pSpCas9(BB)-2A-GFP (PX458) Citations (1944)

Originally described in: Genome engineering using the CRISPR-Cas9 system.
Ran FA, Hsu PD, Wright J, Agarwala V, Scott DA, Zhang F Nat Protoc. 2013 Nov;8(11):2281-308. doi: 10.1038/nprot.2013.143. Epub 2013 Oct 24. PubMed Journal

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Articles Citing pSpCas9(BB)-2A-GFP (PX458)

Articles
Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5'-diphosphates. Goubau D, Schlee M, Deddouche S, Pruijssers AJ, Zillinger T, Goldeck M, Schuberth C, Van der Veen AG, Fujimura T, Rehwinkel J, Iskarpatyoti JA, Barchet W, Ludwig J, Dermody TS, Hartmann G, Reis e Sousa C. Nature. 2014 Oct 16;514(7522):372-5. doi: 10.1038/nature13590. Epub 2014 Aug 10. PubMed
Saturation editing of genomic regions by multiplex homology-directed repair. Findlay GM, Boyle EA, Hause RJ, Klein JC, Shendure J. Nature. 2014 Sep 4;513(7516):120-3. doi: 10.1038/nature13695. PubMed
TALEN/CRISPR-mediated eGFP knock-in add-on at the OCT4 locus does not impact differentiation of human embryonic stem cells towards endoderm. Krentz NA, Nian C, Lynn FC. PLoS One. 2014 Dec 4;9(12):e114275. doi: 10.1371/journal.pone.0114275. eCollection 2014. PubMed
Generation of genomic deletions in mammalian cell lines via CRISPR/Cas9. Bauer DE, Canver MC, Orkin SH. J Vis Exp. 2014 Jan 3;(95). doi: 10.3791/52118. PubMed
FoxO3a suppresses the senescence of cardiac microvascular endothelial cells by regulating the ROS-mediated cell cycle. Qi XF, Chen ZY, Xia JB, Zheng L, Zhao H, Pi LQ, Park KS, Kim SK, Lee KJ, Cai DQ. J Mol Cell Cardiol. 2015 Apr;81:114-26. doi: 10.1016/j.yjmcc.2015.01.022. Epub 2015 Feb 2. PubMed
Generation of a Knockout Mouse Embryonic Stem Cell Line Using a Paired CRISPR/Cas9 Genome Engineering Tool. Wettstein R, Bodak M, Ciaudo C. Methods Mol Biol. 2015 Mar 12. PubMed
Hepatitis C virus RNA functionally sequesters miR-122. Luna JM, Scheel TK, Danino T, Shaw KS, Mele A, Fak JJ, Nishiuchi E, Takacs CN, Catanese MT, de Jong YP, Jacobson IM, Rice CM, Darnell RB. Cell. 2015 Mar 12;160(6):1099-110. doi: 10.1016/j.cell.2015.02.025. PubMed
Selective Distal Enhancer Control of the Mmp13 Gene Identified through Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR) Genomic Deletions. Meyer MB, Benkusky NA, Pike JW. J Biol Chem. 2015 Apr 24;290(17):11093-107. doi: 10.1074/jbc.M115.648394. Epub 2015 Mar 15. PubMed
Context-specific function of the LIM homeobox 1 transcription factor in head formation of the mouse embryo. Fossat N, Ip CK, Jones VJ, Studdert JB, Khoo PL, Lewis SL, Power M, Tourle K, Loebel DA, Kwan KM, Behringer RR, Tam PP. Development. 2015 Jun 1;142(11):2069-79. doi: 10.1242/dev.120907. Epub 2015 May 14. PubMed
Regulation of Gene Editing Activity Directed by Single-Stranded Oligonucleotides and CRISPR/Cas9 Systems. Bialk P, Rivera-Torres N, Strouse B, Kmiec EB. PLoS One. 2015 Jun 8;10(6):e0129308. doi: 10.1371/journal.pone.0129308. eCollection 2015. PubMed
Protein Kinase A Opposes the Phosphorylation-Dependent Recruitment of Glycogen Synthase Kinase 3beta to A-Kinase Anchoring Protein 220. Whiting JL, Nygren PJ, Tunquist BJ, Langeberg LK, Seternes OM, Scott JD. J Biol Chem. 2015 Jun 18. pii: jbc.M115.654822. PubMed
Keratin-dependent regulation of Aire and gene expression in skin tumor keratinocytes. Hobbs RP, DePianto DJ, Jacob JT, Han MC, Chung BM, Batazzi AS, Poll BG, Guo Y, Han J, Ong S, Zheng W, Taube JM, Cihakova D, Wan F, Coulombe PA. Nat Genet. 2015 Aug;47(8):933-8. doi: 10.1038/ng.3355. Epub 2015 Jul 13. PubMed
Generation of a conditional analog-sensitive kinase in human cells using CRISPR/Cas9-mediated genome engineering. Moyer TC, Holland AJ. Methods Cell Biol. 2015;129:19-36. doi: 10.1016/bs.mcb.2015.03.017. Epub 2015 May 27. PubMed
CETCh-seq: CRISPR epitope tagging ChIP-seq of DNA-binding proteins. Savic D, Partridge EC, Newberry KM, Smith SB, Meadows SK, Roberts BS, Mackiewicz M, Mendenhall EM, Myers RM. Genome Res. 2015 Sep 9. PubMed Associated Plasmids pFETCh_Donor (EMM0021) PX458_CEBPB_1 PX458_CEBPB_2 pFETCh_CEBPB pFETCh_RAD21 More ...
Impaired PIEZO1 function in patients with a novel autosomal recessive congenital lymphatic dysplasia. Lukacs V, Mathur J, Mao R, Bayrak-Toydemir P, Procter M, Cahalan SM, Kim HJ, Bandell M, Longo N, Day RW, Stevenson DA, Patapoutian A, Krock BL. Nat Commun. 2015 Sep 21;6:8329. doi: 10.1038/ncomms9329. PubMed
Genomic Determinants of THAP11/ZNF143/HCFC1 Complex Recruitment to Chromatin. Vinckevicius A, Parker JB, Chakravarti D. Mol Cell Biol. 2015 Dec 15;35(24):4135-46. doi: 10.1128/MCB.00477-15. Epub 2015 Sep 28. PubMed
The adherens junctions control susceptibility to Staphylococcus aureus alpha-toxin. Popov LM, Marceau CD, Starkl PM, Lumb JH, Shah J, Guerrera D, Cooper RL, Merakou C, Bouley DM, Meng W, Kiyonari H, Takeichi M, Galli SJ, Bagnoli F, Citi S, Carette JE, Amieva MR. Proc Natl Acad Sci U S A. 2015 Nov 17;112(46):14337-42. doi: 10.1073/pnas.1510265112. Epub 2015 Oct 21. PubMed
Mechanisms of Enhancer-mediated Hormonal Control of Vitamin D Receptor Gene Expression in Target Cells. Lee SM, Meyer MB, Benkusky NA, O'Brien CA, Pike JW. J Biol Chem. 2015 Dec 18;290(51):30573-86. doi: 10.1074/jbc.M115.693614. Epub 2015 Oct 25. PubMed
Integrin alpha4beta1 controls G9a activity that regulates epigenetic changes and nuclear properties required for lymphocyte migration. Zhang X, Cook PC, Zindy E, Williams CJ, Jowitt TA, Streuli CH, MacDonald AS, Redondo-Munoz J. Nucleic Acids Res. 2015 Dec 10. pii: gkv1348. PubMed
A facile one-step strategy for the generation of conditional knockout mice to explore the role of Notch1 in oroesophageal tumorigenesis. Mandasari M, Sawangarun W, Katsube K, Kayamori K, Yamaguchi A, Sakamoto K. Biochem Biophys Res Commun. 2016 Jan 15;469(3):761-7. doi: 10.1016/j.bbrc.2015.12.006. Epub 2015 Dec 9. PubMed
Spell Checking Nature: Versatility of CRISPR/Cas9 for Developing Treatments for Inherited Disorders. Wojtal D, Kemaladewi DU, Malam Z, Abdullah S, Wong TW, Hyatt E, Baghestani Z, Pereira S, Stavropoulos J, Mouly V, Mamchaoui K, Muntoni F, Voit T, Gonorazky HD, Dowling JJ, Wilson MD, Mendoza-Londono R, Ivakine EA, Cohn RD. Am J Hum Genet. 2016 Jan 7;98(1):90-101. doi: 10.1016/j.ajhg.2015.11.012. Epub 2015 Dec 10. PubMed
Yap and Taz play a crucial role in neural crest-derived craniofacial development. Wang J, Xiao Y, Hsu CW, Martinez-Traverso IM, Zhang M, Bai Y, Ishii M, Maxson RE, Olson EN, Dickinson ME, Wythe JD, Martin JF. Development. 2016 Feb 1;143(3):504-15. doi: 10.1242/dev.126920. Epub 2015 Dec 30. PubMed
A mouse model for adult cardiac-specific gene deletion with CRISPR/Cas9. Carroll KJ, Makarewich CA, McAnally J, Anderson DM, Zentilin L, Liu N, Giacca M, Bassel-Duby R, Olson EN. Proc Natl Acad Sci U S A. 2016 Jan 12;113(2):338-43. doi: 10.1073/pnas.1523918113. Epub 2015 Dec 30. PubMed
Distinct effects of beta1 integrin on cell proliferation and cellular signaling in MDA-MB-231 breast cancer cells. Hou S, Isaji T, Hang Q, Im S, Fukuda T, Gu J. Sci Rep. 2016 Jan 5;6:18430. doi: 10.1038/srep18430. PubMed
Comparison of surrogate reporter systems for enrichment of cells with mutations induced by genome editors. He Z, Shi X, Liu M, Sun G, Proudfoot C, Whitelaw CB, Lillico SG, Chen Y. J Biotechnol. 2016 Jan 14;221:49-54. doi: 10.1016/j.jbiotec.2016.01.009. PubMed
Efficient Restoration of the Dystrophin Gene Reading Frame and Protein Structure in DMD Myoblasts Using the CinDel Method. Iyombe-Engembe JP, Ouellet DL, Barbeau X, Rousseau J, Chapdelaine P, Lague P, Tremblay JP. Mol Ther Nucleic Acids. 2016 Jan 26;5:e283. doi: 10.1038/mtna.2015.58. PubMed
An essential receptor for adeno-associated virus infection. Pillay S, Meyer NL, Puschnik AS, Davulcu O, Diep J, Ishikawa Y, Jae LT, Wosen JE, Nagamine CM, Chapman MS, Carette JE. Nature. 2016 Feb 4;530(7588):108-12. doi: 10.1038/nature16465. Epub 2016 Jan 27. PubMed Associated Plasmids pLenti-CMV-Puro-AAVR-FLAG pLenti-CMV-Puro-miniAAVR-FLAG
Mitotic Diversity in Homeostatic Human Interfollicular Epidermis. Noske K, Stark HJ, Nevaril L, Berning M, Langbein L, Goyal A, Diederichs S, Boukamp P. Int J Mol Sci. 2016 Jan 28;17(2). pii: E167. doi: 10.3390/ijms17020167. PubMed
Phosphorylation-Dependent Regulation of the DNA Damage Response of Adaptor Protein KIBRA in Cancer Cells. Mavuluri J, Beesetti S, Surabhi R, Kremerskothen J, Venkatraman G, Rayala SK. Mol Cell Biol. 2016 Apr 15;36(9):1354-65. doi: 10.1128/MCB.01004-15. Print 2016 May 1. PubMed
AMPK governs lineage specification through Tfeb-dependent regulation of lysosomes. Young NP, Kamireddy A, Van Nostrand JL, Eichner LJ, Shokhirev MN, Dayn Y, Shaw RJ. Genes Dev. 2016 Mar 1;30(5):535-52. doi: 10.1101/gad.274142.115. PubMed Associated Plasmids Cas9-GFP_sg_mAMPKa1 Cas9-GFP_sg_mAMPKa2 Cas9-GFP_sg_mTfeb pCIP pCIP-AMPKa1_WT More ...
Psychiatric Risk Gene Transcription Factor 4 Regulates Intrinsic Excitability of Prefrontal Neurons via Repression of SCN10a and KCNQ1. Rannals MD, Hamersky GR, Page SC, Campbell MN, Briley A, Gallo RA, Phan BN, Hyde TM, Kleinman JE, Shin JH, Jaffe AE, Weinberger DR, Maher BJ. Neuron. 2016 Apr 6;90(1):43-55. doi: 10.1016/j.neuron.2016.02.021. Epub 2016 Mar 10. PubMed
Programmable RNA Tracking in Live Cells with CRISPR/Cas9. Nelles DA, Fang MY, O'Connell MR, Xu JL, Markmiller SJ, Doudna JA, Yeo GW. Cell. 2016 Mar 16. pii: S0092-8674(16)30204-5. doi: 10.1016/j.cell.2016.02.054. PubMed Associated Plasmids pBluescriptSKII+ U6-sgRNA(F+E) ACTB pBluescriptSKII+ U6-sgRNA(F+E) empty pBluescriptSKII+ U6-sgRNA(F+E) TFRC pCDNA3.1- dCas9-2xNLS-EGFP
PLEKHA7 Recruits PDZD11 to Adherens Junctions to Stabilize Nectins. Guerrera D, Shah J, Vasileva E, Sluysmans S, Mean I, Jond L, Poser I, Mann M, Hyman AA, Citi S. J Biol Chem. 2016 May 20;291(21):11016-29. doi: 10.1074/jbc.M115.712935. Epub 2016 Apr 4. PubMed Associated Plasmids hPDZD11-HA
Inhibition of HSV-1 Replication by Gene Editing Strategy. Roehm PC, Shekarabi M, Wollebo HS, Bellizzi A, He L, Salkind J, Khalili K. Sci Rep. 2016 Apr 11;6:23146. doi: 10.1038/srep23146. PubMed
Histone H3 globular domain acetylation identifies a new class of enhancers. Pradeepa MM, Grimes GR, Kumar Y, Olley G, Taylor GC, Schneider R, Bickmore WA. Nat Genet. 2016 Jun;48(6):681-6. doi: 10.1038/ng.3550. Epub 2016 Apr 18. PubMed
CRISPR/Cas9 knockout of HAS2 in rat chondrosarcoma chondrocytes demonstrates the requirement of hyaluronan for aggrecan retention. Huang Y, Askew EB, Knudson CB, Knudson W. Matrix Biol. 2016 Dec;56:74-94. doi: 10.1016/j.matbio.2016.04.002. Epub 2016 Apr 14. PubMed
Sphingosine-1-Phosphate Lyase Deficient Cells as a Tool to Study Protein Lipid Interactions. Gerl MJ, Bittl V, Kirchner S, Sachsenheimer T, Brunner HL, Luchtenborg C, Ozbalci C, Wiedemann H, Wegehingel S, Nickel W, Haberkant P, Schultz C, Kruger M, Brugger B. PLoS One. 2016 Apr 21;11(4):e0153009. doi: 10.1371/journal.pone.0153009. eCollection 2016. PubMed
ISL1 and JMJD3 synergistically control cardiac differentiation of embryonic stem cells. Wang Y, Li Y, Guo C, Lu Q, Wang W, Jia Z, Chen P, Ma K, Reinberg D, Zhou C. Nucleic Acids Res. 2016 Apr 21. pii: gkw301. PubMed
Expression of MLL-AF4 or AF4-MLL fusions does not impact the efficiency of DNA damage repair. Castano J, Herrero AB, Bursen A, Gonzalez F, Marschalek R, Gutierrez NC, Menendez P. Oncotarget. 2016 May 24;7(21):30440-52. doi: 10.18632/oncotarget.8938. PubMed
Plet1 is an epigenetically regulated cell surface protein that provides essential cues to direct trophoblast stem cell differentiation. Murray A, Sienerth AR, Hemberger M. Sci Rep. 2016 Apr 28;6:25112. doi: 10.1038/srep25112. PubMed
AMPK Causes Cell Cycle Arrest in LKB1-deficient Cells via Activation of CAMKK2. Fogarty S, Ross FA, Vara Ciruelos D, Gray A, Gowans GJ, Hardie DG. Mol Cancer Res. 2016 May 2. pii: molcanres.0479.2015. PubMed
The recombined cccDNA produced using minicircle technology mimicked HBV genome in structure and function closely. Guo X, Chen P, Hou X, Xu W, Wang D, Wang TY, Zhang L, Zheng G, Gao ZL, He CY, Zhou B, Chen ZY. Sci Rep. 2016 May 13;6:25552. doi: 10.1038/srep25552. PubMed
The DNA Structure-Specific Endonuclease MUS81 Mediates DNA Sensor STING-Dependent Host Rejection of Prostate Cancer Cells. Ho SS, Zhang WY, Tan NY, Khatoo M, Suter MA, Tripathi S, Cheung FS, Lim WK, Tan PH, Ngeow J, Gasser S. Immunity. 2016 May 17;44(5):1177-89. doi: 10.1016/j.immuni.2016.04.010. Epub 2016 May 10. PubMed
The Evx1/Evx1as gene locus regulates anterior-posterior patterning during gastrulation. Bell CC, Amaral PP, Kalsbeek A, Magor GW, Gillinder KR, Tangermann P, di Lisio L, Cheetham SW, Gruhl F, Frith J, Tallack MR, Ru KL, Crawford J, Mattick JS, Dinger ME, Perkins AC. Sci Rep. 2016 May 26;6:26657. doi: 10.1038/srep26657. PubMed
Pitx2 promotes heart repair by activating the antioxidant response after cardiac injury. Tao G, Kahr PC, Morikawa Y, Zhang M, Rahmani M, Heallen TR, Li L, Sun Z, Olson EN, Amendt BA, Martin JF. Nature. 2016 Jun 2;534(7605):119-23. doi: 10.1038/nature17959. PubMed
Aberrant PD-L1 expression through 3'-UTR disruption in multiple cancers. Kataoka K, Shiraishi Y, Takeda Y, Sakata S, Matsumoto M, Nagano S, Maeda T, Nagata Y, Kitanaka A, Mizuno S, Tanaka H, Chiba K, Ito S, Watatani Y, Kakiuchi N, Suzuki H, Yoshizato T, Yoshida K, Sanada M, Itonaga H, Imaizumi Y, Totoki Y, Munakata W, Nakamura H, Hama N, Shide K, Kubuki Y, Hidaka T, Kameda T, Masuda K, Minato N, Kashiwase K, Izutsu K, Takaori-Kondo A, Miyazaki Y, Takahashi S, Shibata T, Kawamoto H, Akatsuka Y, Shimoda K, Takeuchi K, Seya T, Miyano S, Ogawa S. Nature. 2016 Jun 16;534(7607):402-6. doi: 10.1038/nature18294. PubMed
Combination of the clustered regularly interspaced short palindromic repeats (CRISPR)-associated 9 technique with the piggybac transposon system for mouse in utero electroporation to study cortical development. Cheng M, Jin X, Mu L, Wang F, Li W, Zhong X, Liu X, Shen W, Liu Y, Zhou Y. J Neurosci Res. 2016 Jun 18. doi: 10.1002/jnr.23776. PubMed
TCF7L1 Modulates Colorectal Cancer Growth by Inhibiting Expression of the Tumor-Suppressor Gene EPHB3. Murphy M, Chatterjee SS, Jain S, Katari M, DasGupta R. Sci Rep. 2016 Jun 23;6:28299. doi: 10.1038/srep28299. PubMed
Opposing Roles of Double-Stranded RNA Effector Pathways and Viral Defense Proteins Revealed with CRISPR/Cas9 Knock-Out Cell Lines and Vaccinia Virus Mutants. Liu R, Moss B. J Virol. 2016 Jun 22. pii: JVI.00869-16. PubMed
AP1S3 Mutations Cause Skin Autoinflammation by Disrupting Keratinocyte Autophagy and Up-Regulating IL-36 Production. Mahil SK, Twelves S, Farkas K, Setta-Kaffetzi N, Burden AD, Gach JE, Irvine AD, Kepiro L, Mockenhaupt M, Oon HH, Pinner J, Ranki A, Seyger MM, Soler-Palacin P, Storan ER, Tan ES, Valeyrie-Allanore L, Young HS, Trembath RC, Choon SE, Szell M, Bata-Csorgo Z, Smith CH, Di Meglio P, Barker JN, Capon F. J Invest Dermatol. 2016 Nov;136(11):2251-2259. doi: 10.1016/j.jid.2016.06.618. Epub 2016 Jul 5. PubMed
Identification and validation of regulatory SNPs that modulate transcription factor chromatin binding and gene expression in prostate cancer. Jin HJ, Jung S, DebRoy AR, Davuluri RV. Oncotarget. 2016 Aug 23;7(34):54616-54626. doi: 10.18632/oncotarget.10520. PubMed
A USP28-53BP1-p53-p21 signaling axis arrests growth after centrosome loss or prolonged mitosis. Lambrus BG, Daggubati V, Uetake Y, Scott PM, Clutario KM, Sluder G, Holland AJ. J Cell Biol. 2016 Jul 18;214(2):143-53. doi: 10.1083/jcb.201604054. PubMed
Co-incident insertion enables high efficiency genome engineering in mouse embryonic stem cells. Shy BR, MacDougall MS, Clarke R, Merrill BJ. Nucleic Acids Res. 2016 Aug 2. pii: gkw685. PubMed
Biallelic inactivation of REV7 is associated with Fanconi anemia. Bluteau D, Masliah-Planchon J, Clairmont C, Rousseau A, Ceccaldi R, Dubois d'Enghien C, Bluteau O, Cuccuini W, Gachet S, Peffault de Latour R, Leblanc T, Socie G, Baruchel A, Stoppa-Lyonnet D, D'Andrea AD, Soulier J. J Clin Invest. 2016 Sep 1;126(9):3580-4. doi: 10.1172/JCI88010. Epub 2016 Aug 8. PubMed
Chromatin-Remodeling Complex SWI/SNF Controls Multidrug Resistance by Transcriptionally Regulating the Drug Efflux Pump ABCB1. Dubey R, Lebensohn AM, Bahrami-Nejad Z, Marceau C, Champion M, Gevaert O, Sikic BI, Carette JE, Rohatgi R. Cancer Res. 2016 Oct 1;76(19):5810-5821. Epub 2016 Aug 8. PubMed
Keratin 17 Is Induced in Oral Cancer and Facilitates Tumor Growth. Khanom R, Nguyen CT, Kayamori K, Zhao X, Morita K, Miki Y, Katsube K, Yamaguchi A, Sakamoto K. PLoS One. 2016 Aug 11;11(8):e0161163. doi: 10.1371/journal.pone.0161163. eCollection 2016. PubMed
A genome-editing strategy to treat beta-hemoglobinopathies that recapitulates a mutation associated with a benign genetic condition. Traxler EA, Yao Y, Wang YD, Woodard KJ, Kurita R, Nakamura Y, Hughes JR, Hardison RC, Blobel GA, Li C, Weiss MJ. Nat Med. 2016 Sep;22(9):987-90. doi: 10.1038/nm.4170. Epub 2016 Aug 15. PubMed
The long non-coding RNA Morrbid regulates Bim and short-lived myeloid cell lifespan. Kotzin JJ, Spencer SP, McCright SJ, Kumar DB, Collet MA, Mowel WK, Elliott EN, Uyar A, Makiya MA, Dunagin MC, Harman CC, Virtue AT, Zhu S, Bailis W, Stein J, Hughes C, Raj A, Wherry EJ, Goff LA, Klion AD, Rinn JL, Williams A, Flavell RA, Henao-Mejia J. Nature. 2016 Sep 8;537(7619):239-243. doi: 10.1038/nature19346. Epub 2016 Aug 15. PubMed
Telomeric RNAs are essential to maintain telomeres. Montero JJ, Lopez de Silanes I, Grana O, Blasco MA. Nat Commun. 2016 Aug 17;7:12534. doi: 10.1038/ncomms12534. PubMed
Immunogenomic engineering of a plug-and-(dis)play hybridoma platform. Pogson M, Parola C, Kelton WJ, Heuberger P, Reddy ST. Nat Commun. 2016 Aug 17;7:12535. doi: 10.1038/ncomms12535. PubMed
Comprehensive Protocols for CRISPR/Cas9-based Gene Editing in Human Pluripotent Stem Cells. Santos DP, Kiskinis E, Eggan K, Merkle FT. Curr Protoc Stem Cell Biol. 2016 Aug 17;38:5B.6.1-5B.6.60. doi: 10.1002/cpsc.15. PubMed
PLEKHG3 enhances polarized cell migration by activating actin filaments at the cell front. Nguyen TT, Park WS, Park BO, Kim CY, Oh Y, Kim JM, Choi H, Kyung T, Kim CH, Lee G, Hahn KM, Meyer T, Heo WD. Proc Natl Acad Sci U S A. 2016 Sep 6;113(36):10091-6. doi: 10.1073/pnas.1604720113. Epub 2016 Aug 23. PubMed
An endosomal tether undergoes an entropic collapse to bring vesicles together. Murray DH, Jahnel M, Lauer J, Avellaneda MJ, Brouilly N, Cezanne A, Morales-Navarrete H, Perini ED, Ferguson C, Lupas AN, Kalaidzidis Y, Parton RG, Grill SW, Zerial M. Nature. 2016 Sep 1;537(7618):107-111. doi: 10.1038/nature19326. Epub 2016 Aug 24. PubMed
Analyses of point mutation repair and allelic heterogeneity generated by CRISPR/Cas9 and single-stranded DNA oligonucleotides. Bialk P, Sansbury B, Rivera-Torres N, Bloh K, Man D, Kmiec EB. Sci Rep. 2016 Sep 9;6:32681. doi: 10.1038/srep32681. PubMed
Accessory subunits are integral for assembly and function of human mitochondrial complex I. Stroud DA, Surgenor EE, Formosa LE, Reljic B, Frazier AE, Dibley MG, Osellame LD, Stait T, Beilharz TH, Thorburn DR, Salim A, Ryan MT. Nature. 2016 Oct 6;538(7623):123-126. doi: 10.1038/nature19754. Epub 2016 Sep 14. PubMed
Tumor-specific CD4+ T cells eradicate myeloma cells genetically deficient in MHC class II display. Tveita A, Fauskanger M, Bogen B, Haabeth OA. Oncotarget. 2016 Oct 11;7(41):67175-67182. doi: 10.18632/oncotarget.11946. PubMed
Identification of Novel Nuclear Factor of Activated T Cells (NFAT)-Associated Proteins in T cells. Gabriel CH, Gross F, Karl M, Stephanowitz H, Hennig AF, Weber M, Gryzik S, Bachmann I, Hecklau K, Wienands J, Schuchhardt J, Herzel H, Radbruch A, Krause E, Baumgrass R. J Biol Chem. 2016 Sep 16. pii: jbc.M116.739326. PubMed Associated Plasmids pMSCV-FLAG-hIKAROS-IRES-GFP pMSCV-FLAG-hHelios-IRES-GFP pMIG-hNFATc1/bC pMIG-hNFATc2 pMIG-hH4-AVITEV More ...
Direct reprogramming of urine-derived cells with inducible MyoD for modeling human muscle disease. Kim EY, Page P, Dellefave-Castillo LM, McNally EM, Wyatt EJ. Skelet Muscle. 2016 Sep 15;6:32. doi: 10.1186/s13395-016-0103-9. eCollection 2016. PubMed
A Recurrent ERCC3 Truncating Mutation Confers Moderate Risk for Breast Cancer. Vijai J, Topka S, Villano D, Ravichandran V, Maxwell KN, Maria A, Thomas T, Gaddam P, Lincoln A, Kazzaz S, Wenz B, Carmi S, Schrader KA, Hart SN, Lipkin SM, Neuhausen SL, Walsh MF, Zhang L, Lejbkowicz F, Rennert H, Stadler ZK, Robson M, Weitzel JN, Domchek S, Daly MJ, Couch FJ, Nathanson KL, Norton L, Rennert G, Offit K. Cancer Discov. 2016 Nov;6(11):1267-1275. Epub 2016 Sep 21. PubMed
TRIMs and Galectins Globally Cooperate and TRIM16 and Galectin-3 Co-direct Autophagy in Endomembrane Damage Homeostasis. Chauhan S, Kumar S, Jain A, Ponpuak M, Mudd MH, Kimura T, Choi SW, Peters R, Mandell M, Bruun JA, Johansen T, Deretic V. Dev Cell. 2016 Oct 10;39(1):13-27. doi: 10.1016/j.devcel.2016.08.003. Epub 2016 Sep 29. PubMed
Activation of Notch1 synergizes with multiple pathways in promoting castration-resistant prostate cancer. Stoyanova T, Riedinger M, Lin S, Faltermeier CM, Smith BA, Zhang KX, Going CC, Goldstein AS, Lee JK, Drake JM, Rice MA, Hsu EC, Nowroozizadeh B, Castor B, Orellana SY, Blum SM, Cheng D, Pienta KJ, Reiter RE, Pitteri SJ, Huang J, Witte ON. Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):E6457-E6466. Epub 2016 Sep 30. PubMed
Challenges of CRISPR/Cas9 applications for long non-coding RNA genes. Goyal A, Myacheva K, Gross M, Klingenberg M, Duran Arque B, Diederichs S. Nucleic Acids Res. 2016 Sep 30. pii: gkw883. PubMed
PAXX Is an Accessory c-NHEJ Factor that Associates with Ku70 and Has Overlapping Functions with XLF. Tadi SK, Tellier-Lebegue C, Nemoz C, Drevet P, Audebert S, Roy S, Meek K, Charbonnier JB, Modesti M. Cell Rep. 2016 Oct 4;17(2):541-555. doi: 10.1016/j.celrep.2016.09.026. PubMed
Retinol and ascorbate drive erasure of epigenetic memory and enhance reprogramming to naive pluripotency by complementary mechanisms. Hore TA, von Meyenn F, Ravichandran M, Bachman M, Ficz G, Oxley D, Santos F, Balasubramanian S, Jurkowski TP, Reik W. Proc Natl Acad Sci U S A. 2016 Oct 25;113(43):12202-12207. Epub 2016 Oct 11. PubMed
The poly(ADP-ribose)-dependent chromatin remodeler Alc1 induces local chromatin relaxation upon DNA damage. Sellou H, Lebeaupin T, Chapuis C, Smith R, Hegele A, Singh HR, Kozlowski M, Bultmann S, Ladurner AG, Timinszky G, Huet S. Mol Biol Cell. 2016 Dec 1;27(24):3791-3799. Epub 2016 Oct 12. PubMed
Essential role of the Dishevelled DEP domain in a Wnt-dependent human-cell-based complementation assay. Gammons MV, Rutherford TJ, Steinhart Z, Angers S, Bienz M. J Cell Sci. 2016 Oct 15;129(20):3892-3902. PubMed Associated Plasmids pBabe-Dvl2-GFP
SIKs control osteocyte responses to parathyroid hormone. Wein MN, Liang Y, Goransson O, Sundberg TB, Wang J, Williams EA, O'Meara MJ, Govea N, Beqo B, Nishimori S, Nagano K, Brooks DJ, Martins JS, Corbin B, Anselmo A, Sadreyev R, Wu JY, Sakamoto K, Foretz M, Xavier RJ, Baron R, Bouxsein ML, Gardella TJ, Divieti-Pajevic P, Gray NS, Kronenberg HM. Nat Commun. 2016 Oct 19;7:13176. doi: 10.1038/ncomms13176. PubMed
Non-SMC Element 2 (NSMCE2) of the SMC5/6 Complex Helps to Resolve Topological Stress. Verver DE, Zheng Y, Speijer D, Hoebe R, Dekker HL, Repping S, Stap J, Hamer G. Int J Mol Sci. 2016 Oct 26;17(11). pii: ijms17111782. doi: 10.3390/ijms17111782. PubMed
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Efficient generation of targeted and controlled mutational events in porcine cells using nuclease-directed homologous recombination. Butler JR, Santos RMN, Martens GR, Ladowski JM, Wang ZY, Li P, Tector M, Tector AJ. J Surg Res. 2017 May 15;212:238-245. doi: 10.1016/j.jss.2017.01.025. Epub 2017 Jan 29. PubMed
Biallelic Mutations in CFAP43 and CFAP44 Cause Male Infertility with Multiple Morphological Abnormalities of the Sperm Flagella. Tang S, Wang X, Li W, Yang X, Li Z, Liu W, Li C, Zhu Z, Wang L, Wang J, Zhang L, Sun X, Zhi E, Wang H, Li H, Jin L, Luo Y, Wang J, Yang S, Zhang F. Am J Hum Genet. 2017 Jun 1;100(6):854-864. doi: 10.1016/j.ajhg.2017.04.012. Epub 2017 May 25. PubMed
Nucleus-Translocated ACSS2 Promotes Gene Transcription for Lysosomal Biogenesis and Autophagy. Li X, Yu W, Qian X, Xia Y, Zheng Y, Lee JH, Li W, Lyu J, Rao G, Zhang X, Qian CN, Rozen SG, Jiang T, Lu Z. Mol Cell. 2017 Jun 1;66(5):684-697.e9. doi: 10.1016/j.molcel.2017.04.026. Epub 2017 May 25. PubMed
Biallelic TRIP13 mutations predispose to Wilms tumor and chromosome missegregation. Yost S, de Wolf B, Hanks S, Zachariou A, Marcozzi C, Clarke M, de Voer R, Etemad B, Uijttewaal E, Ramsay E, Wylie H, Elliott A, Picton S, Smith A, Smithson S, Seal S, Ruark E, Houge G, Pines J, Kops GJPL, Rahman N. Nat Genet. 2017 Jul;49(7):1148-1151. doi: 10.1038/ng.3883. Epub 2017 May 29. PubMed
Myomerger induces fusion of non-fusogenic cells and is required for skeletal muscle development. Quinn ME, Goh Q, Kurosaka M, Gamage DG, Petrany MJ, Prasad V, Millay DP. Nat Commun. 2017 Jun 1;8:15665. doi: 10.1038/ncomms15665. PubMed
SCYL1 does not regulate REST expression and turnover. Gingras S, Kuliyev E, Pelletier S. PLoS One. 2017 Jun 1;12(6):e0178680. doi: 10.1371/journal.pone.0178680. eCollection 2017. PubMed
Low expression of PinX1 is associated with malignant behavior in basal-like breast cancer. Feng YZ, Zhang QY, Fu MT, Zhang ZF, Wei M, Zhou JY, Shi R. Oncol Rep. 2017 Jul;38(1):109-119. doi: 10.3892/or.2017.5696. Epub 2017 Jun 2. PubMed
Intercellular transmission of the unfolded protein response promotes survival and drug resistance in cancer cells. Rodvold JJ, Chiu KT, Hiramatsu N, Nussbacher JK, Galimberti V, Mahadevan NR, Willert K, Lin JH, Zanetti M. Sci Signal. 2017 Jun 6;10(482). pii: 10/482/eaah7177. doi: 10.1126/scisignal.aah7177. PubMed
The beneficial metabolic effects of insulin sensitizers are not attenuated by mitochondrial pyruvate carrier 2 hypomorphism. Vigueira PA, McCommis KS, Hodges WT, Schweitzer GG, Cole SL, Oonthonpan L, Taylor EB, McDonald WG, Kletzien RF, Colca JR, Finck BN. Exp Physiol. 2017 Jun 9. doi: 10.1113/EP086380. PubMed
Mutation of nucleotides around the +1 position of type 3 polymerase III promoters: The effect on transcriptional activity and start site usage. Gao Z, Harwig A, Berkhout B, Herrera-Carrillo E. Transcription. 2017 Jun 9:e1322170. doi: 10.1080/21541264.2017.1322170. PubMed
Reduction of infection by inhibiting mTOR pathway is associated with reversed repression of type I interferon by porcine reproductive and respiratory syndrome virus. Liu Q, Miller LC, Blecha F, Sang Y. J Gen Virol. 2017 Jun;98(6):1316-1328. doi: 10.1099/jgv.0.000802. Epub 2017 Jun 14. PubMed
PTEN counteracts FBXL2 to promote IP3R3- and Ca(2+)-mediated apoptosis limiting tumour growth. Kuchay S, Giorgi C, Simoneschi D, Pagan J, Missiroli S, Saraf A, Florens L, Washburn MP, Collazo-Lorduy A, Castillo-Martin M, Cordon-Cardo C, Sebti SM, Pinton P, Pagano M. Nature. 2017 Jun 22;546(7659):554-558. doi: 10.1038/nature22965. Epub 2017 Jun 14. PubMed Associated Plasmids pEGFPc1 IP3R3 WT pEGFPc1 QFR IP3R3 pcDNA3 FLAG FBXL2 pEGFPc1 PTEN C124S
CRISPR/Cas9-Directed Reassignment of the GATA1 Initiation Codon in K562 Cells to Recapitulate AML in Down Syndrome. Bloh KM, Bialk PA, Gopalakrishnapillai A, Kolb EA, Kmiec EB. Mol Ther Nucleic Acids. 2017 Jun 16;7:288-298. doi: 10.1016/j.omtn.2017.04.009. Epub 2017 Apr 13. PubMed
Extensive Proliferation of Human Cancer Cells with Ever-Shorter Telomeres. Dagg RA, Pickett HA, Neumann AA, Napier CE, Henson JD, Teber ET, Arthur JW, Reynolds CP, Murray J, Haber M, Sobinoff AP, Lau LMS, Reddel RR. Cell Rep. 2017 Jun 20;19(12):2544-2556. doi: 10.1016/j.celrep.2017.05.087. PubMed
Non-canonical Glucocorticoid Receptor Transactivation of gilz by Alcohol Suppresses Cell Inflammatory Response. Ng HP, Jennings S, Wang J, Molina PE, Nelson S, Wang G. Front Immunol. 2017 Jun 7;8:661. doi: 10.3389/fimmu.2017.00661. eCollection 2017. PubMed
Baculoviral delivery of CRISPR/Cas9 facilitates efficient genome editing in human cells. Hindriksen S, Bramer AJ, Truong MA, Vromans MJM, Post JB, Verlaan-Klink I, Snippert HJ, Lens SMA, Hadders MA. PLoS One. 2017 Jun 22;12(6):e0179514. doi: 10.1371/journal.pone.0179514. eCollection 2017. PubMed
KLF1 drives the expression of fetal hemoglobin in British HPFH. Wienert B, Martyn GE, Kurita R, Nakamura Y, Quinlan KGR, Crossley M. Blood. 2017 Jun 28. pii: blood-2017-02-767400. doi: 10.1182/blood-2017-02-767400. PubMed
METTL21B is a novel human lysine methyltransferase of translation elongation factor 1A: discovery by CRISPR/Cas9 knock out. Hamey JJ, Wienert B, Quinlan KGR, Wilkins MR. Mol Cell Proteomics. 2017 Jun 29. pii: mcp.M116.066308. doi: 10.1074/mcp.M116.066308. PubMed
Viral Replication Complexes Are Targeted by LC3-Guided Interferon-Inducible GTPases. Biering SB, Choi J, Halstrom RA, Brown HM, Beatty WL, Lee S, McCune BT, Dominici E, Williams LE, Orchard RC, Wilen CB, Yamamoto M, Coers J, Taylor GA, Hwang S. Cell Host Microbe. 2017 Jul 12;22(1):74-85.e7. doi: 10.1016/j.chom.2017.06.005. Epub 2017 Jun 29. PubMed
Generation and characterization of a human iPSC cell line expressing inducible Cas9 in the "safe harbor" AAVS1 locus. Castano J, Bueno C, Jimenez-Delgado S, Roca-Ho H, Fraga MF, Fernandez AF, Nakanishi M, Torres-Ruiz R, Rodriguez-Perales S, Menendez P. Stem Cell Res. 2017 May;21:137-140. doi: 10.1016/j.scr.2017.04.011. Epub 2017 Apr 22. PubMed Associated Plasmids pAAVS1-TRE-Cas9- puro-polyA-CAG-rtTA
Generation of a Bag1 homozygous knockout mouse embryonic stem cell line using CRISPR/Cas9. Tang CC, Shan LP, Wang WM, Lu G, Tare RS, Lee KKH. Stem Cell Res. 2017 May;21:29-31. doi: 10.1016/j.scr.2017.03.016. Epub 2017 Mar 23. PubMed
The host E3-Ubiquitin ligase TRIM6 ubiquitinates the Ebola virus VP35 protein and promotes virus replication. Bharaj P, Atkins C, Luthra P, Giraldo MI, Dawes BE, Miorin L, Johnson JR, Krogan NJ, Basler CF, Freiberg AN, Rajsbaum R. J Virol. 2017 Jul 5. pii: JVI.00833-17. doi: 10.1128/JVI.00833-17. PubMed
A Type 2 Diabetes-Associated Functional Regulatory Variant in a Pancreatic Islet Enhancer at the Adcy5 Locus. Roman TS, Cannon ME, Vadlamudi S, Buchkovich ML, Wolford BN, Welch RP, Morken MA, Kwon GJ, Varshney A, Kursawe R, Wu Y, Jackson AU, Erdos MR, Kuusisto J, Laakso M, Scott LJ, Boehnke M, Collins FS, Parker SCJ, Stitzel ML, Mohlke KL. Diabetes. 2017 Jul 6. pii: db170464. doi: 10.2337/db17-0464. PubMed
Inactivation of Pol theta and C-NHEJ eliminates off-target integration of exogenous DNA. Zelensky AN, Schimmel J, Kool H, Kanaar R, Tijsterman M. Nat Commun. 2017 Jul 7;8(1):66. doi: 10.1038/s41467-017-00124-3. PubMed
Wnt-Dependent Inactivation of the Groucho/TLE Co-repressor by the HECT E3 Ubiquitin Ligase Hyd/UBR5. Flack JE, Mieszczanek J, Novcic N, Bienz M. Mol Cell. 2017 Jul 20;67(2):181-193.e5. doi: 10.1016/j.molcel.2017.06.009. Epub 2017 Jul 6. PubMed
The Guanine-Nucleotide Exchange Factor Caldag Gefi Fine-Tunes Functional Properties of Regulatory T Cells. Niemz J, Kliche S, Pils MC, Morrison E, Manns A, Freund C, Crittenden JR, Graybiel AM, Galla M, Jansch L, Huehn J. Eur J Microbiol Immunol (Bp). 2017 May 22;7(2):112-126. doi: 10.1556/1886.2017.00007. eCollection 2017 Jun. PubMed
Targeted DNA methylation in vivo using an engineered dCas9-MQ1 fusion protein. Lei Y, Zhang X, Su J, Jeong M, Gundry MC, Huang YH, Zhou Y, Li W, Goodell MA. Nat Commun. 2017 Jul 11;8:16026. doi: 10.1038/ncomms16026. PubMed Associated Plasmids pcDNA3.1-dCas9-MQ1(WT)-EGFP pcDNA3.1-dCas9-MQ1(C141S)-EGFP pcDNA3.1-dCas9-MQ1(S317A)-EGFP pcDNA3.1-dCas9-dMQ1-EGFP pLV hUbC-dCas9-MQ1(Q147L)-EGFP More ...
tsRNA signatures in cancer. Balatti V, Nigita G, Veneziano D, Drusco A, Stein GS, Messier TL, Farina NH, Lian JB, Tomasello L, Liu CG, Palamarchuk A, Hart JR, Bell C, Carosi M, Pescarmona E, Perracchio L, Diodoro M, Russo A, Antenucci A, Visca P, Ciardi A, Harris CC, Vogt PK, Pekarsky Y, Croce CM. Proc Natl Acad Sci U S A. 2017 Jul 25;114(30):8071-8076. doi: 10.1073/pnas.1706908114. Epub 2017 Jul 10. PubMed
Exosome RNA Unshielding Couples Stromal Activation to Pattern Recognition Receptor Signaling in Cancer. Nabet BY, Qiu Y, Shabason JE, Wu TJ, Yoon T, Kim BC, Benci JL, DeMichele AM, Tchou J, Marcotrigiano J, Minn AJ. Cell. 2017 Jul 13;170(2):352-366.e13. doi: 10.1016/j.cell.2017.06.031. PubMed
The ciliary membrane-associated proteome reveals actin-binding proteins as key components of cilia. Kohli P, Hohne M, Jungst C, Bertsch S, Ebert LK, Schauss AC, Benzing T, Rinschen MM, Schermer B. EMBO Rep. 2017 Sep;18(9):1521-1535. doi: 10.15252/embr.201643846. Epub 2017 Jul 14. PubMed
Cytosolic interaction of type III human CD38 with CIB1 modulates cellular cyclic ADP-ribose levels. Liu J, Zhao YJ, Li WH, Hou YN, Li T, Zhao ZY, Fang C, Li SL, Lee HC. Proc Natl Acad Sci U S A. 2017 Jul 18. pii: 1703718114. doi: 10.1073/pnas.1703718114. PubMed
Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK. Zhang CS, Hawley SA, Zong Y, Li M, Wang Z, Gray A, Ma T, Cui J, Feng JW, Zhu M, Wu YQ, Li TY, Ye Z, Lin SY, Yin H, Piao HL, Hardie DG, Lin SC. Nature. 2017 Aug 3;548(7665):112-116. doi: 10.1038/nature23275. Epub 2017 Jul 19. PubMed Associated Plasmids pBoBi-hALDOA pBoBi-hALDOA D34S pBoBi-hALDOA K230A pcDNA3.3-hALDOA pcDNA3.3-hALDOA D34S More ...
Histone demethylase PHF8 regulates hypoxia signaling through HIF1alpha and H3K4me3. Maina PK, Shao P, Jia X, Liu Q, Umesalma S, Marin M, Long D Jr, Concepcion-Roman S, Qi HH. Biochim Biophys Acta Gene Regul Mech. 2017 Sep;1860(9):1002-1012. doi: 10.1016/j.bbagrm.2017.07.005. Epub 2017 Jul 20. PubMed
Argonaute CLIP Defines a Deregulated miR-122-Bound Transcriptome that Correlates with Patient Survival in Human Liver Cancer. Luna JM, Barajas JM, Teng KY, Sun HL, Moore MJ, Rice CM, Darnell RB, Ghoshal K. Mol Cell. 2017 Aug 3;67(3):400-410.e7. doi: 10.1016/j.molcel.2017.06.025. Epub 2017 Jul 20. PubMed
DDX6 Represses Aberrant Activation of Interferon-Stimulated Genes. Lumb JH, Li Q, Popov LM, Ding S, Keith MT, Merrill BD, Greenberg HB, Li JB, Carette JE. Cell Rep. 2017 Jul 25;20(4):819-831. doi: 10.1016/j.celrep.2017.06.085. PubMed
A biallelic mutation in IL6ST encoding the GP130 co-receptor causes immunodeficiency and craniosynostosis. Schwerd T, Twigg SRF, Aschenbrenner D, Manrique S, Miller KA, Taylor IB, Capitani M, McGowan SJ, Sweeney E, Weber A, Chen L, Bowness P, Riordan A, Cant A, Freeman AF, Milner JD, Holland SM, Frede N, Muller M, Schmidt-Arras D, Grimbacher B, Wall SA, Jones EY, Wilkie AOM, Uhlig HH. J Exp Med. 2017 Sep 4;214(9):2547-2562. doi: 10.1084/jem.20161810. Epub 2017 Jul 26. PubMed
A genome-wide CRISPR screen reconciles the role of N-linked glycosylation in galectin-3 transport to the cell surface. Stewart SE, Menzies SA, Popa SJ, Savinykh N, Petrunkina Harrison A, Lehner PJ, Moreau K. J Cell Sci. 2017 Oct 1;130(19):3234-3247. doi: 10.1242/jcs.206425. Epub 2017 Aug 3. PubMed
The Sharpin interactome reveals a role for Sharpin in lamellipodium formation via the Arp2/3 complex. Khan MH, Salomaa SI, Jacquemet G, Butt U, Miihkinen M, Deguchi T, Kremneva E, Lappalainen P, Humphries MJ, Pouwels J. J Cell Sci. 2017 Sep 15;130(18):3094-3107. doi: 10.1242/jcs.200329. Epub 2017 Aug 3. PubMed
Fibroblast growth factor receptor is a mechanistic link between visceral adiposity and cancer. Chakraborty D, Benham V, Bullard B, Kearney T, Hsia HC, Gibbon D, Demireva EY, Lunt SY, Bernard JJ. Oncogene. 2017 Nov 30;36(48):6668-6679. doi: 10.1038/onc.2017.278. Epub 2017 Aug 7. PubMed
Complete Acid Ceramidase ablation prevents cancer-initiating cell formation in melanoma cells. Lai M, Realini N, La Ferla M, Passalacqua I, Matteoli G, Ganesan A, Pistello M, Mazzanti CM, Piomelli D. Sci Rep. 2017 Aug 7;7(1):7411. doi: 10.1038/s41598-017-07606-w. PubMed
A pluripotent stem cell-based model for post-implantation human amniotic sac development. Shao Y, Taniguchi K, Townshend RF, Miki T, Gumucio DL, Fu J. Nat Commun. 2017 Aug 8;8(1):208. doi: 10.1038/s41467-017-00236-w. PubMed
Antibody-mediated blockade of JMJD6 interaction with collagen I exerts antifibrotic and antimetastatic activities. Miotti S, Gulino A, Ferri R, Parenza M, Chronowska A, Lecis D, Sangaletti S, Tagliabue E, Tripodo C, Colombo MP. FASEB J. 2017 Dec;31(12):5356-5370. doi: 10.1096/fj.201700377R. Epub 2017 Aug 8. PubMed
Identification and characterization of a long non-coding RNA up-regulated during HIV-1 infection. Postler TS, Pantry SN, Desrosiers RC, Ghosh S. Virology. 2017 Nov;511:30-39. doi: 10.1016/j.virol.2017.08.006. Epub 2017 Aug 10. PubMed
Improved androgen specificity of AR-EcoScreen by CRISPR based glucocorticoid receptor knockout. Zwart N, Andringa D, de Leeuw WJ, Kojima H, Iida M, Houtman CJ, de Boer J, Kool J, Lamoree MH, Hamers T. Toxicol In Vitro. 2017 Dec;45(Pt 1):1-9. doi: 10.1016/j.tiv.2017.08.004. Epub 2017 Aug 11. PubMed
CRISPR/Cas9 editing of Nf1 gene identifies CRMP2 as a therapeutic target in neurofibromatosis type 1-related pain that is reversed by (S)-Lacosamide. Moutal A, Yang X, Li W, Gilbraith KB, Luo S, Cai S, Francois-Moutal L, Chew LA, Yeon SK, Bellampalli SS, Qu C, Xie JY, Ibrahim MM, Khanna M, Park KD, Porreca F, Khanna R. Pain. 2017 Dec;158(12):2301-2319. doi: 10.1097/j.pain.0000000000001002. PubMed
BORC coordinates encounter and fusion of lysosomes with autophagosomes. Jia R, Guardia CM, Pu J, Chen Y, Bonifacino JS. Autophagy. 2017 Oct 3;13(10):1648-1663. doi: 10.1080/15548627.2017.1343768. Epub 2017 Aug 21. PubMed
Inactivation of CREBBP expands the germinal center B cell compartment, down-regulates MHCII expression and promotes DLBCL growth. Hashwah H, Schmid CA, Kasser S, Bertram K, Stelling A, Manz MG, Muller A. Proc Natl Acad Sci U S A. 2017 Sep 5;114(36):9701-9706. doi: 10.1073/pnas.1619555114. Epub 2017 Aug 22. PubMed
The molecular chaperones DNAJB6 and Hsp70 cooperate to suppress alpha-synuclein aggregation. Aprile FA, Kallstig E, Limorenko G, Vendruscolo M, Ron D, Hansen C. Sci Rep. 2017 Aug 22;7(1):9039. doi: 10.1038/s41598-017-08324-z. PubMed
Pseudomonas aeruginosa ExlA and Serratia marcescens ShlA trigger cadherin cleavage by promoting calcium influx and ADAM10 activation. Reboud E, Bouillot S, Patot S, Beganton B, Attree I, Huber P. PLoS Pathog. 2017 Aug 23;13(8):e1006579. doi: 10.1371/journal.ppat.1006579. eCollection 2017 Aug. PubMed
In Situ Capture of Chromatin Interactions by Biotinylated dCas9. Liu X, Zhang Y, Chen Y, Li M, Zhou F, Li K, Cao H, Ni M, Liu Y, Gu Z, Dickerson KE, Xie S, Hon GC, Xuan Z, Zhang MQ, Shao Z, Xu J. Cell. 2017 Aug 24;170(5):1028-1043.e19. doi: 10.1016/j.cell.2017.08.003. PubMed Associated Plasmids pEF1a-FB-dCas9-puro pEF1a-BirA-V5-neo pSLQ1651-sgRNA(F+E)-sgGal4
Palmitoylation of the ciliary GTPase ARL13b is necessary for its stability and its role in cilia formation. Roy K, Jerman S, Jozsef L, McNamara T, Onyekaba G, Sun Z, Marin EP. J Biol Chem. 2017 Oct 27;292(43):17703-17717. doi: 10.1074/jbc.M117.792937. Epub 2017 Aug 28. PubMed
Differential mast cell outcomes are sensitive to FcepsilonRI-Syk binding kinetics. Schwartz SL, Cleyrat C, Olah MJ, Relich PK, Phillips GK, Hlavacek WS, Lidke KA, Wilson BS, Lidke DS. Mol Biol Cell. 2017 Nov 7;28(23):3397-3414. doi: 10.1091/mbc.E17-06-0350. Epub 2017 Aug 30. PubMed
Editing an alpha-globin enhancer in primary human hematopoietic stem cells as a treatment for beta-thalassemia. Mettananda S, Fisher CA, Hay D, Badat M, Quek L, Clark K, Hublitz P, Downes D, Kerry J, Gosden M, Telenius J, Sloane-Stanley JA, Faustino P, Coelho A, Doondeea J, Usukhbayar B, Sopp P, Sharpe JA, Hughes JR, Vyas P, Gibbons RJ, Higgs DR. Nat Commun. 2017 Sep 4;8(1):424. doi: 10.1038/s41467-017-00479-7. PubMed
miR-33a inhibits cell proliferation and invasion by targeting CAND1 in lung cancer. Kang M, Li Y, Zhao Y, He S, Shi J. Clin Transl Oncol. 2018 Apr;20(4):457-466. doi: 10.1007/s12094-017-1730-2. Epub 2017 Sep 4. PubMed
Mitochondrial fission facilitates the selective mitophagy of protein aggregates. Burman JL, Pickles S, Wang C, Sekine S, Vargas JNS, Zhang Z, Youle AM, Nezich CL, Wu X, Hammer JA, Youle RJ. J Cell Biol. 2017 Oct 2;216(10):3231-3247. doi: 10.1083/jcb.201612106. Epub 2017 Sep 11. PubMed
SOCS1 is an inducible negative regulator of interferon lambda (IFN-lambda)-induced gene expression in vivo. Blumer T, Coto-Llerena M, Duong FHT, Heim MH. J Biol Chem. 2017 Oct 27;292(43):17928-17938. doi: 10.1074/jbc.M117.788877. Epub 2017 Sep 12. PubMed
Autophagy-Dependent Generation of Free Fatty Acids Is Critical for Normal Neutrophil Differentiation. Riffelmacher T, Clarke A, Richter FC, Stranks A, Pandey S, Danielli S, Hublitz P, Yu Z, Johnson E, Schwerd T, McCullagh J, Uhlig H, Jacobsen SEW, Simon AK. Immunity. 2017 Sep 19;47(3):466-480.e5. doi: 10.1016/j.immuni.2017.08.005. Epub 2017 Sep 12. PubMed
Apoptotic Bodies Elicit Gas6-Mediated Migration of AXL-Expressing Tumor Cells. Zweemer AJM, French CB, Mesfin J, Gordonov S, Meyer AS, Lauffenburger DA. Mol Cancer Res. 2017 Dec;15(12):1656-1666. doi: 10.1158/1541-7786.MCR-17-0012. Epub 2017 Sep 18. PubMed
MCAM contributes to the establishment of cell autonomous polarity in myogenic and chondrogenic differentiation. Moreno-Fortuny A, Bragg L, Cossu G, Roostalu U. Biol Open. 2017 Nov 15;6(11):1592-1601. doi: 10.1242/bio.027771. PubMed
Combinatorial genome and protein engineering yields monoclonal antibodies with hypergalactosylation from CHO cells. Chung CY, Wang Q, Yang S, Ponce SA, Kirsch BJ, Zhang H, Betenbaugh MJ. Biotechnol Bioeng. 2017 Dec;114(12):2848-2856. doi: 10.1002/bit.26375. Epub 2017 Sep 19. PubMed
Functional correction of dystrophin actin binding domain mutations by genome editing. Kyrychenko V, Kyrychenko S, Tiburcy M, Shelton JM, Long C, Schneider JW, Zimmermann WH, Bassel-Duby R, Olson EN. JCI Insight. 2017 Sep 21;2(18). pii: 95918. doi: 10.1172/jci.insight.95918. eCollection 2017 Sep 21. PubMed
The non-canonical poly(A) polymerase FAM46C acts as an onco-suppressor in multiple myeloma. Mroczek S, Chlebowska J, Kulinski TM, Gewartowska O, Gruchota J, Cysewski D, Liudkovska V, Borsuk E, Nowis D, Dziembowski A. Nat Commun. 2017 Sep 20;8(1):619. doi: 10.1038/s41467-017-00578-5. PubMed
HGFL-mediated RON signaling supports breast cancer stem cell phenotypes via activation of non-canonical beta-catenin signaling. Ruiz-Torres SJ, Benight NM, Karns RA, Lower EE, Guan JL, Waltz SE. Oncotarget. 2017 Jul 22;8(35):58918-58933. doi: 10.18632/oncotarget.19441. eCollection 2017 Aug 29. PubMed
Cic Loss Promotes Gliomagenesis via Aberrant Neural Stem Cell Proliferation and Differentiation. Yang R, Chen LH, Hansen LJ, Carpenter AB, Moure CJ, Liu H, Pirozzi CJ, Diplas BH, Waitkus MS, Greer PK, Zhu H, McLendon RE, Bigner DD, He Y, Yan H. Cancer Res. 2017 Nov 15;77(22):6097-6108. doi: 10.1158/0008-5472.CAN-17-1018. Epub 2017 Sep 22. PubMed
EHD Proteins Cooperate to Generate Caveolar Clusters and to Maintain Caveolae during Repeated Mechanical Stress. Yeow I, Howard G, Chadwick J, Mendoza-Topaz C, Hansen CG, Nichols BJ, Shvets E. Curr Biol. 2017 Oct 9;27(19):2951-2962.e5. doi: 10.1016/j.cub.2017.07.047. Epub 2017 Sep 21. PubMed
Genome-Wide CRISPR Screen for Essential Cell Growth Mediators in Mutant KRAS Colorectal Cancers. Yau EH, Kummetha IR, Lichinchi G, Tang R, Zhang Y, Rana TM. Cancer Res. 2017 Nov 15;77(22):6330-6339. doi: 10.1158/0008-5472.CAN-17-2043. Epub 2017 Sep 27. PubMed
Diminished PRRX1 Expression Is Associated With Increased Risk of Atrial Fibrillation and Shortening of the Cardiac Action Potential. Tucker NR, Dolmatova EV, Lin H, Cooper RR, Ye J, Hucker WJ, Jameson HS, Parsons VA, Weng LC, Mills RW, Sinner MF, Imakaev M, Leyton-Mange J, Vlahakes G, Benjamin EJ, Lunetta KL, Lubitz SA, Mirny L, Milan DJ, Ellinor PT. Circ Cardiovasc Genet. 2017 Oct;10(5). pii: CIRCGENETICS.117.001902. doi: 10.1161/CIRCGENETICS.117.001902. PubMed
Enhanced Genome Editing Tools For Multi-Gene Deletion Knock-Out Approaches Using Paired CRISPR sgRNAs in CHO Cells. Schmieder V, Bydlinski N, Strasser R, Baumann M, Kildegaard HF, Jadhav V, Borth N. Biotechnol J. 2018 Mar;13(3):e1700211. doi: 10.1002/biot.201700211. Epub 2017 Nov 13. PubMed
TRPC5 is required for the NO-dependent increase in dendritic Ca(2+) and GABA release from chick retinal amacrine cells. Maddox JW, Khorsandi N, Gleason E. J Neurophysiol. 2018 Jan 1;119(1):262-273. doi: 10.1152/jn.00500.2017. Epub 2017 Oct 4. PubMed
Distinct Cell-Cycle Control in Two Different States of Mouse Pluripotency. Ter Huurne M, Chappell J, Dalton S, Stunnenberg HG. Cell Stem Cell. 2017 Oct 5;21(4):449-455.e4. doi: 10.1016/j.stem.2017.09.004. PubMed
Phosphorylation of Threonine(343) Is Crucial for OCT4 Interaction with SOX2 in the Maintenance of Mouse Embryonic Stem Cell Pluripotency. Abulaiti X, Zhang H, Wang A, Li N, Li Y, Wang C, Du X, Li L. Stem Cell Reports. 2017 Nov 14;9(5):1630-1641. doi: 10.1016/j.stemcr.2017.09.001. Epub 2017 Oct 5. PubMed
A Ragulator-BORC interaction controls lysosome positioning in response to amino acid availability. Pu J, Keren-Kaplan T, Bonifacino JS. J Cell Biol. 2017 Dec 4;216(12):4183-4197. doi: 10.1083/jcb.201703094. Epub 2017 Oct 9. PubMed
CDK9-dependent RNA polymerase II pausing controls transcription initiation. Gressel S, Schwalb B, Decker TM, Qin W, Leonhardt H, Eick D, Cramer P. Elife. 2017 Oct 10;6. pii: 29736. doi: 10.7554/eLife.29736. PubMed
Gene Editing in Rat Embryonic Stem Cells to Produce In Vitro Models and In Vivo Reporters. Chen Y, Spitzer S, Agathou S, Karadottir RT, Smith A. Stem Cell Reports. 2017 Oct 10;9(4):1262-1274. doi: 10.1016/j.stemcr.2017.09.005. PubMed
A point mutation in the extracellular domain of CD4 completely abolishes CD4 T cell development in C57BL/6 mouse. Wang H, Li S, Chao T, Wang X, Shi L, Zhang L, Liang Y, Zheng Q, Lu L. Mol Immunol. 2017 Dec;92:12-20. doi: 10.1016/j.molimm.2017.09.015. Epub 2017 Oct 10. PubMed
Characterization and use of the novel human multiple myeloma cell line MC-B11/14 to study biological consequences of CRISPR-mediated loss of immunoglobulin A heavy chain. Walters DK, Arendt BK, Tschumper RC, Wu X, Jelinek DF. Exp Hematol. 2018 Jan;57:42-49.e1. doi: 10.1016/j.exphem.2017.09.010. Epub 2017 Oct 13. PubMed
Viperin Targets Flavivirus Virulence by Inducing Assembly of Noninfectious Capsid Particles. Vonderstein K, Nilsson E, Hubel P, Nygard Skalman L, Upadhyay A, Pasto J, Pichlmair A, Lundmark R, Overby AK. J Virol. 2017 Dec 14;92(1). pii: JVI.01751-17. doi: 10.1128/JVI.01751-17. Print 2018 Jan 1. PubMed
Characterization of gamma-tubulin filaments in mammalian cells. Lindstrom L, Alvarado-Kristensson M. Biochim Biophys Acta. 2017 Oct 16. pii: S0167-4889(17)30283-5. doi: 10.1016/j.bbamcr.2017.10.008. PubMed Associated Plasmids sg resistant gamma-tubulin gamma-tubulin (334-451) pSpCas9 (BB)-2A-GFP gamma-tubulin sg gamma-tubulin (1-335)
UNC-45a promotes myosin folding and stress fiber assembly. Lehtimaki JI, Fenix AM, Kotila TM, Balistreri G, Paavolainen L, Varjosalo M, Burnette DT, Lappalainen P. J Cell Biol. 2017 Dec 4;216(12):4053-4072. doi: 10.1083/jcb.201703107. Epub 2017 Oct 20. PubMed
PTEN Regulates PI(3,4)P2 Signaling Downstream of Class I PI3K. Malek M, Kielkowska A, Chessa T, Anderson KE, Barneda D, Pir P, Nakanishi H, Eguchi S, Koizumi A, Sasaki J, Juvin V, Kiselev VY, Niewczas I, Gray A, Valayer A, Spensberger D, Imbert M, Felisbino S, Habuchi T, Beinke S, Cosulich S, Le Novere N, Sasaki T, Clark J, Hawkins PT, Stephens LR. Mol Cell. 2017 Nov 2;68(3):566-580.e10. doi: 10.1016/j.molcel.2017.09.024. Epub 2017 Oct 19. PubMed
A cautionary tale of sense-antisense gene pairs: independent regulation despite inverse correlation of expression. Goyal A, Fiskin E, Gutschner T, Polycarpou-Schwarz M, Gross M, Neugebauer J, Gandhi M, Caudron-Herger M, Benes V, Diederichs S. Nucleic Acids Res. 2017 Dec 1;45(21):12496-12508. doi: 10.1093/nar/gkx952. PubMed
FANCI and FANCD2 have common as well as independent functions during the cellular replication stress response. Thompson EL, Yeo JE, Lee EA, Kan Y, Raghunandan M, Wiek C, Hanenberg H, Scharer OD, Hendrickson EA, Sobeck A. Nucleic Acids Res. 2017 Nov 16;45(20):11837-11857. doi: 10.1093/nar/gkx847. PubMed
From gRNA Identification to the Restoration of Dystrophin Expression: A Dystrophin Gene Correction Strategy for Duchenne Muscular Dystrophy Mutations Using the CRISPR-Induced Deletion Method. Duchene B, Iyombe-Engembe JP, Rousseau J, Tremblay JP, Ouellet DL. Methods Mol Biol. 2018;1687:267-283. doi: 10.1007/978-1-4939-7374-3_19. PubMed
Genome Editing of Erythroid Cell Culture Model Systems. Yik JJ, Crossley M, Quinlan KGR. Methods Mol Biol. 2018;1698:245-257. doi: 10.1007/978-1-4939-7428-3_15. PubMed
Mutational signatures of non-homologous and polymerase theta-mediated end-joining in embryonic stem cells. Schimmel J, Kool H, van Schendel R, Tijsterman M. EMBO J. 2017 Dec 15;36(24):3634-3649. doi: 10.15252/embj.201796948. Epub 2017 Oct 27. PubMed
miRNA independent hepacivirus variants suggest a strong evolutionary pressure to maintain miR-122 dependence. Yu Y, Scheel TKH, Luna JM, Chung H, Nishiuchi E, Scull MA, Echeverria N, Ricardo-Lax I, Kapoor A, Lipkin WI, Divers TJ, Antczak DF, Tennant BC, Rice CM. PLoS Pathog. 2017 Oct 30;13(10):e1006694. doi: 10.1371/journal.ppat.1006694. eCollection 2017 Oct. PubMed
IRAK4 is essential for TLR9-induced suppression of Epstein-Barr virus BZLF1 transcription in Akata Burkitt's lymphoma cells. Jordi M, Marty J, Mordasini V, Lunemann A, McComb S, Bernasconi M, Nadal D. PLoS One. 2017 Oct 31;12(10):e0186614. doi: 10.1371/journal.pone.0186614. eCollection 2017. PubMed
Widespread activation of antisense transcription of the host genome during herpes simplex virus 1 infection. Wyler E, Menegatti J, Franke V, Kocks C, Boltengagen A, Hennig T, Theil K, Rutkowski A, Ferrai C, Baer L, Kermas L, Friedel C, Rajewsky N, Akalin A, Dolken L, Grasser F, Landthaler M. Genome Biol. 2017 Oct 31;18(1):209. doi: 10.1186/s13059-017-1329-5. PubMed
An endosiRNA-Based Repression Mechanism Counteracts Transposon Activation during Global DNA Demethylation in Embryonic Stem Cells. Berrens RV, Andrews S, Spensberger D, Santos F, Dean W, Gould P, Sharif J, Olova N, Chandra T, Koseki H, von Meyenn F, Reik W. Cell Stem Cell. 2017 Nov 2;21(5):694-703.e7. doi: 10.1016/j.stem.2017.10.004. PubMed
Mutations in GREB1L Cause Bilateral Kidney Agenesis in Humans and Mice. De Tomasi L, David P, Humbert C, Silbermann F, Arrondel C, Tores F, Fouquet S, Desgrange A, Niel O, Bole-Feysot C, Nitschke P, Roume J, Cordier MP, Pietrement C, Isidor B, Khau Van Kien P, Gonzales M, Saint-Frison MH, Martinovic J, Novo R, Piard J, Cabrol C, Verma IC, Puri R, Journel H, Aziza J, Gavard L, Said-Menthon MH, Heidet L, Saunier S, Jeanpierre C. Am J Hum Genet. 2017 Nov 2;101(5):803-814. doi: 10.1016/j.ajhg.2017.09.026. PubMed
Pharmacoproteomic characterisation of human colon and rectal cancer. Frejno M, Zenezini Chiozzi R, Wilhelm M, Koch H, Zheng R, Klaeger S, Ruprecht B, Meng C, Kramer K, Jarzab A, Heinzlmeir S, Johnstone E, Domingo E, Kerr D, Jesinghaus M, Slotta-Huspenina J, Weichert W, Knapp S, Feller SM, Kuster B. Mol Syst Biol. 2017 Nov 3;13(11):951. doi: 10.15252/msb.20177701. PubMed
Angiopoietin-1 is required for Schlemm's canal development in mice and humans. Thomson BR, Souma T, Tompson SW, Onay T, Kizhatil K, Siggs OM, Feng L, Whisenhunt KN, Yanovitch TL, Kalaydjieva L, Azmanov DN, Finzi S, Tanna CE, Hewitt AW, Mackey DA, Bradfield YS, Souzeau E, Javadiyan S, Wiggs JL, Pasutto F, Liu X, John SW, Craig JE, Jin J, Young TL, Quaggin SE. J Clin Invest. 2017 Dec 1;127(12):4421-4436. doi: 10.1172/JCI95545. Epub 2017 Nov 6. PubMed
Differential requirement for ATG2A domains for localization to autophagic membranes and lipid droplets. Tamura N, Nishimura T, Sakamaki Y, Koyama-Honda I, Yamamoto H, Mizushima N. FEBS Lett. 2017 Dec;591(23):3819-3830. doi: 10.1002/1873-3468.12901. Epub 2017 Nov 20. PubMed Associated Plasmids pMRXIP-GFP-hATG2A
Monitoring of Dual CRISPR/Cas9-Mediated Steroidogenic Acute Regulatory Protein Gene Deletion and Cholesterol Accumulation Using High-Resolution Fluorescence In Situ Hybridization in a Single Cell. Lee J, Jefcoate C. Front Endocrinol (Lausanne). 2017 Oct 25;8:289. doi: 10.3389/fendo.2017.00289. eCollection 2017. PubMed
A Chemoproteomic Approach to Query the Degradable Kinome Using a Multi-kinase Degrader. Huang HT, Dobrovolsky D, Paulk J, Yang G, Weisberg EL, Doctor ZM, Buckley DL, Cho JH, Ko E, Jang J, Shi K, Choi HG, Griffin JD, Li Y, Treon SP, Fischer ES, Bradner JE, Tan L, Gray NS. Cell Chem Biol. 2018 Jan 18;25(1):88-99.e6. doi: 10.1016/j.chembiol.2017.10.005. Epub 2017 Nov 9. PubMed
A Transgenic Core Facility's Experience in Genome Editing Revolution. Yuan CL, Hu YC. Adv Exp Med Biol. 2017;1016:75-90. doi: 10.1007/978-3-319-63904-8_4. PubMed
Development of a genetic sensor that eliminates p53 deficient cells. Mircetic J, Dietrich A, Paszkowski-Rogacz M, Krause M, Buchholz F. Nat Commun. 2017 Nov 13;8(1):1463. doi: 10.1038/s41467-017-01688-w. PubMed
Fluorescently-tagged human eIF3 for single-molecule spectroscopy. Johnson AG, Petrov AN, Fuchs G, Majzoub K, Grosely R, Choi J, Puglisi JD. Nucleic Acids Res. 2018 Jan 25;46(2):e8. doi: 10.1093/nar/gkx1050. PubMed
Disrupting glucose-6-phosphate isomerase fully suppresses the "Warburg effect" and activates OXPHOS with minimal impact on tumor growth except in hypoxia. de Padua MC, Delodi G, Vucetic M, Durivault J, Vial V, Bayer P, Noleto GR, Mazure NM, Zdralevic M, Pouyssegur J. Oncotarget. 2017 Sep 18;8(50):87623-87637. doi: 10.18632/oncotarget.21007. eCollection 2017 Oct 20. PubMed
Galphai is required for carvedilol-induced beta1 adrenergic receptor beta-arrestin biased signaling. Wang J, Hanada K, Staus DP, Makara MA, Dahal GR, Chen Q, Ahles A, Engelhardt S, Rockman HA. Nat Commun. 2017 Nov 22;8(1):1706. doi: 10.1038/s41467-017-01855-z. PubMed
Novel inactivating mutations of the DCAF17 gene in American and Turkish families cause male infertility and female subfertility in the mouse model. Gurbuz F, Desai S, Diao F, Turkkahraman D, Wranitz F, Wood-Trageser M, Shin YH, Kotan LD, Jiang H, Witchel S, Gurtunca N, Yatsenko S, Mysliwec D, Topaloglu K, Rajkovic A. Clin Genet. 2018 Apr;93(4):853-859. doi: 10.1111/cge.13183. Epub 2018 Jan 24. PubMed
GSDME mediates caspase-3-dependent pyroptosis in gastric cancer. Wang Y, Yin B, Li D, Wang G, Han X, Sun X. Biochem Biophys Res Commun. 2018 Jan 1;495(1):1418-1425. doi: 10.1016/j.bbrc.2017.11.156. Epub 2017 Nov 26. PubMed
Repair of the TGFBI gene in human corneal keratocytes derived from a granular corneal dystrophy patient via CRISPR/Cas9-induced homology-directed repair. Taketani Y, Kitamoto K, Sakisaka T, Kimakura M, Toyono T, Yamagami S, Amano S, Kuroda M, Moore T, Usui T, Ouchi Y. Sci Rep. 2017 Dec 1;7(1):16713. doi: 10.1038/s41598-017-16308-2. PubMed
Polycomb subunit BMI1 determines uterine progesterone responsiveness essential for normal embryo implantation. Xin Q, Kong S, Yan J, Qiu J, He B, Zhou C, Ni Z, Bao H, Huang L, Lu J, Xia G, Liu X, Chen ZJ, Wang C, Wang H. J Clin Invest. 2018 Jan 2;128(1):175-189. doi: 10.1172/JCI92862. Epub 2017 Nov 20. PubMed
Versatile single-step-assembly CRISPR/Cas9 vectors for dual gRNA expression. Adikusuma F, Pfitzner C, Thomas PQ. PLoS One. 2017 Dec 6;12(12):e0187236. doi: 10.1371/journal.pone.0187236. eCollection 2017. PubMed Associated Plasmids pDG330 pDG335 pDG458 pDG459 pDG461 More ...
Novel Mutation in FLNC (Filamin C) Causes Familial Restrictive Cardiomyopathy. Tucker NR, McLellan MA, Hu D, Ye J, Parsons VA, Mills RW, Clauss S, Dolmatova E, Shea MA, Milan DJ, Scott NS, Lindsay M, Lubitz SA, Domian IJ, Stone JR, Lin H, Ellinor PT. Circ Cardiovasc Genet. 2017 Dec;10(6). pii: CIRCGENETICS.117.001780. doi: 10.1161/CIRCGENETICS.117.001780. PubMed
A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity. Sachs N, de Ligt J, Kopper O, Gogola E, Bounova G, Weeber F, Balgobind AV, Wind K, Gracanin A, Begthel H, Korving J, van Boxtel R, Duarte AA, Lelieveld D, van Hoeck A, Ernst RF, Blokzijl F, Nijman IJ, Hoogstraat M, van de Ven M, Egan DA, Zinzalla V, Moll J, Boj SF, Voest EE, Wessels L, van Diest PJ, Rottenberg S, Vries RGJ, Cuppen E, Clevers H. Cell. 2018 Jan 11;172(1-2):373-386.e10. doi: 10.1016/j.cell.2017.11.010. Epub 2017 Dec 7. PubMed
Mechanoactivation of the angiotensin II type 1 receptor induces beta-arrestin-biased signaling through Galphai coupling. Wang J, Hanada K, Gareri C, Rockman HA. J Cell Biochem. 2018 Apr;119(4):3586-3597. doi: 10.1002/jcb.26552. Epub 2018 Jan 4. PubMed
Ubiquitination Regulates the Proteasomal Degradation and Nuclear Translocation of the Fat Mass and Obesity-Associated (FTO) Protein. Zhu T, Yong XLH, Xia D, Widagdo J, Anggono V. J Mol Biol. 2018 Feb 2;430(3):363-371. doi: 10.1016/j.jmb.2017.12.003. Epub 2017 Dec 10. PubMed
Oncogenic Role of THOR, a Conserved Cancer/Testis Long Non-coding RNA. Hosono Y, Niknafs YS, Prensner JR, Iyer MK, Dhanasekaran SM, Mehra R, Pitchiaya S, Tien J, Escara-Wilke J, Poliakov A, Chu SC, Saleh S, Sankar K, Su F, Guo S, Qiao Y, Freier SM, Bui HH, Cao X, Malik R, Johnson TM, Beer DG, Feng FY, Zhou W, Chinnaiyan AM. Cell. 2017 Dec 14;171(7):1559-1572.e20. doi: 10.1016/j.cell.2017.11.040. PubMed
Digenic mutations on SCAP and AGXT2 predispose to premature myocardial infarction. Gao Y, Lee C, Song J, Li S, Cui Y, Liu Y, Wang J, Lu F, Chen H. Oncotarget. 2017 Oct 24;8(59):100141-100149. doi: 10.18632/oncotarget.22045. eCollection 2017 Nov 21. PubMed
Replication Stress Shapes a Protective Chromatin Environment across Fragile Genomic Regions. Kim J, Sturgill D, Sebastian R, Khurana S, Tran AD, Edwards GB, Kruswick A, Burkett S, Hosogane EK, Hannon WW, Weyemi U, Bonner WM, Luger K, Oberdoerffer P. Mol Cell. 2018 Jan 4;69(1):36-47.e7. doi: 10.1016/j.molcel.2017.11.021. Epub 2017 Dec 14. PubMed
Distinct SoxB1 networks are required for naive and primed pluripotency. Corsinotti A, Wong FC, Tatar T, Szczerbinska I, Halbritter F, Colby D, Gogolok S, Pantier R, Liggat K, Mirfazeli ES, Hall-Ponsele E, Mullin NP, Wilson V, Chambers I. Elife. 2017 Dec 19;6. pii: 27746. doi: 10.7554/eLife.27746. PubMed
Apoptosis induction and inhibition of HeLa cell proliferation by alpha-naphthoflavone and resveratrol are aryl hydrocarbon receptor-independent. Flores-Perez A, Elizondo G. Chem Biol Interact. 2018 Feb 1;281:98-105. doi: 10.1016/j.cbi.2017.12.029. Epub 2017 Dec 20. PubMed
CRISPR Screens Uncover Genes that Regulate Target Cell Sensitivity to the Morphogen Sonic Hedgehog. Pusapati GV, Kong JH, Patel BB, Krishnan A, Sagner A, Kinnebrew M, Briscoe J, Aravind L, Rohatgi R. Dev Cell. 2018 Jan 8;44(1):113-129.e8. doi: 10.1016/j.devcel.2017.12.003. Epub 2017 Dec 28. PubMed
The deubiquitinating enzyme cylindromatosis mitigates nonalcoholic steatohepatitis. Ji YX, Huang Z, Yang X, Wang X, Zhao LP, Wang PX, Zhang XJ, Alves-Bezerra M, Cai L, Zhang P, Lu YX, Bai L, Gao MM, Zhao H, Tian S, Wang Y, Huang ZX, Zhu XY, Zhang Y, Gong J, She ZG, Li F, Cohen DE, Li H. Nat Med. 2018 Feb;24(2):213-223. doi: 10.1038/nm.4461. Epub 2018 Jan 1. PubMed
Gene editing rescue of a novel MPL mutant associated with congenital amegakaryocytic thrombocytopenia. Cleyrat C, Girard R, Choi EH, Jeziorski E, Lavabre-Bertrand T, Hermouet S, Carillo S, Wilson BS. Blood Adv. 2017 Sep 22;1(21):1815-1826. doi: 10.1182/bloodadvances.2016002915. eCollection 2017 Sep 26. PubMed
Aldehyde dehydrogenase 1A3 (ALDH1A3) is regulated by autophagy in human glioblastoma cells. Wu W, Schecker J, Wurstle S, Schneider F, Schonfelder M, Schlegel J. Cancer Lett. 2018 Mar 28;417:112-123. doi: 10.1016/j.canlet.2017.12.036. Epub 2018 Jan 3. PubMed
Vps13D Encodes a Ubiquitin-Binding Protein that Is Required for the Regulation of Mitochondrial Size and Clearance. Anding AL, Wang C, Chang TK, Sliter DA, Powers CM, Hofmann K, Youle RJ, Baehrecke EH. Curr Biol. 2018 Jan 22;28(2):287-295.e6. doi: 10.1016/j.cub.2017.11.064. Epub 2018 Jan 4. PubMed
Scarless Genome Editing of Human Pluripotent Stem Cells via Transient Puromycin Selection. Steyer B, Bu Q, Cory E, Jiang K, Duong S, Sinha D, Steltzer S, Gamm D, Chang Q, Saha K. Stem Cell Reports. 2018 Feb 13;10(2):642-654. doi: 10.1016/j.stemcr.2017.12.004. Epub 2018 Jan 4. PubMed
The WD40 domain of ATG16L1 is required for its non-canonical role in lipidation of LC3 at single membranes. Fletcher K, Ulferts R, Jacquin E, Veith T, Gammoh N, Arasteh JM, Mayer U, Carding SR, Wileman T, Beale R, Florey O. EMBO J. 2018 Feb 15;37(4). pii: embj.201797840. doi: 10.15252/embj.201797840. Epub 2018 Jan 9. PubMed
The actin-MRTF-SRF transcriptional circuit controls tubulin acetylation via alpha-TAT1 gene expression. Fernandez-Barrera J, Bernabe-Rubio M, Casares-Arias J, Rangel L, Fernandez-Martin L, Correas I, Alonso MA. J Cell Biol. 2018 Mar 5;217(3):929-944. doi: 10.1083/jcb.201702157. Epub 2018 Jan 10. PubMed
The glutamine transporter ASCT2 (SLC1A5) promotes tumor growth independently of the amino acid transporter LAT1 (SLC7A5). Cormerais Y, Massard PA, Vucetic M, Giuliano S, Tambutte E, Durivault J, Vial V, Endou H, Wempe MF, Parks SK, Pouyssegur J. J Biol Chem. 2018 Feb 23;293(8):2877-2887. doi: 10.1074/jbc.RA117.001342. Epub 2018 Jan 11. PubMed
Human caspase-4 detects tetra-acylated LPS and cytosolic Francisella and functions differently from murine caspase-11. Lagrange B, Benaoudia S, Wallet P, Magnotti F, Provost A, Michal F, Martin A, Di Lorenzo F, Py BF, Molinaro A, Henry T. Nat Commun. 2018 Jan 16;9(1):242. doi: 10.1038/s41467-017-02682-y. PubMed
Constitutive centromere-associated network contacts confer differential stability on CENP-A nucleosomes in vitro and in the cell. Cao S, Zhou K, Zhang Z, Luger K, Straight AF. Mol Biol Cell. 2018 Mar 15;29(6):751-762. doi: 10.1091/mbc.E17-10-0596. Epub 2018 Jan 17. PubMed
Lack of beta-arrestin signaling in the absence of active G proteins. Grundmann M, Merten N, Malfacini D, Inoue A, Preis P, Simon K, Ruttiger N, Ziegler N, Benkel T, Schmitt NK, Ishida S, Muller I, Reher R, Kawakami K, Inoue A, Rick U, Kuhl T, Imhof D, Aoki J, Konig GM, Hoffmann C, Gomeza J, Wess J, Kostenis E. Nat Commun. 2018 Jan 23;9(1):341. doi: 10.1038/s41467-017-02661-3. PubMed
Large-scale image-based profiling of single-cell phenotypes in arrayed CRISPR-Cas9 gene perturbation screens. de Groot R, Luthi J, Lindsay H, Holtackers R, Pelkmans L. Mol Syst Biol. 2018 Jan 23;14(1):e8064. doi: 10.15252/msb.20178064. PubMed
Tissue-selective effects of nucleolar stress and rDNA damage in developmental disorders. Calo E, Gu B, Bowen ME, Aryan F, Zalc A, Liang J, Flynn RA, Swigut T, Chang HY, Attardi LD, Wysocka J. Nature. 2018 Feb 1;554(7690):112-117. doi: 10.1038/nature25449. Epub 2018 Jan 24. PubMed
Context-Dependent and Disease-Specific Diversity in Protein Interactions within Stress Granules. Markmiller S, Soltanieh S, Server KL, Mak R, Jin W, Fang MY, Luo EC, Krach F, Yang D, Sen A, Fulzele A, Wozniak JM, Gonzalez DJ, Kankel MW, Gao FB, Bennett EJ, Lecuyer E, Yeo GW. Cell. 2018 Jan 25;172(3):590-604.e13. doi: 10.1016/j.cell.2017.12.032. PubMed Associated Plasmids HR_G3BP1-V5-APEX2-GFP hPGK_V5-APEX2-GFP pLIX403_UBAP2L_mCherry pLIX403_deltaUBA_UBAP2L_mCherry
Molecular engineering of antibodies for site-specific covalent conjugation using CRISPR/Cas9. Khoshnejad M, Brenner JS, Motley W, Parhiz H, Greineder CF, Villa CH, Marcos-Contreras OA, Tsourkas A, Muzykantov VR. Sci Rep. 2018 Jan 29;8(1):1760. doi: 10.1038/s41598-018-19784-2. PubMed
Local control of intracellular microtubule dynamics by EB1 photodissociation. van Haren J, Charafeddine RA, Ettinger A, Wang H, Hahn KM, Wittmann T. Nat Cell Biol. 2018 Jan 29. pii: 10.1038/s41556-017-0028-5. doi: 10.1038/s41556-017-0028-5. PubMed Associated Plasmids pEB1N-LZ-LOV2(wt) pEB1N-LZ-LOV2(fast) pEB1N-LZ-mCherry-LOV2(wt) pmCherry-Zdk1-EB1C pEGFP-Zdk1-EB1C More ...
A novel cell line generated using the CRISPR/Cas9 technology as universal quality control material for KRAS G12V mutation testing. Jia S, Zhang R, Lin G, Peng R, Gao P, Han Y, Fu Y, Ding J, Wu Q, Zhang K, Xie J, Li J. J Clin Lab Anal. 2018 Jun;32(5):e22391. doi: 10.1002/jcla.22391. Epub 2018 Jan 30. PubMed
Generation of PTEN knockout bone marrow mesenchymal stem cell lines by CRISPR/Cas9-mediated genome editing. Shen Y, Zhang J, Yu T, Qi C. Cytotechnology. 2018 Apr;70(2):783-791. doi: 10.1007/s10616-017-0183-3. Epub 2018 Jan 31. PubMed
Correction of diverse muscular dystrophy mutations in human engineered heart muscle by single-site genome editing. Long C, Li H, Tiburcy M, Rodriguez-Caycedo C, Kyrychenko V, Zhou H, Zhang Y, Min YL, Shelton JM, Mammen PPA, Liaw NY, Zimmermann WH, Bassel-Duby R, Schneider JW, Olson EN. Sci Adv. 2018 Jan 31;4(1):eaap9004. doi: 10.1126/sciadv.aap9004. eCollection 2018 Jan. PubMed
Translational control of ERK signaling through miRNA/4EHP-directed silencing. Jafarnejad SM, Chapat C, Matta-Camacho E, Gelbart IA, Hesketh GG, Arguello M, Garzia A, Kim SH, Attig J, Shapiro M, Morita M, Khoutorsky A, Alain T, Gkogkas CG, Stern-Ginossar N, Tuschl T, Gingras AC, Duchaine TF, Sonenberg N. Elife. 2018 Feb 7;7. pii: 35034. doi: 10.7554/eLife.35034. PubMed
miR-195 targets cyclin D3 and survivin to modulate the tumorigenesis of non-small cell lung cancer. Yu X, Zhang Y, Cavazos D, Ma X, Zhao Z, Du L, Pertsemlidis A. Cell Death Dis. 2018 Feb 7;9(2):193. doi: 10.1038/s41419-017-0219-9. PubMed
Reactivating TP53 signaling by the novel MDM2 inhibitor DS-3032b as a therapeutic option for high-risk neuroblastoma. Arnhold V, Schmelz K, Proba J, Winkler A, Wunschel J, Toedling J, Deubzer HE, Kunkele A, Eggert A, Schulte JH, Hundsdoerfer P. Oncotarget. 2017 Dec 18;9(2):2304-2319. doi: 10.18632/oncotarget.23409. eCollection 2018 Jan 5. PubMed
The IAP family member BRUCE regulates autophagosome-lysosome fusion. Ebner P, Poetsch I, Deszcz L, Hoffmann T, Zuber J, Ikeda F. Nat Commun. 2018 Feb 9;9(1):599. doi: 10.1038/s41467-018-02823-x. PubMed
The TIA1 RNA-Binding Protein Family Regulates EIF2AK2-Mediated Stress Response and Cell Cycle Progression. Meyer C, Garzia A, Mazzola M, Gerstberger S, Molina H, Tuschl T. Mol Cell. 2018 Feb 15;69(4):622-635.e6. doi: 10.1016/j.molcel.2018.01.011. PubMed Associated Plasmids pENTR4_TIAL1 pFRT_TO_FlagHA_TIAL1 pFRT_TO_eGFP_TIAL1 pET28a_TIAL1 pFRT_TO_FlagHA_TIA1 More ...
RNA-Seq Analysis of IL-1B and IL-36 Responses in Epidermal Keratinocytes Identifies a Shared MyD88-Dependent Gene Signature. Swindell WR, Beamer MA, Sarkar MK, Loftus S, Fullmer J, Xing X, Ward NL, Tsoi LC, Kahlenberg MJ, Liang Y, Gudjonsson JE. Front Immunol. 2018 Jan 29;9:80. doi: 10.3389/fimmu.2018.00080. eCollection 2018. PubMed
Overlapping Role of SCYL1 and SCYL3 in Maintaining Motor Neuron Viability. Kuliyev E, Gingras S, Guy CS, Howell S, Vogel P, Pelletier S. J Neurosci. 2018 Feb 7. pii: JNEUROSCI.2282-17.2018. doi: 10.1523/JNEUROSCI.2282-17.2018. PubMed
Pgam5 released from damaged mitochondria induces mitochondrial biogenesis via Wnt signaling. Bernkopf DB, Jalal K, Bruckner M, Knaup KX, Gentzel M, Schambony A, Behrens J. J Cell Biol. 2018 Apr 2;217(4):1383-1394. doi: 10.1083/jcb.201708191. Epub 2018 Feb 8. PubMed
Dynamic EBF1 occupancy directs sequential epigenetic and transcriptional events in B-cell programming. Li R, Cauchy P, Ramamoorthy S, Boller S, Chavez L, Grosschedl R. Genes Dev. 2018 Jan 15;32(2):96-111. doi: 10.1101/gad.309583.117. Epub 2018 Feb 9. PubMed
Highly Efficient and Versatile Plasmid-Based Gene Editing in Primary T Cells. Kornete M, Marone R, Jeker LT. J Immunol. 2018 Feb 14. pii: jimmunol.1701121. doi: 10.4049/jimmunol.1701121. PubMed Associated Plasmids p242_LTJ_1kbCD45.1Template p248_LTJ_2kbCD45.1Template p243_LTJ_4kbCD45.1Template p249_LTJ_1kbFoxp3wtTemplate p250_LTJ_2kbFoxp3wtTemplate More ...
Actin retrograde flow controls natural killer cell response by regulating the conformation state of SHP-1. Matalon O, Ben-Shmuel A, Kivelevitz J, Sabag B, Fried S, Joseph N, Noy E, Biber G, Barda-Saad M. EMBO J. 2018 Mar 1;37(5). pii: embj.201696264. doi: 10.15252/embj.201696264. Epub 2018 Feb 15. PubMed
The exoribonuclease Xrn1 is a post-transcriptional negative regulator of autophagy. Delorme-Axford E, Abernathy E, Lennemann NJ, Bernard A, Ariosa A, Coyne CB, Kirkegaard K, Klionsky DJ. Autophagy. 2018;14(5):898-912. doi: 10.1080/15548627.2018.1441648. Epub 2018 Mar 21. PubMed
Intragenic origins due to short G1 phases underlie oncogene-induced DNA replication stress. Macheret M, Halazonetis TD. Nature. 2018 Mar 1;555(7694):112-116. doi: 10.1038/nature25507. Epub 2018 Feb 21. PubMed
BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis. McArthur K, Whitehead LW, Heddleston JM, Li L, Padman BS, Oorschot V, Geoghegan ND, Chappaz S, Davidson S, San Chin H, Lane RM, Dramicanin M, Saunders TL, Sugiana C, Lessene R, Osellame LD, Chew TL, Dewson G, Lazarou M, Ramm G, Lessene G, Ryan MT, Rogers KL, van Delft MF, Kile BT. Science. 2018 Feb 23;359(6378). pii: 359/6378/eaao6047. doi: 10.1126/science.aao6047. PubMed Associated Plasmids pMIH-TOMM20-Halo pMIH-mRuby2-BAK pMIH-mRuby2-BAX pMIH-TFAM-GFP
Recognition of RNA N(6)-methyladenosine by IGF2BP proteins enhances mRNA stability and translation. Huang H, Weng H, Sun W, Qin X, Shi H, Wu H, Zhao BS, Mesquita A, Liu C, Yuan CL, Hu YC, Huttelmaier S, Skibbe JR, Su R, Deng X, Dong L, Sun M, Li C, Nachtergaele S, Wang Y, Hu C, Ferchen K, Greis KD, Jiang X, Wei M, Qu L, Guan JL, He C, Yang J, Chen J. Nat Cell Biol. 2018 Mar;20(3):285-295. doi: 10.1038/s41556-018-0045-z. Epub 2018 Feb 23. PubMed
Delineation of the Exact Transcription Termination Signal for Type 3 Polymerase III. Gao Z, Herrera-Carrillo E, Berkhout B. Mol Ther Nucleic Acids. 2018 Mar 2;10:36-44. doi: 10.1016/j.omtn.2017.11.006. Epub 2017 Nov 21. PubMed
PARP14 Controls the Nuclear Accumulation of a Subset of Type I IFN-Inducible Proteins. Caprara G, Prosperini E, Piccolo V, Sigismondo G, Melacarne A, Cuomo A, Boothby M, Rescigno M, Bonaldi T, Natoli G. J Immunol. 2018 Apr 1;200(7):2439-2454. doi: 10.4049/jimmunol.1701117. Epub 2018 Mar 2. PubMed
Dissecting super-enhancer hierarchy based on chromatin interactions. Huang J, Li K, Cai W, Liu X, Zhang Y, Orkin SH, Xu J, Yuan GC. Nat Commun. 2018 Mar 5;9(1):943. doi: 10.1038/s41467-018-03279-9. PubMed
Unbiased compound-protein interface mapping and prediction of chemoresistance loci through forward genetics in haploid stem cells. Horn M, Kroef V, Allmeroth K, Schuller N, Miethe S, Peifer M, Penninger JM, Elling U, Denzel MS. Oncotarget. 2018 Jan 23;9(11):9838-9851. doi: 10.18632/oncotarget.24305. eCollection 2018 Feb 9. PubMed
Regulation of hepatic gluconeogenesis by nuclear factor Y transcription factor in mice. Zhang Y, Guan Q, Liu Y, Zhang Y, Chen Y, Chen J, Liu Y, Su Z. J Biol Chem. 2018 May 18;293(20):7894-7904. doi: 10.1074/jbc.RA117.000508. Epub 2018 Mar 12. PubMed
TRiC controls transcription resumption after UV damage by regulating Cockayne syndrome protein A. Pines A, Dijk M, Makowski M, Meulenbroek EM, Vrouwe MG, van der Weegen Y, Baltissen M, French PJ, van Royen ME, Luijsterburg MS, Mullenders LH, Vermeulen M, Vermeulen W, Pannu NS, van Attikum H. Nat Commun. 2018 Mar 12;9(1):1040. doi: 10.1038/s41467-018-03484-6. PubMed
GATA3 zinc finger 2 mutations reprogram the breast cancer transcriptional network. Takaku M, Grimm SA, Roberts JD, Chrysovergis K, Bennett BD, Myers P, Perera L, Tucker CJ, Perou CM, Wade PA. Nat Commun. 2018 Mar 13;9(1):1059. doi: 10.1038/s41467-018-03478-4. PubMed
Placentation defects are highly prevalent in embryonic lethal mouse mutants. Perez-Garcia V, Fineberg E, Wilson R, Murray A, Mazzeo CI, Tudor C, Sienerth A, White JK, Tuck E, Ryder EJ, Gleeson D, Siragher E, Wardle-Jones H, Staudt N, Wali N, Collins J, Geyer S, Busch-Nentwich EM, Galli A, Smith JC, Robertson E, Adams DJ, Weninger WJ, Mohun T, Hemberger M. Nature. 2018 Mar 22;555(7697):463-468. doi: 10.1038/nature26002. Epub 2018 Mar 14. PubMed
MUC16 overexpression induced by gene mutations promotes lung cancer cell growth and invasion. Kanwal M, Ding XJ, Song X, Zhou GB, Cao Y. Oncotarget. 2018 Jan 12;9(15):12226-12239. doi: 10.18632/oncotarget.24203. eCollection 2018 Feb 23. PubMed
4EHP-independent repression of endogenous mRNAs by the RNA-binding protein GIGYF2. Amaya Ramirez CC, Hubbe P, Mandel N, Bethune J. Nucleic Acids Res. 2018 Jun 20;46(11):5792-5808. doi: 10.1093/nar/gky198. PubMed
Site-specific O-glycosylation of members of the low-density lipoprotein receptor superfamily enhances ligand interactions. Wang S, Mao Y, Narimatsu Y, Ye Z, Tian W, Goth CK, Lira-Navarrete E, Pedersen NB, Benito-Vicente A, Martin C, Uribe KB, Hurtado-Guerrero R, Christoffersen C, Seidah NG, Nielsen R, Christensen EI, Hansen L, Bennett EP, Vakhrushev SY, Schjoldager KT, Clausen H. J Biol Chem. 2018 May 11;293(19):7408-7422. doi: 10.1074/jbc.M117.817981. Epub 2018 Mar 20. PubMed
H5N1 Influenza A Virus PB1-F2 Relieves HAX-1-Mediated Restriction of Avian Virus Polymerase PA in Human Lung Cells. Mazel-Sanchez B, Boal-Carvalho I, Silva F, Dijkman R, Schmolke M. J Virol. 2018 May 14;92(11). pii: JVI.00425-18. doi: 10.1128/JVI.00425-18. Print 2018 Jun 1. PubMed
An NF90/NF110-mediated feedback amplification loop regulates dicer expression and controls ovarian carcinoma progression. Barbier J, Chen X, Sanchez G, Cai M, Helsmoortel M, Higuchi T, Giraud P, Contreras X, Yuan G, Feng Z, Nait-Saidi R, Deas O, Bluy L, Judde JG, Rouquier S, Ritchie W, Sakamoto S, Xie D, Kiernan R. Cell Res. 2018 May;28(5):556-571. doi: 10.1038/s41422-018-0016-8. Epub 2018 Mar 21. PubMed
Deletion of MBD2 inhibits proliferation of chronic myeloid leukaemia blast phase cells. Cheng L, Tang Y, Chen X, Zhao L, Liu S, Ma Y, Wang N, Zhou K, Zhou J, Zhou M. Cancer Biol Ther. 2018 Aug 3;19(8):676-686. doi: 10.1080/15384047.2018.1450113. Epub 2018 Apr 19. PubMed
Mycobacterium tuberculosis Mce2E suppresses the macrophage innate immune response and promotes epithelial cell proliferation. Qiang L, Wang J, Zhang Y, Ge P, Chai Q, Li B, Shi Y, Zhang L, Gao GF, Liu CH. Cell Mol Immunol. 2018 Mar 23. pii: 10.1038/s41423-018-0016-0. doi: 10.1038/s41423-018-0016-0. PubMed
Infection with a Brazilian isolate of Zika virus generates RIG-I stimulatory RNA and the viral NS5 protein blocks type I IFN induction and signaling. Hertzog J, Dias Junior AG, Rigby RE, Donald CL, Mayer A, Sezgin E, Song C, Jin B, Hublitz P, Eggeling C, Kohl A, Rehwinkel J. Eur J Immunol. 2018 Mar 23. doi: 10.1002/eji.201847483. PubMed Associated Plasmids pX458_Ruby pcDNA3.2/Capsid pcDNA3.2/pr-Membrane pcDNA3.2/NS2A pcDNA3.2/NS2B More ...
Role for Wnt Signaling in Retinal Neuropil Development: Analysis via RNA-Seq and In Vivo Somatic CRISPR Mutagenesis. Sarin S, Zuniga-Sanchez E, Kurmangaliyev YZ, Cousins H, Patel M, Hernandez J, Zhang KX, Samuel MA, Morey M, Sanes JR, Zipursky SL. Neuron. 2018 Mar 22. pii: S0896-6273(18)30181-8. doi: 10.1016/j.neuron.2018.03.004. PubMed
PI4KIIalpha regulates insulin secretion and glucose homeostasis via a PKD-dependent pathway. Zhang L, Li J, Zhang P, Gao Z, Zhao Y, Qiao X, Chen C. Biophys Rep. 2018;4(1):25-38. doi: 10.1007/s41048-018-0049-z. Epub 2018 Mar 7. PubMed
Comparison of the editing patterns and editing efficiencies of TALEN and CRISPR-Cas9 when targeting the human CCR5 gene. Nerys-Junior A, Braga-Dias LP, Pezzuto P, Cotta-de-Almeida V, Tanuri A. Genet Mol Biol. 2018 Jan-Mar;41(1):167-179. doi: 10.1590/1678-4685-GMB-2017-0065. Epub 2018 Mar 19. PubMed
Loss of PTEN promotes formation of signaling-capable clathrin-coated pits. Rosselli-Murai LK, Yates JA, Yoshida S, Bourg J, Ho KKY, White M, Prisby J, Tan X, Altemus M, Bao L, Wu ZF, Veatch SL, Swanson JA, Merajver SD, Liu AP. J Cell Sci. 2018 Apr 26;131(8). pii: jcs.208926. doi: 10.1242/jcs.208926. PubMed
PGE2 mediates EGFR internalization and nuclear translocation via caveolin endocytosis promoting its transcriptional activity and proliferation in human NSCLC cells. Bazzani L, Donnini S, Giachetti A, Christofori G, Ziche M. Oncotarget. 2018 Feb 15;9(19):14939-14958. doi: 10.18632/oncotarget.24499. eCollection 2018 Mar 13. PubMed
Natural regulatory mutations elevate the fetal globin gene via disruption of BCL11A or ZBTB7A binding. Martyn GE, Wienert B, Yang L, Shah M, Norton LJ, Burdach J, Kurita R, Nakamura Y, Pearson RCM, Funnell APW, Quinlan KGR, Crossley M. Nat Genet. 2018 Apr;50(4):498-503. doi: 10.1038/s41588-018-0085-0. Epub 2018 Apr 2. PubMed
A Pan-Cancer Analysis of Enhancer Expression in Nearly 9000 Patient Samples. Chen H, Li C, Peng X, Zhou Z, Weinstein JN, Liang H. Cell. 2018 Apr 5;173(2):386-399.e12. doi: 10.1016/j.cell.2018.03.027. PubMed
Long non-coding RNA THOR promotes human osteosarcoma cell growth in vitro and in vivo. Chen W, Chen M, Xu Y, Chen X, Zhou P, Zhao X, Pang F, Liang W. Biochem Biophys Res Commun. 2018 May 23;499(4):913-919. doi: 10.1016/j.bbrc.2018.04.019. Epub 2018 Apr 9. PubMed
A Family of Vertebrate-Specific Polycombs Encoded by the LCOR/LCORL Genes Balance PRC2 Subtype Activities. Conway E, Jerman E, Healy E, Ito S, Holoch D, Oliviero G, Deevy O, Glancy E, Fitzpatrick DJ, Mucha M, Watson A, Rice AM, Chammas P, Huang C, Pratt-Kelly I, Koseki Y, Nakayama M, Ishikura T, Streubel G, Wynne K, Hokamp K, McLysaght A, Ciferri C, Di Croce L, Cagney G, Margueron R, Koseki H, Bracken AP. Mol Cell. 2018 May 3;70(3):408-421.e8. doi: 10.1016/j.molcel.2018.03.005. Epub 2018 Apr 5. PubMed Associated Plasmids pCR8 LCOR pCR8 PALI1 pCR8 JARID2 pLENTI EF1alpha FLAG/HA-LCOR pLENTI EF1alpha FLAG/HA-PALI1 More ...
An ADAM-10 dependent EPCR shedding links meningococcal interaction with endothelial cells to purpura fulminans. Lecuyer H, Virion Z, Barnier JP, Matczak S, Bourdoulous S, Bianchini E, Saller F, Borgel D, Nassif X, Coureuil M. PLoS Pathog. 2018 Apr 9;14(4):e1006981. doi: 10.1371/journal.ppat.1006981. eCollection 2018 Apr. PubMed
Identification of Prognostic Biomarkers by Combined mRNA and miRNA Expression Microarray Analysis in Pancreatic Cancer. Liu B, Yang H, Taher L, Denz A, Grutzmann R, Pilarsky C, Weber GF. Transl Oncol. 2018 Jun;11(3):700-714. doi: 10.1016/j.tranon.2018.03.003. Epub 2018 Apr 6. PubMed
NKX2-5 regulates human cardiomyogenesis via a HEY2 dependent transcriptional network. Anderson DJ, Kaplan DI, Bell KM, Koutsis K, Haynes JM, Mills RJ, Phelan DG, Qian EL, Leitoguinho AR, Arasaratnam D, Labonne T, Ng ES, Davis RP, Casini S, Passier R, Hudson JE, Porrello ER, Costa MW, Rafii A, Curl CL, Delbridge LM, Harvey RP, Oshlack A, Cheung MM, Mummery CL, Petrou S, Elefanty AG, Stanley EG, Elliott DA. Nat Commun. 2018 Apr 10;9(1):1373. doi: 10.1038/s41467-018-03714-x. PubMed
Meg3 Non-coding RNA Expression Controls Imprinting by Preventing Transcriptional Upregulation in cis. Sanli I, Lalevee S, Cammisa M, Perrin A, Rage F, Lleres D, Riccio A, Bertrand E, Feil R. Cell Rep. 2018 Apr 10;23(2):337-348. doi: 10.1016/j.celrep.2018.03.044. PubMed
Stable centrosomal roots disentangle to allow interphase centriole independence. Mahen R. PLoS Biol. 2018 Apr 12;16(4):e2003998. doi: 10.1371/journal.pbio.2003998. eCollection 2018 Apr. PubMed
CRMP2-Neurofibromin Interface Drives NF1-related Pain. Moutal A, Sun L, Yang X, Li W, Cai S, Luo S, Khanna R. Neuroscience. 2018 Jun 15;381:79-90. doi: 10.1016/j.neuroscience.2018.04.002. Epub 2018 Apr 12. PubMed
miR-195 potentiates the efficacy of microtubule-targeting agents in non-small cell lung cancer. Yu X, Zhang Y, Ma X, Pertsemlidis A. Cancer Lett. 2018 Jul 28;427:85-93. doi: 10.1016/j.canlet.2018.04.007. Epub 2018 Apr 13. PubMed
STAG2 deficiency induces interferon responses via cGAS-STING pathway and restricts virus infection. Ding S, Diep J, Feng N, Ren L, Li B, Ooi YS, Wang X, Brulois KF, Yasukawa LL, Li X, Kuo CJ, Solomon DA, Carette JE, Greenberg HB. Nat Commun. 2018 Apr 16;9(1):1485. doi: 10.1038/s41467-018-03782-z. PubMed
Pluripotency transcription factors and Tet1/2 maintain Brd4-independent stem cell identity. Finley LWS, Vardhana SA, Carey BW, Alonso-Curbelo D, Koche R, Chen Y, Wen D, King B, Radler MR, Rafii S, Lowe SW, Allis CD, Thompson CB. Nat Cell Biol. 2018 May;20(5):565-574. doi: 10.1038/s41556-018-0086-3. Epub 2018 Apr 16. PubMed
Continuous signaling of CD79b and CD19 is required for the fitness of Burkitt lymphoma B cells. He X, Klasener K, Iype JM, Becker M, Maity PC, Cavallari M, Nielsen PJ, Yang J, Reth M. EMBO J. 2018 Jun 1;37(11). pii: embj.201797980. doi: 10.15252/embj.201797980. Epub 2018 Apr 18. PubMed
IRS2 mutations linked to invasion in pleomorphic invasive lobular carcinoma. Zhu S, Ward BM, Yu J, Matthew-Onabanjo AN, Janusis J, Hsieh CC, Tomaszewicz K, Hutchinson L, Zhu LJ, Kandil D, Shaw LM. JCI Insight. 2018 Apr 19;3(8). pii: 97398. doi: 10.1172/jci.insight.97398. eCollection 2018 Apr 19. PubMed
Selection on the regulation of sympathetic nervous activity in humans and chimpanzees. Lee KS, Chatterjee P, Choi EY, Sung MK, Oh J, Won H, Park SM, Kim YJ, Yi SV, Choi JK. PLoS Genet. 2018 Apr 19;14(4):e1007311. doi: 10.1371/journal.pgen.1007311. eCollection 2018 Apr. PubMed
The atypical mitogen-activated protein kinase ERK3 is essential for establishment of epithelial architecture. Takahashi C, Miyatake K, Kusakabe M, Nishida E. J Biol Chem. 2018 Jun 1;293(22):8342-8361. doi: 10.1074/jbc.RA117.000992. Epub 2018 Apr 19. PubMed
Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)/CRISPR-Associated Endonuclease Cas9-Mediated Homology-Independent Integration for Generating Quality Control Materials for Clinical Molecular Genetic Testing. Lin G, Zhang K, Peng R, Han Y, Xie J, Li J. J Mol Diagn. 2018 May;20(3):373-380. doi: 10.1016/j.jmoldx.2018.02.002. PubMed
Enhanced Biosynthesis Performance of Heterologous Proteins in CHO-K1 Cells Using CRISPR-Cas9. Wang W, Zheng W, Hu F, He X, Wu D, Zhang W, Liu H, Ma X. ACS Synth Biol. 2018 May 18;7(5):1259-1268. doi: 10.1021/acssynbio.7b00375. Epub 2018 Apr 26. PubMed
Identification of a Novel Invasion-Promoting Region in Insulin Receptor Substrate 2. Mercado-Matos J, Janusis J, Zhu S, Chen SS, Shaw LM. Mol Cell Biol. 2018 Jun 28;38(14). pii: MCB.00590-17. doi: 10.1128/MCB.00590-17. Print 2018 Jul 15. PubMed
Smad proteins differentially regulate obesity-induced glucose and lipid abnormalities and inflammation via class-specific control of AMPK-related kinase MPK38/MELK activity. Seong HA, Manoharan R, Ha H. Cell Death Dis. 2018 May 1;9(5):471. doi: 10.1038/s41419-018-0489-x. PubMed
A-to-I RNA Editing Contributes to Proteomic Diversity in Cancer. Peng X, Xu X, Wang Y, Hawke DH, Yu S, Han L, Zhou Z, Mojumdar K, Jeong KJ, Labrie M, Tsang YH, Zhang M, Lu Y, Hwu P, Scott KL, Liang H, Mills GB. Cancer Cell. 2018 May 14;33(5):817-828.e7. doi: 10.1016/j.ccell.2018.03.026. Epub 2018 Apr 26. PubMed
Co-optation of Tandem DNA Repeats for the Maintenance of Mesenchymal Identity. Balestrieri C, Alfarano G, Milan M, Tosi V, Prosperini E, Nicoli P, Palamidessi A, Scita G, Diaferia GR, Natoli G. Cell. 2018 May 17;173(5):1150-1164.e14. doi: 10.1016/j.cell.2018.03.081. Epub 2018 Apr 26. PubMed
The GABAA Receptor beta Subunit Is Required for Inhibitory Transmission. Nguyen QA, Nicoll RA. Neuron. 2018 May 16;98(4):718-725.e3. doi: 10.1016/j.neuron.2018.03.046. Epub 2018 Apr 26. PubMed
High expression of Aurora-B is correlated with poor prognosis and drug resistance in non-small cell lung cancer. Yu J, Zhou J, Xu F, Bai W, Zhang W. Int J Biol Markers. 2018 May;33(2):215-221. doi: 10.1177/1724600817753098. Epub 2018 Apr 30. PubMed
Generation of a PAX6 knockout glioblastoma cell line with changes in cell cycle distribution and sensitivity to oxidative stress. Hegge B, Sjottem E, Mikkola I. BMC Cancer. 2018 May 2;18(1):496. doi: 10.1186/s12885-018-4394-6. PubMed
A mutation-led search for novel functional domains in MeCP2. Guy J, Alexander-Howden B, FitzPatrick L, DeSousa D, Koerner MV, Selfridge J, Bird A. Hum Mol Genet. 2018 Jul 15;27(14):2531-2545. doi: 10.1093/hmg/ddy159. PubMed
Long-term culture and cloning of primary human bronchial basal cells that maintain multipotent differentiation capacity and CFTR channel function. Peters-Hall JR, Coquelin ML, Torres MJ, LaRanger R, Alabi BR, Sho S, Calva-Moreno JF, Thomas PJ, Shay JW. Am J Physiol Lung Cell Mol Physiol. 2018 Aug 1;315(2):L313-L327. doi: 10.1152/ajplung.00355.2017. Epub 2018 May 3. PubMed
An optimized electroporation approach for efficient CRISPR/Cas9 genome editing in murine zygotes. Troder SE, Ebert LK, Butt L, Assenmacher S, Schermer B, Zevnik B. PLoS One. 2018 May 3;13(5):e0196891. doi: 10.1371/journal.pone.0196891. eCollection 2018. PubMed
An integrative model for alternative polyadenylation, IntMAP, delineates mTOR-modulated endoplasmic reticulum stress response. Chang JW, Zhang W, Yeh HS, Park M, Yao C, Shi Y, Kuang R, Yong J. Nucleic Acids Res. 2018 Jul 6;46(12):5996-6008. doi: 10.1093/nar/gky340. PubMed
Inhibition of PKCdelta reduces amyloid-beta levels and reverses Alzheimer disease phenotypes. Du Y, Zhao Y, Li C, Zheng Q, Tian J, Li Z, Huang TY, Zhang W, Xu H. J Exp Med. 2018 Jun 4;215(6):1665-1677. doi: 10.1084/jem.20171193. Epub 2018 May 8. PubMed
NOTCH-mediated non-cell autonomous regulation of chromatin structure during senescence. Parry AJ, Hoare M, Bihary D, Hansel-Hertsch R, Smith S, Tomimatsu K, Mannion E, Smith A, D'Santos P, Russell IA, Balasubramanian S, Kimura H, Samarajiwa SA, Narita M. Nat Commun. 2018 May 9;9(1):1840. doi: 10.1038/s41467-018-04283-9. PubMed
Identification of a transporter complex responsible for the cytosolic entry of nitrogen-containing bisphosphonates. Yu Z, Surface LE, Park CY, Horlbeck MA, Wyant GA, Abu-Remaileh M, Peterson TR, Sabatini DM, Weissman JS, O'Shea EK. Elife. 2018 May 10;7. pii: 36620. doi: 10.7554/eLife.36620. PubMed
CD4(+) T-cell-Mediated Rejection of MHC Class II-Positive Tumor Cells Is Dependent on Antigen Secretion and Indirect Presentation on Host APCs. Haabeth OAW, Fauskanger M, Manzke M, Lundin KU, Corthay A, Bogen B, Tveita AA. Cancer Res. 2018 Aug 15;78(16):4573-4585. doi: 10.1158/0008-5472.CAN-17-2426. Epub 2018 May 11. PubMed
Importance of Validating Antibodies and Small Compound Inhibitors Using Genetic Knockout Studies-T Cell Receptor-Induced CYLD Phosphorylation by IKKepsilon/TBK1 as a Case Study. Lork M, Kreike M, Staal J, Beyaert R. Front Cell Dev Biol. 2018 Apr 10;6:40. doi: 10.3389/fcell.2018.00040. eCollection 2018. PubMed
Tumor-associated calreticulin variants functionally compromise the peptide loading complex and impair its recruitment of MHC-I. Arshad N, Cresswell P. J Biol Chem. 2018 Jun 22;293(25):9555-9569. doi: 10.1074/jbc.RA118.002836. Epub 2018 May 16. PubMed
HIV-1 Activation of Innate Immunity Depends Strongly on the Intracellular Level of TREX1 and Sensing of Incomplete Reverse Transcription Products. Kumar S, Morrison JH, Dingli D, Poeschla E. J Virol. 2018 Jul 31;92(16). pii: JVI.00001-18. doi: 10.1128/JVI.00001-18. Print 2018 Aug 15. PubMed
The orphan G-protein-coupled receptor 75 signaling is activated by the chemokine CCL5. Dedoni S, Campbell LA, Harvey BK, Avdoshina V, Mocchetti I. J Neurochem. 2018 Sep;146(5):526-539. doi: 10.1111/jnc.14463. Epub 2018 Aug 2. PubMed
Autophagosomal YKT6 is required for fusion with lysosomes independently of syntaxin 17. Matsui T, Jiang P, Nakano S, Sakamaki Y, Yamamoto H, Mizushima N. J Cell Biol. 2018 Aug 6;217(8):2633-2645. doi: 10.1083/jcb.201712058. Epub 2018 May 22. PubMed Associated Plasmids pMRXIP-Myc-SNAP29 pMRXIP-Myc-YKT6 pMRXIP-GFP-YKT6
Fast-Evolving Human-Specific Neural Enhancers Are Associated with Aging-Related Diseases. Chen H, Li C, Zhou Z, Liang H. Cell Syst. 2018 May 23;6(5):604-611.e4. doi: 10.1016/j.cels.2018.04.002. PubMed
The genomic landscape of TERT promoter wildtype-IDH wildtype glioblastoma. Diplas BH, He X, Brosnan-Cashman JA, Liu H, Chen LH, Wang Z, Moure CJ, Killela PJ, Loriaux DB, Lipp ES, Greer PK, Yang R, Rizzo AJ, Rodriguez FJ, Friedman AH, Friedman HS, Wang S, He Y, McLendon RE, Bigner DD, Jiao Y, Waitkus MS, Meeker AK, Yan H. Nat Commun. 2018 May 25;9(1):2087. doi: 10.1038/s41467-018-04448-6. PubMed
CRISPR-Based Targeted Epigenetic Editing Enables Gene Expression Modulation of the Silenced Beta-Galactoside Alpha-2,6-Sialyltransferase 1 in CHO Cells. Marx N, Grunwald-Gruber C, Bydlinski N, Dhiman H, Ngoc Nguyen L, Klanert G, Borth N. Biotechnol J. 2018 Oct;13(10):e1700217. doi: 10.1002/biot.201700217. Epub 2018 Jun 11. PubMed
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The Tumor Suppressor CIC Directly Regulates MAPK Pathway Genes via Histone Deacetylation. Weissmann S, Cloos PA, Sidoli S, Jensen ON, Pollard S, Helin K. Cancer Res. 2018 Aug 1;78(15):4114-4125. doi: 10.1158/0008-5472.CAN-18-0342. Epub 2018 May 29. PubMed
Amino Acid Variation at VP1-145 of Enterovirus 71 Determines Attachment Receptor Usage and Neurovirulence in Human Scavenger Receptor B2 Transgenic Mice. Kobayashi K, Sudaka Y, Takashino A, Imura A, Fujii K, Koike S. J Virol. 2018 Jul 17;92(15). pii: JVI.00681-18. doi: 10.1128/JVI.00681-18. Print 2018 Aug 1. PubMed
Retrograde transport of gamma-secretase from endosomes to the trans-Golgi network regulates Abeta42 production. Kanatsu K, Hori Y, Ebinuma I, Chiu YW, Tomita T. J Neurochem. 2018 Oct;147(1):110-123. doi: 10.1111/jnc.14477. Epub 2018 Aug 16. PubMed
A CRISPR/Cas9 based engineering strategy for overexpression of multiple genes in Chinese hamster ovary cells. Eisenhut P, Klanert G, Weinguny M, Baier L, Jadhav V, Ivansson D, Borth N. Metab Eng. 2018 Jul;48:72-81. doi: 10.1016/j.ymben.2018.05.017. Epub 2018 May 28. PubMed
In vivo RNAi screening identifies Pafah1b3 as a target for combination therapy with TKIs in BCR-ABL1(+) BCP-ALL. Fiedler ERC, Bhutkar A, Lawler E, Besada R, Hemann MT. Blood Adv. 2018 Jun 12;2(11):1229-1242. doi: 10.1182/bloodadvances.2017015610. PubMed
Human-Specific NOTCH2NL Genes Affect Notch Signaling and Cortical Neurogenesis. Fiddes IT, Lodewijk GA, Mooring M, Bosworth CM, Ewing AD, Mantalas GL, Novak AM, van den Bout A, Bishara A, Rosenkrantz JL, Lorig-Roach R, Field AR, Haeussler M, Russo L, Bhaduri A, Nowakowski TJ, Pollen AA, Dougherty ML, Nuttle X, Addor MC, Zwolinski S, Katzman S, Kriegstein A, Eichler EE, Salama SR, Jacobs FMJ, Haussler D. Cell. 2018 May 31;173(6):1356-1369.e22. doi: 10.1016/j.cell.2018.03.051. Epub 2018 May 31. PubMed
CRISPR/Cas9 Mediated Disruption of the Swedish APP Allele as a Therapeutic Approach for Early-Onset Alzheimer's Disease. Gyorgy B, Loov C, Zaborowski MP, Takeda S, Kleinstiver BP, Commins C, Kastanenka K, Mu D, Volak A, Giedraitis V, Lannfelt L, Maguire CA, Joung JK, Hyman BT, Breakefield XO, Ingelsson M. Mol Ther Nucleic Acids. 2018 Jun 1;11:429-440. doi: 10.1016/j.omtn.2018.03.007. Epub 2018 Mar 16. PubMed
Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR. Walton ZE, Patel CH, Brooks RC, Yu Y, Ibrahim-Hashim A, Riddle M, Porcu A, Jiang T, Ecker BL, Tameire F, Koumenis C, Weeraratna AT, Welsh DK, Gillies R, Alwine JC, Zhang L, Powell JD, Dang CV. Cell. 2018 Jun 28;174(1):72-87.e32. doi: 10.1016/j.cell.2018.05.009. Epub 2018 May 31. PubMed Associated Plasmids pGL4.22-PGK1-HRE::dLUC pGL4.22-VEGF-HRE::dLUC PX458-sgEIF4EBP1 PX458-sgTSC2 pcDNA3.1+ Flag-RAP2A More ...
APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer's Disease Phenotypes in Human iPSC-Derived Brain Cell Types. Lin YT, Seo J, Gao F, Feldman HM, Wen HL, Penney J, Cam HP, Gjoneska E, Raja WK, Cheng J, Rueda R, Kritskiy O, Abdurrob F, Peng Z, Milo B, Yu CJ, Elmsaouri S, Dey D, Ko T, Yankner BA, Tsai LH. Neuron. 2018 Jun 27;98(6):1141-1154.e7. doi: 10.1016/j.neuron.2018.05.008. Epub 2018 May 31. PubMed
A Modified Monomeric Red Fluorescent Protein Reporter for Assessing CRISPR Activity. Hojland Knudsen C, Asgrimsdottir ES, Rahimi K, Gill KP, Frandsen S, Hvolbol Buchholdt S, Chen M, Kjems J, Febbraro F, Denham M. Front Cell Dev Biol. 2018 May 15;6:54. doi: 10.3389/fcell.2018.00054. eCollection 2018. PubMed Associated Plasmids pGEmCherry2 hAAVS1-gs4_EF1a-Cas9-2A-GFP pCAG-SpCas9-2A-GFP-noITR LentiCRISPRv2-sgSORCS2-G2
Deficient ganglioside synthesis restores responsiveness to leptin and melanocortin signaling in obese KKAy mice. Inamori KI, Ito H, Tamura Y, Nitta T, Yang X, Nihei W, Shishido F, Imazu S, Tsukita S, Yamada T, Katagiri H, Inokuchi JI. J Lipid Res. 2018 Aug;59(8):1472-1481. doi: 10.1194/jlr.M085753. Epub 2018 Jun 7. PubMed
MLKL Requires the Inositol Phosphate Code to Execute Necroptosis. Dovey CM, Diep J, Clarke BP, Hale AT, McNamara DE, Guo H, Brown NW Jr, Cao JY, Grace CR, Gough PJ, Bertin J, Dixon SJ, Fiedler D, Mocarski ES, Kaiser WJ, Moldoveanu T, York JD, Carette JE. Mol Cell. 2018 Jun 7;70(5):936-948.e7. doi: 10.1016/j.molcel.2018.05.010. Epub 2018 Jun 7. PubMed
Speed genome editing by transient CRISPR/Cas9 targeting and large DNA fragment deletion. Luo J, Lu L, Gu Y, Huang R, Gui L, Li S, Qi X, Zheng W, Chao T, Zheng Q, Liang Y, Zhang L. J Biotechnol. 2018 Jun 7;281:11-20. doi: 10.1016/j.jbiotec.2018.06.308. PubMed Associated Plasmids pX458-DsRed2 pX458-ECFP
A Flat BAR Protein Promotes Actin Polymerization at the Base of Clathrin-Coated Pits. Almeida-Souza L, Frank RAW, Garcia-Nafria J, Colussi A, Gunawardana N, Johnson CM, Yu M, Howard G, Andrews B, Vallis Y, McMahon HT. Cell. 2018 Jul 12;174(2):325-337.e14. doi: 10.1016/j.cell.2018.05.020. Epub 2018 Jun 7. PubMed
Using CRISPR/Cas9 to Knock out Amylase in Acinar Cells Decreases Pancreatitis-Induced Autophagy. Yasunaga K, Ito T, Miki M, Ueda K, Fujiyama T, Tachibana Y, Fujimori N, Kawabe K, Ogawa Y. Biomed Res Int. 2018 May 17;2018:8719397. doi: 10.1155/2018/8719397. eCollection 2018. PubMed
Dual role of USP30 in controlling basal pexophagy and mitophagy. Marcassa E, Kallinos A, Jardine J, Rusilowicz-Jones EV, Martinez A, Kuehl S, Islinger M, Clague MJ, Urbe S. EMBO Rep. 2018 Jul;19(7). pii: embr.201745595. doi: 10.15252/embr.201745595. Epub 2018 Jun 12. PubMed
Alleviation of reactive oxygen species enhances PUFA accumulation in Schizochytrium sp. through regulating genes involved in lipid metabolism. Zhang S, He Y, Sen B, Chen X, Xie Y, Keasling JD, Wang G. Metab Eng Commun. 2018 Mar 27;6:39-48. doi: 10.1016/j.meteno.2018.03.002. eCollection 2018 Jun. PubMed
Disruption of a -35 kb Enhancer Impairs CTCF Binding and MLH1 Expression in Colorectal Cells. Liu Q, Thoms JAI, Nunez AC, Huang Y, Knezevic K, Packham D, Poulos RC, Williams R, Beck D, Hawkins NJ, Ward RL, Wong JWH, Hesson LB, Sloane MA, Pimanda JE. Clin Cancer Res. 2018 Sep 15;24(18):4602-4611. doi: 10.1158/1078-0432.CCR-17-3678. Epub 2018 Jun 13. PubMed
Dual Requirement of CHD8 for Chromatin Landscape Establishment and Histone Methyltransferase Recruitment to Promote CNS Myelination and Repair. Zhao C, Dong C, Frah M, Deng Y, Marie C, Zhang F, Xu L, Ma Z, Dong X, Lin Y, Koenig S, Nait-Oumesmar B, Martin DM, Wu LN, Xin M, Zhou W, Parras C, Lu QR. Dev Cell. 2018 Jun 18;45(6):753-768.e8. doi: 10.1016/j.devcel.2018.05.022. PubMed
Capturing the Onset of PRC2-Mediated Repressive Domain Formation. Oksuz O, Narendra V, Lee CH, Descostes N, LeRoy G, Raviram R, Blumenberg L, Karch K, Rocha PP, Garcia BA, Skok JA, Reinberg D. Mol Cell. 2018 Jun 21;70(6):1149-1162.e5. doi: 10.1016/j.molcel.2018.05.023. PubMed Associated Plasmids EED-KO-gRNA-1 EED-KO-gRNA-2 Y365A or A365Y inducible rescue A365Y-GFP Donor for iWTr EED Y365A-GFP Donor for iMTr EED More ...
AT 101 induces early mitochondrial dysfunction and HMOX1 (heme oxygenase 1) to trigger mitophagic cell death in glioma cells. Meyer N, Zielke S, Michaelis JB, Linder B, Warnsmann V, Rakel S, Osiewacz HD, Fulda S, Mittelbronn M, Munch C, Behrends C, Kogel D. Autophagy. 2018;14(10):1693-1709. doi: 10.1080/15548627.2018.1476812. Epub 2018 Jul 21. PubMed
Novel combined Ato-C treatment synergistically suppresses proliferation of Bcr-Abl-positive leukemic cells in vitro and in vivo. Wahiduzzaman M, Ota A, Karnan S, Hanamura I, Mizuno S, Kanasugi J, Rahman ML, Hyodo T, Konishi H, Tsuzuki S, Takami A, Hosokawa Y. Cancer Lett. 2018 Oct 1;433:117-130. doi: 10.1016/j.canlet.2018.06.027. Epub 2018 Jun 23. PubMed
The Effect of GPRC5a on the Proliferation, Migration Ability, Chemotherapy Resistance, and Phosphorylation of GSK-3beta in Pancreatic Cancer. Liu B, Yang H, Pilarsky C, Weber GF. Int J Mol Sci. 2018 Jun 26;19(7). pii: ijms19071870. doi: 10.3390/ijms19071870. PubMed
Induction of innate immune memory via microRNA targeting of chromatin remodelling factors. Seeley JJ, Baker RG, Mohamed G, Bruns T, Hayden MS, Deshmukh SD, Freedberg DE, Ghosh S. Nature. 2018 Jul;559(7712):114-119. doi: 10.1038/s41586-018-0253-5. Epub 2018 Jun 27. PubMed
Evolution of Cortical Neurogenesis in Amniotes Controlled by Robo Signaling Levels. Cardenas A, Villalba A, de Juan Romero C, Pico E, Kyrousi C, Tzika AC, Tessier-Lavigne M, Ma L, Drukker M, Cappello S, Borrell V. Cell. 2018 Jul 26;174(3):590-606.e21. doi: 10.1016/j.cell.2018.06.007. Epub 2018 Jun 28. PubMed
The Cytotoxicity of Epsilon Toxin from Clostridium perfringens on Lymphocytes Is Mediated by MAL Protein Expression. Blanch M, Dorca-Arevalo J, Not A, Cases M, Gomez de Aranda I, Martinez-Yelamos A, Martinez-Yelamos S, Solsona C, Blasi J. Mol Cell Biol. 2018 Sep 14;38(19). pii: MCB.00086-18. doi: 10.1128/MCB.00086-18. Print 2018 Oct 1. PubMed
Cryo-EM structures of fungal and metazoan mitochondrial calcium uniporters. Baradaran R, Wang C, Siliciano AF, Long SB. Nature. 2018 Jul;559(7715):580-584. doi: 10.1038/s41586-018-0331-8. Epub 2018 Jul 11. PubMed
Cleavage of Toll-Like Receptor 9 Ectodomain Is Required for In Vivo Responses to Single Strand DNA. Fukui R, Yamamoto C, Matsumoto F, Onji M, Shibata T, Murakami Y, Kanno A, Hayashi T, Tanimura N, Yoshida N, Miyake K. Front Immunol. 2018 Jun 27;9:1491. doi: 10.3389/fimmu.2018.01491. eCollection 2018. PubMed
DDX3 suppresses type I interferons and favors viral replication during Arenavirus infection. Loureiro ME, Zorzetto-Fernandes AL, Radoshitzky S, Chi X, Dallari S, Marooki N, Leger P, Foscaldi S, Harjono V, Sharma S, Zid BM, Lopez N, de la Torre JC, Bavari S, Zuniga E. PLoS Pathog. 2018 Jul 12;14(7):e1007125. doi: 10.1371/journal.ppat.1007125. eCollection 2018 Jul. PubMed
DNA Replication Determines Timing of Mitosis by Restricting CDK1 and PLK1 Activation. Lemmens B, Hegarat N, Akopyan K, Sala-Gaston J, Bartek J, Hochegger H, Lindqvist A. Mol Cell. 2018 Jul 5;71(1):117-128.e3. doi: 10.1016/j.molcel.2018.05.026. Epub 2018 Jun 28. PubMed
In vitro-transcribed guide RNAs trigger an innate immune response via the RIG-I pathway. Wienert B, Shin J, Zelin E, Pestal K, Corn JE. PLoS Biol. 2018 Jul 16;16(7):e2005840. doi: 10.1371/journal.pbio.2005840. eCollection 2018 Jul. PubMed
GRHL2-Dependent Enhancer Switching Maintains a Pluripotent Stem Cell Transcriptional Subnetwork after Exit from Naive Pluripotency. Chen AF, Liu AJ, Krishnakumar R, Freimer JW, DeVeale B, Blelloch R. Cell Stem Cell. 2018 Aug 2;23(2):226-238.e4. doi: 10.1016/j.stem.2018.06.005. Epub 2018 Jul 12. PubMed
The contributions of individual galactosyltransferases to protein specific N-glycan processing in Chinese Hamster Ovary cells. Bydlinski N, Maresch D, Schmieder V, Klanert G, Strasser R, Borth N. J Biotechnol. 2018 Sep 20;282:101-110. doi: 10.1016/j.jbiotec.2018.07.015. Epub 2018 Jul 11. PubMed
Photosensitivity and type I IFN responses in cutaneous lupus are driven by epidermal-derived interferon kappa. Sarkar MK, Hile GA, Tsoi LC, Xing X, Liu J, Liang Y, Berthier CC, Swindell WR, Patrick MT, Shao S, Tsou PS, Uppala R, Beamer MA, Srivastava A, Bielas SL, Harms PW, Getsios S, Elder JT, Voorhees JJ, Gudjonsson JE, Kahlenberg JM. Ann Rheum Dis. 2018 Nov;77(11):1653-1664. doi: 10.1136/annrheumdis-2018-213197. Epub 2018 Jul 18. PubMed
Mutations in microRNA processing genes in Wilms tumors derepress the IGF2 regulator PLAG1. Chen KS, Stroup EK, Budhipramono A, Rakheja D, Nichols-Vinueza D, Xu L, Stuart SH, Shukla AA, Fraire C, Mendell JT, Amatruda JF. Genes Dev. 2018 Aug 1;32(15-16):996-1007. doi: 10.1101/gad.313783.118. Epub 2018 Jul 19. PubMed Associated Plasmids pLXC2B-PLAG1-3xFLAG
Translational Control through Differential Ribosome Pausing during Amino Acid Limitation in Mammalian Cells. Darnell AM, Subramaniam AR, O'Shea EK. Mol Cell. 2018 Jul 19;71(2):229-243.e11. doi: 10.1016/j.molcel.2018.06.041. PubMed
A Simple Bioreactor-Based Method to Generate Kidney Organoids from Pluripotent Stem Cells. Przepiorski A, Sander V, Tran T, Hollywood JA, Sorrenson B, Shih JH, Wolvetang EJ, McMahon AP, Holm TM, Davidson AJ. Stem Cell Reports. 2018 Aug 14;11(2):470-484. doi: 10.1016/j.stemcr.2018.06.018. Epub 2018 Jul 19. PubMed
CRISPR/Cas9 nickase mediated targeting of urokinase receptor gene inhibits neuroblastoma cell proliferation. Rysenkova KD, Semina EV, Karagyaur MN, Shmakova AA, Dyikanov DT, Vasiluev PA, Rubtsov YP, Rubina KA, Tkachuk VA. Oncotarget. 2018 Jun 29;9(50):29414-29430. doi: 10.18632/oncotarget.25647. eCollection 2018 Jun 29. PubMed
Single olfactory receptors set odor detection thresholds. Dewan A, Cichy A, Zhang J, Miguel K, Feinstein P, Rinberg D, Bozza T. Nat Commun. 2018 Jul 23;9(1):2887. doi: 10.1038/s41467-018-05129-0. PubMed
Local chromatin interactions contribute to expression of the fibrinogen gene cluster. Espitia Jaimes C, Fish RJ, Neerman-Arbez M. J Thromb Haemost. 2018 Oct;16(10):2070-2082. doi: 10.1111/jth.14248. Epub 2018 Aug 23. PubMed
Measuring NDC80 binding reveals the molecular basis of tension-dependent kinetochore-microtubule attachments. Yoo TY, Choi JM, Conway W, Yu CH, Pappu RV, Needleman DJ. Elife. 2018 Jul 25;7. pii: 36392. doi: 10.7554/eLife.36392. PubMed Associated Plasmids pJAG98-mTurquoise2-Nuf2 pBABE-puro-mTurquoise2-Nuf2 pBABE-hygro-mTurquoise2-Nuf2 pTY07 pJAG98-mTurquoise2-FHA2-AURKB substrate-YPet
Decoupling the impact of microRNAs on translational repression versus RNA degradation in embryonic stem cells. Freimer JW, Hu TJ, Blelloch R. Elife. 2018 Jul 25;7. pii: 38014. doi: 10.7554/eLife.38014. PubMed
Site-1 protease deficiency causes human skeletal dysplasia due to defective inter-organelle protein trafficking. Kondo Y, Fu J, Wang H, Hoover C, McDaniel JM, Steet R, Patra D, Song J, Pollard L, Cathey S, Yago T, Wiley G, Macwana S, Guthridge J, McGee S, Li S, Griffin C, Furukawa K, James JA, Ruan C, McEver RP, Wierenga KJ, Gaffney PM, Xia L. JCI Insight. 2018 Jul 26;3(14). pii: 121596. doi: 10.1172/jci.insight.121596. eCollection 2018 Jul 26. PubMed
Widespread anti-CRISPR proteins in virulent bacteriophages inhibit a range of Cas9 proteins. Hynes AP, Rousseau GM, Agudelo D, Goulet A, Amigues B, Loehr J, Romero DA, Fremaux C, Horvath P, Doyon Y, Cambillau C, Moineau S. Nat Commun. 2018 Jul 25;9(1):2919. doi: 10.1038/s41467-018-05092-w. PubMed Associated Plasmids pVAX_CBI_AcrIIA2 pVAX_CBI_AcrIIA4 pVAX_CBI_AcrIIA5_D1126 pVAX_CBI_AcrIIA5_D4276 pVAX_CBI_AcrIIA6_D1024 More ...
53BP1 cooperation with the REV7-shieldin complex underpins DNA structure-specific NHEJ. Ghezraoui H, Oliveira C, Becker JR, Bilham K, Moralli D, Anzilotti C, Fischer R, Deobagkar-Lele M, Sanchiz-Calvo M, Fueyo-Marcos E, Bonham S, Kessler BM, Rottenberg S, Cornall RJ, Green CM, Chapman JR. Nature. 2018 Aug;560(7716):122-127. doi: 10.1038/s41586-018-0362-1. Epub 2018 Jul 25. PubMed
miR-122, small RNA annealing and sequence mutations alter the predicted structure of the Hepatitis C virus 5' UTR RNA to stabilize and promote viral RNA accumulation. Amador-Canizares Y, Panigrahi M, Huys A, Kunden RD, Adams HM, Schinold MJ, Wilson JA. Nucleic Acids Res. 2018 Oct 12;46(18):9776-9792. doi: 10.1093/nar/gky662. PubMed
Trafficking of cholesterol to the ER is required for NLRP3 inflammasome activation. de la Roche M, Hamilton C, Mortensen R, Jeyaprakash AA, Ghosh S, Anand PK. J Cell Biol. 2018 Oct 1;217(10):3560-3576. doi: 10.1083/jcb.201709057. Epub 2018 Jul 27. PubMed
Systematic perturbation of retroviral LTRs reveals widespread long-range effects on human gene regulation. Fuentes DR, Swigut T, Wysocka J. Elife. 2018 Aug 2;7. pii: 35989. doi: 10.7554/eLife.35989. PubMed Associated Plasmids PiggyBac dCas9-VPR PiggyBac dCas9-KRAB LTR5HS S. pyogenes scaffold CARGO array LTR5HS S. aureus scaffold CARGO array nontarget S. pyogenes scaffold CARGO array
CRISPR/Cas9 Gene Editing of Human Histone H2A Variant H2AX and MacroH2A. Leung JWC, Emery LE, Miller KM. Methods Mol Biol. 2018;1832:255-269. doi: 10.1007/978-1-4939-8663-7_14. PubMed
Sensing of cytosolic LPS through caspy2 pyrin domain mediates noncanonical inflammasome activation in zebrafish. Yang D, Zheng X, Chen S, Wang Z, Xu W, Tan J, Hu T, Hou M, Wang W, Gu Z, Wang Q, Zhang R, Zhang Y, Liu Q. Nat Commun. 2018 Aug 3;9(1):3052. doi: 10.1038/s41467-018-04984-1. PubMed
NOVA1 regulates hTERT splicing and cell growth in non-small cell lung cancer. Ludlow AT, Wong MS, Robin JD, Batten K, Yuan L, Lai TP, Dahlson N, Zhang L, Mender I, Tedone E, Sayed ME, Wright WE, Shay JW. Nat Commun. 2018 Aug 6;9(1):3112. doi: 10.1038/s41467-018-05582-x. PubMed
CHCHD2 accumulates in distressed mitochondria and facilitates oligomerization of CHCHD10. Huang X, Wu BP, Nguyen D, Liu YT, Marani M, Hench J, Benit P, Kozjak-Pavlovic V, Rustin P, Frank S, Narendra DP. Hum Mol Genet. 2018 Nov 15;27(22):3881-3900. doi: 10.1093/hmg/ddy270. PubMed
WDR62 mediates TNFalpha-dependent JNK activation via TRAF2-MLK3 axis. Prinz E, Aviram S, Aronheim A. Mol Biol Cell. 2018 Oct 1;29(20):2470-2480. doi: 10.1091/mbc.E17-08-0504. Epub 2018 Aug 9. PubMed
Genome-wide CRISPR screen identifies TMEM41B as a gene required for autophagosome formation. Morita K, Hama Y, Izume T, Tamura N, Ueno T, Yamashita Y, Sakamaki Y, Mimura K, Morishita H, Shihoya W, Nureki O, Mano H, Mizushima N. J Cell Biol. 2018 Aug 9. pii: jcb.201804132. doi: 10.1083/jcb.201804132. PubMed Associated Plasmids pMXs GFP-LC3-RFP pMRXIP TMEM41B-GFP pMRXIP TMEM41B-3xFLAG pMRXIP 3xFLAG-VMP1 pMXsIP GFP-VMP1
Identification of novel GLI1 target genes and regulatory circuits in human cancer cells. Diao Y, Rahman MF, Vyatkin Y, Azatyan A, St Laurent G, Kapranov P, Zaphiropoulos PG. Mol Oncol. 2018 Oct;12(10):1718-1734. doi: 10.1002/1878-0261.12366. Epub 2018 Aug 30. PubMed
Loss of SETDB1 decompacts the inactive X chromosome in part through reactivation of an enhancer in the IL1RAPL1 gene. Sun Z, Chadwick BP. Epigenetics Chromatin. 2018 Aug 13;11(1):45. doi: 10.1186/s13072-018-0218-9. PubMed
Tumor Cell Autonomous RON Receptor Expression Promotes Prostate Cancer Growth Under Conditions of Androgen Deprivation. Brown NE, Paluch AM, Nashu MA, Komurov K, Waltz SE. Neoplasia. 2018 Sep;20(9):917-929. doi: 10.1016/j.neo.2018.07.003. Epub 2018 Aug 15. PubMed
Mutant allele quantification reveals a genetic basis for TP53 mutation-driven castration resistance in prostate cancer cells. Lei K, Sun R, Chen LH, Diplas BH, Moure CJ, Wang W, Hansen LJ, Tao Y, Chen X, Chen CJ, Greer PK, Zhao F, Yan H, Bigner DD, Huang J, He Y. Sci Rep. 2018 Aug 21;8(1):12507. doi: 10.1038/s41598-018-30062-z. PubMed
Macropinosome formation by tent pole ruffling in macrophages. Condon ND, Heddleston JM, Chew TL, Luo L, McPherson PS, Ioannou MS, Hodgson L, Stow JL, Wall AA. J Cell Biol. 2018 Nov 5;217(11):3873-3885. doi: 10.1083/jcb.201804137. Epub 2018 Aug 27. PubMed
Double genetic disruption of lactate dehydrogenases A and B is required to ablate the "Warburg effect" restricting tumor growth to oxidative metabolism. Zdralevic M, Brand A, Di Ianni L, Dettmer K, Reinders J, Singer K, Peter K, Schnell A, Bruss C, Decking SM, Koehl G, Felipe-Abrio B, Durivault J, Bayer P, Evangelista M, O'Brien T, Oefner PJ, Renner K, Pouyssegur J, Kreutz M. J Biol Chem. 2018 Oct 12;293(41):15947-15961. doi: 10.1074/jbc.RA118.004180. Epub 2018 Aug 29. PubMed
CRL4(AMBRA1) targets Elongin C for ubiquitination and degradation to modulate CRL5 signaling. Chen SH, Jang GM, Huttenhain R, Gordon DE, Du D, Newton BW, Johnson JR, Hiatt J, Hultquist JF, Johnson TL, Liu YL, Burton LA, Ye J, Reichermeier KM, Stroud RM, Marson A, Debnath J, Gross JD, Krogan NJ. EMBO J. 2018 Sep 14;37(18). pii: embj.201797508. doi: 10.15252/embj.201797508. Epub 2018 Aug 30. PubMed
The Protein Coded by a Short Open Reading Frame, Not by the Annotated Coding Sequence, Is the Main Gene Product of the Dual-Coding Gene MIEF1. Delcourt V, Brunelle M, Roy AV, Jacques JF, Salzet M, Fournier I, Roucou X. Mol Cell Proteomics. 2018 Dec;17(12):2402-2411. doi: 10.1074/mcp.RA118.000593. Epub 2018 Sep 4. PubMed
Stage-specific epigenetic regulation of CD4 expression by coordinated enhancer elements during T cell development. Issuree PD, Day K, Au C, Raviram R, Zappile P, Skok JA, Xue HH, Myers RM, Littman DR. Nat Commun. 2018 Sep 5;9(1):3594. doi: 10.1038/s41467-018-05834-w. PubMed
Highly efficient genome editing by CRISPR-Cpf1 using CRISPR RNA with a uridinylate-rich 3'-overhang. Bin Moon S, Lee JM, Kang JG, Lee NE, Ha DI, Kim DY, Kim SH, Yoo K, Kim D, Ko JH, Kim YS. Nat Commun. 2018 Sep 7;9(1):3651. doi: 10.1038/s41467-018-06129-w. PubMed
beta-Hydroxybutyrate Prevents Vascular Senescence through hnRNP A1-Mediated Upregulation of Oct4. Han YM, Bedarida T, Ding Y, Somba BK, Lu Q, Wang Q, Song P, Zou MH. Mol Cell. 2018 Sep 20;71(6):1064-1078.e5. doi: 10.1016/j.molcel.2018.07.036. Epub 2018 Sep 6. PubMed
OXA1L mutations cause mitochondrial encephalopathy and a combined oxidative phosphorylation defect. Thompson K, Mai N, Olahova M, Scialo F, Formosa LE, Stroud DA, Garrett M, Lax NZ, Robertson FM, Jou C, Nascimento A, Ortez C, Jimenez-Mallebrera C, Hardy SA, He L, Brown GK, Marttinen P, McFarland R, Sanz A, Battersby BJ, Bonnen PE, Ryan MT, Chrzanowska-Lightowlers ZM, Lightowlers RN, Taylor RW. EMBO Mol Med. 2018 Nov;10(11). pii: emmm.201809060. doi: 10.15252/emmm.201809060. PubMed
Human Host Range Restriction of the Vaccinia Virus C7/K1 Double Deletion Mutant Is Mediated by an Atypical Mode of Translation Inhibition. Sivan G, Glushakow-Smith SG, Katsafanas GC, Americo JL, Moss B. J Virol. 2018 Nov 12;92(23). pii: JVI.01329-18. doi: 10.1128/JVI.01329-18. Print 2018 Dec 1. PubMed
Screening for Factors Involved in X Chromosome Inactivation Using Haploid ESCs. Monfort A, Di Minin G, Wutz A. Methods Mol Biol. 2018;1861:1-18. doi: 10.1007/978-1-4939-8766-5_1. PubMed
Anthropoid primate-specific retroviral element THE1B controls expression of CRH in placenta and alters gestation length. Dunn-Fletcher CE, Muglia LM, Pavlicev M, Wolf G, Sun MA, Hu YC, Huffman E, Tumukuntala S, Thiele K, Mukherjee A, Zoubovsky S, Zhang X, Swaggart KA, Lamm KYB, Jones H, Macfarlan TS, Muglia LJ. PLoS Biol. 2018 Sep 19;16(9):e2006337. doi: 10.1371/journal.pbio.2006337. eCollection 2018 Sep. PubMed
Nanoparticles Based on Poly (beta-Amino Ester) and HPV16-Targeting CRISPR/shRNA as Potential Drugs for HPV16-Related Cervical Malignancy. Zhu D, Shen H, Tan S, Hu Z, Wang L, Yu L, Tian X, Ding W, Ren C, Gao C, Cheng J, Deng M, Liu R, Hu J, Xi L, Wu P, Zhang Z, Ma D, Wang H. Mol Ther. 2018 Oct 3;26(10):2443-2455. doi: 10.1016/j.ymthe.2018.07.019. Epub 2018 Jul 25. PubMed
Complex formation of sphingomyelin synthase 1 with glucosylceramide synthase increases sphingomyelin and decreases glucosylceramide levels. Hayashi Y, Nemoto-Sasaki Y, Matsumoto N, Hama K, Tanikawa T, Oka S, Saeki T, Kumasaka T, Koizumi T, Arai S, Wada I, Yokoyama K, Sugiura T, Yamashita A. J Biol Chem. 2018 Nov 9;293(45):17505-17522. doi: 10.1074/jbc.RA118.002048. Epub 2018 Sep 21. PubMed
Genome Engineering of Hybridomas to Generate Stable Cell Lines for Antibody Expression. Parola C, Mason DM, Zingg A, Neumeier D, Reddy ST. Methods Mol Biol. 2018;1850:79-111. doi: 10.1007/978-1-4939-8730-6_7. PubMed
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Loperamide, pimozide, and STF-62247 trigger autophagy-dependent cell death in glioblastoma cells. Zielke S, Meyer N, Mari M, Abou-El-Ardat K, Reggiori F, van Wijk SJL, Kogel D, Fulda S. Cell Death Dis. 2018 Sep 24;9(10):994. doi: 10.1038/s41419-018-1003-1. PubMed
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Frequent structural variations involving programmed death ligands in Epstein-Barr virus-associated lymphomas. Kataoka K, Miyoshi H, Sakata S, Dobashi A, Couronne L, Kogure Y, Sato Y, Nishida K, Gion Y, Shiraishi Y, Tanaka H, Chiba K, Watatani Y, Kakiuchi N, Shiozawa Y, Yoshizato T, Yoshida K, Makishima H, Sanada M, Onozawa M, Teshima T, Yoshiki Y, Ishida T, Suzuki K, Shimada K, Tomita A, Kato M, Ota Y, Izutsu K, Demachi-Okamura A, Akatsuka Y, Miyano S, Yoshino T, Gaulard P, Hermine O, Takeuchi K, Ohshima K, Ogawa S. Leukemia. 2019 Jul;33(7):1687-1699. doi: 10.1038/s41375-019-0380-5. Epub 2019 Jan 25. PubMed
Overexpression of NEUROG2 and NEUROG1 in human embryonic stem cells produces a network of excitatory and inhibitory neurons. Lu C, Shi X, Allen A, Baez-Nieto D, Nikish A, Sanjana NE, Pan JQ. FASEB J. 2019 Apr;33(4):5287-5299. doi: 10.1096/fj.201801110RR. Epub 2019 Jan 30. PubMed
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Programmed cell death ligand 1 disruption by clustered regularly interspaced short palindromic repeats/Cas9-genome editing promotes antitumor immunity and suppresses ovarian cancer progression. Yahata T, Mizoguchi M, Kimura A, Orimo T, Toujima S, Kuninaka Y, Nosaka M, Ishida Y, Sasaki I, Fukuda-Ohta Y, Hemmi H, Iwahashi N, Noguchi T, Kaisho T, Kondo T, Ino K. Cancer Sci. 2019 Apr;110(4):1279-1292. doi: 10.1111/cas.13958. Epub 2019 Feb 27. PubMed
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Magnesium-sensitive upstream ORF controls PRL phosphatase expression to mediate energy metabolism. Hardy S, Kostantin E, Wang SJ, Hristova T, Galicia-Vazquez G, Baranov PV, Pelletier J, Tremblay ML. Proc Natl Acad Sci U S A. 2019 Feb 19;116(8):2925-2934. doi: 10.1073/pnas.1815361116. Epub 2019 Feb 4. PubMed
Caveolin-1alpha regulates primary cilium length by controlling RhoA GTPase activity. Rangel L, Bernabe-Rubio M, Fernandez-Barrera J, Casares-Arias J, Millan J, Alonso MA, Correas I. Sci Rep. 2019 Feb 4;9(1):1116. doi: 10.1038/s41598-018-38020-5. PubMed
A Genome-wide Haploid Genetic Screen Identifies Regulators of Glutathione Abundance and Ferroptosis Sensitivity. Cao JY, Poddar A, Magtanong L, Lumb JH, Mileur TR, Reid MA, Dovey CM, Wang J, Locasale JW, Stone E, Cole SPC, Carette JE, Dixon SJ. Cell Rep. 2019 Feb 5;26(6):1544-1556.e8. doi: 10.1016/j.celrep.2019.01.043. PubMed
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Analysis of Transcriptional Regulation in Bone Cells. Jin H, Sophocleous A, Azfer A, Ralston SH. Methods Mol Biol. 2019;1914:145-167. doi: 10.1007/978-1-4939-8997-3_8. PubMed
Nuclear RNA foci from C9ORF72 expansion mutation form paraspeckle-like bodies. Bajc Cesnik A, Darovic S, Prpar Mihevc S, Stalekar M, Malnar M, Motaln H, Lee YB, Mazej J, Pohleven J, Grosch M, Modic M, Fonovic M, Turk B, Drukker M, Shaw CE, Rogelj B. J Cell Sci. 2019 Mar 7;132(5). pii: jcs.224303. doi: 10.1242/jcs.224303. PubMed
Optimization of CRISPR/Cas9 Technology to Knock Out Genes of Interest in Aneuploid Cell Lines. Dyikanov DT, Vasiluev PA, Rysenkova KD, Aleksandrushkina NA, Tyurin-Kuzmin PA, Kulebyakin KY, Rubtsov YP, Shmakova AA, Evseeva MN, Balatskiy AV, Semina EV, Rostovtseva AI, Makarevich PI, Karagyaur MN. Tissue Eng Part C Methods. 2019 Mar;25(3):168-175. doi: 10.1089/ten.TEC.2018.0365. PubMed
SLFN11 can sensitize tumor cells towards IFN-gamma-mediated T cell killing. Mezzadra R, de Bruijn M, Jae LT, Gomez-Eerland R, Duursma A, Scheeren FA, Brummelkamp TR, Schumacher TN. PLoS One. 2019 Feb 12;14(2):e0212053. doi: 10.1371/journal.pone.0212053. eCollection 2019. PubMed
MARCH8 Ubiquitinates the Hepatitis C Virus Nonstructural 2 Protein and Mediates Viral Envelopment. Kumar S, Barouch-Bentov R, Xiao F, Schor S, Pu S, Biquand E, Lu A, Lindenbach BD, Jacob Y, Demeret C, Einav S. Cell Rep. 2019 Feb 12;26(7):1800-1814.e5. doi: 10.1016/j.celrep.2019.01.075. PubMed
Statins and Histone Deacetylase Inhibitors Affect Lamin A/C - Histone Deacetylase 2 Interaction in Human Cells. Mattioli E, Andrenacci D, Mai A, Valente S, Robijns J, De Vos WH, Capanni C, Lattanzi G. Front Cell Dev Biol. 2019 Jan 31;7:6. doi: 10.3389/fcell.2019.00006. eCollection 2019. PubMed
Precise tuning of gene expression levels in mammalian cells. Michaels YS, Barnkob MB, Barbosa H, Baeumler TA, Thompson MK, Andre V, Colin-York H, Fritzsche M, Gileadi U, Sheppard HM, Knapp DJHF, Milne TA, Cerundolo V, Fulga TA. Nat Commun. 2019 Feb 18;10(1):818. doi: 10.1038/s41467-019-08777-y. PubMed Associated Plasmids OVA-miSFIT-2xPerfect OVA-miSFIT-1xPerfect OVA-miSFIT-8-G OVA-miSFIT-19-G OVA-miSFIT-17-T More ...
Allosteric enhancement of ORP1-mediated cholesterol transport by PI(4,5)P2/PI(3,4)P2. Dong J, Du X, Wang H, Wang J, Lu C, Chen X, Zhu Z, Luo Z, Yu L, Brown AJ, Yang H, Wu JW. Nat Commun. 2019 Feb 19;10(1):829. doi: 10.1038/s41467-019-08791-0. PubMed
Targeted editing of the PSIP1 gene encoding LEDGF/p75 protects cells against HIV infection. Lampi Y, Van Looveren D, Vranckx LS, Thiry I, Bornschein S, Debyser Z, Gijsbers R. Sci Rep. 2019 Feb 20;9(1):2389. doi: 10.1038/s41598-019-38718-0. PubMed
A single-cell molecular map of mouse gastrulation and early organogenesis. Pijuan-Sala B, Griffiths JA, Guibentif C, Hiscock TW, Jawaid W, Calero-Nieto FJ, Mulas C, Ibarra-Soria X, Tyser RCV, Ho DLL, Reik W, Srinivas S, Simons BD, Nichols J, Marioni JC, Gottgens B. Nature. 2019 Feb;566(7745):490-495. doi: 10.1038/s41586-019-0933-9. Epub 2019 Feb 20. PubMed
Gene Editing of Mouse Embryonic and Epiblast Stem Cells. Sibbritt T, Osteil P, Fan X, Sun J, Salehin N, Knowles H, Shen J, Tam PPL. Methods Mol Biol. 2019;1940:77-95. doi: 10.1007/978-1-4939-9086-3_6. PubMed
Neuron-Specific Genome Modification in the Adult Rat Brain Using CRISPR-Cas9 Transgenic Rats. Back S, Necarsulmer J, Whitaker LR, Coke LM, Koivula P, Heathward EJ, Fortuno LV, Zhang Y, Yeh CG, Baldwin HA, Spencer MD, Mejias-Aponte CA, Pickel J, Hoffman AF, Spivak CE, Lupica CR, Underhill SM, Amara SG, Domanskyi A, Anttila JE, Airavaara M, Hope BT, Hamra FK, Richie CT, Harvey BK. Neuron. 2019 Feb 8. pii: S0896-6273(19)30062-5. doi: 10.1016/j.neuron.2019.01.035. PubMed Associated Plasmids pOTTC1032 - pAAV EF1a Nuc-flox(mCherry)-EGFP pOTTC1442 - pAAV CMV-IE Nuc-iRFP-2A-iCre pOTTC1440 - pAAV CMV-IE Nuc-iRFP-2A-Flpo pOTTC1124 - pAAV MeCP2 SpCas9(D10A) pOTTC1088 - pAAV TH gRNA A+B pair EF1a EGFP More ...
The Crohn's disease associated SNP rs6651252 impacts MYC gene expression in human colonic epithelial cells. Matthews SM, Eshelman MA, Berg AS, Koltun WA, Yochum GS. PLoS One. 2019 Feb 22;14(2):e0212850. doi: 10.1371/journal.pone.0212850. eCollection 2019. PubMed
Pan-Cancer Analyses Reveal Genomic Features of FOXM1 Overexpression in Cancer. Barger CJ, Branick C, Chee L, Karpf AR. Cancers (Basel). 2019 Feb 21;11(2). pii: cancers11020251. doi: 10.3390/cancers11020251. PubMed Associated Plasmids pCW57-MCS1-2A-MCS2 pCW57-GFP-2A-MCS pCW57-RFP-P2A-MCS pCW57-MCS1-P2A-MCS2 (Blast) pCW57-MCS1-P2A-MCS2 (Hygro) More ...
Precisely controlling endogenous protein dosage in hPSCs and derivatives to model FOXG1 syndrome. Zhu W, Zhang B, Li M, Mo F, Mi T, Wu Y, Teng Z, Zhou Q, Li W, Hu B. Nat Commun. 2019 Feb 25;10(1):928. doi: 10.1038/s41467-019-08841-7. PubMed
Inhibition of Tropomyosin Receptor Kinase A Signaling Negatively Regulates Megakaryopoiesis and induces Thrombopoiesis. Kizilyer A, Singh MV, Singh VB, Suwunnakorn S, Palis J, Maggirwar SB. Sci Rep. 2019 Feb 26;9(1):2781. doi: 10.1038/s41598-019-39385-x. PubMed
VEGFC acts as a double-edged sword in renal cell carcinoma aggressiveness. Ndiaye PD, Dufies M, Giuliano S, Douguet L, Grepin R, Durivault J, Lenormand P, Glisse N, Mintcheva J, Vouret-Craviari V, Mograbi B, Wurmser M, Ambrosetti D, Rioux-Leclercq N, Maire P, Pages G. Theranostics. 2019 Jan 21;9(3):661-675. doi: 10.7150/thno.27794. eCollection 2019. PubMed
Targeting the functional interplay between endoplasmic reticulum oxidoreductin-1alpha and protein disulfide isomerase suppresses the progression of cervical cancer. Zhang Y, Li T, Zhang L, Shangguan F, Shi G, Wu X, Cui Y, Wang X, Wang X, Liu Y, Lu B, Wei T, Wang CC, Wang L. EBioMedicine. 2019 Mar;41:408-419. doi: 10.1016/j.ebiom.2019.02.041. Epub 2019 Feb 27. PubMed
Chromosome segregation errors generate a diverse spectrum of simple and complex genomic rearrangements. Ly P, Brunner SF, Shoshani O, Kim DH, Lan W, Pyntikova T, Flanagan AM, Behjati S, Page DC, Campbell PJ, Cleveland DW. Nat Genet. 2019 Apr;51(4):705-715. doi: 10.1038/s41588-019-0360-8. Epub 2019 Mar 4. PubMed
Uracil-DNA glycosylase UNG1 isoform variant supports class switch recombination and repairs nuclear genomic uracil. Sarno A, Lundbaek M, Liabakk NB, Aas PA, Mjelle R, Hagen L, Sousa MML, Krokan HE, Kavli B. Nucleic Acids Res. 2019 May 21;47(9):4569-4585. doi: 10.1093/nar/gkz145. PubMed
Neuronal apolipoprotein E4 increases cell death and phosphorylated tau release in alzheimer disease. Wadhwani AR, Affaneh A, Van Gulden S, Kessler JA. Ann Neurol. 2019 May;85(5):726-739. doi: 10.1002/ana.25455. Epub 2019 Mar 27. PubMed
TAK1 suppresses RIPK1-dependent cell death and is associated with disease progression in melanoma. Podder B, Gutta C, Rozanc J, Gerlach E, Feoktistova M, Panayotova-Dimitrova D, Alexopoulos LG, Leverkus M, Rehm M. Cell Death Differ. 2019 Mar 8. pii: 10.1038/s41418-019-0315-8. doi: 10.1038/s41418-019-0315-8. PubMed
FIP200 Claw Domain Binding to p62 Promotes Autophagosome Formation at Ubiquitin Condensates. Turco E, Witt M, Abert C, Bock-Bierbaum T, Su MY, Trapannone R, Sztacho M, Danieli A, Shi X, Zaffagnini G, Gamper A, Schuschnig M, Fracchiolla D, Bernklau D, Romanov J, Hartl M, Hurley JH, Daumke O, Martens S. Mol Cell. 2019 Apr 18;74(2):330-346.e11. doi: 10.1016/j.molcel.2019.01.035. Epub 2019 Mar 7. PubMed
CRISPR-Cas9 corrects Duchenne muscular dystrophy exon 44 deletion mutations in mice and human cells. Min YL, Li H, Rodriguez-Caycedo C, Mireault AA, Huang J, Shelton JM, McAnally JR, Amoasii L, Mammen PPA, Bassel-Duby R, Olson EN. Sci Adv. 2019 Mar 6;5(3):eaav4324. doi: 10.1126/sciadv.aav4324. eCollection 2019 Mar. PubMed
H3K27M induces defective chromatin spread of PRC2-mediated repressive H3K27me2/me3 and is essential for glioma tumorigenesis. Harutyunyan AS, Krug B, Chen H, Papillon-Cavanagh S, Zeinieh M, De Jay N, Deshmukh S, Chen CCL, Belle J, Mikael LG, Marchione DM, Li R, Nikbakht H, Hu B, Cagnone G, Cheung WA, Mohammadnia A, Bechet D, Faury D, McConechy MK, Pathania M, Jain SU, Ellezam B, Weil AG, Montpetit A, Salomoni P, Pastinen T, Lu C, Lewis PW, Garcia BA, Kleinman CL, Jabado N, Majewski J. Nat Commun. 2019 Mar 19;10(1):1262. doi: 10.1038/s41467-019-09140-x. PubMed
[A Plasmid-Expressed CRISPR/Cas9 System Suppresses Replication of HSV Type I in a Vero Cell Culture]. Karpov DS, Karpov VL, Klimova RR, Demidova NA, Kushch AA. Mol Biol (Mosk). 2019 Jan-Feb;53(1):91-100. doi: 10.1134/S0026898419010051. PubMed
Induced Neurons for the Study of Neurodegenerative and Neurodevelopmental Disorders. Sauter EJ, Kutsche LK, Klapper SD, Busskamp V. Methods Mol Biol. 2019;1942:101-121. doi: 10.1007/978-1-4939-9080-1_9. PubMed Associated Plasmids PB-TRE-EGFP-EF1a-rtTA
Targeting intrinsic RIG-I signaling turns melanoma cells into type I interferon-releasing cellular antitumor vaccines. Bek S, Stritzke F, Wintges A, Nedelko T, Bohmer DFR, Fischer JC, Haas T, Poeck H, Heidegger S. Oncoimmunology. 2019 Feb 11;8(4):e1570779. doi: 10.1080/2162402X.2019.1570779. eCollection 2019. PubMed
Targeting FER Kinase Inhibits Melanoma Growth and Metastasis. Ivanova IA, Arulanantham S, Barr K, Cepeda M, Parkins KM, Hamilton AM, Johnston D, Penuela S, Hess DA, Ronald JA, Dagnino L. Cancers (Basel). 2019 Mar 24;11(3). pii: cancers11030419. doi: 10.3390/cancers11030419. PubMed
Collagen facilitates the colorectal cancer stemness and metastasis through an integrin/PI3K/AKT/Snail signaling pathway. Wu X, Cai J, Zuo Z, Li J. Biomed Pharmacother. 2019 Jun;114:108708. doi: 10.1016/j.biopha.2019.108708. Epub 2019 Mar 24. PubMed
Defined conditions for propagation and manipulation of mouse embryonic stem cells. Mulas C, Kalkan T, von Meyenn F, Leitch HG, Nichols J, Smith A. Development. 2019 Mar 26;146(6). pii: 146/6/dev173146. doi: 10.1242/dev.173146. PubMed
ATG9A shapes the forming autophagosome through Arfaptin 2 and phosphatidylinositol 4-kinase IIIbeta. Judith D, Jefferies HBJ, Boeing S, Frith D, Snijders AP, Tooze SA. J Cell Biol. 2019 May 6;218(5):1634-1652. doi: 10.1083/jcb.201901115. Epub 2019 Mar 27. PubMed
Complement C4 Prevents Viral Infection through Capsid Inactivation. Bottermann M, Foss S, Caddy SL, Clift D, van Tienen LM, Vaysburd M, Cruickshank J, O'Connell K, Clark J, Mayes K, Higginson K, Lode HE, McAdam MB, Sandlie I, Andersen JT, James LC. Cell Host Microbe. 2019 Apr 10;25(4):617-629.e7. doi: 10.1016/j.chom.2019.02.016. Epub 2019 Mar 26. PubMed
Human UTP14a promotes angiogenesis through upregulating PDGFA expression in colorectal cancer. Ren P, Sun X, Zhang C, Wang L, Xing B, Du X. Biochem Biophys Res Commun. 2019 May 14;512(4):871-876. doi: 10.1016/j.bbrc.2019.03.142. Epub 2019 Mar 28. PubMed
Disruption of Telomerase RNA Maturation Kinetics Precipitates Disease. Roake CM, Chen L, Chakravarthy AL, Ferrell JE Jr, Raffa GD, Artandi SE. Mol Cell. 2019 May 16;74(4):688-700.e3. doi: 10.1016/j.molcel.2019.02.033. Epub 2019 Mar 28. PubMed
Discovery of Covalent CDK14 Inhibitors with Pan-TAIRE Family Specificity. Ferguson FM, Doctor ZM, Ficarro SB, Browne CM, Marto JA, Johnson JL, Yaron TM, Cantley LC, Kim ND, Sim T, Berberich MJ, Kalocsay M, Sorger PK, Gray NS. Cell Chem Biol. 2019 Jun 20;26(6):804-817.e12. doi: 10.1016/j.chembiol.2019.02.015. Epub 2019 Mar 28. PubMed
Genetic compensation triggered by mutant mRNA degradation. El-Brolosy MA, Kontarakis Z, Rossi A, Kuenne C, Gunther S, Fukuda N, Kikhi K, Boezio GLM, Takacs CM, Lai SL, Fukuda R, Gerri C, Giraldez AJ, Stainier DYR. Nature. 2019 Apr;568(7751):193-197. doi: 10.1038/s41586-019-1064-z. Epub 2019 Apr 3. PubMed
Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation. Lee SH, Mayr C. Mol Cell. 2019 May 16;74(4):701-712.e9. doi: 10.1016/j.molcel.2019.03.006. Epub 2019 Apr 1. PubMed Associated Plasmids pcDNA-GFP pcDNA-GFP-BIRC3-NU pcDNA-GFP-BIRC3-SU pcDNA-GFP-BIRC3-LU
HLA Class I-sensitized Renal Transplant Patients Have Antibody Binding to SLA Class I Epitopes. Martens GR, Ladowski JM, Estrada J, Wang ZY, Reyes LM, Easlick J, Smith C, Butler JR, Sidner RA, Eckhoff DE, Tector M, Tector J. Transplantation. 2019 Aug;103(8):1620-1629. doi: 10.1097/TP.0000000000002739. PubMed
CRISPR/Cas9 genome editing of SLC37A4 gene elucidates the role of molecular markers of endoplasmic reticulum stress and apoptosis in renal involvement in glycogen storage disease type Ib. Skakic A, Andjelkovic M, Tosic N, Klaassen K, Djordjevic M, Pavlovic S, Stojiljkovic M. Gene. 2019 Jun 30;703:17-25. doi: 10.1016/j.gene.2019.04.002. Epub 2019 Apr 3. PubMed
CRISPR/Cas9 engineering of ERK5 identifies its FAK/PYK2 dependent role in adhesion-mediated cell survival. Ali M, Mutahir Z, Riaz A. Biochem Biophys Res Commun. 2019 May 21;513(1):179-185. doi: 10.1016/j.bbrc.2019.03.145. Epub 2019 Apr 2. PubMed
Generation of GLA-Knockout Human Embryonic Stem Cell Lines to Model Autophagic Dysfunction and Exosome Secretion in Fabry Disease-Associated Hypertrophic Cardiomyopathy. Song HY, Chien CS, Yarmishyn AA, Chou SJ, Yang YP, Wang ML, Wang CY, Leu HB, Yu WC, Chang YL, Chiou SH. Cells. 2019 Apr 8;8(4). pii: cells8040327. doi: 10.3390/cells8040327. PubMed
Cathelicidin is a "fire alarm", generating protective NLRP3-dependent airway epithelial cell inflammatory responses during infection with Pseudomonas aeruginosa. McHugh BJ, Wang R, Li HN, Beaumont PE, Kells R, Stevens H, Young L, Rossi AG, Gray RD, Dorin JR, Gwyer Findlay EL, Brough D, Davidson DJ. PLoS Pathog. 2019 Apr 12;15(4):e1007694. doi: 10.1371/journal.ppat.1007694. eCollection 2019 Apr. PubMed
Glutamate-Releasing SWELL1 Channel in Astrocytes Modulates Synaptic Transmission and Promotes Brain Damage in Stroke. Yang J, Vitery MDC, Chen J, Osei-Owusu J, Chu J, Qiu Z. Neuron. 2019 May 22;102(4):813-827.e6. doi: 10.1016/j.neuron.2019.03.029. Epub 2019 Apr 11. PubMed
NIPSNAP1 and NIPSNAP2 Act as "Eat Me" Signals for Mitophagy. Princely Abudu Y, Pankiv S, Mathai BJ, Hakon Lystad A, Bindesboll C, Brenne HB, Yoke Wui Ng M, Thiede B, Yamamoto A, Mutugi Nthiga T, Lamark T, Esguerra CV, Johansen T, Simonsen A. Dev Cell. 2019 May 20;49(4):509-525.e12. doi: 10.1016/j.devcel.2019.03.013. Epub 2019 Apr 11. PubMed
Cell-specific CRISPR-Cas9 activation by microRNA-dependent expression of anti-CRISPR proteins. Hoffmann MD, Aschenbrenner S, Grosse S, Rapti K, Domenger C, Fakhiri J, Mastel M, Borner K, Eils R, Grimm D, Niopek D. Nucleic Acids Res. 2019 Apr 15. pii: 5458120. doi: 10.1093/nar/gkz271. PubMed Associated Plasmids AAV N-SpyCas9-Intein, U6-gRNA scaffold (F+E) AAV Intein-C-SpyCas9, CMV-AcrIIA4-scaffold (2xBsmBI sites) AAV Intein-C-SpyCas9, CMV-AcrIIA4-2xmiR-122 target sites pAAV-RSV-GFP-U6-Rosa26 gRNA (SpyCas9 scaffold) AAV CMV-driven AcrIIA4-scaffold (2xBsmBI sites) More ...
In utero gene editing for monogenic lung disease. Alapati D, Zacharias WJ, Hartman HA, Rossidis AC, Stratigis JD, Ahn NJ, Coons B, Zhou S, Li H, Singh K, Katzen J, Tomer Y, Chadwick AC, Musunuru K, Beers MF, Morrisey EE, Peranteau WH. Sci Transl Med. 2019 Apr 17;11(488). pii: 11/488/eaav8375. doi: 10.1126/scitranslmed.aav8375. PubMed
CRISPR-Cas9-Mediated Correction of the G189R-PAX2 Mutation in Induced Pluripotent Stem Cells from a Patient with Focal Segmental Glomerulosclerosis. Trionfini P, Ciampi O, Todeschini M, Ascanelli C, Longaretti L, Perico L, Remuzzi G, Benigni A, Tomasoni S. CRISPR J. 2019 Apr;2:108-120. doi: 10.1089/crispr.2018.0048. PubMed
Dishevelled-3 conformation dynamics analyzed by FRET-based biosensors reveals a key role of casein kinase 1. Harnos J, Canizal MCA, Jurasek M, Kumar J, Holler C, Schambony A, Hanakova K, Bernatik O, Zdrahal Z, Gomoryova K, Gybel T, Radaszkiewicz TW, Kravec M, Trantirek L, Rynes J, Dave Z, Fernandez-Llamazares AI, Vacha R, Tripsianes K, Hoffmann C, Bryja V. Nat Commun. 2019 Apr 18;10(1):1804. doi: 10.1038/s41467-019-09651-7. PubMed
ZFP30 promotes adipogenesis through the KAP1-mediated activation of a retrotransposon-derived Pparg2 enhancer. Chen W, Schwalie PC, Pankevich EV, Gubelmann C, Raghav SK, Dainese R, Cassano M, Imbeault M, Jang SM, Russeil J, Delessa T, Duc J, Trono D, Wolfrum C, Deplancke B. Nat Commun. 2019 Apr 18;10(1):1809. doi: 10.1038/s41467-019-09803-9. PubMed
Intrinsically Disordered Protein TEX264 Mediates ER-phagy. Chino H, Hatta T, Natsume T, Mizushima N. Mol Cell. 2019 Apr 11. pii: S1097-2765(19)30257-6. doi: 10.1016/j.molcel.2019.03.033. PubMed Associated Plasmids pCW57-CMV-ssRFP-GFP-KDEL pMRX-INU-TEX264-FLAG pMRX-INU-TEX264 LIR4A-FLAG pMRX-INU-FLAG-FAM134B pMRX-INU-FLAG-FAM134Bs More ...
Functional evaluation of transposable elements as enhancers in mouse embryonic and trophoblast stem cells. Todd CD, Deniz O, Taylor D, Branco MR. Elife. 2019 Apr 23;8. pii: 44344. doi: 10.7554/eLife.44344. PubMed
Cyclin-Dependent Kinase 5 (CDK5)-Mediated Phosphorylation of Upstream Stimulatory Factor 2 (USF2) Contributes to Carcinogenesis. Chi TF, Horbach T, Gotz C, Kietzmann T, Dimova EY. Cancers (Basel). 2019 Apr 12;11(4). pii: cancers11040523. doi: 10.3390/cancers11040523. PubMed
Direct Activation of Human MLKL by a Select Repertoire of Inositol Phosphate Metabolites. McNamara DE, Dovey CM, Hale AT, Quarato G, Grace CR, Guibao CD, Diep J, Nourse A, Cai CR, Wu H, Kalathur RC, Green DR, York JD, Carette JE, Moldoveanu T. Cell Chem Biol. 2019 Jun 20;26(6):863-877.e7. doi: 10.1016/j.chembiol.2019.03.010. Epub 2019 Apr 25. PubMed
Genome Editing in Mammalian Cell Lines using CRISPR-Cas. Liu KI, Sutrisnoh NB, Wang Y, Tan MH. J Vis Exp. 2019 Apr 11;(146). doi: 10.3791/59086. PubMed
Zfp217 mediates m6A mRNA methylation to orchestrate transcriptional and post-transcriptional regulation to promote adipogenic differentiation. Song T, Yang Y, Wei H, Xie X, Lu J, Zeng Q, Peng J, Zhou Y, Jiang S, Peng J. Nucleic Acids Res. 2019 Jul 9;47(12):6130-6144. doi: 10.1093/nar/gkz312. PubMed
Targeted deletion of BCL11A gene by CRISPR-Cas9 system for fetal hemoglobin reactivation: A promising approach for gene therapy of beta thalassemia disease. Khosravi MA, Abbasalipour M, Concordet JP, Berg JV, Zeinali S, Arashkia A, Azadmanesh K, Buch T, Karimipoor M. Eur J Pharmacol. 2019 Jul 5;854:398-405. doi: 10.1016/j.ejphar.2019.04.042. Epub 2019 Apr 27. PubMed
Highly efficient correction of structural mutations of 450 kb KIT locus in kidney cells of Yorkshire pig by CRISPR/Cas9. Qin K, Liang X, Sun G, Shi X, Wang M, Liu H, Chen Y, Liu X, He Z. BMC Mol Cell Biol. 2019 Apr 3;20(1):4. doi: 10.1186/s12860-019-0184-5. PubMed
Ribozyme-mediated, multiplex CRISPR gene editing and CRISPR interference (CRISPRi) in rodent-infectious Plasmodium yoelii. Walker MP, Lindner SE. J Biol Chem. 2019 Jun 14;294(24):9555-9566. doi: 10.1074/jbc.RA118.007121. Epub 2019 May 1. PubMed Associated Plasmids pSL1166 pSL1211 pSL1394 pSL1433 pSL1045 More ...
Cross-Regulation between TDP-43 and Paraspeckles Promotes Pluripotency-Differentiation Transition. Modic M, Grosch M, Rot G, Schirge S, Lepko T, Yamazaki T, Lee FCY, Rusha E, Shaposhnikov D, Palo M, Merl-Pham J, Cacchiarelli D, Rogelj B, Hauck SM, von Mering C, Meissner A, Lickert H, Hirose T, Ule J, Drukker M. Mol Cell. 2019 Jun 6;74(5):951-965.e13. doi: 10.1016/j.molcel.2019.03.041. Epub 2019 Apr 29. PubMed
Chemoproteomic Profiling Uncovers CDK4-Mediated Phosphorylation of the Translational Suppressor 4E-BP1. Mitchell DC, Menon A, Garner AL. Cell Chem Biol. 2019 Jul 18;26(7):980-990.e8. doi: 10.1016/j.chembiol.2019.03.012. Epub 2019 May 2. PubMed
An acquired scaffolding function of the DNAJ-PKAc fusion contributes to oncogenic signaling in fibrolamellar carcinoma. Turnham RE, Smith FD, Kenerson HL, Omar MH, Golkowski M, Garcia I, Bauer R, Lau HT, Sullivan KM, Langeberg LK, Ong SE, Riehle KJ, Yeung RS, Scott JD. Elife. 2019 May 7;8. pii: 44187. doi: 10.7554/eLife.44187. PubMed
Enhanced Dendritic Actin Network Formation in Extended Lamellipodia Drives Proliferation in Growth-Challenged Rac1(P29S) Melanoma Cells. Mohan AS, Dean KM, Isogai T, Kasitinon SY, Murali VS, Roudot P, Groisman A, Reed DK, Welf ES, Han SJ, Noh J, Danuser G. Dev Cell. 2019 May 6;49(3):444-460.e9. doi: 10.1016/j.devcel.2019.04.007. PubMed
Dlg1 activates beta-catenin signaling to regulate retinal angiogenesis and the blood-retina and blood-brain barriers. Cho C, Wang Y, Smallwood PM, Williams J, Nathans J. Elife. 2019 May 8;8. pii: 45542. doi: 10.7554/eLife.45542. PubMed
Effects of histone deacetylase inhibitor Scriptaid and parathyroid hormone on osteocyte functions and metabolism. Sun N, Uda Y, Azab E, Kochen A, Santos RNCE, Shi C, Kobayashi T, Wein MN, Divieti Pajevic P. J Biol Chem. 2019 Jun 21;294(25):9722-9733. doi: 10.1074/jbc.RA118.007312. Epub 2019 May 8. PubMed
Identification of on-target mutagenesis during correction of a beta-thalassemia splice mutation in iPS cells with optimised CRISPR/Cas9-double nickase reveals potential safety concerns. Alateeq S, Ovchinnikov D, Tracey T, Whitworth D, Al-Rubaish A, Al-Ali A, Wolvetang E. APL Bioeng. 2018 Dec 3;2(4):046103. doi: 10.1063/1.5048625. eCollection 2018 Dec. PubMed
Genome Editing in Zebrafish Using CRISPR-Cas9: Applications for Developmental Toxicology. Warner BK, Alder JK, Suli A. Methods Mol Biol. 2019;1965:235-250. doi: 10.1007/978-1-4939-9182-2_16. PubMed
Splice donor site sgRNAs enhance CRISPR/Cas9-mediated knockout efficiency. Garcia-Tunon I, Alonso-Perez V, Vuelta E, Perez-Ramos S, Herrero M, Mendez L, Hernandez-Sanchez JM, Martin-Izquierdo M, Saldana R, Sevilla J, Sanchez-Guijo F, Hernandez-Rivas JM, Sanchez-Martin M. PLoS One. 2019 May 9;14(5):e0216674. doi: 10.1371/journal.pone.0216674. eCollection 2019. PubMed
Pervasive H3K27 Acetylation Leads to ERV Expression and a Therapeutic Vulnerability in H3K27M Gliomas. Krug B, De Jay N, Harutyunyan AS, Deshmukh S, Marchione DM, Guilhamon P, Bertrand KC, Mikael LG, McConechy MK, Chen CCL, Khazaei S, Koncar RF, Agnihotri S, Faury D, Ellezam B, Weil AG, Ursini-Siegel J, De Carvalho DD, Dirks PB, Lewis PW, Salomoni P, Lupien M, Arrowsmith C, Lasko PF, Garcia BA, Kleinman CL, Jabado N, Mack SC. Cancer Cell. 2019 May 13;35(5):782-797.e8. doi: 10.1016/j.ccell.2019.04.004. PubMed
USP1 links platinum resistance to cancer cell dissemination by regulating Snail stability. Sonego M, Pellarin I, Costa A, Vinciguerra GLR, Coan M, Kraut A, D'Andrea S, Dall'Acqua A, Castillo-Tong DC, Califano D, Losito S, Spizzo R, Coute Y, Vecchione A, Belletti B, Schiappacassi M, Baldassarre G. Sci Adv. 2019 May 8;5(5):eaav3235. doi: 10.1126/sciadv.aav3235. eCollection 2019 May. PubMed
Molecular heterogeneity in peripheral T-cell lymphoma, not otherwise specified revealed by comprehensive genetic profiling. Watatani Y, Sato Y, Miyoshi H, Sakamoto K, Nishida K, Gion Y, Nagata Y, Shiraishi Y, Chiba K, Tanaka H, Zhao L, Ochi Y, Takeuchi Y, Takeda J, Ueno H, Kogure Y, Shiozawa Y, Kakiuchi N, Yoshizato T, Nakagawa MM, Nanya Y, Yoshida K, Makishima H, Sanada M, Sakata-Yanagimoto M, Chiba S, Matsuoka R, Noguchi M, Hiramoto N, Ishikawa T, Kitagawa J, Nakamura N, Tsurumi H, Miyazaki T, Kito Y, Miyano S, Shimoda K, Takeuchi K, Ohshima K, Yoshino T, Ogawa S, Kataoka K. Leukemia. 2019 May 15. pii: 10.1038/s41375-019-0473-1. doi: 10.1038/s41375-019-0473-1. PubMed
Targeted genomic integration of EGFP under tubulin beta 3 class III promoter and mEos2 under tryptophan hydroxylase 2 promoter does not produce sufficient levels of reporter gene expression. Menzorov AG, Orishchenko KE, Fishman VS, Shevtsova AA, Mungalov RV, Pristyazhnyuk IE, Kizilova EA, Matveeva NM, Alenina N, Bader M, Rubtsov NB, Serov OL. J Cell Biochem. 2019 May 20. doi: 10.1002/jcb.28981. PubMed
Opposite microglial activation stages upon loss of PGRN or TREM2 result in reduced cerebral glucose metabolism. Gotzl JK, Brendel M, Werner G, Parhizkar S, Sebastian Monasor L, Kleinberger G, Colombo AV, Deussing M, Wagner M, Winkelmann J, Diehl-Schmid J, Levin J, Fellerer K, Reifschneider A, Bultmann S, Bartenstein P, Rominger A, Tahirovic S, Smith ST, Madore C, Butovsky O, Capell A, Haass C. EMBO Mol Med. 2019 Jun;11(6). pii: emmm.201809711. doi: 10.15252/emmm.201809711. PubMed
Probing the Tumor Suppressor Function of BAP1 in CRISPR-Engineered Human Liver Organoids. Artegiani B, van Voorthuijsen L, Lindeboom RGH, Seinstra D, Heo I, Tapia P, Lopez-Iglesias C, Postrach D, Dayton T, Oka R, Hu H, van Boxtel R, van Es JH, Offerhaus J, Peters PJ, van Rheenen J, Vermeulen M, Clevers H. Cell Stem Cell. 2019 Jun 6;24(6):927-943.e6. doi: 10.1016/j.stem.2019.04.017. Epub 2019 May 23. PubMed
ARID1A spatially partitions interphase chromosomes. Wu S, Fatkhutdinov N, Rosin L, Luppino JM, Iwasaki O, Tanizawa H, Tang HY, Kossenkov AV, Gardini A, Noma KI, Speicher DW, Joyce EF, Zhang R. Sci Adv. 2019 May 22;5(5):eaaw5294. doi: 10.1126/sciadv.aaw5294. eCollection 2019 May. PubMed
Dynamic UTR Usage Regulates Alternative Translation to Modulate Gap Junction Formation during Stress and Aging. Zeitz MJ, Calhoun PJ, James CC, Taetzsch T, George KK, Robel S, Valdez G, Smyth JW. Cell Rep. 2019 May 28;27(9):2737-2747.e5. doi: 10.1016/j.celrep.2019.04.114. PubMed
The RIG-I pathway is involved in peripheral T cell lymphopenia in patients with dermatomyositis. Zhang L, Xia Q, Li W, Peng Q, Yang H, Lu X, Wang G. Arthritis Res Ther. 2019 May 29;21(1):131. doi: 10.1186/s13075-019-1905-z. PubMed
The intraflagellar transport protein IFT20 controls lysosome biogenesis by regulating the post-Golgi transport of acid hydrolases. Finetti F, Cassioli C, Cianfanelli V, Onnis A, Paccagnini E, Kabanova A, Baldari CT. Cell Death Differ. 2019 May 29. pii: 10.1038/s41418-019-0357-y. doi: 10.1038/s41418-019-0357-y. PubMed
Targeting histone deacetylase 3 (HDAC3) in the bone marrow microenvironment inhibits multiple myeloma proliferation by modulating exosomes and IL-6 trans-signaling. Ho M, Chen T, Liu J, Dowling P, Hideshima T, Zhang L, Morelli E, Camci-Unal G, Wu X, Tai YT, Wen K, Samur M, Schlossman RL, Mazitschek R, Kavanagh EL, Lindsay S, Harada T, McCann A, Anderson KC, O'Gorman P, Bianchi G. Leukemia. 2019 May 29. pii: 10.1038/s41375-019-0493-x. doi: 10.1038/s41375-019-0493-x. PubMed
Two human patient mitochondrial pyruvate carrier mutations reveal distinct molecular mechanisms of dysfunction. Oonthonpan L, Rauckhorst AJ, Gray LR, Boutron AC, Taylor EB. JCI Insight. 2019 May 30;5. pii: 126132. doi: 10.1172/jci.insight.126132. PubMed
Involvement of Interferon Regulatory Factor 7 in Nicotine's Suppression of Antiviral Immune Responses. Han H, Huang W, Du W, Shen Q, Yang Z, Li MD, Chang SL. J Neuroimmune Pharmacol. 2019 Jun 1. pii: 10.1007/s11481-019-09845-2. doi: 10.1007/s11481-019-09845-2. PubMed
The Poly(C) Motif in the Proximal Promoter Region of the D Site-Binding Protein Gene (Dbp) Drives Its High-Amplitude Oscillation. Kwon PK, Kim HM, Kim SW, Kang B, Yi H, Ku HO, Roh TY, Kim KT. Mol Cell Biol. 2019 Jul 29;39(16). pii: MCB.00101-19. doi: 10.1128/MCB.00101-19. Print 2019 Aug 15. PubMed
Robust hematopoietic specification requires the ubiquitous Sp1 and Sp3 transcription factors. Gilmour J, O'Connor L, Middleton CP, Keane P, Gillemans N, Cazier JB, Philipsen S, Bonifer C. Epigenetics Chromatin. 2019 Jun 4;12(1):33. doi: 10.1186/s13072-019-0282-9. PubMed
Robust CRISPR/Cas9 Genome Editing of the HUDEP-2 Erythroid Precursor Line Using Plasmids and Single-Stranded Oligonucleotide Donors. Moir-Meyer G, Cheong PL, Olijnik AA, Brown J, Knight S, King A, Kurita R, Nakamura Y, Gibbons RJ, Higgs DR, Buckle VJ, Babbs C. Methods Protoc. 2018 Jul 30;1(3). pii: mps1030028. doi: 10.3390/mps1030028. PubMed
Isoform-specific gene disruptions reveal a role for the V-ATPase subunit a4 isoform in the invasiveness of 4T1-12B breast cancer cells. McGuire CM, Collins MP, Sun-Wada G, Wada Y, Forgac M. J Biol Chem. 2019 Jul 19;294(29):11248-11258. doi: 10.1074/jbc.RA119.007713. Epub 2019 Jun 5. PubMed
Individual and combined presenilin 1 and 2 knockouts reveal that both have highly overlapping functions in HEK293T cells. Lessard CB, Rodriguez E, Ladd TB, Minter LM, Osborne BA, Miele L, Golde TE, Ran Y. J Biol Chem. 2019 Jul 19;294(29):11276-11285. doi: 10.1074/jbc.RA119.008041. Epub 2019 Jun 5. PubMed
Histone demethylase Kdm2a regulates germ cell genes and endogenous retroviruses in embryonic stem cells. Fu E, Shen J, Dong Z, Zhang W, Zhang Y, Chen F, Cheng Z, Zhao X, Shuai L, Lu X. Epigenomics. 2019 May;11(7):751-766. doi: 10.2217/epi-2018-0126. Epub 2019 Jun 7. PubMed
Seipin Facilitates Triglyceride Flow to Lipid Droplet and Counteracts Droplet Ripening via Endoplasmic Reticulum Contact. Salo VT, Li S, Vihinen H, Holtta-Vuori M, Szkalisity A, Horvath P, Belevich I, Peranen J, Thiele C, Somerharju P, Zhao H, Santinho A, Thiam AR, Jokitalo E, Ikonen E. Dev Cell. 2019 Jun 6. pii: S1534-5807(19)30388-0. doi: 10.1016/j.devcel.2019.05.016. PubMed Associated Plasmids pGL3-sgACSL3.C-Cas9-P2A-Puro pGL3-Basic-ACSL3-sfGFP(C) HDR template pGL3-Basic-Rab18-sfGFP(N) HDR template pSH-EFIRES-P-GFP(1-10)opti pGL3-sgRab18.N-Cas9-T2A-mCherry-P2A-Puro
SHOC2 phosphatase-dependent RAF dimerization mediates resistance to MEK inhibition in RAS-mutant cancers. Jones GG, Del Rio IB, Sari S, Sekerim A, Young LC, Hartig N, Areso Zubiaur I, El-Bahrawy MA, Hynds RE, Lei W, Molina-Arcas M, Downward J, Rodriguez-Viciana P. Nat Commun. 2019 Jun 10;10(1):2532. doi: 10.1038/s41467-019-10367-x. PubMed
Quantitative Interactomics in Primary T Cells Provides a Rationale for Concomitant PD-1 and BTLA Coinhibitor Blockade in Cancer Immunotherapy. Celis-Gutierrez J, Blattmann P, Zhai Y, Jarmuzynski N, Ruminski K, Gregoire C, Ounoughene Y, Fiore F, Aebersold R, Roncagalli R, Gstaiger M, Malissen B. Cell Rep. 2019 Jun 11;27(11):3315-3330.e7. doi: 10.1016/j.celrep.2019.05.041. PubMed
Spatial Chromosome Folding and Active Transcription Drive DNA Fragility and Formation of Oncogenic MLL Translocations. Gothe HJ, Bouwman BAM, Gusmao EG, Piccinno R, Petrosino G, Sayols S, Drechsel O, Minneker V, Josipovic N, Mizi A, Nielsen CF, Wagner EM, Takeda S, Sasanuma H, Hudson DF, Kindler T, Baranello L, Papantonis A, Crosetto N, Roukos V. Mol Cell. 2019 Jul 25;75(2):267-283.e12. doi: 10.1016/j.molcel.2019.05.015. Epub 2019 Jun 12. PubMed
Rebalancing Protein Homeostasis Enhances Tumor Antigen Presentation. Jaeger AM, Stopfer L, Lee S, Gaglia G, Sandel D, Santagata S, Lin NU, Trepel JB, White F, Jacks T, Lindquist S, Whitesell L. Clin Cancer Res. 2019 Jun 18. pii: 1078-0432.CCR-19-0596. doi: 10.1158/1078-0432.CCR-19-0596. PubMed
Combinatorial diversity of Syk recruitment driven by its multivalent engagement with FcepsilonRIgamma. Travers T, Kanagy WK, Mansbach RA, Jhamba E, Cleyrat C, Goldstein B, Lidke DS, Wilson BS, Gnanakaran S. Mol Biol Cell. 2019 Aug 1;30(17):2331-2347. doi: 10.1091/mbc.E18-11-0722. Epub 2019 Jun 19. PubMed
ARID1A facilitates KRAS signaling-regulated enhancer activity in an AP1-dependent manner in colorectal cancer cells. Sen M, Wang X, Hamdan FH, Rapp J, Eggert J, Kosinsky RL, Wegwitz F, Kutschat AP, Younesi FS, Gaedcke J, Grade M, Hessmann E, Papantonis A, Strbel P, Johnsen SA. Clin Epigenetics. 2019 Jun 19;11(1):92. doi: 10.1186/s13148-019-0690-5. PubMed
The Novel Avian Leukosis Virus Subgroup K Shares Its Cellular Receptor with Subgroup A. Prikryl D, Plachy J, Kucerova D, Koslova A, Reinisova M, Senigl F, Hejnar J. J Virol. 2019 Aug 13;93(17). pii: JVI.00580-19. doi: 10.1128/JVI.00580-19. Print 2019 Sep 1. PubMed
A Platform for Studying Neurodegeneration Mechanisms Using Genetically Encoded Biosensors. Ustyantseva EI, Medvedev SP, Vetchinova AS, Minina JM, Illarioshkin SN, Zakian SM. Biochemistry (Mosc). 2019 Mar;84(3):299-309. doi: 10.1134/S000629791903012X. PubMed
Genetic Deletion of GABAA Receptors Reveals Distinct Requirements of Neurotransmitter Receptors for GABAergic and Glutamatergic Synapse Development. Duan J, Pandey S, Li T, Castellano D, Gu X, Li J, Tian Q, Lu W. Front Cell Neurosci. 2019 Jun 4;13:217. doi: 10.3389/fncel.2019.00217. eCollection 2019. PubMed
An ARF6-Exportin-5 axis delivers pre-miRNA cargo to tumour microvesicles. Clancy JW, Zhang Y, Sheehan C, D'Souza-Schorey C. Nat Cell Biol. 2019 Jul;21(7):856-866. doi: 10.1038/s41556-019-0345-y. Epub 2019 Jun 24. PubMed
C/EBPbeta-LIP induces cancer-type metabolic reprogramming by regulating the let-7/LIN28B circuit in mice. Ackermann T, Hartleben G, Muller C, Mastrobuoni G, Groth M, Sterken BA, Zaini MA, Youssef SA, Zuidhof HR, Krauss SR, Kortman G, de Haan G, de Bruin A, Wang ZQ, Platzer M, Kempa S, Calkhoven CF. Commun Biol. 2019 Jun 14;2:208. doi: 10.1038/s42003-019-0461-z. eCollection 2019. PubMed
Fetal and trophoblast PI3K p110alpha have distinct roles in regulating resource supply to the growing fetus in mice. Lopez-Tello J, Perez-Garcia V, Khaira J, Kusinski LC, Cooper WN, Andreani A, Grant I, Fernandez de Liger E, Lam BY, Hemberger M, Sandovici I, Constancia M, Sferruzzi-Perri AN. Elife. 2019 Jun 26;8. pii: 45282. doi: 10.7554/eLife.45282. PubMed
CRISPR-READI: Efficient Generation of Knockin Mice by CRISPR RNP Electroporation and AAV Donor Infection. Chen S, Sun S, Moonen D, Lee C, Lee AY, Schaffer DV, He L. Cell Rep. 2019 Jun 25;27(13):3780-3789.e4. doi: 10.1016/j.celrep.2019.05.103. PubMed Associated Plasmids pscAAV-Tyr pscAAV-Sox2-mStr pAAV-Sox2-CreERT2 pAAV-R26-FLEX-mStr
Metallothionein 3 Controls the Phenotype and Metabolic Programming of Alternatively Activated Macrophages. Chowdhury D, Alrefai H, Landero Figueroa JA, Candor K, Porollo A, Fecher R, Divanovic S, Deepe GS Jr, Subramanian Vignesh K. Cell Rep. 2019 Jun 25;27(13):3873-3886.e7. doi: 10.1016/j.celrep.2019.05.093. PubMed
CRISPR/Cas9 mediated ELANE knockout enables neutrophilic maturation of primary hematopoietic stem and progenitor cells and induced pluripotent stem cells of severe congenital neutropenia patients. Nasri M, Ritter M, Mir P, Dannenmann B, Aghaallaei N, Amend D, Makaryan V, Xu Y, Fletcher B, Bernhard R, Steiert I, Hahnel K, Berger J, Koch I, Sailer B, Hipp K, Zeidler C, Klimiankou M, Bajoghli B, Dale DC, Welte K, Skokowa J. Haematologica. 2019 Jun 27. pii: haematol.2019.221804. doi: 10.3324/haematol.2019.221804. PubMed
CRISPR Base Editing in Induced Pluripotent Stem Cells. Chang YJ, Xu CL, Cui X, Bassuk AG, Mahajan VB, Tsai YT, Tsang SH. Methods Mol Biol. 2019 Jun 28. doi: 10.1007/7651_2019_243. PubMed
WDFY2 restrains matrix metalloproteinase secretion and cell invasion by controlling VAMP3-dependent recycling. Sneeggen M, Pedersen NM, Campsteijn C, Haugsten EM, Stenmark H, Schink KO. Nat Commun. 2019 Jun 28;10(1):2850. doi: 10.1038/s41467-019-10794-w. PubMed Associated Plasmids pmCherry-2xFYVE
Heterozygous loss of Srp72 in mice is not associated with major hematological phenotypes. D'Altri T, Schuster MB, Wenzel A, Porse BT. Eur J Haematol. 2019 Jun 29. doi: 10.1111/ejh.13286. PubMed
Nrf2 Activation Promotes Lung Cancer Metastasis by Inhibiting the Degradation of Bach1. Lignitto L, LeBoeuf SE, Homer H, Jiang S, Askenazi M, Karakousi TR, Pass HI, Bhutkar AJ, Tsirigos A, Ueberheide B, Sayin VI, Papagiannakopoulos T, Pagano M. Cell. 2019 Jul 11;178(2):316-329.e18. doi: 10.1016/j.cell.2019.06.003. Epub 2019 Jun 27. PubMed Associated Plasmids pcDNA3.1_ 2xFLAG-2xSTREP_FBXO22 pcDNA3.1_ 2xFLAG-2xSTREP_KEAP1 pcDNA3.1_ 2xFLAG-2xSTREP_NRF2 pcDNA3.1_ 2xFLAG-2xSTREP_BACH1 pcDNA3.1_ 2xFLAG-2xSTREP_BACH1_Y11A More ...
The E3 ubiquitin ligase RNF40 suppresses apoptosis in colorectal cancer cells. Schneider D, Chua RL, Molitor N, Hamdan FH, Rettenmeier EM, Prokakis E, Mishra VK, Kari V, Wegwitz F, Johnsen SA, Kosinsky RL. Clin Epigenetics. 2019 Jul 2;11(1):98. doi: 10.1186/s13148-019-0698-x. PubMed
Human GBP1 is a microbe-specific gatekeeper of macrophage apoptosis and pyroptosis. Fisch D, Bando H, Clough B, Hornung V, Yamamoto M, Shenoy AR, Frickel EM. EMBO J. 2019 Jul 1;38(13):e100926. doi: 10.15252/embj.2018100926. Epub 2019 Jun 3. PubMed Associated Plasmids pLenti-Tet pGene-TAP-GBP1 pLenti-Tet-GBP1-C589A
Small-Molecule Modulation of TDP-43 Recruitment to Stress Granules Prevents Persistent TDP-43 Accumulation in ALS/FTD. Fang MY, Markmiller S, Vu AQ, Javaherian A, Dowdle WE, Jolivet P, Bushway PJ, Castello NA, Baral A, Chan MY, Linsley JW, Linsley D, Mercola M, Finkbeiner S, Lecuyer E, Lewcock JW, Yeo GW. Neuron. 2019 Sep 4;103(5):802-819.e11. doi: 10.1016/j.neuron.2019.05.048. Epub 2019 Jul 1. PubMed
The antimalarial drug amodiaquine stabilizes p53 through ribosome biogenesis stress, independently of its autophagy-inhibitory activity. Espinoza JA, Zisi A, Kanellis DC, Carreras-Puigvert J, Henriksson M, Huhn D, Watanabe K, Helleday T, Lindstrom MS, Bartek J. Cell Death Differ. 2020 Feb;27(2):773-789. doi: 10.1038/s41418-019-0387-5. Epub 2019 Jul 8. PubMed
Control of biosilica morphology and mechanical performance by the conserved diatom gene Silicanin-1. Gorlich S, Pawolski D, Zlotnikov I, Kroger N. Commun Biol. 2019 Jun 28;2:245. doi: 10.1038/s42003-019-0436-0. eCollection 2019. PubMed
Caspase-2 and p75 neurotrophin receptor (p75NTR) are involved in the regulation of SREBP and lipid genes in hepatocyte cells. Pham DD, Bruelle C, Thi Do H, Pajanoja C, Jin C, Srinivasan V, Olkkonen VM, Eriksson O, Jauhiainen M, Lalowski M, Lindholm D. Cell Death Dis. 2019 Jul 11;10(7):537. doi: 10.1038/s41419-019-1758-z. PubMed
HDAC6 Inhibition Synergizes with Anti-PD-L1 Therapy in ARID1A-Inactivated Ovarian Cancer. Fukumoto T, Fatkhutdinov N, Zundell JA, Tcyganov EN, Nacarelli T, Karakashev S, Wu S, Liu Q, Gabrilovich DI, Zhang R. Cancer Res. 2019 Nov 1;79(21):5482-5489. doi: 10.1158/0008-5472.CAN-19-1302. Epub 2019 Jul 16. PubMed
The Edwardsiella piscicida thioredoxin-like protein inhibits ASK1-MAPKs signaling cascades to promote pathogenesis during infection. Yang D, Liu X, Xu W, Gu Z, Yang C, Zhang L, Tan J, Zheng X, Wang Z, Quan S, Zhang Y, Liu Q. PLoS Pathog. 2019 Jul 17;15(7):e1007917. doi: 10.1371/journal.ppat.1007917. eCollection 2019 Jul. PubMed
Identification of TMEM206 proteins as pore of PAORAC/ASOR acid-sensitive chloride channels. Ullrich F, Blin S, Lazarow K, Daubitz T, von Kries JP, Jentsch TJ. Elife. 2019 Jul 18;8. pii: 49187. doi: 10.7554/eLife.49187. PubMed
Integrated analyses of murine breast cancer models reveal critical parallels with human disease. Rennhack JP, To B, Swiatnicki M, Dulak C, Ogrodzinski MP, Zhang Y, Li C, Bylett E, Ross C, Szczepanek K, Hanrahan W, Jayatissa M, Lunt SY, Hunter K, Andrechek ER. Nat Commun. 2019 Jul 22;10(1):3261. doi: 10.1038/s41467-019-11236-3. PubMed
CRISPR/Cas9-Mediated Genetic Engineering of Hybridomas for Creation of Antibodies that Allow for Site-Specific Conjugation. Khoshnejad M, Brenner JS, Parhiz H, Muzykantov VR. Methods Mol Biol. 2019;2033:81-93. doi: 10.1007/978-1-4939-9654-4_7. PubMed
E2F1 Drives Breast Cancer Metastasis by Regulating the Target Gene FGF13 and Altering Cell Migration. Hollern DP, Swiatnicki MR, Rennhack JP, Misek SA, Matson BC, McAuliff A, Gallo KA, Caron KM, Andrechek ER. Sci Rep. 2019 Jul 24;9(1):10718. doi: 10.1038/s41598-019-47218-0. PubMed
Proximity labeling to detect RNA-protein interactions in live cells. Lu M, Wei W. FEBS Open Bio. 2019 Nov;9(11):1860-1868. doi: 10.1002/2211-5463.12706. Epub 2019 Sep 25. PubMed
Modification of messenger RNA by 2'-O-methylation regulates gene expression in vivo. Elliott BA, Ho HT, Ranganathan SV, Vangaveti S, Ilkayeva O, Abou Assi H, Choi AK, Agris PF, Holley CL. Nat Commun. 2019 Jul 30;10(1):3401. doi: 10.1038/s41467-019-11375-7. PubMed
The E3 ubiquitin ligase UBR5 interacts with the H/ACA ribonucleoprotein complex and regulates ribosomal RNA biogenesis in embryonic stem cells. Saez I, Gerbracht JV, Koyuncu S, Lee HJ, Horn M, Kroef V, Denzel MS, Dieterich C, Gehring NH, Vilchez D. FEBS Lett. 2020 Jan;594(1):175-188. doi: 10.1002/1873-3468.13559. Epub 2019 Aug 8. PubMed
Small molecule degraders of the hepatitis C virus protease reduce susceptibility to resistance mutations. de Wispelaere M, Du G, Donovan KA, Zhang T, Eleuteri NA, Yuan JC, Kalabathula J, Nowak RP, Fischer ES, Gray NS, Yang PL. Nat Commun. 2019 Aug 1;10(1):3468. doi: 10.1038/s41467-019-11429-w. PubMed
Gene-edited murine cell lines for propagation of chronic wasting disease prions. Walia R, Ho CC, Lee C, Gilch S, Schatzl HM. Sci Rep. 2019 Aug 1;9(1):11151. doi: 10.1038/s41598-019-47629-z. PubMed
Genetic Depletion of Class I Odorant Receptors Impacts Perception of Carboxylic Acids. Cichy A, Shah A, Dewan A, Kaye S, Bozza T. Curr Biol. 2019 Aug 19;29(16):2687-2697.e4. doi: 10.1016/j.cub.2019.06.085. Epub 2019 Aug 1. PubMed
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WBP11 is required for splicing the TUBGCP6 pre-mRNA to promote centriole duplication. Park EM, Scott PM, Clutario K, Cassidy KB, Zhan K, Gerber SA, Holland AJ. J Cell Biol. 2020 Jan 6;219(1). pii: 133543. doi: 10.1083/jcb.201904203. PubMed
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AAV-Mediated Gene Augmentation Therapy Restores Critical Functions in Mutant PRPF31(+/-) iPSC-Derived RPE Cells. Brydon EM, Bronstein R, Buskin A, Lako M, Pierce EA, Fernandez-Godino R. Mol Ther Methods Clin Dev. 2019 Nov 11;15:392-402. doi: 10.1016/j.omtm.2019.10.014. eCollection 2019 Dec 13. PubMed
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RNase L promotes the formation of unique ribonucleoprotein granules distinct from stress granules. Burke JM, Lester ET, Tauber D, Parker R. J Biol Chem. 2020 Feb 7;295(6):1426-1438. doi: 10.1074/jbc.RA119.011638. Epub 2020 Jan 2. PubMed
PTPN21-CDSlong isoform inhibits the response of acute lymphoblastic leukemia cells to NK-mediated lysis via the KIR/HLA-I axis. Wang H, Zhu N, Ye X, Wang L, Wang B, Shan W, Lai X, Tan Y, Fu S, Xiao H, Huang H. J Cell Biochem. 2020 Jun;121(5-6):3298-3312. doi: 10.1002/jcb.29601. Epub 2020 Jan 2. PubMed
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The Initiation of Meiotic Sex Chromosome Inactivation Sequesters DNA Damage Signaling from Autosomes in Mouse Spermatogenesis. Abe H, Alavattam KG, Hu YC, Pang Q, Andreassen PR, Hegde RS, Namekawa SH. Curr Biol. 2020 Feb 3;30(3):408-420.e5. doi: 10.1016/j.cub.2019.11.064. Epub 2020 Jan 2. PubMed
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The inducible amphisome isolates viral hemagglutinin and defends against influenza A virus infection. Omi J, Watanabe-Takahashi M, Igai K, Shimizu E, Tseng CY, Miyasaka T, Waku T, Hama S, Nakanishi R, Goto Y, Nishino Y, Miyazawa A, Natori Y, Yamashita M, Nishikawa K. Nat Commun. 2020 Jan 9;11(1):162. doi: 10.1038/s41467-019-13974-w. PubMed
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Precise editing of myostatin signal peptide by CRISPR/Cas9 increases the muscle mass of Liang Guang Small Spotted pigs. Li R, Zeng W, Ma M, Wei Z, Liu H, Liu X, Wang M, Shi X, Zeng J, Yang L, Mo D, Liu X, Chen Y, He Z. Transgenic Res. 2020 Feb;29(1):149-163. doi: 10.1007/s11248-020-00188-w. Epub 2020 Jan 11. PubMed
Lipid droplets can promote drug accumulation and activation. Dubey R, Stivala CE, Nguyen HQ, Goo YH, Paul A, Carette JE, Trost BM, Rohatgi R. Nat Chem Biol. 2020 Feb;16(2):206-213. doi: 10.1038/s41589-019-0447-7. Epub 2020 Jan 13. PubMed
Tunable light and drug induced depletion of target proteins. Deng W, Bates JA, Wei H, Bartoschek MD, Conradt B, Leonhardt H. Nat Commun. 2020 Jan 16;11(1):304. doi: 10.1038/s41467-019-14160-8. PubMed
ETV6/RUNX1 Fusion Gene Abrogation Decreases the Oncogenicity of Tumour Cells in a Preclinical Model of Acute Lymphoblastic Leukaemia. Montano A, Ordonez JL, Alonso-Perez V, Hernandez-Sanchez J, Santos S, Gonzalez T, Benito R, Garcia-Tunon I, Hernandez-Rivas JM. Cells. 2020 Jan 15;9(1). pii: cells9010215. doi: 10.3390/cells9010215. PubMed
Precise CRISPR/Cas9 editing of the NHE1 gene renders chickens resistant to the J subgroup of avian leukosis virus. Koslova A, Trefil P, Mucksova J, Reinisova M, Plachy J, Kalina J, Kucerova D, Geryk J, Krchlikova V, Lejckova B, Hejnar J. Proc Natl Acad Sci U S A. 2020 Jan 28;117(4):2108-2112. doi: 10.1073/pnas.1913827117. Epub 2020 Jan 21. PubMed
Development of a novel monoclonal antibody that binds to most HLA-A allomorphs in a conformation-dependent yet peptide-promiscuous fashion. Komatsu T, Shimizu T, Kanoh M, Miyakawa T, Satta Y, Yasukochi Y, Fujimoto R, Tada M, Machida K, Kataoka S, Udaka K. Immunogenetics. 2020 Apr;72(3):143-153. doi: 10.1007/s00251-020-01154-w. Epub 2020 Jan 22. PubMed
Longitudinal assessment of tumor development using cancer avatars derived from genetically engineered pluripotent stem cells. Koga T, Chaim IA, Benitez JA, Markmiller S, Parisian AD, Hevner RF, Turner KM, Hessenauer FM, D'Antonio M, Nguyen ND, Saberi S, Ma J, Miki S, Boyer AD, Ravits J, Frazer KA, Bafna V, Chen CC, Mischel PS, Yeo GW, Furnari FB. Nat Commun. 2020 Jan 28;11(1):550. doi: 10.1038/s41467-020-14312-1. PubMed
Phosphatidic acid regulates subcellular distribution of RA-GEFs critical for chemokine-dependent migration. Momoi Y, Nishikimi A, Du G, Kataoka T, Katagiri K. Biochem Biophys Res Commun. 2020 Apr 2;524(2):325-331. doi: 10.1016/j.bbrc.2020.01.080. Epub 2020 Jan 26. PubMed
Modeling medulloblastoma in vivo and with human cerebellar organoids. Ballabio C, Anderle M, Gianesello M, Lago C, Miele E, Cardano M, Aiello G, Piazza S, Caron D, Gianno F, Ciolfi A, Pedace L, Mastronuzzi A, Tartaglia M, Locatelli F, Ferretti E, Giangaspero F, Tiberi L. Nat Commun. 2020 Jan 29;11(1):583. doi: 10.1038/s41467-019-13989-3. PubMed Associated Plasmids pPB CAG Gfi1:FLAG-IRES-EGFP pPB CAG Cdk6 R31C-IRES-EGFP pPB CAG Otx2-IRES-EGFP pPB CAG SMARCA4-IRES-EGFP pPB CAG SMARCA4 T910M-IRES-EGFP More ...
Vaccination with CD47 deficient tumor cells elicits an antitumor immune response in mice. Li Y, Zhang M, Wang X, Liu W, Wang H, Yang YG. Nat Commun. 2020 Jan 29;11(1):581. doi: 10.1038/s41467-019-14102-4. PubMed
AIRE is induced in oral squamous cell carcinoma and promotes cancer gene expression. Nguyen CTK, Sawangarun W, Mandasari M, Morita KI, Harada H, Kayamori K, Yamaguchi A, Sakamoto K. PLoS One. 2020 Feb 3;15(2):e0222689. doi: 10.1371/journal.pone.0222689. eCollection 2020. PubMed
Loss of GFAT-1 feedback regulation activates the hexosamine pathway that modulates protein homeostasis. Ruegenberg S, Horn M, Pichlo C, Allmeroth K, Baumann U, Denzel MS. Nat Commun. 2020 Feb 4;11(1):687. doi: 10.1038/s41467-020-14524-5. PubMed
SHOX CNE9/10 Knockout in U2OS Osteosarcoma Cells and Its Effects on Cell Growth and Apoptosis. Xu XJ, Xin SJ, Mao HY, Zhang HJ, Chen LN, Li L, Bai HL, Huang HH, Shu M. Med Sci Monit. 2020 Feb 7;26:e921233. doi: 10.12659/MSM.921233. PubMed
Novel presenilin 1 and 2 double knock-out cell line for in vitro validation of PSEN1 and PSEN2 mutations. Pimenova AA, Goate AM. Neurobiol Dis. 2020 May;138:104785. doi: 10.1016/j.nbd.2020.104785. Epub 2020 Feb 4. PubMed
Pten-mediated Gsk3beta modulates the naive pluripotency maintenance in embryonic stem cells. Wang W, Lu G, Su X, Tang C, Li H, Xiong Z, Leung CK, Wong MS, Liu H, Ma JL, Cheung HH, Kung HF, Chen ZJ, Chan WY. Cell Death Dis. 2020 Feb 7;11(2):107. doi: 10.1038/s41419-020-2271-0. PubMed
Mechanical regulation of glycolysis via cytoskeleton architecture. Park JS, Burckhardt CJ, Lazcano R, Solis LM, Isogai T, Li L, Chen CS, Gao B, Minna JD, Bachoo R, DeBerardinis RJ, Danuser G. Nature. 2020 Feb 12. pii: 10.1038/s41586-020-1998-1. doi: 10.1038/s41586-020-1998-1. PubMed Associated Plasmids pLVX neo PFKP-GFP pLVX puro TRIM21-GFP pLVX puro TRIM21 C54Y - GFP pLVX neo PFKP-GFP K281R pLVX neo PFKL-GFP More ...
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Generation and analysis of novel Reln-deleted mouse model corresponding to exonic Reln deletion in schizophrenia. Sawahata M, Mori D, Arioka Y, Kubo H, Kushima I, Kitagawa K, Sobue A, Shishido E, Sekiguchi M, Kodama A, Ikeda R, Aleksic B, Kimura H, Ishizuka K, Nagai T, Kaibuchi K, Nabeshima T, Yamada K, Ozaki N. Psychiatry Clin Neurosci. 2020 May;74(5):318-327. doi: 10.1111/pcn.12993. Epub 2020 Mar 5. PubMed
Lipid Peroxidation Plays an Important Role in Chemotherapeutic Effects of Temozolomide and the Development of Therapy Resistance in Human Glioblastoma. Wu W, Wu Y, Mayer K, von Rosenstiel C, Schecker J, Baur S, Wurstle S, Liesche-Starnecker F, Gempt J, Schlegel J. Transl Oncol. 2020 Mar;13(3):100748. doi: 10.1016/j.tranon.2020.100748. Epub 2020 Feb 19. PubMed
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Desmin mutations result in mitochondrial dysfunction regardless of their aggregation properties. Smolina N, Khudiakov A, Knyazeva A, Zlotina A, Sukhareva K, Kondratov K, Gogvadze V, Zhivotovsky B, Sejersen T, Kostareva A. Biochim Biophys Acta Mol Basis Dis. 2020 Jun 1;1866(6):165745. doi: 10.1016/j.bbadis.2020.165745. Epub 2020 Feb 25. PubMed
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Follistatin is a novel therapeutic target and biomarker in FLT3/ITD acute myeloid leukemia. He BL, Yang N, Man CH, Ng NK, Cher CY, Leung HC, Kan LL, Cheng BY, Lam SS, Wang ML, Zhang CX, Kwok H, Cheng G, Sharma R, Ma AC, So CW, Kwong YL, Leung AY. EMBO Mol Med. 2020 Apr 7;12(4):e10895. doi: 10.15252/emmm.201910895. Epub 2020 Mar 5. PubMed
Neurofibromin Is an Estrogen Receptor-alpha Transcriptional Co-repressor in Breast Cancer. Zheng ZY, Anurag M, Lei JT, Cao J, Singh P, Peng J, Kennedy H, Nguyen NC, Chen Y, Lavere P, Li J, Du XH, Cakar B, Song W, Kim BJ, Shi J, Seker S, Chan DW, Zhao GQ, Chen X, Banks KC, Lanman RB, Shafaee MN, Zhang XH, Vasaikar S, Zhang B, Hilsenbeck SG, Li W, Foulds CE, Ellis MJ, Chang EC. Cancer Cell. 2020 Mar 16;37(3):387-402.e7. doi: 10.1016/j.ccell.2020.02.003. Epub 2020 Mar 5. PubMed
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Pannexin-1 mediates fluid shear stress-sensitive purinergic signaling and cyst growth in polycystic kidney disease. Verschuren EHJ, Rigalli JP, Castenmiller C, Rohrbach MU, Bindels RJM, Peters DJM, Arjona FJ, Hoenderop JGJ. FASEB J. 2020 May;34(5):6382-6398. doi: 10.1096/fj.201902901R. Epub 2020 Mar 11. PubMed
A Genome-wide ER-phagy Screen Highlights Key Roles of Mitochondrial Metabolism and ER-Resident UFMylation. Liang JR, Lingeman E, Luong T, Ahmed S, Muhar M, Nguyen T, Olzmann JA, Corn JE. Cell. 2020 Mar 19;180(6):1160-1177.e20. doi: 10.1016/j.cell.2020.02.017. Epub 2020 Mar 10. PubMed Associated Plasmids pLenti-X1-Neo-NDUFB4 pLenti-X1-Neo-NDUFB2 pLenti-X1-Neo-ATP5O pLenti-XI-Neo-GST-Constitutively Active AMPK pLenti-XI-Neo-GST- AMPK- Kinase Dead (K to R) More ...
Heterogeneous Nuclear Ribonucleoprotein L Negatively Regulates Foot-and-Mouth Disease Virus Replication through Inhibition of Viral RNA Synthesis by Interacting with the Internal Ribosome Entry Site in the 5' Untranslated Region. Sun C, Liu M, Chang J, Yang D, Zhao B, Wang H, Zhou G, Weng C, Yu L. J Virol. 2020 May 4;94(10):e00282-20. doi: 10.1128/JVI.00282-20. Print 2020 May 4. PubMed
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UBB pseudogene 4 encodes functional ubiquitin variants. Dubois ML, Meller A, Samandi S, Brunelle M, Frion J, Brunet MA, Toupin A, Beaudoin MC, Jacques JF, Levesque D, Scott MS, Lavigne P, Roucou X, Boisvert FM. Nat Commun. 2020 Mar 11;11(1):1306. doi: 10.1038/s41467-020-15090-6. PubMed
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NEAT1 is Required for the Expression of the Liver Cancer Stem Cell Marker CD44. Koyama S, Tsuchiya H, Amisaki M, Sakaguchi H, Honjo S, Fujiwara Y, Shiota G. Int J Mol Sci. 2020 Mar 11;21(6). pii: ijms21061927. doi: 10.3390/ijms21061927. PubMed
Western diet induces severe nonalcoholic steatohepatitis, ductular reaction, and hepatic fibrosis in liver CGI-58 knockout mice. Yang P, Wang Y, Tang W, Sun W, Ma Y, Lin S, Jing J, Jiang L, Shi H, Song Z, Yu L. Sci Rep. 2020 Mar 13;10(1):4701. doi: 10.1038/s41598-020-61473-6. PubMed
FAIM Is a Non-redundant Defender of Cellular Viability in the Face of Heat and Oxidative Stress and Interferes With Accumulation of Stress-Induced Protein Aggregates. Kaku H, Rothstein TL. Front Mol Biosci. 2020 Feb 27;7:32. doi: 10.3389/fmolb.2020.00032. eCollection 2020. PubMed
Biallelic loss of FAM46C triggers tumor growth with concomitant activation of Akt signaling in multiple myeloma cells. Kanasugi J, Hanamura I, Ota A, Karnan S, Lam VQ, Mizuno S, Wahiduzzaman M, Rahman ML, Hyodo T, Konishi H, Tsuzuki S, Hosokawa Y, Takami A. Cancer Sci. 2020 May;111(5):1663-1675. doi: 10.1111/cas.14386. Epub 2020 Apr 9. PubMed
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cAMP signaling primes lung endothelial cells to activate caspase-1 during Pseudomonas aeruginosa infection. Renema P, Hardy KS, Housley N, Dunbar G, Annamdevula N, Britain A, Spadafora D, Leavesley S, Rich T, Audia JP, Alvarez DF. Am J Physiol Lung Cell Mol Physiol. 2020 May 1;318(5):L1074-L1083. doi: 10.1152/ajplung.00185.2019. Epub 2020 Mar 18. PubMed
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Noncoding Variants Connect Enhancer Dysregulation with Nuclear Receptor Signaling in Hematopoietic Malignancies. Li K, Zhang Y, Liu X, Liu Y, Gu Z, Cao H, Dickerson KE, Chen M, Chen W, Shao Z, Ni M, Xu J. Cancer Discov. 2020 May;10(5):724-745. doi: 10.1158/2159-8290.CD-19-1128. Epub 2020 Mar 18. PubMed
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Use of Human Induced Pluripotent Stem Cells and Kidney Organoids To Develop a Cysteamine/mTOR Inhibition Combination Therapy for Cystinosis. Hollywood JA, Przepiorski A, D'Souza RF, Sreebhavan S, Wolvetang EJ, Harrison PT, Davidson AJ, Holm TM. J Am Soc Nephrol. 2020 May;31(5):962-982. doi: 10.1681/ASN.2019070712. Epub 2020 Mar 20. PubMed
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The Gb3-enriched CD59/flotillin plasma membrane domain regulates host cell invasion by Pseudomonas aeruginosa. Brandel A, Aigal S, Lagies S, Schlimpert M, Melendez AV, Xu M, Lehmann A, Hummel D, Fisch D, Madl J, Eierhoff T, Kammerer B, Romer W. Cell Mol Life Sci. 2021 Apr;78(7):3637-3656. doi: 10.1007/s00018-021-03766-1. Epub 2021 Feb 8. PubMed
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Cryo-EM structures of human RNA polymerase III in its unbound and transcribing states. Girbig M, Misiaszek AD, Vorlander MK, Lafita A, Grotsch H, Baudin F, Bateman A, Muller CW. Nat Struct Mol Biol. 2021 Feb;28(2):210-219. doi: 10.1038/s41594-020-00555-5. Epub 2021 Feb 8. PubMed
Unexpected redundancy of Gpr56 and Gpr97 during hematopoietic cell development and differentiation. Maglitto A, Mariani SA, de Pater E, Rodriguez-Seoane C, Vink CS, Piao X, Lukke ML, Dzierzak E. Blood Adv. 2021 Feb 9;5(3):829-842. doi: 10.1182/bloodadvances.2020003693. PubMed
NOTCH1-driven UBR7 stimulates nucleotide biosynthesis to promote T cell acute lymphoblastic leukemia. Srivastava S, Sahu U, Zhou Y, Hogan AK, Sathyan KM, Bodner J, Huang J, Wong KA, Khalatyan N, Savas JN, Ntziachristos P, Ben-Sahra I, Foltz DR. Sci Adv. 2021 Jan 27;7(5). pii: 7/5/eabc9781. doi: 10.1126/sciadv.abc9781. Print 2021 Jan. PubMed
Mutations in PRDM15 Are a Novel Cause of Galloway-Mowat Syndrome. Mann N, Mzoughi S, Schneider R, Kuhl SJ, Schanze D, Klambt V, Lovric S, Mao Y, Shi S, Tan W, Kuhl M, Onuchic-Whitford AC, Treimer E, Kitzler TM, Kause F, Schumann S, Nakayama M, Buerger F, Shril S, van der Ven AT, Majmundar AJ, Holton KM, Kolb A, Braun DA, Rao J, Jobst-Schwan T, Mildenberger E, Lennert T, Kuechler A, Wieczorek D, Gross O, Ermisch-Omran B, Werberger A, Skalej M, Janecke AR, Soliman NA, Mane SM, Lifton RP, Kadlec J, Guccione E, Schmeisser MJ, Zenker M, Hildebrandt F. J Am Soc Nephrol. 2021 Mar;32(3):580-596. doi: 10.1681/ASN.2020040490. Epub 2021 Feb 16. PubMed
A hexokinase isoenzyme switch in human liver cancer cells promotes lipogenesis and enhances innate immunity. Perrin-Cocon L, Vidalain PO, Jacquemin C, Aublin-Gex A, Olmstead K, Panthu B, Rautureau GJP, Andre P, Nyczka P, Hutt MT, Amoedo N, Rossignol R, Filipp FV, Lotteau V, Diaz O. Commun Biol. 2021 Feb 16;4(1):217. doi: 10.1038/s42003-021-01749-3. PubMed
Repression of Wnt/beta-catenin signaling by SOX9 and Mastermind-like transcriptional coactivator 2. Sinha A, Fan VB, Ramakrishnan AB, Engelhardt N, Kennell J, Cadigan KM. Sci Adv. 2021 Feb 17;7(8). pii: 7/8/eabe0849. doi: 10.1126/sciadv.abe0849. Print 2021 Feb. PubMed
WJMSC-derived small extracellular vesicle enhance T cell suppression through PD-L1. Li M, Soder R, Abhyankar S, Abdelhakim H, Braun MW, Trinidad CV, Pathak HB, Pessetto Z, Deighan C, Ganguly S, Dawn B, McGuirk J, Dunavin N, Godwin AK. J Extracell Vesicles. 2021 Feb;10(4):e12067. doi: 10.1002/jev2.12067. Epub 2021 Feb 8. PubMed
Repressing Ago2 mRNA translation by Trim71 maintains pluripotency through inhibiting let-7 microRNAs. Liu Q, Chen X, Novak MK, Zhang S, Hu W. Elife. 2021 Feb 18;10. pii: 66288. doi: 10.7554/eLife.66288. PubMed
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FOXF1 is required for the oncogenic properties of PAX3-FOXO1 in rhabdomyosarcoma. Milewski D, Shukla S, Gryder BE, Pradhan A, Donovan J, Sudha P, Vallabh S, Pyros A, Xu Y, Barski A, Szabo S, Turpin B, Pressey JG, Millay DP, Khan J, Kalinichenko VV, Kalin TV. Oncogene. 2021 Mar;40(12):2182-2199. doi: 10.1038/s41388-021-01694-9. Epub 2021 Feb 24. PubMed
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High VHL Expression Reverses Warburg Phenotype and Enhances Immunogenicity in Kidney Tumor Cells. Zhu S, Ding W, Chen Y, Wang W, Xu R, Liu C, Liu X, Deng H. Genomics Proteomics Bioinformatics. 2021 Feb 26. pii: S1672-0229(21)00039-5. doi: 10.1016/j.gpb.2019.12.002. PubMed
Comparative Analysis of Stk11/Lkb1 versus Pten Deficiency in Lung Adenocarcinoma Induced by CRISPR/Cas9. Berthelsen MF, Leknes SL, Riedel M, Pedersen MA, Joseph JV, Hager H, Vendelbo MH, Thomsen MK. Cancers (Basel). 2021 Feb 26;13(5). pii: cancers13050974. doi: 10.3390/cancers13050974. PubMed
Omnitemporal choreographies of all five STIM/Orai and IP3Rs underlie the complexity of mammalian Ca(2+) signaling. Emrich SM, Yoast RE, Xin P, Arige V, Wagner LE, Hempel N, Gill DL, Sneyd J, Yule DI, Trebak M. Cell Rep. 2021 Mar 2;34(9):108760. doi: 10.1016/j.celrep.2021.108760. PubMed
Chromosomal translocation t(11;14) and p53 deletion induced by the CRISPR/Cas9 system in normal B cell-derived iPS cells. Azami Y, Tsuyama N, Abe Y, Sugai-Takahashi M, Kudo KI, Ota A, Sivasundaram K, Muramatsu M, Shigemura T, Sasatani M, Hashimoto Y, Saji S, Kamiya K, Hanamura I, Ikezoe T, Onodera M, Sakai A. Sci Rep. 2021 Mar 4;11(1):5216. doi: 10.1038/s41598-021-84628-5. PubMed
Systematic analysis of factors that improve homologous direct repair (HDR) efficiency in CRISPR/Cas9 technique. Di Stazio M, Foschi N, Athanasakis E, Gasparini P, d'Adamo AP. PLoS One. 2021 Mar 5;16(3):e0247603. doi: 10.1371/journal.pone.0247603. eCollection 2021. PubMed
Reversal of the Inflammatory Responses in Fabry Patient iPSC-Derived Cardiovascular Endothelial Cells by CRISPR/Cas9-Corrected Mutation. Song HY, Yang YP, Chien Y, Lai WY, Lin YY, Chou SJ, Wang ML, Wang CY, Leu HB, Yu WC, Chien CS. Int J Mol Sci. 2021 Feb 27;22(5). pii: ijms22052381. doi: 10.3390/ijms22052381. PubMed
Qa-1(b) Modulates Resistance to Anti-PD-1 Immune Checkpoint Blockade in Tumors with Defects in Antigen Processing. Zhang X, Sabio E, Krishna C, Ma X, Wang J, Jiang H, Havel JJ, Chan TA. Mol Cancer Res. 2021 Jun;19(6):1076-1084. doi: 10.1158/1541-7786.MCR-20-0652. Epub 2021 Mar 5. PubMed
Inhibition of ERAD synergizes with FTS to eradicate pancreatic cancer cells. Du R, Sullivan DK, Azizian NG, Liu Y, Li Y. BMC Cancer. 2021 Mar 6;21(1):237. doi: 10.1186/s12885-021-07967-6. PubMed
Type I IFNs facilitate innate immune control of the opportunistic bacteria Burkholderia cenocepacia in the macrophage cytosol. Dorrington MG, Bradfield CJ, Lack JB, Lin B, Liang JJ, Starr T, Ernst O, Gross JL, Sun J, Miller AH, Steele-Mortimer O, Fraser IDC. PLoS Pathog. 2021 Mar 8;17(3):e1009395. doi: 10.1371/journal.ppat.1009395. eCollection 2021 Mar. PubMed
AKT-dependent signaling of extracellular cues through telomeres impact on tumorigenesis. Sanchez-Vazquez R, Martinez P, Blasco MA. PLoS Genet. 2021 Mar 9;17(3):e1009410. doi: 10.1371/journal.pgen.1009410. eCollection 2021 Mar. PubMed
Bi-allelic MCM10 variants associated with immune dysfunction and cardiomyopathy cause telomere shortening. Baxley RM, Leung W, Schmit MM, Matson JP, Yin L, Oram MK, Wang L, Taylor J, Hedberg J, Rogers CB, Harvey AJ, Basu D, Taylor JC, Pagnamenta AT, Dreau H, Craft J, Ormondroyd E, Watkins H, Hendrickson EA, Mace EM, Orange JS, Aihara H, Stewart GS, Blair E, Cook JG, Bielinsky AK. Nat Commun. 2021 Mar 12;12(1):1626. doi: 10.1038/s41467-021-21878-x. PubMed
Wdhd1 is essential for early mouse embryogenesis. Fan HH, Lee KH, Chen YT, Lin LJ, Yang TL, Lin SW, Yu IS. Biochim Biophys Acta Mol Cell Res. 2021 May;1868(6):119011. doi: 10.1016/j.bbamcr.2021.119011. Epub 2021 Mar 11. PubMed
SILAC-based complexome profiling dissects the structural organization of the human respiratory supercomplexes in SCAFI(KO) cells. Fernandez-Vizarra E, Lopez-Calcerrada S, Formosa LE, Perez-Perez R, Ding S, Fearnley IM, Arenas J, Martin MA, Zeviani M, Ryan MT, Ugalde C. Biochim Biophys Acta Bioenerg. 2021 Jul 1;1862(7):148414. doi: 10.1016/j.bbabio.2021.148414. Epub 2021 Mar 13. PubMed
Amino acids-Rab1A-mTORC1 signaling controls whole-body glucose homeostasis. Zhang X, Wang X, Yuan Z, Radford SJ, Liu C, Libutti SK, Zheng XFS. Cell Rep. 2021 Mar 16;34(11):108830. doi: 10.1016/j.celrep.2021.108830. PubMed
A genome-wide CRISPR screen identifies UFMylation and TRAMP-like complexes as host factors required for hepatitis A virus infection. Kulsuptrakul J, Wang R, Meyers NL, Ott M, Puschnik AS. Cell Rep. 2021 Mar 16;34(11):108859. doi: 10.1016/j.celrep.2021.108859. PubMed
A non-canonical function for Centromere-associated protein-E controls centrosome integrity and orientation of cell division. Owa M, Dynlacht B. Commun Biol. 2021 Mar 19;4(1):358. doi: 10.1038/s42003-021-01861-4. PubMed
Deletion of the XIST promoter from the human inactive X chromosome compromises polycomb heterochromatin maintenance. Westervelt N, Yoest A, Sayed S, Von Zimmerman M, Kaps K, Chadwick BP. Chromosoma. 2021 Sep;130(2-3):177-197. doi: 10.1007/s00412-021-00754-z. Epub 2021 Mar 21. PubMed
mTORC1 stimulates cell growth through SAM synthesis and m(6)A mRNA-dependent control of protein synthesis. Villa E, Sahu U, O'Hara BP, Ali ES, Helmin KA, Asara JM, Gao P, Singer BD, Ben-Sahra I. Mol Cell. 2021 May 20;81(10):2076-2093.e9. doi: 10.1016/j.molcel.2021.03.009. Epub 2021 Mar 22. PubMed
SH3BP4 promotes neuropilin-1 and alpha5-integrin endocytosis and is inhibited by Akt. Burckhardt CJ, Minna JD, Danuser G. Dev Cell. 2021 Apr 19;56(8):1164-1181.e12. doi: 10.1016/j.devcel.2021.03.009. Epub 2021 Mar 23. PubMed
Targeting the Aryl Hydrocarbon Receptor Signaling Pathway in Breast Cancer Development. Vogel CFA, Lazennec G, Kado SY, Dahlem C, He Y, Castaneda A, Ishihara Y, Vogeley C, Rossi A, Haarmann-Stemmann T, Jugan J, Mori H, Borowsky AD, La Merrill MA, Sweeney C. Front Immunol. 2021 Mar 8;12:625346. doi: 10.3389/fimmu.2021.625346. eCollection 2021. PubMed
The deubiquitinase Usp9x regulates PRC2-mediated chromatin reprogramming during mouse development. Macrae TA, Ramalho-Santos M. Nat Commun. 2021 Mar 25;12(1):1865. doi: 10.1038/s41467-021-21910-0. PubMed Associated Plasmids pEF1a-Usp9x_CD-mCherry
Evolution and insights into the structure and function of the DedA superfamily containing TMEM41B and VMP1. Okawa F, Hama Y, Zhang S, Morishita H, Yamamoto H, Levine TP, Mizushima N. J Cell Sci. 2021 Apr 15;134(8). pii: 237813. doi: 10.1242/jcs.255877. Epub 2021 Apr 28. PubMed Associated Plasmids pMRX-IP-GFP-LC3-mRuby3
Transgenic mice with an R342X mutation in Phf6 display clinical features of Borjeson-Forssman-Lehmann Syndrome. Ahmed R, Sarwar S, Hu J, Cardin V, Qiu LR, Zapata G, Vandeleur L, Yan K, Lerch JP, Corbett MA, Gecz J, Picketts DJ. Hum Mol Genet. 2021 May 12;30(7):575-594. doi: 10.1093/hmg/ddab081. PubMed
ATG4 family proteins drive phagophore growth independently of the LC3/GABARAP lipidation system. Nguyen TN, Padman BS, Zellner S, Khuu G, Uoselis L, Lam WK, Skulsuppaisarn M, Lindblom RSJ, Watts EM, Behrends C, Lazarou M. Mol Cell. 2021 May 6;81(9):2013-2030.e9. doi: 10.1016/j.molcel.2021.03.001. Epub 2021 Mar 26. PubMed
Overlapping roles of JIP3 and JIP4 in promoting axonal transport of lysosomes in human iPSC-derived neurons. Gowrishankar S, Lyons L, Rafiq NM, Roczniak-Ferguson A, De Camilli P, Ferguson SM. Mol Biol Cell. 2021 May 15;32(11):1094-1103. doi: 10.1091/mbc.E20-06-0382. Epub 2021 Mar 31. PubMed
PPP6C negatively regulates oncogenic ERK signaling through dephosphorylation of MEK. Cho E, Lou HJ, Kuruvilla L, Calderwood DA, Turk BE. Cell Rep. 2021 Mar 30;34(13):108928. doi: 10.1016/j.celrep.2021.108928. PubMed
Integrated requirement of non-specific and sequence-specific DNA binding in Myc-driven transcription. Pellanda P, Dalsass M, Filipuzzi M, Loffreda A, Verrecchia A, Castillo Cano V, Thabussot H, Doni M, Morelli MJ, Soucek L, Kress T, Mazza D, Mapelli M, Beaulieu ME, Amati B, Sabo A. EMBO J. 2021 May 17;40(10):e105464. doi: 10.15252/embj.2020105464. Epub 2021 Apr 1. PubMed
A Cystine-Cysteine Intercellular Shuttle Prevents Ferroptosis in xCT(KO) Pancreatic Ductal Adenocarcinoma Cells. Meira W, Daher B, Parks SK, Cormerais Y, Durivault J, Tambutte E, Pouyssegur J, Vucetic M. Cancers (Basel). 2021 Mar 21;13(6). pii: cancers13061434. doi: 10.3390/cancers13061434. PubMed
Evaluation of AXIN1 and AXIN2 as targets of tankyrase inhibition in hepatocellular carcinoma cell lines. Wang W, Liu P, Lavrijsen M, Li S, Zhang R, Li S, van de Geer WS, van de Werken HJG, Peppelenbosch MP, Smits R. Sci Rep. 2021 Apr 2;11(1):7470. doi: 10.1038/s41598-021-87091-4. PubMed
Critical role of SMG7 in activation of the ATR-CHK1 axis in response to genotoxic stress. Ho K, Luo H, Zhu W, Tang Y. Sci Rep. 2021 Apr 5;11(1):7502. doi: 10.1038/s41598-021-86957-x. PubMed
Liquid-like protein interactions catalyse assembly of endocytic vesicles. Day KJ, Kago G, Wang L, Richter JB, Hayden CC, Lafer EM, Stachowiak JC. Nat Cell Biol. 2021 Apr;23(4):366-376. doi: 10.1038/s41556-021-00646-5. Epub 2021 Apr 5. PubMed
ATP6V0A1 encoding the a1-subunit of the V0 domain of vacuolar H(+)-ATPases is essential for brain development in humans and mice. Aoto K, Kato M, Akita T, Nakashima M, Mutoh H, Akasaka N, Tohyama J, Nomura Y, Hoshino K, Ago Y, Tanaka R, Epstein O, Ben-Haim R, Heyman E, Miyazaki T, Belal H, Takabayashi S, Ohba C, Takata A, Mizuguchi T, Miyatake S, Miyake N, Fukuda A, Matsumoto N, Saitsu H. Nat Commun. 2021 Apr 8;12(1):2107. doi: 10.1038/s41467-021-22389-5. PubMed
Silencing of LINE-1 retrotransposons is a selective dependency of myeloid leukemia. Gu Z, Liu Y, Zhang Y, Cao H, Lyu J, Wang X, Wylie A, Newkirk SJ, Jones AE, Lee M Jr, Botten GA, Deng M, Dickerson KE, Zhang CC, An W, Abrams JM, Xu J. Nat Genet. 2021 May;53(5):672-682. doi: 10.1038/s41588-021-00829-8. Epub 2021 Apr 8. PubMed
Mitochondrial NADP(+) is essential for proline biosynthesis during cell growth. Tran DH, Kesavan R, Rion H, Soflaee MH, Solmonson A, Bezwada D, Vu HS, Cai F, Phillips JA 3rd, DeBerardinis RJ, Hoxhaj G. Nat Metab. 2021 Apr;3(4):571-585. doi: 10.1038/s42255-021-00374-y. Epub 2021 Apr 8. PubMed
SOX4 and SMARCA4 cooperatively regulate PI3k signaling through transcriptional activation of TGFBR2. Mehta GA, Angus SP, Khella CA, Tong K, Khanna P, Dixon SAH, Verzi MP, Johnson GL, Gatza ML. NPJ Breast Cancer. 2021 Apr 9;7(1):40. doi: 10.1038/s41523-021-00248-2. PubMed
Tau aggregates are RNA-protein assemblies that mislocalize multiple nuclear speckle components. Lester E, Ooi FK, Bakkar N, Ayers J, Woerman AL, Wheeler J, Bowser R, Carlson GA, Prusiner SB, Parker R. Neuron. 2021 May 19;109(10):1675-1691.e9. doi: 10.1016/j.neuron.2021.03.026. Epub 2021 Apr 12. PubMed
EFA6B regulates a stop signal for collective invasion in breast cancer. Fayad R, Rojas MV, Partisani M, Finetti P, Dib S, Abelanet S, Virolle V, Farina A, Cabaud O, Lopez M, Birnbaum D, Bertucci F, Franco M, Luton F. Nat Commun. 2021 Apr 13;12(1):2198. doi: 10.1038/s41467-021-22522-4. PubMed
RSU-1 interaction with prohibitin-2 links cell-extracellular matrix detachment to downregulation of ERK signaling. Wang M, Liu J, Tu Y, Zhao Z, Qu J, Chen K, Chen Y, Sun Y, Zhao H, Deng Y, Wu C. J Biol Chem. 2021 Jan-Jun;296:100109. doi: 10.1074/jbc.RA120.014413. Epub 2020 Dec 3. PubMed
CRL4(AMBRA1) is a master regulator of D-type cyclins. Simoneschi D, Rona G, Zhou N, Jeong YT, Jiang S, Milletti G, Arbini AA, O'Sullivan A, Wang AA, Nithikasem S, Keegan S, Siu Y, Cianfanelli V, Maiani E, Nazio F, Cecconi F, Boccalatte F, Fenyo D, Jones DR, Busino L, Pagano M. Nature. 2021 Apr;592(7856):789-793. doi: 10.1038/s41586-021-03445-y. Epub 2021 Apr 14. PubMed Associated Plasmids pBABE-MCS(extended)-Puro (empty vector) pcDNA3.1-2xFLAG-2xSTREP (empty vector) pcDNA3.1-AMBRA1-3xFLAG px459-AMBRA1 #3 px458-AMBRA1 #3 More ...
DUSP16 promotes cancer chemoresistance through regulation of mitochondria-mediated cell death. Low HB, Wong ZL, Wu B, Kong LR, Png CW, Cho YL, Li CW, Xiao F, Xin X, Yang H, Loo JM, Lee FYX, Tan IBH, DasGupta R, Shen HM, Schwarz H, Gascoigne NRJ, Goh BC, Xu X, Zhang Y. Nat Commun. 2021 Apr 16;12(1):2284. doi: 10.1038/s41467-021-22638-7. PubMed
Alternative splicing redefines landscape of commonly mutated genes in acute myeloid leukemia. Rivera OD, Mallory MJ, Quesnel-Vallieres M, Chatrikhi R, Schultz DC, Carroll M, Barash Y, Cherry S, Lynch KW. Proc Natl Acad Sci U S A. 2021 Apr 13;118(15). pii: 2014967118. doi: 10.1073/pnas.2014967118. PubMed
Optic atrophy-associated TMEM126A is an assembly factor for the ND4-module of mitochondrial complex I. Formosa LE, Reljic B, Sharpe AJ, Hock DH, Muellner-Wong L, Stroud DA, Ryan MT. Proc Natl Acad Sci U S A. 2021 Apr 27;118(17). pii: 2019665118. doi: 10.1073/pnas.2019665118. PubMed
Co-regulation and function of FOXM1/RHNO1 bidirectional genes in cancer. Barger CJ, Chee L, Albahrani M, Munoz-Trujillo C, Boghean L, Branick C, Odunsi K, Drapkin R, Zou L, Karpf AR. Elife. 2021 Apr 23;10. pii: 55070. doi: 10.7554/eLife.55070. PubMed Associated Plasmids pCW57-GFP-P2A-MCS (Neo) pCW57-RFP-P2A-MCS (Neo) lentiSAM v2 (Puro) lentiMPH v2 (Neo)
iPSC modeling of stage-specific leukemogenesis reveals BAALC as a key oncogene in severe congenital neutropenia. Dannenmann B, Klimiankou M, Oswald B, Solovyeva A, Mardan J, Nasri M, Ritter M, Zahabi A, Arreba-Tutusaus P, Mir P, Stein F, Kandabarau S, Lachmann N, Moritz T, Morishima T, Konantz M, Lengerke C, Ripperger T, Steinemann D, Erlacher M, Niemeyer CM, Zeidler C, Welte K, Skokowa J. Cell Stem Cell. 2021 May 6;28(5):906-922.e6. doi: 10.1016/j.stem.2021.03.023. Epub 2021 Apr 23. PubMed
Convergence of mammalian RQC and C-end rule proteolytic pathways via alanine tailing. Thrun A, Garzia A, Kigoshi-Tansho Y, Patil PR, Umbaugh CS, Dallinger T, Liu J, Kreger S, Patrizi A, Cox GA, Tuschl T, Joazeiro CAP. Mol Cell. 2021 May 20;81(10):2112-2122.e7. doi: 10.1016/j.molcel.2021.03.004. Epub 2021 Apr 27. PubMed
Regulation of B Lymphocyte Development by Histone H2A Deubiquitinase BAP1. Lin YH, Liang Y, Wang H, Tung LT, Forster M, Subramani PG, Di Noia JM, Clare S, Langlais D, Nijnik A. Front Immunol. 2021 Apr 12;12:626418. doi: 10.3389/fimmu.2021.626418. eCollection 2021. PubMed
LRP10 interacts with SORL1 in the intracellular vesicle trafficking pathway in non-neuronal brain cells and localises to Lewy bodies in Parkinson's disease and dementia with Lewy bodies. Grochowska MM, Carreras Mascaro A, Boumeester V, Natale D, Breedveld GJ, Geut H, van Cappellen WA, Boon AJW, Kievit AJA, Sammler E, Parchi P, Cortelli P, Alessi DR, van de Berg WDJ, Bonifati V, Mandemakers W. Acta Neuropathol. 2021 Jul;142(1):117-137. doi: 10.1007/s00401-021-02313-3. Epub 2021 Apr 28. PubMed
Candidate Alzheimer's Disease Biomarker miR-483-5p Lowers TAU Phosphorylation by Direct ERK1/2 Repression. Nagaraj S, Want A, Laskowska-Kaszub K, Fesiuk A, Vaz S, Logarinho E, Wojda U. Int J Mol Sci. 2021 Apr 1;22(7). pii: ijms22073653. doi: 10.3390/ijms22073653. PubMed
Genetic Inactivation of Peroxiredoxin-I Impairs the Growth of Human Pancreatic Cancer Cells. Dahou H, Minati MA, Jacquemin P, Assi M. Antioxidants (Basel). 2021 Apr 8;10(4). pii: antiox10040570. doi: 10.3390/antiox10040570. PubMed
Feedback-Driven Mechanisms Between Phosphorylated Caveolin-1 and Contractile Actin Assemblies Instruct Persistent Cell Migration. Shi X, Wen Z, Wang Y, Liu YJ, Shi K, Jiu Y. Front Cell Dev Biol. 2021 Apr 12;9:665919. doi: 10.3389/fcell.2021.665919. eCollection 2021. PubMed
TMEM41B and VMP1 are scramblases and regulate the distribution of cholesterol and phosphatidylserine. Li YE, Wang Y, Du X, Zhang T, Mak HY, Hancock SE, McEwen H, Pandzic E, Whan RM, Aw YC, Lukmantara IE, Yuan Y, Dong X, Don A, Turner N, Qi S, Yang H. J Cell Biol. 2021 Jun 7;220(6). pii: 212020. doi: 10.1083/jcb.202103105. PubMed
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ChIP-Sequencing of TET Proteins. Rasmussen KD, Helin K. Methods Mol Biol. 2021;2272:251-262. doi: 10.1007/978-1-0716-1294-1_15. PubMed
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MPP8 is essential for sustaining self-renewal of ground-state pluripotent stem cells. Muller I, Moroni AS, Shlyueva D, Sahadevan S, Schoof EM, Radzisheuskaya A, Hojfeldt JW, Tatar T, Koche RP, Huang C, Helin K. Nat Commun. 2021 May 24;12(1):3034. doi: 10.1038/s41467-021-23308-4. PubMed Associated Plasmids pRepair-MPP8_mAID-P2A-BFP pL-U6-sgRNA-SFFV-Puro-P2A-EGFP pPB-MPP8_Flag2-Blast pPB-MPP8-112–858_Flag2-Blast pPB-MPP8-1–729_Flag2-Blast More ...
Orphan nuclear receptor COUP-TFII enhances myofibroblast glycolysis leading to kidney fibrosis. Li L, Galichon P, Xiao X, Figueroa-Ramirez AC, Tamayo D, Lee JJ, Kalocsay M, Gonzalez-Sanchez D, Chancay MS, McCracken KW, Lee NN, Ichimura T, Mori Y, Valerius MT, Wilflingseder J, Lemos DR, Edelman ER, Bonventre JV. EMBO Rep. 2021 Jun 4;22(6):e51169. doi: 10.15252/embr.202051169. Epub 2021 May 25. PubMed
CD52 is a novel target for the treatment of FLT3-ITD-mutated myeloid leukemia. Karnan S, Hanamura I, Ota A, Takasugi S, Nakamura A, Takahashi M, Uchino K, Murakami S, Wahiduzzaman M, Quang Vu L, Rahman ML, Hasan MN, Hyodo T, Konishi H, Tsuzuki S, Yoshikawa K, Suzuki S, Ueda R, Ejiri M, Hosokawa Y, Takami A. Cell Death Discov. 2021 May 25;7(1):121. doi: 10.1038/s41420-021-00446-8. PubMed
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LEDGF/p75 Is Required for an Efficient DNA Damage Response. Liedtke V, Schroder C, Roggenbuck D, Weiss R, Stohwasser R, Schierack P, Rodiger S, Schenk L. Int J Mol Sci. 2021 May 30;22(11). pii: ijms22115866. doi: 10.3390/ijms22115866. PubMed
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Generation of disease-specific and CRISPR/Cas9-mediated gene-corrected iPS cells from a patient with adult progeria Werner syndrome. Kato H, Maezawa Y, Ouchi Y, Takayama N, Sone M, Sone K, Takada-Watanabe A, Tsujimura K, Koshizaka M, Nagasawa S, Saitoh H, Ohtaka M, Nakanishi M, Tahara H, Shimamoto A, Iwama A, Eto K, Yokote K. Stem Cell Res. 2021 May;53:102360. doi: 10.1016/j.scr.2021.102360. Epub 2021 Apr 23. PubMed
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The phosphatase Shp1 interacts with and dephosphorylates cortactin to inhibit invadopodia function. Varone A, Amoruso C, Monti M, Patheja M, Greco A, Auletta L, Zannetti A, Corda D. Cell Commun Signal. 2021 Jun 4;19(1):64. doi: 10.1186/s12964-021-00747-6. PubMed
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The Dickkopf1 and FOXM1 positive feedback loop promotes tumor growth in pancreatic and esophageal cancers. Kimura H, Sada R, Takada N, Harada A, Doki Y, Eguchi H, Yamamoto H, Kikuchi A. Oncogene. 2021 Jul;40(26):4486-4502. doi: 10.1038/s41388-021-01860-z. Epub 2021 Jun 11. PubMed
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Initiation of Otx2 expression in the developing mouse retina requires a unique enhancer and either Ascl1 or Neurog2 activity. Kaufman ML, Goodson NB, Park KU, Schwanke M, Office E, Schneider SR, Abraham J, Hensley A, Jones KL, Brzezinski JA. Development. 2021 Jun 15;148(12). pii: 269198. doi: 10.1242/dev.199399. Epub 2021 Jun 18. PubMed Associated Plasmids pMin-DHS-4D-GFP pX458-Ef1a-Cas9-H2B-GFP pX458-Ef1a-Cas9-H2B-mCherry pX458-Ef1a-Cas9-GFP (gRNA: Ascl1-1) pX458-Ef1a-Cas9-GFP (gRNA: Ascl1-2) More ...
Olfactory expression of trace amine-associated receptors requires cooperative cis-acting enhancers. Shah A, Ratkowski M, Rosa A, Feinstein P, Bozza T. Nat Commun. 2021 Jun 18;12(1):3797. doi: 10.1038/s41467-021-23824-3. PubMed
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Validating TDP1 as an Inhibition Target for the Development of Chemosensitizers for Camptothecin-Based Chemotherapy Drugs. Leung E, Patel J, Hollywood JA, Zafar A, Tomek P, Barker D, Pilkington LI, van Rensburg M, Langley RJ, Helsby NA, Squire CJ, Baguley BC, Denny WA, Reynisson J, Leung IKH. Oncol Ther. 2021 Jun 23. pii: 10.1007/s40487-021-00158-0. doi: 10.1007/s40487-021-00158-0. PubMed
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Cysteamine-bicalutamide combination therapy corrects proximal tubule phenotype in cystinosis. Jamalpoor A, van Gelder CA, Yousef Yengej FA, Zaal EA, Berlingerio SP, Veys KR, Pou Casellas C, Voskuil K, Essa K, Ammerlaan CM, Rega LR, van der Welle RE, Lilien MR, Rookmaaker MB, Clevers H, Klumperman J, Levtchenko E, Berkers CR, Verhaar MC, Altelaar M, Masereeuw R, Janssen MJ. EMBO Mol Med. 2021 Jul 7;13(7):e13067. doi: 10.15252/emmm.202013067. Epub 2021 Jun 24. PubMed
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A first-in-class Polymerase Theta Inhibitor selectively targets Homologous-Recombination-Deficient Tumors. Zhou J, Gelot C, Pantelidou C, Li A, Yucel H, Davis RE, Farkkila A, Kochupurakkal B, Syed A, Shapiro GI, Tainer JA, Blagg BSJ, Ceccaldi R, D'Andrea AD. Nat Cancer. 2021 Jun;2(6):598-610. doi: 10.1038/s43018-021-00203-x. Epub 2021 Jun 17. PubMed
Locus-specific transcription silencing at the FHIT gene suppresses replication stress-induced copy number variant formation and associated replication delay. Park SH, Bennett-Baker P, Ahmed S, Arlt MF, Ljungman M, Glover TW, Wilson TE. Nucleic Acids Res. 2021 Jul 21;49(13):7507-7524. doi: 10.1093/nar/gkab559. PubMed
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The Stress-Inducible BCL2A1 Is Required for Ovarian Cancer Metastatic Progression in the Peritoneal Microenvironment. Liang R, Yung MMH, He F, Jiao P, Chan KKL, Ngan HYS, Chan DW. Cancers (Basel). 2021 Sep 12;13(18). pii: cancers13184577. doi: 10.3390/cancers13184577. PubMed
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Transcription-coupled repair of DNA-protein cross-links depends on CSA and CSB. Carnie CJ, Acampora AC, Bader AS, Erdenebat C, Zhao S, Bitensky E, van den Heuvel D, Parnas A, Gupta V, D'Alessandro G, Sczaniecka-Clift M, Weickert P, Aygenli F, Gotz MJ, Cordes J, Esain-Garcia I, Melidis L, Wondergem AP, Lam S, Robles MS, Balasubramanian S, Adar S, Luijsterburg MS, Jackson SP, Stingele J. Nat Cell Biol. 2024 May;26(5):797-810. doi: 10.1038/s41556-024-01391-1. Epub 2024 Apr 10. PubMed
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GDF-15 Suppresses Puromycin Aminonucleoside-Induced Podocyte Injury by Reducing Endoplasmic Reticulum Stress and Glomerular Inflammation. von Rauchhaupt E, Klaus M, Ribeiro A, Honarpisheh M, Li C, Liu M, Kohler P, Adamowicz K, Schmaderer C, Lindenmeyer M, Steiger S, Anders HJ, Lech M. Cells. 2024 Apr 5;13(7):637. doi: 10.3390/cells13070637. PubMed
A regulatory variant impacting TBX1 expression contributes to basicranial morphology in Homo sapiens. Funato N, Heliovaara A, Boeckx C. Am J Hum Genet. 2024 May 2;111(5):939-953. doi: 10.1016/j.ajhg.2024.03.012. Epub 2024 Apr 11. PubMed
The long non-coding RNA Meg3 mediates imprinted gene expression during stem cell differentiation. Farhadova S, Ghousein A, Charon F, Surcis C, Gomez-Velazques M, Roidor C, Di Michele F, Borensztein M, De Sario A, Esnault C, Noordermeer D, Moindrot B, Feil R. Nucleic Acids Res. 2024 Jun 24;52(11):6183-6200. doi: 10.1093/nar/gkae247. PubMed
DAZL regulate germline, pluripotency, and proliferation related genes in chicken PGCs and cooperate with DDX4. Huang Z, Xie L, Feng H, Lan M, Xu T, Chen D, Pu L, Lu Y. Theriogenology. 2024 Jul 1;222:22-30. doi: 10.1016/j.theriogenology.2024.03.010. Epub 2024 Mar 29. PubMed
RAD52-dependent mitotic DNA synthesis is required for genome stability in Cyclin E1-overexpressing cells. Audrey A, Kok YP, Yu S, de Haan L, van de Kooij B, van den Tempel N, Chen M, de Boer HR, van der Vegt B, van Vugt MATM. Cell Rep. 2024 Apr 23;43(4):114116. doi: 10.1016/j.celrep.2024.114116. Epub 2024 Apr 15. PubMed
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STMND1 is a phylogenetically ancient stathmin which localizes to motile cilia and exhibits nuclear translocation that is inhibited when soluble tubulin concentration increases. Deng X, Seguinot BO, Bradshaw G, Lee JS, Coy S, Kalocsay M, Santagata S, Mitchison T. Mol Biol Cell. 2024 Jun 1;35(6):ar82. doi: 10.1091/mbc.E23-12-0514. Epub 2024 Apr 17. PubMed
Parkinsonism Sac domain mutation in Synaptojanin-1 affects ciliary properties in iPSC-derived dopaminergic neurons. Mohd Rafiq N, Fujise K, Rosenfeld MS, Xu P, De Camilli P. Proc Natl Acad Sci U S A. 2024 Apr 23;121(17):e2318943121. doi: 10.1073/pnas.2318943121. Epub 2024 Apr 18. PubMed Associated Plasmids pmCherry-Synaptojanin-1-145 EGFP-INPP5E
Mesenchymal Stromal Cells Increase the Natural Killer Resistance of Circulating Tumor Cells via Intercellular Signaling of cGAS-STING-IFNbeta-HLA. Yi Y, Qin G, Yang H, Jia H, Zeng Q, Zheng D, Ye S, Zhang Z, Liu TM, Luo KQ, Deng CX, Xu RH. Adv Sci (Weinh). 2024 Jun;11(21):e2400888. doi: 10.1002/advs.202400888. Epub 2024 Apr 18. PubMed
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TNFR1 Absence Is Not Crucial for Different Types of Cell Reaction to TNF: A Study of the TNFR1-Knockout Cell Model. Alshevskaya AA, Lopatnikova JA, Zhukova JV, Perik-Zavodskaia OY, Alrhmoun S, Obleukhova IA, Matveeva AK, Savenkova DA, Imatdinov IR, Yudkin DV, Sennikov SV. Epigenomes. 2024 Apr 3;8(2):15. doi: 10.3390/epigenomes8020015. PubMed
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Platinum-induced upregulation of ITGA6 promotes chemoresistance and spreading in ovarian cancer. Gambelli A, Nespolo A, Rampioni Vinciguerra GL, Pivetta E, Pellarin I, Nicoloso MS, Scapin C, Stefenatti L, Segatto I, Favero A, D'Andrea S, Mucignat MT, Bartoletti M, Lucia E, Schiappacassi M, Spessotto P, Canzonieri V, Giorda G, Puglisi F, Vecchione A, Belletti B, Sonego M, Baldassarre G. EMBO Mol Med. 2024 May;16(5):1162-1192. doi: 10.1038/s44321-024-00069-3. Epub 2024 Apr 24. PubMed
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Detection of ER Stress in iPSC-Derived Neurons Carrying the p.N370S Mutation in the GBA1 Gene. Yarkova ES, Grigor'eva EV, Medvedev SP, Tarasevich DA, Pavlova SV, Valetdinova KR, Minina JM, Zakian SM, Malakhova AA. Biomedicines. 2024 Mar 27;12(4):744. doi: 10.3390/biomedicines12040744. PubMed
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The MYCN oncoprotein is an RNA-binding accessory factor of the nuclear exosome targeting complex. Papadopoulos D, Ha SA, Fleischhauer D, Uhl L, Russell TJ, Mikicic I, Schneider K, Brem A, Valanju OR, Cossa G, Gallant P, Schuelein-Voelk C, Maric HM, Beli P, Buchel G, Vos SM, Eilers M. Mol Cell. 2024 Jun 6;84(11):2070-2086.e20. doi: 10.1016/j.molcel.2024.04.007. Epub 2024 May 3. PubMed
SUMOylated Golgin45 associates with PML-NB to transcriptionally regulate lipid metabolism genes during heat shock stress. Jing S, Gao J, Tiwari N, Du Y, Zhu L, Gim B, Qian Y, Yue X, Lee I. Commun Biol. 2024 May 6;7(1):532. doi: 10.1038/s42003-024-06232-3. PubMed
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Reduction of Filamin C Results in Altered Proteostasis, Cardiomyopathy, and Arrhythmias. Ohiri JC, Dellefave-Castillo L, Tomar G, Wilsbacher L, Choudhury L, Barefield DY, Fullenkamp D, Gacita AM, Monroe TO, Pesce L, Blancard M, Vaught L, George AL Jr, Demonbreun AR, Puckelwartz MJ, McNally EM. J Am Heart Assoc. 2024 May 21;13(10):e030467. doi: 10.1161/JAHA.123.030467. Epub 2024 May 18. PubMed
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Molecular and cellular context influences SCN8A variant function. Vanoye CG, Abramova TV, DeKeyser JM, Ghabra NF, Oudin MJ, Burge CB, Helbig I, Thompson CH, George AL Jr. JCI Insight. 2024 May 21;9(12):e177530. doi: 10.1172/jci.insight.177530. PubMed Associated Plasmids pcDNA4TO-SCN8A-Variant-3-IRES-mScarlet
KAT8 compound inhibition inhibits the initial steps of PINK1-dependant mitophagy. de Talhouet C, Esteras N, Soutar MPM, O'Callaghan B, Plun-Favreau H. Sci Rep. 2024 May 22;14(1):11721. doi: 10.1038/s41598-024-60602-9. PubMed
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The GPI-anchor biosynthesis pathway is critical for syncytiotrophoblast differentiation and placental development. Alvarez-Sanchez A, Grinat J, Doria-Borrell P, Mellado-Lopez M, Pedrera-Alcocer E, Malenchini M, Meseguer S, Hemberger M, Perez-Garcia V. Cell Mol Life Sci. 2024 May 31;81(1):246. doi: 10.1007/s00018-024-05284-2. PubMed
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Reduced Protein Import via TIM23 SORT Drives Disease Pathology in TIMM50-Associated Mitochondrial Disease. Crameri JJ, Palmer CS, Stait T, Jackson TD, Lynch M, Sinclair A, Frajman LE, Compton AG, Coman D, Thorburn DR, Frazier AE, Stojanovski D. Mol Cell Biol. 2024;44(6):226-244. doi: 10.1080/10985549.2024.2353652. Epub 2024 Jun 3. PubMed
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