda GA, Fontana MF, Erle DJ, Anderson MS, Locksley RM, Raftery D, von Moltke J. Immunity. 2018 Jul 17;49(1):33-41.e7. doi: 10.1016/j.immuni.2018.06.016. PubMed |
| Translational Control through Differential Ribosome Pausing during Amino Acid Limitation in Mammalian Cells. Darnell AM, Subramaniam AR, O'Shea EK. Mol Cell. 2018 Jul 19;71(2):229-243.e11. doi: 10.1016/j.molcel.2018.06.041. PubMed |
Mitochondrial inner membrane permeabilisation enables mtDNA release during apoptosis.
Riley JS, Quarato G, Cloix C, Lopez J, O'Prey J, Pearson M, Chapman J, Sesaki H, Carlin LM, Passos JF, Wheeler AP, Oberst A, Ryan KM, Tait SW.
EMBO J. 2018 Sep 3;37(17). pii: embj.201899238. doi: 10.15252/embj.201899238. Epub 2018 Jul 26.
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| Regulation of the adaptation to ER stress by KLF4 facilitates melanoma cell metastasis via upregulating NUCB2 expression. Zhang D, Lin J, Chao Y, Zhang L, Jin L, Li N, He R, Ma B, Zhao W, Han C. J Exp Clin Cancer Res. 2018 Jul 28;37(1):176. doi: 10.1186/s13046-018-0842-z. PubMed |
| Entry Inhibition and Modulation of Pro-Inflammatory Immune Response Against Influenza A Virus by a Recombinant Truncated Surfactant Protein D. Al-Ahdal MN, Murugaiah V, Varghese PM, Abozaid SM, Saba I, Al-Qahtani AA, Pathan AA, Kouser L, Nal B, Kishore U. Front Immunol. 2018 Jul 30;9:1586. doi: 10.3389/fimmu.2018.01586. eCollection 2018. PubMed |
| Signatures of T cell dysfunction and exclusion predict cancer immunotherapy response. Jiang P, Gu S, Pan D, Fu J, Sahu A, Hu X, Li Z, Traugh N, Bu X, Li B, Liu J, Freeman GJ, Brown MA, Wucherpfennig KW, Liu XS. Nat Med. 2018 Oct;24(10):1550-1558. doi: 10.1038/s41591-018-0136-1. Epub 2018 Aug 20. PubMed |
| Dppa2/4 Facilitate Epigenetic Remodeling during Reprogramming to Pluripotency. Hernandez C, Wang Z, Ramazanov B, Tang Y, Mehta S, Dambrot C, Lee YW, Tessema K, Kumar I, Astudillo M, Neubert TA, Guo S, Ivanova NB. Cell Stem Cell. 2018 Sep 6;23(3):396-411.e8. doi: 10.1016/j.stem.2018.08.001. Epub 2018 Aug 23. PubMed |
| SHLD2/FAM35A co-operates with REV7 to coordinate DNA double-strand break repair pathway choice. Findlay S, Heath J, Luo VM, Malina A, Morin T, Coulombe Y, Djerir B, Li Z, Samiei A, Simo-Cheyou E, Karam M, Bagci H, Rahat D, Grapton D, Lavoie EG, Dove C, Khaled H, Kuasne H, Mann KK, Klein KO, Greenwood CM, Tabach Y, Park M, Cote JF, Masson JY, Marechal A, Orthwein A. EMBO J. 2018 Sep 14;37(18). pii: embj.2018100158. doi: 10.15252/embj.2018100158. Epub 2018 Aug 28. PubMed |
| Tbx1 represses Mef2c gene expression and is correlated with histone 3 deacetylation of the anterior heart field enhancer. Pane LS, Fulcoli FG, Cirino A, Altomonte A, Ferrentino R, Bilio M, Baldini A. Dis Model Mech. 2018 Aug 30;11(9). pii: 11/9/dmm029967. doi: 10.1242/dmm.029967. PubMed |
| KLF4, a miR-32-5p targeted gene, promotes cisplatin-induced apoptosis by upregulating BIK expression in prostate cancer. Zhang L, Li X, Chao Y, He R, Liu J, Yuan Y, Zhao W, Han C, Song X. Cell Commun Signal. 2018 Sep 3;16(1):53. doi: 10.1186/s12964-018-0270-x. PubMed |
| The cargo receptor SURF4 promotes the efficient cellular secretion of PCSK9. Emmer BT, Hesketh GG, Kotnik E, Tang VT, Lascuna PJ, Xiang J, Gingras AC, Chen XW, Ginsburg D. Elife. 2018 Sep 25;7. pii: 38839. doi: 10.7554/eLife.38839. PubMed |
| Reactive oxygen species mediate cancer stem-like cells and determine bortezomib sensitivity via Mcl-1 and Zeb-1 in mantle cell lymphoma. Luanpitpong S, Poohadsuan J, Samart P, Kiratipaiboon C, Rojanasakul Y, Issaragrisil S. Biochim Biophys Acta Mol Basis Dis. 2018 Nov;1864(11):3739-3753. doi: 10.1016/j.bbadis.2018.09.010. Epub 2018 Sep 11. PubMed |
| Breast cancer survival predicted by TP53 mutation status differs markedly depending on treatment. Ungerleider NA, Rao SG, Shahbandi A, Yee D, Niu T, Frey WD, Jackson JG. Breast Cancer Res. 2018 Oct 1;20(1):115. doi: 10.1186/s13058-018-1044-5. PubMed |
Treatment of a metabolic liver disease by in vivo genome base editing in adult mice.
Villiger L, Grisch-Chan HM, Lindsay H, Ringnalda F, Pogliano CB, Allegri G, Fingerhut R, Haberle J, Matos J, Robinson MD, Thony B, Schwank G.
Nat Med. 2018 Oct;24(10):1519-1525. doi: 10.1038/s41591-018-0209-1. Epub 2018 Oct 8.
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| Genome-wide CRISPR-Cas9 viability screen reveals genes involved in TNF-alpha-induced apoptosis of human umbilical vein endothelial cells. Cai M, Li S, Shuai Y, Li J, Tan J, Zeng Q. J Cell Physiol. 2019 Jun;234(6):9184-9193. doi: 10.1002/jcp.27595. Epub 2018 Oct 14. PubMed |
| FRA1 mediates the activation of keratinocytes: Implications for the development of psoriatic plaques. Zolotarenko A, Chekalin E, Piruzian E, Bruskin S. Biochim Biophys Acta Mol Basis Dis. 2018 Dec;1864(12):3726-3734. doi: 10.1016/j.bbadis.2018.09.016. Epub 2018 Sep 14. PubMed |
| Ubiquitin-specific peptidase 2a (USP2a) deubiquitinates and stabilizes beta-catenin. Kim J, Alavi Naini F, Sun Y, Ma L. Am J Cancer Res. 2018 Sep 1;8(9):1823-1836. eCollection 2018. PubMed |
| Tracing the transitions from pluripotency to germ cell fate with CRISPR screening. Hackett JA, Huang Y, Gunesdogan U, Gretarsson KA, Kobayashi T, Surani MA. Nat Commun. 2018 Oct 16;9(1):4292. doi: 10.1038/s41467-018-06230-0. PubMed |
| Plexin C1 Marks Liver Cancer Cells with Epithelial Phenotype and Is Overexpressed in Hepatocellular Carcinoma. Odabas G, Cetin M, Turhal S, Baloglu H, Sayan AE, Yagci T. Can J Gastroenterol Hepatol. 2018 Sep 19;2018:4040787. doi: 10.1155/2018/4040787. eCollection 2018. PubMed |
The Lineage-Defining Transcription Factors SOX2 and NKX2-1 Determine Lung Cancer Cell Fate and Shape the Tumor Immune Microenvironment.
Mollaoglu G, Jones A, Wait SJ, Mukhopadhyay A, Jeong S, Arya R, Camolotto SA, Mosbruger TL, Stubben CJ, Conley CJ, Bhutkar A, Vahrenkamp JM, Berrett KC, Cessna MH, Lane TE, Witt BL, Salama ME, Gertz J, Jones KB, Snyder EL, Oliver TG.
Immunity. 2018 Oct 16;49(4):764-779.e9. doi: 10.1016/j.immuni.2018.09.020.
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Associated Plasmids |
| INAVA-ARNO complexes bridge mucosal barrier function with inflammatory signaling. Luong P, Hedl M, Yan J, Zuo T, Fu TM, Jiang X, Thiagarajah JR, Hansen SH, Lesser CF, Wu H, Abraham C, Lencer WI. Elife. 2018 Oct 25;7. pii: 38539. doi: 10.7554/eLife.38539. PubMed |
| RbAp48 Protein Is a Critical Component of GPR158/OCN Signaling and Ameliorates Age-Related Memory Loss. Kosmidis S, Polyzos A, Harvey L, Youssef M, Denny CA, Dranovsky A, Kandel ER. Cell Rep. 2018 Oct 23;25(4):959-973.e6. doi: 10.1016/j.celrep.2018.09.077. PubMed |
| Discovery of Natural Compounds Promoting Cardiomyocyte Differentiation. Lee JA, An J, Kang TM, De D, Kim KK. Stem Cells Dev. 2019 Jan 1;28(1):13-27. doi: 10.1089/scd.2018.0153. Epub 2018 Dec 4. PubMed |
| Lentivirus-Mediated RNAi in Skeletal Myogenesis. Kim D, Reyes-Ordonez A, Chen J. Methods Mol Biol. 2019;1889:95-110. doi: 10.1007/978-1-4939-8897-6_7. PubMed |
| Genomic sequencing and editing revealed the GRM8 signaling pathway as potential therapeutic targets of squamous cell lung cancer. Zhang P, Kang B, Xie G, Li S, Gu Y, Shen Y, Zhao X, Ma Y, Li F, Si J, Wang J, Chen J, Yang H, Xu X, Yang Y. Cancer Lett. 2019 Feb 1;442:53-67. doi: 10.1016/j.canlet.2018.10.035. Epub 2018 Oct 27. PubMed |
| Shiga Toxin/Lipopolysaccharide Activates Caspase-4 and Gasdermin D to Trigger Mitochondrial Reactive Oxygen Species Upstream of the NLRP3 Inflammasome. Platnich JM, Chung H, Lau A, Sandall CF, Bondzi-Simpson A, Chen HM, Komada T, Trotman-Grant AC, Brandelli JR, Chun J, Beck PL, Philpott DJ, Girardin SE, Ho M, Johnson RP, MacDonald JA, Armstrong GD, Muruve DA. Cell Rep. 2018 Nov 6;25(6):1525-1536.e7. doi: 10.1016/j.celrep.2018.09.071. PubMed |
| MiRNA-27a sensitizes breast cancer cells to treatment with Selective Estrogen Receptor Modulators. Ljepoja B, Garcia-Roman J, Sommer AK, Wagner E, Roidl A. Breast. 2019 Feb;43:31-38. doi: 10.1016/j.breast.2018.10.007. Epub 2018 Oct 18. PubMed |
| Podoplanin expression is a prognostic biomarker but may be dispensable for the malignancy of glioblastoma. Eisemann T, Costa B, Harter PN, Wick W, Mittelbronn M, Angel P, Peterziel H. Neuro Oncol. 2018 Nov 10. pii: 5168873. doi: 10.1093/neuonc/noy184. PubMed |
| Fibroblast Growth Factor 2 lethally sensitizes cancer cells to stress-targeted therapeutic inhibitors. Dias MH, Fonseca CS, Zeidler JD, Albuquerque LL, da Silva MS, Cararo-Lopes E, Reis MS, Noel V, Dos Santos EO, Prior IA, Armelin HA. Mol Oncol. 2019 Feb;13(2):290-306. doi: 10.1002/1878-0261.12402. Epub 2018 Dec 3. PubMed |
| PPPDE1 promotes hepatocellular carcinoma development by negatively regulate p53 and apoptosis. Xie X, Wang X, Liao W, Fei R, Wu N, Cong X, Chen Q, Wei L, Wang Y, Chen H. Apoptosis. 2019 Feb;24(1-2):135-144. doi: 10.1007/s10495-018-1491-6. PubMed |
| MiR-708-5p is inversely associated with EWS/FLI1 Ewing sarcoma but does not represent a prognostic predictor. Roberto GM, Vieira GM, Delsin LEA, Silva MO, Hakime RG, Engel EE, Scrideli CA, Tone LG, Brassesco MS. Cancer Genet. 2019 Jan;230:21-27. doi: 10.1016/j.cancergen.2018.11.003. Epub 2018 Nov 13. PubMed |
| RORalpha controls inflammatory state of human macrophages. Nejati Moharrami N, Bjorkoy Tande E, Ryan L, Espevik T, Boyartchuk V. PLoS One. 2018 Nov 28;13(11):e0207374. doi: 10.1371/journal.pone.0207374. eCollection 2018. PubMed |
| Interplay between transcription regulators RUNX1 and FUBP1 activates an enhancer of the oncogene c-KIT and amplifies cell proliferation. Debaize L, Jakobczyk H, Avner S, Gaudichon J, Rio AG, Serandour AA, Dorsheimer L, Chalmel F, Carroll JS, Zornig M, Rieger MA, Delalande O, Salbert G, Galibert MD, Gandemer V, Troadec MB. Nucleic Acids Res. 2018 Nov 30;46(21):11214-11228. doi: 10.1093/nar/gky756. PubMed |
| Generation of Stable Expression Mammalian Cell Lines Using Lentivirus. Tandon N, Thakkar KN, LaGory EL, Liu Y, Giaccia AJ. Bio Protoc. 2018 Nov 5;8(21). doi: 10.21769/BioProtoc.3073. PubMed |
| Inhibition of Membrane-Bound BAFF by the Anti-BAFF Antibody Belimumab. Kowalczyk-Quintas C, Chevalley D, Willen L, Jandus C, Vigolo M, Schneider P. Front Immunol. 2018 Nov 20;9:2698. doi: 10.3389/fimmu.2018.02698. eCollection 2018. PubMed |
| ATP13A2 facilitates HDAC6 recruitment to lysosome to promote autophagosome-lysosome fusion. Wang R, Tan J, Chen T, Han H, Tian R, Tan Y, Wu Y, Cui J, Chen F, Li J, Lv L, Guan X, Shang S, Lu J, Zhang Z. J Cell Biol. 2019 Jan 7;218(1):267-284. doi: 10.1083/jcb.201804165. Epub 2018 Dec 11. PubMed |
| Intersectin-1 interacts with the golgin GCC88 to couple the actin network and Golgi architecture. Makhoul C, Gosavi P, Duffield R, Delbridge B, Williamson NA, Gleeson PA. Mol Biol Cell. 2019 Feb 1;30(3):370-386. doi: 10.1091/mbc.E18-05-0313. Epub 2018 Dec 12. PubMed |
| Genome-Wide CRISPR/Cas9 Screening for Identification of Cancer Genes in Cell Lines. Adelmann CH, Wang T, Sabatini DM, Lander ES. Methods Mol Biol. 2019;1907:125-136. doi: 10.1007/978-1-4939-8967-6_10. PubMed |
| Disruption of protein neddylation with MLN4924 attenuates paclitaxel-induced apoptosis and microtubule polymerization in ovarian cancer cells. Hong X, Li S, Li W, Xie M, Wei Z, Guo H, Wei W, Zhang S. Biochem Biophys Res Commun. 2019 Jan 15;508(3):986-990. doi: 10.1016/j.bbrc.2018.12.048. Epub 2018 Dec 11. PubMed |
| Regulation of mitochondrial iron homeostasis by sideroflexin 2. Mon EE, Wei FY, Ahmad RNR, Yamamoto T, Moroishi T, Tomizawa K. J Physiol Sci. 2019 Mar;69(2):359-373. doi: 10.1007/s12576-018-0652-2. Epub 2018 Dec 20. PubMed |
Optimized libraries for CRISPR-Cas9 genetic screens with multiple modalities.
Sanson KR, Hanna RE, Hegde M, Donovan KF, Strand C, Sullender ME, Vaimberg EW, Goodale A, Root DE, Piccioni F, Doench JG.
Nat Commun. 2018 Dec 21;9(1):5416. doi: 10.1038/s41467-018-07901-8.
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| Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis. Tiemann K, Garri C, Lee SB, Malihi PD, Park M, Alvarez RM, Yap LP, Mallick P, Katz JE, Gross ME, Kani K. Oncogene. 2019 Apr;38(16):3003-3018. doi: 10.1038/s41388-018-0638-9. Epub 2018 Dec 21. PubMed |
| Allosteric Inhibition of Ubiquitin-like Modifications by a Class of Inhibitor of SUMO-Activating Enzyme. Li YJ, Du L, Wang J, Vega R, Lee TD, Miao Y, Aldana-Masangkay G, Samuels ER, Li B, Ouyang SX, Colayco SA, Bobkova EV, Divlianska DB, Sergienko E, Chung TDY, Fakih M, Chen Y. Cell Chem Biol. 2019 Feb 21;26(2):278-288.e6. doi: 10.1016/j.chembiol.2018.10.026. Epub 2018 Dec 20. PubMed |
| Sensitive ADAR editing reporter in cancer cells enables high-throughput screening of small molecule libraries. Fritzell K, Xu LD, Otrocka M, Andreasson C, Ohman M. Nucleic Acids Res. 2019 Feb 28;47(4):e22. doi: 10.1093/nar/gky1228. PubMed |
| IL-8 Secreted from M2 Macrophages Promoted Prostate Tumorigenesis via STAT3/MALAT1 Pathway. Zheng T, Ma G, Tang M, Li Z, Xu R. Int J Mol Sci. 2018 Dec 27;20(1). pii: ijms20010098. doi: 10.3390/ijms20010098. PubMed |
| Novel mutations in mevalonate kinase cause disseminated superficial actinic porokeratosis. Zhu T, Tian D, Zhang L, Xu X, Xia K, Hu Z, Xiong Z, Tan J. Br J Dermatol. 2018 Dec 30. doi: 10.1111/bjd.17596. PubMed |
| Structural insights into trans-histone regulation of H3K4 methylation by unique histone H4 binding of MLL3/4. Liu Y, Qin S, Chen TY, Lei M, Dhar SS, Ho JC, Dong A, Loppnau P, Li Y, Lee MG, Min J. Nat Commun. 2019 Jan 3;10(1):36. doi: 10.1038/s41467-018-07906-3. PubMed |
Growth Factor-Independent 1 Is a Tumor Suppressor Gene in Colorectal Cancer.
Chen MS, Lo YH, Chen X, Williams CS, Donnelly JM, Criss ZK 2nd, Patel S, Butkus JM, Dubrulle J, Finegold MJ, Shroyer NF.
Mol Cancer Res. 2019 Mar;17(3):697-708. doi: 10.1158/1541-7786.MCR-18-0666. Epub 2019 Jan 3.
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| UBQLN4 Represses Homologous Recombination and Is Overexpressed in Aggressive Tumors. Jachimowicz RD, Beleggia F, Isensee J, Velpula BB, Goergens J, Bustos MA, Doll MA, Shenoy A, Checa-Rodriguez C, Wiederstein JL, Baranes-Bachar K, Bartenhagen C, Hertwig F, Teper N, Nishi T, Schmitt A, Distelmaier F, Ludecke HJ, Albrecht B, Kruger M, Schumacher B, Geiger T, Hoon DSB, Huertas P, Fischer M, Hucho T, Peifer M, Ziv Y, Reinhardt HC, Wieczorek D, Shiloh Y. Cell. 2019 Jan 24;176(3):505-519.e22. doi: 10.1016/j.cell.2018.11.024. Epub 2019 Jan 3. PubMed |
| METTL13 Methylation of eEF1A Increases Translational Output to Promote Tumorigenesis. Liu S, Hausmann S, Carlson SM, Fuentes ME, Francis JW, Pillai R, Lofgren SM, Hulea L, Tandoc K, Lu J, Li A, Nguyen ND, Caporicci M, Kim MP, Maitra A, Wang H, Wistuba II, Porco JA Jr, Bassik MC, Elias JE, Song J, Topisirovic I, Van Rechem C, Mazur PK, Gozani O. Cell. 2019 Jan 24;176(3):491-504.e21. doi: 10.1016/j.cell.2018.11.038. Epub 2019 Jan 3. PubMed |
| Functional Genomics Reveals Synthetic Lethality between Phosphogluconate Dehydrogenase and Oxidative Phosphorylation. Sun Y, Bandi M, Lofton T, Smith M, Bristow CA, Carugo A, Rogers N, Leonard P, Chang Q, Mullinax R, Han J, Shi X, Seth S, Meyers BA, Miller M, Miao L, Ma X, Feng N, Giuliani V, Geck Do M, Czako B, Palmer WS, Mseeh F, Asara JM, Jiang Y, Morlacchi P, Zhao S, Peoples M, Tieu TN, Warmoes MO, Lorenzi PL, Muller FL, DePinho RA, Draetta GF, Toniatti C, Jones P, Heffernan TP, Marszalek JR. Cell Rep. 2019 Jan 8;26(2):469-482.e5. doi: 10.1016/j.celrep.2018.12.043. PubMed |
| Chromodomain Helicase DNA-Binding Protein 7 Is Suppressed in the Perinecrotic/Ischemic Microenvironment and Is a Novel Regulator of Glioblastoma Angiogenesis. Boyd NH, Walker K, Ayokanmbi A, Gordon ER, Whetsel J, Smith CM, Sanchez RG, Lubin FD, Chakraborty A, Tran AN, Herting C, Hambardzumyan D, Yancey Gillespie G, Hackney JR, Cooper SJ, Jiao K, Hjelmeland AB. Stem Cells. 2019 Apr;37(4):453-462. doi: 10.1002/stem.2969. Epub 2019 Jan 24. PubMed |
| The RNA-Binding Protein PUM2 Impairs Mitochondrial Dynamics and Mitophagy During Aging. D'Amico D, Mottis A, Potenza F, Sorrentino V, Li H, Romani M, Lemos V, Schoonjans K, Zamboni N, Knott G, Schneider BL, Auwerx J. Mol Cell. 2019 Feb 21;73(4):775-787.e10. doi: 10.1016/j.molcel.2018.11.034. Epub 2019 Jan 11. PubMed |
| Exploitation of nuclear protein SFPQ by the encephalomyocarditis virus to facilitate its replication. Zhou B, Wu F, Han J, Qi F, Ni T, Qian F. Biochem Biophys Res Commun. 2019 Feb 26;510(1):65-71. doi: 10.1016/j.bbrc.2019.01.032. Epub 2019 Jan 18. PubMed |
| Mitochondrial fusion supports increased oxidative phosphorylation during cell proliferation. Yao CH, Wang R, Wang Y, Kung CP, Weber JD, Patti GJ. Elife. 2019 Jan 29;8. pii: 41351. doi: 10.7554/eLife.41351. PubMed |
| Pharmacological Targeting of STK19 Inhibits Oncogenic NRAS-Driven Melanomagenesis. Yin C, Zhu B, Zhang T, Liu T, Chen S, Liu Y, Li X, Miao X, Li S, Mi X, Zhang J, Li L, Wei G, Xu ZX, Gao X, Huang C, Wei Z, Goding CR, Wang P, Deng X, Cui R. Cell. 2019 Feb 21;176(5):1113-1127.e16. doi: 10.1016/j.cell.2019.01.002. Epub 2019 Jan 31. PubMed |
| Identification of Novel Regulatory Genes in APAP Induced Hepatocyte Toxicity by a Genome-Wide CRISPR-Cas9 Screen. Shortt K, Heruth DP, Zhang N, Wu W, Singh S, Li DY, Zhang LQ, Wyckoff GJ, Qi LS, Friesen CA, Ye SQ. Sci Rep. 2019 Feb 4;9(1):1396. doi: 10.1038/s41598-018-37940-6. PubMed |
| Protein kinase Calpha-mediated phosphorylation of Twist1 at Ser-144 prevents Twist1 ubiquitination and stabilizes it. Tedja R, Roberts CM, Alvero AB, Cardenas C, Yang-Hartwich Y, Spadinger S, Pitruzzello M, Yin G, Glackin CA, Mor G. J Biol Chem. 2019 Mar 29;294(13):5082-5093. doi: 10.1074/jbc.RA118.005921. Epub 2019 Feb 7. PubMed |
| Development of a non-radioactive screening assay to detect chemicals disrupting the human sodium iodide symporter activity. Dong H, Atlas E, Wade MG. Toxicol In Vitro. 2019 Jun;57:39-47. doi: 10.1016/j.tiv.2019.01.021. Epub 2019 Feb 7. PubMed |
| Andrographolide Enhances TRAIL-Induced Apoptosis via p53-Mediated Death Receptors Up-Regulation and Suppression of the NF-small ka, CyrillicB Pathway in Bladder Cancer Cells. Deng Y, Bi R, Guo H, Yang J, Du Y, Wang C, Wei W. Int J Biol Sci. 2019 Jan 24;15(3):688-700. doi: 10.7150/ijbs.30847. eCollection 2019. PubMed |
| Canthin-6-One Accelerates Alpha-Synuclein Degradation by Enhancing UPS Activity: Drug Target Identification by CRISPR-Cas9 Whole Genome-Wide Screening Technology. Yuan NN, Cai CZ, Wu MY, Zhu Q, Su H, Li M, Ren J, Tan JQ, Lu JH. Front Pharmacol. 2019 Jan 28;10:16. doi: 10.3389/fphar.2019.00016. eCollection 2019. PubMed |
| ORAI1 and ORAI3 in Breast Cancer Molecular Subtypes and the Identification of ORAI3 as a Hypoxia Sensitive Gene and a Regulator of Hypoxia Responses. Azimi I, Milevskiy MJG, Chalmers SB, Yapa KTDS, Robitaille M, Henry C, Baillie GJ, Thompson EW, Roberts-Thomson SJ, Monteith GR. Cancers (Basel). 2019 Feb 11;11(2). pii: cancers11020208. doi: 10.3390/cancers11020208. PubMed |
| ETS1 is coexpressed with ZEB2 and mediates ZEB2-induced epithelial-mesenchymal transition in human tumors. Yalim-Camci I, Balcik-Ercin P, Cetin M, Odabas G, Tokay N, Sayan AE, Yagci T. Mol Carcinog. 2019 Jun;58(6):1068-1081. doi: 10.1002/mc.22994. Epub 2019 Mar 6. PubMed |
| MST1 Suppresses Pancreatic Cancer Progression via ROS-Induced Pyroptosis. Cui J, Zhou Z, Yang H, Jiao F, Li N, Gao Y, Wang L, Chen J, Quan M. Mol Cancer Res. 2019 Jun;17(6):1316-1325. doi: 10.1158/1541-7786.MCR-18-0910. Epub 2019 Feb 22. PubMed |
| A positive role of c-Myc in regulating androgen receptor and its splice variants in prostate cancer. Bai S, Cao S, Jin L, Kobelski M, Schouest B, Wang X, Ungerleider N, Baddoo M, Zhang W, Corey E, Vessella RL, Dong X, Zhang K, Yu X, Flemington EK, Dong Y. Oncogene. 2019 Jun;38(25):4977-4989. doi: 10.1038/s41388-019-0768-8. Epub 2019 Feb 28. PubMed |
Phosphoinositide Interactions Position cGAS at the Plasma Membrane to Ensure Efficient Distinction between Self- and Viral DNA.
Barnett KC, Coronas-Serna JM, Zhou W, Ernandes MJ, Cao A, Kranzusch PJ, Kagan JC.
Cell. 2019 Mar 7;176(6):1432-1446.e11. doi: 10.1016/j.cell.2019.01.049. Epub 2019 Feb 28.
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| Base editing the mammalian genome. Schatoff EM, Zafra MP, Dow LE. Methods. 2019 Jul 15;164-165:100-108. doi: 10.1016/j.ymeth.2019.02.022. Epub 2019 Mar 2. PubMed |
| FMR1 Reactivating Treatments in Fragile X iPSC-Derived Neural Progenitors In Vitro and In Vivo. Vershkov D, Fainstein N, Suissa S, Golan-Lev T, Ben-Hur T, Benvenisty N. Cell Rep. 2019 Mar 5;26(10):2531-2539.e4. doi: 10.1016/j.celrep.2019.02.026. PubMed |
| MicroRNA-Mediated Suppression of the TGF-beta Pathway Confers Transmissible and Reversible CDK4/6 Inhibitor Resistance. Cornell L, Wander SA, Visal T, Wagle N, Shapiro GI. Cell Rep. 2019 Mar 5;26(10):2667-2680.e7. doi: 10.1016/j.celrep.2019.02.023. PubMed |
| Genome-wide screening identifies novel genes and biological processes implicated in cisplatin resistance. Ko T, Li S. FASEB J. 2019 Jun;33(6):7143-7154. doi: 10.1096/fj.201801534RR. Epub 2019 Mar 7. PubMed |
Innate Immune Signaling Organelles Display Natural and Programmable Signaling Flexibility.
Tan Y, Kagan JC.
Cell. 2019 Apr 4;177(2):384-398.e11. doi: 10.1016/j.cell.2019.01.039. Epub 2019 Mar 7.
PubMed
Associated Plasmids |
A Neuron-Optimized CRISPR/dCas9 Activation System for Robust and Specific Gene Regulation.
Savell KE, Bach SV, Zipperly ME, Revanna JS, Goska NA, Tuscher JJ, Duke CG, Sultan FA, Burke JN, Williams D, Ianov L, Day JJ.
eNeuro. 2019 Mar 7;6(1). pii: eN-MNT-0495-18. doi: 10.1523/ENEURO.0495-18.2019. eCollection 2019 Jan-Feb.
PubMed
Associated Plasmids |
| Single-Cell Heterogeneity Analysis and CRISPR Screen Identify Key beta-Cell-Specific Disease Genes. Fang Z, Weng C, Li H, Tao R, Mai W, Liu X, Lu L, Lai S, Duan Q, Alvarez C, Arvan P, Wynshaw-Boris A, Li Y, Pei Y, Jin F, Li Y. Cell Rep. 2019 Mar 12;26(11):3132-3144.e7. doi: 10.1016/j.celrep.2019.02.043. PubMed |
| Ribosomal protein RPL22/eL22 regulates the cell cycle by acting as an inhibitor of the CDK4-cyclin D complex. Del Toro N, Fernandez-Ruiz A, Mignacca L, Kalegari P, Rowell MC, Igelmann S, Saint-Germain E, Benfdil M, Lopes-Paciencia S, Brakier-Gingras L, Bourdeau V, Ferbeyre G, Lessard F. Cell Cycle. 2019 Mar - Apr;18(6-7):759-770. doi: 10.1080/15384101.2019.1593708. Epub 2019 Mar 28. PubMed |
| Assessment of different strategies for scalable production and proliferation of human myoblasts. Chua MJ, Yildirim ED, Tan JE, Chua YB, Low SC, Ding SLS, Li CW, Jiang Z, Teh BT, Yu K, Shyh-Chang N. Cell Prolif. 2019 May;52(3):e12602. doi: 10.1111/cpr.12602. Epub 2019 Mar 19. PubMed |
| Negative Regulation of p53-Induced Senescence by N-WASP Is Crucial for DMBA/TPA-Induced Skin Tumor Formation. Li H, Petersen S, Garcia Mariscal A, Brakebusch C. Cancer Res. 2019 May 1;79(9):2167-2181. doi: 10.1158/0008-5472.CAN-18-1253. Epub 2019 Mar 20. PubMed |
A reference collection of patient-derived cell line and xenograft models of proneural, classical and mesenchymal glioblastoma.
Stringer BW, Day BW, D'Souza RCJ, Jamieson PR, Ensbey KS, Bruce ZC, Lim YC, Goasdoue K, Offenhauser C, Akgul S, Allan S, Robertson T, Lucas P, Tollesson G, Campbell S, Winter C, Do H, Dobrovic A, Inglis PL, Jeffree RL, Johns TG, Boyd AW.
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PubMed
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| A Systematic Pan-Cancer Analysis of Genetic Heterogeneity Reveals Associations with Epigenetic Modifiers. de Matos MR, Posa I, Carvalho FS, Morais VA, Grosso AR, de Almeida SF. Cancers (Basel). 2019 Mar 20;11(3). pii: cancers11030391. doi: 10.3390/cancers11030391. PubMed |
| Mutant p53 regulates LPA signaling through lysophosphatidic acid phosphatase type 6. Chryplewicz A, Tienda SM, Nahotko DA, Peters PN, Lengyel E, Eckert MA. Sci Rep. 2019 Mar 26;9(1):5195. doi: 10.1038/s41598-019-41352-5. PubMed |
| Myristoylated alanine-rich C-kinase substrate effector domain phosphorylation regulates the growth and radiation sensitization of glioblastoma. Eustace NJ, Anderson JC, Langford CP, Trummell HQ, Hicks PH, Jarboe JS, Mobley JA, Hjelmeland AB, Hackney JR, Pedersen RT, Cosby K, Gillespie GY, Bonner JA, Willey CD. Int J Oncol. 2019 Jun;54(6):2039-2053. doi: 10.3892/ijo.2019.4766. Epub 2019 Mar 29. PubMed |
| ATG2 transports lipids to promote autophagosome biogenesis. Valverde DP, Yu S, Boggavarapu V, Kumar N, Lees JA, Walz T, Reinisch KM, Melia TJ. J Cell Biol. 2019 Jun 3;218(6):1787-1798. doi: 10.1083/jcb.201811139. Epub 2019 Apr 5. PubMed |
| Bok regulates mitochondrial fusion and morphology. Schulman JJ, Szczesniak LM, Bunker EN, Nelson HA, Roe MW, Wagner LE 2nd, Yule DI, Wojcikiewicz RJH. Cell Death Differ. 2019 Dec;26(12):2682-2694. doi: 10.1038/s41418-019-0327-4. Epub 2019 Apr 11. PubMed |
| Oleic acid-induced defective autolysosome shows impaired lipid degradation. Lee DH, Ahn J, Jang YJ, Ha TY, Jung CH. Biochem Biophys Res Commun. 2019 Jun 4;513(3):553-559. doi: 10.1016/j.bbrc.2019.04.040. Epub 2019 Apr 10. PubMed |
| LLGL2 rescues nutrient stress by promoting leucine uptake in ER(+) breast cancer. Saito Y, Li L, Coyaud E, Luna A, Sander C, Raught B, Asara JM, Brown M, Muthuswamy SK. Nature. 2019 May;569(7755):275-279. doi: 10.1038/s41586-019-1126-2. Epub 2019 Apr 17. PubMed |
| Visualizing Engrafted Human Cancer and Therapy Responses in Immunodeficient Zebrafish. Yan C, Brunson DC, Tang Q, Do D, Iftimia NA, Moore JC, Hayes MN, Welker AM, Garcia EG, Dubash TD, Hong X, Drapkin BJ, Myers DT, Phat S, Volorio A, Marvin DL, Ligorio M, Dershowitz L, McCarthy KM, Karabacak MN, Fletcher JA, Sgroi DC, Iafrate JA, Maheswaran S, Dyson NJ, Haber DA, Rawls JF, Langenau DM. Cell. 2019 Jun 13;177(7):1903-1914.e14. doi: 10.1016/j.cell.2019.04.004. Epub 2019 Apr 25. PubMed |
| The transcription factor CBFB suppresses breast cancer through orchestrating translation and transcription. Malik N, Yan H, Moshkovich N, Palangat M, Yang H, Sanchez V, Cai Z, Peat TJ, Jiang S, Liu C, Lee M, Mock BA, Yuspa SH, Larson D, Wakefield LM, Huang J. Nat Commun. 2019 May 6;10(1):2071. doi: 10.1038/s41467-019-10102-6. PubMed |
| BCL2 Amplicon Loss and Transcriptional Remodeling Drives ABT-199 Resistance in B Cell Lymphoma Models. Zhao X, Ren Y, Lawlor M, Shah BD, Park PMC, Lwin T, Wang X, Liu K, Wang M, Gao J, Li T, Xu M, Silva AS, Lee K, Zhang T, Koomen JM, Jiang H, Sudalagunta PR, Meads MB, Cheng F, Bi C, Fu K, Fan H, Dalton WS, Moscinski LC, Shain KH, Sotomayor EM, Wang GG, Gray NS, Cleveland JL, Qi J, Tao J. Cancer Cell. 2019 May 13;35(5):752-766.e9. doi: 10.1016/j.ccell.2019.04.005. PubMed |
| Genetic and Functional Dissection of the Role of Individual 5-HT2 Receptors as Entry Receptors for JC Polyomavirus. Assetta B, Morris-Love J, Gee GV, Atkinson AL, O'Hara BA, Maginnis MS, Haley SA, Atwood WJ. Cell Rep. 2019 May 14;27(7):1960-1966.e6. doi: 10.1016/j.celrep.2019.04.067. PubMed |
| Cysteine dioxygenase 1 is a metabolic liability for non-small cell lung cancer. Kang YP, Torrente L, Falzone A, Elkins CM, Liu M, Asara JM, Dibble CC, DeNicola GM. Elife. 2019 May 20;8. pii: 45572. doi: 10.7554/eLife.45572. PubMed |
| Artemisinin compounds sensitize cancer cells to ferroptosis by regulating iron homeostasis. Chen GQ, Benthani FA, Wu J, Liang D, Bian ZX, Jiang X. Cell Death Differ. 2019 May 21. pii: 10.1038/s41418-019-0352-3. doi: 10.1038/s41418-019-0352-3. PubMed |
| TRAIL-R1 and TRAIL-R2 Mediate TRAIL-Dependent Apoptosis in Activated Primary Human B Lymphocytes. Staniek J, Lorenzetti R, Heller B, Janowska I, Schneider P, Unger S, Warnatz K, Seidl M, Venhoff N, Thiel J, Smulski CR, Rizzi M. Front Immunol. 2019 Apr 30;10:951. doi: 10.3389/fimmu.2019.00951. eCollection 2019. PubMed |
| Genetic Modification of Human Primary Keratinocytes by Lentiviral Vectors. Freije A, Sanz-Gomez N, Gandarillas A. Methods Mol Biol. 2019 May 24. doi: 10.1007/7651_2019_238. PubMed |
| Preferential expression of sialyl 6'-sulfo N-acetyllactosamine-capped O-glycans on high endothelial venules in human peripheral lymph nodes. Tsutsumiuchi M, Hoshino H, Kogami A, Tsutsumiuchi T, Yokoyama O, Akama TO, Kobayashi M. Lab Invest. 2019 May 31. pii: 10.1038/s41374-019-0267-0. doi: 10.1038/s41374-019-0267-0. PubMed |
| Human evolved regulatory elements modulate genes involved in cortical expansion and neurodevelopmental disease susceptibility. Won H, Huang J, Opland CK, Hartl CL, Geschwind DH. Nat Commun. 2019 Jun 3;10(1):2396. doi: 10.1038/s41467-019-10248-3. PubMed |
| IFI16 Targets the Transcription Factor Sp1 to Suppress HIV-1 Transcription and Latency Reactivation. Hotter D, Bosso M, Jonsson KL, Krapp C, Sturzel CM, Das A, Littwitz-Salomon E, Berkhout B, Russ A, Wittmann S, Gramberg T, Zheng Y, Martins LJ, Planelles V, Jakobsen MR, Hahn BH, Dittmer U, Sauter D, Kirchhoff F. Cell Host Microbe. 2019 Jun 12;25(6):858-872.e13. doi: 10.1016/j.chom.2019.05.002. Epub 2019 Jun 4. PubMed |
| Berberine promotes the recruitment and activation of brown adipose tissue in mice and humans. Wu L, Xia M, Duan Y, Zhang L, Jiang H, Hu X, Yan H, Zhang Y, Gu Y, Shi H, Li J, Gao X, Li J. Cell Death Dis. 2019 Jun 13;10(6):468. doi: 10.1038/s41419-019-1706-y. PubMed |
| Somatic loss of PIK3R1 may sensitize breast cancer to inhibitors of the MAPK pathway. Turturro SB, Najor MS, Yung T, Portt L, Malarkey CS, Abukhdeir AM, Cobleigh MA. Breast Cancer Res Treat. 2019 Sep;177(2):325-333. doi: 10.1007/s10549-019-05320-x. Epub 2019 Jun 17. PubMed |
| A large-scale CRISPR screen and identification of essential genes in cellular senescence bypass. Liu X, Wei L, Dong Q, Liu L, Zhang MQ, Xie Z, Wang X. Aging (Albany NY). 2019 Jun 20;11(12):4011-4031. doi: 10.18632/aging.102034. PubMed |
| Retinol binding protein 4 mediates MEHP-induced glucometabolic abnormalities in HepG2 cells. Wang F, Chang C, Li R, Zhang Z, Jiang H, Zeng N, Li D, Chen L, Xiao Y, Chen W, Wang Q. Toxicology. 2019 Aug 1;424:152236. doi: 10.1016/j.tox.2019.06.007. Epub 2019 Jun 20. PubMed |
| Cytokine Storm Combined with Humoral Immune Response Defect in Fatal Hemorrhagic Fever with Renal Syndrome Case, Tatarstan, Russia. Garanina E, Martynova E, Davidyuk Y, Kabwe E, Ivanov K, Titova A, Markelova M, Zhuravleva M, Cherepnev G, Shakirova VG, Khaertynova I, Tarlinton R, Rizvanov A, Khaiboullina S, Morzunov S. Viruses. 2019 Jul 2;11(7). pii: v11070601. doi: 10.3390/v11070601. PubMed |
| Genetic interactions of G-quadruplexes in humans. Zyner KG, Mulhearn DS, Adhikari S, Martinez Cuesta S, Di Antonio M, Erard N, Hannon GJ, Tannahill D, Balasubramanian S. Elife. 2019 Jul 9;8:e46793. doi: 10.7554/eLife.46793. PubMed |
| Adenovirus oncoprotein E4orf6 triggers Cullin5 neddylation to activate the CLR5 E3 ligase for p53 degradation. Guo H, Shen S, Li Y, Bi R, Zhang N, Zheng W, Deng Y, Yang Y, Yu XF, Wang C, Wei W. Biochem Biophys Res Commun. 2019 Sep 3;516(4):1242-1247. doi: 10.1016/j.bbrc.2019.07.028. Epub 2019 Jul 10. PubMed |
| Endoplasmic reticulum stress and proteasome pathway involvement in human podocyte injury with a truncated COL4A3 mutation. Zhang HD, Huang JN, Liu YZ, Ren H, Xie JY, Chen N. Chin Med J (Engl). 2019 Aug 5;132(15):1823-1832. doi: 10.1097/CM9.0000000000000294. PubMed |
| The RNA-binding protein QKI controls alternative splicing in vascular cells, producing an effective model for therapy. Caines R, Cochrane A, Kelaini S, Vila-Gonzalez M, Yang C, Eleftheriadou M, Moez A, Stitt AW, Zeng L, Grieve DJ, Margariti A. J Cell Sci. 2019 Aug 15;132(16). pii: jcs.230276. doi: 10.1242/jcs.230276. PubMed |
| P11 Loss-of-Function is Associated with Decreased Cell Proliferation and Neurobehavioral Disorders in Mice. Liu G, Wang Y, Zheng W, Cheng H, Zhou R. Int J Biol Sci. 2019 May 20;15(7):1383-1395. doi: 10.7150/ijbs.33773. eCollection 2019. PubMed |
| Activation of PARP-1 by snoRNAs Controls Ribosome Biogenesis and Cell Growth via the RNA Helicase DDX21. Kim DS, Camacho CV, Nagari A, Malladi VS, Challa S, Kraus WL. Mol Cell. 2019 Sep 19;75(6):1270-1285.e14. doi: 10.1016/j.molcel.2019.06.020. Epub 2019 Jul 24. PubMed |
| A Cancer-Associated Missense Mutation in PP2A-Aalpha Increases Centrosome Clustering during Mitosis. Antao NV, Marcet-Ortega M, Cifani P, Kentsis A, Foley EA. iScience. 2019 Sep 27;19:74-82. doi: 10.1016/j.isci.2019.07.018. Epub 2019 Jul 17. PubMed |
| CRISPR/Cas9 Screens Reveal Multiple Layers of B cell CD40 Regulation. Jiang C, Trudeau SJ, Cheong TC, Guo R, Teng M, Wang LW, Wang Z, Pighi C, Gautier-Courteille C, Ma Y, Jiang S, Wang C, Zhao B, Paillard L, Doench JG, Chiarle R, Gewurz BE. Cell Rep. 2019 Jul 30;28(5):1307-1322.e8. doi: 10.1016/j.celrep.2019.06.079. PubMed |
| Id4 Downstream of Notch2 Maintains Neural Stem Cell Quiescence in the Adult Hippocampus. Zhang R, Boareto M, Engler A, Louvi A, Giachino C, Iber D, Taylor V. Cell Rep. 2019 Aug 6;28(6):1485-1498.e6. doi: 10.1016/j.celrep.2019.07.014. PubMed |
| Oct4 and Hnf4alpha-induced hepatic stem cells ameliorate chronic liver injury in liver fibrosis model. Park MR, Wong MS, Arauzo-Bravo MJ, Lee H, Nam D, Park SY, Seo HD, Lee SM, Zeilhofer HF, Zaehres H, Scholer HR, Kim JB. PLoS One. 2019 Aug 12;14(8):e0221085. doi: 10.1371/journal.pone.0221085. eCollection 2019. PubMed |
| Imaging Single mRNA Molecules in Mammalian Cells Using an Optimized MS2-MCP System. Vera M, Tutucci E, Singer RH. Methods Mol Biol. 2019;2038:3-20. doi: 10.1007/978-1-4939-9674-2_1. PubMed |
| Visualization of Single mRNAs in Live Neurons. Shim JY, Lee BH, Park HY. Methods Mol Biol. 2019;2038:47-61. doi: 10.1007/978-1-4939-9674-2_4. PubMed |
| The long noncoding RNA CHROME regulates cholesterol homeostasis in primate. Hennessy EJ, van Solingen C, Scacalossi KR, Ouimet M, Afonso MS, Prins J, Koelwyn GJ, Sharma M, Ramkhelawon B, Carpenter S, Busch A, Chernogubova E, Matic LP, Hedin U, Maegdefessel L, Caffrey BE, Hussein MA, Ricci EP, Temel RE, Garabedian MJ, Berger JS, Vickers KC, Kanke M, Sethupathy P, Teupser D, Holdt LM, Moore KJ. Nat Metab. 2019 Jan;1(1):98-110. doi: 10.1038/s42255-018-0004-9. Epub 2018 Dec 3. PubMed |
| Increased expression of heme-binding protein 1 early in Alzheimer's disease is linked to neurotoxicity. Yagensky O, Kohansal-Nodehi M, Gunaseelan S, Rabe T, Zafar S, Zerr I, Hartig W, Urlaub H, Chua JJ. Elife. 2019 Aug 27;8. pii: 47498. doi: 10.7554/eLife.47498. PubMed |
| Modeling of Cisplatin-Induced Signaling Dynamics in Triple-Negative Breast Cancer Cells Reveals Mediators of Sensitivity. Heijink AM, Everts M, Honeywell ME, Richards R, Kok YP, de Vries EGE, Lee MJ, van Vugt MATM. Cell Rep. 2019 Aug 27;28(9):2345-2357.e5. doi: 10.1016/j.celrep.2019.07.070. PubMed |
| Differential Activation of the Transcription Factor IRF1 Underlies the Distinct Immune Responses Elicited by Type I and Type III Interferons. Forero A, Ozarkar S, Li H, Lee CH, Hemann EA, Nadjsombati MS, Hendricks MR, So L, Green R, Roy CN, Sarkar SN, von Moltke J, Anderson SK, Gale M Jr, Savan R. Immunity. 2019 Sep 17;51(3):451-464.e6. doi: 10.1016/j.immuni.2019.07.007. Epub 2019 Aug 27. PubMed |
| New factors for protein transport identified by a genome-wide CRISPRi screen in mammalian cells. Bassaganyas L, Popa SJ, Horlbeck M, Puri C, Stewart SE, Campelo F, Ashok A, Butnaru CM, Brouwers N, Heydari K, Ripoche J, Weissman J, Rubinsztein DC, Schekman R, Malhotra V, Moreau K, Villeneuve J. J Cell Biol. 2019 Nov 4;218(11):3861-3879. doi: 10.1083/jcb.201902028. Epub 2019 Sep 5. PubMed |
| RhTyrRS (Y341A), a novel human tyrosyl-tRNA synthetase mutant, stimulates thrombopoiesis through activation of the VEGF-R II/NF-kappaB pathway. Shi Y, Yu J, Zhang Y, Zhao B, Li Y, Ye Y, Yu Q, Yu M, Mo W, Gu J. Biochem Pharmacol. 2019 Nov;169:113634. doi: 10.1016/j.bcp.2019.113634. Epub 2019 Sep 9. PubMed |
| Iron chelation and 2-oxoglutarate-dependent dioxygenase inhibition suppress mantle cell lymphoma's cyclin D1. Babosova O, Kapralova K, Raskova Kafkova L, Korinek V, Divoky V, Prchal JT, Lanikova L. J Cell Mol Med. 2019 Nov;23(11):7785-7795. doi: 10.1111/jcmm.14655. Epub 2019 Sep 13. PubMed |
| Unique and Shared Epigenetic Programs of the CREBBP and EP300 Acetyltransferases in Germinal Center B Cells Reveal Targetable Dependencies in Lymphoma. Meyer SN, Scuoppo C, Vlasevska S, Bal E, Holmes AB, Holloman M, Garcia-Ibanez L, Nataraj S, Duval R, Vantrimpont T, Basso K, Brooks N, Dalla-Favera R, Pasqualucci L. Immunity. 2019 Sep 17;51(3):535-547.e9. doi: 10.1016/j.immuni.2019.08.006. Epub 2019 Sep 10. PubMed |
| Genome-wide screening identifies novel genes implicated in cellular sensitivity to BRAF(V600E) expression. Ko T, Sharma R, Li S. Oncogene. 2020 Jan;39(4):723-738. doi: 10.1038/s41388-019-1022-0. Epub 2019 Sep 23. PubMed |
| Dynamic Incorporation of Histone H3 Variants into Chromatin Is Essential for Acquisition of Aggressive Traits and Metastatic Colonization. Gomes AP, Ilter D, Low V, Rosenzweig A, Shen ZJ, Schild T, Rivas MA, Er EE, McNally DR, Mutvei AP, Han J, Ou YH, Cavaliere P, Mullarky E, Nagiec M, Shin S, Yoon SO, Dephoure N, Massague J, Melnick AM, Cantley LC, Tyler JK, Blenis J. Cancer Cell. 2019 Oct 14;36(4):402-417.e13. doi: 10.1016/j.ccell.2019.08.006. Epub 2019 Sep 26. PubMed |
An AND-Gated Drug and Photoactivatable Cre-loxP System for Spatiotemporal Control in Cell-Based Therapeutics.
Allen ME, Zhou W, Thangaraj J, Kyriakakis P, Wu Y, Huang Z, Ho P, Pan Y, Limsakul P, Xu X, Wang Y.
ACS Synth Biol. 2019 Oct 18;8(10):2359-2371. doi: 10.1021/acssynbio.9b00175. Epub 2019 Oct 8.
PubMed
Associated Plasmids |
| The MTH1 inhibitor TH588 is a microtubule-modulating agent that eliminates cancer cells by activating the mitotic surveillance pathway. Gul N, Karlsson J, Tangemo C, Linsefors S, Tuyizere S, Perkins R, Ala C, Zou Z, Larsson E, Bergo MO, Lindahl P. Sci Rep. 2019 Oct 11;9(1):14667. doi: 10.1038/s41598-019-51205-w. PubMed |
| A rapid assay of human thyroid peroxidase activity. Dong H, Godlewska M, Wade MG. Toxicol In Vitro. 2020 Feb;62:104662. doi: 10.1016/j.tiv.2019.104662. Epub 2019 Oct 16. PubMed |
| Re-programing Chromatin with a Bifunctional LSD1/HDAC Inhibitor Induces Therapeutic Differentiation in DIPG. Anastas JN, Zee BM, Kalin JH, Kim M, Guo R, Alexandrescu S, Blanco MA, Giera S, Gillespie SM, Das J, Wu M, Nocco S, Bonal DM, Nguyen QD, Suva ML, Bernstein BE, Alani R, Golub TR, Cole PA, Filbin MG, Shi Y. Cancer Cell. 2019 Nov 11;36(5):528-544.e10. doi: 10.1016/j.ccell.2019.09.005. Epub 2019 Oct 17. PubMed |
| Vaccinia Virus Ankyrin-Repeat/F-Box Protein Targets Interferon-Induced IFITs for Proteasomal Degradation. Liu R, Olano LR, Mirzakhanyan Y, Gershon PD, Moss B. Cell Rep. 2019 Oct 22;29(4):816-828.e6. doi: 10.1016/j.celrep.2019.09.039. PubMed |
| RAG-Mediated DNA Breaks Attenuate PU.1 Activity in Early B Cells through Activation of a SPIC-BCLAF1 Complex. Soodgupta D, White LS, Yang W, Johnston R, Andrews JM, Kohyama M, Murphy KM, Mosammaparast N, Payton JE, Bednarski JJ. Cell Rep. 2019 Oct 22;29(4):829-843.e5. doi: 10.1016/j.celrep.2019.09.026. PubMed |
| Genes essential for embryonic stem cells are associated with neurodevelopmental disorders. Shohat S, Shifman S. Genome Res. 2019 Nov;29(11):1910-1918. doi: 10.1101/gr.250019.119. Epub 2019 Oct 24. PubMed |
| STING Restricts oHSV Replication and Spread in Resistant MPNSTs but Is Dispensable for Basal IFN-Stimulated Gene Upregulation. Lee JM, Ghonime MG, Cassady KA. Mol Ther Oncolytics. 2019 Sep 16;15:91-100. doi: 10.1016/j.omto.2019.09.001. eCollection 2019 Dec 20. PubMed |
| A centrosome-localized calcium signal is essential for mammalian cell mitosis. Helassa N, Nugues C, Rajamanoharan D, Burgoyne RD, Haynes LP. FASEB J. 2019 Dec;33(12):14602-14610. doi: 10.1096/fj.201901662R. Epub 2019 Nov 2. PubMed |
| NFE2L3 Controls Colon Cancer Cell Growth through Regulation of DUX4, a CDK1 Inhibitor. Bury M, Le Calve B, Lessard F, Dal Maso T, Saliba J, Michiels C, Ferbeyre G, Blank V. Cell Rep. 2019 Nov 5;29(6):1469-1481.e9. doi: 10.1016/j.celrep.2019.09.087. PubMed |
| Injectable, Hyaluronic Acid-Based Scaffolds with Macroporous Architecture for Gene Delivery. Ehsanipour A, Nguyen T, Aboufadel T, Sathialingam M, Cox P, Xiao W, Walthers CM, Seidlits SK. Cell Mol Bioeng. 2019 Sep 4;12(5):399-413. doi: 10.1007/s12195-019-00593-0. eCollection 2019 Oct. PubMed |
| Microparticle Depots for Controlled and Sustained Release of Endosomolytic Nanoparticles. Garland KM, Sevimli S, Kilchrist KV, Duvall CL, Cook RS, Wilson JT. Cell Mol Bioeng. 2019 May 3;12(5):429-442. doi: 10.1007/s12195-019-00571-6. eCollection 2019 Oct. PubMed |
| Control of Germinal Center Localization and Lineage Stability of Follicular Regulatory T Cells by the Blimp1 Transcription Factor. Wang L, Shen E, Luo L, Rabe H, Wang Q, Yin J, Yang X, Liu W, Sido JM, Nakagawa H, Ao L, Kim HJ, Cantor H, Leavenworth JW. Cell Rep. 2019 Nov 12;29(7):1848-1861.e6. doi: 10.1016/j.celrep.2019.10.012. PubMed |
The Leukemogenic TCF3-HLF Complex Rewires Enhancers Driving Cellular Identity and Self-Renewal Conferring EP300 Vulnerability.
Huang Y, Mouttet B, Warnatz HJ, Risch T, Rietmann F, Frommelt F, Ngo QA, Dobay MP, Marovca B, Jenni S, Tsai YC, Matzk S, Amstislavskiy V, Schrappe M, Stanulla M, Gstaiger M, Bornhauser B, Yaspo ML, Bourquin JP.
Cancer Cell. 2019 Dec 9;36(6):630-644.e9. doi: 10.1016/j.ccell.2019.10.004. Epub 2019 Nov 14.
PubMed
Associated Plasmids |
Inducible Exoc7/Exo70 knockout reveals a critical role of the exocyst in insulin-regulated GLUT4 exocytosis.
Wang S, Crisman L, Miller J, Datta I, Gulbranson DR, Tian Y, Yin Q, Yu H, Shen J.
J Biol Chem. 2019 Dec 27;294(52):19988-19996. doi: 10.1074/jbc.RA119.010821. Epub 2019 Nov 18.
PubMed
Associated Plasmids |
| A curative combination cancer therapy achieves high fractional cell killing through low cross-resistance and drug additivity. Palmer AC, Chidley C, Sorger PK. Elife. 2019 Nov 19;8. pii: 50036. doi: 10.7554/eLife.50036. PubMed |
A quantitative single-cell assay for retrograde membrane traffic enables rapid detection of defects in cellular organization.
Luong P, Li Q, Chen PF, Wrighton PJ, Chang D, Dwyer S, Bayer MT, Snapper SB, Hansen SH, Thiagarajah JT, Goessling W, Lencer WI.
Mol Biol Cell. 2019 Nov 27:mbcE19070375. doi: 10.1091/mbc.E19-07-0375.
PubMed
Associated Plasmids |
| GPR108 Is a Highly Conserved AAV Entry Factor. Dudek AM, Zabaleta N, Zinn E, Pillay S, Zengel J, Porter C, Franceschini JS, Estelien R, Carette JE, Zhou GL, Vandenberghe LH. Mol Ther. 2020 Feb 5;28(2):367-381. doi: 10.1016/j.ymthe.2019.11.005. Epub 2019 Nov 13. PubMed |
| FABP5 coordinates lipid signaling that promotes prostate cancer metastasis. Carbonetti G, Wilpshaar T, Kroonen J, Studholme K, Converso C, d'Oelsnitz S, Kaczocha M. Sci Rep. 2019 Dec 12;9(1):18944. doi: 10.1038/s41598-019-55418-x. PubMed |
| Axon-like protrusions promote small cell lung cancer migration and metastasis. Yang D, Qu F, Cai H, Chuang CH, Lim JS, Jahchan N, Gruner BM, S Kuo C, Kong C, Oudin MJ, Winslow MM, Sage J. Elife. 2019 Dec 13;8:e50616. doi: 10.7554/eLife.50616. PubMed |
| A Sensitive and Quantitative mKeima Assay for Mitophagy via FACS. Wang C. Curr Protoc Cell Biol. 2020 Mar;86(1):e99. doi: 10.1002/cpcb.99. PubMed |
| Knocking Out Multiple Genes in Cultured Primary Neurons to Study Tubulin Posttranslational Modifications. Bodakuntla S, Janke C, Magiera MM. Methods Mol Biol. 2020;2101:327-351. doi: 10.1007/978-1-0716-0219-5_19. PubMed |
| Cysteine catabolism and the serine biosynthesis pathway support pyruvate production during pyruvate kinase knockdown in pancreatic cancer cells. Yu L, Teoh ST, Ensink E, Ogrodzinski MP, Yang C, Vazquez AI, Lunt SY. Cancer Metab. 2019 Dec 30;7:13. doi: 10.1186/s40170-019-0205-z. eCollection 2019. PubMed |
| APOBEC3B reporter myeloma cell lines identify DNA damage response pathways leading to APOBEC3B expression. Yamazaki H, Shirakawa K, Matsumoto T, Kazuma Y, Matsui H, Horisawa Y, Stanford E, Sarca AD, Shirakawa R, Shindo K, Takaori-Kondo A. PLoS One. 2020 Jan 8;15(1):e0223463. doi: 10.1371/journal.pone.0223463. eCollection 2020. PubMed |
| The Roles of GSK-3beta in Regulation of Retinoid Signaling and Sorafenib Treatment Response in Hepatocellular Carcinoma. Zhang S, Gao W, Tang J, Zhang H, Zhou Y, Liu J, Chen K, Liu F, Li W, To SKY, Wong AST, Zhang XK, Zhou H, Zeng JZ. Theranostics. 2020 Jan 1;10(3):1230-1244. doi: 10.7150/thno.38711. eCollection 2020. PubMed |
| FGF13 promotes metastasis of triple-negative breast cancer. Johnstone CN, Pattison AD, Harrison PF, Powell DR, Lock P, Ernst M, Anderson RL, Beilharz TH. Int J Cancer. 2020 Jul 1;147(1):230-243. doi: 10.1002/ijc.32874. Epub 2020 Feb 24. PubMed |
| IFITM3 Reduces Retroviral Envelope Abundance and Function and Is Counteracted by glycoGag. Ahi YS, Yimer D, Shi G, Majdoul S, Rahman K, Rein A, Compton AA. mBio. 2020 Jan 21;11(1). pii: mBio.03088-19. doi: 10.1128/mBio.03088-19. PubMed |
| A Comprehensive Map of the Monocyte-Derived Dendritic Cell Transcriptional Network Engaged upon Innate Sensing of HIV. Johnson JS, De Veaux N, Rives AW, Lahaye X, Lucas SY, Perot BP, Luka M, Garcia-Paredes V, Amon LM, Watters A, Abdessalem G, Aderem A, Manel N, Littman DR, Bonneau R, Menager MM. Cell Rep. 2020 Jan 21;30(3):914-931.e9. doi: 10.1016/j.celrep.2019.12.054. PubMed |
| Generalizable sgRNA design for improved CRISPR/Cas9 editing efficiency. Hiranniramol K, Chen Y, Liu W, Wang X. Bioinformatics. 2020 May 1;36(9):2684-2689. doi: 10.1093/bioinformatics/btaa041. PubMed |
p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis.
Olivero CE, Martinez-Terroba E, Zimmer J, Liao C, Tesfaye E, Hooshdaran N, Schofield JA, Bendor J, Fang D, Simon MD, Zamudio JR, Dimitrova N.
Mol Cell. 2020 Feb 20;77(4):761-774.e8. doi: 10.1016/j.molcel.2019.12.014. Epub 2020 Jan 20.
PubMed
Associated Plasmids |
| p53 controls genomic stability and temporal differentiation of human neural stem cells and affects neural organization in human brain organoids. Marin Navarro A, Pronk RJ, van der Geest AT, Oliynyk G, Nordgren A, Arsenian-Henriksson M, Falk A, Wilhelm M. Cell Death Dis. 2020 Jan 23;11(1):52. doi: 10.1038/s41419-019-2208-7. PubMed |
| E2F-Family Members Engage the PIDDosome to Limit Hepatocyte Ploidy in Liver Development and Regeneration. Sladky VC, Knapp K, Soratroi C, Heppke J, Eichin F, Rocamora-Reverte L, Szabo TG, Bongiovanni L, Westendorp B, Moreno E, van Liere EA, Bakker B, Spierings DCJ, Wardenaar R, Pereyra D, Starlinger P, Schultze S, Trauner M, Stojakovic T, Scharnagl H, Fava LL, Foijer F, de Bruin A, Villunger A. Dev Cell. 2020 Feb 10;52(3):335-349.e7. doi: 10.1016/j.devcel.2019.12.016. Epub 2020 Jan 23. PubMed |
| c-Src Phosphorylates and Inhibits the Function of the CIC Tumor Suppressor Protein. Bunda S, Heir P, Li ASC, Mamatjan Y, Zadeh G, Aldape K. Mol Cancer Res. 2020 May;18(5):774-786. doi: 10.1158/1541-7786.MCR-18-1370. Epub 2020 Feb 6. PubMed |
| Delete_Genetic screens in isogenic mammalian cell lines without single cell cloning. DeWeirdt PC, Sangree AK, Hanna RE, Sanson KR, Hegde M, Strand C, Persky NS, Doench JG. Nat Commun. 2020 Feb 6;11(1):752. doi: 10.1038/s41467-020-14620-6. PubMed |
| Imprinted Maternally Expressed microRNAs Antagonize Paternally Driven Gene Programs in Neurons. Whipple AJ, Breton-Provencher V, Jacobs HN, Chitta UK, Sur M, Sharp PA. Mol Cell. 2020 Apr 2;78(1):85-95.e8. doi: 10.1016/j.molcel.2020.01.020. Epub 2020 Feb 6. PubMed |
| The ACSL3-LPIAT1 signaling drives prostaglandin synthesis in non-small cell lung cancer. Saliakoura M, Reynoso-Moreno I, Pozzato C, Rossi Sebastiano M, Galie M, Gertsch J, Konstantinidou G. Oncogene. 2020 Apr;39(14):2948-2960. doi: 10.1038/s41388-020-1196-5. Epub 2020 Feb 7. PubMed |
| CellTagging: combinatorial indexing to simultaneously map lineage and identity at single-cell resolution. Kong W, Biddy BA, Kamimoto K, Amrute JM, Butka EG, Morris SA. Nat Protoc. 2020 Mar;15(3):750-772. doi: 10.1038/s41596-019-0247-2. Epub 2020 Feb 12. PubMed |
| Iridoids of Valeriana fauriei contribute to alleviating hepatic steatosis in obese mice by lipophagy. Lee DH, Park SH, Huh YH, Jung Kim M, Seo HD, Ha TY, Ahn J, Jang YJ, Jung CH. Biomed Pharmacother. 2020 May;125:109950. doi: 10.1016/j.biopha.2020.109950. Epub 2020 Feb 10. PubMed |
Chemogenetic Control of Nanobodies.
Farrants H, Tarnawski M, Muller TG, Otsuka S, Hiblot J, Koch B, Kueblbeck M, Krausslich HG, Ellenberg J, Johnsson K.
Nat Methods. 2020 Feb 17. pii: 10.1038/s41592-020-0746-7. doi: 10.1038/s41592-020-0746-7.
PubMed
Associated Plasmids |
| CtBP1-Mediated Membrane Fission Contributes to Effective Recycling of Synaptic Vesicles. Ivanova D, Imig C, Camacho M, Reinhold A, Guhathakurta D, Montenegro-Venegas C, Cousin MA, Gundelfinger ED, Rosenmund C, Cooper B, Fejtova A. Cell Rep. 2020 Feb 18;30(7):2444-2459.e7. doi: 10.1016/j.celrep.2020.01.079. PubMed |
| Functional angiogenesis requires microenvironmental cues balancing endothelial cell migration and proliferation. Wang WY, Lin D, Jarman EH, Polacheck WJ, Baker BM. Lab Chip. 2020 Mar 17;20(6):1153-1166. doi: 10.1039/c9lc01170f. PubMed |
| KLF16 Affects the MYC Signature and Tumor Growth in Prostate Cancer. Zhang J, Yu W, Wang X, Hu B, Wu D, Shi G. Onco Targets Ther. 2020 Feb 13;13:1303-1310. doi: 10.2147/OTT.S233495. eCollection 2020. PubMed |
| Vimentin Coordinates Protein Turnover at the Aggresome during Neural Stem Cell Quiescence Exit. Morrow CS, Porter TJ, Xu N, Arndt ZP, Ako-Asare K, Heo HJ, Thompson EAN, Moore DL. Cell Stem Cell. 2020 Apr 2;26(4):558-568.e9. doi: 10.1016/j.stem.2020.01.018. Epub 2020 Feb 27. PubMed |
| Acute knockdown of Depdc5 leads to synaptic defects in mTOR-related epileptogenesis. De Fusco A, Cerullo MS, Marte A, Michetti C, Romei A, Castroflorio E, Baulac S, Benfenati F. Neurobiol Dis. 2020 Jun;139:104822. doi: 10.1016/j.nbd.2020.104822. Epub 2020 Feb 27. PubMed |
Accurate and live peroxisome biogenesis evaluation achieved by lentiviral expression of a green fluorescent protein fused to a peroxisome targeting signal 1.
Demaret T, Courtoy GE, Ravau J, Van Der Smissen P, Najimi M, Sokal EM.
Histochem Cell Biol. 2020 Mar 2. pii: 10.1007/s00418-020-01855-z. doi: 10.1007/s00418-020-01855-z.
PubMed
Associated Plasmids |
| JC Virus infected choroid plexus epithelial cells produce extracellular vesicles that infect glial cells independently of the virus attachment receptor. O'Hara BA, Morris-Love J, Gee GV, Haley SA, Atwood WJ. PLoS Pathog. 2020 Mar 4;16(3):e1008371. doi: 10.1371/journal.ppat.1008371. eCollection 2020 Mar. PubMed |
| Prioritizing disease and trait causal variants at the TNFAIP3 locus using functional and genomic features. Ray JP, de Boer CG, Fulco CP, Lareau CA, Kanai M, Ulirsch JC, Tewhey R, Ludwig LS, Reilly SK, Bergman DT, Engreitz JM, Issner R, Finucane HK, Lander ES, Regev A, Hacohen N. Nat Commun. 2020 Mar 6;11(1):1237. doi: 10.1038/s41467-020-15022-4. PubMed |
| Biallelic loss of FAM46C triggers tumor growth with concomitant activation of Akt signaling in multiple myeloma cells. Kanasugi J, Hanamura I, Ota A, Karnan S, Lam VQ, Mizuno S, Wahiduzzaman M, Rahman ML, Hyodo T, Konishi H, Tsuzuki S, Hosokawa Y, Takami A. Cancer Sci. 2020 May;111(5):1663-1675. doi: 10.1111/cas.14386. Epub 2020 Apr 9. PubMed |
| Improved detection of differentially represented DNA barcodes for high-throughput clonal phenomics. Akimov Y, Bulanova D, Timonen S, Wennerberg K, Aittokallio T. Mol Syst Biol. 2020 Mar;16(3):e9195. doi: 10.15252/msb.20199195. PubMed |
| Nicotinamide nucleotide transhydrogenase regulates mitochondrial metabolism in NSCLC through maintenance of Fe-S protein function. Ward NP, Kang YP, Falzone A, Boyle TA, DeNicola GM. J Exp Med. 2020 Jun 1;217(6). pii: 151572. doi: 10.1084/jem.20191689. PubMed |
| Phosphorylated Lamin A/C in the Nuclear Interior Binds Active Enhancers Associated with Abnormal Transcription in Progeria. Ikegami K, Secchia S, Almakki O, Lieb JD, Moskowitz IP. Dev Cell. 2020 Mar 23;52(6):699-713.e11. doi: 10.1016/j.devcel.2020.02.011. PubMed |
| Smooth Muscle Cell Reprogramming in Aortic Aneurysms. Chen PY, Qin L, Li G, Malagon-Lopez J, Wang Z, Bergaya S, Gujja S, Caulk AW, Murtada SI, Zhang X, Zhuang ZW, Rao DA, Wang G, Tobiasova Z, Jiang B, Montgomery RR, Sun L, Sun H, Fisher EA, Gulcher JR, Fernandez-Hernando C, Humphrey JD, Tellides G, Chittenden TW, Simons M. Cell Stem Cell. 2020 Apr 2;26(4):542-557.e11. doi: 10.1016/j.stem.2020.02.013. PubMed |
| Complement-Independent Modulation of Influenza A Virus Infection by Factor H. Murugaiah V, Varghese PM, Saleh SM, Tsolaki AG, Alrokayan SH, Khan HA, Collison KS, Sim RB, Nal B, Al-Mohanna FA, Kishore U. Front Immunol. 2020 Mar 25;11:355. doi: 10.3389/fimmu.2020.00355. eCollection 2020. PubMed |
| Salmonella enterica Infection of Murine and Human Enteroid-Derived Monolayers Elicits Differential Activation of Epithelium-Intrinsic Inflammasomes. Holly MK, Han X, Zhao EJ, Crowley SM, Allaire JM, Knodler LA, Vallance BA, Smith JG. Infect Immun. 2020 Jun 22;88(7):e00017-20. doi: 10.1128/IAI.00017-20. Print 2020 Jun 22. PubMed |
| Inhibition of collagen XI alpha 1-induced fatty acid oxidation triggers apoptotic cell death in cisplatin-resistant ovarian cancer. Nallanthighal S, Rada M, Heiserman JP, Cha J, Sage J, Zhou B, Yang W, Hu Y, Korgaonkar C, Hanos CT, Ashkavand Z, Norman K, Orsulic S, Cheon DJ. Cell Death Dis. 2020 Apr 20;11(4):258. doi: 10.1038/s41419-020-2442-z. PubMed |
| HIGD2A is Required for Assembly of the COX3 Module of Human Mitochondrial Complex IV. Hock DH, Reljic B, Ang CS, Muellner-Wong L, Mountford HS, Compton AG, Ryan MT, Thorburn DR, Stroud DA. Mol Cell Proteomics. 2020 Jul;19(7):1145-1160. doi: 10.1074/mcp.RA120.002076. Epub 2020 Apr 21. PubMed |
| CtBP determines ovarian cancer cell fate through repression of death receptors. Ding B, Yuan F, Damle PK, Litovchick L, Drapkin R, Grossman SR. Cell Death Dis. 2020 Apr 24;11(4):286. doi: 10.1038/s41419-020-2455-7. PubMed |
| Trichoplein binds PCM1 and controls endothelial cell function by regulating autophagy. Martello A, Lauriola A, Mellis D, Parish E, Dawson JC, Imrie L, Vidmar M, Gammoh N, Mitic T, Brittan M, Mills NL, Carragher NO, D'Arca D, Caporali A. EMBO Rep. 2020 Jul 3;21(7):e48192. doi: 10.15252/embr.201948192. Epub 2020 Apr 26. PubMed |
| Nelfinavir Inhibits the TCF11/Nrf1-Mediated Proteasome Recovery Pathway in Multiple Myeloma. Fassmannova D, Sedlak F, Sedlacek J, Spicka I, Grantz Saskova K. Cancers (Basel). 2020 Apr 25;12(5). pii: cancers12051065. doi: 10.3390/cancers12051065. PubMed |
| Inhibition of Tumor VEGFR2 Induces Serine 897 EphA2-Dependent Tumor Cell Invasion and Metastasis in NSCLC. Volz C, Breid S, Selenz C, Zaplatina A, Golfmann K, Meder L, Dietlein F, Borchmann S, Chatterjee S, Siobal M, Schottle J, Florin A, Koker M, Nill M, Ozretic L, Uhlenbrock N, Smith S, Buttner R, Miao H, Wang B, Reinhardt HC, Rauh D, Hallek M, Acker-Palmer A, Heukamp LC, Ullrich RT. Cell Rep. 2020 Apr 28;31(4):107568. doi: 10.1016/j.celrep.2020.107568. PubMed |
| BCL9/STAT3 regulation of transcriptional enhancer networks promote DCIS progression. Elsarraj HS, Hong Y, Limback D, Zhao R, Berger J, Bishop SC, Sabbagh A, Oppenheimer L, Harper HE, Tsimelzon A, Huang S, Hilsenbeck SG, Edwards DP, Fontes J, Fan F, Madan R, Fangman B, Ellis A, Tawfik O, Persons DL, Fields T, Godwin AK, Hagan CR, Swenson-Fields K, Coarfa C, Thompson J, Behbod F. NPJ Breast Cancer. 2020 Apr 24;6:12. doi: 10.1038/s41523-020-0157-z. eCollection 2020. PubMed |
| Photoactivatable Cre recombinase 3.0 for in vivo mouse applications. Morikawa K, Furuhashi K, de Sena-Tomas C, Garcia-Garcia AL, Bekdash R, Klein AD, Gallerani N, Yamamoto HE, Park SE, Collins GS, Kawano F, Sato M, Lin CS, Targoff KL, Au E, Salling MC, Yazawa M. Nat Commun. 2020 May 1;11(1):2141. doi: 10.1038/s41467-020-16030-0. PubMed |
| Formate induces a metabolic switch in nucleotide and energy metabolism. Oizel K, Tait-Mulder J, Fernandez-de-Cossio-Diaz J, Pietzke M, Brunton H, Lilla S, Dhayade S, Athineos D, Blanco GR, Sumpton D, Mackay GM, Blyth K, Zanivan SR, Meiser J, Vazquez A. Cell Death Dis. 2020 May 4;11(5):310. doi: 10.1038/s41419-020-2523-z. PubMed |
| Epithelial cell -derived microvesicles: A safe delivery platform of CRISPR/Cas9 conferring synergistic anti-tumor effect with sorafenib. He C, Jaffar Ali D, Xu H, Kumaravel S, Si K, Li Y, Sun B, Ma J, Xiao Z. Exp Cell Res. 2020 Jul 15;392(2):112040. doi: 10.1016/j.yexcr.2020.112040. Epub 2020 May 4. PubMed |
| A homozygous variant in NDUFA8 is associated with developmental delay, microcephaly, and epilepsy due to mitochondrial complex I deficiency. Yatsuka Y, Kishita Y, Formosa LE, Shimura M, Nozaki F, Fujii T, Nitta KR, Ohtake A, Murayama K, Ryan MT, Okazaki Y. Clin Genet. 2020 Aug;98(2):155-165. doi: 10.1111/cge.13773. Epub 2020 May 25. PubMed |
| Blockade of Oncogenic NOTCH1 with the SERCA Inhibitor CAD204520 in T Cell Acute Lymphoblastic Leukemia. Marchesini M, Gherli A, Montanaro A, Patrizi L, Sorrentino C, Pagliaro L, Rompietti C, Kitara S, Heit S, Olesen CE, Moller JV, Savi M, Bocchi L, Vilella R, Rizzi F, Baglione M, Rastelli G, Loiacono C, La Starza R, Mecucci C, Stegmaier K, Aversa F, Stilli D, Lund Winther AM, Sportoletti P, Bublitz M, Dalby-Brown W, Roti G. Cell Chem Biol. 2020 Jun 18;27(6):678-697.e13. doi: 10.1016/j.chembiol.2020.04.002. Epub 2020 May 7. PubMed |
| Auxiliary alpha2delta1 and alpha2delta3 Subunits of Calcium Channels Drive Excitatory and Inhibitory Neuronal Network Development. Bikbaev A, Ciuraszkiewicz-Wojciech A, Heck J, Klatt O, Freund R, Mitlohner J, Enrile Lacalle S, Sun M, Repetto D, Frischknecht R, Ablinger C, Rohlmann A, Missler M, Obermair GJ, Di Biase V, Heine M. J Neurosci. 2020 Jun 17;40(25):4824-4841. doi: 10.1523/JNEUROSCI.1707-19.2020. Epub 2020 May 15. PubMed |
| Stress-induced TRAILR2 expression overcomes TRAIL resistance in cancer cell spheroids. Stohr D, Schmid JO, Beigl TB, Mack A, Maichl DS, Cao K, Budai B, Fullstone G, Kontermann RE, Murdter TE, Tait SWG, Hagenlocher C, Pollak N, Scheurich P, Rehm M. Cell Death Differ. 2020 May 20. pii: 10.1038/s41418-020-0559-3. doi: 10.1038/s41418-020-0559-3. PubMed |
| SETD5-Coordinated Chromatin Reprogramming Regulates Adaptive Resistance to Targeted Pancreatic Cancer Therapy. Wang Z, Hausmann S, Lyu R, Li TM, Lofgren SM, Flores NM, Fuentes ME, Caporicci M, Yang Z, Meiners MJ, Cheek MA, Howard SA, Zhang L, Elias JE, Kim MP, Maitra A, Wang H, Bassik MC, Keogh MC, Sage J, Gozani O, Mazur PK. Cancer Cell. 2020 Jun 8;37(6):834-849.e13. doi: 10.1016/j.ccell.2020.04.014. Epub 2020 May 21. PubMed |
| Generation of a human iPSC line (MPIi006-A) from a patient with Pelizaeus-Merzbacher disease. Kim KP, Yoon J, Shin B, Ropke A, Han DW, Scholer HR. Stem Cell Res. 2020 Jul;46:101839. doi: 10.1016/j.scr.2020.101839. Epub 2020 May 7. PubMed |
| MYC Drives Temporal Evolution of Small Cell Lung Cancer Subtypes by Reprogramming Neuroendocrine Fate. Ireland AS, Micinski AM, Kastner DW, Guo B, Wait SJ, Spainhower KB, Conley CC, Chen OS, Guthrie MR, Soltero D, Qiao Y, Huang X, Tarapcsak S, Devarakonda S, Chalishazar MD, Gertz J, Moser JC, Marth G, Puri S, Witt BL, Spike BT, Oliver TG. Cancer Cell. 2020 Jul 13;38(1):60-78.e12. doi: 10.1016/j.ccell.2020.05.001. Epub 2020 May 30. PubMed |
| Mitochondrial AIF loss causes metabolic reprogramming, caspase-independent cell death blockade, embryonic lethality, and perinatal hydrocephalus. Delavallee L, Mathiah N, Cabon L, Mazeraud A, Brunelle-Navas MN, Lerner LK, Tannoury M, Prola A, Moreno-Loshuertos R, Baritaud M, Vela L, Garbin K, Garnier D, Lemaire C, Langa-Vives F, Cohen-Salmon M, Fernandez-Silva P, Chretien F, Migeotte I, Susin SA. Mol Metab. 2020 May 30;40:101027. doi: 10.1016/j.molmet.2020.101027. PubMed |
| Expression profiles and function of IL6 in polymorphonuclear myeloid-derived suppressor cells. Ibrahim ML, Lu C, Klement JD, Redd PS, Yang D, Smith AD, Liu K. Cancer Immunol Immunother. 2020 Jun 1. pii: 10.1007/s00262-020-02620-w. doi: 10.1007/s00262-020-02620-w. PubMed |
| m(6)A Modification Prevents Formation of Endogenous Double-Stranded RNAs and Deleterious Innate Immune Responses during Hematopoietic Development. Gao Y, Vasic R, Song Y, Teng R, Liu C, Gbyli R, Biancon G, Nelakanti R, Lobben K, Kudo E, Liu W, Ardasheva A, Fu X, Wang X, Joshi P, Lee V, Dura B, Viero G, Iwasaki A, Fan R, Xiao A, Flavell RA, Li HB, Tebaldi T, Halene S. Immunity. 2020 Jun 16;52(6):1007-1021.e8. doi: 10.1016/j.immuni.2020.05.003. Epub 2020 Jun 3. PubMed |
| Endolysosomal Targeting of Mitochondria Is Integral to BAX-Mediated Mitochondrial Permeabilization during Apoptosis Signaling. Wang TS, Coppens I, Saorin A, Brady NR, Hamacher-Brady A. Dev Cell. 2020 Jun 22;53(6):627-645.e7. doi: 10.1016/j.devcel.2020.05.014. Epub 2020 Jun 5. PubMed |
Cell Type-Specific In Vitro Gene Expression Profiling of Stem Cell-Derived Neural Models.
Gregory JA, Hoelzli E, Abdelaal R, Braine C, Cuevas M, Halpern M, Barretto N, Schrode N, Akbalik G, Kang K, Cheng E, Bowles K, Lotz S, Goderie S, Karch CM, Temple S, Goate A, Brennand KJ, Phatnani H.
Cells. 2020 Jun 5;9(6). pii: cells9061406. doi: 10.3390/cells9061406.
PubMed
Associated Plasmids |
| Failed Apoptosis Enhances Melanoma Cancer Cell Aggressiveness. Berthenet K, Castillo Ferrer C, Fanfone D, Popgeorgiev N, Neves D, Bertolino P, Gibert B, Hernandez-Vargas H, Ichim G. Cell Rep. 2020 Jun 9;31(10):107731. doi: 10.1016/j.celrep.2020.107731. PubMed |
| Loss of STAT6 leads to anchorage-independent growth and trastuzumab resistance in HER2+ breast cancer cells. DiScala M, Najor MS, Yung T, Morgan D, Abukhdeir AM, Cobleigh MA. PLoS One. 2020 Jun 11;15(6):e0234146. doi: 10.1371/journal.pone.0234146. eCollection 2020. PubMed |
| PHGDH supports liver ceramide synthesis and sustains lipid homeostasis. Kang YP, Falzone A, Liu M, Gonzalez-Sanchez P, Choi BH, Coloff JL, Saller JJ, Karreth FA, DeNicola GM. Cancer Metab. 2020 Jun 15;8:6. doi: 10.1186/s40170-020-00212-x. eCollection 2020. PubMed |
| PDGFRbeta plays an essential role in patient vitreous-stimulated contraction of retinal pigment epithelial cells from epiretinal membranes. Yang Y, Huang X, Ma G, Cui J, Matsubara JA, Kazlauskas A, Zhao J, Wang J, Lei H. Exp Eye Res. 2020 Aug;197:108116. doi: 10.1016/j.exer.2020.108116. Epub 2020 Jun 16. PubMed |
| Sequentially induced motor neurons from human fibroblasts facilitate locomotor recovery in a rodent spinal cord injury model. Lee H, Lee HY, Lee BE, Gerovska D, Park SY, Zaehres H, Arauzo-Bravo MJ, Kim JI, Ha Y, Scholer HR, Kim JB. Elife. 2020 Jun 23;9. pii: 52069. doi: 10.7554/eLife.52069. PubMed |
| Regulation of Cas9 by viral proteins Tat and Rev for HIV-1 inactivation. Vergara-Mendoza M, Gomez-Quiroz LE, Miranda-Labra RU, Fuentes-Romero LL, Romero-Rodriguez DP, Gonzalez-Ruiz J, Hernandez-Rizo S, Viveros-Rogel M. Antiviral Res. 2020 Aug;180:104856. doi: 10.1016/j.antiviral.2020.104856. Epub 2020 Jun 21. PubMed |
| Recognition of Semaphorin Proteins by P. sordellii Lethal Toxin Reveals Principles of Receptor Specificity in Clostridial Toxins. Lee H, Beilhartz GL, Kucharska I, Raman S, Cui H, Lam MHY, Liang H, Rubinstein JL, Schramek D, Julien JP, Melnyk RA, Taipale M. Cell. 2020 Jul 23;182(2):345-356.e16. doi: 10.1016/j.cell.2020.06.005. Epub 2020 Jun 25. PubMed |
| Y Chromosome LncRNA are involved in Radiation Response of Male Non-Small Cell Lung Cancer Cells. Brownmiller T, Juric JA, Ivey AD, Harvey BM, Westemeier ES, Winters MT, Stevens AM, Stanley AN, Hayes KE, Sprowls SA, Gatesman Ammer AS, Walker M, Bey EA, Wu X, Lim ZF, Zhu L, Wen S, Hu G, Ma PC, Martinez I. Cancer Res. 2020 Jul 2. pii: 0008-5472.CAN-19-4032. doi: 10.1158/0008-5472.CAN-19-4032. PubMed |
| TBL1XR1 Mutations Drive Extranodal Lymphoma by Inducing a Pro-tumorigenic Memory Fate. Venturutti L, Teater M, Zhai A, Chadburn A, Babiker L, Kim D, Beguelin W, Lee TC, Kim Y, Chin CR, Yewdell WT, Raught B, Phillip JM, Jiang Y, Staudt LM, Green MR, Chaudhuri J, Elemento O, Farinha P, Weng AP, Nissen MD, Steidl C, Morin RD, Scott DW, Prive GG, Melnick AM. Cell. 2020 Jul 23;182(2):297-316.e27. doi: 10.1016/j.cell.2020.05.049. Epub 2020 Jul 2. PubMed |
| Evaluation of an aldo-keto reductase gene signature with prognostic significance in colon cancer via activation of epithelial to mesenchymal transition and the p70S6K pathway. Demirkol Canli S, Seza EG, Sheraj I, Gomceli I, Turhan N, Carberry S, Prehn JHM, Gure AO, Banerjee S. Carcinogenesis. 2020 Jul 6. pii: 5867997. doi: 10.1093/carcin/bgaa072. PubMed |
| Cancer Stem Cell-Inducing Media Activates Senescence Reprogramming in Fibroblasts. Perrigue PM, Rakoczy M, Pawlicka KP, Belter A, Giel-Pietraszuk M, Naskret-Barciszewska M, Barciszewski J, Figlerowicz M. Cancers (Basel). 2020 Jun 30;12(7). pii: cancers12071745. doi: 10.3390/cancers12071745. PubMed |
| CCN1/Cyr61 is required in osteoblasts for responsiveness to the anabolic activity of PTH. Zhao G, Kim EW, Jiang J, Bhoot C, Charles KR, Baek J, Mohan S, Adams JS, Tetradis S, Lyons KM. J Bone Miner Res. 2020 Jul 7. doi: 10.1002/jbmr.4128. PubMed |
| Mutant p53 Drives Cancer Metastasis via RCP-Mediated Hsp90alpha Secretion. Zhang S, Wang C, Ma B, Xu M, Xu S, Liu J, Tian Y, Fu Y, Luo Y. Cell Rep. 2020 Jul 7;32(1):107879. doi: 10.1016/j.celrep.2020.107879. PubMed |
| Immunogenomic Landscape of Hematological Malignancies. Dufva O, Polonen P, Bruck O, Keranen MAI, Klievink J, Mehtonen J, Huuhtanen J, Kumar A, Malani D, Siitonen S, Kankainen M, Ghimire B, Lahtela J, Mattila P, Vaha-Koskela M, Wennerberg K, Granberg K, Leivonen SK, Meriranta L, Heckman C, Leppa S, Nykter M, Lohi O, Heinaniemi M, Mustjoki S. Cancer Cell. 2020 Sep 14;38(3):380-399.e13. doi: 10.1016/j.ccell.2020.06.002. Epub 2020 Jul 9. PubMed |
| A Three-Dimensional Alzheimer's Disease Cell Culture Model Using iPSC-Derived Neurons Carrying A246E Mutation in PSEN1. Hernandez-Sapiens MA, Reza-Zaldivar EE, Cevallos RR, Marquez-Aguirre AL, Gazarian K, Canales-Aguirre AA. Front Cell Neurosci. 2020 Jun 12;14:151. doi: 10.3389/fncel.2020.00151. eCollection 2020. PubMed |
| MEIS1 down-regulation by MYC mediates prostate cancer development through elevated HOXB13 expression and AR activity. Whitlock NC, Trostel SY, Wilkinson S, Terrigino NT, Hennigan ST, Lake R, Carrabba NV, Atway R, Walton ED, Gryder BE, Capaldo BJ, Ye H, Sowalsky AG. Oncogene. 2020 Aug;39(34):5663-5674. doi: 10.1038/s41388-020-01389-7. Epub 2020 Jul 17. PubMed |
| Tracking cells in epithelial acini by light sheet microscopy reveals proximity effects in breast cancer initiation. Alladin A, Chaible L, Garcia Del Valle L, Sabine R, Loeschinger M, Wachsmuth M, Heriche JK, Tischer C, Jechlinger M. Elife. 2020 Jul 21;9. pii: 54066. doi: 10.7554/eLife.54066. PubMed |
| Cohesin-Dependent and -Independent Mechanisms Mediate Chromosomal Contacts between Promoters and Enhancers. Thiecke MJ, Wutz G, Muhar M, Tang W, Bevan S, Malysheva V, Stocsits R, Neumann T, Zuber J, Fraser P, Schoenfelder S, Peters JM, Spivakov M. Cell Rep. 2020 Jul 21;32(3):107929. doi: 10.1016/j.celrep.2020.107929. PubMed |
| TRPV4 Inhibition and CRISPR-Cas9 Knockout Reduce Inflammation Induced by Hyperphysiological Stretching in Human Annulus Fibrosus Cells. Cambria E, Arlt MJE, Wandel S, Krupkova O, Hitzl W, Passini FS, Hausmann ON, Snedeker JG, Ferguson SJ, Wuertz-Kozak K. Cells. 2020 Jul 21;9(7). pii: cells9071736. doi: 10.3390/cells9071736. PubMed |
| Essential Functions of Glycans in Human Epithelia Dissected by a CRISPR-Cas9-Engineered Human Organotypic Skin Model. Dabelsteen S, Pallesen EMH, Marinova IN, Nielsen MI, Adamopoulou M, Romer TB, Levann A, Andersen MM, Ye Z, Thein D, Bennett EP, Bull C, Moons SJ, Boltje T, Clausen H, Vakhrushev SY, Bagdonaite I, Wandall HH. Dev Cell. 2020 Sep 14;54(5):669-684.e7. doi: 10.1016/j.devcel.2020.06.039. Epub 2020 Jul 24. PubMed |
| Design and Evaluation of AgoshRNAs with 3'-Terminal HDV Ribozymes to Enhance the Silencing Activity. Berkhout B, Herrera-Carrillo E. Methods Mol Biol. 2021;2167:225-252. doi: 10.1007/978-1-0716-0716-9_13. PubMed |
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| An Optimized Protocol for Human Direct Cardiac Reprogramming. Garbutt TA, Zhou Y, Keepers B, Liu J, Qian L. STAR Protoc. 2020 Jun 19;1(1). doi: 10.1016/j.xpro.2019.100010. Epub 2020 Jun 3. PubMed |
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| A Replication-Competent Vesicular Stomatitis Virus for Studies of SARS-CoV-2 Spike-Mediated Cell Entry and Its Inhibition. Dieterle ME, Haslwanter D, Bortz RH 3rd, Wirchnianski AS, Lasso G, Vergnolle O, Abbasi SA, Fels JM, Laudermilch E, Florez C, Mengotto A, Kimmel D, Malonis RJ, Georgiev G, Quiroz J, Barnhill J, Pirofski LA, Daily JP, Dye JM, Lai JR, Herbert AS, Chandran K, Jangra RK. Cell Host Microbe. 2020 Sep 9;28(3):486-496.e6. doi: 10.1016/j.chom.2020.06.020. Epub 2020 Jul 3. PubMed |
| Dynamic chromatin accessibility landscape changes following interleukin-1 stimulation. Barter MJ, Cheung K, Falk J, Panagiotopoulos AC, Cosimini C, O'Brien S, Teja-Putri K, Neill G, Deehan DJ, Young DA. Epigenetics. 2021 Jan;16(1):106-119. doi: 10.1080/15592294.2020.1789266. Epub 2020 Aug 2. PubMed |
| Preclinical Assessment of Efficacy and Safety Analysis of CAR-T Cells (ISIKOK-19) Targeting CD19-Expressing B-Cells for the First Turkish Academic Clinical Trial with Relapsed/Refractory ALL and NHL Patients Tastan C, Kancagi DD, Turan RD, Yurtsever B, Cakirsoy D, Abanuz S, Yilanci M, Seyis U, Ozer S, Mert S, Kayhan CK, Tokat F, Acikel Elmas M, Birdogan S, Arbak S, Yalcin K, Sezgin A, Kizilkilic E, Hemsinlioglu C, Ince U, Ratip S, Ovali E. Turk J Haematol. 2020 Nov 19;37(4):234-247. doi: 10.4274/tjh.galenos.2020.2020.0070. Epub 2020 Aug 4. PubMed |
| Inhibition of MEK1/2 Forestalls the Onset of Acquired Resistance to Entrectinib in Multiple Models of NTRK1-Driven Cancer. Vaishnavi A, Scherzer MT, Kinsey CG, Parkman GL, Truong A, Ghazi P, Schuman S, Battistone B, Garrido-Laguna I, McMahon M. Cell Rep. 2020 Aug 4;32(5):107994. doi: 10.1016/j.celrep.2020.107994. PubMed |
| Genome-Wide Screens Reveal that Resveratrol Induces Replicative Stress in Human Cells. Benslimane Y, Bertomeu T, Coulombe-Huntington J, McQuaid M, Sanchez-Osuna M, Papadopoli D, Avizonis D, Russo MST, Huard C, Topisirovic I, Wurtele H, Tyers M, Harrington L. Mol Cell. 2020 Sep 3;79(5):846-856.e8. doi: 10.1016/j.molcel.2020.07.010. Epub 2020 Aug 4. PubMed |
| Generation of two iPS cell lines (HIHDNDi001-A and HIHDNDi001-B) from a Parkinson's disease patient carrying the heterozygous p.A30P mutation in SNCA. Barbuti PA, Santos BFR, Dording CM, Cruciani G, Massart F, Hummel A, Kruger R. Stem Cell Res. 2020 Oct;48:101951. doi: 10.1016/j.scr.2020.101951. Epub 2020 Aug 8. PubMed |
| SUMOylation of E2F1 Regulates Expression of EZH2. Du L, Fakih MG, Rosen ST, Chen Y. Cancer Res. 2020 Oct 1;80(19):4212-4223. doi: 10.1158/0008-5472.CAN-20-1259. Epub 2020 Aug 14. PubMed |
| Genetic evidence for an inhibitory role of tomosyn in insulin-stimulated GLUT4 exocytosis. Wang S, Liu Y, Crisman L, Wan C, Miller J, Yu H, Shen J. Traffic. 2020 Oct;21(10):636-646. doi: 10.1111/tra.12760. PubMed |
| An Excitable Ras/PI3K/ERK Signaling Network Controls Migration and Oncogenic Transformation in Epithelial Cells. Zhan H, Bhattacharya S, Cai H, Iglesias PA, Huang CH, Devreotes PN. Dev Cell. 2020 Sep 14;54(5):608-623.e5. doi: 10.1016/j.devcel.2020.08.001. Epub 2020 Sep 1. PubMed |
| Generation of a human iPSC line (MPIi007-A) from a patient with Metachromatic leukodystrophy. Kim KP, Yoon J, Kim J, Ropke A, Shin B, Wook Han D, Greber B, Scholer HR. Stem Cell Res. 2020 Oct;48:101993. doi: 10.1016/j.scr.2020.101993. Epub 2020 Sep 13. PubMed |
| Quantitative in vivo bioluminescence imaging of orthotopic patient-derived glioblastoma xenografts. Koessinger AL, Koessinger D, Stevenson K, Cloix C, Mitchell L, Nixon C, Gomez-Roman N, Chalmers AJ, Norman JC, Tait SWG. Sci Rep. 2020 Sep 21;10(1):15361. doi: 10.1038/s41598-020-72322-x. PubMed |
| Tumor suppressive function of Matrin 3 in the basal-like breast cancer. Yang J, Lee SJ, Kwon Y, Ma L, Kim J. Biol Res. 2020 Sep 25;53(1):42. doi: 10.1186/s40659-020-00310-6. PubMed |
| A Global Map of G Protein Signaling Regulation by RGS Proteins. Masuho I, Balaji S, Muntean BS, Skamangas NK, Chavali S, Tesmer JJG, Babu MM, Martemyanov KA. Cell. 2020 Oct 15;183(2):503-521.e19. doi: 10.1016/j.cell.2020.08.052. Epub 2020 Oct 1. PubMed |
| A novel co-culture assay to assess anti-tumor CD8(+) T cell cytotoxicity via luminescence and multicolor flow cytometry. Olivo Pimentel V, Yaromina A, Marcus D, Dubois LJ, Lambin P. J Immunol Methods. 2020 Dec;487:112899. doi: 10.1016/j.jim.2020.112899. Epub 2020 Oct 15. PubMed |
| PLCgamma1 suppression promotes the adaptation of KRAS-mutant lung adenocarcinomas to hypoxia. Saliakoura M, Rossi Sebastiano M, Pozzato C, Heidel FH, Schnoder TM, Savic Prince S, Bubendorf L, Pinton P, A Schmid R, Baumgartner J, Freigang S, Berezowska SA, Rimessi A, Konstantinidou G. Nat Cell Biol. 2020 Nov;22(11):1382-1395. doi: 10.1038/s41556-020-00592-8. Epub 2020 Oct 19. PubMed |
| Cetuximab-Mediated Protection from Hypoxia- Induced Cell Death: Implications for Therapy Sequence in Colorectal Cancer. Urban H, Maurer GD, Luger AL, Lorenz NI, Sauer B, Stroh C, Trojan J, Mittelbronn M, Steinbach JP, Harter PN, Ronellenfitsch MW. Cancers (Basel). 2020 Oct 20;12(10):3050. doi: 10.3390/cancers12103050. PubMed |
| Receptor-Driven ERK Pulses Reconfigure MAPK Signaling and Enable Persistence of Drug-Adapted BRAF-Mutant Melanoma Cells. Gerosa L, Chidley C, Frohlich F, Sanchez G, Lim SK, Muhlich J, Chen JY, Vallabhaneni S, Baker GJ, Schapiro D, Atanasova MI, Chylek LA, Shi T, Yi L, Nicora CD, Claas A, Ng TSC, Kohler RH, Lauffenburger DA, Weissleder R, Miller MA, Qian WJ, Wiley HS, Sorger PK. Cell Syst. 2020 Nov 18;11(5):478-494.e9. doi: 10.1016/j.cels.2020.10.002. Epub 2020 Oct 27. PubMed |
Role of Aberrant Spontaneous Neurotransmission in SNAP25-Associated Encephalopathies.
Alten B, Zhou Q, Shin OH, Esquivies L, Lin PY, White KI, Sun R, Chung WK, Monteggia LM, Brunger AT, Kavalali ET.
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Genome-wide CRISPR Screens Reveal Host Factors Critical for SARS-CoV-2 Infection.
Wei J, Alfajaro MM, DeWeirdt PC, Hanna RE, Lu-Culligan WJ, Cai WL, Strine MS, Zhang SM, Graziano VR, Schmitz CO, Chen JS, Mankowski MC, Filler RB, Ravindra NG, Gasque V, de Miguel FJ, Patil A, Chen H, Oguntuyo KY, Abriola L, Surovtseva YV, Orchard RC, Lee B, Lindenbach BD, Politi K, van Dijk D, Kadoch C, Simon MD, Yan Q, Doench JG, Wilen CB.
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| Drp1 Tubulates the ER in a GTPase-Independent Manner. Adachi Y, Kato T, Yamada T, Murata D, Arai K, Stahelin RV, Chan DC, Iijima M, Sesaki H. Mol Cell. 2020 Nov 19;80(4):621-632.e6. doi: 10.1016/j.molcel.2020.10.013. Epub 2020 Nov 4. PubMed |
| Human mesenchymal stromal cells do not express ACE2 and TMPRSS2 and are not permissive to SARS-CoV-2 infection. Avanzini MA, Mura M, Percivalle E, Bastaroli F, Croce S, Valsecchi C, Lenta E, Nykjaer G, Cassaniti I, Bagnarino J, Baldanti F, Zecca M, Comoli P, Gnecchi M. Stem Cells Transl Med. 2021 Apr;10(4):636-642. doi: 10.1002/sctm.20-0385. Epub 2021 Jan 26. PubMed |
| A regulatory element in the 3'-untranslated region of CEBPA is associated with myeloid/NK/T-cell leukemia. Kimura Y, Iwanaga E, Iwanaga K, Endo S, Inoue Y, Tokunaga K, Nagahata Y, Masuda K, Kawamoto H, Matsuoka M. Eur J Haematol. 2021 Mar;106(3):327-339. doi: 10.1111/ejh.13551. Epub 2020 Nov 29. PubMed |
| RACK1 Mediates NLRP3 Inflammasome Activation by Promoting NLRP3 Active Conformation and Inflammasome Assembly. Duan Y, Zhang L, Angosto-Bazarra D, Pelegrin P, Nunez G, He Y. Cell Rep. 2020 Nov 17;33(7):108405. doi: 10.1016/j.celrep.2020.108405. PubMed |
| High throughput profiling of undifferentiated pleomorphic sarcomas identifies two main subgroups with distinct immune profile, clinical outcome and sensitivity to targeted therapies. Toulmonde M, Lucchesi C, Verbeke S, Crombe A, Adam J, Geneste D, Chaire V, Laroche-Clary A, Perret R, Bertucci F, Bertolo F, Bianchini L, Dadone-Montaudie B, Hembrough T, Sweet S, Kim YJ, Cecchi F, Le Loarer F, Italiano A. EBioMedicine. 2020 Dec;62:103131. doi: 10.1016/j.ebiom.2020.103131. Epub 2020 Nov 28. PubMed |
| Excessive E2F Transcription in Single Cancer Cells Precludes Transient Cell-Cycle Exit after DNA Damage. Segeren HA, van Rijnberk LM, Moreno E, Riemers FM, van Liere EA, Yuan R, Wubbolts R, de Bruin A, Westendorp B. Cell Rep. 2020 Dec 1;33(9):108449. doi: 10.1016/j.celrep.2020.108449. PubMed |
| Activation of Wnt/beta-catenin signalling and HIF1alpha stabilisation alters pluripotency and differentiation/proliferation properties of human-induced pluripotent stem cells. Wei H, Beeson GC, Ye Z, Zhang J, Yao H, Damon B, Morad M. Biol Cell. 2021 Mar;113(3):133-145. doi: 10.1111/boc.202000055. Epub 2020 Dec 16. PubMed |
| Gene Regulatory Network Analysis and Engineering Directs Development and Vascularization of Multilineage Human Liver Organoids. Velazquez JJ, LeGraw R, Moghadam F, Tan Y, Kilbourne J, Maggiore JC, Hislop J, Liu S, Cats D, Chuva de Sousa Lopes SM, Plaisier C, Cahan P, Kiani S, Ebrahimkhani MR. Cell Syst. 2021 Jan 20;12(1):41-55.e11. doi: 10.1016/j.cels.2020.11.002. Epub 2020 Dec 7. PubMed |
| Heterogeneous bone-marrow stromal progenitors drive myelofibrosis via a druggable alarmin axis. Leimkuhler NB, Gleitz HFE, Ronghui L, Snoeren IAM, Fuchs SNR, Nagai JS, Banjanin B, Lam KH, Vogl T, Kuppe C, Stalmann USA, Busche G, Kreipe H, Gutgemann I, Krebs P, Banz Y, Boor P, Tai EW, Brummendorf TH, Koschmieder S, Crysandt M, Bindels E, Kramann R, Costa IG, Schneider RK. Cell Stem Cell. 2021 Apr 1;28(4):637-652.e8. doi: 10.1016/j.stem.2020.11.004. Epub 2020 Dec 9. PubMed |
| Sorting nexin 5 mediates virus-induced autophagy and immunity. Dong X, Yang Y, Zou Z, Zhao Y, Ci B, Zhong L, Bhave M, Wang L, Kuo YC, Zang X, Zhong R, Aguilera ER, Richardson RB, Simonetti B, Schoggins JW, Pfeiffer JK, Yu L, Zhang X, Xie Y, Schmid SL, Xiao G, Gleeson PA, Ktistakis NT, Cullen PJ, Xavier RJ, Levine B. Nature. 2021 Jan;589(7842):456-461. doi: 10.1038/s41586-020-03056-z. Epub 2020 Dec 16. PubMed |
| Neuronal hyperexcitability is a DLK-dependent trigger of herpes simplex virus reactivation that can be induced by IL-1. Cuddy SR, Schinlever AR, Dochnal S, Seegren PV, Suzich J, Kundu P, Downs TK, Farah M, Desai BN, Boutell C, Cliffe AR. Elife. 2020 Dec 22;9:e58037. doi: 10.7554/eLife.58037. PubMed |
| FGF21 Induced by the ASK1-p38 Pathway Promotes Mechanical Cell Competition by Attracting Cells. Ogawa M, Kawarazaki Y, Fujita Y, Naguro I, Ichijo H. Curr Biol. 2021 Mar 8;31(5):1048-1057.e5. doi: 10.1016/j.cub.2020.11.052. Epub 2020 Dec 22. PubMed |
| Non-canonical Glutamate-Cysteine Ligase Activity Protects against Ferroptosis. Kang YP, Mockabee-Macias A, Jiang C, Falzone A, Prieto-Farigua N, Stone E, Harris IS, DeNicola GM. Cell Metab. 2021 Jan 5;33(1):174-189.e7. doi: 10.1016/j.cmet.2020.12.007. Epub 2020 Dec 22. PubMed |
| Quantitative Imaging of MS2-Tagged hTR in Cajal Bodies: Photobleaching and Photoactivation. Smith M, Querido E, Chartrand P, Sfeir A. STAR Protoc. 2020 Sep 24;1(3):100112. doi: 10.1016/j.xpro.2020.100112. eCollection 2020 Dec 18. PubMed |
| Protocol to Reprogram Human Menstrual Blood-Derived Stromal Cells to Generate AOX15-iPSCs. Sanzhez-Mata A, Ferez-Gomez A, Gonzalez-Munoz E. STAR Protoc. 2020 Nov 25;1(3):100183. doi: 10.1016/j.xpro.2020.100183. eCollection 2020 Dec 18. PubMed |
| Identification of PIM1 substrates reveals a role for NDRG1 phosphorylation in prostate cancer cellular migration and invasion. Ledet RJ, Ruff SE, Wang Y, Nayak S, Schneider JA, Ueberheide B, Logan SK, Garabedian MJ. Commun Biol. 2021 Jan 4;4(1):36. doi: 10.1038/s42003-020-01528-6. PubMed |
| Targeting sphingosine kinase 1 (SK1) enhances oncogene-induced senescence through ceramide synthase 2 (CerS2)-mediated generation of very-long-chain ceramides. Trayssac M, Clarke CJ, Stith JL, Snider JM, Newen N, Gault CR, Hannun YA, Obeid LM. Cell Death Dis. 2021 Jan 4;12(1):27. doi: 10.1038/s41419-020-03281-4. PubMed |
| Functional Hierarchy and Cooperation of EMT Master Transcription Factors in Breast Cancer Metastasis. Addison JB, Voronkova MA, Fugett JH, Lin CC, Linville NC, Trinh B, Livengood RH, Smolkin MB, Schaller MD, Ruppert JM, Pugacheva EN, Creighton CJ, Ivanov AV. Mol Cancer Res. 2021 May;19(5):784-798. doi: 10.1158/1541-7786.MCR-20-0532. Epub 2021 Jan 26. PubMed |
| FOS licenses early events in stem cell activation driving skeletal muscle regeneration. Almada AE, Horwitz N, Price FD, Gonzalez AE, Ko M, Bolukbasi OV, Messemer KA, Chen S, Sinha M, Rubin LL, Wagers AJ. Cell Rep. 2021 Jan 26;34(4):108656. doi: 10.1016/j.celrep.2020.108656. PubMed |
| Metoclopramide treatment blocks CD93-signaling-mediated self-renewal of chronic myeloid leukemia stem cells. Riether C, Radpour R, Kallen NM, Burgin DT, Bachmann C, Schurch CM, Luthi U, Arambasic M, Hoppe S, Albers CE, Baerlocher GM, Ochsenbein AF. Cell Rep. 2021 Jan 26;34(4):108663. doi: 10.1016/j.celrep.2020.108663. PubMed |
| Galphao is a major determinant of cAMP signaling in the pathophysiology of movement disorders. Muntean BS, Masuho I, Dao M, Sutton LP, Zucca S, Iwamoto H, Patil DN, Wang D, Birnbaumer L, Blakely RD, Grill B, Martemyanov KA. Cell Rep. 2021 Feb 2;34(5):108718. doi: 10.1016/j.celrep.2021.108718. PubMed |
| PRMT6 methylation of RCC1 regulates mitosis, tumorigenicity, and radiation response of glioblastoma stem cells. Huang T, Yang Y, Song X, Wan X, Wu B, Sastry N, Horbinski CM, Zeng C, Tiek D, Goenka A, Liu F, Brennan CW, Kessler JA, Stupp R, Nakano I, Sulman EP, Nishikawa R, James CD, Zhang W, Xu W, Hu B, Cheng SY. Mol Cell. 2021 Mar 18;81(6):1276-1291.e9. doi: 10.1016/j.molcel.2021.01.015. Epub 2021 Feb 3. PubMed |
| Acute Kidney Injury Instigates Malignant Renal Cell Carcinoma via CXCR2 in Mice with Inactivated Trp53 and Pten in Proximal Tubular Kidney Epithelial Cells. Zhou X, Xiao F, Sugimoto H, Li B, McAndrews KM, Kalluri R. Cancer Res. 2021 May 15;81(10):2690-2702. doi: 10.1158/0008-5472.CAN-20-2930. Epub 2021 Feb 8. PubMed |
| Identification of a long non-coding RNA regulator of liver carcinoma cell survival. Rybakova Y, Gonzalez JT, Bogorad R, Chauhan VP, Dong YL, Whittaker CA, Zatsepin T, Koteliansky V, Anderson DG. Cell Death Dis. 2021 Feb 15;12(2):178. doi: 10.1038/s41419-021-03453-w. PubMed |
| Inhibitory CD161 receptor identified in glioma-infiltrating T cells by single-cell analysis. Mathewson ND, Ashenberg O, Tirosh I, Gritsch S, Perez EM, Marx S, Jerby-Arnon L, Chanoch-Myers R, Hara T, Richman AR, Ito Y, Pyrdol J, Friedrich M, Schumann K, Poitras MJ, Gokhale PC, Gonzalez Castro LN, Shore ME, Hebert CM, Shaw B, Cahill HL, Drummond M, Zhang W, Olawoyin O, Wakimoto H, Rozenblatt-Rosen O, Brastianos PK, Liu XS, Jones PS, Cahill DP, Frosch MP, Louis DN, Freeman GJ, Ligon KL, Marson A, Chiocca EA, Reardon DA, Regev A, Suva ML, Wucherpfennig KW. Cell. 2021 Mar 4;184(5):1281-1298.e26. doi: 10.1016/j.cell.2021.01.022. Epub 2021 Feb 15. PubMed |
| TAMEP are brain tumor parenchymal cells controlling neoplastic angiogenesis and progression. Kalin RE, Cai L, Li Y, Zhao D, Zhang H, Cheng J, Zhang W, Wu Y, Eisenhut K, Janssen P, Schmitt L, Enard W, Michels F, Fluh C, Hou M, Kirchleitner SV, Siller S, Schiemann M, Andra I, Montanez E, Giachino C, Taylor V, Synowitz M, Tonn JC, von Baumgarten L, Schulz C, Hellmann I, Glass R. Cell Syst. 2021 Mar 17;12(3):248-262.e7. doi: 10.1016/j.cels.2021.01.002. Epub 2021 Feb 15. PubMed |
A functional taxonomy of tumor suppression in oncogenic KRAS-driven lung cancer.
Cai H, Chew SK, Li C, Tsai MK, Andrejka L, Murray CW, Hughes NW, Shuldiner EG, Ashkin EL, Tang R, Hung KL, Chen LC, Lee SYC, Yousefi M, Lin WY, Kunder CA, Cong L, McFarland CD, Petrov DA, Swanton C, Winslow MM.
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| Genome-wide CRISPR/Cas9-knockout in human induced Pluripotent Stem Cell (iPSC)-derived macrophages. Navarro-Guerrero E, Tay C, Whalley JP, Cowley SA, Davies B, Knight JC, Ebner D. Sci Rep. 2021 Feb 19;11(1):4245. doi: 10.1038/s41598-021-82137-z. PubMed |
| Targeting EphA2 suppresses hepatocellular carcinoma initiation and progression by dual inhibition of JAK1/STAT3 and AKT signaling. Wang H, Hou W, Perera A, Bettler C, Beach JR, Ding X, Li J, Denning MF, Dhanarajan A, Cotler SJ, Joyce C, Yin J, Ahmed F, Roberts LR, Qiu W. Cell Rep. 2021 Feb 23;34(8):108765. doi: 10.1016/j.celrep.2021.108765. PubMed |
| SARM1 is a metabolic sensor activated by an increased NMN/NAD(+) ratio to trigger axon degeneration. Figley MD, Gu W, Nanson JD, Shi Y, Sasaki Y, Cunnea K, Malde AK, Jia X, Luo Z, Saikot FK, Mosaiab T, Masic V, Holt S, Hartley-Tassell L, McGuinness HY, Manik MK, Bosanac T, Landsberg MJ, Kerry PS, Mobli M, Hughes RO, Milbrandt J, Kobe B, DiAntonio A, Ve T. Neuron. 2021 Apr 7;109(7):1118-1136.e11. doi: 10.1016/j.neuron.2021.02.009. Epub 2021 Mar 2. PubMed |
| Osteopontin Blockade Immunotherapy Increases Cytotoxic T Lymphocyte Lytic Activity and Suppresses Colon Tumor Progression. Klement JD, Poschel DB, Lu C, Merting AD, Yang D, Redd PS, Liu K. Cancers (Basel). 2021 Feb 28;13(5). pii: cancers13051006. doi: 10.3390/cancers13051006. PubMed |
| RAF-Mutant Melanomas Differentially Depend on ERK2 Over ERK1 to Support Aberrant MAPK Pathway Activation and Cell Proliferation. Crowe MS, Zavorotinskaya T, Voliva CF, Shirley MD, Wang Y, Ruddy DA, Rakiec DP, Engelman JA, Stuart DD, Freeman AK. Mol Cancer Res. 2021 Jun;19(6):1063-1075. doi: 10.1158/1541-7786.MCR-20-1022. Epub 2021 Mar 11. PubMed |
| O-GlcNAcylation homeostasis controlled by calcium influx channels regulates multiple myeloma dissemination. Samart P, Luanpitpong S, Rojanasakul Y, Issaragrisil S. J Exp Clin Cancer Res. 2021 Mar 16;40(1):100. doi: 10.1186/s13046-021-01876-z. PubMed |
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| Construction of differential expression plasmids of NGF to detect its influence on PC12 cell neuronal differentiation. Liu Y, Zou L, Wang P, Zhou J, Yuan C, Wang J. Exp Ther Med. 2021 Apr;21(4):363. doi: 10.3892/etm.2021.9794. Epub 2021 Feb 14. PubMed |
| Overlapping roles of JIP3 and JIP4 in promoting axonal transport of lysosomes in human iPSC-derived neurons. Gowrishankar S, Lyons L, Rafiq NM, Roczniak-Ferguson A, De Camilli P, Ferguson SM. Mol Biol Cell. 2021 May 15;32(11):1094-1103. doi: 10.1091/mbc.E20-06-0382. Epub 2021 Mar 31. PubMed |
| Seed-mediated RNA interference of androgen signaling and survival networks induces cell death in prostate cancer cells. Corbin JM, Georgescu C, Wren JD, Xu C, Asch AS, Ruiz-Echevarria MJ. Mol Ther Nucleic Acids. 2021 Mar 5;24:337-351. doi: 10.1016/j.omtn.2021.03.002. eCollection 2021 Jun 4. PubMed |
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Psychedelic-inspired drug discovery using an engineered biosensor.
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Cell. 2021 Apr 8. pii: S0092-8674(21)00374-3. doi: 10.1016/j.cell.2021.03.043.
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| Laser Micro-Irradiation to Study DNA Recruitment During S Phase. Miwatani-Minter B, Rona G. J Vis Exp. 2021 Apr 16;(170). doi: 10.3791/62466. PubMed |
| G3BP1 Inhibition Alleviates Intracellular Nucleic Acid-Induced Autoimmune Responses. Cai H, Liu X, Zhang F, Han QY, Liu ZS, Xue W, Guo ZL, Zhao JM, Sun LM, Wang N, Mao J, He K, Xia T, Chen Y, Chen L, Li AL, Zhou T, Zhang XM, Li WH, Li T. J Immunol. 2021 May 15;206(10):2453-2467. doi: 10.4049/jimmunol.2001111. Epub 2021 May 3. PubMed |
| The oncogenic E3 ligase TRIP12 suppresses epithelial-mesenchymal transition (EMT) and mesenchymal traits through ZEB1/2. Lee KK, Rajagopalan D, Bhatia SS, Tirado-Magallanes R, Chng WJ, Jha S. Cell Death Discov. 2021 May 7;7(1):95. doi: 10.1038/s41420-021-00479-z. PubMed |
Longitudinal proteomic analysis of severe COVID-19 reveals survival-associated signatures, tissue-specific cell death, and cell-cell interactions.
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| Navigating CAR-T cells through the solid-tumour microenvironment. Hou AJ, Chen LC, Chen YY. Nat Rev Drug Discov. 2021 Jul;20(7):531-550. doi: 10.1038/s41573-021-00189-2. Epub 2021 May 10. PubMed |
| Rab34 GTPase mediates ciliary membrane formation in the intracellular ciliogenesis pathway. Ganga AK, Kennedy MC, Oguchi ME, Gray S, Oliver KE, Knight TA, De La Cruz EM, Homma Y, Fukuda M, Breslow DK. Curr Biol. 2021 Jul 12;31(13):2895-2905.e7. doi: 10.1016/j.cub.2021.04.075. Epub 2021 May 13. PubMed |
| ILF3 Is a Negative Transcriptional Regulator of Innate Immune Responses and Myeloid Dendritic Cell Maturation. Nazitto R, Amon LM, Mast FD, Aitchison JD, Aderem A, Johnson JS, Diercks AH. J Immunol. 2021 May 24. pii: jimmunol.2001235. doi: 10.4049/jimmunol.2001235. PubMed |
| The autophagy protein Becn1 improves insulin sensitivity by promoting adiponectin secretion via exocyst binding. Kuramoto K, Kim YJ, Hong JH, He C. Cell Rep. 2021 May 25;35(8):109184. doi: 10.1016/j.celrep.2021.109184. PubMed |
| Role of IQGAP1 in Papillomavirus-Associated Head and Neck Tumorigenesis. Wei T, Choi S, Buehler D, Lee D, Ward-Shaw E, Anderson RA, Lambert PF. Cancers (Basel). 2021 May 10;13(9). pii: cancers13092276. doi: 10.3390/cancers13092276. PubMed |
Targeted delivery of CRISPR-Cas9 and transgenes enables complex immune cell engineering.
Hamilton JR, Tsuchida CA, Nguyen DN, Shy BR, McGarrigle ER, Sandoval Espinoza CR, Carr D, Blaeschke F, Marson A, Doudna JA.
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| miR-590-5p targets RMND5A and promotes migration in pancreatic adenocarcinoma cell lines. Chen S, Chen Y, Wen Y, Cai W, Zhu P, Yuan W, Li Y, Fan X, Wan Y, Li F, Zhuang J, Jiang Z, Wu X, Wang Y. Oncol Lett. 2021 Jul;22(1):532. doi: 10.3892/ol.2021.12793. Epub 2021 May 17. PubMed |
| Functionality of a bicistronic construction containing HEXA and HEXB genes encoding beta-hexosaminidase A for cell-mediated therapy of GM2 gangliosidoses. Shaimardanova AA, Chulpanova DS, Solovyeva VV, Aimaletdinov AM, Rizvanov AA. Neural Regen Res. 2022 Jan;17(1):122-129. doi: 10.4103/1673-5374.314310. PubMed |
| Efficient Derivation of Excitatory and Inhibitory Neurons from Human Pluripotent Stem Cells Stably Expressing Direct Reprogramming Factors. Song S, Ashok A, Williams D, Kaufman M, Duff K, Sproul A. Curr Protoc. 2021 Jun;1(6):e141. doi: 10.1002/cpz1.141. PubMed |
| HGK promotes metastatic dissemination in prostate cancer. Garcia-Garcia S, Rodrigo-Faus M, Fonseca N, Manzano S, Gyorffy B, Ocana A, Bragado P, Porras A, Gutierrez-Uzquiza A. Sci Rep. 2021 Jun 10;11(1):12287. doi: 10.1038/s41598-021-91292-2. PubMed |
| STAG2 loss rewires oncogenic and developmental programs to promote metastasis in Ewing sarcoma. Adane B, Alexe G, Seong BKA, Lu D, Hwang EE, Hnisz D, Lareau CA, Ross L, Lin S, Dela Cruz FS, Richardson M, Weintraub AS, Wang S, Iniguez AB, Dharia NV, Conway AS, Robichaud AL, Tanenbaum B, Krill-Burger JM, Vazquez F, Schenone M, Berman JN, Kung AL, Carr SA, Aryee MJ, Young RA, Crompton BD, Stegmaier K. Cancer Cell. 2021 Jun 14;39(6):827-844.e10. doi: 10.1016/j.ccell.2021.05.007. PubMed |
| Using the dCas9-KRAB system to repress gene expression in hiPSC-derived NGN2 neurons. Li A, Cartwright S, Yu A, Ho SM, Schrode N, Deans PJM, Matos MR, Garcia MF, Townsley KG, Zhang B, Brennand KJ. STAR Protoc. 2021 Jun 3;2(2):100580. doi: 10.1016/j.xpro.2021.100580. eCollection 2021 Jun 18. PubMed |
| Expression regulation and function of PD-1 and PD-L1 in T lymphoma cells. Liu MY, Klement JD, Langan CJ, van Riggelen J, Liu K. Cell Immunol. 2021 Aug;366:104397. doi: 10.1016/j.cellimm.2021.104397. Epub 2021 Jun 17. PubMed |
| Glycogen Synthase Kinase 3 Beta Regulates the Human Aryl Hydrocarbon Receptor Cellular Content and Activity. Yang Y, Chan WK. Int J Mol Sci. 2021 Jun 5;22(11). pii: ijms22116097. doi: 10.3390/ijms22116097. PubMed |
| Methods for Modulating the Pathway of NF-kappaB Using Short Hairpin RNA (ShRNA). Moretti M, Di Francesco B, Nolfi MDV, Angrisani A, De Smaele E. Methods Mol Biol. 2021;2366:95-107. doi: 10.1007/978-1-0716-1669-7_6. PubMed |
| Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway. Evavold CL, Hafner-Bratkovic I, Devant P, D'Andrea JM, Ngwa EM, Borsic E, Doench JG, LaFleur MW, Sharpe AH, Thiagarajah JR, Kagan JC. Cell. 2021 Aug 19;184(17):4495-4511.e19. doi: 10.1016/j.cell.2021.06.028. Epub 2021 Jul 21. PubMed |
| Ribosome ADP-ribosylation inhibits translation and maintains proteostasis in cancers. Challa S, Khulpateea BR, Nandu T, Camacho CV, Ryu KW, Chen H, Peng Y, Lea JS, Kraus WL. Cell. 2021 Aug 19;184(17):4531-4546.e26. doi: 10.1016/j.cell.2021.07.005. Epub 2021 Jul 26. PubMed |
| RalA and PLD1 promote lipid droplet growth in response to nutrient withdrawal. Hussain SS, Tran TM, Ware TB, Luse MA, Prevost CT, Ferguson AN, Kashatus JA, Hsu KL, Kashatus DF. Cell Rep. 2021 Jul 27;36(4):109451. doi: 10.1016/j.celrep.2021.109451. PubMed |
| Direct characterization of cis-regulatory elements and functional dissection of complex genetic associations using HCR-FlowFISH. Reilly SK, Gosai SJ, Gutierrez A, Mackay-Smith A, Ulirsch JC, Kanai M, Mouri K, Berenzy D, Kales S, Butler GM, Gladden-Young A, Bhuiyan RM, Stitzel ML, Finucane HK, Sabeti PC, Tewhey R. Nat Genet. 2021 Aug;53(8):1166-1176. doi: 10.1038/s41588-021-00900-4. Epub 2021 Jul 29. PubMed |
| A subthreshold synaptic mechanism regulating BDNF expression and resting synaptic strength. Horvath PM, Chanaday NL, Alten B, Kavalali ET, Monteggia LM. Cell Rep. 2021 Aug 3;36(5):109467. doi: 10.1016/j.celrep.2021.109467. PubMed |
| The biochemical basis of mitochondrial dysfunction in Zellweger Spectrum Disorder. Nuebel E, Morgan JT, Fogarty S, Winter JM, Lettlova S, Berg JA, Chen YC, Kidwell CU, Maschek JA, Clowers KJ, Argyriou C, Chen L, Wittig I, Cox JE, Roh-Johnson M, Braverman N, Bonkowsky J, Gygi SP, Rutter J. EMBO Rep. 2021 Oct 5;22(10):e51991. doi: 10.15252/embr.202051991. Epub 2021 Aug 5. PubMed |
| The structural dynamics of macropinosome formation and PI3-kinase-mediated sealing revealed by lattice light sheet microscopy. Quinn SE, Huang L, Kerkvliet JG, Swanson JA, Smith S, Hoppe AD, Anderson RB, Thiex NW, Scott BL. Nat Commun. 2021 Aug 10;12(1):4838. doi: 10.1038/s41467-021-25187-1. PubMed |
| Actinin BioID reveals sarcomere crosstalk with oxidative metabolism through interactions with IGF2BP2. Ladha FA, Thakar K, Pettinato AM, Legere N, Ghahremani S, Cohn R, Romano R, Meredith E, Chen YS, Hinson JT. Cell Rep. 2021 Aug 10;36(6):109512. doi: 10.1016/j.celrep.2021.109512. PubMed |
| DDX52 knockdown inhibits the growth of prostate cancer cells by regulating c-Myc signaling. Yu W, Ma H, Li J, Ge J, Wang P, Zhou Y, Zhang J, Shi G. Cancer Cell Int. 2021 Aug 16;21(1):430. doi: 10.1186/s12935-021-02128-y. PubMed |
| Capturing membrane trafficking events during 3D angiogenic development in vitro. Francis CR, Kushner EJ. Microcirculation. 2022 Oct;29(6-7):e12726. doi: 10.1111/micc.12726. Epub 2021 Aug 29. PubMed |
Visualizing looping of two endogenous genomic loci using synthetic zinc-finger proteins with anti-FLAG and anti-HA frankenbodies in living cells.
Liu Y, Zhao N, Kanemaki MT, Yamamoto Y, Sadamura Y, Ito Y, Tokunaga M, Stasevich TJ, Kimura H.
Genes Cells. 2021 Nov;26(11):905-926. doi: 10.1111/gtc.12893. Epub 2021 Sep 20.
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Discovery of synthetic lethal and tumor suppressor paralog pairs in the human genome.
Parrish PCR, Thomas JD, Gabel AM, Kamlapurkar S, Bradley RK, Berger AH.
Cell Rep. 2021 Aug 31;36(9):109597. doi: 10.1016/j.celrep.2021.109597.
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| Protocol for CRISPR-Cas9 modification of glycosylation in 3D organotypic skin models. Marinova IN, Wandall HH, Dabelsteen S. STAR Protoc. 2021 Jul 10;2(3):100668. doi: 10.1016/j.xpro.2021.100668. eCollection 2021 Sep 17. PubMed |
| Mitofusin-2 regulates leukocyte adhesion and beta2 integrin activation. Liu W, Hsu AY, Wang Y, Lin T, Sun H, Pachter JS, Groisman A, Imperioli M, Yungher FW, Hu L, Wang P, Deng Q, Fan Z. J Leukoc Biol. 2022 Apr;111(4):771-791. doi: 10.1002/JLB.1A0720-471R. Epub 2021 Sep 8. PubMed |
| NSD2 dimethylation at H3K36 promotes lung adenocarcinoma pathogenesis. Sengupta D, Zeng L, Li Y, Hausmann S, Ghosh D, Yuan G, Nguyen TN, Lyu R, Caporicci M, Morales Benitez A, Coles GL, Kharchenko V, Czaban I, Azhibek D, Fischle W, Jaremko M, Wistuba II, Sage J, Jaremko L, Li W, Mazur PK, Gozani O. Mol Cell. 2021 Nov 4;81(21):4481-4492.e9. doi: 10.1016/j.molcel.2021.08.034. Epub 2021 Sep 22. PubMed |
| Lrp1 is a host entry factor for Rift Valley fever virus. Ganaie SS, Schwarz MM, McMillen CM, Price DA, Feng AX, Albe JR, Wang W, Miersch S, Orvedahl A, Cole AR, Sentmanat MF, Mishra N, Boyles DA, Koenig ZT, Kujawa MR, Demers MA, Hoehl RM, Moyle AB, Wagner ND, Stubbs SH, Cardarelli L, Teyra J, McElroy A, Gross ML, Whelan SPJ, Doench J, Cui X, Brett TJ, Sidhu SS, Virgin HW, Egawa T, Leung DW, Amarasinghe GK, Hartman AL. Cell. 2021 Sep 30;184(20):5163-5178.e24. doi: 10.1016/j.cell.2021.09.001. Epub 2021 Sep 23. PubMed |
| A guide in lentiviral vector production for hard-to-transfect cells, using cardiac-derived c-kit expressing cells as a model system. Kalidasan V, Ng WH, Ishola OA, Ravichantar N, Tan JJ, Das KT. Sci Rep. 2021 Sep 28;11(1):19265. doi: 10.1038/s41598-021-98657-7. PubMed |
| ZFP423 controls EBF2 coactivator recruitment and PPARgamma occupancy to determine the thermogenic plasticity of adipocytes. Shao M, Zhang Q, Truong A, Shan B, Vishvanath L, Li L, Seale P, Gupta RK. Genes Dev. 2021 Nov 1;35(21-22):1461-1474. doi: 10.1101/gad.348780.121. Epub 2021 Oct 7. PubMed |
| DYNC1LI2 regulates localization of the chaperone-mediated autophagy receptor LAMP2A and improves cellular homeostasis in cystinosis. Rahman F, Johnson JL, Zhang J, He J, Pestonjamasp K, Cherqui S, Catz SD. Autophagy. 2021 Oct 13:1-19. doi: 10.1080/15548627.2021.1971937. PubMed |
| YAP inhibition promotes endothelial cell differentiation from pluripotent stem cell through EC master transcription factor FLI1. Quan Y, Shan X, Hu M, Jin P, Ma J, Fan J, Yang J, Zhang H, Fan X, Gong Y, Li M, Wang Y. J Mol Cell Cardiol. 2022 Feb;163:81-96. doi: 10.1016/j.yjmcc.2021.10.004. Epub 2021 Oct 16. PubMed |
| Irisin Stimulates the Release of CXCL1 From Differentiating Human Subcutaneous and Deep-Neck Derived Adipocytes via Upregulation of NFkappaB Pathway. Shaw A, Toth BB, Kiraly R, Arianti R, Csomos I, Poliska S, Vamos A, Korponay-Szabo IR, Bacso Z, Gyory F, Fesus L, Kristof E. Front Cell Dev Biol. 2021 Oct 11;9:737872. doi: 10.3389/fcell.2021.737872. eCollection 2021. PubMed |
| Mitochondrial respiration contributes to the interferon gamma response in antigen-presenting cells. Kiritsy MC, McCann K, Mott D, Holland SM, Behar SM, Sassetti CM, Olive AJ. Elife. 2021 Nov 2;10. pii: 65109. doi: 10.7554/eLife.65109. PubMed |
| Convergence of distinct signaling pathways on synaptic scaling to trigger rapid antidepressant action. Suzuki K, Kim JW, Nosyreva E, Kavalali ET, Monteggia LM. Cell Rep. 2021 Nov 2;37(5):109918. doi: 10.1016/j.celrep.2021.109918. PubMed |
| Optimized protocol to create deletion in adherent cell lines using CRISPR/Cas9 system. Farooq U, Notani D. STAR Protoc. 2021 Oct 22;2(4):100857. doi: 10.1016/j.xpro.2021.100857. eCollection 2021 Dec 17. PubMed |
| TIAM1-RAC1 promote small-cell lung cancer cell survival through antagonizing Nur77-induced BCL2 conformational change. Payapilly A, Guilbert R, Descamps T, White G, Magee P, Zhou C, Kerr A, Simpson KL, Blackhall F, Dive C, Malliri A. Cell Rep. 2021 Nov 9;37(6):109979. doi: 10.1016/j.celrep.2021.109979. PubMed |
| MTHFD2 is a metabolic checkpoint controlling effector and regulatory T cell fate and function. Sugiura A, Andrejeva G, Voss K, Heintzman DR, Xu X, Madden MZ, Ye X, Beier KL, Chowdhury NU, Wolf MM, Young AC, Greenwood DL, Sewell AE, Shahi SK, Freedman SN, Cameron AM, Foerch P, Bourne T, Garcia-Canaveras JC, Karijolich J, Newcomb DC, Mangalam AK, Rabinowitz JD, Rathmell JC. Immunity. 2022 Jan 11;55(1):65-81.e9. doi: 10.1016/j.immuni.2021.10.011. Epub 2021 Nov 11. PubMed |
| Gene editing with CRISPR-Cas12a guides possessing ribose-modified pseudoknot handles. Ageely EA, Chilamkurthy R, Jana S, Abdullahu L, O'Reilly D, Jensik PJ, Damha MJ, Gagnon KT. Nat Commun. 2021 Nov 15;12(1):6591. doi: 10.1038/s41467-021-26989-z. PubMed |
| Ciliary Type III Adenylyl Cyclase in the VMH Is Crucial for High-Fat Diet-Induced Obesity Mediated by Autophagy. Yang D, Wu X, Wang W, Zhou Y, Wang Z. Adv Sci (Weinh). 2022 Jan;9(3):e2102568. doi: 10.1002/advs.202102568. Epub 2021 Nov 16. PubMed |
| Mutations of the histone linker H1-4 in neurodevelopmental disorders and functional characterization of neurons expressing C-terminus frameshift mutant H1.4. Tremblay MW, Green MV, Goldstein BM, Aldridge AI, Rosenfeld JA, Streff H, Tan WD, Craigen W, Bekheirnia N, Al Tala S, West AE, Jiang YH. Hum Mol Genet. 2021 Nov 12. pii: 6414843. doi: 10.1093/hmg/ddab321. PubMed |
| Soluble guanylate cyclase signalling mediates etoposide resistance in progressing small cell lung cancer. Schenk MW, Humphrey S, Hossain ASMM, Revill M, Pearsall S, Lallo A, Brown S, Bratt S, Galvin M, Descamps T, Zhou C, Pearce SP, Priest L, Greenhalgh M, Chaturvedi A, Kerr A, Blackhall F, Dive C, Frese KK. Nat Commun. 2021 Nov 17;12(1):6652. doi: 10.1038/s41467-021-26823-6. PubMed |
| PARP1 PARylates and stabilizes STAT5 in FLT3-ITD acute myeloid leukemia and other STAT5-activated cancers. Dellomo AJ, Abbotts R, Eberly CL, Karbowski M, Baer MR, Kingsbury TJ, Rassool FV. Transl Oncol. 2022 Jan;15(1):101283. doi: 10.1016/j.tranon.2021.101283. Epub 2021 Nov 19. PubMed |
| Statins affect cancer cell plasticity with distinct consequences for tumor progression and metastasis. Dorsch M, Kowalczyk M, Planque M, Heilmann G, Urban S, Dujardin P, Forster J, Ueffing K, Nothdurft S, Oeck S, Paul A, Liffers ST, Kaschani F, Kaiser M, Schramm A, Siveke JT, Winslow MM, Fendt SM, Nalbant P, Gruner BM. Cell Rep. 2021 Nov 23;37(8):110056. doi: 10.1016/j.celrep.2021.110056. PubMed |
| Knockdown of Astrocytic Monocarboxylate Transporter 4 in the Motor Cortex Leads to Loss of Dendritic Spines and a Deficit in Motor Learning. Lundquist AJ, Llewellyn GN, Kishi SH, Jakowec NA, Cannon PM, Petzinger GM, Jakowec MW. Mol Neurobiol. 2022 Feb;59(2):1002-1017. doi: 10.1007/s12035-021-02651-z. Epub 2021 Nov 25. PubMed |
| Extracellular cathepsin Z signals through the alpha5 integrin and augments NLRP3 inflammasome activation. Campden RI, Warren AL, Greene CJ, Chiriboga JA, Arnold CR, Aggarwal D, McKenna N, Sandall CF, MacDonald JA, Yates RM. J Biol Chem. 2022 Jan;298(1):101459. doi: 10.1016/j.jbc.2021.101459. Epub 2021 Dec 2. PubMed |
| EGFR Transgene Stimulates Spontaneous Formation of MCF7 Breast Cancer Cells Spheroids with Partly Loss of HER3 Receptor. Troitskaya O, Novak D, Nushtaeva A, Savinkova M, Varlamov M, Ermakov M, Richter V, Koval O. Int J Mol Sci. 2021 Nov 29;22(23). pii: ijms222312937. doi: 10.3390/ijms222312937. PubMed |
| The short isoform of the host antiviral protein ZAP acts as an inhibitor of SARS-CoV-2 programmed ribosomal frameshifting. Zimmer MM, Kibe A, Rand U, Pekarek L, Ye L, Buck S, Smyth RP, Cicin-Sain L, Caliskan N. Nat Commun. 2021 Dec 10;12(1):7193. doi: 10.1038/s41467-021-27431-0. PubMed |
Rapid genome editing by CRISPR-Cas9-POLD3 fusion.
Reint G, Li Z, Labun K, Keskitalo S, Soppa I, Mamia K, Tolo E, Szymanska M, Meza-Zepeda LA, Lorenz S, Cieslar-Pobuda A, Hu X, Bordin DL, Staerk J, Valen E, Schmierer B, Varjosalo M, Taipale J, Haapaniemi E.
Elife. 2021 Dec 13;10. pii: 75415. doi: 10.7554/eLife.75415.
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| Ablation of T cell-associated PD-1H enhances functionality and promotes adoptive immunotherapy. Hu L, Chen L, Xiao Z, Zheng X, Chen Y, Xian N, Cho C, Luo L, Huang G, Chen L. JCI Insight. 2022 Jan 25;7(2). pii: 148247. doi: 10.1172/jci.insight.148247. PubMed |
| Defective brown adipose tissue thermogenesis and impaired glucose metabolism in mice lacking Letmd1. Choi KM, Kim JH, Kong X, Isik M, Zhang J, Lim HW, Yoon JC. Cell Rep. 2021 Dec 14;37(11):110104. doi: 10.1016/j.celrep.2021.110104. PubMed |
| WASp triggers mechanosensitive actin patches to facilitate immune cell migration in dense tissues. Gaertner F, Reis-Rodrigues P, de Vries I, Hons M, Aguilera J, Riedl M, Leithner A, Tasciyan S, Kopf A, Merrin J, Zheden V, Kaufmann WA, Hauschild R, Sixt M. Dev Cell. 2022 Jan 10;57(1):47-62.e9. doi: 10.1016/j.devcel.2021.11.024. Epub 2021 Dec 16. PubMed |
| Multifunctional barcoding with ClonMapper enables high-resolution study of clonal dynamics during tumor evolution and treatment. Gutierrez C, Al'Khafaji AM, Brenner E, Johnson KE, Gohil SH, Lin Z, Knisbacher BA, Durrett RE, Li S, Parvin S, Biran A, Zhang W, Rassenti L, Kipps TJ, Livak KJ, Neuberg D, Letai A, Getz G, Wu CJ, Brock A. Nat Cancer. 2021 Jul;2(7):758-772. doi: 10.1038/s43018-021-00222-8. Epub 2021 Jul 12. PubMed |
| A beta-Catenin-TCF-Sensitive Locus Control Region Mediates GUCY2C Ligand Loss in Colorectal Cancer. Rappaport JA, Entezari AA, Caspi A, Caksa S, Jhaveri AV, Stanek TJ, Ertel A, Kupper J, Fortina PM, McMahon SB, Jaynes JB, Snook AE, Waldman SA. Cell Mol Gastroenterol Hepatol. 2022;13(4):1276-1296. doi: 10.1016/j.jcmgh.2021.12.014. Epub 2021 Dec 22. PubMed |
| Epigenetic regulation of ferroptosis via ETS1/miR-23a-3p/ACSL4 axis mediates sorafenib resistance in human hepatocellular carcinoma. Lu Y, Chan YT, Tan HY, Zhang C, Guo W, Xu Y, Sharma R, Chen ZS, Zheng YC, Wang N, Feng Y. J Exp Clin Cancer Res. 2022 Jan 3;41(1):3. doi: 10.1186/s13046-021-02208-x. PubMed |
| SUMOylation inhibition enhances dexamethasone sensitivity in multiple myeloma. Du L, Liu W, Aldana-Masangkay G, Pozhitkov A, Pichiorri F, Chen Y, Rosen ST. J Exp Clin Cancer Res. 2022 Jan 4;41(1):8. doi: 10.1186/s13046-021-02226-9. PubMed |
| Restriction of extracellular lipids renders pancreatic cancer dependent on autophagy. Saliakoura M, Sebastiano MR, Nikdima I, Pozzato C, Konstantinidou G. J Exp Clin Cancer Res. 2022 Jan 8;41(1):16. doi: 10.1186/s13046-021-02231-y. PubMed |
| Targeting the Fusion Process of SARS-CoV-2 Infection by Small Molecule Inhibitors. Park SB, Irvin P, Hu Z, Khan M, Hu X, Zeng Q, Chen C, Xu M, Leek M, Zang R, Case JB, Zheng W, Ding S, Liang TJ. mBio. 2022 Feb 22;13(1):e0323821. doi: 10.1128/mbio.03238-21. Epub 2022 Jan 11. PubMed |
| PHY34 inhibits autophagy through V-ATPase V0A2 subunit inhibition and CAS/CSE1L nuclear cargo trafficking in high grade serous ovarian cancer. Salvi A, Young AN, Huntsman AC, Pergande MR, Korkmaz MA, Rathnayake RA, Mize BK, Kinghorn AD, Zhang X, Ratia K, Schirle M, Thomas JR, Brittain SM, Shelton C, Aldrich LN, Cologna SM, Fuchs JR, Burdette JE. Cell Death Dis. 2022 Jan 10;13(1):45. doi: 10.1038/s41419-021-04495-w. PubMed |
Engineered virus-like particles for efficient in vivo delivery of therapeutic proteins.
Banskota S, Raguram A, Suh S, Du SW, Davis JR, Choi EH, Wang X, Nielsen SC, Newby GA, Randolph PB, Osborn MJ, Musunuru K, Palczewski K, Liu DR.
Cell. 2022 Jan 7. pii: S0092-8674(21)01484-7. doi: 10.1016/j.cell.2021.12.021.
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| Lysoptosis is an evolutionarily conserved cell death pathway moderated by intracellular serpins. Luke CJ, Markovina S, Good M, Wight IE, Thomas BJ, Linneman JM, Lanik WE, Koroleva O, Coffman MR, Miedel MT, Gong Q, Andress A, Campos Guerrero M, Wang S, Chen L, Beatty WL, Hausmann KN, White FV, Fitzpatrick JAJ, Orvedahl A, Pak SC, Silverman GA. Commun Biol. 2022 Jan 12;5(1):47. doi: 10.1038/s42003-021-02953-x. PubMed |
| Discovery of small-molecule positive allosteric modulators of Parkin E3 ligase. Shlevkov E, Murugan P, Montagna D, Stefan E, Hadzipasic A, Harvey JS, Kumar PR, Entova S, Bansal N, Bickford S, Wong LY, Hirst WD, Weihofen A, Silvian LF. iScience. 2021 Dec 18;25(1):103650. doi: 10.1016/j.isci.2021.103650. eCollection 2022 Jan 21. PubMed |
| The Immune-Specific E3 Ubiquitin Ligase MARCH1 Is Upregulated during Human Cytomegalovirus Infection to Regulate Iron Levels. Martin M, Sandhu P, Kumar R, Buchkovich NJ. J Virol. 2022 Mar 23;96(6):e0180621. doi: 10.1128/jvi.01806-21. Epub 2022 Jan 19. PubMed |
Presynaptic mechanisms underlying GABA(B)-receptor-mediated inhibition of spontaneous neurotransmitter release.
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Cell Rep. 2022 Jan 18;38(3):110255. doi: 10.1016/j.celrep.2021.110255.
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Engineering T-Cell Resistance to HIV-1 Infection via Knock-In of Peptides from the Heptad Repeat 2 Domain of gp41.
Maslennikova A, Kruglova N, Kalinichenko S, Komkov D, Shepelev M, Golubev D, Siniavin A, Vzorov A, Filatov A, Mazurov D.
mBio. 2022 Jan 25:e0358921. doi: 10.1128/mbio.03589-21.
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| ER stress-induced cell death proceeds independently of the TRAIL-R2 signaling axis in pancreatic beta cells. Hagenlocher C, Siebert R, Taschke B, Wieske S, Hausser A, Rehm M. Cell Death Discov. 2022 Jan 24;8(1):34. doi: 10.1038/s41420-022-00830-y. PubMed |
| Disruption of actin dynamics induces autophagy of the eukaryotic chaperonin TRiC/CCT. Date Y, Matsuura A, Itakura E. Cell Death Discov. 2022 Jan 25;8(1):37. doi: 10.1038/s41420-022-00828-6. PubMed |
| SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses. Dejnirattisai W, Huo J, Zhou D, Zahradnik J, Supasa P, Liu C, Duyvesteyn HME, Ginn HM, Mentzer AJ, Tuekprakhon A, Nutalai R, Wang B, Dijokaite A, Khan S, Avinoam O, Bahar M, Skelly D, Adele S, Johnson SA, Amini A, Ritter TG, Mason C, Dold C, Pan D, Assadi S, Bellass A, Omo-Dare N, Koeckerling D, Flaxman A, Jenkin D, Aley PK, Voysey M, Costa Clemens SA, Naveca FG, Nascimento V, Nascimento F, Fernandes da Costa C, Resende PC, Pauvolid-Correa A, Siqueira MM, Baillie V, Serafin N, Kwatra G, Da Silva K, Madhi SA, Nunes MC, Malik T, Openshaw PJM, Baillie JK, Semple MG, Townsend AR, Huang KA, Tan TK, Carroll MW, Klenerman P, Barnes E, Dunachie SJ, Constantinides B, Webster H, Crook D, Pollard AJ, Lambe T, Paterson NG, Williams MA, Hall DR, Fry EE, Mongkolsapaya J, Ren J, Schreiber G, Stuart DI, Screaton GR. Cell. 2022 Feb 3;185(3):467-484.e15. doi: 10.1016/j.cell.2021.12.046. Epub 2022 Jan 4. PubMed |
| De novo expression of gastrokines in pancreatic precursor lesions impede the development of pancreatic cancer. Steiner S, Seleznik GM, Reding T, Stopic M, Lenggenhager D, Ten Buren E, Eshmuminov D, Endhardt K, Hagedorn C, Heidenblut AM, Bratus-Neuenschwander A, Grossmann J, Trachsel C, Jabbar KS, Hahn SA, Berg JV, Graf R, Gupta A. Oncogene. 2022 Mar;41(10):1507-1517. doi: 10.1038/s41388-022-02182-4. Epub 2022 Jan 26. PubMed |
| Isolation and characterization of the immune cell fraction from murine brain tumor microenvironment. Mastandrea I, Sher D, Magod P, Friedmann-Morvinski D. STAR Protoc. 2022 Jan 20;3(1):101106. doi: 10.1016/j.xpro.2021.101106. eCollection 2022 Mar 18. PubMed |
| Aberrant expression of claudin-6 contributes to malignant potentials and drug resistance of cervical adenocarcinoma. Ito Y, Takasawa A, Takasawa K, Murakami T, Akimoto T, Kyuno D, Kawata Y, Shano K, Kirisawa K, Ota M, Aoyama T, Murata M, Sugimoto K, Chiba H, Saito T, Osanai M. Cancer Sci. 2022 Apr;113(4):1519-1530. doi: 10.1111/cas.15284. Epub 2022 Feb 13. PubMed |
| Inhibition of Orai Channel Function Regulates Mas-Related G Protein-Coupled Receptor-Mediated Responses in Mast Cells. Chaki S, Alkanfari I, Roy S, Amponnawarat A, Hui Y, Oskeritzian CA, Ali H. Front Immunol. 2022 Jan 20;12:803335. doi: 10.3389/fimmu.2021.803335. eCollection 2021. PubMed |
| A human antibody reveals a conserved site on beta-coronavirus spike proteins and confers protection against SARS-CoV-2 infection. Zhou P, Yuan M, Song G, Beutler N, Shaabani N, Huang D, He WT, Zhu X, Callaghan S, Yong P, Anzanello F, Peng L, Ricketts J, Parren M, Garcia E, Rawlings SA, Smith DM, Nemazee D, Teijaro JR, Rogers TF, Wilson IA, Burton DR, Andrabi R. Sci Transl Med. 2022 Mar 23;14(637):eabi9215. doi: 10.1126/scitranslmed.abi9215. Epub 2022 Mar 23. PubMed |
| Pathway-specific effects of ADSL deficiency on neurodevelopment. Dutto I, Gerhards J, Herrera A, Souckova O, Skopova V, Smak JA, Junza A, Yanes O, Boeckx C, Burkhalter MD, Zikanova M, Pons S, Philipp M, Luders J, Stracker TH. Elife. 2022 Feb 8;11. pii: 70518. doi: 10.7554/eLife.70518. PubMed |
| Upregulation of CD14 in mesenchymal stromal cells accelerates lipopolysaccharide-induced response and enhances antibacterial properties. Hirakawa MP, Tjahjono N, Light YK, Celebi AN, Celebi NN, Chintalapudi P, Butler KS, Branda SS, Krishnakumar R. iScience. 2022 Jan 12;25(2):103759. doi: 10.1016/j.isci.2022.103759. eCollection 2022 Feb 18. PubMed |
| A protease-activatable luminescent biosensor and reporter cell line for authentic SARS-CoV-2 infection. Gerber PP, Duncan LM, Greenwood EJ, Marelli S, Naamati A, Teixeira-Silva A, Crozier TW, Gabaev I, Zhan JR, Mulroney TE, Horner EC, Doffinger R, Willis AE, Thaventhiran JE, Protasio AV, Matheson NJ. PLoS Pathog. 2022 Feb 10;18(2):e1010265. doi: 10.1371/journal.ppat.1010265. eCollection 2022 Feb. PubMed |
| Phosphorylation of guanosine monophosphate reductase triggers a GTP-dependent switch from pro- to anti-oncogenic function of EPHA4. Wolff DW, Deng Z, Bianchi-Smiraglia A, Foley CE, Han Z, Wang X, Shen S, Rosenberg MM, Moparthy S, Yun DH, Chen J, Baker BK, Roll MV, Magiera AJ, Li J, Hurley E, Feltri ML, Cox AO, Lee J, Furdui CM, Liu L, Bshara W, LaConte LEW, Kandel ES, Pasquale EB, Qu J, Hedstrom L, Nikiforov MA. Cell Chem Biol. 2022 Jun 16;29(6):970-984.e6. doi: 10.1016/j.chembiol.2022.01.007. Epub 2022 Feb 10. PubMed |
| DNA methyltransferase 1 (DNMT1) suppresses mitophagy and aggravates heart failure via the microRNA-152-3p/ETS1/RhoH axis. Deng Z, Yao J, Xiao N, Han Y, Wu X, Ci C, Chen K, Geng X. Lab Invest. 2022 Aug;102(8):782-793. doi: 10.1038/s41374-022-00740-8. Epub 2022 Feb 11. PubMed |
| Ferritin-Nanocaged ATP Traverses the Blood-Testis Barrier and Enhances Sperm Motility in an Asthenozoospermia Model. Pang J, Feng X, Liang Q, Zheng X, Duan Y, Zhang X, Zhang J, Chen Y, Fan K, Gao L, Li J. ACS Nano. 2022 Mar 22;16(3):4175-4185. doi: 10.1021/acsnano.1c10029. Epub 2022 Feb 15. PubMed |
| Development of human alveolar epithelial cell models to study distal lung biology and disease. Tran E, Shi T, Li X, Chowdhury AY, Jiang D, Liu Y, Wang H, Yan C, Wallace WD, Lu R, Ryan AL, Marconett CN, Zhou B, Borok Z, Offringa IA. iScience. 2022 Jan 15;25(2):103780. doi: 10.1016/j.isci.2022.103780. eCollection 2022 Feb 18. PubMed |
| TBK1-METTL3 axis facilitates antiviral immunity. Chen J, Wei X, Wang X, Liu T, Zhao Y, Chen L, Luo Y, Du H, Li Y, Liu T, Cao L, Zhou Z, Zhang Z, Liang L, Li L, Yan X, Zhang X, Deng X, Yang G, Yin P, Hao J, Yin Z, You F. Cell Rep. 2022 Feb 15;38(7):110373. doi: 10.1016/j.celrep.2022.110373. PubMed |
| CHCHD2 and CHCHD10 regulate mitochondrial dynamics and integrated stress response. Ruan Y, Hu J, Che Y, Liu Y, Luo Z, Cheng J, Han Q, He H, Zhou Q. Cell Death Dis. 2022 Feb 16;13(2):156. doi: 10.1038/s41419-022-04602-5. PubMed |
| Deletion of beta-Neurexins in Mice Alters the Distribution of Dense-Core Vesicles in Presynapses of Hippocampal and Cerebellar Neurons. Ferdos S, Brockhaus J, Missler M, Rohlmann A. Front Neuroanat. 2022 Jan 31;15:757017. doi: 10.3389/fnana.2021.757017. eCollection 2021. PubMed |
| Circular RNA ANAPC7 Inhibits Tumor Growth and Muscle Wasting via PHLPP2-AKT-TGF-beta Signaling Axis in Pancreatic Cancer. Shi X, Yang J, Liu M, Zhang Y, Zhou Z, Luo W, Fung KM, Xu C, Bronze MS, Houchen CW, Li M. Gastroenterology. 2022 Jun;162(7):2004-2017.e2. doi: 10.1053/j.gastro.2022.02.017. Epub 2022 Feb 14. PubMed |
| PKP1 and MYC create a feedforward loop linking transcription and translation in squamous cell lung cancer. Boyero L, Martin-Padron J, Farez-Vidal ME, Rodriguez MI, Andrades A, Peinado P, Arenas AM, Ritore-Salazar F, Alvarez-Perez JC, Cuadros M, Medina PP. Cell Oncol (Dordr). 2022 Apr;45(2):323-332. doi: 10.1007/s13402-022-00660-1. Epub 2022 Feb 19. PubMed |
| P2Y1 purinergic receptor identified as a diabetes target in a small-molecule screen to reverse circadian beta-cell failure. Marcheva B, Weidemann BJ, Taguchi A, Perelis M, Ramsey KM, Newman MV, Kobayashi Y, Omura C, Manning Fox JE, Lin H, Macdonald PE, Bass J. Elife. 2022 Feb 21;11. pii: 75132. doi: 10.7554/eLife.75132. PubMed |
| Mechanistic impact of oligomer poisoning by dominant-negative CARD11 variants. Bedsaul JR, Shah N, Hutcherson SM, Pomerantz JL. iScience. 2022 Jan 22;25(2):103810. doi: 10.1016/j.isci.2022.103810. eCollection 2022 Feb 18. PubMed |
| A novel mechanism for NLRP3 inflammasome activation. Zhang T, Zhao J, Liu T, Cheng W, Wang Y, Ding S, Wang R. Metabol Open. 2022 Jan 22;13:100166. doi: 10.1016/j.metop.2022.100166. eCollection 2022 Mar. PubMed |
| The Solute Carrier MFSD1 Decreases the Activation Status of beta1 Integrin and Thus Tumor Metastasis. Roblek M, Bicher J, van Gogh M, Gyorgy A, Seebock R, Szulc B, Damme M, Olczak M, Borsig L, Siekhaus DE. Front Oncol. 2022 Feb 8;12:777634. doi: 10.3389/fonc.2022.777634. eCollection 2022. PubMed |
| Discovery of a potent cytotoxic agent that promotes G2/M phase cell cycle arrest and apoptosis in a malignant human pharyngeal squamous carcinoma cell line. Nuth M, Benakanakere MR, Ricciardi RP. Int J Oncol. 2022 Apr;60(4). pii: 41. doi: 10.3892/ijo.2022.5331. Epub 2022 Feb 25. PubMed |
| The Natural Chemotherapeutic Capsaicin Activates AMPK through LKB1 Kinase and TRPV1 Receptors in Prostate Cancer Cells. Sanchez BG, Bort A, Mora-Rodriguez JM, Diaz-Laviada I. Pharmaceutics. 2022 Jan 29;14(2). pii: pharmaceutics14020329. doi: 10.3390/pharmaceutics14020329. PubMed |
| YAP regulates an SGK1/mTORC1/SREBP-dependent lipogenic program to support proliferation and tissue growth. Vaidyanathan S, Salmi TM, Sathiqu RM, McConville MJ, Cox AG, Brown KK. Dev Cell. 2022 Mar 28;57(6):719-731.e8. doi: 10.1016/j.devcel.2022.02.004. Epub 2022 Feb 24. PubMed |
| Glutamine-dependent signaling controls pluripotent stem cell fate. Lu V, Roy IJ, Torres A Jr, Joly JH, Ahsan FM, Graham NA, Teitell MA. Dev Cell. 2022 Mar 14;57(5):610-623.e8. doi: 10.1016/j.devcel.2022.02.003. Epub 2022 Feb 24. PubMed |
LKB1 drives stasis and C/EBP-mediated reprogramming to an alveolar type II fate in lung cancer.
Murray CW, Brady JJ, Han M, Cai H, Tsai MK, Pierce SE, Cheng R, Demeter J, Feldser DM, Jackson PK, Shackelford DB, Winslow MM.
Nat Commun. 2022 Feb 28;13(1):1090. doi: 10.1038/s41467-022-28619-8.
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| MLL::AF9 degradation induces rapid changes in transcriptional elongation and subsequent loss of an active chromatin landscape. Olsen SN, Godfrey L, Healy JP, Choi YA, Kai Y, Hatton C, Perner F, Haarer EL, Nabet B, Yuan GC, Armstrong SA. Mol Cell. 2022 Mar 17;82(6):1140-1155.e11. doi: 10.1016/j.molcel.2022.02.013. Epub 2022 Mar 3. PubMed |
| Confined migration promotes cancer metastasis through resistance to anoikis and increased invasiveness. Fanfone D, Wu Z, Mammi J, Berthenet K, Neves D, Weber K, Halaburkova A, Virard F, Bunel F, Jamard C, Hernandez-Vargas H, Tait SWG, Hennino A, Ichim G. Elife. 2022 Mar 8;11. pii: 73150. doi: 10.7554/eLife.73150. PubMed |
| Deletion of STAT3 from Foxd1 cell population protects mice from kidney fibrosis by inhibiting pericytes trans-differentiation and migration. Ajay AK, Zhao L, Vig S, Fujiwara M, Thakurela S, Jadhav S, Cho A, Chiu IJ, Ding Y, Ramachandran K, Mithal A, Bhatt A, Chaluvadi P, Gupta MK, Shah SI, Sabbisetti VS, Waaga-Gasser AM, Frank DA, Murugaiyan G, Bonventre JV, Hsiao LL. Cell Rep. 2022 Mar 8;38(10):110473. doi: 10.1016/j.celrep.2022.110473. PubMed |
| Novel mutation of SIK1 gene causing a mild form of pediatric epilepsy in a Chinese patient. Xu W, Zhang W, Cui L, Shi L, Zhu B, Lyu TJ, Ma W. Metab Brain Dis. 2022 Apr;37(4):1207-1219. doi: 10.1007/s11011-022-00943-4. Epub 2022 Mar 10. PubMed |
| TRIM24 promotes colorectal cancer cell progression via the Wnt/beta-catenin signaling pathway activation. Tian H, Zhao H, Qu B, Chu X, Xin X, Zhang Q, Li W, Yang S. Am J Transl Res. 2022 Feb 15;14(2):831-848. eCollection 2022. PubMed |
| H-ABC- and dystonia-causing TUBB4A mutations show distinct pathogenic effects. Krajka V, Vulinovic F, Genova M, Tanzer K, Jijumon AS, Bodakuntla S, Tennstedt S, Mueller-Fielitz H, Meier B, Janke C, Klein C, Rakovic A. Sci Adv. 2022 Mar 11;8(10):eabj9229. doi: 10.1126/sciadv.abj9229. Epub 2022 Mar 11. PubMed |
| Muller glia fused with adult stem cells undergo neural differentiation in human retinal models. Bonilla-Pons SA, Nakagawa S, Bahima EG, Fernandez-Blanco A, Pesaresi M, D'Antin JC, Sebastian-Perez R, Greco D, Dominguez-Sala E, Gomez-Riera R, Compte RIB, Dierssen M, Pulido NM, Cosma MP. EBioMedicine. 2022 Mar;77:103914. doi: 10.1016/j.ebiom.2022.103914. Epub 2022 Mar 9. PubMed |
Benchmarking of SpCas9 variants enables deeper base editor screens of BRCA1 and BCL2.
Sangree AK, Griffith AL, Szegletes ZM, Roy P, DeWeirdt PC, Hegde M, McGee AV, Hanna RE, Doench JG.
Nat Commun. 2022 Mar 14;13(1):1318. doi: 10.1038/s41467-022-28884-7.
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| Immunoaffinity Purification of Epitope-Tagged DNA Repair Complexes from Human Cells. Townley BA, Soll JM, Mosammaparast N. Methods Mol Biol. 2022;2444:29-41. doi: 10.1007/978-1-0716-2063-2_3. PubMed |
Broadly neutralizing anti-S2 antibodies protect against all three human betacoronaviruses that cause deadly disease.
Zhou P, Song G, Liu H, Yuan M, He WT, Beutler N, Zhu X, Tse LV, Martinez DR, Schafer A, Anzanello F, Yong P, Peng L, Dueker K, Musharrafieh R, Callaghan S, Capozzola T, Limbo O, Parren M, Garcia E, Rawlings SA, Smith DM, Nemazee D, Jardine JG, Safonova Y, Briney B, Rogers TF, Wilson IA, Baric RS, Gralinski LE, Burton DR, Andrabi R.
Immunity. 2023 Mar 14;56(3):669-686.e7. doi: 10.1016/j.immuni.2023.02.005. Epub 2023 Feb 16.
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In vivo prime editing of a metabolic liver disease in mice.
Bock D, Rothgangl T, Villiger L, Schmidheini L, Matsushita M, Mathis N, Ioannidi E, Rimann N, Grisch-Chan HM, Kreutzer S, Kontarakis Z, Kopf M, Thony B, Schwank G.
Sci Transl Med. 2022 Mar 16;14(636):eabl9238. doi: 10.1126/scitranslmed.abl9238. Epub 2022 Mar 16.
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| VIVA1: a more invasive subclone of MDA-MB-134VI invasive lobular carcinoma cells with increased metastatic potential in xenograft models. Allen V, Coulombe J, Zhao H, Kreps LM, Cook DP, Pryce B, Clemons M, Vanderhyden BC, Gray DA, Addison CL. Br J Cancer. 2022 Jul;127(1):56-68. doi: 10.1038/s41416-022-01778-7. Epub 2022 Mar 22. PubMed |
| Orthogonally induced differentiation of stem cells for the programmatic patterning of vascularized organoids and bioprinted tissues. Skylar-Scott MA, Huang JY, Lu A, Ng AHM, Duenki T, Liu S, Nam LL, Damaraju S, Church GM, Lewis JA. Nat Biomed Eng. 2022 Apr;6(4):449-462. doi: 10.1038/s41551-022-00856-8. Epub 2022 Mar 24. PubMed |
| Crystal structure and cellular functions of uPAR dimer. Yu S, Sui Y, Wang J, Li Y, Li H, Cao Y, Chen L, Jiang L, Yuan C, Huang M. Nat Commun. 2022 Mar 29;13(1):1665. doi: 10.1038/s41467-022-29344-y. PubMed |
| Genome-wide analysis of haploinsufficiency in human embryonic stem cells. Sarel-Gallily R, Golan-Lev T, Yilmaz A, Sagi I, Benvenisty N. Cell Rep. 2022 Mar 29;38(13):110573. doi: 10.1016/j.celrep.2022.110573. PubMed |
| Dual-gRNA approach with limited off-target effect corrects C9ORF72 repeat expansion in vivo. Piao X, Meng D, Zhang X, Song Q, Lv H, Jia Y. Sci Rep. 2022 Apr 5;12(1):5672. doi: 10.1038/s41598-022-07746-8. PubMed |
| Enhanced anti-angiogenetic effect of transferrin receptor-mediated delivery of VEGF-trap in a glioblastoma mouse model. Zhao P, Anami Y, Gao P, Fan X, Li L, Tsuchikama K, Zhang N, An Z. MAbs. 2022 Jan-Dec;14(1):2057269. doi: 10.1080/19420862.2022.2057269. PubMed |
| A Novel Sushi-IL15-PD1 CAR-NK92 Cell Line With Enhanced and PD-L1 Targeted Cytotoxicity Against Pancreatic Cancer Cells. Xu DL, He YQ, Xiao B, Si Y, Shi J, Liu XA, Tian L, Ren Q, Wu YS, Zhu Y. Front Oncol. 2022 Mar 22;12:726985. doi: 10.3389/fonc.2022.726985. eCollection 2022. PubMed |
| When killers become thieves: Trogocytosed PD-1 inhibits NK cells in cancer. Hasim MS, Marotel M, Hodgins JJ, Vulpis E, Makinson OJ, Asif S, Shih HY, Scheer AK, MacMillan O, Alonso FG, Burke KP, Cook DP, Li R, Petrucci MT, Santoni A, Fallon PG, Sharpe AH, Sciume G, Veillette A, Zingoni A, Gray DA, McCurdy A, Ardolino M. Sci Adv. 2022 Apr 15;8(15):eabj3286. doi: 10.1126/sciadv.abj3286. Epub 2022 Apr 13. PubMed |
| The interferon-stimulated gene RIPK1 regulates cancer cell intrinsic and extrinsic resistance to immune checkpoint blockade. Cucolo L, Chen Q, Qiu J, Yu Y, Klapholz M, Budinich KA, Zhang Z, Shao Y, Brodsky IE, Jordan MS, Gilliland DG, Zhang NR, Shi J, Minn AJ. Immunity. 2022 Apr 12;55(4):671-685.e10. doi: 10.1016/j.immuni.2022.03.007. PubMed |
| The nuclear lamina binds the EBV genome during latency and regulates viral gene expression. Caruso LB, Guo R, Keith K, Madzo J, Maestri D, Boyle S, Wasserman J, Kossenkov A, Gewurz BE, Tempera I. PLoS Pathog. 2022 Apr 14;18(4):e1010400. doi: 10.1371/journal.ppat.1010400. eCollection 2022 Apr. PubMed |
| Functional elements of the cis-regulatory lincRNA-p21. Winkler L, Jimenez M, Zimmer JT, Williams A, Simon MD, Dimitrova N. Cell Rep. 2022 Apr 19;39(3):110687. doi: 10.1016/j.celrep.2022.110687. PubMed |
| Mitochondrial dynamics regulate genome stability via control of caspase-dependent DNA damage. Cao K, Riley JS, Heilig R, Montes-Gomez AE, Vringer E, Berthenet K, Cloix C, Elmasry Y, Spiller DG, Ichim G, Campbell KJ, Gilmore AP, Tait SWG. Dev Cell. 2022 May 23;57(10):1211-1225.e6. doi: 10.1016/j.devcel.2022.03.019. Epub 2022 Apr 20. PubMed |
| Selective ferroptosis vulnerability due to familial Alzheimer's disease presenilin mutations. Greenough MA, Lane DJR, Balez R, Anastacio HTD, Zeng Z, Ganio K, McDevitt CA, Acevedo K, Belaidi AA, Koistinaho J, Ooi L, Ayton S, Bush AI. Cell Death Differ. 2022 Apr 21. pii: 10.1038/s41418-022-01003-1. doi: 10.1038/s41418-022-01003-1. PubMed |
The nuclear receptor THRB facilitates differentiation of human PSCs into more mature hepatocytes.
Ma H, de Zwaan E, Guo YE, Cejas P, Thiru P, van de Bunt M, Jeppesen JF, Syamala S, Dall'Agnese A, Abraham BJ, Fu D, Garrett-Engele C, Lee TI, Long HW, Griffith LG, Young RA, Jaenisch R.
Cell Stem Cell. 2022 Apr 13. pii: S1934-5909(22)00150-3. doi: 10.1016/j.stem.2022.03.015.
PubMed
Associated Plasmids |
| Oncohistone Mutations Occur at Functional Sites of Regulatory ADP-Ribosylation. Huang D, Camacho CV, Martire S, Nagari A, Setlem R, Gong X, Edwards AD, Chiu SP, Banaszynski LA, Kraus WL. Cancer Res. 2022 Jul 5;82(13):2361-2377. doi: 10.1158/0008-5472.CAN-22-0742. PubMed |
| GEM-IL: A highly responsive fluorescent lactate indicator. Bekdash R, Quejada JR, Ueno S, Kawano F, Morikawa K, Klein AD, Matsumoto K, Lee TC, Nakanishi K, Chalan A, Lee TM, Liu R, Homma S, Lin CS, Yelshanskaya MV, Sobolevsky AI, Goda K, Yazawa M. Cell Rep Methods. 2021 Oct 21;1(7):100092. doi: 10.1016/j.crmeth.2021.100092. eCollection 2021 Nov 22. PubMed |
| Genomewide CRISPR knockout screen identified PLAC8 as an essential factor for SADS-CoVs infection. Tse LV, Meganck RM, Araba KC, Yount BL, Shaffer KM, Hou YJ, Munt JE, Adams LE, Wykoff JA, Morowitz JM, Dong S, Magness ST, Marzluff WF, Gonzalez LM, Ehre C, Baric RS. Proc Natl Acad Sci U S A. 2022 May 3;119(18):e2118126119. doi: 10.1073/pnas.2118126119. Epub 2022 Apr 27. PubMed |
| Hypoxic, glycolytic metabolism is a vulnerability of B-acute lymphoblastic leukemia-initiating cells. Morris V, Wang D, Li Z, Marion W, Hughes T, Sousa P, Harada T, Sui SH, Naumenko S, Kalfon J, Sensharma P, Falchetti M, Vinicius da Silva R, Candelli T, Schneider P, Margaritis T, Holstege FCP, Pikman Y, Harris M, Stam RW, Orkin SH, Koehler AN, Shalek AK, North TE, Pimkin M, Daley GQ, Lummertz da Rocha E, Rowe RG. Cell Rep. 2022 Apr 26;39(4):110752. doi: 10.1016/j.celrep.2022.110752. PubMed |
| ASCL1 activates neuronal stem cell-like lineage programming through remodeling of the chromatin landscape in prostate cancer. Nouruzi S, Ganguli D, Tabrizian N, Kobelev M, Sivak O, Namekawa T, Thaper D, Baca SC, Freedman ML, Aguda A, Davies A, Zoubeidi A. Nat Commun. 2022 Apr 27;13(1):2282. doi: 10.1038/s41467-022-29963-5. PubMed |
| Polarity protein SCRIB interacts with SLC3A2 to regulate proliferation and tamoxifen resistance in ER+ breast cancer. Saito Y, Matsuda S, Ohnishi N, Endo K, Ashitani S, Ohishi M, Ueno A, Tomita M, Ueda K, Soga T, Muthuswamy SK. Commun Biol. 2022 May 2;5(1):403. doi: 10.1038/s42003-022-03363-3. PubMed |
| Combinatorial Treatment with PARP-1 Inhibitors and Cisplatin Attenuates Cervical Cancer Growth through Fos-Driven Changes in Gene Expression. Gupte R, Lin KY, Nandu T, Lea JS, Kraus WL. Mol Cancer Res. 2022 Aug 5;20(8):1183-1192. doi: 10.1158/1541-7786.MCR-22-0111. PubMed |
| Loss of PRMT7 reprograms glycine metabolism to selectively eradicate leukemia stem cells in CML. Liu C, Zou W, Nie D, Li S, Duan C, Zhou M, Lai P, Yang S, Ji S, Li Y, Mei M, Bao S, Jin Y, Pan J. Cell Metab. 2022 Jun 7;34(6):818-835.e7. doi: 10.1016/j.cmet.2022.04.004. Epub 2022 May 3. PubMed |
| Combinatorial GxGxE CRISPR screen identifies SLC25A39 in mitochondrial glutathione transport linking iron homeostasis to OXPHOS. Shi X, Reinstadler B, Shah H, To TL, Byrne K, Summer L, Calvo SE, Goldberger O, Doench JG, Mootha VK, Shen H. Nat Commun. 2022 May 5;13(1):2483. doi: 10.1038/s41467-022-30126-9. PubMed |
Comparative optimization of combinatorial CRISPR screens.
Li R, Klingbeil O, Monducci D, Young MJ, Rodriguez DJ, Bayyat Z, Dempster JM, Kesar D, Yang X, Zamanighomi M, Vakoc CR, Ito T, Sellers WR.
Nat Commun. 2022 May 5;13(1):2469. doi: 10.1038/s41467-022-30196-9.
PubMed
Associated Plasmids |
| SARS-CoV-2 Employ BSG/CD147 and ACE2 Receptors to Directly Infect Human Induced Pluripotent Stem Cell-Derived Kidney Podocytes. Kalejaiye TD, Bhattacharya R, Burt MA, Travieso T, Okafor AE, Mou X, Blasi M, Musah S. Front Cell Dev Biol. 2022 Apr 20;10:855340. doi: 10.3389/fcell.2022.855340. eCollection 2022. PubMed |
| Lymph node colonization induces tumor-immune tolerance to promote distant metastasis. Reticker-Flynn NE, Zhang W, Belk JA, Basto PA, Escalante NK, Pilarowski GOW, Bejnood A, Martins MM, Kenkel JA, Linde IL, Bagchi S, Yuan R, Chang S, Spitzer MH, Carmi Y, Cheng J, Tolentino LL, Choi O, Wu N, Kong CS, Gentles AJ, Sunwoo JB, Satpathy AT, Plevritis SK, Engleman EG. Cell. 2022 May 26;185(11):1924-1942.e23. doi: 10.1016/j.cell.2022.04.019. Epub 2022 May 6. PubMed |
| Comprehensive Target Screening and Cellular Profiling of the Cancer-Active Compound b-AP15 Indicate Abrogation of Protein Homeostasis and Organelle Dysfunction as the Primary Mechanism of Action. Gubat J, Selvaraju K, Sjostrand L, Kumar Singh D, Turkina MV, Schmierer B, Sabatier P, Zubarev RA, Linder S, D'Arcy P. Front Oncol. 2022 Apr 22;12:852980. doi: 10.3389/fonc.2022.852980. eCollection 2022. PubMed |
| C/EBPdelta-induced epigenetic changes control the dynamic gene transcription of S100a8 and S100a9. Jauch-Speer SL, Herrera-Rivero M, Ludwig N, Veras De Carvalho BC, Martens L, Wolf J, Imam Chasan A, Witten A, Markus B, Schieffer B, Vogl T, Rossaint J, Stoll M, Roth J, Fehler O. Elife. 2022 May 11;11:e75594. doi: 10.7554/eLife.75594. PubMed |
| Acquired chemoresistance drives spatial heterogeneity, chemoprotection and collective migration in pancreatic tumor spheroids. Thege FI, Cardle II, Gruber CN, Siemann MJ, Cong S, Wittmann K, Love J, Kirby BJ. PLoS One. 2022 May 26;17(5):e0267882. doi: 10.1371/journal.pone.0267882. eCollection 2022. PubMed |
| Loss of SP-A in the Lung Exacerbates Pulmonary Fibrosis. Kim K, Shin D, Lee G, Bae H. Int J Mol Sci. 2022 May 10;23(10). pii: ijms23105292. doi: 10.3390/ijms23105292. PubMed |
| SAFA facilitates chromatin opening of immune genes through interacting with anti-viral host RNAs. Cao L, Luo Y, Guo X, Liu S, Li S, Li J, Zhang Z, Zhao Y, Zhang Q, Gao F, Ji X, Gao X, Li Y, You F. PLoS Pathog. 2022 Jun 3;18(6):e1010599. doi: 10.1371/journal.ppat.1010599. eCollection 2022 Jun. PubMed |
| Proteomic and functional analyses of the periodic membrane skeleton in neurons. Zhou R, Han B, Nowak R, Lu Y, Heller E, Xia C, Chishti AH, Fowler VM, Zhuang X. Nat Commun. 2022 Jun 9;13(1):3196. doi: 10.1038/s41467-022-30720-x. PubMed |
| Membrane-Tethered Mucin 1 Is Stimulated by Interferon and Virus Infection in Multiple Cell Types and Inhibits Influenza A Virus Infection in Human Airway Epithelium. Iverson E, Griswold K, Song D, Gagliardi TB, Hamidzadeh K, Kesimer M, Sinha S, Perry M, Duncan GA, Scull MA. mBio. 2022 Aug 30;13(4):e0105522. doi: 10.1128/mbio.01055-22. Epub 2022 Jun 14. PubMed |
| Analysis of estrogen-regulated enhancer RNAs identifies a functional motif required for enhancer assembly and gene expression. Hou TY, Kraus WL. Cell Rep. 2022 Jun 14;39(11):110944. doi: 10.1016/j.celrep.2022.110944. PubMed |
| LILRB2-mediated TREM2 signaling inhibition suppresses microglia functions. Zhao P, Xu Y, Jiang LL, Fan X, Ku Z, Li L, Liu X, Deng M, Arase H, Zhu JJ, Huang TY, Zhao Y, Zhang C, Xu H, Tong Q, Zhang N, An Z. Mol Neurodegener. 2022 Jun 18;17(1):44. doi: 10.1186/s13024-022-00550-y. PubMed |
| KDM5A Inhibits Antitumor Immune Responses Through Downregulation of the Antigen-Presentation Pathway in Ovarian Cancer. Liu H, Lin J, Zhou W, Moses R, Dai Z, Kossenkov AV, Drapkin R, Bitler BG, Karakashev S, Zhang R. Cancer Immunol Res. 2022 Aug 3;10(8):1028-1038. doi: 10.1158/2326-6066.CIR-22-0088. PubMed |
| Lenalidomide bypasses CD28 co-stimulation to reinstate PD-1 immunotherapy by activating Notch signaling. Geng CL, Chen JY, Song TY, Jung JH, Long M, Song MF, Ji T, Min BS, Lee JG, Peng B, Pu YS, Fan HJ, Hao P, Zhou Q, Shin EC, Cang Y. Cell Chem Biol. 2022 Aug 18;29(8):1260-1272.e8. doi: 10.1016/j.chembiol.2022.05.012. Epub 2022 Jun 21. PubMed |
| A New Functional Screening Platform Identifies Colistin Sulfate as an Enhancer of Natural Killer Cell Cytotoxicity. Cortes-Kaplan S, Kurdieh R, Hasim MS, Kaczmarek S, Taha Z, Maznyi G, McComb S, Lee SH, Diallo JS, Ardolino M. Cancers (Basel). 2022 Jun 8;14(12). pii: cancers14122832. doi: 10.3390/cancers14122832. PubMed |
| Epigenomic analysis reveals a dynamic and context-specific macrophage enhancer landscape associated with innate immune activation and tolerance. Zhang P, Amarasinghe HE, Whalley JP, Tay C, Fang H, Migliorini G, Brown AC, Allcock A, Scozzafava G, Rath P, Davies B, Knight JC. Genome Biol. 2022 Jun 24;23(1):136. doi: 10.1186/s13059-022-02702-1. PubMed |
| RUNDC3A regulates SNAP25-mediated chemotherapy resistance by binding AKT in gastric neuroendocrine carcinoma (GNEC). Chen P, Wang W, Wong SW, Li J, Wu Q, Zhang SD, Lin Y, Kwok HF. Cell Death Discov. 2022 Jun 25;8(1):296. doi: 10.1038/s41420-022-01084-4. PubMed |
| The small GTPase RAB10 regulates endosomal recycling of the LDL receptor and transferrin receptor in hepatocytes. Khan TG, Ginsburg D, Emmer BT. J Lipid Res. 2022 Aug;63(8):100248. doi: 10.1016/j.jlr.2022.100248. Epub 2022 Jun 24. PubMed |
| Engagement of TRAIL triggers degranulation and IFNgamma production in human natural killer cells. Hofle J, Trenkner T, Kleist N, Schwane V, Vollmers S, Barcelona B, Niehrs A, Fittje P, Huynh-Tran VH, Sauter J, Schmidt AH, Peine S, Hoelzemer A, Richert L, Altfeld M, Korner C. EMBO Rep. 2022 Aug 3;23(8):e54133. doi: 10.15252/embr.202154133. Epub 2022 Jun 27. PubMed |
| Regulatory Programs of B-cell Activation and Germinal Center Reaction Allow B-ALL Escape from CD19 CAR T-cell Therapy. Im NG, Guillaumet-Adkins A, Wal M, Rogers AJ, Frede J, Havig CC, Yang J, Anand P, Stegmann SK, Waldschmidt JM, Sotudeh N, Niu L, Voisine J, Schweiger MR, Grassberger C, Lohr JG, Knoechel B. Cancer Immunol Res. 2022 Sep 1;10(9):1055-1068. doi: 10.1158/2326-6066.CIR-21-0626. PubMed |
Optimal LentiCRISPR-Based System for Sequential CRISPR/Cas9 Screens.
Hutcheson RL, Hayes M, Sugden B.
ACS Synth Biol. 2022 Jun 29. doi: 10.1021/acssynbio.2c00152.
PubMed
Associated Plasmids |
| Polo-Like Kinase 1 Regulates Chromosomal Instability and Paclitaxel Resistance in Breast Cancer Cells. Quan M, Oh Y, Cho SY, Kim JH, Moon HG. J Breast Cancer. 2022 Jun;25(3):178-192. doi: 10.4048/jbc.2022.25.e28. PubMed |
| Effects of stem cells and amniotic fluid on uterus and ovaries in a rat model of abdominal adhesions: a controlled study. Ganime Aygun E, Tumentemur G. J Turk Ger Gynecol Assoc. 2022 Sep 5;23(3):154-166. doi: 10.4274/jtgga.galenos.2022.2022-1-14. Epub 2022 Jul 5. PubMed |
| PRC2-Inactivating Mutations in Cancer Enhance Cytotoxic Response to DNMT1-Targeted Therapy via Enhanced Viral Mimicry. Patel AJ, Warda S, Maag JLV, Misra R, Miranda-Roman MA, Pachai MR, Lee CJ, Li D, Wang N, Bayshtok G, Fishinevich E, Meng Y, Wong EWP, Yan J, Giff E, Pappalardi MB, McCabe MT, Fletcher JA, Rudin CM, Chandarlapaty S, Scandura JM, Koche RP, Glass JL, Antonescu CR, Zheng D, Chen Y, Chi P. Cancer Discov. 2022 Sep 2;12(9):2120-2139. doi: 10.1158/2159-8290.CD-21-1671. PubMed |
Spatial regulation of AMPK signaling revealed by a sensitive kinase activity reporter.
Schmitt DL, Curtis SD, Lyons AC, Zhang JF, Chen M, He CY, Mehta S, Shaw RJ, Zhang J.
Nat Commun. 2022 Jul 5;13(1):3856. doi: 10.1038/s41467-022-31190-x.
PubMed
Associated Plasmids |
| Tumor suppressive functions of WNT5A in rhabdomyosarcoma. Ragab N, Bauer J, Uhmann A, Marx A, Hahn H, Simon-Keller K. Int J Oncol. 2022 Sep;61(3). pii: 102. doi: 10.3892/ijo.2022.5392. Epub 2022 Jul 7. PubMed |
| Integrated Stress Response Regulation of Corneal Epithelial Cell Motility and Cytokine Production. Chu HS, Peterson C, Chamling X, Berlinicke C, Zack D, Jun AS, Foster J. Invest Ophthalmol Vis Sci. 2022 Jul 8;63(8):1. doi: 10.1167/iovs.63.8.1. PubMed |
| Mast4 determines the cell fate of MSCs for bone and cartilage development. Kim P, Park J, Lee DJ, Mizuno S, Shinohara M, Hong CP, Jeong Y, Yun R, Park H, Park S, Yang KM, Lee MJ, Jang SP, Kim HY, Lee SJ, Song SU, Park KS, Tanaka M, Ohshima H, Cho JW, Sugiyama F, Takahashi S, Jung HS, Kim SJ. Nat Commun. 2022 Jul 8;13(1):3960. doi: 10.1038/s41467-022-31697-3. PubMed |
| Direct reprogramming of adult adipose-derived regenerative cells toward cardiomyocytes using six transcriptional factors. Narita S, Unno K, Kato K, Okuno Y, Sato Y, Tsumura Y, Fujikawa Y, Shimizu Y, Hayashida R, Kondo K, Shibata R, Murohara T. iScience. 2022 Jun 24;25(7):104651. doi: 10.1016/j.isci.2022.104651. eCollection 2022 Jul 15. PubMed |
| Progerin-Induced Impairment in Wound Healing and Proliferation in Vascular Endothelial Cells. Jiang Y, Ji JY. Front Aging. 2022 Mar 14;3:844885. doi: 10.3389/fragi.2022.844885. eCollection 2022. PubMed |
| Structural basis for acyl chain control over glycosphingolipid sorting and vesicular trafficking. Schmieder SS, Tatituri R, Anderson M, Kelly K, Lencer WI. Cell Rep. 2022 Jul 12;40(2):111063. doi: 10.1016/j.celrep.2022.111063. PubMed |
| Decline of humoral immune responses after natural SARS-CoV-2 infection can be efficiently reversed by vaccination. Oktelik FB, Yilmaz V, Gelmez MY, Akdeniz N, Pamukcu C, Sutlu T, Kose M, Tuzun E, Deniz G. Can J Microbiol. 2022 Aug 1;68(8):543-550. doi: 10.1139/cjm-2022-0003. Epub 2022 Jul 19. PubMed |
| Intronic Cis-Element DR8 in hTERT Is Bound by Splicing Factor SF3B4 and Regulates hTERT Splicing in Non-Small Cell Lung Cancer. Slusher AL, Kim JJ, Ribick M, Pollens-Voigt J, Bankhead A, Palmbos PL, Ludlow AT. Mol Cancer Res. 2022 Oct 4;20(10):1574-1588. doi: 10.1158/1541-7786.MCR-21-0058. PubMed |
| Nicotinamide riboside alleviates cisplatin-induced peripheral neuropathy via SIRT2 activation. Acklin S, Sadhukhan R, Du W, Patra M, Cholia R, Xia F. Neurooncol Adv. 2022 Jun 27;4(1):vdac101. doi: 10.1093/noajnl/vdac101. eCollection 2022 Jan-Dec. PubMed |
| Human papillomaviruses sensitize cells to DNA damage induced apoptosis by targeting the innate immune sensor cGAS. Gusho E, Laimins LA. PLoS Pathog. 2022 Jul 25;18(7):e1010725. doi: 10.1371/journal.ppat.1010725. eCollection 2022 Jul. PubMed |
| Inhibition of LSD1 with Bomedemstat Sensitizes Small Cell Lung Cancer to Immune Checkpoint Blockade and T-Cell Killing. Hiatt JB, Sandborg H, Garrison SM, Arnold HU, Liao SY, Norton JP, Friesen TJ, Wu F, Sutherland KD, Rienhoff HY, Martins R, Houghton AM, Srivastava S, MacPherson D. Clin Cancer Res. 2022 Oct 14;28(20):4551-4564. doi: 10.1158/1078-0432.CCR-22-1128. PubMed |
| Phenotypic heterogeneity driven by plasticity of the intermediate EMT state governs disease progression and metastasis in breast cancer. Brown MS, Abdollahi B, Wilkins OM, Lu H, Chakraborty P, Ognjenovic NB, Muller KE, Jolly MK, Christensen BC, Hassanpour S, Pattabiraman DR. Sci Adv. 2022 Aug 5;8(31):eabj8002. doi: 10.1126/sciadv.abj8002. Epub 2022 Aug 3. PubMed |
| Discovery and engineering of an anti-TREM2 antibody to promote amyloid plaque clearance by microglia in 5XFAD mice. Zhao P, Xu Y, Fan X, Li L, Li X, Arase H, Tong Q, Zhang N, An Z. MAbs. 2022 Jan-Dec;14(1):2107971. doi: 10.1080/19420862.2022.2107971. PubMed |
| Dolutegravir Inhibits Proliferation and Motility of BT-20 Tumor Cells Through Inhibition of Human Endogenous Retrovirus Type K. Li J, Lin J, Lin JR, Farris M, Robbins L, Andrada L, Grohol B, Nong S, Liu Y. Cureus. 2022 Jul 3;14(7):e26525. doi: 10.7759/cureus.26525. eCollection 2022 Jul. PubMed |
| Epigenetic reader SP140 loss of function drives Crohn's disease due to uncontrolled macrophage topoisomerases. Amatullah H, Fraschilla I, Digumarthi S, Huang J, Adiliaghdam F, Bonilla G, Wong LP, Rivard ME, Beauchamp C, Mercier V, Goyette P, Sadreyev RI, Anthony RM, Rioux JD, Jeffrey KL. Cell. 2022 Aug 18;185(17):3232-3247.e18. doi: 10.1016/j.cell.2022.06.048. Epub 2022 Aug 10. PubMed |
| Saturation of the mitochondrial NADH shuttles drives aerobic glycolysis in proliferating cells. Wang Y, Stancliffe E, Fowle-Grider R, Wang R, Wang C, Schwaiger-Haber M, Shriver LP, Patti GJ. Mol Cell. 2022 Sep 1;82(17):3270-3283.e9. doi: 10.1016/j.molcel.2022.07.007. Epub 2022 Aug 15. PubMed |
| Aberrant Cholesterol Metabolism and Wnt/beta-Catenin Signaling Coalesce via Frizzled5 in Supporting Cancer Growth. Zheng S, Lin J, Pang Z, Zhang H, Wang Y, Ma L, Zhang H, Zhang X, Chen M, Zhang X, Zhao C, Qi J, Cao L, Wang M, He X, Sheng R. Adv Sci (Weinh). 2022 Oct;9(28):e2200750. doi: 10.1002/advs.202200750. Epub 2022 Aug 17. PubMed |
| Stromal remodeling regulates dendritic cell abundance and activity in the tumor microenvironment. Papadas A, Deb G, Cicala A, Officer A, Hope C, Pagenkopf A, Flietner E, Morrow ZT, Emmerich P, Wiesner J, Arauz G, Bansal V, Esbona K, Capitini CM, Matkowskyj KA, Deming DA, Politi K, Abrams SI, Harismendy O, Asimakopoulos F. Cell Rep. 2022 Aug 16;40(7):111201. doi: 10.1016/j.celrep.2022.111201. PubMed |
Direct control of lysosomal catabolic activity by mTORC1 through regulation of V-ATPase assembly.
Ratto E, Chowdhury SR, Siefert NS, Schneider M, Wittmann M, Helm D, Palm W.
Nat Commun. 2022 Aug 17;13(1):4848. doi: 10.1038/s41467-022-32515-6.
PubMed
Associated Plasmids |
| Chromatin-bound RB targets promoters, enhancers, and CTCF-bound loci and is redistributed by cell-cycle progression. Sanidas I, Lee H, Rumde PH, Boulay G, Morris R, Golczer G, Stanzione M, Hajizadeh S, Zhong J, Ryan MB, Corcoran RB, Drapkin BJ, Rivera MN, Dyson NJ, Lawrence MS. Mol Cell. 2022 Sep 15;82(18):3333-3349.e9. doi: 10.1016/j.molcel.2022.07.014. Epub 2022 Aug 17. PubMed |
| Identification of a drug-response gene in multiple myeloma through longitudinal single-cell transcriptome sequencing. Masuda T, Haji S, Nakashima Y, Tsuda M, Kimura D, Takamatsu A, Iwahashi N, Umakoshi H, Shiratsuchi M, Kikutake C, Suyama M, Ohkawa Y, Ogawa Y. iScience. 2022 Jul 19;25(8):104781. doi: 10.1016/j.isci.2022.104781. eCollection 2022 Aug 19. PubMed |
| Kruppel-like factor 5 rewires NANOG regulatory network to activate human naive pluripotency specific LTR7Ys and promote naive pluripotency. Ai Z, Xiang X, Xiang Y, Szczerbinska I, Qian Y, Xu X, Ma C, Su Y, Gao B, Shen H, Bin Ramli MN, Chen D, Liu Y, Hao JJ, Ng HH, Zhang D, Chan YS, Liu W, Liang H. Cell Rep. 2022 Aug 23;40(8):111240. doi: 10.1016/j.celrep.2022.111240. PubMed |
| Defining the HIV Capsid Binding Site of Nucleoporin 153. Li S, Patel JS, Yang J, Crabtree AM, Rubenstein BM, Lund-Andersen PK, Ytreberg FM, Rowley PA. mSphere. 2022 Oct 26;7(5):e0031022. doi: 10.1128/msphere.00310-22. Epub 2022 Aug 30. PubMed |
| RBM45 is an m(6)A-binding protein that affects neuronal differentiation and the splicing of a subset of mRNAs. Choi SH, Flamand MN, Liu B, Zhu H, Hu M, Wang M, Sewell J, Holley CL, Al-Hashimi HM, Meyer KD. Cell Rep. 2022 Aug 30;40(9):111293. doi: 10.1016/j.celrep.2022.111293. PubMed |
| Accounting for small variations in the tracrRNA sequence improves sgRNA activity predictions for CRISPR screening. DeWeirdt PC, McGee AV, Zheng F, Nwolah I, Hegde M, Doench JG. Nat Commun. 2022 Sep 6;13(1):5255. doi: 10.1038/s41467-022-33024-2. PubMed |
| SHP2 regulates adipose maintenance and adipocyte-pancreatic cancer cell crosstalk via PDHA1. Olou AA, Ambrose J, Jack JL, Walsh M, Ruckert MT, Eades AE, Bye BA, Dandawate P, VanSaun MN. J Cell Commun Signal. 2022 Sep 8. doi: 10.1007/s12079-022-00691-1. PubMed |
| TRIM28 Is a Novel Regulator of CD133 Expression Associated with Cancer Stem Cell Phenotype. Kim YS, Potashnikova DM, Gisina AM, Kholodenko IV, Kopylov AT, Tikhonova OV, Kurbatov LK, Saidova AA, Tvorogova AV, Kholodenko RV, Belousov PV, Vorobjev IA, Zgoda VG, Yarygin KN, Lupatov AY. Int J Mol Sci. 2022 Aug 30;23(17):9874. doi: 10.3390/ijms23179874. PubMed |
| Development and Characterization of a Luciferase Labeled, Syngeneic Murine Model of Ovarian Cancer. Russell S, Lim F, Peters PN, Wardell SE, Whitaker R, Chang CY, Previs RA, McDonnell DP. Cancers (Basel). 2022 Aug 30;14(17):4219. doi: 10.3390/cancers14174219. PubMed |
| Transposon Mutagenesis Reveals RBMS3 Silencing as a Promoter of Malignant Progression of BRAFV600E-Driven Lung Tumorigenesis. Vaishnavi A, Juan J, Jacob M, Stehn C, Gardner EE, Scherzer MT, Schuman S, Van Veen JE, Murphy B, Hackett CS, Dupuy AJ, Chmura SA, van der Weyden L, Newberg JY, Liu A, Mann K, Rust AG, Weiss WA, Kinsey CG, Adams DJ, Grossmann A, Mann MB, McMahon M. Cancer Res. 2022 Nov 15;82(22):4261-4273. doi: 10.1158/0008-5472.CAN-21-3214. PubMed |
| Inhibition of O-GlcNAcase Inhibits Hematopoietic and Leukemic Stem Cell Self-Renewal and Drives Dendritic Cell Differentiation via STAT3/5 Signaling. Luanpitpong S, Rodboon N, Samart P, Janan M, Klaihmon P, Lorthongpanich C, U-Pratya Y, Issaragrisil S. Stem Cells. 2022 Dec 31;40(12):1078-1093. doi: 10.1093/stmcls/sxac068. PubMed |
| Meteorin links the bone marrow hypoxic state to hematopoietic stem/progenitor cell mobilization. Dai YW, Ma JK, Jiang R, Zhan XL, Chen SY, Feng LL, Zhang Q, Liang TB, Lv K, Yang GJ, Lu JF, Chen J, Lu XJ. Cell Rep. 2022 Sep 20;40(12):111361. doi: 10.1016/j.celrep.2022.111361. PubMed |
| UBE2T promotes glioblastoma malignancy through ubiquitination-mediated degradation of RPL6. Tao X, Wu X, Zhou P, Yu X, Zhao C, Peng X, Zhang K, Shen L, Peng J, Yang L. Cancer Sci. 2023 Feb;114(2):521-532. doi: 10.1111/cas.15604. Epub 2022 Oct 14. PubMed |
| A novel oncogenic enhancer of estrogen receptor-positive breast cancer. Bao C, Duan J, Xie Y, Liu Y, Li P, Li J, Zhao H, Guo H, Men Y, Ren Y, Xu J, Wang G, Lu W. Mol Ther Nucleic Acids. 2022 Aug 24;29:836-851. doi: 10.1016/j.omtn.2022.08.029. eCollection 2022 Sep 13. PubMed |
| The lncRNA ALPHA specifically targets chikungunya virus to control infection. Basavappa MG, Ferretti M, Dittmar M, Stoute J, Sullivan MC, Whig K, Shen H, Liu KF, Schultz DC, Beiting DP, Lynch KW, Henao-Mejia J, Cherry S. Mol Cell. 2022 Oct 6;82(19):3729-3744.e10. doi: 10.1016/j.molcel.2022.08.030. Epub 2022 Sep 26. PubMed |
| Induced retinal pigment epithelial cells with anti-epithelial-to-mesenchymal transition ability delay retinal degeneration. Tian H, Chen Z, Zhu X, Ou Q, Wang Z, Wu B, Xu JY, Jin C, Gao F, Wang J, Zhang J, Zhang J, Lu L, Xu GT. iScience. 2022 Sep 2;25(10):105050. doi: 10.1016/j.isci.2022.105050. eCollection 2022 Oct 21. PubMed |
| HIV-induced bystander cell death in astrocytes requires cell-to-cell viral transmission. Cevallos C, Ojeda DS, Sanchez L, Urquiza J, Delpino MV, Quarleri J. J Neurochem. 2022 Nov;163(4):338-356. doi: 10.1111/jnc.15703. Epub 2022 Oct 17. PubMed |
| Multiple centrosomes enhance migration and immune cell effector functions of mature dendritic cells. Weier AK, Homrich M, Ebbinghaus S, Juda P, Mikova E, Hauschild R, Zhang L, Quast T, Mass E, Schlitzer A, Kolanus W, Burgdorf S, Gruss OJ, Hons M, Wieser S, Kiermaier E. J Cell Biol. 2022 Dec 5;221(12):e202107134. doi: 10.1083/jcb.202107134. Epub 2022 Oct 10. PubMed |
| Thermal-exchange HLA-E multimers reveal specificity in HLA-E and NKG2A/CD94 complex interactions. Ruibal P, Derksen I, van Wolfswinkel M, Voogd L, Franken KLMC, El Hebieshy AF, van Hall T, Schoufour TAW, Wijdeven RH, Ottenhoff THM, Scheeren FA, Joosten SA. Immunology. 2023 Mar;168(3):526-537. doi: 10.1111/imm.13591. Epub 2022 Oct 20. PubMed |
| Angiotensin II receptor type 1 blockade regulates Klotho expression to induce TSC2-deficient cell death. Shrestha S, Adib E, Imani J, Aguiar DJ, Lamattina AM, Tassew DD, Henske EP, Perrella MA, Priolo C, El-Chemaly S. J Biol Chem. 2022 Nov;298(11):102580. doi: 10.1016/j.jbc.2022.102580. Epub 2022 Oct 8. PubMed |
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| A dominant negative mitofusin causes mitochondrial perinuclear clusters because of aberrant tethering. Sloat SR, Hoppins S. Life Sci Alliance. 2022 Oct 13;6(1):e202101305. doi: 10.26508/lsa.202101305. Print 2023 Jan. PubMed |
| NSP4 and ORF9b of SARS-CoV-2 Induce Pro-Inflammatory Mitochondrial DNA Release in Inner Membrane-Derived Vesicles. Faizan MI, Chaudhuri R, Sagar S, Albogami S, Chaudhary N, Azmi I, Akhtar A, Ali SM, Kumar R, Iqbal J, Joshi MC, Kharya G, Seth P, Roy SS, Ahmad T. Cells. 2022 Sep 23;11(19):2969. doi: 10.3390/cells11192969. PubMed |
| Therapy free of cells vs human mesenchymal stem cells from umbilical cord stroma to treat the inflammation in OA. Morente-Lopez M, Mato-Basalo R, Lucio-Gallego S, Silva-Fernandez L, Gonzalez-Rodriguez A, De Toro FJ, Fafian-Labora JA, Arufe MC. Cell Mol Life Sci. 2022 Oct 20;79(11):557. doi: 10.1007/s00018-022-04580-z. PubMed |
| Increased CaMKK2 Expression Is an Adaptive Response That Maintains the Fitness of Tumor-Infiltrating Natural Killer Cells. Juras PK, Racioppi L, Mukherjee D, Artham S, Gao X, Akullian D'Agostino L, Chang CY, McDonnell DP. Cancer Immunol Res. 2023 Jan 3;11(1):109-122. doi: 10.1158/2326-6066.CIR-22-0391. PubMed |
| TRIM59 guards ER proteostasis and prevents Bortezomib-mediated colorectal cancer (CRC) cells' killing. Feng X, Yang G, Zhang L, Tao S, Shim JS, Chen L, Wu Q. Invest New Drugs. 2022 Dec;40(6):1244-1253. doi: 10.1007/s10637-022-01306-7. Epub 2022 Oct 28. PubMed |
| Ferroptosis inhibition by lysosome-dependent catabolism of extracellular protein. Armenta DA, Laqtom NN, Alchemy G, Dong W, Morrow D, Poltorack CD, Nathanson DA, Abu-Remalieh M, Dixon SJ. Cell Chem Biol. 2022 Nov 17;29(11):1588-1600.e7. doi: 10.1016/j.chembiol.2022.10.006. Epub 2022 Oct 27. PubMed |
| Tumor-intrinsic SIRPA promotes sensitivity to checkpoint inhibition immunotherapy in melanoma. Zhou Z, Chen MM, Luo Y, Mojumdar K, Peng X, Chen H, Kumar SV, Akbani R, Lu Y, Liang H. Cancer Cell. 2022 Nov 14;40(11):1324-1340.e8. doi: 10.1016/j.ccell.2022.10.012. Epub 2022 Nov 3. PubMed |
| Loss of neuronal Tet2 enhances hippocampal-dependent cognitive function. Pratt KJB, Shea JM, Remesal-Gomez L, Bieri G, Smith LK, Couthouis J, Chen CP, Roy IJ, Gontier G, Villeda SA. Cell Rep. 2022 Nov 8;41(6):111612. doi: 10.1016/j.celrep.2022.111612. PubMed |
| NF1 loss of function as an alternative initiating event in pancreatic ductal adenocarcinoma. Ramakrishnan G, Parajuli P, Singh P, Friend C, Hurwitz E, Prunier C, Razzaque MS, Xu K, Atfi A. Cell Rep. 2022 Nov 8;41(6):111623. doi: 10.1016/j.celrep.2022.111623. PubMed |
| Frataxin deficiency alters gene expression in Friedreich ataxia derived IPSC-neurons and cardiomyocytes. Angulo MB, Bertalovitz A, Argenziano MA, Yang J, Patel A, Zesiewicz T, McDonald TV. Mol Genet Genomic Med. 2023 Jan;11(1):e2093. doi: 10.1002/mgg3.2093. Epub 2022 Nov 11. PubMed |
| Protocol to image and quantify nucleocytoplasmic transport in cultured cells using fluorescent in situ hybridization and a dual reporter system. Cui H, Sepehrimanesh M, Coutee CA, Akter M, Hosain MA, Ding B. STAR Protoc. 2022 Nov 3;3(4):101813. doi: 10.1016/j.xpro.2022.101813. eCollection 2022 Dec 16. PubMed |
| An mTORC1 to HRI signaling axis promotes cytotoxicity of proteasome inhibitors in multiple myeloma. Darawshi O, Muz B, Naamat SG, Praveen B, Mahameed M, Goldberg K, Dipta P, Shmuel M, Forno F, Boukeileh S, Pahima H, Hermann J, Raab MS, Poos AM, Weinhold N, Rosenbluh C, Gatt ME, Palm W, Azab AK, Tirosh B. Cell Death Dis. 2022 Nov 18;13(11):969. doi: 10.1038/s41419-022-05421-4. PubMed |
| The leucine-rich repeat (LRR) domain of NLRP3 is required for NLRP3 inflammasome activation in macrophages. Duan Y, Wang J, Cai J, Kelley N, He Y. J Biol Chem. 2022 Dec;298(12):102717. doi: 10.1016/j.jbc.2022.102717. Epub 2022 Nov 17. PubMed |
| Autophagy promotes cell survival by maintaining NAD levels. Kataura T, Sedlackova L, Otten EG, Kumari R, Shapira D, Scialo F, Stefanatos R, Ishikawa KI, Kelly G, Seranova E, Sun C, Maetzel D, Kenneth N, Trushin S, Zhang T, Trushina E, Bascom CC, Tasseff R, Isfort RJ, Oblong JE, Miwa S, Lazarou M, Jaenisch R, Imoto M, Saiki S, Papamichos-Chronakis M, Manjithaya R, Maddocks ODK, Sanz A, Sarkar S, Korolchuk VI. Dev Cell. 2022 Nov 21;57(22):2584-2598.e11. doi: 10.1016/j.devcel.2022.10.008. PubMed |
| MUC5B mobilizes and MUC5AC spatially aligns mucociliary transport on human airway epithelium. Song D, Iverson E, Kaler L, Boboltz A, Scull MA, Duncan GA. Sci Adv. 2022 Nov 25;8(47):eabq5049. doi: 10.1126/sciadv.abq5049. Epub 2022 Nov 25. PubMed |
| Combating Drug Resistance by Exploiting miRNA-200c-Controlled Phase II Detoxification. Kohler B, Dubovik S, Horterer E, Wilk U, Stockl JB, Tekarslan-Sahin H, Ljepoja B, Paulitschke P, Frohlich T, Wagner E, Roidl A. Cancers (Basel). 2022 Nov 11;14(22):5554. doi: 10.3390/cancers14225554. PubMed |
| Bcl-2 Family Members Bcl-xL and Bax Cooperatively Contribute to Bortezomib Resistance in Mantle Cell Lymphoma. Luanpitpong S, Janan M, Yosudjai J, Poohadsuan J, Chanvorachote P, Issaragrisil S. Int J Mol Sci. 2022 Nov 21;23(22):14474. doi: 10.3390/ijms232214474. PubMed |
| CEACAM1 is a direct SOX10 target and inhibits melanoma immune infiltration and stemness. Abou-Hamad J, Hodgins JJ, de Souza CT, Garland B, Labreche C, Marotel M, Gibson C, Delisle S, Pascoal J, Auer RC, Ardolino M, Sabourin LA. iScience. 2022 Nov 7;25(12):105524. doi: 10.1016/j.isci.2022.105524. eCollection 2022 Dec 22. PubMed |
| The Sall2 transcription factor promotes cell migration regulating focal adhesion turnover and integrin beta1 expression. Riffo E, Palma M, Hepp MI, Benitez-Riquelme D, Torres VA, Castro AF, Pincheira R. Front Cell Dev Biol. 2022 Nov 9;10:1031262. doi: 10.3389/fcell.2022.1031262. eCollection 2022. PubMed |
Glycine inhibits NINJ1 membrane clustering to suppress plasma membrane rupture in cell death.
Borges JP, Saetra RSR, Volchuk A, Bugge M, Devant P, Sporsheim B, Kilburn BR, Evavold CL, Kagan JC, Goldenberg NM, Flo TH, Steinberg BE.
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| Autophagy inhibition signals through senescence to promote tumor suppression. Peng N, Kang HH, Feng Y, Minikes AM, Jiang X. Autophagy. 2022 Dec 15:1-17. doi: 10.1080/15548627.2022.2155794. PubMed |
| Arginine-rich C9ORF72 ALS proteins stall ribosomes in a manner distinct from a canonical ribosome-associated quality control substrate. Kriachkov V, Ormsby AR, Kusnadi EP, McWilliam HEG, Mintern JD, Amarasinghe SL, Ritchie ME, Furic L, Hatters DM. J Biol Chem. 2023 Jan;299(1):102774. doi: 10.1016/j.jbc.2022.102774. Epub 2022 Dec 5. PubMed |
| Opa1 and Drp1 reciprocally regulate cristae morphology, ETC function, and NAD(+) regeneration in KRas-mutant lung adenocarcinoma. Sessions DT, Kim KB, Kashatus JA, Churchill N, Park KS, Mayo MW, Sesaki H, Kashatus DF. Cell Rep. 2022 Dec 13;41(11):111818. doi: 10.1016/j.celrep.2022.111818. PubMed |
| Heterogeneous nuclear ribonucleoprotein K is overexpressed in acute myeloid leukemia and causes myeloproliferation in mice via altered Runx1 splicing. Aitken MJL, Malaney P, Zhang X, Herbrich SM, Chan L, Benitez O, Rodriguez AG, Ma H, Jacamo R, Duan R, Link TM, Kornblau SM, Kanagal-Shamanna R, Bueso-Ramos CE, Post SM. NAR Cancer. 2022 Dec 9;4(4):zcac039. doi: 10.1093/narcan/zcac039. eCollection 2022 Dec. PubMed |
| Engineering inducible biomolecular assemblies for genome imaging and manipulation in living cells. Peng Q, Huang Z, Sun K, Liu Y, Yoon CW, Harrison RES, Schmitt DL, Zhu L, Wu Y, Tasan I, Zhao H, Zhang J, Zhong S, Chien S, Wang Y. Nat Commun. 2022 Dec 24;13(1):7933. doi: 10.1038/s41467-022-35504-x. PubMed |
| Identification of beta2 microglobulin, the product of B2M gene, as a Host Factor for Vaccinia Virus Infection by Genome-Wide CRISPR genetic screens. Matia A, Lorenzo MM, Romero-Estremera YC, Sanchez-Puig JM, Zaballos A, Blasco R. PLoS Pathog. 2022 Dec 27;18(12):e1010800. doi: 10.1371/journal.ppat.1010800. eCollection 2022 Dec. PubMed |
| Pyruvate kinase M2 mediates IL-17 signaling in keratinocytes driving psoriatic skin inflammation. Veras FP, Publio GA, Melo BM, Prado DS, Norbiato T, Cecilio NT, Hiroki C, Damasceno LEA, Jung R, Toller-Kawahisa JE, Martins TV, Assuncao SF, Lima D, Alves MG, Vieira GV, Tavares LA, Alves-Rezende ALR, Karbach SH, Nakaya HI, Cunha TM, Souza CS, Cunha FQ, Sales KU, Waisman A, Alves-Filho JC. Cell Rep. 2022 Dec 27;41(13):111897. doi: 10.1016/j.celrep.2022.111897. PubMed |
| Generation of Induced Pluripotent Stem Cells from Lymphoblastoid Cell Lines by Electroporation of Episomal Vectors. Kim M, Park J, Kim S, Han DW, Shin B, Scholer HR, Kim J, Kim KP. Int J Stem Cells. 2023 Feb 28;16(1):36-43. doi: 10.15283/ijsc22177. Epub 2022 Dec 31. PubMed |
| A novel intergenic enhancer that regulates Bdnf expression in developing cortical neurons. Brookes E, Martinez De La Cruz B, Boulasiki P, Au HYA, Varsally W, Barrington C, Hadjur S, Riccio A. iScience. 2022 Dec 1;26(1):105695. doi: 10.1016/j.isci.2022.105695. eCollection 2023 Jan 20. PubMed |
| Deletion of Bak1 alleviates microglial necroptosis and neuroinflammation after experimental subarachnoid hemorrhage. Qiu X, Tao Q, Zhang L, Kuang C, Xie Y, Zhang L, Yin S, Peng J, Jiang Y. J Neurochem. 2023 Mar;164(6):829-846. doi: 10.1111/jnc.15751. Epub 2023 Jan 7. PubMed |
| Gene regulatory network reconfiguration in direct lineage reprogramming. Kamimoto K, Adil MT, Jindal K, Hoffmann CM, Kong W, Yang X, Morris SA. Stem Cell Reports. 2023 Jan 10;18(1):97-112. doi: 10.1016/j.stemcr.2022.11.010. Epub 2022 Dec 29. PubMed |
| PAX8 modulates the tumor microenvironment of high grade serous ovarian cancer through changes in the secretome. Salvi A, Hardy LR, Heath KN, Watry S, Pergande MR, Cologna SM, Burdette JE. Neoplasia. 2023 Feb;36:100866. doi: 10.1016/j.neo.2022.100866. Epub 2022 Dec 29. PubMed |
| A delicate balance between antibody evasion and ACE2 affinity for Omicron BA.2.75. Huo J, Dijokaite-Guraliuc A, Liu C, Zhou D, Ginn HM, Das R, Supasa P, Selvaraj M, Nutalai R, Tuekprakhon A, Duyvesteyn HME, Mentzer AJ, Skelly D, Ritter TG, Amini A, Bibi S, Adele S, Johnson SA, Paterson NG, Williams MA, Hall DR, Plowright M, Newman TAH, Hornsby H, de Silva TI, Temperton N, Klenerman P, Barnes E, Dunachie SJ, Pollard AJ, Lambe T, Goulder P, Fry EE, Mongkolsapaya J, Ren J, Stuart DI, Screaton GR. Cell Rep. 2023 Jan 31;42(1):111903. doi: 10.1016/j.celrep.2022.111903. Epub 2022 Dec 14. PubMed |
| Behavioral context improves optogenetic stimulation of transplanted dopaminergic cells in unilateral 6-OHDA rats. Anderson KA, Whitehead BJ, Petersen ED, Kemme MR, Wedster A, Hochgeschwender U, Sandstrom MI. Behav Brain Res. 2023 Mar 12;441:114279. doi: 10.1016/j.bbr.2022.114279. Epub 2022 Dec 29. PubMed |
| Characterization of Sialic Acid-Independent Simian Rotavirus Mutants in Viral Infection and Pathogenesis. Yamasaki M, Kanai Y, Wakamura Y, Kotaki T, Minami S, Nouda R, Nurdin JA, Kobayashi T. J Virol. 2023 Jan 31;97(1):e0139722. doi: 10.1128/jvi.01397-22. Epub 2023 Jan 5. PubMed |
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CDT1 inhibits CMG helicase in early S phase to separate origin licensing from DNA synthesis.
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Mol Cell. 2023 Jan 5;83(1):26-42.e13. doi: 10.1016/j.molcel.2022.12.004.
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| Repeat-associated non-AUG translation induces cytoplasmic aggregation of CAG repeat-containing RNAs. Das MR, Chang Y, Anderson R, Saunders RA, Zhang N, Tomberlin CP, Vale RD, Jain A. Proc Natl Acad Sci U S A. 2023 Jan 17;120(3):e2215071120. doi: 10.1073/pnas.2215071120. Epub 2023 Jan 9. PubMed |
| Ectopic CH60 mediates HAPLN1-induced cell survival signaling in multiple myeloma. De Bakshi D, Chen YC, Wuerzberger-Davis SM, Ma M, Waters BJ, Li L, Suzuki A, Miyamoto S. Life Sci Alliance. 2022 Dec 13;6(3):e202201636. doi: 10.26508/lsa.202201636. Print 2023 Mar. PubMed |
| T cell-derived interleukin-22 drives the expression of CD155 by cancer cells to suppress NK cell function and promote metastasis. Briukhovetska D, Suarez-Gosalvez J, Voigt C, Markota A, Giannou AD, Schubel M, Jobst J, Zhang T, Dorr J, Markl F, Majed L, Muller PJ, May P, Gottschlich A, Tokarew N, Lucke J, Oner A, Schwerdtfeger M, Andreu-Sanz D, Grunmeier R, Seifert M, Michaelides S, Hristov M, Konig LM, Cadilha BL, Mikhaylov O, Anders HJ, Rothenfusser S, Flavell RA, Cerezo-Wallis D, Tejedo C, Soengas MS, Bald T, Huber S, Endres S, Kobold S. Immunity. 2023 Jan 10;56(1):143-161.e11. doi: 10.1016/j.immuni.2022.12.010. PubMed |
| Annexin A1 is a polarity cue that directs mitotic spindle orientation during mammalian epithelial morphogenesis. Fankhaenel M, Hashemi FSG, Mourao L, Lucas E, Hosawi MM, Skipp P, Morin X, Scheele CLGJ, Elias S. Nat Commun. 2023 Jan 11;14(1):151. doi: 10.1038/s41467-023-35881-x. PubMed |
| Trophoblast-specific knockdown of CSPG4 expression causes pregnancy complications with poor placentation in mice. Xu J, Yuan A, Su R, Yang Q, Fan X, Zhang J. Reprod Biol. 2023 Mar;23(1):100731. doi: 10.1016/j.repbio.2023.100731. Epub 2023 Jan 10. PubMed |
| A conditional Smg6 mutant mouse model reveals circadian clock regulation through the nonsense-mediated mRNA decay pathway. Katsioudi G, Dreos R, Arpa ES, Gaspari S, Liechti A, Sato M, Gabriel CH, Kramer A, Brown SA, Gatfield D. Sci Adv. 2023 Jan 13;9(2):eade2828. doi: 10.1126/sciadv.ade2828. Epub 2023 Jan 13. PubMed |
| Reversibility and developmental neuropathology of linear nevus sebaceous syndrome caused by dysregulation of the RAS pathway. Kim YE, Kim YS, Lee HE, So KH, Choe Y, Suh BC, Kim JH, Park SK, Mathern GW, Gleeson JG, Rah JC, Baek ST. Cell Rep. 2023 Jan 31;42(1):112003. doi: 10.1016/j.celrep.2023.112003. Epub 2023 Jan 14. PubMed |
Genome-scale CRISPR screening in a single mouse liver.
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Cell Genom. 2022 Dec 14;2(12):100217. doi: 10.1016/j.xgen.2022.100217. Epub 2022 Nov 15.
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| Cytochalasin B-Induced Membrane Vesicles from TRAIL-Overexpressing Mesenchymal Stem Cells Induce Extrinsic Pathway of Apoptosis in Breast Cancer Mouse Model. Chulpanova DS, Pukhalskaia TV, Gilazieva ZE, Filina YV, Mansurova MN, Rizvanov AA, Solovyeva VV. Curr Issues Mol Biol. 2023 Jan 9;45(1):571-592. doi: 10.3390/cimb45010038. PubMed |
| RNA mis-splicing drives viral mimicry response after DNMTi therapy in SETD2-mutant kidney cancer. Li HT, Jang HJ, Rohena-Rivera K, Liu M, Gujar H, Kulchycki J, Zhao S, Billet S, Zhou X, Weisenberger DJ, Gill I, Jones PA, Bhowmick NA, Liang G. Cell Rep. 2023 Jan 31;42(1):112016. doi: 10.1016/j.celrep.2023.112016. Epub 2023 Jan 19. PubMed |
Species-specific self-DNA detection mechanisms by mammalian cyclic GMP-AMP synthases.
Mosallanejad K, Kennedy SN, Bahleda KM, Slavik KM, Zhou W, Govande AA, Hancks DC, Kranzusch PJ, Kagan JC.
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| Enhancing adoptive T-cell therapy with fucoidan-based IL-2 delivery microcapsules. Jeon EY, Choi DS, Choi S, Won JY, Jo Y, Kim HB, Jung Y, Shin SC, Min H, Choi HW, Lee MS, Park Y, Chung JJ, Jin HS. Bioeng Transl Med. 2022 Jul 5;8(1):e10362. doi: 10.1002/btm2.10362. eCollection 2023 Jan. PubMed |
| The selective autophagy adaptor p62/SQSTM1 forms phase condensates regulated by HSP27 that facilitate the clearance of damaged lysosomes via lysophagy. Gallagher ER, Holzbaur ELF. Cell Rep. 2023 Feb 28;42(2):112037. doi: 10.1016/j.celrep.2023.112037. Epub 2023 Jan 25. PubMed |
| Neurotransmitter release progressively desynchronizes in induced human neurons during synapse maturation and aging. Uzay B, Houcek A, Ma ZZ, Konradi C, Monteggia LM, Kavalali ET. Cell Rep. 2023 Feb 28;42(2):112042. doi: 10.1016/j.celrep.2023.112042. Epub 2023 Jan 25. PubMed |
| Chromatin complex dependencies reveal targeting opportunities in leukemia. Najm FJ, DeWeirdt P, Moore MM, Bevill SM, El Farran CA, Macias KA, Hegde M, Waterbury AL, Liau BB, van Galen P, Doench JG, Bernstein BE. Nat Commun. 2023 Jan 27;14(1):448. doi: 10.1038/s41467-023-36150-7. PubMed |
| Regulation of beige adipocyte thermogenesis by the cold-repressed ER protein NNAT. Choi KM, Ko CY, An SM, Cho SH, Rowland DJ, Kim JH, Fasoli A, Chaudhari AJ, Bers DM, Yoon JC. Mol Metab. 2023 Mar;69:101679. doi: 10.1016/j.molmet.2023.101679. Epub 2023 Jan 25. PubMed |
| A hierarchical pathway for assembly of the distal appendages that organize primary cilia. Kanie T, Love JF, Fisher SD, Gustavsson AK, Jackson PK. bioRxiv [Preprint]. 2023 Jan 10:2023.01.06.522944. doi: 10.1101/2023.01.06.522944. PubMed |
A dual sgRNA library design to probe genetic modifiers using genome-wide CRISPRi screens.
Guna A, Page KR, Replogle JM, Esantsi TK, Wang ML, Weissman JS, Voorhees RM.
BMC Genomics. 2023 Oct 30;24(1):651. doi: 10.1186/s12864-023-09754-y.
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| Myristoylated Neuronal Calcium Sensor-1 captures the ciliary vesicle at distal appendages. Kanie T, Ng R, Abbott KL, Pongs O, Jackson PK. bioRxiv. 2023 Jan 10:2023.01.06.523037. doi: 10.1101/2023.01.06.523037. Preprint. PubMed |
| Single-chromosome dynamics reveals locus-dependent dynamics and chromosome territory orientation. Chung YC, Bisht M, Thuma J, Tu LC. J Cell Sci. 2023 Feb 15;136(4):jcs260137. doi: 10.1242/jcs.260137. Epub 2023 Feb 27. PubMed |
T-REX17 is a transiently expressed non-coding RNA essential for human endoderm formation.
Landshammer A, Bolondi A, Kretzmer H, Much C, Buschow R, Rose A, Wu HJ, Mackowiak SD, Braendl B, Giesselmann P, Tornisiello R, Parsi KM, Huey J, Mielke T, Meierhofer D, Maehr R, Hnisz D, Michor F, Rinn JL, Meissner A.
Elife. 2023 Jan 31;12:e83077. doi: 10.7554/eLife.83077.
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| Combining single-cell transcriptomics and CellTagging to identify differentiation trajectories of human adipose-derived mesenchymal stem cells. Lin K, Yang Y, Cao Y, Liang J, Qian J, Wang X, Han Q. Stem Cell Res Ther. 2023 Feb 1;14(1):14. doi: 10.1186/s13287-023-03237-3. PubMed |
| Baculovirus displaying SARS-CoV-2 spike RBD promotes neutralizing antibody production in a mouse model. Wahba MA, Mofed D, Ghareeb DA, Omran JI, Salem TZ. J Genet Eng Biotechnol. 2023 Feb 9;21(1):16. doi: 10.1186/s43141-023-00472-2. PubMed |
| Cell cycle-dependent palmitoylation of protocadherin 7 by ZDHHC5 promotes successful cytokinesis. Ozkan NE, Yigit BN, Degirmenci BS, Qureshi MH, Yapici GN, Kamacioglu A, Bavili N, Kiraz A, Ozlu N. J Cell Sci. 2023 Mar 15;136(6):jcs260266. doi: 10.1242/jcs.260266. Epub 2023 Mar 20. PubMed |
| Tet-Regulated Expression and Optical Clearing for In Vivo Visualization of Genetically Encoded Chimeric dCas9/Fluorescent Protein Probes. Maloshenok L, Abushinova G, Kazachkina N, Bogdanov A Jr, Zherdeva V. Materials (Basel). 2023 Jan 19;16(3):940. doi: 10.3390/ma16030940. PubMed |
| NFATc1 marks articular cartilage progenitors and negatively determines articular chondrocyte differentiation. Zhang F, Wang Y, Zhao Y, Wang M, Zhou B, Zhou B, Ge X. Elife. 2023 Feb 15;12:e81569. doi: 10.7554/eLife.81569. PubMed |
| A dual-activity topoisomerase complex promotes both transcriptional activation and repression in response to starvation. Su S, Xue Y, Lee SK, Zhang Y, Fan J, De S, Sharov A, Wang W. Nucleic Acids Res. 2023 Mar 21;51(5):2415-2433. doi: 10.1093/nar/gkad086. PubMed |
| BAG3 regulates the specificity of the recognition of specific MAPT species by NBR1 and SQSTM1. Lin H, Sandkuhler S, Dunlea C, King DH, Johnson GVW. bioRxiv. 2023 Feb 9:2023.02.08.527546. doi: 10.1101/2023.02.08.527546. Preprint. PubMed |
| Exercise-activated hepatic autophagy via the FN1-alpha5beta1 integrin pathway drives metabolic benefits of exercise. Kuramoto K, Liang H, Hong JH, He C. Cell Metab. 2023 Apr 4;35(4):620-632.e5. doi: 10.1016/j.cmet.2023.01.011. Epub 2023 Feb 21. PubMed |
| CRACD loss promotes small cell lung cancer tumorigenesis via EZH2-mediated immune evasion. Zhang S, Kim KB, Huang Y, Kim DW, Kim B, Ko KP, Zou G, Zhang J, Jun S, Kirk NA, Hwang YE, Ban YH, Chan JM, Rudin CM, Park KS, Park JI. bioRxiv [Preprint]. 2023 May 17:2023.02.15.528365. doi: 10.1101/2023.02.15.528365. PubMed |
| Evaluation of CAR-T Cells' Cytotoxicity against Modified Solid Tumor Cell Lines. Valiullina AK, Zmievskaya EA, Ganeeva IA, Zhuravleva MN, Garanina EE, Rizvanov AA, Petukhov AV, Bulatov ER. Biomedicines. 2023 Feb 19;11(2):626. doi: 10.3390/biomedicines11020626. PubMed |
| CAR-T Cells with Phytohemagglutinin (PHA) Provide Anti-Cancer Capacity with Better Proliferation, Rejuvenated Effector Memory, and Reduced Exhausted T Cell Frequencies. Gulden G, Sert B, Teymur T, Ay Y, Tiryaki NN, Mishra AK, Ovali E, Tarhan N, Tastan C. Vaccines (Basel). 2023 Jan 31;11(2):313. doi: 10.3390/vaccines11020313. PubMed |
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| New Approach for Studying of Isoforms and High-Homology Proteins in Mammalian Cells. Soshnikova NV, Simonov YP, Feoktistov AV, Khamidullina AI, Yastrebova MA, Bayramova DO, Tatarskiy VV, Georgieva SG. Int J Mol Sci. 2023 Jul 29;24(15):12153. doi: 10.3390/ijms241512153. PubMed |
| Molecular weight of hyaluronic acid crosslinked into biomaterial scaffolds affects angiogenic potential. Karam J, Singer BJ, Miwa H, Chen LH, Maran K, Hasani M, Garza S, Onyekwere B, Yeh HC, Li S, Carlo DD, Seidlits SK. Acta Biomater. 2023 Oct 1;169:228-242. doi: 10.1016/j.actbio.2023.08.001. Epub 2023 Aug 10. PubMed |
| MSC.sensor: Capturing cancer cell interactions with stroma for functional profiling. Huang Y, Drakul A, Sidhu J, Rauwolf KK, Kim J, Bornhauser B, Bourquin JP. SLAS Discov. 2023 Aug 11:S2472-5552(23)00061-8. doi: 10.1016/j.slasd.2023.08.003. PubMed |
| SOCS3 deletion in effector T cells confers an anti-tumorigenic role of IL-6 to the pro-tumorigenic cytokine. Mise-Omata S, Ando M, Srirat T, Nakagawara K, Hayakawa T, Iizuka-Koga M, Nishimasu H, Nureki O, Ito M, Yoshimura A. Cell Rep. 2023 Aug 29;42(8):112940. doi: 10.1016/j.celrep.2023.112940. Epub 2023 Aug 14. PubMed |
| Discovery of oncogenic ROS1 missense mutations with sensitivity to tyrosine kinase inhibitors. Iyer SR, Nusser K, Jones K, Shinde P, Keddy C, Beach CZ, Aguero E, Force J, Shinde U, Davare MA. EMBO Mol Med. 2023 Oct 11;15(10):e17367. doi: 10.15252/emmm.202217367. Epub 2023 Aug 17. PubMed |
| Pyruvate anaplerosis is a targetable vulnerability in persistent leukaemic stem cells. Rattigan KM, Brabcova Z, Sarnello D, Zarou MM, Roy K, Kwan R, de Beauchamp L, Dawson A, Ianniciello A, Khalaf A, Kalkman ER, Scott MT, Dunn K, Sumpton D, Michie AM, Copland M, Tardito S, Gottlieb E, Vignir Helgason G. Nat Commun. 2023 Aug 17;14(1):4634. doi: 10.1038/s41467-023-40222-z. PubMed |
An idiosyncratic zonated stroma encapsulates desmoplastic liver metastases and originates from injured liver.
Fernandez Moro C, Geyer N, Harrizi S, Hamidi Y, Soderqvist S, Kuznyecov D, Tidholm Qvist E, Salmonson Schaad M, Hermann L, Lindberg A, Heuchel RL, Martin-Bernabe A, Dhanjal S, Navis AC, Villard C, Del Valle AC, Bozoky L, Sparrelid E, Dirix L, Strell C, Ostman A, Schmierer B, Vermeulen PB, Engstrand J, Bozoky B, Gerling M.
Nat Commun. 2023 Aug 18;14(1):5024. doi: 10.1038/s41467-023-40688-x.
PubMed
Associated Plasmids |
| IL-2 can signal via chemokine receptors to promote regulatory T cells' suppressive function. Sun H, Lee HS, Kim SH, Fernandes de Lima M, Gingras AR, Du Q, McLaughlin W, Ablack J, Lopez-Ramirez MA, Lagarrigue F, Fan Z, Chang JT, VanDyke D, Spangler JB, Ginsberg MH. Cell Rep. 2023 Aug 29;42(8):112996. doi: 10.1016/j.celrep.2023.112996. Epub 2023 Aug 21. PubMed |
| The IFT81-IFT74 complex acts as an unconventional RabL2 GTPase-activating protein during intraflagellar transport. Boegholm N, Petriman NA, Loureiro-Lopez M, Wang J, Vela MIS, Liu B, Kanie T, Ng R, Jackson PK, Andersen JS, Lorentzen E. EMBO J. 2023 Sep 18;42(18):e111807. doi: 10.15252/embj.2022111807. Epub 2023 Aug 22. PubMed |
| Convergent activation of two-pore channels mediated by the NAADP-binding proteins JPT2 and LSM12. Gunaratne GS, Brailoiu E, Kumar S, Yuan Y, Slama JT, Walseth TF, Patel S, Marchant JS. Sci Signal. 2023 Aug 22;16(799):eadg0485. doi: 10.1126/scisignal.adg0485. Epub 2023 Aug 22. PubMed |
| MARCH7-mediated ubiquitination decreases the solubility of ATG14 to inhibit autophagy. Shi X, Wu W, Feng Z, Fan P, Shi R, Zhang X. Cell Rep. 2023 Sep 26;42(9):113045. doi: 10.1016/j.celrep.2023.113045. Epub 2023 Aug 26. PubMed |
| SMC3 epigenetic silencing regulates Rab27a expression and drives pancreatic cancer progression. Bastos N, Castaldo SA, Adem B, Machado JC, Melo CA, Melo SA. J Transl Med. 2023 Aug 28;21(1):578. doi: 10.1186/s12967-023-04448-1. PubMed |
| Host-derived growth factors drive ERK phosphorylation and MCL1 expression to promote osteosarcoma cell survival during metastatic lung colonization. McAloney CA, Makkawi R, Budhathoki Y, Cannon MV, Franz EM, Gross AC, Cam M, Vetter TA, Duhen R, Davies AE, Roberts RD. Cell Oncol (Dordr). 2024 Feb;47(1):259-282. doi: 10.1007/s13402-023-00867-w. Epub 2023 Sep 7. PubMed |
| Usp25-Erlin1/2 activity limits cholesterol flux to restrict virus infection. Teo QW, Wong HH, Heunis T, Stancheva V, Hachim A, Lv H, Siu L, Ho J, Lan Y, Mok CKP, Ulferts R, Sanyal S. Dev Cell. 2023 Nov 20;58(22):2495-2509.e6. doi: 10.1016/j.devcel.2023.08.013. Epub 2023 Sep 7. PubMed |
| SETD2 Deficiency Confers Sensitivity to Dual Inhibition of DNA Methylation and PARP in Kidney Cancer. Zhou X, Sekino Y, Li HT, Fu G, Yang Z, Zhao S, Gujar H, Zu X, Weisenberger DJ, Gill IS, Tulpule V, D'souza A, Quinn DI, Han B, Liang G. Cancer Res. 2023 Nov 15;83(22):3813-3826. doi: 10.1158/0008-5472.CAN-23-0401. PubMed |
| Neuronal activation of G(alphaq) EGL-30/GNAQ late in life rejuvenates cognition across species. Stevenson ME, Bieri G, Kaletsky R, St Ange J, Remesal L, Pratt KJB, Zhou S, Weng Y, Murphy CT, Villeda SA. Cell Rep. 2023 Sep 26;42(9):113151. doi: 10.1016/j.celrep.2023.113151. Epub 2023 Sep 19. PubMed |
| DUX4-r exerts a neomorphic activity that depends on GTF2I in acute lymphoblastic leukemia. Campolungo D, Salome M, Biferali B, Tascini AS, Gabellini D. Sci Adv. 2023 Sep 15;9(37):eadi3771. doi: 10.1126/sciadv.adi3771. Epub 2023 Sep 15. PubMed |
| Atypical peripheral actin band formation via overactivation of RhoA and nonmuscle myosin II in mitofusin 2-deficient cells. Wang Y, Troughton LD, Xu F, Chatterjee A, Ding C, Zhao H, Cifuentes LP, Wagner RB, Wang T, Tan S, Chen J, Li L, Umulis D, Kuang S, Suter DM, Yuan C, Chan D, Huang F, Oakes PW, Deng Q. Elife. 2023 Sep 19;12:e88828. doi: 10.7554/eLife.88828. PubMed |
| Role of the Senescence-Associated Factor Dipeptidyl Peptidase 4 in the Pathogenesis of SARS-CoV-2 Infection. Deinhardt-Emmer S, Deshpande S, Kitazawa K, Herman AB, Bons J, Rose JP, Kumar PA, Anerillas C, Neri F, Ciotlos S, Perez K, Kose-Vogel N, Hader A, Abdelmohsen K, Loffler B, Gorospe M, Desprez PY, Melov S, Furman D, Schilling B, Campisi J. Aging Dis. 2024 May 7;15(3):1398-1415. doi: 10.14336/AD.2023.0812. PubMed |
| Generation of mouse models carrying B cell restricted single or multiplexed loss-of-function mutations through CRISPR-Cas9 gene editing. Ten Hacken E, Gruber M, Hernandez-Sanchez M, Hoffmann GB, Baranowski K, Redd RA, Clement K, Livak K, Wu CJ. STAR Protoc. 2023 Dec 15;4(4):102165. doi: 10.1016/j.xpro.2023.102165. Epub 2023 Sep 18. PubMed |
| Pyruvate Kinase Activity Regulates Cystine Starvation Induced Ferroptosis through Malic Enzyme 1 in Pancreatic Cancer Cells. Ensink E, Jordan T, Medeiros HCD, Thurston G, Pardal A, Yu L, Lunt SY. bioRxiv [Preprint]. 2023 Sep 17:2023.09.15.557984. doi: 10.1101/2023.09.15.557984. PubMed |
| Wearable Biosensor with Molecularly Imprinted Conductive Polymer Structure to Detect Lentivirus in Aerosol. Batra JS, Chi TY, Huang MF, Zhu D, Chen Z, Lee DF, Kameoka J. Biosensors (Basel). 2023 Aug 31;13(9):861. doi: 10.3390/bios13090861. PubMed |
| Mitigation of chromosome loss in clinical CRISPR-Cas9-engineered T cells. Tsuchida CA, Brandes N, Bueno R, Trinidad M, Mazumder T, Yu B, Hwang B, Chang C, Liu J, Sun Y, Hopkins CR, Parker KR, Qi Y, Hofman L, Satpathy AT, Stadtmauer EA, Cate JHD, Eyquem J, Fraietta JA, June CH, Chang HY, Ye CJ, Doudna JA. Cell. 2023 Oct 12;186(21):4567-4582.e20. doi: 10.1016/j.cell.2023.08.041. Epub 2023 Oct 3. PubMed |
| GNAQ/GNA11 Mosaicism Causes Aberrant Calcium Signaling Susceptible to Targeted Therapeutics. Zecchin D, Knopfel N, Gluck AK, Stevenson M, Sauvadet A, Polubothu S, Barberan-Martin S, Michailidis F, Bryant D, Inoue A, Lines KE, Hannan FM, Semple RK, Thakker RV, Kinsler VA. J Invest Dermatol. 2024 Apr;144(4):811-819.e4. doi: 10.1016/j.jid.2023.08.028. Epub 2023 Oct 4. PubMed |
| Electroporation-based Easi-CRISPR yields biallelic insertions of EGFP-HiBiT cassette in immortalized chicken oviduct epithelial cells. Liu L, Wei J, Chen C, Liang Q, Wang B, Wu W, Li G, Zheng X. Poult Sci. 2023 Dec;102(12):103112. doi: 10.1016/j.psj.2023.103112. Epub 2023 Sep 14. PubMed |
| Cardiac glycoside ouabain efficiently targets leukemic stem cell apoptotic machinery independent of cell differentiation status. Poohadsuan J, O'Doherty GA, Owattanapanich W, Kungwankiattichai S, Rojanasakul Y, Issaragrisil S, Luanpitpong S. Cell Commun Signal. 2023 Oct 12;21(1):283. doi: 10.1186/s12964-023-01317-8. PubMed |
| DNA damage induces nuclear envelope rupture through ATR-mediated phosphorylation of lamin A/C. Kovacs MT, Vallette M, Wiertsema P, Dingli F, Loew D, Nader GPF, Piel M, Ceccaldi R. Mol Cell. 2023 Oct 19;83(20):3659-3668.e10. doi: 10.1016/j.molcel.2023.09.023. Epub 2023 Oct 12. PubMed |
| CD36 maintains lipid homeostasis via selective uptake of monounsaturated fatty acids during matrix detachment and tumor progression. Terry AR, Nogueira V, Rho H, Ramakrishnan G, Li J, Kang S, Pathmasiri KC, Bhat SA, Jiang L, Kuchay S, Cologna SM, Hay N. Cell Metab. 2023 Nov 7;35(11):2060-2076.e9. doi: 10.1016/j.cmet.2023.09.012. Epub 2023 Oct 17. PubMed |
Sequential activation of E2F via Rb degradation and c-Myc drives resistance to CDK4/6 inhibitors in breast cancer.
Kim S, Armand J, Safonov A, Zhang M, Soni RK, Schwartz G, McGuinness JE, Hibshoosh H, Razavi P, Kim M, Chandarlapaty S, Yang HW.
Cell Rep. 2023 Nov 28;42(11):113198. doi: 10.1016/j.celrep.2023.113198. Epub 2023 Oct 21.
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| Interplay between the plasma membrane and cell-cell adhesion maintains epithelial identity for correct polarised cell divisions. Hosawi MM, Cheng J, Fankhaenel M, Przewloka MR, Elias S. J Cell Sci. 2024 Mar 1;137(5):jcs261701. doi: 10.1242/jcs.261701. Epub 2023 Nov 28. PubMed |
| Stable Isotope-Assisted Untargeted Metabolomics Identifies ALDH1A1-Driven Erythronate Accumulation in Lung Cancer Cells. Zhang J, Keibler MA, Dong W, Ghelfi J, Cordes T, Kanashova T, Pailot A, Linster CL, Dittmar G, Metallo CM, Lautenschlaeger T, Hiller K, Stephanopoulos G. Biomedicines. 2023 Oct 19;11(10):2842. doi: 10.3390/biomedicines11102842. PubMed |
| Activation of Chaperone-Mediated Autophagy Inhibits the Aryl Hydrocarbon Receptor Function by Degrading This Receptor in Human Lung Epithelial Carcinoma A549 Cells. Xiong R, Shao D, Do S, Chan WK. Int J Mol Sci. 2023 Oct 12;24(20):15116. doi: 10.3390/ijms242015116. PubMed |
| LKB1 suppresses growth and promotes the internalization of EGFR through the PIKFYVE lipid kinase. Ferrarone JR, Thomas J, Unni AM, Zheng Y, Nagiec MJ, Gardner EE, Mashadova O, Li K, Koundouros N, Montalbano A, Mustafa M, Cantley LC, Blenis J, Sanjana NE, Varmus H. bioRxiv [Preprint]. 2023 Oct 20:2023.10.19.563158. doi: 10.1101/2023.10.19.563158. PubMed |
| Dicer deficiency in microglia leads to accelerated demyelination and failed remyelination. Tripathi A, Rai N, Perles A, Jones C, Dutta R. bioRxiv [Preprint]. 2023 Oct 19:2023.10.17.562812. doi: 10.1101/2023.10.17.562812. PubMed |
| Chimeric autoantibody receptor T cells deplete NMDA receptor-specific B cells. Reincke SM, von Wardenburg N, Homeyer MA, Kornau HC, Spagni G, Li LY, Kreye J, Sanchez-Sendin E, Blumenau S, Stappert D, Radbruch H, Hauser AE, Kunkele A, Edes I, Schmitz D, Pruss H. Cell. 2023 Nov 9;186(23):5084-5097.e18. doi: 10.1016/j.cell.2023.10.001. Epub 2023 Nov 1. PubMed |
| CRISPR/Cas9 screens unravel miR-3689a-3p regulating sorafenib resistance in hepatocellular carcinoma via suppressing CCS/SOD1-dependent mitochondrial oxidative stress. Lu Y, Chan YT, Wu J, Feng Z, Yuan H, Li Q, Xing T, Xu L, Zhang C, Tan HY, Lee TK, Feng Y, Wang N. Drug Resist Updat. 2023 Nov;71:101015. doi: 10.1016/j.drup.2023.101015. Epub 2023 Oct 29. PubMed |
Gasdermin D permeabilization of mitochondrial inner and outer membranes accelerates and enhances pyroptosis.
Miao R, Jiang C, Chang WY, Zhang H, An J, Ho F, Chen P, Zhang H, Junqueira C, Amgalan D, Liang FG, Zhang J, Evavold CL, Hafner-Bratkovic I, Zhang Z, Fontana P, Xia S, Waldeck-Weiermair M, Pan Y, Michel T, Bar-Peled L, Wu H, Kagan JC, Kitsis RN, Zhang P, Liu X, Lieberman J.
Immunity. 2023 Nov 14;56(11):2523-2541.e8. doi: 10.1016/j.immuni.2023.10.004. Epub 2023 Nov 3.
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Associated Plasmids |
| The RNA helicase DDX39A binds a conserved structure in chikungunya virus RNA to control infection. Tapescu I, Taschuk F, Pokharel SM, Zginnyk O, Ferretti M, Bailer PF, Whig K, Madden EA, Heise MT, Schultz DC, Cherry S. Mol Cell. 2023 Nov 16;83(22):4174-4189.e7. doi: 10.1016/j.molcel.2023.10.008. Epub 2023 Nov 9. PubMed |
| A combinatorial therapeutic approach to enhance FLT3-ITD AML treatment. Long J, Chen X, Shen Y, Lei Y, Mu L, Wang Z, Xiang R, Gao W, Wang L, Wang L, Jiang J, Zhang W, Lu H, Dong Y, Ding Y, Zhu H, Hong D, Sun YE, Hu J, Liang A. Cell Rep Med. 2023 Nov 21;4(11):101286. doi: 10.1016/j.xcrm.2023.101286. Epub 2023 Nov 10. PubMed |
| Differences in syncytia formation by SARS-CoV-2 variants modify host chromatin accessibility and cellular senescence via TP53. Lee JD, Menasche BL, Mavrikaki M, Uyemura MM, Hong SM, Kozlova N, Wei J, Alfajaro MM, Filler RB, Muller A, Saxena T, Posey RR, Cheung P, Muranen T, Heng YJ, Paulo JA, Wilen CB, Slack FJ. Cell Rep. 2023 Dec 26;42(12):113478. doi: 10.1016/j.celrep.2023.113478. Epub 2023 Nov 21. PubMed |
| Anti-TIM3 chimeric antigen receptor-natural killer cells from engineered induced pluripotent stem cells effectively target acute myeloid leukemia cells. Klaihmon P, Luanpitpong S, Kang X, Issaragrisil S. Cancer Cell Int. 2023 Nov 27;23(1):297. doi: 10.1186/s12935-023-03153-9. PubMed |
| Aryl hydrocarbon receptor is a tumor promoter in MYCN-amplified neuroblastoma cells through suppression of differentiation. Chaudhry KA, Jacobi JJ, Gillard BM, Karasik E, Martin JC, da Silva Fernandes T, Hurley E, Feltri ML, Attwood KM, Twist CJ, Smiraglia DJ, Long MD, Bianchi-Smiraglia A. iScience. 2023 Oct 21;26(11):108303. doi: 10.1016/j.isci.2023.108303. eCollection 2023 Nov 17. PubMed |
The MHC-E peptide ligands for checkpoint CD94/NKG2A are governed by inflammatory signals, whereas LILRB1/2 receptors are peptide indifferent.
Middelburg J, Ghaffari S, Schoufour TAW, Sluijter M, Schaap G, Goynuk B, Sala BM, Al-Tamimi L, Scheeren F, Franken KLMC, Akkermans JJLL, Cabukusta B, Joosten SA, Derksen I, Neefjes J, van der Burg SH, Achour A, Wijdeven RHM, Weidanz J, van Hall T.
Cell Rep. 2023 Dec 26;42(12):113516. doi: 10.1016/j.celrep.2023.113516. Epub 2023 Dec 3.
PubMed
Associated Plasmids |
| Rational optimization of a transcription factor activation domain inhibitor. Basu S, Martinez-Cristobal P, Frigole-Vivas M, Pesarrodona M, Lewis M, Szulc E, Banuelos CA, Sanchez-Zarzalejo C, Bielskute S, Zhu J, Pombo-Garcia K, Garcia-Cabau C, Zodi L, Dockx H, Smak J, Kaur H, Batlle C, Mateos B, Biesaga M, Escobedo A, Bardia L, Verdaguer X, Ruffoni A, Mawji NR, Wang J, Obst JK, Tam T, Brun-Heath I, Ventura S, Meierhofer D, Garcia J, Robustelli P, Stracker TH, Sadar MD, Riera A, Hnisz D, Salvatella X. Nat Struct Mol Biol. 2023 Dec;30(12):1958-1969. doi: 10.1038/s41594-023-01159-5. Epub 2023 Dec 4. PubMed |
| Budget-Friendly Generation, Biochemical Analyses, and Lentiviral Transduction of Patient-Derived Colon Organoids. Rigaux E, Chen JW, George F, Lemaire J, Bertrand C, Faugeras L, Fattaccioli A, Gilliaux Q, D'Hondt L, Michiels C, Renard HF, Zanin N. Curr Protoc. 2023 Dec;3(12):e943. doi: 10.1002/cpz1.943. PubMed |
| Profiling nuclear cysteine ligandability and effects on nuclear localization using proximity labeling-coupled chemoproteomics. Peng Q, Weerapana E. Cell Chem Biol. 2024 Mar 21;31(3):550-564.e9. doi: 10.1016/j.chembiol.2023.11.010. Epub 2023 Dec 11. PubMed |
| An ERK5-PFKFB3 axis regulates glycolysis and represents a therapeutic vulnerability in pediatric diffuse midline glioma. Casillo SM, Gatesman TA, Chilukuri A, Varadharajan S, Johnson BJ, David Premkumar DR, Jane EP, Plute TJ, Koncar RF, Stanton AJ, Biagi-Junior CAO, Barber CS, Halbert ME, Golbourn BJ, Halligan K, Cruz AF, Mansi NM, Cheney A, Mullett SJ, Land CV, Perez JL, Myers MI, Agrawal N, Michel JJ, Chang YF, Vaske OM, MichaelRaj A, Lieberman FS, Felker J, Shiva S, Bertrand KC, Amankulor N, Hadjipanayis CG, Abdullah KG, Zinn PO, Friedlander RM, Abel TJ, Nazarian J, Venneti S, Filbin MG, Gelhaus SL, Mack SC, Pollack IF, Agnihotri S. Cell Rep. 2024 Jan 23;43(1):113557. doi: 10.1016/j.celrep.2023.113557. Epub 2023 Dec 18. PubMed |
| Non-canonical Hedgehog signaling mediates profibrotic hematopoiesis-stroma crosstalk in myeloproliferative neoplasms. Pritchard JE, Pearce JE, Snoeren IAM, Fuchs SNR, Gotz K, Peisker F, Wagner S, Benabid A, Lutterbach N, Kloker V, Nagai JS, Hannani MT, Galyga AK, Sistemich E, Banjanin B, Flosdorf N, Bindels E, Olschok K, Biaesch K, Chatain N, Bhagwat N, Dunbar A, Sarkis R, Naveiras O, Berres ML, Koschmieder S, Levine RL, Costa IG, Gleitz HFE, Kramann R, Schneider RK. Cell Rep. 2024 Jan 23;43(1):113608. doi: 10.1016/j.celrep.2023.113608. Epub 2023 Dec 20. PubMed |
| Distinctive In Vitro Phenotypes in iPSC-Derived Neurons From Patients With Gain- and Loss-of-Function SCN2A Developmental and Epileptic Encephalopathy. Mao M, Mattei C, Rollo B, Byars S, Cuddy C, Berecki G, Heighway J, Pachernegg S, Menheniott T, Apted D, Jia L, Dalby K, Nemiroff A, Mullen S, Reid CA, Maljevic S, Petrou S. J Neurosci. 2024 Feb 21;44(8):e0692232023. doi: 10.1523/JNEUROSCI.0692-23.2023. PubMed |
| Characterization of dabrafenib-induced drug insensitivity via cellular barcoding and collateral sensitivity to second-line therapeutics. Baygin RC, Yilmaz KC, Acar A. Sci Rep. 2024 Jan 2;14(1):286. doi: 10.1038/s41598-023-50443-3. PubMed |
| Integrated multi-omics analyses identify anti-viral host factors and pathways controlling SARS-CoV-2 infection. Hou J, Wei Y, Zou J, Jaffery R, Sun L, Liang S, Zheng N, Guerrero AM, Egan NA, Bohat R, Chen S, Zheng C, Mao X, Yi SS, Chen K, McGrail DJ, Sahni N, Shi PY, Chen Y, Xie X, Peng W. Nat Commun. 2024 Jan 2;15(1):109. doi: 10.1038/s41467-023-44175-1. PubMed |
An adenine base editor variant expands context compatibility.
Xiao YL, Wu Y, Tang W.
Nat Biotechnol. 2024 Jan 2. doi: 10.1038/s41587-023-01994-3.
PubMed
Associated Plasmids |
| KDM5B predicts temozolomide-resistant subclones in glioblastoma. Ullrich V, Ertmer S, Baginska A, Dorsch M, Gull HH, Cima I, Berger P, Dobersalske C, Langer S, Meyer L, Dujardin P, Kebir S, Glas M, Blau T, Keyvani K, Rauschenbach L, Sure U, Roesch A, Gruner BM, Scheffler B. iScience. 2023 Dec 3;27(1):108596. doi: 10.1016/j.isci.2023.108596. eCollection 2024 Jan 19. PubMed |
| Disease-associated polyalanine expansion mutations impair UBA6-dependent ubiquitination. Amer-Sarsour F, Falik D, Berdichevsky Y, Kordonsky A, Eid S, Rabinski T, Ishtayeh H, Cohen-Adiv S, Braverman I, Blumen SC, Laviv T, Prag G, Vatine GD, Ashkenazi A. EMBO J. 2024 Jan;43(2):250-276. doi: 10.1038/s44318-023-00018-9. Epub 2024 Jan 2. PubMed |
| Kaposi's sarcoma herpesvirus exploits the DNA damage response to circularize its genome. Li S, Liu B, Tan M, Juillard F, Szymula A, Alvarez AL, Van Sciver N, George A, Ramachandran A, Raina K, Tumuluri VS, Costa CN, Simas JP, Kaye KM. Nucleic Acids Res. 2024 Feb 28;52(4):1814-1829. doi: 10.1093/nar/gkad1224. PubMed |
| DMT1-dependent endosome-mitochondria interactions regulate mitochondrial iron translocation and metastatic outgrowth. Barra J, Crosbourne I, Roberge CL, Bossardi-Ramos R, Warren JSA, Matteson K, Wang L, Jourd'heuil F, Borisov SM, Bresnahan E, Bravo-Cordero JJ, Dmitriev RI, Jourd'heuil D, Adam AP, Lamar JM, Corr DT, Barroso MM. Oncogene. 2024 Feb;43(9):650-667. doi: 10.1038/s41388-023-02933-x. Epub 2024 Jan 6. PubMed |
| Mitofusin 1 silencing decreases the senescent associated secretory phenotype, promotes immune cell recruitment and delays melanoma tumor growth after chemotherapy. Tarallo D, Martinez J, Leyva A, Monaco A, Perroni C, Tassano M, Gambini JP, Cappetta M, Duran R, Moreno M, Quijano C. Sci Rep. 2024 Jan 9;14(1):909. doi: 10.1038/s41598-024-51427-7. PubMed |
MRE11 liberates cGAS from nucleosome sequestration during tumorigenesis.
Cho MG, Kumar RJ, Lin CC, Boyer JA, Shahir JA, Fagan-Solis K, Simpson DA, Fan C, Foster CE, Goddard AM, Lerner LM, Ellington SW, Wang Q, Wang Y, Ho AY, Liu P, Perou CM, Zhang Q, McGinty RK, Purvis JE, Gupta GP.
Nature. 2024 Jan 10. doi: 10.1038/s41586-023-06889-6.
PubMed
Associated Plasmids |
| Nuclear Phosphoproteome Reveals Prolyl Isomerase PIN1 as a Modulator of Oncogene-Induced Senescence. Mohallem R, Aryal UK. Mol Cell Proteomics. 2024 Feb;23(2):100715. doi: 10.1016/j.mcpro.2024.100715. Epub 2024 Jan 10. PubMed |
| The membrane-associated ubiquitin ligase MARCHF8 stabilizes the human papillomavirus oncoprotein E7 by degrading CUL1 and UBE2L3 in head and neck cancer. Khalil MI, Yang C, Vu L, Chadha S, Nabors H, James CD, Morgan IM, Pyeon D. J Virol. 2024 Feb 20;98(2):e0172623. doi: 10.1128/jvi.01726-23. Epub 2024 Jan 16. PubMed |
| Hydroxynorketamine, but not ketamine, acts via alpha7 nicotinic acetylcholine receptor to control presynaptic function and gene expression. Guhathakurta D, Petruskova A, Akdas EY, Perello-Amoros B, Frischknecht R, Anni D, Weiss EM, Walter M, Fejtova A. Transl Psychiatry. 2024 Jan 22;14(1):47. doi: 10.1038/s41398-024-02744-y. PubMed |
| PD-1 signaling uncovers a pathogenic subset of T cells in inflammatory arthritis. Straube J, Bukhari S, Lerrer S, Winchester RJ, Gartshteyn Y, Henick BS, Dragovich MA, Mor A. Arthritis Res Ther. 2024 Jan 22;26(1):32. doi: 10.1186/s13075-023-03259-5. PubMed |
| Charting Single Cell Lineage Dynamics and Mutation Networks via Homing CRISPR. Wang L, Dong W, Yin Z, Sheng J, Ezeana CF, Yang L, Yu X, Wong SS, Wan Z, Danforth RL, Han K, Gao D, Wong STC. bioRxiv [Preprint]. 2024 Jan 7:2024.01.05.574236. doi: 10.1101/2024.01.05.574236. PubMed |
| Germinal Center Cytokines Driven Epigenetic Control of Epstein-Barr Virus Latency Gene Expression. Yifei L, Jinjie Y, Beri NR, Roth LG, Ethel C, Benjamin E G. bioRxiv [Preprint]. 2024 Jan 3:2024.01.02.573986. doi: 10.1101/2024.01.02.573986. PubMed |
| D-type cyclins regulate DNA mismatch repair in the G1 and S phases of the cell cycle, maintaining genome stability. Rona G, Miwatani-Minter B, Zhang Q, Goldberg HV, Kerzhnerman MA, Howard JB, Simoneschi D, Lane E, Hobbs JW, Sassani E, Wang AA, Keegan S, Laverty DJ, Piett CG, Pongor LS, Xu ML, Andrade J, Thomas A, Sicinski P, Askenazi M, Ueberheide B, Fenyo D, Nagel ZD, Pagano M. bioRxiv [Preprint]. 2024 Jan 13:2024.01.12.575420. doi: 10.1101/2024.01.12.575420. PubMed |
| Cholinergic signaling via muscarinic M1 receptor confers resistance to docetaxel in prostate cancer. Wang J, Wei J, Pu T, Zeng A, Karthikeyan V, Bechtold B, Vo K, Chen J, Lin TP, Chang AP, Corey E, Puhr M, Klocker H, Culig Z, Bland T, Wu BJ. Cell Rep Med. 2024 Feb 20;5(2):101388. doi: 10.1016/j.xcrm.2023.101388. Epub 2024 Jan 22. PubMed |
| Massively parallel disruption of enhancers active in human neural stem cells. Geller E, Noble MA, Morales M, Gockley J, Emera D, Uebbing S, Cotney JL, Noonan JP. Cell Rep. 2024 Feb 27;43(2):113693. doi: 10.1016/j.celrep.2024.113693. Epub 2024 Jan 23. PubMed |
| Involvement of Protease-Activated Receptor2 Pleckstrin Homology Binding Domain in Ovarian Cancer: Expression in Fallopian Tubes and Drug Design. Nag JK, Grisaru-Granovsky S, Armon S, Rudina T, Appasamy P, Bar-Shavit R. Biomedicines. 2024 Jan 22;12(1):246. doi: 10.3390/biomedicines12010246. PubMed |
| Nonsynonymous Mutations in Intellectual Disability and Autism Spectrum Disorder Gene PTCHD1 Disrupt N-Glycosylation and Reduce Protein Stability. Xie CTY, Pastore SF, Vincent JB, Frankland PW, Hamel PA. Cells. 2024 Jan 21;13(2):199. doi: 10.3390/cells13020199. PubMed |
Calcium transients trigger switch-like discharge of prostaglandin E(2) in an extracellular signal-regulated kinase-dependent manner.
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| The helicase domain of human Dicer prevents RNAi-independent activation of antiviral and inflammatory pathways. Baldaccini M, Gaucherand L, Chane-Woon-Ming B, Messmer M, Gucciardi F, Pfeffer S. EMBO J. 2024 Mar;43(5):806-835. doi: 10.1038/s44318-024-00035-2. Epub 2024 Jan 29. PubMed |
| SARS-CoV-2 and oncolytic EV-D68-encoded proteases differentially regulate pyroptosis. Shen S, Guo H, Li Y, Zhang L, Tang Y, Li H, Li X, Wang P-H, Yu X-F, Wei W. J Virol. 2024 Feb 20;98(2):e0190923. doi: 10.1128/jvi.01909-23. Epub 2024 Jan 30. PubMed |
| K-Ras(V12) differentially affects the three Akt isoforms in lung and pancreatic carcinoma cells and upregulates E-cadherin and NCAM via Akt3. Geissert R, Lammert A, Wirth S, Honig R, Lohfink D, Unger M, Pek D, Schluter K, Scheftschik T, Smit DJ, Jucker M, Menke A, Giehl K. Cell Commun Signal. 2024 Jan 30;22(1):85. doi: 10.1186/s12964-024-01484-2. PubMed |
| Gene engineered exosome reverses T cell exhaustion in cancer immunotherapy. Li P, Xie Y, Wang J, Bao C, Duan J, Liu Y, Luo Q, Xu J, Ren Y, Jiang M, Li J, Guo H, Zhao H, Wang G, Liang Y, Lu W. Bioact Mater. 2024 Jan 13;34:466-481. doi: 10.1016/j.bioactmat.2024.01.008. eCollection 2024 Apr. PubMed |
| CAG repeat expansions create splicing acceptor sites and produce aberrant repeat-containing RNAs. Anderson R, Das MR, Chang Y, Farenhem K, Schmitz CO, Jain A. Mol Cell. 2024 Feb 15;84(4):702-714.e10. doi: 10.1016/j.molcel.2024.01.006. Epub 2024 Jan 30. PubMed |
| PNMA2 forms immunogenic non-enveloped virus-like capsids associated with paraneoplastic neurological syndrome. Xu J, Erlendsson S, Singh M, Holling GA, Regier M, Ibiricu I, Einstein J, Hantak MP, Day GS, Piquet AL, Smith TL, Clardy SL, Whiteley AM, Feschotte C, Briggs JAG, Shepherd JD. Cell. 2024 Feb 15;187(4):831-845.e19. doi: 10.1016/j.cell.2024.01.009. Epub 2024 Jan 31. PubMed |
| One-pot DTECT enables rapid and efficient capture of genetic signatures for precision genome editing and clinical diagnostics. Baudrier L, Benamozig O, Langley J, Chopra S, Kalashnikova T, Benaoudia S, Singh G, Mahoney DJ, Wright NAM, Billon P. Cell Rep Methods. 2024 Feb 26;4(2):100698. doi: 10.1016/j.crmeth.2024.100698. Epub 2024 Jan 31. PubMed |
| The neuronal transcription factor MEIS2 is a calpain-2 protease target. Muller T, Reichlmeir M, Hau AC, Wittig I, Schulte D. J Cell Sci. 2024 Feb 15;137(4):jcs261482. doi: 10.1242/jcs.261482. Epub 2024 Feb 28. PubMed |
| Micronucleus is not a potent inducer of the cGAS/STING pathway. Sato Y, Hayashi MT. Life Sci Alliance. 2024 Feb 2;7(4):e202302424. doi: 10.26508/lsa.202302424. Print 2024 Apr. PubMed |
| Extracellular Proximity Labeling Reveals an Expanded Interactome for the Matrisome Protein TIMP2. Peeney D, Gurung S, Rich JA, Coates-Park S, Liu Y, Toor J, Jones J, Richie CT, Jenkins LM, Stetler-Stevenson WG. Res Sq [Preprint]. 2024 Jan 15:rs.3.rs-3857263. doi: 10.21203/rs.3.rs-3857263/v1. PubMed |
| Effect of Octamer-Binding Transcription Factor 4 Overexpression on the Neural Induction of Human Dental Pulp Stem Cells. Gancheva MR, Kremer K, Breen J, Arthur A, Hamilton-Bruce A, Thomas P, Gronthos S, Koblar S. Stem Cell Rev Rep. 2024 Apr;20(3):797-815. doi: 10.1007/s12015-024-10678-7. Epub 2024 Feb 5. PubMed |
| Direct reprogramming of non-limb fibroblasts to cells with properties of limb progenitors. Atsuta Y, Lee C, Rodrigues AR, Colle C, Tomizawa RR, Lujan EG, Tschopp P, Galan L, Zhu M, Gorham JM, Vannier JP, Seidman CE, Seidman JG, Ros MA, Pourquie O, Tabin CJ. Dev Cell. 2024 Feb 5;59(3):415-430.e8. doi: 10.1016/j.devcel.2023.12.010. PubMed |
| USP54 is a potential therapeutic target in castration-resistant prostate cancer. Zhou C, Zhang X, Ma H, Zhou Y, Meng Y, Chen C, Shi G, Yu W, Zhang J. BMC Urol. 2024 Feb 6;24(1):32. doi: 10.1186/s12894-024-01418-7. PubMed |
| Antibody surface mobility amplifies FcgammaR signaling via Arp2/3 during phagocytosis. Jo S, Fischer BR, Cronin NM, Nurmalasari NPD, Loyd YM, Kerkvliet JG, Bailey EM, Anderson RB, Scott BL, Hoppe AD. Biophys J. 2024 Aug 6;123(15):2312-2327. doi: 10.1016/j.bpj.2024.01.036. Epub 2024 Feb 5. PubMed |
Three-step docking by WIPI2, ATG16L1, and ATG3 delivers LC3 to the phagophore.
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| IMPDH2 filaments protect from neurodegeneration in AMPD2 deficiency. Flores-Mendez M, Ohl L, Roule T, Zhou Y, Tintos-Hernandez JA, Walsh K, Ortiz-Gonzalez XR, Akizu N. bioRxiv [Preprint]. 2024 Jan 22:2024.01.20.576443. doi: 10.1101/2024.01.20.576443. PubMed |
| Pharmacological inhibition of neddylation impairs long interspersed element 1 retrotransposition. Li Y, Shen S, Guo H, Li H, Zhang L, Zhang B, Yu XF, Wei W. Cell Rep. 2024 Feb 27;43(2):113749. doi: 10.1016/j.celrep.2024.113749. Epub 2024 Feb 7. PubMed |
| Protocol for organelle-specific cysteine capture and quantification of cysteine oxidation state. Julio AR, Yan T, Backus KM. STAR Protoc. 2024 Mar 15;5(1):102865. doi: 10.1016/j.xpro.2024.102865. Epub 2024 Feb 6. PubMed |
| Integrative high-throughput enhancer surveying and functional verification divulges a YY2-condensed regulatory axis conferring risk for osteoporosis. Chen XF, Duan YY, Jia YY, Dong QH, Shi W, Zhang Y, Dong SS, Li M, Liu Z, Chen F, Huang XT, Hao RH, Zhu DL, Jing RH, Guo Y, Yang TL. Cell Genom. 2024 Mar 13;4(3):100501. doi: 10.1016/j.xgen.2024.100501. Epub 2024 Feb 8. PubMed |
| Mitochondrial outer membrane integrity regulates a ubiquitin-dependent and NF-kappaB-mediated inflammatory response. Vringer E, Heilig R, Riley JS, Black A, Cloix C, Skalka G, Montes-Gomez AE, Aguado A, Lilla S, Walczak H, Gyrd-Hansen M, Murphy DJ, Huang DT, Zanivan S, Tait SW. EMBO J. 2024 Mar;43(6):904-930. doi: 10.1038/s44318-024-00044-1. Epub 2024 Feb 9. PubMed |
| A methylation-phosphorylation switch controls EZH2 stability and hematopoiesis. Guo P, Lim RC, Rajawasam K, Trinh T, Sun H, Zhang H. Elife. 2024 Feb 12;13:e86168. doi: 10.7554/eLife.86168. PubMed |
| NSD1 supports cell growth and regulates autophagy in HPV-negative head and neck squamous cell carcinoma. Topchu I, Bychkov I, Gursel D, Makhov P, Boumber Y. Cell Death Discov. 2024 Feb 13;10(1):75. doi: 10.1038/s41420-024-01842-6. PubMed |
| Programmable RNA writing with trans-splicing. Schmitt-Ulms C, Kayabolen A, Manero-Carranza M, Zhou N, Donnelly K, Nuccio SP, Kato K, Nishimasu H, Gootenberg JS, Abudayyeh OO. bioRxiv [Preprint]. 2024 Feb 1:2024.01.31.578223. doi: 10.1101/2024.01.31.578223. PubMed |
| Tsyn-Seq: a T-cell Synapse-Based Antigen Identification Platform. Jin Y, Miyama T, Brown A, Hayase T, Song X, Singh AK, Huang L, Flores II, McDaniel LK, Glover I, Halsey TM, Prasad R, Chapa V, Ahmed S, Zhang J, Rai K, Peterson CB, Lizee G, Karmouch J, Hayase E, Molldrem JJ, Chang CC, Tsai WB, Jenq RR. Cancer Immunol Res. 2024 May 2;12(5):530-543. doi: 10.1158/2326-6066.CIR-23-0467. PubMed |
| Plasticity-induced repression of Irf6 underlies acquired resistance to cancer immunotherapy in pancreatic ductal adenocarcinoma. Kim IK, Diamond MS, Yuan S, Kemp SB, Kahn BM, Li Q, Lin JH, Li J, Norgard RJ, Thomas SK, Merolle M, Katsuda T, Tobias JW, Baslan T, Politi K, Vonderheide RH, Stanger BZ. Nat Commun. 2024 Feb 20;15(1):1532. doi: 10.1038/s41467-024-46048-7. PubMed |
| Chromatin Remodeling in Patient-Derived Colorectal Cancer Models. Xiang K, Wang E, Mantyh J, Rupprecht G, Negrete M, Sanati G, Hsu C, Randon P, Dohlman A, Kretzschmar K, Bose S, Giroux N, Ding S, Wang L, Balcazar JP, Huang Q, Sundaramoorthy P, Xi R, McCall SJ, Wang Z, Jiang C, Kang Y, Kopetz S, Crawford GE, Lipkin SM, Wang XF, Clevers H, Hsu D, Shen X. Adv Sci (Weinh). 2024 Apr;11(16):e2303379. doi: 10.1002/advs.202303379. Epub 2024 Feb 21. PubMed |
| Agent-based modeling of the prostate tumor microenvironment uncovers spatial tumor growth constraints and immunomodulatory properties. van Genderen MNG, Kneppers J, Zaalberg A, Bekers EM, Bergman AM, Zwart W, Eduati F. NPJ Syst Biol Appl. 2024 Feb 21;10(1):20. doi: 10.1038/s41540-024-00344-6. PubMed |
| POZ/BTB and AT hook containing zinc finger 1 (PATZ1) suppresses differentiation and regulates metabolism in human embryonic stem cells. Huang M, Liao X, Wang X, Qian Y, Zhang W, Chen G, Wu Q. Int J Biol Sci. 2024 Jan 21;20(4):1142-1159. doi: 10.7150/ijbs.83927. eCollection 2024. PubMed |
| Open-source milligram-scale, four channel, automated protein purification system. Puccinelli RR, Sama SS, Worthington CM, Puschnik AS, Pak JE, Gomez-Sjoberg R. PLoS One. 2024 Feb 23;19(2):e0297879. doi: 10.1371/journal.pone.0297879. eCollection 2024. PubMed |
| Quantitative MRI Evaluation of Ferritin Overexpression in Non-Small-Cell Lung Cancer. Singhania M, Zaher A, Pulliam CF, Bayanbold K, Searby CC, Schoenfeld JD, Mapuskar KA, Fath MA, Allen BG, Spitz DR, Petronek MS. Int J Mol Sci. 2024 Feb 18;25(4):2398. doi: 10.3390/ijms25042398. PubMed |
| Optimized protocol for CRISPR knockout of human iPSC-derived macrophages. Navarro-Guerrero E, Baronio R, Tay C, Knight JC, Ebner DV. STAR Protoc. 2024 Mar 15;5(1):102903. doi: 10.1016/j.xpro.2024.102903. Epub 2024 Feb 23. PubMed |
| Metformin reduces the clonal fitness of Dnmt3a(R878H) hematopoietic stem and progenitor cells by reversing their aberrant metabolic and epigenetic state. Hosseini M, Voisin V, Chegini A, Varesi A, Cathelin S, Ayyathan DM, Liu ACH, Yang Y, Wang V, Maher A, Grignano E, Reisz JA, D'Alessandro A, Young K, Wu Y, Fiumara M, Ferrari S, Naldini L, Gaiti F, Pai S, Schimmer AD, Bader GD, Dick JE, Xie SZ, Trowbridge JJ, Chan SM. Res Sq [Preprint]. 2024 Feb 6:rs.3.rs-3874821. doi: 10.21203/rs.3.rs-3874821/v1. PubMed |
| Single-genome analysis reveals a heterogeneous association of the herpes simplex virus genome with H3K27me2 and the reader PHF20L1 following infection of human fibroblasts. Francois AK, Rohani A, Loftus M, Dochnal S, Hrit J, McFarlane S, Whitford A, Lewis A, Krakowiak P, Boutell C, Rothbart SB, Kashatus D, Cliffe AR. mBio. 2024 Apr 10;15(4):e0327823. doi: 10.1128/mbio.03278-23. Epub 2024 Feb 27. PubMed |
| E-cadherin loss drives diffuse-type gastric tumorigenesis via EZH2-mediated reprogramming. Zou G, Huang Y, Zhang S, Ko KP, Kim B, Zhang J, Venkatesan V, Pizzi MP, Fan Y, Jun S, Niu N, Wang H, Song S, Ajani JA, Park JI. J Exp Med. 2024 Apr 1;221(4):e20230561. doi: 10.1084/jem.20230561. Epub 2024 Feb 27. PubMed |
| Gene editing-based targeted integration for correction of Wiskott-Aldrich syndrome. Pille M, Avila JM, Park SH, Le CQ, Xue H, Haerynck F, Saxena L, Lee C, Shpall EJ, Bao G, Vandekerckhove B, Davis BR. Mol Ther Methods Clin Dev. 2024 Feb 6;32(1):101208. doi: 10.1016/j.omtm.2024.101208. eCollection 2024 Mar 14. PubMed |
| Integration of transcription regulation and functional genomic data reveals lncRNA SNHG6's role in hematopoietic differentiation and leukemia. Hazan JM, Amador R, Ali-Nasser T, Lahav T, Shotan SR, Steinberg M, Cohen Z, Aran D, Meiri D, Assaraf YG, Guigo R, Bester AC. J Biomed Sci. 2024 Feb 28;31(1):27. doi: 10.1186/s12929-024-01015-8. PubMed |
| The immunopathological landscape of human pre-TCRalpha deficiency: From rare to common variants. Materna M, Delmonte OM, Bosticardo M, Momenilandi M, Conrey PE, Charmeteau-De Muylder B, Bravetti C, Bellworthy R, Cederholm A, Staels F, Ganoza CA, Darko S, Sayed S, Le Floc'h C, Ogishi M, Rinchai D, Guenoun A, Bolze A, Khan T, Gervais A, Kruger R, Voller M, Palterer B, Sadeghi-Shabestari M, Langlois de Septenville A, Schramm CA, Shah S, Tello-Cajiao JJ, Pala F, Amini K, Campos JS, Lima NS, Eriksson D, Levy R, Seeleuthner Y, Jyonouchi S, Ata M, Al Ali F, Stittrich A, Deswarte C, Pereira A, Megret J, Le Voyer T, Bastard P, Berteloot L, Dussiot M, Vladikine N, Cardenas PP, Jouanguy E, Alqahtani M, Hasan A, Thanaraj TA, Rosain J, Al Qureshah F, Sabato V, Alyanakian MA, Leruez-Ville M, Rozenberg F, Haddad E, Regueiro JR, Toribio ML, Kelsen JR, Salehi M, Nasiri S, Torabizadeh M, Rokni-Zadeh H, Changi-Ashtiani M, Vatandoost N, Moravej H, Akrami SM, Mazloomrezaei M, Cobat A, Meyts I, Toyofuku E, Nishimura M, Moriya K, Mizukami T, Imai K, Abel L, Malissen B, Al-Mulla F, Alkuraya FS, Parvaneh N, von Bernuth H, Beetz C, Davi F, Douek DC, Cheynier R, Langlais D, Landegren N, Marr N, Morio T, Shahrooei M, Schrijvers R, Henrickson SE, Luche H, Notarangelo LD, Casanova JL, Beziat V. Science. 2024 Mar;383(6686):eadh4059. doi: 10.1126/science.adh4059. Epub 2024 Mar 1. PubMed |
| Targeting CCL2/CCR2 Signaling Overcomes MEK Inhibitor Resistance in Acute Myeloid Leukemia. Modak RV, de Oliveira Rebola KG, McClatchy J, Mohammadhosseini M, Damnernsawad A, Kurtz SE, Eide CA, Wu G, Laderas T, Nechiporuk T, Gritsenko MA, Hansen JR, Hutchinson C, Gosline SJC, Piehowski P, Bottomly D, Short N, Rodland K, McWeeney SK, Tyner JW, Agarwal A. Clin Cancer Res. 2024 May 15;30(10):2245-2259. doi: 10.1158/1078-0432.CCR-23-2654. PubMed |
| Repeat DNA methylation is modulated by adherens junction signaling. Brenner LM, Meyer F, Yang H, Kohler AR, Bashtrykov P, Guo M, Jeltsch A, Lungu C, Olayioye MA. Commun Biol. 2024 Mar 7;7(1):286. doi: 10.1038/s42003-024-05990-4. PubMed |
CDK-independent role of D-type cyclins in regulating DNA mismatch repair.
Rona G, Miwatani-Minter B, Zhang Q, Goldberg HV, Kerzhnerman MA, Howard JB, Simoneschi D, Lane E, Hobbs JW, Sassani E, Wang AA, Keegan S, Laverty DJ, Piett CG, Pongor LS, Xu ML, Andrade J, Thomas A, Sicinski P, Askenazi M, Ueberheide B, Fenyo D, Nagel ZD, Pagano M.
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Associated Plasmids |
| Aryl hydrocarbon receptor suppresses STING-mediated type I IFN expression in triple-negative breast cancer. Martin JC, da Silva Fernandes T, Chaudhry KA, Oshi M, Abrams SI, Takabe K, Rosario SR, Bianchi-Smiraglia A. Sci Rep. 2024 Mar 8;14(1):5731. doi: 10.1038/s41598-024-54732-3. PubMed |
| Efficient and scalable gene delivery method with easily generated cationic carbon dots. Algarra M, Gonzalez-Munoz E. Biol Proced Online. 2024 Mar 8;26(1):6. doi: 10.1186/s12575-024-00232-7. PubMed |
| O-GlcNAcylation of FOXK1 orchestrates the E2F pathway and promotes oncogenesis. Masclef L, Ahmed O, Iannantuono N, Gagnon J, Gushul-Leclaire M, Boulay K, Estavoyer B, Echbicheb M, Poy M, Boubacar KA, Boubekeur A, Menggad S, Schcolnik-Cabrera A, Balsalobre A, Bonneil E, Thibault P, Hulea L, Tanaka Y, Antoine-Mallette F, Drouin J, Affar EB. bioRxiv [Preprint]. 2024 Mar 1:2024.03.01.582838. doi: 10.1101/2024.03.01.582838. PubMed |
| Kruppel-like Factor (KLF) family members control expression of genes required for serous cavity and alveolar macrophage identities. Pestal K, Slayden LC, Barton GM. bioRxiv [Preprint]. 2024 Mar 3:2024.02.28.582578. doi: 10.1101/2024.02.28.582578. PubMed |
| RNA expression of 6 genes from metastatic mucosal gastric cancer serves as the global prognostic marker for gastric cancer with functional validation. Suh YS, Lee J, George J, Seol D, Jeong K, Oh SY, Bang C, Jun Y, Kong SH, Lee HJ, Kim JI, Kim WH, Yang HK, Lee C. Br J Cancer. 2024 May;130(9):1571-1584. doi: 10.1038/s41416-024-02642-6. Epub 2024 Mar 11. PubMed |
| Structural basis of human U5 snRNP late biogenesis and recycling. Riabov Bassat D, Visanpattanasin S, Vorlander MK, Fin L, Phillips AW, Plaschka C. Nat Struct Mol Biol. 2024 May;31(5):747-751. doi: 10.1038/s41594-024-01243-4. Epub 2024 Mar 11. PubMed |
| Induction of Multiple Alternative Mitogenic Signaling Pathways Accompanies the Emergence of Drug-Tolerant Cancer Cells. Celeste FV, Powers S. Cancers (Basel). 2024 Feb 29;16(5):1001. doi: 10.3390/cancers16051001. PubMed |
| p53 modulates kinase inhibitor resistance and lineage plasticity in NF1-related MPNSTs. Grit JL, McGee LE, Tovar EA, Essenburg CJ, Wolfrum E, Beddows I, Williams K, Sheridan RTC, Schipper JL, Adams M, Arumugam M, Vander Woude T, Gurunathan S, Field JM, Wulfkuhle J, Petricoin EF 3rd, Graveel CR, Steensma MR. Oncogene. 2024 May;43(19):1411-1430. doi: 10.1038/s41388-024-03000-9. Epub 2024 Mar 13. PubMed |
| WW domains form a folded type of nuclear localization signal to guide YAP1 nuclear import. Yang Y, Wu M, Pan Y, Hua Y, He X, Li X, Wang J, Gan X. J Cell Biol. 2024 Jun 3;223(6):e202308013. doi: 10.1083/jcb.202308013. Epub 2024 Mar 15. PubMed |
| Histone H3.1 is a chromatin-embedded redox sensor triggered by tumor cells developing adaptive phenotypic plasticity and multidrug resistance. Palma FR, Coelho DR, Pulakanti K, Sakiyama MJ, Huang Y, Ogata FT, Danes JM, Meyer A, Furdui CM, Spitz DR, Gomes AP, Gantner BN, Rao S, Backman V, Bonini MG. Cell Rep. 2024 Mar 26;43(3):113897. doi: 10.1016/j.celrep.2024.113897. Epub 2024 Mar 16. PubMed |
| Centriole structural integrity defects are a crucial feature of Hydrolethalus Syndrome. Curinha A, Huang Z, Anglen T, Strong MA, Gliech CR, Jewett CE, Friskes A, Holland AJ. bioRxiv [Preprint]. 2024 Mar 6:2024.03.06.583733. doi: 10.1101/2024.03.06.583733. PubMed |
| Combinatorial in vivo genome editing identifies widespread epistasis during lung tumorigenesis. Hebert JD, Tang YJ, Andrejka L, Lopez SS, Petrov DA, Boross G, Winslow MM. bioRxiv [Preprint]. 2024 Mar 8:2024.03.07.583981. doi: 10.1101/2024.03.07.583981. PubMed |
| Zinc Alpha-2-Glycoprotein (ZAG/AZGP1) secreted by triple-negative breast cancer promotes tumor microenvironment fibrosis. Verma S, Giagnocavo SD, Curtin MC, Arumugam M, Osburn-Staker SM, Wang G, Atkinson A, Nix DA, Lum DH, Cox JE, Hilgendorf KI. bioRxiv [Preprint]. 2024 Mar 7:2024.03.04.583349. doi: 10.1101/2024.03.04.583349. PubMed |
| Orphan lysosomal solute carrier MFSD1 facilitates highly selective dipeptide transport. Boytsov D, Madej GM, Horn G, Blaha N, Kocher T, Sitte HH, Siekhaus D, Ziegler C, Sandtner W, Roblek M. Proc Natl Acad Sci U S A. 2024 Mar 26;121(13):e2319686121. doi: 10.1073/pnas.2319686121. Epub 2024 Mar 20. PubMed |
| Targeting of vulnerabilities of drug-tolerant persisters identified through functional genetics delays tumor relapse. Chen M, Mainardi S, Lieftink C, Velds A, de Rink I, Yang C, Kuiken HJ, Morris B, Edwards F, Jochems F, van Tellingen O, Boeije M, Proost N, Jansen RA, Qin S, Jin H, Koen van der Mijn JC, Schepers A, Venkatesan S, Qin W, Beijersbergen RL, Wang L, Bernards R. Cell Rep Med. 2024 Mar 19;5(3):101471. doi: 10.1016/j.xcrm.2024.101471. PubMed |
| FAM86A methylation of eEF2 links mRNA translation elongation to tumorigenesis. Francis JW, Hausmann S, Ikram S, Yin K, Mealey-Farr R, Flores NM, Trinh AT, Chasan T, Thompson J, Mazur PK, Gozani O. Mol Cell. 2024 May 2;84(9):1753-1763.e7. doi: 10.1016/j.molcel.2024.02.037. Epub 2024 Mar 19. PubMed |
| DeltaNp63 regulates MDSC survival and metabolism in triple-negative breast cancer. Kim U, Debnath R, Maiz JE, Rico J, Sinha S, Blanco MA, Chakrabarti R. iScience. 2024 Feb 29;27(4):109366. doi: 10.1016/j.isci.2024.109366. eCollection 2024 Apr 19. PubMed |
| Dux activates metabolism-lactylation-MET network during early iPSC reprogramming with Brg1 as the histone lactylation reader. Hu X, Huang X, Yang Y, Sun Y, Zhao Y, Zhang Z, Qiu D, Wu Y, Wu G, Lei L. Nucleic Acids Res. 2024 Jun 10;52(10):5529-5548. doi: 10.1093/nar/gkae183. PubMed |
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| Absence of c-Maf and IL-10 enables Type I IFN enhancement of innate responses to low-dose LPS in alveolar macrophages. Lim PN, Cervantes MM, Pham LK, Doherty S, Tufts A, Dubey D, Mai D, Aderem A, Diercks AH, Rothchild AC. bioRxiv [Preprint]. 2024 May 26:2024.05.22.594428. doi: 10.1101/2024.05.22.594428. PubMed |
| A genome-scale screen identifies sulfated glycosaminoglycans as pivotal in epithelial cell damage by Candida albicans. Lin J, Miao J, Schaefer KG, Russell CM, Pyron RJ, Zhang F, Phan QT, Solis-Swidergall NV, Liu H, Tashiro M, Dordick JS, Linhardt RJ, Yeaman MR, King GM, Barrera FN, Peters BM, Filler SG. bioRxiv [Preprint]. 2024 May 23:2024.05.23.595417. doi: 10.1101/2024.05.23.595417. PubMed |
Apoptosis signal-regulating kinase 1 promotes inflammation in senescence and aging.
Odawara T, Yamauchi S, Ichijo H.
Commun Biol. 2024 Jun 5;7(1):691. doi: 10.1038/s42003-024-06386-0.
PubMed
Associated Plasmids |
| Lineage specification in glioblastoma is regulated by METTL7B. Constantinou M, Nicholson J, Zhang X, Maniati E, Lucchini S, Rosser G, Vinel C, Wang J, Lim YM, Brandner S, Nelander S, Badodi S, Marino S. Cell Rep. 2024 Jun 25;43(6):114309. doi: 10.1016/j.celrep.2024.114309. Epub 2024 Jun 5. PubMed |
| Caspase-4 promotes metastasis and interferon-gamma-induced pyroptosis in lung adenocarcinoma. Chiba Y, Doi T, Obayashi K, Sumida K, Nagasaka S, Wang KY, Yamasaki K, Masago K, Matsushita H, Kuroda H, Yatera K, Endo M. Commun Biol. 2024 Jun 7;7(1):699. doi: 10.1038/s42003-024-06402-3. PubMed |
| An oncogenic enhancer promotes melanoma progression via regulating ETV4 expression. Zhang J, Wang Q, Qi S, Duan Y, Liu Z, Liu J, Zhang Z, Li C. J Transl Med. 2024 Jun 7;22(1):547. doi: 10.1186/s12967-024-05356-8. PubMed |
| Aging represses lung tumorigenesis and alters tumor suppression. Shuldiner EG, Karmakar S, Tsai MK, Hebert JD, Tang YJ, Andrejka L, Wang M, Detrick CR, Cai H, Tang R, Petrov DA, Winslow MM. bioRxiv [Preprint]. 2024 May 31:2024.05.28.596319. doi: 10.1101/2024.05.28.596319. PubMed |
| Mitochondrial Calcium Signaling Regulates Branched-Chain Amino Acid Catabolism in Fibrolamellar Carcinoma. Marsh NM, MacEwen MJS, Chea J, Kenerson HL, Kwong AA, Locke TM, Miralles FJ, Sapre T, Gozali N, Atilla-Gokcumen GE, Ong SE, Scott JD, Yeung RS, Sancak Y. bioRxiv [Preprint]. 2024 May 28:2024.05.27.596106. doi: 10.1101/2024.05.27.596106. PubMed |
| Alpha-defensin binding expands human adenovirus tropism. Zhao C, Porter JM, Burke PC, Arnberg N, Smith JG. bioRxiv [Preprint]. 2024 May 30:2024.05.30.596681. doi: 10.1101/2024.05.30.596681. PubMed |
Deciphering ER stress-unfolded protein response relationship by visualizing unfolded proteins in the ER.
Xu F, Wang L.
Cell Rep. 2024 Jun 25;43(6):114358. doi: 10.1016/j.celrep.2024.114358. Epub 2024 Jun 11.
PubMed
Associated Plasmids |
| N6-methyladenosine-driven miR-143/145-KLF4 circuit orchestrates the phenotypic switch of pulmonary artery smooth muscle cells. Kang K, Sun C, Li H, Liu X, Deng J, Chen S, Zeng L, Chen J, Liu X, Kuang J, Xiang J, Cheng J, Liao X, Lin M, Zhang X, Zhan C, Liu S, Wang J, Niu Y, Liu C, Liang C, Zhu J, Liang S, Tang H, Gou D. Cell Mol Life Sci. 2024 Jun 12;81(1):256. doi: 10.1007/s00018-024-05304-1. PubMed |
| PD-L1 promotes oncolytic virus infection via a metabolic shift that inhibits the type I IFN pathway. Hodgins JJ, Abou-Hamad J, O'Dwyer CE, Hagerman A, Yakubovich E, Tanese de Souza C, Marotel M, Buchler A, Fadel S, Park MM, Fong-McMaster C, Crupi MF, Makinson OJ, Kurdieh R, Rezaei R, Dhillon HS, Ilkow CS, Bell JC, Harper ME, Rotstein BH, Auer RC, Vanderhyden BC, Sabourin LA, Bourgeois-Daigneault MC, Cook DP, Ardolino M. J Exp Med. 2024 Jul 1;221(7):e20221721. doi: 10.1084/jem.20221721. Epub 2024 Jun 13. PubMed |
| Gain-of-function human UNC93B1 variants cause systemic lupus erythematosus and chilblain lupus. David C, Arango-Franco CA, Badonyi M, Fouchet J, Rice GI, Didry-Barca B, Maisonneuve L, Seabra L, Kechiche R, Masson C, Cobat A, Abel L, Talouarn E, Beziat V, Deswarte C, Livingstone K, Paul C, Malik G, Ross A, Adam J, Walsh J, Kumar S, Bonnet D, Bodemer C, Bader-Meunier B, Marsh JA, Casanova JL, Crow YJ, Manoury B, Fremond ML, Bohlen J, Lepelley A. J Exp Med. 2024 Aug 5;221(8):e20232066. doi: 10.1084/jem.20232066. Epub 2024 Jun 13. PubMed |
| Antiviral activity of intracellular nanobodies targeting the influenza virus RNA-polymerase core. Bessonne M, Morel J, Nevers Q, Da Costa B, Ballandras-Colas A, Chenavier F, Grange M, Roussel A, Crepin T, Delmas B. PLoS Pathog. 2024 Jun 14;20(6):e1011642. doi: 10.1371/journal.ppat.1011642. eCollection 2024 Jun. PubMed |
| Interferon regulatory factor 4 modulates epigenetic silencing and cancer-critical pathways in melanoma cells. Sobhiafshar U, Cakici B, Yilmaz E, Yildiz Ayhan N, Hedaya L, Ayhan MC, Yerinde C, Alankus YB, Gurkaslar HK, Firat-Karalar EN, Emre NCT. Mol Oncol. 2024 Oct;18(10):2423-2448. doi: 10.1002/1878-0261.13672. Epub 2024 Jun 16. PubMed |
| Expression of modified FcgammaRI enables myeloid cells to elicit robust tumor-specific cytotoxicity. Farhat-Younis L, Na M, Zarfin A, Khateeb A, Santana-Magal N, Richter A, Gutwillig A, Rasoulouniriana D, Gleiberman A, Beck L, Giger T, Ashkenazi A, Barzel A, Rider P, Carmi Y. Elife. 2024 Jun 17;12:RP91999. doi: 10.7554/eLife.91999. PubMed |
| Chlormequat Chloride Inhibits TM3 Leydig Cell Growth via Ferroptosis-Initiated Inflammation. Wang X, Kang C, Guo W, Zhang H, Xiao Q, Hao W. Cells. 2024 Jun 5;13(11):979. doi: 10.3390/cells13110979. PubMed |
| RNASeq highlights ATF6 pathway regulators for CHO cell engineering with different impacts of ATF6beta and WFS1 knockdown on fed-batch production of IgG(1). Rives D, Peak C, Blenner MA. Sci Rep. 2024 Jun 19;14(1):14141. doi: 10.1038/s41598-024-64767-1. PubMed |
| Alpha-defensin binding expands human adenovirus tropism. Zhao C, Porter JM, Burke PC, Arnberg N, Smith JG. PLoS Pathog. 2024 Jun 20;20(6):e1012317. doi: 10.1371/journal.ppat.1012317. eCollection 2024 Jun. PubMed |
| Dynamin 1xA interacts with Endophilin A1 via its spliced long C-terminus for ultrafast endocytosis. Imoto Y, Xue J, Luo L, Raychaudhuri S, Itoh K, Ma Y, Craft GE, Kwan AH, Ogunmowo TH, Ho A, Mackay JP, Ha T, Watanabe S, Robinson PJ. EMBO J. 2024 Aug;43(16):3327-3357. doi: 10.1038/s44318-024-00145-x. Epub 2024 Jun 21. PubMed |
pLxIS-containing domains are biochemically flexible regulators of interferons and metabolism.
Landau LM, Chaudhary N, Tien YC, Rogozinska M, Joshi S, Yao C, Crowley J, Hullahalli K, Campbell IW, Waldor MK, Haigis M, Kagan JC.
Mol Cell. 2024 Jul 11;84(13):2436-2454.e10. doi: 10.1016/j.molcel.2024.05.030. Epub 2024 Jun 25.
PubMed
Associated Plasmids |
| The exocyst subunit EXOC2 regulates the toxicity of expanded GGGGCC repeats in C9ORF72-ALS/FTD. Halim DO, Krishnan G, Hass EP, Lee S, Verma M, Almeida S, Gu Y, Kwon DY, Fazzio TG, Gao FB. Cell Rep. 2024 Jul 23;43(7):114375. doi: 10.1016/j.celrep.2024.114375. Epub 2024 Jun 26. PubMed |
| CRISPR-Cas9 screening reveals a distinct class of MHC-I binders with precise HLA-peptide recognition. Schoufour TAW, van der Plas-van Duijn A, Derksen I, Melgers M, van Veenendaal JMF, Lensen C, Heemskerk MHM, Neefjes J, Wijdeven RHM, Scheeren FA. iScience. 2024 May 27;27(6):110120. doi: 10.1016/j.isci.2024.110120. eCollection 2024 Jun 21. PubMed |
| Linoleic acid-derived diol 12,13-DiHOME enhances NLRP3 inflammasome activation in macrophages. Valencia R, Kranrod JW, Fang L, Soliman AM, Azer B, Clemente-Casares X, Seubert JM. FASEB J. 2024 Jul 15;38(13):e23748. doi: 10.1096/fj.202301640RR. PubMed |
| The centrosomal protein FGFR1OP controls myosin function in murine intestinal epithelial cells. Trsan T, Peng V, Krishna C, Ohara TE, Beatty WL, Sudan R, Kanai M, Krishnamoorthy P, Rodrigues PF, Fachi JL, Grajales-Reyes G, Jaeger N, Fitzpatrick JAJ, Cella M, Gilfillan S, Nakata T, Jaiswal A, Stappenbeck TS, Daly MJ, Xavier RJ, Colonna M. Dev Cell. 2024 Sep 23;59(18):2460-2476.e10. doi: 10.1016/j.devcel.2024.06.001. Epub 2024 Jun 27. PubMed |
| IRF4 impedes human CD8 T cell function and promotes cell proliferation and PD-1 expression. Hirsch T, Neyens D, Duhamel C, Bayard A, Vanhaver C, Luyckx M, Sala de Oyanguren F, Wildmann C, Dauguet N, Squifflet JL, Montiel V, Deschamps M, van der Bruggen P. Cell Rep. 2024 Jul 23;43(7):114401. doi: 10.1016/j.celrep.2024.114401. Epub 2024 Jun 27. PubMed |
| Chemo-small extracellular vesicles released in cisplatin-resistance ovarian cancer cells are regulated by the lysosomal function. Cerda-Troncoso C, Grunenwald F, Arias-Munoz E, Cavieres VA, Caceres-Verschae A, Hernandez S, Gaete-Ramirez B, Alvarez-Astudillo F, Acuna RA, Ostrowski M, Burgos PV, Varas-Godoy M. J Extracell Biol. 2024 May 30;3(6):e157. doi: 10.1002/jex2.157. eCollection 2024 Jun. PubMed |
| An HIV-1 CRISPR-Cas9 membrane trafficking screen reveals a role for PICALM intersecting endolysosomes and immunity. Guizar P, Abdalla AL, Monette A, Davis K, Caballero RE, Niu M, Liu X, Ajibola O, Murooka TT, Liang C, Mouland AJ. iScience. 2024 May 27;27(6):110131. doi: 10.1016/j.isci.2024.110131. eCollection 2024 Jun 21. PubMed |
SigmaR1 shapes rough endoplasmic reticulum membrane sheets.
Sawyer EM, Jensen LE, Meehl JB, Larsen KP, Petito DA, Hurley JH, Voeltz GK.
Dev Cell. 2024 Jul 2:S1534-5807(24)00382-4. doi: 10.1016/j.devcel.2024.06.005.
PubMed
Associated Plasmids |
| Genetic ablation of adhesion ligands mitigates rejection of allogeneic cellular immunotherapies. Hammer Q, Perica K, Mbofung RM, van Ooijen H, Martin KE, Momayyezi P, Varady E, Pan Y, Jelcic M, Groff B, Abujarour R, Krokeide SZ, Lee T, Williams A, Goodridge JP, Valamehr B, Onfelt B, Sadelain M, Malmberg KJ. Cell Stem Cell. 2024 Sep 5;31(9):1376-1386.e8. doi: 10.1016/j.stem.2024.06.011. Epub 2024 Jul 8. PubMed |
| Slc25a3-dependent copper transport controls flickering-induced Opa1 processing for mitochondrial safeguard. Murata D, Roy S, Lutsenko S, Iijima M, Sesaki H. Dev Cell. 2024 Oct 7;59(19):2578-2592.e7. doi: 10.1016/j.devcel.2024.06.008. Epub 2024 Jul 9. PubMed |
| PP2A B55alpha inhibits epithelial-mesenchymal transition via regulation of Slug expression in non-small cell lung cancer. Singh D, Qiu Z, Jonathan SM, Fa P, Thomas H, Prasad CB, Cai S, Wang JJ, Yan C, Zhang X, Venere M, Li Z, Sizemore ST, Wang QE, Zhang J. Cancer Lett. 2024 Aug 28;598:217110. doi: 10.1016/j.canlet.2024.217110. Epub 2024 Jul 8. PubMed |
| Local vascular Klotho mediates diabetes-induced atherosclerosis via ERK1/2 and PI3-kinase-dependent signaling pathways. Ajay AK, Zhu LJ, Zhao L, Liu Q, Ding Y, Chang YC, Shah SI, Hsiao LL. Atherosclerosis. 2024 Sep;396:118531. doi: 10.1016/j.atherosclerosis.2024.118531. Epub 2024 Jul 3. PubMed |
| Identification and characterization of TM4SF1(+) tumor self-seeded cells. Yang H, Wang H, He Y, Yang Y, Thompson EW, Xia D, Burke LJ, Cao L, Hooper JD, Roberts MS, Crawford DHG, Liang X. Cell Rep. 2024 Jul 23;43(7):114512. doi: 10.1016/j.celrep.2024.114512. Epub 2024 Jul 13. PubMed |
| Co-option of mitochondrial nucleic acid sensing pathways by HSV-1 UL12.5 for reactivation from latent Infection. Cuddy SR, Flores ME, Krakowiak PA, Whitford AL, Dochnal SA, Babnis A, Miyake T, Tigano M, Engel DA, Cliffe AR. bioRxiv [Preprint]. 2024 Jul 9:2024.07.06.601241. doi: 10.1101/2024.07.06.601241. PubMed |
| Phosphorylation of GCN2 by mTOR confers adaptation to conditions of hyper-mTOR activation under stress. Darawshi O, Yassin O, Shmuel M, Wek RC, Mahdizadeh SJ, Eriksson LA, Hatzoglou M, Tirosh B. J Biol Chem. 2024 Aug;300(8):107575. doi: 10.1016/j.jbc.2024.107575. Epub 2024 Jul 14. PubMed |
| Acute BRCAness Induction and AR Signaling Blockage through CDK12/7/9 Degradation Enhances PARP Inhibitor Sensitivity in Prostate Cancer. Gui F, Jiang B, Jiang J, He Z, Tsujino T, Takai T, Arai S, Pana C, Kollermann J, Bradshaw GA, Eisert R, Kalocsay M, Fassl A, Balk SP, Kibel AS, Jia L. bioRxiv [Preprint]. 2024 Nov 7:2024.07.09.602803. doi: 10.1101/2024.07.09.602803. PubMed |
| LILRB1-HLA-G axis defines a checkpoint driving natural killer cell exhaustion in tuberculosis. Wang J, Chai Q, Lei Z, Wang Y, He J, Ge P, Lu Z, Qiang L, Zhao D, Yu S, Qiu C, Zhong Y, Li BX, Zhang L, Pang Y, Gao GF, Liu CH. EMBO Mol Med. 2024 Aug;16(8):1755-1790. doi: 10.1038/s44321-024-00106-1. Epub 2024 Jul 19. PubMed |
| Investigation of a fluorescent reporter microenvironment niche labeling strategy in experimental brain metastasis. Massara M, Dolfi B, Wischnewski V, Nolan E, Held W, Malanchi I, Joyce JA. iScience. 2024 Jun 15;27(7):110284. doi: 10.1016/j.isci.2024.110284. eCollection 2024 Jul 19. PubMed |
| Metastatic breast cancer cells are metabolically reprogrammed to maintain redox homeostasis during metastasis. Biondini M, Lehuede C, Tabaries S, Annis MG, Pacis A, Ma EH, Tam C, Hsu BE, Audet-Delage Y, Abu-Thuraia A, Girondel C, Sabourin V, Totten SP, de Sa Tavares Russo M, Bridon G, Avizonis D, Guiot MC, St-Pierre J, Ursini-Siegel J, Jones R, Siegel PM. Redox Biol. 2024 Sep;75:103276. doi: 10.1016/j.redox.2024.103276. Epub 2024 Jul 20. PubMed |
| Modulations of the mTORC2-GATA3 axis by an isorhamnetin activated endosomal-lysosomal system of the J774.1 macrophage-like cell line. Sakai M, Ohnishi K, Masuda M, Harumoto E, Fukuda T, Ohnishi A, Ishii S, Ohminami H, Yamanaka-Okumura H, Ohashi K, Itakura E, Horikawa K, Yonemura S, Hara T, Taketani Y. J Clin Biochem Nutr. 2024 Jul;75(1):24-32. doi: 10.3164/jcbn.24-22. Epub 2024 Mar 20. PubMed |
| IMPDH2 filaments protect from neurodegeneration in AMPD2 deficiency. Flores-Mendez M, Ohl L, Roule T, Zhou Y, Tintos-Hernandez JA, Walsh K, Ortiz-Gonzalez XR, Akizu N. EMBO Rep. 2024 Sep;25(9):3990-4012. doi: 10.1038/s44319-024-00218-2. Epub 2024 Jul 29. PubMed |
| UNC13B regulates the sensitivity of Wilms' tumor cells to doxorubicin by modulating lysosomes. Chen X, Bao Y, Sun G, Wang X, Zhu J. Oncol Lett. 2024 Jul 22;28(3):446. doi: 10.3892/ol.2024.14579. eCollection 2024 Sep. PubMed |
| Multi-species genome-wide CRISPR screens identify conserved suppressors of cold-induced cell death. Lam B, Kajderowicz KM, Keys HR, Roessler JM, Frenkel EM, Kirkland A, Bisht P, El-Brolosy MA, Jaenisch R, Bell GW, Weissman JS, Griffith EC, Hrvatin S. bioRxiv [Preprint]. 2024 Nov 19:2024.07.25.605098. doi: 10.1101/2024.07.25.605098. PubMed |
| SLC45A4 encodes a mitochondrial putrescine transporter that promotes GABA de novo synthesis. Colson C, Wang Y, Atherton J, Su X. bioRxiv [Preprint]. 2024 Jul 24:2024.07.23.604788. doi: 10.1101/2024.07.23.604788. PubMed |
| Normalization of Snai1-mediated vessel dysfunction increases drug response in cancer. Hoffmann H, Wartenberg M, Vorlova S, Karl-Scholler F, Kallius M, Reinhardt O, Ozturk A, Schuhmair LS, Burkhardt V, Gatzner S, Scheld D, Nandigama R, Zernecke A, Herterich S, Ergun S, Rosenwald A, Henke E. Oncogene. 2024 Aug;43(35):2661-2676. doi: 10.1038/s41388-024-03113-1. Epub 2024 Aug 2. PubMed |
| SETDB1 suppresses NK cell-mediated immunosurveillance in acute myeloid leukemia with granulo-monocytic differentiation. Chang YH, Yamamoto K, Fujino T, Wang TW, Sugimoto E, Zhang W, Yabushita T, Suzaki K, Pietsch EC, Weir BA, Crescenzo R, Cowley GS, Attar R, Philippar U, Wunderlich M, Mizukawa B, Zheng Y, Enomoto Y, Imai Y, Kitamura T, Goyama S. Cell Rep. 2024 Aug 27;43(8):114536. doi: 10.1016/j.celrep.2024.114536. Epub 2024 Aug 2. PubMed |
| Proximity labeling reveals dynamic changes in the SQSTM1 protein network. Rondon-Ortiz AN, Zhang L, Ash PEA, Basu A, Puri S, van der Spek SJF, Wang Z, Dorrian L, Emili A, Wolozin B. J Biol Chem. 2024 Sep;300(9):107621. doi: 10.1016/j.jbc.2024.107621. Epub 2024 Aug 3. PubMed |
The interferon gamma pathway enhances pluripotency and X-chromosome reactivation in iPSC reprogramming.
Barrero M, Lazarenkov A, Blanco E, Palma LG, Lopez-Rubio AV, Bauer M, Bigas A, Di Croce L, Sardina JL, Payer B.
Sci Adv. 2024 Aug 9;10(32):eadj8862. doi: 10.1126/sciadv.adj8862. Epub 2024 Aug 7.
PubMed
Associated Plasmids |
| SNORD88B-mediated WRN nucleolar trafficking drives self-renewal in liver cancer initiating cells and hepatocarcinogenesis. Gu Y, Yi Z, Zhou Z, Wang J, Li S, Zhu P, Liu N, Xu Y, He L, Wang Y, Fan Z. Nat Commun. 2024 Aug 7;15(1):6730. doi: 10.1038/s41467-024-50987-6. PubMed |
| Oxysterole-binding protein targeted by SARS-CoV-2 viral proteins regulates coronavirus replication. Ma-Lauer Y, Li P, Niemeyer D, Richter A, Pusl K, von Brunn B, Ru Y, Xiang C, Schwinghammer S, Liu J, Baral P, Berthold EJ, Qiu H, Roy A, Kremmer E, Flaswinkel H, Drosten C, Jin Z, von Brunn A. Front Cell Infect Microbiol. 2024 Jul 25;14:1383917. doi: 10.3389/fcimb.2024.1383917. eCollection 2024. PubMed |
| A Novel Luciferase-Based Reporter Gene Technology for Simultaneous Optical and Radionuclide Imaging of Cells. Gaspar N, Handula M, Stroet MCM, Marella-Panth K, Haeck J, Kirkland TA, Hall MP, Encell LP, Dalm S, Lowik C, Seimbille Y, Mezzanotte L. Int J Mol Sci. 2024 Jul 27;25(15):8206. doi: 10.3390/ijms25158206. PubMed |
| Role of a holo-insertase complex in the biogenesis of biophysically diverse ER membrane proteins. Page KR, Nguyen VN, Pleiner T, Tomaleri GP, Wang ML, Guna A, Hazu M, Wang TY, Chou TF, Voorhees RM. Mol Cell. 2024 Sep 5;84(17):3302-3319.e11. doi: 10.1016/j.molcel.2024.08.005. Epub 2024 Aug 21. PubMed |
| miR-449a mediated repression of the cell cycle machinery prevents neuronal apoptosis. Chauhan M, Singh K, Chongtham C, A G A, Sharma P. J Biol Chem. 2024 Sep;300(9):107698. doi: 10.1016/j.jbc.2024.107698. Epub 2024 Aug 22. PubMed |
| TRIP13 regulates progression of gastric cancer through stabilising the expression of DDX21. Zhang G, Yang R, Wang B, Yan Q, Zhao P, Zhang J, Su W, Yang L, Cui H. Cell Death Dis. 2024 Aug 26;15(8):622. doi: 10.1038/s41419-024-07012-x. PubMed |
| Cysteine-rich with EGF-like domains 2 (CRELD2) is an endoplasmic reticulum stress-inducible angiogenic growth factor promoting ischemic heart repair. Wu X, Zheng L, Reboll MR, Hyde LF, Mass E, Niessen HW, Kosanke M, Pich A, Giannitsis E, Tillmanns J, Bauersachs J, Heineke J, Wang Y, Korf-Klingebiel M, Polten F, Wollert KC. Nat Cardiovasc Res. 2024 Feb;3(2):186-202. doi: 10.1038/s44161-023-00411-x. Epub 2024 Jan 17. PubMed |
| P53-dependent hypusination of eIF5A affects mitochondrial translation and senescence immune surveillance. Jiang X, Baig AH, Palazzo G, Del Pizzo R, Bortecen T, Groessl S, Zaal EA, Amaya Ramirez CC, Kowar A, Aviles-Huerta D, Berkers CR, Palm W, Tschaharganeh D, Krijgsveld J, Loayza-Puch F. Nat Commun. 2024 Aug 28;15(1):7458. doi: 10.1038/s41467-024-51901-w. PubMed |
| Tuberculosis in otherwise healthy adults with inherited TNF deficiency. Arias AA, Neehus AL, Ogishi M, Meynier V, Krebs A, Lazarov T, Lee AM, Arango-Franco CA, Yang R, Orrego J, Corcini Berndt M, Rojas J, Li H, Rinchai D, Erazo-Borras L, Han JE, Pillay B, Ponsin K, Chaldebas M, Philippot Q, Bohlen J, Rosain J, Le Voyer T, Janotte T, Amarajeeva K, Soudee C, Brollo M, Wiegmann K, Marquant Q, Seeleuthner Y, Lee D, Laine C, Kloos D, Bailey R, Bastard P, Keating N, Rapaport F, Khan T, Moncada-Velez M, Carmona MC, Obando C, Alvarez J, Catano JC, Martinez-Rosado LL, Sanchez JP, Tejada-Giraldo M, L'Honneur AS, Agudelo ML, Perez-Zapata LJ, Arboleda DM, Alzate JF, Cabarcas F, Zuluaga A, Pelham SJ, Ensser A, Schmidt M, Velasquez-Lopera MM, Jouanguy E, Puel A, Kronke M, Ghirardello S, Borghesi A, Pahari S, Boisson B, Pittaluga S, Ma CS, Emile JF, Notarangelo LD, Tangye SG, Marr N, Lachmann N, Salvator H, Schlesinger LS, Zhang P, Glickman MS, Nathan CF, Geissmann F, Abel L, Franco JL, Bustamante J, Casanova JL, Boisson-Dupuis S. Nature. 2024 Sep;633(8029):417-425. doi: 10.1038/s41586-024-07866-3. Epub 2024 Aug 28. PubMed |
| Targeting Grb2 SH3 Domains with Affimer Proteins Provides Novel Insights into Ras Signalling Modulation. Tang AAS, Macdonald A, McPherson MJ, Tomlinson DC. Biomolecules. 2024 Aug 22;14(8):1040. doi: 10.3390/biom14081040. PubMed |
| ICAM1 (CD54) Contributes to the Metastatic Capacity of Gastric Cancer Stem Cells. Tinajero-Rodriguez JM, Ramirez-Vidal L, Becerril-Rico J, Alvarado-Ortiz E, Romero-Rodriguez DP, Lopez-Casillas F, Hernandez-Sotelo D, Fernandez-Ramirez F, Contreras-Paredes A, Ortiz-Sanchez E. Int J Mol Sci. 2024 Aug 14;25(16):8865. doi: 10.3390/ijms25168865. PubMed |
| Mannose receptor (MRC1) mediates uptake of dextran in macrophages via receptor-mediated endocytosis. Wollman J, Wanniarachchi K, Pradhan B, Huang L, Kerkvliet JG, Hoppe AD, Thiex NW. bioRxiv [Preprint]. 2024 Aug 13:2024.08.13.607841. doi: 10.1101/2024.08.13.607841. PubMed |
| Multi-omic lineage tracing predicts the transcriptional, epigenetic and genetic determinants of cancer evolution. Nadalin F, Marzi MJ, Pirra Piscazzi M, Fuentes-Bravo P, Procaccia S, Climent M, Bonetti P, Rubolino C, Giuliani B, Papatheodorou I, Marioni JC, Nicassio F. Nat Commun. 2024 Sep 1;15(1):7609. doi: 10.1038/s41467-024-51424-4. PubMed |
| RBN-2397, a PARP7 Inhibitor, Synergizes with Paclitaxel to Inhibit Proliferation and Migration of Ovarian Cancer Cells. Spirtos AN, Aljardali MW, Challa S, Koul S, Lea JS, Kraus WL, Camacho CV. bioRxiv [Preprint]. 2024 Sep 5:2024.08.20.608802. doi: 10.1101/2024.08.20.608802. PubMed |
| HIV-1 Vpu induces neurotoxicity by promoting Caspase 3-dependent cleavage of TDP-43. Yang J, Li Y, Li H, Zhang H, Guo H, Zheng X, Yu XF, Wei W. EMBO Rep. 2024 Oct;25(10):4337-4357. doi: 10.1038/s44319-024-00238-y. Epub 2024 Sep 6. PubMed |
Small-molecule GSDMD agonism in tumors stimulates antitumor immunity without toxicity.
Fontana P, Du G, Zhang Y, Zhang H, Vora SM, Hu JJ, Shi M, Tufan AB, Healy LB, Xia S, Lee DJ, Li Z, Baldominos P, Ru H, Luo HR, Agudo J, Lieberman J, Wu H.
Cell. 2024 Sep 2:S0092-8674(24)00898-5. doi: 10.1016/j.cell.2024.08.007.
PubMed
Associated Plasmids |
Genetically encoded fluorescent reporter for polyamines.
Sharma P, Kim CY, Keys HR, Imada S, Joseph AB, Ferro L, Kunchok T, Anderson R, Yilmaz O, Weng JK, Jain A.
bioRxiv [Preprint]. 2024 Nov 17:2024.08.24.609500. doi: 10.1101/2024.08.24.609500.
PubMed
Associated Plasmids |
| Neuroendocrine Differentiation in Prostate Cancer Requires ASCL1. Rodarte KE, Nir Heyman S, Guo L, Flores L, Savage TK, Villarreal J, Deng S, Xu L, Shah RB, Oliver TG, Johnson JE. Cancer Res. 2024 Nov 4;84(21):3522-3537. doi: 10.1158/0008-5472.CAN-24-1388. PubMed |
| Glaesserella parasuis serotype 4 exploits fibronectin via RlpA for tracheal colonization following porcine circovirus type 2 infection. Guo M, Li Y, Tang J, Wang Q, Wang Q, Zhou H, Lin H, Ma Z, Fan H. PLoS Pathog. 2024 Sep 12;20(9):e1012513. doi: 10.1371/journal.ppat.1012513. eCollection 2024 Sep. PubMed |
ERK5 suppression overcomes FAK inhibitor resistance in mutant KRAS-driven non-small cell lung cancer.
Pozzato C, Outeiro-Pinho G, Galie M, Ramadori G, Konstantinidou G.
EMBO Mol Med. 2024 Sep 13. doi: 10.1038/s44321-024-00138-7.
PubMed
Associated Plasmids |
| A Comparison of Two Versions of the CRISPR-Sirius System for the Live-Cell Visualization of the Borders of Topologically Associating Domains. Viushkov VS, Lomov NA, Rubtsov MA. Cells. 2024 Aug 27;13(17):1440. doi: 10.3390/cells13171440. PubMed |
| Breast Cancer Stem Cells Upregulate IRF6 in Stromal Fibroblasts to Induce Stromagenesis. Muralidharan H, Hansen T, Steinle A, Schumacher D, Stickeler E, Maurer J. Cells. 2024 Aug 31;13(17):1466. doi: 10.3390/cells13171466. PubMed |
| CCR2 cooperativity promotes hematopoietic stem cell homing to the bone marrow. Hurwitz SN, Kobulsky DR, Jung SK, Chia JJ, Butler JM, Kurre P. Sci Adv. 2024 Sep 20;10(38):eadq1476. doi: 10.1126/sciadv.adq1476. Epub 2024 Sep 18. PubMed |
| Neddylation signaling inactivation by tetracaine hydrochloride suppresses cell proliferation and alleviates vemurafenib-resistance of melanoma. Huang X, Yi P, Gou W, Zhang R, Wu C, Liu L, He Y, Jiang X, Feng J. Cell Biol Toxicol. 2024 Sep 19;40(1):81. doi: 10.1007/s10565-024-09916-y. PubMed |
| Epstein-Barr virus induces host shutoff extensively via BGLF5-independent mechanisms. Casco A, Ohashi M, Johannsen E. Cell Rep. 2024 Oct 22;43(10):114743. doi: 10.1016/j.celrep.2024.114743. Epub 2024 Sep 18. PubMed |
| ARID1A overexpression inhibits colorectal cancer cell migration through the regulation of epithelial‑mesenchymal transition. Wanna-Udom S, Aluksanasuwan S, Somsuan K, Mongkolwat W, Sakulsak N. Mol Med Rep. 2024 Nov;30(5):201. doi: 10.3892/mmr.2024.13325. Epub 2024 Sep 20. PubMed |
| mCAUSE: Prioritizing mitochondrial targets that alleviate pancreatic cancer cell phenotypes. Murata D, Ito F, Tang G, Iwata W, Yeung N, West JJ, Ewald AJ, Wang X, Iijima M, Sesaki H. iScience. 2024 Sep 3;27(9):110880. doi: 10.1016/j.isci.2024.110880. eCollection 2024 Sep 20. PubMed |
| EspH utilizes phosphoinositide and Rab binding domains to interact with plasma membrane infection sites and Rab GTPases. Nandi I, Ramachandran RP, Shalev DE, Schneidman-Duhovny D, Shtuhin-Rahav R, Melamed-Book N, Zlotkin-Rivkin E, Rouvinski A, Rosenshine I, Aroeti B. Gut Microbes. 2024 Jan-Dec;16(1):2400575. doi: 10.1080/19490976.2024.2400575. Epub 2024 Sep 23. PubMed |
| MTA-cooperative PRMT5 inhibitors enhance T cell-mediated antitumor activity in MTAP-loss tumors. Chen S, Hou J, Jaffery R, Guerrero A, Fu R, Shi L, Zheng N, Bohat R, Egan NA, Yu C, Sharif S, Lu Y, He W, Wang S, Gjuka D, Stone EM, Shah PA, Rodon Ahnert J, Chen T, Liu X, Bedford MT, Xu H, Peng W. J Immunother Cancer. 2024 Sep 23;12(9):e009600. doi: 10.1136/jitc-2024-009600. PubMed |
| A disease-associated PPP2R3C-MAP3K1 phospho-regulatory module controls centrosome function. Ganga AK, Sweeney LK, Rubio Ramos A, Wrinn CM, Bishop CS, Hamel V, Guichard P, Breslow DK. Curr Biol. 2024 Oct 21;34(20):4824-4834.e6. doi: 10.1016/j.cub.2024.08.058. Epub 2024 Sep 23. PubMed |
| Droplet-based functional CRISPR screening of cell-cell interactions by SPEAC-seq. Faust Akl C, Linnerbauer M, Li Z, Lee HG, Clark IC, Wheeler MA, Quintana FJ. Nat Protoc. 2025 Feb;20(2):440-461. doi: 10.1038/s41596-024-01056-1. Epub 2024 Sep 26. PubMed |
| FGF23 and Cell Stress in SaOS-2 Cells-A Model Reflecting X-Linked Hypophosphatemia Dynamics. Brueck L, Roocke S, Matschke V, Richter-Unruh A, Marcus-Alic K, Theiss C, Stahlke S. Cells. 2024 Sep 10;13(18):1515. doi: 10.3390/cells13181515. PubMed |
| Clustered macrophages cooperate to eliminate tumors via coordinated intrudopodia. Dooling LJ, Anlas AA, Tobin MP, Ontko NM, Marchena T, Wang M, Andrechak JC, Discher DE. bioRxiv [Preprint]. 2024 Sep 20:2024.09.19.613918. doi: 10.1101/2024.09.19.613918. PubMed |
| Hypoxia-induced TGFBI maintains glioma stem cells by stabilizing EphA2. Chen Z, Wang J, Peng P, Liu G, Dong M, Zhang X, Zhang Y, Yang X, Wan L, Xiang W, Zhang S, Zhang B, Wu Q, Yu X, Wan F. Theranostics. 2024 Sep 9;14(15):5778-5792. doi: 10.7150/thno.95141. eCollection 2024. PubMed |
| Corrigendum to "A retrospective study on the clinical and molecular outcomes of calpainopathy in a Turkish patient cohort": [Turkish Journal of Medical Sciences 54 (1) 2024 86-98]. Sahin IO, Karatas E, Demir M, Tan B, Per H, Ozkul Y, Dundar M. Turk J Med Sci. 2024 Sep 30;54(4):880. doi: 10.55730/1300-0144.5861. eCollection 2024. PubMed |
| CRISPR-Cas9 screens reveal regulators of ageing in neural stem cells. Ruetz TJ, Pogson AN, Kashiwagi CM, Gagnon SD, Morton B, Sun ED, Na J, Yeo RW, Leeman DS, Morgens DW, Tsui CK, Li A, Bassik MC, Brunet A. Nature. 2024 Oct;634(8036):1150-1159. doi: 10.1038/s41586-024-07972-2. Epub 2024 Oct 2. PubMed |
| SNX27:Retromer:ESCPE-1-mediated early endosomal tubulation impacts cytomegalovirus replication. Stimac I, Marcelic M, Radic B, Viduka I, Blagojevic Zagorac G, Lukanovic Juric S, Rozmanic C, Messerle M, Brizic I, Lucin P, Mahmutefendic Lucin H. Front Cell Infect Microbiol. 2024 Sep 18;14:1399761. doi: 10.3389/fcimb.2024.1399761. eCollection 2024. PubMed |
| Nuclear and cytosolic fractions of SOX2 synergize as transcriptional and translational co-regulators of cell fate. Schaefer T, Mittal N, Wang H, Ataman M, Candido S, Lotscher J, Velychko S, Tintignac L, Bock T, Borsch A, Bassler J, Rao TN, Zmajkovic J, Roffeis S, Loliger J, Jacob F, Dumlin A, Schurch C, Schmidt A, Skoda RC, Wymann MP, Hess C, Scholer HR, Zaehres H, Hurt E, Zavolan M, Lengerke C. Cell Rep. 2024 Oct 22;43(10):114807. doi: 10.1016/j.celrep.2024.114807. Epub 2024 Oct 3. PubMed |
| Multi-omic human pancreatic islet endoplasmic reticulum and cytokine stress response mapping provides type 2 diabetes genetic insights. Sokolowski EK, Kursawe R, Selvam V, Bhuiyan RM, Thibodeau A, Zhao C, Spracklen CN, Ucar D, Stitzel ML. Cell Metab. 2024 Nov 5;36(11):2468-2488.e7. doi: 10.1016/j.cmet.2024.09.006. Epub 2024 Oct 8. PubMed |
| Unraveling the metastasis-preventing effect of miR-200c in vitro and in vivo. Kohler B, Brieger E, Brandstatter T, Horterer E, Wilk U, Pohmerer J, Jotten A, Paulitschke P, Broedersz CP, Zahler S, Radler JO, Wagner E, Roidl A. Mol Oncol. 2025 Apr;19(4):1029-1053. doi: 10.1002/1878-0261.13712. Epub 2024 Oct 15. PubMed |
Transient proliferation by reversible YAP and mitogen-control of the cyclin D1/p27 ratio.
Ferrick KR, Fan Y, Ratnayeke N, Teruel MN, Meyer T.
bioRxiv [Preprint]. 2024 Nov 4:2024.10.11.617852. doi: 10.1101/2024.10.11.617852.
PubMed
Associated Plasmids |
| PLD3 and PLD4 synthesize S,S-BMP, a key phospholipid enabling lipid degradation in lysosomes. Singh S, Dransfeld UE, Ambaw YA, Lopez-Scarim J, Farese RV Jr, Walther TC. Cell. 2024 Nov 27;187(24):6820-6834.e24. doi: 10.1016/j.cell.2024.09.036. Epub 2024 Oct 17. PubMed |
| Manipulation of DHPS activity affects dendritic morphology and expression of synaptic proteins in primary rat cortical neurons. Cavalli P, Raffauf A, Passarella S, Helmuth M, Dieterich DC, Landgraf P. Front Cell Neurosci. 2024 Oct 14;18:1465011. doi: 10.3389/fncel.2024.1465011. eCollection 2024. PubMed |
| NUP98 fusion proteins and KMT2A-MENIN antagonize PRC1.1 to drive gene expression in AML. Heikamp EB, Martucci C, Henrich JA, Neel DS, Mahendra-Rajah S, Rice H, Wenge DV, Perner F, Wen Y, Hatton C, Armstrong SA. Cell Rep. 2024 Nov 26;43(11):114901. doi: 10.1016/j.celrep.2024.114901. Epub 2024 Oct 30. PubMed |
| LMAN1 serves as a cargo receptor for thrombopoietin. Everett LA, Lin Z, Friedman A, Tang VT, Myers G, Balbin-Cuesta G, King R, Zhu G, McGee B, Khoriaty R. JCI Insight. 2024 Dec 20;9(24):e175704. doi: 10.1172/jci.insight.175704. PubMed |
| Targeting ketone body metabolism in mitigating gemcitabine resistance. Rohena-Rivera K, You S, Kim M, Billet S, Ten Hoeve J, Gonzales G, Huang C, Heard A, Chan KS, Bhowmick NA. JCI Insight. 2024 Dec 20;9(24):e177840. doi: 10.1172/jci.insight.177840. PubMed |
| Calcium signaling from damaged lysosomes induces cytoprotective stress granules. Duran J, Salinas JE, Wheaton RP, Poolsup S, Allers L, Rosas-Lemus M, Chen L, Cheng Q, Pu J, Salemi M, Phinney B, Ivanov P, Lystad AH, Bhaskar K, Rajaiya J, Perkins DJ, Jia J. EMBO J. 2024 Dec;43(24):6410-6443. doi: 10.1038/s44318-024-00292-1. Epub 2024 Nov 12. PubMed |
| Acute multi-level response to defective de novo chromatin assembly in S-phase. Dreyer J, Ricci G, van den Berg J, Bhardwaj V, Funk J, Armstrong C, van Batenburg V, Sine C, VanInsberghe MA, Tjeerdsma RB, Marsman R, Mandemaker IK, di Sanzo S, Costantini J, Manzo SG, Biran A, Burny C, van Vugt MATM, Volker-Albert M, Groth A, Spencer SL, van Oudenaarden A, Mattiroli F. Mol Cell. 2024 Dec 19;84(24):4711-4728.e10. doi: 10.1016/j.molcel.2024.10.023. Epub 2024 Nov 12. PubMed |
| IL-21/IL-21R signaling renders acute myeloid leukemia stem cells more susceptible to cytarabine treatment and CAR T cell therapy. Rubino V, Huppi M, Hopner S, Tortola L, Schnuriger N, Legenne H, Taylor L, Voggensperger S, Keller I, Bruggman R, Kronig MN, Bacher U, Kopf M, Ochsenbein AF, Riether C. Cell Rep Med. 2024 Nov 19;5(11):101826. doi: 10.1016/j.xcrm.2024.101826. Epub 2024 Nov 12. PubMed |
Granulins rescue inflammation, lysosome dysfunction, lipofuscin, and neuropathology in a mouse model of progranulin deficiency.
Root J, Mendsaikhan A, Taylor G, Merino P, Nandy S, Wang M, Araujo LT, Ryu D, Holler C, Thompson BM, Astarita G, Blain JF, Kukar T.
Cell Rep. 2024 Nov 19;43(12):114985. doi: 10.1016/j.celrep.2024.114985.
PubMed
Associated Plasmids |
| An ADPRS variant disrupts ARH3 stability and subcellular localization in children with neurodegeneration and respiratory failure. Bannister M, Bray S, Aggarwal A, Billington C Jr, Nguyen HD. HGG Adv. 2025 Jan 9;6(1):100386. doi: 10.1016/j.xhgg.2024.100386. Epub 2024 Nov 22. PubMed |
| Suppression of ADP-ribosylation reversal triggers cell vulnerability to alkylating agents. Caggiano R, Prokhorova E, Duma L, Schutzenhofer K, Lauro R, Catara G, Melillo RM, Celetti A, Smith R, Weroha SJ, Kaufmann SH, Ahel I, Palazzo L. Neoplasia. 2025 Jan;59:101092. doi: 10.1016/j.neo.2024.101092. Epub 2024 Nov 29. PubMed |
| Repurposing of lonafarnib as a treatment for SARS-CoV-2 infection. Khan M, Irvin P, Park SB, Ivester HM, Ricardo-Lax I, Leek M, Grieshaber A, Jang ES, Coutermarsh-Ott S, Zhang Q, Maio N, Jiang JK, Li B, Huang W, Wang AQ, Xu X, Hu Z, Zheng W, Ye Y, Rouault T, Rice C, Allen IC, Liang TJ. JCI Insight. 2025 Jan 9;10(1):e182704. doi: 10.1172/jci.insight.182704. PubMed |
| Widespread neuroanatomical integration and distinct electrophysiological properties of glioma-innervating neurons. Hsieh AL, Ganesh S, Kula T, Irshad M, Ferenczi EA, Wang W, Chen YC, Hu SH, Li Z, Joshi S, Haigis MC, Sabatini BL. Proc Natl Acad Sci U S A. 2024 Dec 10;121(50):e2417420121. doi: 10.1073/pnas.2417420121. Epub 2024 Dec 4. PubMed |
| Missense Mutant p53 Transactivates Wnt/beta-Catenin Signaling in Neighboring p53-Destabilized Cells through the COX-2/PGE2 Pathway. Nakayama M, Saito H, Murakami K, Oshima H, Oshima M. Cancer Res Commun. 2025 Jan 1;5(1):13-23. doi: 10.1158/2767-9764.CRC-24-0471. PubMed |
Classification and functional characterization of regulators of intracellular STING trafficking identified by genome-wide optical pooled screening.
Gentili M, Carlson RJ, Liu B, Hellier Q, Andrews J, Qin Y, Blainey PC, Hacohen N.
Cell Syst. 2024 Dec 18;15(12):1264-1277.e8. doi: 10.1016/j.cels.2024.11.004. Epub 2024 Dec 9.
PubMed
Associated Plasmids |
SARS-CoV-2 3CL(pro) (main protease) regulates caspase activation of gasdermin-D/E pores leading to secretion and extracellular activity of 3CL(pro).
Grin PM, Baid K, de Jesus HCR, Kozarac N, Bell PA, Jiang SZ, Kappelhoff R, Butler GS, Leborgne NGF, Pan C, Pablos I, Machado Y, Vederas JC, Kim H, Benarafa C, Banerjee A, Overall CM.
Cell Rep. 2024 Dec 24;43(12):115080. doi: 10.1016/j.celrep.2024.115080. Epub 2024 Dec 12.
PubMed
Associated Plasmids |
| Plasticity of Human Microglia and Brain Perivascular Macrophages in Aging and Alzheimer's Disease. Lee D, Vicari JM, Porras C, Spencer C, Pjanic M, Wang X, Kinrot S, Weiler P, Kosoy R, Bendl J, Prashant NM, Psychogyiou K, Malakates P, Hennigan E, Monteiro Fortes J, Zheng S, Therrien K, Mathur D, Kleopoulos SP, Shao Z, Argyriou S, Alvia M, Casey C, Hong A, Beaumont KG, Sebra R, Kellner CP, Bennett DA, Yuan GC, Voloudakis G, Theis FJ, Haroutunian V, Hoffman GE, Fullard JF, Roussos P. medRxiv [Preprint]. 2024 Dec 5:2023.10.25.23297558. doi: 10.1101/2023.10.25.23297558. PubMed |
| CD38 Inhibitor 78c Attenuates Pro-Inflammatory Cytokine Expression and Osteoclastogenesis in Macrophages. Lory W, Chowdhury N, Wellslager B, Pandruvada S, Huang Y, Yilmaz O, Yu H. Cells. 2024 Nov 28;13(23):1971. doi: 10.3390/cells13231971. PubMed |
| Bat RNA viruses employ viral RHIMs orchestrating species-specific cell death programs linked to Z-RNA sensing and ZBP1-RIPK3 signaling. Mishra S, Jain D, Dey AA, Nagaraja S, Srivastava M, Khatun O, Balamurugan K, Anand M, Ashok AK, Tripathi S, Ganji M, Kesavardhana S. iScience. 2024 Nov 20;27(12):111444. doi: 10.1016/j.isci.2024.111444. eCollection 2024 Dec 20. PubMed |
| Calceolarioside B inhibits SARS-CoV-2 Omicron BA.2 variant cell entry and modulates immune response. Lin XB, Yao YZ, Wen QR, Liu FB, Cai YX, Chen RH, Han J. Virol J. 2024 Dec 21;21(1):329. doi: 10.1186/s12985-024-02566-w. PubMed |
| Glutathione peroxidase 4 overexpression induces anomalous subdiffusion and impairs glioblastoma cell growth. Teferi N, Ekanayake A, Owusu SB, Moninger TO, Sarkaria JN, Tivanski AV, Petronek MS. J Biol Eng. 2024 Dec 21;18(1):72. doi: 10.1186/s13036-024-00472-x. PubMed |
| Co-essentiality analysis identifies PRR12 as a cohesin interacting protein and contributor to genomic integrity. Nguyen AL, Smith EM, Cheeseman IM. Dev Cell. 2025 Apr 21;60(8):1217-1233.e7. doi: 10.1016/j.devcel.2024.12.015. Epub 2024 Dec 31. PubMed |
| Viral oncogene EBNALP regulates YY1 DNA binding and alters host 3D genome organization. Wang C, Leong MM, Ding W, Narita Y, Liu X, Wang H, Yiu SPT, Lee J, Zhao KRS, Cui A, Gewurz B, Hammerschmidt W, Teng M, Zhao B. EMBO Rep. 2025 Feb;26(3):810-835. doi: 10.1038/s44319-024-00357-6. Epub 2025 Jan 2. PubMed |
| PlexinD1 is a driver and a therapeutic target in advanced prostate cancer. Wei J, Wang J, Guan W, Li J, Pu T, Corey E, Lin TP, Gao AC, Wu BJ. EMBO Mol Med. 2025 Feb;17(2):336-364. doi: 10.1038/s44321-024-00186-z. Epub 2025 Jan 2. PubMed |
| Systematic functional characterization of non-coding regulatory SNPs associated with central obesity. Dong SS, Duan YY, Zhu RJ, Jia YY, Chen JX, Huang XT, Tang SH, Yu K, Shi W, Chen XF, Jiang F, Hao RH, Liu Y, Liu Z, Guo Y, Yang TL. Am J Hum Genet. 2025 Jan 2;112(1):116-134. doi: 10.1016/j.ajhg.2024.11.005. PubMed |
| MTCH2 controls energy demand and expenditure to fuel anabolism during adipogenesis. Chourasia S, Petucci C, Shoffler C, Abbasian D, Wang H, Han X, Sivan E, Brandis A, Mehlman T, Malitsky S, Itkin M, Sharp A, Rotkopf R, Dassa B, Regev L, Zaltsman Y, Gross A. EMBO J. 2025 Feb;44(4):1007-1038. doi: 10.1038/s44318-024-00335-7. Epub 2025 Jan 3. PubMed |
| RACK1 MARylation regulates translation and stress granules in ovarian cancer cells. Challa S, Nandu T, Kim HB, Gong X, Renshaw CW, Li WC, Tan X, Aljardali MW, Camacho CV, Chen J, Kraus WL. J Cell Biol. 2025 Feb 3;224(2):e202401101. doi: 10.1083/jcb.202401101. Epub 2025 Jan 6. PubMed |
| Inhibition of GSK3beta is synthetic lethal with FHIT loss in lung cancer by blocking homologous recombination repair. Tao S, Pu Y, Yang EJ, Ren G, Shi C, Chen LJ, Chen L, Shim JS. Exp Mol Med. 2025 Feb;57(1):167-183. doi: 10.1038/s12276-024-01374-0. Epub 2025 Jan 6. PubMed |
| HCMV infection downregulates GPX4 and stimulates lipid peroxidation but does not induce ferroptosis. Martin M, Kumar R, Buchkovich NJ, Norbury CC. J Virol. 2025 Feb 25;99(2):e0185124. doi: 10.1128/jvi.01851-24. Epub 2025 Jan 7. PubMed |
| NAC regulates metabolism and cell fate in intestinal stem cells. Ramalho S, Alkan F, Prekovic S, Jastrzebski K, Barbera EP, Hoekman L, Altelaar M, de Heus C, Liv N, Rodriguez-Colman MJ, Yilmaz M, van der Kammen R, Fedry J, de Gooijer MC, Suijkerbuijk SJE, Faller WJ, Silva J. Sci Adv. 2025 Jan 10;11(2):eadn9750. doi: 10.1126/sciadv.adn9750. Epub 2025 Jan 8. PubMed |
| Inosine monophosphate dehydrogenase 2 (IMPDH2) modulates response to therapy and chemo-resistance in triple negative breast cancer. da Silva Fernandes T, Gillard BM, Dai T, Martin JC, Chaudhry KA, Dugas SM, Fisher AA, Sharma P, Wu R, Attwood KM, Dasgupta S, Takabe K, Rosario SR, Bianchi-Smiraglia A. Sci Rep. 2025 Jan 7;15(1):1061. doi: 10.1038/s41598-024-85094-5. PubMed |
| CD4+ T helper 2 cell-macrophage crosstalk induces IL-24-mediated breast cancer suppression. Wang B, Xia Y, Zhou C, Zeng Y, Son HG, Demehri S. JCI Insight. 2025 Jan 9;10(1):e180962. doi: 10.1172/jci.insight.180962. PubMed |
| Oncolytic viruses expressing MATEs facilitate target-independent T-cell activation in tumors. Peter M, Mundt B, Menze A, Woller N, Volk V, Ernst AM, Ohler LA, Talbot SR, Wedemeyer H, Falk C, Feuerhake F, Wirth TC, Kuhnel F. EMBO Mol Med. 2025 Feb;17(2):265-300. doi: 10.1038/s44321-024-00187-y. Epub 2025 Jan 9. PubMed |
| Nuclear N-WASP Induces Actin Polymerization in the Nucleus with Cortactin as an Essential Factor. Jiang X, Mohapatra P, Rossing M, Zheng W, Zbodakova O, Thatte JV, Sorensen CS, Le Phan TH, Brakebusch C. Cells. 2025 Jan 6;14(1):59. doi: 10.3390/cells14010059. PubMed |
| In-depth inference of transcriptional regulatory networks reveals NPM1 as a therapeutic ribosomal regulator in MYC-amplified medulloblastoma. Chen T, Chen H, Xia M, Liao Y, Li H, Dong X, Lin Y, Zhou W. NPJ Precis Oncol. 2025 Jan 10;9(1):10. doi: 10.1038/s41698-024-00792-7. PubMed |
| Anatomical, subset, and HIV-dependent expression of viral sensors and restriction factors. George AF, Neidleman J, Luo X, Frouard J, Elphick N, Yin K, Young KC, Ma T, Andrew AK, Ezeonwumelu IJ, Pedersen JG, Chaillon A, Porrachia M, Woodworth B, Jakobsen MR, Thomas R, Smith DM, Gianella S, Roan NR. Cell Rep. 2025 Jan 28;44(1):115202. doi: 10.1016/j.celrep.2024.115202. Epub 2025 Jan 10. PubMed |
| Deletion of AMP-activated protein kinase impairs metastasis and is rescued by ROS scavenging or ectopic CD36 expression. Ramakrishnan G, Terry AR, Nogueira V, Magdy A, Hay N. Cell Rep. 2025 Jan 28;44(1):115183. doi: 10.1016/j.celrep.2024.115183. Epub 2025 Jan 10. PubMed |
| MFSD6 is an entry receptor for respiratory enterovirus D68. Liu X, Li H, Li Z, Gao D, Zhou J, Ni F, Yu Q, Huang Y, Tang Y, Xue L, Wang S, Yang J, Guo H, Wang Y, Yu XF, Yu Z, Wei W. Cell Host Microbe. 2025 Feb 12;33(2):267-278.e4. doi: 10.1016/j.chom.2024.12.015. Epub 2025 Jan 10. PubMed |
| Transcription factor EB (TFEB) activity increases resistance of TNBC stem cells to metabolic stress. Soleimani M, Duchow M, Goyal R, Somma A, Kaoud TS, Dalby KN, Kowalski J, Eckhardt SG, Van Den Berg C. Life Sci Alliance. 2025 Jan 15;8(3):e202302259. doi: 10.26508/lsa.202302259. Print 2025 Mar. PubMed |
| A thermoplastic chip for 2D and 3D correlative assays combining screening and high-resolution imaging of immune cell responses. van Ooijen H, Verron Q, Zhang H, Sandoz PA, Frisk TW, Carannante V, Olofsson K, Wagner AK, Sandstrom N, Onfelt B. Cell Rep Methods. 2025 Jan 27;5(1):100965. doi: 10.1016/j.crmeth.2025.100965. Epub 2025 Jan 17. PubMed |
| Loss of SMAD1 in acute myeloid leukemia with KMT2A::AFF1 and KMT2A::MLLT3 fusion genes. Dietsche L, Stirm K, Lysenko V, Schneidawind C, Tzankov A, Muller A, Theocharides APA. Front Oncol. 2025 Jan 6;14:1481713. doi: 10.3389/fonc.2024.1481713. eCollection 2024. PubMed |
| Mechanical Strain of Corneal Epithelium Influences the Expression of Genes Implicated in Keratoconus. Moon L, Kaur P, Wang J, Sodhi A, Eberhart C, Soiberman U. Invest Ophthalmol Vis Sci. 2025 Jan 2;66(1):52. doi: 10.1167/iovs.66.1.52. PubMed |
| Co-option of mitochondrial nucleic acid-sensing pathways by HSV-1 UL12.5 for reactivation from latent infection. Krakowiak PA, Flores ME, Cuddy SR, Whitford AL, Dochnal SA, Babnis A, Miyake T, Tigano M, Engel DA, Cliffe AR. Proc Natl Acad Sci U S A. 2025 Jan 28;122(4):e2413965122. doi: 10.1073/pnas.2413965122. Epub 2025 Jan 24. PubMed |
| SLC25A38 is required for mitochondrial pyridoxal 5'-phosphate (PLP) accumulation. Pena IA, Shi JS, Chang SM, Yang J, Block S, Adelmann CH, Keys HR, Ge P, Bathla S, Witham IH, Sienski G, Nairn AC, Sabatini DM, Lewis CA, Kory N, Vander Heiden MG, Heiman M. Nat Commun. 2025 Jan 24;16(1):978. doi: 10.1038/s41467-025-56130-3. PubMed |
| Rab10-associated tubulation as an early marker for biogenesis of the assembly compartment in cytomegalovirus-infected cells. Mahmutefendic Lucin H, Stimac I, Marcelic M, Skocaj M, Lisnic B, Omerovic A, Viduka I, Radic B, Karleusa L, Blagojevic Zagorac G, Dezeljin M, Jurak Begonja A, Lucin P. Front Cell Dev Biol. 2025 Jan 10;12:1517236. doi: 10.3389/fcell.2024.1517236. eCollection 2024. PubMed |
| Development of chimeric antigen receptor T cells targeting cancer-expressing podocalyxin. Mishima Y, Okada S, Ishikawa A, Wang B, Waseda M, Kaneko MK, Kato Y, Kaneko S. Regen Ther. 2025 Jan 4;28:292-300. doi: 10.1016/j.reth.2024.12.010. eCollection 2025 Mar. PubMed |
Cell-free assays reveal that the HIV-1 capsid protects reverse transcripts from cGAS immune sensing.
Scott TM, Arnold LM, Powers JA, McCann DA, Rowe AB, Christensen DE, Pereira MJ, Zhou W, Torrez RM, Iwasa JH, Kranzusch PJ, Sundquist WI, Johnson JS.
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PubMed
Associated Plasmids |
| The Histone Demethylase LSD1/ZNF217/CoREST Complex is a Major Restriction Factor of Epstein-Barr Virus Lytic Reactivation. Liao Y, Yan J, Kong I, Li Z, Ding W, Clark S, Giulino-Roth L, Gewurz BE. Res Sq [Preprint]. 2025 Jan 13:rs.3.rs-5649616. doi: 10.21203/rs.3.rs-5649616/v1. PubMed |
| Establishment of a human ovarian endometrioid carcinoma cell line by constitutive expression of cyclin-dependent kinase 4, cyclin D1 and telomerase reverse transcriptase. Hoshino H, Akama TO, Inoue D, Moritani S, Shigeto S, Matsuda K, Yoshida H, Yonemoto N, Fukushima M, Yoshida Y, Kobayashi M. Hum Cell. 2025 Jan 29;38(2):47. doi: 10.1007/s13577-025-01176-0. PubMed |
| A hierarchical pathway for assembly of the distal appendages that organize primary cilia. Kanie T, Liu B, Love JF, Fisher SD, Gustavsson AK, Jackson PK. Elife. 2025 Jan 30;14:e85999. doi: 10.7554/eLife.85999. PubMed |
| Myristoylated Neuronal Calcium Sensor-1 captures the preciliary vesicle at distal appendages. Kanie T, Ng R, Abbott KL, Tanvir NM, Lorentzen E, Pongs O, Jackson PK. Elife. 2025 Jan 30;14:e85998. doi: 10.7554/eLife.85998. PubMed |
| Pharmacological ascorbate combined with rucosopasem selectively radio-chemo-sensitizes NSCLC via generation of H(2)O(2). Pulliam CF, Fath MA, Sho S, Johnson ST, Wagner BA, Singhania M, Kalen AL, Bayanbold K, Solst SR, Allen BG, George BN, Caster JM, Buettner GR, Riley DP, Keene JL, Beardsley RA, Spitz DR. Redox Biol. 2025 Mar;80:103505. doi: 10.1016/j.redox.2025.103505. Epub 2025 Jan 23. PubMed |
| Targeting ABCD1-ACOX1-MET/IGF1R axis suppresses multiple myeloma. Han Z, Yan Z, Ma Z, Wang Y, Beus M, Lu J, Weidenhammer LB, Lakhani K, Lee J, Civils JD, Furdui CM, Liu L, Wu J, Kang Y, Bieberich E, Boise LH, Nikiforov MA. Leukemia. 2025 Mar;39(3):720-733. doi: 10.1038/s41375-025-02522-9. Epub 2025 Jan 30. PubMed |
| IRS2 as a driver of brain metastasis in colorectal cancer: A potential target for novel therapeutic strategies. Greenberg I, Khair-Dabour F, Merenbakh-Lamin K, Sokol ES, Goldberg AK, Simkin D, Spitzer A, Benhamou M, Bar-Shira S, Raz M, Grossman R, Yeini E, Ofek P, Meirson T, Satchi-Fainaro R, Reuveni H, Wolf I, Rubinek T. Neuro Oncol. 2025 Sep 8;27(7):1729-1745. doi: 10.1093/neuonc/noaf028. PubMed |
| Genetically Defined Organoid Models Reveal Mechanisms Driving Squamous Cell Neoplastic Evolution and Identify Potential Therapeutic Vulnerabilities. Zhao H, Park YM, Zheng Y, Mao Q, Collet C, Hu B, Zhou T, Lin L, Wong S, Pan Y, Monreal AV, Sinha UK, Sedghizadeh P, Soragni A, Lin DC. bioRxiv [Preprint]. 2025 Jan 22:2025.01.18.631624. doi: 10.1101/2025.01.18.631624. PubMed |
| The E2F4 transcriptional repressor is a key mechanistic regulator of colon cancer resistance to irinotecan (CPT-11). Matsubara J, Li YF, Koul S, Mukohyama J, Salazar LEV, Isobe T, Qian D, Clarke MF, Sahoo D, Altman RB, Dalerba P. bioRxiv [Preprint]. 2025 Jan 24:2025.01.22.633435. doi: 10.1101/2025.01.22.633435. PubMed |
| Multi-locus CRISPRi targeting with a single truncated guide RNA. Moore MM, Wekhande S, Issner R, Collins A, Cruz AJ, Liu YV, Javed N, Casani-Galdon S, Buenrostro JD, Epstein CB, Mattei E, Doench JG, Bernstein BE, Shoresh N, Najm FJ. Nat Commun. 2025 Feb 4;16(1):1357. doi: 10.1038/s41467-025-56144-x. PubMed |
| Combinatorial In Vivo Genome Editing Identifies Widespread Epistasis and an Accessible Fitness Landscape During Lung Tumorigenesis. Hebert JD, Tang YJ, Szamecz M, Andrejka L, Lopez SS, Petrov DA, Boross G, Winslow MM. Mol Biol Evol. 2025 Feb 3;42(2):msaf023. doi: 10.1093/molbev/msaf023. PubMed |
Characterization and bioinformatic filtering of ambient gRNAs in single-cell CRISPR screens using CLEANSER.
Liu S, Hamilton MC, Cowart T, Barrera A, Bounds LR, Nelson AC, Dornbaum SF, Riley JW, Doty RW, Allen AS, Crawford GE, Majoros WH, Gersbach CA.
Cell Genom. 2025 Feb 4:100766. doi: 10.1016/j.xgen.2025.100766.
PubMed
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| Combined inhibition of focal adhesion kinase and RAF/MEK elicits synergistic inhibition of melanoma growth and reduces metastases. Almazan J, Turapov T, Kircher DA, Stanley KA, Culver K, Medellin AP, Field MN, Parkman GL, Colman H, Coma S, Pachter JA, Holmen SL. Cell Rep Med. 2025 Feb 18;6(2):101943. doi: 10.1016/j.xcrm.2025.101943. Epub 2025 Feb 7. PubMed |
| KSR1 Mediates Small Cell Lung Carcinoma Tumor Initiation and Cisplatin Resistance. Chatterjee D, Svoboda RA, Huisman DH, Drapkin BJ, Vieira HM, Rao C, Askew JW, Fisher KW, Lewis RE. Mol Cancer Res. 2025 Jun 3;23(6):553-566. doi: 10.1158/1541-7786.MCR-24-0652. PubMed |
| A CRISPR-Cas9 screen reveals genetic determinants of the cellular response to decitabine. Zhang P, Zhang Z, Wang Y, Du W, Song X, Lai W, Wang H, Zhu B, Xiong J. EMBO Rep. 2025 Mar;26(6):1528-1565. doi: 10.1038/s44319-025-00385-w. Epub 2025 Feb 10. PubMed |
| Aberrant expression of GTPase-activating protein ARAP1 triggers circular dorsal ruffles associated with malignancy in hepatocellular carcinoma Hep3B cells. Sun X, Li Y, He Y, Cheng L, Wang L, Wei J, Chen J, Du L, Shen Z, Xie Y, Midgley AC, Jiang W, Yoshida S. Cell Commun Signal. 2025 Feb 11;23(1):75. doi: 10.1186/s12964-025-02084-4. PubMed |
| UM171 glues asymmetric CRL3-HDAC1/2 assembly to degrade CoREST corepressors. Yeo MJR, Zhang O, Xie X, Nam E, Payne NC, Gosavi PM, Kwok HS, Iram I, Lee C, Li J, Chen NJ, Nguyen K, Jiang H, Wang ZA, Lee K, Mao H, Harry SA, Barakat IA, Takahashi M, Waterbury AL, Barone M, Mattevi A, Carr SA, Udeshi ND, Bar-Peled L, Cole PA, Mazitschek R, Liau BB, Zheng N. Nature. 2025 Mar;639(8053):232-240. doi: 10.1038/s41586-024-08532-4. Epub 2025 Feb 12. PubMed |
| Converging mechanism of UM171 and KBTBD4 neomorphic cancer mutations. Xie X, Zhang O, Yeo MJR, Lee C, Tao R, Harry SA, Payne NC, Nam E, Paul L, Li Y, Kwok HS, Jiang H, Mao H, Hadley JL, Lin H, Batts M, Gosavi PM, D'Angiolella V, Cole PA, Mazitschek R, Northcott PA, Zheng N, Liau BB. Nature. 2025 Mar;639(8053):241-249. doi: 10.1038/s41586-024-08533-3. Epub 2025 Feb 12. PubMed |
| Dissecting the Spatial and Single-Cell Transcriptomic Architecture of Cancer Stem Cell Niche Driving Tumor Progression in Gastric Cancer. Zhang G, Zhang X, Pan W, Chen X, Wan L, Liu C, Yong Y, Zhao Y, Sang S, Zhang L, Yao S, Guo Y, Wang M, Wang X, Peng G, Yan X, Wang Y, Zhang M. Adv Sci (Weinh). 2025 May;12(18):e2413019. doi: 10.1002/advs.202413019. Epub 2025 Feb 14. PubMed |
| Inhibition of the Integrated stress response by Epstein-Barr virus oncoprotein LMP1 attenuates epithelial cell differentiation and lytic viral reactivation. Singh DR, Zhang Y, White SJ, Nelson SE, Fogarty SA, Pawelski AS, Kansra AS, Kenney SC. PLoS Pathog. 2025 Feb 14;21(2):e1012934. doi: 10.1371/journal.ppat.1012934. eCollection 2025 Feb. PubMed |
| Lysosomal NKG7 restrains mTORC1 activity to promote CD8(+) T cell durability and tumor control. Ham H, Hirdler JB, Bihnam DT, Mao Z, Gicobi JK, Macedo BG, Rodriguez-Quevedo MF, Schultz DF, Correia C, Zhong J, Martinez KE, Banuelos A, Ashton DS, Lagnado AB, Guo R, Pessoa R, Pandey A, Li H, Lucien F, Borges da Silva H, Dong H, Billadeau DD. Nat Commun. 2025 Feb 14;16(1):1628. doi: 10.1038/s41467-025-56931-6. PubMed |
| CRISPR screening identifies regulators of enhancer-mediated androgen receptor transcription in advanced prostate cancer. Xiang RR, Lee SA, Tyndall CF, Bhatia AR, Yin J, Singler C, Hauk BJ, Kipp MP, Takeda DY. Cell Rep. 2025 Feb 25;44(2):115312. doi: 10.1016/j.celrep.2025.115312. Epub 2025 Feb 14. PubMed |
| The CXCL8/MAPK/hnRNP-K axis enables susceptibility to infection by EV-D68, rhinovirus, and influenza virus in vitro. Yang Q, Guo H, Li H, Li Z, Ni F, Wen Z, Liu K, Kong H, Wei W. Nat Commun. 2025 Feb 17;16(1):1715. doi: 10.1038/s41467-025-57094-0. PubMed |
| Role of androgen receptors in sexually dimorphic phenotypes in UBE3A-dependent autism spectrum disorder. Tian Y, Qiao H, Odamah K, Zhu LQ, Man HY. iScience. 2025 Jan 22;28(2):111868. doi: 10.1016/j.isci.2025.111868. eCollection 2025 Feb 21. PubMed |
| Nuclear stiffness through lamin A/C overexpression differentially modulates chromosomal instability biomarkers. Bosch-Calvet M, Perez-Venteo A, Cebria-Xart A, Garcia-Cajide M, Mauvezin C. Biol Cell. 2025 Feb;117(2):e12001. doi: 10.1111/boc.12001. PubMed |
| Serotonergic Psychedelics Rapidly Modulate Evoked Glutamate Release in Cultured Cortical Neurons. Petruskova A, Guhathakurta D, Akdas EY, Perello-Amoros B, Frischknecht R, Weiss EM, Palenicek T, Fejtova A. J Neurochem. 2025 Mar;169(3):e70020. doi: 10.1111/jnc.70020. PubMed |
| CHIP protects lysosomes from CLN4 mutant-induced membrane damages. Lee J, Zou J, Binti Mazli WNA, Chin N, Jarnik M, Saidi L, Xu Y, Replogle J, Ward M, Bonifacino J, Zheng W, Hao L, Ye Y. bioRxiv [Preprint]. 2025 Feb 19:2025.02.18.638932. doi: 10.1101/2025.02.18.638932. PubMed |
| EGFR-induced lncRNA TRIDENT promotes drug resistance in non-small cell lung cancer via phospho-TRIM28-mediated DNA damage repair. Saxena T, Quan A, Chan E, Kozlova N, Matai L, Lee JD, Rupaimoole R, Beca F, Muranen T, Slack FJ. Proc Natl Acad Sci U S A. 2025 Mar 11;122(10):e2415389122. doi: 10.1073/pnas.2415389122. Epub 2025 Mar 3. PubMed |
| Proximity proteomics reveals a mechanism of fatty acid transfer at lipid droplet-mitochondria- endoplasmic reticulum contact sites. Bezawork-Geleta A, Devereux CJ, Keenan SN, Lou J, Cho E, Nie S, De Souza DP, Narayana VK, Siddall NA, Rodrigues CHM, Portelli S, Zheng T, Nim HT, Ramialison M, Hime GR, Dodd GT, Hinde E, Ascher DB, Stroud DA, Watt MJ. Nat Commun. 2025 Mar 3;16(1):2135. doi: 10.1038/s41467-025-57405-5. PubMed |
| Packaged delivery of CRISPR-Cas9 ribonucleoproteins accelerates genome editing. Karp H, Zoltek M, Wasko K, Vazquez AL, Brim J, Ngo W, Schepartz A, Doudna JA. Nucleic Acids Res. 2025 Feb 27;53(5):gkaf105. doi: 10.1093/nar/gkaf105. PubMed |
| Differential regulation of BAX and BAK apoptotic activity revealed by small molecules. Li K, Yap YQ, Moujalled DM, Sumardy F, Khakham Y, Georgiou A, Jahja M, Lew TE, De Silva M, Luo MX, Gong JN, Yuan Z, Birkinshaw RW, Czabotar PE, Lowes K, Huang DCS, Kile BT, Wei AH, Dewson G, van Delft MF, Lessene G. Sci Adv. 2025 Mar 7;11(10):eadr8146. doi: 10.1126/sciadv.adr8146. Epub 2025 Mar 5. PubMed |
| Structure-function relationship of ASH1L and histone H3K36 and H3K4 methylation. Vann KR, Sharma R, Hsu CC, Devoucoux M, Tencer AH, Zeng L, Lin K, Zhu L, Li Q, Lachance C, Ospina RR, Tong Q, Cheung KL, Yang S, Biswas S, Xuan H, Gatchalian J, Alamillo L, Wang J, Jang SM, Klein BJ, Lu Y, Ernst P, Strahl BD, Rothbart SB, Walsh MJ, Cleary ML, Cote J, Shi X, Zhou MM, Kutateladze TG. Nat Commun. 2025 Mar 6;16(1):2235. doi: 10.1038/s41467-025-57556-5. PubMed |
| The TCF4 Gene Regulates Apoptosis of Corneal Endothelial Cells in Fuchs Endothelial Corneal Dystrophy. Nakagawa T, Honda T, Yuasa T, Nishiuchi G, Sato M, Tokunaga A, Nakahara M, Tourtas T, Schlotzer-Schrehardt U, Kruse F, Padmanabhan P, Chatterjee A, Sathe G, Ghose V, Janakiraman N, Blake DJ, Koizumi N, Elchuri S, Okumura N. Invest Ophthalmol Vis Sci. 2025 Mar 3;66(3):16. doi: 10.1167/iovs.66.3.16. PubMed |
| Coupling Proximity Biotinylation with Genomic Targeting to Characterize Locus-Specific Changes in Chromatin Environments. Kougnassoukou Tchara PE, Loehr J, Lambert JP. J Proteome Res. 2025 Apr 4;24(4):1845-1860. doi: 10.1021/acs.jproteome.4c00931. Epub 2025 Mar 7. PubMed |
| Human memory CD4(+) T-cells recognize Mycobacterium tuberculosis-infected macrophages amid broader pathogen-specific responses. Stetsenko V, Gail DP, Reba S, Suzart VG, Sandhu AK, Sette A, Dezfulian MH, Arlehamn CSL, Carpenter SM. bioRxiv [Preprint]. 2025 Feb 27:2025.02.23.639515. doi: 10.1101/2025.02.23.639515. PubMed |
| Subcellular proteomics and iPSC modeling uncover reversible mechanisms of axonal pathology in Alzheimer's disease. Cai Y, Kanyo J, Wilson R, Bathla S, Cardozo PL, Tong L, Qin S, Fuentes LA, Pinheiro-de-Sousa I, Huynh T, Sun L, Mansuri MS, Tian Z, Gan HR, Braker A, Trinh HK, Huttner A, Lam TT, Petsalaki E, Brennand KJ, Nairn AC, Grutzendler J. Nat Aging. 2025 Mar;5(3):504-527. doi: 10.1038/s43587-025-00823-3. Epub 2025 Mar 10. PubMed |
| miR-204-5p Protects Nephrin from Enzymatic Degradation in Cultured Mouse Podocytes Treated with Nephrotoxic Serum. Haddad G, Blaine J. Cells. 2025 Mar 1;14(5):364. doi: 10.3390/cells14050364. PubMed |
| KLF family members control expression of genes required for tissue macrophage identities. Pestal K, Slayden LC, Barton GM. J Exp Med. 2025 May 5;222(5):e20240379. doi: 10.1084/jem.20240379. Epub 2025 Mar 12. PubMed |
| Both direct and indirect suppression of MCL1 synergizes with BCLXL inhibition in preclinical models of gastric cancer. Zhang LP, Wei YM, Luo MJ, Ren SY, Zhan XW, Wang C, Li ZF, Zhu RM, Yan S, Cheng Y, Xu JL, Yang XJ, Du KL, Wang JQ, Zhang GN, Du DX, Gao R, Zhao DB, Gong JN. Cell Death Dis. 2025 Mar 12;16(1):170. doi: 10.1038/s41419-025-07481-8. PubMed |
| The Selective 3-MST Inhibitor I3MT-3 Works as a Potent Caspase-1 Inhibitor. Otani K, Komatsu R, Noguchi T, Suzuki W, Hirata Y, Matsuzawa A. Int J Mol Sci. 2025 Mar 2;26(5):2237. doi: 10.3390/ijms26052237. PubMed |
| Suppression of Hepatocellular Carcinoma by Deletion of SIRT2 in Hepatocytes via Elevated C/EBPbeta/GADD45gamma. Wang F, Keating CR, Xu Y, Hou W, Malnassy G, Boedeker K, Perera A, Ham E, Patel D, Ding X, Qiu W. Cell Mol Gastroenterol Hepatol. 2025;19(7):101494. doi: 10.1016/j.jcmgh.2025.101494. Epub 2025 Mar 11. PubMed |
| Genome-wide screening in human embryonic stem cells identifies genes and pathways involved in the p53 pathway. Haddad A, Golan-Lev T, Benvenisty N, Goldberg M. Mol Med. 2025 Mar 13;31(1):97. doi: 10.1186/s10020-025-01141-5. PubMed |
| QRICH1 mediates an intracellular checkpoint for CD8(+) T cell activation via the CARD11 signalosome. Carter NM, Hankore WD, Yang YK, Yang C, Hutcherson SM, Fales W, Ghosh A, Mongia P, Mackinnon S, Brennan A, Leone RD, Pomerantz JL. Sci Immunol. 2025 Mar 14;10(105):eadn8715. doi: 10.1126/sciimmunol.adn8715. Epub 2025 Mar 14. PubMed |
| Heat shock protein family D member 1 mediates lung cancer cell‑induced angiogenesis of endothelial cells. Somsuan K, Rongjumnong A, Morchang A, Hankittichai P, Ngoenkam J, Makeudom A, Lirdprapamongkol K, Krisanaprakornkit S, Pongcharoen S, Svasti J, Aluksanasuwan S. Biomed Rep. 2025 Feb 27;22(5):77. doi: 10.3892/br.2025.1955. eCollection 2025 May. PubMed |
| A CPC-shelterin-BTR axis regulates mitotic telomere deprotection. Romero-Zamora D, Rogers S, Low RRJ, Page SG, Lane BJE, Kosaka S, Robinson AB, French L, Lamm N, Ishikawa F, Hayashi MT, Cesare AJ. Nat Commun. 2025 Mar 17;16(1):2277. doi: 10.1038/s41467-025-57456-8. PubMed |
| METTL3-mediated m (6)A modification of pri-miRNA-31 promotes hypertrophic scar progression. Wang Q, Hou J, Zeng S, Wang X, Liang Y, Zhou R. Acta Biochim Biophys Sin (Shanghai). 2025 Mar 18;57(7):1106-1114. doi: 10.3724/abbs.2025033. PubMed |
| Elevated VRK1 levels after androgen deprivation therapy promote prostate cancer progression by upregulating YAP1 expression. Meng Y, Ge J, Zhou C, Ma H, Chen C, Zhou Y, Hu X, Xu Y, Wang X, Shi G, Yu W, Zhang J. J Cancer Res Clin Oncol. 2025 Mar 20;151(3):116. doi: 10.1007/s00432-025-06168-z. PubMed |
| m(6)A deficiency impairs hypothalamic neurogenesis of feeding-related neurons in mice and human organoids and leads to adult obesity in mice. Shen Y, Wong SZH, Ma T, Zhang F, Wang Q, Kawaguchi R, Geschwind DH, Wang J, He C, Ming GL, Song H. Cell Stem Cell. 2025 May 1;32(5):727-743.e8. doi: 10.1016/j.stem.2025.02.011. Epub 2025 Mar 19. PubMed |
| A metabolic shift to the serine pathway induced by lipids fosters epigenetic reprogramming in nontransformed breast cells. Eduardo MB, Cottone G, McCloskey CW, Liu S, Palma FR, Zappia MP, Islam ABMMK, Gao P, Setya J, Dennis S, Gao H, Zhang Q, Xuei X, Luo Y, Locasale J, Bonini MG, Khokha R, Frolov MV, Benevolenskaya EV, Chandel NS, Khan SA, Clare SE. Sci Adv. 2025 Mar 21;11(12):eads9182. doi: 10.1126/sciadv.ads9182. Epub 2025 Mar 21. PubMed |
| Dicer deficiency affects microglial function during demyelination and impairs remyelination. Tripathi A, Rai NK, Perles A, Courtney H, Jones C, Sapra A, Plemel J, Dutta R. Neurobiol Dis. 2025 May;208:106879. doi: 10.1016/j.nbd.2025.106879. Epub 2025 Mar 20. PubMed |
| Depletion of tumor-derived CXCL5 improves T cell infiltration and anti-PD-1 therapy response in an obese model of pancreatic cancer. Walsh RM, Ambrose J, Jack JL, Eades AE, Bye BA, Tannus Ruckert M, Messaggio F, Olou AA, Chalise P, Pei D, VanSaun MN. J Immunother Cancer. 2025 Mar 22;13(3):e010057. doi: 10.1136/jitc-2024-010057. PubMed |
| A large-scale sORF screen identifies putative microproteins involved in cancer cell fitness. Schlesinger D, Dirks C, Navarro C, Lafranchi L, Spinner A, Raja GL, Mun-Sum Tong G, Eirich J, Martinez TF, Elsasser SJ. iScience. 2025 Jan 23;28(3):111884. doi: 10.1016/j.isci.2025.111884. eCollection 2025 Mar 21. PubMed |
| The ER-phagy receptor FAM134B is targeted by Salmonella Typhimurium to promote infection. Gatica D, Alsaadi RM, El Hamra R, Li B, Mueller R, Miyazaki M, Sun Q, Sad S, Russell RC. Nat Commun. 2025 Mar 25;16(1):2923. doi: 10.1038/s41467-025-58035-7. PubMed |
| Identification of a SNAI1 enhancer RNA that drives cancer cell plasticity. Fan C, Wang Q, Krijger PHL, Cats D, Selle M, Khorosjutina O, Dhanjal S, Schmierer B, Mei H, de Laat W, Ten Dijke P. Nat Commun. 2025 Mar 25;16(1):2890. doi: 10.1038/s41467-025-58032-w. PubMed |
| SCFA biotherapy delays diabetes in humanized gnotobiotic mice by remodeling mucosal homeostasis and metabolome. Tillett BJ, Dwiyanto J, Secombe KR, George T, Zhang V, Anderson D, Duggan E, Giri R, Loo D, Stoll T, Morrison M, Begun J, Hill MM, Gurzov EN, Bell KJ, Saad S, Barlow CK, Creek DJ, Chong CW, Marino E, Hamilton-Williams EE. Nat Commun. 2025 Mar 25;16(1):2893. doi: 10.1038/s41467-025-58319-y. PubMed |
| Reelin marks cocaine-activated striatal neurons, promotes neuronal excitability, and regulates cocaine reward. Brida KL, Jorgensen ET, Robert A Phillips Iii, Newman CE, Tuscher JJ, Morring EK, Zipperly ME, Ianov L, Montgomery KD, Tippani M, Hyde TM, Maynard KR, Martinowich K, Day JJ. Sci Adv. 2025 Mar 28;11(13):eads4441. doi: 10.1126/sciadv.ads4441. Epub 2025 Mar 26. PubMed |
| Amplified dosage of the NKX2-1 lineage transcription factor controls its oncogenic role in lung adenocarcinoma. Pulice JL, Meyerson M. Mol Cell. 2025 Apr 3;85(7):1311-1329.e16. doi: 10.1016/j.molcel.2025.03.001. Epub 2025 Mar 25. PubMed |
| ACVR2A attenuation impacts lactate production and hyperglycolytic conditions attracting regulatory T cells in hepatocellular carcinoma. Yasukawa K, Shimada S, Akiyama Y, Taniai T, Igarashi Y, Tsukihara S, Tanji Y, Umemura K, Kamachi A, Nara A, Yamane M, Akahoshi K, Shimizu A, Soejima Y, Tanabe M, Tanaka S. Cell Rep Med. 2025 Apr 15;6(4):102038. doi: 10.1016/j.xcrm.2025.102038. Epub 2025 Mar 25. PubMed |
| PAR(2) Serves an Indispensable Role in Controlling PAR(4) Oncogenicity: The beta-Catenin-p53 Axis. Appasamy P, Nag JK, Malka H, Bar-Shavit R. Int J Mol Sci. 2025 Mar 19;26(6):2780. doi: 10.3390/ijms26062780. PubMed |
| Adenine base editing with engineered virus-like particles rescues the CFTR mutation G542X in patient-derived intestinal organoids. Nicosia L, Pranke I, Latorre RV, Murray JB, Lonetti L, Cavusoglu-Doran K, Dreano E, Costello JP, Carroll M, Melotti P, Sorio C, Sermet-Gaudelus I, Scallan MF, Harrison PT. iScience. 2025 Feb 21;28(3):111979. doi: 10.1016/j.isci.2025.111979. eCollection 2025 Mar 21. PubMed |
| CD301b+ monocyte-derived dendritic cells mediate resistance to radiotherapy. Tadepalli S, Clements DR, Raquer-McKay HM, Ludtke A, Saravanan S, Seong D, Vitek L, Richards CM, Carette JE, Mack M, Gottfried-Blackmore A, Graves EE, Idoyaga J. J Exp Med. 2025 Jun 2;222(6):e20231717. doi: 10.1084/jem.20231717. Epub 2025 Mar 27. PubMed |
| Single-cell multi-omics analysis reveals the mechanism of action of a novel antioxidant polyphenol nanoparticle loaded with STAT3 agonist in mediating cardiomyocyte ferroptosis to ameliorate age-related heart failure. Zheng H, Tian Y, Li D, Liang Y. J Nanobiotechnology. 2025 Mar 29;23(1):258. doi: 10.1186/s12951-025-03317-x. PubMed |
| Oncogene-induced senescence mitochondrial metabolism and bioenergetics drive the secretory phenotype: further characterization and comparison with other senescence-inducing stimuli. Marmisolle I, Chacon E, Mansilla S, Ruiz S, Bresque M, Martinez J, Martinez-Zamudio RI, Herbig U, Liu J, Finkel T, Escande C, Castro L, Quijano C. Redox Biol. 2025 May;82:103606. doi: 10.1016/j.redox.2025.103606. Epub 2025 Mar 22. PubMed |
| The sperm quality in DIO male mice is linked to the NF-kappaB signaling and Ppp2ca expression in the hypothalamus. Feng X, Xu M, Liu Y, Wang X, Duan Y, Zheng X, Yin W, Cai Y, Zhang W, Jiang Q, Pang J, Li J. iScience. 2025 Feb 25;28(3):112110. doi: 10.1016/j.isci.2025.112110. eCollection 2025 Mar 21. PubMed |
| Siglec-15 is a putative receptor for porcine epidemic diarrhea virus infection. Feng Z, Fu Y, Yang S, Zhao H, Lin M, Liu C, Huang W, He X, Chen Y, Chen J, Shen Y, Li Z, Chen Q. Cell Mol Life Sci. 2025 Apr 2;82(1):136. doi: 10.1007/s00018-025-05672-2. PubMed |
| Covalent adduct Grob fragmentation underlies LSD1 demethylase-specific inhibitor mechanism of action and resistance. Waterbury AL, Caroli J, Zhang O, Tuttle PR, Liu C, Li J, Park JS, Hoenig SM, Barone M, Furui A, Mattevi A, Liau BB. Nat Commun. 2025 Apr 2;16(1):3156. doi: 10.1038/s41467-025-57477-3. PubMed |
| A High-Throughput, Three-Dimensional Multiple Myeloma Model Recapitulating Tumor-Stroma Interactions for CAR-Immune Cell-Mediated Cytotoxicity Assay. Luanpitpong S, Janan M, Poohadsuan J, Rodboon N, Samart P, Rungarunlert S, Issaragrisil S. Immunotargets Ther. 2025 Mar 30;14:321-338. doi: 10.2147/ITT.S503984. eCollection 2025. PubMed |
| RAF1 kinase contributes to autophagic lysosome reformation. Toifl S, Didusch S, Ehrenreiter K, Desideri E, Dorard C, Baccarini M. Cell Rep. 2025 Apr 22;44(4):115490. doi: 10.1016/j.celrep.2025.115490. Epub 2025 Apr 3. PubMed |
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| Nanoparticle-mediated sodium butyrate delivery for repairing hypoxic-ischemic brain injury in premature infants. Zhao J, Zhang J, Hou L, Yang C, Jiang L, Liang D. Mater Today Bio. 2025 Mar 14;32:101665. doi: 10.1016/j.mtbio.2025.101665. eCollection 2025 Jun. PubMed |
| Myogenic IGFBP5 levels in rhabdomyosarcoma are nourished by mesenchymal stromal cells and regulate growth arrest and apoptosis. Zhang Y, Katkhada K, Meng LZ, Zhao B, Tong S, Chaabane W, Kallai A, Tobin NP, Ostman A, Mega A, Ehnman M. Cell Commun Signal. 2025 Apr 15;23(1):184. doi: 10.1186/s12964-025-02171-6. PubMed |
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| p53 Deficiency in Colon Cancer Cells Promotes Tumor Progression Through the Modulation of Meflin in Fibroblasts. Kimura E, Hayashi Y, Nakagawa K, Saiki H, Kato M, Uema R, Inoue T, Yoshihara T, Sakatani A, Fukuda H, Tajiri A, Adachi Y, Murai K, Yoshii S, Tsujii Y, Shinzaki S, Iijima H, Takehara T. Cancer Sci. 2025 Jul;116(7):1871-1882. doi: 10.1111/cas.70026. Epub 2025 Apr 16. PubMed |
| Targeting the cuproptosis‑associated gene COL22A1 in glioblastoma using EMD‑1204831 and kaempferol. Chen Y, Zhang Y, Yang H, Liu Q, Sui R, Shi J, Liang H, Liu J, Xu H, Piao H. Int J Oncol. 2025 May;66(5):38. doi: 10.3892/ijo.2025.5744. Epub 2025 Apr 17. PubMed |
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| FUBP3 enhances HIV-1 transcriptional activity and regulates immune response pathways in T cells. Gibaut QMR, Li C, Cheng A, Moranguinho I, Mori LP, Valente ST. Mol Ther Nucleic Acids. 2025 Mar 25;36(2):102525. doi: 10.1016/j.omtn.2025.102525. eCollection 2025 Jun 10. PubMed |
| MFRP is a molecular hub that organizes the apical membrane of RPE cells by engaging in interactions with specific proteins and lipids. Tworak A, Smidak R, Rodrigues Menezes C, Du SW, Suh S, Choi EH, Imanishi SS, Dong Z, Lewandowski D, Fong KE, Grigorean G, Pinto AFM, Xu Q, Skowronska-Krawczyk D, Blackshaw S, Imanishi Y, Palczewski K. Proc Natl Acad Sci U S A. 2025 Apr 22;122(16):e2425523122. doi: 10.1073/pnas.2425523122. Epub 2025 Apr 18. PubMed |
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| TIMP1 secretion induced by Toxoplasma effector GRA24 via p38 MAPK signaling promotes non-disruptive parasite translocation across polarized brain endothelial monolayers. Afanaseva E, Barragan A. mSphere. 2025 May 27;10(5):e0010225. doi: 10.1128/msphere.00102-25. Epub 2025 Apr 23. PubMed |
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| Abnormal phosphorylation of human LRH1 at Ser510 predicts poor prognosis and promotes cell viability in lung squamous cell carcinoma. Mine H, Sugimoto K, Kobayashi M, Takagi H, Okabe N, Muto S, Kobayashi Y, Hashimoto Y, Suzuki H, Chiba H. BMC Cancer. 2025 Apr 23;25(1):764. doi: 10.1186/s12885-025-14160-6. PubMed |
| SNORA74A Drives Self-Renewal of Liver Cancer Stem Cells and Hepatocarcinogenesis Through Activation of Notch3 Signaling. Zhou Z, Gu Y, Yi Z, Wang J, Xiong Z, Guo H, Du Y, Zhu X, He L, Ren W, Tian Y, Wang Y, Fan Z. Adv Sci (Weinh). 2025 Jul;12(26):e2504054. doi: 10.1002/advs.202504054. Epub 2025 Apr 24. PubMed |
| Overcoming antigen loss in CAR T therapy with Vgamma9Vdelta2 CAR T-cells. Velasco Santiago M, Aehnlich P, Hulen TM, Jensen KM, Holmen Olofsson G, Met O, Thor Straten P. Immunooncol Technol. 2025 Mar 21;26:101053. doi: 10.1016/j.iotech.2025.101053. eCollection 2025 Jun. PubMed |
| Tumor-derived erythropoietin acts as an immunosuppressive switch in cancer immunity. Chiu DK, Zhang X, Cheng BY, Liu Q, Hayashi K, Yu B, Lee R, Zhang C, An X, Rajadas J, Reticker-Flynn NE, Rankin EB, Engleman EG. Science. 2025 Apr 25;388(6745):eadr3026. doi: 10.1126/science.adr3026. Epub 2025 Apr 25. PubMed |
| N-terminomics and proteomics analysis of Calpain-2 reveal key proteolytic processing of metabolic and cell adhesion proteins. Kapilan A, Bulluss M, Ziegler AR, Dabaja M, Derakhshani A, Anowai A, Armstrong V, Campden R, Young D, Sun YJ, Scott NE, Edgington-Mitchell LE, Mahajan VB, Dufour A. Protein Sci. 2025 May;34(5):e70144. doi: 10.1002/pro.70144. PubMed |
| Cancer Cell-Intrinsic Type I Interferon Signaling Promotes Antitumor Immunity in Head and Neck Squamous Cell Carcinoma. Xie G, Yang C, Pang X, Wu TC, Gu X. Cancers (Basel). 2025 Apr 10;17(8):1279. doi: 10.3390/cancers17081279. PubMed |
| Design and Characterization of Inhibitors of Cell-Mediated Degradation of APOBEC3G That Decrease HIV-1 Infectivity. Sawyer AM, Vaca CC, Malik N, Clerc I, Craft J, Hudson H, Scholtes GK, Schiltz GE, Roh M, Song C, D'Aquila RT. Viruses. 2025 Apr 1;17(4):514. doi: 10.3390/v17040514. PubMed |
| RNA polymerase II partitioning is a shared feature of diverse oncofusion condensates. Lyons H, Pradhan P, Prakasam G, Vashishtha S, Li X, Eppert M, Fornero C, Tcheuyap VT, McGlynn K, Yu Z, Raju DR, Koduru PR, Xing C, Kapur P, Brugarolas J, Sabari BR. Cell. 2025 Jul 10;188(14):3843-3862.e28. doi: 10.1016/j.cell.2025.04.002. Epub 2025 Apr 25. PubMed |
| Blocking Nitrosylation Induces Immunogenic Cell Death by Sensitizing NRAS-Mutant Melanoma to MEK Inhibitors. Srivastava J, Yadav VK, Jimenez RV, Phadatare PR, Inamdar NA, Young MM, Bacchiocchi A, Halaban R, Fang B, Pulido AM, Tsai KY, Smalley KSM, Koomen JM, Rodriguez PC, Premi S. Cancer Res. 2025 Jun 16;85(12):2268-2287. doi: 10.1158/0008-5472.CAN-24-0693. PubMed |
| Nuclear mitochondrial acetyl-CoA acetyltransferase 1 orchestrates natural killer cell-dependent antitumor immunity in colorectal cancer. Wei C, Liao K, Chen HJ, Xiao ZX, Meng Q, Liu ZK, Lu YX, Sheng H, Mo HY, Wu QN, Han Y, Zeng ZL, Guan XY, Luo HY, Ju HQ, Xu RH. Signal Transduct Target Ther. 2025 Apr 28;10(1):138. doi: 10.1038/s41392-025-02221-y. PubMed |
| Nonproteolytic ubiquitination regulates chromatin occupancy by the NCoR/SMRT/HDAC3 corepressor complex in MCF-7 breast cancer cells. Ferrero G, Cardamone MD, Luca F, Bourk E, Ricci L, Liu W, Gao Y, Burrone G, Muhammad A, Chan S, Smith E, Fan TC, Cutrupi S, Garcia-Bassets I, De Bortoli M, Rosenfeld MG, Perissi V. Proc Natl Acad Sci U S A. 2025 May 6;122(18):e2502805122. doi: 10.1073/pnas.2502805122. Epub 2025 Apr 30. PubMed |
| Functional characterization of the ATOH1 molecular subtype indicates a pro-metastatic role in small cell lung cancer. Catozzi A, Peiris Pages M, Humphrey S, Revill M, Morgan D, Roebuck J, Chen Y, Davies-Williams B, Brennan K, Mukarram Hossain ASM, Makeev VJ, Satia K, Sfyri PP, Galvin M, Coles D, Lallo A, Pearce SP, Kerr A, Priest L, Foy V, Carter M, Caeser R, Chan JM, Rudin CM, Blackhall F, Frese KK, Dive C, Simpson KL. Cell Rep. 2025 May 27;44(5):115603. doi: 10.1016/j.celrep.2025.115603. Epub 2025 Apr 29. PubMed |
| PTPN21 inhibits cell apoptosis of acute lymphoblastic leukemia induced by chemotherapeutic agents via GADD45A and JNK signaling pathway. Zhao C, Zhang Y, Huang L, Xiang J, Ye B, Zhu N. PLoS One. 2025 Apr 30;20(4):e0322273. doi: 10.1371/journal.pone.0322273. eCollection 2025. PubMed |
| LKB1 regulates JNK-dependent stress signaling and apoptotic dependency of KRAS-mutant lung cancers. Li C, Syed MU, Nimbalkar A, Shen Y, Vieira MD, Fraser C, Inde Z, Qin X, Ouyang J, Kreuzer J, Clark SE, Kelley G, Hensley EM, Morris R, Lazaro R, Belmonte B, Oh A, Walcott M, Nabel CS, Caenepeel S, Saiki AY, Rex K, Lipford JR, Heist RS, Lin JJ, Haas W, Sarosiek K, Hughes PE, Hata AN. Nat Commun. 2025 May 2;16(1):4112. doi: 10.1038/s41467-025-58753-y. PubMed |
| mTORC1 cooperates with tRNA wobble modification to sustain the protein synthesis machinery. Hermann J, Bortecen T, Kalis R, Kowar A, Pechincha C, Vogt V, Schneider M, Helm D, Krijgsveld J, Loayza-Puch F, Zuber J, Palm W. Nat Commun. 2025 May 6;16(1):4201. doi: 10.1038/s41467-025-59185-4. PubMed |
| NSP6 of SARS-CoV-2 Dually Regulates Autophagic-Lysosomal Degradation. Zhang H, Chang J, Sheng R. Int J Mol Sci. 2025 Apr 14;26(8):3699. doi: 10.3390/ijms26083699. PubMed |
| Proximity Labeling and SILAC-Based Proteomic Approach Identifies Proteins at the Interface of Homotypic and Heterotypic Cancer Cell Interactions. Saner N, Uzun C, Kirim BA, Ozkan SN, Geiszler DJ, Ozturk E, Tuncbag N, Ozlu N. Mol Cell Proteomics. 2025 Jun;24(6):100986. doi: 10.1016/j.mcpro.2025.100986. Epub 2025 May 5. PubMed |
| TRIM22 functions as a scaffold protein for autophagy initiation. Park H, Heo H, Song Y, Lee MS, Cho Y, Lee JS, Chang J, Lee S. Anim Cells Syst (Seoul). 2025 May 6;29(1):296-311. doi: 10.1080/19768354.2025.2498926. eCollection 2025. PubMed |
| Phagosomal RNA sensing through TLR8 controls susceptibility to tuberculosis. Maserumule C, Passemar C, Oh OSH, Hegyi K, Brown K, Weimann A, Dinan A, Davila S, Klapholz C, Bryant J, Verma D, Gadwa J, Krishnananthasivam S, Vongtongsalee K, Kendall E, Trelles A, Hibberd ML, Sanz J, Bertol J, Vazquez-Iniesta L, Andi K, Kumar SS, Ordway D, Prados-Rosales R, MacAry PA, Floto RA. Cell Rep. 2025 May 27;44(5):115657. doi: 10.1016/j.celrep.2025.115657. Epub 2025 May 6. PubMed |
| Predicting adenine base editing efficiencies in different cellular contexts by deep learning. Kissling L, Mollaysa A, Janjuha S, Mathis N, Marquart KF, Weber Y, Moon WJ, Lin PJC, Fan SHY, Muramatsu H, Vadovics M, Allam A, Pardi N, Tam YK, Krauthammer M, Schwank G. Genome Biol. 2025 May 8;26(1):115. doi: 10.1186/s13059-025-03586-7. PubMed |
| Hypoxia and HIF-1 inhibition enhance lentiviral transduction efficiency: a novel strategy for gene delivery optimization. Huo Q, Wang W, Dai J, Yuan X, Yu D, Xu B, Chi Y, Li H, Pei XL, Zhu G, Zhang L. BMC Biotechnol. 2025 May 10;25(1):34. doi: 10.1186/s12896-025-00969-3. PubMed |
| The mitophagy receptors BNIP3 and NIX mediate tight attachment and expansion of the isolation membrane to mitochondria. Yamashita SI, Arai R, Hada H, Padman BS, Lazarou M, Chan DC, Kanki T, Waguri S. J Cell Biol. 2025 Jul 7;224(7):e202408166. doi: 10.1083/jcb.202408166. Epub 2025 May 13. PubMed |
| Incomplete paralog compensation generates selective dependency on TRA2A in cancer. Lee AR, Tangiyan A, Singh I, Choi PS. PLoS Genet. 2025 May 14;21(5):e1011685. doi: 10.1371/journal.pgen.1011685. eCollection 2025 May. PubMed |
| Epstein-Barr virus latent membrane protein 1 subverts IMPDH pathways to drive B-cell oncometabolism. Burton EM, Maestri D, White S, Liang JH, Mitra B, Asara JM, Gewurz BE. PLoS Pathog. 2025 May 14;21(5):e1013092. doi: 10.1371/journal.ppat.1013092. eCollection 2025 May. PubMed |
| IGFBP3 enhances adipose-derived stem cell function in soft tissue injury repair via ITGB1 and ERK pathway activation. Tian S, Yu H, Yang R, Wang H, Zhao B, Wang D. Cell Biol Toxicol. 2025 May 15;41(1):85. doi: 10.1007/s10565-025-10024-8. PubMed |
| Integrative characterization of MYC RNA-binding function. Li S, Wang Z, Wang X, Wang Y, Pattarayan D, Zhang Y, Nguyen P, Bhuniya A, Chen Y, Huang H, Huang Y, Wang L, Wang J, Li S, Zhang M, Liu Y, Lee N, Yang D. Cell Genom. 2025 Jul 9;5(7):100878. doi: 10.1016/j.xgen.2025.100878. Epub 2025 May 15. PubMed |
| Targeting MYOF suppresses pancreatic ductal adenocarcinoma progression by inhibiting ILF3-LCN2 signaling through disrupting OTUB1-mediated deubiquitination of ILF3. Li Z, Zhang J, Yin J, Ma W, Liao H, Ling L, Zou Q, Cao Y, Song Y, Zheng G, Hu X, Yang G, Li N. Redox Biol. 2025 Jul;84:103665. doi: 10.1016/j.redox.2025.103665. Epub 2025 May 11. PubMed |
| TIAM1 drives prostatic branching phenotype and is a potential therapeutic target for benign prostatic hyperplasia. Khedmatgozar H, Dutta S, Dominguez M, Raju M, Patel GK, Latour D, Johnson MK, Fokar M, Warraich I, Haynes A Jr, Maurer BJ, de Riese W, Brandi L, Matusik RJ, Nandana S, Tripathi M. JCI Insight. 2025 May 20;10(12):e188062. doi: 10.1172/jci.insight.188062. eCollection 2025 Jun 23. PubMed |
| Cullin 3-mediated ubiquitination restricts enterovirus D68 replication and is counteracted by viral protease 3C. Li Y, Qu L, Tang Y, Ni F, Shen S, Guo H, Yu X-F, Wei W. J Virol. 2025 Jun 17;99(6):e0035425. doi: 10.1128/jvi.00354-25. Epub 2025 May 21. PubMed |
| Application of CRISPR-Based Epigenome Editing Tools for Engineering Programmable Embryo Models. Lodewijk GA, Kozuki S, Guiltinan C, Topacio BR, Shariati SA. Methods Mol Biol. 2025 May 22. doi: 10.1007/7651_2025_637. PubMed |
| Bat organoids reveal antiviral responses at epithelial surfaces. Kellner MJ, Monteil VM, Zelger P, Pei G, Jiao J, Onji M, Nayak K, Zilbauer M, Balkema-Buschmann A, Dorhoi A, Mirazimi A, Penninger JM. Nat Immunol. 2025 Jun;26(6):934-946. doi: 10.1038/s41590-025-02155-1. Epub 2025 May 21. PubMed |
| Immune cell infiltration into brain tumor microenvironment is mediated by Rab27-regulated vascular wall integrity. Adnani L, Meehan B, Kim M, Choi D, Rudd CE, Riazalhosseini Y, Rak J. Sci Adv. 2025 May 23;11(21):eadr6940. doi: 10.1126/sciadv.adr6940. Epub 2025 May 23. PubMed |
| Snora54 negatively regulates self-renewal of intestinal stem cells and gut regeneration via suppression of Notch2 signaling. Zhang J, Guo H, Xu Y, Xiong Z, Du Y, Zhu P, Fan Z. Sci Adv. 2025 May 23;11(21):eadv4725. doi: 10.1126/sciadv.adv4725. Epub 2025 May 23. PubMed |
| Engineered vasculature induces functional maturation of pluripotent stem cell-derived islet organoids. Jun Y, Nguyen-Ngoc KV, Sai S, Bender RHF, Gong W, Kravets V, Zhu H, Hatch CJ, Schlichting M, Gaetani R, Mallick M, Hachey SJ, Christman KL, George SC, Hughes CCW, Sander M. Dev Cell. 2025 May 20:S1534-5807(25)00262-X. doi: 10.1016/j.devcel.2025.04.024. PubMed |
| Heat shock induces alternative polyadenylation through dynamic DNA methylation and chromatin looping. Fink EE, Zhang Y, Santo B, Siddavatam A, Ou R, Nanavaty V, Lee BH, Ting AH. Cell Stress Chaperones. 2025 Jul;30(4):100084. doi: 10.1016/j.cstres.2025.100084. Epub 2025 May 22. PubMed |
| Two waves of adipogenesis in developing avian skin and dermal plasticity. Ou KL, Huang CH, Tsai S, Inaba M, Jiang TX, Chuong CM. Dev Biol. 2025 Sep;525:58-70. doi: 10.1016/j.ydbio.2025.05.019. Epub 2025 May 22. PubMed |
| Genetically encoded fluorescent reporter for polyamines. Sharma P, Kim CY, Keys HR, Imada S, Joseph AB, Ferro L, Kunchok T, Anderson R, Sun Y, Yilmaz OH, Weng JK, Jain A. Nat Commun. 2025 May 27;16(1):4921. doi: 10.1038/s41467-025-60147-z. PubMed |
| Mitochondrial calcium signaling regulates branched-chain amino acid catabolism in fibrolamellar carcinoma. Marsh NM, MacEwen MJS, Chea J, Kenerson HL, Kwong AA, Locke TM, Miralles FJ, Sapre T, Gozali N, Hart ML, Bammler TK, MacDonald JW, Sullivan LB, Atilla-Gokcumen GE, Ong SE, Scott JD, Yeung RS, Sancak Y. Sci Adv. 2025 May 30;11(22):eadu9512. doi: 10.1126/sciadv.adu9512. Epub 2025 May 28. PubMed |
Decoding post-transcriptional regulatory networks by RNA-linked CRISPR screening in human cells.
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| Evaluating the feasibility of gene replacement strategies to treat MTRFR deficiency. Pratt SL, Zarate-Mendez M, Koludarova L, Jansson S, Airavaara M, Hlushchuk I, Coleman D, Heffner C, Horvath R, Battersby BJ, Burgess RW. Dis Model Mech. 2025 May 1;18(5):dmm052120. doi: 10.1242/dmm.052120. Epub 2025 Jun 2. PubMed |
| CTG-Initiated Cryptic Peptide Translation Up- and Downstream of a Canonical ATG Start Codon Is Enhanced by TLR Stimulation and Induces Tumor Regression in Mice. Song Z, Lim Y, van Krimpen A, Geleijnse MAA, Messchendorp M, Voerman JSA, Li L, Tondeur EGM, Mishra G, Hos BJ, Grashof DGB, Stadhouders R, van de Werken HJG, Katsikis PD, Schliehe C. Cancer Immunol Res. 2025 Aug 1;13(8):1246-1265. doi: 10.1158/2326-6066.CIR-24-0467. PubMed |
| Phosphatase activity is dispensable for PRL-3-mediated oncogenesis and tumor progression. Jolly JT, Al-Hamaly MA, Smith CN, Spielmann HP, Blackburn JS. bioRxiv [Preprint]. 2025 May 18:2025.05.14.654016. doi: 10.1101/2025.05.14.654016. PubMed |
| RABEP1 amplifies front signaling in neutrophil migration. Kim DH, Syahirah R, Zheng C, Ding C, Hsu AY, Liu S, Wan J, Deng Q. bioRxiv [Preprint]. 2025 May 12:2025.05.08.652481. doi: 10.1101/2025.05.08.652481. PubMed |
| Genome-Wide CRISPR Screening Reveals That mTOR Inhibition Initiates Ferritinophagy and Ferroptosis in Head and Neck Cancer. Koshizuka K, Wu X, Sato K, Vo PTT, Murawska GM, Ishikawa T, Wang Z, Molinolo AA, Dennis EA, Nathan CO, Mali P, Gutkind JS. Cancer Res. 2025 Aug 15;85(16):3032-3051. doi: 10.1158/0008-5472.CAN-24-3785. PubMed |
| Cholesterol metabolism regulated by CAMKK2-CREB signaling promotes castration-resistant prostate cancer. Lin C, Pulliam TL, Han JJ, Xu J, Recio CV, Wilkenfeld SR, Shi Y, Kushwaha M, Bench S, Ruiz E, Senthilkumar S, Dileep J, Shepherd PDA, Navone NM, Klekers AR, Whitley EM, Ittmann MM, Eberlin LS, Wang W, Frigo DE. Cell Rep. 2025 Jun 24;44(6):115792. doi: 10.1016/j.celrep.2025.115792. Epub 2025 Jun 7. PubMed |
| RalGAP complexes control secretion and primary cilia in pancreatic disease. Apken LH, Barz H, Beel S, Michalke E, Rasche R, Verma A, Ricker A, Nusse H, Klingauf J, Kerl K, Wardelmann E, Kummel D, Steinestel K, Petho Z, Meisterernst M, Oeckinghaus A. Life Sci Alliance. 2025 Jun 9;8(8):e202403123. doi: 10.26508/lsa.202403123. Print 2025 Aug. PubMed |
| NF1 Loss Promotes EGFR Activation and Confers Sensitivity to EGFR Inhibition in NF1-Mutant Melanoma. Ibrahim M, Illa-Bochaca I, Jour G, Vega-Saenz de Miera E, Fracasso J, Ruggles K, Osman I, Schober M. Cancer Res. 2025 Sep 2;85(17):3348-3364. doi: 10.1158/0008-5472.CAN-24-3904. PubMed |
| Loss of LAPTM4A inhibits M2 polarization of tumor-associated macrophages in glioblastoma, promoting immune activation and enhancing anti-PD1 therapy. Geng J, Liang B, Zhang Z, Shan F, Zhao X, Yuan Y. Commun Biol. 2025 Jun 11;8(1):909. doi: 10.1038/s42003-025-08147-z. PubMed |
| ONECUT2 reprograms neuroendocrine fate and is an actionable therapeutic target in small cell lung cancer. Gutierrez M, Zamora I, Iriarte R, Pajares MJ, Yang Q, Qian C, Otegui N, Fernandez-Irigoyen J, Santamaria E, Alcala N, Sexton-Oates A, Fernandez-Cuesta L, Barajas M, Calvo A, Montuenga LM, Knudsen B, You S, Freeman MR, Encio I, Rotinen M. Mol Med. 2025 Jun 11;31(1):232. doi: 10.1186/s10020-025-01267-6. PubMed |
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