lentiCRISPR v2 Citations (2945)
Originally described in: Improved vectors and genome-wide libraries for CRISPR screening.Sanjana NE, Shalem O, Zhang F Nat Methods. 2014 Aug;11(8):783-4. doi: 10.1038/nmeth.3047. PubMed Journal
Articles Citing lentiCRISPR v2
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| Defining Akt actions in muscle differentiation. Gardner S, Anguiano M, Rotwein P. Am J Physiol Cell Physiol. 2012 Dec 15;303(12):C1292-300. doi: 10.1152/ajpcell.00259.2012. Epub 2012 Oct 17. PubMed |
| mTORC1 upregulation via ERK-dependent gene expression change confers intrinsic resistance to MEK inhibitors in oncogenic KRas-mutant cancer cells. Komatsu N, Fujita Y, Matsuda M, Aoki K. Oncogene. 2015 Feb 23. doi: 10.1038/onc.2015.16. PubMed |
| A Proteomic Strategy Identifies Lysine Methylation of Splicing Factor snRNP70 by the SETMAR Enzyme. Carlson SM, Moore KE, Sankaran SM, Reynoird N, Elias JE, Gozani O. J Biol Chem. 2015 May 8;290(19):12040-7. doi: 10.1074/jbc.M115.641530. Epub 2015 Mar 20. PubMed |
| LMAN1 (ERGIC-53) is a potential carrier protein for matrix metalloproteinase-9 glycoprotein secretion. Duellman T, Burnett J, Shin A, Yang J. Biochem Biophys Res Commun. 2015 Jul 3. pii: S0006-291X(15)30222-9. doi: 10.1016/j.bbrc.2015.06.164. PubMed |
| Genome-wide DNA hypomethylation and RNA:DNA hybrid accumulation in Aicardi-Goutieres syndrome. Lim YW, Sanz LA, Xu X, Hartono SR, Chedin F. Elife. 2015 Jul 16;4. doi: 10.7554/eLife.08007. PubMed |
| CDKN2B Loss Promotes Progression from Benign Melanocytic Nevus to Melanoma. McNeal AS, Liu K, Nakhate V, Natale CA, Duperret EK, Capell BC, Dentchev T, Berger SL, Herlyn M, Seykora JT, Ridky TW. Cancer Discov. 2015 Oct;5(10):1072-85. doi: 10.1158/2159-8290.CD-15-0196. Epub 2015 Jul 16. PubMed |
| An IkappaB Kinase-Regulated Feedforward Circuit Prolongs Inflammation. Perez JM, Chirieleison SM, Abbott DW. Cell Rep. 2015 Jul 28;12(4):537-44. doi: 10.1016/j.celrep.2015.06.050. Epub 2015 Jul 16. PubMed |
| Highly Efficient Genome Editing via CRISPR/Cas9 to Create Clock Gene Knockout Cells. Korge S, Grudziecki A, Kramer A. J Biol Rhythms. 2015 Oct;30(5):389-95. doi: 10.1177/0748730415597519. Epub 2015 Aug 4. PubMed |
| Alternative Wnt Signaling Activates YAP/TAZ. Park HW, Kim YC, Yu B, Moroishi T, Mo JS, Plouffe SW, Meng Z, Lin KC, Yu FX, Alexander CM, Wang CY, Guan KL. Cell. 2015 Aug 13;162(4):780-94. doi: 10.1016/j.cell.2015.07.013. PubMed |
| Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin. Zhou X, Sun L, Bastos de Oliveira F, Qi X, Brown WJ, Smolka MB, Sun Y, Hu F. J Cell Biol. 2015 Sep 14;210(6):991-1002. doi: 10.1083/jcb.201502029. PubMed |
| Establishment of leukemia inhibitory factor (LIF)-independent iPS cells with potentiated Oct4. Hirai H, Firpo M, Kikyo N. Stem Cell Res. 2015 Nov;15(3):469-80. doi: 10.1016/j.scr.2015.09.002. Epub 2015 Sep 12. PubMed |
| ZIC2-dependent OCT4 activation drives self-renewal of human liver cancer stem cells. Zhu P, Wang Y, He L, Huang G, Du Y, Zhang G, Yan X, Xia P, Ye B, Wang S, Hao L, Wu J, Fan Z. J Clin Invest. 2015 Oct 1;125(10):3795-808. doi: 10.1172/JCI81979. Epub 2015 Aug 31. PubMed |
| Differentiation-Dependent KLF4 Expression Promotes Lytic Epstein-Barr Virus Infection in Epithelial Cells. Nawandar DM, Wang A, Makielski K, Lee D, Ma S, Barlow E, Reusch J, Jiang R, Wille CK, Greenspan D, Greenspan JS, Mertz JE, Hutt-Fletcher L, Johannsen EC, Lambert PF, Kenney SC. PLoS Pathog. 2015 Oct 2;11(10):e1005195. doi: 10.1371/journal.ppat.1005195. eCollection 2015 Oct. PubMed |
| Growth factor signaling to mTORC1 by amino acid-laden macropinosomes. Yoshida S, Pacitto R, Yao Y, Inoki K, Swanson JA. J Cell Biol. 2015 Oct 12;211(1):159-72. doi: 10.1083/jcb.201504097. Epub 2015 Oct 5. PubMed |
| Tumor suppressor ASXL1 is essential for the activation of INK4B expression in response to oncogene activity and anti-proliferative signals. Wu X, Bekker-Jensen IH, Christensen J, Rasmussen KD, Sidoli S, Qi Y, Kong Y, Wang X, Cui Y, Xiao Z, Xu G, Williams K, Rappsilber J, Sonderby CK, Winther O, Jensen ON, Helin K. Cell Res. 2015 Nov;25(11):1205-18. doi: 10.1038/cr.2015.121. Epub 2015 Oct 16. PubMed |
| Genome editing of CXCR4 by CRISPR/cas9 confers cells resistant to HIV-1 infection. Hou P, Chen S, Wang S, Yu X, Chen Y, Jiang M, Zhuang K, Ho W, Hou W, Huang J, Guo D. Sci Rep. 2015 Oct 20;5:15577. doi: 10.1038/srep15577. PubMed |
| Modulation of Mitochondrial Antiviral Signaling by Human Herpesvirus 8 Interferon Regulatory Factor 1. Hwang KY, Choi YB. J Virol. 2015 Oct 28;90(1):506-20. doi: 10.1128/JVI.01903-15. PubMed |
| GRHL2 coordinates regeneration of a polarized mucociliary epithelium from basal stem cells. Gao X, Bali AS, Randell SH, Hogan BL. J Cell Biol. 2015 Nov 9;211(3):669-82. doi: 10.1083/jcb.201506014. Epub 2015 Nov 2. PubMed |
| GCN2 sustains mTORC1 suppression upon amino acid deprivation by inducing Sestrin2. Ye J, Palm W, Peng M, King B, Lindsten T, Li MO, Koumenis C, Thompson CB. Genes Dev. 2015 Nov 15;29(22):2331-6. doi: 10.1101/gad.269324.115. Epub 2015 Nov 5. PubMed |
| Cargo-selective apical exocytosis in epithelial cells is conducted by Myo5B, Slp4a, Vamp7, and Syntaxin 3. Vogel GF, Klee KM, Janecke AR, Muller T, Hess MW, Huber LA. J Cell Biol. 2015 Nov 9;211(3):587-604. doi: 10.1083/jcb.201506112. PubMed |
| Activation of Type I and III Interferon Response by Mitochondrial and Peroxisomal MAVS and Inhibition by Hepatitis C Virus. Bender S, Reuter A, Eberle F, Einhorn E, Binder M, Bartenschlager R. PLoS Pathog. 2015 Nov 20;11(11):e1005264. doi: 10.1371/journal.ppat.1005264. eCollection 2015 Nov. PubMed |
| CRISPR-Cas9 delivery to hard-to-transfect cells via membrane deformation. Han X, Liu Z, Jo MC, Zhang K, Li Y, Zeng Z, Li N, Zu Y, Qin L. Sci Adv. 2015 Aug 14;1(7):e1500454. doi: 10.1126/sciadv.1500454. eCollection 2015 Aug. PubMed |
| Peptidic degron in EID1 is recognized by an SCF E3 ligase complex containing the orphan F-box protein FBXO21. Zhang C, Li X, Adelmant G, Dobbins J, Geisen C, Oser MG, Wucherpfenning KW, Marto JA, Kaelin WG Jr. Proc Natl Acad Sci U S A. 2015 Dec 15;112(50):15372-7. doi: 10.1073/pnas.1522006112. Epub 2015 Dec 2. PubMed |
| Characterization of a Novel Human-Specific STING Agonist that Elicits Antiviral Activity Against Emerging Alphaviruses. Sali TM, Pryke KM, Abraham J, Liu A, Archer I, Broeckel R, Staverosky JA, Smith JL, Al-Shammari A, Amsler L, Sheridan K, Nilsen A, Streblow DN, DeFilippis VR. PLoS Pathog. 2015 Dec 8;11(12):e1005324. doi: 10.1371/journal.ppat.1005324. eCollection 2015 Dec. PubMed |
| LUBAC-Recruited CYLD and A20 Regulate Gene Activation and Cell Death by Exerting Opposing Effects on Linear Ubiquitin in Signaling Complexes. Draber P, Kupka S, Reichert M, Draberova H, Lafont E, de Miguel D, Spilgies L, Surinova S, Taraborrelli L, Hartwig T, Rieser E, Martino L, Rittinger K, Walczak H. Cell Rep. 2015 Dec 15;13(10):2258-72. doi: 10.1016/j.celrep.2015.11.009. Epub 2015 Dec 6. PubMed |
| Spell Checking Nature: Versatility of CRISPR/Cas9 for Developing Treatments for Inherited Disorders. Wojtal D, Kemaladewi DU, Malam Z, Abdullah S, Wong TW, Hyatt E, Baghestani Z, Pereira S, Stavropoulos J, Mouly V, Mamchaoui K, Muntoni F, Voit T, Gonorazky HD, Dowling JJ, Wilson MD, Mendoza-Londono R, Ivakine EA, Cohn RD. Am J Hum Genet. 2016 Jan 7;98(1):90-101. doi: 10.1016/j.ajhg.2015.11.012. Epub 2015 Dec 10. PubMed |
| Functional genetic screens for enhancer elements in the human genome using CRISPR-Cas9. Korkmaz G, Lopes R, Ugalde AP, Nevedomskaya E, Han R, Myacheva K, Zwart W, Elkon R, Agami R. Nat Biotechnol. 2016 Feb;34(2):192-8. doi: 10.1038/nbt.3450. Epub 2016 Jan 11. PubMed |
| Epithelial-to-Mesenchymal Transition of RPE Cells In Vitro Confers Increased beta1,6-N-Glycosylation and Increased Susceptibility to Galectin-3 Binding. Priglinger CS, Obermann J, Szober CM, Merl-Pham J, Ohmayer U, Behler J, Gruhn F, Kreutzer TC, Wertheimer C, Geerlof A, Priglinger SG, Hauck SM. PLoS One. 2016 Jan 13;11(1):e0146887. doi: 10.1371/journal.pone.0146887. eCollection 2016. PubMed |
TRIM5alpha degradation via autophagy is not required for retroviral restriction.
Imam S, Talley S, Nelson RS, Dharan A, O'Connor C, Hope TJ, Campbell EM.
J Virol. 2016 Jan 13. pii: JVI.03033-15.
PubMed
Associated Plasmids |
| Exploiting the CRISPR/Cas9 PAM Constraint for Single-Nucleotide Resolution Interventions. Li Y, Mendiratta S, Ehrhardt K, Kashyap N, White MA, Bleris L. PLoS One. 2016 Jan 20;11(1):e0144970. doi: 10.1371/journal.pone.0144970. eCollection 2016. PubMed |
| Impaired killing of Candida albicans by granulocytes mobilized for transfusion purposes: a role for granule components. Gazendam RP, van de Geer A, van Hamme JL, Tool AT, van Rees DJ, Aarts CE, van den Biggelaar M, van Alphen F, Verkuijlen P, Meijer AB, Janssen H, Roos D, van den Berg TK, Kuijpers TW. Haematologica. 2016 May;101(5):587-96. doi: 10.3324/haematol.2015.136630. Epub 2016 Jan 22. PubMed |
| Is BOK required for apoptosis induced by endoplasmic reticulum stress? Fernandez-Marrero Y, Ke F, Echeverry N, Bouillet P, Bachmann D, Strasser A, Kaufmann T. Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):E492-3. doi: 10.1073/pnas.1516347113. Epub 2016 Jan 25. PubMed |
| NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux. He Y, Zeng MY, Yang D, Motro B, Nunez G. Nature. 2016 Feb 18;530(7590):354-7. doi: 10.1038/nature16959. Epub 2016 Jan 27. PubMed |
| DeltaNp63 regulates cell proliferation, differentiation, adhesion, and migration in the BL2 subtype of basal-like breast cancer. Orzol P, Nekulova M, Holcakova J, Muller P, Votesek B, Coates PJ. Tumour Biol. 2016 Jan 29. PubMed |
Mito-priming as a method to engineer Bcl-2 addiction.
Lopez J, Bessou M, Riley JS, Giampazolias E, Todt F, Rochegue T, Oberst A, Green DR, Edlich F, Ichim G, Tait SW.
Nat Commun. 2016 Feb 2;7:10538. doi: 10.1038/ncomms10538.
PubMed
Associated Plasmids |
| The Sigma-2 Receptor and Progesterone Receptor Membrane Component 1 are Different Binding Sites Derived From Independent Genes. Chu UB, Mavlyutov TA, Chu ML, Yang H, Schulman A, Mesangeau C, McCurdy CR, Guo LW, Ruoho AE. EBioMedicine. 2015 Oct 19;2(11):1806-13. doi: 10.1016/j.ebiom.2015.10.017. eCollection 2015 Nov. PubMed |
| MUC1-C drives MYC in multiple myeloma. Tagde A, Rajabi H, Bouillez A, Alam M, Gali R, Bailey S, Tai YT, Hideshima T, Anderson K, Avigan D, Kufe D. Blood. 2016 May 26;127(21):2587-97. doi: 10.1182/blood-2015-07-659151. Epub 2016 Feb 23. PubMed |
| The retrovirus HTLV-1 inserts an ectopic CTCF-binding site into the human genome. Satou Y, Miyazato P, Ishihara K, Yaguchi H, Melamed A, Miura M, Fukuda A, Nosaka K, Watanabe T, Rowan AG, Nakao M, Bangham CR. Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):3054-9. doi: 10.1073/pnas.1423199113. Epub 2016 Feb 29. PubMed |
| Screening and identification of proteins interacting with IL-24 by the yeast two-hybrid screen, Co-IP, and FRET assays. Hu H, Wang T, Chen J, Yu F, Liu H, Zuo Z, Yang Z, Fan H. Anticancer Drugs. 2016 Apr;27(4):318-27. doi: 10.1097/CAD.0000000000000343. PubMed |
| Single Guide RNA Library Design and Construction. Wang T, Lander ES, Sabatini DM. Cold Spring Harb Protoc. 2016 Mar 1;2016(3):pdb.prot090803. doi: 10.1101/pdb.prot090803. PubMed |
| Global Analysis of Cellular Protein Flux Quantifies the Selectivity of Basal Autophagy. Zhang T, Shen S, Qu J, Ghaemmaghami S. Cell Rep. 2016 Mar 15;14(10):2426-39. doi: 10.1016/j.celrep.2016.02.040. Epub 2016 Mar 3. PubMed |
| Editing of mouse and human immunoglobulin genes by CRISPR-Cas9 system. Cheong TC, Compagno M, Chiarle R. Nat Commun. 2016 Mar 9;7:10934. doi: 10.1038/ncomms10934. PubMed |
| Thrombin-Mediated Direct Activation of Proteinase-Activated Receptor-2: Another Target for Thrombin Signaling. Mihara K, Ramachandran R, Saifeddine M, Hansen KK, Renaux B, Polley D, Gibson S, Vanderboor C, Hollenberg MD. Mol Pharmacol. 2016 May;89(5):606-14. doi: 10.1124/mol.115.102723. Epub 2016 Mar 8. PubMed |
| NK Cells Respond to Haptens by the Activation of Calcium Permeable Plasma Membrane Channels. Grandclement C, Pick H, Vogel H, Held W. PLoS One. 2016 Mar 10;11(3):e0151031. doi: 10.1371/journal.pone.0151031. eCollection 2016. PubMed |
| The deubiquitinase Usp27x stabilizes the BH3-only protein Bim and enhances apoptosis. Weber A, Heinlein M, Dengjel J, Alber C, Singh PK, Hacker G. EMBO Rep. 2016 May;17(5):724-38. doi: 10.15252/embr.201541392. Epub 2016 Mar 24. PubMed |
| ROR-gamma drives androgen receptor expression and represents a therapeutic target in castration-resistant prostate cancer. Wang J, Zou JX, Xue X, Cai D, Zhang Y, Duan Z, Xiang Q, Yang JC, Louie MC, Borowsky AD, Gao AC, Evans CP, Lam KS, Xu J, Kung HJ, Evans RM, Xu Y, Chen HW. Nat Med. 2016 May;22(5):488-96. doi: 10.1038/nm.4070. Epub 2016 Mar 28. PubMed |
| ATRX binds to atypical chromatin domains at the 3' exons of zinc finger genes to preserve H3K9me3 enrichment. Valle-Garcia D, Qadeer ZA, McHugh DS, Ghiraldini FG, Chowdhury AH, Hasson D, Dyer MA, Recillas-Targa F, Bernstein E. Epigenetics. 2016 Jun 2;11(6):398-414. doi: 10.1080/15592294.2016.1169351. Epub 2016 Mar 30. PubMed |
| A homeobox protein, NKX6.1, up-regulates interleukin-6 expression for cell growth in basal-like breast cancer cells. Li W, Itou J, Tanaka S, Nishimura T, Sato F, Toi M. Exp Cell Res. 2016 May 1;343(2):177-89. doi: 10.1016/j.yexcr.2016.03.023. Epub 2016 Mar 28. PubMed |
| Activation by SLAM Family Receptors Contributes to NK Cell Mediated "Missing-Self" Recognition. Alari-Pahissa E, Grandclement C, Jeevan-Raj B, Leclercq G, Veillette A, Held W. PLoS One. 2016 Apr 7;11(4):e0153236. doi: 10.1371/journal.pone.0153236. eCollection 2016. PubMed |
| Genome-wide CRISPR screen reveals novel host factors required for Staphylococcus aureus alpha-hemolysin-mediated toxicity. Virreira Winter S, Zychlinsky A, Bardoel BW. Sci Rep. 2016 Apr 12;6:24242. doi: 10.1038/srep24242. PubMed |
| Genome-Wide CRISPR-Cas9 Screen Identifies MicroRNAs That Regulate Myeloid Leukemia Cell Growth. Wallace J, Hu R, Mosbruger TL, Dahlem TJ, Stephens WZ, Rao DS, Round JL, O'Connell RM. PLoS One. 2016 Apr 15;11(4):e0153689. doi: 10.1371/journal.pone.0153689. eCollection 2016. PubMed |
| NOD1 Participates in the Innate Immune Response Triggered by Hepatitis C Virus Polymerase. Vegna S, Gregoire D, Moreau M, Lassus P, Durantel D, Assenat E, Hibner U, Simonin Y. J Virol. 2016 Jun 10;90(13):6022-35. doi: 10.1128/JVI.03230-15. Print 2016 Jul 1. PubMed |
| DHX9/RHA Binding to the PBS-Segment of the Genomic RNA during HIV-1 Assembly Bolsters Virion Infectivity. Boeras I, Song Z, Moran A, Franklin J, Brown WC, Johnson M, Boris-Lawrie K, Heng X. J Mol Biol. 2016 Jun 5;428(11):2418-29. doi: 10.1016/j.jmb.2016.04.011. Epub 2016 Apr 21. PubMed |
| CRISPR knockout screening outperforms shRNA and CRISPRi in identifying essential genes. Evers B, Jastrzebski K, Heijmans JP, Grernrum W, Beijersbergen RL, Bernards R. Nat Biotechnol. 2016 Jun;34(6):631-3. doi: 10.1038/nbt.3536. Epub 2016 Apr 25. PubMed |
| An essential role for Grk2 in Hedgehog signalling downstream of Smoothened. Zhao Z, Lee RT, Pusapati GV, Iyu A, Rohatgi R, Ingham PW. EMBO Rep. 2016 May;17(5):739-52. doi: 10.15252/embr.201541532. Epub 2016 Apr 4. PubMed |
| Sex steroids regulate skin pigmentation through nonclassical membrane-bound receptors. Natale CA, Duperret EK, Zhang J, Sadeghi R, Dahal A, O'Brien KT, Cookson R, Winkler JD, Ridky TW. Elife. 2016 Apr 26;5. pii: e15104. doi: 10.7554/eLife.15104. PubMed |
| EVI1 Interferes with Myeloid Maturation via Transcriptional Repression of Cebpa, via Binding to Two Far Downstream Regulatory Elements. Wilson M, Tsakraklides V, Tran M, Xiao YY, Zhang Y, Perkins AS. J Biol Chem. 2016 Jun 24;291(26):13591-607. doi: 10.1074/jbc.M115.708156. Epub 2016 Apr 21. PubMed |
| The mitochondrial calcium uniporter regulates breast cancer progression via HIF-1alpha. Tosatto A, Sommaggio R, Kummerow C, Bentham RB, Blacker TS, Berecz T, Duchen MR, Rosato A, Bogeski I, Szabadkai G, Rizzuto R, Mammucari C. EMBO Mol Med. 2016 May 2;8(5):569-85. doi: 10.15252/emmm.201606255. PubMed |
| RBFOX1 and RBFOX2 are dispensable in iPSCs and iPSC-derived neurons and do not contribute to neural-specific paternal UBE3A silencing. Chen PF, Hsiao JS, Sirois CL, Chamberlain SJ. Sci Rep. 2016 May 5;6:25368. doi: 10.1038/srep25368. PubMed |
| Characterizing the differences between the 2D and 3D measurements of spine in adolescent idiopathic scoliosis. Pasha S, Cahill PJ, Dormans JP, Flynn JM. Eur Spine J. 2016 Oct;25(10):3137-3145. Epub 2016 May 4. PubMed |
| RISC-mediated control of selected chromatin regulators stabilizes ground state pluripotency of mouse embryonic stem cells. Pandolfini L, Luzi E, Bressan D, Ucciferri N, Bertacchi M, Brandi R, Rocchiccioli S, D'Onofrio M, Cremisi F. Genome Biol. 2016 May 6;17(1):94. doi: 10.1186/s13059-016-0952-x. PubMed |
| NFAT restricts osteochondroma formation from entheseal progenitors. Ge X, Tsang K, He L, Garcia RA, Ermann J, Mizoguchi F, Zhang M, Zhou B, Zhou B, Aliprantis AO. JCI Insight. 2016 Apr;1(4):e86254. PubMed |
| Targeted positron emission tomography imaging of CXCR4 expression in patients with acute myeloid leukemia. Herhaus P, Habringer S, Philipp-Abbrederis K, Vag T, Gerngross C, Schottelius M, Slotta-Huspenina J, Steiger K, Altmann T, Weisser T, Steidle S, Schick M, Jacobs L, Slawska J, Mueller-Thomas C, Verbeek M, Subklewe M, Peschel C, Wester HJ, Schwaiger M, Goetze K, Keller U. Haematologica. 2016 May 12. pii: haematol.2016.142976. PubMed |
| The histone methyltransferase EZH2 as a novel prosurvival factor in clinically aggressive chronic lymphocytic leukemia. Papakonstantinou N, Ntoufa S, Chartomatsidou E, Kotta K, Agathangelidis A, Giassafaki L, Karamanli T, Bele P, Moysiadis T, Baliakas P, Sutton LA, Stavroyianni N, Anagnostopoulos A, Makris AM, Ghia P, Rosenquist R, Stamatopoulos K. Oncotarget. 2016 Jun 14;7(24):35946-35959. doi: 10.18632/oncotarget.9371. PubMed |
| Discovery of a Small-Molecule BMP Sensitizer for Human Embryonic Stem Cell Differentiation. Feng L, Cook B, Tsai SY, Zhou T, LaFlamme B, Evans T, Chen S. Cell Rep. 2016 May 31;15(9):2063-75. doi: 10.1016/j.celrep.2016.04.066. Epub 2016 May 19. PubMed |
Whole organism lineage tracing by combinatorial and cumulative genome editing.
McKenna A, Findlay GM, Gagnon JA, Horwitz MS, Schier AF, Shendure J.
Science. 2016 May 26. pii: aaf7907.
PubMed
Associated Plasmids |
| Combining single-strand oligodeoxynucleotides and CRISPR/Cas9 to correct gene mutations in Beta-thalassemia-induced Pluripotent Stem Cells. Niu X, He W, Song B, Ou Z, Fan D, Chen Y, Fan Y, Sun X. J Biol Chem. 2016 Jun 10. pii: jbc.M116.719237. PubMed |
| Autocrine Complement Inhibits IL10-Dependent T-Cell Mediated Antitumor Immunity to Promote Tumor Progression. Wang Y, Sun SN, Liu Q, Yu YY, Guo J, Wang K, Xing BC, Zheng QF, Campa MJ, Patz EF, Li SY, He YW. Cancer Discov. 2016 Jun 13. pii: CD-15-1412. PubMed |
| Combination of the clustered regularly interspaced short palindromic repeats (CRISPR)-associated 9 technique with the piggybac transposon system for mouse in utero electroporation to study cortical development. Cheng M, Jin X, Mu L, Wang F, Li W, Zhong X, Liu X, Shen W, Liu Y, Zhou Y. J Neurosci Res. 2016 Jun 18. doi: 10.1002/jnr.23776. PubMed |
| Tyrosine phosphorylation regulates ERbeta ubiquitination, protein turnover, and inhibition of breast cancer. Yuan B, Cheng L, Gupta K, Chiang HC, Gupta HB, Sareddy GR, Wang D, Lathrop K, Elledge R, Wang P, McHardy S, Vadlamudi R, Curiel TJ, Hu Y, Ye Q, Li R. Oncotarget. 2016 Jul 5;7(27):42585-42597. doi: 10.18632/oncotarget.10018. PubMed |
| Viral FGARAT Homolog ORF75 of Rhesus Monkey Rhadinovirus Effects Proteasomal Degradation of the ND10 Components SP100 and PML. Hahn AS, Grosskopf AK, Jungnickl D, Scholz B, Ensser A. J Virol. 2016 Aug 12;90(17):8013-28. doi: 10.1128/JVI.01181-16. Print 2016 Sep 1. PubMed |
| Practical Considerations for Using Pooled Lentiviral CRISPR Libraries. McDade JR, Waxmonsky NC, Swanson LE, Fan M. Curr Protoc Mol Biol. 2016 Jul 1;115:31.5.1-31.5.13. doi: 10.1002/cpmb.8. PubMed |
| Multiple mechanisms disrupt the let-7 microRNA family in neuroblastoma. Powers JT, Tsanov KM, Pearson DS, Roels F, Spina CS, Ebright R, Seligson M, de Soysa Y, Cahan P, Theissen J, Tu HC, Han A, Kurek KC, LaPier GS, Osborne JK, Ross SJ, Cesana M, Collins JJ, Berthold F, Daley GQ. Nature. 2016 Jul 14;535(7611):246-51. doi: 10.1038/nature18632. PubMed |
| Homologous recombination-dependent repair of telomeric DSBs in proliferating human cells. Mao P, Liu J, Zhang Z, Zhang H, Liu H, Gao S, Rong YS, Zhao Y. Nat Commun. 2016 Jul 11;7:12154. doi: 10.1038/ncomms12154. PubMed |
| 53BP1 and USP28 mediate p53 activation and G1 arrest after centrosome loss or extended mitotic duration. Meitinger F, Anzola JV, Kaulich M, Richardson A, Stender JD, Benner C, Glass CK, Dowdy SF, Desai A, Shiau AK, Oegema K. J Cell Biol. 2016 Jul 18;214(2):155-66. doi: 10.1083/jcb.201604081. PubMed |
| PARP Inhibitor Activity Correlates with SLFN11 Expression and Demonstrates Synergy with Temozolomide in Small Cell Lung Cancer. Lok BH, Gardner EE, Schneeberger VE, Ni A, Desmeules P, Rekhtman N, de Stanchina E, Teicher BA, Riaz N, Powell SN, Poirier JT, Rudin CM. Clin Cancer Res. 2017 Jan 15;23(2):523-535. doi: 10.1158/1078-0432.CCR-16-1040. Epub 2016 Jul 20. PubMed |
| Activation of cell-surface proteases promotes necroptosis, inflammation and cell migration. Cai Z, Zhang A, Choksi S, Li W, Li T, Zhang XM, Liu ZG. Cell Res. 2016 Aug;26(8):886-900. doi: 10.1038/cr.2016.87. Epub 2016 Jul 22. PubMed |
| CD19 CAR immune pressure induces B-precursor acute lymphoblastic leukaemia lineage switch exposing inherent leukaemic plasticity. Jacoby E, Nguyen SM, Fountaine TJ, Welp K, Gryder B, Qin H, Yang Y, Chien CD, Seif AE, Lei H, Song YK, Khan J, Lee DW, Mackall CL, Gardner RA, Jensen MC, Shern JF, Fry TJ. Nat Commun. 2016 Jul 27;7:12320. doi: 10.1038/ncomms12320. PubMed |
| Prediction and Validation of Transcription Factors Modulating the Expression of Sestrin3 Gene Using an Integrated Computational and Experimental Approach. Srivastava R, Zhang Y, Xiong X, Zhang X, Pan X, Dong XC, Liangpunsakul S, Janga SC. PLoS One. 2016 Jul 28;11(7):e0160228. doi: 10.1371/journal.pone.0160228. eCollection 2016. PubMed |
| Musashi1 Impacts Radio-Resistance in Glioblastoma by Controlling DNA-Protein Kinase Catalytic Subunit. de Araujo PR, Gorthi A, da Silva AE, Tonapi SS, Vo DT, Burns SC, Qiao M, Uren PJ, Yuan ZM, Bishop AJ, Penalva LO. Am J Pathol. 2016 Sep;186(9):2271-8. doi: 10.1016/j.ajpath.2016.05.020. Epub 2016 Jul 25. PubMed |
| Parallel reverse genetic screening in mutant human cells using transcriptomics. Gapp BV, Konopka T, Penz T, Dalal V, Burckstummer T, Bock C, Nijman SM. Mol Syst Biol. 2016 Aug 1;12(8):879. doi: 10.15252/msb.20166890. PubMed |
| Chromatin-Remodeling Complex SWI/SNF Controls Multidrug Resistance by Transcriptionally Regulating the Drug Efflux Pump ABCB1. Dubey R, Lebensohn AM, Bahrami-Nejad Z, Marceau C, Champion M, Gevaert O, Sikic BI, Carette JE, Rohatgi R. Cancer Res. 2016 Oct 1;76(19):5810-5821. Epub 2016 Aug 8. PubMed |
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| Genetic modification of ER-Hoxb8 osteoclast precursors using CRISPR/Cas9 as a novel way to allow studies on osteoclast biology. Di Ceglie I, van den Akker GG, Ascone G, Ten Harkel B, Hacker H, van de Loo FA, Koenders MI, van der Kraan PM, de Vries TJ, Vogl T, Roth J, van Lent PL. J Leukoc Biol. 2016 Dec 5. pii: jlb.1AB0416-180RR. PubMed |
| STAT1 is essential for the inhibition of hepatitis C virus replication by interferon-lambda but not by interferon-alpha. Yamauchi S, Takeuchi K, Chihara K, Honjoh C, Kato Y, Yoshiki H, Hotta H, Sada K. Sci Rep. 2016 Dec 8;6:38336. doi: 10.1038/srep38336. PubMed |
| Viral DNA Sensors IFI16 and Cyclic GMP-AMP Synthase Possess Distinct Functions in Regulating Viral Gene Expression, Immune Defenses, and Apoptotic Responses during Herpesvirus Infection. Diner BA, Lum KK, Toettcher JE, Cristea IM. MBio. 2016 Nov 15;7(6). pii: e01553-16. doi: 10.1128/mBio.01553-16. PubMed |
Genome-Wide CRISPR Screen Identifies Regulators of Mitogen-Activated Protein Kinase as Suppressors of Liver Tumors in Mice.
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| Epigenetic and Transcriptional Regulation of IRAK-M Expression in Macrophages. Lyroni K, Patsalos A, Daskalaki MG, Doxaki C, Soennichsen B, Helms M, Liapis I, Zacharioudaki V, Kampranis SC, Tsatsanis C. J Immunol. 2016 Dec 23. pii: 1600009. doi: 10.4049/jimmunol.1600009. PubMed |
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| Cytosolic Fc receptor TRIM21 inhibits seeded tau aggregation. McEwan WA, Falcon B, Vaysburd M, Clift D, Oblak AL, Ghetti B, Goedert M, James LC. Proc Natl Acad Sci U S A. 2017 Jan 17;114(3):574-579. doi: 10.1073/pnas.1607215114. Epub 2017 Jan 3. PubMed |
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| Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies. Herold N, Rudd SG, Ljungblad L, Sanjiv K, Myrberg IH, Paulin CB, Heshmati Y, Hagenkort A, Kutzner J, Page BD, Calderon-Montano JM, Loseva O, Jemth AS, Bulli L, Axelsson H, Tesi B, Valerie NC, Hoglund A, Bladh J, Wiita E, Sundin M, Uhlin M, Rassidakis G, Heyman M, Tamm KP, Warpman-Berglund U, Walfridsson J, Lehmann S, Grander D, Lundback T, Kogner P, Henter JI, Helleday T, Schaller T. Nat Med. 2017 Jan 9. doi: 10.1038/nm.4265. PubMed |
| FGF19/FGFR4 signaling contributes to the resistance of hepatocellular carcinoma to sorafenib. Gao L, Wang X, Tang Y, Huang S, Hu CA, Teng Y. J Exp Clin Cancer Res. 2017 Jan 9;36(1):8. doi: 10.1186/s13046-016-0478-9. PubMed |
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| Inhibition of 4EBP phosphorylation mediates the cytotoxic effect of mechanistic target of rapamycin kinase inhibitors in aggressive B-cell lymphomas. Bi C, Zhang X, Lu T, Zhang X, Wang X, Meng B, Zhang H, Wang P, Vose JM, Chan WC, McKeithan TW, Fu K. Haematologica. 2017 Apr;102(4):755-764. doi: 10.3324/haematol.2016.159160. Epub 2017 Jan 19. PubMed |
| ApoE2, ApoE3, and ApoE4 Differentially Stimulate APP Transcription and Abeta Secretion. Huang YA, Zhou B, Wernig M, Sudhof TC. Cell. 2017 Jan 26;168(3):427-441.e21. doi: 10.1016/j.cell.2016.12.044. Epub 2017 Jan 19. PubMed |
An Argonaute phosphorylation cycle promotes microRNA-mediated silencing.
Golden RJ, Chen B, Li T, Braun J, Manjunath H, Chen X, Wu J, Schmid V, Chang TC, Kopp F, Ramirez-Martinez A, Tagliabracci VS, Chen ZJ, Xie Y, Mendell JT.
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| Creation of Novel Protein Variants with CRISPR/Cas9-Mediated Mutagenesis: Turning a Screening By-Product into a Discovery Tool. Donovan KF, Hegde M, Sullender M, Vaimberg EW, Johannessen CM, Root DE, Doench JG. PLoS One. 2017 Jan 24;12(1):e0170445. doi: 10.1371/journal.pone.0170445. eCollection 2017. PubMed |
| The PIDDosome activates p53 in response to supernumerary centrosomes. Fava LL, Schuler F, Sladky V, Haschka MD, Soratroi C, Eiterer L, Demetz E, Weiss G, Geley S, Nigg EA, Villunger A. Genes Dev. 2017 Jan 1;31(1):34-45. doi: 10.1101/gad.289728.116. PubMed |
| YAP-IL-6ST autoregulatory loop activated on APC loss controls colonic tumorigenesis. Taniguchi K, Moroishi T, de Jong PR, Krawczyk M, Grebbin BM, Luo H, Xu RH, Golob-Schwarzl N, Schweiger C, Wang K, Di Caro G, Feng Y, Fearon ER, Raz E, Kenner L, Farin HF, Guan KL, Haybaeck J, Datz C, Zhang K, Karin M. Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1643-1648. doi: 10.1073/pnas.1620290114. Epub 2017 Jan 27. PubMed |
| Mutations in EXTL3 Cause Neuro-immuno-skeletal Dysplasia Syndrome. Oud MM, Tuijnenburg P, Hempel M, van Vlies N, Ren Z, Ferdinandusse S, Jansen MH, Santer R, Johannsen J, Bacchelli C, Alders M, Li R, Davies R, Dupuis L, Cale CM, Wanders RJA, Pals ST, Ocaka L, James C, Muller I, Lehmberg K, Strom T, Engels H, Williams HJ, Beales P, Roepman R, Dias P, Brunner HG, Cobben JM, Hall C, Hartley T, Le Quesne Stabej P, Mendoza-Londono R, Davies EG, de Sousa SB, Lessel D, Arts HH, Kuijpers TW. Am J Hum Genet. 2017 Feb 2;100(2):281-296. doi: 10.1016/j.ajhg.2017.01.013. Epub 2017 Jan 26. PubMed |
| Inhibition of CDK8 mediator kinase suppresses estrogen dependent transcription and the growth of estrogen receptor positive breast cancer. McDermott MS, Chumanevich AA, Lim CU, Liang J, Chen M, Altilia S, Oliver D, Rae JM, Shtutman M, Kiaris H, Gyorffy B, Roninson IB, Broude EV. Oncotarget. 2017 Feb 21;8(8):12558-12575. doi: 10.18632/oncotarget.14894. PubMed |
| microRNA-210-3p depletion by CRISPR/Cas9 promoted tumorigenesis through revival of TWIST1 in renal cell carcinoma. Yoshino H, Yonemori M, Miyamoto K, Tatarano S, Kofuji S, Nohata N, Nakagawa M, Enokida H. Oncotarget. 2017 Mar 28;8(13):20881-20894. doi: 10.18632/oncotarget.14930. PubMed |
| Genome Editing Reveals Glioblastoma Addiction to MicroRNA-10b. El Fatimy R, Subramanian S, Uhlmann EJ, Krichevsky AM. Mol Ther. 2017 Feb 1;25(2):368-378. doi: 10.1016/j.ymthe.2016.11.004. PubMed |
| Erythroid specific activator GATA-1-dependent interactions between CTCF sites around the beta-globin locus. Kang Y, Kim YW, Kang J, Yun WJ, Kim A. Biochim Biophys Acta. 2017 Apr;1860(4):416-426. doi: 10.1016/j.bbagrm.2017.01.013. Epub 2017 Feb 1. PubMed |
| A genetic interaction analysis identifies cancer drivers that modify EGFR dependency. Liao S, Davoli T, Leng Y, Li MZ, Xu Q, Elledge SJ. Genes Dev. 2017 Jan 15;31(2):184-196. doi: 10.1101/gad.291948.116. Epub 2017 Feb 6. PubMed |
| AXL-dependent infection of human fetal endothelial cells distinguishes Zika virus from other pathogenic flaviviruses. Richard AS, Shim BS, Kwon YC, Zhang R, Otsuka Y, Schmitt K, Berri F, Diamond MS, Choe H. Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):2024-2029. doi: 10.1073/pnas.1620558114. Epub 2017 Feb 6. PubMed |
| Challenges of CRISPR/Cas9 applications for long non-coding RNA genes. Goyal A, Myacheva K, Gross M, Klingenberg M, Duran Arque B, Diederichs S. Nucleic Acids Res. 2017 Feb 17;45(3):e12. doi: 10.1093/nar/gkw883. PubMed |
| Cytosolic DNA Promotes Signal Transducer and Activator of Transcription 3 (STAT3) Phosphorylation by TANK-binding Kinase 1 (TBK1) to Restrain STAT3 Activity. Hsia HC, Hutti JE, Baldwin AS. J Biol Chem. 2017 Mar 31;292(13):5405-5417. doi: 10.1074/jbc.M116.771964. Epub 2017 Feb 10. PubMed |
| The nuclear transport receptor Importin-11 is a tumor suppressor that maintains PTEN protein. Chen M, Nowak DG, Narula N, Robinson B, Watrud K, Ambrico A, Herzka TM, Zeeman ME, Minderer M, Zheng W, Ebbesen SH, Plafker KS, Stahlhut C, Wang VM, Wills L, Nasar A, Castillo-Martin M, Cordon-Cardo C, Wilkinson JE, Powers S, Sordella R, Altorki NK, Mittal V, Stiles BM, Plafker SM, Trotman LC. J Cell Biol. 2017 Mar 6;216(3):641-656. doi: 10.1083/jcb.201604025. Epub 2017 Feb 13. PubMed |
| Phosphatidylinositol 3-kinase delta blockade increases genomic instability in B cells. Compagno M, Wang Q, Pighi C, Cheong TC, Meng FL, Poggio T, Yeap LS, Karaca E, Blasco RB, Langellotto F, Ambrogio C, Voena C, Wiestner A, Kasar SN, Brown JR, Sun J, Wu CJ, Gostissa M, Alt FW, Chiarle R. Nature. 2017 Feb 23;542(7642):489-493. doi: 10.1038/nature21406. Epub 2017 Feb 15. PubMed |
| SZT2 dictates GATOR control of mTORC1 signalling. Peng M, Yin N, Li MO. Nature. 2017 Mar 16;543(7645):433-437. doi: 10.1038/nature21378. Epub 2017 Feb 15. PubMed |
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| OTX2 Activity at Distal Regulatory Elements Shapes the Chromatin Landscape of Group 3 Medulloblastoma. Boulay G, Awad ME, Riggi N, Archer TC, Iyer S, Boonseng WE, Rossetti NE, Naigles B, Rengarajan S, Volorio A, Kim JC, Mesirov JP, Tamayo P, Pomeroy SL, Aryee MJ, Rivera MN. Cancer Discov. 2017 Mar;7(3):288-301. doi: 10.1158/2159-8290.CD-16-0844. Epub 2017 Feb 17. PubMed |
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| Multiple Histone Lysine Methyltransferases Are Required for the Establishment and Maintenance of HIV-1 Latency. Nguyen K, Das B, Dobrowolski C, Karn J. MBio. 2017 Feb 28;8(1). pii: mBio.00133-17. doi: 10.1128/mBio.00133-17. PubMed |
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DUX4-induced dsRNA and MYC mRNA stabilization activate apoptotic pathways in human cell models of facioscapulohumeral dystrophy.
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| The vacuolar-ATPase complex and assembly factors, TMEM199 and CCDC115, control HIF1alpha prolyl hydroxylation by regulating cellular iron levels. Miles AL, Burr SP, Grice GL, Nathan JA. Elife. 2017 Mar 15;6. doi: 10.7554/eLife.22693. PubMed |
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| Mouse Mammary Tumor Virus Signal Peptide Uses a Novel p97-Dependent and Derlin-Independent Retrotranslocation Mechanism To Escape Proteasomal Degradation. Byun H, Das P, Yu H, Aleman A, Lozano MM, Matouschek A, Dudley JP. MBio. 2017 Mar 28;8(2). pii: e00328-17. doi: 10.1128/mBio.00328-17. PubMed |
| CRISPR-Cas9 Mediated Gene-Silencing of the Mutant Huntingtin Gene in an In Vitro Model of Huntington's Disease. Kolli N, Lu M, Maiti P, Rossignol J, Dunbar GL. Int J Mol Sci. 2017 Apr 2;18(4). pii: E754. doi: 10.3390/ijms18040754. PubMed |
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| Isolated polycystic liver disease genes define effectors of polycystin-1 function. Besse W, Dong K, Choi J, Punia S, Fedeles SV, Choi M, Gallagher AR, Huang EB, Gulati A, Knight J, Mane S, Tahvanainen E, Tahvanainen P, Sanna-Cherchi S, Lifton RP, Watnick T, Pei YP, Torres VE, Somlo S. J Clin Invest. 2017 May 1;127(5):1772-1785. doi: 10.1172/JCI90129. Epub 2017 Apr 4. PubMed |
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| The miR-25-93-106b cluster regulates tumor metastasis and immune evasion via modulation of CXCL12 and PD-L1. Cioffi M, Trabulo SM, Vallespinos M, Raj D, Kheir TB, Lin ML, Begum J, Baker AM, Amgheib A, Saif J, Perez M, Soriano J, Desco M, Gomez-Gaviro MV, Cusso L, Megias D, Aicher A, Heeschen C. Oncotarget. 2017 Mar 28;8(13):21609-21625. doi: 10.18632/oncotarget.15450. PubMed |
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| Prominin-1 Is a Novel Regulator of Autophagy in the Human Retinal Pigment Epithelium. Bhattacharya S, Yin J, Winborn CS, Zhang Q, Yue J, Chaum E. Invest Ophthalmol Vis Sci. 2017 Apr 1;58(4):2366-2387. doi: 10.1167/iovs.16-21162. PubMed |
| Hepatitis C Virus Indirectly Disrupts DNA Damage-Induced p53 Responses by Activating Protein Kinase R. Mitchell JK, Midkiff BR, Israelow B, Evans MJ, Lanford RE, Walker CM, Lemon SM, McGivern DR. MBio. 2017 Apr 25;8(2). pii: e00121-17. doi: 10.1128/mBio.00121-17. PubMed |
| Sortilin and retromer mediate retrograde transport of Glut4 in 3T3-L1 adipocytes. Pan X, Zaarur N, Singh M, Morin P, Kandror KV. Mol Biol Cell. 2017 Jun 15;28(12):1667-1675. doi: 10.1091/mbc.E16-11-0777. Epub 2017 Apr 27. PubMed |
| Endophilin B2 facilitates endosome maturation in response to growth factor stimulation, autophagy induction, and influenza A virus infection. Serfass JM, Takahashi Y, Zhou Z, Kawasawa YI, Liu Y, Tsotakos N, Young MM, Tang Z, Yang L, Atkinson JM, Chroneos ZC, Wang HG. J Biol Chem. 2017 Jun 16;292(24):10097-10111. doi: 10.1074/jbc.M117.792747. Epub 2017 Apr 28. PubMed |
| A Novel Agonist of the TRIF Pathway Induces a Cellular State Refractory to Replication of Zika, Chikungunya, and Dengue Viruses. Pryke KM, Abraham J, Sali TM, Gall BJ, Archer I, Liu A, Bambina S, Baird J, Gough M, Chakhtoura M, Haddad EK, Kirby IT, Nilsen A, Streblow DN, Hirsch AJ, Smith JL, DeFilippis VR. MBio. 2017 May 2;8(3). pii: e00452-17. doi: 10.1128/mBio.00452-17. PubMed |
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| Linear ubiquitination of cytosolic Salmonella Typhimurium activates NF-kappaB and restricts bacterial proliferation. van Wijk SJL, Fricke F, Herhaus L, Gupta J, Hotte K, Pampaloni F, Grumati P, Kaulich M, Sou YS, Komatsu M, Greten FR, Fulda S, Heilemann M, Dikic I. Nat Microbiol. 2017 May 8;2:17066. doi: 10.1038/nmicrobiol.2017.66. PubMed |
| p53 Maintains Baseline Expression of Multiple Tumor Suppressor Genes. Pappas K, Xu J, Zairis S, Resnick-Silverman L, Abate F, Steinbach N, Ozturk S, Saal LH, Su T, Cheung P, Schmidt H, Aaronson S, Hibshoosh H, Manfredi J, Rabadan R, Parsons R. Mol Cancer Res. 2017 May 8. doi: 10.1158/1541-7786.MCR-17-0089. PubMed |
| Type I and Type III Interferons Display Different Dependency on Mitogen-Activated Protein Kinases to Mount an Antiviral State in the Human Gut. Pervolaraki K, Stanifer ML, Munchau S, Renn LA, Albrecht D, Kurzhals S, Senis E, Grimm D, Schroder-Braunstein J, Rabin RL, Boulant S. Front Immunol. 2017 Apr 21;8:459. doi: 10.3389/fimmu.2017.00459. eCollection 2017. PubMed |
| IDH Mutation, Competitive Inhibition of FTO, and RNA Methylation. Elkashef SM, Lin AP, Myers J, Sill H, Jiang D, Dahia PLM, Aguiar RCT. Cancer Cell. 2017 May 8;31(5):619-620. doi: 10.1016/j.ccell.2017.04.001. PubMed |
| CHD4 Has Oncogenic Functions in Initiating and Maintaining Epigenetic Suppression of Multiple Tumor Suppressor Genes. Xia L, Huang W, Bellani M, Seidman MM, Wu K, Fan D, Nie Y, Cai Y, Zhang YW, Yu LR, Li H, Zahnow CA, Xie W, Chiu Yen RW, Rassool FV, Baylin SB. Cancer Cell. 2017 May 8;31(5):653-668.e7. doi: 10.1016/j.ccell.2017.04.005. PubMed |
| Intratumoural heterogeneity generated by Notch signalling promotes small-cell lung cancer. Lim JS, Ibaseta A, Fischer MM, Cancilla B, O'Young G, Cristea S, Luca VC, Yang D, Jahchan NS, Hamard C, Antoine M, Wislez M, Kong C, Cain J, Liu YW, Kapoun AM, Garcia KC, Hoey T, Murriel CL, Sage J. Nature. 2017 May 18;545(7654):360-364. doi: 10.1038/nature22323. Epub 2017 May 10. PubMed |
| Integrase-Deficient Lentiviral Vector as an All-in-One Platform for Highly Efficient CRISPR/Cas9-Mediated Gene Editing. Ortinski PI, O'Donovan B, Dong X, Kantor B. Mol Ther Methods Clin Dev. 2017 Apr 19;5:153-164. doi: 10.1016/j.omtm.2017.04.002. eCollection 2017 Jun 16. PubMed |
| E2F1 inhibits circulating cholesterol clearance by regulating Pcsk9 expression in the liver. Lai Q, Giralt A, Le May C, Zhang L, Cariou B, Denechaud PD, Fajas L. JCI Insight. 2017 May 18;2(10). pii: 89729. doi: 10.1172/jci.insight.89729. PubMed |
| Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function. Sakamaki JI, Wilkinson S, Hahn M, Tasdemir N, O'Prey J, Clark W, Hedley A, Nixon C, Long JS, New M, Van Acker T, Tooze SA, Lowe SW, Dikic I, Ryan KM. Mol Cell. 2017 May 18;66(4):517-532.e9. doi: 10.1016/j.molcel.2017.04.027. PubMed |
| Imatinib induces autophagy via upregulating XIAP in GIST882 cells. Xie Q, Lin Q, Li D, Chen J. Biochem Biophys Res Commun. 2017 Jul 8;488(4):584-589. doi: 10.1016/j.bbrc.2017.05.096. Epub 2017 May 18. PubMed |
| A novel isoform of TET1 that lacks a CXXC domain is overexpressed in cancer. Good CR, Madzo J, Patel B, Maegawa S, Engel N, Jelinek J, Issa JJ. Nucleic Acids Res. 2017 May 22. doi: 10.1093/nar/gkx435. PubMed |
| cGAS is essential for cellular senescence. Yang H, Wang H, Ren J, Chen Q, Chen ZJ. Proc Natl Acad Sci U S A. 2017 Jun 6;114(23):E4612-E4620. doi: 10.1073/pnas.1705499114. Epub 2017 May 22. PubMed |
| Heparan Sulfate Proteoglycan Is an Important Attachment Factor for Cell Entry of Akabane and Schmallenberg Viruses. Murakami S, Takenaka-Uema A, Kobayashi T, Kato K, Shimojima M, Palmarini M, Horimoto T. J Virol. 2017 Jul 12;91(15). pii: e00503-17. doi: 10.1128/JVI.00503-17. Print 2017 Aug 1. PubMed |
| Systematic discovery of mutation-specific synthetic lethals by mining pan-cancer human primary tumor data. Sinha S, Thomas D, Chan S, Gao Y, Brunen D, Torabi D, Reinisch A, Hernandez D, Chan A, Rankin EB, Bernards R, Majeti R, Dill DL. Nat Commun. 2017 May 31;8:15580. doi: 10.1038/ncomms15580. PubMed |
| Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals. Quiros PM, Prado MA, Zamboni N, D'Amico D, Williams RW, Finley D, Gygi SP, Auwerx J. J Cell Biol. 2017 Jul 3;216(7):2027-2045. doi: 10.1083/jcb.201702058. Epub 2017 May 31. PubMed |
| Hepatitis B virus X protein promotes CREB-mediated activation of miR-3188 and Notch signaling in hepatocellular carcinoma. Zhou SJ, Deng YL, Liang HF, Jaoude JC, Liu FY. Cell Death Differ. 2017 Sep;24(9):1577-1587. doi: 10.1038/cdd.2017.87. Epub 2017 Jun 2. PubMed |
| Monitoring of the spatial and temporal dynamics of BER/SSBR pathway proteins, including MYH, UNG2, MPG, NTH1 and NEIL1-3, during DNA replication. Bjoras KO, Sousa MML, Sharma A, Fonseca DM, Sogaard CK, Bjoras M, Otterlei M. Nucleic Acids Res. 2017 May 29. doi: 10.1093/nar/gkx476. PubMed |
| Epigenetic silencing of IRF1 dysregulates type III interferon responses to respiratory virus infection in epithelial to mesenchymal transition. Yang J, Tian B, Sun H, Garofalo RP, Brasier AR. Nat Microbiol. 2017 Jun 5;2:17086. doi: 10.1038/nmicrobiol.2017.86. PubMed |
| Regulator of Calcineurin 1 Gene Isoform 4, Down-regulated in Hepatocellular Carcinoma, Prevents Proliferation, Migration, and Invasive Activity of Cancer Cells and Metastasis of Orthotopic Tumors by Inhibiting Nuclear Translocation of NFAT1. Jin H, Wang C, Jin G, Ruan H, Gu D, Wei L, Wang H, Wang N, Arunachalam E, Zhang Y, Deng X, Yang C, Xiong Y, Feng H, Yao M, Fang J, Gu J, Cong W, Qin W. Gastroenterology. 2017 Sep;153(3):799-811.e33. doi: 10.1053/j.gastro.2017.05.045. Epub 2017 Jun 2. PubMed |
| ERRalpha Maintains Mitochondrial Oxidative Metabolism and Constitutes an Actionable Target in PGC1alpha-Elevated Melanomas. Luo C, Balsa E, Thomas A, Hatting M, Jedrychowski M, Gygi SP, Widlund HR, Puigserver P. Mol Cancer Res. 2017 Jun 8. doi: 10.1158/1541-7786.MCR-17-0143. PubMed |
| Simultaneous Knockout of CXCR4 and CCR5 Genes in CD4+ T Cells via CRISPR/Cas9 Confers Resistance to Both X4- and R5-Tropic Human Immunodeficiency Virus Type 1 Infection. Yu S, Yao Y, Xiao H, Li J, Liu Q, Yang Y, Adah D, Lu J, Zhao S, Qin L, Chen X. Hum Gene Ther. 2017 Jun 9. doi: 10.1089/hum.2017.032. PubMed |
| Sphingosine 1-Phosphate Lyase Enhances the Activation of IKKepsilon To Promote Type I IFN-Mediated Innate Immune Responses to Influenza A Virus Infection. Vijayan M, Xia C, Song YE, Ngo H, Studstill CJ, Drews K, Fox TE, Johnson MC, Hiscott J, Kester M, Alexander S, Hahm B. J Immunol. 2017 Jul 15;199(2):677-687. doi: 10.4049/jimmunol.1601959. Epub 2017 Jun 9. PubMed |
Oncogenic K-Ras upregulates ITGA6 expression via FOSL1 to induce anoikis resistance and synergizes with alphaV-Class integrins to promote EMT.
Zhang K, Myllymaki SM, Gao P, Devarajan R, Kytola V, Nykter M, Wei GH, Manninen A.
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| Non-glycanated Decorin Is a Drug Target on Human Adipose Stromal Cells. Daquinag AC, Dadbin A, Snyder B, Wang X, Sahin AA, Ueno NT, Kolonin MG. Mol Ther Oncolytics. 2017 May 17;6:1-9. doi: 10.1016/j.omto.2017.05.003. eCollection 2017 Sep 15. PubMed |
| A novel combination treatment targeting BCL-XL and MCL1 for KRAS/BRAF-mutated and BCL2L1-amplified colorectal cancers. Cho SY, Han JY, Na D, Kang W, Lee A, Kim J, Lee J, Min S, Kang J, Chae J, Kim JI, Park H, Lee WS, Lee C. Mol Cancer Ther. 2017 Jun 13. pii: molcanther.0735.2016. doi: 10.1158/1535-7163.MCT-16-0735. PubMed |
| Activation of the ATF2/CREB-PGC-1alpha pathway by metformin leads to dopaminergic neuroprotection. Kang H, Khang R, Ham S, Jeong GR, Kim H, Jo M, Lee BD, Lee YI, Jo A, Park C, Kim H, Seo J, Paek SH, Lee YS, Choi JY, Lee Y, Shin JH. Oncotarget. 2017 Jul 25;8(30):48603-48618. doi: 10.18632/oncotarget.18122. PubMed |
| Germline factor DDX4 functions in blood-derived cancer cell phenotypes. Schudrowitz N, Takagi S, Wessel GM, Yajima M. Cancer Sci. 2017 Jun 14. doi: 10.1111/cas.13299. PubMed |
| ERF mutations reveal a balance of ETS factors controlling prostate oncogenesis. Bose R, Karthaus WR, Armenia J, Abida W, Iaquinta PJ, Zhang Z, Wongvipat J, Wasmuth EV, Shah N, Sullivan PS, Doran MG, Wang P, Patruno A, Zhao Y, Zheng D, Schultz N, Sawyers CL. Nature. 2017 Jun 29;546(7660):671-675. doi: 10.1038/nature22820. Epub 2017 Jun 14. PubMed |
| CRISPR/Cas9-mediated genome editing induces exon skipping by alternative splicing or exon deletion. Mou H, Smith JL, Peng L, Yin H, Moore J, Zhang XO, Song CQ, Sheel A, Wu Q, Ozata DM, Li Y, Anderson DG, Emerson CP, Sontheimer EJ, Moore MJ, Weng Z, Xue W. Genome Biol. 2017 Jun 14;18(1):108. doi: 10.1186/s13059-017-1237-8. PubMed |
| Correction of the Exon 2 Duplication in DMD Myoblasts by a Single CRISPR/Cas9 System. Lattanzi A, Duguez S, Moiani A, Izmiryan A, Barbon E, Martin S, Mamchaoui K, Mouly V, Bernardi F, Mavilio F, Bovolenta M. Mol Ther Nucleic Acids. 2017 Jun 16;7:11-19. doi: 10.1016/j.omtn.2017.02.004. Epub 2017 Feb 10. PubMed |
| A therapeutic T cell receptor mimic antibody targets tumor-associated PRAME peptide/HLA-I antigens. Chang AY, Dao T, Gejman RS, Jarvis CA, Scott A, Dubrovsky L, Mathias MD, Korontsvit T, Zakhaleva V, Curcio M, Hendrickson RC, Liu C, Scheinberg DA. J Clin Invest. 2017 Jun 30;127(7):2705-2718. doi: 10.1172/JCI92335. Epub 2017 Jun 19. PubMed |
| RBM25 is a global splicing factor promoting inclusion of alternatively spliced exons and is itself regulated by lysine mono-methylation. Carlson SM, Soulette CM, Yang Z, Elias JE, Brooks AN, Gozani O. J Biol Chem. 2017 Jun 27. pii: jbc.M117.784371. doi: 10.1074/jbc.M117.784371. PubMed |
| CRISPR/Cas9 targeting of GPRC6A suppresses prostate cancer tumorigenesis in a human xenograft model. Ye R, Pi M, Cox JV, Nishimoto SK, Quarles LD. J Exp Clin Cancer Res. 2017 Jun 28;36(1):90. doi: 10.1186/s13046-017-0561-x. PubMed |
| Mechanical cue-induced YAP instructs Skp2-dependent cell cycle exit and oncogenic signaling. Jang W, Kim T, Koo JS, Kim SK, Lim DS. EMBO J. 2017 Sep 1;36(17):2510-2528. doi: 10.15252/embj.201696089. Epub 2017 Jul 3. PubMed |
| Tumor Antigen and Receptor Densities Regulate Efficacy of a Chimeric Antigen Receptor Targeting Anaplastic Lymphoma Kinase. Walker AJ, Majzner RG, Zhang L, Wanhainen K, Long AH, Nguyen SM, Lopomo P, Vigny M, Fry TJ, Orentas RJ, Mackall CL. Mol Ther. 2017 Jul 1. pii: S1525-0016(17)30270-8. doi: 10.1016/j.ymthe.2017.06.008. PubMed |
| Transcription elongation factors represent in vivo cancer dependencies in glioblastoma. Miller TE, Liau BB, Wallace LC, Morton AR, Xie Q, Dixit D, Factor DC, Kim LJY, Morrow JJ, Wu Q, Mack SC, Hubert CG, Gillespie SM, Flavahan WA, Hoffmann T, Thummalapalli R, Hemann MT, Paddison PJ, Horbinski CM, Zuber J, Scacheri PC, Bernstein BE, Tesar PJ, Rich JN. Nature. 2017 Jul 20;547(7663):355-359. doi: 10.1038/nature23000. Epub 2017 Jul 5. PubMed |
| Argonaute Utilization for miRNA Silencing Is Determined by Phosphorylation-Dependent Recruitment of LIM-Domain-Containing Proteins. Bridge KS, Shah KM, Li Y, Foxler DE, Wong SCK, Miller DC, Davidson KM, Foster JG, Rose R, Hodgkinson MR, Ribeiro PS, Aboobaker AA, Yashiro K, Wang X, Graves PR, Plevin MJ, Lagos D, Sharp TV. Cell Rep. 2017 Jul 5;20(1):173-187. doi: 10.1016/j.celrep.2017.06.027. PubMed |
| Crosstalk between NRF2 and HIPK2 shapes cytoprotective responses. Torrente L, Sanchez C, Moreno R, Chowdhry S, Cabello P, Isono K, Koseki H, Honda T, Hayes JD, Dinkova-Kostova AT, de la Vega L. Oncogene. 2017 Jul 10. doi: 10.1038/onc.2017.221. PubMed |
| DGAT1-Dependent Lipid Droplet Biogenesis Protects Mitochondrial Function during Starvation-Induced Autophagy. Nguyen TB, Louie SM, Daniele JR, Tran Q, Dillin A, Zoncu R, Nomura DK, Olzmann JA. Dev Cell. 2017 Jul 10;42(1):9-21.e5. doi: 10.1016/j.devcel.2017.06.003. PubMed |
| A proteomic analysis of LRRK2 binding partners reveals interactions with multiple signaling components of the WNT/PCP pathway. Salasova A, Yokota C, Potesil D, Zdrahal Z, Bryja V, Arenas E. Mol Neurodegener. 2017 Jul 11;12(1):54. doi: 10.1186/s13024-017-0193-9. PubMed |
| A Role for Mitochondrial Translation in Promotion of Viability in K-Ras Mutant Cells. Martin TD, Cook DR, Choi MY, Li MZ, Haigis KM, Elledge SJ. Cell Rep. 2017 Jul 11;20(2):427-438. doi: 10.1016/j.celrep.2017.06.061. PubMed |
| Manipulation of nuclear architecture through CRISPR-mediated chromosomal looping. Morgan SL, Mariano NC, Bermudez A, Arruda NL, Wu F, Luo Y, Shankar G, Jia L, Chen H, Hu JF, Hoffman AR, Huang CC, Pitteri SJ, Wang KC. Nat Commun. 2017 Jul 13;8:15993. doi: 10.1038/ncomms15993. PubMed |
| VE-Cadherin Phosphorylation Regulates Endothelial Fluid Shear Stress Responses through the Polarity Protein LGN. Conway DE, Coon BG, Budatha M, Arsenovic PT, Orsenigo F, Wessel F, Zhang J, Zhuang Z, Dejana E, Vestweber D, Schwartz MA. Curr Biol. 2017 Jul 24;27(14):2219-2225.e5. doi: 10.1016/j.cub.2017.06.020. Epub 2017 Jul 14. PubMed |
| Acylglycerol Kinase Mutated in Sengers Syndrome Is a Subunit of the TIM22 Protein Translocase in Mitochondria. Vukotic M, Nolte H, Konig T, Saita S, Ananjew M, Kruger M, Tatsuta T, Langer T. Mol Cell. 2017 Aug 3;67(3):471-483.e7. doi: 10.1016/j.molcel.2017.06.013. Epub 2017 Jul 14. PubMed |
| Cytosolic interaction of type III human CD38 with CIB1 modulates cellular cyclic ADP-ribose levels. Liu J, Zhao YJ, Li WH, Hou YN, Li T, Zhao ZY, Fang C, Li SL, Lee HC. Proc Natl Acad Sci U S A. 2017 Jul 18. pii: 1703718114. doi: 10.1073/pnas.1703718114. PubMed |
| Disrupted apical exocytosis of cargo vesicles causes enteropathy in FHL5 patients with Munc18-2 mutations. Vogel GF, van Rijn JM, Krainer IM, Janecke AR, Posovszky C, Cohen M, Searle C, Jantchou P, Escher JC, Patey N, Cutz E, Muller T, Middendorp S, Hess MW, Huber LA. JCI Insight. 2017 Jul 20;2(14). pii: 94564. doi: 10.1172/jci.insight.94564. PubMed |
| A time-resolved molecular map of the macrophage response to VSV infection. Kandasamy RK, Vladimer GI, Snijder B, Muller AC, Rebsamen M, Bigenzahn JW, Moskovskich A, Sabler M, Stefanovic A, Scorzoni S, Bruckner M, Penz T, Cleary C, Kralovics R, Colinge J, Bennett KL, Superti-Furga G. NPJ Syst Biol Appl. 2016 Oct 27;2:16027. doi: 10.1038/npjsba.2016.27. eCollection 2016. PubMed |
| Autophagy inhibition reduces chemoresistance and tumorigenic potential of human ovarian cancer stem cells. Pagotto A, Pilotto G, Mazzoldi EL, Nicoletto MO, Frezzini S, Pasto A, Amadori A. Cell Death Dis. 2017 Jul 20;8(7):e2943. doi: 10.1038/cddis.2017.327. PubMed |
| Deletion of transcription factor binding motifs using the CRISPR/spCas9 system in the beta-globin LCR. Kim YW, Kim A. Biosci Rep. 2017 Jul 20. pii: BSR20170976. doi: 10.1042/BSR20170976. PubMed |
| A CRISPR Resource for Individual, Combinatorial, or Multiplexed Gene Knockout. Erard N, Knott SRV, Hannon GJ. Mol Cell. 2017 Jul 20;67(2):348-354.e4. doi: 10.1016/j.molcel.2017.06.030. PubMed |
| BOK displays cell death-independent tumor suppressor activity in non-small-cell lung carcinoma. Moravcikova E, Krepela E, Donnenberg VS, Donnenberg AD, Benkova K, Rabachini T, Fernandez-Marrero Y, Bachmann D, Kaufmann T. Int J Cancer. 2017 Nov 15;141(10):2050-2061. doi: 10.1002/ijc.30906. Epub 2017 Aug 7. PubMed |
| Influenza virus recruits host protein kinase C to control assembly and activity of its replication machinery. Mondal A, Dawson AR, Potts GK, Freiberger EC, Baker SF, Moser LA, Bernard KA, Coon JJ, Mehle A. Elife. 2017 Jul 31;6. pii: 26910. doi: 10.7554/eLife.26910. PubMed |
| The tetraspanin CD9 facilitates MERS-coronavirus entry by scaffolding host cell receptors and proteases. Earnest JT, Hantak MP, Li K, McCray PB Jr, Perlman S, Gallagher T. PLoS Pathog. 2017 Jul 31;13(7):e1006546. doi: 10.1371/journal.ppat.1006546. eCollection 2017 Jul. PubMed |
| FBW7 Loss Promotes Chromosomal Instability and Tumorigenesis via Cyclin E1/CDK2-Mediated Phosphorylation of CENP-A. Takada M, Zhang W, Suzuki A, Kuroda TS, Yu Z, Inuzuka H, Gao D, Wan L, Zhuang M, Hu L, Zhai B, Fry CJ, Bloom K, Li G, Karpen GH, Wei W, Zhang Q. Cancer Res. 2017 Sep 15;77(18):4881-4893. doi: 10.1158/0008-5472.CAN-17-1240. Epub 2017 Jul 31. PubMed |
| A20 restores phorbol ester-induced differentiation of THP-1 cells in the absence of nuclear factor-kappaB activation. Osako M, Itsumi M, Yamaguchi H, Takeuchi H, Yamaoka S. J Cell Biochem. 2018 Feb;119(2):1475-1487. doi: 10.1002/jcb.26308. Epub 2017 Aug 28. PubMed |
| Interaction between von Hippel-Lindau Protein and Fatty Acid Synthase Modulates Hypoxia Target Gene Expression. Sun W, Kato H, Kitajima S, Lee KL, Gradin K, Okamoto T, Poellinger L. Sci Rep. 2017 Aug 3;7(1):7190. doi: 10.1038/s41598-017-05685-3. PubMed |
| Phospho-H1 Decorates the Inter-chromatid Axis and Is Evicted along with Shugoshin by SET during Mitosis. Krishnan S, Smits AH, Vermeulen M, Reinberg D. Mol Cell. 2017 Aug 17;67(4):579-593.e6. doi: 10.1016/j.molcel.2017.07.008. Epub 2017 Aug 3. PubMed |
| Genome-scale activation screen identifies a lncRNA locus regulating a gene neighbourhood. Joung J, Engreitz JM, Konermann S, Abudayyeh OO, Verdine VK, Aguet F, Gootenberg JS, Sanjana NE, Wright JB, Fulco CP, Tseng YY, Yoon CH, Boehm JS, Lander ES, Zhang F. Nature. 2017 Aug 11. doi: 10.1038/nature23451. PubMed |
| Effects of gene knockdown of CNP on ventricular remodeling after myocardial ischemia-reperfusion injury through NPRB/Cgmp signaling pathway in rats. Wu LH, Zhang Q, Zhang S, Meng LY, Wang YC, Sheng CJ. J Cell Biochem. 2018 Feb;119(2):1804-1818. doi: 10.1002/jcb.26341. Epub 2017 Sep 18. PubMed |
| Atg2A/B deficiency switches cytoprotective autophagy to non-canonical caspase-8 activation and apoptosis. Tang Z, Takahashi Y, Chen C, Liu Y, He H, Tsotakos N, Serfass JM, Gebru MT, Chen H, Young MM, Wang HG. Cell Death Differ. 2017 Dec;24(12):2127-2138. doi: 10.1038/cdd.2017.133. Epub 2017 Aug 11. PubMed |
| Exploiting Radiation-Induced Signaling to Increase the Susceptibility of Resistant Cancer Cells to Targeted Drugs: AKT and mTOR Inhibitors as an Example. Eke I, Makinde AY, Aryankalayil MJ, Sandfort V, Palayoor ST, Rath BH, Liotta L, Pierobon M, Petricoin EF, Brown MF, Stommel JM, Ahmed MM, Coleman CN. Mol Cancer Ther. 2018 Feb;17(2):355-367. doi: 10.1158/1535-7163.MCT-17-0262. Epub 2017 Aug 11. PubMed |
| Bisphosphoglycerate mutase controls serine pathway flux via 3-phosphoglycerate. Oslund RC, Su X, Haugbro M, Kee JM, Esposito M, David Y, Wang B, Ge E, Perlman DH, Kang Y, Muir TW, Rabinowitz JD. Nat Chem Biol. 2017 Oct;13(10):1081-1087. doi: 10.1038/nchembio.2453. Epub 2017 Aug 7. PubMed |
| Intrinsic BET inhibitor resistance in SPOP-mutated prostate cancer is mediated by BET protein stabilization and AKT-mTORC1 activation. Zhang P, Wang D, Zhao Y, Ren S, Gao K, Ye Z, Wang S, Pan CW, Zhu Y, Yan Y, Yang Y, Wu D, He Y, Zhang J, Lu D, Liu X, Yu L, Zhao S, Li Y, Lin D, Wang Y, Wang L, Chen Y, Sun Y, Wang C, Huang H. Nat Med. 2017 Sep;23(9):1055-1062. doi: 10.1038/nm.4379. Epub 2017 Aug 14. PubMed |
| Identification of CMTM6 and CMTM4 as PD-L1 protein regulators. Mezzadra R, Sun C, Jae LT, Gomez-Eerland R, de Vries E, Wu W, Logtenberg MEW, Slagter M, Rozeman EA, Hofland I, Broeks A, Horlings HM, Wessels LFA, Blank CU, Xiao Y, Heck AJR, Borst J, Brummelkamp TR, Schumacher TNM. Nature. 2017 Sep 7;549(7670):106-110. doi: 10.1038/nature23669. Epub 2017 Aug 16. PubMed |
| MTG16 is a tumor suppressor in colitis-associated carcinoma. McDonough EM, Barrett CW, Parang B, Mittal MK, Smith JJ, Bradley AM, Choksi YA, Coburn LA, Short SP, Thompson JJ, Zhang B, Poindexter SV, Fischer MA, Chen X, Li J, Revetta FL, Naik R, Washington MK, Rosen MJ, Hiebert SW, Wilson KT, Williams CS. JCI Insight. 2017 Aug 17;2(16). pii: 78210. doi: 10.1172/jci.insight.78210. PubMed |
| CRISPR/Cas9 editing reveals novel mechanisms of clustered microRNA regulation and function. Lataniotis L, Albrecht A, Kok FO, Monfries CAL, Benedetti L, Lawson ND, Hughes SM, Steinhofel K, Mayr M, Zampetaki A. Sci Rep. 2017 Aug 17;7(1):8585. doi: 10.1038/s41598-017-09268-0. PubMed |
| Synergy of WEE1 and mTOR Inhibition in Mutant KRAS-Driven Lung Cancers. Hai J, Liu S, Bufe L, Do K, Chen T, Wang X, Ng C, Li S, Tsao MS, Shapiro GI, Wong KK. Clin Cancer Res. 2017 Nov 15;23(22):6993-7005. doi: 10.1158/1078-0432.CCR-17-1098. Epub 2017 Aug 18. PubMed |
| LRRK2 promotes the activation of NLRC4 inflammasome during Salmonella Typhimurium infection. Liu W, Liu X, Li Y, Zhao J, Liu Z, Hu Z, Wang Y, Yao Y, Miller AW, Su B, Cookson MR, Li X, Kang Z. J Exp Med. 2017 Oct 2;214(10):3051-3066. doi: 10.1084/jem.20170014. Epub 2017 Aug 18. PubMed |
| Inactivation of Capicua in adult mice causes T-cell lymphoblastic lymphoma. Simon-Carrasco L, Grana O, Salmon M, Jacob HKC, Gutierrez A, Jimenez G, Drosten M, Barbacid M. Genes Dev. 2017 Jul 15;31(14):1456-1468. doi: 10.1101/gad.300244.117. Epub 2017 Aug 21. PubMed |
| Specific Expression of Interferon-gamma Induced by Synergistic Activation Mediator-Derived Systems Activates Innate Immunity and Inhibits Tumorigenesis. Liu S, Yu X, Wang Q, Liu Z, Xiao Q, Hou P, Hu Y, Hou W, Yang Z, Guo D, Chen S. J Microbiol Biotechnol. 2017 Oct 28;27(10):1855-1866. doi: 10.4014/jmb.1705.05081. PubMed |
| Mitochondrial permeabilization engages NF-kappaB-dependent anti-tumour activity under caspase deficiency. Giampazolias E, Zunino B, Dhayade S, Bock F, Cloix C, Cao K, Roca A, Lopez J, Ichim G, Proics E, Rubio-Patino C, Fort L, Yatim N, Woodham E, Orozco S, Taraborrelli L, Peltzer N, Lecis D, Machesky L, Walczak H, Albert ML, Milling S, Oberst A, Ricci JE, Ryan KM, Blyth K, Tait SWG. Nat Cell Biol. 2017 Sep;19(9):1116-1129. doi: 10.1038/ncb3596. Epub 2017 Aug 28. PubMed |
| Degradation of PHLPP2 by KCTD17, via a Glucagon-Dependent Pathway, Promotes Hepatic Steatosis. Kim K, Ryu D, Dongiovanni P, Ozcan L, Nayak S, Ueberheide B, Valenti L, Auwerx J, Pajvani UB. Gastroenterology. 2017 Dec;153(6):1568-1580.e10. doi: 10.1053/j.gastro.2017.08.039. Epub 2017 Aug 30. PubMed |
| Global Inhibition with Specific Activation: How p53 and MYC Redistribute the Transcriptome in the DNA Double-Strand Break Response. Porter JR, Fisher BE, Baranello L, Liu JC, Kambach DM, Nie Z, Koh WS, Luo J, Stommel JM, Levens D, Batchelor E. Mol Cell. 2017 Sep 21;67(6):1013-1025.e9. doi: 10.1016/j.molcel.2017.07.028. Epub 2017 Aug 31. PubMed |
| Salmonella Utilizes Zinc To Subvert Antimicrobial Host Defense of Macrophages via Modulation of NF-kappaB Signaling. Wu A, Tymoszuk P, Haschka D, Heeke S, Dichtl S, Petzer V, Seifert M, Hilbe R, Sopper S, Talasz H, Bumann D, Lass-Florl C, Theurl I, Zhang K, Weiss G. Infect Immun. 2017 Nov 17;85(12). pii: IAI.00418-17. doi: 10.1128/IAI.00418-17. Print 2017 Dec. PubMed |
| Human Herpesvirus 8 Interleukin-6 Interacts with Calnexin Cycle Components and Promotes Protein Folding. Chen D, Xiang Q, Nicholas J. J Virol. 2017 Oct 27;91(22). pii: JVI.00965-17. doi: 10.1128/JVI.00965-17. Print 2017 Nov 15. PubMed |
Kinesin superfamily protein Kif26b links Wnt5a-Ror signaling to the control of cell and tissue behaviors in vertebrates.
Susman MW, Karuna EP, Kunz RC, Gujral TS, Cantu AV, Choi SS, Jong BY, Okada K, Scales MK, Hum J, Hu LS, Kirschner MW, Nishinakamura R, Yamada S, Laird DJ, Jao LE, Gygi SP, Greenberg ME, Ho HH.
Elife. 2017 Sep 8;6. pii: e26509. doi: 10.7554/eLife.26509.
PubMed
Associated Plasmids |
| Centriole triplet microtubules are required for stable centriole formation and inheritance in human cells. Wang JT, Kong D, Hoerner CR, Loncarek J, Stearns T. Elife. 2017 Sep 14;6. pii: 29061. doi: 10.7554/eLife.29061. PubMed |
| Targeted Disruption of V600E-Mutant BRAF Gene by CRISPR-Cpf1. Yang M, Wei H, Wang Y, Deng J, Tang Y, Zhou L, Guo G, Tong A. Mol Ther Nucleic Acids. 2017 Sep 15;8:450-458. doi: 10.1016/j.omtn.2017.05.009. Epub 2017 May 17. PubMed |
| mTOR Inhibition Restores Amino Acid Balance in Cells Dependent on Catabolism of Extracellular Protein. Nofal M, Zhang K, Han S, Rabinowitz JD. Mol Cell. 2017 Sep 21;67(6):936-946.e5. doi: 10.1016/j.molcel.2017.08.011. Epub 2017 Sep 14. PubMed |
| ER-associated degradation is required for vasopressin prohormone processing and systemic water homeostasis. Shi G, Somlo DRM, Kim GH, Prescianotto-Baschong C, Sun S, Beuret N, Long Q, Rutishauser J, Arvan P, Spiess M, Qi L. J Clin Invest. 2017 Oct 2;127(10):3897-3912. doi: 10.1172/JCI94771. Epub 2017 Sep 18. PubMed |
| Priming and Activation of Inflammasome by Canarypox Virus Vector ALVAC via the cGAS/IFI16-STING-Type I IFN Pathway and AIM2 Sensor. Liu F, Niu Q, Fan X, Liu C, Zhang J, Wei Z, Hou W, Kanneganti TD, Robb ML, Kim JH, Michael NL, Sun J, Soong L, Hu H. J Immunol. 2017 Nov 1;199(9):3293-3305. doi: 10.4049/jimmunol.1700698. Epub 2017 Sep 25. PubMed |
| PHGDH as a Key Enzyme for Serine Biosynthesis in HIF2alpha-Targeting Therapy for Renal Cell Carcinoma. Yoshino H, Nohata N, Miyamoto K, Yonemori M, Sakaguchi T, Sugita S, Itesako T, Kofuji S, Nakagawa M, Dahiya R, Enokida H. Cancer Res. 2017 Nov 15;77(22):6321-6329. doi: 10.1158/0008-5472.CAN-17-1589. Epub 2017 Sep 26. PubMed |
| CG dinucleotide suppression enables antiviral defence targeting non-self RNA. Takata MA, Goncalves-Carneiro D, Zang TM, Soll SJ, York A, Blanco-Melo D, Bieniasz PD. Nature. 2017 Oct 5;550(7674):124-127. doi: 10.1038/nature24039. Epub 2017 Sep 27. PubMed |
| Genome-Wide CRISPR Screen for Essential Cell Growth Mediators in Mutant KRAS Colorectal Cancers. Yau EH, Kummetha IR, Lichinchi G, Tang R, Zhang Y, Rana TM. Cancer Res. 2017 Nov 15;77(22):6330-6339. doi: 10.1158/0008-5472.CAN-17-2043. Epub 2017 Sep 27. PubMed |
| Salt-inducible kinases (SIK) inhibition reduces RANKL-induced osteoclastogenesis. Lombardi MS, Gillieron C, Berkelaar M, Gabay C. PLoS One. 2017 Oct 3;12(10):e0185426. doi: 10.1371/journal.pone.0185426. eCollection 2017. PubMed |
| Implications of FGF19 on sorafenib-mediated nitric oxide production in hepatocellular carcinoma cells - a short report. Gao L, Shay C, Lv F, Wang X, Teng Y. Cell Oncol (Dordr). 2018 Feb;41(1):85-91. doi: 10.1007/s13402-017-0354-4. Epub 2017 Oct 5. PubMed |
| CRISPR-Cas9-mediated functional dissection of 3'-UTRs. Zhao W, Siegel D, Biton A, Tonqueze OL, Zaitlen N, Ahituv N, Erle DJ. Nucleic Acids Res. 2017 Oct 13;45(18):10800-10810. doi: 10.1093/nar/gkx675. PubMed |
| Innate immune recognition of double-stranded RNA triggers increased expression of NKG2D ligands after virus infection. Esteso G, Guerra S, Vales-Gomez M, Reyburn HT. J Biol Chem. 2017 Dec 15;292(50):20472-20480. doi: 10.1074/jbc.M117.818393. Epub 2017 Oct 6. PubMed |
| Replication defective viral genomes exploit a cellular pro-survival mechanism to establish paramyxovirus persistence. Xu J, Sun Y, Li Y, Ruthel G, Weiss SR, Raj A, Beiting D, Lopez CB. Nat Commun. 2017 Oct 6;8(1):799. doi: 10.1038/s41467-017-00909-6. PubMed |
| ATF4-Induced Metabolic Reprograming Is a Synthetic Vulnerability of the p62-Deficient Tumor Stroma. Linares JF, Cordes T, Duran A, Reina-Campos M, Valencia T, Ahn CS, Castilla EA, Moscat J, Metallo CM, Diaz-Meco MT. Cell Metab. 2017 Dec 5;26(6):817-829.e6. doi: 10.1016/j.cmet.2017.09.001. Epub 2017 Oct 5. PubMed |
| LAMTOR/Ragulator is a negative regulator of Arl8b- and BORC-dependent late endosomal positioning. Filipek PA, de Araujo MEG, Vogel GF, De Smet CH, Eberharter D, Rebsamen M, Rudashevskaya EL, Kremser L, Yordanov T, Tschaikner P, Furnrohr BG, Lechner S, Dunzendorfer-Matt T, Scheffzek K, Bennett KL, Superti-Furga G, Lindner HH, Stasyk T, Huber LA. J Cell Biol. 2017 Dec 4;216(12):4199-4215. doi: 10.1083/jcb.201703061. Epub 2017 Oct 9. PubMed |
| A Large-Scale RNAi Screen Identifies SGK1 as a Key Survival Kinase for GBM Stem Cells. Kulkarni S, Goel-Bhattacharya S, Sengupta S, Cochran BH. Mol Cancer Res. 2018 Jan;16(1):103-114. doi: 10.1158/1541-7786.MCR-17-0146. Epub 2017 Oct 9. PubMed |
| Androgen Receptor Pathway-Independent Prostate Cancer Is Sustained through FGF Signaling. Bluemn EG, Coleman IM, Lucas JM, Coleman RT, Hernandez-Lopez S, Tharakan R, Bianchi-Frias D, Dumpit RF, Kaipainen A, Corella AN, Yang YC, Nyquist MD, Mostaghel E, Hsieh AC, Zhang X, Corey E, Brown LG, Nguyen HM, Pienta K, Ittmann M, Schweizer M, True LD, Wise D, Rennie PS, Vessella RL, Morrissey C, Nelson PS. Cancer Cell. 2017 Oct 9;32(4):474-489.e6. doi: 10.1016/j.ccell.2017.09.003. PubMed |
| Diverse Viruses Require the Calcium Transporter SPCA1 for Maturation and Spread. Hoffmann HH, Schneider WM, Blomen VA, Scull MA, Hovnanian A, Brummelkamp TR, Rice CM. Cell Host Microbe. 2017 Oct 11;22(4):460-470.e5. doi: 10.1016/j.chom.2017.09.002. PubMed |
| Ebola virus requires phosphatidylinositol (3,5) bisphosphate production for efficient viral entry. Qiu S, Leung A, Bo Y, Kozak RA, Anand SP, Warkentin C, Salambanga FDR, Cui J, Kobinger G, Kobasa D, Cote M. Virology. 2018 Jan 1;513:17-28. doi: 10.1016/j.virol.2017.09.028. Epub 2017 Oct 12. PubMed |
CRISPR/Cas9-mediated gene knockout is insensitive to target copy number but is dependent on guide RNA potency and Cas9/sgRNA threshold expression level.
Yuen G, Khan FJ, Gao S, Stommel JM, Batchelor E, Wu X, Luo J.
Nucleic Acids Res. 2017 Nov 16;45(20):12039-12053. doi: 10.1093/nar/gkx843.
PubMed
Associated Plasmids |
| TRIM29 promotes DNA virus infections by inhibiting innate immune response. Xing J, Zhang A, Zhang H, Wang J, Li XC, Zeng MS, Zhang Z. Nat Commun. 2017 Oct 16;8(1):945. doi: 10.1038/s41467-017-00101-w. PubMed |
| Regulation of NOTCH signaling by RAB7 and RAB8 requires carboxyl methylation by ICMT. Court H, Ahearn IM, Amoyel M, Bach EA, Philips MR. J Cell Biol. 2017 Dec 4;216(12):4165-4182. doi: 10.1083/jcb.201701053. Epub 2017 Oct 19. PubMed |
| Epithelial-to-Mesenchymal Transition Antagonizes Response to Targeted Therapies in Lung Cancer by Suppressing BIM. Song KA, Niederst MJ, Lochmann TL, Hata AN, Kitai H, Ham J, Floros KV, Hicks MA, Hu H, Mulvey HE, Drier Y, Heisey DAR, Hughes MT, Patel NU, Lockerman EL, Garcia A, Gillepsie S, Archibald HL, Gomez-Caraballo M, Nulton TJ, Windle BE, Piotrowska Z, Sahingur SE, Taylor SM, Dozmorov M, Sequist LV, Bernstein B, Ebi H, Engelman JA, Faber AC. Clin Cancer Res. 2018 Jan 1;24(1):197-208. doi: 10.1158/1078-0432.CCR-17-1577. Epub 2017 Oct 19. PubMed |
Virus-Mediated Genome Editing via Homology-Directed Repair in Mitotic and Postmitotic Cells in Mammalian Brain.
Nishiyama J, Mikuni T, Yasuda R.
Neuron. 2017 Oct 18. pii: S0896-6273(17)30933-9. doi: 10.1016/j.neuron.2017.10.004.
PubMed
Associated Plasmids |
The Human Knockout Gene CLYBL Connects Itaconate to Vitamin B12.
Shen H, Campanello GC, Flicker D, Grabarek Z, Hu J, Luo C, Banerjee R, Mootha VK.
Cell. 2017 Nov 2;171(4):771-782.e11. doi: 10.1016/j.cell.2017.09.051. Epub 2017 Oct 19.
PubMed
Associated Plasmids |
| Rac3 regulates breast cancer invasion and metastasis by controlling adhesion and matrix degradation. Donnelly SK, Cabrera R, Mao SPH, Christin JR, Wu B, Guo W, Bravo-Cordero JJ, Condeelis JS, Segall JE, Hodgson L. J Cell Biol. 2017 Dec 4;216(12):4331-4349. doi: 10.1083/jcb.201704048. Epub 2017 Oct 23. PubMed |
| UTX-guided neural crest function underlies craniofacial features of Kabuki syndrome. Shpargel KB, Starmer J, Wang C, Ge K, Magnuson T. Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):E9046-E9055. doi: 10.1073/pnas.1705011114. Epub 2017 Oct 9. PubMed |
| Transcription factor c-Myb inhibits breast cancer lung metastasis by suppression of tumor cell seeding. Knopfova L, Biglieri E, Volodko N, Masarik M, Hermanova M, Glaus Garzon JF, Ducka M, Kucirkova T, Soucek K, Smarda J, Benes P, Borsig L. Oncogene. 2018 Feb 22;37(8):1020-1030. doi: 10.1038/onc.2017.392. Epub 2017 Oct 30. PubMed |
| Role of lysosomal channel protein TPC2 in osteoclast differentiation and bone remodeling under normal and low-magnesium conditions. Notomi T, Kuno M, Hiyama A, Nozaki T, Ohura K, Ezura Y, Noda M. J Biol Chem. 2017 Dec 22;292(51):20998-21010. doi: 10.1074/jbc.M117.780072. Epub 2017 Oct 30. PubMed |
| Activation of CaMKIIgamma potentiates T-cell acute lymphoblastic leukemia leukemogenesis via phosphorylating FOXO3a. Jiang X, Wu Z, Lu X, Zhang X, Yu Q, Gan Y, Wu B, Xu Y, Zheng W, Zhang L, Xu F, Ma A, Gan X, Huang S, Yu X, Huang W, Xu R. Oncotarget. 2017 Aug 24;8(43):75050-75064. doi: 10.18632/oncotarget.20504. eCollection 2017 Sep 26. PubMed |
| Aberrant GATA2 epigenetic dysregulation induces a GATA2/GATA6 switch in human gastric cancer. Song SH, Jeon MS, Nam JW, Kang JK, Lee YJ, Kang JY, Kim HP, Han SW, Kang GH, Kim TY. Oncogene. 2018 Feb 22;37(8):993-1004. doi: 10.1038/onc.2017.397. Epub 2017 Nov 6. PubMed |
| Nuclear TRIM25 Specifically Targets Influenza Virus Ribonucleoproteins to Block the Onset of RNA Chain Elongation. Meyerson NR, Zhou L, Guo YR, Zhao C, Tao YJ, Krug RM, Sawyer SL. Cell Host Microbe. 2017 Nov 8;22(5):627-638.e7. doi: 10.1016/j.chom.2017.10.003. Epub 2017 Nov 5. PubMed |
| Serum squamous cell carcinoma antigen as an early indicator of response during therapy of cervical cancer. Markovina S, Wang S, Henke LE, Luke CJ, Pak SC, DeWees T, Pfeifer JD, Schwarz JK, Liu W, Chen S, Mutch D, Wang X, Powell MA, Siegel BA, Dehdashti F, Silverman GA, Grigsby PW. Br J Cancer. 2018 Jan;118(1):72-78. doi: 10.1038/bjc.2017.390. Epub 2017 Nov 7. PubMed |
| CRISPR-mediated deletion of the PECAM-1 cytoplasmic domain increases receptor lateral mobility and strengthens endothelial cell junctional integrity. Liao D, Mei H, Hu Y, Newman DK, Newman PJ. Life Sci. 2018 Jan 15;193:186-193. doi: 10.1016/j.lfs.2017.11.002. Epub 2017 Nov 6. PubMed |
| CRISPR-mediated TCR replacement generates superior anticancer transgenic T cells. Legut M, Dolton G, Mian AA, Ottmann OG, Sewell AK. Blood. 2018 Jan 18;131(3):311-322. doi: 10.1182/blood-2017-05-787598. Epub 2017 Nov 9. PubMed |
A Map of Human Mitochondrial Protein Interactions Linked to Neurodegeneration Reveals New Mechanisms of Redox Homeostasis and NF-kappaB Signaling.
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| A RasGAP, DAB2IP, regulates lipid droplet homeostasis by serving as GAP toward RAB40C. Luo X, Li C, Tan R, Xu X, Wu WKK, Satoh A, Wang T, Yu S. Oncotarget. 2017 Aug 3;8(49):85415-85427. doi: 10.18632/oncotarget.19960. eCollection 2017 Oct 17. PubMed |
| EMT programs promote basal mammary stem cell and tumor-initiating cell stemness by inducing primary ciliogenesis and Hedgehog signaling. Guen VJ, Chavarria TE, Kroger C, Ye X, Weinberg RA, Lees JA. Proc Natl Acad Sci U S A. 2017 Dec 5;114(49):E10532-E10539. doi: 10.1073/pnas.1711534114. Epub 2017 Nov 20. PubMed |
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| A non-canonical Notch complex regulates adherens junctions and vascular barrier function. Polacheck WJ, Kutys ML, Yang J, Eyckmans J, Wu Y, Vasavada H, Hirschi KK, Chen CS. Nature. 2017 Dec 14;552(7684):258-262. doi: 10.1038/nature24998. Epub 2017 Nov 13. PubMed |
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| Nicotinic Acetylcholine Receptor Subtype Alpha-9 Mediates Triple-Negative Breast Cancers Based on a Spontaneous Pulmonary Metastasis Mouse Model. Huang LC, Lin CL, Qiu JZ, Lin CY, Hsu KW, Tam KW, Lee JY, Yang JM, Lee CH. Front Cell Neurosci. 2017 Nov 3;11:336. doi: 10.3389/fncel.2017.00336. eCollection 2017. PubMed |
| ETS1 induction by the microenvironment promotes ovarian cancer metastasis through focal adhesion kinase. Tomar S, Plotnik JP, Haley J, Scantland J, Dasari S, Sheikh Z, Emerson R, Lenz D, Hollenhorst PC, Mitra AK. Cancer Lett. 2018 Feb 1;414:190-204. doi: 10.1016/j.canlet.2017.11.012. Epub 2017 Nov 22. PubMed |
| Nutlin sensitizes lung carcinoma cells to interferon-alpha treatment in MDM2-dependent but p53-independent manner. Shuvalov O, Kizenko A, Shakirova A, Fedorova O, Petukhov A, Aksenov N, Vasileva E, Daks A, Barlev N. Biochem Biophys Res Commun. 2018 Jan 1;495(1):1233-1239. doi: 10.1016/j.bbrc.2017.11.118. Epub 2017 Nov 23. PubMed |
| Bicaudal D2 facilitates the cytoplasmic trafficking and nuclear import of HIV-1 genomes during infection. Dharan A, Opp S, Abdel-Rahim O, Keceli SK, Imam S, Diaz-Griffero F, Campbell EM. Proc Natl Acad Sci U S A. 2017 Dec 12;114(50):E10707-E10716. doi: 10.1073/pnas.1712033114. Epub 2017 Nov 27. PubMed |
| The IFN Response in Bats Displays Distinctive IFN-Stimulated Gene Expression Kinetics with Atypical RNASEL Induction. De La Cruz-Rivera PC, Kanchwala M, Liang H, Kumar A, Wang LF, Xing C, Schoggins JW. J Immunol. 2018 Jan 1;200(1):209-217. doi: 10.4049/jimmunol.1701214. Epub 2017 Nov 27. PubMed |
| Inactivation of DNA repair triggers neoantigen generation and impairs tumour growth. Germano G, Lamba S, Rospo G, Barault L, Magri A, Maione F, Russo M, Crisafulli G, Bartolini A, Lerda G, Siravegna G, Mussolin B, Frapolli R, Montone M, Morano F, de Braud F, Amirouchene-Angelozzi N, Marsoni S, D'Incalci M, Orlandi A, Giraudo E, Sartore-Bianchi A, Siena S, Pietrantonio F, Di Nicolantonio F, Bardelli A. Nature. 2017 Dec 7;552(7683):116-120. doi: 10.1038/nature24673. Epub 2017 Nov 29. PubMed |
| Identification of a Raloxifene Analog That Promotes AhR-Mediated Apoptosis in Cancer Cells. Jang HS, Pearce M, O'Donnell EF, Nguyen BD, Truong L, Mueller MJ, Bisson WH, Kerkvliet NI, Tanguay RL, Kolluri SK. Biology (Basel). 2017 Dec 1;6(4). pii: biology6040041. doi: 10.3390/biology6040041. PubMed |
| The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages. Evavold CL, Ruan J, Tan Y, Xia S, Wu H, Kagan JC. Immunity. 2018 Jan 16;48(1):35-44.e6. doi: 10.1016/j.immuni.2017.11.013. Epub 2017 Nov 28. PubMed |
| Single-Cell Transcriptomic Analysis of Primary and Metastatic Tumor Ecosystems in Head and Neck Cancer. Puram SV, Tirosh I, Parikh AS, Patel AP, Yizhak K, Gillespie S, Rodman C, Luo CL, Mroz EA, Emerick KS, Deschler DG, Varvares MA, Mylvaganam R, Rozenblatt-Rosen O, Rocco JW, Faquin WC, Lin DT, Regev A, Bernstein BE. Cell. 2017 Dec 14;171(7):1611-1624.e24. doi: 10.1016/j.cell.2017.10.044. Epub 2017 Nov 30. PubMed |
| LDB2 inhibits proliferation and migration in liver cancer cells by abrogating HEY1 expression. Yu H, Jia R, Zhao L, Song S, Gu J, Zhang H. Oncotarget. 2017 Oct 10;8(55):94440-94449. doi: 10.18632/oncotarget.21772. eCollection 2017 Nov 7. PubMed |
| Syndecan-1 promotes Wnt/beta-catenin signaling in multiple myeloma by presenting Wnts and R-spondins. Ren Z, van Andel H, de Lau W, Hartholt RB, Maurice MM, Clevers H, Kersten MJ, Spaargaren M, Pals ST. Blood. 2018 Mar 1;131(9):982-994. doi: 10.1182/blood-2017-07-797050. Epub 2017 Dec 6. PubMed |
| Role of Dopamine Receptors in the Anticancer Activity of ONC201. Kline CLB, Ralff MD, Lulla AR, Wagner JM, Abbosh PH, Dicker DT, Allen JE, El-Deiry WS. Neoplasia. 2018 Jan;20(1):80-91. doi: 10.1016/j.neo.2017.10.002. Epub 2017 Dec 5. PubMed |
| Tumor suppressor p53 links ceramide metabolism to DNA damage response through alkaline ceramidase 2. Xu R, Garcia-Barros M, Wen S, Li F, Lin CL, Hannun YA, Obeid LM, Mao C. Cell Death Differ. 2018 May;25(5):841-856. doi: 10.1038/s41418-017-0018-y. Epub 2017 Dec 11. PubMed |
| Therapeutic relevance of the PP2A-B55 inhibitory kinase MASTL/Greatwall in breast cancer. Alvarez-Fernandez M, Sanz-Flores M, Sanz-Castillo B, Salazar-Roa M, Partida D, Zapatero-Solana E, Ali HR, Manchado E, Lowe S, VanArsdale T, Shields D, Caldas C, Quintela-Fandino M, Malumbres M. Cell Death Differ. 2017 Dec 11. pii: 10.1038/s41418-017-0024-0. doi: 10.1038/s41418-017-0024-0. PubMed |
| Autophagy induced during apoptosis degrades mitochondria and inhibits type I interferon secretion. Lindqvist LM, Frank D, McArthur K, Dite TA, Lazarou M, Oakhill JS, Kile BT, Vaux DL. Cell Death Differ. 2018 Mar;25(4):784-796. doi: 10.1038/s41418-017-0017-z. Epub 2017 Dec 11. PubMed |
| Probing the requirement for CD38 in retinoic acid-induced HL-60 cell differentiation with a small molecule dimerizer and genetic knockout. MacDonald RJ, Shrimp JH, Jiang H, Zhang L, Lin H, Yen A. Sci Rep. 2017 Dec 12;7(1):17406. doi: 10.1038/s41598-017-17720-4. PubMed |
| Endothelial-derived interleukin-6 induces cancer stem cell motility by generating a chemotactic gradient towards blood vessels. Kim HS, Chen YC, Nor F, Warner KA, Andrews A, Wagner VP, Zhang Z, Zhang Z, Martins MD, Pearson AT, Yoon E, Nor JE. Oncotarget. 2017 Nov 1;8(59):100339-100352. doi: 10.18632/oncotarget.22225. eCollection 2017 Nov 21. PubMed |
| In Vivo Knockout of the Vegfa Gene by Lentiviral Delivery of CRISPR/Cas9 in Mouse Retinal Pigment Epithelium Cells. Holmgaard A, Askou AL, Benckendorff JNE, Thomsen EA, Cai Y, Bek T, Mikkelsen JG, Corydon TJ. Mol Ther Nucleic Acids. 2017 Dec 15;9:89-99. doi: 10.1016/j.omtn.2017.08.016. Epub 2017 Sep 21. PubMed |
| Cell-penetrating peptides derived from Clostridium difficile TcdB2 and a related large clostridial toxin. Larabee JL, Hauck GD, Ballard JD. J Biol Chem. 2018 Feb 2;293(5):1810-1819. doi: 10.1074/jbc.M117.815373. Epub 2017 Dec 15. PubMed |
| Coronaviruses and arteriviruses display striking differences in their cyclophilin A-dependence during replication in cell culture. de Wilde AH, Zevenhoven-Dobbe JC, Beugeling C, Chatterji U, de Jong D, Gallay P, Szuhai K, Posthuma CC, Snijder EJ. Virology. 2018 Apr;517:148-156. doi: 10.1016/j.virol.2017.11.022. Epub 2017 Dec 15. PubMed |
R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m(6)A/MYC/CEBPA Signaling.
Su R, Dong L, Li C, Nachtergaele S, Wunderlich M, Qing Y, Deng X, Wang Y, Weng X, Hu C, Yu M, Skibbe J, Dai Q, Zou D, Wu T, Yu K, Weng H, Huang H, Ferchen K, Qin X, Zhang B, Qi J, Sasaki AT, Plas DR, Bradner JE, Wei M, Marcucci G, Jiang X, Mulloy JC, Jin J, He C, Chen J.
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| The PLAG1-GDH1 Axis Promotes Anoikis Resistance and Tumor Metastasis through CamKK2-AMPK Signaling in LKB1-Deficient Lung Cancer. Jin L, Chun J, Pan C, Kumar A, Zhang G, Ha Y, Li D, Alesi GN, Kang Y, Zhou L, Yu WM, Magliocca KR, Khuri FR, Qu CK, Metallo C, Owonikoko TK, Kang S. Mol Cell. 2018 Jan 4;69(1):87-99.e7. doi: 10.1016/j.molcel.2017.11.025. Epub 2017 Dec 14. PubMed |
| FOXC1-induced non-canonical WNT5A-MMP7 signaling regulates invasiveness in triple-negative breast cancer. Han B, Zhou B, Qu Y, Gao B, Xu Y, Chung S, Tanaka H, Yang W, Giuliano AE, Cui X. Oncogene. 2018 Mar;37(10):1399-1408. doi: 10.1038/s41388-017-0021-2. Epub 2017 Dec 18. PubMed |
| Histone deacetylase 6 (HDAC6) deacetylates extracellular signal-regulated kinase 1 (ERK1) and thereby stimulates ERK1 activity. Wu JY, Xiang S, Zhang M, Fang B, Huang H, Kwon OK, Zhao Y, Yang Z, Bai W, Bepler G, Zhang XM. J Biol Chem. 2018 Feb 9;293(6):1976-1993. doi: 10.1074/jbc.M117.795955. Epub 2017 Dec 19. PubMed |
| Cucurbitacin B and SCH772984 exhibit synergistic anti-pancreatic cancer activities by suppressing EGFR, PI3K/Akt/mTOR, STAT3 and ERK signaling. Zhou J, Zhao T, Ma L, Liang M, Guo YJ, Zhao LM. Oncotarget. 2017 Oct 9;8(61):103167-103181. doi: 10.18632/oncotarget.21704. eCollection 2017 Nov 28. PubMed |
| Emerging Alphaviruses Are Sensitive to Cellular States Induced by a Novel Small-Molecule Agonist of the STING Pathway. Gall B, Pryke K, Abraham J, Mizuno N, Botto S, Sali TM, Broeckel R, Haese N, Nilsen A, Placzek A, Morrison T, Heise M, Streblow D, DeFilippis V. J Virol. 2018 Feb 26;92(6). pii: JVI.01913-17. doi: 10.1128/JVI.01913-17. Print 2018 Mar 15. PubMed |
| A Protocol for the Production of Integrase-deficient Lentiviral Vectors for CRISPR/Cas9-mediated Gene Knockout in Dividing Cells. Vijayraghavan S, Kantor B. J Vis Exp. 2017 Dec 12;(130). doi: 10.3791/56915. PubMed |
| The role of host DNA ligases in hepadnavirus covalently closed circular DNA formation. Long Q, Yan R, Hu J, Cai D, Mitra B, Kim ES, Marchetti A, Zhang H, Wang S, Liu Y, Huang A, Guo H. PLoS Pathog. 2017 Dec 29;13(12):e1006784. doi: 10.1371/journal.ppat.1006784. eCollection 2017 Dec. PubMed |
| The p38 Mitogen-Activated Protein Kinase Critically Regulates Human Keratinocyte Inflammasome Activation. Fenini G, Grossi S, Gehrke S, Beer HD, Satoh TK, Contassot E, French LE. J Invest Dermatol. 2018 Jun;138(6):1380-1390. doi: 10.1016/j.jid.2017.10.037. Epub 2017 Dec 26. PubMed |
| CRISPR Screens Uncover Genes that Regulate Target Cell Sensitivity to the Morphogen Sonic Hedgehog. Pusapati GV, Kong JH, Patel BB, Krishnan A, Sagner A, Kinnebrew M, Briscoe J, Aravind L, Rohatgi R. Dev Cell. 2018 Jan 8;44(1):113-129.e8. doi: 10.1016/j.devcel.2017.12.003. Epub 2017 Dec 28. PubMed |
| Scarless Genome Editing of Human Pluripotent Stem Cells via Transient Puromycin Selection. Steyer B, Bu Q, Cory E, Jiang K, Duong S, Sinha D, Steltzer S, Gamm D, Chang Q, Saha K. Stem Cell Reports. 2018 Feb 13;10(2):642-654. doi: 10.1016/j.stemcr.2017.12.004. Epub 2018 Jan 4. PubMed |
| DEPDC5 deficiency contributes to resistance to leucine starvation via p62 accumulation in hepatocellular carcinoma. Mizuno Y, Shimada S, Akiyama Y, Watanabe S, Aida T, Ogawa K, Ono H, Mitsunori Y, Ban D, Kudo A, Arii S, Yamaoka S, Tanabe M, Tanaka S. Sci Rep. 2018 Jan 8;8(1):106. doi: 10.1038/s41598-017-18323-9. PubMed |
| Combined shRNA over CRISPR/cas9 as a methodology to detect off-target effects and a potential compensatory mechanism. Peretz L, Besser E, Hajbi R, Casden N, Ziv D, Kronenberg N, Gigi LB, Sweetat S, Khawaled S, Aqeilan R, Behar O. Sci Rep. 2018 Jan 8;8(1):93. doi: 10.1038/s41598-017-18551-z. PubMed |
| Force Generation via beta-Cardiac Myosin, Titin, and alpha-Actinin Drives Cardiac Sarcomere Assembly from Cell-Matrix Adhesions. Chopra A, Kutys ML, Zhang K, Polacheck WJ, Sheng CC, Luu RJ, Eyckmans J, Hinson JT, Seidman JG, Seidman CE, Chen CS. Dev Cell. 2018 Jan 8;44(1):87-96.e5. doi: 10.1016/j.devcel.2017.12.012. Epub 2018 Jan 8. PubMed |
| Modest Decreases in Endogenous All-trans-Retinoic Acid Produced by a Mouse Rdh10 Heterozygote Provoke Major Abnormalities in Adipogenesis and Lipid Metabolism. Yang D, Vuckovic MG, Smullin CP, Kim M, Lo CP, Devericks E, Yoo HS, Tintcheva M, Deng Y, Napoli JL. Diabetes. 2018 Apr;67(4):662-673. doi: 10.2337/db17-0946. Epub 2018 Jan 10. PubMed |
| An intrinsic lipid-binding interface controls sphingosine kinase 1 function. Pulkoski-Gross MJ, Jenkins ML, Truman JP, Salama MF, Clarke CJ, Burke JE, Hannun YA, Obeid LM. J Lipid Res. 2018 Mar;59(3):462-474. doi: 10.1194/jlr.M081307. Epub 2018 Jan 11. PubMed |
| ARID5B as a critical downstream target of the TAL1 complex that activates the oncogenic transcriptional program and promotes T-cell leukemogenesis. Leong WZ, Tan SH, Ngoc PCT, Amanda S, Yam AWY, Liau WS, Gong Z, Lawton LN, Tenen DG, Sanda T. Genes Dev. 2017 Dec 1;31(23-24):2343-2360. doi: 10.1101/gad.302646.117. Epub 2018 Jan 11. PubMed |
| Foxo-dependent Par-4 Upregulation Prevents Long-term Survival of Residual Cells Following PI3K-Akt Inhibition. Damrauer JS, Phelps SN, Amuchastegui K, Lupo R, Mabe NW, Walens A, Kroger BR, Alvarez JV. Mol Cancer Res. 2018 Apr;16(4):599-609. doi: 10.1158/1541-7786.MCR-17-0492. Epub 2018 Jan 12. PubMed |
| BRCA1 through Its E3 Ligase Activity Regulates the Transcription Factor Oct1 and Carbohydrate Metabolism. Vazquez-Arreguin K, Maddox J, Kang J, Park D, Cano RR, Factor RE, Ludwig T, Tantin D. Mol Cancer Res. 2018 Mar;16(3):439-452. doi: 10.1158/1541-7786.MCR-17-0364. Epub 2018 Jan 12. PubMed |
| As Extracellular Glutamine Levels Decline, Asparagine Becomes an Essential Amino Acid. Pavlova NN, Hui S, Ghergurovich JM, Fan J, Intlekofer AM, White RM, Rabinowitz JD, Thompson CB, Zhang J. Cell Metab. 2018 Feb 6;27(2):428-438.e5. doi: 10.1016/j.cmet.2017.12.006. Epub 2018 Jan 11. PubMed |
| PD-L1 on host cells is essential for PD-L1 blockade-mediated tumor regression. Tang H, Liang Y, Anders RA, Taube JM, Qiu X, Mulgaonkar A, Liu X, Harrington SM, Guo J, Xin Y, Xiong Y, Nham K, Silvers W, Hao G, Sun X, Chen M, Hannan R, Qiao J, Dong H, Peng H, Fu YX. J Clin Invest. 2018 Feb 1;128(2):580-588. doi: 10.1172/JCI96061. Epub 2018 Jan 16. PubMed |
| Histone Variant MacroH2A1 Plays an Isoform-Specific Role in Suppressing Epithelial-Mesenchymal Transition. Hodge DQ, Cui J, Gamble MJ, Guo W. Sci Rep. 2018 Jan 16;8(1):841. doi: 10.1038/s41598-018-19364-4. PubMed |
| CYR61/CCN1 Regulates Sclerostin Levels and Bone Maintenance. Zhao G, Huang BL, Rigueur D, Wang W, Bhoot C, Charles KR, Baek J, Mohan S, Jiang J, Lyons KM. J Bone Miner Res. 2018 Jun;33(6):1076-1089. doi: 10.1002/jbmr.3394. Epub 2018 Mar 5. PubMed |
| A Distinct Class of Genome Rearrangements Driven by Heterologous Recombination. Leon-Ortiz AM, Panier S, Sarek G, Vannier JB, Patel H, Campbell PJ, Boulton SJ. Mol Cell. 2018 Jan 18;69(2):292-305.e6. doi: 10.1016/j.molcel.2017.12.014. PubMed |
| Interferon regulatory factor 8 regulates caspase-1 expression to facilitate Epstein-Barr virus reactivation in response to B cell receptor stimulation and chemical induction. Lv DW, Zhang K, Li R. PLoS Pathog. 2018 Jan 22;14(1):e1006868. doi: 10.1371/journal.ppat.1006868. eCollection 2018 Jan. PubMed |
| Large-scale image-based profiling of single-cell phenotypes in arrayed CRISPR-Cas9 gene perturbation screens. de Groot R, Luthi J, Lindsay H, Holtackers R, Pelkmans L. Mol Syst Biol. 2018 Jan 23;14(1):e8064. doi: 10.15252/msb.20178064. PubMed |
| IKKbeta is a beta-catenin kinase that regulates mesenchymal stem cell differentiation. Sui Y, Liu Z, Park SH, Thatcher SE, Zhu B, Fernandez JP, Molina H, Kern PA, Zhou C. JCI Insight. 2018 Jan 25;3(2). pii: 96660. doi: 10.1172/jci.insight.96660. eCollection 2018 Jan 25. PubMed |
| A positive feedback loop between IL-1beta, LPS and NEU1 may promote atherosclerosis by enhancing a pro-inflammatory state in monocytes and macrophages. Sieve I, Ricke-Hoch M, Kasten M, Battmer K, Stapel B, Falk CS, Leisegang MS, Haverich A, Scherr M, Hilfiker-Kleiner D. Vascul Pharmacol. 2018 Apr;103-105:16-28. doi: 10.1016/j.vph.2018.01.005. Epub 2018 Jan 31. PubMed |
| Editing of the human TRIM5 gene to introduce mutations with the potential to inhibit HIV-1. Dufour C, Claudel A, Joubarne N, Merindol N, Maisonnet T, Masroori N, Plourde MB, Berthoux L. PLoS One. 2018 Jan 26;13(1):e0191709. doi: 10.1371/journal.pone.0191709. eCollection 2018. PubMed |
Glioma tumor suppressor candidate region gene 1 (GLTSCR1) and its paralog GLTSCR1-like form SWI/SNF chromatin remodeling subcomplexes.
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| The non-classical nuclear import carrier Transportin 1 modulates circadian rhythms through its effect on PER1 nuclear localization. Korge S, Maier B, Bruning F, Ehrhardt L, Korte T, Mann M, Herrmann A, Robles MS, Kramer A. PLoS Genet. 2018 Jan 29;14(1):e1007189. doi: 10.1371/journal.pgen.1007189. eCollection 2018 Jan. PubMed |
| AXL promotes Zika virus infection in astrocytes by antagonizing type I interferon signalling. Chen J, Yang YF, Yang Y, Zou P, Chen J, He Y, Shui SL, Cui YR, Bai R, Liang YJ, Hu Y, Jiang B, Lu L, Zhang X, Liu J, Xu J. Nat Microbiol. 2018 Mar;3(3):302-309. doi: 10.1038/s41564-017-0092-4. Epub 2018 Jan 29. PubMed |
| Discovery of Potent and Selective MRCK Inhibitors with Therapeutic Effect on Skin Cancer. Unbekandt M, Belshaw S, Bower J, Clarke M, Cordes J, Crighton D, Croft DR, Drysdale MJ, Garnett MJ, Gill K, Gray C, Greenhalgh DA, Hall JAM, Konczal J, Lilla S, McArthur D, McConnell P, McDonald L, McGarry L, McKinnon H, McMenemy C, Mezna M, Morrice NA, Munro J, Naylor G, Rath N, Schuttelkopf AW, Sime M, Olson MF. Cancer Res. 2018 Apr 15;78(8):2096-2114. doi: 10.1158/0008-5472.CAN-17-2870. Epub 2018 Jan 30. PubMed |
| Mucolipin-2 Cation Channel Increases Trafficking Efficiency of Endocytosed Viruses. Rinkenberger N, Schoggins JW. MBio. 2018 Jan 30;9(1). pii: mBio.02314-17. doi: 10.1128/mBio.02314-17. PubMed |
| Altering lipid droplet homeostasis affects Coxiella burnetii intracellular growth. Mulye M, Zapata B, Gilk SD. PLoS One. 2018 Feb 1;13(2):e0192215. doi: 10.1371/journal.pone.0192215. eCollection 2018. PubMed |
| Desensitized chimeric antigen receptor T cells selectively recognize target cells with enhanced antigen expression. Han C, Sim SJ, Kim SH, Singh R, Hwang S, Kim YI, Park SH, Kim KH, Lee DG, Oh HS, Lee S, Kim YH, Choi BK, Kwon BS. Nat Commun. 2018 Feb 1;9(1):468. doi: 10.1038/s41467-018-02912-x. PubMed |
| TRPC3 is required for the survival, pluripotency and neural differentiation of mouse embryonic stem cells (mESCs). Hao HB, Webb SE, Yue J, Moreau M, Leclerc C, Miller AL. Sci China Life Sci. 2018 Mar;61(3):253-265. doi: 10.1007/s11427-017-9222-9. Epub 2018 Jan 31. PubMed |
| Integrin CD11b negatively regulates Mincle-induced signaling via the Lyn-SIRPalpha-SHP1 complex. Zhang Q, Lee WB, Kang JS, Kim LK, Kim YJ. Exp Mol Med. 2018 Feb 5;50(2):e439. doi: 10.1038/emm.2017.256. PubMed |
| CRISPR interference-based specific and efficient gene inactivation in the brain. Zheng Y, Shen W, Zhang J, Yang B, Liu YN, Qi H, Yu X, Lu SY, Chen Y, Xu YZ, Li Y, Gage FH, Mi S, Yao J. Nat Neurosci. 2018 Mar;21(3):447-454. doi: 10.1038/s41593-018-0077-5. Epub 2018 Feb 5. PubMed |
| Long noncoding RNA PANDAR blocks CDKN1A gene transcription by competitive interaction with p53 protein in gastric cancer. Liu J, Ben Q, Lu E, He X, Yang X, Ma J, Zhang W, Wang Z, Liu T, Zhang J, Wang H. Cell Death Dis. 2018 Feb 7;9(2):168. doi: 10.1038/s41419-017-0246-6. PubMed |
| Primary Airway Epithelial Cell Gene Editing Using CRISPR-Cas9. Everman JL, Rios C, Seibold MA. Methods Mol Biol. 2018;1706:267-292. doi: 10.1007/978-1-4939-7471-9_15. PubMed |
| Secreted AGR2 promotes invasion of colorectal cancer cells via Wnt11-mediated non-canonical Wnt signaling. Tian S, Hu J, Tao K, Wang J, Chu Y, Li J, Liu Z, Ding X, Xu L, Li Q, Cai M, Gao J, Shuai X, Wang G, Wang L, Wang Z. Exp Cell Res. 2018 Mar 15;364(2):198-207. doi: 10.1016/j.yexcr.2018.02.004. Epub 2018 Feb 7. PubMed |
| Differential Delivery of Genomic Double-Stranded RNA Causes Reovirus Strain-Specific Differences in Interferon Regulatory Factor 3 Activation. Stuart JD, Holm GH, Boehme KW. J Virol. 2018 Apr 13;92(9). pii: JVI.01947-17. doi: 10.1128/JVI.01947-17. Print 2018 May 1. PubMed |
| MYL6B, a myosin light chain, promotes MDM2-mediated p53 degradation and drives HCC development. Xie X, Wang X, Liao W, Fei R, Wu N, Cong X, Chen Q, Wei L, Wang Y, Chen H. J Exp Clin Cancer Res. 2018 Feb 13;37(1):28. doi: 10.1186/s13046-018-0693-7. PubMed |
| A Human Genome-Wide RNAi Screen Reveals Diverse Modulators that Mediate IRE1alpha-XBP1 Activation. Yang Z, Zhang J, Jiang D, Khatri P, Solow-Cordero DE, Toesca DAS, Koumenis C, Denko NC, Giaccia AJ, Le QT, Koong AC. Mol Cancer Res. 2018 May;16(5):745-753. doi: 10.1158/1541-7786.MCR-17-0307. Epub 2018 Feb 9. PubMed |
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| Dynamic network biomarker indicates pulmonary metastasis at the tipping point of hepatocellular carcinoma. Yang B, Li M, Tang W, Liu W, Zhang S, Chen L, Xia J. Nat Commun. 2018 Feb 14;9(1):678. doi: 10.1038/s41467-018-03024-2. PubMed |
| A paralogous pair of mammalian host restriction factors form a critical host barrier against poxvirus infection. Meng X, Zhang F, Yan B, Si C, Honda H, Nagamachi A, Sun LZ, Xiang Y. PLoS Pathog. 2018 Feb 15;14(2):e1006884. doi: 10.1371/journal.ppat.1006884. eCollection 2018 Feb. PubMed |
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| Inhibition of autophagy sensitizes cancer cells to Photofrin-based photodynamic therapy. Domagala A, Stachura J, Gabrysiak M, Muchowicz A, Zagozdzon R, Golab J, Firczuk M. BMC Cancer. 2018 Feb 20;18(1):210. doi: 10.1186/s12885-018-4126-y. PubMed |
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| Knockdown of Human AMPK Using the CRISPR/Cas9 Genome-Editing System. Grenier A, Sujobert P, Olivier S, Guermouche H, Mondesir J, Kosmider O, Viollet B, Tamburini J. Methods Mol Biol. 2018;1732:171-194. doi: 10.1007/978-1-4939-7598-3_11. PubMed |
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| Novel RNA-Affinity Proteogenomics Dissects Tumor Heterogeneity for Revealing Personalized Markers in Precision Prognosis of Cancer. Wang L, Wrobel JA, Xie L, Li D, Zurlo G, Shen H, Yang P, Wang Z, Peng Y, Gunawardena HP, Zhang Q, Chen X. Cell Chem Biol. 2018 May 17;25(5):619-633.e5. doi: 10.1016/j.chembiol.2018.01.016. Epub 2018 Mar 1. PubMed |
| Robust DNA repair in PAXX-deficient mammalian cells. Dewan A, Xing M, Lundbaek MB, Gago-Fuentes R, Beck C, Aas PA, Liabakk NB, Saeterstad S, Chau KTP, Kavli BM, Oksenych V. FEBS Open Bio. 2018 Feb 7;8(3):442-448. doi: 10.1002/2211-5463.12380. eCollection 2018 Mar. PubMed |
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| Porcine MKRN1 Modulates the Replication and Pathogenesis of Porcine Circovirus Type 2 by Inducing Capsid Protein Ubiquitination and Degradation. Wang T, Du Q, Wu X, Niu Y, Guan L, Wang Z, Zhao X, Liu SL, Tong D, Huang Y. J Virol. 2018 May 14;92(11). pii: JVI.00100-18. doi: 10.1128/JVI.00100-18. Print 2018 Jun 1. PubMed |
| Exploiting an Asp-Glu "switch" in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia. Wagner FF, Benajiba L, Campbell AJ, Weiwer M, Sacher JR, Gale JP, Ross L, Puissant A, Alexe G, Conway A, Back M, Pikman Y, Galinsky I, DeAngelo DJ, Stone RM, Kaya T, Shi X, Robers MB, Machleidt T, Wilkinson J, Hermine O, Kung A, Stein AJ, Lakshminarasimhan D, Hemann MT, Scolnick E, Zhang YL, Pan JQ, Stegmaier K, Holson EB. Sci Transl Med. 2018 Mar 7;10(431):eaam8460. doi: 10.1126/scitranslmed.aam8460. PubMed |
| The convergent roles of NF-kappaB and ER stress in sunitinib-mediated expression of pro-tumorigenic cytokines and refractory phenotype in renal cell carcinoma. Makhov P, Naito S, Haifler M, Kutikov A, Boumber Y, Uzzo RG, Kolenko VM. Cell Death Dis. 2018 Mar 7;9(3):374. doi: 10.1038/s41419-018-0388-1. PubMed |
| Caspase-3 regulates the migration, invasion and metastasis of colon cancer cells. Zhou M, Liu X, Li Z, Huang Q, Li F, Li CY. Int J Cancer. 2018 Aug 15;143(4):921-930. doi: 10.1002/ijc.31374. Epub 2018 Mar 30. PubMed |
| Human IFIT3 Modulates IFIT1 RNA Binding Specificity and Protein Stability. Johnson B, VanBlargan LA, Xu W, White JP, Shan C, Shi PY, Zhang R, Adhikari J, Gross ML, Leung DW, Diamond MS, Amarasinghe GK. Immunity. 2018 Mar 20;48(3):487-499.e5. doi: 10.1016/j.immuni.2018.01.014. Epub 2018 Mar 8. PubMed |
| Insulin resistance causes inflammation in adipose tissue. Shimobayashi M, Albert V, Woelnerhanssen B, Frei IC, Weissenberger D, Meyer-Gerspach AC, Clement N, Moes S, Colombi M, Meier JA, Swierczynska MM, Jeno P, Beglinger C, Peterli R, Hall MN. J Clin Invest. 2018 Apr 2;128(4):1538-1550. doi: 10.1172/JCI96139. Epub 2018 Mar 12. PubMed |
NuRD and CAF-1-mediated silencing of the D4Z4 array is modulated by DUX4-induced MBD3L proteins.
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Elife. 2018 Mar 13;7. pii: 31023. doi: 10.7554/eLife.31023.
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| Intraflagellar transport is deeply integrated in hedgehog signaling. Eguether T, Cordelieres FP, Pazour GJ. Mol Biol Cell. 2018 May 15;29(10):1178-1189. doi: 10.1091/mbc.E17-10-0600. Epub 2018 Mar 22. PubMed |
| Reshaping of the Dendritic Cell Chromatin Landscape and Interferon Pathways during HIV Infection. Johnson JS, Lucas SY, Amon LM, Skelton S, Nazitto R, Carbonetti S, Sather DN, Littman DR, Aderem A. Cell Host Microbe. 2018 Mar 14;23(3):366-381.e9. doi: 10.1016/j.chom.2018.01.012. PubMed |
| PI3K Positively Regulates YAP and TAZ in Mammary Tumorigenesis Through Multiple Signaling Pathways. Zhao Y, Montminy T, Azad T, Lightbody E, Hao Y, SenGupta S, Asselin E, Nicol C, Yang X. Mol Cancer Res. 2018 Jun;16(6):1046-1058. doi: 10.1158/1541-7786.MCR-17-0593. Epub 2018 Mar 15. PubMed |
Coordinated Activity of Y Family TLS Polymerases and EXO1 Protects Non-S Phase Cells from UV-Induced Cytotoxic Lesions.
Sertic S, Mollica A, Campus I, Roma S, Tumini E, Aguilera A, Muzi-Falconi M.
Mol Cell. 2018 Apr 5;70(1):34-47.e4. doi: 10.1016/j.molcel.2018.02.017. Epub 2018 Mar 15.
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Thyroid transcription factor 1 enhances cellular statin sensitivity via perturbing cholesterol metabolism.
Lai SC, Phelps CA, Short AM, Dutta SM, Mu D.
Oncogene. 2018 Mar 19. pii: 10.1038/s41388-018-0174-7. doi: 10.1038/s41388-018-0174-7.
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A CRISPR screen for factors regulating SAMHD1 degradation identifies IFITMs as potent inhibitors of lentiviral particle delivery.
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Retrovirology. 2018 Mar 20;15(1):26. doi: 10.1186/s12977-018-0409-2.
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| Detection of aryl hydrocarbon receptor agonists in human samples. Rothhammer V, Borucki DM, Kenison JE, Hewson P, Wang Z, Bakshi R, Sherr DH, Quintana FJ. Sci Rep. 2018 Mar 21;8(1):4970. doi: 10.1038/s41598-018-23323-4. PubMed |
| Notch and Aryl Hydrocarbon Receptor Signaling Impact Definitive Hematopoiesis from Human Pluripotent Stem Cells. Leung A, Zulick E, Skvir N, Vanuytsel K, Morrison TA, Naing ZH, Wang Z, Dai Y, Chui DHK, Steinberg MH, Sherr DH, Murphy GJ. Stem Cells. 2018 Jul;36(7):1004-1019. doi: 10.1002/stem.2822. Epub 2018 Apr 1. PubMed |
| Dnmt3a in the dorsal dentate gyrus is a key regulator of fear renewal. Gong Z, Zhou Q. Sci Rep. 2018 Mar 23;8(1):5093. doi: 10.1038/s41598-018-23533-w. PubMed |
| Profound Tissue Specificity in Proliferation Control Underlies Cancer Drivers and Aneuploidy Patterns. Sack LM, Davoli T, Li MZ, Li Y, Xu Q, Naxerova K, Wooten EC, Bernardi RJ, Martin TD, Chen T, Leng Y, Liang AC, Scorsone KA, Westbrook TF, Wong KK, Elledge SJ. Cell. 2018 Apr 5;173(2):499-514.e23. doi: 10.1016/j.cell.2018.02.037. Epub 2018 Mar 22. PubMed |
| L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage. Nowsheen S, Aziz K, Aziz A, Deng M, Qin B, Luo K, Jeganathan KB, Zhang H, Liu T, Yu J, Deng Y, Yuan J, Ding W, van Deursen JM, Lou Z. Nat Cell Biol. 2018 Apr;20(4):455-464. doi: 10.1038/s41556-018-0071-x. Epub 2018 Mar 26. PubMed |
| Use of Organoids to Characterize Signaling Pathways in Cancer Initiation. Oatway C, Hirsch CL, Gregorieff A. Methods Mol Biol. 2018;1765:315-331. doi: 10.1007/978-1-4939-7765-9_21. PubMed |
| A multiplatform approach identifies miR-152-3p as a common epigenetically regulated onco-suppressor in prostate cancer targeting TMEM97. Ramalho-Carvalho J, Goncalves CS, Graca I, Bidarra D, Pereira-Silva E, Salta S, Godinho MI, Gomez A, Esteller M, Costa BM, Henrique R, Jeronimo C. Clin Epigenetics. 2018 Mar 27;10:40. doi: 10.1186/s13148-018-0475-2. eCollection 2018. PubMed |
| Impact of Nrf2 on tumour growth and drug sensitivity in oncogenic K-ras-transformed cells in vitro and in vivo. Shao J, Glorieux C, Liao J, Chen P, Lu W, Liang Z, Wen S, Hu Y, Huang P. Free Radic Res. 2018 Jun;52(6):661-671. doi: 10.1080/10715762.2018.1462494. Epub 2018 May 3. PubMed |
| Genome scale screening identification of SaCas9/gRNAs for targeting HIV-1 provirus and suppression of HIV-1 infection. Wang Q, Liu S, Liu Z, Ke Z, Li C, Yu X, Chen S, Guo D. Virus Res. 2018 May 2;250:21-30. doi: 10.1016/j.virusres.2018.04.002. Epub 2018 Apr 3. PubMed |
| Pseudouridylation of tRNA-Derived Fragments Steers Translational Control in Stem Cells. Guzzi N, Ciesla M, Ngoc PCT, Lang S, Arora S, Dimitriou M, Pimkova K, Sommarin MNE, Munita R, Lubas M, Lim Y, Okuyama K, Soneji S, Karlsson G, Hansson J, Jonsson G, Lund AH, Sigvardsson M, Hellstrom-Lindberg E, Hsieh AC, Bellodi C. Cell. 2018 May 17;173(5):1204-1216.e26. doi: 10.1016/j.cell.2018.03.008. Epub 2018 Apr 5. PubMed |
| A novel neuregulin - jagged1 paracrine loop in breast cancer transendothelial migration. Cabrera RM, Mao SPH, Surve CR, Condeelis JS, Segall JE. Breast Cancer Res. 2018 Apr 10;20(1):24. doi: 10.1186/s13058-018-0960-8. PubMed |
| Single HIV-1 Imaging Reveals Progression of Infection through CA-Dependent Steps of Docking at the Nuclear Pore, Uncoating, and Nuclear Transport. Francis AC, Melikyan GB. Cell Host Microbe. 2018 Apr 11;23(4):536-548.e6. doi: 10.1016/j.chom.2018.03.009. PubMed |
| Nrf2 signaling and autophagy are complementary in protecting breast cancer cells during glucose deprivation. Walker A, Singh A, Tully E, Woo J, Le A, Nguyen T, Biswal S, Sharma D, Gabrielson E. Free Radic Biol Med. 2018 May 20;120:407-413. doi: 10.1016/j.freeradbiomed.2018.04.009. Epub 2018 Apr 9. PubMed |
| ERF deletion rescues RAS deficiency in mouse embryonic stem cells. Mayor-Ruiz C, Olbrich T, Drosten M, Lecona E, Vega-Sendino M, Ortega S, Dominguez O, Barbacid M, Ruiz S, Fernandez-Capetillo O. Genes Dev. 2018 Apr 1;32(7-8):568-576. doi: 10.1101/gad.310086.117. Epub 2018 Apr 12. PubMed |
| Nucleic acid-induced potentiation of matrix metalloproteinase-9 enzymatic activity. Duellman T, Chen X, Wakamiya R, Yang J. Biochem J. 2018 May 9;475(9):1597-1610. doi: 10.1042/BCJ20180035. PubMed |
| GCN2 deficiency ameliorates doxorubicin-induced cardiotoxicity by decreasing cardiomyocyte apoptosis and myocardial oxidative stress. Wang Y, Lei T, Yuan J, Wu Y, Shen X, Gao J, Feng W, Lu Z. Redox Biol. 2018 Jul;17:25-34. doi: 10.1016/j.redox.2018.04.009. Epub 2018 Apr 7. PubMed |
| STAG2 deficiency induces interferon responses via cGAS-STING pathway and restricts virus infection. Ding S, Diep J, Feng N, Ren L, Li B, Ooi YS, Wang X, Brulois KF, Yasukawa LL, Li X, Kuo CJ, Solomon DA, Carette JE, Greenberg HB. Nat Commun. 2018 Apr 16;9(1):1485. doi: 10.1038/s41467-018-03782-z. PubMed |
| USP9X Limits Mitotic Checkpoint Complex Turnover to Strengthen the Spindle Assembly Checkpoint and Guard against Chromosomal Instability. Skowyra A, Allan LA, Saurin AT, Clarke PR. Cell Rep. 2018 Apr 17;23(3):852-865. doi: 10.1016/j.celrep.2018.03.100. PubMed |
| Methylation-induced silencing of SPG20 facilitates gastric cancer cell proliferation by activating the EGFR/MAPK pathway. Zhou Z, Wang W, Xie X, Song Y, Dang C, Zhang H. Biochem Biophys Res Commun. 2018 Jun 2;500(2):411-417. doi: 10.1016/j.bbrc.2018.04.089. Epub 2018 Apr 18. PubMed |
| KREMEN1 Is a Host Entry Receptor for a Major Group of Enteroviruses. Staring J, van den Hengel LG, Raaben M, Blomen VA, Carette JE, Brummelkamp TR. Cell Host Microbe. 2018 May 9;23(5):636-643.e5. doi: 10.1016/j.chom.2018.03.019. Epub 2018 Apr 19. PubMed |
| Requirement of GSK-3 for PUMA induction upon loss of pro-survival PI3K signaling. Schubert F, Rapp J, Brauns-Schubert P, Schlicher L, Stock K, Wissler M, Weiss M, Charvet C, Borner C, Maurer U. Cell Death Dis. 2018 May 1;9(5):470. doi: 10.1038/s41419-018-0502-4. PubMed |
| The multiple myeloma risk allele at 5q15 lowers ELL2 expression and increases ribosomal gene expression. Ali M, Ajore R, Wihlborg AK, Niroula A, Swaminathan B, Johnsson E, Stephens OW, Morgan G, Meissner T, Turesson I, Goldschmidt H, Mellqvist UH, Gullberg U, Hansson M, Hemminki K, Nahi H, Waage A, Weinhold N, Nilsson B. Nat Commun. 2018 Apr 25;9(1):1649. doi: 10.1038/s41467-018-04082-2. PubMed |
| The GABAA Receptor beta Subunit Is Required for Inhibitory Transmission. Nguyen QA, Nicoll RA. Neuron. 2018 May 16;98(4):718-725.e3. doi: 10.1016/j.neuron.2018.03.046. Epub 2018 Apr 26. PubMed |
MicroRNA-focused CRISPR-Cas9 Library Screen Reveals Fitness-Associated miRNAs.
Kurata JS, Lin RJ.
RNA. 2018 May 2. pii: rna.066282.118. doi: 10.1261/rna.066282.118.
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| Imaging, myeloid precursor immortalization, and genome editing for defining mechanisms of leukocyte recruitment in vivo. Gran S, Honold L, Fehler O, Zenker S, Eligehausen S, Kuhlmann MT, Geven E, van den Bosch M, van Lent P, Spiekermann C, Hermann S, Vogl T, Schafers M, Roth J. Theranostics. 2018 Mar 23;8(9):2407-2423. doi: 10.7150/thno.23632. eCollection 2018. PubMed |
| Complimentary mechanisms of dual checkpoint blockade expand unique T-cell repertoires and activate adaptive anti-tumor immunity in triple-negative breast tumors. Crosby EJ, Wei J, Yang XY, Lei G, Wang T, Liu CX, Agarwal P, Korman AJ, Morse MA, Gouin K, Knott SRV, Lyerly HK, Hartman ZC. Oncoimmunology. 2018 Jan 19;7(5):e1421891. doi: 10.1080/2162402X.2017.1421891. eCollection 2018. PubMed |
| Myeloid beta-Catenin Deficiency Exacerbates Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient Mice. Wang F, Liu Z, Park SH, Gwag T, Lu W, Ma M, Sui Y, Zhou C. Arterioscler Thromb Vasc Biol. 2018 Jul;38(7):1468-1478. doi: 10.1161/ATVBAHA.118.311059. Epub 2018 May 3. PubMed |
| Towards Resolving the Pro- and Anti-Tumor Effects of the Aryl Hydrocarbon Receptor. Narasimhan S, Stanford Zulick E, Novikov O, Parks AJ, Schlezinger JJ, Wang Z, Laroche F, Feng H, Mulas F, Monti S, Sherr DH. Int J Mol Sci. 2018 May 7;19(5). pii: ijms19051388. doi: 10.3390/ijms19051388. PubMed |
| Essential Role of Linx/Islr2 in the Development of the Forebrain Anterior Commissure. Abudureyimu S, Asai N, Enomoto A, Weng L, Kobayashi H, Wang X, Chen C, Mii S, Takahashi M. Sci Rep. 2018 May 8;8(1):7292. doi: 10.1038/s41598-018-24064-0. PubMed |
| TGF-beta induces miR-100 and miR-125b but blocks let-7a through LIN28B controlling PDAC progression. Ottaviani S, Stebbing J, Frampton AE, Zagorac S, Krell J, de Giorgio A, Trabulo SM, Nguyen VTM, Magnani L, Feng H, Giovannetti E, Funel N, Gress TM, Jiao LR, Lombardo Y, Lemoine NR, Heeschen C, Castellano L. Nat Commun. 2018 May 10;9(1):1845. doi: 10.1038/s41467-018-03962-x. PubMed |
| Arginase 2 Suppresses Renal Carcinoma Progression via Biosynthetic Cofactor Pyridoxal Phosphate Depletion and Increased Polyamine Toxicity. Ochocki JD, Khare S, Hess M, Ackerman D, Qiu B, Daisak JI, Worth AJ, Lin N, Lee P, Xie H, Li B, Wubbenhorst B, Maguire TG, Nathanson KL, Alwine JC, Blair IA, Nissim I, Keith B, Simon MC. Cell Metab. 2018 Jun 5;27(6):1263-1280.e6. doi: 10.1016/j.cmet.2018.04.009. Epub 2018 May 10. PubMed |
| Mxra8 is a receptor for multiple arthritogenic alphaviruses. Zhang R, Kim AS, Fox JM, Nair S, Basore K, Klimstra WB, Rimkunas R, Fong RH, Lin H, Poddar S, Crowe JE Jr, Doranz BJ, Fremont DH, Diamond MS. Nature. 2018 May;557(7706):570-574. doi: 10.1038/s41586-018-0121-3. Epub 2018 May 16. PubMed |
| CRISPR/Cas9 system targeting regulatory genes of HIV-1 inhibits viral replication in infected T-cell cultures. Ophinni Y, Inoue M, Kotaki T, Kameoka M. Sci Rep. 2018 May 17;8(1):7784. doi: 10.1038/s41598-018-26190-1. PubMed |
| Transactivation domain of p53 regulates DNA repair and integrity in human iPS cells. Kannappan R, Mattapally S, Wagle PA, Zhang J. Am J Physiol Heart Circ Physiol. 2018 Sep 1;315(3):H512-H521. doi: 10.1152/ajpheart.00160.2018. Epub 2018 May 18. PubMed |
| The Bicarbonate Transporter SLC4A7 Plays a Key Role in Macrophage Phagosome Acidification. Sedlyarov V, Eichner R, Girardi E, Essletzbichler P, Goldmann U, Nunes-Hasler P, Srndic I, Moskovskich A, Heinz LX, Kartnig F, Bigenzahn JW, Rebsamen M, Kovarik P, Demaurex N, Superti-Furga G. Cell Host Microbe. 2018 Jun 13;23(6):766-774.e5. doi: 10.1016/j.chom.2018.04.013. Epub 2018 May 17. PubMed |
| The Eukaryotic Proteome Is Shaped by E3 Ubiquitin Ligases Targeting C-Terminal Degrons. Koren I, Timms RT, Kula T, Xu Q, Li MZ, Elledge SJ. Cell. 2018 Jun 14;173(7):1622-1635.e14. doi: 10.1016/j.cell.2018.04.028. Epub 2018 May 17. PubMed |
| TANK-binding kinase 1 and Janus kinase 2 play important roles in the regulation of mitogen-activated protein kinase phosphatase-1 expression after toll-like receptor 4 activation. Kim E, Yoon JY, Lee J, Jeong D, Park JG, Hong YH, Kim JH, Aravinthan A, Kim JH, Cho JY. J Cell Physiol. 2018 Nov;233(11):8790-8801. doi: 10.1002/jcp.26787. Epub 2018 May 24. PubMed |
| Partial Inactivation of the Chromatin Remodelers SMARCA2 and SMARCA4 in Virus-Infected Cells by Caspase-Mediated Cleavage. Dudek AH, Pfaff F, Bolte H, Waguia Kontchou C, Schwemmle M. J Virol. 2018 Jul 31;92(16). pii: JVI.00343-18. doi: 10.1128/JVI.00343-18. Print 2018 Aug 15. PubMed |
| CRISPR/Cas9 Genome Editing of Epidermal Growth Factor Receptor Sufficiently Abolished Oncogenicity in Anaplastic Thyroid Cancer. Huang LC, Tam KW, Liu WN, Lin CY, Hsu KW, Hsieh WS, Chi WM, Lee AW, Yang JM, Lin CL, Lee CH. Dis Markers. 2018 Apr 12;2018:3835783. doi: 10.1155/2018/3835783. eCollection 2018. PubMed |
| Inhibition of Wnt/beta-catenin signaling downregulates expression of aldehyde dehydrogenase isoform 3A1 (ALDH3A1) to reduce resistance against temozolomide in glioblastoma in vitro. Suwala AK, Koch K, Rios DH, Aretz P, Uhlmann C, Ogorek I, Felsberg J, Reifenberger G, Kohrer K, Deenen R, Steiger HJ, Kahlert UD, Maciaczyk J. Oncotarget. 2018 Apr 27;9(32):22703-22716. doi: 10.18632/oncotarget.25210. eCollection 2018 Apr 27. PubMed |
| Inhibition of the ER stress IRE1alpha inflammatory pathway protects against cell death in mitochondrial complex I mutant cells. Soustek MS, Balsa E, Barrow JJ, Jedrychowski M, Vogel R, Jan Smeitink, Gygi SP, Puigserver P. Cell Death Dis. 2018 May 31;9(6):658. doi: 10.1038/s41419-018-0696-5. PubMed |
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Associated Plasmids |
| Genome Editing of Human Primary Keratinocytes by CRISPR/Cas9 Reveals an Essential Role of the NLRP1 Inflammasome in UVB Sensing. Fenini G, Grossi S, Contassot E, Biedermann T, Reichmann E, French LE, Beer HD. J Invest Dermatol. 2018 Dec;138(12):2644-2652. doi: 10.1016/j.jid.2018.07.016. Epub 2018 Aug 7. PubMed |
| Pharmacological targeting of p38 MAP-Kinase 6 (MAP2K6) inhibits the growth of esophageal adenocarcinoma. Lin S, Liu K, Zhang Y, Jiang M, Lu R, Folts CJ, Gao X, Noble MD, Zhao T, Zhou Z, Lan X, Que J. Cell Signal. 2018 Nov;51:222-232. doi: 10.1016/j.cellsig.2018.08.008. Epub 2018 Aug 11. PubMed |
| Gambogic Acid and Its Analogs Inhibit Gap Junctional Intercellular Communication. Choi EJ, Yeo JH, Yoon SM, Lee J. Front Pharmacol. 2018 Jul 30;9:814. doi: 10.3389/fphar.2018.00814. eCollection 2018. PubMed |
| Tuning of human MAIT cell activation by commensal bacteria species and MR1-dependent T-cell presentation. Tastan C, Karhan E, Zhou W, Fleming E, Voigt AY, Yao X, Wang L, Horne M, Placek L, Kozhaya L, Oh J, Unutmaz D. Mucosal Immunol. 2018 Nov;11(6):1591-1605. doi: 10.1038/s41385-018-0072-x. Epub 2018 Aug 16. PubMed |
| Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1. Cha JH, Yang WH, Xia W, Wei Y, Chan LC, Lim SO, Li CW, Kim T, Chang SS, Lee HH, Hsu JL, Wang HL, Kuo CW, Chang WC, Hadad S, Purdie CA, McCoy AM, Cai S, Tu Y, Litton JK, Mittendorf EA, Moulder SL, Symmans WF, Thompson AM, Piwnica-Worms H, Chen CH, Khoo KH, Hung MC. Mol Cell. 2018 Aug 16;71(4):606-620.e7. doi: 10.1016/j.molcel.2018.07.030. PubMed |
| An Mtb-Human Protein-Protein Interaction Map Identifies a Switch between Host Antiviral and Antibacterial Responses. Penn BH, Netter Z, Johnson JR, Von Dollen J, Jang GM, Johnson T, Ohol YM, Maher C, Bell SL, Geiger K, Golovkine G, Du X, Choi A, Parry T, Mohapatra BC, Storck MD, Band H, Chen C, Jager S, Shales M, Portnoy DA, Hernandez R, Coscoy L, Cox JS, Krogan NJ. Mol Cell. 2018 Aug 16;71(4):637-648.e5. doi: 10.1016/j.molcel.2018.07.010. PubMed |
| A Role for p53 in the Adaptation to Glutamine Starvation through the Expression of SLC1A3. Tajan M, Hock AK, Blagih J, Robertson NA, Labuschagne CF, Kruiswijk F, Humpton TJ, Adams PD, Vousden KH. Cell Metab. 2018 Nov 6;28(5):721-736.e6. doi: 10.1016/j.cmet.2018.07.005. Epub 2018 Aug 16. PubMed |
| Cytosolic Aspartate Availability Determines Cell Survival When Glutamine Is Limiting. Alkan HF, Walter KE, Luengo A, Madreiter-Sokolowski CT, Stryeck S, Lau AN, Al-Zoughbi W, Lewis CA, Thomas CJ, Hoefler G, Graier WF, Madl T, Vander Heiden MG, Bogner-Strauss JG. Cell Metab. 2018 Nov 6;28(5):706-720.e6. doi: 10.1016/j.cmet.2018.07.021. Epub 2018 Aug 16. PubMed |
| Modified penetrance of coding variants by cis-regulatory variation contributes to disease risk. Castel SE, Cervera A, Mohammadi P, Aguet F, Reverter F, Wolman A, Guigo R, Iossifov I, Vasileva A, Lappalainen T. Nat Genet. 2018 Sep;50(9):1327-1334. doi: 10.1038/s41588-018-0192-y. Epub 2018 Aug 20. PubMed |
| Thioridazine inhibits self-renewal in breast cancer cells via DRD2-dependent STAT3 inhibition, but induces a G1 arrest independent of DRD2. Tegowski M, Fan C, Baldwin AS. J Biol Chem. 2018 Oct 12;293(41):15977-15990. doi: 10.1074/jbc.RA118.003719. Epub 2018 Aug 21. PubMed |
| Positive Regulation of Transcription by Human ZMYND8 through Its Association with P-TEFb Complex. Ghosh K, Tang M, Kumari N, Nandy A, Basu S, Mall DP, Rai K, Biswas D. Cell Rep. 2018 Aug 21;24(8):2141-2154.e6. doi: 10.1016/j.celrep.2018.07.064. PubMed |
| Genetic modifiers of the BRD4-NUT dependency of NUT midline carcinoma uncovers a synergism between BETis and CDK4/6is. Liao S, Maertens O, Cichowski K, Elledge SJ. Genes Dev. 2018 Sep 1;32(17-18):1188-1200. doi: 10.1101/gad.315648.118. Epub 2018 Aug 22. PubMed |
| MAIT cells protect against pulmonary Legionella longbeachae infection. Wang H, D'Souza C, Lim XY, Kostenko L, Pediongco TJ, Eckle SBG, Meehan BS, Shi M, Wang N, Li S, Liu L, Mak JYW, Fairlie DP, Iwakura Y, Gunnersen JM, Stent AW, Godfrey DI, Rossjohn J, Westall GP, Kjer-Nielsen L, Strugnell RA, McCluskey J, Corbett AJ, Hinks TSC, Chen Z. Nat Commun. 2018 Aug 22;9(1):3350. doi: 10.1038/s41467-018-05202-8. PubMed |
| RAP2 mediates mechanoresponses of the Hippo pathway. Meng Z, Qiu Y, Lin KC, Kumar A, Placone JK, Fang C, Wang KC, Lu S, Pan M, Hong AW, Moroishi T, Luo M, Plouffe SW, Diao Y, Ye Z, Park HW, Wang X, Yu FX, Chien S, Wang CY, Ren B, Engler AJ, Guan KL. Nature. 2018 Aug;560(7720):655-660. doi: 10.1038/s41586-018-0444-0. Epub 2018 Aug 22. PubMed |
| Dysregulated hemolysin liberates bacterial outer membrane vesicles for cytosolic lipopolysaccharide sensing. Chen S, Yang D, Wen Y, Jiang Z, Zhang L, Jiang J, Chen Y, Hu T, Wang Q, Zhang Y, Liu Q. PLoS Pathog. 2018 Aug 23;14(8):e1007240. doi: 10.1371/journal.ppat.1007240. eCollection 2018 Aug. PubMed |
| CUEDC1 is a primary target of ERalpha essential for the growth of breast cancer cells. Lopes R, Korkmaz G, Revilla SA, van Vliet R, Nagel R, Custers L, Kim Y, van Breugel PC, Zwart W, Moumbeini B, Manber Z, Elkon R, Agami R. Cancer Lett. 2018 Nov 1;436:87-95. doi: 10.1016/j.canlet.2018.08.018. Epub 2018 Aug 23. PubMed |
| TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging. Xu D, Jin T, Zhu H, Chen H, Ofengeim D, Zou C, Mifflin L, Pan L, Amin P, Li W, Shan B, Naito MG, Meng H, Li Y, Pan H, Aron L, Adiconis X, Levin JZ, Yankner BA, Yuan J. Cell. 2018 Sep 6;174(6):1477-1491.e19. doi: 10.1016/j.cell.2018.07.041. Epub 2018 Aug 23. PubMed |
| Human tryptophanyl-tRNA synthetase is an IFN-gamma-inducible entry factor for Enterovirus. Yeung ML, Jia L, Yip CCY, Chan JFW, Teng JLL, Chan KH, Cai JP, Zhang C, Zhang AJ, Wong WM, Kok KH, Lau SKP, Woo PCY, Lo JYC, Jin DY, Shih SR, Yuen KY. J Clin Invest. 2018 Nov 1;128(11):5163-5177. doi: 10.1172/JCI99411. Epub 2018 Oct 15. PubMed |
| Transcription Factor PROX1 Suppresses Notch Pathway Activation via the Nucleosome Remodeling and Deacetylase Complex in Colorectal Cancer Stem-like Cells. Hogstrom J, Heino S, Kallio P, Lahde M, Leppanen VM, Balboa D, Wiener Z, Alitalo K. Cancer Res. 2018 Oct 15;78(20):5820-5832. doi: 10.1158/0008-5472.CAN-18-0451. Epub 2018 Aug 28. PubMed |
| The LTB4-BLT1 axis regulates the polarized trafficking of chemoattractant GPCRs during neutrophil chemotaxis. Subramanian BC, Moissoglu K, Parent CA. J Cell Sci. 2018 Sep 21;131(18). pii: jcs.217422. doi: 10.1242/jcs.217422. PubMed |
| Nrf2 negatively regulates STING indicating a link between antiviral sensing and metabolic reprogramming. Olagnier D, Brandtoft AM, Gunderstofte C, Villadsen NL, Krapp C, Thielke AL, Laustsen A, Peri S, Hansen AL, Bonefeld L, Thyrsted J, Bruun V, Iversen MB, Lin L, Artegoitia VM, Su C, Yang L, Lin R, Balachandran S, Luo Y, Nyegaard M, Marrero B, Goldbach-Mansky R, Motwani M, Ryan DG, Fitzgerald KA, O'Neill LA, Hollensen AK, Damgaard CK, de Paoli FV, Bertram HC, Jakobsen MR, Poulsen TB, Holm CK. Nat Commun. 2018 Aug 29;9(1):3506. doi: 10.1038/s41467-018-05861-7. PubMed |
| RNF144A sustains EGFR signaling to promote EGF-dependent cell proliferation. Ho SR, Lin WC. J Biol Chem. 2018 Oct 19;293(42):16307-16323. doi: 10.1074/jbc.RA118.002887. Epub 2018 Aug 31. PubMed |
| Protease-activated receptor 2 (PAR2) upregulates granulocyte colony stimulating factor (G-CSF) expression in breast cancer cells. Carvalho E, Hugo de Almeida V, Rondon AMR, Possik PA, Viola JPB, Monteiro RQ. Biochem Biophys Res Commun. 2018 Sep 26;504(1):270-276. doi: 10.1016/j.bbrc.2018.08.169. Epub 2018 Aug 30. PubMed |
| Epigenetic and Transcriptomic Profiling of Mammary Gland Development and Tumor Models Disclose Regulators of Cell State Plasticity. Dravis C, Chung CY, Lytle NK, Herrera-Valdez J, Luna G, Trejo CL, Reya T, Wahl GM. Cancer Cell. 2018 Sep 10;34(3):466-482.e6. doi: 10.1016/j.ccell.2018.08.001. Epub 2018 Aug 30. PubMed |
| Microbiota-derived short-chain fatty acids promote Th1 cell IL-10 production to maintain intestinal homeostasis. Sun M, Wu W, Chen L, Yang W, Huang X, Ma C, Chen F, Xiao Y, Zhao Y, Ma C, Yao S, Carpio VH, Dann SM, Zhao Q, Liu Z, Cong Y. Nat Commun. 2018 Sep 3;9(1):3555. doi: 10.1038/s41467-018-05901-2. PubMed |
| Local enrichment of HP1alpha at telomeres alters their structure and regulation of telomere protection. Chow TT, Shi X, Wei JH, Guan J, Stadler G, Huang B, Blackburn EH. Nat Commun. 2018 Sep 4;9(1):3583. doi: 10.1038/s41467-018-05840-y. PubMed |
| Sphingosine-1-phosphate (S1P) induces potent anti-inflammatory effects in vitro and in vivo by S1P receptor 4-mediated suppression of 5-lipoxygenase activity. Fettel J, Kuhn B, Guillen NA, Surun D, Peters M, Bauer R, Angioni C, Geisslinger G, Schnutgen F, Meyer Zu Heringdorf D, Werz O, Meybohm P, Zacharowski K, Steinhilber D, Roos J, Maier TJ. FASEB J. 2019 Feb;33(2):1711-1726. doi: 10.1096/fj.201800221R. Epub 2018 Sep 6. PubMed |
Interrogating the protein interactomes of RAS isoforms identifies PIP5K1A as a KRAS-specific vulnerability.
Adhikari H, Counter CM.
Nat Commun. 2018 Sep 7;9(1):3646. doi: 10.1038/s41467-018-05692-6.
PubMed
Associated Plasmids |
| Inducing CCR5Delta32/Delta32 Homozygotes in the Human Jurkat CD4+ Cell Line and Primary CD4+ Cells by CRISPR-Cas9 Genome-Editing Technology. Qi C, Li D, Jiang X, Jia X, Lu L, Wang Y, Sun J, Shao Y, Wei M. Mol Ther Nucleic Acids. 2018 Sep 7;12:267-274. doi: 10.1016/j.omtn.2018.05.012. Epub 2018 Jun 17. PubMed |
| Ex Vivo COL7A1 Correction for Recessive Dystrophic Epidermolysis Bullosa Using CRISPR/Cas9 and Homology-Directed Repair. Izmiryan A, Ganier C, Bovolenta M, Schmitt A, Mavilio F, Hovnanian A. Mol Ther Nucleic Acids. 2018 Sep 7;12:554-567. doi: 10.1016/j.omtn.2018.06.008. Epub 2018 Jun 26. PubMed |
BAP1 links metabolic regulation of ferroptosis to tumour suppression.
Zhang Y, Shi J, Liu X, Feng L, Gong Z, Koppula P, Sirohi K, Li X, Wei Y, Lee H, Zhuang L, Chen G, Xiao ZD, Hung MC, Chen J, Huang P, Li W, Gan B.
Nat Cell Biol. 2018 Oct;20(10):1181-1192. doi: 10.1038/s41556-018-0178-0. Epub 2018 Sep 10.
PubMed
Associated Plasmids |
| Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma. McBrayer SK, Mayers JR, DiNatale GJ, Shi DD, Khanal J, Chakraborty AA, Sarosiek KA, Briggs KJ, Robbins AK, Sewastianik T, Shareef SJ, Olenchock BA, Parker SJ, Tateishi K, Spinelli JB, Islam M, Haigis MC, Looper RE, Ligon KL, Bernstein BE, Carrasco RD, Cahill DP, Asara JM, Metallo CM, Yennawar NH, Vander Heiden MG, Kaelin WG Jr. Cell. 2018 Sep 20;175(1):101-116.e25. doi: 10.1016/j.cell.2018.08.038. Epub 2018 Sep 13. PubMed |
| Ubiquitin ligase RNF8 suppresses Notch signaling to regulate mammary development and tumorigenesis. Li L, Guturi KKN, Gautreau B, Patel PS, Saad A, Morii M, Mateo F, Palomero L, Barbour H, Gomez A, Ng D, Kotlyar M, Pastrello C, Jackson HW, Khokha R, Jurisica I, Affar EB, Raught B, Sanchez O, Alaoui-Jamali M, Pujana MA, Hakem A, Hakem R. J Clin Invest. 2018 Oct 1;128(10):4525-4542. doi: 10.1172/JCI120401. Epub 2018 Aug 2. PubMed |
| Recurrent WNT pathway alterations are frequent in relapsed small cell lung cancer. Wagner AH, Devarakonda S, Skidmore ZL, Krysiak K, Ramu A, Trani L, Kunisaki J, Masood A, Waqar SN, Spies NC, Morgensztern D, Waligorski J, Ponce J, Fulton RS, Maggi LB Jr, Weber JD, Watson MA, O'Conor CJ, Ritter JH, Olsen RR, Cheng H, Mukhopadhyay A, Can I, Cessna MH, Oliver TG, Mardis ER, Wilson RK, Griffith M, Griffith OL, Govindan R. Nat Commun. 2018 Sep 17;9(1):3787. doi: 10.1038/s41467-018-06162-9. PubMed |
| A CRISPR screen identifies IFI6 as an ER-resident interferon effector that blocks flavivirus replication. Richardson RB, Ohlson MB, Eitson JL, Kumar A, McDougal MB, Boys IN, Mar KB, De La Cruz-Rivera PC, Douglas C, Konopka G, Xing C, Schoggins JW. Nat Microbiol. 2018 Nov;3(11):1214-1223. doi: 10.1038/s41564-018-0244-1. Epub 2018 Sep 17. PubMed |
| Functional Silencing of HSD17B2 in Prostate Cancer Promotes Disease Progression. Gao X, Dai C, Huang S, Tang J, Chen G, Li J, Zhu Z, Zhu X, Zhou S, Gao Y, Hou Z, Fang Z, Xu C, Wang J, Wu D, Sharifi N, Li Z. Clin Cancer Res. 2019 Feb 15;25(4):1291-1301. doi: 10.1158/1078-0432.CCR-18-2392. Epub 2018 Sep 18. PubMed |
| Systematic genetic mapping of necroptosis identifies SLC39A7 as modulator of death receptor trafficking. Fauster A, Rebsamen M, Willmann KL, Cesar-Razquin A, Girardi E, Bigenzahn JW, Schischlik F, Scorzoni S, Bruckner M, Konecka J, Hormann K, Heinz LX, Boztug K, Superti-Furga G. Cell Death Differ. 2018 Sep 20. pii: 10.1038/s41418-018-0192-6. doi: 10.1038/s41418-018-0192-6. PubMed |
| Biallelic mutations in human NHLRC2 enhance myofibroblast differentiation in FINCA disease. Paakkola T, Salokas K, Miinalainen I, Lehtonen S, Manninen A, Kaakinen M, Ruddock LW, Varjosalo M, Kaarteenaho R, Uusimaa J, Hinttala R. Hum Mol Genet. 2018 Dec 15;27(24):4288-4302. doi: 10.1093/hmg/ddy298. PubMed |
| Acetate Production from Glucose and Coupling to Mitochondrial Metabolism in Mammals. Liu X, Cooper DE, Cluntun AA, Warmoes MO, Zhao S, Reid MA, Liu J, Lund PJ, Lopes M, Garcia BA, Wellen KE, Kirsch DG, Locasale JW. Cell. 2018 Oct 4;175(2):502-513.e13. doi: 10.1016/j.cell.2018.08.040. Epub 2018 Sep 20. PubMed |
| Disruption of the superoxide anions-mitophagy regulation axis mediates copper oxide nanoparticles-induced vascular endothelial cell death. Zhang J, Wang B, Wang H, He H, Wu Q, Qin X, Yang X, Chen L, Xu G, Yuan Z, Yi Q, Zou Z, Yu C. Free Radic Biol Med. 2018 Dec;129:268-278. doi: 10.1016/j.freeradbiomed.2018.09.032. Epub 2018 Sep 21. PubMed |
| The cargo receptor SURF4 promotes the efficient cellular secretion of PCSK9. Emmer BT, Hesketh GG, Kotnik E, Tang VT, Lascuna PJ, Xiang J, Gingras AC, Chen XW, Ginsburg D. Elife. 2018 Sep 25;7. pii: 38839. doi: 10.7554/eLife.38839. PubMed |
| Loss of dihydrotestosterone-inactivation activity promotes prostate cancer castration resistance detectable by functional imaging. Zhu Z, Chung YM, Sergeeva O, Kepe V, Berk M, Li J, Ko HK, Li Z, Petro M, DiFilippo FP, Lee Z, Sharifi N. J Biol Chem. 2018 Nov 16;293(46):17829-17837. doi: 10.1074/jbc.RA118.004846. Epub 2018 Sep 27. PubMed |
| Infection-Induced Peroxisome Biogenesis Is a Metabolic Strategy for Herpesvirus Replication. Jean Beltran PM, Cook KC, Hashimoto Y, Galitzine C, Murray LA, Vitek O, Cristea IM. Cell Host Microbe. 2018 Oct 10;24(4):526-541.e7. doi: 10.1016/j.chom.2018.09.002. Epub 2018 Sep 27. PubMed |
NONO Detects the Nuclear HIV Capsid to Promote cGAS-Mediated Innate Immune Activation.
Lahaye X, Gentili M, Silvin A, Conrad C, Picard L, Jouve M, Zueva E, Maurin M, Nadalin F, Knott GJ, Zhao B, Du F, Rio M, Amiel J, Fox AH, Li P, Etienne L, Bond CS, Colleaux L, Manel N.
Cell. 2018 Oct 4;175(2):488-501.e22. doi: 10.1016/j.cell.2018.08.062. Epub 2018 Sep 27.
PubMed
Associated Plasmids |
| The DEAD-box RNA-binding protein DDX6 regulates parental RNA decay for cellular reprogramming to pluripotency. Kami D, Kitani T, Nakamura A, Wakui N, Mizutani R, Ohue M, Kametani F, Akimitsu N, Gojo S. PLoS One. 2018 Oct 1;13(10):e0203708. doi: 10.1371/journal.pone.0203708. eCollection 2018. PubMed |
| Role of PDGF receptor-alpha during human cytomegalovirus entry into fibroblasts. Wu K, Oberstein A, Wang W, Shenk T. Proc Natl Acad Sci U S A. 2018 Oct 16;115(42):E9889-E9898. doi: 10.1073/pnas.1806305115. Epub 2018 Oct 1. PubMed |
| Analysis of chromatin accessibility uncovers TEAD1 as a regulator of migration in human glioblastoma. Tome-Garcia J, Erfani P, Nudelman G, Tsankov AM, Katsyv I, Tejero R, Bin Zhang, Walsh M, Friedel RH, Zaslavsky E, Tsankova NM. Nat Commun. 2018 Oct 1;9(1):4020. doi: 10.1038/s41467-018-06258-2. PubMed |
| Membrane associated collagen XIII promotes cancer metastasis and enhances anoikis resistance. Zhang H, Fredericks T, Xiong G, Qi Y, Rychahou PG, Li JD, Pihlajaniemi T, Xu W, Xu R. Breast Cancer Res. 2018 Oct 1;20(1):116. doi: 10.1186/s13058-018-1030-y. PubMed |
| Targeting peroxiredoxin 1 impairs growth of breast cancer cells and potently sensitises these cells to prooxidant agents. Bajor M, Zych AO, Graczyk-Jarzynka A, Muchowicz A, Firczuk M, Trzeciak L, Gaj P, Domagala A, Siernicka M, Zagozdzon A, Siedlecki P, Kniotek M, O'Leary PC, Golab J, Zagozdzon R. Br J Cancer. 2018 Oct;119(7):873-884. doi: 10.1038/s41416-018-0263-y. Epub 2018 Oct 5. PubMed |
| Human genetic variation in GLS2 is associated with development of complicated Staphylococcus aureus bacteremia. Scott WK, Medie FM, Ruffin F, Sharma-Kuinkel BK, Cyr DD, Guo S, Dykxhoorn DM, Skov RL, Bruun NE, Dahl A, Lerche CJ, Petersen A, Larsen AR, Lauridsen TK, Johansen HK, Ullum H, Sorensen E, Hassager C, Bundgaard H, Schonheyder HC, Torp-Pedersen C, Ostergaard LB, Arpi M, Rosenvinge F, Erikstrup LT, Chehri M, Sogaard P, Andersen PS, Fowler VG Jr. PLoS Genet. 2018 Oct 5;14(10):e1007667. doi: 10.1371/journal.pgen.1007667. eCollection 2018 Oct. PubMed |
| Adducins inhibit lung cancer cell migration through mechanisms involving regulation of cell-matrix adhesion and cadherin-11 expression. Lechuga S, Amin PH, Wolen AR, Ivanov AI. Biochim Biophys Acta Mol Cell Res. 2019 Mar;1866(3):395-408. doi: 10.1016/j.bbamcr.2018.10.001. Epub 2018 Oct 2. PubMed |
| Exon Skipping in a Dysf-Missense Mutant Mouse Model. Malcher J, Heidt L, Goyenvalle A, Escobar H, Marg A, Beley C, Benchaouir R, Bader M, Spuler S, Garcia L, Schowel V. Mol Ther Nucleic Acids. 2018 Dec 7;13:198-207. doi: 10.1016/j.omtn.2018.08.013. Epub 2018 Aug 22. PubMed |
| Genetic Modulation of RNA Splicing with a CRISPR-Guided Cytidine Deaminase. Yuan J, Ma Y, Huang T, Chen Y, Peng Y, Li B, Li J, Zhang Y, Song B, Sun X, Ding Q, Song Y, Chang X. Mol Cell. 2018 Oct 18;72(2):380-394.e7. doi: 10.1016/j.molcel.2018.09.002. Epub 2018 Oct 4. PubMed |
| RAD9A promotes metastatic phenotypes through transcriptional regulation of anterior gradient 2 (AGR2). Broustas CG, Hopkins KM, Panigrahi SK, Wang L, Virk RK, Lieberman HB. Carcinogenesis. 2019 Mar 12;40(1):164-172. doi: 10.1093/carcin/bgy131. PubMed |
| A RECK-WNT7 Receptor-Ligand Interaction Enables Isoform-Specific Regulation of Wnt Bioavailability. Vallon M, Yuki K, Nguyen TD, Chang J, Yuan J, Siepe D, Miao Y, Essler M, Noda M, Garcia KC, Kuo CJ. Cell Rep. 2018 Oct 9;25(2):339-349.e9. doi: 10.1016/j.celrep.2018.09.045. PubMed |
| Long noncoding RNA C21orf121/bone morphogenetic protein 2/microRNA-140-5p gene network promotes directed differentiation of stem cells from human exfoliated deciduous teeth to neuronal cells. Liu J, Zhang ZY, Yu H, Yang AP, Hu PF, Liu Z, Wang M. J Cell Biochem. 2018 Oct 14. doi: 10.1002/jcb.27313. PubMed |
| Phosphorylation of TRIM28 Enhances the Expression of IFN-beta and Proinflammatory Cytokines During HPAIV Infection of Human Lung Epithelial Cells. Krischuns T, Gunl F, Henschel L, Binder M, Willemsen J, Schloer S, Rescher U, Gerlt V, Zimmer G, Nordhoff C, Ludwig S, Brunotte L. Front Immunol. 2018 Sep 28;9:2229. doi: 10.3389/fimmu.2018.02229. eCollection 2018. PubMed |
| Enzyme promiscuity drives branched-chain fatty acid synthesis in adipose tissues. Wallace M, Green CR, Roberts LS, Lee YM, McCarville JL, Sanchez-Gurmaches J, Meurs N, Gengatharan JM, Hover JD, Phillips SA, Ciaraldi TP, Guertin DA, Cabrales P, Ayres JS, Nomura DK, Loomba R, Metallo CM. Nat Chem Biol. 2018 Nov;14(11):1021-1031. doi: 10.1038/s41589-018-0132-2. Epub 2018 Oct 16. PubMed |
The Lineage-Defining Transcription Factors SOX2 and NKX2-1 Determine Lung Cancer Cell Fate and Shape the Tumor Immune Microenvironment.
Mollaoglu G, Jones A, Wait SJ, Mukhopadhyay A, Jeong S, Arya R, Camolotto SA, Mosbruger TL, Stubben CJ, Conley CJ, Bhutkar A, Vahrenkamp JM, Berrett KC, Cessna MH, Lane TE, Witt BL, Salama ME, Gertz J, Jones KB, Snyder EL, Oliver TG.
Immunity. 2018 Oct 16;49(4):764-779.e9. doi: 10.1016/j.immuni.2018.09.020.
PubMed
Associated Plasmids |
| PRMT6 Regulates RAS/RAF Binding and MEK/ERK-Mediated Cancer Stemness Activities in Hepatocellular Carcinoma through CRAF Methylation. Chan LH, Zhou L, Ng KY, Wong TL, Lee TK, Sharma R, Loong JH, Ching YP, Yuan YF, Xie D, Lo CM, Man K, Artegiani B, Clevers H, Yan HH, Leung SY, Richard S, Guan XY, Huen MSY, Ma S. Cell Rep. 2018 Oct 16;25(3):690-701.e8. doi: 10.1016/j.celrep.2018.09.053. PubMed |
| Transposon mutagenesis screen in mice identifies TM9SF2 as a novel colorectal cancer oncogene. Clark CR, Maile M, Blaney P, Hellweg SR, Strauss A, Durose W, Priya S, Habicht J, Burns MB, Blekhman R, Abrahante JE, Starr TK. Sci Rep. 2018 Oct 17;8(1):15327. doi: 10.1038/s41598-018-33527-3. PubMed |
| STIM2 interacts with AMPK and regulates calcium-induced AMPK activation. Chauhan AS, Liu X, Jing J, Lee H, Yadav RK, Liu J, Zhou Y, Gan B. FASEB J. 2019 Feb;33(2):2957-2970. doi: 10.1096/fj.201801225R. Epub 2018 Oct 18. PubMed |
| The Nedd8-activating enzyme inhibitor MLN4924 (TAK-924/Pevonedistat) induces apoptosis via c-Myc-Noxa axis in head and neck squamous cell carcinoma. Zhang W, Liang Y, Li L, Wang X, Yan Z, Dong C, Zeng MS, Zhong Q, Liu XK, Yu J, Sun S, Liu X, Kang J, Zhao H, Jeong LS, Zhang Y, Jia L. Cell Prolif. 2019 Mar;52(2):e12536. doi: 10.1111/cpr.12536. Epub 2018 Oct 19. PubMed |
| Dimerization of an aptamer generated from Ligand-guided selection (LIGS) yields a high affinity scaffold against B-cells. Batool S, Argyropoulos KV, Azad R, Okeoma P, Zumrut H, Bhandari S, Dekhang R, Mallikaratchy PR. Biochim Biophys Acta Gen Subj. 2019 Jan;1863(1):232-240. doi: 10.1016/j.bbagen.2018.10.006. Epub 2018 Oct 17. PubMed |
Protein Barcodes Enable High-Dimensional Single-Cell CRISPR Screens.
Wroblewska A, Dhainaut M, Ben-Zvi B, Rose SA, Park ES, Amir ED, Bektesevic A, Baccarini A, Merad M, Rahman AH, Brown BD.
Cell. 2018 Nov 1;175(4):1141-1155.e16. doi: 10.1016/j.cell.2018.09.022. Epub 2018 Oct 18.
PubMed
Associated Plasmids |
| Cyclophilin J limits inflammation through the blockage of ubiquitin chain sensing. Sheng C, Yao C, Wang Z, Chen H, Zhao Y, Xu D, Huang H, Huang W, Chen S. Nat Commun. 2018 Oct 22;9(1):4381. doi: 10.1038/s41467-018-06756-3. PubMed |
| Monoubiquitination of ASXLs controls the deubiquitinase activity of the tumor suppressor BAP1. Daou S, Barbour H, Ahmed O, Masclef L, Baril C, Sen Nkwe N, Tchelougou D, Uriarte M, Bonneil E, Ceccarelli D, Mashtalir N, Tanji M, Masson JY, Thibault P, Sicheri F, Yang H, Carbone M, Therrien M, Affar EB. Nat Commun. 2018 Oct 22;9(1):4385. doi: 10.1038/s41467-018-06854-2. PubMed |
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| Unique, Intersecting, and Overlapping Roles of C/EBP beta and CREB in Cells of the Innate Immune System. Larabee JL, Hauck G, Ballard JD. Sci Rep. 2018 Nov 16;8(1):16931. doi: 10.1038/s41598-018-35184-y. PubMed |
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| Asymmetric dimethylation at histone H3 arginine 2 by PRMT6 in gastric cancer progression. Okuno K, Akiyama Y, Shimada S, Nakagawa M, Tanioka T, Inokuchi M, Yamaoka S, Kojima K, Tanaka S. Carcinogenesis. 2019 Mar 12;40(1):15-26. doi: 10.1093/carcin/bgy147. PubMed |
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CRISPR-C: circularization of genes and chromosome by CRISPR in human cells.
Moller HD, Lin L, Xiang X, Petersen TS, Huang J, Yang L, Kjeldsen E, Jensen UB, Zhang X, Liu X, Xu X, Wang J, Yang H, Church GM, Bolund L, Regenberg B, Luo Y.
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| Loss of KDM6A characterizes a poor prognostic subtype of human pancreatic cancer and potentiates HDAC inhibitor lethality. Watanabe S, Shimada S, Akiyama Y, Ishikawa Y, Ogura T, Ogawa K, Ono H, Mitsunori Y, Ban D, Kudo A, Yamaoka S, Tanabe M, Tanaka S. Int J Cancer. 2018 Dec 17. doi: 10.1002/ijc.32072. PubMed |
| The ASCIZ-DYNLL1 axis promotes 53BP1-dependent non-homologous end joining and PARP inhibitor sensitivity. Becker JR, Cuella-Martin R, Barazas M, Liu R, Oliveira C, Oliver AW, Bilham K, Holt AB, Blackford AN, Heierhorst J, Jonkers J, Rottenberg S, Chapman JR. Nat Commun. 2018 Dec 17;9(1):5406. doi: 10.1038/s41467-018-07855-x. PubMed |
| Proteasomal degradation of NOD2 by NLRP12 in monocytes promotes bacterial tolerance and colonization by enteropathogens. Normand S, Waldschmitt N, Neerincx A, Martinez-Torres RJ, Chauvin C, Couturier-Maillard A, Boulard O, Cobret L, Awad F, Huot L, Ribeiro-Ribeiro A, Lautz K, Ruez R, Delacre M, Bondu C, Guilliams M, Scott C, Segal A, Amselem S, Hot D, Karabina S, Bohn E, Ryffel B, Poulin LF, Kufer TA, Chamaillard M. Nat Commun. 2018 Dec 17;9(1):5338. doi: 10.1038/s41467-018-07750-5. PubMed |
| CRISPR-Mediated Approaches to Regulate YAP/TAZ Levels. Quinton RJ, Ganem NJ. Methods Mol Biol. 2019;1893:203-214. doi: 10.1007/978-1-4939-8910-2_16. PubMed |
| Polarization of Human Macrophages by Interleukin-4 Does Not Require ATP-Citrate Lyase. Namgaladze D, Zukunft S, Schnutgen F, Kurrle N, Fleming I, Fuhrmann D, Brune B. Front Immunol. 2018 Dec 4;9:2858. doi: 10.3389/fimmu.2018.02858. eCollection 2018. PubMed |
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| High cortactin expression in B-cell acute lymphoblastic leukemia is associated with increased transendothelial migration and bone marrow relapse. Velazquez-Avila M, Balandran JC, Ramirez-Ramirez D, Velazquez-Avila M, Sandoval A, Felipe-Lopez A, Nava P, Alvarado-Moreno JA, Dozal D, Prieto-Chavez JL, Schaks M, Rottner K, Dorantes-Acosta E, Lopez-Martinez B, Schnoor M, Pelayo R. Leukemia. 2018 Dec 20. pii: 10.1038/s41375-018-0333-4. doi: 10.1038/s41375-018-0333-4. PubMed |
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Optimized libraries for CRISPR-Cas9 genetic screens with multiple modalities.
Sanson KR, Hanna RE, Hegde M, Donovan KF, Strand C, Sullender ME, Vaimberg EW, Goodale A, Root DE, Piccioni F, Doench JG.
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| p62/SQSTM1 Fuels Melanoma Progression by Opposing mRNA Decay of a Selective Set of Pro-metastatic Factors. Karras P, Riveiro-Falkenbach E, Canon E, Tejedo C, Calvo TG, Martinez-Herranz R, Alonso-Curbelo D, Cifdaloz M, Perez-Guijarro E, Gomez-Lopez G, Ximenez-Embun P, Munoz J, Megias D, Olmeda D, Moscat J, Ortiz-Romero PL, Rodriguez-Peralto JL, Soengas MS. Cancer Cell. 2019 Jan 14;35(1):46-63.e10. doi: 10.1016/j.ccell.2018.11.008. Epub 2018 Dec 20. PubMed |
| Preclinical Development of Bivalent Chimeric Antigen Receptors Targeting Both CD19 and CD22. Qin H, Ramakrishna S, Nguyen S, Fountaine TJ, Ponduri A, Stetler-Stevenson M, Yuan CM, Haso W, Shern JF, Shah NN, Fry TJ. Mol Ther Oncolytics. 2018 Nov 6;11:127-137. doi: 10.1016/j.omto.2018.10.006. eCollection 2018 Dec 21. PubMed |
| The Interaction between Laminin-332 and alpha3beta1 Integrin Determines Differentiation and Maintenance of CAFs, and Supports Invasion of Pancreatic Duct Adenocarcinoma Cells. Cavaco ACM, Rezaei M, Caliandro MF, Lima AM, Stehling M, Dhayat SA, Haier J, Brakebusch C, Eble JA. Cancers (Basel). 2018 Dec 21;11(1). pii: cancers11010014. doi: 10.3390/cancers11010014. PubMed |
| Replisome Dynamics and Their Functional Relevance upon DNA Damage through the PCNA Interactome. Srivastava M, Chen Z, Zhang H, Tang M, Wang C, Jung SY, Chen J. Cell Rep. 2018 Dec 26;25(13):3869-3883.e4. doi: 10.1016/j.celrep.2018.11.099. PubMed |
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| APIM-Mediated REV3L(-)PCNA Interaction Important for Error Free TLS Over UV-Induced DNA Lesions in Human Cells. Raeder SB, Nepal A, Bjoras KO, Seelinger M, Kolve RS, Nedal A, Muller R, Otterlei M. Int J Mol Sci. 2018 Dec 28;20(1). pii: ijms20010100. doi: 10.3390/ijms20010100. PubMed |
| SG formation relies on eIF4GI-G3BP interaction which is targeted by picornavirus stress antagonists. Yang X, Hu Z, Zhang Q, Fan S, Zhong Y, Guo D, Qin Y, Chen M. Cell Discov. 2019 Jan 1;5:1. doi: 10.1038/s41421-018-0068-4. eCollection 2019. PubMed |
| Targeting B7-H1 (PD-L1) sensitizes cancer cells to chemotherapy. Wu X, Li Y, Liu X, Chen C, Harrington SM, Cao S, Xie T, Orzechowski A, Pham T, Mansfield AS, Yan Y, Kwon ED, Wang L, Ling K, Dong H. Heliyon. 2018 Dec 18;4(12):e01039. doi: 10.1016/j.heliyon.2018.e01039. eCollection 2018 Dec. PubMed |
| Establishment of TP53-knockout canine cells using optimized CRIPSR/Cas9 vector system for canine cancer research. Eun K, Park MG, Jeong YW, Jeong YI, Hyun SH, Hwang WS, Kim SH, Kim H. BMC Biotechnol. 2019 Jan 3;19(1):1. doi: 10.1186/s12896-018-0491-5. PubMed |
| Mutations of ADAMTS9 Cause Nephronophthisis-Related Ciliopathy. Choi YJ, Halbritter J, Braun DA, Schueler M, Schapiro D, Rim JH, Nandadasa S, Choi WI, Widmeier E, Shril S, Korber F, Sethi SK, Lifton RP, Beck BB, Apte SS, Gee HY, Hildebrandt F. Am J Hum Genet. 2019 Jan 3;104(1):45-54. doi: 10.1016/j.ajhg.2018.11.003. PubMed |
| Vitamin D3 activates the autolysosomal degradation function against Helicobacter pylori through the PDIA3 receptor in gastric epithelial cells. Hu W, Zhang L, Li MX, Shen J, Liu XD, Xiao ZG, Wu DL, Ho IHT, Wu JCY, Cheung CKY, Zhang YC, Lau AHY, Ashktorab H, Smoot DT, Fang EF, Chan MTV, Gin T, Gong W, Wu WKK, Cho CH. Autophagy. 2019 Apr;15(4):707-725. doi: 10.1080/15548627.2018.1557835. Epub 2019 Jan 6. PubMed |
| METTL13 Methylation of eEF1A Increases Translational Output to Promote Tumorigenesis. Liu S, Hausmann S, Carlson SM, Fuentes ME, Francis JW, Pillai R, Lofgren SM, Hulea L, Tandoc K, Lu J, Li A, Nguyen ND, Caporicci M, Kim MP, Maitra A, Wang H, Wistuba II, Porco JA Jr, Bassik MC, Elias JE, Song J, Topisirovic I, Van Rechem C, Mazur PK, Gozani O. Cell. 2019 Jan 24;176(3):491-504.e21. doi: 10.1016/j.cell.2018.11.038. Epub 2019 Jan 3. PubMed |
| Genetic Models of Calpain Deficiency and Ectopic Expression. Gao Y, Hall C, MacLeod J, Greer PA. Methods Mol Biol. 2019;1915:261-274. doi: 10.1007/978-1-4939-8988-1_20. PubMed |
| Identification of Clotrimazole Derivatives as Specific Inhibitors of Arenavirus Fusion. Torriani G, Trofimenko E, Mayor J, Fedeli C, Moreno H, Michel S, Heulot M, Chevalier N, Zimmer G, Shrestha N, Plattet P, Engler O, Rothenberger S, Widmann C, Kunz S. J Virol. 2019 Mar 5;93(6). pii: JVI.01744-18. doi: 10.1128/JVI.01744-18. Print 2019 Mar 15. PubMed |
| TGF-beta-induced alternative splicing of TAK1 promotes EMT and drug resistance. Tripathi V, Shin JH, Stuelten CH, Zhang YE. Oncogene. 2019 Apr;38(17):3185-3200. doi: 10.1038/s41388-018-0655-8. Epub 2019 Jan 9. PubMed |
| Defective AP-3-dependent VAMP8 trafficking impairs Weibel-Palade body exocytosis in Hermansky-Pudlak Syndrome type 2 blood outgrowth endothelial cells. Karampini E, Schillemans M, Hofman M, van Alphen F, de Boer M, Kuijpers TW, van den Biggelaar M, Voorberg J, Bierings R. Haematologica. 2019 Jan 10. pii: haematol.2018.207787. doi: 10.3324/haematol.2018.207787. PubMed |
| TIPE3 is a regulator of cell apoptosis in glioblastoma. Yuan F, Liu B, Xu Y, Li Y, Sun Q, Xu P, Geng R, Den G, Yang J, Zhang S, Gao L, Liao J, Liu J, Yang X, Tan Y, Chen Q. Cancer Lett. 2019 Apr 1;446:1-14. doi: 10.1016/j.canlet.2018.12.019. Epub 2019 Jan 11. PubMed |
| RNA granules associated with SAMD9-mediated poxvirus restriction are similar to antiviral granules in composition but do not require TIA1 for poxvirus restriction. Meng X, Xiang Y. Virology. 2019 Mar;529:16-22. doi: 10.1016/j.virol.2019.01.007. Epub 2019 Jan 8. PubMed |
| The RNA-Binding Protein PUM2 Impairs Mitochondrial Dynamics and Mitophagy During Aging. D'Amico D, Mottis A, Potenza F, Sorrentino V, Li H, Romani M, Lemos V, Schoonjans K, Zamboni N, Knott G, Schneider BL, Auwerx J. Mol Cell. 2019 Feb 21;73(4):775-787.e10. doi: 10.1016/j.molcel.2018.11.034. Epub 2019 Jan 11. PubMed |
| Increased type III TGF-beta receptor shedding decreases tumorigenesis through induction of epithelial-to-mesenchymal transition. Huang JJ, Corona AL, Dunn BP, Cai EM, Prakken JN, Blobe GC. Oncogene. 2019 May;38(18):3402-3414. doi: 10.1038/s41388-018-0672-7. Epub 2019 Jan 14. PubMed |
GREB1 amplifies androgen receptor output in human prostate cancer and contributes to antiandrogen resistance.
Lee E, Wongvipat J, Choi D, Wang P, Lee YS, Zheng D, Watson PA, Gopalan A, Sawyers CL.
Elife. 2019 Jan 15;8. pii: 41913. doi: 10.7554/eLife.41913.
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| miR-193b represses influenza A virus infection by inhibiting Wnt/beta-catenin signalling. Yang X, Zhao C, Bamunuarachchi G, Wang Y, Liang Y, Huang C, Zhu Z, Xu D, Lin K, Senavirathna LK, Xu L, Liu L. Cell Microbiol. 2019 May;21(5):e13001. doi: 10.1111/cmi.13001. Epub 2019 Jan 25. PubMed |
| Mapping the Human Kinome in Response to DNA Damage. Owusu M, Bannauer P, Ferreira da Silva J, Mourikis TP, Jones A, Majek P, Caldera M, Wiedner M, Lardeau CH, Mueller AC, Menche J, Kubicek S, Ciccarelli FD, Loizou JI. Cell Rep. 2019 Jan 15;26(3):555-563.e6. doi: 10.1016/j.celrep.2018.12.087. PubMed |
| Adenosine Deaminase Acting on RNA 1 Associates with Orf Virus OV20.0 and Enhances Viral Replication. Liao GR, Tseng YY, Tseng CY, Lin FY, Yamada Y, Liu HP, Kuan CY, Hsu WL. J Virol. 2019 Mar 21;93(7). pii: JVI.01912-18. doi: 10.1128/JVI.01912-18. Print 2019 Apr 1. PubMed |
| Clinical resistance to crenolanib in acute myeloid leukemia due to diverse molecular mechanisms. Zhang H, Savage S, Schultz AR, Bottomly D, White L, Segerdell E, Wilmot B, McWeeney SK, Eide CA, Nechiporuk T, Carlos A, Henson R, Lin C, Searles R, Ho H, Lam YL, Sweat R, Follit C, Jain V, Lind E, Borthakur G, Garcia-Manero G, Ravandi F, Kantarjian HM, Cortes J, Collins R, Buelow DR, Baker SD, Druker BJ, Tyner JW. Nat Commun. 2019 Jan 16;10(1):244. doi: 10.1038/s41467-018-08263-x. PubMed |
| TRIM28 promotes HIV-1 latency by SUMOylating CDK9 and inhibiting P-TEFb. Ma X, Yang T, Luo Y, Wu L, Jiang Y, Song Z, Pan T, Liu B, Liu G, Liu J, Yu F, He Z, Zhang W, Yang J, Liang L, Guan Y, Zhang X, Li L, Cai W, Tang X, Gao S, Deng K, Zhang H. Elife. 2019 Jan 17;8. pii: 42426. doi: 10.7554/eLife.42426. PubMed |
| Blockade of a Laminin-411-Notch Axis with CRISPR/Cas9 or a Nanobioconjugate Inhibits Glioblastoma Growth through Tumor-Microenvironment Cross-talk. Sun T, Patil R, Galstyan A, Klymyshyn D, Ding H, Chesnokova A, Cavenee WK, Furnari FB, Ljubimov VA, Shatalova ES, Wagner S, Li D, Mamelak AN, Bannykh SI, Patil CG, Rudnick JD, Hu J, Grodzinski ZB, Rekechenetskiy A, Falahatian V, Lyubimov AV, Chen YL, Leoh LS, Daniels-Wells TR, Penichet ML, Holler E, Ljubimov AV, Black KL, Ljubimova JY. Cancer Res. 2019 Mar 15;79(6):1239-1251. doi: 10.1158/0008-5472.CAN-18-2725. Epub 2019 Jan 18. PubMed |
| Environmental Control of Astrocyte Pathogenic Activities in CNS Inflammation. Wheeler MA, Jaronen M, Covacu R, Zandee SEJ, Scalisi G, Rothhammer V, Tjon EC, Chao CC, Kenison JE, Blain M, Rao VTS, Hewson P, Barroso A, Gutierrez-Vazquez C, Prat A, Antel JP, Hauser R, Quintana FJ. Cell. 2019 Jan 24;176(3):581-596.e18. doi: 10.1016/j.cell.2018.12.012. Epub 2019 Jan 17. PubMed |
| Loss of BCAA Catabolism during Carcinogenesis Enhances mTORC1 Activity and Promotes Tumor Development and Progression. Ericksen RE, Lim SL, McDonnell E, Shuen WH, Vadiveloo M, White PJ, Ding Z, Kwok R, Lee P, Radda GK, Toh HC, Hirschey MD, Han W. Cell Metab. 2019 May 7;29(5):1151-1165.e6. doi: 10.1016/j.cmet.2018.12.020. Epub 2019 Jan 17. PubMed |
| Development of a Bicistronic Vector for the Expression of a CRISPR/Cas9-mCherry System in Fish Cell Lines. Escobar-Aguirre S, Arancibia D, Escorza A, Bravo C, Andres ME, Zamorano P, Martinez V. Cells. 2019 Jan 21;8(1). pii: cells8010075. doi: 10.3390/cells8010075. PubMed |
| HDAC1 and HDAC2 Double Knockout Triggers Cell Apoptosis in Advanced Thyroid Cancer. Lin CL, Tsai ML, Lin CY, Hsu KW, Hsieh WS, Chi WM, Huang LC, Lee CH. Int J Mol Sci. 2019 Jan 21;20(2). pii: ijms20020454. doi: 10.3390/ijms20020454. PubMed |
| Structural and Functional Studies of the RBPJ-SHARP Complex Reveal a Conserved Corepressor Binding Site. Yuan Z, VanderWielen BD, Giaimo BD, Pan L, Collins CE, Turkiewicz A, Hein K, Oswald F, Borggrefe T, Kovall RA. Cell Rep. 2019 Jan 22;26(4):845-854.e6. doi: 10.1016/j.celrep.2018.12.097. PubMed |
| Characterization of a novel species of adenovirus from Japanese microbat and role of CXADR as its entry factor. Kobayashi T, Matsugo H, Maruyama J, Kamiki H, Takada A, Maeda K, Takenaka-Uema A, Tohya Y, Murakami S, Horimoto T. Sci Rep. 2019 Jan 24;9(1):573. doi: 10.1038/s41598-018-37224-z. PubMed |
| beta-Catenin is essential for differentiation of primary myoblasts via cooperation with MyoD and alpha-catenin. Cui S, Li L, Yu RT, Downes M, Evans RM, Hulin JA, Makarenkova HP, Meech R. Development. 2019 Mar 19;146(6). pii: dev.167080. doi: 10.1242/dev.167080. PubMed |
| Role of heparan sulfate in the Zika virus entry, replication, and cell death. Gao H, Lin Y, He J, Zhou S, Liang M, Huang C, Li X, Liu C, Zhang P. Virology. 2019 Mar;529:91-100. doi: 10.1016/j.virol.2019.01.019. Epub 2019 Jan 18. PubMed |
| MAPK4 overexpression promotes tumor progression via noncanonical activation of AKT/mTOR signaling. Wang W, Shen T, Dong B, Creighton CJ, Meng Y, Zhou W, Shi Q, Zhou H, Zhang Y, Moore DD, Yang F. J Clin Invest. 2019 Mar 1;129(3):1015-1029. doi: 10.1172/JCI97712. Epub 2019 Jan 28. PubMed |
| A rapid in vitro methodology for simultaneous target discovery and antibody generation against functional cell subpopulations. Nixon AML, Duque A, Yelle N, McLaughlin M, Davoudi S, Pedley NM, Haynes J, Brown KR, Pan J, Hart T, Gilbert PM, Singh SK, O'Brien CA, Sidhu SS, Moffat J. Sci Rep. 2019 Jan 29;9(1):842. doi: 10.1038/s41598-018-37462-1. PubMed |
| Withaferin A inhibits lysosomal activity to block autophagic flux and induces apoptosis via energetic impairment in breast cancer cells. Muniraj N, Siddharth S, Nagalingam A, Walker A, Woo J, Gyorffy B, Gabrielson E, Saxena NK, Sharma D. Carcinogenesis. 2019 Jan 29. pii: 5303994. doi: 10.1093/carcin/bgz015. PubMed |
| The EF-Hand Protein CALML6 Suppresses Antiviral Innate Immunity by Impairing IRF3 Dimerization. Wang Z, Sheng C, Yao C, Chen H, Wang D, Chen S. Cell Rep. 2019 Jan 29;26(5):1273-1285.e5. doi: 10.1016/j.celrep.2019.01.030. PubMed |
| Design and Assembly of CRISPR/Cas9 Lentiviral and rAAV Vectors for Targeted Genome Editing. Sandoval IM, Collier TJ, Manfredsson FP. Methods Mol Biol. 2019;1937:29-45. doi: 10.1007/978-1-4939-9065-8_2. PubMed |
| Heterotypic CAF-tumor spheroids promote early peritoneal metastatis of ovarian cancer. Gao Q, Yang Z, Xu S, Li X, Yang X, Jin P, Liu Y, Zhou X, Zhang T, Gong C, Wei X, Liu D, Sun C, Chen G, Hu J, Meng L, Zhou J, Sawada K, Fruscio R, Grunt TW, Wischhusen J, Vargas-Hernandez VM, Pothuri B, Coleman RL. J Exp Med. 2019 Mar 4;216(3):688-703. doi: 10.1084/jem.20180765. Epub 2019 Feb 1. PubMed |
| Deficiency of the Fanconi anemia E2 ubiqitin conjugase UBE2T only partially abrogates Alu-mediated recombination in a new model of homology dependent recombination. Lewis TW, Barthelemy JR, Virts EL, Kennedy FM, Gadgil RY, Wiek C, Linka RM, Zhang F, Andreassen PR, Hanenberg H, Leffak M. Nucleic Acids Res. 2019 Apr 23;47(7):3503-3520. doi: 10.1093/nar/gkz026. PubMed |
| Strand break-induced replication fork collapse leads to C-circles, C-overhangs and telomeric recombination. Zhang T, Zhang Z, Shengzhao G, Li X, Liu H, Zhao Y. PLoS Genet. 2019 Feb 4;15(2):e1007925. doi: 10.1371/journal.pgen.1007925. eCollection 2019 Feb. PubMed |
| Magnesium-sensitive upstream ORF controls PRL phosphatase expression to mediate energy metabolism. Hardy S, Kostantin E, Wang SJ, Hristova T, Galicia-Vazquez G, Baranov PV, Pelletier J, Tremblay ML. Proc Natl Acad Sci U S A. 2019 Feb 19;116(8):2925-2934. doi: 10.1073/pnas.1815361116. Epub 2019 Feb 4. PubMed |
| Label-free Quantitative Analysis of Protein Expression Alterations in miR-26a-Knockout HeLa Cells using SWATH-MS Technology. Shen H, Li L, Teng Z, Meng T, Kong X, Hu Y, Zhu Y, Ma L. Sci Rep. 2019 Feb 4;9(1):1399. doi: 10.1038/s41598-018-34904-8. PubMed |
| EZH2 cooperates with gain-of-function p53 mutants to promote cancer growth and metastasis. Zhao Y, Ding L, Wang D, Ye Z, He Y, Ma L, Zhu R, Pan Y, Wu Q, Pang K, Hou X, Weroha SJ, Han C, Coleman R, Coleman I, Karnes RJ, Zhang J, Nelson PS, Wang L, Huang H. EMBO J. 2019 Mar 1;38(5). pii: embj.201899599. doi: 10.15252/embj.201899599. Epub 2019 Feb 5. PubMed |
| Generation of an Oncolytic Herpes Simplex Virus 1 Expressing Human MelanA. Boscheinen JB, Thomann S, Knipe DM, DeLuca N, Schuler-Thurner B, Gross S, Dorrie J, Schaft N, Bach C, Rohrhofer A, Werner-Klein M, Schmidt B, Schuster P. Front Immunol. 2019 Jan 22;10:2. doi: 10.3389/fimmu.2019.00002. eCollection 2019. PubMed |
| Pharmacological reactivation of MYC-dependent apoptosis induces susceptibility to anti-PD-1 immunotherapy. Haikala HM, Anttila JM, Marques E, Raatikainen T, Ilander M, Hakanen H, Ala-Hongisto H, Savelius M, Balboa D, Von Eyss B, Eskelinen V, Munne P, Nieminen AI, Otonkoski T, Schuler J, Laajala TD, Aittokallio T, Sihto H, Mattson J, Heikkila P, Leidenius M, Joensuu H, Mustjoki S, Kovanen P, Eilers M, Leverson JD, Klefstrom J. Nat Commun. 2019 Feb 6;10(1):620. doi: 10.1038/s41467-019-08541-2. PubMed |
| Derepression of LOXL4 inhibits liver cancer growth by reactivating compromised p53. Shao J, Lu J, Zhu W, Yu H, Jing X, Wang YL, Wang X, Wang XJ. Cell Death Differ. 2019 Feb 6. pii: 10.1038/s41418-019-0293-x. doi: 10.1038/s41418-019-0293-x. PubMed |
| L1 drives IFN in senescent cells and promotes age-associated inflammation. De Cecco M, Ito T, Petrashen AP, Elias AE, Skvir NJ, Criscione SW, Caligiana A, Brocculi G, Adney EM, Boeke JD, Le O, Beausejour C, Ambati J, Ambati K, Simon M, Seluanov A, Gorbunova V, Slagboom PE, Helfand SL, Neretti N, Sedivy JM. Nature. 2019 Feb;566(7742):73-78. doi: 10.1038/s41586-018-0784-9. Epub 2019 Feb 6. PubMed |
| Protein kinase Calpha-mediated phosphorylation of Twist1 at Ser-144 prevents Twist1 ubiquitination and stabilizes it. Tedja R, Roberts CM, Alvero AB, Cardenas C, Yang-Hartwich Y, Spadinger S, Pitruzzello M, Yin G, Glackin CA, Mor G. J Biol Chem. 2019 Mar 29;294(13):5082-5093. doi: 10.1074/jbc.RA118.005921. Epub 2019 Feb 7. PubMed |
Evaluation of site-specific homologous recombination activity of BRCA1 by direct quantitation of gene editing efficiency.
Yoshino Y, Endo S, Chen Z, Qi H, Watanabe G, Chiba N.
Sci Rep. 2019 Feb 7;9(1):1644. doi: 10.1038/s41598-018-38311-x.
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| Msx1 loss suppresses formation of the ectopic crypts developed in the Apc-deficient small intestinal epithelium. Horazna M, Janeckova L, Svec J, Babosova O, Hrckulak D, Vojtechova M, Galuskova K, Sloncova E, Kolar M, Strnad H, Korinek V. Sci Rep. 2019 Feb 7;9(1):1629. doi: 10.1038/s41598-018-38310-y. PubMed |
| Genome-Scale CRISPR/Cas9 Screening Reveals Squalene Epoxidase as a Susceptibility Factor for Cytotoxicity of Malformin A1. Koizumi Y, Fukushima J, Kobayashi Y, Kadowaki A, Natsui M, Yamaguchi T, Imai Y, Sugiyama T, Kuba K. Chembiochem. 2019 Jun 14;20(12):1563-1568. doi: 10.1002/cbic.201800769. Epub 2019 Apr 18. PubMed |
| Upregulation of PD-L1 via HMGB1-Activated IRF3 and NF-kappaB Contributes to UV Radiation-Induced Immune Suppression. Wang W, Chapman NM, Zhang B, Li M, Fan M, Laribee RN, Zaidi MR, Pfeffer LM, Chi H, Wu ZH. Cancer Res. 2019 Jun 1;79(11):2909-2922. doi: 10.1158/0008-5472.CAN-18-3134. Epub 2019 Feb 8. PubMed |
| Niclosamide activates the NLRP3 inflammasome by intracellular acidification and mitochondrial inhibition. Thi Tran U, Kitami T. Commun Biol. 2019 Jan 3;2:2. doi: 10.1038/s42003-018-0244-y. eCollection 2019. PubMed |
| SLFN11 can sensitize tumor cells towards IFN-gamma-mediated T cell killing. Mezzadra R, de Bruijn M, Jae LT, Gomez-Eerland R, Duursma A, Scheeren FA, Brummelkamp TR, Schumacher TN. PLoS One. 2019 Feb 12;14(2):e0212053. doi: 10.1371/journal.pone.0212053. eCollection 2019. PubMed |
| Human Cytomegalovirus Immediate Early 86-kDa Protein Blocks Transcription and Induces Degradation of the Immature Interleukin-1beta Protein during Virion-Mediated Activation of the AIM2 Inflammasome. Botto S, Abraham J, Mizuno N, Pryke K, Gall B, Landais I, Streblow DN, Fruh KJ, DeFilippis VR. MBio. 2019 Feb 12;10(1). pii: mBio.02510-18. doi: 10.1128/mBio.02510-18. PubMed |
| STF-62247 accumulates in lysosomes and blocks late stages of autophagy to selectively target von Hippel-Lindau-inactivated cells. Bouhamdani N, Comeau D, Cormier K, Turcotte S. Am J Physiol Cell Physiol. 2019 May 1;316(5):C605-C620. doi: 10.1152/ajpcell.00483.2018. Epub 2019 Feb 13. PubMed |
| A20 Orchestrates Inflammatory Response in the Oral Mucosa through Restraining NF-kappaB Activity. Li Y, Mooney EC, Holden SE, Xia XJ, Cohen DJ, Walsh SW, Ma A, Sahingur SE. J Immunol. 2019 Apr 1;202(7):2044-2056. doi: 10.4049/jimmunol.1801286. Epub 2019 Feb 13. PubMed |
| FcgammaRIIIb Restricts Antibody-Dependent Destruction of Cancer Cells by Human Neutrophils. Treffers LW, van Houdt M, Bruggeman CW, Heineke MH, Zhao XW, van der Heijden J, Nagelkerke SQ, Verkuijlen PJJH, Geissler J, Lissenberg-Thunnissen S, Valerius T, Peipp M, Franke K, van Bruggen R, Kuijpers TW, van Egmond M, Vidarsson G, Matlung HL, van den Berg TK. Front Immunol. 2019 Jan 30;9:3124. doi: 10.3389/fimmu.2018.03124. eCollection 2018. PubMed |
| Novel Chimeric Gene Therapy Vectors Based on Adeno-Associated Virus and Four Different Mammalian Bocaviruses. Fakhiri J, Schneider MA, Puschhof J, Stanifer M, Schildgen V, Holderbach S, Voss Y, El Andari J, Schildgen O, Boulant S, Meister M, Clevers H, Yan Z, Qiu J, Grimm D. Mol Ther Methods Clin Dev. 2019 Jan 18;12:202-222. doi: 10.1016/j.omtm.2019.01.003. eCollection 2019 Mar 15. PubMed |
| O-GlcNAc Transferase Suppresses Inflammation and Necroptosis by Targeting Receptor-Interacting Serine/Threonine-Protein Kinase 3. Li X, Gong W, Wang H, Li T, Attri KS, Lewis RE, Kalil AC, Bhinderwala F, Powers R, Yin G, Herring LE, Asara JM, Lei YL, Yang X, Rodriguez DA, Yang M, Green DR, Singh PK, Wen H. Immunity. 2019 Mar 19;50(3):576-590.e6. doi: 10.1016/j.immuni.2019.01.007. Epub 2019 Feb 12. PubMed |
| In the absence of apoptosis, myeloid cells arrest when deprived of growth factor, but remain viable by consuming extracellular glucose. Dong L, Reljic B, Cheung JG, Ng ES, Lindqvist LM, Elefanty AG, Vaux DL, Tran H. Cell Death Differ. 2019 Oct;26(10):2074-2085. doi: 10.1038/s41418-019-0275-z. Epub 2019 Feb 15. PubMed |
| MiR-135 suppresses glycolysis and promotes pancreatic cancer cell adaptation to metabolic stress by targeting phosphofructokinase-1. Yang Y, Ishak Gabra MB, Hanse EA, Lowman XH, Tran TQ, Li H, Milman N, Liu J, Reid MA, Locasale JW, Gil Z, Kong M. Nat Commun. 2019 Feb 18;10(1):809. doi: 10.1038/s41467-019-08759-0. PubMed |
| Chronic Hypoxia Enhances beta-Oxidation-Dependent Electron Transport via Electron Transferring Flavoproteins. Fuhrmann DC, Olesch C, Kurrle N, Schnutgen F, Zukunft S, Fleming I, Brune B. Cells. 2019 Feb 18;8(2). pii: cells8020172. doi: 10.3390/cells8020172. PubMed |
| Metastasis-associated protein 1 (MTA1) is transferred by exosomes and contributes to the regulation of hypoxia and estrogen signaling in breast cancer cells. Hannafon BN, Gin AL, Xu YF, Bruns M, Calloway CL, Ding WQ. Cell Commun Signal. 2019 Feb 19;17(1):13. doi: 10.1186/s12964-019-0325-7. PubMed |
| Targeted editing of the PSIP1 gene encoding LEDGF/p75 protects cells against HIV infection. Lampi Y, Van Looveren D, Vranckx LS, Thiry I, Bornschein S, Debyser Z, Gijsbers R. Sci Rep. 2019 Feb 20;9(1):2389. doi: 10.1038/s41598-019-38718-0. PubMed |
| Human colon organoids reveal distinct physiologic and oncogenic Wnt responses. Michels BE, Mosa MH, Grebbin BM, Yepes D, Darvishi T, Hausmann J, Urlaub H, Zeuzem S, Kvasnicka HM, Oellerich T, Farin HF. J Exp Med. 2019 Mar 4;216(3):704-720. doi: 10.1084/jem.20180823. Epub 2019 Feb 21. PubMed |
Wnt traffic from endoplasmic reticulum to filopodia.
Moti N, Yu J, Boncompain G, Perez F, Virshup DM.
PLoS One. 2019 Feb 22;14(2):e0212711. doi: 10.1371/journal.pone.0212711. eCollection 2019.
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| An approach for accelerated isolation of genetically manipulated cell clones with reduced clonal variability. Casden N, Behar O. J Cell Sci. 2019 Mar 26;132(6). pii: jcs.217661. doi: 10.1242/jcs.217661. PubMed |
| Dynamic m(6)A mRNA methylation reveals the role of METTL3-m(6)A-CDCP1 signaling axis in chemical carcinogenesis. Yang F, Jin H, Que B, Chao Y, Zhang H, Ying X, Zhou Z, Yuan Z, Su J, Wu B, Zhang W, Qi D, Chen D, Min W, Lin S, Ji W. Oncogene. 2019 Jun;38(24):4755-4772. doi: 10.1038/s41388-019-0755-0. Epub 2019 Feb 22. PubMed |
CRISPR/Cas9-mediated generic protein tagging in mammalian cells.
Thone FMB, Kurrle NS, von Melchner H, Schnutgen F.
Methods. 2019 Jul 15;164-165:59-66. doi: 10.1016/j.ymeth.2019.02.018. Epub 2019 Feb 22.
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| Acetylation Blocks cGAS Activity and Inhibits Self-DNA-Induced Autoimmunity. Dai J, Huang YJ, He X, Zhao M, Wang X, Liu ZS, Xue W, Cai H, Zhan XY, Huang SY, He K, Wang H, Wang N, Sang Z, Li T, Han QY, Mao J, Diao X, Song N, Chen Y, Li WH, Man JH, Li AL, Zhou T, Liu ZG, Zhang XM, Li T. Cell. 2019 Mar 7;176(6):1447-1460.e14. doi: 10.1016/j.cell.2019.01.016. Epub 2019 Feb 21. PubMed |
| Polo-like kinase 4 maintains centriolar satellite integrity by phosphorylation of centrosomal protein 131 (CEP131). Denu RA, Sass MM, Johnson JM, Potts GK, Choudhary A, Coon JJ, Burkard ME. J Biol Chem. 2019 Apr 19;294(16):6531-6549. doi: 10.1074/jbc.RA118.004867. Epub 2019 Feb 25. PubMed |
| The origin of exosomal miR-1246 in human cancer cells. Xu YF, Hannafon BN, Khatri U, Gin A, Ding WQ. RNA Biol. 2019 Jun;16(6):770-784. doi: 10.1080/15476286.2019.1585738. Epub 2019 Mar 23. PubMed |
| Imaging elemental events of store-operated Ca(2+) entry in invading cancer cells with plasmalemmal targeted sensors. Lu F, Sun J, Zheng Q, Li J, Hu Y, Yu P, He H, Zhao Y, Wang X, Yang S, Cheng H. J Cell Sci. 2019 Mar 25;132(6). pii: jcs.224923. doi: 10.1242/jcs.224923. PubMed |
| Functional Profiling Identifies Determinants of Arsenic Trioxide Cellular Toxicity. Sobh A, Loguinov A, Yazici GN, Zeidan RS, Tagmount A, Hejazi NS, Hubbard AE, Zhang L, Vulpe CD. Toxicol Sci. 2019 May 1;169(1):108-121. doi: 10.1093/toxsci/kfz024. PubMed |
| Cross-talk between N-terminal and C-terminal domains in stromal interaction molecule 2 (STIM2) determines enhanced STIM2 sensitivity. Emrich SM, Yoast RE, Xin P, Zhang X, Pathak T, Nwokonko R, Gueguinou MF, Subedi KP, Zhou Y, Ambudkar IS, Hempel N, Machaca K, Gill DL, Trebak M. J Biol Chem. 2019 Apr 19;294(16):6318-6332. doi: 10.1074/jbc.RA118.006801. Epub 2019 Mar 1. PubMed |
| The proinflammatory cytokine TNFalpha induces DNA demethylation-dependent and -independent activation of interleukin-32 expression. Zhao Z, Lan M, Li J, Dong Q, Li X, Liu B, Li G, Wang H, Zhang Z, Zhu B. J Biol Chem. 2019 Apr 26;294(17):6785-6795. doi: 10.1074/jbc.RA118.006255. Epub 2019 Mar 1. PubMed |
| Cyclin D-CDK4 relieves cooperative repression of proliferation and cell cycle gene expression by DREAM and RB. Schade AE, Oser MG, Nicholson HE, DeCaprio JA. Oncogene. 2019 Jun;38(25):4962-4976. doi: 10.1038/s41388-019-0767-9. Epub 2019 Mar 4. PubMed |
| Glutaminyl cyclase is an enzymatic modifier of the CD47- SIRPalpha axis and a target for cancer immunotherapy. Logtenberg MEW, Jansen JHM, Raaben M, Toebes M, Franke K, Brandsma AM, Matlung HL, Fauster A, Gomez-Eerland R, Bakker NAM, van der Schot S, Marijt KA, Verdoes M, Haanen JBAG, van den Berg JH, Neefjes J, van den Berg TK, Brummelkamp TR, Leusen JHW, Scheeren FA, Schumacher TN. Nat Med. 2019 Apr;25(4):612-619. doi: 10.1038/s41591-019-0356-z. Epub 2019 Mar 4. PubMed |
| Phosphorylation at distinct subcellular locations underlies specificity in mTORC2-mediated activation of SGK1 and Akt. Gleason CE, Oses-Prieto JA, Li KH, Saha B, Situ G, Burlingame AL, Pearce D. J Cell Sci. 2019 Apr 9;132(7). pii: jcs.224931. doi: 10.1242/jcs.224931. PubMed |
| Uracil-DNA glycosylase UNG1 isoform variant supports class switch recombination and repairs nuclear genomic uracil. Sarno A, Lundbaek M, Liabakk NB, Aas PA, Mjelle R, Hagen L, Sousa MML, Krokan HE, Kavli B. Nucleic Acids Res. 2019 May 21;47(9):4569-4585. doi: 10.1093/nar/gkz145. PubMed |
| Circular synthesized CRISPR/Cas gRNAs for functional interrogations in the coding and noncoding genome. Wegner M, Diehl V, Bittl V, de Bruyn R, Wiechmann S, Matthess Y, Hebel M, Hayes MG, Schaubeck S, Benner C, Heinz S, Bremm A, Dikic I, Ernst A, Kaulich M. Elife. 2019 Mar 6;8. pii: 42549. doi: 10.7554/eLife.42549. PubMed |
| FMR1 Reactivating Treatments in Fragile X iPSC-Derived Neural Progenitors In Vitro and In Vivo. Vershkov D, Fainstein N, Suissa S, Golan-Lev T, Ben-Hur T, Benvenisty N. Cell Rep. 2019 Mar 5;26(10):2531-2539.e4. doi: 10.1016/j.celrep.2019.02.026. PubMed |
| Human Pluripotent Stem Cell-Derived Tumor Model Uncovers the Embryonic Stem Cell Signature as a Key Driver in Atypical Teratoid/Rhabdoid Tumor. Terada Y, Jo N, Arakawa Y, Sakakura M, Yamada Y, Ukai T, Kabata M, Mitsunaga K, Mineharu Y, Ohta S, Nakagawa M, Miyamoto S, Yamamoto T, Yamada Y. Cell Rep. 2019 Mar 5;26(10):2608-2621.e6. doi: 10.1016/j.celrep.2019.02.009. PubMed |
| MicroRNA-Mediated Suppression of the TGF-beta Pathway Confers Transmissible and Reversible CDK4/6 Inhibitor Resistance. Cornell L, Wander SA, Visal T, Wagle N, Shapiro GI. Cell Rep. 2019 Mar 5;26(10):2667-2680.e7. doi: 10.1016/j.celrep.2019.02.023. PubMed |
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| TZAP plays an inhibitory role in the self-renewal of porcine mesenchymal stromal cells and is implicated the regulation of premature senescence via the p53 pathway. Bie YN, Gu P, Chen YT, Zhou XX, Tian YG, Yang Q, Li HY, Lin X, Guan YH, Lin TY, Lu X, Shen HF, Fang TX, Liu YM, Xiao D, Gu WW. J Transl Med. 2019 Mar 7;17(1):72. doi: 10.1186/s12967-019-1820-8. PubMed |
| Egr1 mediates the effect of insulin on leptin transcription in adipocytes. Mohtar O, Ozdemir C, Roy D, Shantaram D, Emili A, Kandror KV. J Biol Chem. 2019 Apr 12;294(15):5784-5789. doi: 10.1074/jbc.AC119.007855. Epub 2019 Mar 7. PubMed |
| Bcl-2 Is a Therapeutic Target for Hypodiploid B-Lineage Acute Lymphoblastic Leukemia. Diaz-Flores E, Comeaux EQ, Kim KL, Melnik E, Beckman K, Davis KL, Wu K, Akutagawa J, Bridges O, Marino R, Wohlfeil M, Braun BS, Mullighan CG, Loh ML. Cancer Res. 2019 May 1;79(9):2339-2351. doi: 10.1158/0008-5472.CAN-18-0236. Epub 2019 Mar 12. PubMed |
| Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity. Aho ER, Wang J, Gogliotti RD, Howard GC, Phan J, Acharya P, Macdonald JD, Cheng K, Lorey SL, Lu B, Wenzel S, Foshage AM, Alvarado J, Wang F, Shaw JG, Zhao B, Weissmiller AM, Thomas LR, Vakoc CR, Hall MD, Hiebert SW, Liu Q, Stauffer SR, Fesik SW, Tansey WP. Cell Rep. 2019 Mar 12;26(11):2916-2928.e13. doi: 10.1016/j.celrep.2019.02.047. PubMed |
| Single-Cell Heterogeneity Analysis and CRISPR Screen Identify Key beta-Cell-Specific Disease Genes. Fang Z, Weng C, Li H, Tao R, Mai W, Liu X, Lu L, Lai S, Duan Q, Alvarez C, Arvan P, Wynshaw-Boris A, Li Y, Pei Y, Jin F, Li Y. Cell Rep. 2019 Mar 12;26(11):3132-3144.e7. doi: 10.1016/j.celrep.2019.02.043. PubMed |
| TFEB-driven lysosomal biogenesis is pivotal for PGC1alpha-dependent renal stress resistance. Lynch MR, Tran MT, Ralto KM, Zsengeller ZK, Raman V, Bhasin SS, Sun N, Chen X, Brown D, Rovira II, Taguchi K, Brooks CR, Stillman IE, Bhasin MK, Finkel T, Parikh SM. JCI Insight. 2019 Mar 14;5. pii: 126749. doi: 10.1172/jci.insight.126749. PubMed |
| SIGMAR1/Sigma-1 receptor ablation impairs autophagosome clearance. Yang H, Shen H, Li J, Guo LW. Autophagy. 2019 Sep;15(9):1539-1557. doi: 10.1080/15548627.2019.1586248. Epub 2019 Mar 14. PubMed |
| Targeting uPAR by CRISPR/Cas9 System Attenuates Cancer Malignancy and Multidrug Resistance. Wang K, Xing ZH, Jiang QW, Yang Y, Huang JR, Yuan ML, Wei MN, Li Y, Wang ST, Liu K, Shi Z. Front Oncol. 2019 Feb 27;9:80. doi: 10.3389/fonc.2019.00080. eCollection 2019. PubMed |
| EZH2 Inhibition in Ewing Sarcoma Upregulates GD2 Expression for Targeting with Gene-Modified T Cells. Kailayangiri S, Altvater B, Lesch S, Balbach S, Gottlich C, Kuhnemundt J, Mikesch JH, Schelhaas S, Jamitzky S, Meltzer J, Farwick N, Greune L, Fluegge M, Kerl K, Lode HN, Siebert N, Muller I, Walles H, Hartmann W, Rossig C. Mol Ther. 2019 May 8;27(5):933-946. doi: 10.1016/j.ymthe.2019.02.014. Epub 2019 Feb 23. PubMed |
| Optimization of lentiviral transduction parameters and its application for CRISPR-based secretome modification of human endometrial mesenchymal stem cells. Deryabin P, Griukova A, Shatrova A, Petukhov A, Nikolsky N, Borodkina A. Cell Cycle. 2019 Mar - Apr;18(6-7):742-758. doi: 10.1080/15384101.2019.1593650. Epub 2019 Mar 28. PubMed |
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A reference collection of patient-derived cell line and xenograft models of proneural, classical and mesenchymal glioblastoma.
Stringer BW, Day BW, D'Souza RCJ, Jamieson PR, Ensbey KS, Bruce ZC, Lim YC, Goasdoue K, Offenhauser C, Akgul S, Allan S, Robertson T, Lucas P, Tollesson G, Campbell S, Winter C, Do H, Dobrovic A, Inglis PL, Jeffree RL, Johns TG, Boyd AW.
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| A NIK-SIX signalling axis controls inflammation by targeted silencing of non-canonical NF-kappaB. Liu Z, Mar KB, Hanners NW, Perelman SS, Kanchwala M, Xing C, Schoggins JW, Alto NM. Nature. 2019 Apr;568(7751):249-253. doi: 10.1038/s41586-019-1041-6. Epub 2019 Mar 20. PubMed |
| A Systematic Pan-Cancer Analysis of Genetic Heterogeneity Reveals Associations with Epigenetic Modifiers. de Matos MR, Posa I, Carvalho FS, Morais VA, Grosso AR, de Almeida SF. Cancers (Basel). 2019 Mar 20;11(3). pii: cancers11030391. doi: 10.3390/cancers11030391. PubMed |
| Cut-and-Run: A Distinct Mechanism by which V(D)J Recombination Causes Genome Instability. Kirkham CM, Scott JNF, Wang X, Smith AL, Kupinski AP, Ford AM, Westhead DR, Stockley PG, Tuma R, Boyes J. Mol Cell. 2019 May 2;74(3):584-597.e9. doi: 10.1016/j.molcel.2019.02.025. Epub 2019 Mar 21. PubMed |
| Regulation of H2A ubiquitination and SLC7A11 expression by BAP1 and PRC1. Zhang Y, Koppula P, Gan B. Cell Cycle. 2019 Apr;18(8):773-783. doi: 10.1080/15384101.2019.1597506. Epub 2019 Mar 30. PubMed |
| Production and Validation of Lentiviral Vectors for CRISPR/Cas9 Delivery. Ryo LB, Thomsen EA, Mikkelsen JG. Methods Mol Biol. 2019;1961:93-109. doi: 10.1007/978-1-4939-9170-9_7. PubMed |
| Dynamic Dystroglycan Complexes Mediate Cell Entry of Lassa Virus. Herrador A, Fedeli C, Radulovic E, Campbell KP, Moreno H, Gerold G, Kunz S. MBio. 2019 Mar 26;10(2). pii: mBio.02869-18. doi: 10.1128/mBio.02869-18. PubMed |
| Atheroprotective Flow Upregulates ITPR3 (Inositol 1,4,5-Trisphosphate Receptor 3) in Vascular Endothelium via KLF4 (Kruppel-Like Factor 4)-Mediated Histone Modifications. He M, Huang TS, Li S, Hong HC, Chen Z, Martin M, Zhou X, Huang HY, Su SH, Zhang J, Wang WT, Kang J, Huang HD, Zhang J, Chien S, Shyy JY. Arterioscler Thromb Vasc Biol. 2019 May;39(5):902-914. doi: 10.1161/ATVBAHA.118.312301. PubMed |
| Methods to Study the Roles of beta-Arrestins in Meningococcal Signaling. Virion Z, Marullo S, Coureuil M. Methods Mol Biol. 2019;1957:325-334. doi: 10.1007/978-1-4939-9158-7_20. PubMed |
| Up-regulation of FOXD1 by YAP alleviates senescence and osteoarthritis. Fu L, Hu Y, Song M, Liu Z, Zhang W, Yu FX, Wu J, Wang S, Izpisua Belmonte JC, Chan P, Qu J, Tang F, Liu GH. PLoS Biol. 2019 Apr 1;17(4):e3000201. doi: 10.1371/journal.pbio.3000201. eCollection 2019 Apr. PubMed |
| TRPV1 promotes opioid analgesia during inflammation. Basso L, Aboushousha R, Fan CY, Iftinca M, Melo H, Flynn R, Agosti F, Hollenberg MD, Thompson R, Bourinet E, Trang T, Altier C. Sci Signal. 2019 Apr 2;12(575). pii: 12/575/eaav0711. doi: 10.1126/scisignal.aav0711. PubMed |
| Insulin-responsive amino peptidase follows the Glut4 pathway but is dispensable for the formation and translocation of insulin-responsive vesicles. Pan X, Meriin A, Huang G, Kandror KV. Mol Biol Cell. 2019 Jun 1;30(12):1536-1543. doi: 10.1091/mbc.E18-12-0792. Epub 2019 Apr 3. PubMed |
| MERTK mediated novel site Akt phosphorylation alleviates SAV1 suppression. Jiang Y, Zhang Y, Leung JY, Fan C, Popov KI, Su S, Qian J, Wang X, Holtzhausen A, Ubil E, Xiang Y, Davis I, Dokholyan NV, Wu G, Perou CM, Kim WY, Earp HS, Liu P. Nat Commun. 2019 Apr 3;10(1):1515. doi: 10.1038/s41467-019-09233-7. PubMed |
| Genetic dissection of the different roles of hypothalamic kisspeptin neurons in regulating female reproduction. Wang L, Vanacker C, Burger LL, Barnes T, Shah YM, Myers MG, Moenter SM. Elife. 2019 Apr 4;8. pii: 43999. doi: 10.7554/eLife.43999. PubMed |
| Identification of the kinase STK25 as an upstream activator of LATS signaling. Lim S, Hermance N, Mudianto T, Mustaly HM, Mauricio IPM, Vittoria MA, Quinton RJ, Howell BW, Cornils H, Manning AL, Ganem NJ. Nat Commun. 2019 Apr 4;10(1):1547. doi: 10.1038/s41467-019-09597-w. PubMed |
| Systemic clinical tumor regressions and potentiation of PD1 blockade with in situ vaccination. Hammerich L, Marron TU, Upadhyay R, Svensson-Arvelund J, Dhainaut M, Hussein S, Zhan Y, Ostrowski D, Yellin M, Marsh H, Salazar AM, Rahman AH, Brown BD, Merad M, Brody JD. Nat Med. 2019 May;25(5):814-824. doi: 10.1038/s41591-019-0410-x. Epub 2019 Apr 8. PubMed |
Essential Gene Profiles for Human Pluripotent Stem Cells Identify Uncharacterized Genes and Substrate Dependencies.
Mair B, Tomic J, Masud SN, Tonge P, Weiss A, Usaj M, Tong AHY, Kwan JJ, Brown KR, Titus E, Atkins M, Chan KSK, Munsie L, Habsid A, Han H, Kennedy M, Cohen B, Keller G, Moffat J.
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| Rhododendrin-Induced RNF146 Expression via Estrogen Receptor beta Activation is Cytoprotective Against 6-OHDA-Induced Oxidative Stress. Kim H, Park J, Leem H, Cho M, Yoon JH, Maeng HJ, Lee Y. Int J Mol Sci. 2019 Apr 10;20(7). pii: ijms20071772. doi: 10.3390/ijms20071772. PubMed |
| IBTK contributes to B-cell lymphomagenesis in Emu-myc transgenic mice conferring resistance to apoptosis. Vecchio E, Golino G, Pisano A, Albano F, Falcone C, Ceglia S, Iaccino E, Mimmi S, Fiume G, Giurato G, Britti D, Scala G, Quinto I. Cell Death Dis. 2019 Apr 11;10(4):320. doi: 10.1038/s41419-019-1557-6. PubMed |
| LC8/DYNLL1 is a 53BP1 effector and regulates checkpoint activation. West KL, Kelliher JL, Xu Z, An L, Reed MR, Eoff RL, Wang J, Huen MSY, Leung JWC. Nucleic Acids Res. 2019 Jul 9;47(12):6236-6249. doi: 10.1093/nar/gkz263. PubMed |
| Lentiviral Vector Platform for the Efficient Delivery of Epigenome-editing Tools into Human Induced Pluripotent Stem Cell-derived Disease Models. Tagliafierro L, Ilich E, Moncalvo M, Gu J, Sriskanda A, Grenier C, Murphy SK, Chiba-Falek O, Kantor B. J Vis Exp. 2019 Mar 29;(145). doi: 10.3791/59241. PubMed |
| HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries. Luo H, Sobh A, Vulpe CD, Brewer E, Dovat S, Qiu Y, Huang S. J Vis Exp. 2019 Mar 31;(145). doi: 10.3791/59382. PubMed |
| Dual blockage of STAT3 and ERK1/2 eliminates radioresistant GBM cells. Xie B, Zhang L, Hu W, Fan M, Jiang N, Duan Y, Jing D, Xiao W, Fragoso RC, Lam KS, Sun LQ, Li JJ. Redox Biol. 2019 Jun;24:101189. doi: 10.1016/j.redox.2019.101189. Epub 2019 Apr 9. PubMed |
| TP53 Mutation by CRISPR System Enhances the Malignant Potential of Colon Cancer. Watanabe S, Tsuchiya K, Nishimura R, Shirasaki T, Katsukura N, Hibiya S, Okamoto R, Nakamura T, Watanabe M. Mol Cancer Res. 2019 Jul;17(7):1459-1467. doi: 10.1158/1541-7786.MCR-18-1195. Epub 2019 Apr 15. PubMed |
| CRISPR-suppressor scanning reveals a nonenzymatic role of LSD1 in AML. Vinyard ME, Su C, Siegenfeld AP, Waterbury AL, Freedy AM, Gosavi PM, Park Y, Kwan EE, Senzer BD, Doench JG, Bauer DE, Pinello L, Liau BB. Nat Chem Biol. 2019 May;15(5):529-539. doi: 10.1038/s41589-019-0263-0. Epub 2019 Apr 15. PubMed |
| LLGL2 rescues nutrient stress by promoting leucine uptake in ER(+) breast cancer. Saito Y, Li L, Coyaud E, Luna A, Sander C, Raught B, Asara JM, Brown M, Muthuswamy SK. Nature. 2019 May;569(7755):275-279. doi: 10.1038/s41586-019-1126-2. Epub 2019 Apr 17. PubMed |
| Disruption of the MBD2-NuRD complex but not MBD3-NuRD induces high level HbF expression in human erythroid cells. Yu X, Azzo A, Bilinovich SM, Li X, Dozmorov M, Kurita R, Nakamura Y, Williams DC Jr, Ginder GD. Haematologica. 2019 Apr 19. pii: haematol.2018.210963. doi: 10.3324/haematol.2018.210963. PubMed |
Ubiquitin-Dependent and -Independent Roles of E3 Ligase RIPLET in Innate Immunity.
Cadena C, Ahmad S, Xavier A, Willemsen J, Park S, Park JW, Oh SW, Fujita T, Hou F, Binder M, Hur S.
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| Systematic proteomics of endogenous human cohesin reveals an interaction with diverse splicing factors and RNA-binding proteins required for mitotic progression. Kim JS, He X, Liu J, Duan Z, Kim T, Gerard J, Kim B, Pillai MM, Lane WS, Noble WS, Budnik B, Waldman T. J Biol Chem. 2019 May 31;294(22):8760-8772. doi: 10.1074/jbc.RA119.007832. Epub 2019 Apr 22. PubMed |
| PARP Inhibitor Efficacy Depends on CD8(+) T-cell Recruitment via Intratumoral STING Pathway Activation in BRCA-Deficient Models of Triple-Negative Breast Cancer. Pantelidou C, Sonzogni O, De Oliveria Taveira M, Mehta AK, Kothari A, Wang D, Visal T, Li MK, Pinto J, Castrillon JA, Cheney EM, Bouwman P, Jonkers J, Rottenberg S, Guerriero JL, Wulf GM, Shapiro GI. Cancer Discov. 2019 Jun;9(6):722-737. doi: 10.1158/2159-8290.CD-18-1218. Epub 2019 Apr 23. PubMed |
| Centriolar satellites are required for efficient ciliogenesis and ciliary content regulation. Odabasi E, Gul S, Kavakli IH, Firat-Karalar EN. EMBO Rep. 2019 Jun;20(6). pii: embr.201947723. doi: 10.15252/embr.201947723. Epub 2019 Apr 25. PubMed |
| CRISPR Activation Enhances In Vitro Potency of AAV Vectors Driven by Tissue-Specific Promoters. McDougald DS, Duong TT, Palozola KC, Marsh A, Papp TE, Mills JA, Zhou S, Bennett J. Mol Ther Methods Clin Dev. 2019 Mar 28;13:380-389. doi: 10.1016/j.omtm.2019.03.004. eCollection 2019 Jun 14. PubMed |
| Extracellular vesicle release from intestinal organoids is modulated by Apc mutation and other colorectal cancer progression factors. Szvicsek Z, Oszvald A, Szabo L, Sandor GO, Kelemen A, Soos AA, Paloczi K, Harsanyi L, Tolgyes T, Dede K, Bursics A, Buzas EI, Zeold A, Wiener Z. Cell Mol Life Sci. 2019 Jun;76(12):2463-2476. doi: 10.1007/s00018-019-03052-1. Epub 2019 Apr 26. PubMed |
Hypoxia Rescues Frataxin Loss by Restoring Iron Sulfur Cluster Biogenesis.
Ast T, Meisel JD, Patra S, Wang H, Grange RMH, Kim SH, Calvo SE, Orefice LL, Nagashima F, Ichinose F, Zapol WM, Ruvkun G, Barondeau DP, Mootha VK.
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| A calcium/cAMP signaling loop at the ORAI1 mouth drives channel inactivation to shape NFAT induction. Zhang X, Pathak T, Yoast R, Emrich S, Xin P, Nwokonko RM, Johnson M, Wu S, Delierneux C, Gueguinou M, Hempel N, Putney JW Jr, Gill DL, Trebak M. Nat Commun. 2019 Apr 29;10(1):1971. doi: 10.1038/s41467-019-09593-0. PubMed |
| Influence of SHH/GLI1 axis on EMT mediated migration and invasion of breast cancer cells. Riaz SK, Ke Y, Wang F, Kayani MA, Malik MFA. Sci Rep. 2019 Apr 29;9(1):6620. doi: 10.1038/s41598-019-43093-x. PubMed |
| CD13 tethers the IQGAP1-ARF6-EFA6 complex to the plasma membrane to promote ARF6 activation, beta1 integrin recycling, and cell migration. Ghosh M, Lo R, Ivic I, Aguilera B, Qendro V, Devarakonda C, Shapiro LH. Sci Signal. 2019 Apr 30;12(579). pii: 12/579/eaav5938. doi: 10.1126/scisignal.aav5938. PubMed |
| Molecular dissection of box jellyfish venom cytotoxicity highlights an effective venom antidote. Lau MT, Manion J, Littleboy JB, Oyston L, Khuong TM, Wang QP, Nguyen DT, Hesselson D, Seymour JE, Neely GG. Nat Commun. 2019 Apr 30;10(1):1655. doi: 10.1038/s41467-019-09681-1. PubMed |
| Oncogenic ERBB2 Aberrations and KRAS Mutations Cooperate to Promote Pancreatic Ductal Adenocarcinoma Progression. Li Z, Shao C, Liu X, Lu X, Jia X, Zheng X, Wang S, Zhu L, Li K, Pang Y, Xie F, Lu Y, Wang Y. Carcinogenesis. 2019 May 2. pii: 5484775. doi: 10.1093/carcin/bgz086. PubMed |
| Parity predisposes breasts to the oncogenic action of PAPP-A and activation of the collagen receptor DDR2. Slocum E, Craig A, Villanueva A, Germain D. Breast Cancer Res. 2019 May 2;21(1):56. doi: 10.1186/s13058-019-1142-z. PubMed |
| Ca(2+)-Stimulated AMPK-Dependent Phosphorylation of Exo1 Protects Stressed Replication Forks from Aberrant Resection. Li S, Lavagnino Z, Lemacon D, Kong L, Ustione A, Ng X, Zhang Y, Wang Y, Zheng B, Piwnica-Worms H, Vindigni A, Piston DW, You Z. Mol Cell. 2019 Jun 20;74(6):1123-1137.e6. doi: 10.1016/j.molcel.2019.04.003. Epub 2019 Apr 30. PubMed |
| STX17 dynamically regulated by Fis1 induces mitophagy via hierarchical macroautophagic mechanism. Xian H, Yang Q, Xiao L, Shen HM, Liou YC. Nat Commun. 2019 May 3;10(1):2059. doi: 10.1038/s41467-019-10096-1. PubMed |
| Genome-Wide CRISPR Screening Identifies the Tumor Suppressor Candidate OVCA2 As a Determinant of Tolerance to Acetaldehyde. Sobh A, Loguinov A, Stornetta A, Balbo S, Tagmount A, Zhang L, Vulpe CD. Toxicol Sci. 2019 May 1;169(1):235-245. doi: 10.1093/toxsci/kfz037. PubMed |
| The transcription factor CBFB suppresses breast cancer through orchestrating translation and transcription. Malik N, Yan H, Moshkovich N, Palangat M, Yang H, Sanchez V, Cai Z, Peat TJ, Jiang S, Liu C, Lee M, Mock BA, Yuspa SH, Larson D, Wakefield LM, Huang J. Nat Commun. 2019 May 6;10(1):2071. doi: 10.1038/s41467-019-10102-6. PubMed |
| SpCas9-expression by tumor cells can cause T cell-dependent tumor rejection in immunocompetent mice. Ajina R, Zamalin D, Zuo A, Moussa M, Catalfamo M, Jablonski SA, Weiner LM. Oncoimmunology. 2019 Mar 16;8(5):e1577127. doi: 10.1080/2162402X.2019.1577127. eCollection 2019. PubMed |
| HDAC1,2 Knock-Out and HDACi Induced Cell Apoptosis in Imatinib-Resistant K562 Cells. Chen SH, Chow JM, Hsieh YY, Lin CY, Hsu KW, Hsieh WS, Chi WM, Shabangu BM, Lee CH. Int J Mol Sci. 2019 May 8;20(9). pii: ijms20092271. doi: 10.3390/ijms20092271. PubMed |
| Identification of Cancer Drivers at CTCF Insulators in 1,962 Whole Genomes. Liu EM, Martinez-Fundichely A, Diaz BJ, Aronson B, Cuykendall T, MacKay M, Dhingra P, Wong EWP, Chi P, Apostolou E, Sanjana NE, Khurana E. Cell Syst. 2019 May 22;8(5):446-455.e8. doi: 10.1016/j.cels.2019.04.001. Epub 2019 May 8. PubMed |
| A CRISPR/Cas9 Whole-Genome Screen Identifies Genes Required for Aryl Hydrocarbon Receptor-Dependent Induction of Functional CYP1A1. Sundberg CD, Hankinson O. Toxicol Sci. 2019 Aug 1;170(2):310-319. doi: 10.1093/toxsci/kfz111. PubMed |
| Genetic and Functional Dissection of the Role of Individual 5-HT2 Receptors as Entry Receptors for JC Polyomavirus. Assetta B, Morris-Love J, Gee GV, Atkinson AL, O'Hara BA, Maginnis MS, Haley SA, Atwood WJ. Cell Rep. 2019 May 14;27(7):1960-1966.e6. doi: 10.1016/j.celrep.2019.04.067. PubMed |
| The PHLPP2 phosphatase is a druggable driver of prostate cancer progression. Nowak DG, Katsenelson KC, Watrud KE, Chen M, Mathew G, D'Andrea VD, Lee MF, Swamynathan MM, Casanova-Salas I, Jibilian MC, Buckholtz CL, Ambrico AJ, Pan CH, Wilkinson JE, Newton AC, Trotman LC. J Cell Biol. 2019 Jun 3;218(6):1943-1957. doi: 10.1083/jcb.201902048. Epub 2019 May 15. PubMed |
| TIM1 (HAVCR1): an Essential "Receptor" or an "Accessory Attachment Factor" for Hepatitis A Virus? Das A, Maury W, Lemon SM. J Virol. 2019 May 15;93(11). pii: 93/11/e01793-18. doi: 10.1128/JVI.01793-18. Print 2019 Jun 1. PubMed |
| Generation of a Jurkat-based fluorescent reporter cell line to evaluate lipid antigen interaction with the human iNKT cell receptor. Humeniuk P, Geiselhart S, Battin C, Webb T, Steinberger P, Paster W, Hoffmann-Sommergrsuber K. Sci Rep. 2019 May 15;9(1):7426. doi: 10.1038/s41598-019-43529-4. PubMed |
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Depletion of TRRAP induces p53-independent senescence in liver cancer by downregulating mitotic genes.
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Transient Receptor Potential V Channels Are Essential for Glucose Sensing by Aldolase and AMPK.
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| The role of ZAP and OAS3/RNAseL pathways in the attenuation of an RNA virus with elevated frequencies of CpG and UpA dinucleotides. Odon V, Fros JJ, Goonawardane N, Dietrich I, Ibrahim A, Alshaikhahmed K, Nguyen D, Simmonds P. Nucleic Acids Res. 2019 Jul 5. pii: 5528741. doi: 10.1093/nar/gkz581. PubMed |
| Inactive Cas9 blocks vitreous-induced expression of Mdm2 and proliferation and survival of retinal pigment epithelial cells. Chen N, Hu Z, Yang Y, Han H, Lei H. Exp Eye Res. 2019 Jul 3;186:107716. doi: 10.1016/j.exer.2019.107716. PubMed |
| PCIF1 Catalyzes m6Am mRNA Methylation to Regulate Gene Expression. Sendinc E, Valle-Garcia D, Dhall A, Chen H, Henriques T, Navarrete-Perea J, Sheng W, Gygi SP, Adelman K, Shi Y. Mol Cell. 2019 Jun 18. pii: S1097-2765(19)30402-2. doi: 10.1016/j.molcel.2019.05.030. PubMed |
| Generation of a FMR1 homozygous knockout human embryonic stem cell line (WAe009-A-16) by CRISPR/Cas9 editing. Giri S, Purushottam M, Viswanath B, Muddashetty RS. Stem Cell Res. 2019 Jun 28;39:101494. doi: 10.1016/j.scr.2019.101494. PubMed |
| Conserved Herpesvirus Protein Kinases Target SAMHD1 to Facilitate Virus Replication. Zhang K, Lv DW, Li R. Cell Rep. 2019 Jul 9;28(2):449-459.e5. doi: 10.1016/j.celrep.2019.04.020. PubMed |
| Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium. Pentinmikko N, Iqbal S, Mana M, Andersson S, Cognetta AB 3rd, Suciu RM, Roper J, Luopajarvi K, Markelin E, Gopalakrishnan S, Smolander OP, Naranjo S, Saarinen T, Juuti A, Pietilainen K, Auvinen P, Ristimaki A, Gupta N, Tammela T, Jacks T, Sabatini DM, Cravatt BF, Yilmaz OH, Katajisto P. Nature. 2019 Jul;571(7765):398-402. doi: 10.1038/s41586-019-1383-0. Epub 2019 Jul 10. PubMed |
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| Sporadic and endemic Burkitt lymphoma have frequent FOXO1 mutations but distinct hotspots in the AKT recognition motif. Zhou P, Blain AE, Newman AM, Zaka M, Chagaluka G, Adlar FR, Offor UT, Broadbent C, Chaytor L, Whitehead A, Hall A, O'Connor H, Van Noorden S, Lampert I, Bailey S, Molyneux E, Bacon CM, Bomken S, Rand V. Blood Adv. 2019 Jul 23;3(14):2118-2127. doi: 10.1182/bloodadvances.2018029546. PubMed |
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Engineering Forward Genetics into Cultured Cancer Cells for Chemical Target Identification.
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| A real-time, click chemistry imaging approach reveals stimulus-specific subcellular locations of phospholipase D activity. Liang D, Wu K, Tei R, Bumpus TW, Ye J, Baskin JM. Proc Natl Acad Sci U S A. 2019 Jul 30;116(31):15453-15462. doi: 10.1073/pnas.1903949116. Epub 2019 Jul 16. PubMed |
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| Copper chaperone ATOX1 is required for MAPK signaling and growth in BRAF mutation-positive melanoma. Kim YJ, Bond GJ, Tsang T, Posimo JM, Busino L, Brady DC. Metallomics. 2019 Aug 1;11(8):1430-1440. doi: 10.1039/c9mt00042a. Epub 2019 Jul 18. PubMed |
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| The transporters SLC35A1 and SLC30A1 play opposite roles in cell survival upon VSV virus infection. Moskovskich A, Goldmann U, Kartnig F, Lindinger S, Konecka J, Fiume G, Girardi E, Superti-Furga G. Sci Rep. 2019 Jul 18;9(1):10471. doi: 10.1038/s41598-019-46952-9. PubMed |
| Differential Signaling Mediated by ApoE2, ApoE3, and ApoE4 in Human Neurons Parallels Alzheimer's Disease Risk. Huang YA, Zhou B, Nabet AM, Wernig M, Sudhof TC. J Neurosci. 2019 Sep 11;39(37):7408-7427. doi: 10.1523/JNEUROSCI.2994-18.2019. Epub 2019 Jul 22. PubMed |
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| Charge-Mediated Pyrin Oligomerization Nucleates Antiviral IFI16 Sensing of Herpesvirus DNA. Lum KK, Howard TR, Pan C, Cristea IM. mBio. 2019 Jul 23;10(4). pii: mBio.01428-19. doi: 10.1128/mBio.01428-19. PubMed |
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| Human Artificial Chromosomes that Bypass Centromeric DNA. Logsdon GA, Gambogi CW, Liskovykh MA, Barrey EJ, Larionov V, Miga KH, Heun P, Black BE. Cell. 2019 Jul 25;178(3):624-639.e19. doi: 10.1016/j.cell.2019.06.006. PubMed |
The AMPK-Related Kinases SIK1 and SIK3 Mediate Key Tumor-Suppressive Effects of LKB1 in NSCLC.
Hollstein PE, Eichner LJ, Brun SN, Kamireddy A, Svensson RU, Vera LI, Ross DS, Rymoff TJ, Hutchins A, Galvez HM, Williams AE, Shokhirev MN, Screaton RA, Berdeaux R, Shaw RJ.
Cancer Discov. 2019 Nov;9(11):1606-1627. doi: 10.1158/2159-8290.CD-18-1261. Epub 2019 Jul 26.
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| Stabilizing heterochromatin by DGCR8 alleviates senescence and osteoarthritis. Deng L, Ren R, Liu Z, Song M, Li J, Wu Z, Ren X, Fu L, Li W, Zhang W, Guillen P, Izpisua Belmonte JC, Chan P, Qu J, Liu GH. Nat Commun. 2019 Jul 26;10(1):3329. doi: 10.1038/s41467-019-10831-8. PubMed |
| AAGAB Controls AP2 Adaptor Assembly in Clathrin-Mediated Endocytosis. Gulbranson DR, Crisman L, Lee M, Ouyang Y, Menasche BL, Demmitt BA, Wan C, Nomura T, Ye Y, Yu H, Shen J. Dev Cell. 2019 Aug 19;50(4):436-446.e5. doi: 10.1016/j.devcel.2019.06.013. Epub 2019 Jul 25. PubMed |
| TREM1/3 Deficiency Impairs Tissue Repair After Acute Kidney Injury and Mitochondrial Metabolic Flexibility in Tubular Epithelial Cells. Tammaro A, Scantlebery AML, Rampanelli E, Borrelli C, Claessen N, Butter LM, Soriani A, Colonna M, Leemans JC, Dessing MC, Florquin S. Front Immunol. 2019 Jul 9;10:1469. doi: 10.3389/fimmu.2019.01469. eCollection 2019. PubMed |
| TSPAN12 Precedes Tumor Proliferation by Cell Cycle Control in Ovarian Cancer. Ji G, Liang H, Wang F, Wang N, Fu S, Cui X. Mol Cells. 2019 Jul 31;42(7):557-567. doi: 10.14348/molcells.2019.0015. PubMed |
| A principled strategy for mapping enhancers to genes. Kim D, An H, Shearer RS, Sharif M, Fan C, Choi JO, Ryu S, Park Y. Sci Rep. 2019 Jul 30;9(1):11043. doi: 10.1038/s41598-019-47521-w. PubMed |
| Loss of p53 triggers WNT-dependent systemic inflammation to drive breast cancer metastasis. Wellenstein MD, Coffelt SB, Duits DEM, van Miltenburg MH, Slagter M, de Rink I, Henneman L, Kas SM, Prekovic S, Hau CS, Vrijland K, Drenth AP, de Korte-Grimmerink R, Schut E, van der Heijden I, Zwart W, Wessels LFA, Schumacher TN, Jonkers J, de Visser KE. Nature. 2019 Aug;572(7770):538-542. doi: 10.1038/s41586-019-1450-6. Epub 2019 Jul 31. PubMed |
| A CRISPR-Cas9 screen identifies essential CTCF anchor sites for estrogen receptor-driven breast cancer cell proliferation. Korkmaz G, Manber Z, Lopes R, Prekovic S, Schuurman K, Kim Y, Teunissen H, Flach K, Wit E, Galli GG, Zwart W, Elkon R, Agami R. Nucleic Acids Res. 2019 Oct 10;47(18):9557-9572. doi: 10.1093/nar/gkz675. PubMed |
| Modeling Monogenic Diabetes using Human ESCs Reveals Developmental and Metabolic Deficiencies Caused by Mutations in HNF1A. Cardenas-Diaz FL, Osorio-Quintero C, Diaz-Miranda MA, Kishore S, Leavens K, Jobaliya C, Stanescu D, Ortiz-Gonzalez X, Yoon C, Chen CS, Haliyur R, Brissova M, Powers AC, French DL, Gadue P. Cell Stem Cell. 2019 Aug 1;25(2):273-289.e5. doi: 10.1016/j.stem.2019.07.007. PubMed |
| Targeted inhibition of CD47-SIRPalpha requires Fc-FcgammaR interactions to maximize activity in T-cell lymphomas. Jain S, Van Scoyk A, Morgan EA, Matthews A, Stevenson K, Newton G, Powers F, Autio A, Louissaint A, Pontini G, Aster JC, Luscinskas FW, Weinstock DM. Blood. 2019 Oct 24;134(17):1430-1440. doi: 10.1182/blood.2019001744. PubMed |
| Ring finger protein 121 is a potent regulator of adeno-associated viral genome transcription. Madigan VJ, Yuziuk JA, Chiarella AM, Tyson TO, Meganck RM, Elmore ZC, Tse LV, Hathaway NA, Asokan A. PLoS Pathog. 2019 Aug 6;15(8):e1007988. doi: 10.1371/journal.ppat.1007988. eCollection 2019 Aug. PubMed |
| Inhibition of the ULK1 protein complex suppresses Staphylococcus-induced autophagy and cell death. Radhi OA, Davidson S, Scott F, Zeng RX, Jones DH, Tomkinson NCO, Yu J, Chan EYW. J Biol Chem. 2019 Sep 27;294(39):14289-14307. doi: 10.1074/jbc.RA119.008923. Epub 2019 Aug 6. PubMed |
| A CRISPR Screen Identifies the Cell Polarity Determinant Crumbs 3 as an Adeno-associated Virus Restriction Factor in Hepatocytes. Madigan VJ, Tyson TO, Yuziuk JA, Pillai M, Moller-Tank S, Asokan A. J Virol. 2019 Oct 15;93(21). pii: JVI.00943-19. doi: 10.1128/JVI.00943-19. Print 2019 Nov 1. PubMed |
| SAMHD1 Regulates Human Papillomavirus 16-Induced Cell Proliferation and Viral Replication during Differentiation of Keratinocytes. James CD, Prabhakar AT, Otoa R, Evans MR, Wang X, Bristol ML, Zhang K, Li R, Morgan IM. mSphere. 2019 Aug 7;4(4). pii: 4/4/e00448-19. doi: 10.1128/mSphere.00448-19. PubMed |
| An influenza virus-triggered SUMO switch orchestrates co-opted endogenous retroviruses to stimulate host antiviral immunity. Schmidt N, Domingues P, Golebiowski F, Patzina C, Tatham MH, Hay RT, Hale BG. Proc Natl Acad Sci U S A. 2019 Aug 27;116(35):17399-17408. doi: 10.1073/pnas.1907031116. Epub 2019 Aug 7. PubMed |
| T-Scan: A Genome-wide Method for the Systematic Discovery of T Cell Epitopes. Kula T, Dezfulian MH, Wang CI, Abdelfattah NS, Hartman ZC, Wucherpfennig KW, Lyerly HK, Elledge SJ. Cell. 2019 Aug 8;178(4):1016-1028.e13. doi: 10.1016/j.cell.2019.07.009. PubMed |
The Oncogenic Action of NRF2 Depends on De-glycation by Fructosamine-3-Kinase.
Sanghvi VR, Leibold J, Mina M, Mohan P, Berishaj M, Li Z, Miele MM, Lailler N, Zhao C, de Stanchina E, Viale A, Akkari L, Lowe SW, Ciriello G, Hendrickson RC, Wendel HG.
Cell. 2019 Aug 8;178(4):807-819.e21. doi: 10.1016/j.cell.2019.07.031.
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| Exosomal PD-L1 promotes tumor growth through immune escape in non-small cell lung cancer. Kim DH, Kim H, Choi YJ, Kim SY, Lee JE, Sung KJ, Sung YH, Pack CG, Jung MK, Han B, Kim K, Kim WS, Nam SJ, Choi CM, Yun M, Lee JC, Rho JK. Exp Mol Med. 2019 Aug 9;51(8):94. doi: 10.1038/s12276-019-0295-2. PubMed |
| RAD51AP1 Is an Essential Mediator of Alternative Lengthening of Telomeres. Barroso-Gonzalez J, Garcia-Exposito L, Hoang SM, Lynskey ML, Roncaioli JL, Ghosh A, Wallace CT, Modesti M, Bernstein KA, Sarkar SN, Watkins SC, O'Sullivan RJ. Mol Cell. 2019 Oct 3;76(1):11-26.e7. doi: 10.1016/j.molcel.2019.06.043. Epub 2019 Aug 7. PubMed |
Multiplexed genome engineering by Cas12a and CRISPR arrays encoded on single transcripts.
Campa CC, Weisbach NR, Santinha AJ, Incarnato D, Platt RJ.
Nat Methods. 2019 Aug 12. pii: 10.1038/s41592-019-0508-6. doi: 10.1038/s41592-019-0508-6.
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| Therapeutic Targeting of RNA Splicing Catalysis through Inhibition of Protein Arginine Methylation. Fong JY, Pignata L, Goy PA, Kawabata KC, Lee SC, Koh CM, Musiani D, Massignani E, Kotini AG, Penson A, Wun CM, Shen Y, Schwarz M, Low DH, Rialdi A, Ki M, Wollmann H, Mzoughi S, Gay F, Thompson C, Hart T, Barbash O, Luciani GM, Szewczyk MM, Wouters BJ, Delwel R, Papapetrou EP, Barsyte-Lovejoy D, Arrowsmith CH, Minden MD, Jin J, Melnick A, Bonaldi T, Abdel-Wahab O, Guccione E. Cancer Cell. 2019 Aug 12;36(2):194-209.e9. doi: 10.1016/j.ccell.2019.07.003. PubMed |
| The isothiocyanate sulforaphane inhibits mTOR in an NRF2-independent manner. Zhang Y, Gilmour A, Ahn YH, de la Vega L, Dinkova-Kostova AT. Phytomedicine. 2019 Aug 5:153062. doi: 10.1016/j.phymed.2019.153062. PubMed |
| Epitranscriptomic Addition of m(5)C to HIV-1 Transcripts Regulates Viral Gene Expression. Courtney DG, Tsai K, Bogerd HP, Kennedy EM, Law BA, Emery A, Swanstrom R, Holley CL, Cullen BR. Cell Host Microbe. 2019 Aug 14;26(2):217-227.e6. doi: 10.1016/j.chom.2019.07.005. PubMed |
| The synthesis of branched-chain fatty acids is limited by enzymatic decarboxylation of ethyl- and methylmalonyl-CoA. Dewulf JP, Gerin I, Rider MH, Veiga-da-Cunha M, Van Schaftingen E, Bommer GT. Biochem J. 2019 Aug 30;476(16):2427-2447. doi: 10.1042/BCJ20190500. PubMed |
| Interplay between c-Src and the APC/C co-activator Cdh1 regulates mammary tumorigenesis. Han T, Jiang S, Zheng H, Yin Q, Xie M, Little MR, Yin X, Chen M, Song SJ, Beg AA, Pandolfi PP, Wan L. Nat Commun. 2019 Aug 16;10(1):3716. doi: 10.1038/s41467-019-11618-7. PubMed |
| Cytoplasmic DAXX drives SQSTM1/p62 phase condensation to activate Nrf2-mediated stress response. Yang Y, Willis TL, Button RW, Strang CJ, Fu Y, Wen X, Grayson PRC, Evans T, Sipthorpe RJ, Roberts SL, Hu B, Zhang J, Lu B, Luo S. Nat Commun. 2019 Aug 21;10(1):3759. doi: 10.1038/s41467-019-11671-2. PubMed |
| Identification of an ATP-sensitive potassium channel in mitochondria. Paggio A, Checchetto V, Campo A, Menabo R, Di Marco G, Di Lisa F, Szabo I, Rizzuto R, De Stefani D. Nature. 2019 Aug;572(7771):609-613. doi: 10.1038/s41586-019-1498-3. Epub 2019 Aug 21. PubMed |
| Blockade of MDM2 with inactive Cas9 prevents epithelial to mesenchymal transition in retinal pigment epithelial cells. Liu B, Song J, Han H, Hu Z, Chen N, Cui J, Matsubara JA, Zhong J, Lei H. Lab Invest. 2019 Dec;99(12):1874-1886. doi: 10.1038/s41374-019-0307-9. Epub 2019 Aug 22. PubMed |
| A Yap-Myc-Sox2-p53 Regulatory Network Dictates Metabolic Homeostasis and Differentiation in Kras-Driven Pancreatic Ductal Adenocarcinomas. Murakami S, Nemazanyy I, White SM, Chen H, Nguyen CDK, Graham GT, Saur D, Pende M, Yi C. Dev Cell. 2019 Oct 7;51(1):113-128.e9. doi: 10.1016/j.devcel.2019.07.022. Epub 2019 Aug 22. PubMed |
| SLX4IP Antagonizes Promiscuous BLM Activity during ALT Maintenance. Panier S, Maric M, Hewitt G, Mason-Osann E, Gali H, Dai A, Labadorf A, Guervilly JH, Ruis P, Segura-Bayona S, Belan O, Marzec P, Gaillard PHL, Flynn RL, Boulton SJ. Mol Cell. 2019 Oct 3;76(1):27-43.e11. doi: 10.1016/j.molcel.2019.07.010. Epub 2019 Aug 22. PubMed |
| Toxoplasma gondii activates a Syk-CARD9-NF-kappaB signaling axis and gasdermin D-independent release of IL-1beta during infection of primary human monocytes. Pandori WJ, Lima TS, Mallya S, Kao TH, Gov L, Lodoen MB. PLoS Pathog. 2019 Aug 26;15(8):e1007923. doi: 10.1371/journal.ppat.1007923. eCollection 2019 Aug. PubMed |
| Identification of novel TGF-beta regulated genes with pro-migratory roles. Liu Q, Borcherding N, Shao P, Cao H, Zhang W, Qi HH. Biochim Biophys Acta Mol Basis Dis. 2019 Dec 1;1865(12):165537. doi: 10.1016/j.bbadis.2019.165537. Epub 2019 Aug 23. PubMed |
| Increased expression of heme-binding protein 1 early in Alzheimer's disease is linked to neurotoxicity. Yagensky O, Kohansal-Nodehi M, Gunaseelan S, Rabe T, Zafar S, Zerr I, Hartig W, Urlaub H, Chua JJ. Elife. 2019 Aug 27;8. pii: 47498. doi: 10.7554/eLife.47498. PubMed |
| BMI1 is directly regulated by androgen receptor to promote castration-resistance in prostate cancer. Zhu S, Zhao D, Li C, Li Q, Jiang W, Liu Q, Wang R, Fazli L, Li Y, Zhang L, Yi Y, Meng Q, Wang W, Wang G, Zhang M, Zu X, Zhao W, Deng T, Yu J, Dong X, Chen K, Cao Q. Oncogene. 2020 Jan;39(1):17-29. doi: 10.1038/s41388-019-0966-4. Epub 2019 Aug 28. PubMed |
| Phosphoinositide 3-kinase delta inactivation prevents vitreous-induced activation of AKT/MDM2/p53 and migration of retinal pigment epithelial cells. Han H, Chen N, Huang X, Liu B, Tian J, Lei H. J Biol Chem. 2019 Oct 18;294(42):15408-15417. doi: 10.1074/jbc.RA119.010130. Epub 2019 Aug 29. PubMed |
Control of homologous recombination by the HROB-MCM8-MCM9 pathway.
Hustedt N, Saito Y, Zimmermann M, Alvarez-Quilon A, Setiaputra D, Adam S, McEwan A, Yuan JY, Olivieri M, Zhao Y, Kanemaki MT, Jurisicova A, Durocher D.
Genes Dev. 2019 Oct 1;33(19-20):1397-1415. doi: 10.1101/gad.329508.119. Epub 2019 Aug 29.
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| Long non-coding RNA PXN-AS1 suppresses pancreatic cancer progression by acting as a competing endogenous RNA of miR-3064 to upregulate PIP4K2B expression. Yan J, Jia Y, Chen H, Chen W, Zhou X. J Exp Clin Cancer Res. 2019 Sep 5;38(1):390. doi: 10.1186/s13046-019-1379-5. PubMed |
| Newly identified LMO3-BORCS5 fusion oncogene in Ewing sarcoma at relapse is a driver of tumor progression. Dupain C, Gracia C, Harttrampf AC, Riviere J, Geoerger B, Massaad-Massade L. Oncogene. 2019 Nov;38(47):7200-7215. doi: 10.1038/s41388-019-0914-3. Epub 2019 Sep 5. PubMed |
| mTORC1 Activation Requires DRAM-1 by Facilitating Lysosomal Amino Acid Efflux. Beaumatin F, O'Prey J, Barthet VJA, Zunino B, Parvy JP, Bachmann AM, O'Prey M, Kania E, Gonzalez PS, Macintosh R, Lao LY, Nixon C, Lopez J, Long JS, Tait SWG, Ryan KM. Mol Cell. 2019 Oct 3;76(1):163-176.e8. doi: 10.1016/j.molcel.2019.07.021. Epub 2019 Sep 3. PubMed |
| SOX11 and SOX4 drive the reactivation of an embryonic gene program during murine wound repair. Miao Q, Hill MC, Chen F, Mo Q, Ku AT, Ramos C, Sock E, Lefebvre V, Nguyen H. Nat Commun. 2019 Sep 6;10(1):4042. doi: 10.1038/s41467-019-11880-9. PubMed |
| SliceIt: A genome-wide resource and visualization tool to design CRISPR/Cas9 screens for editing protein-RNA interaction sites in the human genome. Vemuri S, Srivastava R, Mir Q, Hashemikhabir S, Dong XC, Janga SC. Methods. 2020 Jun 1;178:104-113. doi: 10.1016/j.ymeth.2019.09.004. Epub 2019 Sep 5. PubMed |
| Generation of Knockout Human Primary Keratinocytes by CRISPR/Cas9. Grossi S, Fenini G, Hennig P, Di Filippo M, Beer HD. Methods Mol Biol. 2019 Sep 10. doi: 10.1007/7651_2019_262. PubMed |
| A consensus set of genetic vulnerabilities to ATR inhibition. Hustedt N, Alvarez-Quilon A, McEwan A, Yuan JY, Cho T, Koob L, Hart T, Durocher D. Open Biol. 2019 Sep 27;9(9):190156. doi: 10.1098/rsob.190156. Epub 2019 Sep 11. PubMed |
| Molecular mechanism for the multiple sclerosis risk variant rs17594362. Kim D, Park Y. Hum Mol Genet. 2019 Nov 1;28(21):3600-3609. doi: 10.1093/hmg/ddz216. PubMed |
| Fascin Controls Metastatic Colonization and Mitochondrial Oxidative Phosphorylation by Remodeling Mitochondrial Actin Filaments. Lin S, Huang C, Gunda V, Sun J, Chellappan SP, Li Z, Izumi V, Fang B, Koomen J, Singh PK, Hao J, Yang S. Cell Rep. 2019 Sep 10;28(11):2824-2836.e8. doi: 10.1016/j.celrep.2019.08.011. PubMed |
| Cannabidiol induces antioxidant pathways in keratinocytes by targeting BACH1. Casares L, Garcia V, Garrido-Rodriguez M, Millan E, Collado JA, Garcia-Martin A, Penarando J, Calzado MA, de la Vega L, Munoz E. Redox Biol. 2020 Jan;28:101321. doi: 10.1016/j.redox.2019.101321. Epub 2019 Sep 5. PubMed |
| Genomic tagging of endogenous human ESCRT-I complex preserves ESCRT-mediated membrane-remodeling functions. Hoffman HK, Fernandez MV, Groves NS, Freed EO, van Engelenburg SB. J Biol Chem. 2019 Nov 1;294(44):16266-16281. doi: 10.1074/jbc.RA119.009372. Epub 2019 Sep 13. PubMed |
| SLC1A3 contributes to L-asparaginase resistance in solid tumors. Sun J, Nagel R, Zaal EA, Ugalde AP, Han R, Proost N, Song JY, Pataskar A, Burylo A, Fu H, Poelarends GJ, van de Ven M, van Tellingen O, Berkers CR, Agami R. EMBO J. 2019 Oct 4;38(21):e102147. doi: 10.15252/embj.2019102147. Epub 2019 Sep 16. PubMed |
| Genetic determinants of cellular addiction to DNA polymerase theta. Feng W, Simpson DA, Carvajal-Garcia J, Price BA, Kumar RJ, Mose LE, Wood RD, Rashid N, Purvis JE, Parker JS, Ramsden DA, Gupta GP. Nat Commun. 2019 Sep 19;10(1):4286. doi: 10.1038/s41467-019-12234-1. PubMed |
| Ehrlichia chaffeensis Outer Membrane Protein 1-Specific Human Antibody-Mediated Immunity Is Defined by Intracellular TRIM21-Dependent Innate Immune Activation and Extracellular Neutralization. Velayutham TS, Kumar S, Zhang X, Kose N, Walker DH, Winslow G, Crowe JE Jr, McBride JW. Infect Immun. 2019 Nov 18;87(12). pii: IAI.00383-19. doi: 10.1128/IAI.00383-19. Print 2019 Dec. PubMed |
ER-lysosome contacts enable cholesterol sensing by mTORC1 and drive aberrant growth signalling in Niemann-Pick type C.
Lim CY, Davis OB, Shin HR, Zhang J, Berdan CA, Jiang X, Counihan JL, Ory DS, Nomura DK, Zoncu R.
Nat Cell Biol. 2019 Oct;21(10):1206-1218. doi: 10.1038/s41556-019-0391-5. Epub 2019 Sep 23.
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| CENP-A Ubiquitylation Is Indispensable to Cell Viability. Niikura Y, Kitagawa R, Fang L, Kitagawa K. Dev Cell. 2019 Sep 23;50(6):683-689.e6. doi: 10.1016/j.devcel.2019.07.015. PubMed |
| The Long Noncoding RNA HEAL Regulates HIV-1 Replication through Epigenetic Regulation of the HIV-1 Promoter. Chao TC, Zhang Q, Li Z, Tiwari SK, Qin Y, Yau E, Sanchez A, Singh G, Chang K, Kaul M, Karris MAY, Rana TM. mBio. 2019 Sep 24;10(5). pii: mBio.02016-19. doi: 10.1128/mBio.02016-19. PubMed |
| Genome-Wide CRISPR-Cas9 Screen Reveals Selective Vulnerability of ATRX-Mutant Cancers to WEE1 Inhibition. Liang J, Zhao H, Diplas BH, Liu S, Liu J, Wang D, Lu Y, Zhu Q, Wu J, Wang W, Yan H, Zeng YX, Wang X, Jiao Y. Cancer Res. 2020 Feb 1;80(3):510-523. doi: 10.1158/0008-5472.CAN-18-3374. Epub 2019 Sep 24. PubMed |
| Identification of FUBP1 as a Long Tail Cancer Driver and Widespread Regulator of Tumor Suppressor and Oncogene Alternative Splicing. Elman JS, Ni TK, Mengwasser KE, Jin D, Wronski A, Elledge SJ, Kuperwasser C. Cell Rep. 2019 Sep 24;28(13):3435-3449.e5. doi: 10.1016/j.celrep.2019.08.060. PubMed |
| Radiotherapy and Immunotherapy Promote Tumoral Lipid Oxidation and Ferroptosis via Synergistic Repression of SLC7A11. Lang X, Green MD, Wang W, Yu J, Choi JE, Jiang L, Liao P, Zhou J, Zhang Q, Dow A, Saripalli AL, Kryczek I, Wei S, Szeliga W, Vatan L, Stone EM, Georgiou G, Cieslik M, Wahl DR, Morgan MA, Chinnaiyan AM, Lawrence TS, Zou W. Cancer Discov. 2019 Dec;9(12):1673-1685. doi: 10.1158/2159-8290.CD-19-0338. Epub 2019 Sep 25. PubMed |
| Integrated network analysis identifies hsa-miR-4756-3p as a regulator of FOXM1 in Triple Negative Breast Cancer. Gu Y, Wang W, Wang X, Xie H, Ye X, Shu P. Sci Rep. 2019 Sep 25;9(1):13830. doi: 10.1038/s41598-019-50248-3. PubMed |
| Small-molecule inhibitor targeting the Hsp90-Cdc37 protein-protein interaction in colorectal cancer. Wang L, Zhang L, Li L, Jiang J, Zheng Z, Shang J, Wang C, Chen W, Bao Q, Xu X, Jiang Z, Zhang J, You Q. Sci Adv. 2019 Sep 18;5(9):eaax2277. doi: 10.1126/sciadv.aax2277. eCollection 2019 Sep. PubMed |
| Targeting lysosome function causes selective cytotoxicity in VHL-inactivated renal cell carcinomas. Bouhamdani N, Comeau D, Coholan A, Cormier K, Turcotte S. Carcinogenesis. 2019 Sep 26. pii: 5574006. doi: 10.1093/carcin/bgz161. PubMed |
HIF-independent synthetic lethality between CDK4/6 inhibition and VHL loss across species.
Nicholson HE, Tariq Z, Housden BE, Jennings RB, Stransky LA, Perrimon N, Signoretti S, Kaelin WG Jr.
Sci Signal. 2019 Oct 1;12(601). pii: 12/601/eaay0482. doi: 10.1126/scisignal.aay0482.
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| Silencing of TAZ inhibits the motility of hepatocellular carcinoma cells through autophagy induction. Zhou W, Weng J, Wu K, Xu X, Wang H, Zhang J, Zhao C, Yang J, Zhang Y, Shen W. Cancer Manag Res. 2019 Sep 26;11:8743-8753. doi: 10.2147/CMAR.S215466. eCollection 2019. PubMed |
| HTLV-1 viral oncogene HBZ drives bone destruction in adult T cell leukemia. Xiang J, Rauch DA, Huey DD, Panfil AR, Cheng X, Esser AK, Su X, Harding JC, Xu Y, Fox GC, Fontana F, Kobayashi T, Su J, Sundaramoorthi H, Wong WH, Jia Y, Rosol TJ, Veis DJ, Green PL, Niewiesk S, Ratner L, Weilbaecher KN. JCI Insight. 2019 Oct 3;4(19). pii: 128713. doi: 10.1172/jci.insight.128713. PubMed |
| DDR1 promotes breast tumor growth by suppressing antitumor immunity. Zhong X, Zhang W, Sun T. Oncol Rep. 2019 Dec;42(6):2844-2854. doi: 10.3892/or.2019.7338. Epub 2019 Sep 27. PubMed |
| Transplantation of Retinal Ganglion Cells Derived from Male Germline Stem Cell as a Potential Treatment to Glaucoma. Suen HC, Qian Y, Liao J, Luk CS, Lee WT, Ng JKW, Chan TTH, Hou HW, Li I, Li K, Chan WY, Feng B, Gao L, Jiang X, Liu YH, Rudd JA, Hobbs R, Qi H, Ng TK, Mak HK, Leung KS, Lee TL. Stem Cells Dev. 2019 Oct 15;28(20):1365-1375. doi: 10.1089/scd.2019.0060. Epub 2019 Oct 3. PubMed |
| De novo identification of essential protein domains from CRISPR-Cas9 tiling-sgRNA knockout screens. He W, Zhang L, Villarreal OD, Fu R, Bedford E, Dou J, Patel AY, Bedford MT, Shi X, Chen T, Bartholomew B, Xu H. Nat Commun. 2019 Oct 4;10(1):4541. doi: 10.1038/s41467-019-12489-8. PubMed |
| PTEN Loss Mediates Clinical Cross-Resistance to CDK4/6 and PI3Kalpha Inhibitors in Breast Cancer. Costa C, Wang Y, Ly A, Hosono Y, Murchie E, Walmsley CS, Huynh T, Healy C, Peterson R, Yanase S, Jakubik CT, Henderson LE, Damon LJ, Timonina D, Sanidas I, Pinto CJ, Mino-Kenudson M, Stone JR, Dyson NJ, Ellisen LW, Bardia A, Ebi H, Benes CH, Engelman JA, Juric D. Cancer Discov. 2020 Jan;10(1):72-85. doi: 10.1158/2159-8290.CD-18-0830. Epub 2019 Oct 8. PubMed |
| Endosomal signalling via exosome surface TGFbeta-1. Shelke GV, Yin Y, Jang SC, Lasser C, Wennmalm S, Hoffmann HJ, Li L, Gho YS, Nilsson JA, Lotvall J. J Extracell Vesicles. 2019 Sep 20;8(1):1650458. doi: 10.1080/20013078.2019.1650458. eCollection 2019. PubMed |
| Myocardin-Dependent Kv1.5 Channel Expression Prevents Phenotypic Modulation of Human Vessels in Organ Culture. Arevalo-Martinez M, Cidad P, Garcia-Mateo N, Moreno-Estar S, Serna J, Fernandez M, Sward K, Simarro M, de la Fuente MA, Lopez-Lopez JR, Perez-Garcia MT. Arterioscler Thromb Vasc Biol. 2019 Dec;39(12):e273-e286. doi: 10.1161/ATVBAHA.119.313492. Epub 2019 Oct 10. PubMed |
| LncRNA PVT1 up-regulation is a poor prognosticator and serves as a therapeutic target in esophageal adenocarcinoma. Xu Y, Li Y, Jin J, Han G, Sun C, Pizzi MP, Huo L, Scott A, Wang Y, Ma L, Lee JH, Bhutani MS, Weston B, Vellano C, Yang L, Lin C, Kim Y, MacLeod AR, Wang L, Wang Z, Song S, Ajani JA. Mol Cancer. 2019 Oct 10;18(1):141. doi: 10.1186/s12943-019-1064-5. PubMed |
| Specific interactions of BCL-2 family proteins mediate sensitivity to BH3-mimetics in diffuse large B-cell lymphoma. Smith VM, Dietz A, Henz K, Bruecher D, Jackson R, Kowald L, van Wijk SJL, Jayne S, Macip S, Fulda S, Dyer MJS, Vogler M. Haematologica. 2019 Oct 10. pii: haematol.2019.220525. doi: 10.3324/haematol.2019.220525. PubMed |
| A one-step tRNA-CRISPR system for genome-wide genetic interaction mapping in mammalian cells. Zhao Y, Tyrishkin K, Sjaarda C, Khanal P, Stafford J, Rauh M, Liu X, Babak T, Yang X. Sci Rep. 2019 Oct 10;9(1):14499. doi: 10.1038/s41598-019-51090-3. PubMed |
| RORgamma is a targetable master regulator of cholesterol biosynthesis in a cancer subtype. Cai D, Wang J, Gao B, Li J, Wu F, Zou JX, Xu J, Jiang Y, Zou H, Huang Z, Borowsky AD, Bold RJ, Lara PN, Li JJ, Chen X, Lam KS, To KF, Kung HJ, Fiehn O, Zhao R, Evans RM, Chen HW. Nat Commun. 2019 Oct 11;10(1):4621. doi: 10.1038/s41467-019-12529-3. PubMed |
| TFPa/HADHA is required for fatty acid beta-oxidation and cardiolipin re-modeling in human cardiomyocytes. Miklas JW, Clark E, Levy S, Detraux D, Leonard A, Beussman K, Showalter MR, Smith AT, Hofsteen P, Yang X, Macadangdang J, Manninen T, Raftery D, Madan A, Suomalainen A, Kim DH, Murry CE, Fiehn O, Sniadecki NJ, Wang Y, Ruohola-Baker H. Nat Commun. 2019 Oct 11;10(1):4671. doi: 10.1038/s41467-019-12482-1. PubMed |
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| Japanese Encephalitis Virus infection induces inflammation of swine testis through RIG-I-NF-kB signaling pathway. Zheng B, Wang X, Liu Y, Li Y, Long S, Gu C, Ye J, Xie S, Cao S. Vet Microbiol. 2019 Nov;238:108430. doi: 10.1016/j.vetmic.2019.108430. Epub 2019 Sep 28. PubMed |
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| Combination Therapy with Reovirus and ATM Inhibitor Enhances Cell Death and Virus Replication in Canine Melanoma. Igase M, Shibutani S, Kurogouchi Y, Fujiki N, Hwang CC, Coffey M, Noguchi S, Nemoto Y, Mizuno T. Mol Ther Oncolytics. 2019 Aug 28;15:49-59. doi: 10.1016/j.omto.2019.08.003. eCollection 2019 Dec 20. PubMed |
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| The reciprocal interaction between tumor cells and activated fibroblasts mediated by TNF-alpha/IL-33/ST2L signaling promotes gastric cancer metastasis. Zhou Q, Wu X, Wang X, Yu Z, Pan T, Li Z, Chang X, Jin Z, Li J, Zhu Z, Liu B, Su L. Oncogene. 2020 Feb;39(7):1414-1428. doi: 10.1038/s41388-019-1078-x. Epub 2019 Oct 28. PubMed |
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| CRISPR-Cas9-mediated knockout of SPRY2 in human hepatocytes leads to increased glucose uptake and lipid droplet accumulation. Cook NL, Pjanic M, Emmerich AG, Rao AS, Hetty S, Knowles JW, Quertermous T, Castillejo-Lopez C, Ingelsson E. BMC Endocr Disord. 2019 Oct 29;19(1):115. doi: 10.1186/s12902-019-0442-8. PubMed |
| Loss of ARID1A induces a stemness gene ALDH1A1 expression with histone acetylation in the malignant subtype of cholangiocarcinoma. Yoshino J, Akiyama Y, Shimada S, Ogura T, Ogawa K, Ono H, Mitsunori Y, Ban D, Kudo A, Yamaoka S, Tanabe M, Tanaka S. Carcinogenesis. 2019 Oct 30. pii: 5610211. doi: 10.1093/carcin/bgz179. PubMed |
| STING-Mediated IFI16 Degradation Negatively Controls Type I Interferon Production. Li D, Wu R, Guo W, Xie L, Qiao Z, Chen S, Zhu J, Huang C, Huang J, Chen B, Qin Y, Xu F, Ma F. Cell Rep. 2019 Oct 29;29(5):1249-1260.e4. doi: 10.1016/j.celrep.2019.09.069. PubMed |
| Glutamine Anabolism Plays a Critical Role in Pancreatic Cancer by Coupling Carbon and Nitrogen Metabolism. Bott AJ, Shen J, Tonelli C, Zhan L, Sivaram N, Jiang YP, Yu X, Bhatt V, Chiles E, Zhong H, Maimouni S, Dai W, Velasquez S, Pan JA, Muthalagu N, Morton J, Anthony TG, Feng H, Lamers WH, Murphy DJ, Guo JY, Jin J, Crawford HC, Zhang L, White E, Lin RZ, Su X, Tuveson DA, Zong WX. Cell Rep. 2019 Oct 29;29(5):1287-1298.e6. doi: 10.1016/j.celrep.2019.09.056. PubMed |
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| The classic metal-sensing transcription factor MTF1 promotes myogenesis in response to copper. Tavera-Montanez C, Hainer SJ, Cangussu D, Gordon SJV, Xiao Y, Reyes-Gutierrez P, Imbalzano AN, Navea JG, Fazzio TG, Padilla-Benavides T. FASEB J. 2019 Dec;33(12):14556-14574. doi: 10.1096/fj.201901606R. Epub 2019 Nov 5. PubMed |
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Negative regulation of autophagy by UBA6-BIRC6-mediated ubiquitination of LC3.
Jia R, Bonifacino JS.
Elife. 2019 Nov 6;8. pii: 50034. doi: 10.7554/eLife.50034.
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| Aryl Sulfonamides Degrade RBM39 and RBM23 by Recruitment to CRL4-DCAF15. Ting TC, Goralski M, Klein K, Wang B, Kim J, Xie Y, Nijhawan D. Cell Rep. 2019 Nov 5;29(6):1499-1510.e6. doi: 10.1016/j.celrep.2019.09.079. PubMed |
| Capping Protein Regulator and Myosin 1 Linker 3 Is Required for Tumor Metastasis. Wang H, Wang C, Peng G, Yu D, Cui XG, Sun YH, Ma X. Mol Cancer Res. 2020 Feb;18(2):240-252. doi: 10.1158/1541-7786.MCR-19-0722. Epub 2019 Nov 6. PubMed |
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| FTY720 induces non-canonical phosphatidylserine externalization and cell death in acute myeloid leukemia. Young MM, Bui V, Chen C, Wang HG. Cell Death Dis. 2019 Nov 7;10(11):847. doi: 10.1038/s41419-019-2080-5. PubMed |
| p53 mitotic centrosome localization preserves centrosome integrity and works as sensor for the mitotic surveillance pathway. Contadini C, Monteonofrio L, Virdia I, Prodosmo A, Valente D, Chessa L, Musio A, Fava LL, Rinaldo C, Di Rocco G, Soddu S. Cell Death Dis. 2019 Nov 7;10(11):850. doi: 10.1038/s41419-019-2076-1. PubMed |
| ESCRT-III-driven piecemeal micro-ER-phagy remodels the ER during recovery from ER stress. Loi M, Raimondi A, Morone D, Molinari M. Nat Commun. 2019 Nov 7;10(1):5058. doi: 10.1038/s41467-019-12991-z. PubMed |
| Generation of a knock-in MAP2-tdTomato reporter human embryonic stem cell line with inducible expression of NEUROG2/1 (NYGCe001-A). Lu C, Sanjana NE. Stem Cell Res. 2019 Dec;41:101643. doi: 10.1016/j.scr.2019.101643. Epub 2019 Nov 1. PubMed |
| Collagen IV (COL4A1, COL4A2), a Component of the Viral Biofilm, Is Induced by the HTLV-1 Oncoprotein Tax and Impacts Virus Transmission. Millen S, Gross C, Donhauser N, Mann MC, Peloponese JM Jr, Thoma-Kress AK. Front Microbiol. 2019 Oct 23;10:2439. doi: 10.3389/fmicb.2019.02439. eCollection 2019. PubMed |
| Integrated proteogenetic analysis reveals the landscape of a mitochondrial-autophagosome synapse during PARK2-dependent mitophagy. Heo JM, Harper NJ, Paulo JA, Li M, Xu Q, Coughlin M, Elledge SJ, Harper JW. Sci Adv. 2019 Nov 6;5(11):eaay4624. doi: 10.1126/sciadv.aay4624. eCollection 2019 Nov. PubMed |
| Regulation of Mitochondria-Associated Membranes (MAMs) by NO/sGC/PKG Participates in the Control of Hepatic Insulin Response. Bassot A, Chauvin MA, Bendridi N, Ji-Cao J, Vial G, Monnier L, Bartosch B, Alves A, Cottet-Rousselle C, Gouriou Y, Rieusset J, Morio B. Cells. 2019 Oct 25;8(11). pii: cells8111319. doi: 10.3390/cells8111319. PubMed |
| Prostaglandin E2 Induces miR675-5p to Promote Colorectal Tumor Metastasis via Modulation of p53 Expression. Cen B, Lang JD, Du Y, Wei J, Xiong Y, Bradley N, Wang D, DuBois RN. Gastroenterology. 2019 Nov 14. pii: S0016-5085(19)41559-X. doi: 10.1053/j.gastro.2019.11.013. PubMed |
Inducible Exoc7/Exo70 knockout reveals a critical role of the exocyst in insulin-regulated GLUT4 exocytosis.
Wang S, Crisman L, Miller J, Datta I, Gulbranson DR, Tian Y, Yin Q, Yu H, Shen J.
J Biol Chem. 2019 Dec 27;294(52):19988-19996. doi: 10.1074/jbc.RA119.010821. Epub 2019 Nov 18.
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| ATAD2 predicts poor outcomes in patients with ovarian cancer and is a marker of proliferation. Liu Q, Liu H, Li L, Dong X, Ru X, Fan X, Wen T, Liu J. Int J Oncol. 2020 Jan;56(1):219-231. doi: 10.3892/ijo.2019.4913. Epub 2019 Nov 14. PubMed |
| EPS8 Facilitates Uncoating of Influenza A Virus. Larson GP, Tran V, Yu S, Cai Y, Higgins CA, Smith DM, Baker SF, Radoshitzky SR, Kuhn JH, Mehle A. Cell Rep. 2019 Nov 19;29(8):2175-2183.e4. doi: 10.1016/j.celrep.2019.10.064. PubMed |
| CpG dinucleotides inhibit HIV-1 replication through zinc finger antiviral protein (ZAP)-dependent and -independent mechanisms. Ficarelli M, Antzin-Anduetza I, Hugh-White R, Firth AE, Sertkaya H, Wilson H, Neil SJD, Schulz R, Swanson CM. J Virol. 2019 Nov 20. pii: JVI.01337-19. doi: 10.1128/JVI.01337-19. PubMed |
| A molecular mechanism underlying genotype-specific intrahepatic cholestasis resulting from MYO5B mutations. Overeem AW, Li Q, Qiu YL, Carton-Garcia F, Leng C, Klappe K, Dronkers J, Hsiao NH, Wang JS, Arango D, van IJzendoorn SCD. Hepatology. 2019 Nov 21. doi: 10.1002/hep.31002. PubMed |
| Different class IIa HDACs repressive complexes regulate specific epigenetic responses related to cell survival in leiomyosarcoma cells. Di Giorgio E, Dalla E, Franforte E, Paluvai H, Minisini M, Trevisanut M, Picco R, Brancolini C. Nucleic Acids Res. 2020 Jan 24;48(2):646-664. doi: 10.1093/nar/gkz1120. PubMed |
| The phosphatidylethanolamine biosynthesis pathway provides a new target for cancer chemotherapy. Guan Y, Chen X, Wu M, Zhu W, Arslan A, Takeda S, Nguyen MH, Majeti R, Thomas D, Zheng M, Peltz G. J Hepatol. 2019 Nov 22. pii: S0168-8278(19)30676-2. doi: 10.1016/j.jhep.2019.11.007. PubMed |
| Functional impact of the long non-coding RNA MEG3 deletion by CRISPR/Cas9 in the human triple negative metastatic Hs578T cancer cell line. Deocesano-Pereira C, Machado RAC, De Jesus-Ferreira HC, Marchini T, Pereira TF, Carreira ACO, Sogayar MC. Oncol Lett. 2019 Dec;18(6):5941-5951. doi: 10.3892/ol.2019.10969. Epub 2019 Oct 8. PubMed |
| Modulating FOXO3 transcriptional activity by small, DBD-binding molecules. Hagenbuchner J, Obsilova V, Kaserer T, Kaiser N, Rass B, Psenakova K, Docekal V, Alblova M, Kohoutova K, Schuster D, Aneichyk T, Vesely J, Obexer P, Obsil T, Ausserlechner MJ. Elife. 2019 Dec 4;8. pii: 48876. doi: 10.7554/eLife.48876. PubMed |
| Herpesviral lytic gene functions render the viral genome susceptible to novel editing by CRISPR/Cas9. Oh HS, Neuhausser WM, Eggan P, Angelova M, Kirchner R, Eggan KC, Knipe DM. Elife. 2019 Dec 2;8. pii: 51662. doi: 10.7554/eLife.51662. PubMed |
| TspanC8 tetraspanins differentially regulate ADAM10 endocytosis and half-life. Eschenbrenner E, Jouannet S, Clay D, Chaker J, Boucheix C, Brou C, Tomlinson MG, Charrin S, Rubinstein E. Life Sci Alliance. 2019 Dec 2;3(1). pii: 3/1/e201900444. doi: 10.26508/lsa.201900444. Print 2020 Jan. PubMed |
| Genome-wide CRISPR screen identifies ELP5 as a determinant of gemcitabine sensitivity in gallbladder cancer. Xu S, Zhan M, Jiang C, He M, Yang L, Shen H, Huang S, Huang X, Lin R, Shi Y, Liu Q, Chen W, Mohan M, Wang J. Nat Commun. 2019 Dec 2;10(1):5492. doi: 10.1038/s41467-019-13420-x. PubMed |
| A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity. Khan S, Zhang X, Lv D, Zhang Q, He Y, Zhang P, Liu X, Thummuri D, Yuan Y, Wiegand JS, Pei J, Zhang W, Sharma A, McCurdy CR, Kuruvilla VM, Baran N, Ferrando AA, Kim YM, Rogojina A, Houghton PJ, Huang G, Hromas R, Konopleva M, Zheng G, Zhou D. Nat Med. 2019 Dec;25(12):1938-1947. doi: 10.1038/s41591-019-0668-z. Epub 2019 Dec 2. PubMed |
| Suppression of Ribosomal Pausing by eIF5A Is Necessary to Maintain the Fidelity of Start Codon Selection. Manjunath H, Zhang H, Rehfeld F, Han J, Chang TC, Mendell JT. Cell Rep. 2019 Dec 3;29(10):3134-3146.e6. doi: 10.1016/j.celrep.2019.10.129. PubMed |
| Reactive oxygen/nitrogen species contribute substantially to the antileukemia effect of APO866, a NAD lowering agent. Cloux AJ, Aubry D, Heulot M, Widmann C, ElMokh O, Piacente F, Cea M, Nencioni A, Bellotti A, Bouzourene K, Pellegrin M, Mazzolai L, Duchosal MA, Nahimana A. Oncotarget. 2019 Nov 19;10(62):6723-6738. doi: 10.18632/oncotarget.27336. eCollection 2019 Nov 19. PubMed |
| CPT1A/2-Mediated FAO Enhancement-A Metabolic Target in Radioresistant Breast Cancer. Han S, Wei R, Zhang X, Jiang N, Fan M, Huang JH, Xie B, Zhang L, Miao W, Butler AC, Coleman MA, Vaughan AT, Wang Y, Chen HW, Liu J, Li JJ. Front Oncol. 2019 Nov 15;9:1201. doi: 10.3389/fonc.2019.01201. eCollection 2019. PubMed |
IGF2BP2 regulates DANCR by serving as an N6-methyladenosine reader.
Hu X, Peng WX, Zhou H, Jiang J, Zhou X, Huang D, Mo YY, Yang L.
Cell Death Differ. 2019 Dec 5. pii: 10.1038/s41418-019-0461-z. doi: 10.1038/s41418-019-0461-z.
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| Promotion of cellular senescence by THG-1/TSC22D4 knockout through activation of JUNB. Zhang X, Koga N, Suzuki H, Kato M. Biochem Biophys Res Commun. 2020 Feb 19;522(4):897-902. doi: 10.1016/j.bbrc.2019.11.145. Epub 2019 Dec 3. PubMed |
| Reactive metabolite production is a targetable liability of glycolytic metabolism in lung cancer. Luengo A, Abbott KL, Davidson SM, Hosios AM, Faubert B, Chan SH, Freinkman E, Zacharias LG, Mathews TP, Clish CB, DeBerardinis RJ, Lewis CA, Vander Heiden MG. Nat Commun. 2019 Dec 6;10(1):5604. doi: 10.1038/s41467-019-13419-4. PubMed |
| 53BP1/RIF1 signaling promotes cell survival after multifractionated radiotherapy. Eke I, Zong D, Aryankalayil MJ, Sandfort V, Bylicky MA, Rath BH, Graves EE, Nussenzweig A, Coleman CN. Nucleic Acids Res. 2020 Feb 20;48(3):1314-1326. doi: 10.1093/nar/gkz1139. PubMed |
| Targeting N-Terminal Huntingtin with a Dual-sgRNA Strategy by CRISPR/Cas9. Wu J, Tang Y, Zhang CL. Biomed Res Int. 2019 Nov 16;2019:1039623. doi: 10.1155/2019/1039623. eCollection 2019. PubMed |
| Integrated drug profiling and CRISPR screening identify essential pathways for CAR T cell cytotoxicity. Dufva O, Koski J, Maliniemi P, Ianevski A, Klievink J, Leitner J, Polonen P, Hohtari H, Saeed K, Hannunen T, Ellonen P, Steinberger P, Kankainen M, Aittokallio T, Keranen MAI, Korhonen M, Mustjoki S. Blood. 2019 Dec 12. pii: 429647. doi: 10.1182/blood.2019002121. PubMed |
| Disulfide bond-disrupting agents activate the tumor necrosis family-related apoptosis-inducing ligand/death receptor 5 pathway. Wang M, Law ME, Davis BJ, Yaaghubi E, Ghilardi AF, Ferreira RB, Chiang CW, Guryanova OA, Kopinke D, Heldermon CD, Castellano RK, Law BK. Cell Death Discov. 2019 Dec 10;5:153. doi: 10.1038/s41420-019-0228-9. eCollection 2019. PubMed |
The E3 Ubiquitin Ligase Mind Bomb 1 Controls Adenovirus Genome Release at the Nuclear Pore Complex.
Bauer M, Flatt JW, Seiler D, Cardel B, Emmenlauer M, Boucke K, Suomalainen M, Hemmi S, Greber UF.
Cell Rep. 2019 Dec 17;29(12):3785-3795.e8. doi: 10.1016/j.celrep.2019.11.064.
PubMed
Associated Plasmids |
| LC3C-Mediated Autophagy Selectively Regulates the Met RTK and HGF-Stimulated Migration and Invasion. Bell ES, Coelho PP, Ratcliffe CDH, Rajadurai CV, Peschard P, Vaillancourt R, Zuo D, Park M. Cell Rep. 2019 Dec 17;29(12):4053-4068.e6. doi: 10.1016/j.celrep.2019.11.063. PubMed |
| Spatial Genome Re-organization between Fetal and Adult Hematopoietic Stem Cells. Chen C, Yu W, Tober J, Gao P, He B, Lee K, Trieu T, Blobel GA, Speck NA, Tan K. Cell Rep. 2019 Dec 17;29(12):4200-4211.e7. doi: 10.1016/j.celrep.2019.11.065. PubMed |
| Low-Level Saturated Fatty Acid Palmitate Benefits Liver Cells by Boosting Mitochondrial Metabolism via CDK1-SIRT3-CPT2 Cascade. Liu L, Xie B, Fan M, Candas-Green D, Jiang JX, Wei R, Wang Y, Chen HW, Hu Y, Li JJ. Dev Cell. 2020 Jan 27;52(2):196-209.e9. doi: 10.1016/j.devcel.2019.11.012. Epub 2019 Dec 19. PubMed |
| A Variant of SLC1A5 Is a Mitochondrial Glutamine Transporter for Metabolic Reprogramming in Cancer Cells. Yoo HC, Park SJ, Nam M, Kang J, Kim K, Yeo JH, Kim JK, Heo Y, Lee HS, Lee MY, Lee CW, Kang JS, Kim YH, Lee J, Choi J, Hwang GS, Bang S, Han JM. Cell Metab. 2020 Feb 4;31(2):267-283.e12. doi: 10.1016/j.cmet.2019.11.020. Epub 2019 Dec 19. PubMed |
| Tumor Cell-Intrinsic USP22 Suppresses Antitumor Immunity in Pancreatic Cancer. Li J, Yuan S, Norgard RJ, Yan F, Yamazoe T, Blanco A, Stanger BZ. Cancer Immunol Res. 2020 Mar;8(3):282-291. doi: 10.1158/2326-6066.CIR-19-0661. Epub 2019 Dec 23. PubMed |
| Cholesterol restricts lymphotoxin beta receptor-triggered NF-kappaB signaling. Banach-Orlowska M, Wyszynska R, Pyrzynska B, Maksymowicz M, Golab J, Miaczynska M. Cell Commun Signal. 2019 Dec 26;17(1):171. doi: 10.1186/s12964-019-0460-1. PubMed |
| CDK7 Inhibition Potentiates Genome Instability Triggering Anti-tumor Immunity in Small Cell Lung Cancer. Zhang H, Christensen CL, Dries R, Oser MG, Deng J, Diskin B, Li F, Pan Y, Zhang X, Yin Y, Papadopoulos E, Pyon V, Thakurdin C, Kwiatkowski N, Jani K, Rabin AR, Castro DM, Chen T, Silver H, Huang Q, Bulatovic M, Dowling CM, Sundberg B, Leggett A, Ranieri M, Han H, Li S, Yang A, Labbe KE, Almonte C, Sviderskiy VO, Quinn M, Donaghue J, Wang ES, Zhang T, He Z, Velcheti V, Hammerman PS, Freeman GJ, Bonneau R, Kaelin WG Jr, Sutherland KD, Kersbergen A, Aguirre AJ, Yuan GC, Rothenberg E, Miller G, Gray NS, Wong KK. Cancer Cell. 2020 Jan 13;37(1):37-54.e9. doi: 10.1016/j.ccell.2019.11.003. Epub 2019 Dec 26. PubMed |
| Gastric squamous-columnar junction contains a large pool of cancer-prone immature osteopontin responsive Lgr5(-)CD44(+) cells. Fu DJ, Wang L, Chouairi FK, Rose IM, Abetov DA, Miller AD, Yamulla RJ, Schimenti JC, Flesken-Nikitin A, Nikitin AY. Nat Commun. 2020 Jan 3;11(1):84. doi: 10.1038/s41467-019-13847-2. PubMed |
| A Septin Cytoskeleton-Targeting Small Molecule, Forchlorfenuron, Inhibits Epithelial Migration via Septin-Independent Perturbation of Cellular Signaling. Sun L, Cao X, Lechuga S, Feygin A, Naydenov NG, Ivanov AI. Cells. 2019 Dec 29;9(1). pii: cells9010084. doi: 10.3390/cells9010084. PubMed |
| Mediator of DNA Damage Checkpoint Protein 1 Facilitates V(D)J Recombination in Cells Lacking DNA Repair Factor XLF. Beck C, Castaneda-Zegarra S, Huse C, Xing M, Oksenych V. Biomolecules. 2019 Dec 30;10(1). pii: biom10010060. doi: 10.3390/biom10010060. PubMed |
| FKBP8 LIRL-dependent mitochondrial fragmentation facilitates mitophagy under stress conditions. Yoo SM, Yamashita SI, Kim H, Na D, Lee H, Kim SJ, Cho DH, Kanki T, Jung YK. FASEB J. 2020 Feb;34(2):2944-2957. doi: 10.1096/fj.201901735R. Epub 2019 Dec 26. PubMed |
| Anillin regulates breast cancer cell migration, growth, and metastasis by non-canonical mechanisms involving control of cell stemness and differentiation. Wang D, Naydenov NG, Dozmorov MG, Koblinski JE, Ivanov AI. Breast Cancer Res. 2020 Jan 7;22(1):3. doi: 10.1186/s13058-019-1241-x. PubMed |
| APOBEC3B reporter myeloma cell lines identify DNA damage response pathways leading to APOBEC3B expression. Yamazaki H, Shirakawa K, Matsumoto T, Kazuma Y, Matsui H, Horisawa Y, Stanford E, Sarca AD, Shirakawa R, Shindo K, Takaori-Kondo A. PLoS One. 2020 Jan 8;15(1):e0223463. doi: 10.1371/journal.pone.0223463. eCollection 2020. PubMed |
| Genome-wide CRISPR screen identifies host dependency factors for influenza A virus infection. Li B, Clohisey SM, Chia BS, Wang B, Cui A, Eisenhaure T, Schweitzer LD, Hoover P, Parkinson NJ, Nachshon A, Smith N, Regan T, Farr D, Gutmann MU, Bukhari SI, Law A, Sangesland M, Gat-Viks I, Digard P, Vasudevan S, Lingwood D, Dockrell DH, Doench JG, Baillie JK, Hacohen N. Nat Commun. 2020 Jan 9;11(1):164. doi: 10.1038/s41467-019-13965-x. PubMed |
| Lipid droplets can promote drug accumulation and activation. Dubey R, Stivala CE, Nguyen HQ, Goo YH, Paul A, Carette JE, Trost BM, Rohatgi R. Nat Chem Biol. 2020 Feb;16(2):206-213. doi: 10.1038/s41589-019-0447-7. Epub 2020 Jan 13. PubMed |
| Vitamin B6 Addiction in Acute Myeloid Leukemia. Chen CC, Li B, Millman SE, Chen C, Li X, Morris JP 4th, Mayle A, Ho YJ, Loizou E, Liu H, Qin W, Shah H, Violante S, Cross JR, Lowe SW, Zhang L. Cancer Cell. 2020 Jan 13;37(1):71-84.e7. doi: 10.1016/j.ccell.2019.12.002. PubMed |
| Oxygen-dependent asparagine hydroxylation of the ubiquitin-associated (UBA) domain in Cezanne regulates ubiquitin binding. Mader J, Huber J, Bonn F, Dotsch V, Rogov VV, Bremm A. J Biol Chem. 2020 Feb 21;295(8):2160-2174. doi: 10.1074/jbc.RA119.010315. Epub 2020 Jan 14. PubMed |
| STING-dependent paracriny shapes apoptotic priming of breast tumors in response to anti-mitotic treatment. Lohard S, Bourgeois N, Maillet L, Gautier F, Fetiveau A, Lasla H, Nguyen F, Vuillier C, Dumont A, Moreau-Aubry A, Frapin M, David L, Loussouarn D, Kerdraon O, Campone M, Jezequel P, Juin PP, Barille-Nion S. Nat Commun. 2020 Jan 14;11(1):259. doi: 10.1038/s41467-019-13689-y. PubMed |
| Angiomotin links ROCK and YAP signaling in mechanosensitive differentiation of neural stem cells. Kang PH, Schaffer DV, Kumar S. Mol Biol Cell. 2020 Mar 1;31(5):386-396. doi: 10.1091/mbc.E19-11-0602. Epub 2020 Jan 15. PubMed |
| JNK/AP1 Pathway Regulates MYC Expression and BCR Signaling through Ig Enhancers in Burkitt Lymphoma Cells. Ding X, Wang X, Zhu X, Zhang J, Zhu Y, Shao X, Zhou X. J Cancer. 2020 Jan 1;11(3):610-618. doi: 10.7150/jca.34055. eCollection 2020. PubMed |
| Haplotyping by CRISPR-mediated DNA circularization (CRISPR-hapC) broadens allele-specific gene editing. Yu J, Xiang X, Huang J, Liang X, Pan X, Dong Z, Petersen TS, Qu K, Yang L, Zhao X, Li S, Zheng T, Xu Z, Liu C, Han P, Xu F, Yang H, Liu X, Zhang X, Bolund L, Luo Y, Lin L. Nucleic Acids Res. 2020 Mar 18;48(5):e25. doi: 10.1093/nar/gkz1233. PubMed |
| Gigaxonin glycosylation regulates intermediate filament turnover and may impact giant axonal neuropathy etiology or treatment Chen PH, Hu J, Wu J, Huynh DT, Smith TJ, Pan S, Bisnett BJ, Smith AB, Lu A, Condon BM, Chi JT, Boyce M. JCI Insight. 2019 Nov 26;5(1). pii: 127751. doi: 10.1172/jci.insight.127751. Print 2020 Jan 16. PubMed |
| Disabling the Protease DDI2 Attenuates the Transcriptional Activity of NRF1 and Potentiates Proteasome Inhibitor Cytotoxicity. Northrop A, Vangala JR, Feygin A, Radhakrishnan SK. Int J Mol Sci. 2020 Jan 3;21(1). pii: ijms21010327. doi: 10.3390/ijms21010327. PubMed |
| The role of ferroptosis in ionizing radiation-induced cell death and tumor suppression. Lei G, Zhang Y, Koppula P, Liu X, Zhang J, Lin SH, Ajani JA, Xiao Q, Liao Z, Wang H, Gan B. Cell Res. 2020 Feb;30(2):146-162. doi: 10.1038/s41422-019-0263-3. Epub 2020 Jan 16. PubMed |
| Kinesin Kif2C in regulation of DNA double strand break dynamics and repair. Zhu S, Paydar M, Wang F, Li Y, Wang L, Barrette B, Bessho T, Kwok BH, Peng A. Elife. 2020 Jan 17;9. pii: 53402. doi: 10.7554/eLife.53402. PubMed |
| Integrin alphavbeta5 Internalizes Zika Virus during Neural Stem Cells Infection and Provides a Promising Target for Antiviral Therapy. Wang S, Zhang Q, Tiwari SK, Lichinchi G, Yau EH, Hui H, Li W, Furnari F, Rana TM. Cell Rep. 2020 Jan 28;30(4):969-983.e4. doi: 10.1016/j.celrep.2019.11.020. Epub 2020 Jan 16. PubMed |
| Genome-scale CRISPR screening for potential targets of ginsenoside compound K. Yang Y, Liu X, Li S, Chen Y, Zhao Y, Wei Y, Qiu Y, Liu Y, Zhou Z, Han J, Wu G, Ding Q. Cell Death Dis. 2020 Jan 20;11(1):39. doi: 10.1038/s41419-020-2234-5. PubMed |
| Transmissible gastroenteritis virus targets Paneth cells to inhibit the self-renewal and differentiation of Lgr5 intestinal stem cells via Notch signaling. Wu A, Yu B, Zhang K, Xu Z, Wu, He J, Luo J, Luo Y, Yu J, Zheng P, Che L, Mao X, Huang Z, Wang L, Zhao J, Chen D. Cell Death Dis. 2020 Jan 20;11(1):40. doi: 10.1038/s41419-020-2233-6. PubMed |
A human ciliopathy reveals essential functions for NEK10 in airway mucociliary clearance.
Chivukula RR, Montoro DT, Leung HM, Yang J, Shamseldin HE, Taylor MS, Dougherty GW, Zariwala MA, Carson J, Daniels MLA, Sears PR, Black KE, Hariri LP, Almogarri I, Frenkel EM, Vinarsky V, Omran H, Knowles MR, Tearney GJ, Alkuraya FS, Sabatini DM.
Nat Med. 2020 Jan 20. pii: 10.1038/s41591-019-0730-x. doi: 10.1038/s41591-019-0730-x.
PubMed
Associated Plasmids |
| A Dual Reporter EndoC-betaH1 Human beta-Cell Line for Efficient Quantification of Calcium Flux and Insulin Secretion. Cardenas-Diaz FL, Leavens KF, Kishore S, Osorio-Quintero C, Chen YJ, Stanger BZ, Wang P, French D, Gadue P. Endocrinology. 2020 Feb 1;161(2). pii: 5710816. doi: 10.1210/endocr/bqaa005. PubMed |
| Down-regulation of SLC35C1 induces colon cancer through over-activating Wnt pathway. Deng M, Chen Z, Tan J, Liu H. J Cell Mol Med. 2020 Mar;24(5):3079-3090. doi: 10.1111/jcmm.14969. Epub 2020 Jan 21. PubMed |
| Generalizable sgRNA design for improved CRISPR/Cas9 editing efficiency. Hiranniramol K, Chen Y, Liu W, Wang X. Bioinformatics. 2020 May 1;36(9):2684-2689. doi: 10.1093/bioinformatics/btaa041. PubMed |
Mass spectrometry proteomics reveals a function for mammalian CALCOCO1 in MTOR-regulated selective autophagy.
Stefely JA, Zhang Y, Freiberger EC, Kwiecien NW, Thomas HE, Davis AM, Lowry ND, Vincent CE, Shishkova E, Clark NA, Medvedovic M, Coon JJ, Pagliarini DJ, Mercer CA.
Autophagy. 2020 Jan 23. doi: 10.1080/15548627.2020.1719746.
PubMed
Associated Plasmids |
| Noncoding mutations target cis-regulatory elements of the FOXA1 plexus in prostate cancer. Zhou S, Hawley JR, Soares F, Grillo G, Teng M, Madani Tonekaboni SA, Hua JT, Kron KJ, Mazrooei P, Ahmed M, Arlidge C, Yun HY, Livingstone J, Huang V, Yamaguchi TN, Espiritu SMG, Zhu Y, Severson TM, Murison A, Cameron S, Zwart W, van der Kwast T, Pugh TJ, Fraser M, Boutros PC, Bristow RG, He HH, Lupien M. Nat Commun. 2020 Jan 23;11(1):441. doi: 10.1038/s41467-020-14318-9. PubMed |
| A CRISPR/Cas9 genome editing pipeline in the EndoC-betaH1 cell line to study genes implicated in beta cell function. Grotz AK, Abaitua F, Navarro-Guerrero E, Hastoy B, Ebner D, Gloyn AL. Wellcome Open Res. 2020 Apr 29;4:150. doi: 10.12688/wellcomeopenres.15447.2. eCollection 2019. PubMed |
CRISPR/CAS9-based DNA damage response screens reveal gene-drug interactions.
Su D, Feng X, Colic M, Wang Y, Zhang C, Wang C, Tang M, Hart T, Chen J.
DNA Repair (Amst). 2020 Jan 16;87:102803. doi: 10.1016/j.dnarep.2020.102803.
PubMed
Associated Plasmids |
ATP13A2 deficiency disrupts lysosomal polyamine export.
van Veen S, Martin S, Van den Haute C, Benoy V, Lyons J, Vanhoutte R, Kahler JP, Decuypere JP, Gelders G, Lambie E, Zielich J, Swinnen JV, Annaert W, Agostinis P, Ghesquiere B, Verhelst S, Baekelandt V, Eggermont J, Vangheluwe P.
Nature. 2020 Feb;578(7795):419-424. doi: 10.1038/s41586-020-1968-7. Epub 2020 Jan 29.
PubMed
Associated Plasmids |
| Matrix Gla protein regulates adipogenesis and is serum marker of visceral adiposity. Li C, Li J, He F, Li K, Li X, Zhang Y. Adipocyte. 2020 Dec;9(1):68-76. doi: 10.1080/21623945.2020.1721692. PubMed |
Sensitivity of Mesothelioma Cells to PARP Inhibitors Is Not Dependent on BAP1 but Is Enhanced by Temozolomide in Cells With High-Schlafen 11 and Low-O6-methylguanine-DNA Methyltransferase Expression.
Rathkey D, Khanal M, Murai J, Zhang J, Sengupta M, Jiang Q, Morrow B, Evans CN, Chari R, Fetsch P, Chung HJ, Xi L, Roth M, Filie A, Raffeld M, Thomas A, Pommier Y, Hassan R.
J Thorac Oncol. 2020 May;15(5):843-859. doi: 10.1016/j.jtho.2020.01.012. Epub 2020 Jan 28.
PubMed
Associated Plasmids |
| MARCH5-dependent degradation of MCL1/NOXA complexes defines susceptibility to antimitotic drug treatment. Haschka MD, Karbon G, Soratroi C, O'Neill KL, Luo X, Villunger A. Cell Death Differ. 2020 Aug;27(8):2297-2312. doi: 10.1038/s41418-020-0503-6. Epub 2020 Feb 3. PubMed |
| Context-Dependent Role of Vinculin in Neutrophil Adhesion, Motility and Trafficking. Wilson ZS, Witt H, Hazlett L, Harman M, Neumann BM, Whitman A, Patel M, Ross RS, Franck C, Reichner JS, Lefort CT. Sci Rep. 2020 Feb 7;10(1):2142. doi: 10.1038/s41598-020-58882-y. PubMed |
| Threonine Phosphorylation of IkappaBzeta Mediates Inhibition of Selective Proinflammatory Target Genes. Grondona P, Bucher P, Schmitt A, Schonfeld C, Streibl B, Muller A, Essmann F, Liberatori S, Mohammed S, Hennig A, Kramer D, Schulze-Osthoff K, Hailfinger S. J Invest Dermatol. 2020 Sep;140(9):1805-1814.e6. doi: 10.1016/j.jid.2019.12.036. Epub 2020 Feb 6. PubMed |
| Temporal dynamics of protein complex formation and dissociation during human cytomegalovirus infection. Hashimoto Y, Sheng X, Murray-Nerger LA, Cristea IM. Nat Commun. 2020 Feb 10;11(1):806. doi: 10.1038/s41467-020-14586-5. PubMed |
| Cancer cell-intrinsic function of CD177 in attenuating beta-catenin signaling. Kluz PN, Kolb R, Xie Q, Borcherding N, Liu Q, Luo Y, Kim MC, Wang L, Zhang Y, Li W, Stipp C, Gibson-Corley KN, Zhao C, Qi HH, Bellizzi A, Tao AW, Sugg S, Weigel RJ, Zhou D, Shen X, Zhang W. Oncogene. 2020 Apr;39(14):2877-2889. doi: 10.1038/s41388-020-1203-x. Epub 2020 Feb 10. PubMed |
| BRCA1 and S phase DNA repair pathways restrict LINE-1 retrotransposition in human cells. Mita P, Sun X, Fenyo D, Kahler DJ, Li D, Agmon N, Wudzinska A, Keegan S, Bader JS, Yun C, Boeke JD. Nat Struct Mol Biol. 2020 Feb;27(2):179-191. doi: 10.1038/s41594-020-0374-z. Epub 2020 Feb 10. PubMed |
| MAFG-driven astrocytes promote CNS inflammation. Wheeler MA, Clark IC, Tjon EC, Li Z, Zandee SEJ, Couturier CP, Watson BR, Scalisi G, Alkwai S, Rothhammer V, Rotem A, Heyman JA, Thaploo S, Sanmarco LM, Ragoussis J, Weitz DA, Petrecca K, Moffitt JR, Becher B, Antel JP, Prat A, Quintana FJ. Nature. 2020 Feb;578(7796):593-599. doi: 10.1038/s41586-020-1999-0. Epub 2020 Feb 12. PubMed |
| Deletion of Von Hippel-Lindau Interferes with Hyper Osmolality Induced Gene Expression and Induces an Unfavorable Gene Expression Pattern. Gross A, Chernyakov D, Gallwitz L, Bornkessel N, Edemir B. Cancers (Basel). 2020 Feb 12;12(2). pii: cancers12020420. doi: 10.3390/cancers12020420. PubMed |
| Inhibition of USP7 activity selectively eliminates senescent cells in part via restoration of p53 activity. He Y, Li W, Lv D, Zhang X, Zhang X, Ortiz YT, Budamagunta V, Campisi J, Zheng G, Zhou D. Aging Cell. 2020 Mar;19(3):e13117. doi: 10.1111/acel.13117. Epub 2020 Feb 16. PubMed |
| Endogenous Retrovirus Activation as a Key Mechanism of Anti-Tumor Immune Response in Radiotherapy. Lee AK, Pan D, Bao X, Hu M, Li F, Li CY. Radiat Res. 2020 Apr;193(4):305-317. doi: 10.1667/RADE-20-00013. Epub 2020 Feb 19. PubMed |
| Regulation of branched-chain amino acid metabolism by hypoxia-inducible factor in glioblastoma. Zhang B, Chen Y, Shi X, Zhou M, Bao L, Hatanpaa KJ, Patel T, DeBerardinis RJ, Wang Y, Luo W. Cell Mol Life Sci. 2020 Feb 22. pii: 10.1007/s00018-020-03483-1. doi: 10.1007/s00018-020-03483-1. PubMed |
| Chromatin accessibility is associated with the changed expression of miRNAs that target members of the Hippo pathway during myoblast differentiation. Zhou H, Xiang Y, Hu M, Xu Y, Hou Y, Qi X, Fu L, Luan Y, Wang Z, Li X, Zhao Y, Zhao S. Cell Death Dis. 2020 Feb 24;11(2):148. doi: 10.1038/s41419-020-2341-3. PubMed |
| Site-specific methylation of 18S ribosomal RNA by SNORD42A is required for acute myeloid leukemia cell proliferation. Pauli C, Liu Y, Rohde C, Cui C, Fijalkowska D, Gerloff D, Walter C, Krijgsveld J, Dugas M, Edemir B, Pabst C, Muller LP, Zhou F, Muller-Tidow C. Blood. 2020 Jun 4;135(23):2059-2070. doi: 10.1182/blood.2019004121. PubMed |
| Optogenetic engineering to probe the molecular choreography of STIM1-mediated cell signaling. Ma G, He L, Liu S, Xie J, Huang Z, Jing J, Lee YT, Wang R, Luo H, Han W, Huang Y, Zhou Y. Nat Commun. 2020 Feb 25;11(1):1039. doi: 10.1038/s41467-020-14841-9. PubMed |
| MYC Regulation of D2HGDH and L2HGDH Influences the Epigenome and Epitranscriptome. Qiu Z, Lin AP, Jiang S, Elkashef SM, Myers J, Srikantan S, Sasi B, Cao JZ, Godley LA, Rakheja D, Lyu Y, Zheng S, Madesh M, Shiio Y, Dahia PLM, Aguiar RCT. Cell Chem Biol. 2020 May 21;27(5):538-550.e7. doi: 10.1016/j.chembiol.2020.02.002. Epub 2020 Feb 25. PubMed |
| Characterization of novel LncRNA P14AS as a protector of ANRIL through AUF1 binding in human cells. Ma W, Qiao J, Zhou J, Gu L, Deng D. Mol Cancer. 2020 Feb 27;19(1):42. doi: 10.1186/s12943-020-01150-4. PubMed |
| The Coup-TFII orphan nuclear receptor is an activator of the gamma-globin gene. Fugazza C, Barbarani G, Elangovan S, Marini MG, Giolitto S, Font-Monclus I, Marongiu MF, Manunza L, Strouboulis J, Cantu C, Gasparri F, Barabino SML, Nakamura Y, Ottolenghi S, Moi P, Ronchi AE. Haematologica. 2020 Feb 27. pii: haematol.2019.241224. doi: 10.3324/haematol.2019.241224. PubMed |
| Haploid genetic screens identify SPRING/C12ORF49 as a determinant of SREBP signaling and cholesterol metabolism. Loregger A, Raaben M, Nieuwenhuis J, Tan JME, Jae LT, van den Hengel LG, Hendrix S, van den Berg M, Scheij S, Song JY, Huijbers IJ, Kroese LJ, Ottenhoff R, van Weeghel M, van de Sluis B, Brummelkamp T, Zelcer N. Nat Commun. 2020 Feb 28;11(1):1128. doi: 10.1038/s41467-020-14811-1. PubMed |
| Critical roles of phosphoinositides and NF2 in Hippo pathway regulation. Hong AW, Meng Z, Plouffe SW, Lin Z, Zhang M, Guan KL. Genes Dev. 2020 Apr 1;34(7-8):511-525. doi: 10.1101/gad.333435.119. Epub 2020 Feb 27. PubMed |
| The E3 Ubiquitin Ligase SIAH1 Targets MyD88 for Proteasomal Degradation During Dengue Virus Infection. Murphy Schafer AR, Smith JL, Pryke KM, DeFilippis VR, Hirsch AJ. Front Microbiol. 2020 Feb 14;11:24. doi: 10.3389/fmicb.2020.00024. eCollection 2020. PubMed |
| Sirt2-associated transcriptome modifications in cisplatin-induced neuronal injury. Zhao X, Du W, Zhang M, Atiq ZO, Xia F. BMC Genomics. 2020 Mar 2;21(1):192. doi: 10.1186/s12864-020-6584-2. PubMed |
| Intratumoral Delivery of a PD-1-Blocking scFv Encoded in Oncolytic HSV-1 Promotes Antitumor Immunity and Synergizes with TIGIT Blockade. Lin C, Ren W, Luo Y, Li S, Chang Y, Li L, Xiong D, Huang X, Xu Z, Yu Z, Wang Y, Zhang J, Huang C, Xia N. Cancer Immunol Res. 2020 May;8(5):632-647. doi: 10.1158/2326-6066.CIR-19-0628. Epub 2020 Mar 3. PubMed |
| SLFN11 Expression in Advanced Prostate Cancer and Response to Platinum-based Chemotherapy. Conteduca V, Ku SY, Puca L, Slade M, Fernandez L, Hess J, Bareja R, Vlachostergios PJ, Sigouros M, Mosquera JM, Sboner A, Nanus DM, Elemento O, Dittamore R, Tagawa ST, Beltran H. Mol Cancer Ther. 2020 May;19(5):1157-1164. doi: 10.1158/1535-7163.MCT-19-0926. Epub 2020 Mar 3. PubMed |
| LATS kinase-mediated CTCF phosphorylation and selective loss of genomic binding. Luo H, Yu Q, Liu Y, Tang M, Liang M, Zhang D, Xiao TS, Wu L, Tan M, Ruan Y, Bungert J, Lu J. Sci Adv. 2020 Feb 19;6(8):eaaw4651. doi: 10.1126/sciadv.aaw4651. eCollection 2020 Feb. PubMed |
| Bacteria Boost Mammalian Host NAD Metabolism by Engaging the Deamidated Biosynthesis Pathway. Shats I, Williams JG, Liu J, Makarov MV, Wu X, Lih FB, Deterding LJ, Lim C, Xu X, Randall TA, Lee E, Li W, Fan W, Li JL, Sokolsky M, Kabanov AV, Li L, Migaud ME, Locasale JW, Li X. Cell Metab. 2020 Mar 3;31(3):564-579.e7. doi: 10.1016/j.cmet.2020.02.001. PubMed |
High-Throughput Screens of PAM-Flexible Cas9 Variants for Gene Knockout and Transcriptional Modulation.
Legut M, Daniloski Z, Xue X, McKenzie D, Guo X, Wessels HH, Sanjana NE.
Cell Rep. 2020 Mar 3;30(9):2859-2868.e5. doi: 10.1016/j.celrep.2020.02.010.
PubMed
Associated Plasmids
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| Early B Cell Factor Activity Controls Developmental and Adaptive Thermogenic Gene Programming in Adipocytes. Angueira AR, Shapira SN, Ishibashi J, Sampat S, Sostre-Colon J, Emmett MJ, Titchenell PM, Lazar MA, Lim HW, Seale P. Cell Rep. 2020 Mar 3;30(9):2869-2878.e4. doi: 10.1016/j.celrep.2020.02.023. PubMed |
| SIRT2 protects peripheral neurons from cisplatin-induced injury by enhancing nucleotide excision repair. Zhang M, Du W, Acklin S, Jin S, Xia F. J Clin Invest. 2020 Jun 1;130(6):2953-2965. doi: 10.1172/JCI123159. PubMed |
| Serine Biosynthesis Pathway Supports MYC-miR-494-EZH2 Feed-Forward Circuit Necessary to Maintain Metabolic and Epigenetic Reprogramming of Burkitt Lymphoma Cells. Bialopiotrowicz E, Noyszewska-Kania M, Kachamakova-Trojanowska N, Loboda A, Cybulska M, Grochowska A, Kopczynski M, Mikula M, Prochorec-Sobieszek M, Firczuk M, Graczyk-Jarzynka A, Zagozdzon R, Zabek A, Mlynarz P, Dulak J, Gorniak P, Szydlowski M, Pyziak K, Martyka J, Sroka-Porada A, Jablonska E, Polak A, Kowalczyk P, Szumera-Cieckiewicz A, Chapuy B, Rzymski T, Brzozka K, Juszczynski P. Cancers (Basel). 2020 Mar 3;12(3). pii: cancers12030580. doi: 10.3390/cancers12030580. PubMed |
| Protocatechuic Aldehyde Represses Proliferation and Migration of Breast Cancer Cells through Targeting C-terminal Binding Protein 1. Deng Y, Guo W, Li G, Li S, Li H, Li X, Niu B, Song M, Zhang Y, Xu Z, Li F. J Breast Cancer. 2020 Jan 3;23(1):20-35. doi: 10.4048/jbc.2020.23.e7. eCollection 2020 Feb. PubMed |
| Modulation of Transient Receptor Potential Channels 3 and 6 Regulates Osteoclast Function with Impact on Trabecular Bone Loss. Klein S, Mentrup B, Timmen M, Sherwood J, Lindemann O, Fobker M, Kronenberg D, Pap T, Raschke MJ, Stange R. Calcif Tissue Int. 2020 Jun;106(6):655-664. doi: 10.1007/s00223-020-00673-8. Epub 2020 Mar 5. PubMed |
| FcRn overexpression in human cancer drives albumin recycling and cell growth; a mechanistic basis for exploitation in targeted albumin-drug designs. Larsen MT, Mandrup OA, Schelde KK, Luo Y, Sorensen KD, Dagnaes-Hansen F, Cameron J, Stougaard M, Steiniche T, Howard KA. J Control Release. 2020 Jun 10;322:53-63. doi: 10.1016/j.jconrel.2020.03.004. Epub 2020 Mar 4. PubMed |
| NMP4 regulates the innate immune response to influenza A virus infection. Yang S, Adaway M, Du J, Huang S, Sun J, Bidwell JP, Zhou B. Mucosal Immunol. 2021 Jan;14(1):209-218. doi: 10.1038/s41385-020-0280-z. Epub 2020 Mar 9. PubMed |
A widespread role for SLC transmembrane transporters in resistance to cytotoxic drugs.
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| Barrier-to-Autointegration Factor 1 Protects against a Basal cGAS-STING Response. Ma H, Qian W, Bambouskova M, Collins PL, Porter SI, Byrum AK, Zhang R, Artyomov M, Oltz EM, Mosammaparast N, Miner JJ, Diamond MS. mBio. 2020 Mar 10;11(2). pii: mBio.00136-20. doi: 10.1128/mBio.00136-20. PubMed |
| Long noncoding RNA pncRNA-D reduces cyclin D1 gene expression and arrests cell cycle through RNA m(6)A modification. Yoneda R, Ueda N, Uranishi K, Hirasaki M, Kurokawa R. J Biol Chem. 2020 Apr 24;295(17):5626-5639. doi: 10.1074/jbc.RA119.011556. Epub 2020 Mar 12. PubMed |
| Amino acid levels determine metabolism and CYP450 function of hepatocytes and hepatoma cell lines. Boon R, Kumar M, Tricot T, Elia I, Ordovas L, Jacobs F, One J, De Smedt J, Eelen G, Bird M, Roelandt P, Doglioni G, Vriens K, Rossi M, Vazquez MA, Vanwelden T, Chesnais F, El Taghdouini A, Najimi M, Sokal E, Cassiman D, Snoeys J, Monshouwer M, Hu WS, Lange C, Carmeliet P, Fendt SM, Verfaillie CM. Nat Commun. 2020 Mar 13;11(1):1393. doi: 10.1038/s41467-020-15058-6. PubMed |
| Proteasome inhibitors and Smac mimetics cooperate to induce cell death in diffuse large B-cell lymphoma by stabilizing NOXA and triggering mitochondrial apoptosis. Dietz A, Dalda N, Zielke S, Dittmann J, van Wijk SJL, Vogler M, Fulda S. Int J Cancer. 2020 Sep 1;147(5):1485-1498. doi: 10.1002/ijc.32976. Epub 2020 Apr 8. PubMed |
| Involvement of caspase-1 in inflammasomes activation and bacterial clearance in S. aureus-infected osteoblast-like MG-63 cells. Lima Leite E, Gautron A, Deplanche M, Nicolas A, Ossemond J, Nguyen MT, do Carmo FLR, Gilot D, Azevedo V, Gotz F, Le Loir Y, Otto M, Berkova N. Cell Microbiol. 2020 Aug;22(8):e13204. doi: 10.1111/cmi.13204. Epub 2020 Apr 6. PubMed |
| Biallelic loss of FAM46C triggers tumor growth with concomitant activation of Akt signaling in multiple myeloma cells. Kanasugi J, Hanamura I, Ota A, Karnan S, Lam VQ, Mizuno S, Wahiduzzaman M, Rahman ML, Hyodo T, Konishi H, Tsuzuki S, Hosokawa Y, Takami A. Cancer Sci. 2020 May;111(5):1663-1675. doi: 10.1111/cas.14386. Epub 2020 Apr 9. PubMed |
| Chromatin accessibility promotes hematopoietic and leukemia stem cell activity. Cabal-Hierro L, van Galen P, Prado MA, Higby KJ, Togami K, Mowery CT, Paulo JA, Xie Y, Cejas P, Furusawa T, Bustin M, Long HW, Sykes DB, Gygi SP, Finley D, Bernstein BE, Lane AA. Nat Commun. 2020 Mar 16;11(1):1406. doi: 10.1038/s41467-020-15221-z. PubMed |
| Localized cocktail chemoimmunotherapy after in situ gelation to trigger robust systemic antitumor immune responses. Chao Y, Liang C, Tao H, Du Y, Wu D, Dong Z, Jin Q, Chen G, Xu J, Xiao Z, Chen Q, Wang C, Chen J, Liu Z. Sci Adv. 2020 Mar 4;6(10):eaaz4204. doi: 10.1126/sciadv.aaz4204. eCollection 2020 Mar. PubMed |
| ADORA1 Inhibition Promotes Tumor Immune Evasion by Regulating the ATF3-PD-L1 Axis. Liu H, Kuang X, Zhang Y, Ye Y, Li J, Liang L, Xie Z, Weng L, Guo J, Li H, Ma F, Chen X, Zhao S, Su J, Yang N, Fang F, Xie Y, Tao J, Zhang J, Chen M, Peng C, Sun L, Zhang X, Liu J, Han L, Xu X, Hung MC, Chen X. Cancer Cell. 2020 Mar 16;37(3):324-339.e8. doi: 10.1016/j.ccell.2020.02.006. PubMed |
| A new selective pharmacological enhancer of the Orai1 Ca(2+) channel reveals roles for Orai1 in smooth and skeletal muscle functions. Azimi I, Stevenson RJ, Zhang X, Meizoso-Huesca A, Xin P, Johnson M, Flanagan JU, Chalmers SB, Yoast RE, Kapure JS, Ross BP, Vetter I, Ashton MR, Launikonis BS, Denny WA, Trebak M, Monteith GR. ACS Pharmacol Transl Sci. 2020 Feb 14;3(1):135-147. doi: 10.1021/acsptsci.9b00081. Epub 2020 Jan 13. PubMed |
| Coronavirus endoribonuclease targets viral polyuridine sequences to evade activating host sensors. Hackbart M, Deng X, Baker SC. Proc Natl Acad Sci U S A. 2020 Apr 7;117(14):8094-8103. doi: 10.1073/pnas.1921485117. Epub 2020 Mar 20. PubMed |
| Cyclin B1 scaffolds MAD1 at the kinetochore corona to activate the mitotic checkpoint. Allan LA, Camacho Reis M, Ciossani G, Huis In 't Veld PJ, Wohlgemuth S, Kops GJ, Musacchio A, Saurin AT. EMBO J. 2020 Jun 17;39(12):e103180. doi: 10.15252/embj.2019103180. Epub 2020 Mar 23. PubMed |
| Copper is an essential regulator of the autophagic kinases ULK1/2 to drive lung adenocarcinoma. Tsang T, Posimo JM, Gudiel AA, Cicchini M, Feldser DM, Brady DC. Nat Cell Biol. 2020 Apr;22(4):412-424. doi: 10.1038/s41556-020-0481-4. Epub 2020 Mar 16. PubMed |
| Using antagonistic pleiotropy to design a chemotherapy-induced evolutionary trap to target drug resistance in cancer. Lin KH, Rutter JC, Xie A, Pardieu B, Winn ET, Bello RD, Forget A, Itzykson R, Ahn YR, Dai Z, Sobhan RT, Anderson GR, Singleton KR, Decker AE, Winter PS, Locasale JW, Crawford L, Puissant A, Wood KC. Nat Genet. 2020 Apr;52(4):408-417. doi: 10.1038/s41588-020-0590-9. Epub 2020 Mar 16. PubMed |
| Dominant-negative mutations in human IL6ST underlie hyper-IgE syndrome. Beziat V, Tavernier SJ, Chen YH, Ma CS, Materna M, Laurence A, Staal J, Aschenbrenner D, Roels L, Worley L, Claes K, Gartner L, Kohn LA, De Bruyne M, Schmitz-Abe K, Charbonnier LM, Keles S, Nammour J, Vladikine N, Maglorius Renkilaraj MRL, Seeleuthner Y, Migaud M, Rosain J, Jeljeli M, Boisson B, Van Braeckel E, Rosenfeld JA, Dai H, Burrage LC, Murdock DR, Lambrecht BN, Avettand-Fenoel V, Vogel TP, Esther CR, Haskologlu S, Dogu F, Ciznar P, Boutboul D, Ouachee-Chardin M, Amourette J, Lebras MN, Gauvain C, Tcherakian C, Ikinciogullari A, Beyaert R, Abel L, Milner JD, Grimbacher B, Couderc LJ, Butte MJ, Freeman AF, Catherinot E, Fieschi C, Chatila TA, Tangye SG, Uhlig HH, Haerynck F, Casanova JL, Puel A. J Exp Med. 2020 Jun 1;217(6). pii: 151577. doi: 10.1084/jem.20191804. PubMed |
| Phosphorylated Lamin A/C in the Nuclear Interior Binds Active Enhancers Associated with Abnormal Transcription in Progeria. Ikegami K, Secchia S, Almakki O, Lieb JD, Moskowitz IP. Dev Cell. 2020 Mar 23;52(6):699-713.e11. doi: 10.1016/j.devcel.2020.02.011. PubMed |
| Generation of Genetically Engineered Mouse Lung Organoid Models for Squamous Cell Lung Cancers Allows for the Study of Combinatorial Immunotherapy. Hai J, Zhang H, Zhou J, Wu Z, Chen T, Papadopoulos E, Dowling CM, Pyon V, Pan Y, Liu JB, Bronson RT, Silver H, Lizotte PH, Deng J, Campbell JD, Sholl LM, Ng C, Tsao MS, Thakurdin C, Bass AJ, Wong KK. Clin Cancer Res. 2020 Jul 1;26(13):3431-3442. doi: 10.1158/1078-0432.CCR-19-1627. Epub 2020 Mar 24. PubMed |
| CRISPR-based gene knockout screens reveal deubiquitinases involved in HIV-1 latency in two Jurkat cell models. Rathore A, Iketani S, Wang P, Jia M, Sahi V, Ho DD. Sci Rep. 2020 Mar 24;10(1):5350. doi: 10.1038/s41598-020-62375-3. PubMed |
| CD20 is dispensable for B-cell receptor signaling but is required for proper actin polymerization, adhesion and migration of malignant B cells. Kozlova V, Ledererova A, Ladungova A, Peschelova H, Janovska P, Slusarczyk A, Domagala J, Kopcil P, Vakulova V, Oppelt J, Bryja V, Doubek M, Mayer J, Pospisilova S, Smida M. PLoS One. 2020 Mar 25;15(3):e0229170. doi: 10.1371/journal.pone.0229170. eCollection 2020. PubMed |
| Dengue Virus Serotype 2 and Its Non-Structural Proteins 2A and 2B Activate NLRP3 Inflammasome. Shrivastava G, Visoso-Carvajal G, Garcia-Cordero J, Leon-Juarez M, Chavez-Munguia B, Lopez T, Nava P, Villegas-Sepulveda N, Cedillo-Barron L. Front Immunol. 2020 Mar 10;11:352. doi: 10.3389/fimmu.2020.00352. eCollection 2020. PubMed |
| Applying genome-wide CRISPR-Cas9 screens for therapeutic discovery in facioscapulohumeral muscular dystrophy. Lek A, Zhang Y, Woodman KG, Huang S, DeSimone AM, Cohen J, Ho V, Conner J, Mead L, Kodani A, Pakula A, Sanjana N, King OD, Jones PL, Wagner KR, Lek M, Kunkel LM. Sci Transl Med. 2020 Mar 25;12(536). pii: 12/536/eaay0271. doi: 10.1126/scitranslmed.aay0271. PubMed |
| A20 Restricts Inflammatory Response and Desensitizes Gingival Keratinocytes to Apoptosis. Li Y, Mooney EC, Xia XJ, Gupta N, Sahingur SE. Front Immunol. 2020 Mar 10;11:365. doi: 10.3389/fimmu.2020.00365. eCollection 2020. PubMed |
| Identification of primordial germ cell-like cells as liver metastasis initiating cells in mouse tumour models. Liu C, Ma Z, Cai Z, Zhang F, Liu C, Chen T, Peng D, Xu X, Lin HK. Cell Discov. 2020 Mar 24;6:15. doi: 10.1038/s41421-020-0145-3. eCollection 2020. PubMed |
| CIC is a critical regulator of neuronal differentiation. Hwang I, Pan H, Yao J, Elemento O, Zheng H, Paik J. JCI Insight. 2020 May 7;5(9). pii: 135826. doi: 10.1172/jci.insight.135826. PubMed |
| EDN1-AS, A Novel Long Non-coding RNA Regulating Endothelin-1 in Human Proximal Tubule Cells. Douma LG, Solocinski K, Masten SH, Barral DH, Barilovits SJ, Jeffers LA, Alder KD, Patel R, Wingo CS, Brown KD, Cain BD, Gumz ML. Front Physiol. 2020 Mar 13;11:209. doi: 10.3389/fphys.2020.00209. eCollection 2020. PubMed |
| PLCE1 regulates the migration, proliferation, and differentiation of podocytes. Yu S, Choi WI, Choi YJ, Kim HY, Hildebrandt F, Gee HY. Exp Mol Med. 2020 Apr;52(4):594-603. doi: 10.1038/s12276-020-0410-4. Epub 2020 Apr 1. PubMed |
| Mitochondrial DNA mutations induce mitochondrial biogenesis and increase the tumorigenic potential of Hodgkin and Reed-Sternberg cells. Haumann S, Boix J, Knuever J, Bieling A, Vila Sanjurjo A, Elson JL, Blakely EL, Taylor RW, Riet N, Abken H, Kashkar H, Hornig-Do HT, Wiesner RJ. Carcinogenesis. 2020 Apr 7. pii: 5817053. doi: 10.1093/carcin/bgaa032. PubMed |
| Distinct Roles of TRAPPC8 and TRAPPC12 in Ciliogenesis via Their Interactions With OFD1. Zhang C, Li C, Siu GKY, Luo X, Yu S. Front Cell Dev Biol. 2020 Mar 17;8:148. doi: 10.3389/fcell.2020.00148. eCollection 2020. PubMed |
| MST4 kinase suppresses gastric tumorigenesis by limiting YAP activation via a non-canonical pathway. An L, Nie P, Chen M, Tang Y, Zhang H, Guan J, Cao Z, Hou C, Wang W, Zhao Y, Xu H, Jiao S, Zhou Z. J Exp Med. 2020 Jun 1;217(6). pii: 151647. doi: 10.1084/jem.20191817. PubMed |
| Transfer of cGAMP into Bystander Cells via LRRC8 Volume-Regulated Anion Channels Augments STING-Mediated Interferon Responses and Anti-viral Immunity. Zhou C, Chen X, Planells-Cases R, Chu J, Wang L, Cao L, Li Z, Lopez-Cayuqueo KI, Xie Y, Ye S, Wang X, Ullrich F, Ma S, Fang Y, Zhang X, Qian Z, Liang X, Cai SQ, Jiang Z, Zhou D, Leng Q, Xiao TS, Lan K, Yang J, Li H, Peng C, Qiu Z, Jentsch TJ, Xiao H. Immunity. 2020 May 19;52(5):767-781.e6. doi: 10.1016/j.immuni.2020.03.016. Epub 2020 Apr 10. PubMed |
| TRIM34 restricts HIV-1 and SIV capsids in a TRIM5alpha-dependent manner. Ohainle M, Kim K, Komurlu Keceli S, Felton A, Campbell E, Luban J, Emerman M. PLoS Pathog. 2020 Apr 13;16(4):e1008507. doi: 10.1371/journal.ppat.1008507. eCollection 2020 Apr. PubMed |
| Targeting the scaffolding role of LSD1 (KDM1A) poises acute myeloid leukemia cells for retinoic acid-induced differentiation. Ravasio R, Ceccacci E, Nicosia L, Hosseini A, Rossi PL, Barozzi I, Fornasari L, Zuffo RD, Valente S, Fioravanti R, Mercurio C, Varasi M, Mattevi A, Mai A, Pavesi G, Bonaldi T, Minucci S. Sci Adv. 2020 Apr 8;6(15):eaax2746. doi: 10.1126/sciadv.aax2746. eCollection 2020 Apr. PubMed |
| Dietary lipids fuel GPX4-restricted enteritis resembling Crohn's disease. Mayr L, Grabherr F, Schwarzler J, Reitmeier I, Sommer F, Gehmacher T, Niederreiter L, He GW, Ruder B, Kunz KTR, Tymoszuk P, Hilbe R, Haschka D, Feistritzer C, Gerner RR, Enrich B, Przysiecki N, Seifert M, Keller MA, Oberhuber G, Sprung S, Ran Q, Koch R, Effenberger M, Tancevski I, Zoller H, Moschen AR, Weiss G, Becker C, Rosenstiel P, Kaser A, Tilg H, Adolph TE. Nat Commun. 2020 Apr 14;11(1):1775. doi: 10.1038/s41467-020-15646-6. PubMed |
| Inhibition of CDK9 by voruciclib synergistically enhances cell death induced by the Bcl-2 selective inhibitor venetoclax in preclinical models of acute myeloid leukemia. Luedtke DA, Su Y, Ma J, Li X, Buck SA, Edwards H, Polin L, Kushner J, Dzinic SH, White K, Lin H, Taub JW, Ge Y. Signal Transduct Target Ther. 2020 Feb 26;5(1):17. doi: 10.1038/s41392-020-0112-3. PubMed |
| Sprouty1 Prevents Cellular Senescence Maintaining Proliferation and Differentiation Capacity of Human Adipose Stem/Progenitor Cells. Mandl M, Wagner SA, Hatzmann FM, Ejaz A, Ritthammer H, Baumgarten S, Viertler HP, Springer J, Zwierzina ME, Mattesich O, Waldegger P, Pierer G, Zwerschke W. J Gerontol A Biol Sci Med Sci. 2020 Apr 18. pii: 5822045. doi: 10.1093/gerona/glaa098. PubMed |
| AP1S1 missense mutations cause a congenital enteropathy via an epithelial barrier defect. Klee KMC, Janecke AR, Civan HA, Rosipal S, Heinz-Erian P, Huber LA, Muller T, Vogel GF. Hum Genet. 2020 Apr 18. pii: 10.1007/s00439-020-02168-w. doi: 10.1007/s00439-020-02168-w. PubMed |
| HMCES safeguards replication from oxidative stress and ensures error-free repair. Srivastava M, Su D, Zhang H, Chen Z, Tang M, Nie L, Chen J. EMBO Rep. 2020 Jun 4;21(6):e49123. doi: 10.15252/embr.201949123. Epub 2020 Apr 19. PubMed |
| Selective targeting of the oncogenic KRAS G12S mutant allele by CRISPR/Cas9 induces efficient tumor regression. Gao Q, Ouyang W, Kang B, Han X, Xiong Y, Ding R, Li Y, Wang F, Huang L, Chen L, Wang D, Dong X, Zhang Z, Li Y, Ze B, Hou Y, Yang H, Ma Y, Gu Y, Chao CC. Theranostics. 2020 Apr 6;10(11):5137-5153. doi: 10.7150/thno.42325. eCollection 2020. PubMed |
| Optimization of canine CD20 chimeric antigen receptor T cell manufacturing and in vitro cytotoxic activity against B-cell lymphoma. Sakai O, Igase M, Mizuno T. Vet Comp Oncol. 2020 Apr 23. doi: 10.1111/vco.12602. PubMed |
| Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity. He Y, Zhang X, Chang J, Kim HN, Zhang P, Wang Y, Khan S, Liu X, Zhang X, Lv D, Song L, Li W, Thummuri D, Yuan Y, Wiegand JS, Ortiz YT, Budamagunta V, Elisseeff JH, Campisi J, Almeida M, Zheng G, Zhou D. Nat Commun. 2020 Apr 24;11(1):1996. doi: 10.1038/s41467-020-15838-0. PubMed |
| DNA Methylation Regulates Alternative Polyadenylation via CTCF and the Cohesin Complex. Nanavaty V, Abrash EW, Hong C, Park S, Fink EE, Li Z, Sweet TJ, Bhasin JM, Singuri S, Lee BH, Hwang TH, Ting AH. Mol Cell. 2020 May 21;78(4):752-764.e6. doi: 10.1016/j.molcel.2020.03.024. Epub 2020 Apr 24. PubMed |
| Sec22b determines Weibel-Palade body length by controlling anterograde ER-Golgi transport. Karampini E, Burgisser PE, Olins J, Mulder AA, Jost CR, Geerts D, Voorberg J, Bierings R. Haematologica. 2020 Mar 26. pii: haematol.2019.242727. doi: 10.3324/haematol.2019.242727. PubMed |
| EX VIVO IKKbeta ABLATION RESCUES THE IMMUNOPOTENCY OF MESENCHYMAL STROMAL CELLS FROM DIABETICS WITH ADVANCED ATHEROSCLEROSIS. Mancini OK, Huynh DN, Menard L, Shum-Tim D, Ong H, Marleau S, Colmegna I, Servant MJ. Cardiovasc Res. 2020 Apr 27. pii: 5825728. doi: 10.1093/cvr/cvaa118. PubMed |
Selective alanine transporter utilization creates a targetable metabolic niche in pancreatic cancer.
Parker SJ, Amendola CR, Hollinshead KER, Yu Q, Yamamoto K, Encarnacion-Rosado J, Rose RE, LaRue MM, Sohn ASW, Biancur DE, Paulo JA, Gygi SP, Jones DR, Wang H, Philips MR, Bar-Sagi D, Mancias JD, Kimmelman AC.
Cancer Discov. 2020 Apr 27. pii: 2159-8290.CD-19-0959. doi: 10.1158/2159-8290.CD-19-0959.
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| Unique Role of Histone Methyltransferase PRDM8 in the Tumorigenesis of Virus-Negative Merkel Cell Carcinoma. Orouji E, Peitsch WK, Orouji A, Houben R, Utikal J. Cancers (Basel). 2020 Apr 24;12(4). pii: cancers12041057. doi: 10.3390/cancers12041057. PubMed |
| B7-H3-Targeted CAR-T Cells Exhibit Potent Antitumor Effects on Hematologic and Solid Tumors. Zhang Z, Jiang C, Liu Z, Yang M, Tang X, Wang Y, Zheng M, Huang J, Zhong K, Zhao S, Tang M, Zhou T, Yang H, Guo G, Zhou L, Xu J, Tong A. Mol Ther Oncolytics. 2020 Apr 7;17:180-189. doi: 10.1016/j.omto.2020.03.019. eCollection 2020 Jun 26. PubMed |
| Lactation improves pancreatic beta cell mass and function through serotonin production. Moon JH, Kim H, Kim H, Park J, Choi W, Choi W, Hong HJ, Ro HJ, Jun S, Choi SH, Banerjee RR, Shong M, Cho NH, Kim SK, German MS, Jang HC, Kim H. Sci Transl Med. 2020 Apr 29;12(541). pii: 12/541/eaay0455. doi: 10.1126/scitranslmed.aay0455. PubMed |
| lncRNA Neat1 Stimulates Osteoclastogenesis Via Sponging miR-7. Zhang Y, Chen XF, Li J, He F, Li X, Guo Y. J Bone Miner Res. 2020 Apr 30. doi: 10.1002/jbmr.4039. PubMed |
| Ubiquitination of the DNA-damage checkpoint kinase CHK1 by TRAF4 is required for CHK1 activation. Yu X, Li W, Liu H, Deng Q, Wang X, Hu H, Xu-Monette ZY, Xiong W, Lu Z, Young KH, Wang W, Li Y. J Hematol Oncol. 2020 May 1;13(1):40. doi: 10.1186/s13045-020-00869-3. PubMed |
| TRAF3IP3 negatively regulates cytosolic RNA induced anti-viral signaling by promoting TBK1 K48 ubiquitination. Deng M, Tam JW, Wang L, Liang K, Li S, Zhang L, Guo H, Luo X, Zhang Y, Petrucelli A, Davis BK, Conti BJ, June Brickey W, Ko CC, Lei YL, Sun S, Ting JP. Nat Commun. 2020 May 4;11(1):2193. doi: 10.1038/s41467-020-16014-0. PubMed |
| Formate induces a metabolic switch in nucleotide and energy metabolism. Oizel K, Tait-Mulder J, Fernandez-de-Cossio-Diaz J, Pietzke M, Brunton H, Lilla S, Dhayade S, Athineos D, Blanco GR, Sumpton D, Mackay GM, Blyth K, Zanivan SR, Meiser J, Vazquez A. Cell Death Dis. 2020 May 4;11(5):310. doi: 10.1038/s41419-020-2523-z. PubMed |
| Epithelial cell -derived microvesicles: A safe delivery platform of CRISPR/Cas9 conferring synergistic anti-tumor effect with sorafenib. He C, Jaffar Ali D, Xu H, Kumaravel S, Si K, Li Y, Sun B, Ma J, Xiao Z. Exp Cell Res. 2020 Jul 15;392(2):112040. doi: 10.1016/j.yexcr.2020.112040. Epub 2020 May 4. PubMed |
| Porcine DNAJB6 promotes PCV2 replication via enhancing the formation of autophagy in host cells. Han C, Du Q, Zhu L, Chen N, Luo L, Chen Q, Yin J, Wu X, Tong D, Huang Y. Vet Res. 2020 May 7;51(1):61. doi: 10.1186/s13567-020-00783-z. PubMed |
| ADCK4 Deficiency Destabilizes the Coenzyme Q Complex, Which Is Rescued by 2,4-Dihydroxybenzoic Acid Treatment. Widmeier E, Yu S, Nag A, Chung YW, Nakayama M, Fernandez-Del-Rio L, Hugo H, Schapiro D, Buerger F, Choi WI, Helmstadter M, Kim JW, Ryu JH, Lee MG, Clarke CF, Hildebrandt F, Gee HY. J Am Soc Nephrol. 2020 Jun;31(6):1191-1211. doi: 10.1681/ASN.2019070756. Epub 2020 May 7. PubMed |
Regulation of mRNA export through API5 and nuclear FGF2 interaction.
Bong SM, Bae SH, Song B, Gwak H, Yang SW, Kim S, Nam S, Rajalingam K, Oh SJ, Kim TW, Park S, Jang H, Lee BI.
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| p62 is Negatively Implicated in the TRAF6-BECN1 Signaling Axis for Autophagy Activation and Cancer Progression by Toll-Like Receptor 4 (TLR4). Kim MJ, Min Y, Im JS, Son J, Lee JS, Lee KY. Cells. 2020 May 6;9(5). pii: cells9051142. doi: 10.3390/cells9051142. PubMed |
| Linker histone H1.2 and H1.4 affect the neutrophil lineage determination. Sollberger G, Streeck R, Apel F, Caffrey BE, Skoultchi AI, Zychlinsky A. Elife. 2020 May 11;9. pii: 52563. doi: 10.7554/eLife.52563. PubMed |
| A small molecule G6PD inhibitor reveals immune dependence on pentose phosphate pathway. Ghergurovich JM, Garcia-Canaveras JC, Wang J, Schmidt E, Zhang Z, TeSlaa T, Patel H, Chen L, Britt EC, Piqueras-Nebot M, Gomez-Cabrera MC, Lahoz A, Fan J, Beier UH, Kim H, Rabinowitz JD. Nat Chem Biol. 2020 Jul;16(7):731-739. doi: 10.1038/s41589-020-0533-x. Epub 2020 May 11. PubMed |
| Dynamic landscape and evolution of m6A methylation in human. Zhang H, Shi X, Huang T, Zhao X, Chen W, Gu N, Zhang R. Nucleic Acids Res. 2020 Jun 19;48(11):6251-6264. doi: 10.1093/nar/gkaa347. PubMed |
| Amelioration of an Inherited Metabolic Liver Disease through Creation of a De Novo Start Codon by Cytidine Base Editing. Yang L, Wang L, Huo Y, Chen X, Yin S, Hu Y, Zhang X, Zheng R, Geng H, Han H, Ma X, Liu M, Li H, Yu W, Liu M, Wang J, Li D. Mol Ther. 2020 Jul 8;28(7):1673-1683. doi: 10.1016/j.ymthe.2020.05.001. Epub 2020 May 7. PubMed |
| The native ORAI channel trio underlies the diversity of Ca(2+) signaling events. Yoast RE, Emrich SM, Zhang X, Xin P, Johnson MT, Fike AJ, Walter V, Hempel N, Yule DI, Sneyd J, Gill DL, Trebak M. Nat Commun. 2020 May 15;11(1):2444. doi: 10.1038/s41467-020-16232-6. PubMed |
| Accumulation of AGO2 Facilitates Tumorigenesis of Human Hepatocellular Carcinoma. Yang Y, Mei Q. Biomed Res Int. 2020 Apr 30;2020:1631843. doi: 10.1155/2020/1631843. eCollection 2020. PubMed |
| Contribution of HDAC3 to transcriptional repression by the human papillomavirus 31 E8^E2 protein. Dreer M, Blondzik S, Straub E, Iftner T, Stubenrauch F. J Gen Virol. 2020 Jul;101(7):751-759. doi: 10.1099/jgv.0.001438. PubMed |
| Sense-antisense miRNA pairs constitute an elaborate reciprocal regulatory circuit. Song Y, Li L, Yang W, Fu Q, Chen W, Fang Z, Li W, Gu N, Zhang R. Genome Res. 2020 May;30(5):661-672. doi: 10.1101/gr.257121.119. Epub 2020 May 18. PubMed |
| Unpredicted central inversion in a sgRNA flanked by inverted repeats. Wang G, Sukumar S. Mol Biol Rep. 2020 Aug;47(8):6375-6378. doi: 10.1007/s11033-020-05524-1. Epub 2020 May 18. PubMed |
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| Pathway-Specific Genome Editing of PI3K/mTOR Tumor Suppressor Genes Reveals that PTEN Loss Contributes to Cetuximab Resistance in Head and Neck Cancer. Izumi H, Wang Z, Goto Y, Ando T, Wu X, Zhang X, Li H, Johnson DE, Grandis JR, Gutkind JS. Mol Cancer Ther. 2020 Jul;19(7):1562-1571. doi: 10.1158/1535-7163.MCT-19-1036. Epub 2020 May 19. PubMed |
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| hGBP1 Coordinates Chlamydia Restriction and Inflammasome Activation through Sequential GTP Hydrolysis. Xavier A, Al-Zeer MA, Meyer TF, Daumke O. Cell Rep. 2020 May 19;31(7):107667. doi: 10.1016/j.celrep.2020.107667. PubMed |
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| Generation of hepatocyte-like cells from human urinary epithelial cells and the role of autophagy during direct reprogramming. Wu H, Du C, Yang F, Zheng X, Qiu D, Zhang Q, Chen W, Xu Y. Biochem Biophys Res Commun. 2020 Jun 30;527(3):723-729. doi: 10.1016/j.bbrc.2020.03.119. Epub 2020 May 18. PubMed |
| Hesperetin inhibit EMT in TGF-beta treated podocyte by regulation of mTOR pathway. Choi D, Kim CL, Kim JE, Mo JS, Jeong HS. Biochem Biophys Res Commun. 2020 Jul 12;528(1):154-159. doi: 10.1016/j.bbrc.2020.05.087. Epub 2020 May 22. PubMed |
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| Noncoding Y RNAs regulate the levels, subcellular distribution and protein interactions of their Ro60 autoantigen partner. Leng Y, Sim S, Magidson V, Wolin SL. Nucleic Acids Res. 2020 Jul 9;48(12):6919-6930. doi: 10.1093/nar/gkaa414. PubMed |
| MAX Functions as a Tumor Suppressor and Rewires Metabolism in Small Cell Lung Cancer. Augert A, Mathsyaraja H, Ibrahim AH, Freie B, Geuenich MJ, Cheng PF, Alibeckoff SP, Wu N, Hiatt JB, Basom R, Gazdar A, Sullivan LB, Eisenman RN, MacPherson D. Cancer Cell. 2020 Jul 13;38(1):97-114.e7. doi: 10.1016/j.ccell.2020.04.016. Epub 2020 May 28. PubMed |
| Novel role of PAF1 in attenuating radiosensitivity in cervical cancer by inhibiting IER5 transcription. Zheng JJ, He Y, Liu Y, Li FS, Cui Z, Du XM, Wang CP, Wu YM. Radiat Oncol. 2020 May 29;15(1):131. doi: 10.1186/s13014-020-01580-w. PubMed |
| Protein phosphatase 1 regulatory subunit 1A regulates cell cycle progression in Ewing sarcoma. Luo W, Xu C, Phillips S, Gardenswartz A, Rosenblum JM, Ayello J, Lessnick SL, Hao HX, Cairo MS. Oncotarget. 2020 May 12;11(19):1691-1704. doi: 10.18632/oncotarget.27571. eCollection 2020 May 12. PubMed |
| Multiple Functions of Fubp1 in Cell Cycle Progression and Cell Survival. Kang M, Kim HJ, Kim TJ, Byun JS, Lee JH, Lee DH, Kim W, Kim DY. Cells. 2020 May 28;9(6). pii: cells9061347. doi: 10.3390/cells9061347. PubMed |
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Dual base editor catalyzes both cytosine and adenine base conversions in human cells.
Zhang X, Zhu B, Chen L, Xie L, Yu W, Wang Y, Li L, Yin S, Yang L, Hu H, Han H, Li Y, Wang L, Chen G, Ma X, Geng H, Huang W, Pang X, Yang Z, Wu Y, Siwko S, Kurita R, Nakamura Y, Yang L, Liu M, Li D.
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| ABL Genomic Editing Sufficiently Abolishes Oncogenesis of Human Chronic Myeloid Leukemia Cells In Vitro and In Vivo. Chen SH, Hsieh YY, Tzeng HE, Lin CY, Hsu KW, Chiang YS, Lin SM, Su MJ, Hsieh WS, Lee CH. Cancers (Basel). 2020 May 29;12(6). pii: cancers12061399. doi: 10.3390/cancers12061399. PubMed |
| ERK-Mediated Mechanochemical Waves Direct Collective Cell Polarization. Hino N, Rossetti L, Marin-Llaurado A, Aoki K, Trepat X, Matsuda M, Hirashima T. Dev Cell. 2020 Jun 22;53(6):646-660.e8. doi: 10.1016/j.devcel.2020.05.011. Epub 2020 Jun 3. PubMed |
| Three-dimensional bioprinted glioblastoma microenvironments model cellular dependencies and immune interactions. Tang M, Xie Q, Gimple RC, Zhong Z, Tam T, Tian J, Kidwell RL, Wu Q, Prager BC, Qiu Z, Yu A, Zhu Z, Mesci P, Jing H, Schimelman J, Wang P, Lee D, Lorenzini MH, Dixit D, Zhao L, Bhargava S, Miller TE, Wan X, Tang J, Sun B, Cravatt BF, Muotri AR, Chen S, Rich JN. Cell Res. 2020 Jun 4. pii: 10.1038/s41422-020-0338-1. doi: 10.1038/s41422-020-0338-1. PubMed |
| SAFB2 Enables the Processing of Suboptimal Stem-Loop Structures in Clustered Primary miRNA Transcripts. Hutter K, Lohmuller M, Jukic A, Eichin F, Avci S, Labi V, Szabo TG, Hoser SM, Huttenhofer A, Villunger A, Herzog S. Mol Cell. 2020 Jun 4;78(5):876-889.e6. doi: 10.1016/j.molcel.2020.05.011. PubMed |
| SIRT7 antagonizes human stem cell aging as a heterochromatin stabilizer. Bi S, Liu Z, Wu Z, Wang Z, Liu X, Wang S, Ren J, Yao Y, Zhang W, Song M, Liu GH, Qu J. Protein Cell. 2020 Jul;11(7):483-504. doi: 10.1007/s13238-020-00728-4. Epub 2020 Jun 6. PubMed |
| Endogenous DNA 3' Blocks Are Vulnerabilities for BRCA1 and BRCA2 Deficiency and Are Reversed by the APE2 Nuclease. Alvarez-Quilon A, Wojtaszek JL, Mathieu MC, Patel T, Appel CD, Hustedt N, Rossi SE, Wallace BD, Setiaputra D, Adam S, Ohashi Y, Melo H, Cho T, Gervais C, Munoz IM, Grazzini E, Young JTF, Rouse J, Zinda M, Williams RS, Durocher D. Mol Cell. 2020 Jun 18;78(6):1152-1165.e8. doi: 10.1016/j.molcel.2020.05.021. Epub 2020 Jun 8. PubMed |
Massively parallel Cas13 screens reveal principles for guide RNA design.
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Nat Biotechnol. 2020 Jun;38(6):722-727. doi: 10.1038/s41587-020-0456-9. Epub 2020 Mar 16.
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| The Tumour Suppressor TMEM127 Is a Nedd4-Family E3 Ligase Adaptor Required by Salmonella SteD to Ubiquitinate and Degrade MHC Class II Molecules. Alix E, Godlee C, Cerny O, Blundell S, Tocci R, Matthews S, Liu M, Pruneda JN, Swatek KN, Komander D, Sleap T, Holden DW. Cell Host Microbe. 2020 Jul 8;28(1):54-68.e7. doi: 10.1016/j.chom.2020.04.024. Epub 2020 Jun 10. PubMed |
| Comprehensive Bioinformatics Identifies Key microRNA Players in ATG7-Deficient Lung Fibroblasts. Stojanovic SD, Fuchs M, Fiedler J, Xiao K, Meinecke A, Just A, Pich A, Thum T, Kunz M. Int J Mol Sci. 2020 Jun 9;21(11). pii: ijms21114126. doi: 10.3390/ijms21114126. PubMed |
| Epigenomes of Human Hearts Reveal New Genetic Variants Relevant for Cardiac Disease and Phenotype. Tan WLW, Anene-Nzelu CG, Wong E, Lee CJM, Tan HS, Tang SJ, Perrin A, Wu KX, Zheng W, Ashburn RJ, Pan B, Lee MY, Autio MI, Morley MP, Tam WL, Cheung C, Margulies KB, Chen L, Cappola TP, Loh M, Chambers J, Prabhakar S, Foo RSY. Circ Res. 2020 Aug 28;127(6):761-777. doi: 10.1161/CIRCRESAHA.120.317254. Epub 2020 Jun 12. PubMed |
| The Anticoagulant Nafamostat Potently Inhibits SARS-CoV-2 S Protein-Mediated Fusion in a Cell Fusion Assay System and Viral Infection In Vitro in a Cell-Type-Dependent Manner. Yamamoto M, Kiso M, Sakai-Tagawa Y, Iwatsuki-Horimoto K, Imai M, Takeda M, Kinoshita N, Ohmagari N, Gohda J, Semba K, Matsuda Z, Kawaguchi Y, Kawaoka Y, Inoue JI. Viruses. 2020 Jun 10;12(6). pii: v12060629. doi: 10.3390/v12060629. PubMed |
| Acetylation of Cytidine Residues Boosts HIV-1 Gene Expression by Increasing Viral RNA Stability. Tsai K, Jaguva Vasudevan AA, Martinez Campos C, Emery A, Swanstrom R, Cullen BR. Cell Host Microbe. 2020 Aug 12;28(2):306-312.e6. doi: 10.1016/j.chom.2020.05.011. Epub 2020 Jun 12. PubMed |
| Hepatitis C virus exploits cyclophilin A to evade PKR. Colpitts CC, Ridewood S, Schneiderman B, Warne J, Tabata K, Ng CF, Bartenschlager R, Selwood DL, Towers GJ. Elife. 2020 Jun 16;9. pii: 52237. doi: 10.7554/eLife.52237. PubMed |
| Sequential CRISPR-Based Screens Identify LITAF and CDIP1 as the Bacillus cereus Hemolysin BL Toxin Host Receptors. Liu J, Zuo Z, Sastalla I, Liu C, Jang JY, Sekine Y, Li Y, Pirooznia M, Leppla SH, Finkel T, Liu S. Cell Host Microbe. 2020 Sep 9;28(3):402-410.e5. doi: 10.1016/j.chom.2020.05.012. Epub 2020 Jun 15. PubMed |
| Persistent Innate Immune Stimulation Results in IRF3-Mediated but Caspase-Independent Cytostasis. Urban C, Welsch H, Heine K, Wust S, Haas DA, Dachert C, Pandey A, Pichlmair A, Binder M. Viruses. 2020 Jun 11;12(6). pii: v12060635. doi: 10.3390/v12060635. PubMed |
| The RAS-interacting chaperone UNC119 drives the RASSF6-MDM2-p53 axis and antagonizes RAS-mediated malignant transformation. Shimizu T, Nakamura T, Inaba H, Iwasa H, Maruyama J, Arimoto-Matsuzaki K, Nakata T, Nishina H, Hata Y. J Biol Chem. 2020 Aug 7;295(32):11214-11230. doi: 10.1074/jbc.RA120.012649. Epub 2020 Jun 18. PubMed |
| Genomic deregulation of PRMT5 supports growth and stress tolerance in chronic lymphocytic leukemia. Schnormeier AK, Pommerenke C, Kaufmann M, Drexler HG, Koeppel M. Sci Rep. 2020 Jun 17;10(1):9775. doi: 10.1038/s41598-020-66224-1. PubMed |
| Metabolic Fingerprinting Links Oncogenic PIK3CA with Enhanced Arachidonic Acid-Derived Eicosanoids. Koundouros N, Karali E, Tripp A, Valle A, Inglese P, Perry NJS, Magee DJ, Anjomani Virmouni S, Elder GA, Tyson AL, Doria ML, van Weverwijk A, Soares RF, Isacke CM, Nicholson JK, Glen RC, Takats Z, Poulogiannis G. Cell. 2020 Jun 25;181(7):1596-1611.e27. doi: 10.1016/j.cell.2020.05.053. Epub 2020 Jun 18. PubMed |
| PDGFRbeta plays an essential role in patient vitreous-stimulated contraction of retinal pigment epithelial cells from epiretinal membranes. Yang Y, Huang X, Ma G, Cui J, Matsubara JA, Kazlauskas A, Zhao J, Wang J, Lei H. Exp Eye Res. 2020 Aug;197:108116. doi: 10.1016/j.exer.2020.108116. Epub 2020 Jun 16. PubMed |
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| Long-distance modulation of bystander tumor cells by CD8(+) T cell-secreted IFNgamma. Hoekstra ME, Bornes L, Dijkgraaf FE, Philips D, Pardieck IN, Toebes M, Thommen DS, van Rheenen J, Schumacher TNM. Nat Cancer. 2020 Mar;1(3):291-301. doi: 10.1038/s43018-020-0036-4. Epub 2020 Mar 9. PubMed |
| Functional genomics identifies new synergistic therapies for retinoblastoma. Aubry A, Pearson JD, Huang K, Livne-Bar I, Ahmad M, Jagadeesan M, Khetan V, Ketela T, Brown KR, Yu T, Lu S, Wrana JL, Moffat J, Bremner R. Oncogene. 2020 Jul;39(31):5338-5357. doi: 10.1038/s41388-020-1372-7. Epub 2020 Jun 22. PubMed |
| SUMOylation stabilizes hSSB1 and enhances the recruitment of NBS1 to DNA damage sites. Zhou L, Zheng L, Hu K, Wang X, Zhang R, Zou Y, Zhong L, Wang S, Wu Y, Kang T. Signal Transduct Target Ther. 2020 Jun 24;5(1):80. doi: 10.1038/s41392-020-0172-4. PubMed |
A Conserved Amino Acid in the C Terminus of Human Papillomavirus E7 Mediates Binding to PTPN14 and Repression of Epithelial Differentiation.
Hatterschide J, Brantly AC, Grace M, Munger K, White EA.
J Virol. 2020 Aug 17;94(17). pii: JVI.01024-20. doi: 10.1128/JVI.01024-20. Print 2020 Aug 17.
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| Kinetics and mechanisms of mitotic inheritance of DNA methylation and their roles in aging-associated methylome deterioration. Ming X, Zhang Z, Zou Z, Lv C, Dong Q, He Q, Yi Y, Li Y, Wang H, Zhu B. Cell Res. 2020 Jun 24. pii: 10.1038/s41422-020-0359-9. doi: 10.1038/s41422-020-0359-9. PubMed |
| Lysine-specific demethylase 1A (LSD1) restricts ex vivo propagation of human HSCs and is a target of UM171. Subramaniam A, Zemaitis K, Safaee Talkhoncheh M, Yudovich D, Backstrom A, Debnath S, Chen J, Jain MV, Galeev R, Gaetani M, Zubarev RA, Larsson J. Blood. 2020 Jun 24. pii: 461119. doi: 10.1182/blood.2020005827. PubMed |
| Identification of BLNK and BTK as mediators of rituximab-induced programmed cell death by CRISPR screens in GCB-subtype diffuse large B-cell lymphoma. Thomsen EA, Rovsing AB, Anderson MV, Due H, Huang J, Luo Y, Dybkaer K, Mikkelsen JG. Mol Oncol. 2020 Jun 25. doi: 10.1002/1878-0261.12753. PubMed |
| Genetic and Functional Analyses Point to FAN1 as the Source of Multiple Huntington Disease Modifier Effects. Kim KH, Hong EP, Shin JW, Chao MJ, Loupe J, Gillis T, Mysore JS, Holmans P, Jones L, Orth M, Monckton DG, Long JD, Kwak S, Lee R, Gusella JF, MacDonald ME, Lee JM. Am J Hum Genet. 2020 Jul 2;107(1):96-110. doi: 10.1016/j.ajhg.2020.05.012. Epub 2020 Jun 25. PubMed |
| Recognition of Semaphorin Proteins by P. sordellii Lethal Toxin Reveals Principles of Receptor Specificity in Clostridial Toxins. Lee H, Beilhartz GL, Kucharska I, Raman S, Cui H, Lam MHY, Liang H, Rubinstein JL, Schramek D, Julien JP, Melnyk RA, Taipale M. Cell. 2020 Jul 23;182(2):345-356.e16. doi: 10.1016/j.cell.2020.06.005. Epub 2020 Jun 25. PubMed |
| Depleting interferon regulatory factor-1(IRF-1) with CRISPR/Cas9 attenuates inducible oxidative metabolism without affecting RA-induced differentiation in HL-60 human AML cells. Zhu K, Yue J, Yen A. FASEB Bioadv. 2020 May 22;2(6):354-364. doi: 10.1096/fba.2020-00004. eCollection 2020 Jun. PubMed |
| Highly efficient 'hit-and-run' genome editing with unconcentrated lentivectors carrying Vpr.Prot.Cas9 protein produced from RRE-containing transcripts. Indikova I, Indik S. Nucleic Acids Res. 2020 Aug 20;48(14):8178-8187. doi: 10.1093/nar/gkaa561. PubMed |
| HIF-1 directly induces TET3 expression to enhance 5-hmC density and induce erythroid gene expression in hypoxia. Cao JZ, Liu H, Wickrema A, Godley LA. Blood Adv. 2020 Jul 14;4(13):3053-3062. doi: 10.1182/bloodadvances.2020001535. PubMed |
| CCN1/Cyr61 is required in osteoblasts for responsiveness to the anabolic activity of PTH. Zhao G, Kim EW, Jiang J, Bhoot C, Charles KR, Baek J, Mohan S, Adams JS, Tetradis S, Lyons KM. J Bone Miner Res. 2020 Jul 7. doi: 10.1002/jbmr.4128. PubMed |
| UBE2O Promotes Progression and Epithelial-Mesenchymal Transition in Head and Neck Squamous Cell Carcinoma. Chen X, Zhang S, Liu C, Li G, Lu S, Wang Y, Zhang X, Huang D, Qiu Y, Liu Y. Onco Targets Ther. 2020 Jun 29;13:6191-6202. doi: 10.2147/OTT.S253861. eCollection 2020. PubMed |
| An adipokine feedback regulating diurnal food intake rhythms in mice. Tsang AH, Koch CE, Kiehn JT, Schmidt CX, Oster H. Elife. 2020 Jul 9;9. pii: 55388. doi: 10.7554/eLife.55388. PubMed |
| Impact of 970 nm photobiomodulation therapy on wound healing in cellular models of hidradenitis suppurativa. Zupin L, Ferri G, Tricarico PM, Gratton R, Nait-Meddour C, Ottaviani G, Crovella S. Lasers Med Sci. 2020 Jul 9. pii: 10.1007/s10103-020-03097-w. doi: 10.1007/s10103-020-03097-w. PubMed |
| A Genetic Map of the Response to DNA Damage in Human Cells. Olivieri M, Cho T, Alvarez-Quilon A, Li K, Schellenberg MJ, Zimmermann M, Hustedt N, Rossi SE, Adam S, Melo H, Heijink AM, Sastre-Moreno G, Moatti N, Szilard RK, McEwan A, Ling AK, Serrano-Benitez A, Ubhi T, Feng S, Pawling J, Delgado-Sainz I, Ferguson MW, Dennis JW, Brown GW, Cortes-Ledesma F, Williams RS, Martin A, Xu D, Durocher D. Cell. 2020 Jul 23;182(2):481-496.e21. doi: 10.1016/j.cell.2020.05.040. Epub 2020 Jul 9. PubMed |
| Autophagy alleviates amiodarone-induced hepatotoxicity. Wandrer F, Frangez Z, Liebig S, John K, Vondran F, Wedemeyer H, Veltmann C, Pfeffer TJ, Shibolet O, Schulze-Osthoff K, Simon HU, Bantel H. Arch Toxicol. 2020 Jul 10. pii: 10.1007/s00204-020-02837-9. doi: 10.1007/s00204-020-02837-9. PubMed |
| Endogenous retroviruses are a source of enhancers with oncogenic potential in acute myeloid leukaemia. Deniz O, Ahmed M, Todd CD, Rio-Machin A, Dawson MA, Branco MR. Nat Commun. 2020 Jul 14;11(1):3506. doi: 10.1038/s41467-020-17206-4. PubMed |
| Ribosome Recycling by ABCE1 Links Lysosomal Function and Iron Homeostasis to 3' UTR-Directed Regulation and Nonsense-Mediated Decay. Zhu X, Zhang H, Mendell JT. Cell Rep. 2020 Jul 14;32(2):107895. doi: 10.1016/j.celrep.2020.107895. PubMed |
| Modeling Type 1 Diabetes In Vitro Using Human Pluripotent Stem Cells. Leite NC, Sintov E, Meissner TB, Brehm MA, Greiner DL, Harlan DM, Melton DA. Cell Rep. 2020 Jul 14;32(2):107894. doi: 10.1016/j.celrep.2020.107894. PubMed |
| Piperine suppresses the Wnt/beta-catenin pathway and has anti-cancer effects on colorectal cancer cells. de Almeida GC, Oliveira LFS, Predes D, Fokoue HH, Kuster RM, Oliveira FL, Mendes FA, Abreu JG. Sci Rep. 2020 Jul 15;10(1):11681. doi: 10.1038/s41598-020-68574-2. PubMed |
| Tandem CAR-T cells targeting CD70 and B7-H3 exhibit potent preclinical activity against multiple solid tumors. Yang M, Tang X, Zhang Z, Gu L, Wei H, Zhao S, Zhong K, Mu M, Huang C, Jiang C, Xu J, Guo G, Zhou L, Tong A. Theranostics. 2020 Jun 18;10(17):7622-7634. doi: 10.7150/thno.43991. eCollection 2020. PubMed |
| Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells. Ryu SW, Stewart R, Pectol DC, Ender NA, Wimalarathne O, Lee JH, Zanini CP, Harvey A, Huibregtse JM, Mueller P, Paull TT. PLoS Biol. 2020 Jul 20;18(7):e3000606. doi: 10.1371/journal.pbio.3000606. eCollection 2020 Jul. PubMed |
| Post-transcriptional regulation of MRTF-A by miRNAs during myogenic differentiation of myoblasts. Holstein I, Singh AK, Pohl F, Misiak D, Braun J, Leitner L, Huttelmaier S, Posern G. Nucleic Acids Res. 2020 Jul 21. pii: 5874359. doi: 10.1093/nar/gkaa596. PubMed |
| MRG15 orchestrates rhythmic epigenomic remodelling and controls hepatic lipid metabolism. Wei Y, Tian C, Zhao Y, Liu X, Liu F, Li S, Chen Y, Qiu Y, Feng Z, Chen L, Zhou T, Ren X, Feng C, Liu Y, Yu W, Ying H, Ding Q. Nat Metab. 2020 May;2(5):447-460. doi: 10.1038/s42255-020-0203-z. Epub 2020 May 4. PubMed |
| A pooled genome-wide screening strategy to identify and rank influenza host restriction factors in cell-based vaccine production platforms. Sharon DM, Nesdoly S, Yang HJ, Gelinas JF, Xia Y, Ansorge S, Kamen AA. Sci Rep. 2020 Jul 22;10(1):12166. doi: 10.1038/s41598-020-68934-y. PubMed |
| The CDK4/6-EZH2 pathway is a potential therapeutic target for psoriasis. Muller A, Dickmanns A, Resch C, Schakel K, Hailfinger S, Dobbelstein M, Schulze-Osthoff K, Kramer D. J Clin Invest. 2020 Jul 23. pii: 134217. doi: 10.1172/JCI134217. PubMed |
| The Meningioma Enhancer Landscape Delineates Novel Subgroups and Drives Druggable Dependencies. Prager BC, Vasudevan HN, Dixit D, Bernatchez JA, Wu Q, Wallace LC, Bhargava S, Lee D, King BH, Morton AR, Gimple RC, Pekmezci M, Zhu Z, Siqueira-Neto JL, Wang X, Xie Q, Chen C, Barnett GH, Vogelbaum MA, Mack SC, Chavez L, Perry A, Raleigh DR, Rich JN. Cancer Discov. 2020 Nov;10(11):1722-1741. doi: 10.1158/2159-8290.CD-20-0160. Epub 2020 Jul 23. PubMed |
| Increased lysosomal biomass is responsible for the resistance of triple-negative breast cancers to CDK4/6 inhibition. Fassl A, Brain C, Abu-Remaileh M, Stukan I, Butter D, Stepien P, Feit AS, Bergholz J, Michowski W, Otto T, Sheng Q, Loo A, Michael W, Tiedt R, DeAngelis C, Schiff R, Jiang B, Jovanovic B, Nowak K, Ericsson M, Cameron M, Gray N, Dillon D, Zhao JJ, Sabatini DM, Jeselsohn R, Brown M, Polyak K, Sicinski P. Sci Adv. 2020 Jun 17;6(25):eabb2210. doi: 10.1126/sciadv.abb2210. eCollection 2020 Jun. PubMed |
| Simultaneous Disruption of Both Polyubiquitin Genes Affects Proteasome Function and Decreases Cellular Proliferation. Park CW, Bae JS, Ryu KY. Cell Biochem Biophys. 2020 Sep;78(3):321-329. doi: 10.1007/s12013-020-00933-2. Epub 2020 Jul 23. PubMed |
| TRPV4 Inhibition and CRISPR-Cas9 Knockout Reduce Inflammation Induced by Hyperphysiological Stretching in Human Annulus Fibrosus Cells. Cambria E, Arlt MJE, Wandel S, Krupkova O, Hitzl W, Passini FS, Hausmann ON, Snedeker JG, Ferguson SJ, Wuertz-Kozak K. Cells. 2020 Jul 21;9(7). pii: cells9071736. doi: 10.3390/cells9071736. PubMed |
| Cylindromatosis Lysine 63 Deubiquitinase (CYLD) Regulates NF-kB Signaling Pathway and Modulates Fibroblast and Endothelial Cells Recruitment in Nasopharyngeal Carcinoma. Deng M, Dai W, Yu VZ, Tao L, Lung ML. Cancers (Basel). 2020 Jul 16;12(7). pii: cancers12071924. doi: 10.3390/cancers12071924. PubMed |
| ABHD11 Is Critical for Embryonic Stem Cell Expansion, Differentiation and Lipid Metabolic Homeostasis. Liu G, Ruan Y, Zhang J, Wang X, Wu W, He P, Wang J, Xiong J, Cheng Y, Liu L, Yang Y, Tian Y, Jian R. Front Cell Dev Biol. 2020 Jul 7;8:570. doi: 10.3389/fcell.2020.00570. eCollection 2020. PubMed |
| Targeting the Synthetic Vulnerability of PTEN-Deficient Glioblastoma Cells with MCL1 Inhibitors. Chen C, Zhu S, Zhang X, Zhou T, Gu J, Xu Y, Wan Q, Qi X, Chai Y, Liu X, Chen L, Yan J, Hua Y, Lin F. Mol Cancer Ther. 2020 Oct;19(10):2001-2011. doi: 10.1158/1535-7163.MCT-20-0099. Epub 2020 Jul 31. PubMed |
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| Osteosarcoma-Derived Extracellular Vesicles Induce Lung Fibroblast Reprogramming. Mazumdar A, Urdinez J, Boro A, Migliavacca J, Arlt MJE, Muff R, Fuchs B, Snedeker JG, Gvozdenovic A. Int J Mol Sci. 2020 Jul 30;21(15). pii: ijms21155451. doi: 10.3390/ijms21155451. PubMed |
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| Inhibition of MEK1/2 Forestalls the Onset of Acquired Resistance to Entrectinib in Multiple Models of NTRK1-Driven Cancer. Vaishnavi A, Scherzer MT, Kinsey CG, Parkman GL, Truong A, Ghazi P, Schuman S, Battistone B, Garrido-Laguna I, McMahon M. Cell Rep. 2020 Aug 4;32(5):107994. doi: 10.1016/j.celrep.2020.107994. PubMed |
| Disruption of LTBP4 Induced Activated TGFbeta1, Immunosuppression Signal and Promoted Pulmonary Metastasis in Hepatocellular Carcinoma. Yang X, Ye X, Zhang L, Zhang X, Shu P. Onco Targets Ther. 2020 Jul 20;13:7007-7017. doi: 10.2147/OTT.S246766. eCollection 2020. PubMed |
| Molecular determinants of SR-B1-dependent Plasmodium sporozoite entry into hepatocytes. Langlois AC, Manzoni G, Vincensini L, Coppee R, Marinach C, Guerin M, Huby T, Carriere V, Cosset FL, Dreux M, Rubinstein E, Silvie O. Sci Rep. 2020 Aug 11;10(1):13509. doi: 10.1038/s41598-020-70468-2. PubMed |
| Human GBP1 Differentially Targets Salmonella and Toxoplasma to License Recognition of Microbial Ligands and Caspase-Mediated Death. Fisch D, Clough B, Domart MC, Encheva V, Bando H, Snijders AP, Collinson LM, Yamamoto M, Shenoy AR, Frickel EM. Cell Rep. 2020 Aug 11;32(6):108008. doi: 10.1016/j.celrep.2020.108008. PubMed |
| Splicing variation of BMP2K balances abundance of COPII assemblies and autophagic degradation in erythroid cells. Cendrowski J, Kaczmarek M, Mazur M, Kuzmicz-Kowalska K, Jastrzebski K, Brewinska-Olchowik M, Kominek A, Piwocka K, Miaczynska M. Elife. 2020 Aug 14;9. pii: 58504. doi: 10.7554/eLife.58504. PubMed |
Enhancer RNAs predict enhancer-gene regulatory links and are critical for enhancer function in neuronal systems.
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| Functional Interplay between Histone H2B ADP-Ribosylation and Phosphorylation Controls Adipogenesis. Huang D, Camacho CV, Setlem R, Ryu KW, Parameswaran B, Gupta RK, Kraus WL. Mol Cell. 2020 Sep 17;79(6):934-949.e14. doi: 10.1016/j.molcel.2020.08.002. Epub 2020 Aug 20. PubMed |
| Proteosomal degradation of NSD2 by BRCA1 promotes leukemia cell differentiation. Park JW, Kang JY, Hahm JY, Kim HJ, Seo SB. Commun Biol. 2020 Aug 21;3(1):462. doi: 10.1038/s42003-020-01186-8. PubMed |
| Diverse noncoding mutations contribute to deregulation of cis-regulatory landscape in pediatric cancers. He B, Gao P, Ding YY, Chen CH, Chen G, Chen C, Kim H, Tasian SK, Hunger SP, Tan K. Sci Adv. 2020 Jul 24;6(30):eaba3064. doi: 10.1126/sciadv.aba3064. eCollection 2020 Jul. PubMed |
| Genomic profiling of the transcription factor Zfp148 and its impact on the p53 pathway. Zou ZV, Gul N, Lindberg M, Bokhari AA, Eklund EM, Garellick V, Patel AAH, Dzanan JJ, Titmuss BO, Le Gal K, Johansson I, Tivesten A, Forssell-Aronsson E, Bergo MO, Staffas A, Larsson E, Sayin VI, Lindahl P. Sci Rep. 2020 Aug 25;10(1):14156. doi: 10.1038/s41598-020-70824-2. PubMed |
| Genetic evidence for an inhibitory role of tomosyn in insulin-stimulated GLUT4 exocytosis. Wang S, Liu Y, Crisman L, Wan C, Miller J, Yu H, Shen J. Traffic. 2020 Oct;21(10):636-646. doi: 10.1111/tra.12760. PubMed |
| KIAA1522 potentiates TNFalpha-NFkappaB signaling to antagonize platinum-based chemotherapy in lung adenocarcinoma. Wang B, Jing T, Jin W, Chen J, Wu C, Wang M, Liu Y. J Exp Clin Cancer Res. 2020 Aug 27;39(1):170. doi: 10.1186/s13046-020-01684-x. PubMed |
| HIV-1 resists MxB inhibition of viral Rev protein. Wang Z, Chai K, Liu Q, Yi DR, Pan Q, Huang Y, Tan J, Qiao W, Guo F, Cen S, Liang C. Emerg Microbes Infect. 2020 Dec;9(1):2030-2045. doi: 10.1080/22221751.2020.1818633. PubMed |
| Most Commonly Mutated Genes in High-Grade Serous Ovarian Carcinoma Are Nonessential for Ovarian Surface Epithelial Stem Cell Transformation. Yamulla RJ, Nalubola S, Flesken-Nikitin A, Nikitin AY, Schimenti JC. Cell Rep. 2020 Sep 1;32(9):108086. doi: 10.1016/j.celrep.2020.108086. PubMed |
| GATA-1-dependent histone H3K27 acetylation mediates erythroid cell-specific chromatin interaction between CTCF sites. Kim YW, Kang Y, Kang J, Kim A. FASEB J. 2020 Nov;34(11):14736-14749. doi: 10.1096/fj.202001526R. Epub 2020 Sep 14. PubMed |
| Regulation of dopamine-dependent transcription and cocaine action by Gadd45b. Zipperly ME, Sultan FA, Graham GE, Brane AC, Simpkins NA, Carullo NVN, Ianov L, Day JJ. Neuropsychopharmacology. 2021 Mar;46(4):709-720. doi: 10.1038/s41386-020-00828-z. Epub 2020 Sep 14. PubMed |
| Dual blockade of CD47 and HER2 eliminates radioresistant breast cancer cells. Candas-Green D, Xie B, Huang J, Fan M, Wang A, Menaa C, Zhang Y, Zhang L, Jing D, Azghadi S, Zhou W, Liu L, Jiang N, Li T, Gao T, Sweeney C, Shen R, Lin TY, Pan CX, Ozpiskin OM, Woloschak G, Grdina DJ, Vaughan AT, Wang JM, Xia S, Monjazeb AM, Murphy WJ, Sun LQ, Chen HW, Lam KS, Weichselbaum RR, Li JJ. Nat Commun. 2020 Sep 14;11(1):4591. doi: 10.1038/s41467-020-18245-7. PubMed |
| The sustained expression of Cas9 targeting toxic RNAs reverses disease phenotypes in mouse models of myotonic dystrophy type 1. Batra R, Nelles DA, Roth DM, Krach F, Nutter CA, Tadokoro T, Thomas JD, Sznajder LJ, Blue SM, Gutierrez HL, Liu P, Aigner S, Platoshyn O, Miyanohara A, Marsala M, Swanson MS, Yeo GW. Nat Biomed Eng. 2021 Feb;5(2):157-168. doi: 10.1038/s41551-020-00607-7. Epub 2020 Sep 14. PubMed |
| LncRNA DSCAM-AS1 interacts with YBX1 to promote cancer progression by forming a positive feedback loop that activates FOXA1 transcription network. Zhang Y, Huang YX, Wang DL, Yang B, Yan HY, Lin LH, Li Y, Chen J, Xie LM, Huang YS, Liao JY, Hu KS, He JH, Saw PE, Xu X, Yin D. Theranostics. 2020 Aug 29;10(23):10823-10837. doi: 10.7150/thno.47830. eCollection 2020. PubMed |
| MAPK activity dynamics regulate non-cell autonomous effects of oncogene expression. Aikin TJ, Peterson AF, Pokrass MJ, Clark HR, Regot S. Elife. 2020 Sep 17;9. pii: 60541. doi: 10.7554/eLife.60541. PubMed |
| Reticulon-3 modulates the incorporation of replication competent hepatitis C virus molecules for release inside infectious exosomes. Li J, Abosmaha E, Coffin CS, Labonte P, Bukong TN. PLoS One. 2020 Sep 17;15(9):e0239153. doi: 10.1371/journal.pone.0239153. eCollection 2020. PubMed |
HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation.
Magupalli VG, Negro R, Tian Y, Hauenstein AV, Di Caprio G, Skillern W, Deng Q, Orning P, Alam HB, Maliga Z, Sharif H, Hu JJ, Evavold CL, Kagan JC, Schmidt FI, Fitzgerald KA, Kirchhausen T, Li Y, Wu H.
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| mTOR-mediated cancer drug resistance suppresses autophagy and generates a druggable metabolic vulnerability. Gremke N, Polo P, Dort A, Schneikert J, Elmshauser S, Brehm C, Klingmuller U, Schmitt A, Reinhardt HC, Timofeev O, Wanzel M, Stiewe T. Nat Commun. 2020 Sep 17;11(1):4684. doi: 10.1038/s41467-020-18504-7. PubMed |
| Cholesterol 25-Hydroxylase inhibits SARS-CoV-2 and other coronaviruses by depleting membrane cholesterol. Wang S, Li W, Hui H, Tiwari SK, Zhang Q, Croker BA, Rawlings S, Smith D, Carlin AF, Rana TM. EMBO J. 2020 Nov 2;39(21):e106057. doi: 10.15252/embj.2020106057. Epub 2020 Oct 5. PubMed |
| RNA localization and co-translational interactions control RAB13 GTPase function and cell migration. Moissoglu K, Stueland M, Gasparski AN, Wang T, Jenkins LM, Hastings ML, Mili S. EMBO J. 2020 Nov 2;39(21):e104958. doi: 10.15252/embj.2020104958. Epub 2020 Sep 18. PubMed |
| RPS5 interacts with the rabbit hemorrhagic disease virus 3' extremities region and plays a role in virus replication. Guo H, Zhu J, Miao Q, Qi R, Tang A, Liu C, Yang H, Yuan L, Liu G. Vet Microbiol. 2020 Oct;249:108858. doi: 10.1016/j.vetmic.2020.108858. Epub 2020 Sep 18. PubMed |
| STAT5 promotes accessibility and is required for BATF-mediated plasticity at the Il9 locus. Fu Y, Wang J, Panangipalli G, Ulrich BJ, Koh B, Xu C, Kharwadkar R, Chu X, Wang Y, Gao H, Wu W, Sun J, Tepper RS, Zhou B, Janga SC, Yang K, Kaplan MH. Nat Commun. 2020 Sep 28;11(1):4882. doi: 10.1038/s41467-020-18648-6. PubMed |
| UV damage induces G3BP1-dependent stress granule formation that is not driven by mTOR inhibition-mediated translation arrest. Ying S, Khaperskyy DA. J Cell Sci. 2020 Oct 28;133(20). pii: jcs.248310. doi: 10.1242/jcs.248310. PubMed |
| Identification of Cx45 as a Major Component of GJs in HeLa Cells. Choi EJ, Palacios-Prado N, Saez JC, Lee J. Biomolecules. 2020 Sep 29;10(10). pii: biom10101389. doi: 10.3390/biom10101389. PubMed |
| Involvement of CYP2E1-ROS-CD36/DGAT2 axis in the pathogenesis of VPA-induced hepatic steatosis in vivo and in vitro. Ma L, Wang Y, Chen X, Zhao L, Guo Y. Toxicology. 2020 Dec 1;445:152585. doi: 10.1016/j.tox.2020.152585. Epub 2020 Sep 29. PubMed |
| HDAC6 Regulates Radiosensitivity of Non-Small Cell Lung Cancer by Promoting Degradation of Chk1. Moses N, Zhang M, Wu JY, Hu C, Xiang S, Geng X, Chen Y, Bai W, Zhang YW, Bepler G, Zhang XM. Cells. 2020 Oct 4;9(10). pii: cells9102237. doi: 10.3390/cells9102237. PubMed |
| A system-level approach identifies HIF-2alpha as a critical regulator of chondrosarcoma progression. Kim H, Cho Y, Kim HS, Kang D, Cheon D, Kim YJ, Chang MJ, Lee KM, Chang CB, Kang SB, Kang HG, Kim JH. Nat Commun. 2020 Oct 6;11(1):5023. doi: 10.1038/s41467-020-18817-7. PubMed |
| MYD88 L265P elicits mutation-specific ubiquitination to drive NF-kappaB activation and lymphomagenesis. Yu X, Li W, Deng Q, Liu H, Wang X, Hu H, Cao Y, Xu-Monette ZY, Li L, Zhang M, Lu Z, Young KH, Li Y. Blood. 2021 Mar 25;137(12):1615-1627. doi: 10.1182/blood.2020004918. PubMed |
| Extracellular Matrix-Bound FGF2 Mediates Estrogen Receptor Signaling and Therapeutic Response in Breast Cancer. DiGiacomo JW, Godet I, Trautmann-Rodriguez M, Gilkes DM. Mol Cancer Res. 2021 Jan;19(1):136-149. doi: 10.1158/1541-7786.MCR-20-0554. Epub 2020 Oct 8. PubMed |
| Ovarian cancer cells direct monocyte differentiation through a non-canonical pathway. Fogg KC, Miller AE, Li Y, Flanigan W, Walker A, O'Shea A, Kendziorski C, Kreeger PK. BMC Cancer. 2020 Oct 17;20(1):1008. doi: 10.1186/s12885-020-07513-w. PubMed |
| CRISPR/Cas9-mediated gene knockout in human adipose stem/progenitor cells. Mandl M, Ritthammer H, Ejaz A, Wagner SA, Hatzmann FM, Baumgarten S, Viertler HP, Zwierzina ME, Mattesich M, Schiller V, Rauchenwald T, Ploner C, Waldegger P, Pierer G, Zwerschke W. Adipocyte. 2020 Dec;9(1):626-635. doi: 10.1080/21623945.2020.1834230. PubMed |
| The Human-Specific STING Agonist G10 Activates Type I Interferon and the NLRP3 Inflammasome in Porcine Cells. Ming SL, Zeng L, Guo YK, Zhang S, Li GL, Ma YX, Zhai YY, Chang WR, Yang L, Wang J, Yang GY, Chu BB. Front Immunol. 2020 Sep 24;11:575818. doi: 10.3389/fimmu.2020.575818. eCollection 2020. PubMed |
| Phosphoinositide 3'-Kinase gamma Facilitates Polyomavirus Infection. Clark P, Gee GV, Albright BS, Assetta B, Han Y, Atwood WJ, DiMaio D. Viruses. 2020 Oct 20;12(10). pii: v12101190. doi: 10.3390/v12101190. PubMed |
| Enteroviral 3C protease activates the human NLRP1 inflammasome in airway epithelia. Robinson KS, Teo DET, Tan KS, Toh GA, Ong HH, Lim CK, Lay K, Au BV, Lew TS, Chu JJH, Chow VTK, Wang Y, Zhong FL, Reversade B. Science. 2020 Dec 4;370(6521). pii: science.aay2002. doi: 10.1126/science.aay2002. Epub 2020 Oct 22. PubMed |
| Priming Is Dispensable for NLRP3 Inflammasome Activation in Human Monocytes In Vitro. Gritsenko A, Yu S, Martin-Sanchez F, Diaz-Del-Olmo I, Nichols EM, Davis DM, Brough D, Lopez-Castejon G. Front Immunol. 2020 Sep 30;11:565924. doi: 10.3389/fimmu.2020.565924. eCollection 2020. PubMed |
Metabolic plasticity of IDH1-mutant glioma cell lines is responsible for low sensitivity to glutaminase inhibition.
Ruiz-Rodado V, Lita A, Dowdy T, Celiku O, Saldana AC, Wang H, Yang CZ, Chari R, Li A, Zhang W, Song H, Zhang M, Ahn S, Davis D, Chen X, Zhuang Z, Herold-Mende C, Walters KJ, Gilbert MR, Larion M.
Cancer Metab. 2020 Oct 21;8:23. doi: 10.1186/s40170-020-00229-2. eCollection 2020.
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| SHOC2 Is a Critical Modulator of Sensitivity to EGFR-TKIs in Non-Small Cell Lung Cancer Cells. Terai H, Hamamoto J, Emoto K, Masuda T, Manabe T, Kuronuma S, Kobayashi K, Masuzawa K, Ikemura S, Nakayama S, Kawada I, Suzuki Y, Takeuchi O, Suzuki Y, Ohtsuki S, Yasuda H, Soejima K, Fukunaga K. Mol Cancer Res. 2021 Feb;19(2):317-328. doi: 10.1158/1541-7786.MCR-20-0664. Epub 2020 Oct 26. PubMed |
| Activation of Clustered IFNgamma Target Genes Drives Cohesin-Controlled Transcriptional Memory. Siwek W, Tehrani SSH, Mata JF, Jansen LET. Mol Cell. 2020 Nov 5;80(3):396-409.e6. doi: 10.1016/j.molcel.2020.10.005. Epub 2020 Oct 26. PubMed |
| ATF4 links ER stress with reticulophagy in glioblastoma cells. Zielke S, Kardo S, Zein L, Mari M, Covarrubias-Pinto A, Kinzler MN, Meyer N, Stolz A, Fulda S, Reggiori F, Kogel D, van Wijk S. Autophagy. 2021 Sep;17(9):2432-2448. doi: 10.1080/15548627.2020.1827780. Epub 2020 Oct 28. PubMed |
| Chemotherapy-Induced Upregulation of Small Extracellular Vesicle-Associated PTX3 Accelerates Breast Cancer Metastasis. Wills CA, Liu X, Chen L, Zhao Y, Dower CM, Sundstrom J, Wang HG. Cancer Res. 2021 Jan 15;81(2):452-463. doi: 10.1158/0008-5472.CAN-20-1976. Epub 2020 Oct 28. PubMed |
| Histone Demethylase JMJD3 Mediated Doxorubicin-Induced Cardiomyopathy by Suppressing SESN2 Expression. Wang P, Lan R, Guo Z, Cai S, Wang J, Wang Q, Li Z, Li Z, Wang Q, Li J, Wu Z, Lu J, Liu P. Front Cell Dev Biol. 2020 Sep 29;8:548605. doi: 10.3389/fcell.2020.548605. eCollection 2020. PubMed |
| Multiplexed tat-Targeting CRISPR-Cas9 Protects T Cells from Acute HIV-1 Infection with Inhibition of Viral Escape. Ophinni Y, Miki S, Hayashi Y, Kameoka M. Viruses. 2020 Oct 28;12(11). pii: v12111223. doi: 10.3390/v12111223. PubMed |
| Netrin G1 Promotes Pancreatic Tumorigenesis through Cancer-Associated Fibroblast-Driven Nutritional Support and Immunosuppression. Francescone R, Barbosa Vendramini-Costa D, Franco-Barraza J, Wagner J, Muir A, Lau AN, Gabitova L, Pazina T, Gupta S, Luong T, Rollins D, Malik R, Thapa RJ, Restifo D, Zhou Y, Cai KQ, Hensley HH, Tan Y, Kruger WD, Devarajan K, Balachandran S, Klein-Szanto AJ, Wang H, El-Deiry WS, Vander Heiden MG, Peri S, Campbell KS, Astsaturov I, Cukierman E. Cancer Discov. 2021 Feb;11(2):446-479. doi: 10.1158/2159-8290.CD-20-0775. Epub 2020 Oct 30. PubMed |
| Broad genic repression domains signify enhanced silencing of oncogenes. Zhao D, Zhang L, Zhang M, Xia B, Lv J, Gao X, Wang G, Meng Q, Yi Y, Zhu S, Tomoiaga AS, Lee MG, Cooke JP, Cao Q, Chen K. Nat Commun. 2020 Nov 3;11(1):5560. doi: 10.1038/s41467-020-18913-8. PubMed |
Genome-wide CRISPR Screens Reveal Host Factors Critical for SARS-CoV-2 Infection.
Wei J, Alfajaro MM, DeWeirdt PC, Hanna RE, Lu-Culligan WJ, Cai WL, Strine MS, Zhang SM, Graziano VR, Schmitz CO, Chen JS, Mankowski MC, Filler RB, Ravindra NG, Gasque V, de Miguel FJ, Patil A, Chen H, Oguntuyo KY, Abriola L, Surovtseva YV, Orchard RC, Lee B, Lindenbach BD, Politi K, van Dijk D, Kadoch C, Simon MD, Yan Q, Doench JG, Wilen CB.
Cell. 2021 Jan 7;184(1):76-91.e13. doi: 10.1016/j.cell.2020.10.028. Epub 2020 Oct 20.
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| Clathrin- and dynamin-dependent endocytosis limits canonical NF-kappaB signaling triggered by lymphotoxin beta receptor. Maksymowicz M, Miaczynska M, Banach-Orlowska M. Cell Commun Signal. 2020 Nov 4;18(1):176. doi: 10.1186/s12964-020-00664-0. PubMed |
| Normal vitreous promotes angiogenesis via activation of Axl. Wu W, Xia X, Tang L, Yao F, Xu H, Lei H. FASEB J. 2021 Jan;35(1):e21152. doi: 10.1096/fj.201903105R. Epub 2020 Nov 5. PubMed |
Functional Genomics In Vivo Reveal Metabolic Dependencies of Pancreatic Cancer Cells.
Zhu XG, Chudnovskiy A, Baudrier L, Prizer B, Liu Y, Ostendorf BN, Yamaguchi N, Arab A, Tavora B, Timson R, Heissel S, de Stanchina E, Molina H, Victora GD, Goodarzi H, Birsoy K.
Cell Metab. 2020 Oct 28. pii: S1550-4131(20)30550-7. doi: 10.1016/j.cmet.2020.10.017.
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ZNF354C is a transcriptional repressor that inhibits endothelial angiogenic sprouting.
Oo JA, Irmer B, Gunther S, Warwick T, Palfi K, Izquierdo Ponce J, Teichmann T, Pfluger-Muller B, Gilsbach R, Brandes RP, Leisegang MS.
Sci Rep. 2020 Nov 5;10(1):19079. doi: 10.1038/s41598-020-76193-0.
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| Sustained TNF-alpha stimulation leads to transcriptional memory that greatly enhances signal sensitivity and robustness. Zhao Z, Zhang Z, Li J, Dong Q, Xiong J, Li Y, Lan M, Li G, Zhu B. Elife. 2020 Nov 6;9. pii: 61965. doi: 10.7554/eLife.61965. PubMed |
| Genetically Defined, Syngeneic Organoid Platform for Developing Combination Therapies for Ovarian Cancer. Zhang S, Iyer S, Ran H, Dolgalev I, Gu S, Wei W, Foster CJR, Loomis CA, Olvera N, Dao F, Levine DA, Weinberg RA, Neel BG. Cancer Discov. 2021 Feb;11(2):362-383. doi: 10.1158/2159-8290.CD-20-0455. Epub 2020 Nov 6. PubMed |
| CRISPR-Cas9-mediated knockout of GCN2 reveals a critical role in sensing amino acid deprivation in bovine mammary epithelial cells. Edick AM, Audette J, Burgos SA. J Dairy Sci. 2021 Jan;104(1):1123-1135. doi: 10.3168/jds.2020-18700. Epub 2020 Nov 6. PubMed |
| Regulation of PD-L1 expression in K-ras-driven cancers through ROS-mediated FGFR1 signaling. Glorieux C, Xia X, He YQ, Hu Y, Cremer K, Robert A, Liu J, Wang F, Ling J, Chiao PJ, Huang P. Redox Biol. 2021 Jan;38:101780. doi: 10.1016/j.redox.2020.101780. Epub 2020 Nov 3. PubMed |
| AMPKalpha1 Regulates Lung and Breast Cancer Progression by Regulating TLR4-Mediated TRAF6-BECN1 Signaling Axis. Kim MJ, Min Y, Son J, Kim JY, Lee JS, Kim DH, Lee KY. Cancers (Basel). 2020 Nov 6;12(11). pii: cancers12113289. doi: 10.3390/cancers12113289. PubMed |
| Human Cytomegalovirus Interactions with the Basement Membrane Protein Nidogen 1. Kuan MI, Jaeger HK, Balemba OB, O'Dowd JM, Duricka D, Hannemann H, Marx E, Teissier N, Gabrielli L, Bonasoni MP, Keithley EM, Fortunato EA. J Virol. 2021 Jan 13;95(3). pii: JVI.01506-20. doi: 10.1128/JVI.01506-20. Print 2021 Jan 13. PubMed |
| A ubiquitin ligase mediates target-directed microRNA decay independently of tailing and trimming. Han J, LaVigne CA, Jones BT, Zhang H, Gillett F, Mendell JT. Science. 2020 Dec 18;370(6523). pii: science.abc9546. doi: 10.1126/science.abc9546. Epub 2020 Nov 12. PubMed |
| Engineering of alpha-PD-1 antibody-expressing long-lived plasma cells by CRISPR/Cas9-mediated targeted gene integration. Luo B, Zhan Y, Luo M, Dong H, Liu J, Lin Y, Zhang J, Wang G, Verhoeyen E, Zhang Y, Zhang H. Cell Death Dis. 2020 Nov 12;11(11):973. doi: 10.1038/s41419-020-03187-1. PubMed |
| PARP1 and PRC2 double deficiency promotes BRCA-proficient breast cancer growth by modification of the tumor microenvironment. Yang AY, Choi EB, So Park M, Kim SK, Park MS, Kim MY. FEBS J. 2021 May;288(9):2888-2910. doi: 10.1111/febs.15636. Epub 2020 Dec 2. PubMed |
| Regulation of cytokine signaling through direct interaction between cytokine receptors and the ATG16L1 WD40 domain. Serramito-Gomez I, Boada-Romero E, Villamuera R, Fernandez-Cabrera A, Cedillo JL, Martin-Regalado A, Carding S, Mayer U, Powell PP, Wileman T, Garcia-Higuera I, Pimentel-Muinos FX. Nat Commun. 2020 Nov 20;11(1):5919. doi: 10.1038/s41467-020-19670-4. PubMed |
| Mast4 knockout shows the regulation of spermatogonial stem cell self-renewal via the FGF2/ERM pathway. Lee SJ, Park J, Lee DJ, Otsu K, Kim P, Mizuno S, Lee MJ, Kim HY, Harada H, Takahashi S, Kim SJ, Jung HS. Cell Death Differ. 2021 May;28(5):1441-1454. doi: 10.1038/s41418-020-00670-2. Epub 2020 Nov 20. PubMed |
| Integrative analysis reveals novel driver genes and molecular subclasses of hepatocellular carcinoma. Yang L, Zhang Z, Sun Y, Pang S, Yao Q, Lin P, Cheng J, Li J, Ding G, Hui L, Li Y, Li H. Aging (Albany NY). 2020 Nov 20;12(23):23849-23871. doi: 10.18632/aging.104047. Epub 2020 Nov 20. PubMed |
| Relative expression of KLK5 to LEKTI is associated with aggressiveness of oral squamous cell carcinoma. Alves MG, Kodama MH, da Silva EZM, Gomes BBM, da Silva RAA, Vieira GV, Alves VM, da Fonseca CK, Santana AC, Cecilio NT, Costa MSA, Jamur MC, Oliver C, Cunha TM, Bugge TH, Braz-Silva PH, Colli LM, Sales KU. Transl Oncol. 2021 Jan;14(1):100970. doi: 10.1016/j.tranon.2020.100970. Epub 2020 Nov 28. PubMed |
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| CRISPR Screening of CAR T Cells and Cancer Stem Cells Reveals Critical Dependencies for Cell-Based Therapies. Wang D, Prager BC, Gimple RC, Aguilar B, Alizadeh D, Tang H, Lv D, Starr R, Brito A, Wu Q, Kim LJY, Qiu Z, Lin P, Lorenzini MH, Badie B, Forman SJ, Xie Q, Brown CE, Rich JN. Cancer Discov. 2021 May;11(5):1192-1211. doi: 10.1158/2159-8290.CD-20-1243. Epub 2020 Dec 16. PubMed |
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| Genetic Screens Identify Host Factors for SARS-CoV-2 and Common Cold Coronaviruses. Wang R, Simoneau CR, Kulsuptrakul J, Bouhaddou M, Travisano KA, Hayashi JM, Carlson-Stevermer J, Zengel JR, Richards CM, Fozouni P, Oki J, Rodriguez L, Joehnk B, Walcott K, Holden K, Sil A, Carette JE, Krogan NJ, Ott M, Puschnik AS. Cell. 2021 Jan 7;184(1):106-119.e14. doi: 10.1016/j.cell.2020.12.004. Epub 2020 Dec 9. PubMed |
| TMEM41B Is a Pan-flavivirus Host Factor. Hoffmann HH, Schneider WM, Rozen-Gagnon K, Miles LA, Schuster F, Razooky B, Jacobson E, Wu X, Yi S, Rudin CM, MacDonald MR, McMullan LK, Poirier JT, Rice CM. Cell. 2021 Jan 7;184(1):133-148.e20. doi: 10.1016/j.cell.2020.12.005. Epub 2020 Dec 9. PubMed |
| MLH1 Deficiency-Triggered DNA Hyperexcision by Exonuclease 1 Activates the cGAS-STING Pathway. Guan J, Lu C, Jin Q, Lu H, Chen X, Tian L, Zhang Y, Ortega J, Zhang J, Siteni S, Chen M, Gu L, Shay JW, Davis AJ, Chen ZJ, Fu YX, Li GM. Cancer Cell. 2021 Jan 11;39(1):109-121.e5. doi: 10.1016/j.ccell.2020.11.004. Epub 2020 Dec 17. PubMed |
| Anti-pyroptotic function of TGF-beta is suppressed by a synthetic dsRNA analogue in triple negative breast cancer cells. Tamura Y, Morikawa M, Tanabe R, Miyazono K, Koinuma D. Mol Oncol. 2021 May;15(5):1289-1307. doi: 10.1002/1878-0261.12890. Epub 2021 Jan 4. PubMed |
| BAP1 deletion abrogates growth and metastasis of murine cutaneous melanoma. Luo X, Xu Y, Li Y, Zhang G, Huang S, Liu X, Ren Z, Liu S, Yu L. Melanoma Res. 2021 Apr 1;31(2):119-129. doi: 10.1097/CMR.0000000000000714. PubMed |
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| FGF21 Induced by the ASK1-p38 Pathway Promotes Mechanical Cell Competition by Attracting Cells. Ogawa M, Kawarazaki Y, Fujita Y, Naguro I, Ichijo H. Curr Biol. 2021 Mar 8;31(5):1048-1057.e5. doi: 10.1016/j.cub.2020.11.052. Epub 2020 Dec 22. PubMed |
| CRISPR/Cas9-Constructed Pseudorabies Virus Mutants Reveal the Importance of UL13 in Alphaherpesvirus Escape from Genome Silencing. Van Cleemput J, Koyuncu OO, Laval K, Engel EA, Enquist LW. J Virol. 2021 Feb 24;95(6). pii: JVI.02286-20. doi: 10.1128/JVI.02286-20. Print 2021 Feb 24. PubMed |
| A CRISPR-Cas13a Based Strategy That Tracks and Degrades Toxic RNA in Myotonic Dystrophy Type 1. Zhang N, Bewick B, Xia G, Furling D, Ashizawa T. Front Genet. 2020 Dec 10;11:594576. doi: 10.3389/fgene.2020.594576. eCollection 2020. PubMed |
| A novel circulating tamiami mammarenavirus shows potential for zoonotic spillover. Moreno H, Rastrojo A, Pryce R, Fedeli C, Zimmer G, Bowden TA, Gerold G, Kunz S. PLoS Negl Trop Dis. 2020 Dec 28;14(12):e0009004. doi: 10.1371/journal.pntd.0009004. eCollection 2020 Dec. PubMed |
| Differential Regulation of Cancer Progression by CDK4/6 Plays a Central Role in DNA Replication and Repair Pathways. Dai M, Boudreault J, Wang N, Poulet S, Daliah G, Yan G, Moamer A, Burgos SA, Sabri S, Ali S, Lebrun JJ. Cancer Res. 2021 Mar 1;81(5):1332-1346. doi: 10.1158/0008-5472.CAN-20-2121. Epub 2020 Dec 28. PubMed |
| Genome-wide CRISPR screen identifies regulators of MAPK and MTOR pathways mediating sorafenib resistance in acute myeloid leukemia. Damnernsawad A, Bottomly D, Kurtz SE, Eide CA, McWeeney SK, Tyner JW, Nechiporuk T. Haematologica. 2020 Dec 30;Online ahead of print. doi: 10.3324/haematol.2020.257964. PubMed |
| Genome-Scale Identification of SARS-CoV-2 and Pan-coronavirus Host Factor Networks. Schneider WM, Luna JM, Hoffmann HH, Sanchez-Rivera FJ, Leal AA, Ashbrook AW, Le Pen J, Ricardo-Lax I, Michailidis E, Peace A, Stenzel AF, Lowe SW, MacDonald MR, Rice CM, Poirier JT. Cell. 2021 Jan 7;184(1):120-132.e14. doi: 10.1016/j.cell.2020.12.006. Epub 2020 Dec 9. PubMed |
| Alteration in stemness causes exclusivity between Epstein-Barr virus-positivity and microsatellite instability status in gastric cancer. Kim Y, Shin YJ, Wen X, Cho NY, Li M, Kim YJ, Song SH, Kang GH. Gastric Cancer. 2021 May;24(3):602-610. doi: 10.1007/s10120-020-01146-5. Epub 2021 Jan 2. PubMed |
| Gain-of-function hot spot mutant p53(R248Q) regulation of integrin/FAK/ERK signaling in esophageal squamous cell carcinoma. Yu VZ, So SS, Lung ML. Transl Oncol. 2021 Jan;14(1):100982. doi: 10.1016/j.tranon.2020.100982. Epub 2020 Dec 11. PubMed |
| Promoter-proximal CTCF binding promotes distal enhancer-dependent gene activation. Kubo N, Ishii H, Xiong X, Bianco S, Meitinger F, Hu R, Hocker JD, Conte M, Gorkin D, Yu M, Li B, Dixon JR, Hu M, Nicodemi M, Zhao H, Ren B. Nat Struct Mol Biol. 2021 Feb;28(2):152-161. doi: 10.1038/s41594-020-00539-5. Epub 2021 Jan 4. PubMed |
| Gut-licensed IFNgamma(+) NK cells drive LAMP1(+)TRAIL(+) anti-inflammatory astrocytes. Sanmarco LM, Wheeler MA, Gutierrez-Vazquez C, Polonio CM, Linnerbauer M, Pinho-Ribeiro FA, Li Z, Giovannoni F, Batterman KV, Scalisi G, Zandee SEJ, Heck ES, Alsuwailm M, Rosene DL, Becher B, Chiu IM, Prat A, Quintana FJ. Nature. 2021 Feb;590(7846):473-479. doi: 10.1038/s41586-020-03116-4. Epub 2021 Jan 6. PubMed |
| Structural basis for distinct inflammasome complex assembly by human NLRP1 and CARD8. Gong Q, Robinson K, Xu C, Huynh PT, Chong KHC, Tan EYJ, Zhang J, Boo ZZ, Teo DET, Lay K, Zhang Y, Lim JSY, Goh WI, Wright G, Zhong FL, Reversade B, Wu B. Nat Commun. 2021 Jan 8;12(1):188. doi: 10.1038/s41467-020-20319-5. PubMed |
| Multiplex gene targeting in the mouse embryo using a Cas9-Cpf1 hybrid guide RNA. Oh SH, Lee HJ, Ahn MK, Jeon MY, Yoon JS, Jung YJ, Kim GN, Baek IJ, Kim I, Kim KM, Sung YH. Biochem Biophys Res Commun. 2021 Feb 5;539:48-55. doi: 10.1016/j.bbrc.2020.12.072. Epub 2021 Jan 6. PubMed |
| Modulation of immune cell reactivity with cis-binding Siglec agonists. Delaveris CS, Chiu SH, Riley NM, Bertozzi CR. Proc Natl Acad Sci U S A. 2021 Jan 19;118(3). pii: 2012408118. doi: 10.1073/pnas.2012408118. PubMed |
| Isolation of MERS-related coronavirus from lesser bamboo bats that uses DPP4 and infects human-DPP4-transgenic mice. Lau SKP, Fan RYY, Zhu L, Li KSM, Wong ACP, Luk HKH, Wong EYM, Lam CSF, Lo GCS, Fung J, He Z, Fok FCH, Au-Yeung RKH, Zhang L, Kok KH, Yuen KY, Woo PCY. Nat Commun. 2021 Jan 11;12(1):216. doi: 10.1038/s41467-020-20458-9. PubMed |
Reticulon-3 Promotes Endosome Maturation at ER Membrane Contact Sites.
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| Long non-coding RNA LINC00665 promotes gemcitabine resistance of Cholangiocarcinoma cells via regulating EMT and stemness properties through miR-424-5p/BCL9L axis. Lu M, Qin X, Zhou Y, Li G, Liu Z, Geng X, Yue H. Cell Death Dis. 2021 Jan 12;12(1):72. doi: 10.1038/s41419-020-03346-4. PubMed |
| Differential effects on human cytochromes P450 by CRISPR/Cas9-induced genetic knockout of cytochrome P450 reductase and cytochrome b5 in HepaRG cells. Heintze T, Klein K, Hofmann U, Zanger UM. Sci Rep. 2021 Jan 13;11(1):1000. doi: 10.1038/s41598-020-79952-1. PubMed |
| The Ligand of Ate1 is intrinsically disordered and participates in nucleolar phase separation regulated by Jumonji Domain Containing 6. Arva A, Kasu YAT, Duncan J, Alkhatatbeh MA, Brower CS. Proc Natl Acad Sci U S A. 2021 Jan 5;118(1). pii: 2015887118. doi: 10.1073/pnas.2015887118. Epub 2020 Dec 21. PubMed |
| EBF1 drives hallmark B cell gene expression by enabling the interaction of PAX5 with the MLL H3K4 methyltransferase complex. Bullerwell CE, Robichaud PP, Deprez PML, Joy AP, Wajnberg G, D'Souza D, Chacko S, Fournier S, Crapoulet N, Barnett DA, Lewis SM, Ouellette RJ. Sci Rep. 2021 Jan 15;11(1):1537. doi: 10.1038/s41598-021-81000-5. PubMed |
| Deletion of Cbl-b inhibits CD8(+) T-cell exhaustion and promotes CAR T-cell function. Kumar J, Kumar R, Kumar Singh A, Tsakem EL, Kathania M, Riese MJ, Theiss AL, Davila ML, Venuprasad K. J Immunother Cancer. 2021 Jan;9(1). pii: jitc-2020-001688. doi: 10.1136/jitc-2020-001688. PubMed |
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CRNKL1 Is a Highly Selective Regulator of Intron-Retaining HIV-1 and Cellular mRNAs.
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| Direct control of store-operated calcium channels by ultrafast laser. Cheng P, Tian X, Tang W, Cheng J, Bao J, Wang H, Zheng S, Wang Y, Wei X, Chen T, Feng H, Xue T, Goda K, He H. Cell Res. 2021 Jan 19. pii: 10.1038/s41422-020-00463-9. doi: 10.1038/s41422-020-00463-9. PubMed |
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| A genome-wide CRISPR/Cas9 screen in acute myeloid leukemia cells identifies regulators of TAK-243 sensitivity. Barghout SH, Aman A, Nouri K, Blatman Z, Arevalo K, Thomas GE, MacLean N, Hurren R, Ketela T, Saini M, Abohawya M, Kiyota T, Al-Awar R, Schimmer AD. JCI Insight. 2021 Mar 8;6(5). pii: 141518. doi: 10.1172/jci.insight.141518. PubMed |
| The RNA helicase Dhx15 mediates Wnt-induced antimicrobial protein expression in Paneth cells. Wang Y, He K, Sheng B, Lei X, Tao W, Zhu X, Wei Z, Fu R, Wang A, Bai S, Zhang Z, Hong N, Ye C, Tian Y, Wang J, Li M, Zhang K, Li L, Yang H, Li HB, Flavell RA, Zhu S. Proc Natl Acad Sci U S A. 2021 Jan 26;118(4). pii: 2017432118. doi: 10.1073/pnas.2017432118. PubMed |
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| Loss of G-Protein Pathway Suppressor 2 Promotes Tumor Growth Through Activation of AKT Signaling. Chan S, Smith E, Gao Y, Kwan J, Blum BC, Tilston-Lunel AM, Turcinovic I, Varelas X, Cardamone MD, Monti S, Emili A, Perissi V. Front Cell Dev Biol. 2021 Jan 7;8:608044. doi: 10.3389/fcell.2020.608044. eCollection 2020. PubMed |
| PRPS1-mediated purine biosynthesis is critical for pluripotent stem cell survival and stemness. Yang Y, Song L, Huang X, Feng Y, Zhang Y, Liu Y, Li S, Zhan Z, Zheng L, Feng H, Li Y. Aging (Albany NY). 2021 Jan 20;13(3):4063-4078. doi: 10.18632/aging.202372. Epub 2021 Jan 20. PubMed |
| G protein betagamma translocation to the Golgi apparatus activates MAPK via p110gamma-p101 heterodimers. Khater M, Wei Z, Xu X, Huang W, Lokeshwar BL, Lambert NA, Wu G. J Biol Chem. 2021 Jan-Jun;296:100325. doi: 10.1016/j.jbc.2021.100325. Epub 2021 Jan 23. PubMed |
| Tumor-suppressor function of Beclin 1 in breast cancer cells requires E-cadherin. Wijshake T, Zou Z, Chen B, Zhong L, Xiao G, Xie Y, Doench JG, Bennett L, Levine B. Proc Natl Acad Sci U S A. 2021 Feb 2;118(5). pii: 2020478118. doi: 10.1073/pnas.2020478118. PubMed |
| Genome-wide CRISPR screens reveal a specific ligand for the glycan-binding immune checkpoint receptor Siglec-7. Wisnovsky S, Mockl L, Malaker SA, Pedram K, Hess GT, Riley NM, Gray MA, Smith BAH, Bassik MC, Moerner WE, Bertozzi CR. Proc Natl Acad Sci U S A. 2021 Feb 2;118(5). pii: 2015024118. doi: 10.1073/pnas.2015024118. PubMed |
| Cdk5rap3 is essential for intestinal Paneth cell development and maintenance. Quintero M, Liu S, Xia Y, Huang Y, Zou Y, Li G, Hu L, Singh N, Blumberg R, Cai Y, Xu H, Li H. Cell Death Dis. 2021 Jan 27;12(1):131. doi: 10.1038/s41419-021-03401-8. PubMed |
| Genome-scale CRISPR screening for modifiers of cellular LDL uptake. Emmer BT, Sherman EJ, Lascuna PJ, Graham SE, Willer CJ, Ginsburg D. PLoS Genet. 2021 Jan 29;17(1):e1009285. doi: 10.1371/journal.pgen.1009285. eCollection 2021 Jan. PubMed |
| PTEN is required for the migration and invasion of Ras-transformed MDCK cells. Yan L, Tsujita K, Fujita Y, Itoh T. FEBS Lett. 2021 May;595(9):1303-1312. doi: 10.1002/1873-3468.14053. Epub 2021 Feb 20. PubMed |
| Cooperative Blockade of CK2 and ATM Kinases Drives Apoptosis in VHL-Deficient Renal Carcinoma Cells through ROS Overproduction. Giacosa S, Pillet C, Seraudie I, Guyon L, Wallez Y, Roelants C, Battail C, Evrard B, Chalmel F, Barette C, Soleilhac E, Fauvarque MO, Franquet Q, Sarrazin C, Peilleron N, Fiard G, Long JA, Descotes JL, Cochet C, Filhol O. Cancers (Basel). 2021 Feb 2;13(3). pii: cancers13030576. doi: 10.3390/cancers13030576. PubMed |
| Auto-antibodies to type I IFNs can underlie adverse reactions to yellow fever live attenuated vaccine. Bastard P, Michailidis E, Hoffmann HH, Chbihi M, Le Voyer T, Rosain J, Philippot Q, Seeleuthner Y, Gervais A, Materna M, de Oliveira PMN, Maia MLS, Dinis Ano Bom AP, Azamor T, Araujo da Conceicao D, Goudouris E, Homma A, Slesak G, Schafer J, Pulendran B, Miller JD, Huits R, Yang R, Rosen LB, Bizien L, Lorenzo L, Chrabieh M, Erazo LV, Rozenberg F, Jeljeli MM, Beziat V, Holland SM, Cobat A, Notarangelo LD, Su HC, Ahmed R, Puel A, Zhang SY, Abel L, Seligman SJ, Zhang Q, MacDonald MR, Jouanguy E, Rice CM, Casanova JL. J Exp Med. 2021 Apr 5;218(4). pii: 211761. doi: 10.1084/jem.20202486. PubMed |
| Optimized protocol for gene editing in adipocytes using CRISPR-Cas9 technology. Qiu Y, Ding Q. STAR Protoc. 2021 Jan 27;2(1):100307. doi: 10.1016/j.xpro.2021.100307. eCollection 2021 Mar 19. PubMed |
| Acute Kidney Injury Instigates Malignant Renal Cell Carcinoma via CXCR2 in Mice with Inactivated Trp53 and Pten in Proximal Tubular Kidney Epithelial Cells. Zhou X, Xiao F, Sugimoto H, Li B, McAndrews KM, Kalluri R. Cancer Res. 2021 May 15;81(10):2690-2702. doi: 10.1158/0008-5472.CAN-20-2930. Epub 2021 Feb 8. PubMed |
| AKT1-CREB stimulation of PDGFRalpha expression is pivotal for PTEN deficient tumor development. Wan X, Zhou M, Huang F, Zhao N, Chen X, Wu Y, Zhu W, Ni Z, Jin F, Wang Y, Hu Z, Chen X, Ren M, Zhang H, Zha X. Cell Death Dis. 2021 Feb 10;12(2):172. doi: 10.1038/s41419-021-03433-0. PubMed |
| Small molecule inhibitor of OGG1 blocks oxidative DNA damage repair at telomeres and potentiates methotrexate anticancer effects. Baquero JM, Benitez-Buelga C, Rajagopal V, Zhenjun Z, Torres-Ruiz R, Muller S, Hanna BMF, Loseva O, Wallner O, Michel M, Rodriguez-Perales S, Gad H, Visnes T, Helleday T, Benitez J, Osorio A. Sci Rep. 2021 Feb 10;11(1):3490. doi: 10.1038/s41598-021-82917-7. PubMed |
| Genome-wide CRISPR-Cas9 screen identified KLF11 as a druggable suppressor for sarcoma cancer stem cells. Wang Y, Wu J, Chen H, Yang Y, Xiao C, Yi X, Shi C, Zhong K, He H, Li Y, Wu Z, Zhou G, Rao Q, Wang X, Zhou X, Lomberk G, Liu B, Zhao J, Ge J, Zhou W, Chu X, Chen C, Zhou X, Wang L, Guan K, Qu L. Sci Adv. 2021 Jan 27;7(5). pii: 7/5/eabe3445. doi: 10.1126/sciadv.abe3445. Print 2021 Jan. PubMed |
| A genome-wide CRISPR screen identifies host factors that regulate SARS-CoV-2 entry. Zhu Y, Feng F, Hu G, Wang Y, Yu Y, Zhu Y, Xu W, Cai X, Sun Z, Han W, Ye R, Qu D, Ding Q, Huang X, Chen H, Xu W, Xie Y, Cai Q, Yuan Z, Zhang R. Nat Commun. 2021 Feb 11;12(1):961. doi: 10.1038/s41467-021-21213-4. PubMed |
| NRAS is unique among RAS proteins in requiring ICMT for trafficking to the plasma membrane. Ahearn IM, Court HR, Siddiqui F, Abankwa D, Philips MR. Life Sci Alliance. 2021 Feb 12;4(5). pii: 4/5/e202000972. doi: 10.26508/lsa.202000972. Print 2021 May. PubMed |
| Identification of MFGE8 and KLK5/7 as mediators of breast tumorigenesis and resistance to COX-2 inhibition. Tian J, Wang V, Wang N, Khadang B, Boudreault J, Bakdounes K, Ali S, Lebrun JJ. Breast Cancer Res. 2021 Feb 15;23(1):23. doi: 10.1186/s13058-021-01401-2. PubMed |
| Palladin isoforms 3 and 4 regulate cancer-associated fibroblast pro-tumor functions in pancreatic ductal adenocarcinoma. Alexander JI, Vendramini-Costa DB, Francescone R, Luong T, Franco-Barraza J, Shah N, Gardiner JC, Nicolas E, Raghavan KS, Cukierman E. Sci Rep. 2021 Feb 15;11(1):3802. doi: 10.1038/s41598-021-82937-3. PubMed |
| Schlafen 11 is a novel target for mucosal regeneration in Ulcerative Colitis. Watanabe S, Nishimura R, Shirasaki T, Katsukura N, Hibiya S, Kirimura S, Negi M, Okamoto R, Matsumoto Y, Nakamura T, Watanabe M, Tsuchiya K. J Crohns Colitis. 2021 Feb 17. pii: 6141476. doi: 10.1093/ecco-jcc/jjab032. PubMed |
| Cancer-associated exportin-6 upregulation inhibits the transcriptionally repressive and anticancer effects of nuclear profilin-1. Zhu C, Kim SJ, Mooradian A, Wang F, Li Z, Holohan S, Collins PL, Wang K, Guo Z, Hoog J, Ma CX, Oltz EM, Held JM, Shao J. Cell Rep. 2021 Feb 16;34(7):108749. doi: 10.1016/j.celrep.2021.108749. PubMed |
| Genome-scale chemogenomic CRISPR screens in human cells using the TKOv3 library. Olivieri M, Durocher D. STAR Protoc. 2021 Feb 5;2(1):100321. doi: 10.1016/j.xpro.2021.100321. eCollection 2021 Mar 19. PubMed |
| Autophagy buffers Ras-induced genotoxic stress enabling malignant transformation in keratinocytes primed by human papillomavirus. Cararo-Lopes E, Dias MH, da Silva MS, Zeidler JD, Vessoni AT, Reis MS, Boccardo E, Armelin HA. Cell Death Dis. 2021 Feb 18;12(2):194. doi: 10.1038/s41419-021-03476-3. PubMed |
| Genome-wide CRISPR/Cas9-knockout in human induced Pluripotent Stem Cell (iPSC)-derived macrophages. Navarro-Guerrero E, Tay C, Whalley JP, Cowley SA, Davies B, Knight JC, Ebner D. Sci Rep. 2021 Feb 19;11(1):4245. doi: 10.1038/s41598-021-82137-z. PubMed |
| SEC24A facilitates colocalization and Ca(2) (+) flux between the endoplasmic reticulum and mitochondria. Chidawanyika T, Chakrabarti R, Beauchemin KS, Higgs HN, Supattapone S. J Cell Sci. 2021 Mar 26;134(6). pii: jcs.249276. doi: 10.1242/jcs.249276. PubMed |
| PAF remodels the DREAM complex to bypass cell quiescence and promote lung tumorigenesis. Kim MJ, Cervantes C, Jung YS, Zhang X, Zhang J, Lee SH, Jun S, Litovchick L, Wang W, Chen J, Fang B, Park JI. Mol Cell. 2021 Apr 15;81(8):1698-1714.e6. doi: 10.1016/j.molcel.2021.02.001. Epub 2021 Feb 23. PubMed |
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| HLA-G and HLA-E Immune Checkpoints Are Widely Expressed in Ewing Sarcoma but Have Limited Functional Impact on the Effector Functions of Antigen-Specific CAR T Cells. Altvater B, Kailayangiri S, Perez Lanuza LF, Urban K, Greune L, Flugge M, Meltzer J, Farwick N, Konig S, Gorlich D, Hartmann W, Rossig C. Cancers (Basel). 2021 Jun 8;13(12). pii: cancers13122857. doi: 10.3390/cancers13122857. PubMed |
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| A Novel Biological Activity of the STAT3 Inhibitor Stattic in Inhibiting Glutathione Reductase and Suppressing the Tumorigenicity of Human Cervical Cancer Cells via a ROS-Dependent Pathway. Xia Y, Wang G, Jiang M, Liu X, Zhao Y, Song Y, Jiang B, Zhu D, Hu L, Zhang Z, Cao T, Wang JM, Hu J. Onco Targets Ther. 2021 Jul 5;14:4047-4060. doi: 10.2147/OTT.S313507. eCollection 2021. PubMed |
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Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9.
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PubMed
Associated Plasmids |
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| AIM2 Suppresses Inflammation and Epithelial Cell Proliferation during Glomerulonephritis. Chung H, Komada T, Lau A, Chappellaz M, Platnich JM, de Koning HD, Petri B, Luque Y, Walker S, Benediktsson H, Mesnard L, Chun J, Muruve DA. J Immunol. 2021 Dec 1;207(11):2799-2812. doi: 10.4049/jimmunol.2100483. Epub 2021 Nov 5. PubMed |
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| TIAM1-RAC1 promote small-cell lung cancer cell survival through antagonizing Nur77-induced BCL2 conformational change. Payapilly A, Guilbert R, Descamps T, White G, Magee P, Zhou C, Kerr A, Simpson KL, Blackhall F, Dive C, Malliri A. Cell Rep. 2021 Nov 9;37(6):109979. doi: 10.1016/j.celrep.2021.109979. PubMed |
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| HER2 + breast cancers evade anti-HER2 therapy via a switch in driver pathway. Smith AE, Ferraro E, Safonov A, Morales CB, Lahuerta EJA, Li Q, Kulick A, Ross D, Solit DB, de Stanchina E, Reis-Filho J, Rosen N, Arribas J, Razavi P, Chandarlapaty S. Nat Commun. 2021 Nov 18;12(1):6667. doi: 10.1038/s41467-021-27093-y. PubMed |
| Nuclear dengue virus NS5 antagonizes expression of PAF1-dependent immune response genes. Petit MJ, Kenaston MW, Pham OH, Nagainis AA, Fishburn AT, Shah PS. PLoS Pathog. 2021 Nov 19;17(11):e1010100. doi: 10.1371/journal.ppat.1010100. eCollection 2021 Nov. PubMed |
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| beta2SP/TET2 complex regulates gene 5hmC modification after cerebral ischemia. Ma X, Zhang M, Yan R, Wu H, Yang B, Miao Z. J Cell Mol Med. 2021 Dec;25(24):11300-11309. doi: 10.1111/jcmm.17060. Epub 2021 Nov 19. PubMed |
| Cullin3 deficiency shapes tumor microenvironment and promotes cholangiocarcinoma in liver-specific Smad4/Pten mutant mice. Zhao M, Quan Y, Zeng J, Lyu X, Wang H, Lei JH, Feng Y, Xu J, Chen Q, Sun H, Xu X, Lu L, Deng CX. Int J Biol Sci. 2021 Oct 11;17(15):4176-4191. doi: 10.7150/ijbs.67379. eCollection 2021. PubMed |
| PALP: A rapid imaging technique for stratifying ferroptosis sensitivity in normal and tumor tissues in situ. Wang F, Graham ET, Naowarojna N, Shi Z, Wang Y, Xie G, Zhou L, Salmon W, Jia JM, Wang X, Huang Y, Schreiber SL, Zou Y. Cell Chem Biol. 2022 Jan 20;29(1):157-170.e6. doi: 10.1016/j.chembiol.2021.11.001. Epub 2021 Nov 22. PubMed |
| Dissecting the heterogeneity and tumorigenesis of BRCA1 deficient mammary tumors via single cell RNA sequencing. Sun H, Zeng J, Miao Z, Lei KC, Huang C, Hu L, Su SM, Chan UI, Miao K, Zhang X, Zhang A, Guo S, Chen S, Meng Y, Deng M, Hao W, Lei H, Lin Y, Yang Z, Tang D, Wong KH, Zhang XD, Xu X, Deng CX. Theranostics. 2021 Oct 25;11(20):9967-9987. doi: 10.7150/thno.63995. eCollection 2021. PubMed |
| LSD1 inhibition sustains T cell invigoration with a durable response to PD-1 blockade. Liu Y, Debo B, Li M, Shi Z, Sheng W, Shi Y. Nat Commun. 2021 Nov 24;12(1):6831. doi: 10.1038/s41467-021-27179-7. PubMed |
| Inhibition of USP14 influences alphaherpesvirus proliferation by degrading viral VP16 protein via ER stress-triggered selective autophagy. Ming SL, Zhang S, Wang Q, Zeng L, Zhou LY, Wang MD, Ma YX, Han LQ, Zhong K, Zhu HS, Bai YL, Yang GY, Wang J, Chu BB. Autophagy. 2021 Nov 25:1-21. doi: 10.1080/15548627.2021.2002101. PubMed |
| Development of a BCL-xL and BCL-2 dual degrader with improved anti-leukemic activity. Lv D, Pal P, Liu X, Jia Y, Thummuri D, Zhang P, Hu W, Pei J, Zhang Q, Zhou S, Khan S, Zhang X, Hua N, Yang Q, Arango S, Zhang W, Nayak D, Olsen SK, Weintraub ST, Hromas R, Konopleva M, Yuan Y, Zheng G, Zhou D. Nat Commun. 2021 Nov 25;12(1):6896. doi: 10.1038/s41467-021-27210-x. PubMed |
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| Comprehensive Analysis of microRNAs in Human Adult Erythropoiesis. Nath A, Rayabaram J, Ijee S, Bagchi A, Chaudhury AD, Roy D, Chambayil K, Singh J, Nakamura Y, Velayudhan SR. Cells. 2021 Nov 4;10(11). pii: cells10113018. doi: 10.3390/cells10113018. PubMed |
| Identification of Cellular Factors Required for SARS-CoV-2 Replication. Synowiec A, Jedrysik M, Branicki W, Klajmon A, Lei J, Owczarek K, Suo C, Szczepanski A, Wang J, Zhang P, Labaj PP, Pyrc K. Cells. 2021 Nov 13;10(11). pii: cells10113159. doi: 10.3390/cells10113159. PubMed |
| Regulation of PP2A, PP4, and PP6 holoenzyme assembly by carboxyl-terminal methylation. Lyons SP, Greiner EC, Cressey LE, Adamo ME, Kettenbach AN. Sci Rep. 2021 Nov 29;11(1):23031. doi: 10.1038/s41598-021-02456-z. PubMed |
| The SETDB1-TRIM28 Complex Suppresses Antitumor Immunity. Lin J, Guo D, Liu H, Zhou W, Wang C, Muller I, Kossenkov AV, Drapkin R, Bitler BG, Helin K, Zhang R. Cancer Immunol Res. 2021 Dec;9(12):1413-1424. doi: 10.1158/2326-6066.CIR-21-0754. PubMed |
| Downregulation of SFRP2 facilitates cancer stemness and radioresistance of glioma cells via activating Wnt/beta-catenin signaling. Wu Q, Yin X, Zhao W, Xu W, Chen L. PLoS One. 2021 Dec 1;16(12):e0260864. doi: 10.1371/journal.pone.0260864. eCollection 2021. PubMed |
| CHK1 protects oncogenic KRAS-expressing cells from DNA damage and is a target for pancreatic cancer treatment. Klomp JE, Lee YS, Goodwin CM, Papke B, Klomp JA, Waters AM, Stalnecker CA, DeLiberty JM, Drizyte-Miller K, Yang R, Diehl JN, Yin HH, Pierobon M, Baldelli E, Ryan MB, Li S, Peterson J, Smith AR, Neal JT, McCormick AK, Kuo CJ, Counter CM, Petricoin EF 3rd, Cox AD, Bryant KL, Der CJ. Cell Rep. 2021 Nov 30;37(9):110060. doi: 10.1016/j.celrep.2021.110060. PubMed |
| PRDX-1 Supports the Survival and Antitumor Activity of Primary and CAR-Modified NK Cells under Oxidative Stress. Klopotowska M, Bajor M, Graczyk-Jarzynka A, Kraft A, Pilch Z, Zhylko A, Firczuk M, Baranowska I, Lazniewski M, Plewczynski D, Goral A, Soroczynska K, Domagala J, Marhelava K, Slusarczyk A, Retecki K, Ramji K, Krawczyk M, Temples MN, Sharma B, Lachota M, Netskar H, Malmberg KJ, Zagozdzon R, Winiarska M. Cancer Immunol Res. 2022 Feb;10(2):228-244. doi: 10.1158/2326-6066.CIR-20-1023. Epub 2021 Dec 1. PubMed |
| Tumor evolution selectively inactivates the core microRNA machinery for immune evasion. Song TY, Long M, Zhao HX, Zou MW, Fan HJ, Liu Y, Geng CL, Song MF, Liu YF, Chen JY, Yang YL, Zhou WR, Huang DW, Peng B, Peng ZG, Cang Y. Nat Commun. 2021 Dec 1;12(1):7003. doi: 10.1038/s41467-021-27331-3. PubMed |
| Cross-species analysis of viral nucleic acid interacting proteins identifies TAOKs as innate immune regulators. Pennemann FL, Mussabekova A, Urban C, Stukalov A, Andersen LL, Grass V, Lavacca TM, Holze C, Oubraham L, Benamrouche Y, Girardi E, Boulos RE, Hartmann R, Superti-Furga G, Habjan M, Imler JL, Meignin C, Pichlmair A. Nat Commun. 2021 Dec 1;12(1):7009. doi: 10.1038/s41467-021-27192-w. PubMed |
| A novel RNA-mediated mechanism causing down-regulation of insulating promoter interactions in human embryonic stem cells. Liu Y, Williams SG, Jones HR, Keavney BD, Choy MK. Sci Rep. 2021 Dec 1;11(1):23233. doi: 10.1038/s41598-021-02373-1. PubMed |
| LS-106, a novel EGFR inhibitor targeting C797S, exhibits antitumor activities both in vitro and in vivo. Liu Y, Lai M, Li S, Wang Y, Feng F, Zhang T, Tong L, Zhang M, Chen H, Chen Y, Song P, Li Y, Bai G, Ning Y, Tang H, Fang Y, Chen Y, Lu X, Geng M, Ding K, Yu K, Xie H, Ding J. Cancer Sci. 2022 Feb;113(2):709-720. doi: 10.1111/cas.15229. Epub 2021 Dec 16. PubMed |
| AMBRA1 promotes dsRNA- and virus-induced apoptosis through interacting with and stabilizing MAVS. Lin Y, Huang C, Gao H, Li X, Lin Q, Zhou S, Huo Z, Huang Y, Liu C, Zhang P. J Cell Sci. 2022 Jan 1;135(1). pii: 273618. doi: 10.1242/jcs.258910. Epub 2022 Jan 7. PubMed |
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| RIPK1 dephosphorylation and kinase activation by PPP1R3G/PP1gamma promote apoptosis and necroptosis. Du J, Xiang Y, Liu H, Liu S, Kumar A, Xing C, Wang Z. Nat Commun. 2021 Dec 3;12(1):7067. doi: 10.1038/s41467-021-27367-5. PubMed |
| RSK1 SUMOylation is required for KSHV lytic replication. Liu Z, Liu C, Wang X, Li W, Zhou J, Dong P, Xiao MZX, Wang C, Zhang Y, Fu J, Zhu F, Liang Q. PLoS Pathog. 2021 Dec 6;17(12):e1010123. doi: 10.1371/journal.ppat.1010123. eCollection 2021 Dec. PubMed |
| Integrated stress response regulates GDF15 secretion from adipocytes, preferentially suppresses appetite for a high-fat diet and improves obesity. Miyake M, Zhang J, Yasue A, Hisanaga S, Tsugawa K, Sakaue H, Oyadomari M, Kiyonari H, Oyadomari S. iScience. 2021 Nov 15;24(12):103448. doi: 10.1016/j.isci.2021.103448. eCollection 2021 Dec 17. PubMed |
Integrated genome and tissue engineering enables screening of cancer vulnerabilities in physiologically relevant perfusable ex vivo cultures.
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| Hypoxia-induced Fascin-1 upregulation is regulated by Akt/Rac1 axis and enhances malignant properties of liver cancer cells via mediating actin cytoskeleton rearrangement and Hippo/YAP activation. Pu J, Huang Y, Fang Q, Wang J, Li W, Xu Z, Wu X, Lu Y, Wei H. Cell Death Discov. 2021 Dec 11;7(1):385. doi: 10.1038/s41420-021-00778-5. PubMed |
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Functional visualization of NK Cell-mediated killing of metastatic single tumor cells.
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| Pharmacological perturbation of CXCL1 signaling alleviates neuropathogenesis in a model of HEVA71 infection. Gunaseelan S, Ariffin MZ, Khanna S, Ooi MH, Perera D, Chu JJH, Chua JJE. Nat Commun. 2022 Feb 16;13(1):890. doi: 10.1038/s41467-022-28533-z. PubMed |
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| HOTTIP-dependent R-loop formation regulates CTCF boundary activity and TAD integrity in leukemia. Luo H, Zhu G, Eshelman MA, Fung TK, Lai Q, Wang F, Zeisig BB, Lesperance J, Ma X, Chen S, Cesari N, Cogle C, Chen B, Xu B, Yang FC, So CWE, Qiu Y, Xu M, Huang S. Mol Cell. 2022 Feb 17;82(4):833-851.e11. doi: 10.1016/j.molcel.2022.01.014. PubMed |
| Genome wide CRISPR/Cas9 screen identifies the coagulation factor IX (F9) as a regulator of senescence. Carpintero-Fernandez P, Borghesan M, Eleftheriadou O, Pan-Castillo B, Fafian-Labora JA, Mitchell TP, Yuste A, Ogrunc M, Nightingale TD, Mayan M, O'Loghlen A. Cell Death Dis. 2022 Feb 19;13(2):163. doi: 10.1038/s41419-022-04569-3. PubMed |
| A peptide derived from the N-terminus of charged multivesicular body protein 6 (CHMP6) promotes the secretion of gene editing proteins via small extracellular vesicle production. Fan J, Pan J, Zhang X, Chen Y, Zeng Y, Huang L, Ma D, Chen Z, Wu G, Fan W. Bioengineered. 2022 Mar;13(3):4702-4716. doi: 10.1080/21655979.2022.2030571. PubMed |
| Vitamin D Receptor Activation Attenuates Hippo Pathway Effectors and Cell Survival in Metastatic Neuroblastoma. Ladumor Y, Seong BKA, Hallett R, Valencia-Sama I, Adderley T, Wang Y, Kee L, Gont A, Kaplan DR, Irwin MS. Mol Cancer Res. 2022 Jun 3;20(6):895-908. doi: 10.1158/1541-7786.MCR-21-0425. PubMed |
| Angiopoietin-like 4 promotes glucose metabolism by regulating glucose transporter expression in colorectal cancer. Mizuno S, Seishima R, Yamasaki J, Hattori K, Ogiri M, Matsui S, Shigeta K, Okabayashi K, Nagano O, Li L, Kitagawa Y. J Cancer Res Clin Oncol. 2022 Jun;148(6):1351-1361. doi: 10.1007/s00432-022-03960-z. Epub 2022 Feb 23. PubMed |
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| Hyperactivation of MAPK Induces Tamoxifen Resistance in SPRED2-Deficient ERalpha-Positive Breast Cancer. Vafeiadou V, Hany D, Picard D. Cancers (Basel). 2022 Feb 14;14(4):954. doi: 10.3390/cancers14040954. PubMed |
| The dual role of p62 in ferroptosis of glioblastoma according to p53 status. Yuan F, Sun Q, Zhang S, Ye L, Xu Y, Deng G, Xu Z, Zhang S, Liu B, Chen Q. Cell Biosci. 2022 Feb 25;12(1):20. doi: 10.1186/s13578-022-00764-z. PubMed |
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| Glycosylation-Dependent Induction of Programmed Cell Death in Murine Adenocarcinoma Cells. Parshenkov A, Hennet T. Front Immunol. 2022 Feb 10;13:797759. doi: 10.3389/fimmu.2022.797759. eCollection 2022. PubMed |
| PERK reprograms hematopoietic progenitor cells to direct tumor-promoting myelopoiesis in the spleen. Liu M, Wu C, Luo S, Hua Q, Chen HT, Weng Y, Xu J, Lin H, Wang L, Li J, Zhu L, Guo Z, Zhuang SM, Kang T, Zheng L. J Exp Med. 2022 Apr 4;219(4):e20211498. doi: 10.1084/jem.20211498. Epub 2022 Mar 10. PubMed |
| Immunoproteasome Activity in Chronic Lymphocytic Leukemia as a Target of the Immunoproteasome-Selective Inhibitors. Besse A, Kraus M, Mendez-Lopez M, Maurits E, Overkleeft HS, Driessen C, Besse L. Cells. 2022 Mar 1;11(5). pii: cells11050838. doi: 10.3390/cells11050838. PubMed |
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| BMAL1 moonlighting as a gatekeeper for LINE1 repression and cellular senescence in primates. Liang C, Ke Q, Liu Z, Ren J, Zhang W, Hu J, Wang Z, Chen H, Xia K, Lai X, Wang Q, Yang K, Li W, Wu Z, Wang C, Yan H, Jiang X, Ji Z, Ma M, Long X, Wang S, Wang H, Sun H, Belmonte JCI, Qu J, Xiang AP, Liu GH. Nucleic Acids Res. 2022 Apr 8;50(6):3323-3347. doi: 10.1093/nar/gkac146. PubMed |
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| ATR and CDK4/6 inhibition target the growth of methotrexate-resistant choriocarcinoma. Georgiou M, Ntavelou P, Stokes W, Roy R, Maher GJ, Stoilova T, Choo JAMY, Rakhit CP, Martins M, Ajuh P, Horowitz N, Berkowitz RS, Elias K, Seckl MJ, Pardo OE. Oncogene. 2022 Apr;41(18):2540-2554. doi: 10.1038/s41388-022-02251-8. Epub 2022 Mar 18. PubMed |
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| Fatty acid oxidation fuels glioblastoma radioresistance with CD47-mediated immune evasion. Jiang N, Xie B, Xiao W, Fan M, Xu S, Duan Y, Hamsafar Y, Evans AC, Huang J, Zhou W, Lin X, Ye N, Wanggou S, Chen W, Jing D, Fragoso RC, Dugger BN, Wilson PF, Coleman MA, Xia S, Li X, Sun LQ, Monjazeb AM, Wang A, Murphy WJ, Kung HJ, Lam KS, Chen HW, Li JJ. Nat Commun. 2022 Mar 21;13(1):1511. doi: 10.1038/s41467-022-29137-3. PubMed |
| Shear stress switches the association of endothelial enhancers from ETV/ETS to KLF transcription factor binding sites. Tsaryk R, Yucel N, Leonard EV, Diaz N, Bondareva O, Odenthal-Schnittler M, Arany Z, Vaquerizas JM, Schnittler H, Siekmann AF. Sci Rep. 2022 Mar 21;12(1):4795. doi: 10.1038/s41598-022-08645-8. PubMed |
| Sense-and-Respond Payload Delivery Using a Novel Antigen-Inducible Promoter Improves Suboptimal CAR-T Activation. Guo T, Ma D, Lu TK. ACS Synth Biol. 2022 Apr 15;11(4):1440-1453. doi: 10.1021/acssynbio.1c00236. Epub 2022 Mar 22. PubMed |
| A novel and efficient CD22 CAR-T therapy induced a robust antitumor effect in relapsed/refractory leukemia patients when combined with CD19 CAR-T treatment as a sequential therapy. Zhang Y, Li S, Wang Y, Lu Y, Xu Y, Rao Q, Wang H, Xing H, Tian Z, Tang K, Lv L, Wang M, Wang J. Exp Hematol Oncol. 2022 Mar 22;11(1):15. doi: 10.1186/s40164-022-00270-5. PubMed |
| 1alpha,25(OH)2D3 reverses exhaustion and enhances antitumor immunity of human cytotoxic T cells. Li P, Zhu X, Cao G, Wu R, Li K, Yuan W, Chen B, Sun G, Xia X, Zhang H, Wang X, Yin Z, Lu L, Gao Y. J Immunother Cancer. 2022 Mar;10(3). pii: jitc-2021-003477. doi: 10.1136/jitc-2021-003477. PubMed |
| Nuclear receptor activation shapes spatial genome organization essential for gene expression control: lessons learned from the vitamin D receptor. Warwick T, Schulz MH, Gilsbach R, Brandes RP, Seuter S. Nucleic Acids Res. 2022 Apr 22;50(7):3745-3763. doi: 10.1093/nar/gkac178. PubMed |
| A Comparative Transcriptomic Analysis Reveals That HSP90AB1 Is Involved in the Immune and Inflammatory Responses to Porcine Deltacoronavirus Infection. Zhao Y, Chen R, Xiao D, Zhang L, Song D, Wen Y, Wu R, Zhao Q, Du S, Wen X, Cao S, Huang X. Int J Mol Sci. 2022 Mar 18;23(6). pii: ijms23063280. doi: 10.3390/ijms23063280. PubMed |
| CRISPR activation screen identifies BCL-2 proteins and B3GNT2 as drivers of cancer resistance to T cell-mediated cytotoxicity. Joung J, Kirchgatterer PC, Singh A, Cho JH, Nety SP, Larson RC, Macrae RK, Deasy R, Tseng YY, Maus MV, Zhang F. Nat Commun. 2022 Mar 25;13(1):1606. doi: 10.1038/s41467-022-29205-8. PubMed |
| Loss of thymidine phosphorylase activity disrupts adipocyte differentiation and induces insulin-resistant lipoatrophic diabetes. Gautheron J, Lima L, Akinci B, Zammouri J, Auclair M, Ucar SK, Ozen S, Altay C, Bax BE, Nemazanyy I, Lenoir V, Prip-Buus C, Acquaviva-Bourdain C, Lascols O, Feve B, Vigouroux C, Noel E, Jeru I. BMC Med. 2022 Mar 28;20(1):95. doi: 10.1186/s12916-022-02296-2. PubMed |
| CRISPR-Based Screening in Three-Dimensional Organoid Cultures to Identify TGF-beta Pathway Regulators. Frey N, Schwank G. Methods Mol Biol. 2022;2488:99-111. doi: 10.1007/978-1-0716-2277-3_8. PubMed |
Sensitivity of VHL mutant kidney cancers to HIF2 inhibitors does not require an intact p53 pathway.
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| In vivo imaging of microenvironmental and anti-PD-L1-mediated dynamics in cancer using S100A8/S100A9 as an imaging biomarker. Helfen A, Riess J, Fehler O, Stolting M, An Z, Kocman V, Schnepel A, Geyer C, Gerwing M, Masthoff M, Vogl T, Holtke C, Roth J, Ng T, Wildgruber M, Eisenblatter M. Neoplasia. 2022 Jun;28:100792. doi: 10.1016/j.neo.2022.100792. Epub 2022 Mar 31. PubMed |
| PRMT5 Interacting Partners and Substrates in Oligodendrocyte Lineage Cells. Dansu DK, Liang J, Selcen I, Zheng H, Moore DF, Casaccia P. Front Cell Neurosci. 2022 Mar 17;16:820226. doi: 10.3389/fncel.2022.820226. eCollection 2022. PubMed |
| A functional SNP rs895819 on pre-miR-27a is associated with bipolar disorder by targeting NCAM1. Yang Y, Lu W, Ning M, Zhou X, Wan X, Mi Q, Yang X, Zhang D, Zhang Y, Jiang B, He L, Liu J, Zou Y. Commun Biol. 2022 Apr 4;5(1):309. doi: 10.1038/s42003-022-03263-6. PubMed |
| Dual-gRNA approach with limited off-target effect corrects C9ORF72 repeat expansion in vivo. Piao X, Meng D, Zhang X, Song Q, Lv H, Jia Y. Sci Rep. 2022 Apr 5;12(1):5672. doi: 10.1038/s41598-022-07746-8. PubMed |
| STAG2 regulates interferon signaling in melanoma via enhancer loop reprogramming. Chu Z, Gu L, Hu Y, Zhang X, Li M, Chen J, Teng D, Huang M, Shen CH, Cai L, Yoshida T, Qi Y, Niu Z, Feng A, Geng S, Frederick DT, Specht E, Piris A, Sullivan RJ, Flaherty KT, Boland GM, Georgopoulos K, Liu D, Shi Y, Zheng B. Nat Commun. 2022 Apr 6;13(1):1859. doi: 10.1038/s41467-022-29541-9. PubMed |
| DELE1 tracks perturbed protein import and processing in human mitochondria. Fessler E, Krumwiede L, Jae LT. Nat Commun. 2022 Apr 6;13(1):1853. doi: 10.1038/s41467-022-29479-y. PubMed |
| Generation of a CHIP isogenic human iPSC-derived cortical neuron model for functional proteomics. Dias C, Nita E, Faktor J, Hernychova L, Kunath T, Ball KL. STAR Protoc. 2022 Apr 2;3(2):101247. doi: 10.1016/j.xpro.2022.101247. eCollection 2022 Jun 17. PubMed |
| Virally programmed extracellular vesicles sensitize cancer cells to oncolytic virus and small molecule therapy. Wedge ME, Jennings VA, Crupi MJF, Poutou J, Jamieson T, Pelin A, Pugliese G, de Souza CT, Petryk J, Laight BJ, Boileau M, Taha Z, Alluqmani N, McKay HE, Pikor L, Khan ST, Azad T, Rezaei R, Austin B, He X, Mansfield D, Rose E, Brown EEF, Crawford N, Alkayyal A, Surendran A, Singaravelu R, Roy DG, Migneco G, McSweeney B, Cottee ML, Jacobus EJ, Keller BA, Yamaguchi TN, Boutros PC, Geoffrion M, Rayner KJ, Chatterjee A, Auer RC, Diallo JS, Gibbings D, tenOever BR, Melcher A, Bell JC, Ilkow CS. Nat Commun. 2022 Apr 7;13(1):1898. doi: 10.1038/s41467-022-29526-8. PubMed |
| CHMP2A regulates tumor sensitivity to natural killer cell-mediated cytotoxicity. Bernareggi D, Xie Q, Prager BC, Yun J, Cruz LS, Pham TV, Kim W, Lee X, Coffey M, Zalfa C, Azmoon P, Zhu H, Tamayo P, Rich JN, Kaufman DS. Nat Commun. 2022 Apr 7;13(1):1899. doi: 10.1038/s41467-022-29469-0. PubMed |
| Tumor growth of neurofibromin-deficient cells is driven by decreased respiration and hampered by NAD(+) and SIRT3. Masgras I, Cannino G, Ciscato F, Sanchez-Martin C, Darvishi FB, Scantamburlo F, Pizzi M, Menga A, Fregona D, Castegna A, Rasola A. Cell Death Differ. 2022 Apr 7. pii: 10.1038/s41418-022-00991-4. doi: 10.1038/s41418-022-00991-4. PubMed |
| Swine Interferon-Inducible Transmembrane Proteins Potently Inhibit African Swine Fever Virus Replication. Cai S, Zheng Z, Cheng J, Zhong L, Shao R, Zheng F, Lai Z, Ou J, Xu L, Zhou P, Lu G, Zhang G. Front Immunol. 2022 Mar 25;13:827709. doi: 10.3389/fimmu.2022.827709. eCollection 2022. PubMed |
| Loss of KMT5C Promotes EGFR Inhibitor Resistance in NSCLC via LINC01510-Mediated Upregulation of MET. Pal AS, Agredo A, Lanman NA, Son J, Sohal IS, Bains M, Li C, Clingerman J, Gates K, Kasinski AL. Cancer Res. 2022 Apr 15;82(8):1534-1547. doi: 10.1158/0008-5472.CAN-20-0821. PubMed |
| FOXC1 Binds Enhancers and Promotes Cisplatin Resistance in Bladder Cancer. Lu YT, Xu T, Iqbal M, Hsieh TC, Luo Z, Liang G, Farnham PJ, Rhie SK, Goldkorn A. Cancers (Basel). 2022 Mar 28;14(7):1717. doi: 10.3390/cancers14071717. PubMed |
| Baicalein Activates Parkin-Dependent Mitophagy through NDP52 and OPTN. Ke PY, Chang CW, Hsiao YC. Cells. 2022 Mar 28;11(7). pii: cells11071132. doi: 10.3390/cells11071132. PubMed |
| Genome-wide CRISPR screen identifies PRC2 and KMT2D-COMPASS as regulators of distinct EMT trajectories that contribute differentially to metastasis. Zhang Y, Donaher JL, Das S, Li X, Reinhardt F, Krall JA, Lambert AW, Thiru P, Keys HR, Khan M, Hofree M, Wilson MM, Yedier-Bayram O, Lack NA, Onder TT, Bagci-Onder T, Tyler M, Tirosh I, Regev A, Lees JA, Weinberg RA. Nat Cell Biol. 2022 Apr;24(4):554-564. doi: 10.1038/s41556-022-00877-0. Epub 2022 Apr 11. PubMed |
| Mitolysosome exocytosis, a mitophagy-independent mitochondrial quality control in flunarizine-induced parkinsonism-like symptoms. Bao F, Zhou L, Zhou R, Huang Q, Chen J, Zeng S, Wu Y, Yang L, Qian S, Wang M, He X, Liang S, Qi J, Xiang G, Long Q, Guo J, Ying Z, Zhou Y, Zhao Q, Zhang J, Zhang D, Sun W, Gao M, Wu H, Zhao Y, Nie J, Li M, Chen Q, Chen J, Zhang X, Pan G, Zhang H, Li M, Tian M, Liu X. Sci Adv. 2022 Apr 15;8(15):eabk2376. doi: 10.1126/sciadv.abk2376. Epub 2022 Apr 13. PubMed |
| When killers become thieves: Trogocytosed PD-1 inhibits NK cells in cancer. Hasim MS, Marotel M, Hodgins JJ, Vulpis E, Makinson OJ, Asif S, Shih HY, Scheer AK, MacMillan O, Alonso FG, Burke KP, Cook DP, Li R, Petrucci MT, Santoni A, Fallon PG, Sharpe AH, Sciume G, Veillette A, Zingoni A, Gray DA, McCurdy A, Ardolino M. Sci Adv. 2022 Apr 15;8(15):eabj3286. doi: 10.1126/sciadv.abj3286. Epub 2022 Apr 13. PubMed |
| SLC35B2 Acts in a Dual Role in the Host Sulfation Required for EV71 Infection. Guo D, Yu X, Wang D, Li Z, Zhou Y, Xu G, Yuan B, Qin Y, Chen M. J Virol. 2022 May 11;96(9):e0204221. doi: 10.1128/jvi.02042-21. Epub 2022 Apr 14. PubMed |
| USP15 negatively regulates lung cancer progression through the TRAF6-BECN1 signaling axis for autophagy induction. Kim MJ, Min Y, Jeong SK, Son J, Kim JY, Lee JS, Kim DH, Lee JS, Chun E, Lee KY. Cell Death Dis. 2022 Apr 14;13(4):348. doi: 10.1038/s41419-022-04808-7. PubMed |
| Programme of self-reactive innate-like T cell-mediated cancer immunity. Chou C, Zhang X, Krishna C, Nixon BG, Dadi S, Capistrano KJ, Kansler ER, Steele M, Han J, Shyu A, Zhang J, Stamatiades EG, Liu M, Li S, Do MH, Edwards C, Kang DS, Chen CT, Wei IH, Pappou EP, Weiser MR, Garcia-Aguilar J, Smith JJ, Leslie CS, Li MO. Nature. 2022 May;605(7908):139-145. doi: 10.1038/s41586-022-04632-1. Epub 2022 Apr 20. PubMed |
| Mitochondrial dynamics regulate genome stability via control of caspase-dependent DNA damage. Cao K, Riley JS, Heilig R, Montes-Gomez AE, Vringer E, Berthenet K, Cloix C, Elmasry Y, Spiller DG, Ichim G, Campbell KJ, Gilmore AP, Tait SWG. Dev Cell. 2022 May 23;57(10):1211-1225.e6. doi: 10.1016/j.devcel.2022.03.019. Epub 2022 Apr 20. PubMed |
| Cellular abundance of sodium phosphate cotransporter SLC20A1/PiT1 and phosphate uptake are controlled post-transcriptionally by ESCRT. Zechner C, Henne WM, Sathe AA, Xing C, Hernandez G, Sun S, Cheong MC. J Biol Chem. 2022 Jun;298(6):101945. doi: 10.1016/j.jbc.2022.101945. Epub 2022 Apr 18. PubMed |
| PD-L1 signaling selectively regulates T cell lymphatic transendothelial migration. Piao W, Li L, Saxena V, Iyyathurai J, Lakhan R, Zhang Y, Lape IT, Paluskievicz C, Hippen KL, Lee Y, Silverman E, Shirkey MW, Riella LV, Blazar BR, Bromberg JS. Nat Commun. 2022 Apr 21;13(1):2176. doi: 10.1038/s41467-022-29930-0. PubMed |
| Rapid establishment of human colonic organoid knockout lines. Gu W, Colarusso JL, Dame MK, Spence JR, Zhou Q. STAR Protoc. 2022 Apr 12;3(2):101308. doi: 10.1016/j.xpro.2022.101308. eCollection 2022 Jun 17. PubMed |
| HOXB13 suppresses de novo lipogenesis through HDAC3-mediated epigenetic reprogramming in prostate cancer. Lu X, Fong KW, Gritsina G, Wang F, Baca SC, Brea LT, Berchuck JE, Spisak S, Ross J, Morrissey C, Corey E, Chandel NS, Catalona WJ, Yang X, Freedman ML, Zhao JC, Yu J. Nat Genet. 2022 May;54(5):670-683. doi: 10.1038/s41588-022-01045-8. Epub 2022 Apr 25. PubMed |
| Increased apoptotic sensitivity of glioblastoma enables therapeutic targeting by BH3-mimetics. Koessinger AL, Cloix C, Koessinger D, Heiland DH, Bock FJ, Strathdee K, Kinch K, Martinez-Escardo L, Paul NR, Nixon C, Malviya G, Jackson MR, Campbell KJ, Stevenson K, Davis S, Elmasry Y, Ahmed A, O'Prey J, Ichim G, Schnell O, Stewart W, Blyth K, Ryan KM, Chalmers AJ, Norman JC, Tait SWG. Cell Death Differ. 2022 Apr 26. pii: 10.1038/s41418-022-01001-3. doi: 10.1038/s41418-022-01001-3. PubMed |
| The immune checkpoint B7-H3 (CD276) regulates adipocyte progenitor metabolism and obesity development. Picarda E, Galbo PM Jr, Zong H, Rajan MR, Wallenius V, Zheng D, Borgeson E, Singh R, Pessin J, Zang X. Sci Adv. 2022 Apr 29;8(17):eabm7012. doi: 10.1126/sciadv.abm7012. Epub 2022 Apr 27. PubMed |
| ASCL1 activates neuronal stem cell-like lineage programming through remodeling of the chromatin landscape in prostate cancer. Nouruzi S, Ganguli D, Tabrizian N, Kobelev M, Sivak O, Namekawa T, Thaper D, Baca SC, Freedman ML, Aguda A, Davies A, Zoubeidi A. Nat Commun. 2022 Apr 27;13(1):2282. doi: 10.1038/s41467-022-29963-5. PubMed |
| Deficiency in coatomer complex I causes aberrant activation of STING signalling. Steiner A, Hrovat-Schaale K, Prigione I, Yu CH, Laohamonthonkul P, Harapas CR, Low RRJ, De Nardo D, Dagley LF, Mlodzianoski MJ, Rogers KL, Zillinger T, Hartmann G, Gantier MP, Gattorno M, Geyer M, Volpi S, Davidson S, Masters SL. Nat Commun. 2022 Apr 28;13(1):2321. doi: 10.1038/s41467-022-29946-6. PubMed |
| In vitro and in vivo assay of the ER lipid scramblase TMEM41B. Wu L, Liu L, Xu B, Huang D, Chen XW. STAR Protoc. 2022 Apr 19;3(2):101333. doi: 10.1016/j.xpro.2022.101333. eCollection 2022 Jun 17. PubMed |
| Identification of DAXX as a restriction factor of SARS-CoV-2 through a CRISPR/Cas9 screen. Mac Kain A, Maarifi G, Aicher SM, Arhel N, Baidaliuk A, Munier S, Donati F, Vallet T, Tran QD, Hardy A, Chazal M, Porrot F, OhAinle M, Carlson-Stevermer J, Oki J, Holden K, Zimmer G, Simon-Loriere E, Bruel T, Schwartz O, van der Werf S, Jouvenet N, Nisole S, Vignuzzi M, Roesch F. Nat Commun. 2022 May 4;13(1):2442. doi: 10.1038/s41467-022-30134-9. PubMed |
| Lymph node colonization induces tumor-immune tolerance to promote distant metastasis. Reticker-Flynn NE, Zhang W, Belk JA, Basto PA, Escalante NK, Pilarowski GOW, Bejnood A, Martins MM, Kenkel JA, Linde IL, Bagchi S, Yuan R, Chang S, Spitzer MH, Carmi Y, Cheng J, Tolentino LL, Choi O, Wu N, Kong CS, Gentles AJ, Sunwoo JB, Satpathy AT, Plevritis SK, Engleman EG. Cell. 2022 May 26;185(11):1924-1942.e23. doi: 10.1016/j.cell.2022.04.019. Epub 2022 May 6. PubMed |
| ADAM10 and ADAM17 promote SARS-CoV-2 cell entry and spike protein-mediated lung cell fusion. Jocher G, Grass V, Tschirner SK, Riepler L, Breimann S, Kaya T, Oelsner M, Hamad MS, Hofmann LI, Blobel CP, Schmidt-Weber CB, Gokce O, Jakwerth CA, Trimpert J, Kimpel J, Pichlmair A, Lichtenthaler SF. EMBO Rep. 2022 Jun 7;23(6):e54305. doi: 10.15252/embr.202154305. Epub 2022 May 8. PubMed |
| Hexokinase 3 enhances myeloid cell survival via non-glycolytic functions. Seiler K, Humbert M, Minder P, Mashimo I, Schlafli AM, Krauer D, Federzoni EA, Vu B, Moresco JJ, Yates JR 3rd, Sadowski MC, Radpour R, Kaufmann T, Sarry JE, Dengjel J, Tschan MP, Torbett BE. Cell Death Dis. 2022 May 11;13(5):448. doi: 10.1038/s41419-022-04891-w. PubMed |
| A genome-wide CRISPR-Cas9 knockout screen identifies essential and growth-restricting genes in human trophoblast stem cells. Dong C, Fu S, Karvas RM, Chew B, Fischer LA, Xing X, Harrison JK, Popli P, Kommagani R, Wang T, Zhang B, Theunissen TW. Nat Commun. 2022 May 10;13(1):2548. doi: 10.1038/s41467-022-30207-9. PubMed |
| FGFR2-BRD4 Axis Regulates Transcriptional Networks of Histone 3 Modification and Synergy Between Its Inhibitors and PD-1/PD-L1 in a TNBC Mouse Model. Lei JH, Zhang L, Wang Z, Peltier R, Xie Y, Chen G, Lin S, Miao K, Deng CX, Sun H. Front Immunol. 2022 Apr 25;13:861221. doi: 10.3389/fimmu.2022.861221. eCollection 2022. PubMed |
| P-Cadherin Regulates Intestinal Epithelial Cell Migration and Mucosal Repair, but Is Dispensable for Colitis Associated Colon Cancer. Naydenov NG, Lechuga S, Zalavadia A, Mukherjee PK, Gordon IO, Skvasik D, Vidovic P, Huang E, Rieder F, Ivanov AI. Cells. 2022 Apr 27;11(9). pii: cells11091467. doi: 10.3390/cells11091467. PubMed |
| Interferon regulatory factor 1 (IRF1) controls the metabolic programmes of low-grade pancreatic cancer cells. Alfarano G, Audano M, Di Chiaro P, Balestrieri C, Milan M, Polletti S, Spaggiari P, Zerbi A, Diaferia GR, Mitro N, Natoli G. Gut. 2023 Jan;72(1):109-128. doi: 10.1136/gutjnl-2021-325811. Epub 2022 May 13. PubMed |
| UNC45A deficiency causes microvillus inclusion disease-like phenotype by impairing myosin VB-dependent apical trafficking. Duclaux-Loras R, Lebreton C, Berthelet J, Charbit-Henrion F, Nicolle O, Revenu de Courtils C, Waich S, Valovka T, Khiat A, Rabant M, Racine C, Guerrera IC, Baptista J, Mahe MM, Hess MW, Durel B, Lefort N, Banal C, Parisot M, Talbotec C, Lacaille F, Ecochard-Dugelay E, Demir AM, Vogel GF, Faivre L, Rodrigues A, Fowler D, Janecke AR, Muller T, Huber LA, Rodrigues-Lima F, Ruemmele FM, Uhlig HH, Del Bene F, Michaux G, Cerf-Bensussan N, Parlato M. J Clin Invest. 2022 May 16;132(10). pii: 154997. doi: 10.1172/JCI154997. PubMed |
| A novel ATG5 interaction with Ku70 potentiates DNA repair upon genotoxic stress. Demirbag-Sarikaya S, Akkoc Y, Turgut S, Erbil-Bilir S, Kocaturk NM, Dengjel J, Gozuacik D. Sci Rep. 2022 May 17;12(1):8134. doi: 10.1038/s41598-022-11704-9. PubMed |
| A basement membrane discovery pipeline uncovers network complexity, regulators, and human disease associations. Jayadev R, Morais MRPT, Ellingford JM, Srinivasan S, Naylor RW, Lawless C, Li AS, Ingham JF, Hastie E, Chi Q, Fresquet M, Koudis NM, Thomas HB, O'Keefe RT, Williams E, Adamson A, Stuart HM, Banka S, Smedley D, Sherwood DR, Lennon R. Sci Adv. 2022 May 20;8(20):eabn2265. doi: 10.1126/sciadv.abn2265. Epub 2022 May 18. PubMed |
| The aspartyl protease DDI2 drives adaptation to proteasome inhibition in multiple myeloma. Op M, Ribeiro ST, Chavarria C, De Gassart A, Zaffalon L, Martinon F. Cell Death Dis. 2022 May 19;13(5):475. doi: 10.1038/s41419-022-04925-3. PubMed |
Multiplex base- and prime-editing with drive-and-process CRISPR arrays.
Yuan Q, Gao X.
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PubMed
Associated Plasmids |
| PRRX1 is a master transcription factor of stromal fibroblasts for myofibroblastic lineage progression. Lee KW, Yeo SY, Gong JR, Koo OJ, Sohn I, Lee WY, Kim HC, Yun SH, Cho YB, Choi MA, An S, Kim J, Sung CO, Cho KH, Kim SH. Nat Commun. 2022 May 19;13(1):2793. doi: 10.1038/s41467-022-30484-4. PubMed |
| Human NLRP1 is a sensor of pathogenic coronavirus 3CL proteases in lung epithelial cells. Planes R, Pinilla M, Santoni K, Hessel A, Passemar C, Lay K, Paillette P, Valadao AC, Robinson KS, Bastard P, Lam N, Fadrique R, Rossi I, Pericat D, Bagayoko S, Leon-Icaza SA, Rombouts Y, Perouzel E, Tiraby M, Zhang Q, Cicuta P, Jouanguy E, Neyrolles O, Bryant CE, Floto AR, Goujon C, Lei FZ, Martin-Blondel G, Silva S, Casanova JL, Cougoule C, Reversade B, Marcoux J, Ravet E, Meunier E. Mol Cell. 2022 Jul 7;82(13):2385-2400.e9. doi: 10.1016/j.molcel.2022.04.033. Epub 2022 May 16. PubMed |
| An IgM monoclonal antibody against domain 1 of CD147 induces non-canonical RIPK-independent necroptosis in a cell type specific manner in hepatocellular carcinoma cells. Pomlok K, Pata S, Kulaphisit M, Pangnuchar R, Wipasa J, Smith DR, Kasinrerk W, Lithanatudom P. Biochim Biophys Acta Mol Cell Res. 2022 Sep;1869(9):119295. doi: 10.1016/j.bbamcr.2022.119295. Epub 2022 May 19. PubMed |
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| Cooperation of Striatin 3 and MAP4K4 promotes growth and tissue invasion. Migliavacca J, Zullig B, Capdeville C, Grotzer MA, Baumgartner M. Commun Biol. 2022 Aug 8;5(1):795. doi: 10.1038/s42003-022-03708-y. PubMed |
| Prominin 1 and Notch regulate ciliary length and dynamics in multiciliated cells of the airway epithelium. Serra CFH, Liu H, Qian J, Mori M, Lu J, Cardoso WV. iScience. 2022 Jul 14;25(8):104751. doi: 10.1016/j.isci.2022.104751. eCollection 2022 Aug 19. PubMed |
Live Cell Detection of Poly(ADP-Ribose) for Use in Genetic and Genotoxic Compound Screens.
Koczor CA, Haider AJ, Saville KM, Li J, Andrews JF, Beiser AV, Sobol RW.
Cancers (Basel). 2022 Jul 28;14(15). pii: cancers14153676. doi: 10.3390/cancers14153676.
PubMed
Associated Plasmids |
| Relationship of microsatellite instability to mismatch repair deficiency in malignant tumors of dogs. Inanaga S, Igase M, Sakai Y, Hagimori K, Sunahara H, Horikirizono H, Itamoto K, Baba K, Ohsato Y, Mizuno T. J Vet Intern Med. 2022 Sep;36(5):1760-1769. doi: 10.1111/jvim.16454. Epub 2022 Aug 11. PubMed |
| XAF1 Protects Host against Emerging RNA Viruses by Stabilizing IRF1-Dependent Antiviral Immunity. Han Y, Bai X, Liu S, Zhu J, Zhang F, Xie L, Liu G, Jiang X, Zhang M, Huang Y, Wang J, Li D, Zhang H, He Y, He S, Xia Y, Xu X, Xu F, Ma F. J Virol. 2022 Sep 14;96(17):e0077422. doi: 10.1128/jvi.00774-22. Epub 2022 Aug 16. PubMed |
| Proximity labeling of endogenous RICTOR identifies mTOR complex 2 regulation by ADP ribosylation factor ARF1. Luciano AK, Korobkina ED, Lyons SP, Haley JA, Fluharty SM, Jung SM, Kettenbach AN, Guertin DA. J Biol Chem. 2022 Oct;298(10):102379. doi: 10.1016/j.jbc.2022.102379. Epub 2022 Aug 13. PubMed |
| BNIP-2 Activation of Cellular Contractility Inactivates YAP for H9c2 Cardiomyoblast Differentiation. Wong DCP, Xiao J, Chew TW, Pan M, Lee CJM, Ang JW, Yow I, Thivakar T, Ackers-Johnson M, Lee NJW, Foo RS, Kanchanawong P, Low BC. Adv Sci (Weinh). 2022 Nov;9(31):e2202834. doi: 10.1002/advs.202202834. Epub 2022 Aug 17. PubMed |
Direct control of lysosomal catabolic activity by mTORC1 through regulation of V-ATPase assembly.
Ratto E, Chowdhury SR, Siefert NS, Schneider M, Wittmann M, Helm D, Palm W.
Nat Commun. 2022 Aug 17;13(1):4848. doi: 10.1038/s41467-022-32515-6.
PubMed
Associated Plasmids |
| A C-terminal glutamine recognition mechanism revealed by E3 ligase TRIM7 structures. Liang X, Xiao J, Li X, Liu Y, Lu Y, Wen Y, Li Z, Che X, Ma Y, Zhang X, Zhang Y, Jian D, Wang P, Xuan C, Yu G, Li L, Zhang H. Nat Chem Biol. 2022 Nov;18(11):1214-1223. doi: 10.1038/s41589-022-01128-x. Epub 2022 Aug 18. PubMed |
| A novel IFNbeta-induced long non-coding RNA ZAP-IT1 interrupts Zika virus replication in A549 cells. Huang Y, Su Y, Shen L, Huo Z, Chen C, Sun T, Tian X, Li N, Yang C. Virol Sin. 2022 Dec;37(6):904-912. doi: 10.1016/j.virs.2022.08.003. Epub 2022 Aug 17. PubMed |
| Regulation of neuroendocrine plasticity by the RNA-binding protein ZFP36L1. Chen HY, Durmaz YT, Li Y, Sabet AH, Vajdi A, Denize T, Walton E, Laimon YN, Doench JG, Mahadevan NR, Losman JA, Barbie DA, Tolstorukov MY, Rudin CM, Sen T, Signoretti S, Oser MG. Nat Commun. 2022 Aug 25;13(1):4998. doi: 10.1038/s41467-022-31998-7. PubMed |
| GPT2 Is Induced by Hypoxia-Inducible Factor (HIF)-2 and Promotes Glioblastoma Growth. Zhang B, Chen Y, Bao L, Luo W. Cells. 2022 Aug 20;11(16):2597. doi: 10.3390/cells11162597. PubMed |
| IRF8 regulates efficacy of therapeutic anti-CD20 monoclonal antibodies. Grzelak L, Roesch F, Vaysse A, Biton A, Legendre R, Porrot F, Commere PH, Planchais C, Mouquet H, Vignuzzi M, Bruel T, Schwartz O. Eur J Immunol. 2022 Oct;52(10):1648-1661. doi: 10.1002/eji.202250037. Epub 2022 Sep 7. PubMed |
| Allele-specific silencing of the gain-of-function mutation in Huntington's disease using CRISPR/Cas9. Shin JW, Hong EP, Park SS, Choi DE, Seong IS, Whittaker MN, Kleinstiver BP, Chen RZ, Lee JM. JCI Insight. 2022 Oct 10;7(19):e141042. doi: 10.1172/jci.insight.141042. PubMed |
| Knockouts of TUT7 and 3'hExo show that they cooperate in histone mRNA maintenance and degradation. Holmquist CE, He W, Meganck RM, Marzluff WF. RNA. 2022 Nov;28(11):1519-1533. doi: 10.1261/rna.079233.122. Epub 2022 Aug 30. PubMed |
| RBM45 is an m(6)A-binding protein that affects neuronal differentiation and the splicing of a subset of mRNAs. Choi SH, Flamand MN, Liu B, Zhu H, Hu M, Wang M, Sewell J, Holley CL, Al-Hashimi HM, Meyer KD. Cell Rep. 2022 Aug 30;40(9):111293. doi: 10.1016/j.celrep.2022.111293. PubMed |
| Protein import motor complex reacts to mitochondrial misfolding by reducing protein import and activating mitophagy. Michaelis JB, Brunstein ME, Bozkurt S, Alves L, Wegner M, Kaulich M, Pohl C, Munch C. Nat Commun. 2022 Sep 2;13(1):5164. doi: 10.1038/s41467-022-32564-x. PubMed |
| Ectopic JAK-STAT activation enables the transition to a stem-like and multilineage state conferring AR-targeted therapy resistance. Deng S, Wang C, Wang Y, Xu Y, Li X, Johnson NA, Mukherji A, Lo UG, Xu L, Gonzalez J, Metang LA, Ye J, Tirado CR, Rodarte K, Zhou Y, Xie Z, Arana C, Annamalai V, Liu X, Vander Griend DJ, Strand D, Hsieh JT, Li B, Raj G, Wang T, Mu P. Nat Cancer. 2022 Sep;3(9):1071-1087. doi: 10.1038/s43018-022-00431-9. Epub 2022 Sep 5. PubMed |
| Pattern Recognition Receptors of Nucleic Acids Can Cause Sublethal Activation of the Mitochondrial Apoptosis Pathway during Viral Infection. Gradzka-Boberda S, Gentle IE, Hacker G. J Virol. 2022 Sep 28;96(18):e0121222. doi: 10.1128/jvi.01212-22. Epub 2022 Sep 7. PubMed |
| A phosphoinositide signalling pathway mediates rapid lysosomal repair. Tan JX, Finkel T. Nature. 2022 Sep;609(7928):815-821. doi: 10.1038/s41586-022-05164-4. Epub 2022 Sep 7. PubMed |
| NLRP3 leucine-rich repeats control induced and spontaneous inflammasome activation in cryopyrin-associated periodic syndrome. Theodoropoulou K, Spel L, Zaffalon L, Delacretaz M, Hofer M, Martinon F. J Allergy Clin Immunol. 2023 Jan;151(1):222-232.e9. doi: 10.1016/j.jaci.2022.08.019. Epub 2022 Sep 6. PubMed |
| Overexpression of nucleotide metabolic enzyme DUT in hepatocellular carcinoma potentiates a therapeutic opportunity through targeting its dUTPase activity. Xu M, Liu Y, Wan HL, Wong AM, Ding X, You W, Lo WS, Ng KK, Wong N. Cancer Lett. 2022 Nov 1;548:215898. doi: 10.1016/j.canlet.2022.215898. Epub 2022 Sep 6. PubMed |
| MAD2L2 promotes replication fork protection and recovery in a shieldin-independent and REV3L-dependent manner. Paniagua I, Tayeh Z, Falcone M, Hernandez Perez S, Cerutti A, Jacobs JJL. Nat Commun. 2022 Sep 8;13(1):5167. doi: 10.1038/s41467-022-32861-5. PubMed |
| Inhibition of Mcl-1 Synergistically Enhances the Antileukemic Activity of Gilteritinib and MRX-2843 in Preclinical Models of FLT3-Mutated Acute Myeloid Leukemia. Wu S, Edwards H, Wang D, Liu S, Qiao X, Carter J, Wang Y, Taub JW, Wang G, Ge Y. Cells. 2022 Sep 3;11(17):2752. doi: 10.3390/cells11172752. PubMed |
| Targeting of MCL-1 in breast cancer-associated fibroblasts reverses their myofibroblastic phenotype and pro-invasive properties. Bonneaud TL, Lefebvre CC, Nocquet L, Basseville A, Roul J, Weber H, Campone M, Juin PP, Souaze F. Cell Death Dis. 2022 Sep 14;13(9):787. doi: 10.1038/s41419-022-05214-9. PubMed |
| RETSAT associates with DDX39B to promote fork restarting and resistance to gemcitabine based chemotherapy in pancreatic ductal adenocarcinoma. Tu Q, Liu X, Yao X, Li R, Liu G, Jiang H, Li K, Chen Q, Huang X, Chang Q, Xu G, Zhu H, Shi P, Zhao B. J Exp Clin Cancer Res. 2022 Sep 15;41(1):274. doi: 10.1186/s13046-022-02490-3. PubMed |
| Knock-out of 5-lipoxygenase in overexpressing tumor cells-consequences on gene expression and cellular function. Weisser H, Gobel T, Melissa Krishnathas G, Kreiss M, Angioni C, Surun D, Thomas D, Schmid T, Hafner AK, Kahnt AS. Cancer Gene Ther. 2023 Jan;30(1):108-123. doi: 10.1038/s41417-022-00531-9. Epub 2022 Sep 16. PubMed |
| CRISPR-Cas9 screen in human embryonic stem cells to identify genes required for neural differentiation. Qi S, Sivakumar S, Yu H. STAR Protoc. 2022 Dec 16;3(4):101682. doi: 10.1016/j.xpro.2022.101682. Epub 2022 Sep 16. PubMed |
| Thiopurines inhibit coronavirus Spike protein processing and incorporation into progeny virions. Pringle ES, Duguay BA, Bui-Marinos MP, Mulloy RP, Landreth SL, Desireddy KS, Dolliver SM, Ying S, Caddell T, Tooley TH, Slaine PD, Bearne SL, Falzarano D, Corcoran JA, Khaperskyy DA, McCormick C. PLoS Pathog. 2022 Sep 19;18(9):e1010832. doi: 10.1371/journal.ppat.1010832. eCollection 2022 Sep. PubMed |
| Autophagy-linked plasma and lysosomal membrane protein PLAC8 is a key host factor for SARS-CoV-2 entry into human cells. Ugalde AP, Bretones G, Rodriguez D, Quesada V, Llorente F, Fernandez-Delgado R, Jimenez-Clavero MA, Vazquez J, Calvo E, Tamargo-Gomez I, Marino G, Roiz-Valle D, Maeso D, Araujo-Voces M, Espanol Y, Barcelo C, Freije JM, Lopez-Soto A, Lopez-Otin C. EMBO J. 2022 Nov 2;41(21):e110727. doi: 10.15252/embj.2022110727. Epub 2022 Oct 4. PubMed |
| Iron accelerates Fusobacterium nucleatum-induced CCL8 expression in macrophages and is associated with colorectal cancer progression. Yamane T, Kanamori Y, Sawayama H, Yano H, Nita A, Ohta Y, Hinokuma H, Maeda A, Iwai A, Matsumoto T, Shimoda M, Niimura M, Usuki S, Yasuda-Yoshihara N, Niwa M, Baba Y, Ishimoto T, Komohara Y, Sawa T, Hirayama T, Baba H, Moroishi T. JCI Insight. 2022 Nov 8;7(21):e156802. doi: 10.1172/jci.insight.156802. PubMed |
| Genome-Scale CRISPR Knockout Screening Identifies BACH1 as a Key Regulator of Aflatoxin B(1)-Induced Oxidative Damage. Zhang J, Hu S, Zhao C, Zhou Y, Zhang L, Liu H, Zhou P, Li S, Fu L, Zheng Z, Xiang Y, Xu X, Ruan J, Li X, Sun L, Cao G, Zhao S, Wang X, Xie S. Antioxidants (Basel). 2022 Sep 10;11(9):1787. doi: 10.3390/antiox11091787. PubMed |
| A novel oncogenic enhancer of estrogen receptor-positive breast cancer. Bao C, Duan J, Xie Y, Liu Y, Li P, Li J, Zhao H, Guo H, Men Y, Ren Y, Xu J, Wang G, Lu W. Mol Ther Nucleic Acids. 2022 Aug 24;29:836-851. doi: 10.1016/j.omtn.2022.08.029. eCollection 2022 Sep 13. PubMed |
Quantification of Genome Editing and Transcriptional Control Capabilities Reveals Hierarchies among Diverse CRISPR/Cas Systems in Human Cells.
Escobar M, Li J, Patel A, Liu S, Xu Q, Hilton IB.
ACS Synth Biol. 2022 Oct 21;11(10):3239-3250. doi: 10.1021/acssynbio.2c00156. Epub 2022 Sep 26.
PubMed
Associated Plasmids |
| De novo sphingolipid biosynthesis necessitates detoxification in cancer cells. Spears ME, Lee N, Hwang S, Park SJ, Carlisle AE, Li R, Doshi MB, Armando AM, Gao J, Simin K, Zhu LJ, Greer PL, Quehenberger O, Torres EM, Kim D. Cell Rep. 2022 Sep 27;40(13):111415. doi: 10.1016/j.celrep.2022.111415. PubMed |
| A cancer stem cell associated gene signature for predicting overall survival of hepatocellular carcinoma. Liang XY, Zhang Y, He YN, Liu XY, Ding ZH, Zhang XD, Dong MY, Du RL. Front Genet. 2022 Sep 12;13:888601. doi: 10.3389/fgene.2022.888601. eCollection 2022. PubMed |
| The proteomic landscape of glioblastoma recurrence reveals novel and targetable immunoregulatory drivers. Tatari N, Khan S, Livingstone J, Zhai K, Mckenna D, Ignatchenko V, Chokshi C, Gwynne WD, Singh M, Revill S, Mikolajewicz N, Zhu C, Chan J, Hawkins C, Lu JQ, Provias JP, Ask K, Morrissy S, Brown S, Weiss T, Weller M, Han H, Greenspoon JN, Moffat J, Venugopal C, Boutros PC, Singh SK, Kislinger T. Acta Neuropathol. 2022 Dec;144(6):1127-1142. doi: 10.1007/s00401-022-02506-4. Epub 2022 Sep 30. PubMed |
| MBD5 and MBD6 stabilize the BAP1 complex and promote BAP1-dependent cancer. Tsuboyama N, Szczepanski AP, Zhao Z, Wang L. Genome Biol. 2022 Sep 30;23(1):206. doi: 10.1186/s13059-022-02776-x. PubMed |
| Identifying an oligodendrocyte enhancer that regulates Olig2 expression. Fan C, Kim D, An H, Park Y. Hum Mol Genet. 2023 Feb 19;32(5):835-846. doi: 10.1093/hmg/ddac249. PubMed |
| NOTCH Signaling Limits the Response of Low-Grade Serous Ovarian Cancers to MEK Inhibition. Llaurado Fernandez M, Hijmans EM, Gennissen AMC, Wong NKY, Li S, Wisman GBA, Hamilton A, Hoenisch J, Dawson A, Lee CH, Bittner M, Kim H, DiMattia GE, Lok CAR, Lieftink C, Beijersbergen RL, de Jong S, Carey MS, Bernards R, Berns K. Mol Cancer Ther. 2022 Dec 2;21(12):1862-1874. doi: 10.1158/1535-7163.MCT-22-0004. PubMed |
| Lineage-coupled clonal capture identifies clonal evolution mechanisms and vulnerabilities of BRAF(V600E) inhibition resistance in melanoma. Zhang ZY, Ding Y, Ezhilarasan R, Lhakhang T, Wang Q, Yang J, Modrek AS, Zhang H, Tsirigos A, Futreal A, Draetta GF, Verhaak RGW, Sulman EP. Cell Discov. 2022 Oct 6;8(1):102. doi: 10.1038/s41421-022-00462-7. PubMed |
| Impaired expression of serine/arginine protein kinase 2 (SRPK2) affects melanoma progression. Caetano MMM, Moreira GA, da Silva MR, Guimaraes GR, Santos LO, Pacheco AA, Siqueira RP, Mendes FC, Marques Da Silva EA, Junior AS, Rangel Fietto JL, Saito A, Boroni M, Bressan GC. Front Genet. 2022 Sep 23;13:979735. doi: 10.3389/fgene.2022.979735. eCollection 2022. PubMed |
| A genome-wide screen identifies SCAI as a modulator of the UV-induced replicative stress response. Lemay JF, St-Hilaire E, Ronato DA, Gao Y, Belanger F, Gezzar-Dandashi S, Kimenyi Ishimwe AB, Sawchyn C, Levesque D, McQuaid M, Boisvert FM, Mallette FA, Masson JY, Drobetsky EA, Wurtele H. PLoS Biol. 2022 Oct 10;20(10):e3001543. doi: 10.1371/journal.pbio.3001543. eCollection 2022 Oct. PubMed |
| Lineage-selective super enhancers mediate core regulatory circuitry during adipogenic and osteogenic differentiation of human mesenchymal stem cells. Wang C, Tian W, Hu SY, Di CX, He CY, Cao QL, Hao RH, Dong SS, Liu CC, Rong Y, Kang HF, Yang TL, Yang Z, Guo Y. Cell Death Dis. 2022 Oct 12;13(10):866. doi: 10.1038/s41419-022-05309-3. PubMed |
| Targeting EGFR-dependent tumors by disrupting an ARF6-mediated sorting system. Guo H, Wang J, Ren S, Zheng LF, Zhuang YX, Li DL, Sun HH, Liu LY, Xie C, Wu YY, Wang HR, Deng X, Li P, Zhao TJ. Nat Commun. 2022 Oct 12;13(1):6004. doi: 10.1038/s41467-022-33788-7. PubMed |
| The Hippo pathway links adipocyte plasticity to adipose tissue fibrosis. Shen H, Huang X, Zhao Y, Wu D, Xue K, Yao J, Wang Y, Tang N, Qiu Y. Nat Commun. 2022 Oct 13;13(1):6030. doi: 10.1038/s41467-022-33800-0. PubMed |
| A novel protein RASON encoded by a lncRNA controls oncogenic RAS signaling in KRAS mutant cancers. Cheng R, Li F, Zhang M, Xia X, Wu J, Gao X, Zhou H, Zhang Z, Huang N, Yang X, Zhang Y, Shen S, Kang T, Liu Z, Xiao F, Yao H, Xu J, Yan C, Zhang N. Cell Res. 2023 Jan;33(1):30-45. doi: 10.1038/s41422-022-00726-7. Epub 2022 Oct 14. PubMed |
| ATF4-dependent fructolysis fuels growth of glioblastoma multiforme. Chen C, Zhang Z, Liu C, Wang B, Liu P, Fang S, Yang F, You Y, Li X. Nat Commun. 2022 Oct 16;13(1):6108. doi: 10.1038/s41467-022-33859-9. PubMed |
| miRNA mediated downregulation of cyclase-associated protein 1 (CAP1) is required for myoblast fusion. Singh AK, Rai A, Weber A, Posern G. Front Cell Dev Biol. 2022 Sep 30;10:899917. doi: 10.3389/fcell.2022.899917. eCollection 2022. PubMed |
| A local tumor microenvironment acquired super-enhancer induces an oncogenic driver in colorectal carcinoma. Zhou RW, Xu J, Martin TC, Zachem AL, He J, Ozturk S, Demircioglu D, Bansal A, Trotta AP, Giotti B, Gryder B, Shen Y, Wu X, Carcamo S, Bosch K, Hopkins B, Tsankov A, Steinhagen R, Jones DR, Asara J, Chipuk JE, Brody R, Itzkowitz S, Chio IIC, Hasson D, Bernstein E, Parsons RE. Nat Commun. 2022 Oct 17;13(1):6041. doi: 10.1038/s41467-022-33377-8. PubMed |
| CASK loss of function differentially regulates neuronal maturation and synaptic function in human induced cortical excitatory neurons. McSweeney D, Gabriel R, Jin K, Pang ZP, Aronow B, Pak C. iScience. 2022 Sep 23;25(10):105187. doi: 10.1016/j.isci.2022.105187. eCollection 2022 Oct 21. PubMed |
| Artesunate promoted anti-tumor immunity and overcame EGFR-TKI resistance in non-small-cell lung cancer by enhancing oncogenic TAZ degradation. Cao D, Chen D, Xia JN, Wang WY, Zhu GY, Chen LW, Zhang C, Tan B, Li H, Li YW. Biomed Pharmacother. 2022 Nov;155:113705. doi: 10.1016/j.biopha.2022.113705. Epub 2022 Oct 7. PubMed |
| A bovine antibody possessing an ultralong complementarity-determining region CDRH3 targets a highly conserved epitope in sarbecovirus spike proteins. Burke MJ, Scott JNF, Minshull TC, Gao Z, Manfield I, Savic S, Stockley PG, Calabrese AN, Boyes J. J Biol Chem. 2022 Dec;298(12):102624. doi: 10.1016/j.jbc.2022.102624. Epub 2022 Oct 20. PubMed |
| A pseudovirus-based platform to measure neutralizing antibodies in Mexico using SARS-CoV-2 as proof-of-concept. Cruz-Cardenas JA, Gutierrez M, Lopez-Arredondo A, Castaneda-Delgado JE, Rojas-Martinez A, Nakamura Y, Enciso-Moreno JA, Palomares LA, Brunck MEG. Sci Rep. 2022 Oct 26;12(1):17966. doi: 10.1038/s41598-022-22921-7. PubMed |
| Combinatorial gene targeting in primary human hematopoietic stem and progenitor cells. Backstrom A, Yudovich D, Zemaitis K, Nilsen Falck L, Subramaniam A, Larsson J. Sci Rep. 2022 Oct 28;12(1):18169. doi: 10.1038/s41598-022-23118-8. PubMed |
| Cellular Target Deconvolution of Small Molecules Using a Selection-Based Genetic Screening Platform. Zhao J, Tang Z, Selvaraju M, Johnson KA, Douglas JT, Gao PF, Petrassi HM, Wang MZ, Wang J. ACS Cent Sci. 2022 Oct 26;8(10):1424-1434. doi: 10.1021/acscentsci.2c00609. Epub 2022 Sep 22. PubMed |
Genome-wide base editor screen identifies regulators of protein abundance in yeast.
Schubert OT, Bloom JS, Sadhu MJ, Kruglyak L.
Elife. 2022 Nov 3;11. pii: 79525. doi: 10.7554/eLife.79525.
PubMed
Associated Plasmids |
| BRD9-containing non-canonical BAF complex maintains somatic cell transcriptome and acts as a barrier to human reprogramming. Sevinc K, Sevinc GG, Cavga AD, Philpott M, Kelekci S, Can H, Cribbs AP, Yildiz AB, Yilmaz A, Ayar ES, Arabaci DH, Dunford JE, Ata D, Sigua LH, Qi J, Oppermann U, Onder TT. Stem Cell Reports. 2022 Dec 13;17(12):2629-2642. doi: 10.1016/j.stemcr.2022.10.005. Epub 2022 Nov 3. PubMed |
| Site-specific CRISPR-based mitochondrial DNA manipulation is limited by gRNA import. Schmiderer L, Yudovich D, Oburoglu L, Hjort M, Larsson J. Sci Rep. 2022 Nov 4;12(1):18687. doi: 10.1038/s41598-022-21794-0. PubMed |
| Genome-wide CRISPR Screen Reveal Targets of Chiral Gold(I) Anticancer Compound in Mammalian Cells. Kim JH, Ofori S, Tagmount A, Vulpe CD, Awuah SG. ACS Omega. 2022 Oct 20;7(43):39197-39205. doi: 10.1021/acsomega.2c05166. eCollection 2022 Nov 1. PubMed |
| Tegument protein UL21 of alpha-herpesvirus inhibits the innate immunity by triggering CGAS degradation through TOLLIP-mediated selective autophagy. Ma Z, Bai J, Jiang C, Zhu H, Liu D, Pan M, Wang X, Pi J, Jiang P, Liu X. Autophagy. 2023 May;19(5):1512-1532. doi: 10.1080/15548627.2022.2139921. Epub 2022 Nov 7. PubMed |
| Discovery of a small molecule that selectively destabilizes Cryptochrome 1 and enhances life span in p53 knockout mice. Gul S, Akyel YK, Gul ZM, Isin S, Ozcan O, Korkmaz T, Selvi S, Danis I, Ipek OS, Aygenli F, Taskin AC, Akarlar BA, Ozlu N, Ozturk N, Ozturk N, Unal DO, Guzel M, Turkay M, Okyar A, Kavakli IH. Nat Commun. 2022 Nov 8;13(1):6742. doi: 10.1038/s41467-022-34582-1. PubMed |
| The MASTL/PP2A cell cycle kinase-phosphatase module restrains PI3K-Akt activity in an mTORC1-dependent manner. Sanz-Castillo B, Hurtado B, Vara-Ciruelos D, El Bakkali A, Hermida D, Salvador-Barbero B, Martinez-Alonso D, Gonzalez-Martinez J, Santiveri C, Campos-Olivas R, Ximenez-Embun P, Munoz J, Alvarez-Fernandez M, Malumbres M. EMBO J. 2023 Jan 16;42(2):e110833. doi: 10.15252/embj.2022110833. Epub 2022 Nov 10. PubMed |
| Novel protein complexes containing autophagy and UPS components regulate proteasome-dependent PARK2 recruitment onto mitochondria and PARK2-PARK6 activity during mitophagy. Kocaturk NM, Peker N, Eberhart K, Akkoc Y, Deveci G, Dengjel J, Gozuacik D. Cell Death Dis. 2022 Nov 10;13(11):947. doi: 10.1038/s41419-022-05339-x. PubMed |
| Arc controls alcohol cue relapse by a central amygdala mechanism. Pagano R, Salamian A, Zielinski J, Beroun A, Nalberczak-Skora M, Skonieczna E, Caly A, Tay N, Banaschewski T, Desrivieres S, Grigis A, Garavan H, Heinz A, Bruhl R, Martinot JL, Martinot MP, Artiges E, Nees F, Orfanos DP, Poustka L, Hohmann S, Frohner JH, Smolka MN, Vaidya N, Walter H, Whelan R, Kalita K, Bito H, Muller CP, Schumann G, Okuno H, Radwanska K. Mol Psychiatry. 2023 Feb;28(2):733-745. doi: 10.1038/s41380-022-01849-4. Epub 2022 Nov 10. PubMed |
| SARS-CoV-2 variant Alpha has a spike-dependent replication advantage over the ancestral B.1 strain in human cells with low ACE2 expression. Niemeyer D, Stenzel S, Veith T, Schroeder S, Friedmann K, Weege F, Trimpert J, Heinze J, Richter A, Jansen J, Emanuel J, Kazmierski J, Pott F, Jeworowski LM, Olmer R, Jaboreck MC, Tenner B, Papies J, Walper F, Schmidt ML, Heinemann N, Moncke-Buchner E, Baumgardt M, Hoffmann K, Widera M, Thao TTN, Balazs A, Schulze J, Mache C, Jones TC, Morkel M, Ciesek S, Hanitsch LG, Mall MA, Hocke AC, Thiel V, Osterrieder K, Wolff T, Martin U, Corman VM, Muller MA, Goffinet C, Drosten C. PLoS Biol. 2022 Nov 16;20(11):e3001871. doi: 10.1371/journal.pbio.3001871. eCollection 2022 Nov. PubMed |
| An mTORC1 to HRI signaling axis promotes cytotoxicity of proteasome inhibitors in multiple myeloma. Darawshi O, Muz B, Naamat SG, Praveen B, Mahameed M, Goldberg K, Dipta P, Shmuel M, Forno F, Boukeileh S, Pahima H, Hermann J, Raab MS, Poos AM, Weinhold N, Rosenbluh C, Gatt ME, Palm W, Azab AK, Tirosh B. Cell Death Dis. 2022 Nov 18;13(11):969. doi: 10.1038/s41419-022-05421-4. PubMed |
| MEK inhibitor resistance in lung adenocarcinoma is associated with addiction to sustained ERK suppression. Farnsworth DA, Inoue Y, Johnson FD, de Rappard-Yuswack G, Lu D, Shi R, Ma LIJ, Mattar MS, Somwar R, Ladanyi M, Unni AM, Lockwood WW. NPJ Precis Oncol. 2022 Nov 23;6(1):88. doi: 10.1038/s41698-022-00328-x. PubMed |
| Caspase-8 is required for HSV-1-induced apoptosis and promotes effective viral particle release via autophagy inhibition. Marino-Merlo F, Klett A, Papaianni E, Drago SFA, Macchi B, Rincon MG, Andreola F, Serafino A, Grelli S, Mastino A, Borner C. Cell Death Differ. 2023 Apr;30(4):885-896. doi: 10.1038/s41418-022-01084-y. Epub 2022 Nov 24. PubMed |
The Lack of STING Impairs the MHC-I Dependent Antigen Presentation and JAK/STAT Signaling in Murine Macrophages.
Caiazza C, Brusco T, D'Alessio F, D'Agostino M, Avagliano A, Arcucci A, Ambrosino C, Fiume G, Mallardo M.
Int J Mol Sci. 2022 Nov 17;23(22):14232. doi: 10.3390/ijms232214232.
PubMed
Associated Plasmids |
| Activation of orphan receptor GPR132 induces cell differentiation in acute myeloid leukemia. Yi C, He J, Huang D, Zhao Y, Zhang C, Ye X, Huang Y, Nussinov R, Zheng J, Liu M, Lu W. Cell Death Dis. 2022 Nov 27;13(11):1004. doi: 10.1038/s41419-022-05434-z. PubMed |
| The mitochondrial Cu(+) transporter PiC2 (SLC25A3) is a target of MTF1 and contributes to the development of skeletal muscle in vitro. McCann C, Quinteros M, Adelugba I, Morgada MN, Castelblanco AR, Davis EJ, Lanzirotti A, Hainer SJ, Vila AJ, Navea JG, Padilla-Benavides T. Front Mol Biosci. 2022 Nov 9;9:1037941. doi: 10.3389/fmolb.2022.1037941. eCollection 2022. PubMed |
| Distinct changes in endosomal composition promote NLRP3 inflammasome activation. Zhang Z, Venditti R, Ran L, Liu Z, Vivot K, Schurmann A, Bonifacino JS, De Matteis MA, Ricci R. Nat Immunol. 2023 Jan;24(1):30-41. doi: 10.1038/s41590-022-01355-3. Epub 2022 Nov 28. PubMed |
Selection-free endogenous tagging of cell lines by bicistronic co-expression of the surface antigen NGFR.
Seibert M, Kurrle N, Stolp V, Nurnberger H, Tzschentke S, Borner L, Wempe F, Serve H, Schnutgen F.
MethodsX. 2022 Nov 18;9:101929. doi: 10.1016/j.mex.2022.101929. eCollection 2022.
PubMed
Associated Plasmids |
| Loss of Gap Junction Factor Connexin 43 Results in an Increase of Exosomal Tetraspanins in Human Lung Cancer Cell Line A549. Fleck AP, Flotte AB, Si EP, Mu D. MicroPubl Biol. 2022 Nov 13;2022:10.17912/micropub.biology.000683. doi: 10.17912/micropub.biology.000683. eCollection 2022. PubMed |
An ER phospholipid hydrolase drives ER-associated mitochondrial constriction for fission and fusion.
Nguyen TT, Voeltz GK.
Elife. 2022 Nov 30;11:e84279. doi: 10.7554/eLife.84279.
PubMed
Associated Plasmids |
| Bridged Proteolysis Targeting Chimera (PROTAC) Enables Degradation of Undruggable Targets. Xiong Y, Zhong Y, Yim H, Yang X, Park KS, Xie L, Poulikakos PI, Han X, Xiong Y, Chen X, Liu J, Jin J. J Am Chem Soc. 2022 Dec 14;144(49):22622-22632. doi: 10.1021/jacs.2c09255. Epub 2022 Nov 30. PubMed |
| BRAF(V600E) in colorectal cancer reduces sensitivity to oxidative stress and promotes site-specific metastasis by stimulating glutathione synthesis. Laoukili J, van Schelven S, Kucukkose E, Verheem A, Goey K, Koopman M, Borel Rinkes I, Kranenburg O. Cell Rep. 2022 Nov 29;41(9):111728. doi: 10.1016/j.celrep.2022.111728. PubMed |
| Systematic generation and imaging of tandem repeats reveal base-pairing properties that promote RNA aggregation. Isiktas AU, Eshov A, Yang S, Guo JU. Cell Rep Methods. 2022 Nov 9;2(11):100334. doi: 10.1016/j.crmeth.2022.100334. eCollection 2022 Nov 21. PubMed |
| The PNUTS-PP1 complex acts as an intrinsic barrier to herpesvirus KSHV gene expression and replication. Devlin AM, Shukla A, Ruiz JC, Barnes SD, Govindan A, Hunter OV, Scarborough AM, D'Orso I, Conrad NK. Nat Commun. 2022 Dec 2;13(1):7447. doi: 10.1038/s41467-022-35268-4. PubMed |
| Autophagy inhibition signals through senescence to promote tumor suppression. Peng N, Kang HH, Feng Y, Minikes AM, Jiang X. Autophagy. 2022 Dec 15:1-17. doi: 10.1080/15548627.2022.2155794. PubMed |
| Arginine methylation of BRD4 by PRMT2/4 governs transcription and DNA repair. Liu L, Lin B, Yin S, Ball LE, Delaney JR, Long DT, Gan W. Sci Adv. 2022 Dec 9;8(49):eadd8928. doi: 10.1126/sciadv.add8928. Epub 2022 Dec 7. PubMed |
| USP32-regulated LAMTOR1 ubiquitination impacts mTORC1 activation and autophagy induction. Hertel A, Alves LM, Dutz H, Tascher G, Bonn F, Kaulich M, Dikic I, Eimer S, Steinberg F, Bremm A. Cell Rep. 2022 Dec 6;41(10):111653. doi: 10.1016/j.celrep.2022.111653. PubMed |
| Arginine-rich C9ORF72 ALS proteins stall ribosomes in a manner distinct from a canonical ribosome-associated quality control substrate. Kriachkov V, Ormsby AR, Kusnadi EP, McWilliam HEG, Mintern JD, Amarasinghe SL, Ritchie ME, Furic L, Hatters DM. J Biol Chem. 2023 Jan;299(1):102774. doi: 10.1016/j.jbc.2022.102774. Epub 2022 Dec 5. PubMed |
| HRS Regulates Small Extracellular Vesicle PD-L1 Secretion and Is Associated with Anti-PD-1 Treatment Efficacy. Xiao BL, Wang XL, Xia HF, Zhang LZ, Wang KM, Chen ZK, Zhong YH, Jiang HG, Zhou FX, Wang W, Chen GL, Chen G. Cancer Immunol Res. 2023 Feb 3;11(2):228-240. doi: 10.1158/2326-6066.CIR-22-0277. PubMed |
| Stress-induced reversible cell-cycle arrest requires PRC2/PRC1-mediated control of mitophagy in Drosophila germline stem cells and human iPSCs. Taslim TH, Hussein AM, Keshri R, Ishibashi JR, Chan TC, Nguyen BN, Liu S, Brewer D, Harper S, Lyons S, Garver B, Dang J, Balachandar N, Jhajharia S, Castillo DD, Mathieu J, Ruohola-Baker H. Stem Cell Reports. 2023 Jan 10;18(1):269-288. doi: 10.1016/j.stemcr.2022.11.004. Epub 2022 Dec 8. PubMed |
| Klf4 deficiency exacerbates myocardial ischemia/reperfusion injury in mice via enhancing ROCK1/DRP1 pathway-dependent mitochondrial fission. Li Y, Xiong Z, Jiang Y, Zhou H, Yi L, Hu Y, Zhai X, Liu J, Tian F, Chen Y. J Mol Cell Cardiol. 2023 Jan;174:115-132. doi: 10.1016/j.yjmcc.2022.11.009. Epub 2022 Dec 9. PubMed |
| Nonmuscle myosin IIA promotes the internalization of influenza A virus and regulates viral polymerase activity through interacting with nucleoprotein in human pulmonary cells. Chen J, Liu J, Chen Z, Feng D, Zhu C, Fan J, Zhang S, Zhang X, Xu J. Virol Sin. 2023 Feb;38(1):128-141. doi: 10.1016/j.virs.2022.12.002. Epub 2022 Dec 10. PubMed |
| Idarubicin combats abiraterone and enzalutamide resistance in prostate cells via targeting XPA protein. Zhang Y, Wei W, Li C, Yan S, Wang S, Xiao S, He C, Li J, Qi Z, Li B, Yang K, Li C. Cell Death Dis. 2022 Dec 12;13(12):1034. doi: 10.1038/s41419-022-05490-5. PubMed |
Macrophage NFATC2 mediates angiogenic signaling during mycobacterial infection.
Brewer WJ, Xet-Mull AM, Yu A, Sweeney MI, Walton EM, Tobin DM.
Cell Rep. 2022 Dec 13;41(11):111817. doi: 10.1016/j.celrep.2022.111817.
PubMed
Associated Plasmids |
| The histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA binding winged helix domain. Weber LM, Jia Y, Stielow B, Gisselbrecht SS, Cao Y, Ren Y, Rohner I, King J, Rothman E, Fischer S, Simon C, Forne I, Nist A, Stiewe T, Bulyk ML, Wang Z, Liefke R. Nucleic Acids Res. 2023 Jan 25;51(2):574-594. doi: 10.1093/nar/gkac1188. PubMed |
| The Golgi-resident protein ACBD3 concentrates STING at ER-Golgi contact sites to drive export from the ER. Motani K, Saito-Tarashima N, Nishino K, Yamauchi S, Minakawa N, Kosako H. Cell Rep. 2022 Dec 20;41(12):111868. doi: 10.1016/j.celrep.2022.111868. PubMed |
| A genome-wide CRISPR screen identifies CALCOCO2 as a regulator of beta cell function influencing type 2 diabetes risk. Rottner AK, Ye Y, Navarro-Guerrero E, Rajesh V, Pollner A, Bevacqua RJ, Yang J, Spigelman AF, Baronio R, Bautista A, Thomsen SK, Lyon J, Nawaz S, Smith N, Wesolowska-Andersen A, Fox JEM, Sun H, Kim SK, Ebner D, MacDonald PE, Gloyn AL. Nat Genet. 2023 Jan;55(1):54-65. doi: 10.1038/s41588-022-01261-2. Epub 2022 Dec 21. PubMed |
| CDK8 and CDK19 act redundantly to control the CFTR pathway in the intestinal epithelium. Prieto S, Dubra G, Camasses A, Aznar AB, Begon-Pescia C, Simboeck E, Pirot N, Gerbe F, Angevin L, Jay P, Krasinska L, Fisher D. EMBO Rep. 2023 Feb 6;24(2):e54261. doi: 10.15252/embr.202154261. Epub 2022 Dec 22. PubMed |
| Immune checkpoint therapy-elicited sialylation of IgG antibodies impairs antitumorigenic type I interferon responses in hepatocellular carcinoma. Wu RQ, Lao XM, Chen DP, Qin H, Mu M, Cao WJ, Deng J, Wan CC, Zhan WY, Wang JC, Xu L, Chen MS, Gao Q, Zheng L, Wei Y, Kuang DM. Immunity. 2023 Jan 10;56(1):180-192.e11. doi: 10.1016/j.immuni.2022.11.014. Epub 2022 Dec 22. PubMed |
| Genetic and pharmacological modulation of DNA mismatch repair heterogeneous tumors promotes immune surveillance. Amodio V, Lamba S, Chila R, Cattaneo CM, Mussolin B, Corti G, Rospo G, Berrino E, Tripodo C, Pisati F, Bartolini A, Aquilano MC, Marsoni S, Mauri G, Marchio C, Abrignani S, Di Nicolantonio F, Germano G, Bardelli A. Cancer Cell. 2023 Jan 9;41(1):196-209.e5. doi: 10.1016/j.ccell.2022.12.003. Epub 2022 Dec 29. PubMed |
| Network-based assessment of HDAC6 activity predicts preclinical and clinical responses to the HDAC6 inhibitor ricolinostat in breast cancer. Zeleke TZ, Pan Q, Chiuzan C, Onishi M, Li Y, Tan H, Alvarez MJ, Honan E, Yang M, Chia PL, Mukhopadhyay P, Kelly S, Wu R, Fenn K, Trivedi MS, Accordino M, Crew KD, Hershman DL, Maurer M, Jones S, High A, Peng J, Califano A, Kalinsky K, Yu J, Silva J. Nat Cancer. 2023 Feb;4(2):257-275. doi: 10.1038/s43018-022-00489-5. Epub 2022 Dec 30. PubMed |
| beta-Catenin activity induces an RNA biosynthesis program promoting therapy resistance in T-cell acute lymphoblastic leukemia. Garcia-Hernandez V, Arambilet D, Guillen Y, Lobo-Jarne T, Maqueda M, Gekas C, Gonzalez J, Iglesias A, Vega-Garcia N, Sentis I, Trincado JL, Marquez-Lopez I, Heyn H, Camos M, Espinosa L, Bigas A. EMBO Mol Med. 2023 Feb 8;15(2):e16554. doi: 10.15252/emmm.202216554. Epub 2023 Jan 4. PubMed |
| MLL3 loss drives metastasis by promoting a hybrid epithelial-mesenchymal transition state. Cui J, Zhang C, Lee JE, Bartholdy BA, Yang D, Liu Y, Erler P, Galbo PM Jr, Hodge DQ, Huangfu D, Zheng D, Ge K, Guo W. Nat Cell Biol. 2023 Jan;25(1):145-158. doi: 10.1038/s41556-022-01045-0. Epub 2023 Jan 5. PubMed |
| Helicobacter pylori-induced NAT10 stabilizes MDM2 mRNA via RNA acetylation to facilitate gastric cancer progression. Deng M, Zhang L, Zheng W, Chen J, Du N, Li M, Chen W, Huang Y, Zeng N, Song Y, Chen Y. J Exp Clin Cancer Res. 2023 Jan 6;42(1):9. doi: 10.1186/s13046-022-02586-w. PubMed |
| Temporally and spatially regulated collagen XVIII isoforms are involved in ureteric tree development via the TSP1-like domain. Rinta-Jaskari MM, Naillat F, Ruotsalainen HJ, Koivunen JT, Sasaki T, Pietila I, Elamaa HP, Kaur I, Manninen A, Vainio SJ, Pihlajaniemi TA. Matrix Biol. 2023 Jan;115:139-159. doi: 10.1016/j.matbio.2023.01.001. Epub 2023 Jan 6. PubMed |
| The HAPSTR2 retrogene buffers stress signaling and resilience in mammals. Amici DR, Cingoz H, Alasady MJ, Alhayek S, Phoumyvong CM, Sahni N, Yi SS, Mendillo ML. Nat Commun. 2023 Jan 11;14(1):152. doi: 10.1038/s41467-022-35697-1. PubMed |
| Loss of RREB1 in pancreatic beta cells reduces cellular insulin content and affects endocrine cell gene expression. Mattis KK, Krentz NAJ, Metzendorf C, Abaitua F, Spigelman AF, Sun H, Ikle JM, Thaman S, Rottner AK, Bautista A, Mazzaferro E, Perez-Alcantara M, Manning Fox JE, Torres JM, Wesolowska-Andersen A, Yu GZ, Mahajan A, Larsson A, MacDonald PE, Davies B, den Hoed M, Gloyn AL. Diabetologia. 2023 Apr;66(4):674-694. doi: 10.1007/s00125-022-05856-6. Epub 2023 Jan 12. PubMed |
| DIAPH3 condensates formed by liquid-liquid phase separation act as a regulatory hub for stress-induced actin cytoskeleton remodeling. Zhang K, Huang M, Li A, Wen J, Yan L, Li Y, Guo L, Senthil KS, Zhou Y, Chen G, Liu Y, Zhang X, Yao X, Qin D, Su H. Cell Rep. 2023 Jan 31;42(1):111986. doi: 10.1016/j.celrep.2022.111986. Epub 2023 Jan 10. PubMed |
| Expansion of interferon inducible gene pool via USP18 inhibition promotes cancer cell pyroptosis. Arimoto KI, Miyauchi S, Troutman TD, Zhang Y, Liu M, Stoner SA, Davis AG, Fan JB, Huang YJ, Yan M, Glass CK, Zhang DE. Nat Commun. 2023 Jan 17;14(1):251. doi: 10.1038/s41467-022-35348-5. PubMed |
| CIC reduces xCT/SLC7A11 expression and glutamate release in glioma. Park JW, Kilic O, Deo M, Jimenez-Cowell K, Demirdizen E, Kim H, Turcan S. Acta Neuropathol Commun. 2023 Jan 16;11(1):13. doi: 10.1186/s40478-023-01507-y. PubMed |
| CRISPR-screen identifies ZIP9 and dysregulated Zn2+ homeostasis as a cause of cancer-associated changes in glycosylation. Romer TB, Khoder-Agha F, Aasted MKM, de Haan N, Horn S, Dylander A, Zhang T, Pallesen EMH, Dabelsteen S, Wuhrer M, Hogsbro CF, Thomsen EA, Mikkelsen JG, Wandall HH. Glycobiology. 2023 Jan 16:cwad003. doi: 10.1093/glycob/cwad003. PubMed |
| A RIPK3-independent role of MLKL in suppressing parthanatos promotes immune evasion in hepatocellular carcinoma. Jiang X, Deng W, Tao S, Tang Z, Chen Y, Tian M, Wang T, Tao C, Li Y, Fang Y, Pu C, Gao J, Wang X, Qu W, Gai X, Ding Z, Fu Y, Zheng Y, Cao S, Zhou J, Huang M, Liu W, Xu J, Fan J, Shi Y. Cell Discov. 2023 Jan 17;9(1):7. doi: 10.1038/s41421-022-00504-0. PubMed |
| Smarcd3 is an epigenetic modulator of the metabolic landscape in pancreatic ductal adenocarcinoma. Ferguson LP, Gatchalian J, McDermott ML, Nakamura M, Chambers K, Rajbhandari N, Lytle NK, Rosenthal SB, Hamilton M, Albini S, Wartenberg M, Zlobec I, Galvan JA, Karamitopoulou E, Vavinskaya V, Wascher A, Lowy AM, Schurch CM, Puri PL, Bruneau BG, Hargreaves DC, Reya T. Nat Commun. 2023 Jan 18;14(1):292. doi: 10.1038/s41467-023-35796-7. PubMed |
| The ETS transcription factor ETV6 constrains the transcriptional activity of EWS-FLI to promote Ewing sarcoma. Lu DY, Ellegast JM, Ross KN, Malone CF, Lin S, Mabe NW, Dharia NV, Meyer A, Conway A, Su AH, Selich-Anderson J, Taslim C, Byrum AK, Seong BKA, Adane B, Gray NS, Rivera MN, Lessnick SL, Stegmaier K. Nat Cell Biol. 2023 Feb;25(2):285-297. doi: 10.1038/s41556-022-01059-8. Epub 2023 Jan 19. PubMed |
| A CRISPR screen in intestinal epithelial cells identifies novel factors for polarity and apical transport. Klee KMC, Hess MW, Lohmuller M, Herzog S, Pfaller K, Muller T, Vogel GF, Huber LA. Elife. 2023 Jan 20;12:e80135. doi: 10.7554/eLife.80135. PubMed |
| Cullin-5 deficiency orchestrates the tumor microenvironment to promote mammary tumor development through CREB1-CCL2 signaling. Chen S, Shao F, Zeng J, Guo S, Wang L, Sun H, Lei JH, Lyu X, Gao S, Chen Q, Miao K, Xu X, Deng CX. Sci Adv. 2023 Jan 20;9(3):eabq1395. doi: 10.1126/sciadv.abq1395. Epub 2023 Jan 20. PubMed |
| Disruption to the FOXO-PRDM1 axis resulting from deletions of chromosome 6 in acute lymphoblastic leukaemia. Sinclair PB, Cranston RE, Raninga P, Cheng J, Hanna R, Hawking Z, Hair S, Ryan SL, Enshaei A, Nakjang S, Rand V, Blair HJ, Moorman AV, Heidenreich O, Harrison CJ. Leukemia. 2023 Mar;37(3):636-649. doi: 10.1038/s41375-023-01816-0. Epub 2023 Jan 20. PubMed |
| Partial Truncation of the C-Terminal Domain of PTCH1 in Cancer Enhances Autophagy and Metabolic Adaptability. Caballero-Ruiz B, Gkotsi DS, Ollerton H, Morales-Alcala CC, Bordone R, Jenkins GML, Di Magno L, Canettieri G, Riobo-Del Galdo NA. Cancers (Basel). 2023 Jan 6;15(2):369. doi: 10.3390/cancers15020369. PubMed |
| ADAR RNA editing on antisense RNAs results in apparent U-to-C base changes on overlapping sense transcripts. Pecori R, Chillon I, Lo Giudice C, Arnold A, Wust S, Binder M, Marcia M, Picardi E, Papavasiliou FN. Front Cell Dev Biol. 2023 Jan 6;10:1080626. doi: 10.3389/fcell.2022.1080626. eCollection 2022. PubMed |
| RSK1 and RSK2 serine/threonine kinases regulate different transcription programs in cancer. Yang WS, Caliva MJ, Khadka VS, Tiirikainen M, Matter ML, Deng Y, Ramos JW. Front Cell Dev Biol. 2023 Jan 4;10:1015665. doi: 10.3389/fcell.2022.1015665. eCollection 2022. PubMed |
| PCIF1-mediated deposition of 5'-cap N(6),2'-O-dimethyladenosine in ACE2 and TMPRSS2 mRNA regulates susceptibility to SARS-CoV-2 infection. Wang L, Wang S, Wu L, Li W, Bray W, Clark AE, Gonzalez GM, Wang Y, Carlin AF, Rana TM. Proc Natl Acad Sci U S A. 2023 Jan 31;120(5):e2210361120. doi: 10.1073/pnas.2210361120. Epub 2023 Jan 23. PubMed |
| The mitochondrial inhibitor IF1 binds to the ATP synthase OSCP subunit and protects cancer cells from apoptosis. Galber C, Fabbian S, Gatto C, Grandi M, Carissimi S, Acosta MJ, Sgarbi G, Tiso N, Argenton F, Solaini G, Baracca A, Bellanda M, Giorgio V. Cell Death Dis. 2023 Jan 23;14(1):54. doi: 10.1038/s41419-023-05572-y. PubMed |
| A concerted mechanism involving ACAT and SREBPs by which oxysterols deplete accessible cholesterol to restrict microbial infection. Heisler DB, Johnson KA, Ma DH, Ohlson MB, Zhang L, Tran M, Corley CD, Abrams ME, McDonald JG, Schoggins JW, Alto NM, Radhakrishnan A. Elife. 2023 Jan 25;12:e83534. doi: 10.7554/eLife.83534. PubMed |
| CD28-CAR-T cell activation through FYN kinase signaling rather than LCK enhances therapeutic performance. Wu L, Brzostek J, Sakthi Vale PD, Wei Q, Koh CKT, Ong JXH, Wu LZ, Tan JC, Chua YL, Yap J, Song Y, Tan VJY, Tan TYY, Lai J, MacAry PA, Gascoigne NRJ. Cell Rep Med. 2023 Feb 21;4(2):100917. doi: 10.1016/j.xcrm.2023.100917. Epub 2023 Jan 24. PubMed |
| Diosgenin enhances liposome-enabled nucleic acid delivery and CRISPR/Cas9-mediated gene editing by modulating endocytic pathways. Lohchania B, Christopher AC, Arjunan P, Mahalingam G, Kathirvelu D, Prasannan A, Venkatesan V, Taneja P, Km MK, Thangavel S, Marepally S. Front Bioeng Biotechnol. 2023 Jan 9;10:1031049. doi: 10.3389/fbioe.2022.1031049. eCollection 2022. PubMed |
| Secreted PGK1 and IGFBP2 contribute to the bystander effect of miR-10b gene editing in glioma. Zhang Y, Rabinovsky R, Wei Z, El Fatimy R, Deforzh E, Luan B, Peshkin L, Uhlmann EJ, Krichevsky AM. Mol Ther Nucleic Acids. 2023 Jan 2;31:265-275. doi: 10.1016/j.omtn.2022.12.018. eCollection 2023 Mar 14. PubMed |
| The endothelial-enriched lncRNA LINC00607 mediates angiogenic function. Boos F, Oo JA, Warwick T, Gunther S, Izquierdo Ponce J, Lopez M, Rafii D, Buchmann G, Pham MD, Msheik ZS, Li T, Seredinski S, Haydar S, Kashefiolasl S, Plate KH, Behr R, Mietsch M, Krishnan J, Pullamsetti SS, Bibli SI, Hinkel R, Baker AH, Boon RA, Schulz MH, Wittig I, Miller FJ Jr, Brandes RP, Leisegang MS. Basic Res Cardiol. 2023 Jan 26;118(1):5. doi: 10.1007/s00395-023-00978-3. PubMed |
| Efficacy and safety of metabolic interventions for the treatment of severe COVID-19: in vitro, observational, and non-randomized open-label interventional study. Ehrlich A, Ioannidis K, Nasar M, Abu Alkian I, Daskal Y, Atari N, Kliker L, Rainy N, Hofree M, Shafran Tikva S, Houri I, Cicero A, Pavanello C, Sirtori CR, Cohen JB, Chirinos JA, Deutsch L, Cohen M, Gottlieb A, Bar-Chaim A, Shibolet O, Mandelboim M, Maayan SL, Nahmias Y. Elife. 2023 Jan 27;12:e79946. doi: 10.7554/eLife.79946. PubMed |
| A modular CRISPR screen identifies individual and combination pathways contributing to HIV-1 latency. Hsieh E, Janssens DH, Paddison PJ, Browne EP, Henikoff S, OhAinle M, Emerman M. PLoS Pathog. 2023 Jan 27;19(1):e1011101. doi: 10.1371/journal.ppat.1011101. eCollection 2023 Jan. PubMed |
| Identification and evaluation of midbrain specific longevity-related genes in exceptionally long-lived but healthy mice. Kim H, Huh YJ, Kim JH, Jo M, Shin JH, Park SC, Ahn JY, Lee YI, Lee Y. Front Aging Neurosci. 2023 Jan 11;14:1030807. doi: 10.3389/fnagi.2022.1030807. eCollection 2022. PubMed |
| MCB-613 exploits a collateral sensitivity in drug resistant EGFR -mutant non-small cell lung cancer through covalent inhibition of KEAP1. Bassil CF, Anderson GR, Mayro B, Askin KN, Winter PS, Gruber S, Hall TM, Hoj JP, Cerda-Smith C, Hutchinson HM, Killarney ST, Singleton KR, Qin L, Jubien-Girard K, Favreau C, Martin AR, Robert G, Benhida R, Auberger P, Pendergast AM, Lonard DM, Puissant A, Wood KC. bioRxiv. 2023 Jan 19:2023.01.17.524094. doi: 10.1101/2023.01.17.524094. Preprint. PubMed |
| LKB1-Dependent Regulation of TPI1 Creates a Divergent Metabolic Liability between Human and Mouse Lung Adenocarcinoma. Stein BD, Ferrarone JR, Gardner EE, Chang JW, Wu D, Hollstein PE, Liang RJ, Yuan M, Chen Q, Coukos JS, Sindelar M, Ngo B, Gross SS, Shaw RJ, Zhang C, Asara JM, Moellering RE, Varmus H, Cantley LC. Cancer Discov. 2023 Apr 3;13(4):1002-1025. doi: 10.1158/2159-8290.CD-22-0805. PubMed |
| FKBP12 is a major regulator of ALK2 activity in multiple myeloma cells. Quist-Lokken I, Andersson-Rusch C, Kastnes MH, Kolos JM, Jatzlau J, Hella H, Olsen OE, Sundan A, Knaus P, Hausch F, Holien T. Cell Commun Signal. 2023 Jan 30;21(1):25. doi: 10.1186/s12964-022-01033-9. PubMed |
| Microtubule nucleation from the fibrous corona by LIC1-pericentrin promotes chromosome congression. Wu J, Larreategui-Aparicio A, Lambers MLA, Bodor DL, Klaasen SJ, Tollenaar E, de Ruijter-Villani M, Kops GJPL. Curr Biol. 2023 Mar 13;33(5):912-925.e6. doi: 10.1016/j.cub.2023.01.010. Epub 2023 Jan 30. PubMed |
| NDUFA4L2 reduces mitochondrial respiration resulting in defective lysosomal trafficking in clear cell renal cell carcinoma. Kubala JM, Laursen KB, Schreiner R, Williams RM, van der Mijn JC, Crowley MJ, Mongan NP, Nanus DM, Heller DA, Gudas LJ. Cancer Biol Ther. 2023 Dec 31;24(1):2170669. doi: 10.1080/15384047.2023.2170669. PubMed |
| A genome-wide CRISPR functional survey of the human phagocytosis molecular machinery. Essletzbichler P, Sedlyarov V, Frommelt F, Soulat D, Heinz LX, Stefanovic A, Neumayer B, Superti-Furga G. Life Sci Alliance. 2023 Feb 1;6(4):e202201715. doi: 10.26508/lsa.202201715. Print 2023 Apr. PubMed |
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| Molecular characterization of human cytomegalovirus infection with single-cell transcriptomics. Schwartz M, Shnayder M, Nachshon A, Arazi T, Kitsberg Y, Levi Samia R, Lavi M, Kuint R, Tsabari R, Stern-Ginossar N. Nat Microbiol. 2023 Mar;8(3):455-468. doi: 10.1038/s41564-023-01325-x. Epub 2023 Feb 2. PubMed |
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| Effects of MITF on marker protein expression of multivesicular bodies and miRNA omics of extracellular vesicles of mice melanocyte cell line. Zhao L, Han H, Li Y, Pang Q. Acta Histochem. 2023 Feb;125(2):152011. doi: 10.1016/j.acthis.2023.152011. Epub 2023 Feb 2. PubMed |
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Associated Plasmids |
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| RTP4 silencing provokes tumor-intrinsic resistance to immune checkpoint blockade in colorectal cancer. Yamamoto Y, Shimada S, Akiyama Y, Tsukihara S, Sugimoto R, Kabashima A, Tokunaga M, Kinugasa Y, Kawakami Y, Tanaka S. J Gastroenterol. 2023 Jun;58(6):540-553. doi: 10.1007/s00535-023-01969-w. Epub 2023 Mar 2. PubMed |
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| Lysine 2-hydroxyisobutyrylation of NAT10 promotes cancer metastasis in an ac4C-dependent manner. Liao L, He Y, Li SJ, Yu XM, Liu ZC, Liang YY, Yang H, Yang J, Zhang GG, Deng CM, Wei X, Zhu YD, Xu TY, Zheng CC, Cheng C, Li A, Li ZG, Liu JB, Li B. Cell Res. 2023 May;33(5):355-371. doi: 10.1038/s41422-023-00793-4. Epub 2023 Mar 8. PubMed |
| TRIM28 promotes luminal cell plasticity in a mouse model of prostate cancer. Yende AS, Williams EC, Pletcher A, Helfand A, Ibeawuchi H, North TM, Latham PS, Horvath A, Shibata M. Oncogene. 2023 Apr;42(17):1347-1359. doi: 10.1038/s41388-023-02655-0. Epub 2023 Mar 8. PubMed |
| SIRT6 drives sensitivity to ferroptosis in anaplastic thyroid cancer through NCOA4-dependent autophagy. Yang Z, Huang R, Wang Y, Guan Q, Li D, Wu Y, Liao T, Wang Y, Xiang J. Am J Cancer Res. 2023 Feb 15;13(2):464-474. eCollection 2023. PubMed |
| PP6 regulation of Aurora A-TPX2 limits NDC80 phosphorylation and mitotic spindle size. Sobajima T, Kowalczyk KM, Skylakakis S, Hayward D, Fulcher LJ, Neary C, Batley C, Kurlekar S, Roberts E, Gruneberg U, Barr FA. J Cell Biol. 2023 May 1;222(5):e202205117. doi: 10.1083/jcb.202205117. Epub 2023 Mar 10. PubMed |
| USP15 Represses Hepatocellular Carcinoma Progression by Regulation of Pathways of Cell Proliferation and Cell Migration: A System Biology Analysis. Ren Y, Song Z, Rieser J, Ackermann J, Koch I, Lv X, Ji T, Cai X. Cancers (Basel). 2023 Feb 21;15(5):1371. doi: 10.3390/cancers15051371. PubMed |
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| Lymphatic Invasion of Plakoglobin-Dependent Tumor Cell Clusters Drives Formation of Polyclonal Lung Metastases in Colon Cancer. Kucukkose E, Laoukili J, Gorelick AN, Degner S, Lacle MM, van den Bent L, Peters NA, Verheem A, Hung WT, Frenkel NC, Wassenaar ECE, Lansu N, Lenos KJ, Vermeulen L, Koopman M, Roodhart JML, Kops GJPL, Borel Rinkes IHM, Hagendoorn J, Naxerova K, Kranenburg O. Gastroenterology. 2023 Aug;165(2):429-444.e15. doi: 10.1053/j.gastro.2023.02.047. Epub 2023 Mar 10. PubMed |
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| Single-cell transcriptomic atlas of mouse cochlear aging. Sun G, Zheng Y, Fu X, Zhang W, Ren J, Ma S, Sun S, He X, Wang Q, Ji Z, Cheng F, Yan K, Liu Z, Belmonte JCI, Qu J, Wang S, Chai R, Liu GH. Protein Cell. 2023 Apr 13;14(3):180-201. doi: 10.1093/procel/pwac058. PubMed |
| Acute liver steatosis translationally controls the epigenetic regulator MIER1 to promote liver regeneration in a study with male mice. Chen Y, Chen L, Wu X, Zhao Y, Wang Y, Jiang D, Liu X, Zhou T, Li S, Wei Y, Liu Y, Hu C, Zhou B, Qin J, Ying H, Ding Q. Nat Commun. 2023 Mar 18;14(1):1521. doi: 10.1038/s41467-023-37247-9. PubMed |
| DNMT3A low-expression is correlated to poor prognosis in childhood B-ALL and confers resistance to daunorubicin on leukemic cells. Li W, Liu S, Wang C, Cui L, Zhao X, Liu W, Zhang R, Li Z. BMC Cancer. 2023 Mar 18;23(1):255. doi: 10.1186/s12885-023-10724-6. PubMed |
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| Loss of PHF8 induces a viral mimicry response by activating endogenous retrotransposons. Liu Y, Hu L, Wu Z, Yuan K, Hong G, Lian Z, Feng J, Li N, Li D, Wong J, Chen J, Liu M, He J, Pang X. Nat Commun. 2023 Jul 15;14(1):4225. doi: 10.1038/s41467-023-39943-y. PubMed |
| A spatially defined human Notch receptor interaction network reveals Notch intracellular storage and Ataxin-2-mediated fast recycling. Bian W, Jiang H, Yao L, Hao W, Wu L, Li X. Cell Rep. 2023 Jul 25;42(7):112819. doi: 10.1016/j.celrep.2023.112819. Epub 2023 Jul 16. PubMed |
| The mitophagy receptor NIX induces vIRF-1 oligomerization and interaction with GABARAPL1 for the promotion of HHV-8 reactivation-induced mitophagy. Vo MT, Choi CY, Choi YB. PLoS Pathog. 2023 Jul 17;19(7):e1011548. doi: 10.1371/journal.ppat.1011548. eCollection 2023 Jul. PubMed |
| ING1 inhibits Twist1 expression to block EMT and is antagonized by the HDAC inhibitor vorinostat. Yang Y, Ma B, Djamshidi M, Zhang Q, Sarkar A, Chanda A, Tran U, Soh J, Sandall C, Chen HM, MacDonald JA, Bonni S, Sensen CW, Zheng J, Riabowol K. Eur J Cell Biol. 2023 Jul 13;102(3):151341. doi: 10.1016/j.ejcb.2023.151341. PubMed |
| Lysine butyrylation of HSP90 regulated by KAT8 and HDAC11 confers chemoresistance. He Y, Zheng CC, Yang J, Li SJ, Xu TY, Wei X, Chen WY, Jiang ZL, Xu JJ, Zhang GG, Cheng C, Chen KS, Shi XY, Qin DJ, Liu JB, Li B. Cell Discov. 2023 Jul 18;9(1):74. doi: 10.1038/s41421-023-00570-y. PubMed |
| APOBEC3 activity promotes the survival and evolution of drug-tolerant persister cells during acquired resistance to EGFR inhibitors in lung cancer. Garcia NMG, Becerra JN, McKinney BJ, DiMarco AV, Wu F, Fitzgibbon M, Alvarez JV. bioRxiv. 2023 Jul 3:2023.07.02.547443. doi: 10.1101/2023.07.02.547443. Preprint. PubMed |
| ARF6 plays a general role in targeting palmitoylated proteins from the Golgi to the plasma membrane. Wang J, Zheng LF, Ren S, Li DL, Chen C, Sun HH, Liu LY, Guo H, Zhao TJ. J Cell Sci. 2023 Aug 1;136(15):jcs261319. doi: 10.1242/jcs.261319. Epub 2023 Aug 9. PubMed |
| VGLL4 promotes vascular endothelium specification via TEAD1 in the vascular organoids and human pluripotent stem cells-derived endothelium model. Quan Y, Hu M, Jiang J, Jin P, Fan J, Li M, Fan X, Gong Y, Yang Y, Wang Y. Cell Mol Life Sci. 2023 Jul 19;80(8):215. doi: 10.1007/s00018-023-04858-w. PubMed |
| H3K27me3 of Rnf19a promotes neuroinflammatory response during Japanese encephalitis virus infection. Zhu S, Tao M, Li Y, Wang X, Zhao Z, Liu Y, Li Q, Li Q, Lu Y, Si Y, Cao S, Ye J. J Neuroinflammation. 2023 Jul 21;20(1):168. doi: 10.1186/s12974-023-02852-4. PubMed |
| Lipoylation is dependent on the ferredoxin FDX1 and dispensable under hypoxia in human cells. Joshi PR, Sadre S, Guo XA, McCoy JG, Mootha VK. J Biol Chem. 2023 Jul 20:105075. doi: 10.1016/j.jbc.2023.105075. PubMed |
| Loss of ANT1 Increases Fibrosis and Epithelial Cell Senescence in Idiopathic Pulmonary Fibrosis. Sui J, Boatz JC, Shi J, Hu Q, Li X, Zhang Y, Konigshoff M, Kliment CR. Am J Respir Cell Mol Biol. 2023 Jul 24. doi: 10.1165/rcmb.2022-0315OC. PubMed |
| microRNAs slow translating ribosomes to prevent protein misfolding in eukaryotes. Sako H, Youssef M, Elisseeva O, Akimoto T, Suzuki K, Ushida T, Yamamoto T. EMBO J. 2023 Jul 26:e112469. doi: 10.15252/embj.2022112469. PubMed |
| CBF-Beta Mitigates PI3K-Alpha-Specific Inhibitor Killing through PIM1 in PIK3CA-Mutant Gastric Cancer. Stanland LJ, Ang HX, Hoj JP, Chu Y, Tan P, Wood KC, Luftig MA. Mol Cancer Res. 2023 Nov 1;21(11):1148-1162. doi: 10.1158/1541-7786.MCR-23-0034. PubMed |
| Protein arginine methyltransferase 5 (PRMT5) is an actionable therapeutic target in CDK4/6 inhibitor-resistant ER+/RB-deficient breast cancer. Lin CC, Chang TC, Wang Y, Guo L, Gao Y, Bikorimana E, Lemoff A, Fang Y, Zhang H, Zhang Y, Ye D, Soria-Bretones I, Servetto A, Lee KM, Luo X, Otto J, Akamatsu H, Napolitano F, Mani R, Cescon D, Xu L, Xie Y, Mendell J, Hanker A, Arteaga C. Res Sq. 2023 Jul 10:rs.3.rs-2966905. doi: 10.21203/rs.3.rs-2966905/v1. Preprint. PubMed |
| Repression of ferroptotic cell death by mitochondrial calcium signaling. Wen H, Chen J, Zhao B, Wang S, Ma A, Dong H, Cheng X, Lin S, Li X, Herring L, Xin G, Ma Q, He K, Xie R, Lei Y, Ingold I, Cheng X, Li Z. Res Sq. 2023 Jul 10:rs.3.rs-3029860. doi: 10.21203/rs.3.rs-3029860/v1. Preprint. PubMed |
| De novo purine metabolism is a metabolic vulnerability of cancers with low p16 expression. Tangudu NK, Buj R, Wang J, Cole AR, Uboveja A, Fang R, Amalric A, Lyons MA, Chandran UR, Aird KM. bioRxiv. 2023 Jul 15:2023.07.15.549149. doi: 10.1101/2023.07.15.549149. Preprint. PubMed |
| Pooled endogenous protein tagging and recruitment for scalable discovery of effectors for induced proximity therapeutics. Serebrenik YV, Mani D, Maujean T, Burslem GM, Shalem O. bioRxiv. 2023 Jul 14:2023.07.13.548759. doi: 10.1101/2023.07.13.548759. Preprint. PubMed |
| Suppression of Ah Receptor (AhR) increases the aggressiveness of TNBC cells and 11-Cl-BBQ-activated AhR inhibits their growth. Elson DJ, Nguyen BD, Korjeff NA, Wilferd SF, Puig-Sanvicens V, Sang Jang H, Bernales S, Chakravarty S, Belmar S, Ureta G, Finlay D, Plaisier CL, Kolluri SK. Biochem Pharmacol. 2023 Jul 26:115706. doi: 10.1016/j.bcp.2023.115706. PubMed |
| SELENOF Controls Proliferation and Cell Death in Breast-Derived Immortalized and Cancer Cells. Ekyalongo RC, Flowers B, Sharma T, Zigrossi A, Zhang A, Quintanilla-Arteaga A, Singh K, Kastrati I. Cancers (Basel). 2023 Jul 19;15(14):3671. doi: 10.3390/cancers15143671. PubMed |
| CRISPR/Cas9 screen for genome-wide interrogation of essential MYC-bound E-boxes in cancer cells. Kazimierska M, Podralska M, Zurawek M, Wozniak T, Kasprzyk ME, Sura W, Losiewski W, Ziolkowska-Suchanek I, Kluiver J, van den Berg A, Rozwadowska N, Dzikiewicz-Krawczyk A. Mol Oncol. 2023 Nov;17(11):2295-2313. doi: 10.1002/1878-0261.13493. Epub 2023 Aug 7. PubMed |
Knockout of all ErbB-family genes delineates their roles in proliferation, survival, and migration.
Matsuda K, Hirayama D, Hino N, Kuno S, Sakaue-Sawano A, Miyawaki A, Matsuda M, Terai K.
J Cell Sci. 2023 Jul 31:jcs.261199. doi: 10.1242/jcs.261199.
PubMed
Associated Plasmids |
| Downregulation of VPS13C promotes cisplatin resistance in cervical cancer by upregulating GSTP1. Tan X, Wang X, Liao X, Wang X, Jiang Z, Liang W, Cao C, Gong D, Hu Z, Tian X. iScience. 2023 Jul 10;26(8):107315. doi: 10.1016/j.isci.2023.107315. eCollection 2023 Aug 18. PubMed |
| MAVS Antagonizes Human Stem Cell Senescence as a Mitochondrial Stabilizer. Wang C, Yang K, Liu X, Wang S, Song M, Belmonte JCI, Qu J, Liu GH, Zhang W. Research (Wash D C). 2023 Jul 27;6:0192. doi: 10.34133/research.0192. eCollection 2023. PubMed |
| Differential proteomics argues against a general role for CD9, CD81 or CD63 in the sorting of proteins into extracellular vesicles. Fan Y, Pionneau C, Cocozza F, Boelle PY, Chardonnet S, Charrin S, Thery C, Zimmermann P, Rubinstein E. J Extracell Vesicles. 2023 Aug;12(8):e12352. doi: 10.1002/jev2.12352. PubMed |
| Cardiac progenitor cell-derived extracellular vesicles promote angiogenesis through both associated- and co-isolated proteins. Roefs MT, Bauza-Martinez J, van de Wakker SI, Qin J, Olijve WT, Tuinte R, Rozeboom M, Snijders Blok C, Mol EA, Wu W, Vader P, Sluijter JPG. Commun Biol. 2023 Aug 1;6(1):800. doi: 10.1038/s42003-023-05165-7. PubMed |
| Extra centrosomes induce PIDD1-mediated inflammation and immunosurveillance. Garcia-Carpio I, Braun VZ, Weiler ES, Leone M, Ninerola S, Barco A, Fava LL, Villunger A. EMBO J. 2023 Aug 2:e113510. doi: 10.15252/embj.2023113510. PubMed |
| CD8(+) T cells maintain killing of MHC-I-negative tumor cells through the NKG2D-NKG2DL axis. Lerner EC, Woroniecka KI, D'Anniballe VM, Wilkinson DS, Mohan AA, Lorrey SJ, Waibl-Polania J, Wachsmuth LP, Miggelbrink AM, Jackson JD, Cui X, Raj JA, Tomaszewski WH, Cook SL, Sampson JH, Patel AP, Khasraw M, Gunn MD, Fecci PE. Nat Cancer. 2023 Sep;4(9):1258-1272. doi: 10.1038/s43018-023-00600-4. Epub 2023 Aug 3. PubMed |
| The Identification of CELSR3 and Other Potential Cell Surface Targets in Neuroendocrine Prostate Cancer. Van Emmenis L, Ku SY, Gayvert K, Branch JR, Brady NJ, Basu S, Russell M, Cyrta J, Vosoughi A, Sailer V, Alnajar H, Dardenne E, Koumis E, Puca L, Robinson BD, Feldkamp MD, Winkis A, Majewski N, Rupnow B, Gottardis MM, Elemento O, Rubin MA, Beltran H, Rickman DS. Cancer Res Commun. 2023 Aug 3;3(8):1447-1459. doi: 10.1158/2767-9764.CRC-22-0491. eCollection 2023 Aug. PubMed |
| Targeting BCL6 in Gastrointestinal Stromal Tumor Promotes p53-Mediated Apoptosis to Enhance the Antitumor Activity of Imatinib. Zeng X, Zhao F, Jia J, Ma X, Jiang Q, Zhang R, Li C, Wang T, Liu W, Hao Y, Tao K, Lou Z, Zhang P. Cancer Res. 2023 Nov 1;83(21):3624-3635. doi: 10.1158/0008-5472.CAN-23-0082. PubMed |
| MAGI1 Prevents Senescence and Promotes the DNA Damage Response in ER(+) Breast Cancer. Worthmuller J, Disler S, Pradervand S, Richard F, Haerri L, Ruiz Buendia GA, Fournier N, Desmedt C, Ruegg C. Cells. 2023 Jul 25;12(15):1929. doi: 10.3390/cells12151929. PubMed |
| A Size Filter Regulates Apical Protein Sorting. de Caestecker C, Macara IG. Res Sq [Preprint]. 2023 Aug 4:rs.3.rs-3210598. doi: 10.21203/rs.3.rs-3210598/v1. PubMed |
| DePARylation is critical for S phase progression and cell survival. Nie L, Wang C, Huang M, Liu X, Feng X, Tang M, Li S, Hang Q, Teng H, Shen X, Ma L, Gan B, Chen J. bioRxiv [Preprint]. 2024 Feb 2:2023.07.31.551317. doi: 10.1101/2023.07.31.551317. PubMed |
| KCTD1 is a new modulator of the KCASH family of Hedgehog suppressors. Di Fiore A, Bellardinelli S, Pirone L, Russo R, Angrisani A, Terriaca G, Bowen M, Bordin F, Besharat ZM, Canettieri G, Fabretti F, Di Gaetano S, Di Marcotullio L, Pedone E, Moretti M, De Smaele E. Neoplasia. 2023 Sep;43:100926. doi: 10.1016/j.neo.2023.100926. Epub 2023 Aug 17. PubMed |
| Mutational burden of XPNPEP3 leads to defects in mitochondrial complex I and cilia in NPHPL1. Tong L, Rao J, Yang C, Xu J, Lu Y, Zhang Y, Cang X, Xie S, Mao J, Jiang P. iScience. 2023 Jul 23;26(8):107446. doi: 10.1016/j.isci.2023.107446. eCollection 2023 Aug 18. PubMed |
| The non-classical major histocompatibility complex II protein SLA-DM is crucial for African swine fever virus replication. Pannhorst K, Carlson J, Holper JE, Grey F, Baillie JK, Hoper D, Wohnke E, Franzke K, Karger A, Fuchs W, Mettenleiter TC. Sci Rep. 2023 Aug 21;13(1):10342. doi: 10.1038/s41598-023-36788-9. PubMed |
| The actin binding protein profilin 1 is critical for mitochondria function. Read TA, Cisterna BA, Skruber K, Ahmadieh S, Lindamood HL, Vitriol JA, Shi Y, Lefebvre AEYT, Black JB, Butler MT, Bear JE, Cherezova A, Ilatovskaya DV, Weintraub NL, Vitriol EA. bioRxiv [Preprint]. 2023 Sep 19:2023.08.07.552354. doi: 10.1101/2023.08.07.552354. PubMed |
| Comprehensive isotopomer analysis of glutamate and aspartate in small tissue samples. Cai F, Bezwada D, Cai L, Mahar R, Wu Z, Chang MC, Pachnis P, Yang C, Kelekar S, Gu W, Brooks B, Ko B, Vu HS, Mathews TP, Zacharias LG, Martin-Sandoval M, Do D, Oaxaca KC, Jin ES, Margulis V, Malloy CR, Merritt ME, DeBerardinis RJ. Cell Metab. 2023 Oct 3;35(10):1830-1843.e5. doi: 10.1016/j.cmet.2023.07.013. Epub 2023 Aug 22. PubMed |
| The midnolin-proteasome pathway catches proteins for ubiquitination-independent degradation. Gu X, Nardone C, Kamitaki N, Mao A, Elledge SJ, Greenberg ME. Science. 2023 Aug 25;381(6660):eadh5021. doi: 10.1126/science.adh5021. Epub 2023 Aug 25. PubMed |
| MDM2 Influences ACE2 Stability and SARS-CoV-2 Uptake. Emslander Q, Krey K, Hamad S, Maidl S, Oubraham L, Hesse J, Henrici A, Austen K, Mergner J, Grass V, Pichlmair A. Viruses. 2023 Aug 18;15(8):1763. doi: 10.3390/v15081763. PubMed |
| Uncovering oligodendrocyte enhancers that control Cnp expression. Fan C, An H, Kim D, Park Y. Hum Mol Genet. 2023 Nov 17;32(23):3225-3236. doi: 10.1093/hmg/ddad141. PubMed |
| Cytoskeletal adaptation following long-term dysregulation of actomyosin in neuronal processes. Cisterna BA, Skruber K, Jane ML, Camesi CI, Nguyen ID, Warp PV, Black JB, Butler MT, Bear JE, Tracy-Ann R, Vitriol EA. bioRxiv [Preprint]. 2023 Sep 10:2023.08.25.554891. doi: 10.1101/2023.08.25.554891. PubMed |
| KLRC1 knockout overcomes HLA-E-mediated inhibition and improves NK cell antitumor activity against solid tumors. Mac Donald A, Guipouy D, Lemieux W, Harvey M, Bordeleau LJ, Guay D, Romero H, Li Y, Dion R, Beland K, Haddad E. Front Immunol. 2023 Aug 21;14:1231916. doi: 10.3389/fimmu.2023.1231916. eCollection 2023. PubMed |
Alternative splicing of its 5' UTR limits CD20 mRNA translation and enables resistance to CD20-directed immunotherapies.
Ang Z, Paruzzo L, Hayer KE, Schmidt C, Torres-Diz M, Xu F, Zankharia U, Zhang Y, Soldan SS, Zheng S, Falkenstein CD, Loftus JP, Yang SY, Asnani M, King Sainos P, Pillai V, Chong ER, Li M, Tasian SK, Barash Y, Lieberman PM, Ruella M, Schuster SJ, Thomas-Tikhonenko A.
Blood. 2023 Sep 8:blood.2023020400. doi: 10.1182/blood.2023020400.
PubMed
Associated Plasmids |
| Zika virus targets human trophoblast stem cells and prevents syncytialization in placental trophoblast organoids. Wu H, Huang XY, Sun MX, Wang Y, Zhou HY, Tian Y, He B, Li K, Li DY, Wu AP, Wang H, Qin CF. Nat Commun. 2023 Sep 8;14(1):5541. doi: 10.1038/s41467-023-41158-0. PubMed |
| Glucose-induced and ChREBP: MLX-mediated lipogenic program promotes hepatocellular carcinoma development. Yu A, Yu P, Zhu Y, Zhu R, Sun R, Ye D, Yu FX. Oncogene. 2023 Oct;42(43):3182-3193. doi: 10.1038/s41388-023-02831-2. Epub 2023 Sep 9. PubMed |
| PCR-Based Strategy for Introducing CRISPR/Cas9 Machinery into Hematopoietic Cell Lines. Gonzalez-Romero E, Martinez-Valiente C, Garcia-Garcia G, Rosal-Vela A, Millan JM, Sanz MA, Sanz G, Liquori A, Cervera JV, Vazquez-Manrique RP. Cancers (Basel). 2023 Aug 25;15(17):4263. doi: 10.3390/cancers15174263. PubMed |
| RNF8 ubiquitylation of XRN2 facilitates R-loop resolution and restrains genomic instability in BRCA1 mutant cells. Krishnan R, Lapierre M, Gautreau B, Nixon KCJ, El Ghamrasni S, Patel PS, Hao J, Yerlici VT, Guturi KKN, St-Germain J, Mateo F, Saad A, Algouneh A, Earnshaw R, Shili D, Seitova A, Miller J, Khosraviani N, Penn A, Ho B, Sanchez O, Hande MP, Masson JY, Brown GW, Alaoui-Jamali M, Reynolds JJ, Arrowsmith C, Raught B, Pujana MA, Mekhail K, Stewart GS, Hakem A, Hakem R. Nucleic Acids Res. 2023 Oct 27;51(19):10484-10505. doi: 10.1093/nar/gkad733. PubMed |
| Y-27632 acts beyond ROCK inhibition to maintain epidermal stem-like cells in culture. Witkowski TA, Li B, Andersen JG, Kumar B, Mroz EA, Rocco JW. J Cell Sci. 2023 Sep 1;136(17):jcs260990. doi: 10.1242/jcs.260990. Epub 2023 Sep 12. PubMed |
| Clinical Correlates of Venetoclax-Based Combination Sensitivities to Augment Acute Myeloid Leukemia Therapy. Eide CA, Kurtz SE, Kaempf A, Long N, Joshi SK, Nechiporuk T, Huang A, Dibb CA, Taylor A, Bottomly D, McWeeney SK, Minnier J, Lachowiez CA, Saultz JN, Swords RT, Agarwal A, Chang BH, Druker BJ, Tyner JW. Blood Cancer Discov. 2023 Nov 1;4(6):452-467. doi: 10.1158/2643-3230.BCD-23-0014. PubMed |
| Temporal analyses reveal a pivotal role for sense and antisense enhancer RNAs in coordinate immunoglobulin lambda locus activation. Gao Z, Smith AL, Scott JNF, Bevington SL, Boyes J. Nucleic Acids Res. 2023 Oct 27;51(19):10344-10363. doi: 10.1093/nar/gkad741. PubMed |
| The FAM104 proteins VCF1/2 promote the nuclear localization of p97/VCP. Korner M, Meyer SR, Marincola G, Kern MJ, Grimm C, Schuelein-Voelk C, Fischer U, Hofmann K, Buchberger A. Elife. 2023 Sep 15;12:e92409. doi: 10.7554/eLife.92409. PubMed |
| Disease-related PSS1 mutant impedes the formation and function of osteoclasts. Sugahara S, Ishino Y, Sawada K, Iwata T, Shimanaka Y, Aoki J, Arai H, Kono N. J Lipid Res. 2023 Nov;64(11):100443. doi: 10.1016/j.jlr.2023.100443. Epub 2023 Sep 14. PubMed |
| Metabolic Reprogramming via ACOD1 depletion enhances function of human induced pluripotent stem cell-derived CAR-macrophages in solid tumors. Wang X, Su S, Zhu Y, Cheng X, Cheng C, Chen L, Lei A, Zhang L, Xu Y, Ye D, Zhang Y, Li W, Zhang J. Nat Commun. 2023 Sep 18;14(1):5778. doi: 10.1038/s41467-023-41470-9. PubMed |
| Generation of mouse models carrying B cell restricted single or multiplexed loss-of-function mutations through CRISPR-Cas9 gene editing. Ten Hacken E, Gruber M, Hernandez-Sanchez M, Hoffmann GB, Baranowski K, Redd RA, Clement K, Livak K, Wu CJ. STAR Protoc. 2023 Dec 15;4(4):102165. doi: 10.1016/j.xpro.2023.102165. Epub 2023 Sep 18. PubMed |
| The NCOR-HDAC3 co-repressive complex modulates the leukemogenic potential of the transcription factor ERG. Kugler E, Madiwale S, Yong D, Thoms JAI, Birger Y, Sykes DB, Schmoellerl J, Drakul A, Priebe V, Yassin M, Aqaqe N, Rein A, Fishman H, Geron I, Chen CW, Raught B, Liu Q, Ogana H, Liedke E, Bourquin JP, Zuber J, Milyavsky M, Pimanda J, Prive GG, Izraeli S. Nat Commun. 2023 Sep 21;14(1):5871. doi: 10.1038/s41467-023-41067-2. PubMed |
| Tau suppresses microtubule-regulated pancreatic insulin secretion. Mangiafico SP, Tuo QZ, Li XL, Liu Y, Haralambous C, Ding XL, Ayton S, Wang Q, Laybutt DR, Chan JY, Zhang X, Kos C, Thomas HE, Loudovaris T, Yang CH, Joannides CN, Lamont BJ, Dai L, He HH, Dong B, Andrikopoulos S, Bush AI, Lei P. Mol Psychiatry. 2023 Sep;28(9):3982-3993. doi: 10.1038/s41380-023-02267-w. Epub 2023 Sep 21. PubMed |
| Defining E3 ligase-substrate relationships through multiplex CRISPR screening. Timms RT, Mena EL, Leng Y, Li MZ, Tchasovnikarova IA, Koren I, Elledge SJ. Nat Cell Biol. 2023 Oct;25(10):1535-1545. doi: 10.1038/s41556-023-01229-2. Epub 2023 Sep 21. PubMed |
| ATG14 plays a critical role in hepatic lipid droplet homeostasis. Huang M, Zhang Y, Park J, Chowdhury K, Xu J, Lu A, Wang L, Zhang W, Ekser B, Yu L, Dong XC. Metabolism. 2023 Nov;148:155693. doi: 10.1016/j.metabol.2023.155693. Epub 2023 Sep 22. PubMed |
| A conserved HOTAIRM1-HOXA1 regulatory axis contributes early to neuronal differentiation. Segal D, Coulombe S, Sim J, Dostie J. RNA Biol. 2023 Jan;20(1):1523-1539. doi: 10.1080/15476286.2023.2258028. Epub 2023 Sep 24. PubMed |
| CRISPR/Cas9-Mediated CtBP1 Gene Editing Enhances Chemosensitivity and Inhibits Metastatic Potential in Esophageal Squamous Cell Carcinoma Cells. Akhtar J, Imran M, Wang G. Int J Mol Sci. 2023 Sep 13;24(18):14030. doi: 10.3390/ijms241814030. PubMed |
| Oncogenic KRAS Drives Lipofibrogenesis to Promote Angiogenesis and Colon Cancer Progression. Hsu WH, LaBella KA, Lin Y, Xu P, Lee R, Hsieh CE, Yang L, Zhou A, Blecher JM, Wu CJ, Lin K, Shang X, Jiang S, Spring DJ, Xia Y, Chen P, Shen JP, Kopetz S, DePinho RA. Cancer Discov. 2023 Dec 12;13(12):2652-2673. doi: 10.1158/2159-8290.CD-22-1467. PubMed |
Assigning functionality to cysteines by base editing of cancer dependency genes.
Li H, Ma T, Remsberg JR, Won SJ, DeMeester KE, Njomen E, Ogasawara D, Zhao KT, Huang TP, Lu B, Simon GM, Melillo B, Schreiber SL, Lykke-Andersen J, Liu DR, Cravatt BF.
Nat Chem Biol. 2023 Nov;19(11):1320-1330. doi: 10.1038/s41589-023-01428-w. Epub 2023 Oct 2.
PubMed
Associated Plasmids |
| Distinct and targetable role of calcium-sensing receptor in leukaemia. Pereira RS, Kumar R, Cais A, Paulini L, Kahler A, Bravo J, Minciacchi VR, Krack T, Kowarz E, Zanetti C, Godavarthy PS, Hoeller F, Llavona P, Stark T, Tascher G, Nowak D, Meduri E, Huntly BJP, Munch C, Pampaloni F, Marschalek R, Krause DS. Nat Commun. 2023 Oct 6;14(1):6242. doi: 10.1038/s41467-023-41770-0. PubMed |
| Upregulation of exosome secretion from tumor-associated macrophages plays a key role in the suppression of anti-tumor immunity. Zhong W, Lu Y, Han X, Yang J, Qin Z, Zhang W, Yu Z, Wu B, Liu S, Xu W, Zheng C, Schuchter LM, Karakousis GC, Mitchell TC, Amaravadi R, Flowers AJ, Gimotty PA, Xiao M, Mills G, Herlyn M, Dong H, Mitchell MJ, Kim J, Xu X, Guo W. Cell Rep. 2023 Oct 31;42(10):113224. doi: 10.1016/j.celrep.2023.113224. Epub 2023 Oct 8. PubMed |
| The RNA methyltransferase METTL16 enhances cholangiocarcinoma growth through PRDM15-mediated FGFR4 expression. Liu N, Zhang J, Chen W, Ma W, Wu T. J Exp Clin Cancer Res. 2023 Oct 11;42(1):263. doi: 10.1186/s13046-023-02844-5. PubMed |
| Apoptotic stress causes mtDNA release during senescence and drives the SASP. Victorelli S, Salmonowicz H, Chapman J, Martini H, Vizioli MG, Riley JS, Cloix C, Hall-Younger E, Machado Espindola-Netto J, Jurk D, Lagnado AB, Sales Gomez L, Farr JN, Saul D, Reed R, Kelly G, Eppard M, Greaves LC, Dou Z, Pirius N, Szczepanowska K, Porritt RA, Huang H, Huang TY, Mann DA, Masuda CA, Khosla S, Dai H, Kaufmann SH, Zacharioudakis E, Gavathiotis E, LeBrasseur NK, Lei X, Sainz AG, Korolchuk VI, Adams PD, Shadel GS, Tait SWG, Passos JF. Nature. 2023 Oct;622(7983):627-636. doi: 10.1038/s41586-023-06621-4. Epub 2023 Oct 11. PubMed |
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| Avian influenza A viruses exhibit plasticity in sialylglycoconjugate receptor usage in human lung cells. Liang C-Y, Huang I, Han J, Sownthirarajan B, Kulhankova K, Murray NB, Taherzadeh M, Archer-Hartmann S, Pepi L, Manivasagam S, Plung J, Sturtz M, Yu Y, Vogel OA, Kandasamy M, Gourronc FA, Klingelhutz AJ, Choudhury B, Rong L, Perez JT, Azadi P, McCray PB Jr, Neelamegham S, Manicassamy B. J Virol. 2023 Nov 30;97(11):e0090623. doi: 10.1128/jvi.00906-23. Epub 2023 Oct 16. PubMed |
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| EBV abortive lytic cycle promotes nasopharyngeal carcinoma progression through recruiting monocytes and regulating their directed differentiation. Xu X, Zhu N, Zheng J, Peng Y, Zeng MS, Deng K, Duan C, Yuan Y. PLoS Pathog. 2024 Jan 11;20(1):e1011934. doi: 10.1371/journal.ppat.1011934. eCollection 2024 Jan. PubMed |
| The heterogeneity of signaling pathways and drug responses in intrahepatic cholangiocarcinoma with distinct genetic mutations. Feng Y, Zhao M, Wang L, Li L, Lei JH, Zhou J, Chen J, Wu Y, Miao K, Deng CX. Cell Death Dis. 2024 Jan 11;15(1):34. doi: 10.1038/s41419-023-06406-7. PubMed |
| IFI35 limits antitumor immunity in triple-negative breast cancer via CCL2 secretion. Xu B, Sun H, Liu S, Liao L, Song X, Wu Y, Hou Y, Jin W. Oncogene. 2024 Mar;43(10):693-702. doi: 10.1038/s41388-023-02934-w. Epub 2024 Jan 12. PubMed |
| Mitochondrial stress activates YAP/TAZ through RhoA oxidation to promote liver injury. Kwon A, Lee NY, Yu JH, Choi MG, Park J, Koo JH. Cell Death Dis. 2024 Jan 15;15(1):51. doi: 10.1038/s41419-024-06448-5. PubMed |
| Tolerance to colibactin correlates with homologous recombination proficiency and resistance to irinotecan in colorectal cancer cells. Sogari A, Rovera E, Grasso G, Mariella E, Reilly NM, Lamba S, Mauri G, Durinikova E, Vitiello PP, Lorenzato A, Avolio M, Piumatti E, Bonoldi E, Aquilano MC, Arena S, Sartore-Bianchi A, Siena S, Trusolino L, Donalisio M, Russo M, Di Nicolantonio F, Lembo D, Bardelli A. Cell Rep Med. 2024 Feb 20;5(2):101376. doi: 10.1016/j.xcrm.2023.101376. Epub 2024 Jan 15. PubMed |
| USP5 facilitates bladder cancer progression by stabilizing the c-Jun protein. Zhang HH, Zhang AQ, Peng P, Huang L, Liu CY, Nie XR, Hou DF, Zhang X, Li SZ. Cancer Cell Int. 2024 Jan 16;24(1):32. doi: 10.1186/s12935-024-03222-7. PubMed |
| BMP-ACVR1 Axis is Critical for Efficacy of PRC2 Inhibitors in B-Cell Lymphoma. Liu D, Li Z, Tan D, An Y, Chu L, Chen T, Li W, Zhou A, Xiang R, Zhang L, Qu Y, Qi W. Adv Sci (Weinh). 2024 Mar;11(12):e2306499. doi: 10.1002/advs.202306499. Epub 2024 Jan 16. PubMed |
| VGLL1 cooperates with TEAD4 to control human trophectoderm lineage specification. Yang Y, Jia W, Luo Z, Li Y, Liu H, Fu L, Li J, Jiang Y, Lai J, Li H, Saeed BJ, Zou Y, Lv Y, Wu L, Zhou T, Shan Y, Liu C, Lai Y, Liu L, Hutchins AP, Esteban MA, Mazid MA, Li W. Nat Commun. 2024 Jan 17;15(1):583. doi: 10.1038/s41467-024-44780-8. PubMed |
| Alternative splicing of latrophilin-3 controls synapse formation. Wang S, DeLeon C, Sun W, Quake SR, Roth BL, Sudhof TC. Nature. 2024 Feb;626(7997):128-135. doi: 10.1038/s41586-023-06913-9. Epub 2024 Jan 17. PubMed |
| Bispecific BCMA/CD24 CAR-T cells control multiple myeloma growth. Sun F, Cheng Y, Wanchai V, Guo W, Mery D, Xu H, Gai D, Siegel E, Bailey C, Ashby C, Al Hadidi S, Schinke C, Thanendrarajan S, Ma Y, Yi Q, Orlowski RZ, Zangari M, van Rhee F, Janz S, Bishop G, Tricot G, Shaughnessy JD Jr, Zhan F. Nat Commun. 2024 Jan 19;15(1):615. doi: 10.1038/s41467-024-44873-4. PubMed |
| Non-canonical antigens are the largest fraction of peptides presented by MHC class I in mismatch repair deficient murine colorectal cancer. Rospo G, Chila R, Matafora V, Basso V, Lamba S, Bartolini A, Bachi A, Di Nicolantonio F, Mondino A, Germano G, Bardelli A. Genome Med. 2024 Jan 19;16(1):15. doi: 10.1186/s13073-023-01275-3. PubMed |
| The LKB1-TSSK1B axis controls YAP phosphorylation to regulate the Hippo-YAP pathway. Kim CL, Lim SB, Choi SH, Kim DH, Sim YE, Jo EH, Kim K, Lee K, Park HS, Lim SB, Kang LJ, Jeong HS, Lee Y, Hansen CG, Mo JS. Cell Death Dis. 2024 Jan 20;15(1):76. doi: 10.1038/s41419-024-06465-4. PubMed |
| LUBAC-mediated M1 Ub regulates necroptosis by segregating the cellular distribution of active MLKL. Weinelt N, Wachtershauser KN, Celik G, Jeiler B, Gollin I, Zein L, Smith S, Andrieux G, Das T, Roedig J, Feist L, Rotter B, Boerries M, Pampaloni F, van Wijk SJL. Cell Death Dis. 2024 Jan 20;15(1):77. doi: 10.1038/s41419-024-06447-6. PubMed |
| HPV16 E6 Oncogene Contributes to Cancer Immune Evasion by Regulating PD-L1 Expression through a miR-143/HIF-1a Pathway. Konstantopoulos G, Leventakou D, Saltiel DR, Zervoudi E, Logotheti E, Pettas S, Karagianni K, Daiou A, Hatzistergos KE, Dafou D, Arsenakis M, Psyrri A, Kottaridi C. Viruses. 2024 Jan 12;16(1):113. doi: 10.3390/v16010113. PubMed |
| SEL1L-HRD1 ER-associated degradation regulates leptin receptor maturation and signaling in POMC neurons in diet-induced obesity. Mao H, Kim GH, Qi L. Res Sq [Preprint]. 2024 Jan 12:rs.3.rs-3768472. doi: 10.21203/rs.3.rs-3768472/v1. PubMed |
| Loss of ZNRF3/RNF43 Unleashes EGFR in Cancer. Yue F, Ku AT, Stevens PD, Michalski MN, Jiang W, Tu J, Shi Z, Dou Y, Wang Y, Feng XH, Hostetter G, Wu X, Huang S, Shroyer NF, Zhang B, Williams BO, Liu Q, Lin X, Li Y. bioRxiv [Preprint]. 2024 Jan 11:2024.01.10.574969. doi: 10.1101/2024.01.10.574969. PubMed |
| EXO1 protects BRCA1-deficient cells against toxic DNA lesions. van de Kooij B, Schreuder A, Pavani R, Garzero V, Uruci S, Wendel TJ, van Hoeck A, San Martin Alonso M, Everts M, Koerse D, Callen E, Boom J, Mei H, Cuppen E, Luijsterburg MS, van Vugt MATM, Nussenzweig A, van Attikum H, Noordermeer SM. Mol Cell. 2024 Feb 15;84(4):659-674.e7. doi: 10.1016/j.molcel.2023.12.039. Epub 2024 Jan 23. PubMed |
| The efficacy of chemotherapy is limited by intratumoral senescent cells expressing PD-L2. Chaib S, Lopez-Dominguez JA, Lalinde-Gutierrez M, Prats N, Marin I, Boix O, Garcia-Garijo A, Meyer K, Munoz MI, Aguilera M, Mateo L, Stephan-Otto Attolini C, Llanos S, Perez-Ramos S, Escorihuela M, Al-Shahrour F, Cash TP, Tchkonia T, Kirkland JL, Abad M, Gros A, Arribas J, Serrano M. Nat Cancer. 2024 Jan 24. doi: 10.1038/s43018-023-00712-x. PubMed |
| TXNRD1 drives the innate immune response in senescent cells with implications for age-associated inflammation. Hao X, Zhao B, Towers M, Liao L, Monteiro EL, Xu X, Freeman C, Peng H, Tang HY, Havas A, Kossenkov AV, Berger SL, Adams PD, Speicher DW, Schultz D, Marmorstein R, Zaret KS, Zhang R. Nat Aging. 2024 Feb;4(2):185-197. doi: 10.1038/s43587-023-00564-1. Epub 2024 Jan 24. PubMed |
| PRRSV degrades MDA5 via dual autophagy receptors P62 and CCT2 to evade antiviral innate immunity. Sun R, Guo Y, Zhang L, Zhang H, Yin B, Li X, Li C, Yang L, Zhang L, Li Z, Huang J. Virol Sin. 2024 Apr;39(2):264-276. doi: 10.1016/j.virs.2024.01.005. Epub 2024 Jan 23. PubMed |
| High throughput functional profiling of genes at intraocular pressure loci reveals distinct networks for glaucoma. Greatbatch CJ, Lu Q, Hung S, Barnett AJ, Wing K, Liang H, Han X, Zhou T, Siggs OM, Mackey DA, Cook AL, Senabouth A, Liu GS, Craig JE, MacGregor S, Powell JE, Hewitt AW. Hum Mol Genet. 2024 Apr 18;33(9):739-751. doi: 10.1093/hmg/ddae003. PubMed |
| Interplay between ATRX and IDH1 mutations governs innate immune responses in diffuse gliomas. Hariharan S, Whitfield BT, Pirozzi CJ, Waitkus MS, Brown MC, Bowie ML, Irvin DM, Roso K, Fuller R, Hostettler J, Dharmaiah S, Gibson EA, Briley A, Mangoli A, Fraley C, Shobande M, Stevenson K, Zhang G, Malgulwar PB, Roberts H, Roskoski M, Spasojevic I, Keir ST, He Y, Castro MG, Huse JT, Ashley DM. Nat Commun. 2024 Jan 25;15(1):730. doi: 10.1038/s41467-024-44932-w. PubMed |
Calcium transients trigger switch-like discharge of prostaglandin E(2) in an extracellular signal-regulated kinase-dependent manner.
Watabe T, Yamahira S, Takakura K, Thumkeo D, Narumiya S, Matsuda M, Terai K.
eLife. 2024 Jan 26;12:RP86727. doi: 10.7554/eLife.86727.
PubMed
Associated Plasmids |
| Weakened APC/C activity at mitotic exit drives cancer vulnerability to KIF18A inhibition. Gliech CR, Yeow ZY, Tapias-Gomez D, Yang Y, Huang Z, Tijhuis AE, Spierings DC, Foijer F, Chung G, Tamayo N, Bahrami-Nejad Z, Collins P, Nguyen TT, Plata Stapper A, Hughes PE, Payton M, Holland AJ. EMBO J. 2024 Mar;43(5):666-694. doi: 10.1038/s44318-024-00031-6. Epub 2024 Jan 26. PubMed |
| Intracellular trafficking of HIV-1 Gag via Syntaxin 6-positive compartments/vesicles: Involvement in tumor necrosis factor secretion. Tsurutani N, Momose F, Ogawa K, Sano K, Morikawa Y. J Biol Chem. 2024 Mar;300(3):105687. doi: 10.1016/j.jbc.2024.105687. Epub 2024 Jan 26. PubMed |
| Reconstitution of human PDAC using primary cells reveals oncogenic transcriptomic features at tumor onset. Xu Y, Nipper MH, Dominguez AA, Ye Z, Akanuma N, Lopez K, Deng JJ, Arenas D, Sanchez A, Sharkey FE, Court CM, Singhi AD, Wang H, Fernandez-Zapico ME, Sun LZ, Zheng S, Chen Y, Liu J, Wang P. Nat Commun. 2024 Jan 27;15(1):818. doi: 10.1038/s41467-024-45097-2. PubMed |
| FLIP(C1orf112)-FIGNL1 complex regulates RAD51 chromatin association to promote viability after replication stress. Tischler JD, Tsuchida H, Bosire R, Oda TT, Park A, Adeyemi RO. Nat Commun. 2024 Jan 29;15(1):866. doi: 10.1038/s41467-024-45139-9. PubMed |
| Constitutive Plasma Membrane Turnover in T-REx293 cells via Ordered Membrane Domain Endocytosis under Mitochondrial Control. Deisl C, Moe OW, Hilgemann DW. bioRxiv [Preprint]. 2024 Feb 14:2024.01.17.576124. doi: 10.1101/2024.01.17.576124. PubMed |
| NRAS Mutant Dictates AHCYL1-Governed ER Calcium Homeostasis for Melanoma Tumor Growth. Cai C, Tu J, Najarro J, Zhang R, Fan H, Zhang FQ, Li J, Xie Z, Su R, Dong L, Arellano N, Ciboddo M, Elf SE, Gao X, Chen J, Wu R. Mol Cancer Res. 2024 Apr 2;22(4):386-401. doi: 10.1158/1541-7786.MCR-23-0445. PubMed |
| p53 promotes antiviral innate immunity by driving hexosamine metabolism. Xia W, Jiang P. Cell Rep. 2024 Feb 27;43(2):113724. doi: 10.1016/j.celrep.2024.113724. Epub 2024 Jan 30. PubMed |
| Activation of recombinases at specific DNA loci by zinc-finger domain insertions. Mukhametzyanova L, Schmitt LT, Torres-Rivera J, Rojo-Romanos T, Lansing F, Paszkowski-Rogacz M, Hollak H, Brux M, Augsburg M, Schneider PM, Buchholz F. Nat Biotechnol. 2024 Dec;42(12):1844-1854. doi: 10.1038/s41587-023-02121-y. Epub 2024 Jan 31. PubMed |
| NSP6 inhibits the production of ACE2-containing exosomes to promote SARS-CoV-2 infectivity. Lv X, Chen R, Liang T, Peng H, Fang Q, Xiao S, Liu S, Hu M, Yu F, Cao L, Zhang Y, Pan T, Xi Z, Ding Y, Feng L, Zeng T, Huang W, Zhang H, Ma X. mBio. 2024 Mar 13;15(3):e0335823. doi: 10.1128/mbio.03358-23. Epub 2024 Feb 2. PubMed |
| NatD epigenetically activates FOXA2 expression to promote breast cancer progression by facilitating MMP14 expression. Xing M, Yao B, Xu J, Lu P, Li Q, Wu D, Chen B, Wei J, Su L, Zhao Q. iScience. 2024 Jan 9;27(2):108840. doi: 10.1016/j.isci.2024.108840. eCollection 2024 Feb 16. PubMed |
| Micronucleus is not a potent inducer of the cGAS/STING pathway. Sato Y, Hayashi MT. Life Sci Alliance. 2024 Feb 2;7(4):e202302424. doi: 10.26508/lsa.202302424. Print 2024 Apr. PubMed |
| Bone resorption by osteoclasts involves fine tuning of RHOA activity by its microtubule-associated exchange factor GEF-H1. Morel A, Douat C, Blangy A, Vives V. Front Physiol. 2024 Jan 19;15:1342024. doi: 10.3389/fphys.2024.1342024. eCollection 2024. PubMed |
| Differential histone acetylation and super-enhancer regulation underlie melanoma cell dedifferentiation. Mendelson K, Martin TC, Nguyen CB, Hsu M, Xu J, Lang C, Dummer R, Saenger Y, Messina JL, Sondak VK, Desman G, Hasson D, Bernstein E, Parsons RE, Celebi JT. JCI Insight. 2024 Feb 6;9(6):e166611. doi: 10.1172/jci.insight.166611. PubMed |
| Epithelial zonation along the mouse and human small intestine defines five discrete metabolic domains. Zwick RK, Kasparek P, Palikuqi B, Viragova S, Weichselbaum L, McGinnis CS, McKinley KL, Rathnayake A, Vaka D, Nguyen V, Trentesaux C, Reyes E, Gupta AR, Gartner ZJ, Locksley RM, Gardner JM, Itzkovitz S, Boffelli D, Klein OD. Nat Cell Biol. 2024 Feb;26(2):250-262. doi: 10.1038/s41556-023-01337-z. Epub 2024 Feb 6. PubMed |
| A small-molecule degrader selectively inhibits the growth of ALK-rearranged lung cancer with ceritinib resistance. Li X, Wang Z, Chen C, Yang F, Liu P, Fang S, Wang B, Chen S, Li X. iScience. 2024 Jan 26;27(2):109015. doi: 10.1016/j.isci.2024.109015. eCollection 2024 Feb 16. PubMed |
| Sirt6 ablation in the liver causes fatty liver that increases cancer risky by upregulating Serpina12. Li L, Zeng J, Zhang X, Feng Y, Lei JH, Xu X, Chen Q, Deng CX. EMBO Rep. 2024 Mar;25(3):1361-1386. doi: 10.1038/s44319-024-00071-3. Epub 2024 Feb 8. PubMed |
| SOX2 Expression Does Not Guarantee Cancer Stem Cell-like Characteristics in Lung Adenocarcinoma. Bae SH, Lee KY, Han S, Yun CW, Park C, Jang H. Cells. 2024 Jan 24;13(3):216. doi: 10.3390/cells13030216. PubMed |
| Mitochondrial outer membrane integrity regulates a ubiquitin-dependent and NF-kappaB-mediated inflammatory response. Vringer E, Heilig R, Riley JS, Black A, Cloix C, Skalka G, Montes-Gomez AE, Aguado A, Lilla S, Walczak H, Gyrd-Hansen M, Murphy DJ, Huang DT, Zanivan S, Tait SW. EMBO J. 2024 Mar;43(6):904-930. doi: 10.1038/s44318-024-00044-1. Epub 2024 Feb 9. PubMed |
| A methylation-phosphorylation switch controls EZH2 stability and hematopoiesis. Guo P, Lim RC, Rajawasam K, Trinh T, Sun H, Zhang H. Elife. 2024 Feb 12;13:e86168. doi: 10.7554/eLife.86168. PubMed |
| Aggregability of the SQSTM1/p62-based aggresome-like induced structures determines the sensitivity to parthanatos. Hamano S, Noguchi T, Asai Y, Ito R, Komatsu R, Sato T, Inoue A, Maruyama T, Kudo TA, Hirata Y, Shindo S, Uchida Y, Hwang GW, Matsuzawa A. Cell Death Discov. 2024 Feb 12;10(1):74. doi: 10.1038/s41420-024-01838-2. PubMed |
| Exploiting epigenetic targets to overcome taxane resistance in prostate cancer. Cevatemre B, Bulut I, Dedeoglu B, Isiklar A, Syed H, Bayram OY, Bagci-Onder T, Acilan C. Cell Death Dis. 2024 Feb 12;15(2):132. doi: 10.1038/s41419-024-06422-1. PubMed |
| Genomic and epigenomic basis of breast invasive lobular carcinomas lacking CDH1 genetic alterations. Dopeso H, Gazzo AM, Derakhshan F, Brown DN, Selenica P, Jalali S, Da Cruz Paula A, Marra A, da Silva EM, Basili T, Gusain L, Colon-Cartagena L, Bhaloo SI, Green H, Vanderbilt C, Oesterreich S, Grabenstetter A, Kuba MG, Ross D, Giri D, Wen HY, Zhang H, Brogi E, Weigelt B, Pareja F, Reis-Filho JS. NPJ Precis Oncol. 2024 Feb 12;8(1):33. doi: 10.1038/s41698-024-00508-x. PubMed |
| Hyaluronic acid turnover controls the severity of cerebral cavernous malformations in bioengineered human micro-vessels. Yordanov TE, Keyser MS, Enriquez Martinez MA, Esposito T, Tefft JB, Morris EK, Labzin LI, Stehbens SJ, Rowan AE, Hogan BM, Chen CS, Lauko J, Lagendijk AK. APL Bioeng. 2024 Feb 12;8(1):016108. doi: 10.1063/5.0159330. eCollection 2024 Mar. PubMed |
| Personalized allele-specific CRISPR-Cas9 strategies for myofibrillar myopathy 6. Shin JW, Kim KH, Lee Y, Choi DE, Lee JM. medRxiv [Preprint]. 2024 Feb 4:2024.02.03.24302252. doi: 10.1101/2024.02.03.24302252. PubMed |
| Asialoglycoprotein receptor 1 promotes SARS-CoV-2 infection of human normal hepatocytes. Yang X, Zheng X, Zhu Y, Zhao X, Liu J, Xun J, Yuan S, Chen J, Pan H, Yang J, Wang J, Liang Z, Shen X, Liang Y, Lin Q, Liang H, Li M, Peng F, Lu D, Xu J, Lu H, Jiang S, Zhao P, Zhu H. Signal Transduct Target Ther. 2024 Feb 14;9(1):42. doi: 10.1038/s41392-024-01754-y. PubMed |
| Exploiting spatiotemporal regulation of FZD5 during neural patterning for efficient ventral midbrain specification. Yang A, Chidiac R, Russo E, Steenland H, Pauli Q, Bonin R, Blazer LL, Adams JJ, Sidhu SS, Goeva A, Salahpour A, Angers S. Development. 2024 Mar 1;151(5):dev202545. doi: 10.1242/dev.202545. Epub 2024 Mar 4. PubMed |
| A landscape of gene expression regulation for synovium in arthritis. Jiang F, Hu SY, Tian W, Wang NN, Yang N, Dong SS, Song HM, Zhang DJ, Gao HW, Wang C, Wu H, He CY, Zhu DL, Chen XF, Guo Y, Yang Z, Yang TL. Nat Commun. 2024 Feb 15;15(1):1409. doi: 10.1038/s41467-024-45652-x. PubMed |
| Hexokinase 1 and 2 mediates glucose utilization to regulate the synthesis of kappa casein via ribosome protein subunit 6 kinase 1 in bovine mammary epithelial cells. Yang T, Guo J, Song H, Datsomor O, Chen Y, Jiang M, Zhan K, Zhao G. Anim Nutr. 2024 Jan 14;16:338-349. doi: 10.1016/j.aninu.2024.01.001. eCollection 2024 Mar. PubMed |
| In vivo CRISPR knockout screen identifies p47 as a suppressor of HER2+ breast cancer metastasis by regulating NEMO trafficking and autophagy flux. Hao M, Lu P, Sotropa S, Manupati K, Yeo SK, Guan JL. Cell Rep. 2024 Feb 27;43(2):113780. doi: 10.1016/j.celrep.2024.113780. Epub 2024 Feb 15. PubMed |
| Hijacking of nucleotide biosynthesis and deamidation-mediated glycolysis by an oncogenic herpesvirus. Wan Q, Tavakoli L, Wang TY, Tucker AJ, Zhou R, Liu Q, Feng S, Choi D, He Z, Gack MU, Zhao J. Nat Commun. 2024 Feb 16;15(1):1442. doi: 10.1038/s41467-024-45852-5. PubMed |
| SEL1L-HRD1 interaction is required to form a functional HRD1 ERAD complex. Lin LL, Wang HH, Pederson B, Wei X, Torres M, Lu Y, Li ZJ, Liu X, Mao H, Wang H, Zhou LE, Zhao Z, Sun S, Qi L. Nat Commun. 2024 Feb 16;15(1):1440. doi: 10.1038/s41467-024-45633-0. PubMed |
| HuR promotes castration-resistant prostate cancer progression by altering ERK5 activation via posttranscriptional regulation of BCAT1. You H, Song G, Xu Z, Chen S, Shen W, Liu H, Deng B, Li J, Huang G. J Transl Med. 2024 Feb 18;22(1):178. doi: 10.1186/s12967-024-04970-w. PubMed |
| DOT1L stimulates MYC/Mondo transcription factor activity by promoting its degradation cycle on chromatin. Sepulveda GP, Gushchanskaia ES, Mora-Martin A, Esse R, Nikorich I, Ceballos A, Kwan J, Blum BC, Dholiya P, Emili A, Perissi V, Cardamone MD, Grishok A. bioRxiv [Preprint]. 2024 Feb 7:2024.02.06.579191. doi: 10.1101/2024.02.06.579191. PubMed |
| alphaKG-mediated carnitine synthesis promotes homologous recombination via histone acetylation. Uboveja A, Huang Z, Buj R, Amalric A, Wang H, Tangudu NK, Cole AR, Megill E, Kantner D, Chatoff A, Ahmad H, Marcinkiewicz MM, Disharoon JA, Graff S, Dahl ES, Hempel N, Stallaert W, Sidoli S, Bitler BG, Long DT, Snyder NW, Aird KM. bioRxiv [Preprint]. 2024 Feb 11:2024.02.06.578742. doi: 10.1101/2024.02.06.578742. PubMed |
| Plasticity-induced repression of Irf6 underlies acquired resistance to cancer immunotherapy in pancreatic ductal adenocarcinoma. Kim IK, Diamond MS, Yuan S, Kemp SB, Kahn BM, Li Q, Lin JH, Li J, Norgard RJ, Thomas SK, Merolle M, Katsuda T, Tobias JW, Baslan T, Politi K, Vonderheide RH, Stanger BZ. Nat Commun. 2024 Feb 20;15(1):1532. doi: 10.1038/s41467-024-46048-7. PubMed |
| Influence of RNA circularity on Target RNA-Directed MicroRNA Degradation. Fuchs Wightman F, Lukin J, Giusti SA, Soutschek M, Bragado L, Pozzi B, Pierelli ML, Gonzalez P, Fededa JP, Schratt G, Fujiwara R, Wilusz JE, Refojo D, de la Mata M. Nucleic Acids Res. 2024 Apr 12;52(6):3358-3374. doi: 10.1093/nar/gkae094. PubMed |
| Selective CDK7 Inhibition Suppresses Cell Cycle Progression and MYC Signaling While Enhancing Apoptosis in Therapy-resistant Estrogen Receptor-positive Breast Cancer. Guarducci C, Nardone A, Russo D, Nagy Z, Heraud C, Grinshpun A, Zhang Q, Freelander A, Leventhal MJ, Feit A, Cohen Feit G, Feiglin A, Liu W, Hermida-Prado F, Kesten N, Ma W, De Angelis C, Morlando A, O'Donnell M, Naumenko S, Huang S, Nguyen QD, Huang Y, Malorni L, Bergholz JS, Zhao JJ, Fraenkel E, Lim E, Schiff R, Shapiro GI, Jeselsohn R. Clin Cancer Res. 2024 May 1;30(9):1889-1905. doi: 10.1158/1078-0432.CCR-23-2975. PubMed |
| Host ZCCHC3 blocks HIV-1 infection and production through a dual mechanism. Yi B, Tanaka YL, Cornish D, Kosako H, Butlertanaka EP, Sengupta P, Lippincott-Schwartz J, Hultquist JF, Saito A, Yoshimura SH. iScience. 2024 Feb 5;27(3):109107. doi: 10.1016/j.isci.2024.109107. eCollection 2024 Mar 15. PubMed |
| Porcine circovirus type 2 infection promotes the SUMOylation of nucleophosmin-1 to facilitate the viral circular single-stranded DNA replication. Du Q, Zhu L, Zhong J, Wei X, Zhang Q, Shi T, Han C, Yin X, Chen X, Tong D, Huang Y. PLoS Pathog. 2024 Feb 23;20(2):e1012014. doi: 10.1371/journal.ppat.1012014. eCollection 2024 Feb. PubMed |
| Human Betacoronavirus OC43 Interferes with the Integrated Stress Response Pathway in Infected Cells. Dolliver SM, Galbraith C, Khaperskyy DA. Viruses. 2024 Jan 31;16(2):212. doi: 10.3390/v16020212. PubMed |
| A tangible method to assess native ferroptosis suppressor activity. Nakamura T, Ito J, Mourao ASD, Wahida A, Nakagawa K, Mishima E, Conrad M. Cell Rep Methods. 2024 Mar 25;4(3):100710. doi: 10.1016/j.crmeth.2024.100710. Epub 2024 Feb 24. PubMed |
| KDM3B inhibitors disrupt the oncogenic activity of PAX3-FOXO1 in fusion-positive rhabdomyosarcoma. Kim YY, Gryder BE, Sinniah R, Peach ML, Shern JF, Abdelmaksoud A, Pomella S, Woldemichael GM, Stanton BZ, Milewski D, Barchi JJ Jr, Schneekloth JS Jr, Chari R, Kowalczyk JT, Shenoy SR, Evans JR, Song YK, Wang C, Wen X, Chou HC, Gangalapudi V, Esposito D, Jones J, Procter L, O'Neill M, Jenkins LM, Tarasova NI, Wei JS, McMahon JB, O'Keefe BR, Hawley RG, Khan J. Nat Commun. 2024 Feb 24;15(1):1703. doi: 10.1038/s41467-024-45902-y. PubMed |
| Translational response to mitochondrial stresses is orchestrated by tRNA modifications. Rashad S, Al-Mesitef S, Mousa A, Zhou Y, Ando D, Sun G, Fukuuchi T, Iwasaki Y, Xiang J, Byrne SR, Sun J, Maekawa M, Saigusa D, Begley TJ, Dedon PC, Niizuma K. bioRxiv [Preprint]. 2024 Feb 14:2024.02.14.580389. doi: 10.1101/2024.02.14.580389. PubMed |
| DNA-PK controls Apollo's access to leading-end telomeres. Sonmez C, Toia B, Eickhoff P, Matei AM, El Beyrouthy M, Wallner B, Douglas ME, de Lange T, Lottersberger F. Nucleic Acids Res. 2024 May 8;52(8):4313-4327. doi: 10.1093/nar/gkae105. PubMed |
| Microtubule disruption synergizes with STING signaling to show potent and broad-spectrum antiviral activity. Han J, Wang Z, Han F, Peng B, Du J, Zhang C. PLoS Pathog. 2024 Feb 26;20(2):e1012048. doi: 10.1371/journal.ppat.1012048. eCollection 2024 Feb. PubMed |
| The astrocyte-produced growth factor HB-EGF limits autoimmune CNS pathology. Linnerbauer M, Losslein L, Vandrey O, Peter A, Han Y, Tsaktanis T, Wogram E, Needhamsen M, Kular L, Nagel L, Zissler J, Andert M, Meszaros L, Hanspach J, Zuber F, Naumann UJ, Diebold M, Wheeler MA, Beyer T, Nirschl L, Cirac A, Laun FB, Gunther C, Winkler J, Bauerle T, Jagodic M, Hemmer B, Prinz M, Quintana FJ, Rothhammer V. Nat Immunol. 2024 Mar;25(3):432-447. doi: 10.1038/s41590-024-01756-6. Epub 2024 Feb 26. PubMed |
| E-cadherin loss drives diffuse-type gastric tumorigenesis via EZH2-mediated reprogramming. Zou G, Huang Y, Zhang S, Ko KP, Kim B, Zhang J, Venkatesan V, Pizzi MP, Fan Y, Jun S, Niu N, Wang H, Song S, Ajani JA, Park JI. J Exp Med. 2024 Apr 1;221(4):e20230561. doi: 10.1084/jem.20230561. Epub 2024 Feb 27. PubMed |
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| Apurinic/apyrimidinic endodeoxyribonuclease 1 (APE1) promotes stress granule formation via YBX1 phosphorylation in ovarian cancer. Mao S, Xie C, Liu Y, Zhao Y, Li M, Gao H, Xiao Y, Zou Y, Zheng Z, Gao Y, Xie J, Tian B, Wang L, Hua Y, Xu H. Cell Mol Life Sci. 2024 Mar 4;81(1):113. doi: 10.1007/s00018-023-05086-y. PubMed |
| Trans-lesion synthesis and mismatch repair pathway crosstalk defines chemoresistance and hypermutation mechanisms in glioblastoma. Cheng X, An J, Lou J, Gu Q, Ding W, Droby GN, Wang Y, Wang C, Gao Y, Anand JR, Shelton A, Satterlee AB, Mann B, Hsiao YC, Liu CW, Lu K, Hingtgen S, Wang J, Liu Z, Miller CR, Wu D, Vaziri C, Yang Y. Nat Commun. 2024 Mar 4;15(1):1957. doi: 10.1038/s41467-024-45979-5. PubMed |
| eEF1A2 promotes PTEN-GSK3beta-SCF complex-dependent degradation of Aurora kinase A and is inactivated in breast cancer. Treekitkarnmongkol W, Solis LM, Sankaran D, Gagea M, Singh PK, Mistry R, Nguyen T, Kai K, Liu J, Sasai K, Jitsumori Y, Liu J, Nagao N, Stossi F, Mancini MA, Wistuba II, Thompson AM, Lee JM, Cadinanos J, Wong KK, Abbott CM, Sahin AA, Liu S, Katayama H, Sen S. Sci Signal. 2024 Mar 5;17(826):eadh4475. doi: 10.1126/scisignal.adh4475. Epub 2024 Mar 5. PubMed |
| A deep learning model of tumor cell architecture elucidates response and resistance to CDK4/6 inhibitors. Park S, Silva E, Singhal A, Kelly MR, Licon K, Panagiotou I, Fogg C, Fong S, Lee JJY, Zhao X, Bachelder R, Parker BA, Yeung KT, Ideker T. Nat Cancer. 2024 Jul;5(7):996-1009. doi: 10.1038/s43018-024-00740-1. Epub 2024 Mar 5. PubMed |
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| Generation and characterization of three CRISPR/Cas9 edited RB1 null hiPSC lines for retinoblastoma disease modelling. Agrawal T, Maddileti S, Mariappan I. Stem Cell Res. 2024 Apr;76:103373. doi: 10.1016/j.scr.2024.103373. Epub 2024 Mar 2. PubMed |
| CRISPR/Cas9 model of prostate cancer identifies Kmt2c deficiency as a metastatic driver by Odam/Cabs1 gene cluster expression. Cai H, Zhang B, Ahrenfeldt J, Joseph JV, Riedel M, Gao Z, Thomsen SK, Christensen DS, Bak RO, Hager H, Vendelbo MH, Gao X, Birkbak N, Thomsen MK. Nat Commun. 2024 Mar 7;15(1):2088. doi: 10.1038/s41467-024-46370-0. PubMed |
| A SWI/SNF-dependent transcriptional regulation mediated by POU2AF2/C11orf53 at enhancer. Szczepanski A, Tsuboyama N, Lyu H, Wang P, Beytullahoglu O, Zhang T, Singer BD, Yue F, Zhao Z, Wang L. Nat Commun. 2024 Mar 7;15(1):2067. doi: 10.1038/s41467-024-46492-5. PubMed |
| Organelle resolved proteomics uncovers PLA2R1 as a novel cell surface marker required for chordoma growth. Khan S, Zuccato JA, Ignatchenko V, Singh O, Govindarajan M, Waas M, Mejia-Guerrero S, Gao A, Zadeh G, Kislinger T. Acta Neuropathol Commun. 2024 Mar 7;12(1):39. doi: 10.1186/s40478-024-01751-w. PubMed |
| USP22 regulates APL differentiation via PML-RARalpha stabilization and IFN repression. Kowald L, Roedig J, Karlowitz R, Wagner K, Smith S, Juretschke T, Beli P, Muller S, van Wijk SJL. Cell Death Discov. 2024 Mar 11;10(1):128. doi: 10.1038/s41420-024-01894-8. PubMed |
| RNA expression of 6 genes from metastatic mucosal gastric cancer serves as the global prognostic marker for gastric cancer with functional validation. Suh YS, Lee J, George J, Seol D, Jeong K, Oh SY, Bang C, Jun Y, Kong SH, Lee HJ, Kim JI, Kim WH, Yang HK, Lee C. Br J Cancer. 2024 May;130(9):1571-1584. doi: 10.1038/s41416-024-02642-6. Epub 2024 Mar 11. PubMed |
| Inhibition of 7-dehydrocholesterol reductase prevents hepatic ferroptosis under an active state of sterol synthesis. Yamada N, Karasawa T, Ito J, Yamamuro D, Morimoto K, Nakamura T, Komada T, Baatarjav C, Saimoto Y, Jinnouchi Y, Watanabe K, Miura K, Yahagi N, Nakagawa K, Matsumura T, Yamada KI, Ishibashi S, Sata N, Conrad M, Takahashi M. Nat Commun. 2024 Mar 12;15(1):2195. doi: 10.1038/s41467-024-46386-6. PubMed |
| Induction of Multiple Alternative Mitogenic Signaling Pathways Accompanies the Emergence of Drug-Tolerant Cancer Cells. Celeste FV, Powers S. Cancers (Basel). 2024 Feb 29;16(5):1001. doi: 10.3390/cancers16051001. PubMed |
| DPM1 modulates desmosomal adhesion and epidermal differentiation through SERPINB5. Rathod M, Franz H, Beyersdorfer V, Wanuske MT, Leal-Fischer K, Hanns P, Studle C, Zimmermann A, Buczak K, Schinner C, Spindler V. J Cell Biol. 2024 Apr 1;223(4):e202305006. doi: 10.1083/jcb.202305006. Epub 2024 Mar 13. PubMed |
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| p53 modulates kinase inhibitor resistance and lineage plasticity in NF1-related MPNSTs. Grit JL, McGee LE, Tovar EA, Essenburg CJ, Wolfrum E, Beddows I, Williams K, Sheridan RTC, Schipper JL, Adams M, Arumugam M, Vander Woude T, Gurunathan S, Field JM, Wulfkuhle J, Petricoin EF 3rd, Graveel CR, Steensma MR. Oncogene. 2024 May;43(19):1411-1430. doi: 10.1038/s41388-024-03000-9. Epub 2024 Mar 13. PubMed |
| Inhibition of BRD4 Attenuates ER Stress-induced Renal Ischemic-Reperfusion Injury. Diaz-Bulnes P, Rodriguez RM, Banon-Maneus E, Saiz ML, Bernet CR, Corte-Iglesias V, Ramirez-Bajo MJ, Lazo-Rodriguez M, Tamargo-Gomez I, Rodrigues-Diez RR, Sanz AB, Diaz-Corte C, Ruiz-Ortega M, Diekmann F, Aransay AM, Lopez-Larrea C, Suarez-Alvarez B. Int J Biol Sci. 2024 Feb 11;20(5):1547-1562. doi: 10.7150/ijbs.83040. eCollection 2024. PubMed |
| Housekeeping U1 snRNA facilitates antiviral innate immunity by promoting TRIM25-mediated RIG-I activation. Zhang F, Liu S, Qiao Z, Li L, Han Y, Sun J, Ge C, Zhu J, Li D, Yao H, Zhang H, Dai J, Yan Y, Chen Z, Yin L, Ma F. Cell Rep. 2024 Mar 26;43(3):113945. doi: 10.1016/j.celrep.2024.113945. Epub 2024 Mar 13. PubMed |
An efficient and cost-effective method for disrupting genes in RAW264.7 macrophages using CRISPR-Cas9.
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PLoS One. 2024 Mar 14;19(3):e0299513. doi: 10.1371/journal.pone.0299513. eCollection 2024.
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| Ubiquitin ligase subunit FBXO9 inhibits V-ATPase assembly and impedes lung cancer metastasis. Liu L, Chen X, Wu L, Huang K, Wang Z, Zheng Y, Zheng C, Zhang Z, Chen J, Wei J, Chen S, Jin W, Chen J, Wei D, Xu Y. Exp Hematol Oncol. 2024 Mar 14;13(1):32. doi: 10.1186/s40164-024-00497-4. PubMed |
| De novo steroidogenesis in tumor cells drives bone metastasis and osteoclastogenesis. Sandor LF, Huh JB, Benko P, Hiraga T, Poliska S, Dobo-Nagy C, Simpson JP, Homer NZM, Mahata B, Gyori DS. Cell Rep. 2024 Mar 26;43(3):113936. doi: 10.1016/j.celrep.2024.113936. Epub 2024 Mar 13. PubMed |
| Multimodal stimulation screens reveal unique and shared genes limiting T cell fitness. Lin CP, Levy PL, Alflen A, Apriamashvili G, Ligtenberg MA, Vredevoogd DW, Bleijerveld OB, Alkan F, Malka Y, Hoekman L, Markovits E, George A, Traets JJH, Krijgsman O, van Vliet A, Pozniak J, Pulido-Vicuna CA, de Bruijn B, van Hal-van Veen SE, Boshuizen J, van der Helm PW, Diaz-Gomez J, Warda H, Behrens LM, Mardesic P, Dehni B, Visser NL, Marine JC, Markel G, Faller WJ, Altelaar M, Agami R, Besser MJ, Peeper DS. Cancer Cell. 2024 Apr 8;42(4):623-645.e10. doi: 10.1016/j.ccell.2024.02.016. Epub 2024 Mar 14. PubMed |
| Activation of Bivalent Gene POU4F1 Promotes and Maintains Basal-like Breast Cancer. Zhang J, Miao N, Lao L, Deng W, Wang J, Zhu X, Huang Y, Lin H, Zeng W, Zhang W, Tan L, Yuan X, Zeng X, Zhu J, Chen X, Song E, Yang L, Nie Y, Huang D. Adv Sci (Weinh). 2024 May;11(20):e2307660. doi: 10.1002/advs.202307660. Epub 2024 Mar 16. PubMed |
| Nek2A prevents centrosome clustering and induces cell death in cancer cells via KIF2C interaction. Kalkan BM, Ozcan SC, Cicek E, Gonen M, Acilan C. Cell Death Dis. 2024 Mar 16;15(3):222. doi: 10.1038/s41419-024-06601-0. PubMed |
| Centriole structural integrity defects are a crucial feature of Hydrolethalus Syndrome. Curinha A, Huang Z, Anglen T, Strong MA, Gliech CR, Jewett CE, Friskes A, Holland AJ. bioRxiv [Preprint]. 2024 Mar 6:2024.03.06.583733. doi: 10.1101/2024.03.06.583733. PubMed |
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NFATC2IP is a mediator of SUMO-dependent genome integrity.
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Genes Dev. 2024 Apr 17;38(5-6):233-252. doi: 10.1101/gad.350914.123.
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| RBBP6 maintains glioblastoma stem cells through CPSF3-dependent alternative polyadenylation. Lin P, Chen W, Long Z, Yu J, Yang J, Xia Z, Wu Q, Min X, Tang J, Cui Y, Liu F, Wang C, Zheng J, Li W, Rich JN, Li L, Xie Q. Cell Discov. 2024 Mar 19;10(1):32. doi: 10.1038/s41421-024-00654-3. PubMed |
| FAM86A methylation of eEF2 links mRNA translation elongation to tumorigenesis. Francis JW, Hausmann S, Ikram S, Yin K, Mealey-Farr R, Flores NM, Trinh AT, Chasan T, Thompson J, Mazur PK, Gozani O. Mol Cell. 2024 May 2;84(9):1753-1763.e7. doi: 10.1016/j.molcel.2024.02.037. Epub 2024 Mar 19. PubMed |
| The homeobox transcription factor DUXBL controls exit from totipotency. Vega-Sendino M, Luttmann FF, Olbrich T, Chen Y, Kuenne C, Stein P, Tillo D, Carey GI, Zhong J, Savy V, Radonova L, Lu T, Saykali B, Kim KP, Domingo CN, Schuler L, Gunther S, Bentsen M, Bosnakovski D, Scholer H, Kyba M, Maity TK, Jenkins LM, Looso M, Williams CJ, Kim J, Ruiz S. Nat Genet. 2024 Apr;56(4):697-709. doi: 10.1038/s41588-024-01692-z. Epub 2024 Mar 20. PubMed |
| Dux activates metabolism-lactylation-MET network during early iPSC reprogramming with Brg1 as the histone lactylation reader. Hu X, Huang X, Yang Y, Sun Y, Zhao Y, Zhang Z, Qiu D, Wu Y, Wu G, Lei L. Nucleic Acids Res. 2024 Jun 10;52(10):5529-5548. doi: 10.1093/nar/gkae183. PubMed |
| Aberrant non-canonical NF-kappaB signalling reprograms the epigenome landscape to drive oncogenic transcriptomes in multiple myeloma. Ang DA, Carter JM, Deka K, Tan JHL, Zhou J, Chen Q, Chng WJ, Harmston N, Li Y. Nat Commun. 2024 Mar 21;15(1):2513. doi: 10.1038/s41467-024-46728-4. PubMed |
| Clinical drug screening reveals clofazimine potentiates the efficacy while reducing the toxicity of anti-PD-1 and CTLA-4 immunotherapy. Xue G, Li X, Kalim M, Fang J, Jiang Z, Zheng N, Wang Z, Li X, Abdelrahim M, He Z, Nikiforov M, Jin G, Lu Y. Cancer Cell. 2024 May 13;42(5):780-796.e6. doi: 10.1016/j.ccell.2024.03.001. Epub 2024 Mar 21. PubMed |
| AURKA emerges as a vulnerable target for KEAP1-deficient non-small cell lung cancer by activation of asparagine synthesis. Deng B, Liu F, Chen N, Li X, Lei J, Chen N, Wu J, Wang X, Lu J, Fang M, Chen A, Zhang Z, He B, Yan M, Zhang Y, Wang Z, Liu Q. Cell Death Dis. 2024 Mar 23;15(3):233. doi: 10.1038/s41419-024-06577-x. PubMed |
| Disruption of polyunsaturated fatty acid biosynthesis drives STING-dependent acute myeloid leukemia cell maturation and death. Kanefsky J, Basse M, Sokei J, di Martino O, Valin L, Jaspers Y, Martinez E, Huhn J, Di Marcantonio D, Magee JA, Goldman AR, Tang HY, Ferraro F, Kemp S, Wiest DL, Sykes SM. J Biol Chem. 2024 May;300(5):107214. doi: 10.1016/j.jbc.2024.107214. Epub 2024 Mar 22. PubMed |
| Induction of Viral Mimicry Upon Loss of DHX9 and ADAR1 in Breast Cancer Cells. Cottrell KA, Ryu S, Pierce JR, Soto Torres L, Bohlin HE, Schab AM, Weber JD. Cancer Res Commun. 2024 Apr 4;4(4):986-1003. doi: 10.1158/2767-9764.CRC-23-0488. PubMed |
| Induction of immortal-like and functional CAR T cells by defined factors. Wang L, Jin G, Zhou Q, Liu Y, Zhao X, Li Z, Yin N, Peng M. J Exp Med. 2024 May 6;221(5):e20232368. doi: 10.1084/jem.20232368. Epub 2024 Mar 26. PubMed |
| Targeting the receptor tyrosine kinase MerTK shows therapeutic value in gastric adenocarcinoma. Wirsik NM, Chen M, He L, Yasar U, Gaukel J, Quaas A, Nienhuser H, Leugner E, Yuan S, Schleussner N, Jung JO, Plucker JS, Schneider M, Schmidt T. Cancer Med. 2024 Apr;13(7):e6866. doi: 10.1002/cam4.6866. PubMed |
| Control of cell proliferation by memories of mitosis. Meitinger F, Belal H, Davis RL, Martinez MB, Shiau AK, Oegema K, Desai A. Science. 2024 Mar 29;383(6690):1441-1448. doi: 10.1126/science.add9528. Epub 2024 Mar 28. PubMed |
| Initiation of a ZAKalpha-dependent ribotoxic stress response by the innate immunity endoribonuclease RNase L. Xi J, Snieckute G, Martinez JF, Arendrup FSW, Asthana A, Gaughan C, Lund AH, Bekker-Jensen S, Silverman RH. Cell Rep. 2024 Apr 23;43(4):113998. doi: 10.1016/j.celrep.2024.113998. Epub 2024 Mar 28. PubMed |
| Depletion of Mettl3 in cholinergic neurons causes adult-onset neuromuscular degeneration. Dermentzaki G, Furlan M, Tanaka I, Leonardi T, Rinchetti P, Passos PMS, Bastos A, Ayala YM, Hanna JH, Przedborski S, Bonanomi D, Pelizzola M, Lotti F. Cell Rep. 2024 Apr 23;43(4):113999. doi: 10.1016/j.celrep.2024.113999. Epub 2024 Mar 30. PubMed |
| Development of an orally bioavailable mSWI/SNF ATPase degrader and acquired mechanisms of resistance in prostate cancer. He T, Cheng C, Qiao Y, Cho H, Young E, Mannan R, Mahapatra S, Miner SJ, Zheng Y, Kim N, Zeng VZ, Wisniewski JP, Hou S, Jackson B, Cao X, Su F, Wang R, Chang Y, Kuila B, Mukherjee S, Dukare S, Aithal KB, D S S, Abbineni C, Vaishampayan U, Lyssiotis CA, Parolia A, Xiao L, Chinnaiyan AM. Proc Natl Acad Sci U S A. 2024 Apr 9;121(15):e2322563121. doi: 10.1073/pnas.2322563121. Epub 2024 Apr 1. PubMed |
| iRhom2 regulates ectodomain shedding and surface expression of the major histocompatibility complex (MHC) class I. Calligaris M, Spano DP, Bonelli S, Muller SA, Carcione C, D'apolito D, Amico G, Miele M, Di Bella M, Zito G, Nuti E, Rossello A, Blobel CP, Lichtenthaler SF, Scilabra SD. Cell Mol Life Sci. 2024 Apr 4;81(1):163. doi: 10.1007/s00018-024-05201-7. PubMed |
| Genome-wide CRISPR screens identify PKMYT1 as a therapeutic target in pancreatic ductal adenocarcinoma. Wang S, Xiong Y, Luo Y, Shen Y, Zhang F, Lan H, Pang Y, Wang X, Li X, Zheng X, Lu X, Liu X, Cheng Y, Wu T, Dong Y, Lu Y, Cui J, Jia X, Yang S, Wang L, Wang Y. EMBO Mol Med. 2024 May;16(5):1115-1142. doi: 10.1038/s44321-024-00060-y. Epub 2024 Apr 3. PubMed |
| Targeting the GPI transamidase subunit GPAA1 abrogates the CD24 immune checkpoint in ovarian cancer. Mishra AK, Ye T, Banday S, Thakare RP, Su CT, Pham NNH, Ali A, Kulshreshtha A, Chowdhury SR, Simone TM, Hu K, Zhu LJ, Eisenhaber B, Deibler SK, Simin K, Thompson PR, Kelliher MA, Eisenhaber F, Malonia SK, Green MR. Cell Rep. 2024 Apr 23;43(4):114041. doi: 10.1016/j.celrep.2024.114041. Epub 2024 Apr 3. PubMed |
| Genetic and pharmacological reduction of CDK14 mitigates synucleinopathy. Parmasad JA, Ricke KM, Nguyen B, Stykel MG, Buchner-Duby B, Bruce A, Geertsma HM, Lian E, Lengacher NA, Callaghan SM, Joselin A, Tomlinson JJ, Schlossmacher MG, Stanford WL, Ma J, Brundin P, Ryan SD, Rousseaux MWC. Cell Death Dis. 2024 Apr 4;15(4):246. doi: 10.1038/s41419-024-06534-8. PubMed |
DePARylation is critical for S phase progression and cell survival.
Nie L, Wang C, Huang M, Liu X, Feng X, Tang M, Li S, Hang Q, Teng H, Shen X, Ma L, Gan B, Chen J.
Elife. 2024 Apr 5;12:RP89303. doi: 10.7554/eLife.89303.
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| Tumor cell-intrinsic epigenetic dysregulation shapes cancer-associated fibroblasts heterogeneity to metabolically support pancreatic cancer. Niu N, Shen X, Wang Z, Chen Y, Weng Y, Yu F, Tang Y, Lu P, Liu M, Wang L, Sun Y, Yang M, Shen B, Jin J, Lu Z, Jiang K, Shi Y, Xue J. Cancer Cell. 2024 May 13;42(5):869-884.e9. doi: 10.1016/j.ccell.2024.03.005. Epub 2024 Apr 4. PubMed |
| Identifying human pre-mRNA cleavage and polyadenylation factors by genome-wide CRISPR screens using a dual fluorescence readthrough reporter. Ni Z, Ahmed N, Nabeel-Shah S, Guo X, Pu S, Song J, Marcon E, Burke GL, Tong AHY, Chan K, Ha KCH, Blencowe BJ, Moffat J, Greenblatt JF. Nucleic Acids Res. 2024 May 8;52(8):4483-4501. doi: 10.1093/nar/gkae240. PubMed |
| ZNF397 Deficiency Triggers TET2-Driven Lineage Plasticity and AR-Targeted Therapy Resistance in Prostate Cancer. Xu Y, Yang Y, Wang Z, Sjostrom M, Jiang Y, Tang Y, Cheng S, Deng S, Wang C, Gonzalez J, Johnson NA, Li X, Li X, Metang LA, Mukherji A, Xu Q, Tirado CR, Wainwright G, Yu X, Barnes S, Hofstad M, Chen Y, Zhu H, Hanker AB, Raj GV, Zhu G, He HH, Wang Z, Arteaga CL, Liang H, Feng FY, Wang Y, Wang T, Mu P. Cancer Discov. 2024 Aug 2;14(8):1496-1521. doi: 10.1158/2159-8290.CD-23-0539. PubMed |
| Genetic interactions reveal distinct biological and therapeutic implications in breast cancer. Lin CJ, Jin X, Ma D, Chen C, Ou-Yang Y, Pei YC, Zhou CZ, Qu FL, Wang YJ, Liu CL, Fan L, Hu X, Shao ZM, Jiang YZ. Cancer Cell. 2024 Apr 8;42(4):701-719.e12. doi: 10.1016/j.ccell.2024.03.006. PubMed |
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| Dynamic control of gene expression by ISGF3 and IRF1 during IFNbeta and IFNgamma signaling. Ravi Sundar Jose Geetha A, Fischer K, Babadei O, Smesnik G, Vogt A, Platanitis E, Muller M, Farlik M, Decker T. EMBO J. 2024 Jun;43(11):2233-2263. doi: 10.1038/s44318-024-00092-7. Epub 2024 Apr 24. PubMed |
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| A MTA2-SATB2 chromatin complex restrains colonic plasticity toward small intestine by retaining HNF4A at colonic chromatin. Gu W, Huang X, Singh PNP, Li S, Lan Y, Deng M, Lacko LA, Gomez-Salinero JM, Rafii S, Verzi MP, Shivdasani RA, Zhou Q. Nat Commun. 2024 Apr 27;15(1):3595. doi: 10.1038/s41467-024-47738-y. PubMed |
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| Targeting pyruvate dehydrogenase kinase 1 overcomes EGFR C797S mutation-driven osimertinib resistance in non-small cell lung cancer. Park W, Wei S, Xie CL, Han JH, Kim BS, Kim B, Jin JS, Yang ES, Cho MK, Ryu D, Yang HX, Bae SJ, Ha KT. Exp Mol Med. 2024 May;56(5):1137-1149. doi: 10.1038/s12276-024-01221-2. Epub 2024 May 1. PubMed |
| PRMT1 promotes epigenetic reprogramming associated with acquired chemoresistance in pancreatic cancer. Nguyen CDK, Colon-Emeric BA, Murakami S, Shujath MNY, Yi C. Cell Rep. 2024 May 28;43(5):114176. doi: 10.1016/j.celrep.2024.114176. Epub 2024 Apr 30. PubMed |
| Long-term expandable mouse and human-induced nephron progenitor cells enable kidney organoid maturation and modeling of plasticity and disease. Huang B, Zeng Z, Kim S, Fausto CC, Koppitch K, Li H, Li Z, Chen X, Guo J, Zhang CC, Ma T, Medina P, Schreiber ME, Xia MW, Vonk AC, Xiang T, Patel T, Li Y, Parvez RK, Der B, Chen JH, Liu Z, Thornton ME, Grubbs BH, Diao Y, Dou Y, Gnedeva K, Ying Q, Pastor-Soler NM, Fei T, Hallows KR, Lindstrom NO, McMahon AP, Li Z. Cell Stem Cell. 2024 Jun 6;31(6):921-939.e17. doi: 10.1016/j.stem.2024.04.002. Epub 2024 Apr 30. PubMed |
| The epigenetic regulators EP300/CREBBP represent promising therapeutic targets in MLL-rearranged acute myeloid leukemia. Wu W, Jiang Y, Xing D, Zhai Y, Sun H, He X, Luo K, Xu P, Pan F, Dong G, Ren G, Zhao Z. Cell Death Discov. 2024 May 1;10(1):206. doi: 10.1038/s41420-024-01940-5. PubMed |
| The nonvesicular sterol transporter Aster-C plays a minor role in whole body cholesterol balance. Banerjee R, Hohe RC, Cao S, Jung BM, Horak AJ, Ramachandiran I, Massey WJ, Varadharajan V, Zajczenko NI, Burrows AC, Dutta S, Goudarzi M, Mahen K, Carter A, Helsley RN, Gordon SM, Morton RE, Strauch C, Willard B, Gogonea CB, Gogonea V, Pedrelli M, Parini P, Brown JM. Front Physiol. 2024 Apr 17;15:1371096. doi: 10.3389/fphys.2024.1371096. eCollection 2024. PubMed |
Prime editing functionally corrects cystic fibrosis-causing CFTR mutations in human organoids and airway epithelial cells.
Bulcaen M, Kortleven P, Liu RB, Maule G, Dreano E, Kelly M, Ensinck MM, Thierie S, Smits M, Ciciani M, Hatton A, Chevalier B, Ramalho AS, Casadevall I Solvas X, Debyser Z, Vermeulen F, Gijsbers R, Sermet-Gaudelus I, Cereseto A, Carlon MS.
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| De novo generation of multi-target compounds using deep generative chemistry. Munson BP, Chen M, Bogosian A, Kreisberg JF, Licon K, Abagyan R, Kuenzi BM, Ideker T. Nat Commun. 2024 May 6;15(1):3636. doi: 10.1038/s41467-024-47120-y. PubMed |
| Functional genomics screens reveal a role for TBC1D24 and SV2B in antibody-dependent enhancement of dengue virus infection. Belmont L, Contreras M, Cartwright-Acar CH, Marceau CD, Agrawal A, Levoir LM, Lubow J, Goo L. bioRxiv [Preprint]. 2024 Apr 27:2024.04.26.591029. doi: 10.1101/2024.04.26.591029. PubMed |
| Senataxin deficiency disrupts proteostasis through nucleolar ncRNA-driven protein aggregation. Wen X, Xu H, Woolley PR, Conway OM, Yao J, Matouschek A, Lambowitz AM, Paull TT. J Cell Biol. 2024 Jul 1;223(7):e202309036. doi: 10.1083/jcb.202309036. Epub 2024 May 8. PubMed |
| Genomic context- and H2AK119 ubiquitination-dependent inheritance of human Polycomb silencing. Shafiq TA, Yu J, Feng W, Zhang Y, Zhou H, Paulo JA, Gygi SP, Moazed D. Sci Adv. 2024 May 10;10(19):eadl4529. doi: 10.1126/sciadv.adl4529. Epub 2024 May 8. PubMed |
| Prolonged depletion of profilin 1 or F-actin causes an adaptive response in microtubules. Cisterna BA, Skruber K, Jane ML, Camesi CI, Nguyen ID, Liu TM, Warp PV, Black JB, Butler MT, Bear JE, Mor DE, Read TA, Vitriol EA. J Cell Biol. 2024 Jul 1;223(7):e202309097. doi: 10.1083/jcb.202309097. Epub 2024 May 9. PubMed |
| Cyclin-dependent kinase 12 deficiency reprogrammes cellular metabolism to alleviate ferroptosis potential and promote the progression of castration-resistant prostate cancer. Zhang H, Zhou Y, Feng Y, Hou W, Chen Y, Xing Z, Zhang Y, Wei Q, Yin Y, Guo J, Hu H. Clin Transl Med. 2024 May;14(5):e1678. doi: 10.1002/ctm2.1678. PubMed |
| Tumors cells with mismatch repair deficiency induce hyperactivation of pyroptosis resistant to cell membrane damage but are more sensitive to co-treatment of IFN-gamma and TNF-alpha to PANoptosis. Li H, Ni H, Li Y, Zhou A, Qin X, Li Y, Che L, Mo H, Qin C, Li J. Cell Death Discov. 2024 May 13;10(1):227. doi: 10.1038/s41420-024-01984-7. PubMed |
| l-2-Hydroxyglutarate remodeling of the epigenome and epitranscriptome creates a metabolic vulnerability in kidney cancer models. Kundu A, Brinkley GJ, Nam H, Karki S, Kirkman R, Pandit M, Shim E, Widden H, Liu J, Heidarian Y, Mahmoudzadeh NH, Fitt AJ, Absher D, Ding HF, Crossman DK, Placzek WJ, Locasale JW, Rakheja D, McConathy JE, Ramachandran R, Bae S, Tennessen JM, Sudarshan S. J Clin Invest. 2024 May 14;134(13):e171294. doi: 10.1172/JCI171294. PubMed |
| Genome-wide CRISPR screens in spheroid culture reveal that the tumor suppressor LKB1 inhibits growth via the PIKFYVE lipid kinase. Ferrarone JR, Thomas J, Unni AM, Zheng Y, Nagiec MJ, Gardner EE, Mashadova O, Li K, Koundouros N, Montalbano A, Mustafa M, Cantley LC, Blenis J, Sanjana NE, Varmus H. Proc Natl Acad Sci U S A. 2024 May 21;121(21):e2403685121. doi: 10.1073/pnas.2403685121. Epub 2024 May 14. PubMed |
| Osr2 functions as a biomechanical checkpoint to aggravate CD8(+) T cell exhaustion in tumor. Zhang J, Li J, Hou Y, Lin Y, Zhao H, Shi Y, Chen K, Nian C, Tang J, Pan L, Xing Y, Gao H, Yang B, Song Z, Cheng Y, Liu Y, Sun M, Linghu Y, Li J, Huang H, Lai Z, Zhou Z, Li Z, Sun X, Chen Q, Su D, Li W, Peng Z, Liu P, Chen W, Huang H, Chen Y, Xiao B, Ye L, Chen L, Zhou D. Cell. 2024 Jun 20;187(13):3409-3426.e24. doi: 10.1016/j.cell.2024.04.023. Epub 2024 May 13. PubMed |
| H2A.Z chaperones converge on E2F target genes for melanoma cell proliferation. Jostes S, Vardabasso C, Dong J, Carcamo S, Singh R, Phelps R, Meadows A, Grossi E, Hasson D, Bernstein E. Genes Dev. 2024 May 21;38(7-8):336-353. doi: 10.1101/gad.351318.123. PubMed |
| PAX6 promotes neuroendocrine phenotypes of prostate cancer via enhancing MET/STAT5A-mediated chromatin accessibility. Jing N, Du X, Liang Y, Tao Z, Bao S, Xiao H, Dong B, Gao WQ, Fang YX. J Exp Clin Cancer Res. 2024 May 15;43(1):144. doi: 10.1186/s13046-024-03064-1. PubMed |
| Cysteine Rich Intestinal Protein 2 is a copper-responsive regulator of skeletal muscle differentiation. Verdejo-Torres O, Klein DC, Novoa-Aponte L, Carrazco-Carrillo J, Bonilla-Pinto D, Rivera A, Fitisemanu F, Jimenez-Gonzalez ML, Flinn L, Pezacki AT, Lanzirotti A, Ortiz-Frade LA, Chang CJ, Navea JG, Blaby-Haas C, Hainer SJ, Padilla-Benavides T. bioRxiv [Preprint]. 2024 May 5:2024.05.03.592485. doi: 10.1101/2024.05.03.592485. PubMed |
| Octyl itaconate enhances VSVDelta51 oncolytic virotherapy by multitarget inhibition of antiviral and inflammatory pathways. Kurmasheva N, Said A, Wong B, Kinderman P, Han X, Rahimic AHF, Kress A, Carter-Timofte ME, Holm E, van der Horst D, Kollmann CF, Liu Z, Wang C, Hoang HD, Kovalenko E, Chrysopoulou M, Twayana KS, Ottosen RN, Svenningsen EB, Begnini F, Kiib AE, Kromm FEH, Weiss HJ, Di Carlo D, Muscolini M, Higgins M, van der Heijden M, Bardoul A, Tong T, Ozsvar A, Hou WH, Schack VR, Holm CK, Zheng Y, Ruzek M, Kalucka J, de la Vega L, Elgaher WAM, Korshoej AR, Lin R, Hiscott J, Poulsen TB, O'Neill LA, Roy DG, Rinschen MM, van Montfoort N, Diallo JS, Farin HF, Alain T, Olagnier D. Nat Commun. 2024 May 15;15(1):4096. doi: 10.1038/s41467-024-48422-x. PubMed |
| Endocardial HDAC3 is required for myocardial trabeculation. Jang J, Bentsen M, Kim YJ, Kim E, Garg V, Cai CL, Looso M, Li D. Nat Commun. 2024 May 16;15(1):4166. doi: 10.1038/s41467-024-48362-6. PubMed |
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| Ileal Crohn's Disease Exhibits Reduced Activity of Phospholipase C-beta3-Dependent Wnt/beta-Catenin Signaling Pathway. Ando T, Takazawa I, Spencer ZT, Ito R, Tomimori Y, Mikulski Z, Matsumoto K, Ishitani T, Denson LA, Kawakami Y, Kawakami Y, Kitaura J, Ahmed Y, Kawakami T. Cells. 2024 Jun 5;13(11):986. doi: 10.3390/cells13110986. PubMed |
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AMPK targets PDZD8 to trigger carbon source shift from glucose to glutamine.
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| RUVBL1/2 Blockade Targets YTHDF1 Activity to Suppress m6A-Dependent Oncogenic Translation and Colorectal Tumorigenesis. Chen D, Ji F, Zhou Q, Cheung H, Pan Y, Lau HC, Liang C, Yang Z, Huang P, Wei Q, Cheung AH, Kang W, Chen H, Yu J, Wong CC. Cancer Res. 2024 Sep 4;84(17):2856-2872. doi: 10.1158/0008-5472.CAN-23-2081. PubMed |
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pLxIS-containing domains are biochemically flexible regulators of interferons and metabolism.
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| Systematic transcriptome profiling of hPSC-derived osteoblasts unveils CORIN's mastery in governing osteogenesis through CEBPD modulation. Zhu D, Huang MF, Xu A, Gao X, Huang YW, Phan TTT, Lu L, Chi TY, Dai Y, Pang LK, Gingold JA, Tu J, Huo Z, Bazer DA, Shoemaker R, Wang J, Ambrose CG, Shen J, Kameoka J, Zhao Z, Wang LL, Zhang Y, Zhao R, Lee DF. J Biol Chem. 2024 Aug;300(8):107494. doi: 10.1016/j.jbc.2024.107494. Epub 2024 Jun 24. PubMed |
| Evolution of STAT2 resistance to flavivirus NS5 occurred multiple times despite genetic constraints. Veit EC, Salim MS, Jung MJ, Richardson RB, Boys IN, Quinlan M, Barrall EA, Bednarski E, Hamilton RE, Kikawa C, Elde NC, Garcia-Sastre A, Evans MJ. Nat Commun. 2024 Jun 26;15(1):5426. doi: 10.1038/s41467-024-49758-0. PubMed |
| 3D Chromatin Alteration by Disrupting beta-Catenin/CBP Interaction Is Enriched with Insulin Signaling in Pancreatic Cancer. Zhou Y, He Z, Li T, Choppavarapu L, Hu X, Cao R, Leone GW, Kahn M, Jin VX. Cancers (Basel). 2024 Jun 12;16(12):2202. doi: 10.3390/cancers16122202. PubMed |
| Tripartite Motif-Containing Protein 65 (TRIM65) Inhibits Hepatitis B Virus Transcription. Shen S, Yan R, Xie Z, Yu X, Liang H, You Q, Zhang H, Hou J, Zhang X, Liu Y, Sun J, Guo H. Viruses. 2024 May 31;16(6):890. doi: 10.3390/v16060890. PubMed |
| CRISPR-Cas9 screening reveals a distinct class of MHC-I binders with precise HLA-peptide recognition. Schoufour TAW, van der Plas-van Duijn A, Derksen I, Melgers M, van Veenendaal JMF, Lensen C, Heemskerk MHM, Neefjes J, Wijdeven RHM, Scheeren FA. iScience. 2024 May 27;27(6):110120. doi: 10.1016/j.isci.2024.110120. eCollection 2024 Jun 21. PubMed |
| MAST4 regulates stem cell maintenance with DLX3 for epithelial development and amelogenesis. Lee DJ, Kim P, Kim HY, Park J, Lee SJ, An H, Heo JS, Lee MJ, Ohshima H, Mizuno S, Takahashi S, Jung HS, Kim SJ. Exp Mol Med. 2024 Jul;56(7):1606-1619. doi: 10.1038/s12276-024-01264-5. Epub 2024 Jul 1. PubMed |
| TRMT10A dysfunction perturbs codon translation of initiator methionine and glutamine and impairs brain functions in mice. Tresky R, Miyamoto Y, Nagayoshi Y, Yabuki Y, Araki K, Takahashi Y, Komohara Y, Ge H, Nishiguchi K, Fukuda T, Kaneko H, Maeda N, Matsuura J, Iwasaki S, Sakakida K, Shioda N, Wei FY, Tomizawa K, Chujo T. Nucleic Acids Res. 2024 Aug 27;52(15):9230-9246. doi: 10.1093/nar/gkae520. PubMed |
| Metabolic stress induces a double-positive feedback loop between AMPK and SQSTM1/p62 conferring dual activation of AMPK and NFE2L2/NRF2 to synergize antioxidant defense. Choi EJ, Oh HT, Lee SH, Zhang CS, Li M, Kim SY, Park S, Chang TS, Lee BH, Lin SC, Jeon SM. Autophagy. 2024 Nov;20(11):2490-2510. doi: 10.1080/15548627.2024.2374692. Epub 2024 Jul 10. PubMed |
| The histamine receptor H1 acts as an alternative receptor for SARS-CoV-2. Yu F, Liu X, Ou H, Li X, Liu R, Lv X, Xiao S, Hu M, Liang T, Chen T, Wei X, Zhang Z, Liu S, Liu H, Zhu Y, Liu G, Tu T, Li P, Zhang H, Pan T, Ma X. mBio. 2024 Aug 14;15(8):e0108824. doi: 10.1128/mbio.01088-24. Epub 2024 Jul 2. PubMed |
| Leveraging biotin-based proximity labeling to identify cellular factors governing early alphaherpesvirus infection. Quan J, Fan Q, Simons LM, Smukowski SN, Pegg C, Longnecker R, Savas JN, Hultquist JF, Smith GA. mBio. 2024 Aug 14;15(8):e0144524. doi: 10.1128/mbio.01445-24. Epub 2024 Jul 2. PubMed |
| An HIV-1 CRISPR-Cas9 membrane trafficking screen reveals a role for PICALM intersecting endolysosomes and immunity. Guizar P, Abdalla AL, Monette A, Davis K, Caballero RE, Niu M, Liu X, Ajibola O, Murooka TT, Liang C, Mouland AJ. iScience. 2024 May 27;27(6):110131. doi: 10.1016/j.isci.2024.110131. eCollection 2024 Jun 21. PubMed |
| The two-faced role of RNA methyltransferase METTL3 on cellular response to cisplatin in head and neck squamous cell carcinoma in vitro model. Ostrowska K, Rawluszko-Wieczorek AA, Ostapowicz J, Suchorska WM, Golusinski W. Front Oncol. 2024 Jun 19;14:1402126. doi: 10.3389/fonc.2024.1402126. eCollection 2024. PubMed |
SigmaR1 shapes rough endoplasmic reticulum membrane sheets.
Sawyer EM, Jensen LE, Meehl JB, Larsen KP, Petito DA, Hurley JH, Voeltz GK.
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Associated Plasmids |
| KAT6A Condensates Impair PARP1 Trapping of PARP Inhibitors in Ovarian Cancer. Zhan Z, Zhang J, Liang H, Wang C, Hong L, Liu W. Adv Sci (Weinh). 2024 Sep;11(34):e2400140. doi: 10.1002/advs.202400140. Epub 2024 Jul 8. PubMed |
| The caspase-activated DNase promotes cellular senescence. Haimovici A, Rupp V, Amer T, Moeed A, Weber A, Hacker G. EMBO J. 2024 Aug;43(16):3523-3544. doi: 10.1038/s44318-024-00163-9. Epub 2024 Jul 8. PubMed |
| A non-canonical role for a small nucleolar RNA in ribosome biogenesis and senescence. Cheng Y, Wang S, Zhang H, Lee JS, Ni C, Guo J, Chen E, Wang S, Acharya A, Chang TC, Buszczak M, Zhu H, Mendell JT. Cell. 2024 Aug 22;187(17):4770-4789.e23. doi: 10.1016/j.cell.2024.06.019. Epub 2024 Jul 8. PubMed |
| Synthetic lethal CRISPR screen identifies a cancer cell-intrinsic role of PD-L1 in regulation of vulnerability to ferroptosis. Feng YY, Li YC, Liu HM, Xu R, Liu YT, Zhang W, Yang HY, Chen G. Cell Rep. 2024 Jul 23;43(7):114477. doi: 10.1016/j.celrep.2024.114477. Epub 2024 Jul 11. PubMed |
| PP2A B55alpha inhibits epithelial-mesenchymal transition via regulation of Slug expression in non-small cell lung cancer. Singh D, Qiu Z, Jonathan SM, Fa P, Thomas H, Prasad CB, Cai S, Wang JJ, Yan C, Zhang X, Venere M, Li Z, Sizemore ST, Wang QE, Zhang J. Cancer Lett. 2024 Aug 28;598:217110. doi: 10.1016/j.canlet.2024.217110. Epub 2024 Jul 8. PubMed |
| The COMPASS complex maintains the metastatic capacity imparted by a subpopulation of cells in UPS. Ban GI, Puviindran V, Xiang Y, Nadesan P, Tang J, Ou J, Guardino N, Nakagawa M, Browne M, Wallace A, Ishikawa K, Shimada E, Martin JT, Diao Y, Kirsch DG, Alman BA. iScience. 2024 Jun 5;27(7):110187. doi: 10.1016/j.isci.2024.110187. eCollection 2024 Jul 19. PubMed |
| BL-918 activates PINK1/Parkin signaling pathway to ameliorate the progression of Parkinson's disease. Wang Y, Luo S, Su H, Wang Z, Chu L, Zhang C. J Biol Chem. 2024 Aug;300(8):107543. doi: 10.1016/j.jbc.2024.107543. Epub 2024 Jul 9. PubMed |
| Local vascular Klotho mediates diabetes-induced atherosclerosis via ERK1/2 and PI3-kinase-dependent signaling pathways. Ajay AK, Zhu LJ, Zhao L, Liu Q, Ding Y, Chang YC, Shah SI, Hsiao LL. Atherosclerosis. 2024 Sep;396:118531. doi: 10.1016/j.atherosclerosis.2024.118531. Epub 2024 Jul 3. PubMed |
| Phosphorylation of GCN2 by mTOR confers adaptation to conditions of hyper-mTOR activation under stress. Darawshi O, Yassin O, Shmuel M, Wek RC, Mahdizadeh SJ, Eriksson LA, Hatzoglou M, Tirosh B. J Biol Chem. 2024 Aug;300(8):107575. doi: 10.1016/j.jbc.2024.107575. Epub 2024 Jul 14. PubMed |
| Chemical genetic screens reveal defective lysosomal trafficking as synthetic lethal with NF1 loss. Bouley SJ, Grassetti AV, Allaway RJ, Wood MD, Hou HW, Burdon Dasbach IR, Seibel W, Wu J, Gerber SA, Dragnev KH, Walker JA, Sanchez Y. J Cell Sci. 2024 Aug 1;137(15):jcs262343. doi: 10.1242/jcs.262343. Epub 2024 Aug 14. PubMed |
| Repression of mRNA translation initiation by GIGYF1 via disrupting the eIF3-eIF4G1 interaction. Choi JH, Luo J, Hesketh GG, Guo S, Pistofidis A, Ladak RJ, An Y, Naeli P, Alain T, Schmeing TM, Gingras AC, Duchaine T, Zhang X, Sonenberg N, Jafarnejad SM. Sci Adv. 2024 Jul 19;10(29):eadl5638. doi: 10.1126/sciadv.adl5638. Epub 2024 Jul 17. PubMed |
| Netrin signaling mediates survival of dormant epithelial ovarian cancer cells. Perampalam P, MacDonald JI, Zakirova K, Passos DT, Wasif S, Ramos-Valdes Y, Hervieu M, Mehlen P, Rottapel R, Gibert B, Correa RJM, Shepherd TG, Dick FA. Elife. 2024 Jul 18;12:RP91766. doi: 10.7554/eLife.91766. PubMed |
| Notch signaling suppresses neuroendocrine differentiation and alters the immune microenvironment in advanced prostate cancer. Ku SY, Wang Y, Garcia MM, Yamada Y, Mizuno K, Long MD, Rosario S, Chinnam M, Al Assaad M, Puca L, Kim MJ, Bakht MK, Venkadakrishnan VB, Robinson BD, Acosta AM, Wadosky KM, Mosquera JM, Goodrich DW, Beltran H. J Clin Invest. 2024 Jul 18;134(17):e175217. doi: 10.1172/JCI175217. PubMed |
| The splicing factor CCAR1 regulates the Fanconi anemia/BRCA pathway. Harada N, Asada S, Jiang L, Nguyen H, Moreau L, Marina RJ, Adelman K, Iyer DR, D'Andrea AD. Mol Cell. 2024 Jul 25;84(14):2618-2633.e10. doi: 10.1016/j.molcel.2024.06.031. Epub 2024 Jul 17. PubMed |
| The actin binding protein profilin 1 localizes inside mitochondria and is critical for their function. Read TA, Cisterna BA, Skruber K, Ahmadieh S, Liu TM, Vitriol JA, Shi Y, Black JB, Butler MT, Lindamood HL, Lefebvre AE, Cherezova A, Ilatovskaya DV, Bear JE, Weintraub NL, Vitriol EA. EMBO Rep. 2024 Aug;25(8):3240-3262. doi: 10.1038/s44319-024-00209-3. Epub 2024 Jul 18. PubMed |
| Dual inhibition of ATR and DNA-PKcs radiosensitizes ATM-mutant prostate cancer. Hofstad M, Woods A, Parra K, Sychev ZE, Mazzagatti A, Yu L, Gilbreath C, Ly P, Drake JM, Kittler R. bioRxiv [Preprint]. 2024 Jul 12:2024.07.10.602941. doi: 10.1101/2024.07.10.602941. PubMed |
| R-loop resolution by ARIP4 helicase promotes androgen-mediated transcription induction. Ng RR, Lin Z, Zhang Y, Ti SC, Javed A, Wong JWH, Fang Q, Leung JWC, Tang AHN, Huen MSY. Sci Adv. 2024 Jul 19;10(29):eadm9577. doi: 10.1126/sciadv.adm9577. Epub 2024 Jul 19. PubMed |
| Targeting conserved TIM3(+)VISTA(+) tumor-associated macrophages overcomes resistance to cancer immunotherapy. Vanmeerbeek I, Naulaerts S, Sprooten J, Laureano RS, Govaerts J, Trotta R, Pretto S, Zhao S, Cafarello ST, Verelst J, Jacquemyn M, Pociupany M, Boon L, Schlenner SM, Tejpar S, Daelemans D, Mazzone M, Garg AD. Sci Adv. 2024 Jul 19;10(29):eadm8660. doi: 10.1126/sciadv.adm8660. Epub 2024 Jul 19. PubMed |
| STAT3 in acute myeloid leukemia facilitates natural killer cell-mediated surveillance. Witalisz-Siepracka A, Denk CM, Zdarsky B, Hofmann L, Edtmayer S, Harm T, Weiss S, Heindl K, Hessenberger M, Summer S, Dutta S, Casanova E, Obermair GJ, Gyorffy B, Putz EM, Sill H, Stoiber D. Front Immunol. 2024 Jul 5;15:1374068. doi: 10.3389/fimmu.2024.1374068. eCollection 2024. PubMed |
| Cellular turnover and degradation of the most common missense cystathionine beta-synthase variants causing homocystinuria. Mijatovic E, Ascencao K, Szabo C, Majtan T. Protein Sci. 2024 Aug;33(8):e5123. doi: 10.1002/pro.5123. PubMed |
| LACTB suppresses liver cancer progression through regulation of ferroptosis. Zeng K, Huang N, Liu N, Deng X, Mu Y, Zhang X, Zhang J, Zhang C, Li Y, Li Z. Redox Biol. 2024 Sep;75:103270. doi: 10.1016/j.redox.2024.103270. Epub 2024 Jul 18. PubMed |
| BCL-2 and BOK regulate apoptosis by interaction of their C-terminal transmembrane domains. Beigl TB, Paul A, Fellmeth TP, Nguyen D, Barber L, Weller S, Schafer B, Gillissen BF, Aulitzky WE, Kopp HG, Rehm M, Andrews DW, Pluhackova K, Essmann F. EMBO Rep. 2024 Sep;25(9):3896-3924. doi: 10.1038/s44319-024-00206-6. Epub 2024 Jul 24. PubMed |
| VHL loss enhances antitumor immunity by activating the anti-viral DNA-sensing pathway. Jiao M, Hu M, Pan D, Liu X, Bao X, Kim J, Li F, Li CY. iScience. 2024 Jun 15;27(7):110285. doi: 10.1016/j.isci.2024.110285. eCollection 2024 Jul 19. PubMed |
| Metastatic breast cancer cells are metabolically reprogrammed to maintain redox homeostasis during metastasis. Biondini M, Lehuede C, Tabaries S, Annis MG, Pacis A, Ma EH, Tam C, Hsu BE, Audet-Delage Y, Abu-Thuraia A, Girondel C, Sabourin V, Totten SP, de Sa Tavares Russo M, Bridon G, Avizonis D, Guiot MC, St-Pierre J, Ursini-Siegel J, Jones R, Siegel PM. Redox Biol. 2024 Sep;75:103276. doi: 10.1016/j.redox.2024.103276. Epub 2024 Jul 20. PubMed |
| LINC00894 Regulates Cerebral Ischemia/Reperfusion Injury by Stabilizing EIF5 and Facilitating ATF4-Mediated Induction of FGF21 and ACOD1 Expression. Chen Y, Cui H, Han Z, Xu L, Wang L, Zhang Y, Liu L. Neurochem Res. 2024 Oct;49(10):2910-2925. doi: 10.1007/s11064-024-04213-w. Epub 2024 Jul 26. PubMed |
| Artesunate induces melanoma cell ferroptosis and augments antitumor immunity through targeting Ido1. Liu W, Zhou H, Lai W, Hu C, Wang Q, Yuan C, Luo C, Yang M, Hu M, Zhang R, Li G. Cell Commun Signal. 2024 Jul 26;22(1):378. doi: 10.1186/s12964-024-01759-8. PubMed |
| ASCT2 is a major contributor to serine uptake in cancer cells. Conger KO, Chidley C, Ozgurses ME, Zhao H, Kim Y, Semina SE, Burns P, Rawat V, Lietuvninkas L, Sheldon R, Ben-Sahra I, Frasor J, Sorger PK, DeNicola GM, Coloff JL. Cell Rep. 2024 Aug 27;43(8):114552. doi: 10.1016/j.celrep.2024.114552. Epub 2024 Jul 27. PubMed |
| HDAC8 Enhances the Function of HIF-2alpha by Deacetylating ETS1 to Decrease the Sensitivity of TKIs in ccRCC. Qian K, Li W, Ren S, Peng W, Qing B, Liu X, Wei X, Zhu L, Wang Y, Jin X. Adv Sci (Weinh). 2024 Sep;11(36):e2401142. doi: 10.1002/advs.202401142. Epub 2024 Jul 29. PubMed |
| Cyclophilin J limits linear ubiquitin signaling and controls colorectal cancer progression. Sheng C, Yao C, Wang J, Mao Y, Fu L, Chen S. J Biol Chem. 2024 Sep;300(9):107610. doi: 10.1016/j.jbc.2024.107610. Epub 2024 Jul 27. PubMed |
| Sub-genomic flaviviral RNA elements increase the stability and abundance of recombinant AAV vector transcripts. Meganck RM, Ogurlu R, Liu J, Moller-Tank S, Tse V, Blondel LO, Rosales A, Hall AC, Vincent HA, Moorman NJ, Marzluff WF, Asokan A. J Virol. 2024 Aug 20;98(8):e0009524. doi: 10.1128/jvi.00095-24. Epub 2024 Jul 31. PubMed |
| Targeting Catechol-O-Methyltransferase Induces Mitochondrial Dysfunction and Enhances the Efficacy of Radiotherapy in Glioma. Jiao M, Pirozzi CJ, Yu C, Bao X, Hu M, Pan D, Littleton S, Reynolds N, Saban DR, Li F, Li CY. Cancer Res. 2024 Nov 4;84(21):3640-3656. doi: 10.1158/0008-5472.CAN-24-0134. PubMed |
| A platform to deliver single and bi-specific Cas9/guide RNA to perturb genes in vitro and in vivo. Li YJ, Chien SH, Huang R, Herrmann A, Zhao Q, Li PC, Zhang C, Martincuks A, Santiago NL, Zong K, Swiderski P, Okimoto RA, Song M, Rodriguez L, Forman SJ, Wang X, Yu H. Mol Ther. 2024 Oct 2;32(10):3629-3649. doi: 10.1016/j.ymthe.2024.07.025. Epub 2024 Jul 31. PubMed |
| UNC13B regulates the sensitivity of Wilms' tumor cells to doxorubicin by modulating lysosomes. Chen X, Bao Y, Sun G, Wang X, Zhu J. Oncol Lett. 2024 Jul 22;28(3):446. doi: 10.3892/ol.2024.14579. eCollection 2024 Sep. PubMed |
| Spindle assembly checkpoint-dependent mitotic delay is required for cell division in absence of centrosomes. Farrell KC, Wang JT, Stearns T. Elife. 2024 Aug 2;12:RP84875. doi: 10.7554/eLife.84875. PubMed |
| Genome-wide CRISPR screening identifies tyrosylprotein sulfotransferase-2 as a target for augmenting anti-PD1 efficacy. Oh Y, Kim S, Kim Y, Kim H, Jang D, Shin S, Lee SJ, Kim J, Lee SE, Oh J, Yang Y, Kim D, Jung HR, Kim S, Kim J, Min K, Cho B, Seo H, Han D, Park H, Cho SY. Mol Cancer. 2024 Aug 2;23(1):155. doi: 10.1186/s12943-024-02068-x. PubMed |
| ANGPTL4 Suppresses Clear Cell Renal Cell Carcinoma via Inhibition of Lysosomal Acid Lipase. Jin Z, De U, Tithi TI, Kleberg J, Nataraj A, Jolley E, Carelock ME, Davies BS, Zhang W, Kolb R. Cancer Res Commun. 2024 Aug 1;4(8):2242-2254. doi: 10.1158/2767-9764.CRC-24-0016. PubMed |
| The expression of PD-L1 on tumor-derived exosomes enhances infiltration and anti-tumor activity of alphaCD3 x alphaPD-L1 bispecific antibody-armed T cells. Cho J, Tae N, Song Y, Kim CW, Lee SJ, Ahn JH, Lee KH, Lee BH, Kim BS, Chang SY, Kim DH, Ko HJ. Cancer Immunol Immunother. 2024 Aug 6;73(10):196. doi: 10.1007/s00262-024-03785-4. PubMed |
| Development of a highly sensitive platform for protein-protein interaction detection and regulation of T cell function. Hayashi H, Mak TW, Tanaka Y, Kubo Y, Izumida M, Urae R, Matsuyama T. Proc Natl Acad Sci U S A. 2024 Aug 13;121(33):e2318190121. doi: 10.1073/pnas.2318190121. Epub 2024 Aug 6. PubMed |
| A cellular reporter system to evaluate endogenous fetal hemoglobin induction and screen for therapeutic compounds. Verheul TCJ, Gillemans N, Putzker K, Majied R, Li T, Vasiliou M, Eussen B, de Klein A, van IJcken WFJ, van den Akker E, von Lindern M, Lewis J, Uhrig U, Nakamura Y, van Dijk T, Philipsen S. Hemasphere. 2024 Aug 6;8(8):e139. doi: 10.1002/hem3.139. eCollection 2024 Aug. PubMed |
| Epitranscriptomic m(5)C methylation of SARS-CoV-2 RNA regulates viral replication and the virulence of progeny viruses in the new infection. Wang H, Feng J, Fu Z, Xu T, Liu J, Yang S, Li Y, Deng J, Zhang Y, Guo M, Wang X, Zhang Z, Huang Z, Lan K, Zhou L, Chen Y. Sci Adv. 2024 Aug 9;10(32):eadn9519. doi: 10.1126/sciadv.adn9519. Epub 2024 Aug 7. PubMed |
| SYNGAP1 deficiency disrupts synaptic neoteny in xenotransplanted human cortical neurons in vivo. Vermaercke B, Iwata R, Wierda K, Boubakar L, Rodriguez P, Ditkowska M, Bonin V, Vanderhaeghen P. Neuron. 2024 Sep 25;112(18):3058-3068.e8. doi: 10.1016/j.neuron.2024.07.007. Epub 2024 Aug 6. PubMed |
| RNA helicase SKIV2L limits antiviral defense and autoinflammation elicited by the OAS-RNase L pathway. Yang K, Dong B, Asthana A, Silverman RH, Yan N. EMBO J. 2024 Sep;43(18):3876-3894. doi: 10.1038/s44318-024-00187-1. Epub 2024 Aug 7. PubMed |
| Oxysterole-binding protein targeted by SARS-CoV-2 viral proteins regulates coronavirus replication. Ma-Lauer Y, Li P, Niemeyer D, Richter A, Pusl K, von Brunn B, Ru Y, Xiang C, Schwinghammer S, Liu J, Baral P, Berthold EJ, Qiu H, Roy A, Kremmer E, Flaswinkel H, Drosten C, Jin Z, von Brunn A. Front Cell Infect Microbiol. 2024 Jul 25;14:1383917. doi: 10.3389/fcimb.2024.1383917. eCollection 2024. PubMed |
| PD-L1 deglycosylation promotes its nuclear translocation and accelerates DNA double-strand-break repair in cancer. Shu Z, Dwivedi B, Switchenko JM, Yu DS, Deng X. Nat Commun. 2024 Aug 9;15(1):6830. doi: 10.1038/s41467-024-51242-8. PubMed |
| Differential utilization of vitamin B(12)-dependent and independent pathways for propionate metabolism across human cells. Gouda H, Ji Y, Rath S, Watkins D, Rosenblatt D, Mootha V, Jones JW, Banerjee R. J Biol Chem. 2024 Sep;300(9):107662. doi: 10.1016/j.jbc.2024.107662. Epub 2024 Aug 14. PubMed |
| CA19-9-Positive Extracellular Vesicle Is a Risk Factor for Cancer-Associated Thrombosis in Pancreatic Cancer. Shibata C, Otsuka M, Ishigaki K, Seimiya T, Kishikawa T, Fujishiro M. Gastro Hep Adv. 2024 Feb 29;3(4):551-561. doi: 10.1016/j.gastha.2024.02.005. eCollection 2024. PubMed |
| Integrative plasma and fecal metabolomics identify functional metabolites in adenoma-colorectal cancer progression and as early diagnostic biomarkers. Sun Y, Zhang X, Hang D, Lau HC, Du J, Liu C, Xie M, Pan Y, Wang L, Liang C, Zhou X, Chen D, Rong J, Zhao Z, Cheung AH, Wu Y, Gou H, Wong CC, Du L, Deng J, Hu Z, Shen H, Miao Y, Yu J. Cancer Cell. 2024 Aug 12;42(8):1386-1400.e8. doi: 10.1016/j.ccell.2024.07.005. PubMed |
Circadian period is compensated for repressor protein turnover rates in single cells.
Gabriel CH, Del Olmo M, Rizki Widini A, Roshanbin R, Woyde J, Hamza E, Gutu NN, Zehtabian A, Ewers H, Granada A, Herzel H, Kramer A.
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PubMed
Associated Plasmids |
| Primate-specific BTN3A2 protects against SARS-CoV-2 infection by interacting with and reducing ACE2. Xu L, Yu D, Xu M, Liu Y, Yang LX, Zou QC, Feng XL, Li MH, Sheng N, Yao YG. EBioMedicine. 2024 Sep;107:105281. doi: 10.1016/j.ebiom.2024.105281. Epub 2024 Aug 13. PubMed |
| OPA1 promotes ferroptosis by augmenting mitochondrial ROS and suppressing an integrated stress response. Liang FG, Zandkarimi F, Lee J, Axelrod JL, Pekson R, Yoon Y, Stockwell BR, Kitsis RN. Mol Cell. 2024 Aug 22;84(16):3098-3114.e6. doi: 10.1016/j.molcel.2024.07.020. Epub 2024 Aug 13. PubMed |
| RPL22 is a tumor suppressor in MSI-high cancers and a splicing regulator of MDM4. Weinstein HNW, Hu K, Fish L, Chen YA, Allegakoen P, Pham JH, Hui KSF, Chang CH, Tutar M, Benitez-Rivera L, Baco MB, Song H, Giacomelli AO, Vazquez F, Ghandi M, Goodarzi H, Huang FW. Cell Rep. 2024 Aug 27;43(8):114622. doi: 10.1016/j.celrep.2024.114622. Epub 2024 Aug 14. PubMed |
| TBK1 and IKKepsilon protect target cells from IFNgamma-mediated T cell killing via an inflammatory apoptotic mechanism. Sun ND, Carr AR, Krogman EN, Chawla Y, Zhong J, Guttormson MC, Chan M, Hsu MA, Dong H, Bogunovic D, Pandey A, Rogers LM, Ting AT. bioRxiv [Preprint]. 2024 Aug 8:2024.08.06.606693. doi: 10.1101/2024.08.06.606693. PubMed |
| TFE3 fusions direct an oncogenic transcriptional program that drives OXPHOS and unveils vulnerabilities in translocation renal cell carcinoma. Li J, Huang K, McBride F, Sadagopan A, Gallant DS, Thakur M, Khanna P, Li B, Ge M, Weiss CN, Achom M, Xu Q, Huang K, Ryback BA, Gui M, Bar-Peled L, Viswanathan SR. bioRxiv [Preprint]. 2024 Aug 10:2024.08.09.607311. doi: 10.1101/2024.08.09.607311. PubMed |
| Translation efficiency covariation across cell types is a conserved organizing principle of mammalian transcriptomes. Liu Y, Rao S, Hoskins I, Geng M, Zhao Q, Chacko J, Ghatpande V, Qi K, Persyn L, Wang J, Zheng D, Zhong Y, Park D, Cenik ES, Agarwal V, Ozadam H, Cenik C. bioRxiv [Preprint]. 2025 Jan 18:2024.08.11.607360. doi: 10.1101/2024.08.11.607360. PubMed |
| Valproic acid targets IDH1 mutants through alteration of lipid metabolism. Elahi LS, Condro MC, Kawaguchi R, Qin Y, Alvarado AG, Gruender B, Qi H, Li T, Lai A, Castro MG, Lowenstein PR, Garrett MC, Kornblum HI. NPJ Metab Health Dis. 2024;2(1):20. doi: 10.1038/s44324-024-00021-6. Epub 2024 Aug 13. PubMed |
| Genome-wide CRISPR screening identifies critical role of phosphatase and tensin homologous (PTEN) in sensitivity of acute myeloid leukemia to chemotherapy. Lin L, Tao J, Meng Y, Gan Y, He X, Li S, Zhang J, Gao F, Xin D, Wang L, Fan Y, Chen B, Lu Z, Xu Y. J Zhejiang Univ Sci B. 2024 Aug 15;25(8):700-710. doi: 10.1631/jzus.B2300555. PubMed |
| The deubiquitinating enzyme USP35 regulates the stability of NRF2 protein. Zhang D, Li J, Zhang C, Xue J, Li P, Shang K, Zhang X, Lang B. Open Life Sci. 2024 Aug 16;19(1):20220935. doi: 10.1515/biol-2022-0935. eCollection 2024. PubMed |
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| Mechanisms of KRAS inhibitor resistance in KRAS-mutant colorectal cancer harboring Her2 amplification and aberrant KRAS localization. Maruyama K, Shimizu Y, Nomura Y, Oh-Hara T, Takahashi Y, Nagayama S, Fujita N, Katayama R. NPJ Precis Oncol. 2025 Jan 6;9(1):4. doi: 10.1038/s41698-024-00793-6. PubMed |
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| Host cell lectins ASGR1 and DC-SIGN jointly with TMEM106B confer ACE2 independence and imdevimab resistance to SARS-CoV-2 pseudovirus with spike mutation E484D. Arora P, Zhang L, Nehlmeier I, Kempf A, Graichen L, Kreitz E, Sidarovich A, Rocha C, Gartner S, Winkler M, Schulz S, Jack H-M, Hoffmann M, Pohlmann S. J Virol. 2025 Feb 25;99(2):e0123024. doi: 10.1128/jvi.01230-24. Epub 2025 Jan 10. PubMed |
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| Microtubule acetylation is not required for HIV-1 infection or TRIM69-mediated restriction of HIV-1 infection. Lichon DM, LoMascolo NJ, Mounce BC, Campbell EM. J Virol. 2025 Feb 25;99(2):e0102624. doi: 10.1128/jvi.01026-24. Epub 2025 Jan 13. PubMed |
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| Rh-relaxin-2 attenuates oxidative stress and neuronal apoptosis via ERK-nNOS-NO pathway after germinal matrix hemorrhage in rats. Liu J, Cai Y, Rahman KU, Zhou Q, Liu G, Kang H, Li M, Zhang S, Wang G, Feng W, Zhang X, Zhang G, Song Y, Li P. Fluids Barriers CNS. 2025 Jan 15;22(1):8. doi: 10.1186/s12987-024-00616-7. PubMed |
| An epigenetic pathway regulates MHC-II expression and function in B cell lymphoma models. Zhang T, Beytullahoglu O, Tulaiha R, Luvisotto A, Szczepanski A, Tsuboyama N, Zhao Z, Wang L. J Clin Invest. 2025 Jan 16;135(2):e179703. doi: 10.1172/JCI179703. PubMed |
| Inactivation of glutathione S-transferase alpha 4 blocks Enterococcus faecalis-induced bystander effect by promoting macrophage ferroptosis. Ju Y, Ma C, Huang L, Tao Y, Li T, Li H, Huycke MM, Yang Y, Wang X. Gut Microbes. 2025 Dec;17(1):2451090. doi: 10.1080/19490976.2025.2451090. Epub 2025 Jan 16. PubMed |
| KSHV hijacks the antiviral kinase IKKepsilon to initiate lytic replication. Wang X, Liu Z, Xu X, Wang X, Ming Z, Liu C, Gao H, Li T, Liang Q. PLoS Pathog. 2025 Jan 17;21(1):e1012856. doi: 10.1371/journal.ppat.1012856. eCollection 2025 Jan. PubMed |
| The RING Finger E3 Ligase RNF25 Protects DNA Replication Forks Independently of its Canonical Roles in Ubiquitin Signaling. Chiou LF, Jayaprakash D, Droby GN, Zhang X, Yang Y, Mills CA, Webb TS, Barker NK, Wu D, Herring LE, Bowser J, Vaziri C. bioRxiv [Preprint]. 2025 Jan 9:2025.01.09.632184. doi: 10.1101/2025.01.09.632184. PubMed |
| Invasion of pancreatic ductal epithelial cells by Enterococcus faecalis is mediated by fibronectin and enterococcal fibronectin-binding protein A. Shimosaka M, Kondo J, Sonoda M, Kawaguchi R, Noda E, Nishikori K, Ogata A, Takamatsu S, Sasai K, Akita H, Eguchi H, Kamada Y, Okamoto S, Miyoshi E. Sci Rep. 2025 Jan 20;15(1):2585. doi: 10.1038/s41598-025-86531-9. PubMed |
| Targeting aldolase A in hepatocellular carcinoma leads to imbalanced glycolysis and energy stress due to uncontrolled FBP accumulation. Snaebjornsson MT, Poeller P, Komkova D, Rohrig F, Schlicker L, Winkelkotte AM, Chaves-Filho AB, Al-Shami KM, Caballero CD, Koltsaki I, Vogel FCE, Frias-Soler RC, Rudalska R, Schwarz JD, Wolf E, Dauch D, Steuer R, Schulze A. Nat Metab. 2025 Feb;7(2):348-366. doi: 10.1038/s42255-024-01201-w. Epub 2025 Jan 20. PubMed |
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| In vivo CRISPR-Cas9 genome editing in mice identifies genetic modifiers of somatic CAG repeat instability in Huntington's disease. Mouro Pinto R, Murtha R, Azevedo A, Douglas C, Kovalenko M, Ulloa J, Crescenti S, Burch Z, Oliver E, Kesavan M, Shibata S, Vitalo A, Mota-Silva E, Riggs MJ, Correia K, Elezi E, Demelo B, Carroll JB, Gillis T, Gusella JF, MacDonald ME, Wheeler VC. Nat Genet. 2025 Feb;57(2):314-322. doi: 10.1038/s41588-024-02054-5. Epub 2025 Jan 22. PubMed |
| ROR1 CAR-T cells and ferroptosis inducers orchestrate tumor ferroptosis via PC-PUFA2. Li D, Zhang W, Wang R, Xie S, Wang Y, Guo W, Huang Z, Lu C, Shan L, Liu H, Ma L, Hou X, Xu Z, Wang J. Biomark Res. 2025 Jan 23;13(1):17. doi: 10.1186/s40364-025-00730-0. PubMed |
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| SLC25A38 is required for mitochondrial pyridoxal 5'-phosphate (PLP) accumulation. Pena IA, Shi JS, Chang SM, Yang J, Block S, Adelmann CH, Keys HR, Ge P, Bathla S, Witham IH, Sienski G, Nairn AC, Sabatini DM, Lewis CA, Kory N, Vander Heiden MG, Heiman M. Nat Commun. 2025 Jan 24;16(1):978. doi: 10.1038/s41467-025-56130-3. PubMed |
Cell-free assays reveal that the HIV-1 capsid protects reverse transcripts from cGAS immune sensing.
Scott TM, Arnold LM, Powers JA, McCann DA, Rowe AB, Christensen DE, Pereira MJ, Zhou W, Torrez RM, Iwasa JH, Kranzusch PJ, Sundquist WI, Johnson JS.
PLoS Pathog. 2025 Jan 28;21(1):e1012206. doi: 10.1371/journal.ppat.1012206.
PubMed
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| PEBP1 amplifies mitochondrial dysfunction-induced integrated stress response. Cheng L, Meliala I, Kong Y, Chen J, Proud CG, Bjorklund M. Elife. 2025 Jan 29;13:RP102852. doi: 10.7554/eLife.102852. PubMed |
| Targeting pancreatic cancer glutamine dependency confers vulnerability to GPX4-dependent ferroptosis. Shen X, Chen Y, Tang Y, Lu P, Liu M, Mao T, Weng Y, Yu F, Liu Y, Tang Y, Wang L, Niu N, Xue J. Cell Rep Med. 2025 Feb 18;6(2):101928. doi: 10.1016/j.xcrm.2025.101928. Epub 2025 Jan 28. PubMed |
| Bat genomes illuminate adaptations to viral tolerance and disease resistance. Morales AE, Dong Y, Brown T, Baid K, Kontopoulos D-, Gonzalez V, Huang Z, Ahmed AW, Bhuinya A, Hilgers L, Winkler S, Hughes G, Li X, Lu P, Yang Y, Kirilenko BM, Devanna P, Lama TM, Nissan Y, Pippel M, Davalos LM, Vernes SC, Puechmaille SJ, Rossiter SJ, Yovel Y, Prescott JB, Kurth A, Ray DA, Lim BK, Myers E, Teeling EC, Banerjee A, Irving AT, Hiller M. Nature. 2025 Feb;638(8050):449-458. doi: 10.1038/s41586-024-08471-0. Epub 2025 Jan 29. PubMed |
| Targeting ABCD1-ACOX1-MET/IGF1R axis suppresses multiple myeloma. Han Z, Yan Z, Ma Z, Wang Y, Beus M, Lu J, Weidenhammer LB, Lakhani K, Lee J, Civils JD, Furdui CM, Liu L, Wu J, Kang Y, Bieberich E, Boise LH, Nikiforov MA. Leukemia. 2025 Mar;39(3):720-733. doi: 10.1038/s41375-025-02522-9. Epub 2025 Jan 30. PubMed |
| FBXO31-mediated ubiquitination of OGT maintains O-GlcNAcylation homeostasis to restrain endometrial malignancy. Zhang N, Meng Y, Mao S, Ni H, Huang C, Shen L, Fu K, Lv L, Yu C, Meekrathok P, Kuang C, Chen F, Zhang Y, Yuan K. Nat Commun. 2025 Feb 2;16(1):1274. doi: 10.1038/s41467-025-56633-z. PubMed |
| The O-glycosyltransferase C1GALT1 promotes EWSR1::FLI1 expression and is a therapeutic target for Ewing sarcoma. Banday S, Mishra AK, Rashid R, Ye T, Ali A, Li J, Yustein JT, Kelliher MA, Zhu LJ, Deibler SK, Malonia SK, Green MR. Nat Commun. 2025 Feb 2;16(1):1267. doi: 10.1038/s41467-025-56632-0. PubMed |
| Identification of selective SWI/SNF dependencies in enzalutamide-resistant prostate cancer. Gokbayrak B, Altintas UB, Lingadahalli S, Morova T, Huang CF, Ersoy Fazlioglu B, Pak Lok Yu I, Kalkan BM, Cejas P, Kung SHY, Fazli L, Kawamura A, Long HW, Acilan C, Onder TT, Bagci-Onder T, Lynch JT, Lack NA. Commun Biol. 2025 Feb 4;8(1):169. doi: 10.1038/s42003-024-07413-w. PubMed |
| Tetraspanin CD9 alters cellular trafficking and endocytosis of tetraspanin CD63, affecting CD63 packaging into small extracellular vesicles. Duke LC, Cone AS, Sun L, Dittmer DP, Meckes DG Jr, Tomko RJ Jr. J Biol Chem. 2025 Mar;301(3):108255. doi: 10.1016/j.jbc.2025.108255. Epub 2025 Feb 3. PubMed |
| Brd7 loss reawakens dormant metastasis initiating cells in lung by forging an immunosuppressive niche. Mondal J, Zhang J, Qing F, Li S, Kumar D, Huse JT, Giancotti FG. Nat Commun. 2025 Feb 5;16(1):1378. doi: 10.1038/s41467-025-56347-2. PubMed |
| Host 3' flap endonuclease Mus81 plays a critical role in trimming the terminal redundancy of hepatitis B virus relaxed circular DNA during covalently closed circular DNA formation. Zhang H, Long Q, Liu Y, Marchetti AL, Liu CD, Sun N, Guo H. PLoS Pathog. 2025 Feb 6;21(2):e1012918. doi: 10.1371/journal.ppat.1012918. eCollection 2025 Feb. PubMed |
| Genome-scale CRISPR/Cas9 screening reveals the role of PSMD4 in colibactin-mediated cell cycle arrest. Dougherty MW, Hoffmann RM, Hernandez MC, Airan Y, Gharaibeh RZ, Herzon SB, Yang Y, Jobin C. mSphere. 2025 Mar 25;10(3):e0069224. doi: 10.1128/msphere.00692-24. Epub 2025 Feb 7. PubMed |
| E6AP is essential for the proliferation of HPV-positive cancer cells by preventing senescence. Avenhaus A, Velimirovic M, Bulkescher J, Scheffner M, Hoppe-Seyler F, Hoppe-Seyler K. PLoS Pathog. 2025 Feb 7;21(2):e1012914. doi: 10.1371/journal.ppat.1012914. eCollection 2025 Feb. PubMed |
| Loss-of-function mutations in the dystonia gene THAP1 impair proteasome function by inhibiting PSMB5 expression. Ramage DE, Grant DW, Timms RT. Nat Commun. 2025 Feb 10;16(1):1511. doi: 10.1038/s41467-025-56782-1. PubMed |
| Mechanisms of NLRP3 activation and inhibition elucidated by functional analysis of disease-associated variants. Feng S, Wierzbowski MC, Hrovat-Schaale K, Dumortier A, Zhang Y, Zyulina M, Baker PJ, Reygaerts T, Steiner A, De Nardo D, Narayanan DL, Milhavet F, Pinzon-Charry A, Arostegui JI, Khubchandani RP, Geyer M, Boursier G, Masters SL. Nat Immunol. 2025 Mar;26(3):511-523. doi: 10.1038/s41590-025-02088-9. Epub 2025 Feb 10. PubMed |
| A CRISPR-Cas9 screen reveals genetic determinants of the cellular response to decitabine. Zhang P, Zhang Z, Wang Y, Du W, Song X, Lai W, Wang H, Zhu B, Xiong J. EMBO Rep. 2025 Mar;26(6):1528-1565. doi: 10.1038/s44319-025-00385-w. Epub 2025 Feb 10. PubMed |
| A guanidine-based coronavirus replication inhibitor which targets the nsp15 endoribonuclease and selects for interferon-susceptible mutant viruses. Van Loy B, Pujol E, Kamata K, Lee XY, Bakirtzoglou N, Van Berwaer R, Vandeput J, Mestdagh C, Persoons L, De Wijngaert B, Goovaerts Q, Noppen S, Jacquemyn M, Ahmadzadeh K, Bernaerts E, Martin-Lopez J, Escriche C, Vanmechelen B, Krasniqi B, Singh AK, Daelemans D, Maes P, Matthys P, Dehaen W, Rozenski J, Das K, Voet A, Vazquez S, Naesens L, Stevaert A. PLoS Pathog. 2025 Feb 11;21(2):e1012571. doi: 10.1371/journal.ppat.1012571. eCollection 2025 Feb. PubMed |
Genomic mediators of acquired resistance to immunotherapy in metastatic melanoma.
Schiantarelli J, Benamar M, Park J, Sax HE, Oliveira G, Bosma-Moody A, Campbell KM, Liu D, Johnson DB, Rodig S, Wu CJ, Hodi FS, Ribas A, Van Allen E, Haq R.
Cancer Cell. 2025 Feb 10;43(2):308-316.e6. doi: 10.1016/j.ccell.2025.01.009.
PubMed
Associated Plasmids |
| Multi-omics analysis reveals the impact of YAP/TEAD4-mediated EIF5A1 expression on mitochondrial apoptosis and bladder cancer progression. Li KP, Wan S, Wang CY, Chen SY, Wang L, Liu SH, Yang L. BMC Cancer. 2025 Feb 11;25(1):234. doi: 10.1186/s12885-025-13522-4. PubMed |
| Aberrant expression of GTPase-activating protein ARAP1 triggers circular dorsal ruffles associated with malignancy in hepatocellular carcinoma Hep3B cells. Sun X, Li Y, He Y, Cheng L, Wang L, Wei J, Chen J, Du L, Shen Z, Xie Y, Midgley AC, Jiang W, Yoshida S. Cell Commun Signal. 2025 Feb 11;23(1):75. doi: 10.1186/s12964-025-02084-4. PubMed |
| Interleukin-1 prevents SARS-CoV-2-induced membrane fusion to restrict viral transmission via induction of actin bundles. Zheng X, Yu S, Zhou Y, Yu K, Gao Y, Chen M, Duan D, Li Y, Cui X, Mou J, Yang Y, Wang X, Chen M, Jiu Y, Zhao J, Meng G. Elife. 2025 Feb 12;13:RP98593. doi: 10.7554/eLife.98593. PubMed |
| UM171 glues asymmetric CRL3-HDAC1/2 assembly to degrade CoREST corepressors. Yeo MJR, Zhang O, Xie X, Nam E, Payne NC, Gosavi PM, Kwok HS, Iram I, Lee C, Li J, Chen NJ, Nguyen K, Jiang H, Wang ZA, Lee K, Mao H, Harry SA, Barakat IA, Takahashi M, Waterbury AL, Barone M, Mattevi A, Carr SA, Udeshi ND, Bar-Peled L, Cole PA, Mazitschek R, Liau BB, Zheng N. Nature. 2025 Mar;639(8053):232-240. doi: 10.1038/s41586-024-08532-4. Epub 2025 Feb 12. PubMed |
| STT3B promotes porcine epidemic diarrhea virus replication by regulating N-glycosylation of PEDV S protein. Zhu H, Lou J, Yang Z, Bai J, Jiang P, Wang X, Liu X. J Virol. 2025 Mar 18;99(3):e0001825. doi: 10.1128/jvi.00018-25. Epub 2025 Feb 13. PubMed |
| Targeting ELOVL6 to disrupt c-MYC driven lipid metabolism in pancreatic cancer enhances chemosensitivity. Garcia Garcia A, Ferrer Aporta M, Vallejo Palma G, Giraldez Trujillo A, Castillo-Gonzalez R, Calzon Lozano D, Mora Perdiguero A, Munoz Velasco R, Colina Castro M, de Simone Benito E, Torres-Ruiz R, Rodriguez-Perales S, Dehairs J, Swinnen JV, Garcia-Canaveras JC, Lahoz A, Montalvo Quiros S, Del Pozo-Rojas C, Luque Rioja C, Monroy F, Herraez-Aguilar D, Alonso Riano M, Rodriguez Peralto JL, Sanchez-Arevalo Lobo VJ. Nat Commun. 2025 Feb 16;16(1):1694. doi: 10.1038/s41467-025-56894-8. PubMed |
Non-AUG HIV-1 uORF translation elicits specific T cell immune response and regulates viral transcript expression.
Labaronne E, Decimo D, Bertrand L, Guiguettaz L, Sohier TJM, Cluet D, Vivet-Boudou V, Chaves Valadao AL, Dahoui C, Francois P, Hatin I, Lambotte O, Samri A, Autran B, Etienne L, Goujon C, Paillart JC, Namy O, Ramirez BC, Ohlmann T, Moris A, Ricci EP.
Nat Commun. 2025 Feb 18;16(1):1706. doi: 10.1038/s41467-025-56772-3.
PubMed
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| Lamin B1 regulates RNA splicing factor expression by modulating the spatial positioning and chromatin interactions of the ETS1 gene locus. Shin GS, Jo AR, Kim J, Kim JY, Kim CH, An MJ, Lee HM, Park Y, Hwangbo Y, Kim JW. Anim Cells Syst (Seoul). 2025 Feb 15;29(1):149-162. doi: 10.1080/19768354.2025.2465325. eCollection 2025. PubMed |
| PARP7 inhibits type I interferon signaling to prevent autoimmunity and lung disease. Jeltema D, Knox K, Dobbs N, Tang Z, Xing C, Araskiewicz A, Yang K, Siordia IR, Matthews J, Cohen M, Yan N. J Exp Med. 2025 May 5;222(5):e20241184. doi: 10.1084/jem.20241184. Epub 2025 Feb 19. PubMed |
| mTOR-mediated p62/SQSTM1 stabilization confers a robust survival mechanism for ovarian cancer. Tamura T, Nagai S, Masuda K, Imaeda K, Sugihara E, Yamasaki J, Kawaida M, Otsuki Y, Suina K, Nobusue H, Akahane T, Chiyoda T, Kisu I, Kobayashi Y, Banno K, Sakurada K, Okita H, Yamaguchi R, Ahmed AA, Yamagami W, Saya H, Aoki D, Nagano O. Cancer Lett. 2025 Apr 28;616:217565. doi: 10.1016/j.canlet.2025.217565. Epub 2025 Feb 17. PubMed |
| Multiplexed CRISPRi Reveals a Transcriptional Switch Between KLF Activators and Repressors in the Maturing Neocortex. Kirk RW, Sun L, Xiao R, Clark EA, Nelson S. bioRxiv [Preprint]. 2025 Feb 15:2025.02.07.636951. doi: 10.1101/2025.02.07.636951. PubMed |
| Target cell adhesion limits macrophage phagocytosis and promotes trogocytosis. Rollins K, Fiaz S, Morrissey M. bioRxiv [Preprint]. 2025 Feb 8:2025.02.06.636906. doi: 10.1101/2025.02.06.636906. PubMed |
| TRIP13 protects pancreatic cancer cells against intrinsic and therapy-induced DNA replication stress. Anand JR, Droby GN, Joseph S, Patel U, Zhang X, Klomp JA, Der CJ, Purvis JE, Wolff SC, Bowser J, Vaziri C. bioRxiv [Preprint]. 2025 Jan 27:2025.01.26.634889. doi: 10.1101/2025.01.26.634889. PubMed |
| Restraint of inflammasome-driven cytokine responses through the mRNA stability protein TTP. O'Keefe ME, Kondolf HC, De Santis S, Pizarro TT, Abbott DW. Cell Rep. 2025 Mar 25;44(3):115340. doi: 10.1016/j.celrep.2025.115340. Epub 2025 Feb 20. PubMed |
| Colorectal cancer hot spot mutations attenuate the ASXL-MLL4 interaction. Biswas S, Lee JE, Xie G, Masclef L, Ren Z, Cote J, Affar EB, Ge K, Kutateladze TG. J Biol Chem. 2025 Mar;301(3):108333. doi: 10.1016/j.jbc.2025.108333. Epub 2025 Feb 19. PubMed |
| Pluripotency factor Tex10 finetunes Wnt signaling for spermatogenesis and primordial germ cell development. Yuan F, Yang J, Ma F, Hu Z, Malik V, Zang R, Li D, Shi X, Huang X, Zhou H, Wang J. Nat Commun. 2025 Feb 23;16(1):1900. doi: 10.1038/s41467-025-57165-2. PubMed |
| CD47 prevents Rac-mediated phagocytosis through Vav1 dephosphorylation. Miller WD, Mishra AK, Sheedy CJ, Bond A, Gardner BM, Montell DJ, Morrissey MA. bioRxiv [Preprint]. 2025 Feb 12:2025.02.11.637707. doi: 10.1101/2025.02.11.637707. PubMed |
| The lncRNA DUBR is regulated by CTCF and coordinates chromatin landscape and gene expression in hematopoietic cells. Nunez-Martinez HN, Tapia-Urzua G, Cerecedo-Castillo AJ, Peralta-Alvarez CA, Guerrero G, Huarte M, Recillas-Targa F. Nucleic Acids Res. 2025 Feb 8;53(4):gkaf093. doi: 10.1093/nar/gkaf093. PubMed |
| FTO deficiency facilitates epithelia dysfunction in oral lichen planus. Fan Y, Hao Y, Ding Y, Wang X, Ge X. Mol Ther Nucleic Acids. 2025 Jan 25;36(1):102463. doi: 10.1016/j.omtn.2025.102463. eCollection 2025 Mar 11. PubMed |
| Single-cell delineation of strain-specific HIV-1 Vif activities using dual reporter sensor cells and live cell imaging. Guerrero JF, Zimdars LL, Bruce JW, Becker JT, Evans EL 3rd, Torabi S, Striker R, Berry SM, Sherer NM. J Virol. 2025 Mar 18;99(3):e0157924. doi: 10.1128/jvi.01579-24. Epub 2025 Feb 25. PubMed |
| RNF20 dual regulation of MDA5 signaling to maintain immune homeostasis in chickens. Wang J, Liu Q, Zhang K, Zhao S, Shao Q, Fu F, Ma J, Wang Z, Yan Y-x, Wang H, Sun J, Cheng Y. J Virol. 2025 Mar 18;99(3):e0200824. doi: 10.1128/jvi.02008-24. Epub 2025 Feb 25. PubMed |
| Regulation of CXCR4 function by S1P(1) through heteromerization. Kim HT, Jeong JY, Huh WK. Cell Commun Signal. 2025 Feb 26;23(1):111. doi: 10.1186/s12964-025-02099-x. PubMed |
| MicroRNA profiling identifies VHL/HIF-2alpha dependent miR-2355-5p as a key modulator of clear cell Renal cell carcinoma tumor growth. Page PM, Dastous SA, Richard PO, Pavic M, Nishimura T, Riazalhosseini Y, Crapoulet N, Martin M, Turcotte S. Cancer Cell Int. 2025 Feb 27;25(1):71. doi: 10.1186/s12935-025-03711-3. PubMed |
| HBV-associated hepatocellular carcinomas inhibit antitumor CD8(+) T cell via the long noncoding RNA HDAC2-AS2. Gao Y, Zhang Z, Huang X, You M, Du C, Li N, Hao Y, Wang K, Ding X, Yang F, Cheng SQ, Luo J, Chen R, Yang P. Nat Commun. 2025 Feb 28;16(1):2055. doi: 10.1038/s41467-025-57367-8. PubMed |
| Integrated computational analysis identifies therapeutic targets with dual action in cancer cells and T cells. Luo C, Zhang R, Guo R, Wu L, Xue T, He Y, Jin Y, Zhao Y, Zhang Z, Zhang P, Ye S, Li X, Li D, Zhang W, Wang C, Lai L, Pan-Hammarstrom Q, Wucherpfennig KW, Gao Z, Pan D, Zeng Z. Immunity. 2025 Mar 11;58(3):745-765.e9. doi: 10.1016/j.immuni.2025.02.007. Epub 2025 Feb 28. PubMed |
Requirements for nuclear GRP78 transcriptional regulatory activities and interaction with nuclear GRP94.
Liu Z, Ha DP, Lin LL, Qi L, Lee AS.
J Biol Chem. 2025 Feb 28;301(4):108369. doi: 10.1016/j.jbc.2025.108369.
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| Chenodeoxycholic acid modulates cholestatic niche through FXR/Myc/P-selectin axis in liver endothelial cells. Zhang P, Li X, Liang J, Zheng Y, Tong Y, Shen J, Chen Y, Han P, Chu S, Liu R, Zheng M, Zhai Y, Tang X, Zhang C, Qu H, Mi P, Chai J, Yuan D, Li S. Nat Commun. 2025 Mar 1;16(1):2093. doi: 10.1038/s41467-025-57351-2. PubMed |
| CHIP protects lysosomes from CLN4 mutant-induced membrane damages. Lee J, Zou J, Binti Mazli WNA, Chin N, Jarnik M, Saidi L, Xu Y, Replogle J, Ward M, Bonifacino J, Zheng W, Hao L, Ye Y. bioRxiv [Preprint]. 2025 Feb 19:2025.02.18.638932. doi: 10.1101/2025.02.18.638932. PubMed |
| Interplay between CTCF-binding and CTCF-lacking regulatory elements in generating an architectural stripe at the Igh locus. Ma F, Ollikainen N, Du H, Braikia FZ, Cui N, Bianchi AH, Dunn C, Nguyen C, Fan J, De S, Sen R, Qiu X. Nat Commun. 2025 Mar 3;16(1):2148. doi: 10.1038/s41467-025-57373-w. PubMed |
| Semaphorin 3F inhibits breast cancer metastasis by regulating the Akt-mTOR and TGFbeta signaling pathways via neuropilin-2. Nakayama H, Murakami A, Nishida-Fukuda H, Fukuda S, Matsugi E, Nakahara M, Kusumoto C, Kamei Y, Higashiyama S. Sci Rep. 2025 Mar 3;15(1):7394. doi: 10.1038/s41598-025-91559-y. PubMed |
| TMEM41B is an endoplasmic reticulum Ca(2+) release channel maintaining naive T cell quiescence and responsiveness. Ma Y, Wang Y, Zhao X, Jin G, Xu J, Li Z, Yin N, Gao Z, Xia B, Peng M. Cell Discov. 2025 Mar 4;11(1):18. doi: 10.1038/s41421-024-00766-w. PubMed |
| The TCF4 Gene Regulates Apoptosis of Corneal Endothelial Cells in Fuchs Endothelial Corneal Dystrophy. Nakagawa T, Honda T, Yuasa T, Nishiuchi G, Sato M, Tokunaga A, Nakahara M, Tourtas T, Schlotzer-Schrehardt U, Kruse F, Padmanabhan P, Chatterjee A, Sathe G, Ghose V, Janakiraman N, Blake DJ, Koizumi N, Elchuri S, Okumura N. Invest Ophthalmol Vis Sci. 2025 Mar 3;66(3):16. doi: 10.1167/iovs.66.3.16. PubMed |
| Succinate dehydrogenase activity supports de novo purine synthesis. Nengroo MA, Klein AT, Carr HS, Vidal-Cruchez O, Sahu U, McGrail DJ, Sahni N, Gao P, Asara JM, Shah H, Mendillo ML, Ben-Sahra I. bioRxiv [Preprint]. 2025 Mar 1:2025.02.26.640389. doi: 10.1101/2025.02.26.640389. PubMed |
| A positive feedback loop between SMAD3 and PINK1 in regulation of mitophagy. Tang M, Rong D, Gao X, Lu G, Tang H, Wang P, Shao NY, Xia D, Feng XH, He WF, Chen W, Lu JH, Liu W, Shen HM. Cell Discov. 2025 Mar 11;11(1):22. doi: 10.1038/s41421-025-00774-4. PubMed |
| NEMO is essential for directing the kinases IKKalpha and ATM to the sites of DNA damage. Alonso-Maranon J, Sole L, Alvarez-Villanueva D, Maqueda M, Lobo-Jarne T, Montoto A, Yelamos J, Borras E, Uraga L, Hooper C, Sabido E, Miyamoto S, Bigas A, Espinosa L. Sci Signal. 2025 Mar 11;18(877):eadr0128. doi: 10.1126/scisignal.adr0128. Epub 2025 Mar 11. PubMed |
| The Selective 3-MST Inhibitor I3MT-3 Works as a Potent Caspase-1 Inhibitor. Otani K, Komatsu R, Noguchi T, Suzuki W, Hirata Y, Matsuzawa A. Int J Mol Sci. 2025 Mar 2;26(5):2237. doi: 10.3390/ijms26052237. PubMed |
| A Truncated Mutation of TP53 Promotes Chemoresistance in Tongue Squamous Cell Carcinoma. Du X, Zheng J, Lu X, Zhang Y. Int J Mol Sci. 2025 Mar 6;26(5):2353. doi: 10.3390/ijms26052353. PubMed |
| Comprehensive genomic dependency landscape of a human colon cancer organoid. Khalili S, Mohseninia A, Liu C, Banister CE, Heine P, Khazan M, Morrison SE, Gokare P, Cowley GS, Weir BA, Pocalyko D, Bachman KE, Buckhaults PJ. Commun Biol. 2025 Mar 14;8(1):436. doi: 10.1038/s42003-025-07822-5. PubMed |
| Genome-wide screening in human embryonic stem cells identifies genes and pathways involved in the p53 pathway. Haddad A, Golan-Lev T, Benvenisty N, Goldberg M. Mol Med. 2025 Mar 13;31(1):97. doi: 10.1186/s10020-025-01141-5. PubMed |
| Enhanced therapeutic efficacy of anti-PD-1 blockade by targeting LAMP2A inhibits lysosomal degradation of STING and TBK1. Wang X, Zhang D, Xiao J, Wang L, Wang J, Cui X, Tan J, Liu Y, Miao S. Theranostics. 2025 Feb 18;15(7):3207-3222. doi: 10.7150/thno.103426. eCollection 2025. PubMed |
| Ectopic expression of testis-specific transcription elongation factor in driving cancer. Zheng B, Iwanaszko M, Soliman SHA, Ishi Y, Gold S, Qiu R, Howard BC, Das M, Zhao Z, Hashizume R, Wang L, Shilatifard A. Sci Adv. 2025 Mar 14;11(11):eads4200. doi: 10.1126/sciadv.ads4200. Epub 2025 Mar 14. PubMed |
| Metformin sensitizes triple-negative breast cancer to histone deacetylase inhibitors by targeting FGFR4. Gu Z, Ye F, Luo H, Li X, Gong Y, Mao S, Jia X, Han X, Han B, Fu Y, Cheng X, Li J, Shao Z, Wen P, Hu X, Zhuang Z. J Biomed Sci. 2025 Mar 17;32(1):36. doi: 10.1186/s12929-025-01129-7. PubMed |
| Therapeutic targeting de novo purine biosynthesis driven by beta-catenin-dependent PPAT upregulation in hepatoblastoma. Ding M, Ma C, Lin Y, Fang H, Xu Y, Wang S, Chen Y, Zhou J, Gao H, Shan Y, Yang L, Sun H, Tang Y, Wu X, Zhu L, Zheng L, Assaraf YG, Zhou BS, Gu S, Li H. Cell Death Dis. 2025 Mar 17;16(1):179. doi: 10.1038/s41419-025-07502-6. PubMed |
| MyoD1 localization at the nuclear periphery is mediated by association of WFS1 with active enhancers. Georgiou K, Sarigol F, Nimpf T, Knapp C, Filipczak D, Foisner R, Naetar N. Nat Commun. 2025 Mar 17;16(1):2614. doi: 10.1038/s41467-025-57758-x. PubMed |
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