Skip to main content
This website uses cookies to ensure you get the best experience. By continuing to use this site, you agree to the use of cookies.

Addgene is operating at a reduced capacity.

  • Pending order? We will email to confirm that your organization can accept shipments.
  • Conducting coronavirus or COVID-19 research? Email us at [email protected] with your order or deposit number so we can prioritize it.

Learn more about our current shipping status and COVID-19 resources.

Please note: Your browser does not support the features used on Addgene's website. You may not be able to create an account or request plasmids through this website until you upgrade your browser. Learn more

Please note: Your browser does not fully support some of the features used on Addgene's website. If you run into any problems registering, depositing, or ordering please contact us at [email protected] Learn more

lentiCRISPR v2 Citations (1006)

Plasmid Article: Improved vectors and genome-wide libraries for CRISPR screening.
Sanjana NE, Shalem O, Zhang F Nat Methods. 2014 Aug;11(8):783-4. doi: 10.1038/nmeth.3047.
PubMed Journal

Articles Citing lentiCRISPR v2

Articles
Defining Akt actions in muscle differentiation. Gardner S, Anguiano M, Rotwein P. Am J Physiol Cell Physiol. 2012 Dec 15;303(12):C1292-300. doi: 10.1152/ajpcell.00259.2012. Epub 2012 Oct 17. PubMed
mTORC1 upregulation via ERK-dependent gene expression change confers intrinsic resistance to MEK inhibitors in oncogenic KRas-mutant cancer cells. Komatsu N, Fujita Y, Matsuda M, Aoki K. Oncogene. 2015 Feb 23. doi: 10.1038/onc.2015.16. PubMed
A Proteomic Strategy Identifies Lysine Methylation of Splicing Factor snRNP70 by the SETMAR Enzyme. Carlson SM, Moore KE, Sankaran SM, Reynoird N, Elias JE, Gozani O. J Biol Chem. 2015 May 8;290(19):12040-7. doi: 10.1074/jbc.M115.641530. Epub 2015 Mar 20. PubMed
LMAN1 (ERGIC-53) is a potential carrier protein for matrix metalloproteinase-9 glycoprotein secretion. Duellman T, Burnett J, Shin A, Yang J. Biochem Biophys Res Commun. 2015 Jul 3. pii: S0006-291X(15)30222-9. doi: 10.1016/j.bbrc.2015.06.164. PubMed
Genome-wide DNA hypomethylation and RNA:DNA hybrid accumulation in Aicardi-Goutieres syndrome. Lim YW, Sanz LA, Xu X, Hartono SR, Chedin F. Elife. 2015 Jul 16;4. doi: 10.7554/eLife.08007. PubMed
CDKN2B Loss Promotes Progression from Benign Melanocytic Nevus to Melanoma. McNeal AS, Liu K, Nakhate V, Natale CA, Duperret EK, Capell BC, Dentchev T, Berger SL, Herlyn M, Seykora JT, Ridky TW. Cancer Discov. 2015 Oct;5(10):1072-85. doi: 10.1158/2159-8290.CD-15-0196. Epub 2015 Jul 16. PubMed
An IkappaB Kinase-Regulated Feedforward Circuit Prolongs Inflammation. Perez JM, Chirieleison SM, Abbott DW. Cell Rep. 2015 Jul 28;12(4):537-44. doi: 10.1016/j.celrep.2015.06.050. Epub 2015 Jul 16. PubMed
Highly Efficient Genome Editing via CRISPR/Cas9 to Create Clock Gene Knockout Cells. Korge S, Grudziecki A, Kramer A. J Biol Rhythms. 2015 Oct;30(5):389-95. doi: 10.1177/0748730415597519. Epub 2015 Aug 4. PubMed
Alternative Wnt Signaling Activates YAP/TAZ. Park HW, Kim YC, Yu B, Moroishi T, Mo JS, Plouffe SW, Meng Z, Lin KC, Yu FX, Alexander CM, Wang CY, Guan KL. Cell. 2015 Aug 13;162(4):780-94. doi: 10.1016/j.cell.2015.07.013. PubMed
Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin. Zhou X, Sun L, Bastos de Oliveira F, Qi X, Brown WJ, Smolka MB, Sun Y, Hu F. J Cell Biol. 2015 Sep 14;210(6):991-1002. doi: 10.1083/jcb.201502029. PubMed
Establishment of leukemia inhibitory factor (LIF)-independent iPS cells with potentiated Oct4. Hirai H, Firpo M, Kikyo N. Stem Cell Res. 2015 Nov;15(3):469-80. doi: 10.1016/j.scr.2015.09.002. Epub 2015 Sep 12. PubMed
ZIC2-dependent OCT4 activation drives self-renewal of human liver cancer stem cells. Zhu P, Wang Y, He L, Huang G, Du Y, Zhang G, Yan X, Xia P, Ye B, Wang S, Hao L, Wu J, Fan Z. J Clin Invest. 2015 Oct 1;125(10):3795-808. doi: 10.1172/JCI81979. Epub 2015 Aug 31. PubMed
Differentiation-Dependent KLF4 Expression Promotes Lytic Epstein-Barr Virus Infection in Epithelial Cells. Nawandar DM, Wang A, Makielski K, Lee D, Ma S, Barlow E, Reusch J, Jiang R, Wille CK, Greenspan D, Greenspan JS, Mertz JE, Hutt-Fletcher L, Johannsen EC, Lambert PF, Kenney SC. PLoS Pathog. 2015 Oct 2;11(10):e1005195. doi: 10.1371/journal.ppat.1005195. eCollection 2015 Oct. PubMed
Growth factor signaling to mTORC1 by amino acid-laden macropinosomes. Yoshida S, Pacitto R, Yao Y, Inoki K, Swanson JA. J Cell Biol. 2015 Oct 12;211(1):159-72. doi: 10.1083/jcb.201504097. Epub 2015 Oct 5. PubMed
Tumor suppressor ASXL1 is essential for the activation of INK4B expression in response to oncogene activity and anti-proliferative signals. Wu X, Bekker-Jensen IH, Christensen J, Rasmussen KD, Sidoli S, Qi Y, Kong Y, Wang X, Cui Y, Xiao Z, Xu G, Williams K, Rappsilber J, Sonderby CK, Winther O, Jensen ON, Helin K. Cell Res. 2015 Nov;25(11):1205-18. doi: 10.1038/cr.2015.121. Epub 2015 Oct 16. PubMed
Genome editing of CXCR4 by CRISPR/cas9 confers cells resistant to HIV-1 infection. Hou P, Chen S, Wang S, Yu X, Chen Y, Jiang M, Zhuang K, Ho W, Hou W, Huang J, Guo D. Sci Rep. 2015 Oct 20;5:15577. doi: 10.1038/srep15577. PubMed
Modulation of Mitochondrial Antiviral Signaling by Human Herpesvirus 8 Interferon Regulatory Factor 1. Hwang KY, Choi YB. J Virol. 2015 Oct 28;90(1):506-20. doi: 10.1128/JVI.01903-15. PubMed
GRHL2 coordinates regeneration of a polarized mucociliary epithelium from basal stem cells. Gao X, Bali AS, Randell SH, Hogan BL. J Cell Biol. 2015 Nov 9;211(3):669-82. doi: 10.1083/jcb.201506014. Epub 2015 Nov 2. PubMed
GCN2 sustains mTORC1 suppression upon amino acid deprivation by inducing Sestrin2. Ye J, Palm W, Peng M, King B, Lindsten T, Li MO, Koumenis C, Thompson CB. Genes Dev. 2015 Nov 15;29(22):2331-6. doi: 10.1101/gad.269324.115. Epub 2015 Nov 5. PubMed
Cargo-selective apical exocytosis in epithelial cells is conducted by Myo5B, Slp4a, Vamp7, and Syntaxin 3. Vogel GF, Klee KM, Janecke AR, Muller T, Hess MW, Huber LA. J Cell Biol. 2015 Nov 9;211(3):587-604. doi: 10.1083/jcb.201506112. PubMed
Activation of Type I and III Interferon Response by Mitochondrial and Peroxisomal MAVS and Inhibition by Hepatitis C Virus. Bender S, Reuter A, Eberle F, Einhorn E, Binder M, Bartenschlager R. PLoS Pathog. 2015 Nov 20;11(11):e1005264. doi: 10.1371/journal.ppat.1005264. eCollection 2015 Nov. PubMed
CRISPR-Cas9 delivery to hard-to-transfect cells via membrane deformation. Han X, Liu Z, Jo MC, Zhang K, Li Y, Zeng Z, Li N, Zu Y, Qin L. Sci Adv. 2015 Aug 14;1(7):e1500454. doi: 10.1126/sciadv.1500454. eCollection 2015 Aug. PubMed
Peptidic degron in EID1 is recognized by an SCF E3 ligase complex containing the orphan F-box protein FBXO21. Zhang C, Li X, Adelmant G, Dobbins J, Geisen C, Oser MG, Wucherpfenning KW, Marto JA, Kaelin WG Jr. Proc Natl Acad Sci U S A. 2015 Dec 15;112(50):15372-7. doi: 10.1073/pnas.1522006112. Epub 2015 Dec 2. PubMed
Characterization of a Novel Human-Specific STING Agonist that Elicits Antiviral Activity Against Emerging Alphaviruses. Sali TM, Pryke KM, Abraham J, Liu A, Archer I, Broeckel R, Staverosky JA, Smith JL, Al-Shammari A, Amsler L, Sheridan K, Nilsen A, Streblow DN, DeFilippis VR. PLoS Pathog. 2015 Dec 8;11(12):e1005324. doi: 10.1371/journal.ppat.1005324. eCollection 2015 Dec. PubMed
LUBAC-Recruited CYLD and A20 Regulate Gene Activation and Cell Death by Exerting Opposing Effects on Linear Ubiquitin in Signaling Complexes. Draber P, Kupka S, Reichert M, Draberova H, Lafont E, de Miguel D, Spilgies L, Surinova S, Taraborrelli L, Hartwig T, Rieser E, Martino L, Rittinger K, Walczak H. Cell Rep. 2015 Dec 15;13(10):2258-72. doi: 10.1016/j.celrep.2015.11.009. Epub 2015 Dec 6. PubMed
Spell Checking Nature: Versatility of CRISPR/Cas9 for Developing Treatments for Inherited Disorders. Wojtal D, Kemaladewi DU, Malam Z, Abdullah S, Wong TW, Hyatt E, Baghestani Z, Pereira S, Stavropoulos J, Mouly V, Mamchaoui K, Muntoni F, Voit T, Gonorazky HD, Dowling JJ, Wilson MD, Mendoza-Londono R, Ivakine EA, Cohn RD. Am J Hum Genet. 2016 Jan 7;98(1):90-101. doi: 10.1016/j.ajhg.2015.11.012. Epub 2015 Dec 10. PubMed
Functional genetic screens for enhancer elements in the human genome using CRISPR-Cas9. Korkmaz G, Lopes R, Ugalde AP, Nevedomskaya E, Han R, Myacheva K, Zwart W, Elkon R, Agami R. Nat Biotechnol. 2016 Feb;34(2):192-8. doi: 10.1038/nbt.3450. Epub 2016 Jan 11. PubMed
Epithelial-to-Mesenchymal Transition of RPE Cells In Vitro Confers Increased beta1,6-N-Glycosylation and Increased Susceptibility to Galectin-3 Binding. Priglinger CS, Obermann J, Szober CM, Merl-Pham J, Ohmayer U, Behler J, Gruhn F, Kreutzer TC, Wertheimer C, Geerlof A, Priglinger SG, Hauck SM. PLoS One. 2016 Jan 13;11(1):e0146887. doi: 10.1371/journal.pone.0146887. eCollection 2016. PubMed
TRIM5alpha degradation via autophagy is not required for retroviral restriction. Imam S, Talley S, Nelson RS, Dharan A, O'Connor C, Hope TJ, Campbell EM. J Virol. 2016 Jan 13. pii: JVI.03033-15. PubMed

Associated Plasmids

Exploiting the CRISPR/Cas9 PAM Constraint for Single-Nucleotide Resolution Interventions. Li Y, Mendiratta S, Ehrhardt K, Kashyap N, White MA, Bleris L. PLoS One. 2016 Jan 20;11(1):e0144970. doi: 10.1371/journal.pone.0144970. eCollection 2016. PubMed
Impaired killing of Candida albicans by granulocytes mobilized for transfusion purposes: a role for granule components. Gazendam RP, van de Geer A, van Hamme JL, Tool AT, van Rees DJ, Aarts CE, van den Biggelaar M, van Alphen F, Verkuijlen P, Meijer AB, Janssen H, Roos D, van den Berg TK, Kuijpers TW. Haematologica. 2016 May;101(5):587-96. doi: 10.3324/haematol.2015.136630. Epub 2016 Jan 22. PubMed
Is BOK required for apoptosis induced by endoplasmic reticulum stress? Fernandez-Marrero Y, Ke F, Echeverry N, Bouillet P, Bachmann D, Strasser A, Kaufmann T. Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):E492-3. doi: 10.1073/pnas.1516347113. Epub 2016 Jan 25. PubMed
NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux. He Y, Zeng MY, Yang D, Motro B, Nunez G. Nature. 2016 Feb 18;530(7590):354-7. doi: 10.1038/nature16959. Epub 2016 Jan 27. PubMed
DeltaNp63 regulates cell proliferation, differentiation, adhesion, and migration in the BL2 subtype of basal-like breast cancer. Orzol P, Nekulova M, Holcakova J, Muller P, Votesek B, Coates PJ. Tumour Biol. 2016 Jan 29. PubMed
Mito-priming as a method to engineer Bcl-2 addiction. Lopez J, Bessou M, Riley JS, Giampazolias E, Todt F, Rochegue T, Oberst A, Green DR, Edlich F, Ichim G, Tait SW. Nat Commun. 2016 Feb 2;7:10538. doi: 10.1038/ncomms10538. PubMed

Associated Plasmids

The Sigma-2 Receptor and Progesterone Receptor Membrane Component 1 are Different Binding Sites Derived From Independent Genes. Chu UB, Mavlyutov TA, Chu ML, Yang H, Schulman A, Mesangeau C, McCurdy CR, Guo LW, Ruoho AE. EBioMedicine. 2015 Oct 19;2(11):1806-13. doi: 10.1016/j.ebiom.2015.10.017. eCollection 2015 Nov. PubMed
MUC1-C drives MYC in multiple myeloma. Tagde A, Rajabi H, Bouillez A, Alam M, Gali R, Bailey S, Tai YT, Hideshima T, Anderson K, Avigan D, Kufe D. Blood. 2016 May 26;127(21):2587-97. doi: 10.1182/blood-2015-07-659151. Epub 2016 Feb 23. PubMed
The retrovirus HTLV-1 inserts an ectopic CTCF-binding site into the human genome. Satou Y, Miyazato P, Ishihara K, Yaguchi H, Melamed A, Miura M, Fukuda A, Nosaka K, Watanabe T, Rowan AG, Nakao M, Bangham CR. Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):3054-9. doi: 10.1073/pnas.1423199113. Epub 2016 Feb 29. PubMed
Screening and identification of proteins interacting with IL-24 by the yeast two-hybrid screen, Co-IP, and FRET assays. Hu H, Wang T, Chen J, Yu F, Liu H, Zuo Z, Yang Z, Fan H. Anticancer Drugs. 2016 Apr;27(4):318-27. doi: 10.1097/CAD.0000000000000343. PubMed
Single Guide RNA Library Design and Construction. Wang T, Lander ES, Sabatini DM. Cold Spring Harb Protoc. 2016 Mar 1;2016(3):pdb.prot090803. doi: 10.1101/pdb.prot090803. PubMed
Global Analysis of Cellular Protein Flux Quantifies the Selectivity of Basal Autophagy. Zhang T, Shen S, Qu J, Ghaemmaghami S. Cell Rep. 2016 Mar 15;14(10):2426-39. doi: 10.1016/j.celrep.2016.02.040. Epub 2016 Mar 3. PubMed
Editing of mouse and human immunoglobulin genes by CRISPR-Cas9 system. Cheong TC, Compagno M, Chiarle R. Nat Commun. 2016 Mar 9;7:10934. doi: 10.1038/ncomms10934. PubMed
Thrombin-Mediated Direct Activation of Proteinase-Activated Receptor-2: Another Target for Thrombin Signaling. Mihara K, Ramachandran R, Saifeddine M, Hansen KK, Renaux B, Polley D, Gibson S, Vanderboor C, Hollenberg MD. Mol Pharmacol. 2016 May;89(5):606-14. doi: 10.1124/mol.115.102723. Epub 2016 Mar 8. PubMed
NK Cells Respond to Haptens by the Activation of Calcium Permeable Plasma Membrane Channels. Grandclement C, Pick H, Vogel H, Held W. PLoS One. 2016 Mar 10;11(3):e0151031. doi: 10.1371/journal.pone.0151031. eCollection 2016. PubMed
The deubiquitinase Usp27x stabilizes the BH3-only protein Bim and enhances apoptosis. Weber A, Heinlein M, Dengjel J, Alber C, Singh PK, Hacker G. EMBO Rep. 2016 May;17(5):724-38. doi: 10.15252/embr.201541392. Epub 2016 Mar 24. PubMed
ROR-gamma drives androgen receptor expression and represents a therapeutic target in castration-resistant prostate cancer. Wang J, Zou JX, Xue X, Cai D, Zhang Y, Duan Z, Xiang Q, Yang JC, Louie MC, Borowsky AD, Gao AC, Evans CP, Lam KS, Xu J, Kung HJ, Evans RM, Xu Y, Chen HW. Nat Med. 2016 May;22(5):488-96. doi: 10.1038/nm.4070. Epub 2016 Mar 28. PubMed
ATRX binds to atypical chromatin domains at the 3' exons of zinc finger genes to preserve H3K9me3 enrichment. Valle-Garcia D, Qadeer ZA, McHugh DS, Ghiraldini FG, Chowdhury AH, Hasson D, Dyer MA, Recillas-Targa F, Bernstein E. Epigenetics. 2016 Jun 2;11(6):398-414. doi: 10.1080/15592294.2016.1169351. Epub 2016 Mar 30. PubMed
A homeobox protein, NKX6.1, up-regulates interleukin-6 expression for cell growth in basal-like breast cancer cells. Li W, Itou J, Tanaka S, Nishimura T, Sato F, Toi M. Exp Cell Res. 2016 May 1;343(2):177-89. doi: 10.1016/j.yexcr.2016.03.023. Epub 2016 Mar 28. PubMed
Activation by SLAM Family Receptors Contributes to NK Cell Mediated "Missing-Self" Recognition. Alari-Pahissa E, Grandclement C, Jeevan-Raj B, Leclercq G, Veillette A, Held W. PLoS One. 2016 Apr 7;11(4):e0153236. doi: 10.1371/journal.pone.0153236. eCollection 2016. PubMed
Genome-wide CRISPR screen reveals novel host factors required for Staphylococcus aureus alpha-hemolysin-mediated toxicity. Virreira Winter S, Zychlinsky A, Bardoel BW. Sci Rep. 2016 Apr 12;6:24242. doi: 10.1038/srep24242. PubMed
Genome-Wide CRISPR-Cas9 Screen Identifies MicroRNAs That Regulate Myeloid Leukemia Cell Growth. Wallace J, Hu R, Mosbruger TL, Dahlem TJ, Stephens WZ, Rao DS, Round JL, O'Connell RM. PLoS One. 2016 Apr 15;11(4):e0153689. doi: 10.1371/journal.pone.0153689. eCollection 2016. PubMed
NOD1 Participates in the Innate Immune Response Triggered by Hepatitis C Virus Polymerase. Vegna S, Gregoire D, Moreau M, Lassus P, Durantel D, Assenat E, Hibner U, Simonin Y. J Virol. 2016 Jun 10;90(13):6022-35. doi: 10.1128/JVI.03230-15. Print 2016 Jul 1. PubMed
DHX9/RHA Binding to the PBS-Segment of the Genomic RNA during HIV-1 Assembly Bolsters Virion Infectivity. Boeras I, Song Z, Moran A, Franklin J, Brown WC, Johnson M, Boris-Lawrie K, Heng X. J Mol Biol. 2016 Jun 5;428(11):2418-29. doi: 10.1016/j.jmb.2016.04.011. Epub 2016 Apr 21. PubMed
CRISPR knockout screening outperforms shRNA and CRISPRi in identifying essential genes. Evers B, Jastrzebski K, Heijmans JP, Grernrum W, Beijersbergen RL, Bernards R. Nat Biotechnol. 2016 Jun;34(6):631-3. doi: 10.1038/nbt.3536. Epub 2016 Apr 25. PubMed
An essential role for Grk2 in Hedgehog signalling downstream of Smoothened. Zhao Z, Lee RT, Pusapati GV, Iyu A, Rohatgi R, Ingham PW. EMBO Rep. 2016 May;17(5):739-52. doi: 10.15252/embr.201541532. Epub 2016 Apr 4. PubMed
Sex steroids regulate skin pigmentation through nonclassical membrane-bound receptors. Natale CA, Duperret EK, Zhang J, Sadeghi R, Dahal A, O'Brien KT, Cookson R, Winkler JD, Ridky TW. Elife. 2016 Apr 26;5. pii: e15104. doi: 10.7554/eLife.15104. PubMed
EVI1 Interferes with Myeloid Maturation via Transcriptional Repression of Cebpa, via Binding to Two Far Downstream Regulatory Elements. Wilson M, Tsakraklides V, Tran M, Xiao YY, Zhang Y, Perkins AS. J Biol Chem. 2016 Jun 24;291(26):13591-607. doi: 10.1074/jbc.M115.708156. Epub 2016 Apr 21. PubMed
The mitochondrial calcium uniporter regulates breast cancer progression via HIF-1alpha. Tosatto A, Sommaggio R, Kummerow C, Bentham RB, Blacker TS, Berecz T, Duchen MR, Rosato A, Bogeski I, Szabadkai G, Rizzuto R, Mammucari C. EMBO Mol Med. 2016 May 2;8(5):569-85. doi: 10.15252/emmm.201606255. PubMed
RBFOX1 and RBFOX2 are dispensable in iPSCs and iPSC-derived neurons and do not contribute to neural-specific paternal UBE3A silencing. Chen PF, Hsiao JS, Sirois CL, Chamberlain SJ. Sci Rep. 2016 May 5;6:25368. doi: 10.1038/srep25368. PubMed
Characterizing the differences between the 2D and 3D measurements of spine in adolescent idiopathic scoliosis. Pasha S, Cahill PJ, Dormans JP, Flynn JM. Eur Spine J. 2016 Oct;25(10):3137-3145. Epub 2016 May 4. PubMed
RISC-mediated control of selected chromatin regulators stabilizes ground state pluripotency of mouse embryonic stem cells. Pandolfini L, Luzi E, Bressan D, Ucciferri N, Bertacchi M, Brandi R, Rocchiccioli S, D'Onofrio M, Cremisi F. Genome Biol. 2016 May 6;17(1):94. doi: 10.1186/s13059-016-0952-x. PubMed
NFAT restricts osteochondroma formation from entheseal progenitors. Ge X, Tsang K, He L, Garcia RA, Ermann J, Mizoguchi F, Zhang M, Zhou B, Zhou B, Aliprantis AO. JCI Insight. 2016 Apr;1(4):e86254. PubMed
Targeted positron emission tomography imaging of CXCR4 expression in patients with acute myeloid leukemia. Herhaus P, Habringer S, Philipp-Abbrederis K, Vag T, Gerngross C, Schottelius M, Slotta-Huspenina J, Steiger K, Altmann T, Weisser T, Steidle S, Schick M, Jacobs L, Slawska J, Mueller-Thomas C, Verbeek M, Subklewe M, Peschel C, Wester HJ, Schwaiger M, Goetze K, Keller U. Haematologica. 2016 May 12. pii: haematol.2016.142976. PubMed
The histone methyltransferase EZH2 as a novel prosurvival factor in clinically aggressive chronic lymphocytic leukemia. Papakonstantinou N, Ntoufa S, Chartomatsidou E, Kotta K, Agathangelidis A, Giassafaki L, Karamanli T, Bele P, Moysiadis T, Baliakas P, Sutton LA, Stavroyianni N, Anagnostopoulos A, Makris AM, Ghia P, Rosenquist R, Stamatopoulos K. Oncotarget. 2016 Jun 14;7(24):35946-35959. doi: 10.18632/oncotarget.9371. PubMed
Discovery of a Small-Molecule BMP Sensitizer for Human Embryonic Stem Cell Differentiation. Feng L, Cook B, Tsai SY, Zhou T, LaFlamme B, Evans T, Chen S. Cell Rep. 2016 May 31;15(9):2063-75. doi: 10.1016/j.celrep.2016.04.066. Epub 2016 May 19. PubMed
Whole organism lineage tracing by combinatorial and cumulative genome editing. McKenna A, Findlay GM, Gagnon JA, Horwitz MS, Schier AF, Shendure J. Science. 2016 May 26. pii: aaf7907. PubMed

Associated Plasmids

Combining single-strand oligodeoxynucleotides and CRISPR/Cas9 to correct gene mutations in Beta-thalassemia-induced Pluripotent Stem Cells. Niu X, He W, Song B, Ou Z, Fan D, Chen Y, Fan Y, Sun X. J Biol Chem. 2016 Jun 10. pii: jbc.M116.719237. PubMed
Autocrine Complement Inhibits IL10-Dependent T-Cell Mediated Antitumor Immunity to Promote Tumor Progression. Wang Y, Sun SN, Liu Q, Yu YY, Guo J, Wang K, Xing BC, Zheng QF, Campa MJ, Patz EF, Li SY, He YW. Cancer Discov. 2016 Jun 13. pii: CD-15-1412. PubMed
Combination of the clustered regularly interspaced short palindromic repeats (CRISPR)-associated 9 technique with the piggybac transposon system for mouse in utero electroporation to study cortical development. Cheng M, Jin X, Mu L, Wang F, Li W, Zhong X, Liu X, Shen W, Liu Y, Zhou Y. J Neurosci Res. 2016 Jun 18. doi: 10.1002/jnr.23776. PubMed
Tyrosine phosphorylation regulates ERbeta ubiquitination, protein turnover, and inhibition of breast cancer. Yuan B, Cheng L, Gupta K, Chiang HC, Gupta HB, Sareddy GR, Wang D, Lathrop K, Elledge R, Wang P, McHardy S, Vadlamudi R, Curiel TJ, Hu Y, Ye Q, Li R. Oncotarget. 2016 Jul 5;7(27):42585-42597. doi: 10.18632/oncotarget.10018. PubMed
Viral FGARAT Homolog ORF75 of Rhesus Monkey Rhadinovirus Effects Proteasomal Degradation of the ND10 Components SP100 and PML. Hahn AS, Grosskopf AK, Jungnickl D, Scholz B, Ensser A. J Virol. 2016 Aug 12;90(17):8013-28. doi: 10.1128/JVI.01181-16. Print 2016 Sep 1. PubMed
Practical Considerations for Using Pooled Lentiviral CRISPR Libraries. McDade JR, Waxmonsky NC, Swanson LE, Fan M. Curr Protoc Mol Biol. 2016 Jul 1;115:31.5.1-31.5.13. doi: 10.1002/cpmb.8. PubMed
Multiple mechanisms disrupt the let-7 microRNA family in neuroblastoma. Powers JT, Tsanov KM, Pearson DS, Roels F, Spina CS, Ebright R, Seligson M, de Soysa Y, Cahan P, Theissen J, Tu HC, Han A, Kurek KC, LaPier GS, Osborne JK, Ross SJ, Cesana M, Collins JJ, Berthold F, Daley GQ. Nature. 2016 Jul 14;535(7611):246-51. doi: 10.1038/nature18632. PubMed
Homologous recombination-dependent repair of telomeric DSBs in proliferating human cells. Mao P, Liu J, Zhang Z, Zhang H, Liu H, Gao S, Rong YS, Zhao Y. Nat Commun. 2016 Jul 11;7:12154. doi: 10.1038/ncomms12154. PubMed
53BP1 and USP28 mediate p53 activation and G1 arrest after centrosome loss or extended mitotic duration. Meitinger F, Anzola JV, Kaulich M, Richardson A, Stender JD, Benner C, Glass CK, Dowdy SF, Desai A, Shiau AK, Oegema K. J Cell Biol. 2016 Jul 18;214(2):155-66. doi: 10.1083/jcb.201604081. PubMed
PARP Inhibitor Activity Correlates with SLFN11 Expression and Demonstrates Synergy with Temozolomide in Small Cell Lung Cancer. Lok BH, Gardner EE, Schneeberger VE, Ni A, Desmeules P, Rekhtman N, de Stanchina E, Teicher BA, Riaz N, Powell SN, Poirier JT, Rudin CM. Clin Cancer Res. 2017 Jan 15;23(2):523-535. doi: 10.1158/1078-0432.CCR-16-1040. Epub 2016 Jul 20. PubMed
Activation of cell-surface proteases promotes necroptosis, inflammation and cell migration. Cai Z, Zhang A, Choksi S, Li W, Li T, Zhang XM, Liu ZG. Cell Res. 2016 Aug;26(8):886-900. doi: 10.1038/cr.2016.87. Epub 2016 Jul 22. PubMed
CD19 CAR immune pressure induces B-precursor acute lymphoblastic leukaemia lineage switch exposing inherent leukaemic plasticity. Jacoby E, Nguyen SM, Fountaine TJ, Welp K, Gryder B, Qin H, Yang Y, Chien CD, Seif AE, Lei H, Song YK, Khan J, Lee DW, Mackall CL, Gardner RA, Jensen MC, Shern JF, Fry TJ. Nat Commun. 2016 Jul 27;7:12320. doi: 10.1038/ncomms12320. PubMed
Prediction and Validation of Transcription Factors Modulating the Expression of Sestrin3 Gene Using an Integrated Computational and Experimental Approach. Srivastava R, Zhang Y, Xiong X, Zhang X, Pan X, Dong XC, Liangpunsakul S, Janga SC. PLoS One. 2016 Jul 28;11(7):e0160228. doi: 10.1371/journal.pone.0160228. eCollection 2016. PubMed
Musashi1 Impacts Radio-Resistance in Glioblastoma by Controlling DNA-Protein Kinase Catalytic Subunit. de Araujo PR, Gorthi A, da Silva AE, Tonapi SS, Vo DT, Burns SC, Qiao M, Uren PJ, Yuan ZM, Bishop AJ, Penalva LO. Am J Pathol. 2016 Sep;186(9):2271-8. doi: 10.1016/j.ajpath.2016.05.020. Epub 2016 Jul 25. PubMed
Parallel reverse genetic screening in mutant human cells using transcriptomics. Gapp BV, Konopka T, Penz T, Dalal V, Burckstummer T, Bock C, Nijman SM. Mol Syst Biol. 2016 Aug 1;12(8):879. doi: 10.15252/msb.20166890. PubMed
Chromatin-Remodeling Complex SWI/SNF Controls Multidrug Resistance by Transcriptionally Regulating the Drug Efflux Pump ABCB1. Dubey R, Lebensohn AM, Bahrami-Nejad Z, Marceau C, Champion M, Gevaert O, Sikic BI, Carette JE, Rohatgi R. Cancer Res. 2016 Oct 1;76(19):5810-5821. Epub 2016 Aug 8. PubMed
A genome-editing strategy to treat beta-hemoglobinopathies that recapitulates a mutation associated with a benign genetic condition. Traxler EA, Yao Y, Wang YD, Woodard KJ, Kurita R, Nakamura Y, Hughes JR, Hardison RC, Blobel GA, Li C, Weiss MJ. Nat Med. 2016 Sep;22(9):987-90. doi: 10.1038/nm.4170. Epub 2016 Aug 15. PubMed
Modulation of long noncoding RNAs by risk SNPs underlying genetic predispositions to prostate cancer. Guo H, Ahmed M, Zhang F, Yao CQ, Li S, Liang Y, Hua J, Soares F, Sun Y, Langstein J, Li Y, Poon C, Bailey SD, Desai K, Fei T, Li Q, Sendorek DH, Fraser M, Prensner JR, Pugh TJ, Pomerantz M, Bristow RG, Lupien M, Feng FY, Boutros PC, Freedman ML, Walsh MJ, He HH. Nat Genet. 2016 Oct;48(10):1142-50. doi: 10.1038/ng.3637. Epub 2016 Aug 15. PubMed
Comprehensive Protocols for CRISPR/Cas9-based Gene Editing in Human Pluripotent Stem Cells. Santos DP, Kiskinis E, Eggan K, Merkle FT. Curr Protoc Stem Cell Biol. 2016 Aug 17;38:5B.6.1-5B.6.60. doi: 10.1002/cpsc.15. PubMed
The Breast Cancer Tumor Suppressor TRIM29 Is Expressed via ATM-dependent Signaling in Response to Hypoxia. Dukel M, Streitfeld WS, Tang TC, Backman LR, Ai L, May WS, Brown KD. J Biol Chem. 2016 Oct 7;291(41):21541-21552. Epub 2016 Aug 17. PubMed
Cell-Intrinsic Determinants of Ibrutinib-Induced Apoptosis in Chronic Lymphocytic Leukemia. Amin NA, Balasubramanian S, Saiya-Cork K, Shedden K, Hu N, Malek SN. Clin Cancer Res. 2016 Aug 17. doi: 10.1158/1078-0432.CCR-15-2921. PubMed
Type I gamma Phosphatidylinositol Phosphate 5-Kinase i5 Controls the Ubiquitination and Degradation of the Tumor Suppressor Mitogen-inducible Gene 6. Sun M, Cai J, Anderson RA, Sun Y. J Biol Chem. 2016 Oct 7;291(41):21461-21473. doi: 10.1074/jbc.M116.736041. Epub 2016 Aug 24. PubMed
Affinity Purification of the Hepatitis C Virus Replicase Identifies Valosin-Containing Protein, a Member of the ATPases Associated with Diverse Cellular Activities Family, as an Active Virus Replication Modulator. Yi Z, Fang C, Zou J, Xu J, Song W, Du X, Pan T, Lu H, Yuan Z. J Virol. 2016 Oct 14;90(21):9953-9966. Print 2016 Nov 1. PubMed
Pharmacological eEF2K activation promotes cell death and inhibits cancer progression. De Gassart A, Demaria O, Panes R, Zaffalon L, Ryazanov AG, Gilliet M, Martinon F. EMBO Rep. 2016 Oct;17(10):1471-1484. Epub 2016 Aug 29. PubMed
An Aryl Hydrocarbon Receptor-Mediated Amplification Loop That Enforces Cell Migration in ER-/PR-/Her2- Human Breast Cancer Cells. Novikov O, Wang Z, Stanford EA, Parks AJ, Ramirez-Cardenas A, Landesman E, Laklouk I, Sarita-Reyes C, Gusenleitner D, Li A, Monti S, Manteiga S, Lee K, Sherr DH. Mol Pharmacol. 2016 Nov;90(5):674-688. doi: 10.1124/mol.116.105361. Epub 2016 Aug 29. PubMed
A method to convert mRNA into a gRNA library for CRISPR/Cas9 editing of any organism. Arakawa H. Sci Adv. 2016 Aug 24;2(8):e1600699. doi: 10.1126/sciadv.1600699. eCollection 2016 Aug. PubMed
A PGC1alpha-mediated transcriptional axis suppresses melanoma metastasis. Luo C, Lim JH, Lee Y, Granter SR, Thomas A, Vazquez F, Widlund HR, Puigserver P. Nature. 2016 Sep 15;537(7620):422-426. doi: 10.1038/nature19347. Epub 2016 Aug 31. PubMed
Aurora A kinase activates YAP signaling in triple-negative breast cancer. Chang SS, Yamaguchi H, Xia W, Lim SO, Khotskaya Y, Wu Y, Chang WC, Liu Q, Hung MC. Oncogene. 2016 Sep 5. doi: 10.1038/onc.2016.292. PubMed
TGF-beta-induced stromal CYR61 promotes resistance to gemcitabine in pancreatic ductal adenocarcinoma through downregulation of the nucleoside transporters hENT1 and hCNT3. Hesler RA, Huang JJ, Starr MD, Treboschi VM, Bernanke AG, Nixon AB, McCall SJ, White RR, Blobe GC. Carcinogenesis. 2016 Sep 7. pii: bgw093. PubMed
Identification of oncogenic driver mutations by genome-wide CRISPR-Cas9 dropout screening. Kiessling MK, Schuierer S, Stertz S, Beibel M, Bergling S, Knehr J, Carbone W, de Valliere C, Tchinda J, Bouwmeester T, Seuwen K, Rogler G, Roma G. BMC Genomics. 2016 Sep 9;17(1):723. doi: 10.1186/s12864-016-3042-2. PubMed
NFIB overexpression cooperates with Rb/p53 deletion to promote small cell lung cancer. Wu N, Jia D, Ibrahim AH, Bachurski CJ, Gronostajski RM, MacPherson D. Oncotarget. 2016 Sep 6;7(36):57514-57524. doi: 10.18632/oncotarget.11583. PubMed
Identification of Interferon-Stimulated Genes with Antiretroviral Activity. Kane M, Zang TM, Rihn SJ, Zhang F, Kueck T, Alim M, Schoggins J, Rice CM, Wilson SJ, Bieniasz PD. Cell Host Microbe. 2016 Sep 14;20(3):392-405. doi: 10.1016/j.chom.2016.08.005. PubMed
Permanent inactivation of Huntington's disease mutation by personalized allele-specific CRISPR/Cas9. Shin JW, Kim KH, Chao MJ, Atwal RS, Gillis T, MacDonald ME, Gusella JF, Lee JM. Hum Mol Genet. 2016 Sep 15. pii: ddw286. PubMed
Nutritional Stress Induced by Tryptophan-Degrading Enzymes Results in ATF4-Dependent Reprogramming of the Amino Acid Transporter Profile in Tumor Cells. Timosenko E, Ghadbane H, Silk JD, Shepherd D, Gileadi U, Howson LJ, Laynes R, Zhao Q, Strausberg RL, Olsen LR, Taylor S, Buffa FM, Boyd R, Cerundolo V. Cancer Res. 2016 Nov 1;76(21):6193-6204. Epub 2016 Sep 20. PubMed
Challenges of CRISPR/Cas9 applications for long non-coding RNA genes. Goyal A, Myacheva K, Gross M, Klingenberg M, Duran Arque B, Diederichs S. Nucleic Acids Res. 2016 Sep 30. pii: gkw883. PubMed
Systematic and functional characterization of novel androgen receptor variants arising from alternative splicing in the ligand-binding domain. Uo T, Dvinge H, Sprenger CC, Bradley RK, Nelson PS, Plymate SR. Oncogene. 2016 Oct 3. doi: 10.1038/onc.2016.313. PubMed
Regulation of the CUL3 Ubiquitin Ligase by a Calcium-Dependent Co-adaptor. McGourty CA, Akopian D, Walsh C, Gorur A, Werner A, Schekman R, Bautista D, Rape M. Cell. 2016 Oct 6;167(2):525-538.e14. doi: 10.1016/j.cell.2016.09.026. PubMed
Targeting ABCB1-mediated tumor multidrug resistance by CRISPR/Cas9-based genome editing. Yang Y, Qiu JG, Li Y, Di JM, Zhang WJ, Jiang QW, Zheng DW, Chen Y, Wei MN, Huang JR, Wang K, Shi Z. Am J Transl Res. 2016 Sep 15;8(9):3986-3994. eCollection 2016. PubMed
TAX1BP1 Restrains Virus-Induced Apoptosis by Facilitating Itch-Mediated Degradation of the Mitochondrial Adaptor MAVS. Choi YB, Shembade N, Parvatiyar K, Balachandran S, Harhaj EW. Mol Cell Biol. 2016 Dec 19;37(1). pii: e00422-16. Print 2017 Jan 1. PubMed
L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity. Geiger R, Rieckmann JC, Wolf T, Basso C, Feng Y, Fuhrer T, Kogadeeva M, Picotti P, Meissner F, Mann M, Zamboni N, Sallusto F, Lanzavecchia A. Cell. 2016 Oct 20;167(3):829-842.e13. doi: 10.1016/j.cell.2016.09.031. Epub 2016 Oct 13. PubMed
Translocon component Sec62 acts in endoplasmic reticulum turnover during stress recovery. Fumagalli F, Noack J, Bergmann TJ, Cebollero E, Pisoni GB, Fasana E, Fregno I, Galli C, Loi M, Solda T, D'Antuono R, Raimondi A, Jung M, Melnyk A, Schorr S, Schreiber A, Simonelli L, Varani L, Wilson-Zbinden C, Zerbe O, Hofmann K, Peter M, Quadroni M, Zimmermann R, Molinari M. Nat Cell Biol. 2016 Nov;18(11):1173-1184. doi: 10.1038/ncb3423. Epub 2016 Oct 17. PubMed
Genetically Engineered Macrophages: A Potential Platform for Cancer Immunotherapy. Moyes KW, Lieberman NA, Kreuser SA, Chinn H, Winter C, Deutsch G, Hoglund V, Watson R, Crane CA. Hum Gene Ther. 2016 Oct 18. PubMed
Genomic Disruption of VEGF-A Expression in Human Retinal Pigment Epithelial Cells Using CRISPR-Cas9 Endonuclease. Yiu G, Tieu E, Nguyen AT, Wong B, Smit-McBride Z. Invest Ophthalmol Vis Sci. 2016 Oct 1;57(13):5490-5497. doi: 10.1167/iovs.16-20296. PubMed

Associated Plasmids

The LIN28B/let-7 axis is a novel therapeutic pathway in multiple myeloma. Manier S, Powers JT, Sacco A, Glavey SV, Huynh D, Reagan MR, Salem KZ, Moschetta M, Shi J, Mishima Y, Roche-Lestienne C, Leleu X, Roccaro AM, Daley GQ, Ghobrial IM. Leukemia. 2016 Nov 11. doi: 10.1038/leu.2016.296. PubMed
Loss of CYLD expression unleashes Wnt signaling in multiple myeloma and is associated with aggressive disease. van Andel H, Kocemba KA, de Haan-Kramer A, Mellink CH, Piwowar M, Broijl A, van Duin M, Sonneveld P, Maurice MM, Kersten MJ, Spaargaren M, Pals ST. Oncogene. 2016 Oct 24. doi: 10.1038/onc.2016.368. PubMed
The Orai1 Store-operated Calcium Channel Functions as a Hexamer. Cai X, Zhou Y, Nwokonko RM, Loktionova NA, Wang X, Xin P, Trebak M, Wang Y, Gill DL. J Biol Chem. 2016 Dec 9;291(50):25764-25775. Epub 2016 Oct 25. PubMed
TIM-1 Promotes Hepatitis C Virus Cell Attachment and Infection. Wang J, Qiao L, Hou Z, Luo G. J Virol. 2017 Jan 3;91(2). pii: e01583-16. doi: 10.1128/JVI.01583-16. Print 2017 Jan 15. PubMed
--LUBAC deficiency perturbs TLR3 signaling to cause immunodeficiency and autoinflammation. Zinngrebe J, Rieser E, Taraborrelli L, Peltzer N, Hartwig T, Ren H, Kovacs I, Endres C, Draber P, Darding M, von Karstedt S, Lemke J, Dome B, Bergmann M, Ferguson BJ, Walczak H. J Exp Med. 2016 Nov 14;213(12):2671-2689. Epub 2016 Oct 24. PubMed
PAX6 regulates human corneal epithelium cell identity. Kitazawa K, Hikichi T, Nakamura T, Sotozono C, Kinoshita S, Masui S. Exp Eye Res. 2016 Nov 3;154:30-38. doi: 10.1016/j.exer.2016.11.005. PubMed
PROTOCADHERIN 7 Acts through SET and PP2A to Potentiate MAPK Signaling by EGFR and KRAS during Lung Tumorigenesis. Zhou X, Updegraff BL, Guo Y, Peyton M, Girard L, Larsen JE, Xie XJ, Zhou Y, Hwang TH, Xie Y, Rodriguez-Canales J, Villalobos P, Behrens C, Wistuba II, Minna JD, O'Donnell KA. Cancer Res. 2017 Jan 1;77(1):187-197. doi: 10.1158/0008-5472.CAN-16-1267-T. Epub 2016 Nov 7. PubMed

Associated Plasmids

Cytochrome P450 enzymes but not NADPH oxidases are the source of the NADPH-dependent lucigenin chemiluminescence in membrane assays. Rezende F, Prior KK, Lowe O, Wittig I, Strecker V, Moll F, Helfinger V, Schnutgen F, Kurrle N, Wempe F, Walter M, Zukunft S, Luck B, Fleming I, Weissmann N, Brandes RP, Schroder K. Free Radic Biol Med. 2017 Jan;102:57-66. doi: 10.1016/j.freeradbiomed.2016.11.019. Epub 2016 Nov 15. PubMed
A Functional Variant Associated with Atrial Fibrillation Regulates PITX2c Expression through TFAP2a. Ye J, Tucker NR, Weng LC, Clauss S, Lubitz SA, Ellinor PT. Am J Hum Genet. 2016 Dec 1;99(6):1281-1291. doi: 10.1016/j.ajhg.2016.10.001. Epub 2016 Nov 17. PubMed
Alternative splicing of EZH2 pre-mRNA by SF3B3 contributes to the tumorigenic potential of renal cancer. Chen K, Xiao H, Zeng J, Yu G, Zhou H, Huang C, Yao W, Xiao W, Hu J, Guan W, Wu L, Huang J, Huang Q, Xu H, Ye Z. Clin Cancer Res. 2016 Nov 22. pii: clincanres.2020.2016. PubMed
Sulforaphane is a Nrf2-independent inhibitor of mitochondrial fission. O'Mealey GB, Berry WL, Plafker SM. Redox Biol. 2016 Nov 21;11:103-110. doi: 10.1016/j.redox.2016.11.007. PubMed
The tumor suppressor FLCN mediates an alternate mTOR pathway to regulate browning of adipose tissue. Wada S, Neinast M, Jang C, Ibrahim YH, Lee G, Babu A, Li J, Hoshino A, Rowe GC, Rhee J, Martina JA, Puertollano R, Blenis J, Morley M, Baur JA, Seale P, Arany Z. Genes Dev. 2016 Nov 15;30(22):2551-2564. Epub 2016 Dec 2. PubMed
Genetic modification of ER-Hoxb8 osteoclast precursors using CRISPR/Cas9 as a novel way to allow studies on osteoclast biology. Di Ceglie I, van den Akker GG, Ascone G, Ten Harkel B, Hacker H, van de Loo FA, Koenders MI, van der Kraan PM, de Vries TJ, Vogl T, Roth J, van Lent PL. J Leukoc Biol. 2016 Dec 5. pii: jlb.1AB0416-180RR. PubMed
STAT1 is essential for the inhibition of hepatitis C virus replication by interferon-lambda but not by interferon-alpha. Yamauchi S, Takeuchi K, Chihara K, Honjoh C, Kato Y, Yoshiki H, Hotta H, Sada K. Sci Rep. 2016 Dec 8;6:38336. doi: 10.1038/srep38336. PubMed
Viral DNA Sensors IFI16 and Cyclic GMP-AMP Synthase Possess Distinct Functions in Regulating Viral Gene Expression, Immune Defenses, and Apoptotic Responses during Herpesvirus Infection. Diner BA, Lum KK, Toettcher JE, Cristea IM. MBio. 2016 Nov 15;7(6). pii: e01553-16. doi: 10.1128/mBio.01553-16. PubMed
Genome-Wide CRISPR Screen Identifies Regulators of Mitogen-Activated Protein Kinase as Suppressors of Liver Tumors in Mice. Song CQ, Li Y, Mou H, Moore J, Park A, Pomyen Y, Hough S, Kennedy Z, Fischer A, Yin H, Anderson DG, Conte D Jr, Zender L, Wang XW, Thorgeirsson S, Weng Z, Xue W. Gastroenterology. 2017 Apr;152(5):1161-1173.e1. doi: 10.1053/j.gastro.2016.12.002. Epub 2016 Dec 10. PubMed

Associated Plasmids

Targeted genome editing in a quail cell line using a customized CRISPR/Cas9 system. Ahn J, Lee J, Park JY, Oh KB, Hwang S, Lee CW, Lee K. Poult Sci. 2016 Dec 13. pii: pew435. PubMed
Efficient and versatile CRISPR engineering of human neurons in culture to model neurological disorders. Shah RR, Cholewa-Waclaw J, Davies FC, Paton KM, Chaligne R, Heard E, Abbott CM, Bird AP. Wellcome Open Res. 2016 Nov 15;1:13. PubMed
Cell-Based Screen Identifies Human Interferon-Stimulated Regulators of Listeria monocytogenes Infection. Perelman SS, Abrams ME, Eitson JL, Chen D, Jimenez A, Mettlen M, Schoggins JW, Alto NM. PLoS Pathog. 2016 Dec 21;12(12):e1006102. doi: 10.1371/journal.ppat.1006102. eCollection 2016 Dec. PubMed
COPI-TRAPPII activates Rab18 and regulates its lipid droplet association. Li C, Luo X, Zhao S, Siu GK, Liang Y, Chan HC, Satoh A, Yu SS. EMBO J. 2016 Dec 21. pii: e201694866. doi: 10.15252/embj.201694866. PubMed
Argonaute proteins regulate HIV-1 multiply spliced RNA and viral production in a Dicer independent manner. Eckenfelder A, Segeral E, Pinzon N, Ulveling D, Amadori C, Charpentier M, Nidelet S, Concordet JP, Zagury JF, Paillart JC, Berlioz-Torrent C, Seitz H, Emiliani S, Gallois-Montbrun S. Nucleic Acids Res. 2016 Dec 20. pii: gkw1289. doi: 10.1093/nar/gkw1289. PubMed
Epigenetic and Transcriptional Regulation of IRAK-M Expression in Macrophages. Lyroni K, Patsalos A, Daskalaki MG, Doxaki C, Soennichsen B, Helms M, Liapis I, Zacharioudaki V, Kampranis SC, Tsatsanis C. J Immunol. 2016 Dec 23. pii: 1600009. doi: 10.4049/jimmunol.1600009. PubMed
Protein disulfide isomerase externalization in endothelial cells follows classical and unconventional routes. Araujo TL, Zeidler JD, Oliveira PV, Dias MH, Armelin HA, Laurindo FR. Free Radic Biol Med. 2016 Dec 27;103:199-208. doi: 10.1016/j.freeradbiomed.2016.12.021. PubMed
Cytosolic Fc receptor TRIM21 inhibits seeded tau aggregation. McEwan WA, Falcon B, Vaysburd M, Clift D, Oblak AL, Ghetti B, Goedert M, James LC. Proc Natl Acad Sci U S A. 2017 Jan 17;114(3):574-579. doi: 10.1073/pnas.1607215114. Epub 2017 Jan 3. PubMed
Functional Study of the Vitamin K Cycle Enzymes in Live Cells. Tie JK, Stafford DW. Methods Enzymol. 2017;584:349-394. doi: 10.1016/bs.mie.2016.10.015. Epub 2016 Nov 22. PubMed
Oxidized nucleotide insertion by pol beta confounds ligation during base excision repair. Caglayan M, Horton JK, Dai DP, Stefanick DF, Wilson SH. Nat Commun. 2017 Jan 9;8:14045. doi: 10.1038/ncomms14045. PubMed
Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies. Herold N, Rudd SG, Ljungblad L, Sanjiv K, Myrberg IH, Paulin CB, Heshmati Y, Hagenkort A, Kutzner J, Page BD, Calderon-Montano JM, Loseva O, Jemth AS, Bulli L, Axelsson H, Tesi B, Valerie NC, Hoglund A, Bladh J, Wiita E, Sundin M, Uhlin M, Rassidakis G, Heyman M, Tamm KP, Warpman-Berglund U, Walfridsson J, Lehmann S, Grander D, Lundback T, Kogner P, Henter JI, Helleday T, Schaller T. Nat Med. 2017 Jan 9. doi: 10.1038/nm.4265. PubMed
FGF19/FGFR4 signaling contributes to the resistance of hepatocellular carcinoma to sorafenib. Gao L, Wang X, Tang Y, Huang S, Hu CA, Teng Y. J Exp Clin Cancer Res. 2017 Jan 9;36(1):8. doi: 10.1186/s13046-016-0478-9. PubMed
Translation from unconventional 5' start sites drives tumour initiation. Sendoel A, Dunn JG, Rodriguez EH, Naik S, Gomez NC, Hurwitz B, Levorse J, Dill BD, Schramek D, Molina H, Weissman JS, Fuchs E. Nature. 2017 Jan 26;541(7638):494-499. doi: 10.1038/nature21036. Epub 2017 Jan 11. PubMed
Inhibition of 4EBP phosphorylation mediates the cytotoxic effect of mechanistic target of rapamycin kinase inhibitors in aggressive B-cell lymphomas. Bi C, Zhang X, Lu T, Zhang X, Wang X, Meng B, Zhang H, Wang P, Vose JM, Chan WC, McKeithan TW, Fu K. Haematologica. 2017 Apr;102(4):755-764. doi: 10.3324/haematol.2016.159160. Epub 2017 Jan 19. PubMed
ApoE2, ApoE3, and ApoE4 Differentially Stimulate APP Transcription and Abeta Secretion. Huang YA, Zhou B, Wernig M, Sudhof TC. Cell. 2017 Jan 26;168(3):427-441.e21. doi: 10.1016/j.cell.2016.12.044. Epub 2017 Jan 19. PubMed
An Argonaute phosphorylation cycle promotes microRNA-mediated silencing. Golden RJ, Chen B, Li T, Braun J, Manjunath H, Chen X, Wu J, Schmid V, Chang TC, Kopp F, Ramirez-Martinez A, Tagliabracci VS, Chen ZJ, Xie Y, Mendell JT. Nature. 2017 Feb 9;542(7640):197-202. doi: 10.1038/nature21025. Epub 2017 Jan 23. PubMed

Associated Plasmids

Creation of Novel Protein Variants with CRISPR/Cas9-Mediated Mutagenesis: Turning a Screening By-Product into a Discovery Tool. Donovan KF, Hegde M, Sullender M, Vaimberg EW, Johannessen CM, Root DE, Doench JG. PLoS One. 2017 Jan 24;12(1):e0170445. doi: 10.1371/journal.pone.0170445. eCollection 2017. PubMed
The PIDDosome activates p53 in response to supernumerary centrosomes. Fava LL, Schuler F, Sladky V, Haschka MD, Soratroi C, Eiterer L, Demetz E, Weiss G, Geley S, Nigg EA, Villunger A. Genes Dev. 2017 Jan 1;31(1):34-45. doi: 10.1101/gad.289728.116. PubMed
YAP-IL-6ST autoregulatory loop activated on APC loss controls colonic tumorigenesis. Taniguchi K, Moroishi T, de Jong PR, Krawczyk M, Grebbin BM, Luo H, Xu RH, Golob-Schwarzl N, Schweiger C, Wang K, Di Caro G, Feng Y, Fearon ER, Raz E, Kenner L, Farin HF, Guan KL, Haybaeck J, Datz C, Zhang K, Karin M. Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1643-1648. doi: 10.1073/pnas.1620290114. Epub 2017 Jan 27. PubMed
Mutations in EXTL3 Cause Neuro-immuno-skeletal Dysplasia Syndrome. Oud MM, Tuijnenburg P, Hempel M, van Vlies N, Ren Z, Ferdinandusse S, Jansen MH, Santer R, Johannsen J, Bacchelli C, Alders M, Li R, Davies R, Dupuis L, Cale CM, Wanders RJA, Pals ST, Ocaka L, James C, Muller I, Lehmberg K, Strom T, Engels H, Williams HJ, Beales P, Roepman R, Dias P, Brunner HG, Cobben JM, Hall C, Hartley T, Le Quesne Stabej P, Mendoza-Londono R, Davies EG, de Sousa SB, Lessel D, Arts HH, Kuijpers TW. Am J Hum Genet. 2017 Feb 2;100(2):281-296. doi: 10.1016/j.ajhg.2017.01.013. Epub 2017 Jan 26. PubMed
Inhibition of CDK8 mediator kinase suppresses estrogen dependent transcription and the growth of estrogen receptor positive breast cancer. McDermott MS, Chumanevich AA, Lim CU, Liang J, Chen M, Altilia S, Oliver D, Rae JM, Shtutman M, Kiaris H, Gyorffy B, Roninson IB, Broude EV. Oncotarget. 2017 Feb 21;8(8):12558-12575. doi: 10.18632/oncotarget.14894. PubMed
microRNA-210-3p depletion by CRISPR/Cas9 promoted tumorigenesis through revival of TWIST1 in renal cell carcinoma. Yoshino H, Yonemori M, Miyamoto K, Tatarano S, Kofuji S, Nohata N, Nakagawa M, Enokida H. Oncotarget. 2017 Mar 28;8(13):20881-20894. doi: 10.18632/oncotarget.14930. PubMed
Genome Editing Reveals Glioblastoma Addiction to MicroRNA-10b. El Fatimy R, Subramanian S, Uhlmann EJ, Krichevsky AM. Mol Ther. 2017 Feb 1;25(2):368-378. doi: 10.1016/j.ymthe.2016.11.004. PubMed
Erythroid specific activator GATA-1-dependent interactions between CTCF sites around the beta-globin locus. Kang Y, Kim YW, Kang J, Yun WJ, Kim A. Biochim Biophys Acta. 2017 Apr;1860(4):416-426. doi: 10.1016/j.bbagrm.2017.01.013. Epub 2017 Feb 1. PubMed
A genetic interaction analysis identifies cancer drivers that modify EGFR dependency. Liao S, Davoli T, Leng Y, Li MZ, Xu Q, Elledge SJ. Genes Dev. 2017 Jan 15;31(2):184-196. doi: 10.1101/gad.291948.116. Epub 2017 Feb 6. PubMed
AXL-dependent infection of human fetal endothelial cells distinguishes Zika virus from other pathogenic flaviviruses. Richard AS, Shim BS, Kwon YC, Zhang R, Otsuka Y, Schmitt K, Berri F, Diamond MS, Choe H. Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):2024-2029. doi: 10.1073/pnas.1620558114. Epub 2017 Feb 6. PubMed
Challenges of CRISPR/Cas9 applications for long non-coding RNA genes. Goyal A, Myacheva K, Gross M, Klingenberg M, Duran Arque B, Diederichs S. Nucleic Acids Res. 2017 Feb 17;45(3):e12. doi: 10.1093/nar/gkw883. PubMed
Cytosolic DNA Promotes Signal Transducer and Activator of Transcription 3 (STAT3) Phosphorylation by TANK-binding Kinase 1 (TBK1) to Restrain STAT3 Activity. Hsia HC, Hutti JE, Baldwin AS. J Biol Chem. 2017 Mar 31;292(13):5405-5417. doi: 10.1074/jbc.M116.771964. Epub 2017 Feb 10. PubMed
The nuclear transport receptor Importin-11 is a tumor suppressor that maintains PTEN protein. Chen M, Nowak DG, Narula N, Robinson B, Watrud K, Ambrico A, Herzka TM, Zeeman ME, Minderer M, Zheng W, Ebbesen SH, Plafker KS, Stahlhut C, Wang VM, Wills L, Nasar A, Castillo-Martin M, Cordon-Cardo C, Wilkinson JE, Powers S, Sordella R, Altorki NK, Mittal V, Stiles BM, Plafker SM, Trotman LC. J Cell Biol. 2017 Mar 6;216(3):641-656. doi: 10.1083/jcb.201604025. Epub 2017 Feb 13. PubMed
Phosphatidylinositol 3-kinase delta blockade increases genomic instability in B cells. Compagno M, Wang Q, Pighi C, Cheong TC, Meng FL, Poggio T, Yeap LS, Karaca E, Blasco RB, Langellotto F, Ambrogio C, Voena C, Wiestner A, Kasar SN, Brown JR, Sun J, Wu CJ, Gostissa M, Alt FW, Chiarle R. Nature. 2017 Feb 23;542(7642):489-493. doi: 10.1038/nature21406. Epub 2017 Feb 15. PubMed
SZT2 dictates GATOR control of mTORC1 signalling. Peng M, Yin N, Li MO. Nature. 2017 Mar 16;543(7645):433-437. doi: 10.1038/nature21378. Epub 2017 Feb 15. PubMed
Expression level is a key determinant of E2F1-mediated cell fate. Shats I, Deng M, Davidovich A, Zhang C, Kwon JS, Manandhar D, Gordan R, Yao G, You L. Cell Death Differ. 2017 Apr;24(4):626-637. doi: 10.1038/cdd.2017.12. Epub 2017 Feb 17. PubMed
OTX2 Activity at Distal Regulatory Elements Shapes the Chromatin Landscape of Group 3 Medulloblastoma. Boulay G, Awad ME, Riggi N, Archer TC, Iyer S, Boonseng WE, Rossetti NE, Naigles B, Rengarajan S, Volorio A, Kim JC, Mesirov JP, Tamayo P, Pomeroy SL, Aryee MJ, Rivera MN. Cancer Discov. 2017 Mar;7(3):288-301. doi: 10.1158/2159-8290.CD-16-0844. Epub 2017 Feb 17. PubMed
Asparaginyl endopeptidase improves the resistance of microtubule-targeting drugs in gastric cancer through IQGAP1 modulating the EGFR/JNK/ERK signaling pathway. Cui Y, Li Q, Li H, Wang Y, Wang H, Chen W, Zhang S, Cao J, Liu T. Onco Targets Ther. 2017 Feb 3;10:627-643. doi: 10.2147/OTT.S125579. eCollection 2017. PubMed
Critical threshold levels of DNA methyltransferase 1 are required to maintain DNA methylation across the genome in human cancer cells. Cai Y, Tsai HC, Yen RC, Zhang YW, Kong X, Wang W, Xia L, Baylin SB. Genome Res. 2017 Apr;27(4):533-544. doi: 10.1101/gr.208108.116. Epub 2017 Feb 23. PubMed
Application of CRISPR/Cas9 to Autophagy Research. O'Prey J, Sakamaki J, Baudot AD, New M, Van Acker T, Tooze SA, Long JS, Ryan KM. Methods Enzymol. 2017;588:79-108. doi: 10.1016/bs.mie.2016.09.076. Epub 2016 Dec 1. PubMed
Mammalian TRAPPIII Complex positively modulates the recruitment of Sec13/31 onto COPII vesicles. Zhao S, Li CM, Luo XM, Siu GK, Gan WJ, Zhang L, Wu WK, Chan HC, Yu S. Sci Rep. 2017 Feb 27;7:43207. doi: 10.1038/srep43207. PubMed
Editing VEGFR2 Blocks VEGF-Induced Activation of Akt and Tube Formation. Huang X, Zhou G, Wu W, Ma G, D'Amore PA, Mukai S, Lei H. Invest Ophthalmol Vis Sci. 2017 Feb 1;58(2):1228-1236. doi: 10.1167/iovs.16-20537. PubMed
Multiple Histone Lysine Methyltransferases Are Required for the Establishment and Maintenance of HIV-1 Latency. Nguyen K, Das B, Dobrowolski C, Karn J. MBio. 2017 Feb 28;8(1). pii: mBio.00133-17. doi: 10.1128/mBio.00133-17. PubMed
Opposing effects of Nrf2 and Nrf2-activating compounds on the NLRP3 inflammasome independent of Nrf2-mediated gene expression. Garstkiewicz M, Strittmatter GE, Grossi S, Sand J, Fenini G, Werner S, French LE, Beer HD. Eur J Immunol. 2017 May;47(5):806-817. doi: 10.1002/eji.201646665. Epub 2017 Apr 10. PubMed
Pseudohypoxia induced by miR-126 deactivation promotes migration and therapeutic resistance in renal cell carcinoma. Liu W, Chen H, Wong N, Haynes W, Baker CM, Wang X. Cancer Lett. 2017 May 28;394:65-75. doi: 10.1016/j.canlet.2017.02.025. Epub 2017 Feb 28. PubMed
Integrin-beta4 identifies cancer stem cell-enriched populations of partially mesenchymal carcinoma cells. Bierie B, Pierce SE, Kroeger C, Stover DG, Pattabiraman DR, Thiru P, Liu Donaher J, Reinhardt F, Chaffer CL, Keckesova Z, Weinberg RA. Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):E2337-E2346. doi: 10.1073/pnas.1618298114. Epub 2017 Mar 7. PubMed
The Novel Toll-Like Receptor 2 Agonist SUP3 Enhances Antigen Presentation and T Cell Activation by Dendritic Cells. Guo X, Wu N, Shang Y, Liu X, Wu T, Zhou Y, Liu X, Huang J, Liao X, Wu L. Front Immunol. 2017 Feb 21;8:158. doi: 10.3389/fimmu.2017.00158. eCollection 2017. PubMed
Reconstituting development of pancreatic intraepithelial neoplasia from primary human pancreas duct cells. Lee J, Snyder ER, Liu Y, Gu X, Wang J, Flowers BM, Kim YJ, Park S, Szot GL, Hruban RH, Longacre TA, Kim SK. Nat Commun. 2017 Mar 8;8:14686. doi: 10.1038/ncomms14686. PubMed
DUX4-induced dsRNA and MYC mRNA stabilization activate apoptotic pathways in human cell models of facioscapulohumeral dystrophy. Shadle SC, Zhong JW, Campbell AE, Conerly ML, Jagannathan S, Wong CJ, Morello TD, van der Maarel SM, Tapscott SJ. PLoS Genet. 2017 Mar 8;13(3):e1006658. doi: 10.1371/journal.pgen.1006658. eCollection 2017 Mar. PubMed

Associated Plasmids

The vacuolar-ATPase complex and assembly factors, TMEM199 and CCDC115, control HIF1alpha prolyl hydroxylation by regulating cellular iron levels. Miles AL, Burr SP, Grice GL, Nathan JA. Elife. 2017 Mar 15;6. doi: 10.7554/eLife.22693. PubMed
Structural and Molecular Mechanisms of Cytokine-Mediated Endocrine Resistance in Human Breast Cancer Cells. Stender JD, Nwachukwu JC, Kastrati I, Kim Y, Strid T, Yakir M, Srinivasan S, Nowak J, Izard T, Rangarajan ES, Carlson KE, Katzenellenbogen JA, Yao XQ, Grant BJ, Leong HS, Lin CY, Frasor J, Nettles KW, Glass CK. Mol Cell. 2017 Mar 16;65(6):1122-1135.e5. doi: 10.1016/j.molcel.2017.02.008. PubMed
PARK2 Depletion Connects Energy and Oxidative Stress to PI3K/Akt Activation via PTEN S-Nitrosylation. Gupta A, Anjomani-Virmouni S, Koundouros N, Dimitriadi M, Choo-Wing R, Valle A, Zheng Y, Chiu YH, Agnihotri S, Zadeh G, Asara JM, Anastasiou D, Arends MJ, Cantley LC, Poulogiannis G. Mol Cell. 2017 Mar 16;65(6):999-1013.e7. doi: 10.1016/j.molcel.2017.02.019. PubMed
Chd7 is indispensable for mammalian brain development through activation of a neuronal differentiation programme. Feng W, Kawauchi D, Korkel-Qu H, Deng H, Serger E, Sieber L, Lieberman JA, Jimeno-Gonzalez S, Lambo S, Hanna BS, Harim Y, Jansen M, Neuerburg A, Friesen O, Zuckermann M, Rajendran V, Gronych J, Ayrault O, Korshunov A, Jones DT, Kool M, Northcott PA, Lichter P, Cortes-Ledesma F, Pfister SM, Liu HK. Nat Commun. 2017 Mar 20;8:14758. doi: 10.1038/ncomms14758. PubMed
Genome-scale CRISPR-Cas9 knockout and transcriptional activation screening. Joung J, Konermann S, Gootenberg JS, Abudayyeh OO, Platt RJ, Brigham MD, Sanjana NE, Zhang F. Nat Protoc. 2017 Apr;12(4):828-863. doi: 10.1038/nprot.2017.016. Epub 2017 Mar 23. PubMed

Associated Plasmids

Mouse Mammary Tumor Virus Signal Peptide Uses a Novel p97-Dependent and Derlin-Independent Retrotranslocation Mechanism To Escape Proteasomal Degradation. Byun H, Das P, Yu H, Aleman A, Lozano MM, Matouschek A, Dudley JP. MBio. 2017 Mar 28;8(2). pii: e00328-17. doi: 10.1128/mBio.00328-17. PubMed
CRISPR-Cas9 Mediated Gene-Silencing of the Mutant Huntingtin Gene in an In Vitro Model of Huntington's Disease. Kolli N, Lu M, Maiti P, Rossignol J, Dunbar GL. Int J Mol Sci. 2017 Apr 2;18(4). pii: E754. doi: 10.3390/ijms18040754. PubMed
CRISPR-Cas9 epigenome editing enables high-throughput screening for functional regulatory elements in the human genome. Klann TS, Black JB, Chellappan M, Safi A, Song L, Hilton IB, Crawford GE, Reddy TE, Gersbach CA. Nat Biotechnol. 2017 Apr 3. doi: 10.1038/nbt.3853. PubMed

Associated Plasmids

Isolated polycystic liver disease genes define effectors of polycystin-1 function. Besse W, Dong K, Choi J, Punia S, Fedeles SV, Choi M, Gallagher AR, Huang EB, Gulati A, Knight J, Mane S, Tahvanainen E, Tahvanainen P, Sanna-Cherchi S, Lifton RP, Watnick T, Pei YP, Torres VE, Somlo S. J Clin Invest. 2017 May 1;127(5):1772-1785. doi: 10.1172/JCI90129. Epub 2017 Apr 4. PubMed
Hepatitis C virus triggers Golgi fragmentation and autophagy through the immunity-related GTPase M. Hansen MD, Johnsen IB, Stiberg KA, Sherstova T, Wakita T, Richard GM, Kandasamy RK, Meurs EF, Anthonsen MW. Proc Natl Acad Sci U S A. 2017 Apr 25;114(17):E3462-E3471. doi: 10.1073/pnas.1616683114. Epub 2017 Apr 7. PubMed
TLR sensing of bacterial spore-associated RNA triggers host immune responses with detrimental effects. Choo MK, Sano Y, Kim C, Yasuda K, Li XD, Lin X, Stenzel-Poore M, Alexopoulou L, Ghosh S, Latz E, Rifkin IR, Chen ZJ, Stewart GC, Chong H, Park JM. J Exp Med. 2017 May 1;214(5):1297-1311. doi: 10.1084/jem.20161141. Epub 2017 Apr 11. PubMed
Nucleotide-binding oligomerization domain (NOD) signaling defects and cell death susceptibility cannot be uncoupled in X-linked inhibitor of apoptosis (XIAP)-driven inflammatory disease. Chirieleison SM, Marsh RA, Kumar P, Rathkey JK, Dubyak GR, Abbott DW. J Biol Chem. 2017 Jun 9;292(23):9666-9679. doi: 10.1074/jbc.M117.781500. Epub 2017 Apr 12. PubMed
A tiling-deletion-based genetic screen for cis-regulatory element identification in mammalian cells. Diao Y, Fang R, Li B, Meng Z, Yu J, Qiu Y, Lin KC, Huang H, Liu T, Marina RJ, Jung I, Shen Y, Guan KL, Ren B. Nat Methods. 2017 Jun;14(6):629-635. doi: 10.1038/nmeth.4264. Epub 2017 Apr 17. PubMed
TAM Receptors Are Not Required for Zika Virus Infection in Mice. Hastings AK, Yockey LJ, Jagger BW, Hwang J, Uraki R, Gaitsch HF, Parnell LA, Cao B, Mysorekar IU, Rothlin CV, Fikrig E, Diamond MS, Iwasaki A. Cell Rep. 2017 Apr 18;19(3):558-568. doi: 10.1016/j.celrep.2017.03.058. PubMed
The miR-25-93-106b cluster regulates tumor metastasis and immune evasion via modulation of CXCL12 and PD-L1. Cioffi M, Trabulo SM, Vallespinos M, Raj D, Kheir TB, Lin ML, Begum J, Baker AM, Amgheib A, Saif J, Perez M, Soriano J, Desco M, Gomez-Gaviro MV, Cusso L, Megias D, Aicher A, Heeschen C. Oncotarget. 2017 Mar 28;8(13):21609-21625. doi: 10.18632/oncotarget.15450. PubMed
EBF2 transcriptionally regulates brown adipogenesis via the histone reader DPF3 and the BAF chromatin remodeling complex. Shapira SN, Lim HW, Rajakumari S, Sakers AP, Ishibashi J, Harms MJ, Won KJ, Seale P. Genes Dev. 2017 Apr 1;31(7):660-673. doi: 10.1101/gad.294405.116. Epub 2017 Apr 20. PubMed
SAMHD1 protects cancer cells from various nucleoside-based antimetabolites. Herold N, Rudd SG, Sanjiv K, Kutzner J, Bladh J, Paulin CBJ, Helleday T, Henter JI, Schaller T. Cell Cycle. 2017 Jun 3;16(11):1029-1038. doi: 10.1080/15384101.2017.1314407. Epub 2017 Apr 24. PubMed
Prominin-1 Is a Novel Regulator of Autophagy in the Human Retinal Pigment Epithelium. Bhattacharya S, Yin J, Winborn CS, Zhang Q, Yue J, Chaum E. Invest Ophthalmol Vis Sci. 2017 Apr 1;58(4):2366-2387. doi: 10.1167/iovs.16-21162. PubMed
Hepatitis C Virus Indirectly Disrupts DNA Damage-Induced p53 Responses by Activating Protein Kinase R. Mitchell JK, Midkiff BR, Israelow B, Evans MJ, Lanford RE, Walker CM, Lemon SM, McGivern DR. MBio. 2017 Apr 25;8(2). pii: e00121-17. doi: 10.1128/mBio.00121-17. PubMed
Sortilin and retromer mediate retrograde transport of Glut4 in 3T3-L1 adipocytes. Pan X, Zaarur N, Singh M, Morin P, Kandror KV. Mol Biol Cell. 2017 Jun 15;28(12):1667-1675. doi: 10.1091/mbc.E16-11-0777. Epub 2017 Apr 27. PubMed
Endophilin B2 facilitates endosome maturation in response to growth factor stimulation, autophagy induction, and influenza A virus infection. Serfass JM, Takahashi Y, Zhou Z, Kawasawa YI, Liu Y, Tsotakos N, Young MM, Tang Z, Yang L, Atkinson JM, Chroneos ZC, Wang HG. J Biol Chem. 2017 Jun 16;292(24):10097-10111. doi: 10.1074/jbc.M117.792747. Epub 2017 Apr 28. PubMed
A Novel Agonist of the TRIF Pathway Induces a Cellular State Refractory to Replication of Zika, Chikungunya, and Dengue Viruses. Pryke KM, Abraham J, Sali TM, Gall BJ, Archer I, Liu A, Bambina S, Baird J, Gough M, Chakhtoura M, Haddad EK, Kirby IT, Nilsen A, Streblow DN, Hirsch AJ, Smith JL, DeFilippis VR. MBio. 2017 May 2;8(3). pii: e00452-17. doi: 10.1128/mBio.00452-17. PubMed
mTORC1-independent autophagy regulates receptor tyrosine kinase phosphorylation in colorectal cancer cells via an mTORC2-mediated mechanism. Lampada A, O'Prey J, Szabadkai G, Ryan KM, Hochhauser D, Salomoni P. Cell Death Differ. 2017 Jun;24(6):1045-1062. doi: 10.1038/cdd.2017.41. Epub 2017 May 5. PubMed
Linear ubiquitination of cytosolic Salmonella Typhimurium activates NF-kappaB and restricts bacterial proliferation. van Wijk SJL, Fricke F, Herhaus L, Gupta J, Hotte K, Pampaloni F, Grumati P, Kaulich M, Sou YS, Komatsu M, Greten FR, Fulda S, Heilemann M, Dikic I. Nat Microbiol. 2017 May 8;2:17066. doi: 10.1038/nmicrobiol.2017.66. PubMed
p53 Maintains Baseline Expression of Multiple Tumor Suppressor Genes. Pappas K, Xu J, Zairis S, Resnick-Silverman L, Abate F, Steinbach N, Ozturk S, Saal LH, Su T, Cheung P, Schmidt H, Aaronson S, Hibshoosh H, Manfredi J, Rabadan R, Parsons R. Mol Cancer Res. 2017 May 8. doi: 10.1158/1541-7786.MCR-17-0089. PubMed
Type I and Type III Interferons Display Different Dependency on Mitogen-Activated Protein Kinases to Mount an Antiviral State in the Human Gut. Pervolaraki K, Stanifer ML, Munchau S, Renn LA, Albrecht D, Kurzhals S, Senis E, Grimm D, Schroder-Braunstein J, Rabin RL, Boulant S. Front Immunol. 2017 Apr 21;8:459. doi: 10.3389/fimmu.2017.00459. eCollection 2017. PubMed
IDH Mutation, Competitive Inhibition of FTO, and RNA Methylation. Elkashef SM, Lin AP, Myers J, Sill H, Jiang D, Dahia PLM, Aguiar RCT. Cancer Cell. 2017 May 8;31(5):619-620. doi: 10.1016/j.ccell.2017.04.001. PubMed
CHD4 Has Oncogenic Functions in Initiating and Maintaining Epigenetic Suppression of Multiple Tumor Suppressor Genes. Xia L, Huang W, Bellani M, Seidman MM, Wu K, Fan D, Nie Y, Cai Y, Zhang YW, Yu LR, Li H, Zahnow CA, Xie W, Chiu Yen RW, Rassool FV, Baylin SB. Cancer Cell. 2017 May 8;31(5):653-668.e7. doi: 10.1016/j.ccell.2017.04.005. PubMed
Intratumoural heterogeneity generated by Notch signalling promotes small-cell lung cancer. Lim JS, Ibaseta A, Fischer MM, Cancilla B, O'Young G, Cristea S, Luca VC, Yang D, Jahchan NS, Hamard C, Antoine M, Wislez M, Kong C, Cain J, Liu YW, Kapoun AM, Garcia KC, Hoey T, Murriel CL, Sage J. Nature. 2017 May 18;545(7654):360-364. doi: 10.1038/nature22323. Epub 2017 May 10. PubMed
Integrase-Deficient Lentiviral Vector as an All-in-One Platform for Highly Efficient CRISPR/Cas9-Mediated Gene Editing. Ortinski PI, O'Donovan B, Dong X, Kantor B. Mol Ther Methods Clin Dev. 2017 Apr 19;5:153-164. doi: 10.1016/j.omtm.2017.04.002. eCollection 2017 Jun 16. PubMed
E2F1 inhibits circulating cholesterol clearance by regulating Pcsk9 expression in the liver. Lai Q, Giralt A, Le May C, Zhang L, Cariou B, Denechaud PD, Fajas L. JCI Insight. 2017 May 18;2(10). pii: 89729. doi: 10.1172/jci.insight.89729. PubMed
Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function. Sakamaki JI, Wilkinson S, Hahn M, Tasdemir N, O'Prey J, Clark W, Hedley A, Nixon C, Long JS, New M, Van Acker T, Tooze SA, Lowe SW, Dikic I, Ryan KM. Mol Cell. 2017 May 18;66(4):517-532.e9. doi: 10.1016/j.molcel.2017.04.027. PubMed
Imatinib induces autophagy via upregulating XIAP in GIST882 cells. Xie Q, Lin Q, Li D, Chen J. Biochem Biophys Res Commun. 2017 Jul 8;488(4):584-589. doi: 10.1016/j.bbrc.2017.05.096. Epub 2017 May 18. PubMed
A novel isoform of TET1 that lacks a CXXC domain is overexpressed in cancer. Good CR, Madzo J, Patel B, Maegawa S, Engel N, Jelinek J, Issa JJ. Nucleic Acids Res. 2017 May 22. doi: 10.1093/nar/gkx435. PubMed
cGAS is essential for cellular senescence. Yang H, Wang H, Ren J, Chen Q, Chen ZJ. Proc Natl Acad Sci U S A. 2017 Jun 6;114(23):E4612-E4620. doi: 10.1073/pnas.1705499114. Epub 2017 May 22. PubMed
Heparan Sulfate Proteoglycan Is an Important Attachment Factor for Cell Entry of Akabane and Schmallenberg Viruses. Murakami S, Takenaka-Uema A, Kobayashi T, Kato K, Shimojima M, Palmarini M, Horimoto T. J Virol. 2017 Jul 12;91(15). pii: e00503-17. doi: 10.1128/JVI.00503-17. Print 2017 Aug 1. PubMed
Systematic discovery of mutation-specific synthetic lethals by mining pan-cancer human primary tumor data. Sinha S, Thomas D, Chan S, Gao Y, Brunen D, Torabi D, Reinisch A, Hernandez D, Chan A, Rankin EB, Bernards R, Majeti R, Dill DL. Nat Commun. 2017 May 31;8:15580. doi: 10.1038/ncomms15580. PubMed
Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals. Quiros PM, Prado MA, Zamboni N, D'Amico D, Williams RW, Finley D, Gygi SP, Auwerx J. J Cell Biol. 2017 Jul 3;216(7):2027-2045. doi: 10.1083/jcb.201702058. Epub 2017 May 31. PubMed
Hepatitis B virus X protein promotes CREB-mediated activation of miR-3188 and Notch signaling in hepatocellular carcinoma. Zhou SJ, Deng YL, Liang HF, Jaoude JC, Liu FY. Cell Death Differ. 2017 Sep;24(9):1577-1587. doi: 10.1038/cdd.2017.87. Epub 2017 Jun 2. PubMed
Monitoring of the spatial and temporal dynamics of BER/SSBR pathway proteins, including MYH, UNG2, MPG, NTH1 and NEIL1-3, during DNA replication. Bjoras KO, Sousa MML, Sharma A, Fonseca DM, Sogaard CK, Bjoras M, Otterlei M. Nucleic Acids Res. 2017 May 29. doi: 10.1093/nar/gkx476. PubMed
Epigenetic silencing of IRF1 dysregulates type III interferon responses to respiratory virus infection in epithelial to mesenchymal transition. Yang J, Tian B, Sun H, Garofalo RP, Brasier AR. Nat Microbiol. 2017 Jun 5;2:17086. doi: 10.1038/nmicrobiol.2017.86. PubMed
Regulator of Calcineurin 1 Gene Isoform 4, Down-regulated in Hepatocellular Carcinoma, Prevents Proliferation, Migration, and Invasive Activity of Cancer Cells and Metastasis of Orthotopic Tumors by Inhibiting Nuclear Translocation of NFAT1. Jin H, Wang C, Jin G, Ruan H, Gu D, Wei L, Wang H, Wang N, Arunachalam E, Zhang Y, Deng X, Yang C, Xiong Y, Feng H, Yao M, Fang J, Gu J, Cong W, Qin W. Gastroenterology. 2017 Sep;153(3):799-811.e33. doi: 10.1053/j.gastro.2017.05.045. Epub 2017 Jun 2. PubMed
ERRalpha Maintains Mitochondrial Oxidative Metabolism and Constitutes an Actionable Target in PGC1alpha-Elevated Melanomas. Luo C, Balsa E, Thomas A, Hatting M, Jedrychowski M, Gygi SP, Widlund HR, Puigserver P. Mol Cancer Res. 2017 Jun 8. doi: 10.1158/1541-7786.MCR-17-0143. PubMed
Simultaneous Knockout of CXCR4 and CCR5 Genes in CD4+ T Cells via CRISPR/Cas9 Confers Resistance to Both X4- and R5-Tropic Human Immunodeficiency Virus Type 1 Infection. Yu S, Yao Y, Xiao H, Li J, Liu Q, Yang Y, Adah D, Lu J, Zhao S, Qin L, Chen X. Hum Gene Ther. 2017 Jun 9. doi: 10.1089/hum.2017.032. PubMed
Sphingosine 1-Phosphate Lyase Enhances the Activation of IKKepsilon To Promote Type I IFN-Mediated Innate Immune Responses to Influenza A Virus Infection. Vijayan M, Xia C, Song YE, Ngo H, Studstill CJ, Drews K, Fox TE, Johnson MC, Hiscott J, Kester M, Alexander S, Hahm B. J Immunol. 2017 Jul 15;199(2):677-687. doi: 10.4049/jimmunol.1601959. Epub 2017 Jun 9. PubMed
Oncogenic K-Ras upregulates ITGA6 expression via FOSL1 to induce anoikis resistance and synergizes with alphaV-Class integrins to promote EMT. Zhang K, Myllymaki SM, Gao P, Devarajan R, Kytola V, Nykter M, Wei GH, Manninen A. Oncogene. 2017 Oct 12;36(41):5681-5694. doi: 10.1038/onc.2017.177. Epub 2017 Jun 12. PubMed

Associated Plasmids

Non-glycanated Decorin Is a Drug Target on Human Adipose Stromal Cells. Daquinag AC, Dadbin A, Snyder B, Wang X, Sahin AA, Ueno NT, Kolonin MG. Mol Ther Oncolytics. 2017 May 17;6:1-9. doi: 10.1016/j.omto.2017.05.003. eCollection 2017 Sep 15. PubMed
A novel combination treatment targeting BCL-XL and MCL1 for KRAS/BRAF-mutated and BCL2L1-amplified colorectal cancers. Cho SY, Han JY, Na D, Kang W, Lee A, Kim J, Lee J, Min S, Kang J, Chae J, Kim JI, Park H, Lee WS, Lee C. Mol Cancer Ther. 2017 Jun 13. pii: molcanther.0735.2016. doi: 10.1158/1535-7163.MCT-16-0735. PubMed
Activation of the ATF2/CREB-PGC-1alpha pathway by metformin leads to dopaminergic neuroprotection. Kang H, Khang R, Ham S, Jeong GR, Kim H, Jo M, Lee BD, Lee YI, Jo A, Park C, Kim H, Seo J, Paek SH, Lee YS, Choi JY, Lee Y, Shin JH. Oncotarget. 2017 Jul 25;8(30):48603-48618. doi: 10.18632/oncotarget.18122. PubMed
Germline factor DDX4 functions in blood-derived cancer cell phenotypes. Schudrowitz N, Takagi S, Wessel GM, Yajima M. Cancer Sci. 2017 Jun 14. doi: 10.1111/cas.13299. PubMed
ERF mutations reveal a balance of ETS factors controlling prostate oncogenesis. Bose R, Karthaus WR, Armenia J, Abida W, Iaquinta PJ, Zhang Z, Wongvipat J, Wasmuth EV, Shah N, Sullivan PS, Doran MG, Wang P, Patruno A, Zhao Y, Zheng D, Schultz N, Sawyers CL. Nature. 2017 Jun 29;546(7660):671-675. doi: 10.1038/nature22820. Epub 2017 Jun 14. PubMed
CRISPR/Cas9-mediated genome editing induces exon skipping by alternative splicing or exon deletion. Mou H, Smith JL, Peng L, Yin H, Moore J, Zhang XO, Song CQ, Sheel A, Wu Q, Ozata DM, Li Y, Anderson DG, Emerson CP, Sontheimer EJ, Moore MJ, Weng Z, Xue W. Genome Biol. 2017 Jun 14;18(1):108. doi: 10.1186/s13059-017-1237-8. PubMed
Correction of the Exon 2 Duplication in DMD Myoblasts by a Single CRISPR/Cas9 System. Lattanzi A, Duguez S, Moiani A, Izmiryan A, Barbon E, Martin S, Mamchaoui K, Mouly V, Bernardi F, Mavilio F, Bovolenta M. Mol Ther Nucleic Acids. 2017 Jun 16;7:11-19. doi: 10.1016/j.omtn.2017.02.004. Epub 2017 Feb 10. PubMed
A therapeutic T cell receptor mimic antibody targets tumor-associated PRAME peptide/HLA-I antigens. Chang AY, Dao T, Gejman RS, Jarvis CA, Scott A, Dubrovsky L, Mathias MD, Korontsvit T, Zakhaleva V, Curcio M, Hendrickson RC, Liu C, Scheinberg DA. J Clin Invest. 2017 Jun 30;127(7):2705-2718. doi: 10.1172/JCI92335. Epub 2017 Jun 19. PubMed
RBM25 is a global splicing factor promoting inclusion of alternatively spliced exons and is itself regulated by lysine mono-methylation. Carlson SM, Soulette CM, Yang Z, Elias JE, Brooks AN, Gozani O. J Biol Chem. 2017 Jun 27. pii: jbc.M117.784371. doi: 10.1074/jbc.M117.784371. PubMed
CRISPR/Cas9 targeting of GPRC6A suppresses prostate cancer tumorigenesis in a human xenograft model. Ye R, Pi M, Cox JV, Nishimoto SK, Quarles LD. J Exp Clin Cancer Res. 2017 Jun 28;36(1):90. doi: 10.1186/s13046-017-0561-x. PubMed
Mechanical cue-induced YAP instructs Skp2-dependent cell cycle exit and oncogenic signaling. Jang W, Kim T, Koo JS, Kim SK, Lim DS. EMBO J. 2017 Sep 1;36(17):2510-2528. doi: 10.15252/embj.201696089. Epub 2017 Jul 3. PubMed
Tumor Antigen and Receptor Densities Regulate Efficacy of a Chimeric Antigen Receptor Targeting Anaplastic Lymphoma Kinase. Walker AJ, Majzner RG, Zhang L, Wanhainen K, Long AH, Nguyen SM, Lopomo P, Vigny M, Fry TJ, Orentas RJ, Mackall CL. Mol Ther. 2017 Jul 1. pii: S1525-0016(17)30270-8. doi: 10.1016/j.ymthe.2017.06.008. PubMed
Transcription elongation factors represent in vivo cancer dependencies in glioblastoma. Miller TE, Liau BB, Wallace LC, Morton AR, Xie Q, Dixit D, Factor DC, Kim LJY, Morrow JJ, Wu Q, Mack SC, Hubert CG, Gillespie SM, Flavahan WA, Hoffmann T, Thummalapalli R, Hemann MT, Paddison PJ, Horbinski CM, Zuber J, Scacheri PC, Bernstein BE, Tesar PJ, Rich JN. Nature. 2017 Jul 20;547(7663):355-359. doi: 10.1038/nature23000. Epub 2017 Jul 5. PubMed
Argonaute Utilization for miRNA Silencing Is Determined by Phosphorylation-Dependent Recruitment of LIM-Domain-Containing Proteins. Bridge KS, Shah KM, Li Y, Foxler DE, Wong SCK, Miller DC, Davidson KM, Foster JG, Rose R, Hodgkinson MR, Ribeiro PS, Aboobaker AA, Yashiro K, Wang X, Graves PR, Plevin MJ, Lagos D, Sharp TV. Cell Rep. 2017 Jul 5;20(1):173-187. doi: 10.1016/j.celrep.2017.06.027. PubMed
Crosstalk between NRF2 and HIPK2 shapes cytoprotective responses. Torrente L, Sanchez C, Moreno R, Chowdhry S, Cabello P, Isono K, Koseki H, Honda T, Hayes JD, Dinkova-Kostova AT, de la Vega L. Oncogene. 2017 Jul 10. doi: 10.1038/onc.2017.221. PubMed
DGAT1-Dependent Lipid Droplet Biogenesis Protects Mitochondrial Function during Starvation-Induced Autophagy. Nguyen TB, Louie SM, Daniele JR, Tran Q, Dillin A, Zoncu R, Nomura DK, Olzmann JA. Dev Cell. 2017 Jul 10;42(1):9-21.e5. doi: 10.1016/j.devcel.2017.06.003. PubMed
A proteomic analysis of LRRK2 binding partners reveals interactions with multiple signaling components of the WNT/PCP pathway. Salasova A, Yokota C, Potesil D, Zdrahal Z, Bryja V, Arenas E. Mol Neurodegener. 2017 Jul 11;12(1):54. doi: 10.1186/s13024-017-0193-9. PubMed
A Role for Mitochondrial Translation in Promotion of Viability in K-Ras Mutant Cells. Martin TD, Cook DR, Choi MY, Li MZ, Haigis KM, Elledge SJ. Cell Rep. 2017 Jul 11;20(2):427-438. doi: 10.1016/j.celrep.2017.06.061. PubMed
Manipulation of nuclear architecture through CRISPR-mediated chromosomal looping. Morgan SL, Mariano NC, Bermudez A, Arruda NL, Wu F, Luo Y, Shankar G, Jia L, Chen H, Hu JF, Hoffman AR, Huang CC, Pitteri SJ, Wang KC. Nat Commun. 2017 Jul 13;8:15993. doi: 10.1038/ncomms15993. PubMed
Acylglycerol Kinase Mutated in Sengers Syndrome Is a Subunit of the TIM22 Protein Translocase in Mitochondria. Vukotic M, Nolte H, Konig T, Saita S, Ananjew M, Kruger M, Tatsuta T, Langer T. Mol Cell. 2017 Aug 3;67(3):471-483.e7. doi: 10.1016/j.molcel.2017.06.013. Epub 2017 Jul 14. PubMed
Cytosolic interaction of type III human CD38 with CIB1 modulates cellular cyclic ADP-ribose levels. Liu J, Zhao YJ, Li WH, Hou YN, Li T, Zhao ZY, Fang C, Li SL, Lee HC. Proc Natl Acad Sci U S A. 2017 Jul 18. pii: 1703718114. doi: 10.1073/pnas.1703718114. PubMed
Disrupted apical exocytosis of cargo vesicles causes enteropathy in FHL5 patients with Munc18-2 mutations. Vogel GF, van Rijn JM, Krainer IM, Janecke AR, Posovszky C, Cohen M, Searle C, Jantchou P, Escher JC, Patey N, Cutz E, Muller T, Middendorp S, Hess MW, Huber LA. JCI Insight. 2017 Jul 20;2(14). pii: 94564. doi: 10.1172/jci.insight.94564. PubMed
A time-resolved molecular map of the macrophage response to VSV infection. Kandasamy RK, Vladimer GI, Snijder B, Muller AC, Rebsamen M, Bigenzahn JW, Moskovskich A, Sabler M, Stefanovic A, Scorzoni S, Bruckner M, Penz T, Cleary C, Kralovics R, Colinge J, Bennett KL, Superti-Furga G. NPJ Syst Biol Appl. 2016 Oct 27;2:16027. doi: 10.1038/npjsba.2016.27. eCollection 2016. PubMed
Autophagy inhibition reduces chemoresistance and tumorigenic potential of human ovarian cancer stem cells. Pagotto A, Pilotto G, Mazzoldi EL, Nicoletto MO, Frezzini S, Pasto A, Amadori A. Cell Death Dis. 2017 Jul 20;8(7):e2943. doi: 10.1038/cddis.2017.327. PubMed
Deletion of transcription factor binding motifs using the CRISPR/spCas9 system in the beta-globin LCR. Kim YW, Kim A. Biosci Rep. 2017 Jul 20. pii: BSR20170976. doi: 10.1042/BSR20170976. PubMed
A CRISPR Resource for Individual, Combinatorial, or Multiplexed Gene Knockout. Erard N, Knott SRV, Hannon GJ. Mol Cell. 2017 Jul 20;67(2):348-354.e4. doi: 10.1016/j.molcel.2017.06.030. PubMed
BOK displays cell death-independent tumor suppressor activity in non-small-cell lung carcinoma. Moravcikova E, Krepela E, Donnenberg VS, Donnenberg AD, Benkova K, Rabachini T, Fernandez-Marrero Y, Bachmann D, Kaufmann T. Int J Cancer. 2017 Nov 15;141(10):2050-2061. doi: 10.1002/ijc.30906. Epub 2017 Aug 7. PubMed
Influenza virus recruits host protein kinase C to control assembly and activity of its replication machinery. Mondal A, Dawson AR, Potts GK, Freiberger EC, Baker SF, Moser LA, Bernard KA, Coon JJ, Mehle A. Elife. 2017 Jul 31;6. pii: 26910. doi: 10.7554/eLife.26910. PubMed
The tetraspanin CD9 facilitates MERS-coronavirus entry by scaffolding host cell receptors and proteases. Earnest JT, Hantak MP, Li K, McCray PB Jr, Perlman S, Gallagher T. PLoS Pathog. 2017 Jul 31;13(7):e1006546. doi: 10.1371/journal.ppat.1006546. eCollection 2017 Jul. PubMed
FBW7 Loss Promotes Chromosomal Instability and Tumorigenesis via Cyclin E1/CDK2-Mediated Phosphorylation of CENP-A. Takada M, Zhang W, Suzuki A, Kuroda TS, Yu Z, Inuzuka H, Gao D, Wan L, Zhuang M, Hu L, Zhai B, Fry CJ, Bloom K, Li G, Karpen GH, Wei W, Zhang Q. Cancer Res. 2017 Sep 15;77(18):4881-4893. doi: 10.1158/0008-5472.CAN-17-1240. Epub 2017 Jul 31. PubMed
A20 restores phorbol ester-induced differentiation of THP-1 cells in the absence of nuclear factor-kappaB activation. Osako M, Itsumi M, Yamaguchi H, Takeuchi H, Yamaoka S. J Cell Biochem. 2018 Feb;119(2):1475-1487. doi: 10.1002/jcb.26308. Epub 2017 Aug 28. PubMed
Interaction between von Hippel-Lindau Protein and Fatty Acid Synthase Modulates Hypoxia Target Gene Expression. Sun W, Kato H, Kitajima S, Lee KL, Gradin K, Okamoto T, Poellinger L. Sci Rep. 2017 Aug 3;7(1):7190. doi: 10.1038/s41598-017-05685-3. PubMed
Phospho-H1 Decorates the Inter-chromatid Axis and Is Evicted along with Shugoshin by SET during Mitosis. Krishnan S, Smits AH, Vermeulen M, Reinberg D. Mol Cell. 2017 Aug 17;67(4):579-593.e6. doi: 10.1016/j.molcel.2017.07.008. Epub 2017 Aug 3. PubMed
Genome-scale activation screen identifies a lncRNA locus regulating a gene neighbourhood. Joung J, Engreitz JM, Konermann S, Abudayyeh OO, Verdine VK, Aguet F, Gootenberg JS, Sanjana NE, Wright JB, Fulco CP, Tseng YY, Yoon CH, Boehm JS, Lander ES, Zhang F. Nature. 2017 Aug 11. doi: 10.1038/nature23451. PubMed
Effects of gene knockdown of CNP on ventricular remodeling after myocardial ischemia-reperfusion injury through NPRB/Cgmp signaling pathway in rats. Wu LH, Zhang Q, Zhang S, Meng LY, Wang YC, Sheng CJ. J Cell Biochem. 2018 Feb;119(2):1804-1818. doi: 10.1002/jcb.26341. Epub 2017 Sep 18. PubMed
Atg2A/B deficiency switches cytoprotective autophagy to non-canonical caspase-8 activation and apoptosis. Tang Z, Takahashi Y, Chen C, Liu Y, He H, Tsotakos N, Serfass JM, Gebru MT, Chen H, Young MM, Wang HG. Cell Death Differ. 2017 Dec;24(12):2127-2138. doi: 10.1038/cdd.2017.133. Epub 2017 Aug 11. PubMed
Exploiting Radiation-Induced Signaling to Increase the Susceptibility of Resistant Cancer Cells to Targeted Drugs: AKT and mTOR Inhibitors as an Example. Eke I, Makinde AY, Aryankalayil MJ, Sandfort V, Palayoor ST, Rath BH, Liotta L, Pierobon M, Petricoin EF, Brown MF, Stommel JM, Ahmed MM, Coleman CN. Mol Cancer Ther. 2018 Feb;17(2):355-367. doi: 10.1158/1535-7163.MCT-17-0262. Epub 2017 Aug 11. PubMed
Bisphosphoglycerate mutase controls serine pathway flux via 3-phosphoglycerate. Oslund RC, Su X, Haugbro M, Kee JM, Esposito M, David Y, Wang B, Ge E, Perlman DH, Kang Y, Muir TW, Rabinowitz JD. Nat Chem Biol. 2017 Oct;13(10):1081-1087. doi: 10.1038/nchembio.2453. Epub 2017 Aug 7. PubMed
Intrinsic BET inhibitor resistance in SPOP-mutated prostate cancer is mediated by BET protein stabilization and AKT-mTORC1 activation. Zhang P, Wang D, Zhao Y, Ren S, Gao K, Ye Z, Wang S, Pan CW, Zhu Y, Yan Y, Yang Y, Wu D, He Y, Zhang J, Lu D, Liu X, Yu L, Zhao S, Li Y, Lin D, Wang Y, Wang L, Chen Y, Sun Y, Wang C, Huang H. Nat Med. 2017 Sep;23(9):1055-1062. doi: 10.1038/nm.4379. Epub 2017 Aug 14. PubMed
Identification of CMTM6 and CMTM4 as PD-L1 protein regulators. Mezzadra R, Sun C, Jae LT, Gomez-Eerland R, de Vries E, Wu W, Logtenberg MEW, Slagter M, Rozeman EA, Hofland I, Broeks A, Horlings HM, Wessels LFA, Blank CU, Xiao Y, Heck AJR, Borst J, Brummelkamp TR, Schumacher TNM. Nature. 2017 Sep 7;549(7670):106-110. doi: 10.1038/nature23669. Epub 2017 Aug 16. PubMed
MTG16 is a tumor suppressor in colitis-associated carcinoma. McDonough EM, Barrett CW, Parang B, Mittal MK, Smith JJ, Bradley AM, Choksi YA, Coburn LA, Short SP, Thompson JJ, Zhang B, Poindexter SV, Fischer MA, Chen X, Li J, Revetta FL, Naik R, Washington MK, Rosen MJ, Hiebert SW, Wilson KT, Williams CS. JCI Insight. 2017 Aug 17;2(16). pii: 78210. doi: 10.1172/jci.insight.78210. PubMed
CRISPR/Cas9 editing reveals novel mechanisms of clustered microRNA regulation and function. Lataniotis L, Albrecht A, Kok FO, Monfries CAL, Benedetti L, Lawson ND, Hughes SM, Steinhofel K, Mayr M, Zampetaki A. Sci Rep. 2017 Aug 17;7(1):8585. doi: 10.1038/s41598-017-09268-0. PubMed
Synergy of WEE1 and mTOR Inhibition in Mutant KRAS-Driven Lung Cancers. Hai J, Liu S, Bufe L, Do K, Chen T, Wang X, Ng C, Li S, Tsao MS, Shapiro GI, Wong KK. Clin Cancer Res. 2017 Nov 15;23(22):6993-7005. doi: 10.1158/1078-0432.CCR-17-1098. Epub 2017 Aug 18. PubMed
LRRK2 promotes the activation of NLRC4 inflammasome during Salmonella Typhimurium infection. Liu W, Liu X, Li Y, Zhao J, Liu Z, Hu Z, Wang Y, Yao Y, Miller AW, Su B, Cookson MR, Li X, Kang Z. J Exp Med. 2017 Oct 2;214(10):3051-3066. doi: 10.1084/jem.20170014. Epub 2017 Aug 18. PubMed
Inactivation of Capicua in adult mice causes T-cell lymphoblastic lymphoma. Simon-Carrasco L, Grana O, Salmon M, Jacob HKC, Gutierrez A, Jimenez G, Drosten M, Barbacid M. Genes Dev. 2017 Jul 15;31(14):1456-1468. doi: 10.1101/gad.300244.117. Epub 2017 Aug 21. PubMed
Specific Expression of Interferon-gamma Induced by Synergistic Activation Mediator-Derived Systems Activates Innate Immunity and Inhibits Tumorigenesis. Liu S, Yu X, Wang Q, Liu Z, Xiao Q, Hou P, Hu Y, Hou W, Yang Z, Guo D, Chen S. J Microbiol Biotechnol. 2017 Oct 28;27(10):1855-1866. doi: 10.4014/jmb.1705.05081. PubMed
Mitochondrial permeabilization engages NF-kappaB-dependent anti-tumour activity under caspase deficiency. Giampazolias E, Zunino B, Dhayade S, Bock F, Cloix C, Cao K, Roca A, Lopez J, Ichim G, Proics E, Rubio-Patino C, Fort L, Yatim N, Woodham E, Orozco S, Taraborrelli L, Peltzer N, Lecis D, Machesky L, Walczak H, Albert ML, Milling S, Oberst A, Ricci JE, Ryan KM, Blyth K, Tait SWG. Nat Cell Biol. 2017 Sep;19(9):1116-1129. doi: 10.1038/ncb3596. Epub 2017 Aug 28. PubMed
Degradation of PHLPP2 by KCTD17, via a Glucagon-Dependent Pathway, Promotes Hepatic Steatosis. Kim K, Ryu D, Dongiovanni P, Ozcan L, Nayak S, Ueberheide B, Valenti L, Auwerx J, Pajvani UB. Gastroenterology. 2017 Dec;153(6):1568-1580.e10. doi: 10.1053/j.gastro.2017.08.039. Epub 2017 Aug 30. PubMed
Global Inhibition with Specific Activation: How p53 and MYC Redistribute the Transcriptome in the DNA Double-Strand Break Response. Porter JR, Fisher BE, Baranello L, Liu JC, Kambach DM, Nie Z, Koh WS, Luo J, Stommel JM, Levens D, Batchelor E. Mol Cell. 2017 Sep 21;67(6):1013-1025.e9. doi: 10.1016/j.molcel.2017.07.028. Epub 2017 Aug 31. PubMed
Salmonella Utilizes Zinc To Subvert Antimicrobial Host Defense of Macrophages via Modulation of NF-kappaB Signaling. Wu A, Tymoszuk P, Haschka D, Heeke S, Dichtl S, Petzer V, Seifert M, Hilbe R, Sopper S, Talasz H, Bumann D, Lass-Florl C, Theurl I, Zhang K, Weiss G. Infect Immun. 2017 Nov 17;85(12). pii: IAI.00418-17. doi: 10.1128/IAI.00418-17. Print 2017 Dec. PubMed
Human Herpesvirus 8 Interleukin-6 Interacts with Calnexin Cycle Components and Promotes Protein Folding. Chen D, Xiang Q, Nicholas J. J Virol. 2017 Oct 27;91(22). pii: JVI.00965-17. doi: 10.1128/JVI.00965-17. Print 2017 Nov 15. PubMed
Kinesin superfamily protein Kif26b links Wnt5a-Ror signaling to the control of cell and tissue behaviors in vertebrates. Susman MW, Karuna EP, Kunz RC, Gujral TS, Cantu AV, Choi SS, Jong BY, Okada K, Scales MK, Hum J, Hu LS, Kirschner MW, Nishinakamura R, Yamada S, Laird DJ, Jao LE, Gygi SP, Greenberg ME, Ho HH. Elife. 2017 Sep 8;6. pii: e26509. doi: 10.7554/eLife.26509. PubMed

Associated Plasmids

Centriole triplet microtubules are required for stable centriole formation and inheritance in human cells. Wang JT, Kong D, Hoerner CR, Loncarek J, Stearns T. Elife. 2017 Sep 14;6. pii: 29061. doi: 10.7554/eLife.29061. PubMed
Targeted Disruption of V600E-Mutant BRAF Gene by CRISPR-Cpf1. Yang M, Wei H, Wang Y, Deng J, Tang Y, Zhou L, Guo G, Tong A. Mol Ther Nucleic Acids. 2017 Sep 15;8:450-458. doi: 10.1016/j.omtn.2017.05.009. Epub 2017 May 17. PubMed
mTOR Inhibition Restores Amino Acid Balance in Cells Dependent on Catabolism of Extracellular Protein. Nofal M, Zhang K, Han S, Rabinowitz JD. Mol Cell. 2017 Sep 21;67(6):936-946.e5. doi: 10.1016/j.molcel.2017.08.011. Epub 2017 Sep 14. PubMed
ER-associated degradation is required for vasopressin prohormone processing and systemic water homeostasis. Shi G, Somlo DRM, Kim GH, Prescianotto-Baschong C, Sun S, Beuret N, Long Q, Rutishauser J, Arvan P, Spiess M, Qi L. J Clin Invest. 2017 Oct 2;127(10):3897-3912. doi: 10.1172/JCI94771. Epub 2017 Sep 18. PubMed
Priming and Activation of Inflammasome by Canarypox Virus Vector ALVAC via the cGAS/IFI16-STING-Type I IFN Pathway and AIM2 Sensor. Liu F, Niu Q, Fan X, Liu C, Zhang J, Wei Z, Hou W, Kanneganti TD, Robb ML, Kim JH, Michael NL, Sun J, Soong L, Hu H. J Immunol. 2017 Nov 1;199(9):3293-3305. doi: 10.4049/jimmunol.1700698. Epub 2017 Sep 25. PubMed
PHGDH as a Key Enzyme for Serine Biosynthesis in HIF2alpha-Targeting Therapy for Renal Cell Carcinoma. Yoshino H, Nohata N, Miyamoto K, Yonemori M, Sakaguchi T, Sugita S, Itesako T, Kofuji S, Nakagawa M, Dahiya R, Enokida H. Cancer Res. 2017 Nov 15;77(22):6321-6329. doi: 10.1158/0008-5472.CAN-17-1589. Epub 2017 Sep 26. PubMed
CG dinucleotide suppression enables antiviral defence targeting non-self RNA. Takata MA, Goncalves-Carneiro D, Zang TM, Soll SJ, York A, Blanco-Melo D, Bieniasz PD. Nature. 2017 Oct 5;550(7674):124-127. doi: 10.1038/nature24039. Epub 2017 Sep 27. PubMed
Genome-Wide CRISPR Screen for Essential Cell Growth Mediators in Mutant KRAS Colorectal Cancers. Yau EH, Kummetha IR, Lichinchi G, Tang R, Zhang Y, Rana TM. Cancer Res. 2017 Nov 15;77(22):6330-6339. doi: 10.1158/0008-5472.CAN-17-2043. Epub 2017 Sep 27. PubMed
Salt-inducible kinases (SIK) inhibition reduces RANKL-induced osteoclastogenesis. Lombardi MS, Gillieron C, Berkelaar M, Gabay C. PLoS One. 2017 Oct 3;12(10):e0185426. doi: 10.1371/journal.pone.0185426. eCollection 2017. PubMed
Implications of FGF19 on sorafenib-mediated nitric oxide production in hepatocellular carcinoma cells - a short report. Gao L, Shay C, Lv F, Wang X, Teng Y. Cell Oncol (Dordr). 2018 Feb;41(1):85-91. doi: 10.1007/s13402-017-0354-4. Epub 2017 Oct 5. PubMed
CRISPR-Cas9-mediated functional dissection of 3'-UTRs. Zhao W, Siegel D, Biton A, Tonqueze OL, Zaitlen N, Ahituv N, Erle DJ. Nucleic Acids Res. 2017 Oct 13;45(18):10800-10810. doi: 10.1093/nar/gkx675. PubMed
Innate immune recognition of double-stranded RNA triggers increased expression of NKG2D ligands after virus infection. Esteso G, Guerra S, Vales-Gomez M, Reyburn HT. J Biol Chem. 2017 Dec 15;292(50):20472-20480. doi: 10.1074/jbc.M117.818393. Epub 2017 Oct 6. PubMed
Replication defective viral genomes exploit a cellular pro-survival mechanism to establish paramyxovirus persistence. Xu J, Sun Y, Li Y, Ruthel G, Weiss SR, Raj A, Beiting D, Lopez CB. Nat Commun. 2017 Oct 6;8(1):799. doi: 10.1038/s41467-017-00909-6. PubMed
ATF4-Induced Metabolic Reprograming Is a Synthetic Vulnerability of the p62-Deficient Tumor Stroma. Linares JF, Cordes T, Duran A, Reina-Campos M, Valencia T, Ahn CS, Castilla EA, Moscat J, Metallo CM, Diaz-Meco MT. Cell Metab. 2017 Dec 5;26(6):817-829.e6. doi: 10.1016/j.cmet.2017.09.001. Epub 2017 Oct 5. PubMed
LAMTOR/Ragulator is a negative regulator of Arl8b- and BORC-dependent late endosomal positioning. Filipek PA, de Araujo MEG, Vogel GF, De Smet CH, Eberharter D, Rebsamen M, Rudashevskaya EL, Kremser L, Yordanov T, Tschaikner P, Furnrohr BG, Lechner S, Dunzendorfer-Matt T, Scheffzek K, Bennett KL, Superti-Furga G, Lindner HH, Stasyk T, Huber LA. J Cell Biol. 2017 Dec 4;216(12):4199-4215. doi: 10.1083/jcb.201703061. Epub 2017 Oct 9. PubMed
A Large-Scale RNAi Screen Identifies SGK1 as a Key Survival Kinase for GBM Stem Cells. Kulkarni S, Goel-Bhattacharya S, Sengupta S, Cochran BH. Mol Cancer Res. 2018 Jan;16(1):103-114. doi: 10.1158/1541-7786.MCR-17-0146. Epub 2017 Oct 9. PubMed
Androgen Receptor Pathway-Independent Prostate Cancer Is Sustained through FGF Signaling. Bluemn EG, Coleman IM, Lucas JM, Coleman RT, Hernandez-Lopez S, Tharakan R, Bianchi-Frias D, Dumpit RF, Kaipainen A, Corella AN, Yang YC, Nyquist MD, Mostaghel E, Hsieh AC, Zhang X, Corey E, Brown LG, Nguyen HM, Pienta K, Ittmann M, Schweizer M, True LD, Wise D, Rennie PS, Vessella RL, Morrissey C, Nelson PS. Cancer Cell. 2017 Oct 9;32(4):474-489.e6. doi: 10.1016/j.ccell.2017.09.003. PubMed
Diverse Viruses Require the Calcium Transporter SPCA1 for Maturation and Spread. Hoffmann HH, Schneider WM, Blomen VA, Scull MA, Hovnanian A, Brummelkamp TR, Rice CM. Cell Host Microbe. 2017 Oct 11;22(4):460-470.e5. doi: 10.1016/j.chom.2017.09.002. PubMed
Ebola virus requires phosphatidylinositol (3,5) bisphosphate production for efficient viral entry. Qiu S, Leung A, Bo Y, Kozak RA, Anand SP, Warkentin C, Salambanga FDR, Cui J, Kobinger G, Kobasa D, Cote M. Virology. 2018 Jan 1;513:17-28. doi: 10.1016/j.virol.2017.09.028. Epub 2017 Oct 12. PubMed
CRISPR/Cas9-mediated gene knockout is insensitive to target copy number but is dependent on guide RNA potency and Cas9/sgRNA threshold expression level. Yuen G, Khan FJ, Gao S, Stommel JM, Batchelor E, Wu X, Luo J. Nucleic Acids Res. 2017 Nov 16;45(20):12039-12053. doi: 10.1093/nar/gkx843. PubMed
TRIM29 promotes DNA virus infections by inhibiting innate immune response. Xing J, Zhang A, Zhang H, Wang J, Li XC, Zeng MS, Zhang Z. Nat Commun. 2017 Oct 16;8(1):945. doi: 10.1038/s41467-017-00101-w. PubMed
Regulation of NOTCH signaling by RAB7 and RAB8 requires carboxyl methylation by ICMT. Court H, Ahearn IM, Amoyel M, Bach EA, Philips MR. J Cell Biol. 2017 Dec 4;216(12):4165-4182. doi: 10.1083/jcb.201701053. Epub 2017 Oct 19. PubMed
Epithelial-to-Mesenchymal Transition Antagonizes Response to Targeted Therapies in Lung Cancer by Suppressing BIM. Song KA, Niederst MJ, Lochmann TL, Hata AN, Kitai H, Ham J, Floros KV, Hicks MA, Hu H, Mulvey HE, Drier Y, Heisey DAR, Hughes MT, Patel NU, Lockerman EL, Garcia A, Gillepsie S, Archibald HL, Gomez-Caraballo M, Nulton TJ, Windle BE, Piotrowska Z, Sahingur SE, Taylor SM, Dozmorov M, Sequist LV, Bernstein B, Ebi H, Engelman JA, Faber AC. Clin Cancer Res. 2018 Jan 1;24(1):197-208. doi: 10.1158/1078-0432.CCR-17-1577. Epub 2017 Oct 19. PubMed
Virus-Mediated Genome Editing via Homology-Directed Repair in Mitotic and Postmitotic Cells in Mammalian Brain. Nishiyama J, Mikuni T, Yasuda R. Neuron. 2017 Oct 18. pii: S0896-6273(17)30933-9. doi: 10.1016/j.neuron.2017.10.004. PubMed

Associated Plasmids

The Human Knockout Gene CLYBL Connects Itaconate to Vitamin B12. Shen H, Campanello GC, Flicker D, Grabarek Z, Hu J, Luo C, Banerjee R, Mootha VK. Cell. 2017 Nov 2;171(4):771-782.e11. doi: 10.1016/j.cell.2017.09.051. Epub 2017 Oct 19. PubMed

Associated Plasmids

Rac3 regulates breast cancer invasion and metastasis by controlling adhesion and matrix degradation. Donnelly SK, Cabrera R, Mao SPH, Christin JR, Wu B, Guo W, Bravo-Cordero JJ, Condeelis JS, Segall JE, Hodgson L. J Cell Biol. 2017 Dec 4;216(12):4331-4349. doi: 10.1083/jcb.201704048. Epub 2017 Oct 23. PubMed
UTX-guided neural crest function underlies craniofacial features of Kabuki syndrome. Shpargel KB, Starmer J, Wang C, Ge K, Magnuson T. Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):E9046-E9055. doi: 10.1073/pnas.1705011114. Epub 2017 Oct 9. PubMed
Transcription factor c-Myb inhibits breast cancer lung metastasis by suppression of tumor cell seeding. Knopfova L, Biglieri E, Volodko N, Masarik M, Hermanova M, Glaus Garzon JF, Ducka M, Kucirkova T, Soucek K, Smarda J, Benes P, Borsig L. Oncogene. 2018 Feb 22;37(8):1020-1030. doi: 10.1038/onc.2017.392. Epub 2017 Oct 30. PubMed
Role of lysosomal channel protein TPC2 in osteoclast differentiation and bone remodeling under normal and low-magnesium conditions. Notomi T, Kuno M, Hiyama A, Nozaki T, Ohura K, Ezura Y, Noda M. J Biol Chem. 2017 Dec 22;292(51):20998-21010. doi: 10.1074/jbc.M117.780072. Epub 2017 Oct 30. PubMed
Activation of CaMKIIgamma potentiates T-cell acute lymphoblastic leukemia leukemogenesis via phosphorylating FOXO3a. Jiang X, Wu Z, Lu X, Zhang X, Yu Q, Gan Y, Wu B, Xu Y, Zheng W, Zhang L, Xu F, Ma A, Gan X, Huang S, Yu X, Huang W, Xu R. Oncotarget. 2017 Aug 24;8(43):75050-75064. doi: 10.18632/oncotarget.20504. eCollection 2017 Sep 26. PubMed
Aberrant GATA2 epigenetic dysregulation induces a GATA2/GATA6 switch in human gastric cancer. Song SH, Jeon MS, Nam JW, Kang JK, Lee YJ, Kang JY, Kim HP, Han SW, Kang GH, Kim TY. Oncogene. 2018 Feb 22;37(8):993-1004. doi: 10.1038/onc.2017.397. Epub 2017 Nov 6. PubMed
Nuclear TRIM25 Specifically Targets Influenza Virus Ribonucleoproteins to Block the Onset of RNA Chain Elongation. Meyerson NR, Zhou L, Guo YR, Zhao C, Tao YJ, Krug RM, Sawyer SL. Cell Host Microbe. 2017 Nov 8;22(5):627-638.e7. doi: 10.1016/j.chom.2017.10.003. Epub 2017 Nov 5. PubMed
Serum squamous cell carcinoma antigen as an early indicator of response during therapy of cervical cancer. Markovina S, Wang S, Henke LE, Luke CJ, Pak SC, DeWees T, Pfeifer JD, Schwarz JK, Liu W, Chen S, Mutch D, Wang X, Powell MA, Siegel BA, Dehdashti F, Silverman GA, Grigsby PW. Br J Cancer. 2018 Jan;118(1):72-78. doi: 10.1038/bjc.2017.390. Epub 2017 Nov 7. PubMed
CRISPR-mediated deletion of the PECAM-1 cytoplasmic domain increases receptor lateral mobility and strengthens endothelial cell junctional integrity. Liao D, Mei H, Hu Y, Newman DK, Newman PJ. Life Sci. 2018 Jan 15;193:186-193. doi: 10.1016/j.lfs.2017.11.002. Epub 2017 Nov 6. PubMed
CRISPR-mediated TCR replacement generates superior anticancer transgenic T cells. Legut M, Dolton G, Mian AA, Ottmann OG, Sewell AK. Blood. 2018 Jan 18;131(3):311-322. doi: 10.1182/blood-2017-05-787598. Epub 2017 Nov 9. PubMed
A Map of Human Mitochondrial Protein Interactions Linked to Neurodegeneration Reveals New Mechanisms of Redox Homeostasis and NF-kappaB Signaling. Malty RH, Aoki H, Kumar A, Phanse S, Amin S, Zhang Q, Minic Z, Goebels F, Musso G, Wu Z, Abou-Tok H, Meyer M, Deineko V, Kassir S, Sidhu V, Jessulat M, Scott NE, Xiong X, Vlasblom J, Prasad B, Foster LJ, Alberio T, Garavaglia B, Yu H, Bader GD, Nakamura K, Parkinson J, Babu M. Cell Syst. 2017 Nov 7. pii: S2405-4712(17)30447-7. doi: 10.1016/j.cels.2017.10.010. PubMed

Associated Plasmids

Kinase profiling of liposarcomas using RNAi and drug screening assays identified druggable targets. Kanojia D, Garg M, Martinez J, M T A, Luty SB, Doan NB, Said JW, Forscher C, Tyner JW, Koeffler HP. J Hematol Oncol. 2017 Nov 13;10(1):173. doi: 10.1186/s13045-017-0540-x. PubMed
Genome modification of CXCR4 by Staphylococcus aureus Cas9 renders cells resistance to HIV-1 infection. Wang Q, Chen S, Xiao Q, Liu Z, Liu S, Hou P, Zhou L, Hou W, Ho W, Li C, Wu L, Guo D. Retrovirology. 2017 Nov 15;14(1):51. doi: 10.1186/s12977-017-0375-0. PubMed
CD22-targeted CAR T cells induce remission in B-ALL that is naive or resistant to CD19-targeted CAR immunotherapy. Fry TJ, Shah NN, Orentas RJ, Stetler-Stevenson M, Yuan CM, Ramakrishna S, Wolters P, Martin S, Delbrook C, Yates B, Shalabi H, Fountaine TJ, Shern JF, Majzner RG, Stroncek DF, Sabatino M, Feng Y, Dimitrov DS, Zhang L, Nguyen S, Qin H, Dropulic B, Lee DW, Mackall CL. Nat Med. 2018 Jan;24(1):20-28. doi: 10.1038/nm.4441. Epub 2017 Nov 20. PubMed
A RasGAP, DAB2IP, regulates lipid droplet homeostasis by serving as GAP toward RAB40C. Luo X, Li C, Tan R, Xu X, Wu WKK, Satoh A, Wang T, Yu S. Oncotarget. 2017 Aug 3;8(49):85415-85427. doi: 10.18632/oncotarget.19960. eCollection 2017 Oct 17. PubMed
EMT programs promote basal mammary stem cell and tumor-initiating cell stemness by inducing primary ciliogenesis and Hedgehog signaling. Guen VJ, Chavarria TE, Kroger C, Ye X, Weinberg RA, Lees JA. Proc Natl Acad Sci U S A. 2017 Dec 5;114(49):E10532-E10539. doi: 10.1073/pnas.1711534114. Epub 2017 Nov 20. PubMed
PDGFRalpha/PDGFRbeta signaling balance modulates progenitor cell differentiation into white and beige adipocytes. Gao Z, Daquinag AC, Su F, Snyder B, Kolonin MG. Development. 2018 Jan 4;145(1). pii: dev.155861. doi: 10.1242/dev.155861. PubMed
A non-canonical Notch complex regulates adherens junctions and vascular barrier function. Polacheck WJ, Kutys ML, Yang J, Eyckmans J, Wu Y, Vasavada H, Hirschi KK, Chen CS. Nature. 2017 Dec 14;552(7684):258-262. doi: 10.1038/nature24998. Epub 2017 Nov 13. PubMed
3D collagen architecture induces a conserved migratory and transcriptional response linked to vasculogenic mimicry. Velez DO, Tsui B, Goshia T, Chute CL, Han A, Carter H, Fraley SI. Nat Commun. 2017 Nov 21;8(1):1651. doi: 10.1038/s41467-017-01556-7. PubMed
Nicotinic Acetylcholine Receptor Subtype Alpha-9 Mediates Triple-Negative Breast Cancers Based on a Spontaneous Pulmonary Metastasis Mouse Model. Huang LC, Lin CL, Qiu JZ, Lin CY, Hsu KW, Tam KW, Lee JY, Yang JM, Lee CH. Front Cell Neurosci. 2017 Nov 3;11:336. doi: 10.3389/fncel.2017.00336. eCollection 2017. PubMed
ETS1 induction by the microenvironment promotes ovarian cancer metastasis through focal adhesion kinase. Tomar S, Plotnik JP, Haley J, Scantland J, Dasari S, Sheikh Z, Emerson R, Lenz D, Hollenhorst PC, Mitra AK. Cancer Lett. 2018 Feb 1;414:190-204. doi: 10.1016/j.canlet.2017.11.012. Epub 2017 Nov 22. PubMed
Nutlin sensitizes lung carcinoma cells to interferon-alpha treatment in MDM2-dependent but p53-independent manner. Shuvalov O, Kizenko A, Shakirova A, Fedorova O, Petukhov A, Aksenov N, Vasileva E, Daks A, Barlev N. Biochem Biophys Res Commun. 2018 Jan 1;495(1):1233-1239. doi: 10.1016/j.bbrc.2017.11.118. Epub 2017 Nov 23. PubMed
Bicaudal D2 facilitates the cytoplasmic trafficking and nuclear import of HIV-1 genomes during infection. Dharan A, Opp S, Abdel-Rahim O, Keceli SK, Imam S, Diaz-Griffero F, Campbell EM. Proc Natl Acad Sci U S A. 2017 Dec 12;114(50):E10707-E10716. doi: 10.1073/pnas.1712033114. Epub 2017 Nov 27. PubMed
The IFN Response in Bats Displays Distinctive IFN-Stimulated Gene Expression Kinetics with Atypical RNASEL Induction. De La Cruz-Rivera PC, Kanchwala M, Liang H, Kumar A, Wang LF, Xing C, Schoggins JW. J Immunol. 2018 Jan 1;200(1):209-217. doi: 10.4049/jimmunol.1701214. Epub 2017 Nov 27. PubMed
Inactivation of DNA repair triggers neoantigen generation and impairs tumour growth. Germano G, Lamba S, Rospo G, Barault L, Magri A, Maione F, Russo M, Crisafulli G, Bartolini A, Lerda G, Siravegna G, Mussolin B, Frapolli R, Montone M, Morano F, de Braud F, Amirouchene-Angelozzi N, Marsoni S, D'Incalci M, Orlandi A, Giraudo E, Sartore-Bianchi A, Siena S, Pietrantonio F, Di Nicolantonio F, Bardelli A. Nature. 2017 Dec 7;552(7683):116-120. doi: 10.1038/nature24673. Epub 2017 Nov 29. PubMed
Identification of a Raloxifene Analog That Promotes AhR-Mediated Apoptosis in Cancer Cells. Jang HS, Pearce M, O'Donnell EF, Nguyen BD, Truong L, Mueller MJ, Bisson WH, Kerkvliet NI, Tanguay RL, Kolluri SK. Biology (Basel). 2017 Dec 1;6(4). pii: biology6040041. doi: 10.3390/biology6040041. PubMed
The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages. Evavold CL, Ruan J, Tan Y, Xia S, Wu H, Kagan JC. Immunity. 2018 Jan 16;48(1):35-44.e6. doi: 10.1016/j.immuni.2017.11.013. Epub 2017 Nov 28. PubMed
Single-Cell Transcriptomic Analysis of Primary and Metastatic Tumor Ecosystems in Head and Neck Cancer. Puram SV, Tirosh I, Parikh AS, Patel AP, Yizhak K, Gillespie S, Rodman C, Luo CL, Mroz EA, Emerick KS, Deschler DG, Varvares MA, Mylvaganam R, Rozenblatt-Rosen O, Rocco JW, Faquin WC, Lin DT, Regev A, Bernstein BE. Cell. 2017 Dec 14;171(7):1611-1624.e24. doi: 10.1016/j.cell.2017.10.044. Epub 2017 Nov 30. PubMed
LDB2 inhibits proliferation and migration in liver cancer cells by abrogating HEY1 expression. Yu H, Jia R, Zhao L, Song S, Gu J, Zhang H. Oncotarget. 2017 Oct 10;8(55):94440-94449. doi: 10.18632/oncotarget.21772. eCollection 2017 Nov 7. PubMed
Syndecan-1 promotes Wnt/beta-catenin signaling in multiple myeloma by presenting Wnts and R-spondins. Ren Z, van Andel H, de Lau W, Hartholt RB, Maurice MM, Clevers H, Kersten MJ, Spaargaren M, Pals ST. Blood. 2018 Mar 1;131(9):982-994. doi: 10.1182/blood-2017-07-797050. Epub 2017 Dec 6. PubMed
Role of Dopamine Receptors in the Anticancer Activity of ONC201. Kline CLB, Ralff MD, Lulla AR, Wagner JM, Abbosh PH, Dicker DT, Allen JE, El-Deiry WS. Neoplasia. 2018 Jan;20(1):80-91. doi: 10.1016/j.neo.2017.10.002. Epub 2017 Dec 5. PubMed
Tumor suppressor p53 links ceramide metabolism to DNA damage response through alkaline ceramidase 2. Xu R, Garcia-Barros M, Wen S, Li F, Lin CL, Hannun YA, Obeid LM, Mao C. Cell Death Differ. 2018 May;25(5):841-856. doi: 10.1038/s41418-017-0018-y. Epub 2017 Dec 11. PubMed
Therapeutic relevance of the PP2A-B55 inhibitory kinase MASTL/Greatwall in breast cancer. Alvarez-Fernandez M, Sanz-Flores M, Sanz-Castillo B, Salazar-Roa M, Partida D, Zapatero-Solana E, Ali HR, Manchado E, Lowe S, VanArsdale T, Shields D, Caldas C, Quintela-Fandino M, Malumbres M. Cell Death Differ. 2017 Dec 11. pii: 10.1038/s41418-017-0024-0. doi: 10.1038/s41418-017-0024-0. PubMed
Autophagy induced during apoptosis degrades mitochondria and inhibits type I interferon secretion. Lindqvist LM, Frank D, McArthur K, Dite TA, Lazarou M, Oakhill JS, Kile BT, Vaux DL. Cell Death Differ. 2018 Mar;25(4):784-796. doi: 10.1038/s41418-017-0017-z. Epub 2017 Dec 11. PubMed
Probing the requirement for CD38 in retinoic acid-induced HL-60 cell differentiation with a small molecule dimerizer and genetic knockout. MacDonald RJ, Shrimp JH, Jiang H, Zhang L, Lin H, Yen A. Sci Rep. 2017 Dec 12;7(1):17406. doi: 10.1038/s41598-017-17720-4. PubMed
Endothelial-derived interleukin-6 induces cancer stem cell motility by generating a chemotactic gradient towards blood vessels. Kim HS, Chen YC, Nor F, Warner KA, Andrews A, Wagner VP, Zhang Z, Zhang Z, Martins MD, Pearson AT, Yoon E, Nor JE. Oncotarget. 2017 Nov 1;8(59):100339-100352. doi: 10.18632/oncotarget.22225. eCollection 2017 Nov 21. PubMed
In Vivo Knockout of the Vegfa Gene by Lentiviral Delivery of CRISPR/Cas9 in Mouse Retinal Pigment Epithelium Cells. Holmgaard A, Askou AL, Benckendorff JNE, Thomsen EA, Cai Y, Bek T, Mikkelsen JG, Corydon TJ. Mol Ther Nucleic Acids. 2017 Dec 15;9:89-99. doi: 10.1016/j.omtn.2017.08.016. Epub 2017 Sep 21. PubMed
Cell-penetrating peptides derived from Clostridium difficile TcdB2 and a related large clostridial toxin. Larabee JL, Hauck GD, Ballard JD. J Biol Chem. 2018 Feb 2;293(5):1810-1819. doi: 10.1074/jbc.M117.815373. Epub 2017 Dec 15. PubMed
Coronaviruses and arteriviruses display striking differences in their cyclophilin A-dependence during replication in cell culture. de Wilde AH, Zevenhoven-Dobbe JC, Beugeling C, Chatterji U, de Jong D, Gallay P, Szuhai K, Posthuma CC, Snijder EJ. Virology. 2018 Apr;517:148-156. doi: 10.1016/j.virol.2017.11.022. Epub 2017 Dec 15. PubMed
R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m(6)A/MYC/CEBPA Signaling. Su R, Dong L, Li C, Nachtergaele S, Wunderlich M, Qing Y, Deng X, Wang Y, Weng X, Hu C, Yu M, Skibbe J, Dai Q, Zou D, Wu T, Yu K, Weng H, Huang H, Ferchen K, Qin X, Zhang B, Qi J, Sasaki AT, Plas DR, Bradner JE, Wei M, Marcucci G, Jiang X, Mulloy JC, Jin J, He C, Chen J. Cell. 2018 Jan 11;172(1-2):90-105.e23. doi: 10.1016/j.cell.2017.11.031. Epub 2017 Dec 14. PubMed

Associated Plasmids

The PLAG1-GDH1 Axis Promotes Anoikis Resistance and Tumor Metastasis through CamKK2-AMPK Signaling in LKB1-Deficient Lung Cancer. Jin L, Chun J, Pan C, Kumar A, Zhang G, Ha Y, Li D, Alesi GN, Kang Y, Zhou L, Yu WM, Magliocca KR, Khuri FR, Qu CK, Metallo C, Owonikoko TK, Kang S. Mol Cell. 2018 Jan 4;69(1):87-99.e7. doi: 10.1016/j.molcel.2017.11.025. Epub 2017 Dec 14. PubMed
FOXC1-induced non-canonical WNT5A-MMP7 signaling regulates invasiveness in triple-negative breast cancer. Han B, Zhou B, Qu Y, Gao B, Xu Y, Chung S, Tanaka H, Yang W, Giuliano AE, Cui X. Oncogene. 2018 Mar;37(10):1399-1408. doi: 10.1038/s41388-017-0021-2. Epub 2017 Dec 18. PubMed
Histone deacetylase 6 (HDAC6) deacetylates extracellular signal-regulated kinase 1 (ERK1) and thereby stimulates ERK1 activity. Wu JY, Xiang S, Zhang M, Fang B, Huang H, Kwon OK, Zhao Y, Yang Z, Bai W, Bepler G, Zhang XM. J Biol Chem. 2018 Feb 9;293(6):1976-1993. doi: 10.1074/jbc.M117.795955. Epub 2017 Dec 19. PubMed
Cucurbitacin B and SCH772984 exhibit synergistic anti-pancreatic cancer activities by suppressing EGFR, PI3K/Akt/mTOR, STAT3 and ERK signaling. Zhou J, Zhao T, Ma L, Liang M, Guo YJ, Zhao LM. Oncotarget. 2017 Oct 9;8(61):103167-103181. doi: 10.18632/oncotarget.21704. eCollection 2017 Nov 28. PubMed
Emerging Alphaviruses Are Sensitive to Cellular States Induced by a Novel Small-Molecule Agonist of the STING Pathway. Gall B, Pryke K, Abraham J, Mizuno N, Botto S, Sali TM, Broeckel R, Haese N, Nilsen A, Placzek A, Morrison T, Heise M, Streblow D, DeFilippis V. J Virol. 2018 Feb 26;92(6). pii: JVI.01913-17. doi: 10.1128/JVI.01913-17. Print 2018 Mar 15. PubMed
A Protocol for the Production of Integrase-deficient Lentiviral Vectors for CRISPR/Cas9-mediated Gene Knockout in Dividing Cells. Vijayraghavan S, Kantor B. J Vis Exp. 2017 Dec 12;(130). doi: 10.3791/56915. PubMed
The role of host DNA ligases in hepadnavirus covalently closed circular DNA formation. Long Q, Yan R, Hu J, Cai D, Mitra B, Kim ES, Marchetti A, Zhang H, Wang S, Liu Y, Huang A, Guo H. PLoS Pathog. 2017 Dec 29;13(12):e1006784. doi: 10.1371/journal.ppat.1006784. eCollection 2017 Dec. PubMed
The p38 Mitogen-Activated Protein Kinase Critically Regulates Human Keratinocyte Inflammasome Activation. Fenini G, Grossi S, Gehrke S, Beer HD, Satoh TK, Contassot E, French LE. J Invest Dermatol. 2018 Jun;138(6):1380-1390. doi: 10.1016/j.jid.2017.10.037. Epub 2017 Dec 26. PubMed
CRISPR Screens Uncover Genes that Regulate Target Cell Sensitivity to the Morphogen Sonic Hedgehog. Pusapati GV, Kong JH, Patel BB, Krishnan A, Sagner A, Kinnebrew M, Briscoe J, Aravind L, Rohatgi R. Dev Cell. 2018 Jan 8;44(1):113-129.e8. doi: 10.1016/j.devcel.2017.12.003. Epub 2017 Dec 28. PubMed
Scarless Genome Editing of Human Pluripotent Stem Cells via Transient Puromycin Selection. Steyer B, Bu Q, Cory E, Jiang K, Duong S, Sinha D, Steltzer S, Gamm D, Chang Q, Saha K. Stem Cell Reports. 2018 Feb 13;10(2):642-654. doi: 10.1016/j.stemcr.2017.12.004. Epub 2018 Jan 4. PubMed
DEPDC5 deficiency contributes to resistance to leucine starvation via p62 accumulation in hepatocellular carcinoma. Mizuno Y, Shimada S, Akiyama Y, Watanabe S, Aida T, Ogawa K, Ono H, Mitsunori Y, Ban D, Kudo A, Arii S, Yamaoka S, Tanabe M, Tanaka S. Sci Rep. 2018 Jan 8;8(1):106. doi: 10.1038/s41598-017-18323-9. PubMed
Combined shRNA over CRISPR/cas9 as a methodology to detect off-target effects and a potential compensatory mechanism. Peretz L, Besser E, Hajbi R, Casden N, Ziv D, Kronenberg N, Gigi LB, Sweetat S, Khawaled S, Aqeilan R, Behar O. Sci Rep. 2018 Jan 8;8(1):93. doi: 10.1038/s41598-017-18551-z. PubMed
Force Generation via beta-Cardiac Myosin, Titin, and alpha-Actinin Drives Cardiac Sarcomere Assembly from Cell-Matrix Adhesions. Chopra A, Kutys ML, Zhang K, Polacheck WJ, Sheng CC, Luu RJ, Eyckmans J, Hinson JT, Seidman JG, Seidman CE, Chen CS. Dev Cell. 2018 Jan 8;44(1):87-96.e5. doi: 10.1016/j.devcel.2017.12.012. Epub 2018 Jan 8. PubMed
Modest Decreases in Endogenous All-trans-Retinoic Acid Produced by a Mouse Rdh10 Heterozygote Provoke Major Abnormalities in Adipogenesis and Lipid Metabolism. Yang D, Vuckovic MG, Smullin CP, Kim M, Lo CP, Devericks E, Yoo HS, Tintcheva M, Deng Y, Napoli JL. Diabetes. 2018 Apr;67(4):662-673. doi: 10.2337/db17-0946. Epub 2018 Jan 10. PubMed
An intrinsic lipid-binding interface controls sphingosine kinase 1 function. Pulkoski-Gross MJ, Jenkins ML, Truman JP, Salama MF, Clarke CJ, Burke JE, Hannun YA, Obeid LM. J Lipid Res. 2018 Mar;59(3):462-474. doi: 10.1194/jlr.M081307. Epub 2018 Jan 11. PubMed
ARID5B as a critical downstream target of the TAL1 complex that activates the oncogenic transcriptional program and promotes T-cell leukemogenesis. Leong WZ, Tan SH, Ngoc PCT, Amanda S, Yam AWY, Liau WS, Gong Z, Lawton LN, Tenen DG, Sanda T. Genes Dev. 2017 Dec 1;31(23-24):2343-2360. doi: 10.1101/gad.302646.117. Epub 2018 Jan 11. PubMed
Foxo-dependent Par-4 Upregulation Prevents Long-term Survival of Residual Cells Following PI3K-Akt Inhibition. Damrauer JS, Phelps SN, Amuchastegui K, Lupo R, Mabe NW, Walens A, Kroger BR, Alvarez JV. Mol Cancer Res. 2018 Apr;16(4):599-609. doi: 10.1158/1541-7786.MCR-17-0492. Epub 2018 Jan 12. PubMed
BRCA1 through Its E3 Ligase Activity Regulates the Transcription Factor Oct1 and Carbohydrate Metabolism. Vazquez-Arreguin K, Maddox J, Kang J, Park D, Cano RR, Factor RE, Ludwig T, Tantin D. Mol Cancer Res. 2018 Mar;16(3):439-452. doi: 10.1158/1541-7786.MCR-17-0364. Epub 2018 Jan 12. PubMed
As Extracellular Glutamine Levels Decline, Asparagine Becomes an Essential Amino Acid. Pavlova NN, Hui S, Ghergurovich JM, Fan J, Intlekofer AM, White RM, Rabinowitz JD, Thompson CB, Zhang J. Cell Metab. 2018 Feb 6;27(2):428-438.e5. doi: 10.1016/j.cmet.2017.12.006. Epub 2018 Jan 11. PubMed
PD-L1 on host cells is essential for PD-L1 blockade-mediated tumor regression. Tang H, Liang Y, Anders RA, Taube JM, Qiu X, Mulgaonkar A, Liu X, Harrington SM, Guo J, Xin Y, Xiong Y, Nham K, Silvers W, Hao G, Sun X, Chen M, Hannan R, Qiao J, Dong H, Peng H, Fu YX. J Clin Invest. 2018 Feb 1;128(2):580-588. doi: 10.1172/JCI96061. Epub 2018 Jan 16. PubMed
Histone Variant MacroH2A1 Plays an Isoform-Specific Role in Suppressing Epithelial-Mesenchymal Transition. Hodge DQ, Cui J, Gamble MJ, Guo W. Sci Rep. 2018 Jan 16;8(1):841. doi: 10.1038/s41598-018-19364-4. PubMed
CYR61/CCN1 Regulates Sclerostin Levels and Bone Maintenance. Zhao G, Huang BL, Rigueur D, Wang W, Bhoot C, Charles KR, Baek J, Mohan S, Jiang J, Lyons KM. J Bone Miner Res. 2018 Jun;33(6):1076-1089. doi: 10.1002/jbmr.3394. Epub 2018 Mar 5. PubMed
A Distinct Class of Genome Rearrangements Driven by Heterologous Recombination. Leon-Ortiz AM, Panier S, Sarek G, Vannier JB, Patel H, Campbell PJ, Boulton SJ. Mol Cell. 2018 Jan 18;69(2):292-305.e6. doi: 10.1016/j.molcel.2017.12.014. PubMed
Interferon regulatory factor 8 regulates caspase-1 expression to facilitate Epstein-Barr virus reactivation in response to B cell receptor stimulation and chemical induction. Lv DW, Zhang K, Li R. PLoS Pathog. 2018 Jan 22;14(1):e1006868. doi: 10.1371/journal.ppat.1006868. eCollection 2018 Jan. PubMed
Large-scale image-based profiling of single-cell phenotypes in arrayed CRISPR-Cas9 gene perturbation screens. de Groot R, Luthi J, Lindsay H, Holtackers R, Pelkmans L. Mol Syst Biol. 2018 Jan 23;14(1):e8064. doi: 10.15252/msb.20178064. PubMed
IKKbeta is a beta-catenin kinase that regulates mesenchymal stem cell differentiation. Sui Y, Liu Z, Park SH, Thatcher SE, Zhu B, Fernandez JP, Molina H, Kern PA, Zhou C. JCI Insight. 2018 Jan 25;3(2). pii: 96660. doi: 10.1172/jci.insight.96660. eCollection 2018 Jan 25. PubMed
A positive feedback loop between IL-1beta, LPS and NEU1 may promote atherosclerosis by enhancing a pro-inflammatory state in monocytes and macrophages. Sieve I, Ricke-Hoch M, Kasten M, Battmer K, Stapel B, Falk CS, Leisegang MS, Haverich A, Scherr M, Hilfiker-Kleiner D. Vascul Pharmacol. 2018 Apr;103-105:16-28. doi: 10.1016/j.vph.2018.01.005. Epub 2018 Jan 31. PubMed
Editing of the human TRIM5 gene to introduce mutations with the potential to inhibit HIV-1. Dufour C, Claudel A, Joubarne N, Merindol N, Maisonnet T, Masroori N, Plourde MB, Berthoux L. PLoS One. 2018 Jan 26;13(1):e0191709. doi: 10.1371/journal.pone.0191709. eCollection 2018. PubMed
Glioma tumor suppressor candidate region gene 1 (GLTSCR1) and its paralog GLTSCR1-like form SWI/SNF chromatin remodeling subcomplexes. Alpsoy A, Dykhuizen EC. J Biol Chem. 2018 Jan 26. pii: RA117.001065. doi: 10.1074/jbc.RA117.001065. PubMed
The non-classical nuclear import carrier Transportin 1 modulates circadian rhythms through its effect on PER1 nuclear localization. Korge S, Maier B, Bruning F, Ehrhardt L, Korte T, Mann M, Herrmann A, Robles MS, Kramer A. PLoS Genet. 2018 Jan 29;14(1):e1007189. doi: 10.1371/journal.pgen.1007189. eCollection 2018 Jan. PubMed
AXL promotes Zika virus infection in astrocytes by antagonizing type I interferon signalling. Chen J, Yang YF, Yang Y, Zou P, Chen J, He Y, Shui SL, Cui YR, Bai R, Liang YJ, Hu Y, Jiang B, Lu L, Zhang X, Liu J, Xu J. Nat Microbiol. 2018 Mar;3(3):302-309. doi: 10.1038/s41564-017-0092-4. Epub 2018 Jan 29. PubMed
Discovery of Potent and Selective MRCK Inhibitors with Therapeutic Effect on Skin Cancer. Unbekandt M, Belshaw S, Bower J, Clarke M, Cordes J, Crighton D, Croft DR, Drysdale MJ, Garnett MJ, Gill K, Gray C, Greenhalgh DA, Hall JAM, Konczal J, Lilla S, McArthur D, McConnell P, McDonald L, McGarry L, McKinnon H, McMenemy C, Mezna M, Morrice NA, Munro J, Naylor G, Rath N, Schuttelkopf AW, Sime M, Olson MF. Cancer Res. 2018 Apr 15;78(8):2096-2114. doi: 10.1158/0008-5472.CAN-17-2870. Epub 2018 Jan 30. PubMed
Mucolipin-2 Cation Channel Increases Trafficking Efficiency of Endocytosed Viruses. Rinkenberger N, Schoggins JW. MBio. 2018 Jan 30;9(1). pii: mBio.02314-17. doi: 10.1128/mBio.02314-17. PubMed
Altering lipid droplet homeostasis affects Coxiella burnetii intracellular growth. Mulye M, Zapata B, Gilk SD. PLoS One. 2018 Feb 1;13(2):e0192215. doi: 10.1371/journal.pone.0192215. eCollection 2018. PubMed
Desensitized chimeric antigen receptor T cells selectively recognize target cells with enhanced antigen expression. Han C, Sim SJ, Kim SH, Singh R, Hwang S, Kim YI, Park SH, Kim KH, Lee DG, Oh HS, Lee S, Kim YH, Choi BK, Kwon BS. Nat Commun. 2018 Feb 1;9(1):468. doi: 10.1038/s41467-018-02912-x. PubMed
TRPC3 is required for the survival, pluripotency and neural differentiation of mouse embryonic stem cells (mESCs). Hao HB, Webb SE, Yue J, Moreau M, Leclerc C, Miller AL. Sci China Life Sci. 2018 Mar;61(3):253-265. doi: 10.1007/s11427-017-9222-9. Epub 2018 Jan 31. PubMed
Integrin CD11b negatively regulates Mincle-induced signaling via the Lyn-SIRPalpha-SHP1 complex. Zhang Q, Lee WB, Kang JS, Kim LK, Kim YJ. Exp Mol Med. 2018 Feb 5;50(2):e439. doi: 10.1038/emm.2017.256. PubMed
CRISPR interference-based specific and efficient gene inactivation in the brain. Zheng Y, Shen W, Zhang J, Yang B, Liu YN, Qi H, Yu X, Lu SY, Chen Y, Xu YZ, Li Y, Gage FH, Mi S, Yao J. Nat Neurosci. 2018 Mar;21(3):447-454. doi: 10.1038/s41593-018-0077-5. Epub 2018 Feb 5. PubMed
Long noncoding RNA PANDAR blocks CDKN1A gene transcription by competitive interaction with p53 protein in gastric cancer. Liu J, Ben Q, Lu E, He X, Yang X, Ma J, Zhang W, Wang Z, Liu T, Zhang J, Wang H. Cell Death Dis. 2018 Feb 7;9(2):168. doi: 10.1038/s41419-017-0246-6. PubMed
Primary Airway Epithelial Cell Gene Editing Using CRISPR-Cas9. Everman JL, Rios C, Seibold MA. Methods Mol Biol. 2018;1706:267-292. doi: 10.1007/978-1-4939-7471-9_15. PubMed
Secreted AGR2 promotes invasion of colorectal cancer cells via Wnt11-mediated non-canonical Wnt signaling. Tian S, Hu J, Tao K, Wang J, Chu Y, Li J, Liu Z, Ding X, Xu L, Li Q, Cai M, Gao J, Shuai X, Wang G, Wang L, Wang Z. Exp Cell Res. 2018 Mar 15;364(2):198-207. doi: 10.1016/j.yexcr.2018.02.004. Epub 2018 Feb 7. PubMed
Differential Delivery of Genomic Double-Stranded RNA Causes Reovirus Strain-Specific Differences in Interferon Regulatory Factor 3 Activation. Stuart JD, Holm GH, Boehme KW. J Virol. 2018 Apr 13;92(9). pii: JVI.01947-17. doi: 10.1128/JVI.01947-17. Print 2018 May 1. PubMed
MYL6B, a myosin light chain, promotes MDM2-mediated p53 degradation and drives HCC development. Xie X, Wang X, Liao W, Fei R, Wu N, Cong X, Chen Q, Wei L, Wang Y, Chen H. J Exp Clin Cancer Res. 2018 Feb 13;37(1):28. doi: 10.1186/s13046-018-0693-7. PubMed
A Human Genome-Wide RNAi Screen Reveals Diverse Modulators that Mediate IRE1alpha-XBP1 Activation. Yang Z, Zhang J, Jiang D, Khatri P, Solow-Cordero DE, Toesca DAS, Koumenis C, Denko NC, Giaccia AJ, Le QT, Koong AC. Mol Cancer Res. 2018 May;16(5):745-753. doi: 10.1158/1541-7786.MCR-17-0307. Epub 2018 Feb 9. PubMed
SLAMF1 is required for TLR4-mediated TRAM-TRIF-dependent signaling in human macrophages. Yurchenko M, Skjesol A, Ryan L, Richard GM, Kandasamy RK, Wang N, Terhorst C, Husebye H, Espevik T. J Cell Biol. 2018 Apr 2;217(4):1411-1429. doi: 10.1083/jcb.201707027. Epub 2018 Feb 12. PubMed
Kinesin 1 regulates cilia length through an interaction with the Bardet-Biedl syndrome related protein CCDC28B. Novas R, Cardenas-Rodriguez M, Lepanto P, Fabregat M, Rodao M, Fariello MI, Ramos M, Davison C, Casanova G, Alfaya L, Lecumberry F, Gonzalez-Sapienza G, Irigoin F, Badano JL. Sci Rep. 2018 Feb 14;8(1):3019. doi: 10.1038/s41598-018-21329-6. PubMed
Dynamic network biomarker indicates pulmonary metastasis at the tipping point of hepatocellular carcinoma. Yang B, Li M, Tang W, Liu W, Zhang S, Chen L, Xia J. Nat Commun. 2018 Feb 14;9(1):678. doi: 10.1038/s41467-018-03024-2. PubMed
A paralogous pair of mammalian host restriction factors form a critical host barrier against poxvirus infection. Meng X, Zhang F, Yan B, Si C, Honda H, Nagamachi A, Sun LZ, Xiang Y. PLoS Pathog. 2018 Feb 15;14(2):e1006884. doi: 10.1371/journal.ppat.1006884. eCollection 2018 Feb. PubMed
Hypothalamic ER-associated degradation regulates POMC maturation, feeding, and age-associated obesity. Kim GH, Shi G, Somlo DR, Haataja L, Song S, Long Q, Nillni EA, Low MJ, Arvan P, Myers MG Jr, Qi L. J Clin Invest. 2018 Mar 1;128(3):1125-1140. doi: 10.1172/JCI96420. Epub 2018 Feb 19. PubMed
Cooperative p16 and p21 action protects female astrocytes from transformation. Kfoury N, Sun T, Yu K, Rockwell N, Tinkum KL, Qi Z, Warrington NM, McDonald P, Roy A, Weir SJ, Mohila CA, Deneen B, Rubin JB. Acta Neuropathol Commun. 2018 Feb 20;6(1):12. doi: 10.1186/s40478-018-0513-5. PubMed
Inhibition of autophagy sensitizes cancer cells to Photofrin-based photodynamic therapy. Domagala A, Stachura J, Gabrysiak M, Muchowicz A, Zagozdzon R, Golab J, Firczuk M. BMC Cancer. 2018 Feb 20;18(1):210. doi: 10.1186/s12885-018-4126-y. PubMed
Clonal dynamics towards the development of venetoclax resistance in chronic lymphocytic leukemia. Herling CD, Abedpour N, Weiss J, Schmitt A, Jachimowicz RD, Merkel O, Cartolano M, Oberbeck S, Mayer P, Berg V, Thomalla D, Kutsch N, Stiefelhagen M, Cramer P, Wendtner CM, Persigehl T, Saleh A, Altmuller J, Nurnberg P, Pallasch C, Achter V, Lang U, Eichhorst B, Castiglione R, Schafer SC, Buttner R, Kreuzer KA, Reinhardt HC, Hallek M, Frenzel LP, Peifer M. Nat Commun. 2018 Feb 20;9(1):727. doi: 10.1038/s41467-018-03170-7. PubMed
A translational silencing function of MCPIP1/Regnase-1 specified by the target site context. Behrens G, Winzen R, Rehage N, Dorrie A, Barsch M, Hoffmann A, Hackermuller J, Tiedje C, Heissmeyer V, Holtmann H. Nucleic Acids Res. 2018 May 4;46(8):4256-4270. doi: 10.1093/nar/gky106. PubMed
Knockdown of Human AMPK Using the CRISPR/Cas9 Genome-Editing System. Grenier A, Sujobert P, Olivier S, Guermouche H, Mondesir J, Kosmider O, Viollet B, Tamburini J. Methods Mol Biol. 2018;1732:171-194. doi: 10.1007/978-1-4939-7598-3_11. PubMed
Attenuation of cGAS-STING signaling is mediated by a p62/SQSTM1-dependent autophagy pathway activated by TBK1. Prabakaran T, Bodda C, Krapp C, Zhang BC, Christensen MH, Sun C, Reinert L, Cai Y, Jensen SB, Skouboe MK, Nyengaard JR, Thompson CB, Lebbink RJ, Sen GC, van Loo G, Nielsen R, Komatsu M, Nejsum LN, Jakobsen MR, Gyrd-Hansen M, Paludan SR. EMBO J. 2018 Apr 13;37(8). pii: embj.201797858. doi: 10.15252/embj.201797858. Epub 2018 Mar 1. PubMed
PARP14 Controls the Nuclear Accumulation of a Subset of Type I IFN-Inducible Proteins. Caprara G, Prosperini E, Piccolo V, Sigismondo G, Melacarne A, Cuomo A, Boothby M, Rescigno M, Bonaldi T, Natoli G. J Immunol. 2018 Apr 1;200(7):2439-2454. doi: 10.4049/jimmunol.1701117. Epub 2018 Mar 2. PubMed
Novel RNA-Affinity Proteogenomics Dissects Tumor Heterogeneity for Revealing Personalized Markers in Precision Prognosis of Cancer. Wang L, Wrobel JA, Xie L, Li D, Zurlo G, Shen H, Yang P, Wang Z, Peng Y, Gunawardena HP, Zhang Q, Chen X. Cell Chem Biol. 2018 May 17;25(5):619-633.e5. doi: 10.1016/j.chembiol.2018.01.016. Epub 2018 Mar 1. PubMed
Robust DNA repair in PAXX-deficient mammalian cells. Dewan A, Xing M, Lundbaek MB, Gago-Fuentes R, Beck C, Aas PA, Liabakk NB, Saeterstad S, Chau KTP, Kavli BM, Oksenych V. FEBS Open Bio. 2018 Feb 7;8(3):442-448. doi: 10.1002/2211-5463.12380. eCollection 2018 Mar. PubMed
Site-specific glycosylation regulates the form and function of the intermediate filament cytoskeleton. Tarbet HJ, Dolat L, Smith TJ, Condon BM, O'Brien ET 3rd, Valdivia RH, Boyce M. Elife. 2018 Mar 7;7. pii: 31807. doi: 10.7554/eLife.31807. PubMed
Porcine MKRN1 Modulates the Replication and Pathogenesis of Porcine Circovirus Type 2 by Inducing Capsid Protein Ubiquitination and Degradation. Wang T, Du Q, Wu X, Niu Y, Guan L, Wang Z, Zhao X, Liu SL, Tong D, Huang Y. J Virol. 2018 May 14;92(11). pii: JVI.00100-18. doi: 10.1128/JVI.00100-18. Print 2018 Jun 1. PubMed
The convergent roles of NF-kappaB and ER stress in sunitinib-mediated expression of pro-tumorigenic cytokines and refractory phenotype in renal cell carcinoma. Makhov P, Naito S, Haifler M, Kutikov A, Boumber Y, Uzzo RG, Kolenko VM. Cell Death Dis. 2018 Mar 7;9(3):374. doi: 10.1038/s41419-018-0388-1. PubMed
Caspase-3 regulates the migration, invasion and metastasis of colon cancer cells. Zhou M, Liu X, Li Z, Huang Q, Li F, Li CY. Int J Cancer. 2018 Aug 15;143(4):921-930. doi: 10.1002/ijc.31374. Epub 2018 Mar 30. PubMed
Human IFIT3 Modulates IFIT1 RNA Binding Specificity and Protein Stability. Johnson B, VanBlargan LA, Xu W, White JP, Shan C, Shi PY, Zhang R, Adhikari J, Gross ML, Leung DW, Diamond MS, Amarasinghe GK. Immunity. 2018 Mar 20;48(3):487-499.e5. doi: 10.1016/j.immuni.2018.01.014. Epub 2018 Mar 8. PubMed
Insulin resistance causes inflammation in adipose tissue. Shimobayashi M, Albert V, Woelnerhanssen B, Frei IC, Weissenberger D, Meyer-Gerspach AC, Clement N, Moes S, Colombi M, Meier JA, Swierczynska MM, Jeno P, Beglinger C, Peterli R, Hall MN. J Clin Invest. 2018 Apr 2;128(4):1538-1550. doi: 10.1172/JCI96139. Epub 2018 Mar 12. PubMed
NuRD and CAF-1-mediated silencing of the D4Z4 array is modulated by DUX4-induced MBD3L proteins. Campbell AE, Shadle SC, Jagannathan S, Lim JW, Resnick R, Tawil R, van der Maarel SM, Tapscott SJ. Elife. 2018 Mar 13;7. pii: 31023. doi: 10.7554/eLife.31023. PubMed

Associated Plasmids

Intraflagellar transport is deeply integrated in hedgehog signaling. Eguether T, Cordelieres FP, Pazour GJ. Mol Biol Cell. 2018 May 15;29(10):1178-1189. doi: 10.1091/mbc.E17-10-0600. Epub 2018 Mar 22. PubMed
Reshaping of the Dendritic Cell Chromatin Landscape and Interferon Pathways during HIV Infection. Johnson JS, Lucas SY, Amon LM, Skelton S, Nazitto R, Carbonetti S, Sather DN, Littman DR, Aderem A. Cell Host Microbe. 2018 Mar 14;23(3):366-381.e9. doi: 10.1016/j.chom.2018.01.012. PubMed
PI3K Positively Regulates YAP and TAZ in Mammary Tumorigenesis Through Multiple Signaling Pathways. Zhao Y, Montminy T, Azad T, Lightbody E, Hao Y, SenGupta S, Asselin E, Nicol C, Yang X. Mol Cancer Res. 2018 Jun;16(6):1046-1058. doi: 10.1158/1541-7786.MCR-17-0593. Epub 2018 Mar 15. PubMed
Coordinated Activity of Y Family TLS Polymerases and EXO1 Protects Non-S Phase Cells from UV-Induced Cytotoxic Lesions. Sertic S, Mollica A, Campus I, Roma S, Tumini E, Aguilera A, Muzi-Falconi M. Mol Cell. 2018 Apr 5;70(1):34-47.e4. doi: 10.1016/j.molcel.2018.02.017. Epub 2018 Mar 15. PubMed

Associated Plasmids

Thyroid transcription factor 1 enhances cellular statin sensitivity via perturbing cholesterol metabolism. Lai SC, Phelps CA, Short AM, Dutta SM, Mu D. Oncogene. 2018 Mar 19. pii: 10.1038/s41388-018-0174-7. doi: 10.1038/s41388-018-0174-7. PubMed

Associated Plasmids

A CRISPR screen for factors regulating SAMHD1 degradation identifies IFITMs as potent inhibitors of lentiviral particle delivery. Roesch F, OhAinle M, Emerman M. Retrovirology. 2018 Mar 20;15(1):26. doi: 10.1186/s12977-018-0409-2. PubMed
Detection of aryl hydrocarbon receptor agonists in human samples. Rothhammer V, Borucki DM, Kenison JE, Hewson P, Wang Z, Bakshi R, Sherr DH, Quintana FJ. Sci Rep. 2018 Mar 21;8(1):4970. doi: 10.1038/s41598-018-23323-4. PubMed
Notch and Aryl Hydrocarbon Receptor Signaling Impact Definitive Hematopoiesis from Human Pluripotent Stem Cells. Leung A, Zulick E, Skvir N, Vanuytsel K, Morrison TA, Naing ZH, Wang Z, Dai Y, Chui DHK, Steinberg MH, Sherr DH, Murphy GJ. Stem Cells. 2018 Jul;36(7):1004-1019. doi: 10.1002/stem.2822. Epub 2018 Apr 1. PubMed
Dnmt3a in the dorsal dentate gyrus is a key regulator of fear renewal. Gong Z, Zhou Q. Sci Rep. 2018 Mar 23;8(1):5093. doi: 10.1038/s41598-018-23533-w. PubMed
Profound Tissue Specificity in Proliferation Control Underlies Cancer Drivers and Aneuploidy Patterns. Sack LM, Davoli T, Li MZ, Li Y, Xu Q, Naxerova K, Wooten EC, Bernardi RJ, Martin TD, Chen T, Leng Y, Liang AC, Scorsone KA, Westbrook TF, Wong KK, Elledge SJ. Cell. 2018 Apr 5;173(2):499-514.e23. doi: 10.1016/j.cell.2018.02.037. Epub 2018 Mar 22. PubMed
L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage. Nowsheen S, Aziz K, Aziz A, Deng M, Qin B, Luo K, Jeganathan KB, Zhang H, Liu T, Yu J, Deng Y, Yuan J, Ding W, van Deursen JM, Lou Z. Nat Cell Biol. 2018 Apr;20(4):455-464. doi: 10.1038/s41556-018-0071-x. Epub 2018 Mar 26. PubMed
Use of Organoids to Characterize Signaling Pathways in Cancer Initiation. Oatway C, Hirsch CL, Gregorieff A. Methods Mol Biol. 2018;1765:315-331. doi: 10.1007/978-1-4939-7765-9_21. PubMed
A multiplatform approach identifies miR-152-3p as a common epigenetically regulated onco-suppressor in prostate cancer targeting TMEM97. Ramalho-Carvalho J, Goncalves CS, Graca I, Bidarra D, Pereira-Silva E, Salta S, Godinho MI, Gomez A, Esteller M, Costa BM, Henrique R, Jeronimo C. Clin Epigenetics. 2018 Mar 27;10:40. doi: 10.1186/s13148-018-0475-2. eCollection 2018. PubMed
Impact of Nrf2 on tumour growth and drug sensitivity in oncogenic K-ras-transformed cells in vitro and in vivo. Shao J, Glorieux C, Liao J, Chen P, Lu W, Liang Z, Wen S, Hu Y, Huang P. Free Radic Res. 2018 Jun;52(6):661-671. doi: 10.1080/10715762.2018.1462494. Epub 2018 May 3. PubMed
Genome scale screening identification of SaCas9/gRNAs for targeting HIV-1 provirus and suppression of HIV-1 infection. Wang Q, Liu S, Liu Z, Ke Z, Li C, Yu X, Chen S, Guo D. Virus Res. 2018 May 2;250:21-30. doi: 10.1016/j.virusres.2018.04.002. Epub 2018 Apr 3. PubMed
Pseudouridylation of tRNA-Derived Fragments Steers Translational Control in Stem Cells. Guzzi N, Ciesla M, Ngoc PCT, Lang S, Arora S, Dimitriou M, Pimkova K, Sommarin MNE, Munita R, Lubas M, Lim Y, Okuyama K, Soneji S, Karlsson G, Hansson J, Jonsson G, Lund AH, Sigvardsson M, Hellstrom-Lindberg E, Hsieh AC, Bellodi C. Cell. 2018 May 17;173(5):1204-1216.e26. doi: 10.1016/j.cell.2018.03.008. Epub 2018 Apr 5. PubMed
A novel neuregulin - jagged1 paracrine loop in breast cancer transendothelial migration. Cabrera RM, Mao SPH, Surve CR, Condeelis JS, Segall JE. Breast Cancer Res. 2018 Apr 10;20(1):24. doi: 10.1186/s13058-018-0960-8. PubMed
Single HIV-1 Imaging Reveals Progression of Infection through CA-Dependent Steps of Docking at the Nuclear Pore, Uncoating, and Nuclear Transport. Francis AC, Melikyan GB. Cell Host Microbe. 2018 Apr 11;23(4):536-548.e6. doi: 10.1016/j.chom.2018.03.009. PubMed
Nrf2 signaling and autophagy are complementary in protecting breast cancer cells during glucose deprivation. Walker A, Singh A, Tully E, Woo J, Le A, Nguyen T, Biswal S, Sharma D, Gabrielson E. Free Radic Biol Med. 2018 May 20;120:407-413. doi: 10.1016/j.freeradbiomed.2018.04.009. Epub 2018 Apr 9. PubMed
ERF deletion rescues RAS deficiency in mouse embryonic stem cells. Mayor-Ruiz C, Olbrich T, Drosten M, Lecona E, Vega-Sendino M, Ortega S, Dominguez O, Barbacid M, Ruiz S, Fernandez-Capetillo O. Genes Dev. 2018 Apr 1;32(7-8):568-576. doi: 10.1101/gad.310086.117. Epub 2018 Apr 12. PubMed
Nucleic acid-induced potentiation of matrix metalloproteinase-9 enzymatic activity. Duellman T, Chen X, Wakamiya R, Yang J. Biochem J. 2018 May 9;475(9):1597-1610. doi: 10.1042/BCJ20180035. PubMed
GCN2 deficiency ameliorates doxorubicin-induced cardiotoxicity by decreasing cardiomyocyte apoptosis and myocardial oxidative stress. Wang Y, Lei T, Yuan J, Wu Y, Shen X, Gao J, Feng W, Lu Z. Redox Biol. 2018 Jul;17:25-34. doi: 10.1016/j.redox.2018.04.009. Epub 2018 Apr 7. PubMed
STAG2 deficiency induces interferon responses via cGAS-STING pathway and restricts virus infection. Ding S, Diep J, Feng N, Ren L, Li B, Ooi YS, Wang X, Brulois KF, Yasukawa LL, Li X, Kuo CJ, Solomon DA, Carette JE, Greenberg HB. Nat Commun. 2018 Apr 16;9(1):1485. doi: 10.1038/s41467-018-03782-z. PubMed
USP9X Limits Mitotic Checkpoint Complex Turnover to Strengthen the Spindle Assembly Checkpoint and Guard against Chromosomal Instability. Skowyra A, Allan LA, Saurin AT, Clarke PR. Cell Rep. 2018 Apr 17;23(3):852-865. doi: 10.1016/j.celrep.2018.03.100. PubMed
Methylation-induced silencing of SPG20 facilitates gastric cancer cell proliferation by activating the EGFR/MAPK pathway. Zhou Z, Wang W, Xie X, Song Y, Dang C, Zhang H. Biochem Biophys Res Commun. 2018 Jun 2;500(2):411-417. doi: 10.1016/j.bbrc.2018.04.089. Epub 2018 Apr 18. PubMed
KREMEN1 Is a Host Entry Receptor for a Major Group of Enteroviruses. Staring J, van den Hengel LG, Raaben M, Blomen VA, Carette JE, Brummelkamp TR. Cell Host Microbe. 2018 May 9;23(5):636-643.e5. doi: 10.1016/j.chom.2018.03.019. Epub 2018 Apr 19. PubMed
Requirement of GSK-3 for PUMA induction upon loss of pro-survival PI3K signaling. Schubert F, Rapp J, Brauns-Schubert P, Schlicher L, Stock K, Wissler M, Weiss M, Charvet C, Borner C, Maurer U. Cell Death Dis. 2018 May 1;9(5):470. doi: 10.1038/s41419-018-0502-4. PubMed
The multiple myeloma risk allele at 5q15 lowers ELL2 expression and increases ribosomal gene expression. Ali M, Ajore R, Wihlborg AK, Niroula A, Swaminathan B, Johnsson E, Stephens OW, Morgan G, Meissner T, Turesson I, Goldschmidt H, Mellqvist UH, Gullberg U, Hansson M, Hemminki K, Nahi H, Waage A, Weinhold N, Nilsson B. Nat Commun. 2018 Apr 25;9(1):1649. doi: 10.1038/s41467-018-04082-2. PubMed
The GABAA Receptor beta Subunit Is Required for Inhibitory Transmission. Nguyen QA, Nicoll RA. Neuron. 2018 May 16;98(4):718-725.e3. doi: 10.1016/j.neuron.2018.03.046. Epub 2018 Apr 26. PubMed
MicroRNA-focused CRISPR-Cas9 Library Screen Reveals Fitness-Associated miRNAs. Kurata JS, Lin RJ. RNA. 2018 May 2. pii: rna.066282.118. doi: 10.1261/rna.066282.118. PubMed

Associated Plasmids

Imaging, myeloid precursor immortalization, and genome editing for defining mechanisms of leukocyte recruitment in vivo. Gran S, Honold L, Fehler O, Zenker S, Eligehausen S, Kuhlmann MT, Geven E, van den Bosch M, van Lent P, Spiekermann C, Hermann S, Vogl T, Schafers M, Roth J. Theranostics. 2018 Mar 23;8(9):2407-2423. doi: 10.7150/thno.23632. eCollection 2018. PubMed
Complimentary mechanisms of dual checkpoint blockade expand unique T-cell repertoires and activate adaptive anti-tumor immunity in triple-negative breast tumors. Crosby EJ, Wei J, Yang XY, Lei G, Wang T, Liu CX, Agarwal P, Korman AJ, Morse MA, Gouin K, Knott SRV, Lyerly HK, Hartman ZC. Oncoimmunology. 2018 Jan 19;7(5):e1421891. doi: 10.1080/2162402X.2017.1421891. eCollection 2018. PubMed
Myeloid beta-Catenin Deficiency Exacerbates Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient Mice. Wang F, Liu Z, Park SH, Gwag T, Lu W, Ma M, Sui Y, Zhou C. Arterioscler Thromb Vasc Biol. 2018 Jul;38(7):1468-1478. doi: 10.1161/ATVBAHA.118.311059. Epub 2018 May 3. PubMed
Towards Resolving the Pro- and Anti-Tumor Effects of the Aryl Hydrocarbon Receptor. Narasimhan S, Stanford Zulick E, Novikov O, Parks AJ, Schlezinger JJ, Wang Z, Laroche F, Feng H, Mulas F, Monti S, Sherr DH. Int J Mol Sci. 2018 May 7;19(5). pii: ijms19051388. doi: 10.3390/ijms19051388. PubMed
Essential Role of Linx/Islr2 in the Development of the Forebrain Anterior Commissure. Abudureyimu S, Asai N, Enomoto A, Weng L, Kobayashi H, Wang X, Chen C, Mii S, Takahashi M. Sci Rep. 2018 May 8;8(1):7292. doi: 10.1038/s41598-018-24064-0. PubMed
TGF-beta induces miR-100 and miR-125b but blocks let-7a through LIN28B controlling PDAC progression. Ottaviani S, Stebbing J, Frampton AE, Zagorac S, Krell J, de Giorgio A, Trabulo SM, Nguyen VTM, Magnani L, Feng H, Giovannetti E, Funel N, Gress TM, Jiao LR, Lombardo Y, Lemoine NR, Heeschen C, Castellano L. Nat Commun. 2018 May 10;9(1):1845. doi: 10.1038/s41467-018-03962-x. PubMed
Arginase 2 Suppresses Renal Carcinoma Progression via Biosynthetic Cofactor Pyridoxal Phosphate Depletion and Increased Polyamine Toxicity. Ochocki JD, Khare S, Hess M, Ackerman D, Qiu B, Daisak JI, Worth AJ, Lin N, Lee P, Xie H, Li B, Wubbenhorst B, Maguire TG, Nathanson KL, Alwine JC, Blair IA, Nissim I, Keith B, Simon MC. Cell Metab. 2018 Jun 5;27(6):1263-1280.e6. doi: 10.1016/j.cmet.2018.04.009. Epub 2018 May 10. PubMed
Mxra8 is a receptor for multiple arthritogenic alphaviruses. Zhang R, Kim AS, Fox JM, Nair S, Basore K, Klimstra WB, Rimkunas R, Fong RH, Lin H, Poddar S, Crowe JE Jr, Doranz BJ, Fremont DH, Diamond MS. Nature. 2018 May;557(7706):570-574. doi: 10.1038/s41586-018-0121-3. Epub 2018 May 16. PubMed
CRISPR/Cas9 system targeting regulatory genes of HIV-1 inhibits viral replication in infected T-cell cultures. Ophinni Y, Inoue M, Kotaki T, Kameoka M. Sci Rep. 2018 May 17;8(1):7784. doi: 10.1038/s41598-018-26190-1. PubMed
Transactivation domain of p53 regulates DNA repair and integrity in human iPS cells. Kannappan R, Mattapally S, Wagle PA, Zhang J. Am J Physiol Heart Circ Physiol. 2018 Sep 1;315(3):H512-H521. doi: 10.1152/ajpheart.00160.2018. Epub 2018 May 18. PubMed
The Bicarbonate Transporter SLC4A7 Plays a Key Role in Macrophage Phagosome Acidification. Sedlyarov V, Eichner R, Girardi E, Essletzbichler P, Goldmann U, Nunes-Hasler P, Srndic I, Moskovskich A, Heinz LX, Kartnig F, Bigenzahn JW, Rebsamen M, Kovarik P, Demaurex N, Superti-Furga G. Cell Host Microbe. 2018 Jun 13;23(6):766-774.e5. doi: 10.1016/j.chom.2018.04.013. Epub 2018 May 17. PubMed
The Eukaryotic Proteome Is Shaped by E3 Ubiquitin Ligases Targeting C-Terminal Degrons. Koren I, Timms RT, Kula T, Xu Q, Li MZ, Elledge SJ. Cell. 2018 Jun 14;173(7):1622-1635.e14. doi: 10.1016/j.cell.2018.04.028. Epub 2018 May 17. PubMed
TANK-binding kinase 1 and Janus kinase 2 play important roles in the regulation of mitogen-activated protein kinase phosphatase-1 expression after toll-like receptor 4 activation. Kim E, Yoon JY, Lee J, Jeong D, Park JG, Hong YH, Kim JH, Aravinthan A, Kim JH, Cho JY. J Cell Physiol. 2018 Nov;233(11):8790-8801. doi: 10.1002/jcp.26787. Epub 2018 May 24. PubMed
Partial Inactivation of the Chromatin Remodelers SMARCA2 and SMARCA4 in Virus-Infected Cells by Caspase-Mediated Cleavage. Dudek AH, Pfaff F, Bolte H, Waguia Kontchou C, Schwemmle M. J Virol. 2018 Jul 31;92(16). pii: JVI.00343-18. doi: 10.1128/JVI.00343-18. Print 2018 Aug 15. PubMed
CRISPR/Cas9 Genome Editing of Epidermal Growth Factor Receptor Sufficiently Abolished Oncogenicity in Anaplastic Thyroid Cancer. Huang LC, Tam KW, Liu WN, Lin CY, Hsu KW, Hsieh WS, Chi WM, Lee AW, Yang JM, Lin CL, Lee CH. Dis Markers. 2018 Apr 12;2018:3835783. doi: 10.1155/2018/3835783. eCollection 2018. PubMed
Inhibition of Wnt/beta-catenin signaling downregulates expression of aldehyde dehydrogenase isoform 3A1 (ALDH3A1) to reduce resistance against temozolomide in glioblastoma in vitro. Suwala AK, Koch K, Rios DH, Aretz P, Uhlmann C, Ogorek I, Felsberg J, Reifenberger G, Kohrer K, Deenen R, Steiger HJ, Kahlert UD, Maciaczyk J. Oncotarget. 2018 Apr 27;9(32):22703-22716. doi: 10.18632/oncotarget.25210. eCollection 2018 Apr 27. PubMed
Inhibition of the ER stress IRE1alpha inflammatory pathway protects against cell death in mitochondrial complex I mutant cells. Soustek MS, Balsa E, Barrow JJ, Jedrychowski M, Vogel R, Jan Smeitink, Gygi SP, Puigserver P. Cell Death Dis. 2018 May 31;9(6):658. doi: 10.1038/s41419-018-0696-5. PubMed
Methylation of hypoxia-inducible factor (HIF)-1alpha by G9a/GLP inhibits HIF-1 transcriptional activity and cell migration. Bao L, Chen Y, Lai HT, Wu SY, Wang JE, Hatanpaa KJ, Raisanen JM, Fontenot M, Lega B, Chiang CM, Semenza GL, Wang Y, Luo W. Nucleic Acids Res. 2018 Jul 27;46(13):6576-6591. doi: 10.1093/nar/gky449. PubMed
Myopia-Inhibiting Concentrations of Muscarinic Receptor Antagonists Block Activation of Alpha2A-Adrenoceptors In Vitro. Carr BJ, Mihara K, Ramachandran R, Saifeddine M, Nathanson NM, Stell WK, Hollenberg MD. Invest Ophthalmol Vis Sci. 2018 Jun 1;59(7):2778-2791. doi: 10.1167/iovs.17-22562. PubMed
Renal immune surveillance and dipeptidase-1 contribute to contrast-induced acute kidney injury. Lau A, Chung H, Komada T, Platnich JM, Sandall CF, Choudhury SR, Chun J, Naumenko V, Surewaard BG, Nelson MC, Ulke-Lemee A, Beck PL, Benediktsson H, Jevnikar AM, Snelgrove SL, Hickey MJ, Senger DL, James MT, Macdonald JA, Kubes P, Jenne CN, Muruve DA. J Clin Invest. 2018 Jul 2;128(7):2894-2913. doi: 10.1172/JCI96640. Epub 2018 Jun 4. PubMed
Dimer-specific immunoprecipitation of active caspase-2 identifies TRAF proteins as novel activators. Robeson AC, Lindblom KR, Wojton J, Kornbluth S, Matsuura K. EMBO J. 2018 Jul 13;37(14). pii: embj.201797072. doi: 10.15252/embj.201797072. Epub 2018 Jun 6. PubMed
Weibel-Palade Body Localized Syntaxin-3 Modulates Von Willebrand Factor Secretion From Endothelial Cells. Schillemans M, Karampini E, van den Eshof BL, Gangaev A, Hofman M, van Breevoort D, Meems H, Janssen H, Mulder AA, Jost CR, Escher JC, Adam R, Carter T, Koster AJ, van den Biggelaar M, Voorberg J, Bierings R. Arterioscler Thromb Vasc Biol. 2018 Jul;38(7):1549-1561. doi: 10.1161/ATVBAHA.117.310701. Epub 2018 Jun 7. PubMed
Pharmacological inhibition of dihydroorotate dehydrogenase induces apoptosis and differentiation in acute myeloid leukemia cells. Wu D, Wang W, Chen W, Lian F, Lang L, Huang Y, Xu Y, Zhang N, Chen Y, Liu M, Nussinov R, Cheng F, Lu W, Huang J. Haematologica. 2018 Sep;103(9):1472-1483. doi: 10.3324/haematol.2018.188185. Epub 2018 Jun 7. PubMed
The transcription factor Zfp90 regulates the self-renewal and differentiation of hematopoietic stem cells. Liu T, Kong WX, Tang XY, Xu M, Wang QH, Zhang B, Hu LD, Chen H. Cell Death Dis. 2018 Jun 7;9(6):677. doi: 10.1038/s41419-018-0721-8. PubMed
Metformin induces FOXO3-dependent fetal hemoglobin production in human primary erythroid cells. Zhang Y, Paikari A, Sumazin P, Ginter Summarell CC, Crosby JR, Boerwinkle E, Weiss MJ, Sheehan VA. Blood. 2018 Jul 19;132(3):321-333. doi: 10.1182/blood-2017-11-814335. Epub 2018 Jun 8. PubMed
TET1-Mediated Hypomethylation Activates Oncogenic Signaling in Triple-Negative Breast Cancer. Good CR, Panjarian S, Kelly AD, Madzo J, Patel B, Jelinek J, Issa JJ. Cancer Res. 2018 Aug 1;78(15):4126-4137. doi: 10.1158/0008-5472.CAN-17-2082. Epub 2018 Jun 11. PubMed
A Testosterone Metabolite 19-Hydroxyandrostenedione Induces Neuroendocrine Trans-Differentiation of Prostate Cancer Cells via an Ectopic Olfactory Receptor. Abaffy T, Bain JR, Muehlbauer MJ, Spasojevic I, Lodha S, Bruguera E, O'Neal SK, Kim SY, Matsunami H. Front Oncol. 2018 May 28;8:162. doi: 10.3389/fonc.2018.00162. eCollection 2018. PubMed
Nicotinamide adenine dinucleotide is transported into mammalian mitochondria. Davila A, Liu L, Chellappa K, Redpath P, Nakamaru-Ogiso E, Paolella LM, Zhang Z, Migaud ME, Rabinowitz JD, Baur JA. Elife. 2018 Jun 12;7. pii: 33246. doi: 10.7554/eLife.33246. PubMed
Selective Loss of PARG Restores PARylation and Counteracts PARP Inhibitor-Mediated Synthetic Lethality. Gogola E, Duarte AA, de Ruiter JR, Wiegant WW, Schmid JA, de Bruijn R, James DI, Guerrero Llobet S, Vis DJ, Annunziato S, van den Broek B, Barazas M, Kersbergen A, van de Ven M, Tarsounas M, Ogilvie DJ, van Vugt M, Wessels LFA, Bartkova J, Gromova I, Andujar-Sanchez M, Bartek J, Lopes M, van Attikum H, Borst P, Jonkers J, Rottenberg S. Cancer Cell. 2018 Jun 11;33(6):1078-1093.e12. doi: 10.1016/j.ccell.2018.05.008. PubMed
iTAP, a novel iRhom interactor, controls TNF secretion by policing the stability of iRhom/TACE. Oikonomidi I, Burbridge E, Cavadas M, Sullivan G, Collis B, Naegele H, Clancy D, Brezinova J, Hu T, Bileck A, Gerner C, Bolado A, von Kriegsheim A, Martin SJ, Steinberg F, Strisovsky K, Adrain C. Elife. 2018 Jun 13;7. pii: 35032. doi: 10.7554/eLife.35032. PubMed
EWS/ETS-Driven Ewing Sarcoma Requires BET Bromodomain Proteins. Gollavilli PN, Pawar A, Wilder-Romans K, Natesan R, Engelke CG, Dommeti VL, Krishnamurthy PM, Nallasivam A, Apel IJ, Xu T, Qin ZS, Feng FY, Asangani IA. Cancer Res. 2018 Aug 15;78(16):4760-4773. doi: 10.1158/0008-5472.CAN-18-0484. Epub 2018 Jun 13. PubMed
Induction of apoptosis and suppression of tumor growth by Nur77-derived Bcl-2 converting peptide in chemoresistant lung cancer cells. Pearce MC, Gamble JT, Kopparapu PR, O'Donnell EF, Mueller MJ, Jang HS, Greenwood JA, Satterthwait AC, Tanguay RL, Zhang XK, Kolluri SK. Oncotarget. 2018 May 25;9(40):26072-26085. doi: 10.18632/oncotarget.25437. eCollection 2018 May 25. PubMed
Gas41 links histone acetylation to H2A.Z deposition and maintenance of embryonic stem cell identity. Hsu CC, Zhao D, Shi J, Peng D, Guan H, Li Y, Huang Y, Wen H, Li W, Li H, Shi X. Cell Discov. 2018 Jun 12;4:28. doi: 10.1038/s41421-018-0027-0. eCollection 2018. PubMed
Flaviviruses Exploit the Lipid Droplet Protein AUP1 to Trigger Lipophagy and Drive Virus Production. Zhang J, Lan Y, Li MY, Lamers MM, Fusade-Boyer M, Klemm E, Thiele C, Ashour J, Sanyal S. Cell Host Microbe. 2018 Jun 13;23(6):819-831.e5. doi: 10.1016/j.chom.2018.05.005. PubMed
Megalin mediates plasma membrane to mitochondria cross-talk and regulates mitochondrial metabolism. Li Q, Lei F, Tang Y, Pan JS, Tong Q, Sun Y, Sheikh-Hamad D. Cell Mol Life Sci. 2018 Nov;75(21):4021-4040. doi: 10.1007/s00018-018-2847-3. Epub 2018 Jun 9. PubMed
A multiprotein supercomplex controlling oncogenic signalling in lymphoma. Phelan JD, Young RM, Webster DE, Roulland S, Wright GW, Kasbekar M, Shaffer AL 3rd, Ceribelli M, Wang JQ, Schmitz R, Nakagawa M, Bachy E, Huang DW, Ji Y, Chen L, Yang Y, Zhao H, Yu X, Xu W, Palisoc MM, Valadez RR, Davies-Hill T, Wilson WH, Chan WC, Jaffe ES, Gascoyne RD, Campo E, Rosenwald A, Ott G, Delabie J, Rimsza LM, Rodriguez FJ, Estephan F, Holdhoff M, Kruhlak MJ, Hewitt SM, Thomas CJ, Pittaluga S, Oellerich T, Staudt LM. Nature. 2018 Aug;560(7718):387-391. doi: 10.1038/s41586-018-0290-0. Epub 2018 Jun 20. PubMed
Calcium store refilling and STIM activation in STIM- and Orai-deficient cell lines. Zheng S, Zhou L, Ma G, Zhang T, Liu J, Li J, Nguyen NT, Zhang X, Li W, Nwokonko R, Zhou Y, Zhao F, Liu J, Huang Y, Gill DL, Wang Y. Pflugers Arch. 2018 Oct;470(10):1555-1567. doi: 10.1007/s00424-018-2165-5. Epub 2018 Jun 22. PubMed
Mutant GNAS drives pancreatic tumourigenesis by inducing PKA-mediated SIK suppression and reprogramming lipid metabolism. Patra KC, Kato Y, Mizukami Y, Widholz S, Boukhali M, Revenco I, Grossman EA, Ji F, Sadreyev RI, Liss AS, Screaton RA, Sakamoto K, Ryan DP, Mino-Kenudson M, Castillo CF, Nomura DK, Haas W, Bardeesy N. Nat Cell Biol. 2018 Jul;20(7):811-822. doi: 10.1038/s41556-018-0122-3. Epub 2018 Jun 25. PubMed
Promoter interactome of human embryonic stem cell-derived cardiomyocytes connects GWAS regions to cardiac gene networks. Choy MK, Javierre BM, Williams SG, Baross SL, Liu Y, Wingett SW, Akbarov A, Wallace C, Freire-Pritchett P, Rugg-Gunn PJ, Spivakov M, Fraser P, Keavney BD. Nat Commun. 2018 Jun 28;9(1):2526. doi: 10.1038/s41467-018-04931-0. PubMed
Genome-scale analysis identifies paralog lethality as a vulnerability of chromosome 1p loss in cancer. Viswanathan SR, Nogueira MF, Buss CG, Krill-Burger JM, Wawer MJ, Malolepsza E, Berger AC, Choi PS, Shih J, Taylor AM, Tanenbaum B, Pedamallu CS, Cherniack AD, Tamayo P, Strathdee CA, Lage K, Carr SA, Schenone M, Bhatia SN, Vazquez F, Tsherniak A, Hahn WC, Meyerson M. Nat Genet. 2018 Jul;50(7):937-943. doi: 10.1038/s41588-018-0155-3. Epub 2018 Jun 28. PubMed
The transcription-coupled DNA repair-initiating protein CSB promotes XRCC1 recruitment to oxidative DNA damage. Menoni H, Wienholz F, Theil AF, Janssens RC, Lans H, Campalans A, Radicella JP, Marteijn JA, Vermeulen W. Nucleic Acids Res. 2018 Sep 6;46(15):7747-7756. doi: 10.1093/nar/gky579. PubMed
CBFbeta-SMMHC Inhibition Triggers Apoptosis by Disrupting MYC Chromatin Dynamics in Acute Myeloid Leukemia. Pulikkan JA, Hegde M, Ahmad HM, Belaghzal H, Illendula A, Yu J, O'Hagan K, Ou J, Muller-Tidow C, Wolfe SA, Zhu LJ, Dekker J, Bushweller JH, Castilla LH. Cell. 2018 Jun 28;174(1):172-186.e21. doi: 10.1016/j.cell.2018.05.048. PubMed
Tumor Cell-Intrinsic Factors Underlie Heterogeneity of Immune Cell Infiltration and Response to Immunotherapy. Li J, Byrne KT, Yan F, Yamazoe T, Chen Z, Baslan T, Richman LP, Lin JH, Sun YH, Rech AJ, Balli D, Hay CA, Sela Y, Merrell AJ, Liudahl SM, Gordon N, Norgard RJ, Yuan S, Yu S, Chao T, Ye S, Eisinger-Mathason TSK, Faryabi RB, Tobias JW, Lowe SW, Coussens LM, Wherry EJ, Vonderheide RH, Stanger BZ. Immunity. 2018 Jul 17;49(1):178-193.e7. doi: 10.1016/j.immuni.2018.06.006. Epub 2018 Jun 26. PubMed
Differential expression and function of CAIX and CAXII in breast cancer: A comparison between tumorgraft models and cells. Chen Z, Ai L, Mboge MY, Tu C, McKenna R, Brown KD, Heldermon CD, Frost SC. PLoS One. 2018 Jul 2;13(7):e0199476. doi: 10.1371/journal.pone.0199476. eCollection 2018. PubMed
PB1 and UBA domains of p62 are essential for aggresome-like induced structure formation. Cabe M, Rademacher DJ, Karlsson AB, Cherukuri S, Bakowska JC. Biochem Biophys Res Commun. 2018 Sep 18;503(4):2306-2311. doi: 10.1016/j.bbrc.2018.06.153. Epub 2018 Jul 2. PubMed
Photobiomodulation therapy promotes in vitro wound healing in nicastrin KO HaCaT cells. Tricarico PM, Zupin L, Ottaviani G, Pacor S, Jean-Louis F, Boniotto M, Crovella S. J Biophotonics. 2018 Dec;11(12):e201800174. doi: 10.1002/jbio.201800174. Epub 2018 Jul 24. PubMed
Long isoform of VEGF stimulates cell migration of breast cancer by filopodia formation via NRP1/ARHGAP17/Cdc42 regulatory network. Kiso M, Tanaka S, Saji S, Toi M, Sato F. Int J Cancer. 2018 Dec 1;143(11):2905-2918. doi: 10.1002/ijc.31645. Epub 2018 Oct 9. PubMed
Caspase-independent cell death does not elicit a proliferative response in melanoma cancer cells. Roumane A, Berthenet K, El Fassi C, Ichim G. BMC Cell Biol. 2018 Jul 4;19(1):11. doi: 10.1186/s12860-018-0164-1. PubMed
microRNA-122 amplifies hepatitis C virus translation by shaping the structure of the internal ribosomal entry site. Schult P, Roth H, Adams RL, Mas C, Imbert L, Orlik C, Ruggieri A, Pyle AM, Lohmann V. Nat Commun. 2018 Jul 4;9(1):2613. doi: 10.1038/s41467-018-05053-3. PubMed
CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions. Zimmermann M, Murina O, Reijns MAM, Agathanggelou A, Challis R, Tarnauskaite Z, Muir M, Fluteau A, Aregger M, McEwan A, Yuan W, Clarke M, Lambros MB, Paneesha S, Moss P, Chandrashekhar M, Angers S, Moffat J, Brunton VG, Hart T, de Bono J, Stankovic T, Jackson AP, Durocher D. Nature. 2018 Jul;559(7713):285-289. doi: 10.1038/s41586-018-0291-z. Epub 2018 Jul 4. PubMed
ERCC2 Helicase Domain Mutations Confer Nucleotide Excision Repair Deficiency and Drive Cisplatin Sensitivity in Muscle-Invasive Bladder Cancer. Li Q, Damish AW, Frazier Z, Liu D, Reznichenko E, Kamburov A, Bell A, Zhao H, Jordan EJ, Gao SP, Ma J, Abbosh PH, Bellmunt J, Plimack ER, Lazaro JB, Solit DB, Bajorin D, Rosenberg JE, D'Andrea AD, Riaz N, Van Allen EM, Iyer G, Mouw KW. Clin Cancer Res. 2019 Feb 1;25(3):977-988. doi: 10.1158/1078-0432.CCR-18-1001. Epub 2018 Jul 6. PubMed
Histone variant H2A.Z deposition and acetylation directs the canonical Notch signaling response. Giaimo BD, Ferrante F, Vallejo DM, Hein K, Gutierrez-Perez I, Nist A, Stiewe T, Mittler G, Herold S, Zimmermann T, Bartkuhn M, Schwarz P, Oswald F, Dominguez M, Borggrefe T. Nucleic Acids Res. 2018 Sep 19;46(16):8197-8215. doi: 10.1093/nar/gky551. PubMed
Strain-Specific Contribution of Eukaryotic Elongation Factor 1 Gamma to the Translation of Influenza A Virus Proteins. Sammaibashi S, Yamayoshi S, Kawaoka Y. Front Microbiol. 2018 Jun 29;9:1446. doi: 10.3389/fmicb.2018.01446. eCollection 2018. PubMed
Unique BIR domain sets determine inhibitor of apoptosis protein-driven cell death and NOD2 complex signal specificity. Chirieleison SM, Rathkey JK, Abbott DW. Sci Signal. 2018 Jul 17;11(539). pii: 11/539/eaao3964. doi: 10.1126/scisignal.aao3964. PubMed
The shieldin complex mediates 53BP1-dependent DNA repair. Noordermeer SM, Adam S, Setiaputra D, Barazas M, Pettitt SJ, Ling AK, Olivieri M, Alvarez-Quilon A, Moatti N, Zimmermann M, Annunziato S, Krastev DB, Song F, Brandsma I, Frankum J, Brough R, Sherker A, Landry S, Szilard RK, Munro MM, McEwan A, Goullet de Rugy T, Lin ZY, Hart T, Moffat J, Gingras AC, Martin A, van Attikum H, Jonkers J, Lord CJ, Rottenberg S, Durocher D. Nature. 2018 Aug;560(7716):117-121. doi: 10.1038/s41586-018-0340-7. Epub 2018 Jul 18. PubMed

Associated Plasmids

PRMT5-mediated regulation of developmental myelination. Scaglione A, Patzig J, Liang J, Frawley R, Bok J, Mela A, Yattah C, Zhang J, Teo SX, Zhou T, Chen S, Bernstein E, Canoll P, Guccione E, Casaccia P. Nat Commun. 2018 Jul 19;9(1):2840. doi: 10.1038/s41467-018-04863-9. PubMed
NAT6 acetylates the N-terminus of different forms of actin. Wiame E, Tahay G, Tyteca D, Vertommen D, Stroobant V, Bommer GT, Van Schaftingen E. FEBS J. 2018 Sep;285(17):3299-3316. doi: 10.1111/febs.14605. Epub 2018 Aug 13. PubMed
Parvovirus minute virus of mice interacts with sites of cellular DNA damage to establish and amplify its lytic infection. Majumder K, Wang J, Boftsi M, Fuller MS, Rede JE, Joshi T, Pintel DJ. Elife. 2018 Jul 20;7. pii: 37750. doi: 10.7554/eLife.37750. PubMed
Recurrent homozygous deletion of DROSHA and microduplication of PDE4DIP in pineoblastoma. Snuderl M, Kannan K, Pfaff E, Wang S, Stafford JM, Serrano J, Heguy A, Ray K, Faustin A, Aminova O, Dolgalev I, Stapleton SL, Zagzag D, Chiriboga L, Gardner SL, Wisoff JH, Golfinos JG, Capper D, Hovestadt V, Rosenblum MK, Placantonakis DG, LeBoeuf SE, Papagiannakopoulos TY, Chavez L, Ahsan S, Eberhart CG, Pfister SM, Jones DTW, Karajannis MA. Nat Commun. 2018 Jul 20;9(1):2868. doi: 10.1038/s41467-018-05029-3. PubMed
T-Synthase Deficiency Enhances Oncogenic Features in Human Colorectal Cancer Cells via Activation of Epithelial-Mesenchymal Transition. Dong X, Jiang Y, Liu J, Liu Z, Gao T, An G, Wen T. Biomed Res Int. 2018 Jun 21;2018:9532389. doi: 10.1155/2018/9532389. eCollection 2018. PubMed
Elesclomol restores mitochondrial function in genetic models of copper deficiency. Soma S, Latimer AJ, Chun H, Vicary AC, Timbalia SA, Boulet A, Rahn JJ, Chan SSL, Leary SC, Kim BE, Gitlin JD, Gohil VM. Proc Natl Acad Sci U S A. 2018 Aug 7;115(32):8161-8166. doi: 10.1073/pnas.1806296115. Epub 2018 Jul 23. PubMed
Exposure to galactic cosmic radiation compromises DNA repair and increases the potential for oncogenic chromosomal rearrangement in bronchial epithelial cells. Li Z, Jella KK, Jaafar L, Li S, Park S, Story MD, Wang H, Wang Y, Dynan WS. Sci Rep. 2018 Jul 23;8(1):11038. doi: 10.1038/s41598-018-29350-5. PubMed
Epigenome editing of microsatellite repeats defines tumor-specific enhancer functions and dependencies. Boulay G, Volorio A, Iyer S, Broye LC, Stamenkovic I, Riggi N, Rivera MN. Genes Dev. 2018 Aug 1;32(15-16):1008-1019. doi: 10.1101/gad.315192.118. Epub 2018 Jul 24. PubMed
Inosine Monophosphate Dehydrogenase Dependence in a Subset of Small Cell Lung Cancers. Huang F, Ni M, Chalishazar MD, Huffman KE, Kim J, Cai L, Shi X, Cai F, Zacharias LG, Ireland AS, Li K, Gu W, Kaushik AK, Liu X, Gazdar AF, Oliver TG, Minna JD, Hu Z, DeBerardinis RJ. Cell Metab. 2018 Sep 4;28(3):369-382.e5. doi: 10.1016/j.cmet.2018.06.005. Epub 2018 Jun 28. PubMed
Genome-scale CRISPR-Cas9 screen identifies druggable dependencies in TP53 wild-type Ewing sarcoma. Stolte B, Iniguez AB, Dharia NV, Robichaud AL, Conway AS, Morgan AM, Alexe G, Schauer NJ, Liu X, Bird GH, Tsherniak A, Vazquez F, Buhrlage SJ, Walensky LD, Stegmaier K. J Exp Med. 2018 Aug 6;215(8):2137-2155. doi: 10.1084/jem.20171066. Epub 2018 Jul 25. PubMed
Accumulation of 8,9-unsaturated sterols drives oligodendrocyte formation and remyelination. Hubler Z, Allimuthu D, Bederman I, Elitt MS, Madhavan M, Allan KC, Shick HE, Garrison E, T Karl M, Factor DC, Nevin ZS, Sax JL, Thompson MA, Fedorov Y, Jin J, Wilson WK, Giera M, Bracher F, Miller RH, Tesar PJ, Adams DJ. Nature. 2018 Aug;560(7718):372-376. doi: 10.1038/s41586-018-0360-3. Epub 2018 Jul 25. PubMed
Mitochondrial inner membrane permeabilisation enables mtDNA release during apoptosis. Riley JS, Quarato G, Cloix C, Lopez J, O'Prey J, Pearson M, Chapman J, Sesaki H, Carlin LM, Passos JF, Wheeler AP, Oberst A, Ryan KM, Tait SW. EMBO J. 2018 Sep 3;37(17). pii: embj.201899238. doi: 10.15252/embj.201899238. Epub 2018 Jul 26. PubMed

Associated Plasmids

Frontline Science: RIP2 promotes house dust mite-induced allergic airway inflammation. Miller MH, Shehat MG, Alcedo KP, Spinel LP, Soulakova J, Tigno-Aranjuez JT. J Leukoc Biol. 2018 Sep;104(3):447-459. doi: 10.1002/JLB.4HI0118-017RR. Epub 2018 Jul 27. PubMed
Transient p53 inhibition sensitizes aged white adipose tissue for beige adipocyte recruitment by blocking mitophagy. Fu W, Liu Y, Sun C, Yin H. FASEB J. 2019 Jan;33(1):844-856. doi: 10.1096/fj.201800577R. Epub 2018 Jul 27. PubMed
A novel enhancer regulates MGMT expression and promotes temozolomide resistance in glioblastoma. Chen X, Zhang M, Gan H, Wang H, Lee JH, Fang D, Kitange GJ, He L, Hu Z, Parney IF, Meyer FB, Giannini C, Sarkaria JN, Zhang Z. Nat Commun. 2018 Jul 27;9(1):2949. doi: 10.1038/s41467-018-05373-4. PubMed
An Unbiased Screen for Human Cytomegalovirus Identifies Neuropilin-2 as a Central Viral Receptor. Martinez-Martin N, Marcandalli J, Huang CS, Arthur CP, Perotti M, Foglierini M, Ho H, Dosey AM, Shriver S, Payandeh J, Leitner A, Lanzavecchia A, Perez L, Ciferri C. Cell. 2018 Aug 23;174(5):1158-1171.e19. doi: 10.1016/j.cell.2018.06.028. Epub 2018 Jul 26. PubMed
Targeting the HTLV-I-Regulated BATF3/IRF4 Transcriptional Network in Adult T Cell Leukemia/Lymphoma. Nakagawa M, Shaffer AL 3rd, Ceribelli M, Zhang M, Wright G, Huang DW, Xiao W, Powell J, Petrus MN, Yang Y, Phelan JD, Kohlhammer H, Dubois SP, Yoo HM, Bachy E, Webster DE, Yang Y, Xu W, Yu X, Zhao H, Bryant BR, Shimono J, Ishio T, Maeda M, Green PL, Waldmann TA, Staudt LM. Cancer Cell. 2018 Aug 13;34(2):286-297.e10. doi: 10.1016/j.ccell.2018.06.014. Epub 2018 Jul 26. PubMed
PTE, a novel module to target Polycomb Repressive Complex 1 to the human cyclin D2 (CCND2) oncogene. Cameron SR, Nandi S, Kahn TG, Barrasa JI, Stenberg P, Schwartz YB. J Biol Chem. 2018 Sep 14;293(37):14342-14358. doi: 10.1074/jbc.RA118.005010. Epub 2018 Aug 1. PubMed
Nonsteroidal Anti-inflammatory Drugs Potently Inhibit the Replication of Zika Viruses by Inducing the Degradation of AXL. Pan T, Peng Z, Tan L, Zou F, Zhou N, Liu B, Liang L, Chen C, Liu J, Wu L, Liu G, Peng Z, Liu W, Ma X, Zhang J, Zhu X, Liu T, Li M, Huang X, Tao L, Zhang Y, Zhang H. J Virol. 2018 Sep 26;92(20). pii: JVI.01018-18. doi: 10.1128/JVI.01018-18. Print 2018 Oct 15. PubMed
HIV-1 Employs Multiple Mechanisms To Resist Cas9/Single Guide RNA Targeting the Viral Primer Binding Site. Wang Z, Wang W, Cui YC, Pan Q, Zhu W, Gendron P, Guo F, Cen S, Witcher M, Liang C. J Virol. 2018 Sep 26;92(20). pii: JVI.01135-18. doi: 10.1128/JVI.01135-18. Print 2018 Oct 15. PubMed
Mutant LKB1 Confers Enhanced Radiosensitization in Combination with Trametinib in KRAS-Mutant Non-Small Cell Lung Cancer. Wang Y, Li N, Jiang W, Deng W, Ye R, Xu C, Qiao Y, Sharma A, Zhang M, Hung MC, Lin SH. Clin Cancer Res. 2018 Nov 15;24(22):5744-5756. doi: 10.1158/1078-0432.CCR-18-1489. Epub 2018 Aug 1. PubMed
Inositol phosphates are assembly co-factors for HIV-1. Dick RA, Zadrozny KK, Xu C, Schur FKM, Lyddon TD, Ricana CL, Wagner JM, Perilla JR, Ganser-Pornillos BK, Johnson MC, Pornillos O, Vogt VM. Nature. 2018 Aug;560(7719):509-512. doi: 10.1038/s41586-018-0396-4. Epub 2018 Aug 1. PubMed
A VP1 mutation acquired during an enterovirus 71 disseminated infection confers heparan sulfate binding ability and modulates ex vivo tropism. Tseligka ED, Sobo K, Stoppini L, Cagno V, Abdul F, Piuz I, Meylan P, Huang S, Constant S, Tapparel C. PLoS Pathog. 2018 Aug 3;14(8):e1007190. doi: 10.1371/journal.ppat.1007190. eCollection 2018 Aug. PubMed
ER-to-lysosome-associated degradation of proteasome-resistant ATZ polymers occurs via receptor-mediated vesicular transport. Fregno I, Fasana E, Bergmann TJ, Raimondi A, Loi M, Solda T, Galli C, D'Antuono R, Morone D, Danieli A, Paganetti P, van Anken E, Molinari M. EMBO J. 2018 Sep 3;37(17). pii: embj.201899259. doi: 10.15252/embj.201899259. Epub 2018 Aug 3. PubMed
OAS1 and OAS3 negatively regulate the expression of chemokines and interferon-responsive genes in human macrophages. Lee WB, Choi WY, Lee DH, Shim H, Kim-Ha J, Kim YJ. BMB Rep. 2019 Feb;52(2):133-138. PubMed
Reconstruction of the cell entry pathway of an extinct virus. Robinson-McCarthy LR, McCarthy KR, Raaben M, Piccinotti S, Nieuwenhuis J, Stubbs SH, Bakkers MJG, Whelan SPJ. PLoS Pathog. 2018 Aug 6;14(8):e1007123. doi: 10.1371/journal.ppat.1007123. eCollection 2018 Aug. PubMed
Somatic loss of WWOX is associated with TP53 perturbation in basal-like breast cancer. Abdeen SK, Ben-David U, Shweiki A, Maly B, Aqeilan RI. Cell Death Dis. 2018 Aug 6;9(8):832. doi: 10.1038/s41419-018-0896-z. PubMed
TSC1 and DEPDC5 regulate HIV-1 latency through the mTOR signaling pathway. Jin S, Liao Q, Chen J, Zhang L, He Q, Zhu H, Zhang X, Xu J. Emerg Microbes Infect. 2018 Aug 8;7(1):138. doi: 10.1038/s41426-018-0139-5. PubMed
Selective targeting of KRAS oncogenic alleles by CRISPR/Cas9 inhibits proliferation of cancer cells. Lee W, Lee JH, Jun S, Lee JH, Bang D. Sci Rep. 2018 Aug 8;8(1):11879. doi: 10.1038/s41598-018-30205-2. PubMed
Genome-wide CRISPR screen identifies TMEM41B as a gene required for autophagosome formation. Morita K, Hama Y, Izume T, Tamura N, Ueno T, Yamashita Y, Sakamaki Y, Mimura K, Morishita H, Shihoya W, Nureki O, Mano H, Mizushima N. J Cell Biol. 2018 Aug 9. pii: jcb.201804132. doi: 10.1083/jcb.201804132. PubMed

Associated Plasmids

Genome Editing of Human Primary Keratinocytes by CRISPR/Cas9 Reveals an Essential Role of the NLRP1 Inflammasome in UVB Sensing. Fenini G, Grossi S, Contassot E, Biedermann T, Reichmann E, French LE, Beer HD. J Invest Dermatol. 2018 Dec;138(12):2644-2652. doi: 10.1016/j.jid.2018.07.016. Epub 2018 Aug 7. PubMed
Pharmacological targeting of p38 MAP-Kinase 6 (MAP2K6) inhibits the growth of esophageal adenocarcinoma. Lin S, Liu K, Zhang Y, Jiang M, Lu R, Folts CJ, Gao X, Noble MD, Zhao T, Zhou Z, Lan X, Que J. Cell Signal. 2018 Nov;51:222-232. doi: 10.1016/j.cellsig.2018.08.008. Epub 2018 Aug 11. PubMed
Gambogic Acid and Its Analogs Inhibit Gap Junctional Intercellular Communication. Choi EJ, Yeo JH, Yoon SM, Lee J. Front Pharmacol. 2018 Jul 30;9:814. doi: 10.3389/fphar.2018.00814. eCollection 2018. PubMed
Tuning of human MAIT cell activation by commensal bacteria species and MR1-dependent T-cell presentation. Tastan C, Karhan E, Zhou W, Fleming E, Voigt AY, Yao X, Wang L, Horne M, Placek L, Kozhaya L, Oh J, Unutmaz D. Mucosal Immunol. 2018 Nov;11(6):1591-1605. doi: 10.1038/s41385-018-0072-x. Epub 2018 Aug 16. PubMed
Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1. Cha JH, Yang WH, Xia W, Wei Y, Chan LC, Lim SO, Li CW, Kim T, Chang SS, Lee HH, Hsu JL, Wang HL, Kuo CW, Chang WC, Hadad S, Purdie CA, McCoy AM, Cai S, Tu Y, Litton JK, Mittendorf EA, Moulder SL, Symmans WF, Thompson AM, Piwnica-Worms H, Chen CH, Khoo KH, Hung MC. Mol Cell. 2018 Aug 16;71(4):606-620.e7. doi: 10.1016/j.molcel.2018.07.030. PubMed
An Mtb-Human Protein-Protein Interaction Map Identifies a Switch between Host Antiviral and Antibacterial Responses. Penn BH, Netter Z, Johnson JR, Von Dollen J, Jang GM, Johnson T, Ohol YM, Maher C, Bell SL, Geiger K, Golovkine G, Du X, Choi A, Parry T, Mohapatra BC, Storck MD, Band H, Chen C, Jager S, Shales M, Portnoy DA, Hernandez R, Coscoy L, Cox JS, Krogan NJ. Mol Cell. 2018 Aug 16;71(4):637-648.e5. doi: 10.1016/j.molcel.2018.07.010. PubMed
A Role for p53 in the Adaptation to Glutamine Starvation through the Expression of SLC1A3. Tajan M, Hock AK, Blagih J, Robertson NA, Labuschagne CF, Kruiswijk F, Humpton TJ, Adams PD, Vousden KH. Cell Metab. 2018 Nov 6;28(5):721-736.e6. doi: 10.1016/j.cmet.2018.07.005. Epub 2018 Aug 16. PubMed
Cytosolic Aspartate Availability Determines Cell Survival When Glutamine Is Limiting. Alkan HF, Walter KE, Luengo A, Madreiter-Sokolowski CT, Stryeck S, Lau AN, Al-Zoughbi W, Lewis CA, Thomas CJ, Hoefler G, Graier WF, Madl T, Vander Heiden MG, Bogner-Strauss JG. Cell Metab. 2018 Nov 6;28(5):706-720.e6. doi: 10.1016/j.cmet.2018.07.021. Epub 2018 Aug 16. PubMed
Modified penetrance of coding variants by cis-regulatory variation contributes to disease risk. Castel SE, Cervera A, Mohammadi P, Aguet F, Reverter F, Wolman A, Guigo R, Iossifov I, Vasileva A, Lappalainen T. Nat Genet. 2018 Sep;50(9):1327-1334. doi: 10.1038/s41588-018-0192-y. Epub 2018 Aug 20. PubMed
Thioridazine inhibits self-renewal in breast cancer cells via DRD2-dependent STAT3 inhibition, but induces a G1 arrest independent of DRD2. Tegowski M, Fan C, Baldwin AS. J Biol Chem. 2018 Oct 12;293(41):15977-15990. doi: 10.1074/jbc.RA118.003719. Epub 2018 Aug 21. PubMed
Positive Regulation of Transcription by Human ZMYND8 through Its Association with P-TEFb Complex. Ghosh K, Tang M, Kumari N, Nandy A, Basu S, Mall DP, Rai K, Biswas D. Cell Rep. 2018 Aug 21;24(8):2141-2154.e6. doi: 10.1016/j.celrep.2018.07.064. PubMed
Genetic modifiers of the BRD4-NUT dependency of NUT midline carcinoma uncovers a synergism between BETis and CDK4/6is. Liao S, Maertens O, Cichowski K, Elledge SJ. Genes Dev. 2018 Sep 1;32(17-18):1188-1200. doi: 10.1101/gad.315648.118. Epub 2018 Aug 22. PubMed
MAIT cells protect against pulmonary Legionella longbeachae infection. Wang H, D'Souza C, Lim XY, Kostenko L, Pediongco TJ, Eckle SBG, Meehan BS, Shi M, Wang N, Li S, Liu L, Mak JYW, Fairlie DP, Iwakura Y, Gunnersen JM, Stent AW, Godfrey DI, Rossjohn J, Westall GP, Kjer-Nielsen L, Strugnell RA, McCluskey J, Corbett AJ, Hinks TSC, Chen Z. Nat Commun. 2018 Aug 22;9(1):3350. doi: 10.1038/s41467-018-05202-8. PubMed
RAP2 mediates mechanoresponses of the Hippo pathway. Meng Z, Qiu Y, Lin KC, Kumar A, Placone JK, Fang C, Wang KC, Lu S, Pan M, Hong AW, Moroishi T, Luo M, Plouffe SW, Diao Y, Ye Z, Park HW, Wang X, Yu FX, Chien S, Wang CY, Ren B, Engler AJ, Guan KL. Nature. 2018 Aug;560(7720):655-660. doi: 10.1038/s41586-018-0444-0. Epub 2018 Aug 22. PubMed
Dysregulated hemolysin liberates bacterial outer membrane vesicles for cytosolic lipopolysaccharide sensing. Chen S, Yang D, Wen Y, Jiang Z, Zhang L, Jiang J, Chen Y, Hu T, Wang Q, Zhang Y, Liu Q. PLoS Pathog. 2018 Aug 23;14(8):e1007240. doi: 10.1371/journal.ppat.1007240. eCollection 2018 Aug. PubMed
CUEDC1 is a primary target of ERalpha essential for the growth of breast cancer cells. Lopes R, Korkmaz G, Revilla SA, van Vliet R, Nagel R, Custers L, Kim Y, van Breugel PC, Zwart W, Moumbeini B, Manber Z, Elkon R, Agami R. Cancer Lett. 2018 Nov 1;436:87-95. doi: 10.1016/j.canlet.2018.08.018. Epub 2018 Aug 23. PubMed
TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging. Xu D, Jin T, Zhu H, Chen H, Ofengeim D, Zou C, Mifflin L, Pan L, Amin P, Li W, Shan B, Naito MG, Meng H, Li Y, Pan H, Aron L, Adiconis X, Levin JZ, Yankner BA, Yuan J. Cell. 2018 Sep 6;174(6):1477-1491.e19. doi: 10.1016/j.cell.2018.07.041. Epub 2018 Aug 23. PubMed
Human tryptophanyl-tRNA synthetase is an IFN-gamma-inducible entry factor for Enterovirus. Yeung ML, Jia L, Yip CCY, Chan JFW, Teng JLL, Chan KH, Cai JP, Zhang C, Zhang AJ, Wong WM, Kok KH, Lau SKP, Woo PCY, Lo JYC, Jin DY, Shih SR, Yuen KY. J Clin Invest. 2018 Nov 1;128(11):5163-5177. doi: 10.1172/JCI99411. Epub 2018 Oct 15. PubMed
Transcription Factor PROX1 Suppresses Notch Pathway Activation via the Nucleosome Remodeling and Deacetylase Complex in Colorectal Cancer Stem-like Cells. Hogstrom J, Heino S, Kallio P, Lahde M, Leppanen VM, Balboa D, Wiener Z, Alitalo K. Cancer Res. 2018 Oct 15;78(20):5820-5832. doi: 10.1158/0008-5472.CAN-18-0451. Epub 2018 Aug 28. PubMed
The LTB4-BLT1 axis regulates the polarized trafficking of chemoattractant GPCRs during neutrophil chemotaxis. Subramanian BC, Moissoglu K, Parent CA. J Cell Sci. 2018 Sep 21;131(18). pii: jcs.217422. doi: 10.1242/jcs.217422. PubMed
Nrf2 negatively regulates STING indicating a link between antiviral sensing and metabolic reprogramming. Olagnier D, Brandtoft AM, Gunderstofte C, Villadsen NL, Krapp C, Thielke AL, Laustsen A, Peri S, Hansen AL, Bonefeld L, Thyrsted J, Bruun V, Iversen MB, Lin L, Artegoitia VM, Su C, Yang L, Lin R, Balachandran S, Luo Y, Nyegaard M, Marrero B, Goldbach-Mansky R, Motwani M, Ryan DG, Fitzgerald KA, O'Neill LA, Hollensen AK, Damgaard CK, de Paoli FV, Bertram HC, Jakobsen MR, Poulsen TB, Holm CK. Nat Commun. 2018 Aug 29;9(1):3506. doi: 10.1038/s41467-018-05861-7. PubMed
RNF144A sustains EGFR signaling to promote EGF-dependent cell proliferation. Ho SR, Lin WC. J Biol Chem. 2018 Oct 19;293(42):16307-16323. doi: 10.1074/jbc.RA118.002887. Epub 2018 Aug 31. PubMed
Protease-activated receptor 2 (PAR2) upregulates granulocyte colony stimulating factor (G-CSF) expression in breast cancer cells. Carvalho E, Hugo de Almeida V, Rondon AMR, Possik PA, Viola JPB, Monteiro RQ. Biochem Biophys Res Commun. 2018 Sep 26;504(1):270-276. doi: 10.1016/j.bbrc.2018.08.169. Epub 2018 Aug 30. PubMed
Epigenetic and Transcriptomic Profiling of Mammary Gland Development and Tumor Models Disclose Regulators of Cell State Plasticity. Dravis C, Chung CY, Lytle NK, Herrera-Valdez J, Luna G, Trejo CL, Reya T, Wahl GM. Cancer Cell. 2018 Sep 10;34(3):466-482.e6. doi: 10.1016/j.ccell.2018.08.001. Epub 2018 Aug 30. PubMed
Microbiota-derived short-chain fatty acids promote Th1 cell IL-10 production to maintain intestinal homeostasis. Sun M, Wu W, Chen L, Yang W, Huang X, Ma C, Chen F, Xiao Y, Zhao Y, Ma C, Yao S, Carpio VH, Dann SM, Zhao Q, Liu Z, Cong Y. Nat Commun. 2018 Sep 3;9(1):3555. doi: 10.1038/s41467-018-05901-2. PubMed
Local enrichment of HP1alpha at telomeres alters their structure and regulation of telomere protection. Chow TT, Shi X, Wei JH, Guan J, Stadler G, Huang B, Blackburn EH. Nat Commun. 2018 Sep 4;9(1):3583. doi: 10.1038/s41467-018-05840-y. PubMed
Sphingosine-1-phosphate (S1P) induces potent anti-inflammatory effects in vitro and in vivo by S1P receptor 4-mediated suppression of 5-lipoxygenase activity. Fettel J, Kuhn B, Guillen NA, Surun D, Peters M, Bauer R, Angioni C, Geisslinger G, Schnutgen F, Meyer Zu Heringdorf D, Werz O, Meybohm P, Zacharowski K, Steinhilber D, Roos J, Maier TJ. FASEB J. 2019 Feb;33(2):1711-1726. doi: 10.1096/fj.201800221R. Epub 2018 Sep 6. PubMed
Interrogating the protein interactomes of RAS isoforms identifies PIP5K1A as a KRAS-specific vulnerability. Adhikari H, Counter CM. Nat Commun. 2018 Sep 7;9(1):3646. doi: 10.1038/s41467-018-05692-6. PubMed

Associated Plasmids

Inducing CCR5Delta32/Delta32 Homozygotes in the Human Jurkat CD4+ Cell Line and Primary CD4+ Cells by CRISPR-Cas9 Genome-Editing Technology. Qi C, Li D, Jiang X, Jia X, Lu L, Wang Y, Sun J, Shao Y, Wei M. Mol Ther Nucleic Acids. 2018 Sep 7;12:267-274. doi: 10.1016/j.omtn.2018.05.012. Epub 2018 Jun 17. PubMed
Ex Vivo COL7A1 Correction for Recessive Dystrophic Epidermolysis Bullosa Using CRISPR/Cas9 and Homology-Directed Repair. Izmiryan A, Ganier C, Bovolenta M, Schmitt A, Mavilio F, Hovnanian A. Mol Ther Nucleic Acids. 2018 Sep 7;12:554-567. doi: 10.1016/j.omtn.2018.06.008. Epub 2018 Jun 26. PubMed
BAP1 links metabolic regulation of ferroptosis to tumour suppression. Zhang Y, Shi J, Liu X, Feng L, Gong Z, Koppula P, Sirohi K, Li X, Wei Y, Lee H, Zhuang L, Chen G, Xiao ZD, Hung MC, Chen J, Huang P, Li W, Gan B. Nat Cell Biol. 2018 Oct;20(10):1181-1192. doi: 10.1038/s41556-018-0178-0. Epub 2018 Sep 10. PubMed

Associated Plasmids

Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma. McBrayer SK, Mayers JR, DiNatale GJ, Shi DD, Khanal J, Chakraborty AA, Sarosiek KA, Briggs KJ, Robbins AK, Sewastianik T, Shareef SJ, Olenchock BA, Parker SJ, Tateishi K, Spinelli JB, Islam M, Haigis MC, Looper RE, Ligon KL, Bernstein BE, Carrasco RD, Cahill DP, Asara JM, Metallo CM, Yennawar NH, Vander Heiden MG, Kaelin WG Jr. Cell. 2018 Sep 20;175(1):101-116.e25. doi: 10.1016/j.cell.2018.08.038. Epub 2018 Sep 13. PubMed
Ubiquitin ligase RNF8 suppresses Notch signaling to regulate mammary development and tumorigenesis. Li L, Guturi KKN, Gautreau B, Patel PS, Saad A, Morii M, Mateo F, Palomero L, Barbour H, Gomez A, Ng D, Kotlyar M, Pastrello C, Jackson HW, Khokha R, Jurisica I, Affar EB, Raught B, Sanchez O, Alaoui-Jamali M, Pujana MA, Hakem A, Hakem R. J Clin Invest. 2018 Oct 1;128(10):4525-4542. doi: 10.1172/JCI120401. Epub 2018 Aug 2. PubMed
Recurrent WNT pathway alterations are frequent in relapsed small cell lung cancer. Wagner AH, Devarakonda S, Skidmore ZL, Krysiak K, Ramu A, Trani L, Kunisaki J, Masood A, Waqar SN, Spies NC, Morgensztern D, Waligorski J, Ponce J, Fulton RS, Maggi LB Jr, Weber JD, Watson MA, O'Conor CJ, Ritter JH, Olsen RR, Cheng H, Mukhopadhyay A, Can I, Cessna MH, Oliver TG, Mardis ER, Wilson RK, Griffith M, Griffith OL, Govindan R. Nat Commun. 2018 Sep 17;9(1):3787. doi: 10.1038/s41467-018-06162-9. PubMed
A CRISPR screen identifies IFI6 as an ER-resident interferon effector that blocks flavivirus replication. Richardson RB, Ohlson MB, Eitson JL, Kumar A, McDougal MB, Boys IN, Mar KB, De La Cruz-Rivera PC, Douglas C, Konopka G, Xing C, Schoggins JW. Nat Microbiol. 2018 Nov;3(11):1214-1223. doi: 10.1038/s41564-018-0244-1. Epub 2018 Sep 17. PubMed
Functional Silencing of HSD17B2 in Prostate Cancer Promotes Disease Progression. Gao X, Dai C, Huang S, Tang J, Chen G, Li J, Zhu Z, Zhu X, Zhou S, Gao Y, Hou Z, Fang Z, Xu C, Wang J, Wu D, Sharifi N, Li Z. Clin Cancer Res. 2019 Feb 15;25(4):1291-1301. doi: 10.1158/1078-0432.CCR-18-2392. Epub 2018 Sep 18. PubMed
Systematic genetic mapping of necroptosis identifies SLC39A7 as modulator of death receptor trafficking. Fauster A, Rebsamen M, Willmann KL, Cesar-Razquin A, Girardi E, Bigenzahn JW, Schischlik F, Scorzoni S, Bruckner M, Konecka J, Hormann K, Heinz LX, Boztug K, Superti-Furga G. Cell Death Differ. 2018 Sep 20. pii: 10.1038/s41418-018-0192-6. doi: 10.1038/s41418-018-0192-6. PubMed
Biallelic mutations in human NHLRC2 enhance myofibroblast differentiation in FINCA disease. Paakkola T, Salokas K, Miinalainen I, Lehtonen S, Manninen A, Kaakinen M, Ruddock LW, Varjosalo M, Kaarteenaho R, Uusimaa J, Hinttala R. Hum Mol Genet. 2018 Dec 15;27(24):4288-4302. doi: 10.1093/hmg/ddy298. PubMed
Acetate Production from Glucose and Coupling to Mitochondrial Metabolism in Mammals. Liu X, Cooper DE, Cluntun AA, Warmoes MO, Zhao S, Reid MA, Liu J, Lund PJ, Lopes M, Garcia BA, Wellen KE, Kirsch DG, Locasale JW. Cell. 2018 Oct 4;175(2):502-513.e13. doi: 10.1016/j.cell.2018.08.040. Epub 2018 Sep 20. PubMed
Disruption of the superoxide anions-mitophagy regulation axis mediates copper oxide nanoparticles-induced vascular endothelial cell death. Zhang J, Wang B, Wang H, He H, Wu Q, Qin X, Yang X, Chen L, Xu G, Yuan Z, Yi Q, Zou Z, Yu C. Free Radic Biol Med. 2018 Dec;129:268-278. doi: 10.1016/j.freeradbiomed.2018.09.032. Epub 2018 Sep 21. PubMed
The cargo receptor SURF4 promotes the efficient cellular secretion of PCSK9. Emmer BT, Hesketh GG, Kotnik E, Tang VT, Lascuna PJ, Xiang J, Gingras AC, Chen XW, Ginsburg D. Elife. 2018 Sep 25;7. pii: 38839. doi: 10.7554/eLife.38839. PubMed
Loss of dihydrotestosterone-inactivation activity promotes prostate cancer castration resistance detectable by functional imaging. Zhu Z, Chung YM, Sergeeva O, Kepe V, Berk M, Li J, Ko HK, Li Z, Petro M, DiFilippo FP, Lee Z, Sharifi N. J Biol Chem. 2018 Nov 16;293(46):17829-17837. doi: 10.1074/jbc.RA118.004846. Epub 2018 Sep 27. PubMed
Infection-Induced Peroxisome Biogenesis Is a Metabolic Strategy for Herpesvirus Replication. Jean Beltran PM, Cook KC, Hashimoto Y, Galitzine C, Murray LA, Vitek O, Cristea IM. Cell Host Microbe. 2018 Oct 10;24(4):526-541.e7. doi: 10.1016/j.chom.2018.09.002. Epub 2018 Sep 27. PubMed
NONO Detects the Nuclear HIV Capsid to Promote cGAS-Mediated Innate Immune Activation. Lahaye X, Gentili M, Silvin A, Conrad C, Picard L, Jouve M, Zueva E, Maurin M, Nadalin F, Knott GJ, Zhao B, Du F, Rio M, Amiel J, Fox AH, Li P, Etienne L, Bond CS, Colleaux L, Manel N. Cell. 2018 Oct 4;175(2):488-501.e22. doi: 10.1016/j.cell.2018.08.062. Epub 2018 Sep 27. PubMed

Associated Plasmids

The DEAD-box RNA-binding protein DDX6 regulates parental RNA decay for cellular reprogramming to pluripotency. Kami D, Kitani T, Nakamura A, Wakui N, Mizutani R, Ohue M, Kametani F, Akimitsu N, Gojo S. PLoS One. 2018 Oct 1;13(10):e0203708. doi: 10.1371/journal.pone.0203708. eCollection 2018. PubMed
Role of PDGF receptor-alpha during human cytomegalovirus entry into fibroblasts. Wu K, Oberstein A, Wang W, Shenk T. Proc Natl Acad Sci U S A. 2018 Oct 16;115(42):E9889-E9898. doi: 10.1073/pnas.1806305115. Epub 2018 Oct 1. PubMed
Analysis of chromatin accessibility uncovers TEAD1 as a regulator of migration in human glioblastoma. Tome-Garcia J, Erfani P, Nudelman G, Tsankov AM, Katsyv I, Tejero R, Bin Zhang, Walsh M, Friedel RH, Zaslavsky E, Tsankova NM. Nat Commun. 2018 Oct 1;9(1):4020. doi: 10.1038/s41467-018-06258-2. PubMed
Membrane associated collagen XIII promotes cancer metastasis and enhances anoikis resistance. Zhang H, Fredericks T, Xiong G, Qi Y, Rychahou PG, Li JD, Pihlajaniemi T, Xu W, Xu R. Breast Cancer Res. 2018 Oct 1;20(1):116. doi: 10.1186/s13058-018-1030-y. PubMed
Targeting peroxiredoxin 1 impairs growth of breast cancer cells and potently sensitises these cells to prooxidant agents. Bajor M, Zych AO, Graczyk-Jarzynka A, Muchowicz A, Firczuk M, Trzeciak L, Gaj P, Domagala A, Siernicka M, Zagozdzon A, Siedlecki P, Kniotek M, O'Leary PC, Golab J, Zagozdzon R. Br J Cancer. 2018 Oct;119(7):873-884. doi: 10.1038/s41416-018-0263-y. Epub 2018 Oct 5. PubMed
Human genetic variation in GLS2 is associated with development of complicated Staphylococcus aureus bacteremia. Scott WK, Medie FM, Ruffin F, Sharma-Kuinkel BK, Cyr DD, Guo S, Dykxhoorn DM, Skov RL, Bruun NE, Dahl A, Lerche CJ, Petersen A, Larsen AR, Lauridsen TK, Johansen HK, Ullum H, Sorensen E, Hassager C, Bundgaard H, Schonheyder HC, Torp-Pedersen C, Ostergaard LB, Arpi M, Rosenvinge F, Erikstrup LT, Chehri M, Sogaard P, Andersen PS, Fowler VG Jr. PLoS Genet. 2018 Oct 5;14(10):e1007667. doi: 10.1371/journal.pgen.1007667. eCollection 2018 Oct. PubMed
Adducins inhibit lung cancer cell migration through mechanisms involving regulation of cell-matrix adhesion and cadherin-11 expression. Lechuga S, Amin PH, Wolen AR, Ivanov AI. Biochim Biophys Acta Mol Cell Res. 2019 Mar;1866(3):395-408. doi: 10.1016/j.bbamcr.2018.10.001. Epub 2018 Oct 2. PubMed
Exon Skipping in a Dysf-Missense Mutant Mouse Model. Malcher J, Heidt L, Goyenvalle A, Escobar H, Marg A, Beley C, Benchaouir R, Bader M, Spuler S, Garcia L, Schowel V. Mol Ther Nucleic Acids. 2018 Dec 7;13:198-207. doi: 10.1016/j.omtn.2018.08.013. Epub 2018 Aug 22. PubMed
Genetic Modulation of RNA Splicing with a CRISPR-Guided Cytidine Deaminase. Yuan J, Ma Y, Huang T, Chen Y, Peng Y, Li B, Li J, Zhang Y, Song B, Sun X, Ding Q, Song Y, Chang X. Mol Cell. 2018 Oct 18;72(2):380-394.e7. doi: 10.1016/j.molcel.2018.09.002. Epub 2018 Oct 4. PubMed
RAD9A promotes metastatic phenotypes through transcriptional regulation of anterior gradient 2 (AGR2). Broustas CG, Hopkins KM, Panigrahi SK, Wang L, Virk RK, Lieberman HB. Carcinogenesis. 2019 Mar 12;40(1):164-172. doi: 10.1093/carcin/bgy131. PubMed
A RECK-WNT7 Receptor-Ligand Interaction Enables Isoform-Specific Regulation of Wnt Bioavailability. Vallon M, Yuki K, Nguyen TD, Chang J, Yuan J, Siepe D, Miao Y, Essler M, Noda M, Garcia KC, Kuo CJ. Cell Rep. 2018 Oct 9;25(2):339-349.e9. doi: 10.1016/j.celrep.2018.09.045. PubMed
Long noncoding RNA C21orf121/bone morphogenetic protein 2/microRNA-140-5p gene network promotes directed differentiation of stem cells from human exfoliated deciduous teeth to neuronal cells. Liu J, Zhang ZY, Yu H, Yang AP, Hu PF, Liu Z, Wang M. J Cell Biochem. 2018 Oct 14. doi: 10.1002/jcb.27313. PubMed
Phosphorylation of TRIM28 Enhances the Expression of IFN-beta and Proinflammatory Cytokines During HPAIV Infection of Human Lung Epithelial Cells. Krischuns T, Gunl F, Henschel L, Binder M, Willemsen J, Schloer S, Rescher U, Gerlt V, Zimmer G, Nordhoff C, Ludwig S, Brunotte L. Front Immunol. 2018 Sep 28;9:2229. doi: 10.3389/fimmu.2018.02229. eCollection 2018. PubMed
Enzyme promiscuity drives branched-chain fatty acid synthesis in adipose tissues. Wallace M, Green CR, Roberts LS, Lee YM, McCarville JL, Sanchez-Gurmaches J, Meurs N, Gengatharan JM, Hover JD, Phillips SA, Ciaraldi TP, Guertin DA, Cabrales P, Ayres JS, Nomura DK, Loomba R, Metallo CM. Nat Chem Biol. 2018 Nov;14(11):1021-1031. doi: 10.1038/s41589-018-0132-2. Epub 2018 Oct 16. PubMed
The Lineage-Defining Transcription Factors SOX2 and NKX2-1 Determine Lung Cancer Cell Fate and Shape the Tumor Immune Microenvironment. Mollaoglu G, Jones A, Wait SJ, Mukhopadhyay A, Jeong S, Arya R, Camolotto SA, Mosbruger TL, Stubben CJ, Conley CJ, Bhutkar A, Vahrenkamp JM, Berrett KC, Cessna MH, Lane TE, Witt BL, Salama ME, Gertz J, Jones KB, Snyder EL, Oliver TG. Immunity. 2018 Oct 16;49(4):764-779.e9. doi: 10.1016/j.immuni.2018.09.020. PubMed

Associated Plasmids

PRMT6 Regulates RAS/RAF Binding and MEK/ERK-Mediated Cancer Stemness Activities in Hepatocellular Carcinoma through CRAF Methylation. Chan LH, Zhou L, Ng KY, Wong TL, Lee TK, Sharma R, Loong JH, Ching YP, Yuan YF, Xie D, Lo CM, Man K, Artegiani B, Clevers H, Yan HH, Leung SY, Richard S, Guan XY, Huen MSY, Ma S. Cell Rep. 2018 Oct 16;25(3):690-701.e8. doi: 10.1016/j.celrep.2018.09.053. PubMed
Transposon mutagenesis screen in mice identifies TM9SF2 as a novel colorectal cancer oncogene. Clark CR, Maile M, Blaney P, Hellweg SR, Strauss A, Durose W, Priya S, Habicht J, Burns MB, Blekhman R, Abrahante JE, Starr TK. Sci Rep. 2018 Oct 17;8(1):15327. doi: 10.1038/s41598-018-33527-3. PubMed
STIM2 interacts with AMPK and regulates calcium-induced AMPK activation. Chauhan AS, Liu X, Jing J, Lee H, Yadav RK, Liu J, Zhou Y, Gan B. FASEB J. 2019 Feb;33(2):2957-2970. doi: 10.1096/fj.201801225R. Epub 2018 Oct 18. PubMed
The Nedd8-activating enzyme inhibitor MLN4924 (TAK-924/Pevonedistat) induces apoptosis via c-Myc-Noxa axis in head and neck squamous cell carcinoma. Zhang W, Liang Y, Li L, Wang X, Yan Z, Dong C, Zeng MS, Zhong Q, Liu XK, Yu J, Sun S, Liu X, Kang J, Zhao H, Jeong LS, Zhang Y, Jia L. Cell Prolif. 2019 Mar;52(2):e12536. doi: 10.1111/cpr.12536. Epub 2018 Oct 19. PubMed
Dimerization of an aptamer generated from Ligand-guided selection (LIGS) yields a high affinity scaffold against B-cells. Batool S, Argyropoulos KV, Azad R, Okeoma P, Zumrut H, Bhandari S, Dekhang R, Mallikaratchy PR. Biochim Biophys Acta Gen Subj. 2019 Jan;1863(1):232-240. doi: 10.1016/j.bbagen.2018.10.006. Epub 2018 Oct 17. PubMed
Protein Barcodes Enable High-Dimensional Single-Cell CRISPR Screens. Wroblewska A, Dhainaut M, Ben-Zvi B, Rose SA, Park ES, Amir ED, Bektesevic A, Baccarini A, Merad M, Rahman AH, Brown BD. Cell. 2018 Nov 1;175(4):1141-1155.e16. doi: 10.1016/j.cell.2018.09.022. Epub 2018 Oct 18. PubMed
Cyclophilin J limits inflammation through the blockage of ubiquitin chain sensing. Sheng C, Yao C, Wang Z, Chen H, Zhao Y, Xu D, Huang H, Huang W, Chen S. Nat Commun. 2018 Oct 22;9(1):4381. doi: 10.1038/s41467-018-06756-3. PubMed
Monoubiquitination of ASXLs controls the deubiquitinase activity of the tumor suppressor BAP1. Daou S, Barbour H, Ahmed O, Masclef L, Baril C, Sen Nkwe N, Tchelougou D, Uriarte M, Bonneil E, Ceccarelli D, Mashtalir N, Tanji M, Masson JY, Thibault P, Sicheri F, Yang H, Carbone M, Therrien M, Affar EB. Nat Commun. 2018 Oct 22;9(1):4385. doi: 10.1038/s41467-018-06854-2. PubMed
Gene Disruption Using CRISPR-Cas9 Technology. Hu N, Malek SN. Methods Mol Biol. 2019;1881:201-209. doi: 10.1007/978-1-4939-8876-1_16. PubMed
INAVA-ARNO complexes bridge mucosal barrier function with inflammatory signaling. Luong P, Hedl M, Yan J, Zuo T, Fu TM, Jiang X, Thiagarajah JR, Hansen SH, Lesser CF, Wu H, Abraham C, Lencer WI. Elife. 2018 Oct 25;7. pii: 38539. doi: 10.7554/eLife.38539. PubMed
A peptide encoded by circular form of LINC-PINT suppresses oncogenic transcriptional elongation in glioblastoma. Zhang M, Zhao K, Xu X, Yang Y, Yan S, Wei P, Liu H, Xu J, Xiao F, Zhou H, Yang X, Huang N, Liu J, He K, Xie K, Zhang G, Huang S, Zhang N. Nat Commun. 2018 Oct 26;9(1):4475. doi: 10.1038/s41467-018-06862-2. PubMed
Identification of a cellularly active SIRT6 allosteric activator. Huang Z, Zhao J, Deng W, Chen Y, Shang J, Song K, Zhang L, Wang C, Lu S, Yang X, He B, Min J, Hu H, Tan M, Xu J, Zhang Q, Zhong J, Sun X, Mao Z, Lin H, Xiao M, Chin YE, Jiang H, Xu Y, Chen G, Zhang J. Nat Chem Biol. 2018 Dec;14(12):1118-1126. doi: 10.1038/s41589-018-0150-0. Epub 2018 Oct 29. PubMed
TXNDC9 promotes hepatocellular carcinoma progression by positive regulation of MYC-mediated transcriptional network. Chen D, Zou J, Zhao Z, Tang X, Deng Z, Jia J, Liu S. Cell Death Dis. 2018 Oct 31;9(11):1110. doi: 10.1038/s41419-018-1150-4. PubMed
Redox regulation of EGFR steers migration of hypoxic mammary cells towards oxygen. Deygas M, Gadet R, Gillet G, Rimokh R, Gonzalo P, Mikaelian I. Nat Commun. 2018 Oct 31;9(1):4545. doi: 10.1038/s41467-018-06988-3. PubMed
Targeting IFNalpha to tumor by anti-PD-L1 creates feedforward antitumor responses to overcome checkpoint blockade resistance. Liang Y, Tang H, Guo J, Qiu X, Yang Z, Ren Z, Sun Z, Bian Y, Xu L, Xu H, Shen J, Han Y, Dong H, Peng H, Fu YX. Nat Commun. 2018 Nov 2;9(1):4586. doi: 10.1038/s41467-018-06890-y. PubMed
N(6)-methyladenine DNA Modification in Glioblastoma. Xie Q, Wu TP, Gimple RC, Li Z, Prager BC, Wu Q, Yu Y, Wang P, Wang Y, Gorkin DU, Zhang C, Dowiak AV, Lin K, Zeng C, Sui Y, Kim LJY, Miller TE, Jiang L, Lee CH, Huang Z, Fang X, Zhai K, Mack SC, Sander M, Bao S, Kerstetter-Fogle AE, Sloan AE, Xiao AZ, Rich JN. Cell. 2018 Nov 15;175(5):1228-1243.e20. doi: 10.1016/j.cell.2018.10.006. Epub 2018 Nov 1. PubMed
Arginine starvation kills tumor cells through aspartate exhaustion and mitochondrial dysfunction. Cheng CT, Qi Y, Wang YC, Chi KK, Chung Y, Ouyang C, Chen YR, Oh ME, Sheng X, Tang Y, Liu YR, Lin HH, Kuo CY, Schones D, Vidal CM, Chu JC, Wang HJ, Chen YH, Miller KM, Chu P, Yen Y, Jiang L, Kung HJ, Ann DK. Commun Biol. 2018 Oct 26;1:178. doi: 10.1038/s42003-018-0178-4. eCollection 2018. PubMed
A Combination CDK4/6 and IGF1R Inhibitor Strategy for Ewing Sarcoma. Guenther LM, Dharia NV, Ross L, Conway A, Robichaud AL, Catlett JL 2nd, Wechsler CS, Frank ES, Goodale A, Church AJ, Tseng YY, Guha R, McKnight CG, Janeway KA, Boehm JS, Mora J, Davis MI, Alexe G, Piccioni F, Stegmaier K. Clin Cancer Res. 2019 Feb 15;25(4):1343-1357. doi: 10.1158/1078-0432.CCR-18-0372. Epub 2018 Nov 5. PubMed
Shiga Toxin/Lipopolysaccharide Activates Caspase-4 and Gasdermin D to Trigger Mitochondrial Reactive Oxygen Species Upstream of the NLRP3 Inflammasome. Platnich JM, Chung H, Lau A, Sandall CF, Bondzi-Simpson A, Chen HM, Komada T, Trotman-Grant AC, Brandelli JR, Chun J, Beck PL, Philpott DJ, Girardin SE, Ho M, Johnson RP, MacDonald JA, Armstrong GD, Muruve DA. Cell Rep. 2018 Nov 6;25(6):1525-1536.e7. doi: 10.1016/j.celrep.2018.09.071. PubMed
TET2 coactivates gene expression through demethylation of enhancers. Wang L, Ozark PA, Smith ER, Zhao Z, Marshall SA, Rendleman EJ, Piunti A, Ryan C, Whelan AL, Helmin KA, Morgan MA, Zou L, Singer BD, Shilatifard A. Sci Adv. 2018 Nov 7;4(11):eaau6986. doi: 10.1126/sciadv.aau6986. eCollection 2018 Nov. PubMed
Podoplanin expression is a prognostic biomarker but may be dispensable for the malignancy of glioblastoma. Eisemann T, Costa B, Harter PN, Wick W, Mittelbronn M, Angel P, Peterziel H. Neuro Oncol. 2018 Nov 10. pii: 5168873. doi: 10.1093/neuonc/noy184. PubMed
HIV-1 capsids from B27/B57+ elite controllers escape Mx2 but are targeted by TRIM5alpha, leading to the induction of an antiviral state. Merindol N, El-Far M, Sylla M, Masroori N, Dufour C, Li JX, Cherry P, Plourde MB, Tremblay C, Berthoux L. PLoS Pathog. 2018 Nov 12;14(11):e1007398. doi: 10.1371/journal.ppat.1007398. eCollection 2018 Nov. PubMed
LAT2 regulates glutamine-dependent mTOR activation to promote glycolysis and chemoresistance in pancreatic cancer. Feng M, Xiong G, Cao Z, Yang G, Zheng S, Qiu J, You L, Zheng L, Zhang T, Zhao Y. J Exp Clin Cancer Res. 2018 Nov 12;37(1):274. doi: 10.1186/s13046-018-0947-4. PubMed
Defective DNA damage repair leads to frequent catastrophic genomic events in murine and human tumors. Ratnaparkhe M, Wong JKL, Wei PC, Hlevnjak M, Kolb T, Simovic M, Haag D, Paul Y, Devens F, Northcott P, Jones DTW, Kool M, Jauch A, Pastorczak A, Mlynarski W, Korshunov A, Kumar R, Downing SM, Pfister SM, Zapatka M, McKinnon PJ, Alt FW, Lichter P, Ernst A. Nat Commun. 2018 Nov 12;9(1):4760. doi: 10.1038/s41467-018-06925-4. PubMed
Epstein-Barr virus BORF2 inhibits cellular APOBEC3B to preserve viral genome integrity. Cheng AZ, Yockteng-Melgar J, Jarvis MC, Malik-Soni N, Borozan I, Carpenter MA, McCann JL, Ebrahimi D, Shaban NM, Marcon E, Greenblatt J, Brown WL, Frappier L, Harris RS. Nat Microbiol. 2019 Jan;4(1):78-88. doi: 10.1038/s41564-018-0284-6. Epub 2018 Nov 12. PubMed
Targeting MYC dependency in ovarian cancer through inhibition of CDK7 and CDK12/13. Zeng M, Kwiatkowski NP, Zhang T, Nabet B, Xu M, Liang Y, Quan C, Wang J, Hao M, Palakurthi S, Zhou S, Zeng Q, Kirschmeier PT, Meghani K, Leggett AL, Qi J, Shapiro GI, Liu JF, Matulonis UA, Lin CY, Konstantinopoulos PA, Gray NS. Elife. 2018 Nov 13;7. pii: 39030. doi: 10.7554/eLife.39030. PubMed
FLI1 Exonic Circular RNAs as a Novel Oncogenic Driver to Promote Tumor Metastasis in Small Cell Lung Cancer. Li L, Li W, Chen N, Zhao H, Xu G, Zhao Y, Pan X, Zhang X, Zhou L, Yu D, Li A, Hu JF, Cui J. Clin Cancer Res. 2019 Feb 15;25(4):1302-1317. doi: 10.1158/1078-0432.CCR-18-1447. Epub 2018 Nov 14. PubMed
A conserved enhancer regulates Il9 expression in multiple lineages. Koh B, Abdul Qayum A, Srivastava R, Fu Y, Ulrich BJ, Janga SC, Kaplan MH. Nat Commun. 2018 Nov 15;9(1):4803. doi: 10.1038/s41467-018-07202-0. PubMed
A hPSC-based platform to discover gene-environment interactions that impact human beta-cell and dopamine neuron survival. Zhou T, Kim TW, Chong CN, Tan L, Amin S, Sadat Badieyan Z, Mukherjee S, Ghazizadeh Z, Zeng H, Guo M, Crespo M, Zhang T, Kenyon R, Robinson CL, Apostolou E, Wang H, Xiang JZ, Evans T, Studer L, Chen S. Nat Commun. 2018 Nov 16;9(1):4815. doi: 10.1038/s41467-018-07201-1. PubMed
NUAK2 is a critical YAP target in liver cancer. Yuan WC, Pepe-Mooney B, Galli GG, Dill MT, Huang HT, Hao M, Wang Y, Liang H, Calogero RA, Camargo FD. Nat Commun. 2018 Nov 16;9(1):4834. doi: 10.1038/s41467-018-07394-5. PubMed
Unique, Intersecting, and Overlapping Roles of C/EBP beta and CREB in Cells of the Innate Immune System. Larabee JL, Hauck G, Ballard JD. Sci Rep. 2018 Nov 16;8(1):16931. doi: 10.1038/s41598-018-35184-y. PubMed
Mitochondria-Derived Vesicles Deliver Antimicrobial Reactive Oxygen Species to Control Phagosome-Localized Staphylococcus aureus. Abuaita BH, Schultz TL, O'Riordan MX. Cell Host Microbe. 2018 Nov 14;24(5):625-636.e5. doi: 10.1016/j.chom.2018.10.005. Epub 2018 Oct 25. PubMed
Alarmin S100A11 initiates a chemokine response to the human pathogen Toxoplasma gondii. Safronova A, Araujo A, Camanzo ET, Moon TJ, Elliott MR, Beiting DP, Yarovinsky F. Nat Immunol. 2019 Jan;20(1):64-72. doi: 10.1038/s41590-018-0250-8. Epub 2018 Nov 19. PubMed
Transmembrane Protease TMPRSS11B Promotes Lung Cancer Growth by Enhancing Lactate Export and Glycolytic Metabolism. Updegraff BL, Zhou X, Guo Y, Padanad MS, Chen PH, Yang C, Sudderth J, Rodriguez-Tirado C, Girard L, Minna JD, Mishra P, DeBerardinis RJ, O'Donnell KA. Cell Rep. 2018 Nov 20;25(8):2223-2233.e6. doi: 10.1016/j.celrep.2018.10.100. PubMed
RNA Helicase A Is an Important Host Factor Involved in Dengue Virus Replication. Wang Y, Chen X, Xie J, Zhou S, Huang Y, Li YP, Li X, Liu C, He J, Zhang P. J Virol. 2019 Feb 5;93(4). pii: JVI.01306-18. doi: 10.1128/JVI.01306-18. Print 2019 Feb 15. PubMed
Protocadherin-1 is essential for cell entry by New World hantaviruses. Jangra RK, Herbert AS, Li R, Jae LT, Kleinfelter LM, Slough MM, Barker SL, Guardado-Calvo P, Roman-Sosa G, Dieterle ME, Kuehne AI, Muena NA, Wirchnianski AS, Nyakatura EK, Fels JM, Ng M, Mittler E, Pan J, Bharrhan S, Wec AZ, Lai JR, Sidhu SS, Tischler ND, Rey FA, Moffat J, Brummelkamp TR, Wang Z, Dye JM, Chandran K. Nature. 2018 Nov;563(7732):559-563. doi: 10.1038/s41586-018-0702-1. Epub 2018 Nov 21. PubMed
Mannose impairs tumour growth and enhances chemotherapy. Gonzalez PS, O'Prey J, Cardaci S, Barthet VJA, Sakamaki JI, Beaumatin F, Roseweir A, Gay DM, Mackay G, Malviya G, Kania E, Ritchie S, Baudot AD, Zunino B, Mrowinska A, Nixon C, Ennis D, Hoyle A, Millan D, McNeish IA, Sansom OJ, Edwards J, Ryan KM. Nature. 2018 Nov;563(7733):719-723. doi: 10.1038/s41586-018-0729-3. Epub 2018 Nov 21. PubMed
ATRX promotes maintenance of herpes simplex virus heterochromatin during chromatin stress. Cabral JM, Oh HS, Knipe DM. Elife. 2018 Nov 22;7. pii: 40228. doi: 10.7554/eLife.40228. PubMed
Interactome and Proteome Dynamics Uncover Immune Modulatory Associations of the Pathogen Sensing Factor cGAS. Lum KK, Song B, Federspiel JD, Diner BA, Howard T, Cristea IM. Cell Syst. 2018 Dec 26;7(6):627-642.e6. doi: 10.1016/j.cels.2018.10.010. Epub 2018 Nov 21. PubMed
RORalpha controls inflammatory state of human macrophages. Nejati Moharrami N, Bjorkoy Tande E, Ryan L, Espevik T, Boyartchuk V. PLoS One. 2018 Nov 28;13(11):e0207374. doi: 10.1371/journal.pone.0207374. eCollection 2018. PubMed
Human Leukocyte Antigen Class I and II Knockout Human Induced Pluripotent Stem Cell-Derived Cells: Universal Donor for Cell Therapy. Mattapally S, Pawlik KM, Fast VG, Zumaquero E, Lund FE, Randall TD, Townes TM, Zhang J. J Am Heart Assoc. 2018 Dec 4;7(23):e010239. doi: 10.1161/JAHA.118.010239. PubMed
Mutant p53s generate pro-invasive niches by influencing exosome podocalyxin levels. Novo D, Heath N, Mitchell L, Caligiuri G, MacFarlane A, Reijmer D, Charlton L, Knight J, Calka M, McGhee E, Dornier E, Sumpton D, Mason S, Echard A, Klinkert K, Secklehner J, Kruiswijk F, Vousden K, Macpherson IR, Blyth K, Bailey P, Yin H, Carlin LM, Morton J, Zanivan S, Norman JC. Nat Commun. 2018 Nov 29;9(1):5069. doi: 10.1038/s41467-018-07339-y. PubMed
Rejection of immunogenic tumor clones is limited by clonal fraction. Gejman RS, Chang AY, Jones HF, DiKun K, Hakimi AA, Schietinger A, Scheinberg DA. Elife. 2018 Nov 30;7. pii: 41090. doi: 10.7554/eLife.41090. PubMed

Associated Plasmids

Asymmetric dimethylation at histone H3 arginine 2 by PRMT6 in gastric cancer progression. Okuno K, Akiyama Y, Shimada S, Nakagawa M, Tanioka T, Inokuchi M, Yamaoka S, Kojima K, Tanaka S. Carcinogenesis. 2019 Mar 12;40(1):15-26. doi: 10.1093/carcin/bgy147. PubMed
Histone demethylase KDM3B regulates the transcriptional network of cell-cycle genes in hepatocarcinoma HepG2 cells. An MJ, Kim DH, Kim CH, Kim M, Rhee S, Seo SB, Kim JW. Biochem Biophys Res Commun. 2019 Jan 8;508(2):576-582. doi: 10.1016/j.bbrc.2018.11.179. Epub 2018 Dec 1. PubMed
GSK3 suppression upregulates beta-catenin and c-Myc to abrogate KRas-dependent tumors. Kazi A, Xiang S, Yang H, Delitto D, Trevino J, Jiang RHY, Ayaz M, Lawrence HR, Kennedy P, Sebti SM. Nat Commun. 2018 Dec 4;9(1):5154. doi: 10.1038/s41467-018-07644-6. PubMed
Polycomb- and Methylation-Independent Roles of EZH2 as a Transcription Activator. Kim J, Lee Y, Lu X, Song B, Fong KW, Cao Q, Licht JD, Zhao JC, Yu J. Cell Rep. 2018 Dec 4;25(10):2808-2820.e4. doi: 10.1016/j.celrep.2018.11.035. PubMed
A virus-packageable CRISPR screen identifies host factors mediating interferon inhibition of HIV. OhAinle M, Helms L, Vermeire J, Roesch F, Humes D, Basom R, Delrow JJ, Overbaugh J, Emerman M. Elife. 2018 Dec 6;7. pii: 39823. doi: 10.7554/eLife.39823. PubMed
Interferons Transcriptionally Up-Regulate MLKL Expression in Cancer Cells. Knuth AK, Rosler S, Schenk B, Kowald L, van Wijk SJL, Fulda S. Neoplasia. 2019 Jan;21(1):74-81. doi: 10.1016/j.neo.2018.11.002. Epub 2018 Dec 3. PubMed
Functional genomic characterization of a synthetic anti-HER3 antibody reveals a role for ubiquitination by RNF41 in the anti-proliferative response. Turowec JP, Lau EWT, Wang X, Brown KR, Fellouse FA, Jawanda KK, Pan J, Moffat J, Sidhu SS. J Biol Chem. 2019 Jan 25;294(4):1396-1409. doi: 10.1074/jbc.RA118.004420. Epub 2018 Dec 6. PubMed
An inflammatory-CCRK circuitry drives mTORC1-dependent metabolic and immunosuppressive reprogramming in obesity-associated hepatocellular carcinoma. Sun H, Yang W, Tian Y, Zeng X, Zhou J, Mok MTS, Tang W, Feng Y, Xu L, Chan AWH, Tong JH, Cheung YS, Lai PBS, Wang HKS, Tsang SW, Chow KL, Hu M, Liu R, Huang L, Yang B, Yang P, To KF, Sung JJY, Wong GLH, Wong VWS, Cheng ASL. Nat Commun. 2018 Dec 6;9(1):5214. doi: 10.1038/s41467-018-07402-8. PubMed
Inhibition of Membrane-Bound BAFF by the Anti-BAFF Antibody Belimumab. Kowalczyk-Quintas C, Chevalley D, Willen L, Jandus C, Vigolo M, Schneider P. Front Immunol. 2018 Nov 20;9:2698. doi: 10.3389/fimmu.2018.02698. eCollection 2018. PubMed
High-performance gene expression and knockout tools using sleeping beauty transposon system. Hu K, Li Y, Wu W, Chen H, Chen Z, Zhang Y, Guo Y, Dong Y. Mob DNA. 2018 Nov 26;9:33. doi: 10.1186/s13100-018-0139-y. eCollection 2018. PubMed
Cytidine deaminase enables Toll-like receptor 8 activation by cytidine or its analogs. Furusho K, Shibata T, Sato R, Fukui R, Motoi Y, Zhang Y, Saitoh SI, Ichinohe T, Moriyama M, Nakamura S, Miyake K. Int Immunol. 2018 Dec 10. pii: 5237423. doi: 10.1093/intimm/dxy075. PubMed
Application of Mito-Priming to Generate BCL-2 Addicted Cells. Lopez J, Tait SWG. Methods Mol Biol. 2019;1877:45-60. doi: 10.1007/978-1-4939-8861-7_3. PubMed
Loss of the FAT1 Tumor Suppressor Promotes Resistance to CDK4/6 Inhibitors via the Hippo Pathway. Li Z, Razavi P, Li Q, Toy W, Liu B, Ping C, Hsieh W, Sanchez-Vega F, Brown DN, Da Cruz Paula AF, Morris L, Selenica P, Eichenberger E, Shen R, Schultz N, Rosen N, Scaltriti M, Brogi E, Baselga J, Reis-Filho JS, Chandarlapaty S. Cancer Cell. 2018 Dec 10;34(6):893-905.e8. doi: 10.1016/j.ccell.2018.11.006. PubMed
Identification and Characterization of Synthetic Viability with ERCC1 Deficiency in Response to Interstrand Crosslinks in Lung Cancer. Heyza JR, Lei W, Watza D, Zhang H, Chen W, Back JB, Schwartz AG, Bepler G, Patrick SM. Clin Cancer Res. 2018 Dec 11. pii: 1078-0432.CCR-18-3094. doi: 10.1158/1078-0432.CCR-18-3094. PubMed
O-GlcNAc Transferase Links Glucose Metabolism to MAVS-Mediated Antiviral Innate Immunity. Li T, Li X, Attri KS, Liu C, Li L, Herring LE, Asara JM, Lei YL, Singh PK, Gao C, Wen H. Cell Host Microbe. 2018 Dec 12;24(6):791-803.e6. doi: 10.1016/j.chom.2018.11.001. PubMed
Neuron-specific signatures in the chromosomal connectome associated with schizophrenia risk. Rajarajan P, Borrman T, Liao W, Schrode N, Flaherty E, Casino C, Powell S, Yashaswini C, LaMarca EA, Kassim B, Javidfar B, Espeso-Gil S, Li A, Won H, Geschwind DH, Ho SM, MacDonald M, Hoffman GE, Roussos P, Zhang B, Hahn CG, Weng Z, Brennand KJ, Akbarian S. Science. 2018 Dec 14;362(6420). pii: 362/6420/eaat4311. doi: 10.1126/science.aat4311. PubMed
CRISPR-C: circularization of genes and chromosome by CRISPR in human cells. Moller HD, Lin L, Xiang X, Petersen TS, Huang J, Yang L, Kjeldsen E, Jensen UB, Zhang X, Liu X, Xu X, Wang J, Yang H, Church GM, Bolund L, Regenberg B, Luo Y. Nucleic Acids Res. 2018 Dec 14;46(22):e131. doi: 10.1093/nar/gky767. PubMed
Loss of KDM6A characterizes a poor prognostic subtype of human pancreatic cancer and potentiates HDAC inhibitor lethality. Watanabe S, Shimada S, Akiyama Y, Ishikawa Y, Ogura T, Ogawa K, Ono H, Mitsunori Y, Ban D, Kudo A, Yamaoka S, Tanabe M, Tanaka S. Int J Cancer. 2018 Dec 17. doi: 10.1002/ijc.32072. PubMed
The ASCIZ-DYNLL1 axis promotes 53BP1-dependent non-homologous end joining and PARP inhibitor sensitivity. Becker JR, Cuella-Martin R, Barazas M, Liu R, Oliveira C, Oliver AW, Bilham K, Holt AB, Blackford AN, Heierhorst J, Jonkers J, Rottenberg S, Chapman JR. Nat Commun. 2018 Dec 17;9(1):5406. doi: 10.1038/s41467-018-07855-x. PubMed
Proteasomal degradation of NOD2 by NLRP12 in monocytes promotes bacterial tolerance and colonization by enteropathogens. Normand S, Waldschmitt N, Neerincx A, Martinez-Torres RJ, Chauvin C, Couturier-Maillard A, Boulard O, Cobret L, Awad F, Huot L, Ribeiro-Ribeiro A, Lautz K, Ruez R, Delacre M, Bondu C, Guilliams M, Scott C, Segal A, Amselem S, Hot D, Karabina S, Bohn E, Ryffel B, Poulin LF, Kufer TA, Chamaillard M. Nat Commun. 2018 Dec 17;9(1):5338. doi: 10.1038/s41467-018-07750-5. PubMed
CRISPR-Mediated Approaches to Regulate YAP/TAZ Levels. Quinton RJ, Ganem NJ. Methods Mol Biol. 2019;1893:203-214. doi: 10.1007/978-1-4939-8910-2_16. PubMed
Polarization of Human Macrophages by Interleukin-4 Does Not Require ATP-Citrate Lyase. Namgaladze D, Zukunft S, Schnutgen F, Kurrle N, Fleming I, Fuhrmann D, Brune B. Front Immunol. 2018 Dec 4;9:2858. doi: 10.3389/fimmu.2018.02858. eCollection 2018. PubMed
Regulation of mitochondrial iron homeostasis by sideroflexin 2. Mon EE, Wei FY, Ahmad RNR, Yamamoto T, Moroishi T, Tomizawa K. J Physiol Sci. 2019 Mar;69(2):359-373. doi: 10.1007/s12576-018-0652-2. Epub 2018 Dec 20. PubMed
High cortactin expression in B-cell acute lymphoblastic leukemia is associated with increased transendothelial migration and bone marrow relapse. Velazquez-Avila M, Balandran JC, Ramirez-Ramirez D, Velazquez-Avila M, Sandoval A, Felipe-Lopez A, Nava P, Alvarado-Moreno JA, Dozal D, Prieto-Chavez JL, Schaks M, Rottner K, Dorantes-Acosta E, Lopez-Martinez B, Schnoor M, Pelayo R. Leukemia. 2018 Dec 20. pii: 10.1038/s41375-018-0333-4. doi: 10.1038/s41375-018-0333-4. PubMed
A miR-150/TET3 pathway regulates the generation of mouse and human non-classical monocyte subset. Selimoglu-Buet D, Riviere J, Ghamlouch H, Bencheikh L, Lacout C, Morabito M, Diop M, Meurice G, Breckler M, Chauveau A, Debord C, Debeurme F, Itzykson R, Chapuis N, Willekens C, Wagner-Ballon O, Bernard OA, Droin N, Solary E. Nat Commun. 2018 Dec 21;9(1):5455. doi: 10.1038/s41467-018-07801-x. PubMed
Optimized libraries for CRISPR-Cas9 genetic screens with multiple modalities. Sanson KR, Hanna RE, Hegde M, Donovan KF, Strand C, Sullender ME, Vaimberg EW, Goodale A, Root DE, Piccioni F, Doench JG. Nat Commun. 2018 Dec 21;9(1):5416. doi: 10.1038/s41467-018-07901-8. PubMed

Associated Plasmids

p62/SQSTM1 Fuels Melanoma Progression by Opposing mRNA Decay of a Selective Set of Pro-metastatic Factors. Karras P, Riveiro-Falkenbach E, Canon E, Tejedo C, Calvo TG, Martinez-Herranz R, Alonso-Curbelo D, Cifdaloz M, Perez-Guijarro E, Gomez-Lopez G, Ximenez-Embun P, Munoz J, Megias D, Olmeda D, Moscat J, Ortiz-Romero PL, Rodriguez-Peralto JL, Soengas MS. Cancer Cell. 2019 Jan 14;35(1):46-63.e10. doi: 10.1016/j.ccell.2018.11.008. Epub 2018 Dec 20. PubMed
Preclinical Development of Bivalent Chimeric Antigen Receptors Targeting Both CD19 and CD22. Qin H, Ramakrishna S, Nguyen S, Fountaine TJ, Ponduri A, Stetler-Stevenson M, Yuan CM, Haso W, Shern JF, Shah NN, Fry TJ. Mol Ther Oncolytics. 2018 Nov 6;11:127-137. doi: 10.1016/j.omto.2018.10.006. eCollection 2018 Dec 21. PubMed
The Interaction between Laminin-332 and alpha3beta1 Integrin Determines Differentiation and Maintenance of CAFs, and Supports Invasion of Pancreatic Duct Adenocarcinoma Cells. Cavaco ACM, Rezaei M, Caliandro MF, Lima AM, Stehling M, Dhayat SA, Haier J, Brakebusch C, Eble JA. Cancers (Basel). 2018 Dec 21;11(1). pii: cancers11010014. doi: 10.3390/cancers11010014. PubMed
Replisome Dynamics and Their Functional Relevance upon DNA Damage through the PCNA Interactome. Srivastava M, Chen Z, Zhang H, Tang M, Wang C, Jung SY, Chen J. Cell Rep. 2018 Dec 26;25(13):3869-3883.e4. doi: 10.1016/j.celrep.2018.11.099. PubMed
Inhibition of XPO1 enhances cell death induced by ABT-199 in acute myeloid leukaemia via Mcl-1. Luedtke DA, Su Y, Liu S, Edwards H, Wang Y, Lin H, Taub JW, Ge Y. J Cell Mol Med. 2018 Dec;22(12):6099-6111. doi: 10.1111/jcmm.13886. Epub 2018 Sep 14. PubMed
APIM-Mediated REV3L(-)PCNA Interaction Important for Error Free TLS Over UV-Induced DNA Lesions in Human Cells. Raeder SB, Nepal A, Bjoras KO, Seelinger M, Kolve RS, Nedal A, Muller R, Otterlei M. Int J Mol Sci. 2018 Dec 28;20(1). pii: ijms20010100. doi: 10.3390/ijms20010100. PubMed
SG formation relies on eIF4GI-G3BP interaction which is targeted by picornavirus stress antagonists. Yang X, Hu Z, Zhang Q, Fan S, Zhong Y, Guo D, Qin Y, Chen M. Cell Discov. 2019 Jan 1;5:1. doi: 10.1038/s41421-018-0068-4. eCollection 2019. PubMed
Targeting B7-H1 (PD-L1) sensitizes cancer cells to chemotherapy. Wu X, Li Y, Liu X, Chen C, Harrington SM, Cao S, Xie T, Orzechowski A, Pham T, Mansfield AS, Yan Y, Kwon ED, Wang L, Ling K, Dong H. Heliyon. 2018 Dec 18;4(12):e01039. doi: 10.1016/j.heliyon.2018.e01039. eCollection 2018 Dec. PubMed