pMD2.G Citations (6239)
Originally described in: Trono Lab Packaging and Envelope PlasmidsUnpublished
Articles Citing pMD2.G
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| New cell lines from mouse epiblast share defining features with human embryonic stem cells. Tesar PJ, Chenoweth JG, Brook FA, Davies TJ, Evans EP, Mack DL, Gardner RL, McKay RD. Nature. 2007 Jul 12. 448(7150):196-9. PubMed |
| Determination of the transforming activities of adenovirus oncogenes. Nevels M, Dobner T. Methods Mol Med. 2007;131:187-95. PubMed |
| Up-regulation of c-FLIP short by NFAT contributes to apoptosis resistance of short-term activated T cells. Ueffing N, Schuster M, Keil E, Schulze-Osthoff K, Schmitz I. Blood. 2008 Aug 1;112(3):690-8. doi: 10.1182/blood-2008-02-141382. Epub 2008 May 28. PubMed |
| CCL2 protects prostate cancer PC3 cells from autophagic death via phosphatidylinositol 3-kinase/AKT-dependent survivin up-regulation. Roca H, Varsos Z, Pienta KJ. J Biol Chem. 2008 Sep 5;283(36):25057-73. doi: 10.1074/jbc.M801073200. Epub 2008 Jul 8. PubMed |
| Feeder-free culture of human embryonic stem cells in conditioned medium for efficient genetic modification. Braam SR, Denning C, Matsa E, Young LE, Passier R, Mummery CL. Nat Protoc. 2008;3(9):1435-43. doi: 10.1038/nprot.2008.140. PubMed |
| The scaffold protein JSAP1 regulates proliferation and differentiation of cerebellar granule cell precursors by modulating JNK signaling. Sato T, Torashima T, Sugihara K, Hirai H, Asano M, Yoshioka K. Mol Cell Neurosci. 2008 Dec;39(4):569-78. doi: 10.1016/j.mcn.2008.08.003. Epub 2008 Aug 30. PubMed |
| Functional involvement of RINF, retinoid-inducible nuclear factor (CXXC5), in normal and tumoral human myelopoiesis. Pendino F, Nguyen E, Jonassen I, Dysvik B, Azouz A, Lanotte M, Segal-Bendirdjian E, Lillehaug JR. Blood. 2009 Apr 2;113(14):3172-81. doi: 10.1182/blood-2008-07-170035. Epub 2009 Jan 30. PubMed |
| A functional genomic screen identifies cellular cofactors of hepatitis C virus replication. Tai AW, Benita Y, Peng LF, Kim SS, Sakamoto N, Xavier RJ, Chung RT. Cell Host Microbe. 2009 Mar 19;5(3):298-307. doi: 10.1016/j.chom.2009.02.001. PubMed |
| In vitro and in vivo validation of human and goat chondrocyte labeling by green fluorescent protein lentivirus transduction. Miot S, Gianni-Barrera R, Pelttari K, Acharya C, Mainil-Varlet P, Juelke H, Jaquiery C, Candrian C, Barbero A, Martin I. Tissue Eng Part C Methods. 2010 Feb;16(1):11-21. doi: 10.1089/ten.TEC.2008.0698. PubMed |
| TNFAIP3 (A20) is a tumor suppressor gene in Hodgkin lymphoma and primary mediastinal B cell lymphoma. Schmitz R, Hansmann ML, Bohle V, Martin-Subero JI, Hartmann S, Mechtersheimer G, Klapper W, Vater I, Giefing M, Gesk S, Stanelle J, Siebert R, Kuppers R. J Exp Med. 2009 May 11;206(5):981-9. doi: 10.1084/jem.20090528. Epub 2009 Apr 20. PubMed |
| Tumor microvasculature supports proliferation and expansion of glioma-propagating cells. Borovski T, Verhoeff JJ, ten Cate R, Cameron K, de Vries NA, van Tellingen O, Richel DJ, van Furth WR, Medema JP, Sprick MR. Int J Cancer. 2009 Sep 1;125(5):1222-30. doi: 10.1002/ijc.24408. PubMed |
| Molecular dissection of the ILK-PINCH-parvin triad reveals a fundamental role for the ILK kinase domain in the late stages of focal-adhesion maturation. Stanchi F, Grashoff C, Nguemeni Yonga CF, Grall D, Fassler R, Van Obberghen-Schilling E. J Cell Sci. 2009 Jun 1;122(Pt 11):1800-11. doi: 10.1242/jcs.044602. Epub 2009 May 12. PubMed |
| In vivo genetic manipulation of the rat trophoblast cell lineage using lentiviral vector delivery. Lee DS, Rumi MA, Konno T, Soares MJ. Genesis. 2009 Jul;47(7):433-9. doi: 10.1002/dvg.20518. PubMed |
| Sequential cooperation of CD2 and CD48 in the buildup of the early TCR signalosome. Muhammad A, Schiller HB, Forster F, Eckerstorfer P, Geyeregger R, Leksa V, Zlabinger GJ, Sibilia M, Sonnleitner A, Paster W, Stockinger H. J Immunol. 2009 Jun 15;182(12):7672-80. doi: 10.4049/jimmunol.0800691. PubMed |
| Tubulin polymerization-promoting protein (TPPP/p25) is critical for oligodendrocyte differentiation. Lehotzky A, Lau P, Tokesi N, Muja N, Hudson LD, Ovadi J. Glia. 2010 Jan 15;58(2):157-68. doi: 10.1002/glia.20909. PubMed |
| Long term non-invasive imaging of embryonic stem cells using reporter genes. Sun N, Lee A, Wu JC. Nat Protoc. 2009;4(8):1192-201. doi: 10.1038/nprot.2009.100. Epub 2009 Jul 23. PubMed |
| Transforming growth-interacting factor (TGIF) regulates proliferation and differentiation of human myeloid leukemia cells. Hamid R, Brandt SJ. Mol Oncol. 2009 Dec;3(5-6):451-63. doi: 10.1016/j.molonc.2009.07.004. Epub 2009 Jul 29. PubMed |
| Variegation and silencing in a lentiviral-based murine transgenic model. Baup D, Fraga L, Pernot E, Van Acker A, Vanherck AS, Breckpot K, Thielemans K, Schurmans S, Moser M, Leo O. Transgenic Res. 2010 Jun;19(3):399-414. doi: 10.1007/s11248-009-9318-4. Epub 2009 Aug 23. PubMed |
| Multipurpose modular lentiviral vectors for RNA interference and transgene expression. Kesireddy V, van der Ven PF, Furst DO. Mol Biol Rep. 2010 Jul;37(6):2863-70. doi: 10.1007/s11033-009-9840-8. Epub 2009 Oct 2. PubMed |
| Amyotrophic lateral sclerosis-linked mutant SOD1 sequesters Hu antigen R (HuR) and TIA-1-related protein (TIAR): implications for impaired post-transcriptional regulation of vascular endothelial growth factor. Lu L, Wang S, Zheng L, Li X, Suswam EA, Zhang X, Wheeler CG, Nabors LB, Filippova N, King PH. J Biol Chem. 2009 Dec 4. 284(49):33989-98. PubMed |
| Developmental regulation of the composite CAG promoter activity in the murine T lymphocyte cell lineage. Baup D, Moser M, Schurmans S, Leo O. Genesis. 2009 Dec;47(12):799-804. doi: 10.1002/dvg.20569. PubMed |
| Inducible APOBEC3G-Vif double stable cell line as a high-throughput screening platform to identify antiviral compounds. Nowotny B, Schneider T, Pradel G, Schirmeister T, Rethwilm A, Kirschner M. Antimicrob Agents Chemother. 2010 Jan;54(1):78-87. doi: 10.1128/AAC.00775-09. Epub 2009 Oct 19. PubMed |
| Reversibly immortalized human olfactory ensheathing glia from an elderly donor maintain neuroregenerative capacity. Lim F, Martin-Bermejo MJ, Garcia-Escudero V, Gallego-Hernandez MT, Garcia-Gomez A, Rabano A, Diaz-Nido J, Avila J, Moreno-Flores MT. Glia. 2010 Apr;58(5):546-58. doi: 10.1002/glia.20944. PubMed |
| Transcription factors RUNX1 and RUNX3 in the induction and suppressive function of Foxp3+ inducible regulatory T cells. Klunker S, Chong MM, Mantel PY, Palomares O, Bassin C, Ziegler M, Ruckert B, Meiler F, Akdis M, Littman DR, Akdis CA. J Exp Med. 2009 Nov 23;206(12):2701-15. doi: 10.1084/jem.20090596. Epub 2009 Nov 16. PubMed |
| Prevention of senescence progression in reversibly immortalized human ensheathing glia permits their survival after deimmortalization. García-Escudero V, García-Gómez A, Gargini R, Martín-Bermejo MJ, Langa E, de Yébenes JG, Delicado A, Avila J, Moreno-Flores MT, Lim F. Mol Ther. 2010 Feb . 18(2):394-403. PubMed |
| Cocal-pseudotyped lentiviral vectors resist inactivation by human serum and efficiently transduce primate hematopoietic repopulating cells. Trobridge GD, Wu RA, Hansen M, Ironside C, Watts KL, Olsen P, Beard BC, Kiem HP. Mol Ther. 2010 Apr;18(4):725-33. doi: 10.1038/mt.2009.282. Epub 2009 Dec 8. PubMed |
| Lentiviral gene transduction in human and mouse NK cell lines. Savan R, Chan T, Young HA. Methods Mol Biol. 2010;612:209-21. doi: 10.1007/978-1-60761-362-6_14. PubMed |
| HEF1 is a crucial mediator of the proliferative effects of prostaglandin E(2) on colon cancer cells. Xia D, Holla VR, Wang D, Menter DG, DuBois RN. Cancer Res. 2010 Jan 15;70(2):824-31. doi: 10.1158/0008-5472.CAN-09-2105. Epub 2010 Jan 12. PubMed |
Gateway-compatible lentiviral transfer vectors for ubiquitin promoter driven expression of fluorescent fusion proteins.
Krupka N, Strappe P, Gotz J, Ittner LM.
Plasmid. 2010 May;63(3):155-60. doi: 10.1016/j.plasmid.2010.01.002. Epub 2010 Feb 2.
PubMed
Associated Plasmids |
| An inducible Tet-Off-H2B-GFP lentiviral reporter vector for detection and in vivo isolation of label-retaining cells. Falkowska-Hansen B, Kollar J, Gruner BM, Schanz M, Boukamp P, Siveke J, Rethwilm A, Kirschner M. Exp Cell Res. 2010 Jul 1;316(11):1885-95. doi: 10.1016/j.yexcr.2010.02.015. Epub 2010 Feb 18. PubMed |
| Tumor necrosis factor receptor superfamily member 19 (TNFRSF19) regulates differentiation fate of human mesenchymal (stromal) stem cells through canonical Wnt signaling and C/EBP. Qiu W, Hu Y, Andersen TE, Jafari A, Li N, Chen W, Kassem M. J Biol Chem. 2010 May 7;285(19):14438-49. doi: 10.1074/jbc.M109.052001. Epub 2010 Mar 11. PubMed |
| Lentiviral vector-mediated transgenesis in human embryonic stem cells. Du ZW, Zhang SC. Methods Mol Biol. 2010;614:127-34. doi: 10.1007/978-1-60761-533-0_8. PubMed |
| Aire regulates the expression of differentiation-associated genes and self-renewal of embryonic stem cells. Gu B, Zhang J, Chen Q, Tao B, Wang W, Zhou Y, Chen L, Liu Y, Zhang M. Biochem Biophys Res Commun. 2010 Apr 2. 394(2):418-23. PubMed |
| Pbx1 represses osteoblastogenesis by blocking Hoxa10-mediated recruitment of chromatin remodeling factors. Gordon JA, Hassan MQ, Saini S, Montecino M, van Wijnen AJ, Stein GS, Stein JL, Lian JB. Mol Cell Biol. 2010 Jul;30(14):3531-41. doi: 10.1128/MCB.00889-09. Epub 2010 May 3. PubMed |
| Differential splicing of the apoptosis-associated speck like protein containing a caspase recruitment domain (ASC) regulates inflammasomes. Bryan NB, Dorfleutner A, Kramer SJ, Yun C, Rojanasakul Y, Stehlik C. J Inflamm (Lond). 2010 May 18;7:23. doi: 10.1186/1476-9255-7-23. PubMed |
| The cell-specific induction of CXC chemokine ligand 9 mediated by IFN-gamma in microglia of the central nervous system is determined by the myeloid transcription factor PU.1. Ellis SL, Gysbers V, Manders PM, Li W, Hofer MJ, Muller M, Campbell IL. J Immunol. 2010 Aug 1;185(3):1864-77. doi: 10.4049/jimmunol.1000900. Epub 2010 Jun 28. PubMed |
| A novel, retromer-independent role for sorting nexins 1 and 2 in RhoG-dependent membrane remodeling. Prosser DC, Tran D, Schooley A, Wendland B, Ngsee JK. Traffic. 2010 Oct;11(10):1347-62. doi: 10.1111/j.1600-0854.2010.01100.x. PubMed |
| EGFR/Met association regulates EGFR TKI resistance in breast cancer. Mueller KL, Yang ZQ, Haddad R, Ethier SP, Boerner JL. J Mol Signal. 2010 Jul 12;5:8. doi: 10.1186/1750-2187-5-8. PubMed |
| Two functionally distinct isoforms of TL1A (TNFSF15) generated by differential ectodomain shedding. Muck C, Herndler-Brandstetter D, Micutkova L, Grubeck-Loebenstein B, Jansen-Durr P. J Gerontol A Biol Sci Med Sci. 2010 Nov;65(11):1165-80. doi: 10.1093/gerona/glq129. Epub 2010 Jul 30. PubMed |
| A neuroregenerative human ensheathing glia cell line with conditional rapid growth. Garcia-Escudero V, Gargini R, Gallego-Hernandez MT, Garcia-Gomez A, Martin-Bermejo MJ, Simon D, Delicado A, Moreno-Flores MT, Avila J, Lim F. Cell Transplant. 2011;20(2):153-66. doi: 10.3727/096368910X522108. Epub 2010 Aug 18. PubMed |
| Expression of miR-33 from an SREBP2 intron inhibits cholesterol export and fatty acid oxidation. Gerin I, Clerbaux LA, Haumont O, Lanthier N, Das AK, Burant CF, Leclercq IA, MacDougald OA, Bommer GT. J Biol Chem. 2010 Oct 29;285(44):33652-61. doi: 10.1074/jbc.M110.152090. Epub 2010 Aug 22. PubMed |
| Stable overexpression of miRNAs in bone marrow-derived murine mast cells using lentiviral expression vectors. Mayoral RJ, Monticelli S. Methods Mol Biol. 2010;667:205-14. doi: 10.1007/978-1-60761-811-9_14. PubMed |
| Incremental genetic perturbations to MCM2-7 expression and subcellular distribution reveal exquisite sensitivity of mice to DNA replication stress. Chuang CH, Wallace MD, Abratte C, Southard T, Schimenti JC. PLoS Genet. 2010 Sep 9;6(9):e1001110. doi: 10.1371/journal.pgen.1001110. PubMed |
| Syntaxin 3 is necessary for cAMP- and cGMP-regulated exocytosis of CFTR: implications for enterotoxigenic diarrhea. Collaco A, Marathe J, Kohnke H, Kravstov D, Ameen N. Am J Physiol Cell Physiol. 2010 Dec;299(6):C1450-60. doi: 10.1152/ajpcell.00029.2010. Epub 2010 Sep 15. PubMed |
| Role for PKC delta in Fenretinide-Mediated Apoptosis in Lymphoid Leukemia Cells. Ruvolo VR, Karanjeet KB, Schuster TF, Brown R, Deng Y, Hinchcliffe E, Ruvolo PP. J Signal Transduct. 2010 Jan 1;2010:584657. PubMed |
| ATR and ATRIP are recruited to herpes simplex virus type 1 replication compartments even though ATR signaling is disabled. Mohni KN, Livingston CM, Cortez D, Weller SK. J Virol. 2010 Dec;84(23):12152-64. doi: 10.1128/JVI.01643-10. Epub 2010 Sep 22. PubMed |
| Induced pluripotent stem cell models of the genomic imprinting disorders Angelman and Prader-Willi syndromes. Chamberlain SJ, Chen PF, Ng KY, Bourgois-Rocha F, Lemtiri-Chlieh F, Levine ES, Lalande M. Proc Natl Acad Sci U S A. 2010 Oct 12;107(41):17668-73. doi: 10.1073/pnas.1004487107. Epub 2010 Sep 27. PubMed |
| Dual selection mechanisms drive efficient single-gene reverse genetics for rotavirus. Trask SD, Taraporewala ZF, Boehme KW, Dermody TS, Patton JT. Proc Natl Acad Sci U S A. 2010 Oct 26;107(43):18652-7. doi: 10.1073/pnas.1011948107. Epub 2010 Oct 11. PubMed |
| The SR-BI partner PDZK1 facilitates hepatitis C virus entry. Eyre NS, Drummer HE, Beard MR. PLoS Pathog. 2010 Oct 7;6(10):e1001130. doi: 10.1371/journal.ppat.1001130. PubMed |
| Silencing of CDK5 reduces neurofibrillary tangles in transgenic alzheimer's mice. Piedrahita D, Hernandez I, Lopez-Tobon A, Fedorov D, Obara B, Manjunath BS, Boudreau RL, Davidson B, Laferla F, Gallego-Gomez JC, Kosik KS, Cardona-Gomez GP. J Neurosci. 2010 Oct 20;30(42):13966-76. doi: 10.1523/JNEUROSCI.3637-10.2010. PubMed |
| Combining theoretical analysis and experimental data generation reveals IRF9 as a crucial factor for accelerating interferon alpha-induced early antiviral signalling. Maiwald T, Schneider A, Busch H, Sahle S, Gretz N, Weiss TS, Kummer U, Klingmuller U. FEBS J. 2010 Nov;277(22):4741-54. doi: 10.1111/j.1742-4658.2010.07880.x. Epub 2010 Oct 21. PubMed |
Large intergenic non-coding RNA-RoR modulates reprogramming of human induced pluripotent stem cells.
Loewer S, Cabili MN, Guttman M, Loh YH, Thomas K, Park IH, Garber M, Curran M, Onder T, Agarwal S, Manos PD, Datta S, Lander ES, Schlaeger TM, Daley GQ, Rinn JL.
Nat Genet. 2010 Dec;42(12):1113-7. Epub 2010 Nov 7.
PubMed
Associated Plasmids |
| The TRAF-interacting protein (TRIP) is a regulator of keratinocyte proliferation. Almeida S, Ryser S, Obarzanek-Fojt M, Hohl D, Huber M. J Invest Dermatol. 2011 Feb;131(2):349-57. doi: 10.1038/jid.2010.329. Epub 2010 Nov 11. PubMed |
| Prolylcarboxypeptidase regulates proliferation, autophagy, and resistance to 4-hydroxytamoxifen-induced cytotoxicity in estrogen receptor-positive breast cancer cells. Duan L, Motchoulski N, Danzer B, Davidovich I, Shariat-Madar Z, Levenson VV. J Biol Chem. 2011 Jan 28;286(4):2864-76. doi: 10.1074/jbc.M110.143271. Epub 2010 Nov 17. PubMed |
| T cell receptor (TCR)-induced tyrosine phosphorylation dynamics identifies THEMIS as a new TCR signalosome component. Brockmeyer C, Paster W, Pepper D, Tan CP, Trudgian DC, McGowan S, Fu G, Gascoigne NR, Acuto O, Salek M. J Biol Chem. 2011 Mar 4;286(9):7535-47. doi: 10.1074/jbc.M110.201236. Epub 2010 Dec 28. PubMed |
| Akt1 deletion prevents lung tumorigenesis by mutant K-ras. Hollander MC, Maier CR, Hobbs EA, Ashmore AR, Linnoila RI, Dennis PA. Oncogene. 2011 Apr 14;30(15):1812-21. doi: 10.1038/onc.2010.556. Epub 2011 Jan 17. PubMed |
| Human umbilical cord-derived Schwann-like cell transplantation combined with neurotrophin-3 administration in dyskinesia of rats with spinal cord injury. Yan-Wu G, Yi-Quan K, Ming L, Ying-Qian C, Xiao-Dan J, Shi-Zhong Z, Wang-Ming Z, Chuan-Zhi D. Neurochem Res. 2011 May;36(5):783-92. doi: 10.1007/s11064-011-0402-9. Epub 2011 Jan 18. PubMed |
| Senescence-associated heterochromatin foci are dispensable for cellular senescence, occur in a cell type- and insult-dependent manner and follow expression of p16(ink4a). Kosar M, Bartkova J, Hubackova S, Hodny Z, Lukas J, Bartek J. Cell Cycle. 2011 Feb 1;10(3):457-68. Epub 2011 Feb 1. PubMed |
| Yes-associated protein (YAP) transcriptional coactivator functions in balancing growth and differentiation in skin. Zhang H, Pasolli HA, Fuchs E. Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2270-5. doi: 10.1073/pnas.1019603108. Epub 2011 Jan 24. PubMed |
| JNK signaling promotes intestinal tumorigenesis through activation of mTOR complex 1 in Apc(Delta716) mice. Fujishita T, Aoki M, Taketo MM. Gastroenterology. 2011 May;140(5):1556-63.e6. doi: 10.1053/j.gastro.2011.02.007. Epub 2011 Feb 12. PubMed |
| High-throughput screening of microscale pitted substrate topographies for enhanced nonviral transfection efficiency in primary human fibroblasts. Adler AF, Speidel AT, Christoforou N, Kolind K, Foss M, Leong KW. Biomaterials. 2011 May;32(14):3611-9. doi: 10.1016/j.biomaterials.2011.01.040. Epub 2011 Feb 21. PubMed |
| Recapitulation of premature ageing with iPSCs from Hutchinson-Gilford progeria syndrome. Liu GH, Barkho BZ, Ruiz S, Diep D, Qu J, Yang SL, Panopoulos AD, Suzuki K, Kurian L, Walsh C, Thompson J, Boue S, Fung HL, Sancho-Martinez I, Zhang K, Yates J 3rd, Izpisua Belmonte JC. Nature. 2011 Apr 14;472(7342):221-5. doi: 10.1038/nature09879. Epub 2011 Feb 23. PubMed |
| The neuronal differentiation factor NeuroD1 downregulates the neuronal repellent factor Slit2 expression and promotes cell motility and tumor formation of neuroblastoma. Huang P, Kishida S, Cao D, Murakami-Tonami Y, Mu P, Nakaguro M, Koide N, Takeuchi I, Onishi A, Kadomatsu K. Cancer Res. 2011 Apr 15;71(8):2938-48. doi: 10.1158/0008-5472.CAN-10-3524. Epub 2011 Feb 24. PubMed |
| SirT3 suppresses hypoxia inducible factor 1alpha and tumor growth by inhibiting mitochondrial ROS production. Bell EL, Emerling BM, Ricoult SJ, Guarente L. Oncogene. 2011 Jun 30;30(26):2986-96. doi: 10.1038/onc.2011.37. Epub 2011 Feb 28. PubMed |
| Somatic coding mutations in human induced pluripotent stem cells. Gore A, Li Z, Fung HL, Young JE, Agarwal S, Antosiewicz-Bourget J, Canto I, Giorgetti A, Israel MA, Kiskinis E, Lee JH, Loh YH, Manos PD, Montserrat N, Panopoulos AD, Ruiz S, Wilbert ML, Yu J, Kirkness EF, Izpisua Belmonte JC, Rossi DJ, Thomson JA, Eggan K, Daley GQ, Goldstein LS, Zhang K. Nature. 2011 Mar 3;471(7336):63-7. doi: 10.1038/nature09805. PubMed |
| S1P lyase regulates DNA damage responses through a novel sphingolipid feedback mechanism. Kumar A, Oskouian B, Fyrst H, Zhang M, Paris F, Saba JD. Cell Death Dis. 2011 Feb 10;2:e119. doi: 10.1038/cddis.2011.3. PubMed |
| Lentiviral vector mediated modification of mesenchymal stem cells & enhanced survival in an in vitro model of ischaemia. McGinley L, McMahon J, Strappe P, Barry F, Murphy M, O'Toole D, O'Brien T. Stem Cell Res Ther. 2011 Mar 7;2(2):12. doi: 10.1186/scrt53. PubMed |
| Mutation and loss of expression of ARID1A in uterine low-grade endometrioid carcinoma. Guan B, Mao TL, Panuganti PK, Kuhn E, Kurman RJ, Maeda D, Chen E, Jeng YM, Wang TL, Shih IeM. Am J Surg Pathol. 2011 May;35(5):625-32. doi: 10.1097/PAS.0b013e318212782a. PubMed |
| Anthrax lethal factor activates K(+) channels to induce IL-1beta secretion in macrophages. Thomas J, Epshtein Y, Chopra A, Ordog B, Ghassemi M, Christman JW, Nattel S, Cook JL, Levitan I. J Immunol. 2011 May 1;186(9):5236-43. doi: 10.4049/jimmunol.1001078. Epub 2011 Mar 18. PubMed |
| Histone demethylase JMJD2B functions as a co-factor of estrogen receptor in breast cancer proliferation and mammary gland development. Kawazu M, Saso K, Tong KI, McQuire T, Goto K, Son DO, Wakeham A, Miyagishi M, Mak TW, Okada H. PLoS One. 2011 Mar 18;6(3):e17830. doi: 10.1371/journal.pone.0017830. PubMed |
| HIV infection enhances TRAIL-induced cell death in macrophage by down-regulating decoy receptor expression and generation of reactive oxygen species. Zhu DM, Shi J, Liu S, Liu Y, Zheng D. PLoS One. 2011 Apr 5;6(4):e18291. doi: 10.1371/journal.pone.0018291. PubMed |
| The NLR adaptor ASC/PYCARD regulates DUSP10, mitogen-activated protein kinase (MAPK), and chemokine induction independent of the inflammasome. Taxman DJ, Holley-Guthrie EA, Huang MT, Moore CB, Bergstralh DT, Allen IC, Lei Y, Gris D, Ting JP. J Biol Chem. 2011 Jun 3;286(22):19605-16. doi: 10.1074/jbc.M111.221077. Epub 2011 Apr 12. PubMed |
| Efficient preparation and labeling of human induced pluripotent stem cells by nanotechnology. Ruan J, Shen J, Wang Z, Ji J, Song H, Wang K, Liu B, Li J, Cui D. Int J Nanomedicine. 2011;6:425-35. doi: 10.2147/IJN.S16498. Epub 2011 Feb 21. PubMed |
| mTORC1 inhibition increases neurotensin secretion and gene expression through activation of the MEK/ERK/c-Jun pathway in the human endocrine cell line BON. Li J, Liu J, Song J, Wang X, Weiss HL, Townsend CM Jr, Gao T, Evers BM. Am J Physiol Cell Physiol. 2011 Jul;301(1):C213-26. doi: 10.1152/ajpcell.00067.2011. Epub 2011 Apr 20. PubMed |
| Human cytomegalovirus IE1 protein elicits a type II interferon-like host cell response that depends on activated STAT1 but not interferon-gamma. Knoblach T, Grandel B, Seiler J, Nevels M, Paulus C. PLoS Pathog. 2011 Apr;7(4):e1002016. doi: 10.1371/journal.ppat.1002016. Epub 2011 Apr 14. PubMed |
| Modeling initiation of Ewing sarcoma in human neural crest cells. von Levetzow C, Jiang X, Gwye Y, von Levetzow G, Hung L, Cooper A, Hsu JH, Lawlor ER. PLoS One. 2011 Apr 29;6(4):e19305. doi: 10.1371/journal.pone.0019305. PubMed |
| The function of hypoxia-inducible factor (HIF) is independent of the endoplasmic reticulum protein OS-9. Brockmeier U, Platzek C, Schneider K, Patak P, Bernardini A, Fandrey J, Metzen E. PLoS One. 2011 Apr 29;6(4):e19151. doi: 10.1371/journal.pone.0019151. PubMed |
| Epigenetic regulation of early osteogenesis and mineralized tissue formation by a HOXA10-PBX1-associated complex. Gordon JA, Hassan MQ, Koss M, Montecino M, Selleri L, van Wijnen AJ, Stein JL, Stein GS, Lian JB. Cells Tissues Organs. 2011;194(2-4):146-50. doi: 10.1159/000324790. Epub 2011 May 19. PubMed |
| Deptor knockdown enhances mTOR Activity and protein synthesis in myocytes and ameliorates disuse muscle atrophy. Kazi AA, Hong-Brown L, Lang SM, Lang CH. Mol Med. 2011 Sep-Oct;17(9-10):925-36. doi: 10.2119/molmed.2011.00070. Epub 2011 May 19. PubMed |
| Transforming growth factor beta controls CCN3 expression in nucleus pulposus cells of the intervertebral disc. Tran CM, Smith HE, Symes A, Rittie L, Perbal B, Shapiro IM, Risbud MV. Arthritis Rheum. 2011 Oct;63(10):3022-31. doi: 10.1002/art.30468. PubMed |
| Faster generation of hiPSCs by coupling high-titer lentivirus and column-based positive selection. Dick E, Matsa E, Young LE, Darling D, Denning C. Nat Protoc. 2011 Jun;6(6):701-14. doi: 10.1038/nprot.2011.320. Epub 2011 May 5. PubMed |
| Lipid raft localization of EGFR alters the response of cancer cells to the EGFR tyrosine kinase inhibitor gefitinib. Irwin ME, Mueller KL, Bohin N, Ge Y, Boerner JL. J Cell Physiol. 2011 Sep;226(9):2316-28. doi: 10.1002/jcp.22570. PubMed |
| Stable knockdown of MYCN by lentivirus-based RNAi inhibits human neuroblastoma cells growth in vitro and in vivo. Jiang R, Xue S, Jin Z. Biochem Biophys Res Commun. 2011 Jul 1;410(2):364-70. doi: 10.1016/j.bbrc.2011.06.020. Epub 2011 Jun 12. PubMed |
| L-3-Phosphoserine phosphatase (PSPH) regulates cutaneous squamous cell carcinoma proliferation independent of L-serine biosynthesis. Bachelor MA, Lu Y, Owens DM. J Dermatol Sci. 2011 Sep;63(3):164-72. doi: 10.1016/j.jdermsci.2011.06.001. Epub 2011 Jun 22. PubMed |
| Hypoxia leads to Na,K-ATPase downregulation via Ca(2+) release-activated Ca(2+) channels and AMPK activation. Gusarova GA, Trejo HE, Dada LA, Briva A, Welch LC, Hamanaka RB, Mutlu GM, Chandel NS, Prakriya M, Sznajder JI. Mol Cell Biol. 2011 Sep;31(17):3546-56. doi: 10.1128/MCB.05114-11. Epub 2011 Jul 5. PubMed |
| Lentiviral-mediated knockdown during ex vivo erythropoiesis of human hematopoietic stem cells. Palii CG, Pasha R, Brand M. J Vis Exp. 2011 Jul 16;(53). pii: 2813. doi: 10.3791/2813. PubMed |
| Endothelial cells create a stem cell niche in glioblastoma by providing NOTCH ligands that nurture self-renewal of cancer stem-like cells. Zhu TS, Costello MA, Talsma CE, Flack CG, Crowley JG, Hamm LL, He X, Hervey-Jumper SL, Heth JA, Muraszko KM, DiMeco F, Vescovi AL, Fan X. Cancer Res. 2011 Sep 15;71(18):6061-72. doi: 10.1158/0008-5472.CAN-10-4269. Epub 2011 Jul 25. PubMed |
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| Loss of transcription factor KLF5 in the context of p53 ablation drives invasive progression of human squamous cell cancer. Yang Y, Nakagawa H, Tetreault MP, Billig J, Victor N, Goyal A, Sepulveda AR, Katz JP. Cancer Res. 2011 Oct 15;71(20):6475-84. doi: 10.1158/0008-5472.CAN-11-1702. Epub 2011 Aug 25. PubMed |
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| Disruption of Wnt planar cell polarity signaling by aberrant accumulation of the MetAP-2 substrate Rab37. Sundberg TB, Darricarrere N, Cirone P, Li X, McDonald L, Mei X, Westlake CJ, Slusarski DC, Beynon RJ, Crews CM. Chem Biol. 2011 Oct 28;18(10):1300-11. doi: 10.1016/j.chembiol.2011.07.020. PubMed |
| FGF signalling inhibits neural induction in human embryonic stem cells. Greber B, Coulon P, Zhang M, Moritz S, Frank S, Muller-Molina AJ, Arauzo-Bravo MJ, Han DW, Pape HC, Scholer HR. EMBO J. 2011 Nov 15;30(24):4874-84. doi: 10.1038/emboj.2011.407. PubMed |
| Excitation-induced ataxin-3 aggregation in neurons from patients with Machado-Joseph disease. Koch P, Breuer P, Peitz M, Jungverdorben J, Kesavan J, Poppe D, Doerr J, Ladewig J, Mertens J, Tuting T, Hoffmann P, Klockgether T, Evert BO, Wullner U, Brustle O. Nature. 2011 Nov 23;480(7378):543-6. doi: 10.1038/nature10671. PubMed |
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| GABAergic circuits mediate the reinforcement-related signals of striatal cholinergic interneurons. English DF, Ibanez-Sandoval O, Stark E, Tecuapetla F, Buzsaki G, Deisseroth K, Tepper JM, Koos T. Nat Neurosci. 2011 Dec 11;15(1):123-30. doi: 10.1038/nn.2984. PubMed |
| Development of immortalized hepatocyte-like cells from hMSCs. Wongkajornsilp A, Sa-Ngiamsuntorn K, Hongeng S. Methods Mol Biol. 2012;826:73-87. doi: 10.1007/978-1-61779-468-1_7. PubMed |
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Modulation of Wnt/beta-catenin signaling in human embryonic stem cells using a 3-D microwell array.
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| Pygo2 regulates histone gene expression and H3 K56 acetylation in human mammary epithelial cells. Gu B, Watanabe K, Dai X. Cell Cycle. 2012 Jan 1;11(1):79-87. doi: 10.4161/cc.11.1.18402. Epub 2012 Jan 1. PubMed |
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| Retinoblastoma tumor-suppressor protein phosphorylation and inactivation depend on direct interaction with Pin1. Rizzolio F, Lucchetti C, Caligiuri I, Marchesi I, Caputo M, Klein-Szanto AJ, Bagella L, Castronovo M, Giordano A. Cell Death Differ. 2012 Jul;19(7):1152-61. doi: 10.1038/cdd.2011.202. Epub 2012 Feb 10. PubMed |
| Impairment of lysosomal integrity by B10, a glycosylated derivative of betulinic acid, leads to lysosomal cell death and converts autophagy into a detrimental process. Gonzalez P, Mader I, Tchoghandjian A, Enzenmuller S, Cristofanon S, Basit F, Debatin KM, Fulda S. Cell Death Differ. 2012 Aug;19(8):1337-46. doi: 10.1038/cdd.2012.10. Epub 2012 Feb 17. PubMed |
| Angiogenic properties of myofibroblasts isolated from normal human skin wounds. Mayrand D, Laforce-Lavoie A, Larochelle S, Langlois A, Genest H, Roy M, Moulin VJ. Angiogenesis. 2012 Jun;15(2):199-212. doi: 10.1007/s10456-012-9253-5. Epub 2012 Feb 18. PubMed |
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| Expression of prolyl hydroxylases (PHDs) is selectively controlled by HIF-1 and HIF-2 proteins in nucleus pulposus cells of the intervertebral disc: distinct roles of PHD2 and PHD3 proteins in controlling HIF-1alpha activity in hypoxia. Fujita N, Markova D, Anderson DG, Chiba K, Toyama Y, Shapiro IM, Risbud MV. J Biol Chem. 2012 May 11;287(20):16975-86. doi: 10.1074/jbc.M111.334466. Epub 2012 Mar 26. PubMed |
| Pathogen-induced human TH17 cells produce IFN-gamma or IL-10 and are regulated by IL-1beta. Zielinski CE, Mele F, Aschenbrenner D, Jarrossay D, Ronchi F, Gattorno M, Monticelli S, Lanzavecchia A, Sallusto F. Nature. 2012 Apr 26;484(7395):514-8. doi: 10.1038/nature10957. PubMed |
| IL1beta induces mesenchymal stem cells migration and leucocyte chemotaxis through NF-kappaB. Carrero R, Cerrada I, Lledo E, Dopazo J, Garcia-Garcia F, Rubio MP, Trigueros C, Dorronsoro A, Ruiz-Sauri A, Montero JA, Sepulveda P. Stem Cell Rev. 2012 Sep;8(3):905-16. doi: 10.1007/s12015-012-9364-9. PubMed |
| Heightened expression of MICA enhances the cytotoxicity of NK cells or CD8+T cells to human corneal epithelium in vitro. Hong J, Qiu T, Qian T, Li G, Yu X, Chen J, Le Q, Sun X, Xu J. BMC Ophthalmol. 2012 Apr 4;12:6. doi: 10.1186/1471-2415-12-6. PubMed |
| RGB marking with lentiviral vectors for multicolor clonal cell tracking. Weber K, Thomaschewski M, Benten D, Fehse B. Nat Protoc. 2012 Apr 5;7(5):839-49. doi: 10.1038/nprot.2012.026. PubMed |
| Zfp296 is a novel, pluripotent-specific reprogramming factor. Fischedick G, Klein DC, Wu G, Esch D, Hoing S, Han DW, Reinhardt P, Hergarten K, Tapia N, Scholer HR, Sterneckert JL. PLoS One. 2012;7(4):e34645. doi: 10.1371/journal.pone.0034645. Epub 2012 Apr 2. PubMed |
| Human-induced pluripotent stem cells form functional neurons and improve recovery after grafting in stroke-damaged brain. Oki K, Tatarishvili J, Wood J, Koch P, Wattananit S, Mine Y, Monni E, Tornero D, Ahlenius H, Ladewig J, Brustle O, Lindvall O, Kokaia Z. Stem Cells. 2012 Jun;30(6):1120-33. doi: 10.1002/stem.1104. PubMed |
| Carbonic anhydrase III regulates peroxisome proliferator-activated receptor-gamma2. Mitterberger MC, Kim G, Rostek U, Levine RL, Zwerschke W. Exp Cell Res. 2012 May 1;318(8):877-86. doi: 10.1016/j.yexcr.2012.02.011. Epub 2012 Feb 28. PubMed |
| Myosin Ia is required for CFTR brush border membrane trafficking and ion transport in the mouse small intestine. Kravtsov DV, Caputo C, Collaco A, Hoekstra N, Egan ME, Mooseker MS, Ameen NA. Traffic. 2012 Aug;13(8):1072-82. doi: 10.1111/j.1600-0854.2012.01368.x. Epub 2012 May 8. PubMed |
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| Aire promotes the self-renewal of embryonic stem cells through Lin28. Bin G, Jiarong Z, Shihao W, Xiuli S, Cheng X, Liangbiao C, Ming Z. Stem Cells Dev. 2012 Oct 10;21(15):2878-90. doi: 10.1089/scd.2012.0097. Epub 2012 Jun 11. PubMed |
Identification of the human PMR1 mRNA endonuclease as an alternatively processed product of the gene for peroxidasin-like protein.
Gu SQ, Bakthavachalu B, Han J, Patil DP, Otsuka Y, Guda C, Schoenberg DR.
RNA. 2012 Jun;18(6):1186-96. doi: 10.1261/rna.031369.111. Epub 2012 Apr 27.
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| LASS2 enhances chemosensitivity of breast cancer by counteracting acidic tumor microenvironment through inhibiting activity of V-ATPase proton pump. Fan S, Niu Y, Tan N, Wu Z, Wang Y, You H, Ke R, Song J, Shen Q, Wang W, Yao G, Shu H, Lin H, Yao M, Zhang Z, Gu J, Qin W. Oncogene. 2013 Mar 28;32(13):1682-90. doi: 10.1038/onc.2012.183. Epub 2012 May 14. PubMed |
| Identification of novel human damage response proteins targeted through yeast orthology. Svensson JP, Fry RC, Wang E, Somoza LA, Samson LD. PLoS One. 2012;7(5):e37368. doi: 10.1371/journal.pone.0037368. Epub 2012 May 16. PubMed |
| DLK1(PREF1) is a negative regulator of adipogenesis in CD105(+)/CD90(+)/CD34(+)/CD31(-)/FABP4(-) adipose-derived stromal cells from subcutaneous abdominal fat pats of adult women. Mitterberger MC, Lechner S, Mattesich M, Kaiser A, Probst D, Wenger N, Pierer G, Zwerschke W. Stem Cell Res. 2012 Jul;9(1):35-48. doi: 10.1016/j.scr.2012.04.001. Epub 2012 Apr 17. PubMed |
| Smad3 controls beta-1,3-glucuronosyltransferase 1 expression in rat nucleus pulposus cells: implications of dysregulated expression in disc disease. Wu Q, Wang J, Skubutyte R, Kepler CK, Huang Z, Anderson DG, Shapiro IM, Risbud MV. Arthritis Rheum. 2012 Oct;64(10):3324-33. doi: 10.1002/art.34570. PubMed |
| Morphology of axonal projections from the high vocal center to vocal motor cortex in songbirds. Yip ZC, Miller-Sims VC, Bottjer SW. J Comp Neurol. 2012 Aug 15;520(12):2742-56. doi: 10.1002/cne.23084. PubMed |
| gamma-Secretase inhibition promotes cell death, Noxa upregulation, and sensitization to BH3 mimetic ABT-737 in human breast cancer cells. Seveno C, Loussouarn D, Brechet S, Campone M, Juin P, Barille-Nion S. Breast Cancer Res. 2012 Jun 15;14(3):R96. PubMed |
| A versatile lentiviral expression system to identify mammalian protein-protein interactions. Mak AB, Moffat J. Methods. 2012 Aug;57(4):409-16. doi: 10.1016/j.ymeth.2012.06.005. Epub 2012 Jun 17. PubMed |
| Inverted Alu dsRNA structures do not affect localization but can alter translation efficiency of human mRNAs independent of RNA editing. Capshew CR, Dusenbury KL, Hundley HA. Nucleic Acids Res. 2012 Sep 1;40(17):8637-45. Epub 2012 Jun 25. PubMed |
| Iterative capped assembly: rapid and scalable synthesis of repeat-module DNA such as TAL effectors from individual monomers. Briggs AW, Rios X, Chari R, Yang L, Zhang F, Mali P, Church GM. Nucleic Acids Res. 2012 Aug;40(15):e117. doi: 10.1093/nar/gks624. Epub 2012 Jun 26. PubMed |
| Fibroblast-secreted hepatocyte growth factor mediates epidermal growth factor receptor tyrosine kinase inhibitor resistance in triple-negative breast cancers through paracrine activation of Met. Mueller KL, Madden JM, Zoratti GL, Kuperwasser C, List K, Boerner JL. Breast Cancer Res. 2012 Jul 12;14(4):R104. doi: 10.1186/bcr3224. PubMed |
| Role of mismatch repair enzymes in GAA.TTC triplet-repeat expansion in Friedreich ataxia induced pluripotent stem cells. Du J, Campau E, Soragni E, Ku S, Puckett JW, Dervan PB, Gottesfeld JM. J Biol Chem. 2012 Aug 24;287(35):29861-72. doi: 10.1074/jbc.M112.391961. Epub 2012 Jul 13. PubMed |
| Expression of the PTTG1 oncogene is associated with aggressive clear cell renal cell carcinoma. Wondergem B, Zhang Z, Huang D, Ong CK, Koeman J, Hof DV, Petillo D, Ooi A, Anema J, Lane B, Kahnoski RJ, Furge KA, Teh BT. Cancer Res. 2012 Sep 1;72(17):4361-71. doi: 10.1158/0008-5472.CAN-11-2330. Epub 2012 Jul 17. PubMed |
| Cytokine secretion by CD4+ T cells at the immunological synapse requires Cdc42-dependent local actin remodeling but not microtubule organizing center polarity. Chemin K, Bohineust A, Dogniaux S, Tourret M, Guegan S, Miro F, Hivroz C. J Immunol. 2012 Sep 1;189(5):2159-68. doi: 10.4049/jimmunol.1200156. Epub 2012 Jul 20. PubMed |
| ASC-dependent RIP2 kinase regulates reduced PGE2 production in chronic periodontitis. Taxman DJ, Lei Y, Zhang S, Holley-Guthrie E, Offenbacher S, Ting JP. J Dent Res. 2012 Sep;91(9):877-82. doi: 10.1177/0022034512454541. Epub 2012 Jul 24. PubMed |
| Synthesis and evaluation of hybrid drugs for a potential HIV/AIDS-malaria combination therapy. Aminake MN, Mahajan A, Kumar V, Hans R, Wiesner L, Taylor D, de Kock C, Grobler A, Smith PJ, Kirschner M, Rethwilm A, Pradel G, Chibale K. Bioorg Med Chem. 2012 Sep 1;20(17):5277-89. doi: 10.1016/j.bmc.2012.06.038. Epub 2012 Jun 29. PubMed |
| Genetic background affects induced pluripotent stem cell generation. Schnabel LV, Abratte CM, Schimenti JC, Southard TL, Fortier LA. Stem Cell Res Ther. 2012 Aug 3;3(4):30. doi: 10.1186/scrt121. PubMed |
| Inhibiting adipose tissue lipogenesis reprograms thermogenesis and PPARgamma activation to decrease diet-induced obesity. Lodhi IJ, Yin L, Jensen-Urstad AP, Funai K, Coleman T, Baird JH, El Ramahi MK, Razani B, Song H, Fu-Hsu F, Turk J, Semenkovich CF. Cell Metab. 2012 Aug 8;16(2):189-201. PubMed |
| Autophagy is a protective response to ethanol neurotoxicity. Chen G, Ke Z, Xu M, Liao M, Wang X, Qi Y, Zhang T, Frank JA, Bower KA, Shi X, Luo J. Autophagy. 2012 Nov;8(11):1577-89. doi: 10.4161/auto.21376. Epub 2012 Aug 9. PubMed |
| Androgen receptor serine 81 mediates Pin1 interaction and activity. La Montagna R, Caligiuri I, Maranta P, Lucchetti C, Esposito L, Paggi MG, Toffoli G, Rizzolio F, Giordano A. Cell Cycle. 2012 Sep 15;11(18):3415-20. doi: 10.4161/cc.21730. Epub 2012 Aug 16. PubMed |
| Elevating SOX2 levels deleteriously affects the growth of medulloblastoma and glioblastoma cells. Cox JL, Wilder PJ, Desler M, Rizzino A. PLoS One. 2012;7(8):e44087. doi: 10.1371/journal.pone.0044087. Epub 2012 Aug 28. PubMed |
| Prolyl hydroxylase 3 (PHD3) modulates catabolic effects of tumor necrosis factor-alpha (TNF-alpha) on cells of the nucleus pulposus through co-activation of nuclear factor kappaB (NF-kappaB)/p65 signaling. Fujita N, Gogate SS, Chiba K, Toyama Y, Shapiro IM, Risbud MV. J Biol Chem. 2012 Nov 16;287(47):39942-53. doi: 10.1074/jbc.M112.375964. Epub 2012 Sep 4. PubMed |
| Autophagy plays a protective role in endoplasmic reticulum stress-mediated pancreatic beta cell death. Bartolome A, Guillen C, Benito M. Autophagy. 2012 Dec;8(12):1757-68. doi: 10.4161/auto.21994. Epub 2012 Sep 5. PubMed |
| Mouse models for tumor metastasis. Yang S, Zhang JJ, Huang XY. Methods Mol Biol. 2012;928:221-8. doi: 10.1007/978-1-62703-008-3_17. PubMed |
| AIF-mediated caspase-independent necroptosis requires ATM and DNA-PK-induced histone H2AX Ser139 phosphorylation. Baritaud M, Cabon L, Delavallee L, Galan-Malo P, Gilles ME, Brunelle-Navas MN, Susin SA. Cell Death Dis. 2012 Sep 13;3:e390. doi: 10.1038/cddis.2012.120. PubMed |
| Mechanism of capsaicin receptor TRPV1-mediated toxicity in pain-sensing neurons focusing on the effects of Na(+)/Ca(2+) fluxes and the Ca(2+)-binding protein calretinin. Pecze L, Blum W, Schwaller B. Biochim Biophys Acta. 2013 Jul;1833(7):1680-91. doi: 10.1016/j.bbamcr.2012.08.018. Epub 2012 Sep 5. PubMed |
| The ablation of EZH2 uncovers its crucial role in rhabdomyosarcoma formation. Marchesi I, Fiorentino FP, Rizzolio F, Giordano A, Bagella L. Cell Cycle. 2012 Oct 15;11(20):3828-36. doi: 10.4161/cc.22025. Epub 2012 Sep 14. PubMed |
p53 mutation alters the effect of the esophageal tumor suppressor KLF5 on keratinocyte proliferation.
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| Calcium-permeable alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors trigger neuronal nitric-oxide synthase activation to promote nerve cell death in an Src kinase-dependent fashion. Socodato R, Santiago FN, Portugal CC, Domingues AF, Santiago AR, Relvas JB, Ambrosio AF, Paes-de-Carvalho R. J Biol Chem. 2012 Nov 9;287(46):38680-94. doi: 10.1074/jbc.M112.353961. Epub 2012 Sep 19. PubMed |
| Codon-usage-based inhibition of HIV protein synthesis by human schlafen 11. Li M, Kao E, Gao X, Sandig H, Limmer K, Pavon-Eternod M, Jones TE, Landry S, Pan T, Weitzman MD, David M. Nature. 2012 Nov 1;491(7422):125-8. doi: 10.1038/nature11433. Epub 2012 Sep 23. PubMed |
| The cellular ataxia telangiectasia-mutated kinase promotes epstein-barr virus lytic reactivation in response to multiple different types of lytic reactivation-inducing stimuli. Hagemeier SR, Barlow EA, Meng Q, Kenney SC. J Virol. 2012 Dec;86(24):13360-70. doi: 10.1128/JVI.01850-12. Epub 2012 Sep 26. PubMed |
| Low molecular weight dextran sulfate binds to human myoblasts and improves their survival after transplantation in mice. Laumonier T, Pradier A, Hoffmeyer P, Kindler V, Menetrey J. Cell Transplant. 2013;22(7):1213-26. doi: 10.3727/096368912X657224. Epub 2012 Oct 1. PubMed |
| Synergistic antitumor effects of endostar in combination with oxaliplatin via inhibition of HIF and CXCR4 in the colorectal cell line SW1116. Jin F, Ji H, Jia C, Brockmeier U, Hermann DM, Metzen E, Zhu Y, Chi B. PLoS One. 2012;7(10):e47161. doi: 10.1371/journal.pone.0047161. Epub 2012 Oct 10. PubMed |
| Defining Akt actions in muscle differentiation. Gardner S, Anguiano M, Rotwein P. Am J Physiol Cell Physiol. 2012 Dec 15;303(12):C1292-300. doi: 10.1152/ajpcell.00259.2012. Epub 2012 Oct 17. PubMed |
| Functional analysis of in-frame indel ARID1A mutations reveals new regulatory mechanisms of its tumor suppressor functions. Guan B, Gao M, Wu CH, Wang TL, Shih IeM. Neoplasia. 2012 Oct;14(10):986-93. PubMed |
| Influenza virus induces apoptosis via BAD-mediated mitochondrial dysregulation. Tran AT, Cortens JP, Du Q, Wilkins JA, Coombs KM. J Virol. 2013 Jan;87(2):1049-60. doi: 10.1128/JVI.02017-12. Epub 2012 Nov 7. PubMed |
| Loss of NF1 expression in human endothelial cells promotes autonomous proliferation and altered vascular morphogenesis. Bajaj A, Li QF, Zheng Q, Pumiglia K. PLoS One. 2012;7(11):e49222. doi: 10.1371/journal.pone.0049222. Epub 2012 Nov 7. PubMed |
| Impact of sustained RNAi-mediated suppression of cellular cofactor Tat-SF1 on HIV-1 replication in CD4+ T cells. Green VA, Arbuthnot P, Weinberg MS. Virol J. 2012 Nov 15;9:272. doi: 10.1186/1743-422X-9-272. PubMed |
| Comparison of mixed and lamellar coculture spatial arrangements for tissue engineering capillary networks in vitro. Peters EB, Christoforou N, Leong KW, Truskey GA. Tissue Eng Part A. 2013 Mar;19(5-6):697-706. doi: 10.1089/ten.tea.2011.0704. Epub 2012 Nov 21. PubMed |
| Role of early B-cell factor 1 (EBF1) in Hodgkin lymphoma. Bohle V, Doring C, Hansmann ML, Kuppers R. Leukemia. 2013 Mar;27(3):671-9. doi: 10.1038/leu.2012.280. Epub 2012 Oct 1. PubMed |
| Insulin inhibits cardiac mesoderm, not mesendoderm, formation during cardiac differentiation of human pluripotent stem cells and modulation of canonical Wnt signaling can rescue this inhibition. Lian X, Zhang J, Zhu K, Kamp TJ, Palecek SP. Stem Cells. 2013 Mar;31(3):447-57. doi: 10.1002/stem.1289. PubMed |
| Alpharetroviral vector-mediated gene therapy for X-CGD: functional correction and lack of aberrant splicing. Kaufmann KB, Brendel C, Suerth JD, Mueller-Kuller U, Chen-Wichmann L, Schwable J, Pahujani S, Kunkel H, Schambach A, Baum C, Grez M. Mol Ther. 2013 Mar;21(3):648-61. doi: 10.1038/mt.2012.249. Epub 2012 Dec 4. PubMed |
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| Role of C/EBPbeta-LAP and C/EBPbeta-LIP in early adipogenic differentiation of human white adipose-derived progenitors and at later stages in immature adipocytes. Lechner S, Mitterberger MC, Mattesich M, Zwerschke W. Differentiation. 2013 Jan;85(1-2):20-31. doi: 10.1016/j.diff.2012.11.001. Epub 2013 Jan 11. PubMed |
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| Identification of CDCP1 as a hypoxia-inducible factor 2alpha (HIF-2alpha) target gene that is associated with survival in clear cell renal cell carcinoma patients. Emerling BM, Benes CH, Poulogiannis G, Bell EL, Courtney K, Liu H, Choo-Wing R, Bellinger G, Tsukazawa KS, Brown V, Signoretti S, Soltoff SP, Cantley LC. Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3483-8. doi: 10.1073/pnas.1222435110. Epub 2013 Feb 1. PubMed |
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| The prolyl isomerase Pin1 acts synergistically with CDK2 to regulate the basal activity of estrogen receptor alpha in breast cancer. Lucchetti C, Caligiuri I, Toffoli G, Giordano A, Rizzolio F. PLoS One. 2013;8(2):e55355. doi: 10.1371/journal.pone.0055355. Epub 2013 Feb 4. PubMed |
| CD44 is involved in mineralization of dental pulp cells. Chen KL, Huang YY, Lung J, Yeh YY, Yuan K. J Endod. 2013 Mar;39(3):351-6. doi: 10.1016/j.joen.2012.11.043. Epub 2013 Jan 16. PubMed |
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| GRB2-mediated recruitment of THEMIS to LAT is essential for thymocyte development. Paster W, Brockmeyer C, Fu G, Simister PC, de Wet B, Martinez-Riano A, Hoerter JA, Feller SM, Wulfing C, Gascoigne NR, Acuto O. J Immunol. 2013 Apr 1;190(7):3749-56. doi: 10.4049/jimmunol.1203389. Epub 2013 Mar 4. PubMed |
| Canonical Wnt signaling induces BMP-4 to specify slow myofibrogenesis of fetal myoblasts. Kuroda K, Kuang S, Taketo MM, Rudnicki MA. Skelet Muscle. 2013 Mar 5;3(1):5. doi: 10.1186/2044-5040-3-5. PubMed |
| Hypoxia-inducible factor (HIF)-1alpha and CCN2 form a regulatory circuit in hypoxic nucleus pulposus cells: CCN2 suppresses HIF-1alpha level and transcriptional activity. Tran CM, Fujita N, Huang BL, Ong JR, Lyons KM, Shapiro IM, Risbud MV. J Biol Chem. 2013 May 3;288(18):12654-66. doi: 10.1074/jbc.M112.448860. Epub 2013 Mar 24. PubMed |
| The ULb' region of the human cytomegalovirus genome confers an increased requirement for the viral protein kinase UL97. Wang D, Li G, Schauflinger M, Nguyen CC, Hall ED, Yurochko AD, von Einem J, Kamil JP. J Virol. 2013 Jun;87(11):6359-76. doi: 10.1128/JVI.03477-12. Epub 2013 Mar 27. PubMed |
| Sigma-1 receptor regulates early steps of viral RNA replication at the onset of hepatitis C virus infection. Friesland M, Mingorance L, Chung J, Chisari FV, Gastaminza P. J Virol. 2013 Jun;87(11):6377-90. doi: 10.1128/JVI.03557-12. Epub 2013 Mar 27. PubMed |
| A systematic approach to the establishment and characterization of endothelial progenitor cells for gene therapy. Werling NJ, Thorpe R, Zhao Y. Hum Gene Ther Methods. 2013 Jun;24(3):171-84. doi: 10.1089/hgtb.2012.146. Epub 2013 Apr 30. PubMed |
| Nutrient-dependent phosphorylation channels lipid synthesis to regulate PPARalpha. Jensen-Urstad AP, Song H, Lodhi IJ, Funai K, Yin L, Coleman T, Semenkovich CF. J Lipid Res. 2013 Jul;54(7):1848-59. doi: 10.1194/jlr.M036103. Epub 2013 Apr 13. PubMed |
| DISC1-ATF4 transcriptional repression complex: dual regulation of the cAMP-PDE4 cascade by DISC1. Soda T, Frank C, Ishizuka K, Baccarella A, Park YU, Flood Z, Park SK, Sawa A, Tsai LH. Mol Psychiatry. 2013 Aug;18(8):898-908. doi: 10.1038/mp.2013.38. Epub 2013 Apr 16. PubMed |
| Inflammatory cytokines induce NOTCH signaling in nucleus pulposus cells: implications in intervertebral disc degeneration. Wang H, Tian Y, Wang J, Phillips KL, Binch AL, Dunn S, Cross A, Chiverton N, Zheng Z, Shapiro IM, Le Maitre CL, Risbud MV. J Biol Chem. 2013 Jun 7;288(23):16761-74. doi: 10.1074/jbc.M112.446633. Epub 2013 Apr 15. PubMed |
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| Lipid droplet-binding protein TIP47 regulates hepatitis C Virus RNA replication through interaction with the viral NS5A protein. Vogt DA, Camus G, Herker E, Webster BR, Tsou CL, Greene WC, Yen TS, Ott M. PLoS Pathog. 2013;9(4):e1003302. doi: 10.1371/journal.ppat.1003302. Epub 2013 Apr 11. PubMed |
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| Inflammatory cytokines associated with degenerative disc disease control aggrecanase-1 (ADAMTS-4) expression in nucleus pulposus cells through MAPK and NF-kappaB. Tian Y, Yuan W, Fujita N, Wang J, Wang H, Shapiro IM, Risbud MV. Am J Pathol. 2013 Jun;182(6):2310-21. doi: 10.1016/j.ajpath.2013.02.037. Epub 2013 Apr 17. PubMed |
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| Evidence for tankyrases as antineoplastic targets in lung cancer. Busch AM, Johnson KC, Stan RV, Sanglikar A, Ahmed Y, Dmitrovsky E, Freemantle SJ. BMC Cancer. 2013 Apr 28;13:211. doi: 10.1186/1471-2407-13-211. PubMed |
| Prox1 directly interacts with LSD1 and recruits the LSD1/NuRD complex to epigenetically co-repress CYP7A1 transcription. Ouyang H, Qin Y, Liu Y, Xie Y, Liu J. PLoS One. 2013 Apr 23;8(4):e62192. doi: 10.1371/journal.pone.0062192. Print 2013. PubMed |
| Efficacious proteasome/HDAC inhibitor combination therapy for primary effusion lymphoma. Bhatt S, Ashlock BM, Toomey NL, Diaz LA, Mesri EA, Lossos IS, Ramos JC. J Clin Invest. 2013 Jun;123(6):2616-28. doi: 10.1172/JCI64503. Epub 2013 May 1. PubMed |
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| Dyskeratosis congenita mutations in dyskerin SUMOylation consensus sites lead to impaired telomerase RNA accumulation and telomere defects. Brault ME, Lauzon C, Autexier C. Hum Mol Genet. 2013 Sep 1;22(17):3498-507. doi: 10.1093/hmg/ddt204. Epub 2013 May 8. PubMed |
| The B-cell-specific transcription factor and master regulator Pax5 promotes Epstein-Barr virus latency by negatively regulating the viral immediate early protein BZLF1. Raver RM, Panfil AR, Hagemeier SR, Kenney SC. J Virol. 2013 Jul;87(14):8053-63. doi: 10.1128/JVI.00546-13. Epub 2013 May 15. PubMed |
| Keratins control intercellular adhesion involving PKC-alpha-mediated desmoplakin phosphorylation. Kroger C, Loschke F, Schwarz N, Windoffer R, Leube RE, Magin TM. J Cell Biol. 2013 May 27;201(5):681-92. doi: 10.1083/jcb.201208162. Epub 2013 May 20. PubMed |
| Isolation, genetic manipulation, and transplantation of canine spermatogonial stem cells: progress toward transgenesis through the male germ-line. Harkey MA, Asano A, Zoulas ME, Torok-Storb B, Nagashima J, Travis A. Reproduction. 2013 Jun 14;146(1):75-90. doi: 10.1530/REP-13-0086. Print 2013 Jul. PubMed |
| Increased mutagenic joining of enzymatically-induced DNA double-strand breaks in high-charge and energy particle irradiated human cells. Li Z, Hudson FZ, Wang H, Wang Y, Bian Z, Murnane JP, Dynan WS. Radiat Res. 2013 Jul;180(1):17-24. doi: 10.1667/RR3332.1. Epub 2013 May 21. PubMed |
| Focal adhesion kinase is required for IGF-I-mediated growth of skeletal muscle cells via a TSC2/mTOR/S6K1-associated pathway. Crossland H, Kazi AA, Lang CH, Timmons JA, Pierre P, Wilkinson DJ, Smith K, Szewczyk NJ, Atherton PJ. Am J Physiol Endocrinol Metab. 2013 Jul 15;305(2):E183-93. doi: 10.1152/ajpendo.00541.2012. Epub 2013 May 21. PubMed |
| A robust strategy for negative selection of Cre-loxP recombination-based excision of transgenes in induced pluripotent stem cells. Chakraborty S, Christoforou N, Fattahi A, Herzog RW, Leong KW. PLoS One. 2013 May 22;8(5):e64342. doi: 10.1371/journal.pone.0064342. Print 2013. PubMed |
| Inhibiting Polo-like kinase 1 causes growth reduction and apoptosis in pediatric acute lymphoblastic leukemia cells. Hartsink-Segers SA, Exalto C, Allen M, Williamson D, Clifford SC, Horstmann M, Caron HN, Pieters R, Den Boer ML. Haematologica. 2013 Oct;98(10):1539-46. doi: 10.3324/haematol.2013.084434. Epub 2013 Jun 10. PubMed |
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| Chemerin neutralization blocks hematopoietic stem cell osteoclastogenesis. Muruganandan S, Dranse HJ, Rourke JL, McMullen NM, Sinal CJ. Stem Cells. 2013 Oct;31(10):2172-82. doi: 10.1002/stem.1450. PubMed |
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| A loss-of-function screen for phosphatases that regulate neurite outgrowth identifies PTPN12 as a negative regulator of TrkB tyrosine phosphorylation. Ambjorn M, Dubreuil V, Miozzo F, Nigon F, Moller B, Issazadeh-Navikas S, Berg J, Lees M, Sap J. PLoS One. 2013 Jun 13;8(6):e65371. doi: 10.1371/journal.pone.0065371. Print 2013. PubMed |
| Fibulin-2 is a driver of malignant progression in lung adenocarcinoma. Baird BN, Schliekelman MJ, Ahn YH, Chen Y, Roybal JD, Gill BJ, Mishra DK, Erez B, O'Reilly M, Yang Y, Patel M, Liu X, Thilaganathan N, Larina IV, Dickinson ME, West JL, Gibbons DL, Liu DD, Kim MP, Hicks JM, Wistuba II, Hanash SM, Kurie JM. PLoS One. 2013 Jun 10;8(6):e67054. doi: 10.1371/journal.pone.0067054. Print 2013. PubMed |
| Technical advance: actin CytoFRET, a novel FRET flow cytometry method for detection of actin dynamics in resting and activated T cell. Larbret F, Dubois N, Brau F, Guillemot E, Mahiddine K, Tartare-Deckert S, Verhasselt V, Deckert M. J Leukoc Biol. 2013 Sep;94(3):531-9. doi: 10.1189/jlb.0113022. Epub 2013 Jun 21. PubMed |
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| NGF upregulates the plasminogen activation inhibitor-1 in neurons via the calcineurin/NFAT pathway and the Down syndrome-related proteins DYRK1A and RCAN1 attenuate this effect. Stefos GC, Soppa U, Dierssen M, Becker W. PLoS One. 2013 Jun 25;8(6):e67470. doi: 10.1371/journal.pone.0067470. Print 2013. PubMed |
| Application of multiplexed kinase inhibitor beads to study kinome adaptations in drug-resistant leukemia. Cooper MJ, Cox NJ, Zimmerman EI, Dewar BJ, Duncan JS, Whittle MC, Nguyen TA, Jones LS, Ghose Roy S, Smalley DM, Kuan PF, Richards KL, Christopherson RI, Jin J, Frye SV, Johnson GL, Baldwin AS, Graves LM. PLoS One. 2013 Jun 24;8(6):e66755. doi: 10.1371/journal.pone.0066755. Print 2013. PubMed |
| The RNA-binding protein fused in sarcoma (FUS) functions downstream of poly(ADP-ribose) polymerase (PARP) in response to DNA damage. Mastrocola AS, Kim SH, Trinh AT, Rodenkirch LA, Tibbetts RS. J Biol Chem. 2013 Aug 23;288(34):24731-41. doi: 10.1074/jbc.M113.497974. Epub 2013 Jul 5. PubMed |
| The DNA damage checkpoint precedes activation of ARF in response to escalating oncogenic stress during tumorigenesis. Evangelou K, Bartkova J, Kotsinas A, Pateras IS, Liontos M, Velimezi G, Kosar M, Liloglou T, Trougakos IP, Dyrskjot L, Andersen CL, Papaioannou M, Drosos Y, Papafotiou G, Hodny Z, Sosa-Pineda B, Wu XR, Klinakis A, Orntoft T, Lukas J, Bartek J, Gorgoulis VG. Cell Death Differ. 2013 Nov;20(11):1485-97. doi: 10.1038/cdd.2013.76. Epub 2013 Jul 12. PubMed |
| The Pitx2:miR-200c/141:noggin pathway regulates Bmp signaling and ameloblast differentiation. Cao H, Jheon A, Li X, Sun Z, Wang J, Florez S, Zhang Z, McManus MT, Klein OD, Amendt BA. Development. 2013 Aug;140(16):3348-59. doi: 10.1242/dev.089193. Epub 2013 Jul 17. PubMed |
| Fine time course expression analysis identifies cascades of activation and repression and maps a putative regulator of mammalian sex determination. Munger SC, Natarajan A, Looger LL, Ohler U, Capel B. PLoS Genet. 2013;9(7):e1003630. doi: 10.1371/journal.pgen.1003630. Epub 2013 Jul 11. PubMed |
| Transcriptional repression of Bim by a novel YY1-RelA complex is essential for the survival and growth of Multiple Myeloma. Potluri V, Noothi SK, Vallabhapurapu SD, Yoon SO, Driscoll JJ, Lawrie CH, Vallabhapurapu S. PLoS One. 2013 Jul 10;8(7):e66121. doi: 10.1371/journal.pone.0066121. Print 2013. PubMed |
| Neuropathic and inflammatory pain are modulated by tuberoinfundibular peptide of 39 residues. Dimitrov EL, Kuo J, Kohno K, Usdin TB. Proc Natl Acad Sci U S A. 2013 Aug 6;110(32):13156-61. doi: 10.1073/pnas.1306342110. Epub 2013 Jul 22. PubMed |
| GRP78-targeting subtilase cytotoxin sensitizes cancer cells to photodynamic therapy. Firczuk M, Gabrysiak M, Barankiewicz J, Domagala A, Nowis D, Kujawa M, Jankowska-Steifer E, Wachowska M, Glodkowska-Mrowka E, Korsak B, Winiarska M, Golab J. Cell Death Dis. 2013 Jul 25;4:e741. doi: 10.1038/cddis.2013.265. PubMed |
| Impairment of endothelial-myocardial interaction increases the susceptibility of cardiomyocytes to ischemia/reperfusion injury. Leucker TM, Ge ZD, Procknow J, Liu Y, Shi Y, Bienengraeber M, Warltier DC, Kersten JR. PLoS One. 2013 Jul 22;8(7):e70088. doi: 10.1371/journal.pone.0070088. Print 2013. PubMed |
| pRb controls estrogen receptor alpha protein stability and activity. Caligiuri I, Toffoli G, Giordano A, Rizzolio F. Oncotarget. 2013 Jun;4(6):875-83. PubMed |
| Pid1 induces insulin resistance in both human and mouse skeletal muscle during obesity. Bonala S, McFarlane C, Ang J, Lim R, Lee M, Chua H, Lokireddy S, Sreekanth P, Leow MK, Meng KC, Shyong TE, Lee YS, Gluckman PD, Sharma M, Kambadur R. Mol Endocrinol. 2013 Sep;27(9):1518-35. doi: 10.1210/me.2013-1048. Epub 2013 Aug 8. PubMed |
| Length-dependent CTG.CAG triplet-repeat expansion in myotonic dystrophy patient-derived induced pluripotent stem cells. Du J, Campau E, Soragni E, Jespersen C, Gottesfeld JM. Hum Mol Genet. 2013 Dec 20;22(25):5276-87. doi: 10.1093/hmg/ddt386. Epub 2013 Aug 9. PubMed |
| Rab18 binds to hepatitis C virus NS5A and promotes interaction between sites of viral replication and lipid droplets. Salloum S, Wang H, Ferguson C, Parton RG, Tai AW. PLoS Pathog. 2013;9(8):e1003513. doi: 10.1371/journal.ppat.1003513. Epub 2013 Aug 1. PubMed |
| Knockdown of specific host factors protects against influenza virus-induced cell death. Tran AT, Rahim MN, Ranadheera C, Kroeker A, Cortens JP, Opanubi KJ, Wilkins JA, Coombs KM. Cell Death Dis. 2013 Aug 15;4:e769. doi: 10.1038/cddis.2013.296. PubMed |
| The zinc finger transcription factor ZXDC activates CCL2 gene expression by opposing BCL6-mediated repression. Ramsey JE, Fontes JD. Mol Immunol. 2013 Dec;56(4):768-80. doi: 10.1016/j.molimm.2013.07.001. Epub 2013 Aug 14. PubMed |
| Mesenchymal stem cell survival in the infarcted heart is enhanced by lentivirus vector-mediated heat shock protein 27 expression. McGinley LM, McMahon J, Stocca A, Duffy A, Flynn A, O'Toole D, O'Brien T. Hum Gene Ther. 2013 Oct;24(10):840-51. doi: 10.1089/hum.2011.009. PubMed |
| Noninvasive visualization of tumor growth in a human colorectal liver metastases xenograft model using bioluminescence in vivo imaging. Thalheimer A, Korb D, Bonicke L, Wiegering A, Muhling B, Schneider M, Koch S, Riedel SS, Germer CT, Beilhack A, Brandlein S, Otto C. J Surg Res. 2013 Nov;185(1):143-51. doi: 10.1016/j.jss.2013.03.024. Epub 2013 Mar 30. PubMed |
| FMRP regulates actin filament organization via the armadillo protein p0071. Nolze A, Schneider J, Keil R, Lederer M, Huttelmaier S, Kessels MM, Qualmann B, Hatzfeld M. RNA. 2013 Nov;19(11):1483-96. doi: 10.1261/rna.037945.112. Epub 2013 Sep 23. PubMed |
| Secreted Frizzled-related protein potentiation versus inhibition of Wnt3a/beta-catenin signaling. Xavier CP, Melikova M, Chuman Y, Uren A, Baljinnyam B, Rubin JS. Cell Signal. 2014 Jan;26(1):94-101. doi: 10.1016/j.cellsig.2013.09.016. Epub 2013 Sep 28. PubMed |
| Thalamic neuropeptide mediating the effects of nursing on lactation and maternal motivation. Cservenak M, Szabo ER, Bodnar I, Leko A, Palkovits M, Nagy GM, Usdin TB, Dobolyi A. Psychoneuroendocrinology. 2013 Dec;38(12):3070-84. doi: 10.1016/j.psyneuen.2013.09.004. Epub 2013 Sep 14. PubMed |
| Determination of the transforming activities of adenovirus oncogenes. Speiseder T, Nevels M, Dobner T. Methods Mol Biol. 2014;1089:105-15. doi: 10.1007/978-1-62703-679-5_8. PubMed |
| Role of JunB in adenosine A2B receptor-mediated vascular endothelial growth factor production. Ryzhov S, Biktasova A, Goldstein AE, Zhang Q, Biaggioni I, Dikov MM, Feoktistov I. Mol Pharmacol. 2014 Jan;85(1):62-73. doi: 10.1124/mol.113.088567. Epub 2013 Oct 17. PubMed |
| Doxycycline-regulated GDNF expression promotes axonal regeneration and functional recovery in transected peripheral nerve. Shakhbazau A, Mohanty C, Shcharbin D, Bryszewska M, Caminade AM, Majoral JP, Alant J, Midha R. J Control Release. 2013 Dec 28;172(3):841-51. doi: 10.1016/j.jconrel.2013.10.004. Epub 2013 Oct 17. PubMed |
| Depletion of a putatively druggable class of phosphatidylinositol kinases inhibits growth of p53-null tumors. Emerling BM, Hurov JB, Poulogiannis G, Tsukazawa KS, Choo-Wing R, Wulf GM, Bell EL, Shim HS, Lamia KA, Rameh LE, Bellinger G, Sasaki AT, Asara JM, Yuan X, Bullock A, Denicola GM, Song J, Brown V, Signoretti S, Cantley LC. Cell. 2013 Nov 7;155(4):844-57. doi: 10.1016/j.cell.2013.09.057. PubMed |
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| Reduced expression of the chromatin remodeling gene ARID1A enhances gastric cancer cell migration and invasion via downregulation of E-cadherin transcription. Yan HB, Wang XF, Zhang Q, Tang ZQ, Jiang YH, Fan HZ, Sun YH, Yang PY, Liu F. Carcinogenesis. 2014 Apr;35(4):867-76. doi: 10.1093/carcin/bgt398. Epub 2013 Nov 30. PubMed |
| The small GTPase Arf6 is essential for the Tram/Trif pathway in TLR4 signaling. Van Acker T, Eyckerman S, Vande Walle L, Gerlo S, Goethals M, Lamkanfi M, Bovijn C, Tavernier J, Peelman F. J Biol Chem. 2014 Jan 17;289(3):1364-76. doi: 10.1074/jbc.M113.499194. Epub 2013 Dec 2. PubMed |
| A potassium leak channel silences hyperactive neurons and ameliorates status epilepticus. Dey D, Eckle VS, Vitko I, Sullivan KA, Lasiecka ZM, Winckler B, Stornetta RL, Williamson JM, Kapur J, Perez-Reyes E. Epilepsia. 2014 Feb;55(2):203-13. doi: 10.1111/epi.12472. Epub 2013 Dec 2. PubMed |
| Visualizing of signaling proteins on endosomes utilizing knockdown and reconstitution approach. Jeoung M, Galperin E. Methods Enzymol. 2014;534:47-63. doi: 10.1016/B978-0-12-397926-1.00003-2. PubMed |
| Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging. Gomes AP, Price NL, Ling AJ, Moslehi JJ, Montgomery MK, Rajman L, White JP, Teodoro JS, Wrann CD, Hubbard BP, Mercken EM, Palmeira CM, de Cabo R, Rolo AP, Turner N, Bell EL, Sinclair DA. Cell. 2013 Dec 19;155(7):1624-38. doi: 10.1016/j.cell.2013.11.037. PubMed |
| Quantitation of DNA double-strand break resection intermediates in human cells. Zhou Y, Caron P, Legube G, Paull TT. Nucleic Acids Res. 2014 Feb;42(3):e19. doi: 10.1093/nar/gkt1309. Epub 2013 Dec 19. PubMed |
| Pore-exposed tyrosine residues of P-glycoprotein are important hydrogen-bonding partners for drugs. Donmez Cakil Y, Khunweeraphong N, Parveen Z, Schmid D, Artaker M, Ecker GF, Sitte HH, Pusch O, Stockner T, Chiba P. Mol Pharmacol. 2014 Mar;85(3):420-8. doi: 10.1124/mol.113.088526. Epub 2013 Dec 23. PubMed |
| mTOR target NDRG1 confers MGMT-dependent resistance to alkylating chemotherapy. Weiler M, Blaes J, Pusch S, Sahm F, Czabanka M, Luger S, Bunse L, Solecki G, Eichwald V, Jugold M, Hodecker S, Osswald M, Meisner C, Hielscher T, Rubmann P, Pfenning PN, Ronellenfitsch M, Kempf T, Schnolzer M, Abdollahi A, Lang F, Bendszus M, von Deimling A, Winkler F, Weller M, Vajkoczy P, Platten M, Wick W. Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):409-14. doi: 10.1073/pnas.1314469111. Epub 2013 Dec 23. PubMed |
| A human torque teno virus encodes a microRNA that inhibits interferon signaling. Kincaid RP, Burke JM, Cox JC, de Villiers EM, Sullivan CS. PLoS Pathog. 2013;9(12):e1003818. doi: 10.1371/journal.ppat.1003818. Epub 2013 Dec 19. PubMed |
| BET bromodomain inhibition triggers apoptosis of NF1-associated malignant peripheral nerve sheath tumors through Bim induction. Patel AJ, Liao CP, Chen Z, Liu C, Wang Y, Le LQ. Cell Rep. 2014 Jan 16;6(1):81-92. doi: 10.1016/j.celrep.2013.12.001. Epub 2013 Dec 27. PubMed |
| The FOS transcription factor family differentially controls trophoblast migration and invasion. Renaud SJ, Kubota K, Rumi MA, Soares MJ. J Biol Chem. 2014 Feb 21;289(8):5025-39. doi: 10.1074/jbc.M113.523746. Epub 2013 Dec 30. PubMed |
Tight control of hypoxia-inducible factor-alpha transient dynamics is essential for cell survival in hypoxia.
Bagnall J, Leedale J, Taylor SE, Spiller DG, White MR, Sharkey KJ, Bearon RN, See V.
J Biol Chem. 2014 Feb 28;289(9):5549-64. doi: 10.1074/jbc.M113.500405. Epub 2014 Jan 6.
PubMed
Associated Plasmids |
| Inhibition of stearoyl-coA desaturase selectively eliminates tumorigenic Nanog-positive cells: improving the safety of iPS cell transplantation to myocardium. Zhang L, Pan Y, Qin G, Chen L, Chatterjee TK, Weintraub NL, Tang Y. Cell Cycle. 2014;13(5):762-71. doi: 10.4161/cc.27677. Epub 2014 Jan 6. PubMed |
| microRNAs miR-27a and miR-27b directly regulate liver dihydropyrimidine dehydrogenase expression through two conserved binding sites. Offer SM, Butterfield GL, Jerde CR, Fossum CC, Wegner NJ, Diasio RB. Mol Cancer Ther. 2014 Mar;13(3):742-51. doi: 10.1158/1535-7163.MCT-13-0878. Epub 2014 Jan 8. PubMed |
| Dystrophin-deficient cardiomyocytes derived from human urine: new biologic reagents for drug discovery. Guan X, Mack DL, Moreno CM, Strande JL, Mathieu J, Shi Y, Markert CD, Wang Z, Liu G, Lawlor MW, Moorefield EC, Jones TN, Fugate JA, Furth ME, Murry CE, Ruohola-Baker H, Zhang Y, Santana LF, Childers MK. Stem Cell Res. 2014 Mar;12(2):467-80. doi: 10.1016/j.scr.2013.12.004. Epub 2013 Dec 23. PubMed |
| CCN2 suppresses catabolic effects of interleukin-1beta through alpha5beta1 and alphaVbeta3 integrins in nucleus pulposus cells: implications in intervertebral disc degeneration. Tran CM, Schoepflin ZR, Markova DZ, Kepler CK, Anderson DG, Shapiro IM, Risbud MV. J Biol Chem. 2014 Mar 14;289(11):7374-87. doi: 10.1074/jbc.M113.526111. Epub 2014 Jan 24. PubMed |
| All-trans-retinoic acid antagonizes the Hedgehog pathway by inducing patched. Busch AM, Galimberti F, Nehls KE, Roengvoraphoj M, Sekula D, Li B, Guo Y, Direnzo J, Fiering SN, Spinella MJ, Robbins DJ, Memoli VA, Freemantle SJ, Dmitrovsky E. Cancer Biol Ther. 2014 Apr;15(4):463-72. doi: 10.4161/cbt.27821. Epub 2014 Feb 4. PubMed |
| Oxysterol-binding protein is a phosphatidylinositol 4-kinase effector required for HCV replication membrane integrity and cholesterol trafficking. Wang H, Perry JW, Lauring AS, Neddermann P, De Francesco R, Tai AW. Gastroenterology. 2014 May;146(5):1373-85.e1-11. doi: 10.1053/j.gastro.2014.02.002. Epub 2014 Feb 8. PubMed |
| Importance of CD44 in the proliferation and mineralization of periodontal ligament cells. Yeh Y, Yang Y, Yuan K. J Periodontal Res. 2014 Dec;49(6):827-35. doi: 10.1111/jre.12170. Epub 2014 Feb 12. PubMed |
The PYRIN domain-only protein POP3 inhibits ALR inflammasomes and regulates responses to infection with DNA viruses.
Khare S, Ratsimandresy RA, de Almeida L, Cuda CM, Rellick SL, Misharin AV, Wallin MC, Gangopadhyay A, Forte E, Gottwein E, Perlman H, Reed JC, Greaves DR, Dorfleutner A, Stehlik C.
Nat Immunol. 2014 Apr;15(4):343-53. doi: 10.1038/ni.2829. Epub 2014 Feb 16.
PubMed
Associated Plasmids |
| deltaNp63 has a role in maintaining epithelial integrity in airway epithelium. Arason AJ, Jonsdottir HR, Halldorsson S, Benediktsdottir BE, Bergthorsson JT, Ingthorsson S, Baldursson O, Sinha S, Gudjonsson T, Magnusson MK. PLoS One. 2014 Feb 12;9(2):e88683. doi: 10.1371/journal.pone.0088683. eCollection 2014. PubMed |
| Design and analysis of site-specific single-strand nicking endonucleases for gene correction. Metzger MJ, Certo MT. Methods Mol Biol. 2014;1114:237-44. doi: 10.1007/978-1-62703-761-7_15. PubMed |
| Generation of transgene-free mouse induced pluripotent stem cells using an excisable lentiviral system. Varga E, Nemes C, Davis RP, Ujhelly O, Klincumhom N, Polgar Z, Muenthaisong S, Pirity MK, Dinnyes A. Exp Cell Res. 2014 Apr 1;322(2):335-44. doi: 10.1016/j.yexcr.2014.02.006. Epub 2014 Feb 18. PubMed |
| Inhibition of mTORC1 induces loss of E-cadherin through AKT/GSK-3beta signaling-mediated upregulation of E-cadherin repressor complexes in non-small cell lung cancer cells. Kim EY, Kim A, Kim SK, Kim HJ, Chang J, Ahn CM, Chang YS. Respir Res. 2014 Feb 26;15:26. doi: 10.1186/1465-9921-15-26. PubMed |
| Adipose tissue-derived stem cell secreted IGF-1 protects myoblasts from the negative effect of myostatin. Gehmert S, Wenzel C, Loibl M, Brockhoff G, Huber M, Krutsch W, Nerlich M, Gosau M, Klein S, Schreml S, Prantl L, Gehmert S. Biomed Res Int. 2014;2014:129048. doi: 10.1155/2014/129048. Epub 2014 Jan 23. PubMed |
| The Vac14-interaction network is linked to regulators of the endolysosomal and autophagic pathway. Schulze U, Vollenbroker B, Braun DA, Van Le T, Granado D, Kremerskothen J, Franzel B, Klosowski R, Barth J, Fufezan C, Wolters DA, Pavenstadt H, Weide T. Mol Cell Proteomics. 2014 Jun;13(6):1397-411. doi: 10.1074/mcp.M113.034108. Epub 2014 Feb 27. PubMed |
| RIP1 maintains DNA integrity and cell proliferation by regulating PGC-1alpha-mediated mitochondrial oxidative phosphorylation and glycolysis. Chen W, Wang Q, Bai L, Chen W, Wang X, Tellez CS, Leng S, Padilla MT, Nyunoya T, Belinsky SA, Lin Y. Cell Death Differ. 2014 Jul;21(7):1061-70. doi: 10.1038/cdd.2014.25. Epub 2014 Feb 28. PubMed |
| Inhibition of TGFbeta signaling increases direct conversion of fibroblasts to induced cardiomyocytes. Ifkovits JL, Addis RC, Epstein JA, Gearhart JD. PLoS One. 2014 Feb 26;9(2):e89678. doi: 10.1371/journal.pone.0089678. eCollection 2014. PubMed |
| Specific calcineurin targeting in macrophages confers resistance to inflammation via MKP-1 and p38. Escolano A, Martinez-Martinez S, Alfranca A, Urso K, Izquierdo HM, Delgado M, Martin F, Sabio G, Sancho D, Gomez-del Arco P, Redondo JM. EMBO J. 2014 May 16;33(10):1117-33. doi: 10.1002/embj.201386369. Epub 2014 Mar 3. PubMed |
| Cocaine disrupts histamine H3 receptor modulation of dopamine D1 receptor signaling: sigma1-D1-H3 receptor complexes as key targets for reducing cocaine's effects. Moreno E, Moreno-Delgado D, Navarro G, Hoffmann HM, Fuentes S, Rosell-Vilar S, Gasperini P, Rodriguez-Ruiz M, Medrano M, Mallol J, Cortes A, Casado V, Lluis C, Ferre S, Ortiz J, Canela E, McCormick PJ. J Neurosci. 2014 Mar 5;34(10):3545-58. doi: 10.1523/JNEUROSCI.4147-13.2014. PubMed |
| Production, purification and titration of a lentivirus-based vector for gene delivery purposes. Nasri M, Karimi A, Allahbakhshian Farsani M. Cytotechnology. 2014 Dec;66(6):1031-8. doi: 10.1007/s10616-013-9652-5. Epub 2014 Mar 6. PubMed |
| Inter-cellular exchange of cellular components via VE-cadherin-dependent trans-endocytosis. Sakurai T, Woolls MJ, Jin SW, Murakami M, Simons M. PLoS One. 2014 Mar 6;9(6):e90736. doi: 10.1371/journal.pone.0090736. eCollection 2014. PubMed |
| hCLE/C14orf166 associates with DDX1-HSPC117-FAM98B in a novel transcription-dependent shuttling RNA-transporting complex. Perez-Gonzalez A, Pazo A, Navajas R, Ciordia S, Rodriguez-Frandsen A, Nieto A. PLoS One. 2014 Mar 7;9(3):e90957. doi: 10.1371/journal.pone.0090957. eCollection 2014. PubMed |
| SAA1 polymorphisms are associated with variation in antiangiogenic and tumor-suppressive activities in nasopharyngeal carcinoma. Lung HL, Man OY, Yeung MC, Ko JM, Cheung AK, Law EW, Yu Z, Shuen WH, Tung E, Chan SH, Bangarusamy DK, Cheng Y, Yang X, Kan R, Phoon Y, Chan KC, Chua D, Kwong DL, Lee AW, Ji MF, Lung ML. Oncogene. 2015 Feb 12;34(7):878-89. doi: 10.1038/onc.2014.12. Epub 2014 Mar 10. PubMed |
| GP73 is upregulated by hepatitis C virus (HCV) infection and enhances HCV secretion. Hu L, Yao W, Wang F, Rong X, Peng T. PLoS One. 2014 Mar 7;9(3):e90553. doi: 10.1371/journal.pone.0090553. eCollection 2014. PubMed |
| The Hippo transducer TAZ interacts with the SWI/SNF complex to regulate breast epithelial lineage commitment. Skibinski A, Breindel JL, Prat A, Galvan P, Smith E, Rolfs A, Gupta PB, Labaer J, Kuperwasser C. Cell Rep. 2014 Mar 27;6(6):1059-72. doi: 10.1016/j.celrep.2014.02.038. Epub 2014 Mar 6. PubMed |
| Sphingosine Phosphate Lyase Regulates Murine Embryonic Stem Cell Proliferation and Pluripotency through an S1P/STAT3 Signaling Pathway. Smith GS, Kumar A, Saba JD. Biomolecules. 2013 Jun 24;3(3):351-368. PubMed |
| EMP1, a novel poor prognostic factor in pediatric leukemia regulates prednisolone resistance, cell proliferation, migration and adhesion. Aries IM, Jerchel IS, van den Dungen RE, van den Berk LC, Boer JM, Horstmann MA, Escherich G, Pieters R, den Boer ML. Leukemia. 2014 Sep;28(9):1828-37. doi: 10.1038/leu.2014.80. Epub 2014 Feb 20. PubMed |
| A protective antigen mutation increases the pH threshold of anthrax toxin receptor 2-mediated pore formation. Dennis MK, Mogridge J. Biochemistry. 2014 Apr 8;53(13):2166-71. doi: 10.1021/bi5000756. Epub 2014 Mar 25. PubMed |
| MiR-92a regulates viability and angiogenesis of endothelial cells under oxidative stress. Zhang L, Zhou M, Qin G, Weintraub NL, Tang Y. Biochem Biophys Res Commun. 2014 Apr 18;446(4):952-8. doi: 10.1016/j.bbrc.2014.03.035. Epub 2014 Mar 17. PubMed |
RPTPalpha controls epithelial adherens junctions, linking E-cadherin engagement to c-Src-mediated phosphorylation of cortactin.
Truffi M, Dubreuil V, Liang X, Vacaresse N, Nigon F, Han SP, Yap AS, Gomez GA, Sap J.
J Cell Sci. 2014 Jun 1;127(Pt 11):2420-32. doi: 10.1242/jcs.134379. Epub 2014 Mar 20.
PubMed
Associated Plasmids |
| Expressed glycosylphosphatidylinositol-anchored horseradish peroxidase identifies co-clustering molecules in individual lipid raft domains. Miyagawa-Yamaguchi A, Kotani N, Honke K. PLoS One. 2014 Mar 26;9(3):e93054. doi: 10.1371/journal.pone.0093054. eCollection 2014. PubMed |
| Evolutionary and molecular facts link the WWC protein family to Hippo signaling. Wennmann DO, Schmitz J, Wehr MC, Krahn MP, Koschmal N, Gromnitza S, Schulze U, Weide T, Chekuri A, Skryabin BV, Gerke V, Pavenstadt H, Duning K, Kremerskothen J. Mol Biol Evol. 2014 Jul;31(7):1710-23. doi: 10.1093/molbev/msu115. Epub 2014 Mar 27. PubMed |
| Myostatin knockdown and its effect on myogenic gene expression program in stably transfected goat myoblasts. Patel AK, Tripathi AK, Patel UA, Shah RK, Joshi CG. In Vitro Cell Dev Biol Anim. 2014 Aug;50(7):587-96. doi: 10.1007/s11626-014-9743-4. Epub 2014 Mar 28. PubMed |
| Activation of neural cell fate programs toward direct conversion of adult human fibroblasts into tri-potent neural progenitors using OCT-4. Mitchell RR, Szabo E, Benoit YD, Case DT, Mechael R, Alamilla J, Lee JH, Fiebig-Comyn A, Gillespie DC, Bhatia M. Stem Cells Dev. 2014 Aug 15;23(16):1937-46. doi: 10.1089/scd.2014.0023. Epub 2014 May 13. PubMed |
| Generation and characterization of induced pluripotent stem cells from Aid-deficient mice. Shimamoto R, Amano N, Ichisaka T, Watanabe A, Yamanaka S, Okita K. PLoS One. 2014 Apr 9;9(4):e94735. doi: 10.1371/journal.pone.0094735. eCollection 2014. PubMed |
| CDK2-dependent phosphorylation of Suv39H1 is involved in control of heterochromatin replication during cell cycle progression. Park SH, Yu SE, Chai YG, Jang YK. Nucleic Acids Res. 2014 Jun;42(10):6196-207. doi: 10.1093/nar/gku263. Epub 2014 Apr 11. PubMed |
| Evaluation of apoptosis induction by concomitant inhibition of MEK, mTOR, and Bcl-2 in human acute myelogenous leukemia cells. Zhang W, Ruvolo VR, Gao C, Zhou L, Bornmann W, Tsao T, Schober WD, Smith P, Guichard S, Konopleva M, Andreeff M. Mol Cancer Ther. 2014 Jul;13(7):1848-59. doi: 10.1158/1535-7163.MCT-13-0576. Epub 2014 Apr 16. PubMed |
| Pancreatic beta-cell failure mediated by mTORC1 hyperactivity and autophagic impairment. Bartolome A, Kimura-Koyanagi M, Asahara S, Guillen C, Inoue H, Teruyama K, Shimizu S, Kanno A, Garcia-Aguilar A, Koike M, Uchiyama Y, Benito M, Noda T, Kido Y. Diabetes. 2014 Sep;63(9):2996-3008. doi: 10.2337/db13-0970. Epub 2014 Apr 16. PubMed |
| Transdifferentiation of mouse fibroblasts and hepatocytes to functional neurons. Marro S, Yang N. Methods Mol Biol. 2014;1150:237-46. doi: 10.1007/978-1-4939-0512-6_16. PubMed |
| "Triplet" polycistronic vectors encoding Gata4, Mef2c, and Tbx5 enhances postinfarct ventricular functional improvement compared with singlet vectors. Mathison M, Singh VP, Gersch RP, Ramirez MO, Cooney A, Kaminsky SM, Chiuchiolo MJ, Nasser A, Yang J, Crystal RG, Rosengart TK. J Thorac Cardiovasc Surg. 2014 Oct;148(4):1656-1664.e2. doi: 10.1016/j.jtcvs.2014.03.033. Epub 2014 Mar 27. PubMed |
| Increased genomic integrity of an improved protein-based mouse induced pluripotent stem cell method compared with current viral-induced strategies. Park H, Kim D, Kim CH, Mills RE, Chang MY, Iskow RC, Ko S, Moon JI, Choi HW, Man Yoo PS, Do JT, Han MJ, Lee EG, Jung JK, Zhang C, Lanza R, Kim KS. Stem Cells Transl Med. 2014 May;3(5):599-609. doi: 10.5966/sctm.2013-0149. Epub 2014 Apr 24. PubMed |
| Tissue-engineered cartilage with inducible and tunable immunomodulatory properties. Glass KA, Link JM, Brunger JM, Moutos FT, Gersbach CA, Guilak F. Biomaterials. 2014 Jul;35(22):5921-31. doi: 10.1016/j.biomaterials.2014.03.073. Epub 2014 Apr 22. PubMed |
| Murine norovirus: propagation, quantification, and genetic manipulation. Hwang S, Alhatlani B, Arias A, Caddy SL, Christodoulou C, Cunha JB, Emmott E, Gonzalez-Hernandez M, Kolawole A, Lu J, Rippinger C, Sorgeloos F, Thorne L, Vashist S, Goodfellow I, Wobus CE. Curr Protoc Microbiol. 2014 May 1;33:15K.2.1-61. doi: 10.1002/9780471729259.mc15k02s33. PubMed |
| Impact of an altered PROX1 expression on clinicopathology, prognosis and progression in renal cell carcinoma. Lv T, Liu Y, Zhang J, Xu L, Zhu Y, Yin H, An H, Lin Z, Xie Y, Chen L. PLoS One. 2014 May 5;9(5):e95996. doi: 10.1371/journal.pone.0095996. eCollection 2014. PubMed |
| Polymerase I and transcript release factor (PTRF) regulates adipocyte differentiation and determines adipose tissue expandability. Perez-Diaz S, Johnson LA, DeKroon RM, Moreno-Navarrete JM, Alzate O, Fernandez-Real JM, Maeda N, Arbones-Mainar JM. FASEB J. 2014 Aug;28(8):3769-79. doi: 10.1096/fj.14-251165. Epub 2014 May 8. PubMed |
| Long intergenic non-coding RNA HOTAIRM1 regulates cell cycle progression during myeloid maturation in NB4 human promyelocytic leukemia cells. Zhang X, Weissman SM, Newburger PE. RNA Biol. 2014;11(6):777-87. Epub 2014 Apr 24. PubMed |
| SIRT2 induces the checkpoint kinase BubR1 to increase lifespan. North BJ, Rosenberg MA, Jeganathan KB, Hafner AV, Michan S, Dai J, Baker DJ, Cen Y, Wu LE, Sauve AA, van Deursen JM, Rosenzweig A, Sinclair DA. EMBO J. 2014 Jul 1;33(13):1438-53. doi: 10.15252/embj.201386907. Epub 2014 May 12. PubMed |
| Quantitative proteomic analysis of host-virus interactions reveals a role for Golgi brefeldin A resistance factor 1 (GBF1) in dengue infection. Carpp LN, Rogers RS, Moritz RL, Aitchison JD. Mol Cell Proteomics. 2014 Nov;13(11):2836-54. doi: 10.1074/mcp.M114.038984. Epub 2014 May 22. PubMed |
| MST4 promotes hepatocellular carcinoma epithelial-mesenchymal transition and metastasis via activation of the p-ERK pathway. Lin ZH, Wang L, Zhang JB, Liu Y, Li XQ, Guo L, Zhang B, Zhu WW, Ye QH. Int J Oncol. 2014 Aug;45(2):629-40. doi: 10.3892/ijo.2014.2455. Epub 2014 May 22. PubMed |
| FIH-1-Mint3 axis does not control HIF-1 transcriptional activity in nucleus pulposus cells. Hirose Y, Johnson ZI, Schoepflin ZR, Markova DZ, Chiba K, Toyama Y, Shapiro IM, Risbud MV. J Biol Chem. 2014 Jul 25;289(30):20594-605. PubMed |
| Nrf2, a regulator of the proteasome, controls self-renewal and pluripotency in human embryonic stem cells. Jang J, Wang Y, Kim HS, Lalli MA, Kosik KS. Stem Cells. 2014 Oct;32(10):2616-25. doi: 10.1002/stem.1764. PubMed |
| Autophagy promotes resistance to photodynamic therapy-induced apoptosis selectively in colorectal cancer stem-like cells. Wei MF, Chen MW, Chen KC, Lou PJ, Lin SY, Hung SC, Hsiao M, Yao CJ, Shieh MJ. Autophagy. 2014 Jul;10(7):1179-92. doi: 10.4161/auto.28679. Epub 2014 Apr 29. PubMed |
| Molecular neuroimaging of post-injury plasticity. Jouroukhin Y, Nonyane BA, Gilad AA, Pelled G. J Mol Neurosci. 2014 Dec;54(4):630-8. doi: 10.1007/s12031-014-0347-y. Epub 2014 Jun 10. PubMed |
| Sorting cells for basal and induced autophagic flux by quantitative ratiometric flow cytometry. Gump JM, Thorburn A. Autophagy. 2014 Jul;10(7):1327-34. doi: 10.4161/auto.29394. Epub 2014 Jun 5. PubMed |
| Inhibition of glutathione peroxidase mediates the collateral sensitivity of multidrug-resistant cells to tiopronin. Hall MD, Marshall TS, Kwit AD, Miller Jenkins LM, Dulcey AE, Madigan JP, Pluchino KM, Goldsborough AS, Brimacombe KR, Griffiths GL, Gottesman MM. J Biol Chem. 2014 Aug 1;289(31):21473-89. doi: 10.1074/jbc.M114.581702. Epub 2014 Jun 14. PubMed |
| 17beta-estradiol regulates giant vesicle formation via estrogen receptor-alpha in human breast cancer cells. Wright PK, Jones SB, Ardern N, Ward R, Clarke RB, Sotgia F, Lisanti MP, Landberg G, Lamb R. Oncotarget. 2014 May 30;5(10):3055-65. PubMed |
| The prolyl peptidases PRCP/PREP regulate IRS-1 stability critical for rapamycin-induced feedback activation of PI3K and AKT. Duan L, Ying G, Danzer B, Perez RE, Shariat-Madar Z, Levenson VV, Maki CG. J Biol Chem. 2014 Aug 1;289(31):21694-705. doi: 10.1074/jbc.M114.550038. Epub 2014 Jun 16. PubMed |
| IL-17 and GM-CSF expression are antagonistically regulated by human T helper cells. Noster R, Riedel R, Mashreghi MF, Radbruch H, Harms L, Haftmann C, Chang HD, Radbruch A, Zielinski CE. Sci Transl Med. 2014 Jun 18;6(241):241ra80. doi: 10.1126/scitranslmed.3008706. PubMed |
| Presynaptic clathrin levels are a limiting factor for synaptic transmission. Lopez-Murcia FJ, Royle SJ, Llobet A. J Neurosci. 2014 Jun 18;34(25):8618-29. doi: 10.1523/JNEUROSCI.5081-13.2014. PubMed |
Generation of mouse models of myeloid malignancy with combinatorial genetic lesions using CRISPR-Cas9 genome editing.
Heckl D, Kowalczyk MS, Yudovich D, Belizaire R, Puram RV, McConkey ME, Thielke A, Aster JC, Regev A, Ebert BL.
Nat Biotechnol. 2014 Jun 22. doi: 10.1038/nbt.2951.
PubMed
Associated Plasmids |
| Assessing the efficacy of nano- and micro-sized magnetic particles as contrast agents for MRI cell tracking. Taylor A, Herrmann A, Moss D, See V, Davies K, Williams SR, Murray P. PLoS One. 2014 Jun 24;9(6):e100259. doi: 10.1371/journal.pone.0100259. eCollection 2014. PubMed |
| Quantitative phosphoproteomics reveals novel phosphorylation events in insulin signaling regulated by protein phosphatase 1 regulatory subunit 12A. Zhang X, Ma D, Caruso M, Lewis M, Qi Y, Yi Z. J Proteomics. 2014 Sep 23;109:63-75. doi: 10.1016/j.jprot.2014.06.010. Epub 2014 Jun 25. PubMed |
| PKCzeta and PKMzeta are overexpressed in TCF3-rearranged paediatric acute lymphoblastic leukaemia and are associated with increased thiopurine sensitivity. Hartsink-Segers SA, Beaudoin JJ, Luijendijk MW, Exalto C, Pieters R, Den Boer ML. Leukemia. 2015 Feb;29(2):304-11. doi: 10.1038/leu.2014.210. Epub 2014 Jul 3. PubMed |
| ERbeta- and prostaglandin E2-regulated pathways integrate cell proliferation via Ras-like and estrogen-regulated growth inhibitor in endometriosis. Monsivais D, Dyson MT, Yin P, Coon JS, Navarro A, Feng G, Malpani SS, Ono M, Ercan CM, Wei JJ, Pavone ME, Su E, Bulun SE. Mol Endocrinol. 2014 Aug;28(8):1304-15. doi: 10.1210/me.2013-1421. Epub 2014 Jul 3. PubMed |
| Live cell imaging of primary rat neonatal cardiomyocytes following adenoviral and lentiviral transduction using confocal spinning disk microscopy. Sakurai T, Lanahan A, Woolls MJ, Li N, Tirziu D, Murakami M. J Vis Exp. 2014 Jun 24;(88):e51666. doi: 10.3791/51666. PubMed |
| Sirtuin1 (Sirt1) promotes cortical bone formation by preventing beta-catenin sequestration by FoxO transcription factors in osteoblast progenitors. Iyer S, Han L, Bartell SM, Kim HN, Gubrij I, de Cabo R, O'Brien CA, Manolagas SC, Almeida M. J Biol Chem. 2014 Aug 29;289(35):24069-78. doi: 10.1074/jbc.M114.561803. Epub 2014 Jul 7. PubMed |
| Par3-mInsc and Galphai3 cooperate to promote oriented epidermal cell divisions through LGN. Williams SE, Ratliff LA, Postiglione MP, Knoblich JA, Fuchs E. Nat Cell Biol. 2014 Aug;16(8):758-69. doi: 10.1038/ncb3001. Epub 2014 Jul 13. PubMed |
| CREB SUMOylation by the E3 ligase PIAS1 enhances spatial memory. Chen YC, Hsu WL, Ma YL, Tai DJ, Lee EH. J Neurosci. 2014 Jul 16;34(29):9574-89. doi: 10.1523/JNEUROSCI.4302-13.2014. PubMed |
| Differential requirements of arrestin-3 and clathrin for ligand-dependent and -independent internalization of human G protein-coupled receptor 40. Qian J, Wu C, Chen X, Li X, Ying G, Jin L, Ma Q, Li G, Shi Y, Zhang G, Zhou N. Cell Signal. 2014 Nov;26(11):2412-23. doi: 10.1016/j.cellsig.2014.07.019. Epub 2014 Jul 16. PubMed |
| Oncogenic role of Merlin/NF2 in glioblastoma. Guerrero PA, Yin W, Camacho L, Marchetti D. Oncogene. 2015 May 14;34(20):2621-30. doi: 10.1038/onc.2014.185. Epub 2014 Jul 21. PubMed |
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| Tumor necrosis factor-alpha- and interleukin-1beta-dependent matrix metalloproteinase-3 expression in nucleus pulposus cells requires cooperative signaling via syndecan 4 and mitogen-activated protein kinase-NF-kappaB axis: implications in inflammatory disc disease. Wang X, Wang H, Yang H, Li J, Cai Q, Shapiro IM, Risbud MV. Am J Pathol. 2014 Sep;184(9):2560-72. doi: 10.1016/j.ajpath.2014.06.006. Epub 2014 Jul 22. PubMed |
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| CD47 agonist peptides induce programmed cell death in refractory chronic lymphocytic leukemia B cells via PLCgamma1 activation: evidence from mice and humans. Martinez-Torres AC, Quiney C, Attout T, Boullet H, Herbi L, Vela L, Barbier S, Chateau D, Chapiro E, Nguyen-Khac F, Davi F, Le Garff-Tavernier M, Moumne R, Sarfati M, Karoyan P, Merle-Beral H, Launay P, Susin SA. PLoS Med. 2015 Mar 3;12(3):e1001796. doi: 10.1371/journal.pmed.1001796. eCollection 2015 Mar. PubMed |
| DNA damage shifts circadian clock time via Hausp-dependent Cry1 stabilization. Papp SJ, Huber AL, Jordan SD, Kriebs A, Nguyen M, Moresco JJ, Yates JR, Lamia KA. Elife. 2015 Mar 10;4. doi: 10.7554/eLife.04883. PubMed |
Plexin-B2 promotes invasive growth of malignant glioma.
Le AP, Huang Y, Pingle SC, Kesari S, Wang H, Yong RL, Zou H, Friedel RH.
Oncotarget. 2015 Mar 30;6(9):7293-304.
PubMed
Associated Plasmids |
| NIK is required for NF-kappaB-mediated induction of BAG3 upon inhibition of constitutive protein degradation pathways. Rapino F, Abhari BA, Jung M, Fulda S. Cell Death Dis. 2015 Mar 12;6:e1692. doi: 10.1038/cddis.2014.584. PubMed |
| Selective Distal Enhancer Control of the Mmp13 Gene Identified through Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR) Genomic Deletions. Meyer MB, Benkusky NA, Pike JW. J Biol Chem. 2015 Apr 24;290(17):11093-107. doi: 10.1074/jbc.M115.648394. Epub 2015 Mar 15. PubMed |
| IFI44 suppresses HIV-1 LTR promoter activity and facilitates its latency. Power D, Santoso N, Dieringer M, Yu J, Huang H, Simpson S, Seth I, Miao H, Zhu J. Virology. 2015 Jul;481:142-50. doi: 10.1016/j.virol.2015.02.046. Epub 2015 Mar 14. PubMed |
| miR-191 promotes tumorigenesis of human colorectal cancer through targeting C/EBPbeta. Zhang XF, Li KK, Gao L, Li SZ, Chen K, Zhang JB, Wang D, Tu RF, Zhang JX, Tao KX, Wang G, Zhang XD. Oncotarget. 2015 Feb 28;6(6):4144-58. PubMed |
| Modeling and study of the mechanism of dilated cardiomyopathy using induced pluripotent stem cells derived from individuals with Duchenne muscular dystrophy. Lin B, Li Y, Han L, Kaplan AD, Ao Y, Kalra S, Bett GC, Rasmusson RL, Denning C, Yang L. Dis Model Mech. 2015 May;8(5):457-66. doi: 10.1242/dmm.019505. Epub 2015 Mar 19. PubMed |
| Borna disease virus phosphoprotein modulates epigenetic signaling in neurons to control viral replication. Bonnaud EM, Szelechowski M, Betourne A, Foret C, Thouard A, Gonzalez-Dunia D, Malnou CE. J Virol. 2015 Jun;89(11):5996-6008. doi: 10.1128/JVI.00454-15. Epub 2015 Mar 25. PubMed |
| Sustained regeneration of high-volume adipose tissue for breast reconstruction using computer aided design and biomanufacturing. Chhaya MP, Melchels FP, Holzapfel BM, Baldwin JG, Hutmacher DW. Biomaterials. 2015 Jun;52:551-60. doi: 10.1016/j.biomaterials.2015.01.025. Epub 2015 Mar 18. PubMed |
| CCM2-CCM3 interaction stabilizes their protein expression and permits endothelial network formation. Draheim KM, Li X, Zhang R, Fisher OS, Villari G, Boggon TJ, Calderwood DA. J Cell Biol. 2015 Mar 30;208(7):987-1001. doi: 10.1083/jcb.201407129. PubMed |
| TGF-beta suppression of HBV RNA through AID-dependent recruitment of an RNA exosome complex. Liang G, Liu G, Kitamura K, Wang Z, Chowdhury S, Monjurul AM, Wakae K, Koura M, Shimadu M, Kinoshita K, Muramatsu M. PLoS Pathog. 2015 Apr 2;11(4):e1004780. doi: 10.1371/journal.ppat.1004780. eCollection 2015 Apr. PubMed |
| Caveolin-1 is transcribed from a hypermethylated promoter to mediate colonocyte differentiation and apoptosis. Dasgupta N, Kumar Thakur B, Ta A, Das S. Exp Cell Res. 2015 Jun 10;334(2):323-36. doi: 10.1016/j.yexcr.2015.03.020. Epub 2015 Apr 1. PubMed |
Rationally Designed MicroRNA-Based Genetic Classifiers Target Specific Neurons in the Brain.
Sayeg MK, Weinberg BH, Cha SS, Goodloe M, Wong WW, Han X.
ACS Synth Biol. 2015 Apr 13.
PubMed
Associated Plasmids |
| Repeated ER-endosome contacts promote endosome translocation and neurite outgrowth. Raiborg C, Wenzel EM, Pedersen NM, Olsvik H, Schink KO, Schultz SW, Vietri M, Nisi V, Bucci C, Brech A, Johansen T, Stenmark H. Nature. 2015 Apr 9;520(7546):234-8. doi: 10.1038/nature14359. PubMed |
| Latent transforming growth factor-beta binding proteins (LTBP-1 and LTBP-2) and gingiva keratinization. Chiang MS, Yang JR, Liao SC, Hsu CC, Hsu CW, Yuan K. Oral Dis. 2015 Apr 10. doi: 10.1111/odi.12344. PubMed |
| Methods of Reprogramming to Induced Pluripotent Stem Cell Associated with Chromosomal Integrity and Delineation of a Chromosome 5q Candidate Region for Growth Advantage. Sobol M, Raykova D, Cavelier L, Khalfallah A, Schuster J, Dahl N. Stem Cells Dev. 2015 Sep 1;24(17):2032-40. doi: 10.1089/scd.2015.0061. Epub 2015 May 18. PubMed |
| A pooled shRNA screen for regulators of primary mammary stem and progenitor cells identifies roles for Asap1 and Prox1. Sheridan JM, Ritchie ME, Best SA, Jiang K, Beck TJ, Vaillant F, Liu K, Dickins RA, Smyth GK, Lindeman GJ, Visvader JE. BMC Cancer. 2015 Apr 3;15:221. doi: 10.1186/s12885-015-1187-z. PubMed |
| alpha6beta1- and alphaV-integrins are required for long-term self-renewal of murine embryonic stem cells in the absence of LIF. Cattavarayane S, Palovuori R, Tanjore Ramanathan J, Manninen A. BMC Cell Biol. 2015 Feb 27;16:3. doi: 10.1186/s12860-015-0051-y. PubMed |
| Loss of GM130 in breast cancer cells and its effects on cell migration, invasion and polarity. Baschieri F, Uetz-von Allmen E, Legler DF, Farhan H. Cell Cycle. 2015;14(8):1139-47. doi: 10.1080/15384101.2015.1007771. PubMed |
| Quantification of cell fusion events human breast cancer cells and breast epithelial cells using a Cre-LoxP-based double fluorescence reporter system. Mohr M, Tosun S, Arnold WH, Edenhofer F, Zanker KS, Dittmar T. Cell Mol Life Sci. 2015 Apr 22. PubMed |
| Single-step cloning-screening method: a new tool for developing and studying high-titer viral vector producer cells. Rodrigues AF, Formas-Oliveira AS, Guerreiro MR, Tomas HA, Alves PM, Coroadinha AS. Gene Ther. 2015 Sep;22(9):685-95. doi: 10.1038/gt.2015.44. Epub 2015 May 4. PubMed |
| Viral-mediated Labeling and Transplantation of Medial Ganglionic Eminence (MGE) Cells for In Vivo Studies. Vogt D, Wu PR, Sorrells SF, Arnold C, Alvarez-Buylla A, Rubenstein JL. J Vis Exp. 2015 Apr 23;(98). doi: 10.3791/52740. PubMed |
| An alternative pluripotent state confers interspecies chimaeric competency. Wu J, Okamura D, Li M, Suzuki K, Luo C, Ma L, He Y, Li Z, Benner C, Tamura I, Krause MN, Nery JR, Du T, Zhang Z, Hishida T, Takahashi Y, Aizawa E, Kim NY, Lajara J, Guillen P, Campistol JM, Esteban CR, Ross PJ, Saghatelian A, Ren B, Ecker JR, Izpisua Belmonte JC. Nature. 2015 May 21;521(7552):316-21. doi: 10.1038/nature14413. Epub 2015 May 6. PubMed |
| Overexpression of the Promigratory and Prometastatic PTK7 Receptor Is Associated with an Adverse Clinical Outcome in Colorectal Cancer. Lhoumeau AC, Martinez S, Boher JM, Monges G, Castellano R, Goubard A, Doremus M, Poizat F, Lelong B, de Chaisemartin C, Bardin F, Viens P, Raoul JL, Prebet T, Aurrand-Lions M, Borg JP, Goncalves A. PLoS One. 2015 May 11;10(5):e0123768. doi: 10.1371/journal.pone.0123768. eCollection 2015. PubMed |
| Inhibition of histone methyltransferases SUV39H1 and G9a leads to neuroprotection in an in vitro model of cerebral ischemia. Schweizer S, Harms C, Lerch H, Flynn J, Hecht J, Yildirim F, Meisel A, Marschenz S. J Cereb Blood Flow Metab. 2015 May 13. doi: 10.1038/jcbfm.2015.99. PubMed |
| Reduced efficiency of sarcolipin-dependent respiration in myocytes from humans with severe obesity. Paran CW, Verkerke AR, Heden TD, Park S, Zou K, Lawson HA, Song H, Turk J, Houmard JA, Funai K. Obesity (Silver Spring). 2015 Jul;23(7):1440-9. doi: 10.1002/oby.21123. Epub 2015 May 13. PubMed |
| Mechanisms of clonal evolution in childhood acute lymphoblastic leukemia. Swaminathan S, Klemm L, Park E, Papaemmanuil E, Ford A, Kweon SM, Trageser D, Hasselfeld B, Henke N, Mooster J, Geng H, Schwarz K, Kogan SC, Casellas R, Schatz DG, Lieber MR, Greaves MF, Muschen M. Nat Immunol. 2015 Jul;16(7):766-74. doi: 10.1038/ni.3160. Epub 2015 May 18. PubMed |
| Regulation of autophagic cell death by glycogen synthase kinase-3beta in adult hippocampal neural stem cells following insulin withdrawal. Ha S, Ryu HY, Chung KM, Baek SH, Kim EK, Yu SW. Mol Brain. 2015 May 19;8:30. doi: 10.1186/s13041-015-0119-9. PubMed |
| The schizophrenia risk gene product miR-137 alters presynaptic plasticity. Siegert S, Seo J, Kwon EJ, Rudenko A, Cho S, Wang W, Flood Z, Martorell AJ, Ericsson M, Mungenast AE, Tsai LH. Nat Neurosci. 2015 Jul;18(7):1008-16. doi: 10.1038/nn.4023. Epub 2015 May 25. PubMed |
| Generation of X-CGD cells for vector evaluation from healthy donor CD34(+) HSCs by shRNA-mediated knock down of gp91(phox). Brendel C, Kaufmann KB, Krattenmacher A, Pahujani S, Grez M. Mol Ther Methods Clin Dev. 2014 Aug 27;1:14037. doi: 10.1038/mtm.2014.37. eCollection 2014. PubMed |
| Comparative analysis of lentiviral vectors and modular protein nanovectors for traumatic brain injury gene therapy. Negro-Demontel ML, Saccardo P, Giacomini C, Yanez-Munoz RJ, Ferrer-Miralles N, Vazquez E, Villaverde A, Peluffo H. Mol Ther Methods Clin Dev. 2014 Oct 15;1:14047. doi: 10.1038/mtm.2014.47. eCollection 2014. PubMed |
| Death of Neurons following Injury Requires Conductive Neuronal Gap Junction Channels but Not a Specific Connexin. Fontes JD, Ramsey J, Polk JM, Koop A, Denisova JV, Belousov AB. PLoS One. 2015 May 27;10(5):e0125395. doi: 10.1371/journal.pone.0125395. eCollection 2015. PubMed |
| Coronary Artery Disease Associated Transcription Factor TCF21 Regulates Smooth Muscle Precursor Cells That Contribute to the Fibrous Cap. Nurnberg ST, Cheng K, Raiesdana A, Kundu R, Miller CL, Kim JB, Arora K, Carcamo-Oribe I, Xiong Y, Tellakula N, Nanda V, Murthy N, Boisvert WA, Hedin U, Perisic L, Aldi S, Maegdefessel L, Pjanic M, Owens GK, Tallquist MD, Quertermous T. PLoS Genet. 2015 May 28;11(5):e1005155. doi: 10.1371/journal.pgen.1005155. eCollection 2015 May. PubMed |
| Human Induced Pluripotent Stem Cell-Derived Microvesicles Transmit RNAs and Proteins to Recipient Mature Heart Cells Modulating Cell Fate and Behavior. Bobis-Wozowicz S, Kmiotek K, Sekula M, Kedracka-Krok S, Kamycka E, Adamiak M, Jankowska U, Madetko-Talowska A, Sarna M, Bik-Multanowski M, Kolcz J, Boruczkowski D, Madeja Z, Dawn B, Zuba-Surma EK. Stem Cells. 2015 Jun 1. doi: 10.1002/stem.2078. PubMed |
| E2F1-Mediated Induction of NFYB Attenuates Apoptosis via Joint Regulation of a Pro-Survival Transcriptional Program. Jiang X, Nevins JR, Shats I, Chi JT. PLoS One. 2015 Jun 3;10(6):e0127951. doi: 10.1371/journal.pone.0127951. eCollection 2015. PubMed |
Akt signaling dynamics in individual cells.
Gross SM, Rotwein P.
J Cell Sci. 2015 Jun 3. pii: jcs.168773.
PubMed
Associated Plasmids |
| Lentiviral transduction of mammary epithelial cells. Iggo R, Richard E. Methods Mol Biol. 2015;1293:137-60. doi: 10.1007/978-1-4939-2519-3_8. PubMed |
| Spastin and ESCRT-III coordinate mitotic spindle disassembly and nuclear envelope sealing. Vietri M, Schink KO, Campsteijn C, Wegner CS, Schultz SW, Christ L, Thoresen SB, Brech A, Raiborg C, Stenmark H. Nature. 2015 Jun 11;522(7555):231-5. doi: 10.1038/nature14408. Epub 2015 Jun 3. PubMed |
| Reprogramming fibroblasts toward cardiomyocytes, neural stem cells and hepatocytes by cell activation and signaling-directed lineage conversion. Zhu S, Wang H, Ding S. Nat Protoc. 2015 Jul;10(7):959-73. doi: 10.1038/nprot.2015.059. Epub 2015 Jun 4. PubMed |
| Forward Programming of Cardiac Stem Cells by Homogeneous Transduction with MYOCD plus TBX5. Belian E, Noseda M, Abreu Paiva MS, Leja T, Sampson R, Schneider MD. PLoS One. 2015 Jun 5;10(6):e0125384. doi: 10.1371/journal.pone.0125384. eCollection 2015. PubMed |
| Evidence that synthetic lethality underlies the mutual exclusivity of oncogenic KRAS and EGFR mutations in lung adenocarcinoma. Unni AM, Lockwood WW, Zejnullahu K, Lee-Lin SQ, Varmus H. Elife. 2015 Jun 5;4:e06907. doi: 10.7554/eLife.06907. PubMed |
| Decoy receptors block TRAIL sensitivity at a supracellular level: the role of stromal cells in controlling tumour TRAIL sensitivity. O'Leary L, van der Sloot AM, Reis CR, Deegan S, Ryan AE, Dhami SP, Murillo LS, Cool RH, de Sampaio PC, Thompson K, Murphy G, Quax WJ, Serrano L, Samali A, Szegezdi E. Oncogene. 2015 Jun 8. doi: 10.1038/onc.2015.180. PubMed |
| Identification of bromodomain-containing protein-4 as a novel marker and epigenetic target in mast cell leukemia. Wedeh G, Cerny-Reiterer S, Eisenwort G, Herrmann H, Blatt K, Hadzijusufovic E, Sadovnik I, Mullauer L, Schwaab J, Hoffmann T, Bradner JE, Radia D, Sperr WR, Hoermann G, Reiter A, Horny HP, Zuber J, Arock M, Valent P. Leukemia. 2015 Jun 9. doi: 10.1038/leu.2015.138. PubMed |
| Tryptophan derivatives regulate the transcription of Oct4 in stem-like cancer cells. Cheng J, Li W, Kang B, Zhou Y, Song J, Dan S, Yang Y, Zhang X, Li J, Yin S, Cao H, Yao H, Zhu C, Yi W, Zhao Q, Xu X, Zheng M, Zheng S, Li L, Shen B, Wang YJ. Nat Commun. 2015 Jun 10;6:7209. doi: 10.1038/ncomms8209. PubMed |
| MYBL2 guides autophagy suppressor VDAC2 in the developing ovary to inhibit autophagy through a complex of VDAC2-BECN1-BCL2L1 in mammals. Yuan J, Zhang Y, Sheng Y, Fu X, Cheng H, Zhou R. Autophagy. 2015;11(7):1081-98. doi: 10.1080/15548627.2015.1040970. PubMed |
| Arylsulfatase A Overexpressing Human iPSC-derived Neural Cells Reduce CNS Sulfatide Storage in a Mouse Model of Metachromatic Leukodystrophy. Doerr J, Bockenhoff A, Ewald B, Ladewig J, Eckhardt M, Gieselmann V, Matzner U, Brustle O, Koch P. Mol Ther. 2015 Jun 10. doi: 10.1038/mt.2015.106. PubMed |
| Lysine-specific demethylase (LSD1/KDM1A) and MYCN cooperatively repress tumor suppressor genes in neuroblastoma. Amente S, Milazzo G, Sorrentino MC, Ambrosio S, Di Palo G, Lania L, Perini G, Majello B. Oncotarget. 2015 Jun 10;6(16):14572-83. PubMed |
| Transcriptional co-factor Transducin beta-like (TBL) 1 acts as a checkpoint in pancreatic cancer malignancy. Stoy C, Sundaram A, Rios Garcia M, Wang X, Seibert O, Zota A, Wendler S, Mannle D, Hinz U, Sticht C, Muciek M, Gretz N, Rose AJ, Greiner V, Hofmann TG, Bauer A, Hoheisel J, Berriel Diaz M, Gaida MM, Werner J, Schafmeier T, Strobel O, Herzig S. EMBO Mol Med. 2015 Jun 12;7(8):1048-62. doi: 10.15252/emmm.201404837. PubMed |
| Parkinson-causing alpha-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation. Dettmer U, Newman AJ, Soldner F, Luth ES, Kim NC, von Saucken VE, Sanderson JB, Jaenisch R, Bartels T, Selkoe D. Nat Commun. 2015 Jun 16;6:7314. doi: 10.1038/ncomms8314. PubMed |
| Lhx8 mediated Wnt and TGFbeta pathways in tooth development and regeneration. Zhou C, Yang G, Chen M, Wang C, He L, Xiang L, Chen D, Ling J, Mao JJ. Biomaterials. 2015 Sep;63:35-46. doi: 10.1016/j.biomaterials.2015.06.004. Epub 2015 Jun 3. PubMed |
| Binding of the sphingolipid S1P to hTERT stabilizes telomerase at the nuclear periphery by allosterically mimicking protein phosphorylation. Panneer Selvam S, De Palma RM, Oaks JJ, Oleinik N, Peterson YK, Stahelin RV, Skordalakes E, Ponnusamy S, Garrett-Mayer E, Smith CD, Ogretmen B. Sci Signal. 2015 Jun 16;8(381):ra58. doi: 10.1126/scisignal.aaa4998. PubMed |
| Pellino-1 positively regulates Toll-like Receptor (TLR) 2 and TLR4 signaling and is suppressed upon induction of endotoxin tolerance. Murphy M, Xiong Y, Pattabiraman G, Qiu F, Medvedev AE. J Biol Chem. 2015 Jun 16. pii: jbc.M115.640128. PubMed |
| The ORF61 protein encoded by Simian Varicella Virus and Varicella Zoster Virus inhibits NFkappaB signaling by interfering with IkappaBalpha degradation. Whitmer T, Malouli D, Uebelhoer LS, DeFilippis VR, Fruh K, Verweij MC. J Virol. 2015 Jun 17. pii: JVI.01149-15. PubMed |
| Induction of functional Brm protein from Brm knockout mice. Thompson KW, Marquez SB, Lu L, Reisman D. Oncoscience. 2015 Apr 18;2(4):349-61. eCollection 2015. PubMed |
| IGF1R/IRS1 signaling confers pathogenic activity on breast tumor cells lacking REST. Meyer K, Albaugh B, Schoenike B, Roopra A. Mol Cell Biol. 2015 Jun 22. pii: MCB.01149-14. PubMed |
| Expression of the multidrug transporter P-glycoprotein is inversely related to that of apoptosis-associated endogenous TRAIL. Souza PS, Madigan JP, Gillet JP, Kapoor K, Ambudkar SV, Maia RC, Gottesman MM, Leung Fung K. Exp Cell Res. 2015 Jun 19. pii: S0014-4827(15)30013-6. doi: 10.1016/j.yexcr.2015.06.005. PubMed |
| CRISPR-mediated genotypic and phenotypic correction of a chronic granulomatous disease mutation in human iPS cells. Flynn R, Grundmann A, Renz P, Hanseler W, James WS, Cowley SA, Moore MD. Exp Hematol. 2015 Oct;43(10):838-848.e3. doi: 10.1016/j.exphem.2015.06.002. Epub 2015 Jun 19. PubMed |
| Lack of Rybp in Mouse Embryonic Stem Cells Impairs Cardiac Differentiation. Ujhelly O, Szabo V, Kovacs G, Vajda F, Mallok S, Prorok J, Acsai K, Hegedus Z, Krebs S, Dinnyes A, Pirity MK. Stem Cells Dev. 2015 Jun 25. PubMed |
| mPGES-1 in prostate cancer controls stemness and amplifies EGFR-driven oncogenicity. Finetti F, Terzuoli E, Giachetti A, Santi R, Villari D, Hanaka H, Radmark O, Ziche M, Donnini S. Endocr Relat Cancer. 2015 Jun 25. pii: ERC-15-0277. PubMed |
| Early growth response gene (EGR)-1 regulates leukotriene D4-induced cytokine transcription in Hodgkin lymphoma cells. Han H, Xue-Franzen Y, Miao X, Nagy E, Li N, Xu D, Sjoberg J, Bjorkholm M, Claesson HE. Prostaglandins Other Lipid Mediat. 2015 Jun 23. pii: S1098-8823(15)00075-1. doi: 10.1016/j.prostaglandins.2015.06.004. PubMed |
| DEAD-box RNA helicase DDX23 modulates glioma malignancy via elevating miR-21 biogenesis. Yin J, Park G, Lee JE, Choi EY, Park JY, Kim TH, Park N, Jin X, Jung JE, Shin D, Hong JH, Kim H, Yoo H, Lee SH, Kim YJ, Park JB, Kim JH. Brain. 2015 Sep;138(Pt 9):2553-70. doi: 10.1093/brain/awv167. Epub 2015 Jun 29. PubMed |
| MicroRNA-665 Regulates Dentinogenesis through MicroRNA-Mediated Silencing and Epigenetic Mechanisms. Heair HM, Kemper AG, Roy B, Lopes HB, Rashid H, Clarke JC, Afreen LK, Ferraz E, Kim E, Javed A, Beloti M, MacDougall M, Hassan M. Mol Cell Biol. 2015 Jun 29. pii: MCB.00093-15. PubMed |
| Gene Silencing by RNAi in Mammalian Cells. Ponthan F, Yusoff NM, Soria NM, Heidenreich O, Coffey K. Curr Protoc Mol Biol. 2015 Jul 1;111:26.2.1-26.2.17. doi: 10.1002/0471142727.mb2602s111. PubMed |
| Increased titer and reduced lactate accumulation in recombinant retrovirus production through the down-regulation of HIF1 and PDK. Rodrigues AF, Guerreiro MR, Formas-Oliveira AS, Fernandes P, Blechert AK, Genzel Y, Alves PM, Hu WS, Coroadinha AS. Biotechnol Bioeng. 2015 Jul 1. doi: 10.1002/bit.25691. PubMed |
| ATP binding by NLRP7 is required for inflammasome activation in response to bacterial lipopeptides. Radian AD, Khare S, Chu LH, Dorfleutner A, Stehlik C. Mol Immunol. 2015 Jul 1. pii: S0161-5890(15)00437-X. doi: 10.1016/j.molimm.2015.06.013. PubMed |
NKX2-5 mutations causative for congenital heart disease retain functionality and are directed to hundreds of targets.
Bouveret R, Waardenberg AJ, Schonrock N, Ramialison M, Doan T, de Jong D, Bondue A, Kaur G, Mohamed S, Fonoudi H, Chen CM, Wouters MA, Bhattacharya S, Plachta N, Dunwoodie SL, Chapman G, Blanpain C, Harvey RP.
Elife. 2015 Jul 6;4. doi: 10.7554/eLife.06942.
PubMed
Associated Plasmids |
| LMAN1 (ERGIC-53) is a potential carrier protein for matrix metalloproteinase-9 glycoprotein secretion. Duellman T, Burnett J, Shin A, Yang J. Biochem Biophys Res Commun. 2015 Jul 3. pii: S0006-291X(15)30222-9. doi: 10.1016/j.bbrc.2015.06.164. PubMed |
| Myogenic induction of adult and pluripotent stem cells using recombinant proteins. Perini I, Elia I, Lo Nigro A, Ronzoni F, Berardi E, Grosemans H, Fukada S, Sampaolesi M. Biochem Biophys Res Commun. 2015 Aug 28;464(3):755-61. doi: 10.1016/j.bbrc.2015.07.022. Epub 2015 Jul 8. PubMed |
| Use of Ferritin Expression, Regulated by Neural Cell-Specific Promoters in Human Adipose Tissue-Derived Mesenchymal Stem Cells, to Monitor Differentiation with Magnetic Resonance Imaging In Vitro. Song C, Wang J, Mo C, Mu S, Jiang X, Li X, Zhong S, Zhao Z, Zhou G. PLoS One. 2015 Jul 15;10(7):e0132480. doi: 10.1371/journal.pone.0132480. eCollection 2015. PubMed |
| Exosome-mediated microRNA signaling from breast cancer cells is altered by the anti-angiogenesis agent docosahexaenoic acid (DHA). Hannafon BN, Carpenter KJ, Berry WL, Janknecht R, Dooley WC, Ding WQ. Mol Cancer. 2015 Jul 16;14:133. doi: 10.1186/s12943-015-0400-7. PubMed |
| Mutant p53-R273H mediates cancer cell survival and anoikis resistance through AKT-dependent suppression of BCL2-modifying factor (BMF). Tan BS, Tiong KH, Choo HL, Chung FF, Hii LW, Tan SH, Yap IK, Pani S, Khor NT, Wong SF, Rosli R, Cheong SK, Leong CO. Cell Death Dis. 2015 Jul 16;6:e1826. doi: 10.1038/cddis.2015.191. PubMed |
| Expression of an estrogen-regulated variant transcript of the peroxisomal branched chain fatty acid oxidase ACOX2 in breast carcinomas. Bjorklund SS, Kristensen VN, Seiler M, Kumar S, Alnaes GI, Ming Y, Kerrigan J, Naume B, Sachidanandam R, Bhanot G, Borresen-Dale AL, Ganesan S. BMC Cancer. 2015 Jul 17;15:524. doi: 10.1186/s12885-015-1510-8. PubMed |
| Overexpression of the MRI Reporter Genes Ferritin and Transferrin Receptor Affect Iron Homeostasis and Produce Limited Contrast in Mesenchymal Stem Cells. Pereira SM, Moss D, Williams SR, Murray P, Taylor A. Int J Mol Sci. 2015 Jul 8;16(7):15481-96. doi: 10.3390/ijms160715481. PubMed |
| A Genome-wide CRISPR Screen in Primary Immune Cells to Dissect Regulatory Networks. Parnas O, Jovanovic M, Eisenhaure TM, Herbst RH, Dixit A, Ye CJ, Przybylski D, Platt RJ, Tirosh I, Sanjana NE, Shalem O, Satija R, Raychowdhury R, Mertins P, Carr SA, Zhang F, Hacohen N, Regev A. Cell. 2015 Jul 30;162(3):675-86. doi: 10.1016/j.cell.2015.06.059. Epub 2015 Jul 16. PubMed |
| Spontaneous Cell Competition in Immortalized Mammalian Cell Lines. Penzo-Mendez AI, Chen YJ, Li J, Witze ES, Stanger BZ. PLoS One. 2015 Jul 22;10(7):e0132437. doi: 10.1371/journal.pone.0132437. eCollection 2015. PubMed |
| Polarity Protein Scrib Facilitates Endothelial Inflammatory Signaling. Kruse C, Kurz AR, Palfi K, Humbert PO, Sperandio M, Brandes RP, Fork C, Michaelis UR. Arterioscler Thromb Vasc Biol. 2015 Sep;35(9):1954-62. doi: 10.1161/ATVBAHA.115.305678. Epub 2015 Jul 23. PubMed |
| RhoB upregulation leads to either apoptosis or cytostasis through differential target selection. Marlow LA, Bok I, Smallridge RC, Copland JA. Endocr Relat Cancer. 2015 Oct;22(5):777-92. doi: 10.1530/ERC-14-0302. Epub 2015 Jul 23. PubMed |
| The role of frataxin in doxorubicin-mediated cardiac hypertrophy. Mouli S, Nanayakkara G, AlAlasmari A, Eldoumani H, Fu X, Berlin A, Lohani M, Nie B, Arnold RD, Kavazis A, Smith F, Beyers R, Denney T, Dhanasekaran M, Zhong J, Quindry J, Amin R. Am J Physiol Heart Circ Physiol. 2015 Sep;309(5):H844-59. doi: 10.1152/ajpheart.00182.2015. Epub 2015 Jul 24. PubMed |
Adhesion to fibronectin regulates Hippo signaling via the FAK-Src-PI3K pathway.
Kim NG, Gumbiner BM.
J Cell Biol. 2015 Aug 3;210(3):503-15. doi: 10.1083/jcb.201501025. Epub 2015 Jul 27.
PubMed
Associated Plasmids |
| alpha-5 Laminin Synthesized by Human Pluripotent Stem Cells Promotes Self-Renewal. Laperle A, Hsiao C, Lampe M, Mortier J, Saha K, Palecek SP, Masters KS. Stem Cell Reports. 2015 Aug 11;5(2):195-206. doi: 10.1016/j.stemcr.2015.06.009. Epub 2015 Jul 30. PubMed |
| Scalable Electrophysiological Investigation of iPS Cell-Derived Cardiomyocytes Obtained by a Lentiviral Purification Strategy. Friedrichs S, Malan D, Voss Y, Sasse P. J Clin Med. 2015 Jan 8;4(1):102-23. doi: 10.3390/jcm4010102. PubMed |
Genetic determinants of FOXM1 overexpression in epithelial ovarian cancer and functional contribution to cell cycle progression.
Barger CJ, Zhang W, Hillman J, Stablewski AB, Higgins MJ, Vanderhyden BC, Odunsi K, Karpf AR.
Oncotarget. 2015 Jul 16.
PubMed
Associated Plasmids |
| The Mutant KRAS Gene Up-regulates BCL-XL Protein via STAT3 to Confer Apoptosis Resistance That Is Reversed by BIM Protein Induction and BCL-XL Antagonism. Zaanan A, Okamoto K, Kawakami H, Khazaie K, Huang S, Sinicrope FA. J Biol Chem. 2015 Sep 25;290(39):23838-49. doi: 10.1074/jbc.M115.657833. Epub 2015 Aug 5. PubMed |
| Separating myoblast differentiation from muscle cell fusion using IGF-I and the p38 MAP kinase inhibitor SB202190. Gardner S, Gross SM, David LL, Klimek JE, Rotwein P. Am J Physiol Cell Physiol. 2015 Oct 1;309(7):C491-500. doi: 10.1152/ajpcell.00184.2015. Epub 2015 Aug 5. PubMed |
| Nutlin-3 sensitizes nasopharyngeal carcinoma cells to cisplatin-induced cytotoxicity. Voon YL, Ahmad M, Wong PF, Husaini R, Ng WT, Leong CO, Lane DP, Khoo AS. Oncol Rep. 2015 Oct;34(4):1692-700. doi: 10.3892/or.2015.4177. Epub 2015 Aug 5. PubMed |
| CFTR inactivation by lentiviral vector-mediated RNA interference and CRISPR-Cas9 genome editing in human airway epithelial cells. Bellec J, Bacchetta M, Losa D, Anegon I, Chanson M, Nguyen TH. Curr Gene Ther. 2015;15(5):447-59. PubMed |
| Atypical protein kinase C induces cell transformation by disrupting Hippo/Yap signaling. Archibald A, Al-Masri M, Liew-Spilger A, McCaffrey L. Mol Biol Cell. 2015 Oct 15;26(20):3578-95. doi: 10.1091/mbc.E15-05-0265. Epub 2015 Aug 12. PubMed |
| Mucosally transplanted mesenchymal stem cells stimulate intestinal healing by promoting angiogenesis. Manieri NA, Mack MR, Himmelrich MD, Worthley DL, Hanson EM, Eckmann L, Wang TC, Stappenbeck TS. J Clin Invest. 2015 Sep;125(9):3606-18. doi: 10.1172/JCI81423. Epub 2015 Aug 17. PubMed |
| Antisense-miR-21 enhances differentiation/apoptosis and reduces cancer stemness state on anaplastic thyroid cancer. Haghpanah V, Fallah P, Tavakoli R, Naderi M, Samimi H, Soleimani M, Larijani B. Tumour Biol. 2015 Aug 20. PubMed |
| Optimization of a multiplex CRISPR/Cas system for use as an antiviral therapeutic. Kennedy EM, Kornepati AV, Mefferd AL, Marshall JB, Tsai K, Bogerd HP, Cullen BR. Methods. 2015 Dec;91:82-6. doi: 10.1016/j.ymeth.2015.08.012. Epub 2015 Aug 17. PubMed |
| Retroviral Transduction of T Cells and T Cell Precursors. Simmons A, Alberola-Ila J. Methods Mol Biol. 2016;1323:99-108. doi: 10.1007/978-1-4939-2809-5_8. PubMed |
| Nuclear Localization of DNAJB6 Is Associated With Survival of Patients With Esophageal Cancer and Reduces AKT Signaling and Proliferation of Cancer Cells. Yu VZ, Wong VC, Dai W, Ko JM, Lam AK, Chan KW, Samant RS, Lung HL, Shuen WH, Law S, Chan YP, Lee NP, Tong DK, Law TT, Lee VH, Lung ML. Gastroenterology. 2015 Dec;149(7):1825-1836.e5. doi: 10.1053/j.gastro.2015.08.025. Epub 2015 Aug 22. PubMed |
| JAM-A regulates cortical dynein localization through Cdc42 to control planar spindle orientation during mitosis. Tuncay H, Brinkmann BF, Steinbacher T, Schurmann A, Gerke V, Iden S, Ebnet K. Nat Commun. 2015 Aug 26;6:8128. doi: 10.1038/ncomms9128. PubMed |
| CD45+ Cells Present Within Mesenchymal Stem Cell Populations Affect Network Formation of Blood-Derived Endothelial Outgrowth Cells. Peters EB, Christoforou N, Moore E, West JL, Truskey GA. Biores Open Access. 2015 Jan 1;4(1):75-88. doi: 10.1089/biores.2014.0029. eCollection 2015. PubMed |
| Pellino-3 promotes endotoxin tolerance and acts as a negative regulator of TLR2 and TLR4 signaling. Murphy MB, Xiong Y, Pattabiraman G, Manavalan TT, Qiu F, Medvedev AE. J Leukoc Biol. 2015 Dec;98(6):963-74. doi: 10.1189/jlb.2VMA0515-229RR. Epub 2015 Aug 26. PubMed |
| Predicting the molecular role of MEIS1 in esophageal squamous cell carcinoma. Rad A, Farshchian M, Forghanifard MM, Matin MM, Bahrami AR, Geerts D, A'rabi A, Memar B, Abbaszadegan MR. Tumour Biol. 2015 Aug 28. PubMed |
| Mutation of the BRCA1 SQ-cluster results in aberrant mitosis, reduced homologous recombination, and a compensatory increase in non-homologous end joining. Beckta JM, Dever SM, Gnawali N, Khalil A, Sule A, Golding SE, Rosenberg E, Narayanan A, Kehn-Hall K, Xu B, Povirk LF, Valerie K. Oncotarget. 2015 Sep 29;6(29):27674-87. doi: 10.18632/oncotarget.4876. PubMed |
| p53-regulated autophagy is controlled by glycolysis and determines cell fate. Duan L, Perez RE, Davaadelger B, Dedkova EN, Blatter LA, Maki CG. Oncotarget. 2015 Sep 15;6(27):23135-56. PubMed |
| Release of Vesicular Stomatitis Virus Spike Protein G-Pseudotyped Lentivirus from the Host Cell Is Impaired upon Low-Density Lipoprotein Receptor Overexpression. Otahal A, Fuchs R, Al-Allaf FA, Blaas D. J Virol. 2015 Nov;89(22):11723-6. doi: 10.1128/JVI.01869-15. Epub 2015 Sep 2. PubMed |
| Transcriptome Profiling Reveals Degree of Variability in Induced Pluripotent Stem Cell Lines: Impact for Human Disease Modeling. Schuster J, Halvardson J, Pilar Lorenzo L, Ameur A, Sobol M, Raykova D, Anneren G, Feuk L, Dahl N. Cell Reprogram. 2015 Oct;17(5):327-37. doi: 10.1089/cell.2015.0009. Epub 2015 Sep 8. PubMed |
| The Interferon-induced Transmembrane Proteins, IFITM1, IFITM2, and IFITM3 Inhibit Hepatitis C Virus Entry. Narayana SK, Helbig KJ, McCartney EM, Eyre NS, Bull RA, Eltahla A, Lloyd AR, Beard MR. J Biol Chem. 2015 Oct 23;290(43):25946-59. doi: 10.1074/jbc.M115.657346. Epub 2015 Sep 9. PubMed |
| Structural centrosome aberrations favor proliferation by abrogating microtubule-dependent tissue integrity of breast epithelial mammospheres. Schnerch D, Nigg EA. Oncogene. 2015 Sep 14. doi: 10.1038/onc.2015.332. PubMed |
| miR-128 represses L1 retrotransposition by binding directly to L1 RNA. Hamdorf M, Idica A, Zisoulis DG, Gamelin L, Martin C, Sanders KJ, Pedersen IM. Nat Struct Mol Biol. 2015 Oct;22(10):824-31. doi: 10.1038/nsmb.3090. Epub 2015 Sep 14. PubMed |
| The TRAF-interacting protein (TRAIP) is a novel E2F target with peak expression in mitosis. Chapard C, Hohl D, Huber M. Oncotarget. 2015 Aug 28;6(25):20933-45. PubMed |
| Global Transcriptome Analysis Reveals That Poly(ADP-Ribose) Polymerase 1 Regulates Gene Expression through EZH2. Martin KA, Cesaroni M, Denny MF, Lupey LN, Tempera I. Mol Cell Biol. 2015 Dec;35(23):3934-44. doi: 10.1128/MCB.00635-15. Epub 2015 Sep 14. PubMed |
MicroRNA-based conversion of human fibroblasts into striatal medium spiny neurons.
Richner M, Victor MB, Liu Y, Abernathy D, Yoo AS.
Nat Protoc. 2015 Oct;10(10):1543-55. doi: 10.1038/nprot.2015.102. Epub 2015 Sep 17.
PubMed
Associated Plasmids |
| Basal cells of the human airways acquire mesenchymal traits in idiopathic pulmonary fibrosis and in culture. Jonsdottir HR, Arason AJ, Palsson R, Franzdottir SR, Gudbjartsson T, Isaksson HJ, Gudmundsson G, Gudjonsson T, Magnusson MK. Lab Invest. 2015 Dec;95(12):1418-28. doi: 10.1038/labinvest.2015.114. Epub 2015 Sep 21. PubMed |
| Exogenous marker-engineered mesenchymal stem cells detect cancer and metastases in a simple blood assay. Liu L, Zhang SX, Aeran R, Liao W, Lu M, Polovin G, Pone EJ, Zhao W. Stem Cell Res Ther. 2015 Sep 21;6:181. doi: 10.1186/s13287-015-0151-9. PubMed |
| Routes of Ca2+ Shuttling during Ca2+ Oscillations: FOCUS ON THE ROLE OF MITOCHONDRIAL Ca2+ HANDLING AND CYTOSOLIC Ca2+ BUFFERS. Pecze L, Blum W, Schwaller B. J Biol Chem. 2015 Nov 20;290(47):28214-30. doi: 10.1074/jbc.M115.663179. Epub 2015 Sep 22. PubMed |
| OTX2 is a therapeutic target for retinoblastoma and may function as a common factor between C-MYC, CRX, and phosphorylated RB pathways. Li J, Di C, Jing J, Di Q, Nakhla J, Adamson DC. Int J Oncol. 2015 Nov;47(5):1703-10. doi: 10.3892/ijo.2015.3179. Epub 2015 Sep 23. PubMed |
Direct Induction of Trophoblast Stem Cells from Murine Fibroblasts.
Kubaczka C, Senner CE, Cierlitza M, Arauzo-Bravo MJ, Kuckenberg P, Peitz M, Hemberger M, Schorle H.
Cell Stem Cell. 2015 Sep 22. pii: S1934-5909(15)00360-4. doi: 10.1016/j.stem.2015.08.005.
PubMed
Associated Plasmids |
| LKB1 loss promotes endometrial cancer progression via CCL2-dependent macrophage recruitment. Pena CG, Nakada Y, Saatcioglu HD, Aloisio GM, Cuevas I, Zhang S, Miller DS, Lea JS, Wong KK, DeBerardinis RJ, Amelio AL, Brekken RA, Castrillon DH. J Clin Invest. 2015 Nov 2;125(11):4063-76. doi: 10.1172/JCI82152. Epub 2015 Sep 28. PubMed |
| EMMPRIN regulates tumor growth and metastasis by recruiting bone marrow-derived cells through paracrine signaling of SDF-1 and VEGF. Chen Y, Gou X, Kong DK, Wang X, Wang J, Chen Z, Huang C, Zhou J. Oncotarget. 2015 Oct 20;6(32):32575-85. doi: 10.18632/oncotarget.5331. PubMed |
| Competitive Inhibition of the Endoplasmic Reticulum Signal Peptidase by Non-cleavable Mutant Preprotein Cargos. Cui J, Chen W, Sun J, Guo H, Madley R, Xiong Y, Pan X, Wang H, Tai AW, Weiss MA, Arvan P, Liu M. J Biol Chem. 2015 Nov 20;290(47):28131-40. doi: 10.1074/jbc.M115.692350. Epub 2015 Oct 7. PubMed |
| Succination is Increased on Select Proteins in the Brainstem of the NADH dehydrogenase (ubiquinone) Fe-S protein 4 (Ndufs4) Knockout Mouse, a Model of Leigh Syndrome. Piroli GG, Manuel AM, Clapper AC, Walla MD, Baatz JE, Palmiter RD, Quintana A, Frizzell N. Mol Cell Proteomics. 2016 Feb;15(2):445-61. doi: 10.1074/mcp.M115.051516. Epub 2015 Oct 8. PubMed |
| The role of APC/C in replication stress and origin of genomic instability. Greil C, Krohs J, Schnerch D, Follo M, Felthaus J, Engelhardt M, Wasch R. Oncogene. 2015 Oct 12. doi: 10.1038/onc.2015.367. PubMed |
| MFG-E8 Is Critical for Embryonic Stem Cell-Mediated T Cell Immunomodulation. Tan Y, AlKhamees B, Jia D, Li L, Couture JF, Figeys D, Jinushi M, Wang L. Stem Cell Reports. 2015 Nov 10;5(5):741-52. doi: 10.1016/j.stemcr.2015.09.005. Epub 2015 Oct 8. PubMed |
| Transcriptional repression by the HDAC4-RelB-p52 complex regulates multiple myeloma survival and growth. Vallabhapurapu SD, Noothi SK, Pullum DA, Lawrie CH, Pallapati R, Potluri V, Kuntzen C, Khan S, Plas DR, Orlowski RZ, Chesi M, Kuehl WM, Bergsagel PL, Karin M, Vallabhapurapu S. Nat Commun. 2015 Oct 12;6:8428. doi: 10.1038/ncomms9428. PubMed |
| Reliable and inexpensive expression of large, tagged, exogenous proteins in murine bone marrow-derived macrophages using a second generation lentiviral system. Miller MR, Blystone SD. J Biol Methods. 2015;2(3):e23. PubMed |
| Targeting of BCL2 Family Proteins with ABT-199 and Homoharringtonine Reveals BCL2- and MCL1-Dependent Subgroups of Diffuse Large B-Cell Lymphoma. Klanova M, Andera L, Brazina J, Svadlenka J, Benesova S, Soukup J, Prukova D, Vejmelkova D, Jaksa R, Helman K, Vockova P, Lateckova L, Molinsky J, Maswabi BC, Alam M, Kodet R, Pytlik R, Trneny M, Klener P. Clin Cancer Res. 2015 Oct 14. PubMed |
| Knockdown of GLP-1 Receptors in Vagal Afferents Affects Normal Food Intake and Glycemia. Krieger JP, Arnold M, Pettersen KG, Lossel P, Langhans W, Lee SJ. Diabetes. 2016 Jan;65(1):34-43. doi: 10.2337/db15-0973. Epub 2015 Oct 15. PubMed |
| Targeting mitochondrial RNA polymerase in acute myeloid leukemia. Bralha FN, Liyanage SU, Hurren R, Wang X, Son MH, Fung TA, Chingcuanco FB, Tung AY, Andreazza AC, Psarianos P, Schimmer AD, Salmena L, Laposa RR. Oncotarget. 2015 Nov 10;6(35):37216-28. doi: 10.18632/oncotarget.6129. PubMed |
| Interferon Kappa Inhibits Human Papillomavirus 31 Transcription by Inducing Sp100 Proteins. Habiger C, Jager G, Walter M, Iftner T, Stubenrauch F. J Virol. 2015 Oct 21;90(2):694-704. doi: 10.1128/JVI.02137-15. PubMed |
| TrkA is amplified in malignant melanoma patients and induces an anti-proliferative response in cell lines. Pasini L, Re A, Tebaldi T, Ricci G, Boi S, Adami V, Barbareschi M, Quattrone A. BMC Cancer. 2015 Oct 24;15:777. doi: 10.1186/s12885-015-1791-y. PubMed |
Highly specific epigenome editing by CRISPR-Cas9 repressors for silencing of distal regulatory elements.
Thakore PI, D'Ippolito AM, Song L, Safi A, Shivakumar NK, Kabadi AM, Reddy TE, Crawford GE, Gersbach CA.
Nat Methods. 2015 Dec;12(12):1143-9. doi: 10.1038/nmeth.3630. Epub 2015 Oct 26.
PubMed
Associated Plasmids |
| Skeletal Muscle Phospholipid Metabolism Regulates Insulin Sensitivity and Contractile Function. Funai K, Lodhi IJ, Spears LD, Yin L, Song H, Klein S, Semenkovich CF. Diabetes. 2016 Feb;65(2):358-70. doi: 10.2337/db15-0659. Epub 2015 Oct 28. PubMed |
| Identification of short-form RON as a novel intrinsic resistance mechanism for anti-MET therapy in MET-positive gastric cancer. Wu Z, Zhang Z, Ge X, Lin Y, Dai C, Chang J, Liu X, Geng R, Wang C, Chen H, Sun M, Guo W, Li J. Oncotarget. 2015 Dec 1;6(38):40519-34. doi: 10.18632/oncotarget.5816. PubMed |
| Combinatorial BTK and MALT1 inhibition augments killing of CD79 mutant diffuse large B cell lymphoma. Nagel D, Bognar M, Eitelhuber AC, Kutzner K, Vincendeau M, Krappmann D. Oncotarget. 2015 Dec 8;6(39):42232-42. doi: 10.18632/oncotarget.6273. PubMed |
| Differentiation of human ESCs to retinal ganglion cells using a CRISPR engineered reporter cell line. Sluch VM, Davis CH, Ranganathan V, Kerr JM, Krick K, Martin R, Berlinicke CA, Marsh-Armstrong N, Diamond JS, Mao HQ, Zack DJ. Sci Rep. 2015 Nov 13;5:16595. doi: 10.1038/srep16595. PubMed |
| The leukodystrophy protein FAM126A (hyccin) regulates PtdIns(4)P synthesis at the plasma membrane. Baskin JM, Wu X, Christiano R, Oh MS, Schauder CM, Gazzerro E, Messa M, Baldassari S, Assereto S, Biancheri R, Zara F, Minetti C, Raimondi A, Simons M, Walther TC, Reinisch KM, De Camilli P. Nat Cell Biol. 2016 Jan;18(1):132-8. doi: 10.1038/ncb3271. Epub 2015 Nov 16. PubMed |
| Fat4 suppression induces Yap translocation accounting for the promoted proliferation and migration of gastric cancer cells. Ma L, Cui J, Xi H, Bian S, Wei B, Chen L. Cancer Biol Ther. 2016;17(1):36-47. doi: 10.1080/15384047.2015.1108488. PubMed |
| ETS family transcriptional regulators drive chromatin dynamics and malignancy in squamous cell carcinomas. Yang H, Schramek D, Adam RC, Keyes BE, Wang P, Zheng D, Fuchs E. Elife. 2015 Nov 21;4. pii: e10870. doi: 10.7554/eLife.10870. PubMed |
| Targeting p300 Addiction in CBP-Deficient Cancers Causes Synthetic Lethality by Apoptotic Cell Death due to Abrogation of MYC Expression. Ogiwara H, Sasaki M, Mitachi T, Oike T, Higuchi S, Tominaga Y, Kohno T. Cancer Discov. 2016 Apr;6(4):430-45. doi: 10.1158/2159-8290.CD-15-0754. Epub 2015 Nov 24. PubMed |
| Non-epigenetic function of HDAC8 in regulating breast cancer stem cells by maintaining Notch1 protein stability. Chao MW, Chu PC, Chuang HC, Shen FH, Chou CC, Hsu EC, Himmel LE, Huang HL, Tu HJ, Kulp SK, Teng CM, Chen CS. Oncotarget. 2016 Jan 12;7(2):1796-807. doi: 10.18632/oncotarget.6427. PubMed |
| PTEN deficiency reprogrammes human neural stem cells towards a glioblastoma stem cell-like phenotype. Duan S, Yuan G, Liu X, Ren R, Li J, Zhang W, Wu J, Xu X, Fu L, Li Y, Yang J, Zhang W, Bai R, Yi F, Suzuki K, Gao H, Esteban CR, Zhang C, Izpisua Belmonte JC, Chen Z, Wang X, Jiang T, Qu J, Tang F, Liu GH. Nat Commun. 2015 Dec 3;6:10068. doi: 10.1038/ncomms10068. PubMed |
| alpha-synuclein interacts with SOD1 and promotes its oligomerization. Helferich AM, Ruf WP, Grozdanov V, Freischmidt A, Feiler MS, Zondler L, Ludolph AC, McLean PJ, Weishaupt JH, Danzer KM. Mol Neurodegener. 2015 Dec 8;10:66. doi: 10.1186/s13024-015-0062-3. PubMed |
| The Notch and Wnt pathways regulate stemness and differentiation in human fallopian tube organoids. Kessler M, Hoffmann K, Brinkmann V, Thieck O, Jackisch S, Toelle B, Berger H, Mollenkopf HJ, Mangler M, Sehouli J, Fotopoulou C, Meyer TF. Nat Commun. 2015 Dec 8;6:8989. doi: 10.1038/ncomms9989. PubMed |
| Deregulated KLF4 Expression in Myeloid Leukemias Alters Cell Proliferation and Differentiation through MicroRNA and Gene Targets. Morris VA, Cummings CL, Korb B, Boaglio S, Oehler VG. Mol Cell Biol. 2015 Dec 7;36(4):559-73. doi: 10.1128/MCB.00712-15. PubMed |
| A Common CCK-B Receptor Intronic Variant in Pancreatic Adenocarcinoma in a Hungarian Cohort. Balazs A, Nemeth BC, Ordog B, Hegyi E, Hritz I, Czako L, Czimmer J, Godi S, Csiszko A, Rakonczay Z Jr, Parniczky A, Izbeki F, Halasz A, Kahan Z, Hegyi P, Sahin-Toth M. Pancreas. 2016 Apr;45(4):541-5. doi: 10.1097/MPA.0000000000000539. PubMed |
| Characterization of a Novel Human-Specific STING Agonist that Elicits Antiviral Activity Against Emerging Alphaviruses. Sali TM, Pryke KM, Abraham J, Liu A, Archer I, Broeckel R, Staverosky JA, Smith JL, Al-Shammari A, Amsler L, Sheridan K, Nilsen A, Streblow DN, DeFilippis VR. PLoS Pathog. 2015 Dec 8;11(12):e1005324. doi: 10.1371/journal.ppat.1005324. eCollection 2015 Dec. PubMed |
| Transduction of an immortalized olfactory ensheathing glia cell line with the green fluorescent protein (GFP) gene: Evaluation of its neuroregenerative capacity as a proof of concept. Plaza N, Simon D, Sierra J, Moreno-Flores MT. Neurosci Lett. 2016 Jan 26;612:25-31. doi: 10.1016/j.neulet.2015.12.001. Epub 2015 Dec 3. PubMed |
| C/EBPgamma is a critical regulator of cellular stress response networks through heterodimerization with ATF4. Huggins CJ, Mayekar MK, Martin N, Saylor KL, Gonit M, Jailwala P, Kasoji M, Haines DC, Quinones OA, Johnson PF. Mol Cell Biol. 2015 Dec 14. pii: MCB.00911-15. PubMed |
| A Gene Expression Signature Associated with Overall Survival in Patients with Hepatocellular Carcinoma Suggests a New Treatment Strategy. Gillet JP, Andersen JB, Madigan JP, Varma S, Bagni RK, Powell K, Burgan WE, Wu CP, Calcagno AM, Ambudkar SV, Thorgeirsson SS, Gottesman MM. Mol Pharmacol. 2016 Feb;89(2):263-72. doi: 10.1124/mol.115.101360. Epub 2015 Dec 14. PubMed |
| Specific induction of endogenous viral restriction factors using CRISPR/Cas-derived transcriptional activators. Bogerd HP, Kornepati AV, Marshall JB, Kennedy EM, Cullen BR. Proc Natl Acad Sci U S A. 2015 Dec 29;112(52):E7249-56. doi: 10.1073/pnas.1516305112. Epub 2015 Dec 14. PubMed |
| TBX3 Knockdown Decreases Reprogramming Efficiency of Human Cells. Klingenstein M, Raab S, Achberger K, Kleger A, Liebau S, Linta L. Stem Cells Int. 2016;2016:6759343. doi: 10.1155/2016/6759343. Epub 2015 Nov 30. PubMed |
| Upregulation of EMMPRIN (OX47) in Rat Dorsal Root Ganglion Contributes to the Development of Mechanical Allodynia after Nerve Injury. Wang Q, Sun Y, Ren Y, Gao Y, Tian L, Liu Y, Pu Y, Gou X, Chen Y, Lu Y. Neural Plast. 2015;2015:249756. doi: 10.1155/2015/249756. Epub 2015 Nov 30. PubMed |
| Manipulation of the N-terminal sequence of the Borna disease virus X protein improves its mitochondrial targeting and neuroprotective potential. Ferre CA, Davezac N, Thouard A, Peyrin JM, Belenguer P, Miquel MC, Gonzalez-Dunia D, Szelechowski M. FASEB J. 2015 Dec 23. pii: fj.15-279620. PubMed |
| Genome-Wide Transcriptional Regulation Mediated by Biochemically Distinct SWI/SNF Complexes. Raab JR, Resnick S, Magnuson T. PLoS Genet. 2015 Dec 30;11(12):e1005748. doi: 10.1371/journal.pgen.1005748. eCollection 2015 Dec. PubMed |
| PARK2 enhancement is able to compensate mitophagy alterations found in sporadic Alzheimer's disease. Martin-Maestro P, Gargini R, Perry G, Avila J, Garcia-Escudero V. Hum Mol Genet. 2016 Feb 15;25(4):792-806. doi: 10.1093/hmg/ddv616. Epub 2015 Dec 31. PubMed |
| The Polymerase Activity of Mammalian DNA Pol zeta Is Specifically Required for Cell and Embryonic Viability. Lange SS, Tomida J, Boulware KS, Bhetawal S, Wood RD. PLoS Genet. 2016 Jan 4;12(1):e1005759. doi: 10.1371/journal.pgen.1005759. eCollection 2016 Jan. PubMed |
| CRISPR Technology for Genome Activation and Repression in Mammalian Cells. Du D, Qi LS. Cold Spring Harb Protoc. 2016 Jan 4;2016(1):pdb.prot090175. doi: 10.1101/pdb.prot090175. PubMed |
| A Conserved Interaction between a C-Terminal Motif in Norovirus VPg and the HEAT-1 Domain of eIF4G Is Essential for Translation Initiation. Leen EN, Sorgeloos F, Correia S, Chaudhry Y, Cannac F, Pastore C, Xu Y, Graham SC, Matthews SJ, Goodfellow IG, Curry S. PLoS Pathog. 2016 Jan 6;12(1):e1005379. doi: 10.1371/journal.ppat.1005379. eCollection 2016 Jan. PubMed |
| Inhibition of Canonical NF-kappaB Signaling by a Small Molecule Targeting NEMO-Ubiquitin Interaction. Vincendeau M, Hadian K, Messias AC, Brenke JK, Halander J, Griesbach R, Greczmiel U, Bertossi A, Stehle R, Nagel D, Demski K, Velvarska H, Niessing D, Geerlof A, Sattler M, Krappmann D. Sci Rep. 2016 Jan 7;6:18934. doi: 10.1038/srep18934. PubMed |
| Epithelial but not stromal expression of collagen alpha-1(III) is a diagnostic and prognostic indicator of colorectal carcinoma. Wang XQ, Tang ZX, Yu D, Cui SJ, Jiang YH, Zhang Q, Wang J, Yang PY, Liu F. Oncotarget. 2016 Feb 23;7(8):8823-38. doi: 10.18632/oncotarget.6815. PubMed |
| Research Resource: Genetic Labeling of Human Islet Alpha Cells. Pauerstein PT, Park KM, Peiris HS, Wang J, Kim SK. Mol Endocrinol. 2016 Feb;30(2):248-53. doi: 10.1210/me.2015-1220. Epub 2016 Jan 8. PubMed |
| C9orf72 promoter hypermethylation is reduced while hydroxymethylation is acquired during reprogramming of ALS patient cells. Esanov R, Belle KC, van Blitterswijk M, Belzil VV, Rademakers R, Dickson DW, Petrucelli L, Boylan KB, Dykxhoorn DM, Wuu J, Benatar M, Wahlestedt C, Zeier Z. Exp Neurol. 2016 Mar;277:171-7. doi: 10.1016/j.expneurol.2015.12.022. Epub 2015 Dec 31. PubMed |
| Haploinsufficiency of BAZ1B contributes to Williams syndrome through transcriptional dysregulation of neurodevelopmental pathways. Lalli MA, Jang J, Park JC, Wang Y, Guzman E, Zhou H, Audouard M, Bridges D, Tovar KR, Papuc SM, Tutulan-Cunita AC, Huang Y, Budisteanu M, Arghir A, Kosik KS. Hum Mol Genet. 2016 Jan 10. pii: ddw010. PubMed |
| Epithelial-to-Mesenchymal Transition of RPE Cells In Vitro Confers Increased beta1,6-N-Glycosylation and Increased Susceptibility to Galectin-3 Binding. Priglinger CS, Obermann J, Szober CM, Merl-Pham J, Ohmayer U, Behler J, Gruhn F, Kreutzer TC, Wertheimer C, Geerlof A, Priglinger SG, Hauck SM. PLoS One. 2016 Jan 13;11(1):e0146887. doi: 10.1371/journal.pone.0146887. eCollection 2016. PubMed |
| Disease causing mutations in inverted formin 2 regulate its binding to G-actin, F-actin capping protein (CapZ alpha-1) and profilin 2. Rollason R, Wherlock M, Heath JA, Heesom KJ, Saleem MA, Welsh GI. Biosci Rep. 2016 Jan 13;36(1):e00302. doi: 10.1042/BSR20150252. PubMed |
| Human pluripotent stem cell culture density modulates YAP signaling. Hsiao C, Lampe M, Nillasithanukroh S, Han W, Lian X, Palecek SP. Biotechnol J. 2016 Jan 14. doi: 10.1002/biot.201500374. PubMed |
| Oncogenic CARMA1 couples NF-kappaB and beta-catenin signaling in diffuse large B-cell lymphomas. Bognar MK, Vincendeau M, Erdmann T, Seeholzer T, Grau M, Linnemann JR, Ruland J, Scheel CH, Lenz P, Ott G, Lenz G, Hauck SM, Krappmann D. Oncogene. 2016 Jan 18. doi: 10.1038/onc.2015.493. PubMed |
| Mitofusin 2 maintains haematopoietic stem cells with extensive lymphoid potential. Luchsinger LL, de Almeida MJ, Corrigan DJ, Mumau M, Snoeck HW. Nature. 2016 Jan 28;529(7587):528-31. doi: 10.1038/nature16500. Epub 2016 Jan 20. PubMed |
| Live imaging of microtubule dynamics in organotypic hippocampal slice cultures. Schatzle P, Kapitein LC, Hoogenraad CC. Methods Cell Biol. 2016;131:107-26. doi: 10.1016/bs.mcb.2015.06.006. Epub 2015 Sep 3. PubMed |
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| Microtubules Inhibit E-Cadherin Adhesive Activity by Maintaining Phosphorylated p120-Catenin in a Colon Carcinoma Cell Model. Maiden SL, Petrova YI, Gumbiner BM. PLoS One. 2016 Feb 4;11(2):e0148574. doi: 10.1371/journal.pone.0148574. eCollection 2016. PubMed |
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| The Endoplasmic Reticulum Chaperone Calnexin Is a NADPH Oxidase NOX4 Interacting Protein. Prior KK, Wittig I, Leisegang MS, Groenendyk J, Weissmann N, Michalak M, Jansen-Durr P, Shah AM, Brandes RP. J Biol Chem. 2016 Mar 25;291(13):7045-59. doi: 10.1074/jbc.M115.710772. Epub 2016 Feb 9. PubMed |
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| Hypoxia-regulated gene expression explains differences between melanoma cell line-derived xenografts and patient-derived xenografts. Bhadury J, Einarsdottir BO, Podraza A, Bagge RO, Stierner U, Ny L, Davila Lopez M, Nilsson JA. Oncotarget. 2016 Apr 26;7(17):23801-11. doi: 10.18632/oncotarget.8181. PubMed |
| Enhancing DPYSL3 gene expression via a promoter-targeted small activating RNA approach suppresses cancer cell motility and metastasis. Li C, Jiang W, Hu Q, Li LC, Dong L, Chen R, Zhang Y, Tang Y, Thrasher JB, Liu CB, Li B. Oncotarget. 2016 Mar 23. doi: 10.18632/oncotarget.8290. PubMed |
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| Development of Third-generation Cocal Envelope Producer Cell Lines for Robust Lentiviral Gene Transfer into Hematopoietic Stem Cells and T-cells. Humbert O, Gisch DW, Wohlfahrt ME, Adams AB, Greenberg PD, Schmitt TM, Trobridge GD, Kiem HP. Mol Ther. 2016 May 24. doi: 10.1038/mt.2016.70. PubMed |
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| PPARgamma Is Activated during Congenital Cytomegalovirus Infection and Inhibits Neuronogenesis from Human Neural Stem Cells. Rolland M, Li X, Sellier Y, Martin H, Perez-Berezo T, Rauwel B, Benchoua A, Bessieres B, Aziza J, Cenac N, Luo M, Casper C, Peschanski M, Gonzalez-Dunia D, Leruez-Ville M, Davrinche C, Chavanas S. PLoS Pathog. 2016 Apr 14;12(4):e1005547. doi: 10.1371/journal.ppat.1005547. eCollection 2016 Apr. PubMed |
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| CD99 isoforms regulate CD1a expression in human monocyte-derived DCs through ATF-2/CREB-1 phosphorylation. Mahiddine K, Mallavialle A, Bziouech H, Larbret F, Bernard A, Bernard G. Eur J Immunol. 2016 Jun;46(6):1460-71. doi: 10.1002/eji.201546143. Epub 2016 May 6. PubMed |
| The Herpes Simplex Virus Virion Host Shutoff Protein Enhances Translation of Viral True Late mRNAs Independently of Suppressing Protein Kinase R and Stress Granule Formation. Dauber B, Poon D, Dos Santos T, Duguay BA, Mehta N, Saffran HA, Smiley JR. J Virol. 2016 Jun 10;90(13):6049-57. doi: 10.1128/JVI.03180-15. Print 2016 Jul 1. PubMed |
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| In Vitro Differentiation of Mouse Granulocytes. Reinhart R, Wicki S, Kaufmann T. Methods Mol Biol. 2016;1419:95-107. doi: 10.1007/978-1-4939-3581-9_8. PubMed |
| A convenient and effective strategy for the enrichment of tumor-initiating cell properties in prostate cancer cells. Zhang Y, Huang Y, Jin Z, Li X, Li B, Xu P, Huang P, Liu C. Tumour Biol. 2016 Apr 25. PubMed |
| The orphan nuclear receptor NR4A2 is part of a p53-microRNA-34 network. Beard JA, Tenga A, Hills J, Hoyer JD, Cherian MT, Wang YD, Chen T. Sci Rep. 2016 Apr 28;6:25108. doi: 10.1038/srep25108. PubMed |
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| The mitochondrial calcium uniporter regulates breast cancer progression via HIF-1alpha. Tosatto A, Sommaggio R, Kummerow C, Bentham RB, Blacker TS, Berecz T, Duchen MR, Rosato A, Bogeski I, Szabadkai G, Rizzuto R, Mammucari C. EMBO Mol Med. 2016 May 2;8(5):569-85. doi: 10.15252/emmm.201606255. PubMed |
TET2 Regulates Mast Cell Differentiation and Proliferation through Catalytic and Non-catalytic Activities.
Montagner S, Leoni C, Emming S, Della Chiara G, Balestrieri C, Barozzi I, Piccolo V, Togher S, Ko M, Rao A, Natoli G, Monticelli S.
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| The three Type 2A protein phosphatases, PP2Ac, PP4c and PP6c, are differentially regulated by Alpha4. LeNoue-Newton ML, Wadzinski BE, Spiller BW. Biochem Biophys Res Commun. 2016 Jun 17;475(1):64-9. doi: 10.1016/j.bbrc.2016.05.036. Epub 2016 May 8. PubMed |
| TFEB and TFE3 cooperate in the regulation of the innate immune response in activated macrophages. Pastore N, Brady OA, Diab HI, Martina JA, Sun L, Huynh T, Lim JA, Zare H, Raben N, Ballabio A, Puertollano R. Autophagy. 2016 May 12:1-19. PubMed |
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| The antitumor toxin CD437 is a direct inhibitor of DNA polymerase alpha. Han T, Goralski M, Capota E, Padrick SB, Kim J, Xie Y, Nijhawan D. Nat Chem Biol. 2016 Jul;12(7):511-5. doi: 10.1038/nchembio.2082. Epub 2016 May 16. PubMed |
| Fibroblast growth factor receptor 4 (FGFR4) and fibroblast growth factor 19 (FGF19) autocrine enhance breast cancer cells survival. Tiong KH, Tan BS, Choo HL, Chung FF, Hii LW, Tan SH, Khor NT, Wong SF, See SJ, Tan YF, Rosli R, Cheong SK, Leong CO. Oncotarget. 2016 Sep 6;7(36):57633-57650. doi: 10.18632/oncotarget.9328. PubMed |
| ISPD produces CDP-ribitol used by FKTN and FKRP to transfer ribitol phosphate onto alpha-dystroglycan. Gerin I, Ury B, Breloy I, Bouchet-Seraphin C, Bolsee J, Halbout M, Graff J, Vertommen D, Muccioli GG, Seta N, Cuisset JM, Dabaj I, Quijano-Roy S, Grahn A, Van Schaftingen E, Bommer GT. Nat Commun. 2016 May 19;7:11534. doi: 10.1038/ncomms11534. PubMed |
| MYC Is a Crucial Mediator of TGFbeta-Induced Invasion in Basal Breast Cancer. Cichon MA, Moruzzi ME, Shqau TA, Miller E, Mehner C, Ethier SP, Copland JA, Radisky ES, Radisky DC. Cancer Res. 2016 Jun 15;76(12):3520-30. doi: 10.1158/0008-5472.CAN-15-3465. Epub 2016 Apr 13. PubMed |
| Opposing Regulation of the EGF Receptor: A Molecular Switch Controlling Cytomegalovirus Latency and Replication. Buehler J, Zeltzer S, Reitsma J, Petrucelli A, Umashankar M, Rak M, Zagallo P, Schroeder J, Terhune S, Goodrum F. PLoS Pathog. 2016 May 24;12(5):e1005655. doi: 10.1371/journal.ppat.1005655. eCollection 2016 May. PubMed |
| Low-Affinity Neurotrophin Receptor p75 Promotes the Transduction of Targeted Lentiviral Vectors to Cholinergic Neurons of Rat Basal Forebrain. Antyborzec I, O'Leary VB, Dolly JO, Ovsepian SV. Neurotherapeutics. 2016 Oct;13(4):859-870. PubMed |
| Measuring IL-1beta Processing by Bioluminescence Sensors II: The iGLuc System. Bartok E, Kampes M, Hornung V. Methods Mol Biol. 2016;1417:97-113. doi: 10.1007/978-1-4939-3566-6_6. PubMed |
| Forced expression of Hnf4a induces hepatic gene activation through directed differentiation. Yahoo N, Pournasr B, Rostamzadeh J, Fathi F. Biochem Biophys Res Commun. 2016 Aug 5;476(4):313-8. doi: 10.1016/j.bbrc.2016.05.119. Epub 2016 May 24. PubMed |
| A C-terminally truncated mouse Best3 splice variant targets and alters the ion balance in lysosome-endosome hybrids and the endoplasmic reticulum. Wu L, Sun Y, Ma L, Zhu J, Zhang B, Pan Q, Li Y, Liu H, Diao A, Li Y. Sci Rep. 2016 Jun 6;6:27332. doi: 10.1038/srep27332. PubMed |
| Atg7 suppression enhances chemotherapeutic agent sensitivity and overcomes stroma-mediated chemoresistance in acute myeloid leukemia. Piya S, Kornblau SM, Ruvolo VR, Mu H, Ruvolo PP, McQueen T, Davis RE, Hail N Jr, Kantarjian H, Andreeff M, Borthakur G. Blood. 2016 Jun 7. pii: blood-2016-01-692244. PubMed |
| shRNA-Induced Gene Knockdown In Vivo to Investigate Neutrophil Function. Basit A, Tang W, Wu D. Methods Mol Biol. 2016;1407:169-77. doi: 10.1007/978-1-4939-3480-5_13. PubMed |
Co-repressor CBFA2T2 regulates pluripotency and germline development.
Tu S, Narendra V, Yamaji M, Vidal SE, Rojas LA, Wang X, Kim SY, Garcia BA, Tuschl T, Stadtfeld M, Reinberg D.
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| Cell-death-inducing DFFA-like Effector B Contributes to the Assembly of Hepatitis C Virus (HCV) Particles and Interacts with HCV NS5A. Cai H, Yao W, Li L, Li X, Hu L, Mai R, Peng T. Sci Rep. 2016 Jun 10;6:27778. doi: 10.1038/srep27778. PubMed |
| TMEM16F Regulates Baseline Phosphatidylserine Exposure and Cell Viability in Human Embryonic Kidney Cells. Schenk LK, Schulze U, Henke S, Weide T, Pavenstadt H. Cell Physiol Biochem. 2016;38(6):2452-63. doi: 10.1159/000445596. Epub 2016 Jun 13. PubMed |
| N-cadherin is Key to Expression of the Nucleus Pulposus Cell Phenotype under Selective Substrate Culture Conditions. Hwang PY, Jing L, Chen J, Lim FL, Tang R, Choi H, Cheung KM, Risbud MV, Gersbach CA, Guilak F, Leung VY, Setton LA. Sci Rep. 2016 Jun 13;6:28038. doi: 10.1038/srep28038. PubMed |
| Suppression of Spleen Tyrosine Kinase (Syk) by Histone Deacetylation Promotes, Whereas BAY61-3606, a Synthetic Syk Inhibitor Abrogates Colonocyte Apoptosis by ERK Activation. Dasgupta N, Thakur BK, Ta A, Dutta P, Das S. J Cell Biochem. 2016 Jun 13. doi: 10.1002/jcb.25625. PubMed |
| MicroRNA-181b inhibits thrombin-mediated endothelial activation and arterial thrombosis by targeting caspase recruitment domain family member 10. Lin J, He S, Sun X, Franck G, Deng Y, Yang D, Haemmig S, Wara AK, Icli B, Li D, Feinberg MW. FASEB J. 2016 Jun 13. pii: fj.201500163R. PubMed |
| The Rac-GAP alpha2-chimaerin regulates hippocampal dendrite and spine morphogenesis. Valdez CM, Murphy GG, Beg AA. Mol Cell Neurosci. 2016 Jun 11;75:14-26. doi: 10.1016/j.mcn.2016.06.002. PubMed |
| Engineering of Isogenic Cells Deficient for MR1 with a CRISPR/Cas9 Lentiviral System: Tools To Study Microbial Antigen Processing and Presentation to Human MR1-Restricted T Cells. Laugel B, Lloyd A, Meermeier EW, Crowther MD, Connor TR, Dolton G, Miles JJ, Burrows SR, Gold MC, Lewinsohn DM, Sewell AK. J Immunol. 2016 Jun 15. pii: 1501402. PubMed |
| Preventing Plasmon Coupling between Gold Nanorods Improves the Sensitivity of Photoacoustic Detection of Labeled Stem Cells in Vivo. Comenge J, Fragueiro O, Sharkey J, Taylor A, Held M, Burton NC, Park BK, Wilm B, Murray P, Brust M, Levy R. ACS Nano. 2016 Jul 26;10(7):7106-16. doi: 10.1021/acsnano.6b03246. Epub 2016 Jun 20. PubMed |
AMPK-SKP2-CARM1 signalling cascade in transcriptional regulation of autophagy.
Shin HR, Kim H, Oh S, Lee JG, Kee M, Ko HJ, Kweon MN, Won KJ, Baek SH.
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| Autophagy regulates spermatid differentiation via degradation of PDLIM1. Shang Y, Wang H, Jia P, Zhao H, Liu C, Liu W, Song Z, Xu Z, Yang L, Wang Y, Li W. Autophagy. 2016 Sep;12(9):1575-92. doi: 10.1080/15548627.2016.1192750. Epub 2016 Jun 16. PubMed |
| Hypoxia promotes noncanonical autophagy in nucleus pulposus cells independent of MTOR and HIF1A signaling. Choi H, Merceron C, Mangiavini L, Seifert EL, Schipani E, Shapiro IM, Risbud MV. Autophagy. 2016 Sep;12(9):1631-46. doi: 10.1080/15548627.2016.1192753. Epub 2016 Jun 17. PubMed |
| Conditional RNAi Using the Lentiviral GLTR System. Pfeiffenberger E, Sigl R, Geley S. Methods Mol Biol. 2016;1448:121-38. doi: 10.1007/978-1-4939-3753-0_10. PubMed |
| Dynamic Imaging Reveals Coordinate Effects of Cyclic Stretch and Substrate Stiffness on Endothelial Integrity. Dan A, Huang RB, Leckband DE. Ann Biomed Eng. 2016 Jun 17. PubMed |
| Chromatin remodeling gene AT-rich interactive domain-containing protein 1A suppresses gastric cancer cell proliferation by targeting PIK3CA and PDK1. Zhang Q, Yan HB, Wang J, Cui SJ, Wang XQ, Jiang YH, Feng L, Yang PY, Liu F. Oncotarget. 2016 Jul 19;7(29):46127-46141. doi: 10.18632/oncotarget.10060. PubMed |
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| Fluorescence Reporter-Based Genome-Wide RNA Interference Screening to Identify Alternative Splicing Regulators. Misra A, Green MR. Methods Mol Biol. 2017;1507:1-12. PubMed |
| Notch regulates BMP responsiveness and lateral branching in vessel networks via SMAD6. Mouillesseaux KP, Wiley DS, Saunders LM, Wylie LA, Kushner EJ, Chong DC, Citrin KM, Barber AT, Park Y, Kim JD, Samsa LA, Kim J, Liu J, Jin SW, Bautch VL. Nat Commun. 2016 Nov 11;7:13247. doi: 10.1038/ncomms13247. PubMed |
| Targeted depletion of PIK3R2 induces regression of lung squamous cell carcinoma. Vallejo-Diaz J, Olazabal-Moran M, Cariaga-Martinez AE, Pajares MJ, Flores JM, Pio R, Montuenga LM, Carrera AC. Oncotarget. 2016 Dec 20;7(51):85063-85078. doi: 10.18632/oncotarget.13195. PubMed |
| A Highly Conserved Residue in HIV-1 Nef Alpha Helix 2 Modulates Protein Expression. Johnson AL, Dirk BS, Coutu M, Haeryfar SM, Arts EJ, Finzi A, Dikeakos JD. mSphere. 2016 Nov 9;1(6). pii: e00288-16. eCollection 2016 Nov-Dec. PubMed |
| Tumors overexpressing RNF168 show altered DNA repair and responses to genotoxic treatments, genomic instability and resistance to proteotoxic stress. Chroma K, Mistrik M, Moudry P, Gursky J, Liptay M, Strauss R, Skrott Z, Vrtel R, Bartkova J, Kramara J, Bartek J. Oncogene. 2016 Nov 14. doi: 10.1038/onc.2016.392. PubMed |
| Dual loss of succinate dehydrogenase (SDH) and complex I activity is necessary to recapitulate the metabolic phenotype of SDH mutant tumors. Lorendeau D, Rinaldi G, Boon R, Spincemaille P, Metzger K, Jager C, Christen S, Dong X, Kuenen S, Voordeckers K, Verstreken P, Cassiman D, Vermeersch P, Verfaillie C, Hiller K, Fendt SM. Metab Eng. 2016 Nov 12. pii: S1096-7176(16)30217-8. doi: 10.1016/j.ymben.2016.11.005. PubMed |
In vivo genome editing via CRISPR/Cas9 mediated homology-independent targeted integration.
Suzuki K, Tsunekawa Y, Hernandez-Benitez R, Wu J, Zhu J, Kim EJ, Hatanaka F, Yamamoto M, Araoka T, Li Z, Kurita M, Hishida T, Li M, Aizawa E, Guo S, Chen S, Goebl A, Soligalla RD, Qu J, Jiang T, Fu X, Jafari M, Esteban CR, Berggren WT, Lajara J, Nunez-Delicado E, Guillen P, Campistol JM, Matsuzaki F, Liu GH, Magistretti P, Zhang K, Callaway EM, Zhang K, Belmonte JC.
Nature. 2016 Dec 1;540(7631):144-149. doi: 10.1038/nature20565. Epub 2016 Nov 16.
PubMed
Associated Plasmids |
| SPRTN is a mammalian DNA-binding metalloprotease that resolves DNA-protein crosslinks. Lopez-Mosqueda J, Maddi K, Prgomet S, Kalayil S, Marinovic-Terzic I, Terzic J, Dikic I. Elife. 2016 Nov 17;5. pii: e21491. doi: 10.7554/eLife.21491. PubMed |
| Knockdown of PTRF ameliorates adipocyte differentiation and functionality of human mesenchymal stem cells. Perez-Diaz S, Garcia-Rodriguez B, Gonzalez-Irazabal Y, Valero M, Lagos-Lizan J, Arbones-Mainar JM. Am J Physiol Cell Physiol. 2017 Jan 1;312(1):C83-C91. doi: 10.1152/ajpcell.00246.2016. Epub 2016 Nov 16. PubMed |
| miRNAsong: a web-based tool for generation and testing of miRNA sponge constructs in silico. Barta T, Peskova L, Hampl A. Sci Rep. 2016 Nov 18;6:36625. doi: 10.1038/srep36625. PubMed |
| Low p16INK4a Expression in Early Passage Human Prostate Basal Epithelial Cells Enables Immortalization by Telomerase Expression Alone. Graham MK, Principessa L, Antony L, Meeker AK, Isaacs JT. Prostate. 2016 Nov 8. doi: 10.1002/pros.23276. PubMed |
| Modularized Gold Nanocarriers for TAT-Mediated Delivery of siRNA. Huang X, Lai Y, Braun GB, Reich NO. Small. 2016 Nov 18. doi: 10.1002/smll.201602473. PubMed |
| Epigenetic Activation of WNT5A Drives Glioblastoma Stem Cell Differentiation and Invasive Growth. Hu B, Wang Q, Wang YA, Hua S, Sauve CG, Ong D, Lan ZD, Chang Q, Ho YW, Monasterio MM, Lu X, Zhong Y, Zhang J, Deng P, Tan Z, Wang G, Liao WT, Corley LJ, Yan H, Zhang J, You Y, Liu N, Cai L, Finocchiaro G, Phillips JJ, Berger MS, Spring DJ, Hu J, Sulman EP, Fuller GN, Chin L, Verhaak RG, DePinho RA. Cell. 2016 Nov 17;167(5):1281-1295.e18. doi: 10.1016/j.cell.2016.10.039. PubMed |
| Emerin suppresses Notch signaling by restricting the Notch intracellular domain to the nuclear membrane. Lee B, Lee TH, Shim J. Biochim Biophys Acta. 2017 Feb;1864(2):303-313. doi: 10.1016/j.bbamcr.2016.11.013. Epub 2016 Nov 16. PubMed |
| Pan-cancer analysis of somatic copy-number alterations implicates IRS4 and IGF2 in enhancer hijacking. Weischenfeldt J, Dubash T, Drainas AP, Mardin BR, Chen Y, Stutz AM, Waszak SM, Bosco G, Halvorsen AR, Raeder B, Efthymiopoulos T, Erkek S, Siegl C, Brenner H, Brustugun OT, Dieter SM, Northcott PA, Petersen I, Pfister SM, Schneider M, Solberg SK, Thunissen E, Weichert W, Zichner T, Thomas R, Peifer M, Helland A, Ball CR, Jechlinger M, Sotillo R, Glimm H, Korbel JO. Nat Genet. 2017 Jan;49(1):65-74. doi: 10.1038/ng.3722. Epub 2016 Nov 21. PubMed |
| RNA Sequencing Reveals a Role of TonEBP Transcription Factor in Regulation of Pro-inflammatory Genes in Response to Hyperosmolarity in Healthy Nucleus Pulposus Cells: A HOMEOSTATIC RESPONSE? Johnson ZI, Shapiro IM, Risbud MV. J Biol Chem. 2016 Dec 23;291(52):26686-26697. doi: 10.1074/jbc.M116.757732. Epub 2016 Nov 8. PubMed |
| Merkel Cell Polyomavirus Small T Antigen Promotes Pro-Glycolytic Metabolic Perturbations Required for Transformation. Berrios C, Padi M, Keibler MA, Park DE, Molla V, Cheng J, Lee SM, Stephanopoulos G, Quackenbush J, DeCaprio JA. PLoS Pathog. 2016 Nov 23;12(11):e1006020. doi: 10.1371/journal.ppat.1006020. eCollection 2016 Nov. PubMed |
| Cell-Type-Specific Chromatin States Differentially Prime Squamous Cell Carcinoma Tumor-Initiating Cells for Epithelial to Mesenchymal Transition. Latil M, Nassar D, Beck B, Boumahdi S, Wang L, Brisebarre A, Dubois C, Nkusi E, Lenglez S, Checinska A, Vercauteren Drubbel A, Devos M, Declercq W, Yi R, Blanpain C. Cell Stem Cell. 2016 Nov 16. pii: S1934-5909(16)30359-9. doi: 10.1016/j.stem.2016.10.018. PubMed |
| The anti-tumor drug 2-hydroxyoleic acid (Minerval) stimulates signaling and retrograde transport. Torgersen ML, Klokk TI, Kavaliauskiene S, Klose C, Simons K, Skotland T, Sandvig K. Oncotarget. 2016 Dec 27;7(52):86871-86888. doi: 10.18632/oncotarget.13508. PubMed |
| Scleraxis is essential for tendon differentiation by equine embryonic stem cells and in equine fetal tenocytes. Bavin E, Atkinson F, Barsby T, Guest D. Stem Cells Dev. 2016 Nov 29. PubMed |
| Molecular imaging with engineered physiology. Desai M, Slusarczyk AL, Chapin A, Barch M, Jasanoff A. Nat Commun. 2016 Dec 2;7:13607. doi: 10.1038/ncomms13607. PubMed |
| The tumor suppressor FLCN mediates an alternate mTOR pathway to regulate browning of adipose tissue. Wada S, Neinast M, Jang C, Ibrahim YH, Lee G, Babu A, Li J, Hoshino A, Rowe GC, Rhee J, Martina JA, Puertollano R, Blenis J, Morley M, Baur JA, Seale P, Arany Z. Genes Dev. 2016 Nov 15;30(22):2551-2564. Epub 2016 Dec 2. PubMed |
Young adult born neurons enhance hippocampal dependent performance via influences on bilateral networks.
Zhuo JM, Tseng HA, Desai M, Bucklin ME, Mohammed AI, Robinson NT, Boyden ES, Rangel LM, Jasanoff AP, Gritton HJ, Han X.
Elife. 2016 Dec 3;5. pii: e22429. doi: 10.7554/eLife.22429.
PubMed
Associated Plasmids |
| Tuberous sclerosis complex inactivation disrupts melanogenesis via mTORC1 activation. Cao J, Tyburczy ME, Moss J, Darling TN, Widlund HR, Kwiatkowski DJ. J Clin Invest. 2017 Jan 3;127(1):349-364. doi: 10.1172/JCI84262. Epub 2016 Dec 5. PubMed |
| hMYH and hMTH1 cooperate for survival in mismatch repair defective T-cell acute lymphoblastic leukemia. Eshtad S, Mavajian Z, Rudd SG, Visnes T, Bostrom J, Altun M, Helleday T. Oncogenesis. 2016 Dec 5;5(12):e275. doi: 10.1038/oncsis.2016.72. PubMed |
| Acidic tumor microenvironment abrogates the efficacy of mTORC1 inhibitors. Faes S, Duval AP, Planche A, Uldry E, Santoro T, Pythoud C, Stehle JC, Horlbeck J, Letovanec I, Riggi N, Demartines N, Dormond O. Mol Cancer. 2016 Dec 5;15(1):78. PubMed |
| PET imaging-guided chemogenetic silencing reveals a critical role of primate rostromedial caudate in reward evaluation. Nagai Y, Kikuchi E, Lerchner W, Inoue KI, Ji B, Eldridge MA, Kaneko H, Kimura Y, Oh-Nishi A, Hori Y, Kato Y, Hirabayashi T, Fujimoto A, Kumata K, Zhang MR, Aoki I, Suhara T, Higuchi M, Takada M, Richmond BJ, Minamimoto T. Nat Commun. 2016 Dec 6;7:13605. doi: 10.1038/ncomms13605. PubMed |
| SFPQ*NONO and XLF function separately and together to promote DNA double-strand break repair via canonical nonhomologous end joining. Jaafar L, Li Z, Li S, Dynan WS. Nucleic Acids Res. 2016 Dec 6. pii: gkw1209. PubMed |
| EGF induces epithelial-mesenchymal transition and cancer stem-like cell properties in human oral cancer cells via promoting Warburg effect. Xu Q, Zhang Q, Ishida Y, Hajjar S, Tang X, Shi H, Dang CV, Le AD. Oncotarget. 2017 Feb 7;8(6):9557-9571. doi: 10.18632/oncotarget.13771. PubMed |
| Proteome-Scale Investigation of Protein Allosteric Regulation Perturbed by Somatic Mutations in 7,000 Cancer Genomes. Shen Q, Cheng F, Song H, Lu W, Zhao J, An X, Liu M, Chen G, Zhao Z, Zhang J. Am J Hum Genet. 2017 Jan 5;100(1):5-20. doi: 10.1016/j.ajhg.2016.09.020. Epub 2016 Dec 8. PubMed |
| Fyn kinase regulates translation in mammalian mitochondria. Koc EC, Miller-Lee JL, Koc H. Biochim Biophys Acta. 2017 Mar;1861(3):533-540. doi: 10.1016/j.bbagen.2016.12.004. Epub 2016 Dec 7. PubMed |
| Different Use of Cell Surface Glycosaminoglycans As Adherence Receptors to Corneal Cells by Gram Positive and Gram Negative Pathogens. Garcia B, Merayo-Lloves J, Rodriguez D, Alcalde I, Garcia-Suarez O, Alfonso JF, Baamonde B, Fernandez-Vega A, Vazquez F, Quiros LM. Front Cell Infect Microbiol. 2016 Nov 30;6:173. eCollection 2016. PubMed |
| CD63 regulates Epstein-Barr virus LMP1 exosomal packaging, enhancement of vesicle production, and non-canonical NF-kappaB signaling. Hurwitz SN, Nkosi D, Conlon MM, York SB, Liu X, Tremblay DC, Meckes DG Jr. J Virol. 2016 Dec 14. pii: JVI.02251-16. PubMed |
Perturb-Seq: Dissecting Molecular Circuits with Scalable Single-Cell RNA Profiling of Pooled Genetic Screens.
Dixit A, Parnas O, Li B, Chen J, Fulco CP, Jerby-Arnon L, Marjanovic ND, Dionne D, Burks T, Raychowdhury R, Adamson B, Norman TM, Lander ES, Weissman JS, Friedman N, Regev A.
Cell. 2016 Dec 15;167(7):1853-1866.e17. doi: 10.1016/j.cell.2016.11.038.
PubMed
Associated Plasmids |
| Caspase-2-mediated cell death is required for deleting aneuploid cells. Dawar S, Lim Y, Puccini J, White M, Thomas P, Bouchier-Hayes L, Green DR, Dorstyn L, Kumar S. Oncogene. 2016 Dec 19. doi: 10.1038/onc.2016.423. PubMed |
| Ras oncogene-independent activation of RALB signaling is a targetable mechanism of escape from NRAS(V12) oncogene addiction in acute myeloid leukemia. Pomeroy EJ, Lee LA, Lee RD, Schirm DK, Temiz NA, Ma J, Gruber TA, Diaz-Flores E, Moriarity BS, Downing JR, Shannon KM, Largaespada DA, Eckfeldt CE. Oncogene. 2016 Dec 19. doi: 10.1038/onc.2016.471. PubMed |
In vivo high-throughput profiling of CRISPR-Cpf1 activity.
Kim HK, Song M, Lee J, Menon AV, Jung S, Kang YM, Choi JW, Woo E, Koh HC, Nam JW, Kim H.
Nat Methods. 2016 Dec 19. doi: 10.1038/nmeth.4104.
PubMed
Associated Plasmids |
| A Photoactivatable Innate Immune Receptor for Optogenetic Inflammation. Moser BA, Esser-Kahn AP. ACS Chem Biol. 2016 Dec 29. doi: 10.1021/acschembio.6b01012. PubMed |
| Nuclear Localization of Integrin Cytoplasmic Associated Protein-1 Influences beta1 Integrin Activation and Recruits Krev/ Interaction Trapped-1 to the Nucleus. Draheim KM, Huet-Calderwood C, Simon B, Calderwood DA. J Biol Chem. 2016 Dec 21. pii: jbc.M116.762393. doi: 10.1074/jbc.M116.762393. PubMed |
| Metabolic Characterization of Intact Cells Reveals Intracellular Amyloid Beta but Not Its Precursor Protein to Reduce Mitochondrial Respiration. Schaefer PM, von Einem B, Walther P, Calzia E, von Arnim CA. PLoS One. 2016 Dec 22;11(12):e0168157. doi: 10.1371/journal.pone.0168157. eCollection 2016. PubMed |
| Zika virus infection induces mitosis abnormalities and apoptotic cell death of human neural progenitor cells. Souza BS, Sampaio GL, Pereira CS, Campos GS, Sardi SI, Freitas LA, Figueira CP, Paredes BD, Nonaka CK, Azevedo CM, Rocha VP, Bandeira AC, Mendez-Otero R, Dos Santos RR, Soares MB. Sci Rep. 2016 Dec 23;6:39775. doi: 10.1038/srep39775. PubMed |
| An enzymatic assay based on luciferase Ebola virus-like particles for evaluation of virolytic activity of antimicrobial peptides. Peskova M, Heger Z, Janda P, Adam V, Pekarik V. Peptides. 2016 Dec 22;88:87-96. doi: 10.1016/j.peptides.2016.12.015. PubMed |
| Prohibitin 2 Is an Inner Mitochondrial Membrane Mitophagy Receptor. Wei Y, Chiang WC, Sumpter R Jr, Mishra P, Levine B. Cell. 2017 Jan 12;168(1-2):224-238.e10. doi: 10.1016/j.cell.2016.11.042. Epub 2016 Dec 22. PubMed |
| Non-human Primate Schlafen11 Inhibits Production of Both Host and Viral Proteins. Stabell AC, Hawkins J, Li M, Gao X, David M, Press WH, Sawyer SL. PLoS Pathog. 2016 Dec 27;12(12):e1006066. doi: 10.1371/journal.ppat.1006066. eCollection 2016 Dec. PubMed |
| Proteins that interact with calgranulin B in the human colon cancer cell line HCT-116. Myung JK, Yeo SG, Kim KH, Baek KS, Shin D, Kim JH, Cho JY, Yoo BC. Oncotarget. 2017 Jan 24;8(4):6819-6832. doi: 10.18632/oncotarget.14301. PubMed |
Inhibition of CRISPR-Cas9 with Bacteriophage Proteins.
Rauch BJ, Silvis MR, Hultquist JF, Waters CS, McGregor MJ, Krogan NJ, Bondy-Denomy J.
Cell. 2016 Dec 22. pii: S0092-8674(16)31683-X. doi: 10.1016/j.cell.2016.12.009.
PubMed
Associated Plasmids |
| Nipbl Interacts with Zfp609 and the Integrator Complex to Regulate Cortical Neuron Migration. van den Berg DL, Azzarelli R, Oishi K, Martynoga B, Urban N, Dekkers DH, Demmers JA, Guillemot F. Neuron. 2016 Dec 20. pii: S0896-6273(16)30915-1. doi: 10.1016/j.neuron.2016.11.047. PubMed |
| Rational Design of Selective Allosteric Inhibitors of PHGDH and Serine Synthesis with Anti-tumor Activity. Wang Q, Liberti MV, Liu P, Deng X, Liu Y, Locasale JW, Lai L. Cell Chem Biol. 2016 Dec 20. pii: S2451-9456(16)30436-6. doi: 10.1016/j.chembiol.2016.11.013. PubMed |
| Cytosolic Fc receptor TRIM21 inhibits seeded tau aggregation. McEwan WA, Falcon B, Vaysburd M, Clift D, Oblak AL, Ghetti B, Goedert M, James LC. Proc Natl Acad Sci U S A. 2017 Jan 17;114(3):574-579. doi: 10.1073/pnas.1607215114. Epub 2017 Jan 3. PubMed |
| A screen for Fli-1 transcriptional modulators identifies PKC agonists that induce erythroid to megakaryocytic differentiation and suppress leukemogenesis. Liu T, Yao Y, Zhang G, Wang Y, Deng B, Song J, Li X, Han F, Xiao X, Yang J, Xia L, Li YJ, Plachynta M, Zhang M, Yan C, Mu S, Luo H, Zacksenhaus E, Hao X, Ben-David Y. Oncotarget. 2017 Mar 7;8(10):16728-16743. doi: 10.18632/oncotarget.14377. PubMed |
| Reprogramming Mouse Embryonic Fibroblasts with Transcription Factors to Induce a Hemogenic Program. Daniel MG, Pereira CF, Bernitz JM, Lemischka IR, Moore K. J Vis Exp. 2016 Dec 16;(118). doi: 10.3791/54372. PubMed |
| Annexin A8 promotes VEGF-A driven endothelial cell sprouting. Heitzig N, Brinkmann BF, Koerdt SN, Rosso G, Shahin V, Rescher U. Cell Adh Migr. 2017 Jan 6:1-13. doi: 10.1080/19336918.2016.1264559. PubMed |
| Oxidized nucleotide insertion by pol beta confounds ligation during base excision repair. Caglayan M, Horton JK, Dai DP, Stefanick DF, Wilson SH. Nat Commun. 2017 Jan 9;8:14045. doi: 10.1038/ncomms14045. PubMed |
| APC/C Dysfunction Limits Excessive Cancer Chromosomal Instability. Sansregret L, Patterson JO, Dewhurst S, Lopez-Garcia C, Koch A, McGranahan N, Chao WC, Barry DJ, Rowan A, Instrell R, Horswell S, Way M, Howell M, Singleton MR, Medema RH, Nurse P, Petronczki M, Swanton C. Cancer Discov. 2017 Jan 9. doi: 10.1158/2159-8290.CD-16-0645. PubMed |
| Highly Expandable Human iPS Cell-Derived Neural Progenitor Cells (NPC) and Neurons for Central Nervous System Disease Modeling and High-Throughput Screening. Cheng C, Fass DM, Folz-Donahue K, MacDonald ME, Haggarty SJ. Curr Protoc Hum Genet. 2017 Jan 11;92:21.8.1-21.8.21. doi: 10.1002/cphg.33. PubMed |
| Translation from unconventional 5' start sites drives tumour initiation. Sendoel A, Dunn JG, Rodriguez EH, Naik S, Gomez NC, Hurwitz B, Levorse J, Dill BD, Schramek D, Molina H, Weissman JS, Fuchs E. Nature. 2017 Jan 26;541(7638):494-499. doi: 10.1038/nature21036. Epub 2017 Jan 11. PubMed |
| Alternative lengthening of telomeres can be maintained by preferential elongation of lagging strands. Min J, Wright WE, Shay JW. Nucleic Acids Res. 2017 Mar 17;45(5):2615-2628. doi: 10.1093/nar/gkw1295. PubMed |
| The E3 ubiquitin ligase NEDD4 is an LC3-interactive protein and regulates autophagy. Sun A, Wei J, Childress C, Shaw JH 4th, Peng K, Shao G, Yang W, Lin Q. Autophagy. 2017 Mar 4;13(3):522-537. doi: 10.1080/15548627.2016.1268301. Epub 2017 Jan 13. PubMed |
| De-immunized and Functional Therapeutic (DeFT) versions of a long lasting recombinant alpha interferon for antiviral therapy. Mufarrege EF, Giorgetti S, Etcheverrigaray M, Terry F, Martin W, De Groot AS. Clin Immunol. 2017 Jan 10;176:31-41. doi: 10.1016/j.clim.2017.01.003. PubMed |
| Human AML-iPSCs Reacquire Leukemic Properties after Differentiation and Model Clonal Variation of Disease. Chao MP, Gentles AJ, Chatterjee S, Lan F, Reinisch A, Corces MR, Xavy S, Shen J, Haag D, Chanda S, Sinha R, Morganti RM, Nishimura T, Ameen M, Wu H, Wernig M, Wu JC, Majeti R. Cell Stem Cell. 2017 Mar 2;20(3):329-344.e7. doi: 10.1016/j.stem.2016.11.018. Epub 2017 Jan 12. PubMed |
| Glioblastoma Cancer Stem Cells Evade Innate Immune Suppression of Self-Renewal through Reduced TLR4 Expression. Alvarado AG, Thiagarajan PS, Mulkearns-Hubert EE, Silver DJ, Hale JS, Alban TJ, Turaga SM, Jarrar A, Reizes O, Longworth MS, Vogelbaum MA, Lathia JD. Cell Stem Cell. 2017 Apr 6;20(4):450-461.e4. doi: 10.1016/j.stem.2016.12.001. Epub 2017 Jan 12. PubMed |
| Systematic evaluation of markers used for the identification of human induced pluripotent stem cells. Bharathan SP, Manian KV, Aalam SM, Palani D, Deshpande PA, Pratheesh MD, Srivastava A, Velayudhan SR. Biol Open. 2017 Jan 15;6(1):100-108. doi: 10.1242/bio.022111. PubMed |
| JunB regulates angiogenesis and neurovascular parallel alignment in mouse embryonic skin. Yoshitomi Y, Ikeda T, Saito H, Yoshitake Y, Ishigaki Y, Hatta T, Kato N, Yonekura H. J Cell Sci. 2017 Mar 1;130(5):916-926. doi: 10.1242/jcs.196303. Epub 2017 Jan 17. PubMed |
| Dopamine promotes NMDA receptor hypofunction in the retina through D1 receptor-mediated Csk activation, Src inhibition and decrease of GluN2B phosphorylation. Socodato R, Santiago FN, Portugal CC, Domith I, Encarnacao TG, Loiola EC, Ventura AL, Cossenza M, Relvas JB, Castro NG, Paes-de-Carvalho R. Sci Rep. 2017 Jan 18;7:40912. doi: 10.1038/srep40912. PubMed |
Pooled CRISPR screening with single-cell transcriptome readout.
Datlinger P, Rendeiro AF, Schmidl C, Krausgruber T, Traxler P, Klughammer J, Schuster LC, Kuchler A, Alpar D, Bock C.
Nat Methods. 2017 Jan 18. doi: 10.1038/nmeth.4177.
PubMed
Associated Plasmids |
| TRIM8 regulates stemness in glioblastoma through PIAS3-STAT3. Zhang C, Mukherjee S, Tucker-Burden C, Ross JL, Chau MJ, Kong J, Brat DJ. Mol Oncol. 2017 Mar;11(3):280-294. doi: 10.1002/1878-0261.12034. Epub 2017 Feb 15. PubMed |
| Lysosome-Dependent Activation of Human Dendritic Cells by the Vaccine Adjuvant QS-21. Welsby I, Detienne S, N'Kuli F, Thomas S, Wouters S, Bechtold V, De Wit D, Gineste R, Reinheckel T, Elouahabi A, Courtoy PJ, Didierlaurent AM, Goriely S. Front Immunol. 2017 Jan 5;7:663. doi: 10.3389/fimmu.2016.00663. eCollection 2016. PubMed |
| Psoriasin has divergent effects on the innate immune responses of murine glial cells. Jansen S, Kress E, Fragoulis A, Wruck CJ, Wolf R, Grotzinger J, Michalek M, Pufe T, Tauber SC, Brandenburg LO. J Neurochem. 2017 Apr;141(1):86-99. doi: 10.1111/jnc.13959. Epub 2017 Feb 27. PubMed |
An Argonaute phosphorylation cycle promotes microRNA-mediated silencing.
Golden RJ, Chen B, Li T, Braun J, Manjunath H, Chen X, Wu J, Schmid V, Chang TC, Kopp F, Ramirez-Martinez A, Tagliabracci VS, Chen ZJ, Xie Y, Mendell JT.
Nature. 2017 Feb 9;542(7640):197-202. doi: 10.1038/nature21025. Epub 2017 Jan 23.
PubMed
Associated Plasmids |
| Interaction with ZMYND11 mediates opposing roles of Ras-responsive transcription factors ETS1 and ETS2. Plotnik JP, Hollenhorst PC. Nucleic Acids Res. 2017 May 5;45(8):4452-4462. doi: 10.1093/nar/gkx039. PubMed |
| Nectin-like 4 Complexes with Choline Transporter-like Protein-1 and Regulates Schwann Cell Choline Homeostasis and Lipid Biogenesis in Vitro. Heffernan C, Jain MR, Liu T, Kim H, Barretto K, Li H, Maurel P. J Biol Chem. 2017 Mar 17;292(11):4484-4498. doi: 10.1074/jbc.M116.747816. Epub 2017 Jan 24. PubMed |
| Physiologic and genetic evidence links hemopexin to triglycerides in mice and humans. Lawson HA, Zayed M, Wayhart JP, Fabbrini E, Love-Gregory L, Klein S, Semenkovich CF. Int J Obes (Lond). 2017 Apr;41(4):631-638. doi: 10.1038/ijo.2017.19. Epub 2017 Jan 25. PubMed |
| The Genetic Basis of Hepatosplenic T-cell Lymphoma. McKinney M, Moffitt AB, Gaulard P, Travert M, De Leval L, Nicolae A, Raffeld M, Jaffe ES, Pittaluga S, Xi L, Heavican T, Iqbal J, Belhadj K, Delfau-Larue MH, Fataccioli V, Czader MB, Lossos IS, Chapman-Fredricks JR, Richards KL, Fedoriw Y, Ondrejka SL, Hsi ED, Low L, Weisenburger D, Chan WC, Mehta-Shah N, Horwitz S, Bernal-Mizrachi L, Flowers CR, Beaven AW, Parihar M, Baseggio L, Parrens M, Moreau A, Sujobert P, Pilichowska M, Evens AM, Chadburn A, Au-Yeung RK, Srivastava G, Choi WW, Goodlad JR, Aurer I, Basic-Kinda S, Gascoyne RD, Davis NS, Li G, Zhang J, Rajagopalan D, Reddy A, Love C, Levy S, Zhuang Y, Datta J, Dunson DB, Dave SS. Cancer Discov. 2017 Apr;7(4):369-379. doi: 10.1158/2159-8290.CD-16-0330. Epub 2017 Jan 25. PubMed |
| Interspecies Chimerism with Mammalian Pluripotent Stem Cells. Wu J, Platero-Luengo A, Sakurai M, Sugawara A, Gil MA, Yamauchi T, Suzuki K, Bogliotti YS, Cuello C, Morales Valencia M, Okumura D, Luo J, Vilarino M, Parrilla I, Soto DA, Martinez CA, Hishida T, Sanchez-Bautista S, Martinez-Martinez ML, Wang H, Nohalez A, Aizawa E, Martinez-Redondo P, Ocampo A, Reddy P, Roca J, Maga EA, Esteban CR, Berggren WT, Nunez Delicado E, Lajara J, Guillen I, Guillen P, Campistol JM, Martinez EA, Ross PJ, Izpisua Belmonte JC. Cell. 2017 Jan 26;168(3):473-486.e15. doi: 10.1016/j.cell.2016.12.036. PubMed |
| Mutations in tropomyosin 4 underlie a rare form of human macrothrombocytopenia. Pleines I, Woods J, Chappaz S, Kew V, Foad N, Ballester-Beltran J, Aurbach K, Lincetto C, Lane RM, Schevzov G, Alexander WS, Hilton DJ, Astle WJ, Downes K, Nurden P, Westbury SK, Mumford AD, Obaji SG, Collins PW, Delerue F, Ittner LM, Bryce NS, Holliday M, Lucas CA, Hardeman EC, Ouwehand WH, Gunning PW, Turro E, Tijssen MR, Kile BT. J Clin Invest. 2017 Mar 1;127(3):814-829. doi: 10.1172/JCI86154. Epub 2017 Jan 30. PubMed |
| Mouse Stbd1 is N-myristoylated and affects ER-mitochondria association and mitochondrial morphology. Demetriadou A, Morales-Sanfrutos J, Nearchou M, Baba O, Kyriacou K, Tate EW, Drousiotou A, Petrou PP. J Cell Sci. 2017 Mar 1;130(5):903-915. doi: 10.1242/jcs.195263. Epub 2017 Jan 30. PubMed |
| Visualization of aging-associated chromatin alterations with an engineered TALE system. Ren R, Deng L, Xue Y, Suzuki K, Zhang W, Yu Y, Wu J, Sun L, Gong X, Luan H, Yang F, Ju Z, Ren X, Wang S, Tang H, Geng L, Zhang W, Li J, Qiao J, Xu T, Qu J, Liu GH. Cell Res. 2017 Apr;27(4):483-504. doi: 10.1038/cr.2017.18. Epub 2017 Jan 31. PubMed |
| Metalloprotease-disintegrin ADAM12 actively promotes the stem cell-like phenotype in claudin-low breast cancer. Duhachek-Muggy S, Qi Y, Wise R, Alyahya L, Li H, Hodge J, Zolkiewska A. Mol Cancer. 2017 Feb 1;16(1):32. doi: 10.1186/s12943-017-0599-6. PubMed |
| Genome Editing Reveals Glioblastoma Addiction to MicroRNA-10b. El Fatimy R, Subramanian S, Uhlmann EJ, Krichevsky AM. Mol Ther. 2017 Feb 1;25(2):368-378. doi: 10.1016/j.ymthe.2016.11.004. PubMed |
Dnmt3a restrains mast cell inflammatory responses.
Leoni C, Montagner S, Rinaldi A, Bertoni F, Polletti S, Balestrieri C, Monticelli S.
Proc Natl Acad Sci U S A. 2017 Feb 6. pii: 201616420. doi: 10.1073/pnas.1616420114.
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Associated Plasmids |
| Epigenetic regulation of HDAC1 SUMOylation as an endogenous neuroprotection against Abeta toxicity in a mouse model of Alzheimer's disease. Tao CC, Hsu WL, Ma YL, Cheng SJ, Lee EH. Cell Death Differ. 2017 Apr;24(4):597-614. doi: 10.1038/cdd.2016.161. Epub 2017 Feb 10. PubMed |
| Diet-induced obesity links to ER positive breast cancer progression via LPA/PKD-1-CD36 signaling-mediated microvascular remodeling. Dong L, Yuan Y, Opansky C, Chen Y, Aguilera-Barrantes I, Wu S, Yuan R, Cao Q, Cheng YC, Sahoo D, Silverstein RL, Ren B. Oncotarget. 2017 Apr 4;8(14):22550-22562. doi: 10.18632/oncotarget.15123. PubMed |
| E3 ubiquitin ligase Pirh2 enhances tumorigenic properties of human non-small cell lung carcinoma cells. Daks A, Petukhov A, Fedorova O, Shuvalov O, Merkulov V, Vasileva E, Antonov A, Barlev NA. Genes Cancer. 2016 Nov;7(11-12):383-393. doi: 10.18632/genesandcancer.123. PubMed |
| Inhibition of serotonin receptor type 1 in acute myeloid leukemia impairs leukemia stem cell functionality: a promising novel therapeutic target. Etxabe A, Lara-Castillo MC, Cornet-Masana JM, Banus-Mulet A, Nomdedeu M, Torrente MA, Pratcorona M, Diaz-Beya M, Esteve J, Risueno RM. Leukemia. 2017 Nov;31(11):2288-2302. doi: 10.1038/leu.2017.52. Epub 2017 Feb 14. PubMed |
| Method for Dual Viral Vector Mediated CRISPR-Cas9 Gene Disruption in Primary Human Endothelial Cells. Gong H, Liu M, Klomp J, Merrill BJ, Rehman J, Malik AB. Sci Rep. 2017 Feb 15;7:42127. doi: 10.1038/srep42127. PubMed |
| Jerantinine A induces tumor-specific cell death through modulation of splicing factor 3b subunit 1 (SF3B1). Chung FF, Tan PF, Raja VJ, Tan BS, Lim KH, Kam TS, Hii LW, Tan SH, See SJ, Tan YF, Wong LZ, Yam WK, Mai CW, Bradshaw TD, Leong CO. Sci Rep. 2017 Feb 15;7:42504. doi: 10.1038/srep42504. PubMed |
| HOXC8 regulates self-renewal, differentiation and transformation of breast cancer stem cells. Shah M, Cardenas R, Wang B, Persson J, Mongan NP, Grabowska A, Allegrucci C. Mol Cancer. 2017 Feb 16;16(1):38. doi: 10.1186/s12943-017-0605-z. PubMed |
| Restriction of Human Cytomegalovirus Replication by ISG15, a Host Effector Regulated by cGAS-STING Double-Stranded-DNA Sensing. Bianco C, Mohr I. J Virol. 2017 Apr 13;91(9). pii: JVI.02483-16. doi: 10.1128/JVI.02483-16. Print 2017 May 1. PubMed |
| Expression level is a key determinant of E2F1-mediated cell fate. Shats I, Deng M, Davidovich A, Zhang C, Kwon JS, Manandhar D, Gordan R, Yao G, You L. Cell Death Differ. 2017 Apr;24(4):626-637. doi: 10.1038/cdd.2017.12. Epub 2017 Feb 17. PubMed |
| The CRISPR/Cas9 system efficiently reverts the tumorigenic ability of BCR/ABL in vitro and in a xenograft model of chronic myeloid leukemia. Garcia-Tunon I, Hernandez-Sanchez M, Ordonez JL, Alonso-Perez V, Alamo-Quijada M, Benito R, Guerrero C, Hernandez-Rivas JM, Sanchez-Martin M. Oncotarget. 2017 Apr 18;8(16):26027-26040. doi: 10.18632/oncotarget.15215. PubMed |
| Mitochondrial damage elicits a TCDD-inducible poly(ADP-ribose) polymerase-mediated antiviral response. Kozaki T, Komano J, Kanbayashi D, Takahama M, Misawa T, Satoh T, Takeuchi O, Kawai T, Shimizu S, Matsuura Y, Akira S, Saitoh T. Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):2681-2686. doi: 10.1073/pnas.1621508114. Epub 2017 Feb 17. PubMed |
| Enhancement of beta-Globin Gene Expression in Thalassemic IVS2-654 Induced Pluripotent Stem Cell-Derived Erythroid Cells by Modified U7 snRNA. Phanthong P, Borwornpinyo S, Kitiyanant N, Jearawiriyapaisarn N, Nuntakarn L, Saetan J, Nualkaew T, Sa-Ngiamsuntorn K, Anurathapan U, Dinnyes A, Kitiyanant Y, Hongeng S. Stem Cells Transl Med. 2017 Apr;6(4):1059-1069. doi: 10.1002/sctm.16-0121. Epub 2017 Feb 18. PubMed |
| MELK expression in ovarian cancer correlates with poor outcome and its inhibition by OTSSP167 abrogates proliferation and viability of ovarian cancer cells. Kohler RS, Kettelhack H, Knipprath-Meszaros AM, Fedier A, Schoetzau A, Jacob F, Heinzelmann-Schwarz V. Gynecol Oncol. 2017 Apr;145(1):159-166. doi: 10.1016/j.ygyno.2017.02.016. Epub 2017 Feb 14. PubMed |
| Critical threshold levels of DNA methyltransferase 1 are required to maintain DNA methylation across the genome in human cancer cells. Cai Y, Tsai HC, Yen RC, Zhang YW, Kong X, Wang W, Xia L, Baylin SB. Genome Res. 2017 Apr;27(4):533-544. doi: 10.1101/gr.208108.116. Epub 2017 Feb 23. PubMed |
| Hyperglycemia-Induced Changes in ZIP7 and ZnT7 Expression Cause Zn2+ Release From the Sarco(endo)plasmic Reticulum and Mediate ER Stress in the Heart. Tuncay E, Bitirim VC, Durak A, Carrat GRJ, Taylor KM, Rutter GA, Turan B. Diabetes. 2017 May;66(5):1346-1358. doi: 10.2337/db16-1099. Epub 2017 Feb 23. PubMed |
| Upregulation of CD147 Promotes Metastasis of Cholangiocarcinoma by Modulating the Epithelial-to-Mesenchymal Transitional Process. Dana P, Kariya R, Vaeteewoottacharn K, Sawanyawisuth K, Seubwai W, Matsuda K, Okada S, Wongkham S. Oncol Res. 2017 Aug 7;25(7):1047-1059. doi: 10.3727/096504016X14813899000565. Epub 2016 Dec 15. PubMed |
| YOD1/TRAF6 association balances p62-dependent IL-1 signaling to NF-kappaB. Schimmack G, Schorpp K, Kutzner K, Gehring T, Brenke JK, Hadian K, Krappmann D. Elife. 2017 Feb 28;6. pii: e22416. doi: 10.7554/eLife.22416. PubMed |
| A Comprehensive TALEN-Based Knockout Library for Generating Human-Induced Pluripotent Stem Cell-Based Models for Cardiovascular Diseases. Karakikes I, Termglinchan V, Cepeda DA, Lee J, Diecke S, Hendel A, Itzhaki I, Ameen M, Shrestha R, Wu H, Ma N, Shao NY, Seeger T, Woo N, Wilson KD, Matsa E, Porteus MH, Sebastiano V, Wu JC. Circ Res. 2017 May 12;120(10):1561-1571. doi: 10.1161/CIRCRESAHA.116.309948. Epub 2017 Feb 28. PubMed |
Rapid and efficient generation of oligodendrocytes from human induced pluripotent stem cells using transcription factors.
Ehrlich M, Mozafari S, Glatza M, Starost L, Velychko S, Hallmann AL, Cui QL, Schambach A, Kim KP, Bachelin C, Marteyn A, Hargus G, Johnson RM, Antel J, Sterneckert J, Zaehres H, Scholer HR, Baron-Van Evercooren A, Kuhlmann T.
Proc Natl Acad Sci U S A. 2017 Mar 14;114(11):E2243-E2252. doi: 10.1073/pnas.1614412114. Epub 2017 Feb 28.
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Associated Plasmids |
| Linking of mPGES-1 and iNOS activates stem-like phenotype in EGFR-driven epithelial tumor cells. Terzuoli E, Finetti F, Costanza F, Giachetti A, Ziche M, Donnini S. Nitric Oxide. 2017 Jun 1;66:17-29. doi: 10.1016/j.niox.2017.02.010. Epub 2017 Mar 1. PubMed |
| Reactive Oxygen Species-Mediated Loss of Synaptic Akt1 Signaling Leads to Deficient Activity-Dependent Protein Translation Early in Alzheimer's Disease. Ahmad F, Singh K, Das D, Gowaikar R, Shaw E, Ramachandran A, Rupanagudi KV, Kommaddi RP, Bennett DA, Ravindranath V. Antioxid Redox Signal. 2017 Apr 12. doi: 10.1089/ars.2016.6860. PubMed |
| Focal Adhesion Kinase as a Potential Target in AML and MDS. Carter BZ, Mak PY, Wang X, Yang H, Garcia-Manero G, Mak DH, Mu H, Ruvolo VR, Qiu Y, Coombes K, Zhang N, Ragon B, Weaver DT, Pachter JA, Kornblau S, Andreeff M. Mol Cancer Ther. 2017 Jun;16(6):1133-1144. doi: 10.1158/1535-7163.MCT-16-0719. Epub 2017 Mar 7. PubMed |
| Integrin-beta4 identifies cancer stem cell-enriched populations of partially mesenchymal carcinoma cells. Bierie B, Pierce SE, Kroeger C, Stover DG, Pattabiraman DR, Thiru P, Liu Donaher J, Reinhardt F, Chaffer CL, Keckesova Z, Weinberg RA. Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):E2337-E2346. doi: 10.1073/pnas.1618298114. Epub 2017 Mar 7. PubMed |
| The Novel Toll-Like Receptor 2 Agonist SUP3 Enhances Antigen Presentation and T Cell Activation by Dendritic Cells. Guo X, Wu N, Shang Y, Liu X, Wu T, Zhou Y, Liu X, Huang J, Liao X, Wu L. Front Immunol. 2017 Feb 21;8:158. doi: 10.3389/fimmu.2017.00158. eCollection 2017. PubMed |
| Reconstituting development of pancreatic intraepithelial neoplasia from primary human pancreas duct cells. Lee J, Snyder ER, Liu Y, Gu X, Wang J, Flowers BM, Kim YJ, Park S, Szot GL, Hruban RH, Longacre TA, Kim SK. Nat Commun. 2017 Mar 8;8:14686. doi: 10.1038/ncomms14686. PubMed |
DUX4-induced dsRNA and MYC mRNA stabilization activate apoptotic pathways in human cell models of facioscapulohumeral dystrophy.
Shadle SC, Zhong JW, Campbell AE, Conerly ML, Jagannathan S, Wong CJ, Morello TD, van der Maarel SM, Tapscott SJ.
PLoS Genet. 2017 Mar 8;13(3):e1006658. doi: 10.1371/journal.pgen.1006658. eCollection 2017 Mar.
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Associated Plasmids |
| PPAR-alpha Activation Mediates Innate Host Defense through Induction of TFEB and Lipid Catabolism. Kim YS, Lee HM, Kim JK, Yang CS, Kim TS, Jung M, Jin HS, Kim S, Jang J, Oh GT, Kim JM, Jo EK. J Immunol. 2017 Apr 15;198(8):3283-3295. doi: 10.4049/jimmunol.1601920. Epub 2017 Mar 8. PubMed |
| GARLH Family Proteins Stabilize GABAA Receptors at Synapses. Yamasaki T, Hoyos-Ramirez E, Martenson JS, Morimoto-Tomita M, Tomita S. Neuron. 2017 Mar 8;93(5):1138-1152.e6. doi: 10.1016/j.neuron.2017.02.023. PubMed |
| CRISPR-Cas9 system-driven site-specific selection pressure on Herpes simplex virus genomes. Li Z, Bi Y, Xiao H, Sun L, Ren Y, Li Y, Chen C, Cun W. Virus Res. 2017 Mar 6. pii: S0168-1702(16)30694-3. doi: 10.1016/j.virusres.2017.03.010. PubMed |
| Depletion of oxaloacetate decarboxylase FAHD1 inhibits mitochondrial electron transport and induces cellular senescence in human endothelial cells. Petit M, Koziel R, Etemad S, Pircher H, Jansen-Durr P. Exp Gerontol. 2017 Jun;92:7-12. doi: 10.1016/j.exger.2017.03.004. Epub 2017 Mar 8. PubMed |
Optogenetic control with a photocleavable protein, PhoCl.
Zhang W, Lohman AW, Zhuravlova Y, Lu X, Wiens MD, Hoi H, Yaganoglu S, Mohr MA, Kitova EN, Klassen JS, Pantazis P, Thompson RJ, Campbell RE.
Nat Methods. 2017 Mar 13. doi: 10.1038/nmeth.4222.
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Associated Plasmids |
| Reduction of Ether-Type Glycerophospholipids, Plasmalogens, by NF-kappaB Signal Leading to Microglial Activation. Hossain MS, Abe Y, Ali F, Youssef M, Honsho M, Fujiki Y, Katafuchi T. J Neurosci. 2017 Apr 12;37(15):4074-4092. doi: 10.1523/JNEUROSCI.3941-15.2017. Epub 2017 Mar 14. PubMed |
| PSMA redirects cell survival signaling from the MAPK to the PI3K-AKT pathways to promote the progression of prostate cancer. Caromile LA, Dortche K, Rahman MM, Grant CL, Stoddard C, Ferrer FA, Shapiro LH. Sci Signal. 2017 Mar 14;10(470). pii: 10/470/eaag3326. doi: 10.1126/scisignal.aag3326. PubMed |
| ORAI2 modulates store-operated calcium entry and T cell-mediated immunity. Vaeth M, Yang J, Yamashita M, Zee I, Eckstein M, Knosp C, Kaufmann U, Karoly Jani P, Lacruz RS, Flockerzi V, Kacskovics I, Prakriya M, Feske S. Nat Commun. 2017 Mar 15;8:14714. doi: 10.1038/ncomms14714. PubMed |
DND1 maintains germline stem cells via recruitment of the CCR4-NOT complex to target mRNAs.
Yamaji M, Jishage M, Meyer C, Suryawanshi H, Der E, Yamaji M, Garzia A, Morozov P, Manickavel S, McFarland HL, Roeder RG, Hafner M, Tuschl T.
Nature. 2017 Mar 23;543(7646):568-572. doi: 10.1038/nature21690. Epub 2017 Mar 15.
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Associated Plasmids |
| Quantifying 3D chemotaxis in microfluidic-based chips with step gradients of collagen hydrogel concentrations. Del Amo C, Borau C, Movilla N, Asin J, Garcia-Aznar JM. Integr Biol (Camb). 2017 Apr 18;9(4):339-349. doi: 10.1039/c7ib00022g. PubMed |
| Tumor Suppressor PTPRJ Is a Target of miR-155 in Colorectal Cancer. Zhang XF, Tu R, Li K, Ye P, Cui X. J Cell Biochem. 2017 Mar 18. doi: 10.1002/jcb.25995. PubMed |
| Silencing of the small GTPase DIRAS3 induces cellular senescence in human white adipose stromal/progenitor cells. Ejaz A, Mattesich M, Zwerschke W. Aging (Albany NY). 2017 Mar 17;9(3):860-879. doi: 10.18632/aging.101197. PubMed |
| Transcription factor NF-kappa B represses ANT1 transcription and leads to mitochondrial dysfunctions. Zhang C, Jiang H, Wang P, Liu H, Sun X. Sci Rep. 2017 Mar 20;7:44708. doi: 10.1038/srep44708. PubMed |
| Combinatorial CRISPR-Cas9 screens for de novo mapping of genetic interactions. Shen JP, Zhao D, Sasik R, Luebeck J, Birmingham A, Bojorquez-Gomez A, Licon K, Klepper K, Pekin D, Beckett AN, Sanchez KS, Thomas A, Kuo CC, Du D, Roguev A, Lewis NE, Chang AN, Kreisberg JF, Krogan N, Qi L, Ideker T, Mali P. Nat Methods. 2017 Jun;14(6):573-576. doi: 10.1038/nmeth.4225. Epub 2017 Mar 20. PubMed |
| Hepatocyte nuclear factor 1alpha downregulates HBV gene expression and replication by activating the NF-kappaB signaling pathway. Lin J, Gu C, Shen Z, Liu Y, Wang W, Tao S, Cui X, Liu J, Xie Y. PLoS One. 2017 Mar 20;12(3):e0174017. doi: 10.1371/journal.pone.0174017. eCollection 2017. PubMed |
| The H3K27 demethylase, Utx, regulates adipogenesis in a differentiation stage-dependent manner. Ota K, Tong KI, Goto K, Tomida S, Komuro A, Wang Z, Nishio K, Okada H. PLoS One. 2017 Mar 20;12(3):e0173713. doi: 10.1371/journal.pone.0173713. eCollection 2017. PubMed |
| Using Protein-Fragment Complementation Assays (PCA) and Peptide Arrays to Study Telomeric Protein-Protein Interactions. Ma W, Lee OH, Kim H, Songyang Z. Methods Mol Biol. 2017;1587:147-160. doi: 10.1007/978-1-4939-6892-3_15. PubMed |
| Bovine trophectoderm cells induced from bovine fibroblasts with induced pluripotent stem cell reprogramming factors. Talbot NC, Sparks WO, Phillips CE, Ealy AD, Powell AM, Caperna TJ, Garrett WM, Donovan DM, Blomberg LA. Mol Reprod Dev. 2017 Jun;84(6):468-485. doi: 10.1002/mrd.22797. Epub 2017 Apr 12. PubMed |
Genome-scale CRISPR-Cas9 knockout and transcriptional activation screening.
Joung J, Konermann S, Gootenberg JS, Abudayyeh OO, Platt RJ, Brigham MD, Sanjana NE, Zhang F.
Nat Protoc. 2017 Apr;12(4):828-863. doi: 10.1038/nprot.2017.016. Epub 2017 Mar 23.
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Associated Plasmids |
| Geometry-dependent functional changes in iPSC-derived cardiomyocytes probed by functional imaging and RNA sequencing. Werley CA, Chien MP, Gaublomme J, Shekhar K, Butty V, Yi BA, Kralj JM, Bloxham W, Boyer LA, Regev A, Cohen AE. PLoS One. 2017 Mar 23;12(3):e0172671. doi: 10.1371/journal.pone.0172671. eCollection 2017. PubMed |
| Requirement of cytosolic phospholipase A2 gamma in lipid droplet formation. Su X, Liu S, Zhang X, Lam SM, Hu X, Zhou Y, Chen J, Wang Y, Wu C, Shui G, Lu M, Pei R, Chen X. Biochim Biophys Acta. 2017 Jul;1862(7):692-705. doi: 10.1016/j.bbalip.2017.03.007. Epub 2017 Mar 21. PubMed |
A DNA-Based T Cell Receptor Reveals a Role for Receptor Clustering in Ligand Discrimination.
Taylor MJ, Husain K, Gartner ZJ, Mayor S, Vale RD.
Cell. 2017 Mar 23;169(1):108-119.e20. doi: 10.1016/j.cell.2017.03.006.
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Associated Plasmids |
| Polo-like kinase 1 expression is suppressed by CCAAT/enhancer-binding protein alpha to mediate colon carcinoma cell differentiation and apoptosis. Dasgupta N, Thakur BK, Ta A, Das S, Banik G, Das S. Biochim Biophys Acta. 2017 Jul;1861(7):1777-1787. doi: 10.1016/j.bbagen.2017.03.015. Epub 2017 Mar 21. PubMed |
NRAS destines tumor cells to the lungs.
Giannou AD, Marazioti A, Kanellakis NI, Giopanou I, Lilis I, Zazara DE, Ntaliarda G, Kati D, Armenis V, Giotopoulou GA, Krontira AC, Lianou M, Agalioti T, Vreka M, Papageorgopoulou M, Fouzas S, Kardamakis D, Psallidas I, Spella M, Stathopoulos GT.
EMBO Mol Med. 2017 May;9(5):672-686. doi: 10.15252/emmm.201606978.
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Associated Plasmids |
| Reporter Systems to Study HTLV-1 Transmission. Gross C, Thoma-Kress AK. Methods Mol Biol. 2017;1582:33-46. doi: 10.1007/978-1-4939-6872-5_3. PubMed |
| Analyzing trapped protein complexes by Virotrap and SFINX. Titeca K, Van Quickelberghe E, Samyn N, De Sutter D, Verhee A, Gevaert K, Tavernier J, Eyckerman S. Nat Protoc. 2017 May;12(5):881-898. doi: 10.1038/nprot.2017.014. Epub 2017 Mar 30. PubMed |
| Sedentary lifestyle related exosomal release of Hotair from gluteal-femoral fat promotes intestinal cell proliferation. Lu X, Bai D, Liu X, Zhou C, Yang G. Sci Rep. 2017 Mar 31;7:45648. doi: 10.1038/srep45648. PubMed |
CRISPR-Cas9 epigenome editing enables high-throughput screening for functional regulatory elements in the human genome.
Klann TS, Black JB, Chellappan M, Safi A, Song L, Hilton IB, Crawford GE, Reddy TE, Gersbach CA.
Nat Biotechnol. 2017 Apr 3. doi: 10.1038/nbt.3853.
PubMed
Associated Plasmids |
| FKBP65-dependent peptidyl-prolyl isomerase activity potentiates the lysyl hydroxylase 2-driven collagen cross-link switch. Chen Y, Terajima M, Banerjee P, Guo H, Liu X, Yu J, Yamauchi M, Kurie JM. Sci Rep. 2017 Apr 5;7:46021. doi: 10.1038/srep46021. PubMed |
| Mutation of the Human Circadian Clock Gene CRY1 in Familial Delayed Sleep Phase Disorder. Patke A, Murphy PJ, Onat OE, Krieger AC, Ozcelik T, Campbell SS, Young MW. Cell. 2017 Apr 6;169(2):203-215.e13. doi: 10.1016/j.cell.2017.03.027. PubMed |
| Pyroptosis and Apoptosis Pathways Engage in Bidirectional Crosstalk in Monocytes and Macrophages. Taabazuing CY, Okondo MC, Bachovchin DA. Cell Chem Biol. 2017 Apr 20;24(4):507-514.e4. doi: 10.1016/j.chembiol.2017.03.009. Epub 2017 Apr 6. PubMed |
| Crystal structure of Zen4 in the apo state reveals a missing conformation of kinesin. Guan R, Zhang L, Su QP, Mickolajczyk KJ, Chen GY, Hancock WO, Sun Y, Zhao Y, Chen Z. Nat Commun. 2017 Apr 10;8:14951. doi: 10.1038/ncomms14951. PubMed |
| Regulation of spindle integrity and mitotic fidelity by BCCIP. Huhn SC, Liu J, Ye C, Lu H, Jiang X, Feng X, Ganesan S, White E, Shen Z. Oncogene. 2017 Aug 17;36(33):4750-4766. doi: 10.1038/onc.2017.92. Epub 2017 Apr 10. PubMed |
| GP73 represses host innate immune response to promote virus replication by facilitating MAVS and TRAF6 degradation. Zhang X, Zhu C, Wang T, Jiang H, Ren Y, Zhang Q, Wu K, Liu F, Liu Y, Wu J. PLoS Pathog. 2017 Apr 10;13(4):e1006321. doi: 10.1371/journal.ppat.1006321. eCollection 2017 Apr. PubMed |
| Generation of an induced pluripotent stem cell line that mimics the disease phenotypes from a patient with Fanconi anemia by conditional complementation. Bharathan SP, Nandy K, Palani D, Janet A NB, Natarajan K, George B, Srivastava A, Velayudhan SR. Stem Cell Res. 2017 Apr;20:54-57. doi: 10.1016/j.scr.2017.02.006. Epub 2017 Feb 22. PubMed |
| In Vivo Enrichment of Diabetogenic T Cells. Thelin MA, Kissler S, Vigneault F, Watters AL, White D, Koshy ST, Vermillion SA, Mooney DJ, Serwold T, Ali OA. Diabetes. 2017 Aug;66(8):2220-2229. doi: 10.2337/db16-0946. Epub 2017 Apr 10. PubMed |
| Induction of functional dopamine neurons from human astrocytes in vitro and mouse astrocytes in a Parkinson's disease model. Rivetti di Val Cervo P, Romanov RA, Spigolon G, Masini D, Martin-Montanez E, Toledo EM, La Manno G, Feyder M, Pifl C, Ng YH, Sanchez SP, Linnarsson S, Wernig M, Harkany T, Fisone G, Arenas E. Nat Biotechnol. 2017 May;35(5):444-452. doi: 10.1038/nbt.3835. Epub 2017 Apr 10. PubMed |
| Hoxa9 and Meis1 Cooperatively Induce Addiction to Syk Signaling by Suppressing miR-146a in Acute Myeloid Leukemia. Mohr S, Doebele C, Comoglio F, Berg T, Beck J, Bohnenberger H, Alexe G, Corso J, Strobel P, Wachter A, Beissbarth T, Schnutgen F, Cremer A, Haetscher N, Gollner S, Rouhi A, Palmqvist L, Rieger MA, Schroeder T, Bonig H, Muller-Tidow C, Kuchenbauer F, Schutz E, Green AR, Urlaub H, Stegmaier K, Humphries RK, Serve H, Oellerich T. Cancer Cell. 2017 Apr 10;31(4):549-562.e11. doi: 10.1016/j.ccell.2017.03.001. PubMed |
| Nucleotide-binding oligomerization domain (NOD) signaling defects and cell death susceptibility cannot be uncoupled in X-linked inhibitor of apoptosis (XIAP)-driven inflammatory disease. Chirieleison SM, Marsh RA, Kumar P, Rathkey JK, Dubyak GR, Abbott DW. J Biol Chem. 2017 Jun 9;292(23):9666-9679. doi: 10.1074/jbc.M117.781500. Epub 2017 Apr 12. PubMed |
| Epithelial-Mesenchymal Micro-niches Govern Stem Cell Lineage Choices. Yang H, Adam RC, Ge Y, Hua ZL, Fuchs E. Cell. 2017 Apr 20;169(3):483-496.e13. doi: 10.1016/j.cell.2017.03.038. Epub 2017 Apr 13. PubMed |
| Synthesis and Degradation of Adenosine 5'-Tetraphosphate by Nicotinamide and Nicotinate Phosphoribosyltransferases. Amici A, Grolla AA, Del Grosso E, Bellini R, Bianchi M, Travelli C, Garavaglia S, Sorci L, Raffaelli N, Ruggieri S, Genazzani AA, Orsomando G. Cell Chem Biol. 2017 May 18;24(5):553-564.e4. doi: 10.1016/j.chembiol.2017.03.010. Epub 2017 Apr 13. PubMed |
| A tiling-deletion-based genetic screen for cis-regulatory element identification in mammalian cells. Diao Y, Fang R, Li B, Meng Z, Yu J, Qiu Y, Lin KC, Huang H, Liu T, Marina RJ, Jung I, Shen Y, Guan KL, Ren B. Nat Methods. 2017 Jun;14(6):629-635. doi: 10.1038/nmeth.4264. Epub 2017 Apr 17. PubMed |
| Effects of altered sialic acid biosynthesis on N-linked glycan branching and cell surface interactions. Pham ND, Pang PC, Krishnamurthy S, Wands AM, Grassi P, Dell A, Haslam SM, Kohler JJ. J Biol Chem. 2017 Jun 9;292(23):9637-9651. doi: 10.1074/jbc.M116.764597. Epub 2017 Apr 19. PubMed |
| A 3D in vitro model of the human breast duct: a method to unravel myoepithelial-luminal interactions in the progression of breast cancer. Carter EP, Gopsill JA, Gomm JJ, Jones JL, Grose RP. Breast Cancer Res. 2017 Apr 21;19(1):50. doi: 10.1186/s13058-017-0843-4. PubMed |
Nitric oxide-regulated proteolysis of human CYP2B6 via the ubiquitin-proteasome system.
Lee CM, Tripathi S, Morgan ET.
Free Radic Biol Med. 2017 Jul;108:478-486. doi: 10.1016/j.freeradbiomed.2017.04.015. Epub 2017 Apr 17.
PubMed
Associated Plasmids |
| Bone-in-culture array as a platform to model early-stage bone metastases and discover anti-metastasis therapies. Wang H, Tian L, Goldstein A, Liu J, Lo HC, Sheng K, Welte T, Wong STC, Gugala Z, Stossi F, Zong C, Li Z, Mancini MA, Zhang XH. Nat Commun. 2017 Apr 21;8:15045. doi: 10.1038/ncomms15045. PubMed |
| TIR-domain-containing adapter-inducing interferon-beta (TRIF) forms filamentous structures, whose pro-apoptotic signalling is terminated by autophagy. Gentle IE, McHenry KT, Weber A, Metz A, Kretz O, Porter D, Hacker G. FEBS J. 2017 Jul;284(13):1987-2003. doi: 10.1111/febs.14091. Epub 2017 May 19. PubMed |
| Age-dependent functional crosstalk between cardiac fibroblasts and cardiomyocytes in a 3D engineered cardiac tissue. Li Y, Asfour H, Bursac N. Acta Biomater. 2017 Jun;55:120-130. doi: 10.1016/j.actbio.2017.04.027. Epub 2017 Apr 25. PubMed |
| PARP1 restricts Epstein Barr Virus lytic reactivation by binding the BZLF1 promoter. Lupey-Green LN, Moquin SA, Martin KA, McDevitt SM, Hulse M, Caruso LB, Pomerantz RT, Miranda JL, Tempera I. Virology. 2017 Jul;507:220-230. doi: 10.1016/j.virol.2017.04.006. Epub 2017 Apr 26. PubMed |
| Gli1+ Mesenchymal Stromal Cells Are a Key Driver of Bone Marrow Fibrosis and an Important Cellular Therapeutic Target. Schneider RK, Mullally A, Dugourd A, Peisker F, Hoogenboezem R, Van Strien PMH, Bindels EM, Heckl D, Busche G, Fleck D, Muller-Newen G, Wongboonsin J, Ventura Ferreira M, Puelles VG, Saez-Rodriguez J, Ebert BL, Humphreys BD, Kramann R. Cell Stem Cell. 2017 Jun 1;20(6):785-800.e8. doi: 10.1016/j.stem.2017.03.008. Epub 2017 Apr 27. PubMed |
| JNK-associated scattered growth of YD-10B oral squamous carcinoma cells while maintaining the epithelial phenotype. Lee G, Kim HM. Biochem Biophys Res Commun. 2017 Jun 10;487(4):862-867. doi: 10.1016/j.bbrc.2017.04.142. Epub 2017 Apr 27. PubMed |
| A Novel Agonist of the TRIF Pathway Induces a Cellular State Refractory to Replication of Zika, Chikungunya, and Dengue Viruses. Pryke KM, Abraham J, Sali TM, Gall BJ, Archer I, Liu A, Bambina S, Baird J, Gough M, Chakhtoura M, Haddad EK, Kirby IT, Nilsen A, Streblow DN, Hirsch AJ, Smith JL, DeFilippis VR. MBio. 2017 May 2;8(3). pii: e00452-17. doi: 10.1128/mBio.00452-17. PubMed |
| Aberrant caveolin-1-mediated Smad signaling and proliferation identified by analysis of adenine 474 deletion mutation (c.474delA) in patient fibroblasts: a new perspective on the mechanism of pulmonary hypertension. Marsboom G, Chen Z, Yuan Y, Zhang Y, Tiruppathi C, Loyd JE, Austin ED, Machado RF, Minshall RD, Rehman J, Malik AB. Mol Biol Cell. 2017 May 1;28(9):1177-1185. doi: 10.1091/mbc.E16-11-0790. PubMed |
| Primary cilia control the maturation of tubular lumen in renal collecting duct epithelium. Ernandez T, Komarynets O, Chassot A, Sougoumarin S, Soulie P, Wang Y, Montesano R, Feraille E. Am J Physiol Cell Physiol. 2017 Jul 1;313(1):C94-C107. doi: 10.1152/ajpcell.00290.2016. Epub 2017 May 3. PubMed |
| Releasing Syntaphilin Removes Stressed Mitochondria from Axons Independent of Mitophagy under Pathophysiological Conditions. Lin MY, Cheng XT, Tammineni P, Xie Y, Zhou B, Cai Q, Sheng ZH. Neuron. 2017 May 3;94(3):595-610.e6. doi: 10.1016/j.neuron.2017.04.004. PubMed |
| The role of ORF3 accessory protein in replication of cell-adapted porcine epidemic diarrhea virus (PEDV). Wongthida P, Liwnaree B, Wanasen N, Narkpuk J, Jongkaewwattana A. Arch Virol. 2017 May 4. doi: 10.1007/s00705-017-3390-5. PubMed |
| CHD1 regulates cell fate determination by activation of differentiation-induced genes. Baumgart SJ, Najafova Z, Hossan T, Xie W, Nagarajan S, Kari V, Ditzel N, Kassem M, Johnsen SA. Nucleic Acids Res. 2017 May 5. doi: 10.1093/nar/gkx377. PubMed |
| Linear ubiquitination of cytosolic Salmonella Typhimurium activates NF-kappaB and restricts bacterial proliferation. van Wijk SJL, Fricke F, Herhaus L, Gupta J, Hotte K, Pampaloni F, Grumati P, Kaulich M, Sou YS, Komatsu M, Greten FR, Fulda S, Heilemann M, Dikic I. Nat Microbiol. 2017 May 8;2:17066. doi: 10.1038/nmicrobiol.2017.66. PubMed |
| Electrophysiological Properties and Viability of Neonatal Rat Ventricular Myocyte Cultures with Inducible ChR2 Expression. Li Q, Ni RR, Hong H, Goh KY, Rossi M, Fast VG, Zhou L. Sci Rep. 2017 May 8;7(1):1531. doi: 10.1038/s41598-017-01723-2. PubMed |
| CHD4 Has Oncogenic Functions in Initiating and Maintaining Epigenetic Suppression of Multiple Tumor Suppressor Genes. Xia L, Huang W, Bellani M, Seidman MM, Wu K, Fan D, Nie Y, Cai Y, Zhang YW, Yu LR, Li H, Zahnow CA, Xie W, Chiu Yen RW, Rassool FV, Baylin SB. Cancer Cell. 2017 May 8;31(5):653-668.e7. doi: 10.1016/j.ccell.2017.04.005. PubMed |
| Cap-binding protein 4EHP effects translation silencing by microRNAs. Chapat C, Jafarnejad SM, Matta-Camacho E, Hesketh GG, Gelbart IA, Attig J, Gkogkas CG, Alain T, Stern-Ginossar N, Fabian MR, Gingras AC, Duchaine TF, Sonenberg N. Proc Natl Acad Sci U S A. 2017 May 23;114(21):5425-5430. doi: 10.1073/pnas.1701488114. Epub 2017 May 9. PubMed |
| Protein Phosphatase 2A (PP2A) Regulates EG5 to Control Mitotic Progression. Liu Y, Zhang Z, Liang H, Zhao X, Liang L, Wang G, Yang J, Jin Y, McNutt MA, Yin Y. Sci Rep. 2017 May 9;7(1):1630. doi: 10.1038/s41598-017-01915-w. PubMed |
| Sensing of HIV-1 Entry Triggers a Type I Interferon Response in Human Primary Macrophages. Decalf J, Desdouits M, Rodrigues V, Gobert FX, Gentili M, Marques-Ladeira S, Chamontin C, Mougel M, Cunha de Alencar B, Benaroch P. J Virol. 2017 Jul 12;91(15). pii: e00147-17. doi: 10.1128/JVI.00147-17. Print 2017 Aug 1. PubMed |
| Deletion of the Vaccinia Virus I2 Protein Interrupts Virion Morphogenesis, Leading to Retention of the Scaffold Protein and Mislocalization of Membrane-Associated Entry Proteins. Hyun SI, Weisberg A, Moss B. J Virol. 2017 Jul 12;91(15). pii: e00558-17. doi: 10.1128/JVI.00558-17. Print 2017 Aug 1. PubMed |
| PHD3 is a transcriptional coactivator of HIF-1alpha in nucleus pulposus cells independent of the PKM2-JMJD5 axis. Schoepflin ZR, Silagi ES, Shapiro IM, Risbud MV. FASEB J. 2017 May 11. pii: fj.201601291R. doi: 10.1096/fj.201601291R. PubMed |
| Integrase-Deficient Lentiviral Vector as an All-in-One Platform for Highly Efficient CRISPR/Cas9-Mediated Gene Editing. Ortinski PI, O'Donovan B, Dong X, Kantor B. Mol Ther Methods Clin Dev. 2017 Apr 19;5:153-164. doi: 10.1016/j.omtm.2017.04.002. eCollection 2017 Jun 16. PubMed |
| Structure based discovery of clomifene as a potent inhibitor of cancer-associated mutant IDH1. Zheng M, Sun W, Gao S, Luan S, Li D, Chen R, Zhang Q, Chen L, Huang J, Li H. Oncotarget. 2017 Jul 4;8(27):44255-44265. doi: 10.18632/oncotarget.17464. PubMed |
| Glucose Can Epigenetically Alter the Gene Expression of Neurotrophic Factors in the Murine Brain Cells. Hossain MS, Oomura Y, Katafuchi T. Mol Neurobiol. 2017 May 13. doi: 10.1007/s12035-017-0578-3. PubMed |
| A clinical drug library screen identifies clobetasol propionate as an NRF2 inhibitor with potential therapeutic efficacy in KEAP1 mutant lung cancer. Choi EJ, Jung BJ, Lee SH, Yoo HS, Shin EA, Ko HJ, Chang S, Kim SY, Jeon SM. Oncogene. 2017 Sep 14;36(37):5285-5295. doi: 10.1038/onc.2017.153. Epub 2017 May 15. PubMed |
| Role of NF-E2 related factor 2 (Nrf2) on chemotherapy resistance in acute myeloid leukemia (AML) and the effect of pharmacological inhibition of Nrf2. Karathedath S, Rajamani BM, Musheer Aalam SM, Abraham A, Varatharajan S, Krishnamurthy P, Mathews V, Velayudhan SR, Balasubramanian P. PLoS One. 2017 May 15;12(5):e0177227. doi: 10.1371/journal.pone.0177227. eCollection 2017. PubMed |
Mutant KRAS promotes malignant pleural effusion formation.
Agalioti T, Giannou AD, Krontira AC, Kanellakis NI, Kati D, Vreka M, Pepe M, Spella M, Lilis I, Zazara DE, Nikolouli E, Spiropoulou N, Papadakis A, Papadia K, Voulgaridis A, Harokopos V, Stamou P, Meiners S, Eickelberg O, Snyder LA, Antimisiaris SG, Kardamakis D, Psallidas I, Marazioti A, Stathopoulos GT.
Nat Commun. 2017 May 16;8:15205. doi: 10.1038/ncomms15205.
PubMed
Associated Plasmids |
| A dual phenotype of MDA-MB-468 cancer cells reveals mutual regulation of tensin3 and adhesion plasticity. Vess A, Blache U, Leitner L, Kurz ARM, Ehrenpfordt A, Sixt M, Posern G. J Cell Sci. 2017 Jul 1;130(13):2172-2184. doi: 10.1242/jcs.200899. Epub 2017 May 17. PubMed |
| E2F1 inhibits circulating cholesterol clearance by regulating Pcsk9 expression in the liver. Lai Q, Giralt A, Le May C, Zhang L, Cariou B, Denechaud PD, Fajas L. JCI Insight. 2017 May 18;2(10). pii: 89729. doi: 10.1172/jci.insight.89729. PubMed |
| Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells. Wei HH, Liu Y, Wang Y, Lu Q, Yang X, Li J, Wang Z. J Vis Exp. 2017 Apr 26;(122). doi: 10.3791/54967. PubMed |
Homology-mediated end joining-based targeted integration using CRISPR/Cas9.
Yao X, Wang X, Hu X, Liu Z, Liu J, Zhou H, Shen X, Wei Y, Huang Z, Ying W, Wang Y, Nie YH, Zhang CC, Li S, Cheng L, Wang Q, Wu Y, Huang P, Sun Q, Shi L, Yang H.
Cell Res. 2017 May 19. doi: 10.1038/cr.2017.76.
PubMed
Associated Plasmids |
| Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function. Sakamaki JI, Wilkinson S, Hahn M, Tasdemir N, O'Prey J, Clark W, Hedley A, Nixon C, Long JS, New M, Van Acker T, Tooze SA, Lowe SW, Dikic I, Ryan KM. Mol Cell. 2017 May 18;66(4):517-532.e9. doi: 10.1016/j.molcel.2017.04.027. PubMed |
| Shedding of host autophagic proteins from the parasitophorous vacuolar membrane of Plasmodium berghei. Agop-Nersesian C, De Niz M, Niklaus L, Prado M, Eickel N, Heussler VT. Sci Rep. 2017 May 19;7(1):2191. doi: 10.1038/s41598-017-02156-7. PubMed |
| The N-terminus of the prion protein is a toxic effector regulated by the C-terminus. Wu B, McDonald AJ, Markham K, Rich CB, McHugh KP, Tatzelt J, Colby DW, Millhauser GL, Harris DA. Elife. 2017 May 20;6. pii: e23473. doi: 10.7554/eLife.23473. PubMed |
| CRISPR/Cas9 - Mediated Precise Targeted Integration In Vivo Using a Double Cut Donor with Short Homology Arms. Yao X, Wang X, Liu J, Hu X, Shi L, Shen X, Ying W, Sun X, Wang X, Huang P, Yang H. EBioMedicine. 2017 Jun;20:19-26. doi: 10.1016/j.ebiom.2017.05.015. Epub 2017 May 11. PubMed |
| A novel isoform of TET1 that lacks a CXXC domain is overexpressed in cancer. Good CR, Madzo J, Patel B, Maegawa S, Engel N, Jelinek J, Issa JJ. Nucleic Acids Res. 2017 May 22. doi: 10.1093/nar/gkx435. PubMed |
| Polylactide- and polycaprolactone-based substrates enhance angiogenic potential of human umbilical cord-derived mesenchymal stem cells in vitro - implications for cardiovascular repair. Sekula M, Domalik-Pyzik P, Morawska-Chochol A, Bobis-Wozowicz S, Karnas E, Noga S, Boruczkowski D, Adamiak M, Madeja Z, Chlopek J, Zuba-Surma EK. Mater Sci Eng C Mater Biol Appl. 2017 Aug 1;77:521-533. doi: 10.1016/j.msec.2017.03.281. Epub 2017 Mar 30. PubMed |
| cGAS is essential for cellular senescence. Yang H, Wang H, Ren J, Chen Q, Chen ZJ. Proc Natl Acad Sci U S A. 2017 Jun 6;114(23):E4612-E4620. doi: 10.1073/pnas.1705499114. Epub 2017 May 22. PubMed |
| Discovery of Stromal Regulatory Networks that Suppress Ras-Sensitized Epithelial Cell Proliferation. Liu H, Dowdle JA, Khurshid S, Sullivan NJ, Bertos N, Rambani K, Mair M, Daniel P, Wheeler E, Tang X, Toth K, Lause M, Harrigan ME, Eiring K, Sullivan C, Sullivan MJ, Chang SW, Srivastava S, Conway JS, Kladney R, McElroy J, Bae S, Lu Y, Tofigh A, Saleh SMI, Fernandez SA, Parvin JD, Coppola V, Macrae ER, Majumder S, Shapiro CL, Yee LD, Ramaswamy B, Hallett M, Ostrowski MC, Park M, Chamberlin HM, Leone G. Dev Cell. 2017 May 22;41(4):392-407.e6. doi: 10.1016/j.devcel.2017.04.024. PubMed |
| The ubiquitin ligase STUB1 regulates stability and activity of RUNX1 and RUNX1-RUNX1T1. Yonezawa T, Takahashi H, Shikata S, Liu X, Tamura M, Asada S, Fukushima T, Fukuyama T, Tanaka Y, Sawasaki T, Kitamura T, Goyama S. J Biol Chem. 2017 Jul 28;292(30):12528-12541. doi: 10.1074/jbc.M117.785675. Epub 2017 May 23. PubMed |
| Extracellular Interactions between Hepatitis C Virus and Secreted Apolipoprotein E. Li Z, Li Y, Bi Y, Zhang H, Yao Y, Li Q, Cun W, Dong S. J Virol. 2017 Jul 12;91(15). pii: e02227-16. doi: 10.1128/JVI.02227-16. Print 2017 Aug 1. PubMed |
| CD146 (MCAM) in human cs-DLK1-/cs-CD34+ adipose stromal/progenitor cells. Horl S, Ejaz A, Ernst S, Mattesich M, Kaiser A, Jenewein B, Zwierzina ME, Hammerle S, Miggitsch C, Mitterberger-Vogt MC, Krautgasser C, Pierer G, Zwerschke W. Stem Cell Res. 2017 Jul;22:1-12. doi: 10.1016/j.scr.2017.05.004. Epub 2017 May 17. PubMed |
| Role of peptidylarginine deiminase 2 (PAD2) in mammary carcinoma cell migration. Horibata S, Rogers KE, Sadegh D, Anguish LJ, McElwee JL, Shah P, Thompson PR, Coonrod SA. BMC Cancer. 2017 May 26;17(1):378. doi: 10.1186/s12885-017-3354-x. PubMed |
| Knockdown of sodium-calcium exchanger 1 induces epithelial-to-mesenchymal transition in kidney epithelial cells. Balasubramaniam SL, Gopalakrishnapillai A, Petrelli NJ, Barwe SP. J Biol Chem. 2017 Jul 7;292(27):11388-11399. doi: 10.1074/jbc.M116.752352. Epub 2017 May 26. PubMed |
| Single-Virus Droplet Microfluidics for High-Throughput Screening of Neutralizing Epitopes on HIV Particles. Chaipan C, Pryszlak A, Dean H, Poignard P, Benes V, Griffiths AD, Merten CA. Cell Chem Biol. 2017 Jun 22;24(6):751-757.e3. doi: 10.1016/j.chembiol.2017.05.009. Epub 2017 May 25. PubMed |
| PI3K class II alpha regulates delta-opioid receptor export from the trans-Golgi network. Shiwarski DJ, Darr M, Telmer CA, Bruchez MP, Puthenveedu MA. Mol Biol Cell. 2017 Aug 1;28(16):2202-2219. doi: 10.1091/mbc.E17-01-0030. Epub 2017 May 31. PubMed |
CRISPR-Cas9-induced t(11;19)/MLL-ENL translocations initiate leukemia in human hematopoietic progenitor cells in vivo.
Reimer J, Knoess S, Labuhn M, Charpentier EM, Gohring G, Schlegelberger B, Klusmann JH, Heckl D.
Haematologica. 2017 Jun 1. pii: haematol.2017.164046. doi: 10.3324/haematol.2017.164046.
PubMed
Associated Plasmids |
| Synchronized HIV assembly by tunable PIP2 changes reveals PIP2 requirement for stable Gag anchoring. Mucksch F, Laketa V, Muller B, Schultz C, Krausslich HG. Elife. 2017 Jun 2;6. pii: e25287. doi: 10.7554/eLife.25287. PubMed |
| The PYRIN domain-only protein POP2 inhibits inflammasome priming and activation. Ratsimandresy RA, Chu LH, Khare S, de Almeida L, Gangopadhyay A, Indramohan M, Misharin AV, Greaves DR, Perlman H, Dorfleutner A, Stehlik C. Nat Commun. 2017 Jun 5;8:15556. doi: 10.1038/ncomms15556. PubMed |
| Effect of tryptase inhibition on joint inflammation: a pharmacological and lentivirus-mediated gene transfer study. Denadai-Souza A, Ribeiro CM, Rolland C, Thouard A, Deraison C, Scavone C, Gonzalez-Dunia D, Vergnolle N, Avellar MCW. Arthritis Res Ther. 2017 Jun 6;19(1):124. doi: 10.1186/s13075-017-1326-9. PubMed |
| Tightly controlled MRTF-A activity regulates epithelial differentiation during formation of mammary acini. Seifert A, Posern G. Breast Cancer Res. 2017 Jun 7;19(1):68. doi: 10.1186/s13058-017-0860-3. PubMed |
| Linaclotide activates guanylate cyclase-C/cGMP/protein kinase-II-dependent trafficking of CFTR in the intestine. Ahsan MK, Tchernychev B, Kessler MM, Solinga RM, Arthur D, Linde CI, Silos-Santiago I, Hannig G, Ameen NA. Physiol Rep. 2017 Jun;5(11). pii: 5/11/e13299. doi: 10.14814/phy2.13299. PubMed |
| The metalloproteinase ADAM8 promotes leukocyte recruitment in vitro and in acute lung inflammation. Dreymueller D, Pruessmeyer J, Schumacher J, Fellendorf S, Hess FM, Seifert A, Babendreyer A, Bartsch JW, Ludwig A. Am J Physiol Lung Cell Mol Physiol. 2017 Jun 8:ajplung.00444.2016. doi: 10.1152/ajplung.00444.2016. PubMed |
| Integrin alpha7 Is a Functional Marker and Potential Therapeutic Target in Glioblastoma. Haas TL, Sciuto MR, Brunetto L, Valvo C, Signore M, Fiori ME, di Martino S, Giannetti S, Morgante L, Boe A, Patrizii M, Warnken U, Schnolzer M, Ciolfi A, Di Stefano C, Biffoni M, Ricci-Vitiani L, Pallini R, De Maria R. Cell Stem Cell. 2017 Jul 6;21(1):35-50.e9. doi: 10.1016/j.stem.2017.04.009. Epub 2017 Jun 9. PubMed |
Construction and Screening of a Lentiviral Secretome Library.
Liu T, Jia P, Ma H, Reed SA, Luo X, Larman HB, Schultz PG.
Cell Chem Biol. 2017 Jun 22;24(6):767-771.e3. doi: 10.1016/j.chembiol.2017.05.017. Epub 2017 Jun 9.
PubMed
Associated Plasmids |
| Antigen Presentation by Individually Transferred HLA Class I Genes in HLA-A, HLA-B, HLA-C Null Human Cell Line Generated Using the Multiplex CRISPR-Cas9 System. Hong CH, Sohn HJ, Lee HJ, Cho HI, Kim TG. J Immunother. 2017 Jul/Aug;40(6):201-210. doi: 10.1097/CJI.0000000000000176. PubMed |
| Ohmyungsamycins promote antimicrobial responses through autophagy activation via AMP-activated protein kinase pathway. Kim TS, Shin YH, Lee HM, Kim JK, Choe JH, Jang JC, Um S, Jin HS, Komatsu M, Cha GH, Chae HJ, Oh DC, Jo EK. Sci Rep. 2017 Jun 13;7(1):3431. doi: 10.1038/s41598-017-03477-3. PubMed |
| Reduction of infection by inhibiting mTOR pathway is associated with reversed repression of type I interferon by porcine reproductive and respiratory syndrome virus. Liu Q, Miller LC, Blecha F, Sang Y. J Gen Virol. 2017 Jun;98(6):1316-1328. doi: 10.1099/jgv.0.000802. Epub 2017 Jun 14. PubMed |
| Defects in autophagosome-lysosome fusion underlie Vici syndrome, a neurodevelopmental disorder with multisystem involvement. Hori I, Otomo T, Nakashima M, Miya F, Negishi Y, Shiraishi H, Nonoda Y, Magara S, Tohyama J, Okamoto N, Kumagai T, Shimoda K, Yukitake Y, Kajikawa D, Morio T, Hattori A, Nakagawa M, Ando N, Nishino I, Kato M, Tsunoda T, Saitsu H, Kanemura Y, Yamasaki M, Kosaki K, Matsumoto N, Yoshimori T, Saitoh S. Sci Rep. 2017 Jun 14;7(1):3552. doi: 10.1038/s41598-017-02840-8. PubMed |
| BAIAP3, a C2 domain-containing Munc13 protein, controls the fate of dense-core vesicles in neuroendocrine cells. Zhang X, Jiang S, Mitok KA, Li L, Attie AD, Martin TFJ. J Cell Biol. 2017 Jul 3;216(7):2151-2166. doi: 10.1083/jcb.201702099. Epub 2017 Jun 16. PubMed |
| Autophagy impairment mediated by S-nitrosation of ATG4B leads to neurotoxicity in response to hyperglycemia. Li Y, Zhang Y, Wang L, Wang P, Xue Y, Li X, Qiao X, Zhang X, Xu T, Liu G, Li P, Chen C. Autophagy. 2017 Jul 3;13(7):1145-1160. doi: 10.1080/15548627.2017.1320467. PubMed |
| Generation of Induced Pluripotent Stem Cells in Defined Three-Dimensional Hydrogels. Caiazzo M, Tabata Y, Lutolf M. Methods Mol Biol. 2017;1612:65-78. doi: 10.1007/978-1-4939-7021-6_5. PubMed |
| Sam68 Allows Selective Targeting of Human Cancer Stem Cells. Benoit YD, Mitchell RR, Risueno RM, Orlando L, Tanasijevic B, Boyd AL, Aslostovar L, Salci KR, Shapovalova Z, Russell J, Eguchi M, Golubeva D, Graham M, Xenocostas A, Trus MR, Foley R, Leber B, Collins TJ, Bhatia M. Cell Chem Biol. 2017 Jul 20;24(7):833-844.e9. doi: 10.1016/j.chembiol.2017.05.026. Epub 2017 Jun 22. PubMed |
| Targeting MCL-1 sensitizes human esophageal squamous cell carcinoma cells to cisplatin-induced apoptosis. Yu X, Li W, Xia Z, Xie L, Ma X, Liang Q, Liu L, Wang J, Zhou X, Yang Y, Liu H. BMC Cancer. 2017 Jun 28;17(1):449. doi: 10.1186/s12885-017-3442-y. PubMed |
| TTC19 Plays a Husbandry Role on UQCRFS1 Turnover in the Biogenesis of Mitochondrial Respiratory Complex III. Bottani E, Cerutti R, Harbour ME, Ravaglia S, Dogan SA, Giordano C, Fearnley IM, D'Amati G, Viscomi C, Fernandez-Vizarra E, Zeviani M. Mol Cell. 2017 Jul 6;67(1):96-105.e4. doi: 10.1016/j.molcel.2017.06.001. Epub 2017 Jun 29. PubMed |
| Lack of evidence for involvement of TonEBP and hyperosmotic stimulus in induction of autophagy in the nucleus pulposus. Liu C, Choi H, Johnson ZI, Tian J, Shapiro IM, Risbud MV. Sci Rep. 2017 Jul 3;7(1):4543. doi: 10.1038/s41598-017-04876-2. PubMed |
| In-Cell Western Assays to Evaluate Hantaan Virus Replication as a Novel Approach to Screen Antiviral Molecules and Detect Neutralizing Antibody Titers. Ma HW, Ye W, Chen HS, Nie TJ, Cheng LF, Zhang L, Han PJ, Wu XA, Xu ZK, Lei YF, Zhang FL. Front Cell Infect Microbiol. 2017 Jun 20;7:269. doi: 10.3389/fcimb.2017.00269. eCollection 2017. PubMed |
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| ATF4-Induced Metabolic Reprograming Is a Synthetic Vulnerability of the p62-Deficient Tumor Stroma. Linares JF, Cordes T, Duran A, Reina-Campos M, Valencia T, Ahn CS, Castilla EA, Moscat J, Metallo CM, Diaz-Meco MT. Cell Metab. 2017 Dec 5;26(6):817-829.e6. doi: 10.1016/j.cmet.2017.09.001. Epub 2017 Oct 5. PubMed |
| Cell Cycle-Dependent Tumor Engraftment and Migration Are Enabled by Aurora-A. Chu TLH, Connell M, Zhou L, He Z, Won J, Chen H, Rahavi SMR, Mohan P, Nemirovsky O, Fotovati A, Pujana MA, Reid GSD, Nielsen TO, Pante N, Maxwell CA. Mol Cancer Res. 2018 Jan;16(1):16-31. doi: 10.1158/1541-7786.MCR-17-0417. Epub 2017 Oct 9. PubMed |
| ANO9/TMEM16J promotes tumourigenesis via EGFR and is a novel therapeutic target for pancreatic cancer. Jun I, Park HS, Piao H, Han JW, An MJ, Yun BG, Zhang X, Cha YH, Shin YK, Yook JI, Jung J, Gee HY, Park JS, Yoon DS, Jeung HC, Lee MG. Br J Cancer. 2017 Dec 5;117(12):1798-1809. doi: 10.1038/bjc.2017.355. Epub 2017 Oct 12. PubMed |
| BRCA1 or CDK12 loss sensitizes cells to CHK1 inhibitors. Paculova H, Kramara J, Simeckova S, Fedr R, Soucek K, Hylse O, Paruch K, Svoboda M, Mistrik M, Kohoutek J. Tumour Biol. 2017 Oct;39(10):1010428317727479. doi: 10.1177/1010428317727479. PubMed |
| MCT1 and MCT4 Expression and Lactate Flux Activity Increase During White and Brown Adipogenesis and Impact Adipocyte Metabolism. Petersen C, Nielsen MD, Andersen ES, Basse AL, Isidor MS, Markussen LK, Viuff BM, Lambert IH, Hansen JB, Pedersen SF. Sci Rep. 2017 Oct 12;7(1):13101. doi: 10.1038/s41598-017-13298-z. PubMed |
| Modulation of the NF-kappaB signaling pathway by the HIV-2 envelope glycoprotein and its incomplete BST-2 antagonism. Dufrasne FE, Lucchetti M, Martin A, Andre E, Dessilly G, Kabamba B, Goubau P, Ruelle J. Virology. 2018 Jan 1;513:11-16. doi: 10.1016/j.virol.2017.09.024. Epub 2017 Oct 11. PubMed |
| Merkel cell polyomavirus recruits MYCL to the EP400 complex to promote oncogenesis. Cheng J, Park DE, Berrios C, White EA, Arora R, Yoon R, Branigan T, Xiao T, Westerling T, Federation A, Zeid R, Strober B, Swanson SK, Florens L, Bradner JE, Brown M, Howley PM, Padi M, Washburn MP, DeCaprio JA. PLoS Pathog. 2017 Oct 13;13(10):e1006668. doi: 10.1371/journal.ppat.1006668. eCollection 2017 Oct. PubMed |
ANGPTL8 promotes the ability of ANGPTL3 to bind and inhibit lipoprotein lipase.
Chi X, Britt EC, Shows HW, Hjelmaas AJ, Shetty SK, Cushing EM, Li W, Dou A, Zhang R, Davies BSJ.
Mol Metab. 2017 Oct;6(10):1137-1149. doi: 10.1016/j.molmet.2017.06.014. Epub 2017 Jun 29.
PubMed
Associated Plasmids |
| Widespread Post-transcriptional Attenuation of Genomic Copy-Number Variation in Cancer. Goncalves E, Fragoulis A, Garcia-Alonso L, Cramer T, Saez-Rodriguez J, Beltrao P. Cell Syst. 2017 Oct 25;5(4):386-398.e4. doi: 10.1016/j.cels.2017.08.013. Epub 2017 Oct 11. PubMed |
| Genome-Nuclear Lamina Interactions Regulate Cardiac Stem Cell Lineage Restriction. Poleshko A, Shah PP, Gupta M, Babu A, Morley MP, Manderfield LJ, Ifkovits JL, Calderon D, Aghajanian H, Sierra-Pagan JE, Sun Z, Wang Q, Li L, Dubois NC, Morrisey EE, Lazar MA, Smith CL, Epstein JA, Jain R. Cell. 2017 Oct 19;171(3):573-587.e14. doi: 10.1016/j.cell.2017.09.018. Epub 2017 Oct 12. PubMed |
CRISPR/Cas9-mediated gene knockout is insensitive to target copy number but is dependent on guide RNA potency and Cas9/sgRNA threshold expression level.
Yuen G, Khan FJ, Gao S, Stommel JM, Batchelor E, Wu X, Luo J.
Nucleic Acids Res. 2017 Nov 16;45(20):12039-12053. doi: 10.1093/nar/gkx843.
PubMed
Associated Plasmids |
| TRIM29 promotes DNA virus infections by inhibiting innate immune response. Xing J, Zhang A, Zhang H, Wang J, Li XC, Zeng MS, Zhang Z. Nat Commun. 2017 Oct 16;8(1):945. doi: 10.1038/s41467-017-00101-w. PubMed |
| Gene delivery of hypoxia-inducible VEGF targeting collagen effectively improves cardiac function after myocardial infarction. Xia JB, Wu HY, Lai BL, Zheng L, Zhou DC, Chang ZS, Mao CZ, Liu GH, Park KS, Zhao H, Kim SK, Song GH, Cai DQ, Qi XF. Sci Rep. 2017 Oct 16;7(1):13273. doi: 10.1038/s41598-017-13547-1. PubMed |
| Toll-Like Receptor 8 Is a Major Sensor of Group B Streptococcus But Not Escherichia coli in Human Primary Monocytes and Macrophages. Ehrnstrom B, Beckwith KS, Yurchenko M, Moen SH, Kojen JF, Lentini G, Teti G, Damas JK, Espevik T, Stenvik J. Front Immunol. 2017 Oct 3;8:1243. doi: 10.3389/fimmu.2017.01243. eCollection 2017. PubMed |
| MANF Promotes Differentiation and Migration of Neural Progenitor Cells with Potential Neural Regenerative Effects in Stroke. Tseng KY, Anttila JE, Khodosevich K, Tuominen RK, Lindahl M, Domanskyi A, Airavaara M. Mol Ther. 2018 Jan 3;26(1):238-255. doi: 10.1016/j.ymthe.2017.09.019. Epub 2017 Sep 21. PubMed |
| Assembly of the WHIP-TRIM14-PPP6C Mitochondrial Complex Promotes RIG-I-Mediated Antiviral Signaling. Tan P, He L, Cui J, Qian C, Cao X, Lin M, Zhu Q, Li Y, Xing C, Yu X, Wang HY, Wang RF. Mol Cell. 2017 Oct 19;68(2):293-307.e5. doi: 10.1016/j.molcel.2017.09.035. PubMed |
| CpG oligodeoxynucleotide preconditioning improves cardiac function after myocardial infarction via modulation of energy metabolism and angiogenesis. Zhou DC, Su YH, Jiang FQ, Xia JB, Wu HY, Chang ZS, Peng WT, Song GH, Park KS, Kim SK, Cai DQ, Zheng L, Qi XF. J Cell Physiol. 2018 May;233(5):4245-4257. doi: 10.1002/jcp.26243. Epub 2017 Nov 24. PubMed |
| TGF-beta receptor I/II trafficking and signaling at primary cilia are inhibited by ceramide to attenuate cell migration and tumor metastasis. Gencer S, Oleinik N, Kim J, Panneer Selvam S, De Palma R, Dany M, Nganga R, Thomas RJ, Senkal CE, Howe PH, Ogretmen B. Sci Signal. 2017 Oct 24;10(502). pii: 10/502/eaam7464. doi: 10.1126/scisignal.aam7464. PubMed |
| UTX-guided neural crest function underlies craniofacial features of Kabuki syndrome. Shpargel KB, Starmer J, Wang C, Ge K, Magnuson T. Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):E9046-E9055. doi: 10.1073/pnas.1705011114. Epub 2017 Oct 9. PubMed |
Intercellular mRNA trafficking via membrane nanotube-like extensions in mammalian cells.
Haimovich G, Ecker CM, Dunagin MC, Eggan E, Raj A, Gerst JE, Singer RH.
Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):E9873-E9882. doi: 10.1073/pnas.1706365114. Epub 2017 Oct 24.
PubMed
Associated Plasmids |
| Design, Assembly, Production, and Transfection of Synthetic Modified mRNA. Oh S, Kessler JA. Methods. 2018 Jan 15;133:29-43. doi: 10.1016/j.ymeth.2017.10.008. Epub 2017 Nov 7. PubMed |
| Class III phosphatidylinositol-3-OH kinase controls epithelial integrity through endosomal LKB1 regulation. O'Farrell F, Lobert VH, Sneeggen M, Jain A, Katheder NS, Wenzel EM, Schultz SW, Tan KW, Brech A, Stenmark H, Rusten TE. Nat Cell Biol. 2017 Dec;19(12):1412-1423. doi: 10.1038/ncb3631. Epub 2017 Oct 30. PubMed |
| APC downregulated 1 inhibits breast cancer cell invasion by inhibiting the canonical WNT signaling pathway. Cho SG. Oncol Lett. 2017 Oct;14(4):4845-4852. doi: 10.3892/ol.2017.6801. Epub 2017 Aug 23. PubMed |
| A vimentin binding small molecule leads to mitotic disruption in mesenchymal cancers. Bollong MJ, Pietila M, Pearson AD, Sarkar TR, Ahmad I, Soundararajan R, Lyssiotis CA, Mani SA, Schultz PG, Lairson LL. Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):E9903-E9912. doi: 10.1073/pnas.1716009114. Epub 2017 Oct 30. PubMed |
| StUbEx PLUS-A Modified Stable Tagged Ubiquitin Exchange System for Peptide Level Purification and In-Depth Mapping of Ubiquitination Sites. Akimov V, Olsen LCB, Hansen SVF, Barrio-Hernandez I, Puglia M, Jensen SS, Solov'yov IA, Kratchmarova I, Blagoev B. J Proteome Res. 2018 Jan 5;17(1):296-304. doi: 10.1021/acs.jproteome.7b00566. Epub 2017 Nov 1. PubMed |
| Involvement of Zizimin2/3 in the age-related defect of peritoneal B-1a cells as a source of anti-bacterial IgM. Sakamoto A, Matsuda T, Kawaguchi K, Takaoka A, Maruyama M. Int Immunol. 2017 Nov 1;29(9):431-438. doi: 10.1093/intimm/dxx054. PubMed |
| TGF-beta-Induced Quiescence Mediates Chemoresistance of Tumor-Propagating Cells in Squamous Cell Carcinoma. Brown JA, Yonekubo Y, Hanson N, Sastre-Perona A, Basin A, Rytlewski JA, Dolgalev I, Meehan S, Tsirigos A, Beronja S, Schober M. Cell Stem Cell. 2017 Nov 2;21(5):650-664.e8. doi: 10.1016/j.stem.2017.10.001. PubMed |
| In Vivo Survival of Human Endometrial Mesenchymal Stem Cells Transplanted Under the Kidney Capsule of Immunocompromised Mice. Gurung S, Deane JA, Darzi S, Werkmeister JA, Gargett CE. Stem Cells Dev. 2018 Jan 1;27(1):35-43. doi: 10.1089/scd.2017.0177. Epub 2017 Dec 5. PubMed |
| Nuclear TRIM25 Specifically Targets Influenza Virus Ribonucleoproteins to Block the Onset of RNA Chain Elongation. Meyerson NR, Zhou L, Guo YR, Zhao C, Tao YJ, Krug RM, Sawyer SL. Cell Host Microbe. 2017 Nov 8;22(5):627-638.e7. doi: 10.1016/j.chom.2017.10.003. Epub 2017 Nov 5. PubMed |
| STK38L kinase ablation promotes loss of cell viability in a subset of KRAS-dependent pancreatic cancer cell lines. Grant TJ, Mehta AK, Gupta A, Sharif AAD, Arora KS, Deshpande V, Ting DT, Bardeesy N, Ganem NJ, Hergovich A, Singh A. Oncotarget. 2017 Sep 11;8(45):78556-78572. doi: 10.18632/oncotarget.20833. eCollection 2017 Oct 3. PubMed |
| Multitarget inhibition by four tandem shRNAs embedded in homo or heteromiRNA backbones. Du X, Cai Y, Xi W, Zhang R, Jia L, Yang A, Zhao J, Yan B. Mol Med Rep. 2018 Jan;17(1):307-314. doi: 10.3892/mmr.2017.7854. Epub 2017 Oct 20. PubMed |
| Maternal embryonic leucine zipper kinase is a novel target for proliferation-associated high-risk myeloma. Bolomsky A, Heusschen R, Schlangen K, Stangelberger K, Muller J, Schreiner W, Zojer N, Caers J, Ludwig H. Haematologica. 2018 Feb;103(2):325-335. doi: 10.3324/haematol.2017.172973. Epub 2017 Nov 9. PubMed |
A Map of Human Mitochondrial Protein Interactions Linked to Neurodegeneration Reveals New Mechanisms of Redox Homeostasis and NF-kappaB Signaling.
Malty RH, Aoki H, Kumar A, Phanse S, Amin S, Zhang Q, Minic Z, Goebels F, Musso G, Wu Z, Abou-Tok H, Meyer M, Deineko V, Kassir S, Sidhu V, Jessulat M, Scott NE, Xiong X, Vlasblom J, Prasad B, Foster LJ, Alberio T, Garavaglia B, Yu H, Bader GD, Nakamura K, Parkinson J, Babu M.
Cell Syst. 2017 Nov 7. pii: S2405-4712(17)30447-7. doi: 10.1016/j.cels.2017.10.010.
PubMed
Associated Plasmids |
| Deguelin, an Aurora B Kinase Inhibitor, Exhibits Potent Anti-Tumor Effect in Human Esophageal Squamous Cell Carcinoma. Yu X, Liang Q, Liu W, Zhou L, Li W, Liu H. EBioMedicine. 2017 Dec;26:100-111. doi: 10.1016/j.ebiom.2017.10.030. Epub 2017 Nov 3. PubMed |
| Nonimmune cells equipped with T-cell-receptor-like signaling for cancer cell ablation. Kojima R, Scheller L, Fussenegger M. Nat Chem Biol. 2018 Jan;14(1):42-49. doi: 10.1038/nchembio.2498. Epub 2017 Nov 13. PubMed |
| Loss of E-cadherin provides tolerance to centrosome amplification in epithelial cancer cells. Rhys AD, Monteiro P, Smith C, Vaghela M, Arnandis T, Kato T, Leitinger B, Sahai E, McAinsh A, Charras G, Godinho SA. J Cell Biol. 2018 Jan 2;217(1):195-209. doi: 10.1083/jcb.201704102. Epub 2017 Nov 13. PubMed |
| Chemokine Signaling Facilitates Early-Stage Breast Cancer Survival and Invasion through Fibroblast-Dependent Mechanisms. Brummer G, Acevedo DS, Hu Q, Portsche M, Fang WB, Yao M, Zinda B, Myers M, Alvarez N, Fields P, Hong Y, Behbod F, Cheng N. Mol Cancer Res. 2018 Feb;16(2):296-308. doi: 10.1158/1541-7786.MCR-17-0308. Epub 2017 Nov 13. PubMed |
| C/EBPbeta mediates RNA polymerase III-driven transcription of oncomiR-138 in malignant gliomas. Di Pascale F, Nama S, Muhuri M, Quah S, Ismail HM, Chan XHD, Sundaram GM, Ramalingam R, Burke B, Sampath P. Nucleic Acids Res. 2018 Jan 9;46(1):336-349. doi: 10.1093/nar/gkx1105. PubMed |
| JNK Promotes Epithelial Cell Anoikis by Transcriptional and Post-translational Regulation of BH3-Only Proteins. Girnius N, Davis RJ. Cell Rep. 2017 Nov 14;21(7):1910-1921. doi: 10.1016/j.celrep.2017.10.067. PubMed |
| Salt bridges gate alpha-catenin activation at intercellular junctions. Barrick S, Li J, Kong X, Ray A, Tajkhorshid E, Leckband D. Mol Biol Cell. 2018 Jan 15;29(2):111-122. doi: 10.1091/mbc.E17-03-0168. Epub 2017 Nov 15. PubMed |
| BCAT1 restricts alphaKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation. Raffel S, Falcone M, Kneisel N, Hansson J, Wang W, Lutz C, Bullinger L, Poschet G, Nonnenmacher Y, Barnert A, Bahr C, Zeisberger P, Przybylla A, Sohn M, Tonjes M, Erez A, Adler L, Jensen P, Scholl C, Frohling S, Cocciardi S, Wuchter P, Thiede C, Florcken A, Westermann J, Ehninger G, Lichter P, Hiller K, Hell R, Herrmann C, Ho AD, Krijgsveld J, Radlwimmer B, Trumpp A. Nature. 2017 Nov 16;551(7680):384-388. doi: 10.1038/nature24294. Epub 2017 Nov 8. PubMed |
| Cre-dependent Cas9-expressing pigs enable efficient in vivo genome editing. Wang K, Jin Q, Ruan D, Yang Y, Liu Q, Wu H, Zhou Z, Ouyang Z, Liu Z, Zhao Y, Zhao B, Zhang Q, Peng J, Lai C, Fan N, Liang Y, Lan T, Li N, Wang X, Wang X, Fan Y, Doevendans PA, Sluijter JPG, Liu P, Li X, Lai L. Genome Res. 2017 Dec;27(12):2061-2071. doi: 10.1101/gr.222521.117. Epub 2017 Nov 16. PubMed |
| Harnessing BET Inhibitor Sensitivity Reveals AMIGO2 as a Melanoma Survival Gene. Fontanals-Cirera B, Hasson D, Vardabasso C, Di Micco R, Agrawal P, Chowdhury A, Gantz M, de Pablos-Aragoneses A, Morgenstern A, Wu P, Filipescu D, Valle-Garcia D, Darvishian F, Roe JS, Davies MA, Vakoc CR, Hernando E, Bernstein E. Mol Cell. 2017 Nov 16;68(4):731-744.e9. doi: 10.1016/j.molcel.2017.11.004. PubMed |
A Method for the Acute and Rapid Degradation of Endogenous Proteins.
Clift D, McEwan WA, Labzin LI, Konieczny V, Mogessie B, James LC, Schuh M.
Cell. 2017 Nov 13. pii: S0092-8674(17)31255-2. doi: 10.1016/j.cell.2017.10.033.
PubMed
Associated Plasmids |
| Glutaminase inhibition in multiple myeloma induces apoptosis via MYC degradation. Effenberger M, Bommert KS, Kunz V, Kruk J, Leich E, Rudelius M, Bargou R, Bommert K. Oncotarget. 2017 Aug 24;8(49):85858-85867. doi: 10.18632/oncotarget.20691. eCollection 2017 Oct 17. PubMed |
| Display of the Albumin-Binding Domain in the Envelope Improves Lentiviral Vector Bioavailability. Garaulet G, Lazcano JJ, Alarcon H, de Frutos S, Martinez-Torrecuadrada JL, Rodriguez A. Hum Gene Ther Methods. 2017 Dec;28(6):340-351. doi: 10.1089/hgtb.2017.057. PubMed |
| 3D collagen architecture induces a conserved migratory and transcriptional response linked to vasculogenic mimicry. Velez DO, Tsui B, Goshia T, Chute CL, Han A, Carter H, Fraley SI. Nat Commun. 2017 Nov 21;8(1):1651. doi: 10.1038/s41467-017-01556-7. PubMed |
| Nicotinic Acetylcholine Receptor Subtype Alpha-9 Mediates Triple-Negative Breast Cancers Based on a Spontaneous Pulmonary Metastasis Mouse Model. Huang LC, Lin CL, Qiu JZ, Lin CY, Hsu KW, Tam KW, Lee JY, Yang JM, Lee CH. Front Cell Neurosci. 2017 Nov 3;11:336. doi: 10.3389/fncel.2017.00336. eCollection 2017. PubMed |
| Regulatory T Cell Migration Is Dependent on Glucokinase-Mediated Glycolysis. Kishore M, Cheung KCP, Fu H, Bonacina F, Wang G, Coe D, Ward EJ, Colamatteo A, Jangani M, Baragetti A, Matarese G, Smith DM, Haas R, Mauro C, Wraith DC, Okkenhaug K, Catapano AL, De Rosa V, Norata GD, Marelli-Berg FM. Immunity. 2017 Nov 21;47(5):875-889.e10. doi: 10.1016/j.immuni.2017.10.017. PubMed |
| Foot-and-mouth disease virus capsid protein VP2 activates the cellular EIF2S1-ATF4 pathway and induces autophagy via HSPB1. Sun P, Zhang S, Qin X, Chang X, Cui X, Li H, Zhang S, Gao H, Wang P, Zhang Z, Luo J, Li Z. Autophagy. 2018;14(2):336-346. doi: 10.1080/15548627.2017.1405187. Epub 2018 Jan 29. PubMed |
| Vacuolar protein sorting 13C is a novel lipid droplet protein that inhibits lipolysis in brown adipocytes. Ramseyer VD, Kimler VA, Granneman JG. Mol Metab. 2018 Jan;7:57-70. doi: 10.1016/j.molmet.2017.10.014. Epub 2017 Nov 12. PubMed |
| Migration against the direction of flow is LFA-1-dependent in human hematopoietic stem and progenitor cells. Buffone A Jr, Anderson NR, Hammer DA. J Cell Sci. 2018 Jan 10;131(1). pii: jcs.205575. doi: 10.1242/jcs.205575. PubMed |
| The ATPase activity of Asna1/TRC40 is required for pancreatic progenitor cell survival. Norlin S, Parekh V, Edlund H. Development. 2018 Jan 3;145(1). pii: dev.154468. doi: 10.1242/dev.154468. PubMed |
| Smad4 SUMOylation is essential for memory formation through upregulation of the skeletal myopathy gene TPM2. Hsu WL, Ma YL, Liu YC, Lee EHY. BMC Biol. 2017 Nov 28;15(1):112. doi: 10.1186/s12915-017-0452-9. PubMed |
| Cardiopatch platform enables maturation and scale-up of human pluripotent stem cell-derived engineered heart tissues. Shadrin IY, Allen BW, Qian Y, Jackman CP, Carlson AL, Juhas ME, Bursac N. Nat Commun. 2017 Nov 28;8(1):1825. doi: 10.1038/s41467-017-01946-x. PubMed |
| p53 promotes AKT and SP1-dependent metabolism through the pentose phosphate pathway that inhibits apoptosis in response to Nutlin-3a. Duan L, Perez RE, Chen L, Blatter LA, Maki CG. J Mol Cell Biol. 2018 Aug 1;10(4):331-340. doi: 10.1093/jmcb/mjx051. PubMed |
| Crosstalk between developing vasculature and optogenetically engineered skeletal muscle improves muscle contraction and angiogenesis. Osaki T, Sivathanu V, Kamm RD. Biomaterials. 2018 Feb;156:65-76. doi: 10.1016/j.biomaterials.2017.11.041. Epub 2017 Nov 25. PubMed |
| Spindle associated membrane protein 1 (Samp1) is required for the differentiation of muscle cells. Jafferali MH, Figueroa RA, Hasan M, Hallberg E. Sci Rep. 2017 Nov 30;7(1):16655. doi: 10.1038/s41598-017-16746-y. PubMed |
| Protein-lysine methyltransferases G9a and GLP1 promote responses to DNA damage. Ginjala V, Rodriguez-Colon L, Ganguly B, Gangidi P, Gallina P, Al-Hraishawi H, Kulkarni A, Tang J, Gheeya J, Simhadri S, Yao M, Xia B, Ganesan S. Sci Rep. 2017 Nov 30;7(1):16613. doi: 10.1038/s41598-017-16480-5. PubMed |
| The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages. Evavold CL, Ruan J, Tan Y, Xia S, Wu H, Kagan JC. Immunity. 2018 Jan 16;48(1):35-44.e6. doi: 10.1016/j.immuni.2017.11.013. Epub 2017 Nov 28. PubMed |
| Slower Dynamics and Aged Mitochondria in Sporadic Alzheimer's Disease. Martin-Maestro P, Gargini R, Garcia E, Perry G, Avila J, Garcia-Escudero V. Oxid Med Cell Longev. 2017;2017:9302761. doi: 10.1155/2017/9302761. Epub 2017 Oct 19. PubMed |
| A population of innate myelolymphoblastoid effector cell expanded by inactivation of mTOR complex 1 in mice. Tang F, Zhang P, Ye P, Lazarski CA, Wu Q, Bergin IL, Bender TP, Hall MN, Cui Y, Zhang L, Jiang T, Liu Y, Zheng P. Elife. 2017 Dec 5;6. pii: 32497. doi: 10.7554/eLife.32497. PubMed |
| Inhibition of ID1-BMPR2 Intrinsic Signaling Sensitizes Glioma Stem Cells to Differentiation Therapy. Jin X, Jin X, Kim LJY, Dixit D, Jeon HY, Kim EJ, Kim JK, Lee SY, Yin J, Rich JN, Kim H. Clin Cancer Res. 2018 Jan 15;24(2):383-394. doi: 10.1158/1078-0432.CCR-17-1529. Epub 2017 Dec 5. PubMed |
| Comprehensive Analysis of Cytomegalovirus pp65 Antigen-Specific CD8(+) T Cell Responses According to Human Leukocyte Antigen Class I Allotypes and Intraindividual Dominance. Hyun SJ, Sohn HJ, Lee HJ, Lee SD, Kim S, Sohn DH, Hong CH, Choi H, Cho HI, Kim TG. Front Immunol. 2017 Nov 21;8:1591. doi: 10.3389/fimmu.2017.01591. eCollection 2017. PubMed |
| Wnt/beta-catenin Signaling Pathway Regulates Specific lncRNAs That Impact Dermal Fibroblasts and Skin Fibrosis. Mullin NK, Mallipeddi NV, Hamburg-Shields E, Ibarra B, Khalil AM, Atit RP. Front Genet. 2017 Nov 21;8:183. doi: 10.3389/fgene.2017.00183. eCollection 2017. PubMed |
| Chemical hypoxia-induced integrated stress response activation in oligodendrocytes is mediated by the transcription factor nuclear factor (erythroid-derived 2)-like 2 (NRF2). Teske N, Liessem A, Fischbach F, Clarner T, Beyer C, Wruck C, Fragoulis A, Tauber SC, Victor M, Kipp M. J Neurochem. 2018 Feb;144(3):285-301. doi: 10.1111/jnc.14270. Epub 2018 Jan 5. PubMed |
| LDB2 inhibits proliferation and migration in liver cancer cells by abrogating HEY1 expression. Yu H, Jia R, Zhao L, Song S, Gu J, Zhang H. Oncotarget. 2017 Oct 10;8(55):94440-94449. doi: 10.18632/oncotarget.21772. eCollection 2017 Nov 7. PubMed |
| Manufacture of Third-Generation Lentivirus for Preclinical Use, with Process Development Considerations for Translation to Good Manufacturing Practice. Gandara C, Affleck V, Stoll EA. Hum Gene Ther Methods. 2018 Feb;29(1):1-15. doi: 10.1089/hgtb.2017.098. Epub 2018 Jan 24. PubMed |
| Tetraspanin CD63 Bridges Autophagic and Endosomal Processes To Regulate Exosomal Secretion and Intracellular Signaling of Epstein-Barr Virus LMP1 Hurwitz SN, Cheerathodi MR, Nkosi D, York SB, Meckes DG Jr. J Virol. 2018 Feb 12;92(5). pii: JVI.01969-17. doi: 10.1128/JVI.01969-17. Print 2018 Mar 1. PubMed |
| Requirement of Treg-intrinsic CTLA4/PKCeta signaling pathway for suppressing tumor immunity. Pedros C, Canonigo-Balancio AJ, Kong KF, Altman A. JCI Insight. 2017 Dec 7;2(23). pii: 95692. doi: 10.1172/jci.insight.95692. PubMed |
| Cytoplasmic Linker Protein CLIP170 Negatively Regulates TLR4 Signaling by Targeting the TLR Adaptor Protein TIRAP. Jakka P, Bhargavi B, Namani S, Murugan S, Splitter G, Radhakrishnan G. J Immunol. 2018 Jan 15;200(2):704-714. doi: 10.4049/jimmunol.1601559. Epub 2017 Dec 8. PubMed |
| Next-Generation Sequencing of Genome-Wide CRISPR Screens. Yau EH, Rana TM. Methods Mol Biol. 2018;1712:203-216. doi: 10.1007/978-1-4939-7514-3_13. PubMed |
YY1 Is a Structural Regulator of Enhancer-Promoter Loops.
Weintraub AS, Li CH, Zamudio AV, Sigova AA, Hannett NM, Day DS, Abraham BJ, Cohen MA, Nabet B, Buckley DL, Guo YE, Hnisz D, Jaenisch R, Bradner JE, Gray NS, Young RA.
Cell. 2017 Dec 14;171(7):1573-1588.e28. doi: 10.1016/j.cell.2017.11.008. Epub 2017 Dec 7.
PubMed
Associated Plasmids |
| Lysyl oxidase-like 3 is required for melanoma cell survival by maintaining genomic stability. Santamaria PG, Floristan A, Fontanals-Cirera B, Vazquez-Naharro A, Santos V, Morales S, Yuste L, Peinado H, Garcia-Gomez A, Portillo F, Hernando E, Cano A. Cell Death Differ. 2017 Dec 11. pii: 10.1038/s41418-017-0030-2. doi: 10.1038/s41418-017-0030-2. PubMed |
| Synthetic Lethality of Combined Bcl-2 Inhibition and p53 Activation in AML: Mechanisms and Superior Antileukemic Efficacy. Pan R, Ruvolo V, Mu H, Leverson JD, Nichols G, Reed JC, Konopleva M, Andreeff M. Cancer Cell. 2017 Dec 11;32(6):748-760.e6. doi: 10.1016/j.ccell.2017.11.003. PubMed |
| Probing the requirement for CD38 in retinoic acid-induced HL-60 cell differentiation with a small molecule dimerizer and genetic knockout. MacDonald RJ, Shrimp JH, Jiang H, Zhang L, Lin H, Yen A. Sci Rep. 2017 Dec 12;7(1):17406. doi: 10.1038/s41598-017-17720-4. PubMed |
| Interaction of porcine reproductive and respiratory syndrome virus proteins with SUMO-conjugating enzyme reveals the SUMOylation of nucleocapsid protein. Wang C, Zeng N, Liu S, Miao Q, Zhou L, Ge X, Han J, Guo X, Yang H. PLoS One. 2017 Dec 13;12(12):e0189191. doi: 10.1371/journal.pone.0189191. eCollection 2017. PubMed |
| Primary Ovarian Insufficiency and Azoospermia in Carriers of a Homozygous PSMC3IP Stop Gain Mutation. Al-Agha AE, Ahmed IA, Nuebel E, Moriwaki M, Moore B, Peacock KA, Mosbruger T, Neklason DW, Jorde LB, Yandell M, Welt CK. J Clin Endocrinol Metab. 2018 Feb 1;103(2):555-563. doi: 10.1210/jc.2017-01966. PubMed |
| Dual repression of endocytic players by ESCC microRNAs and the Polycomb complex regulates mouse embryonic stem cell pluripotency. Mote RD, Mahajan G, Padmanabhan A, Ambati R, Subramanyam D. Sci Rep. 2017 Dec 14;7(1):17572. doi: 10.1038/s41598-017-17828-7. PubMed |
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| Oncogenic RAS-Induced Perinuclear Signaling Complexes Requiring KSR1 Regulate Signal Transmission to Downstream Targets. Basu SK, Lee S, Salotti J, Basu S, Sakchaisri K, Xiao Z, Walia V, Westlake CJ, Morrison DK, Johnson PF. Cancer Res. 2018 Feb 15;78(4):891-908. doi: 10.1158/0008-5472.CAN-17-2353. Epub 2017 Dec 19. PubMed |
| Protective role of FKBP51 in calcium entry-induced endothelial barrier disruption. Hamilton CL, Kadeba PI, Vasauskas AA, Solodushko V, McClinton AK, Alexeyev M, Scammell JG, Cioffi DL. Pulm Circ. 2018 Jan-Mar;8(1):2045893217749987. doi: 10.1177/2045893217749987. Epub 2017 Dec 20. PubMed |
| ABR, a novel inducer of transcription factor C/EBPalpha, contributes to myeloid differentiation and is a favorable prognostic factor in acute myeloid leukemia. Namasu CY, Katzerke C, Brauer-Hartmann D, Wurm AA, Gerloff D, Hartmann JU, Schwind S, Muller-Tidow C, Hilger N, Fricke S, Christopeit M, Niederwieser D, Behre G. Oncotarget. 2017 Oct 26;8(61):103626-103639. doi: 10.18632/oncotarget.22093. eCollection 2017 Nov 28. PubMed |
| Emerging Alphaviruses Are Sensitive to Cellular States Induced by a Novel Small-Molecule Agonist of the STING Pathway. Gall B, Pryke K, Abraham J, Mizuno N, Botto S, Sali TM, Broeckel R, Haese N, Nilsen A, Placzek A, Morrison T, Heise M, Streblow D, DeFilippis V. J Virol. 2018 Feb 26;92(6). pii: JVI.01913-17. doi: 10.1128/JVI.01913-17. Print 2018 Mar 15. PubMed |
| Genomic and Proteomic Resolution of Heterochromatin and Its Restriction of Alternate Fate Genes. Becker JS, McCarthy RL, Sidoli S, Donahue G, Kaeding KE, He Z, Lin S, Garcia BA, Zaret KS. Mol Cell. 2017 Dec 21;68(6):1023-1037.e15. doi: 10.1016/j.molcel.2017.11.030. PubMed |
| AP-1 Transcription Factors and the BAF Complex Mediate Signal-Dependent Enhancer Selection. Vierbuchen T, Ling E, Cowley CJ, Couch CH, Wang X, Harmin DA, Roberts CWM, Greenberg ME. Mol Cell. 2017 Dec 21;68(6):1067-1082.e12. doi: 10.1016/j.molcel.2017.11.026. PubMed |
| TRAIL induces apoptosis but not necroptosis in colorectal and pancreatic cancer cells preferentially via the TRAIL-R2/DR5 receptor. Nahacka Z, Svadlenka J, Peterka M, Ksandrova M, Benesova S, Neuzil J, Andera L. Biochim Biophys Acta. 2018 Mar;1865(3):522-531. doi: 10.1016/j.bbamcr.2017.12.006. Epub 2017 Dec 24. PubMed |
| Reversible dual inhibitor against G9a and DNMT1 improves human iPSC derivation enhancing MET and facilitating transcription factor engagement to the genome. Rodriguez-Madoz JR, San Jose-Eneriz E, Rabal O, Zapata-Linares N, Miranda E, Rodriguez S, Porciuncula A, Vilas-Zornoza A, Garate L, Segura V, Guruceaga E, Agirre X, Oyarzabal J, Prosper F. PLoS One. 2017 Dec 27;12(12):e0190275. doi: 10.1371/journal.pone.0190275. eCollection 2017. PubMed |
| A Targeted RNAi Screen Identifies Endocytic Trafficking Factors That Control GLP-1 Receptor Signaling in Pancreatic beta-Cells. Buenaventura T, Kanda N, Douzenis PC, Jones B, Bloom SR, Chabosseau P, Correa IR Jr., Bosco D, Piemonti L, Marchetti P, Johnson PR, Shapiro AMJ, Rutter GA, Tomas A. Diabetes. 2018 Mar;67(3):385-399. doi: 10.2337/db17-0639. Epub 2017 Dec 28. PubMed |
| The role of host DNA ligases in hepadnavirus covalently closed circular DNA formation. Long Q, Yan R, Hu J, Cai D, Mitra B, Kim ES, Marchetti A, Zhang H, Wang S, Liu Y, Huang A, Guo H. PLoS Pathog. 2017 Dec 29;13(12):e1006784. doi: 10.1371/journal.ppat.1006784. eCollection 2017 Dec. PubMed |
| The p38 Mitogen-Activated Protein Kinase Critically Regulates Human Keratinocyte Inflammasome Activation. Fenini G, Grossi S, Gehrke S, Beer HD, Satoh TK, Contassot E, French LE. J Invest Dermatol. 2018 Jun;138(6):1380-1390. doi: 10.1016/j.jid.2017.10.037. Epub 2017 Dec 26. PubMed |
| CRISPR Screens Uncover Genes that Regulate Target Cell Sensitivity to the Morphogen Sonic Hedgehog. Pusapati GV, Kong JH, Patel BB, Krishnan A, Sagner A, Kinnebrew M, Briscoe J, Aravind L, Rohatgi R. Dev Cell. 2018 Jan 8;44(1):113-129.e8. doi: 10.1016/j.devcel.2017.12.003. Epub 2017 Dec 28. PubMed |
| Neurocan, an extracellular chondroitin sulfate proteoglycan, stimulates neuroblastoma cells to promote malignant phenotypes. Su Z, Kishida S, Tsubota S, Sakamoto K, Cao D, Kiyonari S, Ohira M, Kamijo T, Narita A, Xu Y, Takahashi Y, Kadomatsu K. Oncotarget. 2017 Nov 15;8(63):106296-106310. doi: 10.18632/oncotarget.22435. eCollection 2017 Dec 5. PubMed |
| Combined venetoclax and alvocidib in acute myeloid leukemia. Bogenberger J, Whatcott C, Hansen N, Delman D, Shi CX, Kim W, Haws H, Soh K, Lee YS, Peterson P, Siddiqui-Jain A, Weitman S, Stewart K, Bearss D, Mesa R, Warner S, Tibes R. Oncotarget. 2017 Nov 3;8(63):107206-107222. doi: 10.18632/oncotarget.22284. eCollection 2017 Dec 5. PubMed |
| Ultrawidefield microscope for high-speed fluorescence imaging and targeted optogenetic stimulation. Werley CA, Chien MP, Cohen AE. Biomed Opt Express. 2017 Nov 29;8(12):5794-5813. doi: 10.1364/BOE.8.005794. eCollection 2017 Dec 1. PubMed |
| A Role for Myosin Va in Human Cytomegalovirus Nuclear Egress. Wilkie AR, Sharma M, Pesola JM, Ericsson M, Fernandez R, Coen DM. J Virol. 2018 Feb 26;92(6). pii: JVI.01849-17. doi: 10.1128/JVI.01849-17. Print 2018 Mar 15. PubMed |
| Colonoscopy-based colorectal cancer modeling in mice with CRISPR-Cas9 genome editing and organoid transplantation. Roper J, Tammela T, Akkad A, Almeqdadi M, Santos SB, Jacks T, Yilmaz OH. Nat Protoc. 2018 Feb;13(2):217-234. doi: 10.1038/nprot.2017.136. Epub 2018 Jan 4. PubMed |
| Importin alpha1 is required for nuclear import of herpes simplex virus proteins and capsid assembly in fibroblasts and neurons. Dohner K, Ramos-Nascimento A, Bialy D, Anderson F, Hickford-Martinez A, Rother F, Koithan T, Rudolph K, Buch A, Prank U, Binz A, Hugel S, Lebbink RJ, Hoeben RC, Hartmann E, Bader M, Bauerfeind R, Sodeik B. PLoS Pathog. 2018 Jan 5;14(1):e1006823. doi: 10.1371/journal.ppat.1006823. eCollection 2018 Jan. PubMed |
| Tousled-like kinase 1 is a negative regulator of core transcription factors in murine embryonic stem cells. Lee J, Kim MS, Park SH, Jang YK. Sci Rep. 2018 Jan 10;8(1):334. doi: 10.1038/s41598-017-18628-9. PubMed |
| The interactome of EBV LMP1 evaluated by proximity-based BioID approach. Rider MA, Cheerathodi MR, Hurwitz SN, Nkosi D, Howell LA, Tremblay DC, Liu X, Zhu F, Meckes DG Jr. Virology. 2018 Mar;516:55-70. doi: 10.1016/j.virol.2017.12.033. Epub 2018 Jan 9. PubMed |
| The HIV-1 accessory proteins Nef and Vpu downregulate total and cell surface CD28 in CD4(+) T cells. Pawlak EN, Dirk BS, Jacob RA, Johnson AL, Dikeakos JD. Retrovirology. 2018 Jan 12;15(1):6. doi: 10.1186/s12977-018-0388-3. PubMed |
| Frequent overexpression of AMAP1, an Arf6 effector in cell invasion, is characteristic of the MMTV-PyMT rather than the MMTV-Neu human breast cancer model. Otsuka Y, Oikawa T, Yoshino H, Hashimoto S, Handa H, Yamamoto H, Hashimoto A, Sabe H. Cell Commun Signal. 2018 Jan 5;16(1):1. doi: 10.1186/s12964-017-0212-z. PubMed |
| Foxo-dependent Par-4 Upregulation Prevents Long-term Survival of Residual Cells Following PI3K-Akt Inhibition. Damrauer JS, Phelps SN, Amuchastegui K, Lupo R, Mabe NW, Walens A, Kroger BR, Alvarez JV. Mol Cancer Res. 2018 Apr;16(4):599-609. doi: 10.1158/1541-7786.MCR-17-0492. Epub 2018 Jan 12. PubMed |
| High STAP1 expression in DUX4-rearranged cases is not suitable as therapeutic target in pediatric B-cell precursor acute lymphoblastic leukemia. Steeghs EMP, Bakker M, Hoogkamer AQ, Boer JM, Hartman QJ, Stalpers F, Escherich G, de Haas V, de Groot-Kruseman HA, Pieters R, den Boer ML. Sci Rep. 2018 Jan 12;8(1):693. doi: 10.1038/s41598-017-17704-4. PubMed |
Dual gene activation and knockout screen reveals directional dependencies in genetic networks.
Boettcher M, Tian R, Blau JA, Markegard E, Wagner RT, Wu D, Mo X, Biton A, Zaitlen N, Fu H, McCormick F, Kampmann M, McManus MT.
Nat Biotechnol. 2018 Jan 15. pii: nbt.4062. doi: 10.1038/nbt.4062.
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In vivo simultaneous transcriptional activation of multiple genes in the brain using CRISPR-dCas9-activator transgenic mice.
Zhou H, Liu J, Zhou C, Gao N, Rao Z, Li H, Hu X, Li C, Yao X, Shen X, Sun Y, Wei Y, Liu F, Ying W, Zhang J, Tang C, Zhang X, Xu H, Shi L, Cheng L, Huang P, Yang H.
Nat Neurosci. 2018 Jan 15. pii: 10.1038/s41593-017-0060-6. doi: 10.1038/s41593-017-0060-6.
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| Temporal Layering of Signaling Effectors Drives Chromatin Remodeling during Hair Follicle Stem Cell Lineage Progression. Adam RC, Yang H, Ge Y, Lien WH, Wang P, Zhao Y, Polak L, Levorse J, Baksh SC, Zheng D, Fuchs E. Cell Stem Cell. 2018 Mar 1;22(3):398-413.e7. doi: 10.1016/j.stem.2017.12.004. Epub 2018 Jan 11. PubMed |
| Human caspase-4 detects tetra-acylated LPS and cytosolic Francisella and functions differently from murine caspase-11. Lagrange B, Benaoudia S, Wallet P, Magnotti F, Provost A, Michal F, Martin A, Di Lorenzo F, Py BF, Molinaro A, Henry T. Nat Commun. 2018 Jan 16;9(1):242. doi: 10.1038/s41467-017-02682-y. PubMed |
| Human Herpesvirus 8 Interferon Regulatory Factors 1 and 3 Mediate Replication and Latency Activities via Interactions with USP7 Deubiquitinase. Xiang Q, Ju H, Li Q, Mei SC, Chen D, Choi YB, Nicholas J. J Virol. 2018 Mar 14;92(7). pii: JVI.02003-17. doi: 10.1128/JVI.02003-17. Print 2018 Apr 1. PubMed |
| The protective role of DOT1L in UV-induced melanomagenesis. Zhu B, Chen S, Wang H, Yin C, Han C, Peng C, Liu Z, Wan L, Zhang X, Zhang J, Lian CG, Ma P, Xu ZX, Prince S, Wang T, Gao X, Shi Y, Liu D, Liu M, Wei W, Wei Z, Pan J, Wang Y, Xuan Z, Hess J, Hayward NK, Goding CR, Chen X, Zhou J, Cui R. Nat Commun. 2018 Jan 17;9(1):259. doi: 10.1038/s41467-017-02687-7. PubMed |
| Loss of functional BAP1 augments sensitivity to TRAIL in cancer cells. Kolluri KK, Alifrangis C, Kumar N, Ishii Y, Price S, Michaut M, Williams S, Barthorpe S, Lightfoot H, Busacca S, Sharkey A, Yuan Z, Sage EK, Vallath S, Le Quesne J, Tice DA, Alrifai D, von Karstedt S, Montinaro A, Guppy N, Waller DA, Nakas A, Good R, Holmes A, Walczak H, Fennell DA, Garnett M, Iorio F, Wessels L, McDermott U, Janes SM. Elife. 2018 Jan 18;7. pii: 30224. doi: 10.7554/eLife.30224. PubMed |
| The RIG-I-like receptor LGP2 inhibits Dicer-dependent processing of long double-stranded RNA and blocks RNA interference in mammalian cells. van der Veen AG, Maillard PV, Schmidt JM, Lee SA, Deddouche-Grass S, Borg A, Kjaer S, Snijders AP, Reis E Sousa C. EMBO J. 2018 Feb 15;37(4). pii: embj.201797479. doi: 10.15252/embj.201797479. Epub 2018 Jan 19. PubMed |
| Unique properties of TCR-activated p38 are necessary for NFAT-dependent T-cell activation. Alam MS, Gaida MM, Debnath S, Tagad HD, Miller Jenkins LM, Appella E, Rahman MJ, Ashwell JD. PLoS Biol. 2018 Jan 22;16(1):e2004111. doi: 10.1371/journal.pbio.2004111. eCollection 2018 Jan. PubMed |
| Interferon regulatory factor 8 regulates caspase-1 expression to facilitate Epstein-Barr virus reactivation in response to B cell receptor stimulation and chemical induction. Lv DW, Zhang K, Li R. PLoS Pathog. 2018 Jan 22;14(1):e1006868. doi: 10.1371/journal.ppat.1006868. eCollection 2018 Jan. PubMed |
| CRISPR-Based Chromatin Remodeling of the Endogenous Oct4 or Sox2 Locus Enables Reprogramming to Pluripotency. Liu P, Chen M, Liu Y, Qi LS, Ding S. Cell Stem Cell. 2018 Feb 1;22(2):252-261.e4. doi: 10.1016/j.stem.2017.12.001. Epub 2018 Jan 18. PubMed |
| Nucleoplasmic lamins define growth-regulating functions of lamina-associated polypeptide 2alpha in progeria cells. Vidak S, Georgiou K, Fichtinger P, Naetar N, Dechat T, Foisner R. J Cell Sci. 2018 Feb 8;131(3). pii: jcs.208462. doi: 10.1242/jcs.208462. PubMed |
| HNRNPH1 is required for rhabdomyosarcoma cell growth and survival. Li Y, Bakke J, Finkelstein D, Zeng H, Wu J, Chen T. Oncogenesis. 2018 Jan 24;7(1):9. doi: 10.1038/s41389-017-0024-4. PubMed |
| Human Papillomavirus 16 E7 Stabilizes APOBEC3A Protein by Inhibiting Cullin 2-Dependent Protein Degradation. Westrich JA, Warren CJ, Klausner MJ, Guo K, Liu CW, Santiago ML, Pyeon D. J Virol. 2018 Mar 14;92(7). pii: JVI.01318-17. doi: 10.1128/JVI.01318-17. Print 2018 Apr 1. PubMed |
| Rab18 promotes lipid droplet (LD) growth by tethering the ER to LDs through SNARE and NRZ interactions. Xu D, Li Y, Wu L, Li Y, Zhao D, Yu J, Huang T, Ferguson C, Parton RG, Yang H, Li P. J Cell Biol. 2018 Mar 5;217(3):975-995. doi: 10.1083/jcb.201704184. Epub 2018 Jan 24. PubMed |
| Ex vivo Trophoblast-specific Genetic Manipulation Using Lentiviral Delivery. Chakraborty D, Muto M, Soares MJ. Bio Protoc. 2017 Dec 20;7(24):e2652. doi: 10.21769/BioProtoc.2652. PubMed |
| Necessity of p53-binding to the CDH1 locus for its expression defines two epithelial cell types differing in their integrity. Oikawa T, Otsuka Y, Onodera Y, Horikawa M, Handa H, Hashimoto S, Suzuki Y, Sabe H. Sci Rep. 2018 Jan 25;8(1):1595. doi: 10.1038/s41598-018-20043-7. PubMed |
| Third-Generation Human Epidermal Growth Factor Receptor 2 Chimeric Antigen Receptor Expression on Human T Cells Improves with Two-Signal Activation. Dalal AR, Homsy S, Balkhi MY. Hum Gene Ther. 2018 Aug;29(8):845-852. doi: 10.1089/hum.2017.244. Epub 2018 Mar 20. PubMed |
| ERAD-dependent control of the Wnt secretory factor Evi. Glaeser K, Urban M, Fenech E, Voloshanenko O, Kranz D, Lari F, Christianson JC, Boutros M. EMBO J. 2018 Feb 15;37(4). pii: embj.201797311. doi: 10.15252/embj.201797311. Epub 2018 Jan 29. PubMed |
| Estrogen receptor alpha protects pancreatic beta-cells from apoptosis by preserving mitochondrial function and suppressing endoplasmic reticulum stress. Zhou Z, Ribas V, Rajbhandari P, Drew BG, Moore TM, Fluitt AH, Reddish BR, Whitney KA, Georgia S, Vergnes L, Reue K, Liesa M, Shirihai O, van der Bliek AM, Chi NW, Mahata SK, Tiano JP, Hewitt SC, Tontonoz P, Korach KS, Mauvais-Jarvis F, Hevener AL. J Biol Chem. 2018 Mar 30;293(13):4735-4751. doi: 10.1074/jbc.M117.805069. Epub 2018 Jan 29. PubMed |
| Dynamic evolution of regulatory element ensembles in primate CD4(+) T cells. Danko CG, Choate LA, Marks BA, Rice EJ, Wang Z, Chu T, Martins AL, Dukler N, Coonrod SA, Tait Wojno ED, Lis JT, Kraus WL, Siepel A. Nat Ecol Evol. 2018 Mar;2(3):537-548. doi: 10.1038/s41559-017-0447-5. Epub 2018 Jan 29. PubMed |
| Enhancer invasion shapes MYCN-dependent transcriptional amplification in neuroblastoma. Zeid R, Lawlor MA, Poon E, Reyes JM, Fulciniti M, Lopez MA, Scott TG, Nabet B, Erb MA, Winter GE, Jacobson Z, Polaski DR, Karlin KL, Hirsch RA, Munshi NP, Westbrook TF, Chesler L, Lin CY, Bradner JE. Nat Genet. 2018 Apr;50(4):515-523. doi: 10.1038/s41588-018-0044-9. Epub 2018 Jan 29. PubMed |
| Human ex vivo prostate tissue model system identifies ING3 as an oncoprotein. McClurg UL, Nabbi A, Ricordel C, Korolchuk S, McCracken S, Heer R, Wilson L, Butler LM, Irving-Hooper BK, Pedeux R, Robson CN, Riabowol KT, Binda O. Br J Cancer. 2018 Mar 6;118(5):713-726. doi: 10.1038/bjc.2017.447. Epub 2018 Jan 30. PubMed |
| Phosphatidylinositol-(4, 5)-bisphosphate regulates calcium gating of small-conductance cation channel TMEM16F. Ye W, Han TW, Nassar LM, Zubia M, Jan YN, Jan LY. Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):E1667-E1674. doi: 10.1073/pnas.1718728115. Epub 2018 Jan 30. PubMed |
| CD209a Synergizes with Dectin-2 and Mincle to Drive Severe Th17 Cell-Mediated Schistosome Egg-Induced Immunopathology. Kalantari P, Morales Y, Miller EA, Jaramillo LD, Ponichtera HE, Wuethrich MA, Cheong C, Seminario MC, Russo JM, Bunnell SC, Stadecker MJ. Cell Rep. 2018 Jan 30;22(5):1288-1300. doi: 10.1016/j.celrep.2018.01.001. PubMed |
| ATP12A promotes mucus dysfunction during Type 2 airway inflammation. Lennox AT, Coburn SL, Leech JA, Heidrich EM, Kleyman TR, Wenzel SE, Pilewski JM, Corcoran TE, Myerburg MM. Sci Rep. 2018 Feb 1;8(1):2109. doi: 10.1038/s41598-018-20444-8. PubMed |
| The Application of Non-Invasive Apoptosis Detection Sensor (NIADS) on Histone Deacetylation Inhibitor (HDACi)-Induced Breast Cancer Cell Death. Hsu KW, Huang CY, Tam KW, Lin CY, Huang LC, Lin CL, Hsieh WS, Chi WM, Chang YJ, Wei PL, Chen ST, Lee CH. Int J Mol Sci. 2018 Feb 2;19(2). pii: ijms19020452. doi: 10.3390/ijms19020452. PubMed |
| Inhibition of Dpp8/9 Activates the Nlrp1b Inflammasome. Okondo MC, Rao SD, Taabazuing CY, Chui AJ, Poplawski SE, Johnson DC, Bachovchin DA. Cell Chem Biol. 2018 Mar 15;25(3):262-267.e5. doi: 10.1016/j.chembiol.2017.12.013. Epub 2018 Jan 27. PubMed |
| Tuning microtubule dynamics to enhance cancer therapy by modulating FER-mediated CRMP2 phosphorylation. Zheng Y, Sethi R, Mangala LS, Taylor C, Goldsmith J, Wang M, Masuda K, Karaminejadranjbar M, Mannion D, Miranda F, Herrero-Gonzalez S, Hellner K, Chen F, Alsaadi A, Albukhari A, Fotso DC, Yau C, Jiang D, Pradeep S, Rodriguez-Aguayo C, Lopez-Berestein G, Knapp S, Gray NS, Campo L, Myers KA, Dhar S, Ferguson D, Bast RC Jr, Sood AK, von Delft F, Ahmed AA. Nat Commun. 2018 Feb 2;9(1):476. doi: 10.1038/s41467-017-02811-7. PubMed |
| Losmapimod Overcomes Gefitinib Resistance in Non-small Cell Lung Cancer by Preventing Tetraploidization. Yeung YT, Yin S, Lu B, Fan S, Yang R, Bai R, Zhang C, Bode AM, Liu K, Dong Z. EBioMedicine. 2018 Feb;28:51-61. doi: 10.1016/j.ebiom.2018.01.017. Epub 2018 Feb 2. PubMed |
| Antiviral and anti-inflammatory activity of budesonide against human rhinovirus infection mediated via autophagy activation. Kim SR, Song JH, Ahn JH, Lee GS, Ahn H, Yoon SI, Kang SG, Kim PH, Jeon SM, Choi EJ, Shin S, Cha Y, Cho S, Kim DE, Chang SY, Ko HJ. Antiviral Res. 2018 Mar;151:87-96. doi: 10.1016/j.antiviral.2018.01.012. Epub 2018 Feb 3. PubMed |
| MAX to MYCN intracellular ratio drives the aggressive phenotype and clinical outcome of high risk neuroblastoma. Ferrucci F, Ciaccio R, Monticelli S, Pigini P, di Giacomo S, Purgato S, Erriquez D, Bernardoni R, Norris M, Haber M, Milazzo G, Perini G. Biochim Biophys Acta Gene Regul Mech. 2018 Mar;1861(3):235-245. doi: 10.1016/j.bbagrm.2018.01.007. Epub 2018 Feb 3. PubMed |
| Therapeutic Potential of Lentivirus-Mediated Glucagon-Like Peptide-1 Gene Therapy for Diabetes. Tasyurek HM, Altunbas HA, Balci MK, Griffith TS, Sanlioglu S. Hum Gene Ther. 2018 Jul;29(7):802-815. doi: 10.1089/hum.2017.180. Epub 2018 Mar 20. PubMed |
| Translational control of ERK signaling through miRNA/4EHP-directed silencing. Jafarnejad SM, Chapat C, Matta-Camacho E, Gelbart IA, Hesketh GG, Arguello M, Garzia A, Kim SH, Attig J, Shapiro M, Morita M, Khoutorsky A, Alain T, Gkogkas CG, Stern-Ginossar N, Tuschl T, Gingras AC, Duchaine TF, Sonenberg N. Elife. 2018 Feb 7;7. pii: 35034. doi: 10.7554/eLife.35034. PubMed |
| Lrp6 is a target of the PTH-activated alphaNAC transcriptional coregulator. Pellicelli M, Hariri H, Miller JA, St-Arnaud R. Biochim Biophys Acta Gene Regul Mech. 2018 Feb;1861(2):61-71. doi: 10.1016/j.bbagrm.2018.01.008. Epub 2018 Feb 3. PubMed |
| Picornavirus 2A protease regulates stress granule formation to facilitate viral translation. Yang X, Hu Z, Fan S, Zhang Q, Zhong Y, Guo D, Qin Y, Chen M. PLoS Pathog. 2018 Feb 7;14(2):e1006901. doi: 10.1371/journal.ppat.1006901. eCollection 2018 Feb. PubMed |
| The Role of Trio, a Rho Guanine Nucleotide Exchange Factor, in Glomerular Podocytes. Maier M, Baldwin C, Aoudjit L, Takano T. Int J Mol Sci. 2018 Feb 6;19(2). pii: ijms19020479. doi: 10.3390/ijms19020479. PubMed |
| Deguelin suppresses angiogenesis in human hepatocellular carcinoma by targeting HGF-c-Met pathway. Li M, Yu X, Li W, Liu T, Deng G, Liu W, Liu H, Gao F. Oncotarget. 2017 Oct 26;9(1):152-166. doi: 10.18632/oncotarget.22077. eCollection 2018 Jan 2. PubMed |
The TIA1 RNA-Binding Protein Family Regulates EIF2AK2-Mediated Stress Response and Cell Cycle Progression.
Meyer C, Garzia A, Mazzola M, Gerstberger S, Molina H, Tuschl T.
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| Intratumoral Delivery of Interferongamma-Secreting Mesenchymal Stromal Cells Repolarizes Tumor-Associated Macrophages and Suppresses Neuroblastoma Proliferation In Vivo. Relation T, Yi T, Guess AJ, La Perle K, Otsuru S, Hasgur S, Dominici M, Breuer C, Horwitz EM. Stem Cells. 2018 Jun;36(6):915-924. doi: 10.1002/stem.2801. Epub 2018 Feb 27. PubMed |
| microRNA-193a stimulates pancreatic cancer cell repopulation and metastasis through modulating TGF-beta2/TGF-betaRIII signalings. Fang C, Dai CY, Mei Z, Jiang MJ, Gu DN, Huang Q, Tian L. J Exp Clin Cancer Res. 2018 Feb 13;37(1):25. doi: 10.1186/s13046-018-0697-3. PubMed |
| SLAMF1 is required for TLR4-mediated TRAM-TRIF-dependent signaling in human macrophages. Yurchenko M, Skjesol A, Ryan L, Richard GM, Kandasamy RK, Wang N, Terhorst C, Husebye H, Espevik T. J Cell Biol. 2018 Apr 2;217(4):1411-1429. doi: 10.1083/jcb.201707027. Epub 2018 Feb 12. PubMed |
| Differential role of FL-BID and t-BID during verotoxin-1-induced apoptosis in Burkitt's lymphoma cells. Debernardi J, Hollville E, Lipinski M, Wiels J, Robert A. Oncogene. 2018 May;37(18):2410-2421. doi: 10.1038/s41388-018-0123-5. Epub 2018 Feb 14. PubMed |
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| SMARCB1 Deficiency Integrates Epigenetic Signals to Oncogenic Gene Expression Program Maintenance in Human Acute Myeloid Leukemia. Chatterjee SS, Biswas M, Boila LD, Banerjee D, Sengupta A. Mol Cancer Res. 2018 May;16(5):791-804. doi: 10.1158/1541-7786.MCR-17-0493. Epub 2018 Feb 26. PubMed |
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| FLT3-ITD induces expression of Pim kinases through STAT5 to confer resistance to the PI3K/Akt pathway inhibitors on leukemic cells by enhancing the mTORC1/Mcl-1 pathway. Okada K, Nogami A, Ishida S, Akiyama H, Chen C, Umezawa Y, Miura O. Oncotarget. 2017 Dec 4;9(10):8870-8886. doi: 10.18632/oncotarget.22926. eCollection 2018 Feb 6. PubMed |
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| Porcine MKRN1 Modulates the Replication and Pathogenesis of Porcine Circovirus Type 2 by Inducing Capsid Protein Ubiquitination and Degradation. Wang T, Du Q, Wu X, Niu Y, Guan L, Wang Z, Zhao X, Liu SL, Tong D, Huang Y. J Virol. 2018 May 14;92(11). pii: JVI.00100-18. doi: 10.1128/JVI.00100-18. Print 2018 Jun 1. PubMed |
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| PKM1 Confers Metabolic Advantages and Promotes Cell-Autonomous Tumor Cell Growth. Morita M, Sato T, Nomura M, Sakamoto Y, Inoue Y, Tanaka R, Ito S, Kurosawa K, Yamaguchi K, Sugiura Y, Takizaki H, Yamashita Y, Katakura R, Sato I, Kawai M, Okada Y, Watanabe H, Kondoh G, Matsumoto S, Kishimoto A, Obata M, Matsumoto M, Fukuhara T, Motohashi H, Suematsu M, Komatsu M, Nakayama KI, Watanabe T, Soga T, Shima H, Maemondo M, Tanuma N. Cancer Cell. 2018 Mar 12;33(3):355-367.e7. doi: 10.1016/j.ccell.2018.02.004. PubMed |
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| H5N1 Influenza A Virus PB1-F2 Relieves HAX-1-Mediated Restriction of Avian Virus Polymerase PA in Human Lung Cells. Mazel-Sanchez B, Boal-Carvalho I, Silva F, Dijkman R, Schmolke M. J Virol. 2018 May 14;92(11). pii: JVI.00425-18. doi: 10.1128/JVI.00425-18. Print 2018 Jun 1. PubMed |
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| Impairment of an Endothelial NAD(+)-H2S Signaling Network Is a Reversible Cause of Vascular Aging. Das A, Huang GX, Bonkowski MS, Longchamp A, Li C, Schultz MB, Kim LJ, Osborne B, Joshi S, Lu Y, Trevino-Villarreal JH, Kang MJ, Hung TT, Lee B, Williams EO, Igarashi M, Mitchell JR, Wu LE, Turner N, Arany Z, Guarente L, Sinclair DA. Cell. 2018 Mar 22;173(1):74-89.e20. doi: 10.1016/j.cell.2018.02.008. PubMed |
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| Profound Tissue Specificity in Proliferation Control Underlies Cancer Drivers and Aneuploidy Patterns. Sack LM, Davoli T, Li MZ, Li Y, Xu Q, Naxerova K, Wooten EC, Bernardi RJ, Martin TD, Chen T, Leng Y, Liang AC, Scorsone KA, Westbrook TF, Wong KK, Elledge SJ. Cell. 2018 Apr 5;173(2):499-514.e23. doi: 10.1016/j.cell.2018.02.037. Epub 2018 Mar 22. PubMed |
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| Molecular cloning, expression, and characterization of UDP N-acetyl-alpha-d-galactosamine: Polypeptide N-acetylgalactosaminyltransferase 4 from Cryptosporidium parvum. DeCicco RePass MA, Bhat N, Heimburg-Molinaro J, Bunnell S, Cummings RD, Ward HD. Mol Biochem Parasitol. 2018 Apr;221:56-65. doi: 10.1016/j.molbiopara.2018.03.002. Epub 2018 Mar 23. PubMed |
| LentiPro26: novel stable cell lines for constitutive lentiviral vector production. Tomas HA, Rodrigues AF, Carrondo MJT, Coroadinha AS. Sci Rep. 2018 Mar 27;8(1):5271. doi: 10.1038/s41598-018-23593-y. PubMed |
| Knockdown of HuR represses osteosarcoma cells migration, invasion and stemness through inhibition of YAP activation and increases susceptibility to chemotherapeutic agents. Xu W, Chen C, Xu R, Li Y, Hu R, Li Z, Zhu X. Biomed Pharmacother. 2018 Jun;102:587-593. doi: 10.1016/j.biopha.2018.03.098. Epub 2018 Apr 5. PubMed |
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| Induction, regulation and roles of neural adhesion molecule L1CAM in cellular senescence. Mrazkova B, Dzijak R, Imrichova T, Kyjacova L, Barath P, Dzubak P, Holub D, Hajduch M, Nahacka Z, Andera L, Holicek P, Vasicova P, Sapega O, Bartek J, Hodny Z. Aging (Albany NY). 2018 Mar 28;10(3):434-462. doi: 10.18632/aging.101404. PubMed |
| Genetic abrogation of immune checkpoints in antigen-specific cytotoxic T-lymphocyte as a potential alternative to blockade immunotherapy. Zhang C, Peng Y, Hublitz P, Zhang H, Dong T. Sci Rep. 2018 Apr 3;8(1):5549. doi: 10.1038/s41598-018-23803-7. PubMed |
| Metabolic enzyme PFKFB4 activates transcriptional coactivator SRC-3 to drive breast cancer. Dasgupta S, Rajapakshe K, Zhu B, Nikolai BC, Yi P, Putluri N, Choi JM, Jung SY, Coarfa C, Westbrook TF, Zhang XH, Foulds CE, Tsai SY, Tsai MJ, O'Malley BW. Nature. 2018 Apr;556(7700):249-254. doi: 10.1038/s41586-018-0018-1. Epub 2018 Apr 3. PubMed |
| Molecular Characterization and Clinical Relevance of Metabolic Expression Subtypes in Human Cancers. Peng X, Chen Z, Farshidfar F, Xu X, Lorenzi PL, Wang Y, Cheng F, Tan L, Mojumdar K, Du D, Ge Z, Li J, Thomas GV, Birsoy K, Liu L, Zhang H, Zhao Z, Marchand C, Weinstein JN, Bathe OF, Liang H. Cell Rep. 2018 Apr 3;23(1):255-269.e4. doi: 10.1016/j.celrep.2018.03.077. PubMed |
| Autophagy regulates testosterone synthesis by facilitating cholesterol uptake in Leydig cells. Gao F, Li G, Liu C, Gao H, Wang H, Liu W, Chen M, Shang Y, Wang L, Shi J, Xia W, Jiao J, Gao F, Li J, Chen L, Li W. J Cell Biol. 2018 Jun 4;217(6):2103-2119. doi: 10.1083/jcb.201710078. Epub 2018 Apr 4. PubMed |
| Decreased expression of SFRP2 promotes development of the pituitary corticotroph adenoma by upregulating Wnt signaling. Ren J, Jian F, Jiang H, Sun Y, Pan S, Gu C, Chen X, Wang W, Ning G, Bian L, Sun Q. Int J Oncol. 2018 Jun;52(6):1934-1946. doi: 10.3892/ijo.2018.4355. Epub 2018 Apr 3. PubMed |
| Impact of Nrf2 on tumour growth and drug sensitivity in oncogenic K-ras-transformed cells in vitro and in vivo. Shao J, Glorieux C, Liao J, Chen P, Lu W, Liang Z, Wen S, Hu Y, Huang P. Free Radic Res. 2018 Jun;52(6):661-671. doi: 10.1080/10715762.2018.1462494. Epub 2018 May 3. PubMed |
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| Disruption of NSD1 in Head and Neck Cancer Promotes Favorable Chemotherapeutic Responses Linked to Hypomethylation. Bui N, Huang JK, Bojorquez-Gomez A, Licon K, Sanchez KS, Tang SN, Beckett AN, Wang T, Zhang W, Shen JP, Kreisberg JF, Ideker T. Mol Cancer Ther. 2018 Jul;17(7):1585-1594. doi: 10.1158/1535-7163.MCT-17-0937. Epub 2018 Apr 10. PubMed |
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| Metformin alleviates human cellular aging by upregulating the endoplasmic reticulum glutathione peroxidase 7. Fang J, Yang J, Wu X, Zhang G, Li T, Wang X, Zhang H, Wang CC, Liu GH, Wang L. Aging Cell. 2018 Apr 16:e12765. doi: 10.1111/acel.12765. PubMed |
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| Fank1 and Jazf1 promote multiciliated cell differentiation in the mouse airway epithelium. Johnson JA, Watson JK, Nikolic MZ, Rawlins EL. Biol Open. 2018 Apr 16;7(4). pii: 7/4/bio033944. doi: 10.1242/bio.033944. PubMed |
| lincRNA-Cox2 regulates NLRP3 inflammasome and autophagy mediated neuroinflammation. Xue Z, Zhang Z, Liu H, Li W, Guo X, Zhang Z, Liu Y, Jia L, Li Y, Ren Y, Yang H, Zhang L, Zhang Q, Da Y, Hao J, Yao Z, Zhang R. Cell Death Differ. 2019 Jan;26(1):130-145. doi: 10.1038/s41418-018-0105-8. Epub 2018 Apr 17. PubMed |
| Methylation-induced silencing of SPG20 facilitates gastric cancer cell proliferation by activating the EGFR/MAPK pathway. Zhou Z, Wang W, Xie X, Song Y, Dang C, Zhang H. Biochem Biophys Res Commun. 2018 Jun 2;500(2):411-417. doi: 10.1016/j.bbrc.2018.04.089. Epub 2018 Apr 18. PubMed |
| An Integrated Genome-wide CRISPRa Approach to Functionalize lncRNAs in Drug Resistance. Bester AC, Lee JD, Chavez A, Lee YR, Nachmani D, Vora S, Victor J, Sauvageau M, Monteleone E, Rinn JL, Provero P, Church GM, Clohessy JG, Pandolfi PP. Cell. 2018 Apr 19;173(3):649-664.e20. doi: 10.1016/j.cell.2018.03.052. PubMed |
| RNA Binding Protein, HuR, Regulates SCN5A Expression Through Stabilizing MEF2C transcription factor mRNA. Zhou A, Shi G, Kang GJ, Xie A, Liu H, Jiang N, Liu M, Jeong EM, Dudley SC Jr. J Am Heart Assoc. 2018 Apr 20;7(9). pii: JAHA.117.007802. doi: 10.1161/JAHA.117.007802. PubMed |
| 14-3-3 proteins regulate desmosomal adhesion via plakophilins. Rietscher K, Keil R, Jordan A, Hatzfeld M. J Cell Sci. 2018 May 22;131(10). pii: jcs.212191. doi: 10.1242/jcs.212191. PubMed |
| Targeting GLP-1 receptor trafficking to improve agonist efficacy. Jones B, Buenaventura T, Kanda N, Chabosseau P, Owen BM, Scott R, Goldin R, Angkathunyakul N, Correa IR Jr, Bosco D, Johnson PR, Piemonti L, Marchetti P, Shapiro AMJ, Cochran BJ, Hanyaloglu AC, Inoue A, Tan T, Rutter GA, Tomas A, Bloom SR. Nat Commun. 2018 Apr 23;9(1):1602. doi: 10.1038/s41467-018-03941-2. PubMed |
| Adipose-Derived Mesenchymal Stem Cell Application Combined With Fibrin Matrix Promotes Structural and Functional Recovery Following Spinal Cord Injury in Rats. Mukhamedshina YO, Akhmetzyanova ER, Kostennikov AA, Zakirova EY, Galieva LR, Garanina EE, Rogozin AA, Kiassov AP, Rizvanov AA. Front Pharmacol. 2018 Apr 10;9:343. doi: 10.3389/fphar.2018.00343. eCollection 2018. PubMed |
| Pharmacological versus genetic inhibition of heme oxygenase-1 - the comparison of metalloporphyrins, shRNA and CRISPR/Cas9 system. Mucha O, Podkalicka P, Czarnek M, Biela A, Mieczkowski M, Kachamakova-Trojanowska N, Stepniewski J, Jozkowicz A, Dulak J, Loboda A. Acta Biochim Pol. 2018;65(2):277-286. doi: 10.18388/abp.2017_2542. Epub 2018 Apr 25. PubMed |
| A High-Content Screening of Anticancer Compounds Suggests the Multiple Tyrosine Kinase Inhibitor Ponatinib for Repurposing in Neuroblastoma Therapy. Sidarovich V, De Mariano M, Aveic S, Pancher M, Adami V, Gatto P, Pizzini S, Pasini L, Croce M, Parodi F, Cimmino F, Avitabile M, Emionite L, Cilli M, Ferrini S, Pagano A, Capasso M, Quattrone A, Tonini GP, Longo L. Mol Cancer Ther. 2018 Jul;17(7):1405-1415. doi: 10.1158/1535-7163.MCT-17-0841. Epub 2018 Apr 25. PubMed |
| Regulation of calretinin in malignant mesothelioma is mediated by septin 7 binding to the CALB2 promoter. Blum W, Pecze L, Rodriguez JW, Steinauer M, Schwaller B. BMC Cancer. 2018 Apr 27;18(1):475. doi: 10.1186/s12885-018-4385-7. PubMed |
RNA-guided transcriptional silencing in vivo with S. aureus CRISPR-Cas9 repressors.
Thakore PI, Kwon JB, Nelson CE, Rouse DC, Gemberling MP, Oliver ML, Gersbach CA.
Nat Commun. 2018 Apr 26;9(1):1674. doi: 10.1038/s41467-018-04048-4.
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| Endometrial Mesenchymal Stem/Stromal Cells Modulate the Macrophage Response to Implanted Polyamide/Gelatin Composite Mesh in Immunocompromised and Immunocompetent Mice. Darzi S, Deane JA, Nold CA, Edwards SE, Gough DJ, Mukherjee S, Gurung S, Tan KS, Vashi AV, Werkmeister JA, Gargett CE. Sci Rep. 2018 Apr 26;8(1):6554. doi: 10.1038/s41598-018-24919-6. PubMed |
| Universal Chimeric Antigen Receptors for Multiplexed and Logical Control of T Cell Responses. Cho JH, Collins JJ, Wong WW. Cell. 2018 May 31;173(6):1426-1438.e11. doi: 10.1016/j.cell.2018.03.038. Epub 2018 Apr 26. PubMed |
| Cationic Polymer-Mediated CRISPR/Cas9 Plasmid Delivery for Genome Editing. Zhang Z, Wan T, Chen Y, Chen Y, Sun H, Cao T, Songyang Z, Tang G, Wu C, Ping Y, Xu FJ, Huang J. Macromol Rapid Commun. 2019 Mar;40(5):e1800068. doi: 10.1002/marc.201800068. Epub 2018 Apr 30. PubMed |
| A Comprehensive Procedure to Evaluate the In Vitro Performance of the Putative Hemangioblastoma Neovascularization Using the Spheroid Sprouting Assay. Wang Y, Chen D, Chen M, Ji K, Ma D, Zhou L. J Vis Exp. 2018 Apr 12;(134). doi: 10.3791/57183. PubMed |
| TRPV4 inhibition prevents paclitaxel-induced neurotoxicity in preclinical models. Boehmerle W, Huehnchen P, Lee SLL, Harms C, Endres M. Exp Neurol. 2018 Aug;306:64-75. doi: 10.1016/j.expneurol.2018.04.014. Epub 2018 Apr 30. PubMed |
| Posttranslational regulation of CYP2J2 by nitric oxide. Park JW, Lee CM, Cheng JS, Morgan ET. Free Radic Biol Med. 2018 Jun;121:149-156. doi: 10.1016/j.freeradbiomed.2018.04.576. Epub 2018 Apr 30. PubMed |
| A Raf-Competitive K-Ras Binder Can Fail to Functionally Antagonize Signaling. Kauke MJ, Tisdale AW, Kelly RL, Braun CJ, Hemann MT, Wittrup KD. Mol Cancer Ther. 2018 Aug;17(8):1773-1780. doi: 10.1158/1535-7163.MCT-17-0645. Epub 2018 May 2. PubMed |
| Oncogene Lin28B increases chemosensitivity of colon cancer cells in a let-7-independent manner. Ma L, Zhao Q, Chen W, Zhang Y. Oncol Lett. 2018 May;15(5):6975-6981. doi: 10.3892/ol.2018.8250. Epub 2018 Mar 13. PubMed |
| PRC1 Fine-tunes Gene Repression and Activation to Safeguard Skin Development and Stem Cell Specification. Cohen I, Zhao D, Bar C, Valdes VJ, Dauber-Decker KL, Nguyen MB, Nakayama M, Rendl M, Bickmore WA, Koseki H, Zheng D, Ezhkova E. Cell Stem Cell. 2018 May 3;22(5):726-739.e7. doi: 10.1016/j.stem.2018.04.005. PubMed |
| Retinoid-Sensitive Epigenetic Regulation of the Hoxb Cluster Maintains Normal Hematopoiesis and Inhibits Leukemogenesis. Qian P, De Kumar B, He XC, Nolte C, Gogol M, Ahn Y, Chen S, Li Z, Xu H, Perry JM, Hu D, Tao F, Zhao M, Han Y, Hall K, Peak A, Paulson A, Zhao C, Venkatraman A, Box A, Perera A, Haug JS, Parmely T, Li H, Krumlauf R, Li L. Cell Stem Cell. 2018 May 3;22(5):740-754.e7. doi: 10.1016/j.stem.2018.04.012. PubMed |
| RBM14 is indispensable for pluripotency maintenance and mesoderm development of mouse embryonic stem cells. Chen G, Zhang D, Zhang L, Feng G, Zhang B, Wu Y, Li W, Zhang Y, Hu B. Biochem Biophys Res Commun. 2018 Jun 18;501(1):259-265. doi: 10.1016/j.bbrc.2018.04.231. Epub 2018 May 8. PubMed |
| Differential regulation of the pro-inflammatory biomarker, YKL-40/CHI3L1, by PTEN/Phosphoinositide 3-kinase and JAK2/STAT3 pathways in glioblastoma. Wang Y, Wong CW, Yan M, Li L, Liu T, Or PM, Tsui SK, Waye MM, Chan AM. Cancer Lett. 2018 Aug 10;429:54-65. doi: 10.1016/j.canlet.2018.04.040. Epub 2018 May 3. PubMed |
| RNA Helicase DDX1 Converts RNA G-Quadruplex Structures into R-Loops to Promote IgH Class Switch Recombination. Ribeiro de Almeida C, Dhir S, Dhir A, Moghaddam AE, Sattentau Q, Meinhart A, Proudfoot NJ. Mol Cell. 2018 May 17;70(4):650-662.e8. doi: 10.1016/j.molcel.2018.04.001. Epub 2018 May 3. PubMed |
| Tissue-selective restriction of RNA editing of CaV1.3 by splicing factor SRSF9. Huang H, Kapeli K, Jin W, Wong YP, Arumugam TV, Koh JH, Srimasorn S, Mallilankaraman K, Chua JJE, Yeo GW, Soong TW. Nucleic Acids Res. 2018 Aug 21;46(14):7323-7338. doi: 10.1093/nar/gky348. PubMed |
| Identification of the Intragenomic Promoter Controlling Hepatitis E Virus Subgenomic RNA Transcription. Ding Q, Nimgaonkar I, Archer NF, Bram Y, Heller B, Schwartz RE, Ploss A. MBio. 2018 May 8;9(3). pii: mBio.00769-18. doi: 10.1128/mBio.00769-18. PubMed |
| Inhibition of Tip60 Reduces Lytic and Latent Gene Expression of Kaposi's Sarcoma-Associated Herpes Virus (KSHV) and Proliferation of KSHV-Infected Tumor Cells. Simpson S, Fiches G, Jean MJ, Dieringer M, McGuinness J, John SP, Shamay M, Desai P, Zhu J, Santoso NG. Front Microbiol. 2018 Apr 24;9:788. doi: 10.3389/fmicb.2018.00788. eCollection 2018. PubMed |
| Identification of inhibitors synergizing gemcitabine sensitivity in the squamous subtype of pancreatic ductal adenocarcinoma (PDAC). Er JL, Goh PN, Lee CY, Tan YJ, Hii LW, Mai CW, Chung FF, Leong CO. Apoptosis. 2018 Jun;23(5-6):343-355. doi: 10.1007/s10495-018-1459-6. PubMed |
| Identification of a transporter complex responsible for the cytosolic entry of nitrogen-containing bisphosphonates. Yu Z, Surface LE, Park CY, Horlbeck MA, Wyant GA, Abu-Remaileh M, Peterson TR, Sabatini DM, Weissman JS, O'Shea EK. Elife. 2018 May 10;7. pii: 36620. doi: 10.7554/eLife.36620. PubMed |
| TGF-beta induces miR-100 and miR-125b but blocks let-7a through LIN28B controlling PDAC progression. Ottaviani S, Stebbing J, Frampton AE, Zagorac S, Krell J, de Giorgio A, Trabulo SM, Nguyen VTM, Magnani L, Feng H, Giovannetti E, Funel N, Gress TM, Jiao LR, Lombardo Y, Lemoine NR, Heeschen C, Castellano L. Nat Commun. 2018 May 10;9(1):1845. doi: 10.1038/s41467-018-03962-x. PubMed |
| Specific targeting of point mutations in EGFR L858R-positive lung cancer by CRISPR/Cas9. Cheung AH, Chow C, Zhang J, Zhou Y, Huang T, Ng KC, Or TC, Yao YY, Dong Y, Fung JM, Xiong L, Chan AK, Lung WR, Kang W, To KF. Lab Invest. 2018 Jul;98(7):968-976. doi: 10.1038/s41374-018-0056-1. Epub 2018 May 10. PubMed |
| Generation of hepatocyte- and endocrine pancreatic-like cells from human induced endodermal progenitor cells. Sambathkumar R, Akkerman R, Dastidar S, Roelandt P, Kumar M, Bajaj M, Mestre Rosa AR, Helsen N, Vanslembrouck V, Kalo E, Khurana S, Laureys J, Gysemans C, Faas MM, de Vos P, Verfaillie CM. PLoS One. 2018 May 11;13(5):e0197046. doi: 10.1371/journal.pone.0197046. eCollection 2018. PubMed |
| Genetic Engineering of Mesenchymal Stem Cells for Differential Matrix Deposition on 3D Woven Scaffolds. Huynh NPT, Brunger JM, Gloss CC, Moutos FT, Gersbach CA, Guilak F. Tissue Eng Part A. 2018 Oct;24(19-20):1531-1544. doi: 10.1089/ten.TEA.2017.0510. Epub 2018 Jul 13. PubMed |
| Regulation of BDNF Release by ARMS/Kidins220 through Modulation of Synaptotagmin-IV Levels. Lopez-Benito S, Sanchez-Sanchez J, Brito V, Calvo L, Lisa S, Torres-Valle M, Palko ME, Vicente-Garcia C, Fernandez-Fernandez S, Bolanos JP, Gines S, Tessarollo L, Arevalo JC. J Neurosci. 2018 Jun 6;38(23):5415-5428. doi: 10.1523/JNEUROSCI.1653-17.2018. Epub 2018 May 16. PubMed |
| Mxra8 is a receptor for multiple arthritogenic alphaviruses. Zhang R, Kim AS, Fox JM, Nair S, Basore K, Klimstra WB, Rimkunas R, Fong RH, Lin H, Poddar S, Crowe JE Jr, Doranz BJ, Fremont DH, Diamond MS. Nature. 2018 May;557(7706):570-574. doi: 10.1038/s41586-018-0121-3. Epub 2018 May 16. PubMed |
| Caspase-3 Regulates YAP-Dependent Cell Proliferation and Organ Size. Yosefzon Y, Soteriou D, Feldman A, Kostic L, Koren E, Brown S, Ankawa R, Sedov E, Glaser F, Fuchs Y. Mol Cell. 2018 May 17;70(4):573-587.e4. doi: 10.1016/j.molcel.2018.04.019. PubMed |
| The Bicarbonate Transporter SLC4A7 Plays a Key Role in Macrophage Phagosome Acidification. Sedlyarov V, Eichner R, Girardi E, Essletzbichler P, Goldmann U, Nunes-Hasler P, Srndic I, Moskovskich A, Heinz LX, Kartnig F, Bigenzahn JW, Rebsamen M, Kovarik P, Demaurex N, Superti-Furga G. Cell Host Microbe. 2018 Jun 13;23(6):766-774.e5. doi: 10.1016/j.chom.2018.04.013. Epub 2018 May 17. PubMed |
| Moderate UV Exposure Enhances Learning and Memory by Promoting a Novel Glutamate Biosynthetic Pathway in the Brain. Zhu H, Wang N, Yao L, Chen Q, Zhang R, Qian J, Hou Y, Guo W, Fan S, Liu S, Zhao Q, Du F, Zuo X, Guo Y, Xu Y, Li J, Xue T, Zhong K, Song X, Huang G, Xiong W. Cell. 2018 Jun 14;173(7):1716-1727.e17. doi: 10.1016/j.cell.2018.04.014. Epub 2018 May 17. PubMed |
| The NOTCH1/CD44 axis drives pathogenesis in a T cell acute lymphoblastic leukemia model. Garcia-Peydro M, Fuentes P, Mosquera M, Garcia-Leon MJ, Alcain J, Rodriguez A, Garcia de Miguel P, Menendez P, Weijer K, Spits H, Scadden DT, Cuesta-Mateos C, Munoz-Calleja C, Sanchez-Madrid F, Toribio ML. J Clin Invest. 2018 Jul 2;128(7):2802-2818. doi: 10.1172/JCI92981. Epub 2018 May 21. PubMed |
| Targeting the upstream transcriptional activator of PD-L1 as an alternative strategy in melanoma therapy. Zhu B, Tang L, Chen S, Yin C, Peng S, Li X, Liu T, Liu W, Han C, Stawski L, Xu ZX, Zhou G, Chen X, Gao X, Goding CR, Xu N, Cui R, Cao P. Oncogene. 2018 Sep;37(36):4941-4954. doi: 10.1038/s41388-018-0314-0. Epub 2018 May 22. PubMed |
| High-Titer Production of HIV-Based Lentiviral Vectors in Roller Bottles for Gene and Cell Therapy. Olgun HB, Tasyurek HM, Sanlioglu AD, Sanlioglu S. Methods Mol Biol. 2019;1879:323-345. doi: 10.1007/7651_2018_150. PubMed |
| Reduced Abeta secretion by human neurons under conditions of strongly increased BACE activity. Scholz D, Chernyshova Y, Uckert AK, Leist M. J Neurochem. 2018 Oct;147(2):256-274. doi: 10.1111/jnc.14467. Epub 2018 Sep 26. PubMed |
| Polyglutamine binding protein 1 (PQBP1) inhibits innate immune responses to cytosolic DNA. Shannon JL, Murphy MS, Kantheti U, Burnett JM, Hahn MG, Dorrity TJ, Bacas CJ, Mattice EB, Corpuz KD, Barker BR. Mol Immunol. 2018 Jul;99:182-190. doi: 10.1016/j.molimm.2018.05.014. Epub 2018 May 26. PubMed |
| IP6 is an HIV pocket factor that prevents capsid collapse and promotes DNA synthesis. Mallery DL, Marquez CL, McEwan WA, Dickson CF, Jacques DA, Anandapadamanaban M, Bichel K, Towers GJ, Saiardi A, Bocking T, James LC. Elife. 2018 May 31;7. pii: 35335. doi: 10.7554/eLife.35335. PubMed |
| Smc5/6 Antagonism by HBx Is an Evolutionarily Conserved Function of Hepatitis B Virus Infection in Mammals. Abdul F, Filleton F, Gerossier L, Paturel A, Hall J, Strubin M, Etienne L. J Virol. 2018 Jul 31;92(16). pii: JVI.00769-18. doi: 10.1128/JVI.00769-18. Print 2018 Aug 15. PubMed |
| Partial Inactivation of the Chromatin Remodelers SMARCA2 and SMARCA4 in Virus-Infected Cells by Caspase-Mediated Cleavage. Dudek AH, Pfaff F, Bolte H, Waguia Kontchou C, Schwemmle M. J Virol. 2018 Jul 31;92(16). pii: JVI.00343-18. doi: 10.1128/JVI.00343-18. Print 2018 Aug 15. PubMed |
| CRISPR/Cas9 Genome Editing of Epidermal Growth Factor Receptor Sufficiently Abolished Oncogenicity in Anaplastic Thyroid Cancer. Huang LC, Tam KW, Liu WN, Lin CY, Hsu KW, Hsieh WS, Chi WM, Lee AW, Yang JM, Lin CL, Lee CH. Dis Markers. 2018 Apr 12;2018:3835783. doi: 10.1155/2018/3835783. eCollection 2018. PubMed |
Human-Specific NOTCH2NL Genes Expand Cortical Neurogenesis through Delta/Notch Regulation.
Suzuki IK, Gacquer D, Van Heurck R, Kumar D, Wojno M, Bilheu A, Herpoel A, Lambert N, Cheron J, Polleux F, Detours V, Vanderhaeghen P.
Cell. 2018 May 31;173(6):1370-1384.e16. doi: 10.1016/j.cell.2018.03.067. Epub 2018 May 31.
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| Insights into the mechanisms underlying the inactivation of HIV-1 proviruses by CRISPR/Cas. Mefferd AL, Bogerd HP, Irwan ID, Cullen BR. Virology. 2018 Jul;520:116-126. doi: 10.1016/j.virol.2018.05.016. Epub 2018 May 29. PubMed |
| PAK1 regulates ATXN1 levels providing an opportunity to modify its toxicity in spinocerebellar ataxia type 1. Bondar VV, Adamski CJ, Onur TS, Tan Q, Wang L, Diaz-Garcia J, Park J, Orr HT, Botas J, Zoghbi HY. Hum Mol Genet. 2018 Aug 15;27(16):2863-2873. doi: 10.1093/hmg/ddy200. PubMed |
| Methylation of hypoxia-inducible factor (HIF)-1alpha by G9a/GLP inhibits HIF-1 transcriptional activity and cell migration. Bao L, Chen Y, Lai HT, Wu SY, Wang JE, Hatanpaa KJ, Raisanen JM, Fontenot M, Lega B, Chiang CM, Semenza GL, Wang Y, Luo W. Nucleic Acids Res. 2018 Jul 27;46(13):6576-6591. doi: 10.1093/nar/gky449. PubMed |
| Specificity of RNAi, LNA and CRISPRi as loss-of-function methods in transcriptional analysis. Stojic L, Lun ATL, Mangei J, Mascalchi P, Quarantotti V, Barr AR, Bakal C, Marioni JC, Gergely F, Odom DT. Nucleic Acids Res. 2018 Jul 6;46(12):5950-5966. doi: 10.1093/nar/gky437. PubMed |
Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR.
Walton ZE, Patel CH, Brooks RC, Yu Y, Ibrahim-Hashim A, Riddle M, Porcu A, Jiang T, Ecker BL, Tameire F, Koumenis C, Weeraratna AT, Welsh DK, Gillies R, Alwine JC, Zhang L, Powell JD, Dang CV.
Cell. 2018 Jun 28;174(1):72-87.e32. doi: 10.1016/j.cell.2018.05.009. Epub 2018 May 31.
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Chimeric antigen receptors that trigger phagocytosis.
Morrissey MA, Williamson AP, Steinbach AM, Roberts EW, Kern N, Headley MB, Vale R.
Elife. 2018 Jun 4;7. pii: 36688. doi: 10.7554/eLife.36688.
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| Gastrointestinal stromal tumor enhancers support a transcription factor network predictive of clinical outcome. Hemming ML, Lawlor MA, Zeid R, Lesluyes T, Fletcher JA, Raut CP, Sicinska ET, Chibon F, Armstrong SA, Demetri GD, Bradner JE. Proc Natl Acad Sci U S A. 2018 Jun 19;115(25):E5746-E5755. doi: 10.1073/pnas.1802079115. Epub 2018 Jun 4. PubMed |
| Temozolomide lymphodepletion enhances CAR abundance and correlates with antitumor efficacy against established glioblastoma. Suryadevara CM, Desai R, Abel ML, Riccione KA, Batich KA, Shen SH, Chongsathidkiet P, Gedeon PC, Elsamadicy AA, Snyder DJ, Herndon JE 2nd, Healy P, Archer GE, Choi BD, Fecci PE, Sampson JH, Sanchez-Perez L. Oncoimmunology. 2018 Feb 21;7(6):e1434464. doi: 10.1080/2162402X.2018.1434464. eCollection 2018. PubMed |
| Folate receptor 1 (FOLR1) targeted chimeric antigen receptor (CAR) T cells for the treatment of gastric cancer. Kim M, Pyo S, Kang CH, Lee CO, Lee HK, Choi SU, Park CH. PLoS One. 2018 Jun 6;13(6):e0198347. doi: 10.1371/journal.pone.0198347. eCollection 2018. PubMed |
| Frequent sgRNA-barcode recombination in single-cell perturbation assays. Xie S, Cooley A, Armendariz D, Zhou P, Hon GC. PLoS One. 2018 Jun 6;13(6):e0198635. doi: 10.1371/journal.pone.0198635. eCollection 2018. PubMed |
| Kaposi's Sarcoma-Associated Herpesvirus ORF68 Is a DNA Binding Protein Required for Viral Genome Cleavage and Packaging. Gardner MR, Glaunsinger BA. J Virol. 2018 Jul 31;92(16). pii: JVI.00840-18. doi: 10.1128/JVI.00840-18. Print 2018 Aug 15. PubMed |
| Pharmacological inhibition of dihydroorotate dehydrogenase induces apoptosis and differentiation in acute myeloid leukemia cells. Wu D, Wang W, Chen W, Lian F, Lang L, Huang Y, Xu Y, Zhang N, Chen Y, Liu M, Nussinov R, Cheng F, Lu W, Huang J. Haematologica. 2018 Sep;103(9):1472-1483. doi: 10.3324/haematol.2018.188185. Epub 2018 Jun 7. PubMed |
| The transcription factor Zfp90 regulates the self-renewal and differentiation of hematopoietic stem cells. Liu T, Kong WX, Tang XY, Xu M, Wang QH, Zhang B, Hu LD, Chen H. Cell Death Dis. 2018 Jun 7;9(6):677. doi: 10.1038/s41419-018-0721-8. PubMed |
A Network of Noncoding Regulatory RNAs Acts in the Mammalian Brain.
Kleaveland B, Shi CY, Stefano J, Bartel DP.
Cell. 2018 Jul 12;174(2):350-362.e17. doi: 10.1016/j.cell.2018.05.022. Epub 2018 Jun 7.
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| Nicotinamide adenine dinucleotide is transported into mammalian mitochondria. Davila A, Liu L, Chellappa K, Redpath P, Nakamaru-Ogiso E, Paolella LM, Zhang Z, Migaud ME, Rabinowitz JD, Baur JA. Elife. 2018 Jun 12;7. pii: 33246. doi: 10.7554/eLife.33246. PubMed |
| An immortalised mesenchymal stem cell line maintains mechano-responsive behaviour and can be used as a reporter of substrate stiffness. Galarza Torre A, Shaw JE, Wood A, Gilbert HTJ, Dobre O, Genever P, Brennan K, Richardson SM, Swift J. Sci Rep. 2018 Jun 12;8(1):8981. doi: 10.1038/s41598-018-27346-9. PubMed |
| Telomerase reverse transcriptase interference synergistically promotes tumor necrosis factorrelated apoptosisinducing ligandinduced oral squamous cell carcinoma apoptosis and suppresses proliferation in vitro and in vivo. Zhao X, Zhang C, Le Z, Zeng S, Pan C, Shi J, Wang J, Zhao X. Int J Mol Med. 2018 Sep;42(3):1283-1294. doi: 10.3892/ijmm.2018.3721. Epub 2018 Jun 7. PubMed |
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| Activity-Dependent Actin Remodeling at the Base of Dendritic Spines Promotes Microtubule Entry. Schatzle P, Esteves da Silva M, Tas RP, Katrukha EA, Hu HY, Wierenga CJ, Kapitein LC, Hoogenraad CC. Curr Biol. 2018 Jul 9;28(13):2081-2093.e6. doi: 10.1016/j.cub.2018.05.004. Epub 2018 Jun 14. PubMed |
| Cryptic exon splicing function of TARDBP interacts with autophagy in nervous tissue. Torres P, Ramirez-Nunez O, Romero-Guevara R, Bares G, Granado-Serrano AB, Ayala V, Boada J, Fontdevila L, Povedano M, Sanchis D, Pamplona R, Ferrer I, Portero-Otin M. Autophagy. 2018;14(8):1398-1403. doi: 10.1080/15548627.2018.1474311. Epub 2018 Jul 28. PubMed |
| Trehalose reduces retinal degeneration, neuroinflammation and storage burden caused by a lysosomal hydrolase deficiency. Lotfi P, Tse DY, Di Ronza A, Seymour ML, Martano G, Cooper JD, Pereira FA, Passafaro M, Wu SM, Sardiello M. Autophagy. 2018;14(8):1419-1434. doi: 10.1080/15548627.2018.1474313. Epub 2018 Jul 23. PubMed |
| Regulation of Epithelial Plasticity Determines Metastatic Organotropism in Pancreatic Cancer. Reichert M, Bakir B, Moreira L, Pitarresi JR, Feldmann K, Simon L, Suzuki K, Maddipati R, Rhim AD, Schlitter AM, Kriegsmann M, Weichert W, Wirth M, Schuck K, Schneider G, Saur D, Reynolds AB, Klein-Szanto AJ, Pehlivanoglu B, Memis B, Adsay NV, Rustgi AK. Dev Cell. 2018 Jun 18;45(6):696-711.e8. doi: 10.1016/j.devcel.2018.05.025. PubMed |
Transcription Factor-Mediated Differentiation of Human iPSCs into Neurons.
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Curr Protoc Cell Biol. 2018 Jun;79(1):e51. doi: 10.1002/cpcb.51. Epub 2018 May 18.
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| A multiprotein supercomplex controlling oncogenic signalling in lymphoma. Phelan JD, Young RM, Webster DE, Roulland S, Wright GW, Kasbekar M, Shaffer AL 3rd, Ceribelli M, Wang JQ, Schmitz R, Nakagawa M, Bachy E, Huang DW, Ji Y, Chen L, Yang Y, Zhao H, Yu X, Xu W, Palisoc MM, Valadez RR, Davies-Hill T, Wilson WH, Chan WC, Jaffe ES, Gascoyne RD, Campo E, Rosenwald A, Ott G, Delabie J, Rimsza LM, Rodriguez FJ, Estephan F, Holdhoff M, Kruhlak MJ, Hewitt SM, Thomas CJ, Pittaluga S, Oellerich T, Staudt LM. Nature. 2018 Aug;560(7718):387-391. doi: 10.1038/s41586-018-0290-0. Epub 2018 Jun 20. PubMed |
| Flap endonuclease 1 is involved in cccDNA formation in the hepatitis B virus. Kitamura K, Que L, Shimadu M, Koura M, Ishihara Y, Wakae K, Nakamura T, Watashi K, Wakita T, Muramatsu M. PLoS Pathog. 2018 Jun 21;14(6):e1007124. doi: 10.1371/journal.ppat.1007124. eCollection 2018 Jun. PubMed |
| X chromosome protects against bladder cancer in females via a KDM6A-dependent epigenetic mechanism. Kaneko S, Li X. Sci Adv. 2018 Jun 13;4(6):eaar5598. doi: 10.1126/sciadv.aar5598. eCollection 2018 Jun. PubMed |
| NEK1 loss-of-function mutation induces DNA damage accumulation in ALS patient-derived motoneurons. Higelin J, Catanese A, Semelink-Sedlacek LL, Oeztuerk S, Lutz AK, Bausinger J, Barbi G, Speit G, Andersen PM, Ludolph AC, Demestre M, Boeckers TM. Stem Cell Res. 2018 Jul;30:150-162. doi: 10.1016/j.scr.2018.06.005. Epub 2018 Jun 12. PubMed |
| Transbilayer phospholipid movement facilitates the translocation of annexin across membranes. Stewart SE, Ashkenazi A, Williamson A, Rubinsztein DC, Moreau K. J Cell Sci. 2018 Jul 19;131(14). pii: jcs.217034. doi: 10.1242/jcs.217034. PubMed |
| A Ca(2+)-stimulated exosome release pathway in cancer cells is regulated by Munc13-4. Messenger SW, Woo SS, Sun Z, Martin TFJ. J Cell Biol. 2018 Aug 6;217(8):2877-2890. doi: 10.1083/jcb.201710132. Epub 2018 Jun 21. PubMed |
| Apoptotic Cell-Derived Extracellular Vesicles Promote Malignancy of Glioblastoma Via Intercellular Transfer of Splicing Factors. Pavlyukov MS, Yu H, Bastola S, Minata M, Shender VO, Lee Y, Zhang S, Wang J, Komarova S, Wang J, Yamaguchi S, Alsheikh HA, Shi J, Chen D, Mohyeldin A, Kim SH, Shin YJ, Anufrieva K, Evtushenko EG, Antipova NV, Arapidi GP, Govorun V, Pestov NB, Shakhparonov MI, Lee LJ, Nam DH, Nakano I. Cancer Cell. 2018 Jul 9;34(1):119-135.e10. doi: 10.1016/j.ccell.2018.05.012. Epub 2018 Jun 21. PubMed |
| An in vivo model for thyroid regeneration and folliculogenesis. Iwadate M, Takizawa Y, Shirai YT, Kimura S. Lab Invest. 2018 Sep;98(9):1126-1132. doi: 10.1038/s41374-018-0068-x. Epub 2018 Jun 26. PubMed |
| Epstein-Barr virus-encoded EBNA2 alters immune checkpoint PD-L1 expression by downregulating miR-34a in B-cell lymphomas. Anastasiadou E, Stroopinsky D, Alimperti S, Jiao AL, Pyzer AR, Cippitelli C, Pepe G, Severa M, Rosenblatt J, Etna MP, Rieger S, Kempkes B, Coccia EM, Sui SJH, Chen CS, Uccini S, Avigan D, Faggioni A, Trivedi P, Slack FJ. Leukemia. 2019 Jan;33(1):132-147. doi: 10.1038/s41375-018-0178-x. Epub 2018 Jun 26. PubMed |
Multimodal cell tracking from systemic administration to tumour growth by combining gold nanorods and reporter genes.
Comenge J, Sharkey J, Fragueiro O, Wilm B, Brust M, Murray P, Levy R, Plagge A.
Elife. 2018 Jun 27;7. pii: 33140. doi: 10.7554/eLife.33140.
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| Transcription factor NFE2L2/NRF2 modulates chaperone-mediated autophagy through the regulation of LAMP2A. Pajares M, Rojo AI, Arias E, Diaz-Carretero A, Cuervo AM, Cuadrado A. Autophagy. 2018;14(8):1310-1322. doi: 10.1080/15548627.2018.1474992. Epub 2018 Jul 26. PubMed |
| Keratinocyte differentiation induces APOBEC3A, 3B, and mitochondrial DNA hypermutation. Wakae K, Nishiyama T, Kondo S, Izuka T, Que L, Chen C, Kase K, Kitamura K, Mohiuddin M, Wang Z, Ahasan MM, Nakamura M, Fujiwara H, Yoshizaki T, Hosomochi K, Tajima A, Nakahara T, Kiyono T, Muramatsu M. Sci Rep. 2018 Jun 27;8(1):9745. doi: 10.1038/s41598-018-27930-z. PubMed |
| Reprogramming the murine colon cancer microenvironment using lentivectors encoding shRNA against IL-10 as a component of a potent DC-based chemoimmunotherapy. Rossowska J, Anger N, Szczygiel A, Mierzejewska J, Pajtasz-Piasecka E. J Exp Clin Cancer Res. 2018 Jun 28;37(1):126. doi: 10.1186/s13046-018-0799-y. PubMed |
| Promoter interactome of human embryonic stem cell-derived cardiomyocytes connects GWAS regions to cardiac gene networks. Choy MK, Javierre BM, Williams SG, Baross SL, Liu Y, Wingett SW, Akbarov A, Wallace C, Freire-Pritchett P, Rugg-Gunn PJ, Spivakov M, Fraser P, Keavney BD. Nat Commun. 2018 Jun 28;9(1):2526. doi: 10.1038/s41467-018-04931-0. PubMed |
| CBFbeta-SMMHC Inhibition Triggers Apoptosis by Disrupting MYC Chromatin Dynamics in Acute Myeloid Leukemia. Pulikkan JA, Hegde M, Ahmad HM, Belaghzal H, Illendula A, Yu J, O'Hagan K, Ou J, Muller-Tidow C, Wolfe SA, Zhu LJ, Dekker J, Bushweller JH, Castilla LH. Cell. 2018 Jun 28;174(1):172-186.e21. doi: 10.1016/j.cell.2018.05.048. PubMed |
| Four Key Steps Control Glycolytic Flux in Mammalian Cells. Tanner LB, Goglia AG, Wei MH, Sehgal T, Parsons LR, Park JO, White E, Toettcher JE, Rabinowitz JD. Cell Syst. 2018 Jul 25;7(1):49-62.e8. doi: 10.1016/j.cels.2018.06.003. Epub 2018 Jun 27. PubMed |
| IKZF1 Enhances Immune Infiltrate Recruitment in Solid Tumors and Susceptibility to Immunotherapy. Chen JC, Perez-Lorenzo R, Saenger YM, Drake CG, Christiano AM. Cell Syst. 2018 Jul 25;7(1):92-103.e4. doi: 10.1016/j.cels.2018.05.020. Epub 2018 Jun 27. PubMed |
| miR-876-3p regulates glucose homeostasis and insulin sensitivity by targeting adiponectin. Rajan S, Panzade G, Srivastava A, Shankar K, Pandey R, Kumar D, Gupta S, Gupta A, Varshney S, Beg M, Mishra RK, Shankar R, Gaikwad AN. J Endocrinol. 2018 Jul 2. pii: JOE-17-0387. doi: 10.1530/JOE-17-0387. PubMed |
| Synthetic far-red light-mediated CRISPR-dCas9 device for inducing functional neuronal differentiation. Shao J, Wang M, Yu G, Zhu S, Yu Y, Heng BC, Wu J, Ye H. Proc Natl Acad Sci U S A. 2018 Jul 17;115(29):E6722-E6730. doi: 10.1073/pnas.1802448115. Epub 2018 Jul 2. PubMed |
| MicroRNAs Overcome Cell Fate Barrier by Reducing EZH2-Controlled REST Stability during Neuronal Conversion of Human Adult Fibroblasts. Lee SW, Oh YM, Lu YL, Kim WK, Yoo AS. Dev Cell. 2018 Jul 2;46(1):73-84.e7. doi: 10.1016/j.devcel.2018.06.007. PubMed |
| Activation of the endoplasmic reticulum stress sensor IRE1alpha by the vaccine adjuvant AS03 contributes to its immunostimulatory properties. Givord C, Welsby I, Detienne S, Thomas S, Assabban A, Lima Silva V, Molle C, Gineste R, Vermeersch M, Perez-Morga D, Leo O, Collignon C, Didierlaurent AM, Goriely S. NPJ Vaccines. 2018 Jun 28;3:20. doi: 10.1038/s41541-018-0058-4. eCollection 2018. PubMed |
| Transcription factor induced conversion of human fibroblasts towards the hair cell lineage. Duran Alonso MB, Lopez Hernandez I, de la Fuente MA, Garcia-Sancho J, Giraldez F, Schimmang T. PLoS One. 2018 Jul 6;13(7):e0200210. doi: 10.1371/journal.pone.0200210. eCollection 2018. PubMed |
| Mapping Active Gene-Regulatory Regions in Human Repopulating Long-Term HSCs. Wunsche P, Eckert ESP, Holland-Letz T, Paruzynski A, Hotz-Wagenblatt A, Fronza R, Rath T, Gil-Farina I, Schmidt M, von Kalle C, Klein C, Ball CR, Herbst F, Glimm H. Cell Stem Cell. 2018 Jul 5;23(1):132-146.e9. doi: 10.1016/j.stem.2018.06.003. PubMed |
| MicroRNA-132 provides neuroprotection for tauopathies via multiple signaling pathways. El Fatimy R, Li S, Chen Z, Mushannen T, Gongala S, Wei Z, Balu DT, Rabinovsky R, Cantlon A, Elkhal A, Selkoe DJ, Sonntag KC, Walsh DM, Krichevsky AM. Acta Neuropathol. 2018 Oct;136(4):537-555. doi: 10.1007/s00401-018-1880-5. Epub 2018 Jul 7. PubMed |
| Angiotropism and extravascular migratory metastasis in cutaneous and uveal melanoma progression in a zebrafish model. Fornabaio G, Barnhill RL, Lugassy C, Bentolila LA, Cassoux N, Roman-Roman S, Alsafadi S, Del Bene F. Sci Rep. 2018 Jul 11;8(1):10448. doi: 10.1038/s41598-018-28515-6. PubMed |
| Myosin X is required for efficient melanoblast migration and melanoma initiation and metastasis. Tokuo H, Bhawan J, Coluccio LM. Sci Rep. 2018 Jul 11;8(1):10449. doi: 10.1038/s41598-018-28717-y. PubMed |
| Human Cytomegalovirus Tropism Modulator UL148 Interacts with SEL1L, a Cellular Factor That Governs Endoplasmic Reticulum-Associated Degradation of the Viral Envelope Glycoprotein gO. Nguyen CC, Siddiquey MNA, Zhang H, Li G, Kamil JP. J Virol. 2018 Aug 29;92(18). pii: JVI.00688-18. doi: 10.1128/JVI.00688-18. Print 2018 Sep 15. PubMed |
| Assembling the jigsaw puzzle: CBX2 isoform 2 and its targets in disorders/differences of sex development. Sproll P, Eid W, Gomes CR, Mendonca BB, Gomes NL, Costa EM, Biason-Lauber A. Mol Genet Genomic Med. 2018 Sep;6(5):785-795. doi: 10.1002/mgg3.445. Epub 2018 Jul 11. PubMed |
| Vesicular stomatitis virus G protein transmembrane region is crucial for the hemi-fusion to full fusion transition. Ci Y, Yang Y, Xu C, Shi L. Sci Rep. 2018 Jul 13;8(1):10669. doi: 10.1038/s41598-018-28868-y. PubMed |
| EZH2-Mediated Primary Cilium Deconstruction Drives Metastatic Melanoma Formation. Zingg D, Debbache J, Pena-Hernandez R, Antunes AT, Schaefer SM, Cheng PF, Zimmerli D, Haeusel J, Calcada RR, Tuncer E, Zhang Y, Bossart R, Wong KK, Basler K, Dummer R, Santoro R, Levesque MP, Sommer L. Cancer Cell. 2018 Jul 9;34(1):69-84.e14. doi: 10.1016/j.ccell.2018.06.001. Epub 2018 Jun 28. PubMed |
| Mutant ASXL1 cooperates with BAP1 to promote myeloid leukaemogenesis. Asada S, Goyama S, Inoue D, Shikata S, Takeda R, Fukushima T, Yonezawa T, Fujino T, Hayashi Y, Kawabata KC, Fukuyama T, Tanaka Y, Yokoyama A, Yamazaki S, Kozuka-Hata H, Oyama M, Kojima S, Kawazu M, Mano H, Kitamura T. Nat Commun. 2018 Jul 16;9(1):2733. doi: 10.1038/s41467-018-05085-9. PubMed |
| Deguelin attenuates non-small cell lung cancer cell metastasis through inhibiting the CtsZ/FAK signaling pathway. Li W, Yu X, Ma X, Xie L, Xia Z, Liu L, Yu X, Wang J, Zhou H, Zhou X, Yang Y, Liu H. Cell Signal. 2018 Oct;50:131-141. doi: 10.1016/j.cellsig.2018.07.001. Epub 2018 Jul 7. PubMed |
| Unique BIR domain sets determine inhibitor of apoptosis protein-driven cell death and NOD2 complex signal specificity. Chirieleison SM, Rathkey JK, Abbott DW. Sci Signal. 2018 Jul 17;11(539). pii: 11/539/eaao3964. doi: 10.1126/scisignal.aao3964. PubMed |
| Detection of Succinate by Intestinal Tuft Cells Triggers a Type 2 Innate Immune Circuit. Nadjsombati MS, McGinty JW, Lyons-Cohen MR, Jaffe JB, DiPeso L, Schneider C, Miller CN, Pollack JL, Nagana Gowda GA, Fontana MF, Erle DJ, Anderson MS, Locksley RM, Raftery D, von Moltke J. Immunity. 2018 Jul 17;49(1):33-41.e7. doi: 10.1016/j.immuni.2018.06.016. PubMed |
| MiR-129 regulates growth and invasion by targeting MAL2 in papillary thyroid carcinoma. Gao X, Chen Z, Li A, Zhang X, Cai X. Biomed Pharmacother. 2018 Sep;105:1072-1078. doi: 10.1016/j.biopha.2018.06.050. Epub 2018 Jun 19. PubMed |
| Shieldin complex promotes DNA end-joining and counters homologous recombination in BRCA1-null cells. Dev H, Chiang TW, Lescale C, de Krijger I, Martin AG, Pilger D, Coates J, Sczaniecka-Clift M, Wei W, Ostermaier M, Herzog M, Lam J, Shea A, Demir M, Wu Q, Yang F, Fu B, Lai Z, Balmus G, Belotserkovskaya R, Serra V, O'Connor MJ, Bruna A, Beli P, Pellegrini L, Caldas C, Deriano L, Jacobs JJL, Galanty Y, Jackson SP. Nat Cell Biol. 2018 Aug;20(8):954-965. doi: 10.1038/s41556-018-0140-1. Epub 2018 Jul 18. PubMed |
| Single Copy Transgene Integration in a Transcriptionally Active Site for Recombinant Protein Synthesis. O'Brien SA, Lee K, Fu HY, Lee Z, Le TS, Stach CS, McCann MG, Zhang AQ, Smanski MJ, Somia NV, Hu WS. Biotechnol J. 2018 Oct;13(10):e1800226. doi: 10.1002/biot.201800226. Epub 2018 Jul 30. PubMed |
| A genome-scale CRISPR-Cas9 screening in myeloma cells identifies regulators of immunomodulatory drug sensitivity. Liu J, Song T, Zhou W, Xing L, Wang S, Ho M, Peng Z, Tai YT, Hideshima T, Anderson KC, Cang Y. Leukemia. 2019 Jan;33(1):171-180. doi: 10.1038/s41375-018-0205-y. Epub 2018 Jul 19. PubMed |
| NAT6 acetylates the N-terminus of different forms of actin. Wiame E, Tahay G, Tyteca D, Vertommen D, Stroobant V, Bommer GT, Van Schaftingen E. FEBS J. 2018 Sep;285(17):3299-3316. doi: 10.1111/febs.14605. Epub 2018 Aug 13. PubMed |
| Risk SNP-Mediated Promoter-Enhancer Switching Drives Prostate Cancer through lncRNA PCAT19. Hua JT, Ahmed M, Guo H, Zhang Y, Chen S, Soares F, Lu J, Zhou S, Wang M, Li H, Larson NB, McDonnell SK, Patel PS, Liang Y, Yao CQ, van der Kwast T, Lupien M, Feng FY, Zoubeidi A, Tsao MS, Thibodeau SN, Boutros PC, He HH. Cell. 2018 Jul 26;174(3):564-575.e18. doi: 10.1016/j.cell.2018.06.014. Epub 2018 Jul 19. PubMed |
| MUNC, an Enhancer RNA Upstream from the MYOD Gene, Induces a Subgroup of Myogenic Transcripts in trans Independently of MyoD. Cichewicz MA, Kiran M, Przanowska RK, Sobierajska E, Shibata Y, Dutta A. Mol Cell Biol. 2018 Sep 28;38(20). pii: MCB.00655-17. doi: 10.1128/MCB.00655-17. Print 2018 Oct 15. PubMed |
| Exposure to galactic cosmic radiation compromises DNA repair and increases the potential for oncogenic chromosomal rearrangement in bronchial epithelial cells. Li Z, Jella KK, Jaafar L, Li S, Park S, Story MD, Wang H, Wang Y, Dynan WS. Sci Rep. 2018 Jul 23;8(1):11038. doi: 10.1038/s41598-018-29350-5. PubMed |
The Human Cytomegalovirus Endoplasmic Reticulum-Resident Glycoprotein UL148 Activates the Unfolded Protein Response.
Siddiquey MNA, Zhang H, Nguyen CC, Domma AJ, Kamil JP.
J Virol. 2018 Sep 26;92(20). pii: JVI.00896-18. doi: 10.1128/JVI.00896-18. Print 2018 Oct 15.
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| 3D-cultured neural stem cell microarrays on a micropillar chip for high-throughput developmental neurotoxicology. Joshi P, Yu KN, Kang SY, Kwon SJ, Kwon PS, Dordick JS, Kothapalli CR, Lee MY. Exp Cell Res. 2018 Sep 15;370(2):680-691. doi: 10.1016/j.yexcr.2018.07.034. Epub 2018 Jul 24. PubMed |
| Concerted ESCRT and clathrin recruitment waves define the timing and morphology of intraluminal vesicle formation. Wenzel EM, Schultz SW, Schink KO, Pedersen NM, Nahse V, Carlson A, Brech A, Stenmark H, Raiborg C. Nat Commun. 2018 Jul 26;9(1):2932. doi: 10.1038/s41467-018-05345-8. PubMed |
| Frontline Science: RIP2 promotes house dust mite-induced allergic airway inflammation. Miller MH, Shehat MG, Alcedo KP, Spinel LP, Soulakova J, Tigno-Aranjuez JT. J Leukoc Biol. 2018 Sep;104(3):447-459. doi: 10.1002/JLB.4HI0118-017RR. Epub 2018 Jul 27. PubMed |
| An Unbiased Screen for Human Cytomegalovirus Identifies Neuropilin-2 as a Central Viral Receptor. Martinez-Martin N, Marcandalli J, Huang CS, Arthur CP, Perotti M, Foglierini M, Ho H, Dosey AM, Shriver S, Payandeh J, Leitner A, Lanzavecchia A, Perez L, Ciferri C. Cell. 2018 Aug 23;174(5):1158-1171.e19. doi: 10.1016/j.cell.2018.06.028. Epub 2018 Jul 26. PubMed |
| A Phosphatidylinositol 3-Kinase Effector Alters Phagosomal Maturation to Promote Intracellular Growth of Francisella. Ledvina HE, Kelly KA, Eshraghi A, Plemel RL, Peterson SB, Lee B, Steele S, Adler M, Kawula TH, Merz AJ, Skerrett SJ, Celli J, Mougous JD. Cell Host Microbe. 2018 Aug 8;24(2):285-295.e8. doi: 10.1016/j.chom.2018.07.003. Epub 2018 Jul 26. PubMed |
| Monitoring implantable immunoisolation devices with intrinsic fluorescence of genipin. Santos-Vizcaino E, Haley H, Gonzalez-Pujana A, Orive G, Hernandez RM, Luker GD, Pedraz JL. J Biophotonics. 2019 Apr;12(4):e201800170. doi: 10.1002/jbio.201800170. Epub 2018 Sep 25. PubMed |
The actin cytoskeletal architecture of estrogen receptor positive breast cancer cells suppresses invasion.
Padilla-Rodriguez M, Parker SS, Adams DG, Westerling T, Puleo JI, Watson AW, Hill SM, Noon M, Gaudin R, Aaron J, Tong D, Roe DJ, Knudsen B, Mouneimne G.
Nat Commun. 2018 Jul 30;9(1):2980. doi: 10.1038/s41467-018-05367-2.
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| Programmable DNA repair with CRISPRa/i enhanced homology-directed repair efficiency with a single Cas9. Ye L, Wang C, Hong L, Sun N, Chen D, Chen S, Han F. Cell Discov. 2018 Jul 24;4:46. doi: 10.1038/s41421-018-0049-7. eCollection 2018. PubMed |
Identification of SMCHD1 domains for nuclear localization, homo-dimerization, and protein cleavage.
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Skelet Muscle. 2018 Aug 2;8(1):24. doi: 10.1186/s13395-018-0172-z.
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| JMJD2B/KDM4B inactivation in adipose tissues accelerates obesity and systemic metabolic abnormalities. Kang C, Saso K, Ota K, Kawazu M, Ueda T, Okada H. Genes Cells. 2018 Sep;23(9):767-777. doi: 10.1111/gtc.12627. Epub 2018 Aug 2. PubMed |
| CRMP4a suppresses cell motility by sequestering RhoA activity in prostate cancer cells. Li C, Xu H, Xiao L, Zhu H, Zhang G, Wei W, Li K, Cao X, Shen D, Holzbeierlein J, Li B. Cancer Biol Ther. 2018 Aug 6:1-11. doi: 10.1080/15384047.2018.1491507. PubMed |
| HDAC11 suppresses the thermogenic program of adipose tissue via BRD2. Bagchi RA, Ferguson BS, Stratton MS, Hu T, Cavasin MA, Sun L, Lin YH, Liu D, Londono P, Song K, Pino MF, Sparks LM, Smith SR, Scherer PE, Collins S, Seto E, McKinsey TA. JCI Insight. 2018 Aug 9;3(15). pii: 120159. doi: 10.1172/jci.insight.120159. eCollection 2018 Aug 9. PubMed |
| RNA binding protein HuR regulates extracellular matrix gene expression and pH homeostasis independent of controlling HIF-1alpha signaling in nucleus pulposus cells. Pan H, Strickland A, Madhu V, Johnson ZI, Chand SN, Brody JR, Fertala A, Zheng Z, Shapiro IM, Risbud MV. Matrix Biol. 2019 Apr;77:23-40. doi: 10.1016/j.matbio.2018.08.003. Epub 2018 Aug 7. PubMed |
| AIF promotes a JNK1-mediated cadherin switch independently of respiratory chain stabilization. Scott AJ, Walker SA, Krank JJ, Wilkinson AS, Johnson KM, Lewis EM, Wilkinson JC. J Biol Chem. 2018 Sep 21;293(38):14707-14722. doi: 10.1074/jbc.RA118.004022. Epub 2018 Aug 9. PubMed |
| CXCL1 Derived from Mammary Fibroblasts Promotes Progression of Mammary Lesions to Invasive Carcinoma through CXCR2 Dependent Mechanisms. Bernard S, Myers M, Fang WB, Zinda B, Smart C, Lambert D, Zou A, Fan F, Cheng N. J Mammary Gland Biol Neoplasia. 2018 Dec;23(4):249-267. doi: 10.1007/s10911-018-9407-1. Epub 2018 Aug 9. PubMed |
| Genome Editing of Human Primary Keratinocytes by CRISPR/Cas9 Reveals an Essential Role of the NLRP1 Inflammasome in UVB Sensing. Fenini G, Grossi S, Contassot E, Biedermann T, Reichmann E, French LE, Beer HD. J Invest Dermatol. 2018 Dec;138(12):2644-2652. doi: 10.1016/j.jid.2018.07.016. Epub 2018 Aug 7. PubMed |
| B lymphocyte-induced maturation protein 1 controls TH9 cell development, IL-9 production, and allergic inflammation. Benevides L, Costa RS, Tavares LA, Russo M, Martins GA, da Silva LLP, Arruda LK, Cunha FQ, Carregaro V, Silva JS. J Allergy Clin Immunol. 2019 Mar;143(3):1119-1130.e3. doi: 10.1016/j.jaci.2018.06.046. Epub 2018 Aug 7. PubMed |
| Targeting AURKA-CDC25C axis to induce synthetic lethality in ARID1A-deficient colorectal cancer cells. Wu C, Lyu J, Yang EJ, Liu Y, Zhang B, Shim JS. Nat Commun. 2018 Aug 10;9(1):3212. doi: 10.1038/s41467-018-05694-4. PubMed |
| Evaluating Nonintegrating Lentiviruses as Safe Vectors for Noninvasive Reporter-Based Molecular Imaging of Multipotent Mesenchymal Stem Cells. Hamilton AM, Foster PJ, Ronald JA. Hum Gene Ther. 2018 Oct;29(10):1213-1225. doi: 10.1089/hum.2018.111. Epub 2018 Sep 14. PubMed |
| Triggered Cell-Cell Fusion Assay for Cytoplasmic and Organelle Intermixing Studies. Feliciano D, Nixon-Abell J, Lippincott-Schwartz J. Curr Protoc Cell Biol. 2018 Dec;81(1):e61. doi: 10.1002/cpcb.61. Epub 2018 Aug 13. PubMed |
| Role of c-Myb in the regulation of natural killer cell activity. Shin HW, Lee YJ, Kim J. Biochem Biophys Res Commun. 2018 Sep 18;503(4):2807-2813. doi: 10.1016/j.bbrc.2018.08.044. Epub 2018 Aug 10. PubMed |
| SF1-Specific AMPKalpha1 Deletion Protects Against Diet-Induced Obesity. Seoane-Collazo P, Roa J, Rial-Pensado E, Linares-Pose L, Beiroa D, Ruiz-Pino F, Lopez-Gonzalez T, Morgan DA, Pardavila JA, Sanchez-Tapia MJ, Martinez-Sanchez N, Contreras C, Fidalgo M, Dieguez C, Coppari R, Rahmouni K, Nogueiras R, Tena-Sempere M, Lopez M. Diabetes. 2018 Nov;67(11):2213-2226. doi: 10.2337/db17-1538. Epub 2018 Aug 13. PubMed |
| Drug-based perturbation screen uncovers synergistic drug combinations in Burkitt lymphoma. Tomska K, Kurilov R, Lee KS, Hullein J, Lukas M, Sellner L, Walther T, Wagner L, Oles M, Brors B, Huber W, Zenz T. Sci Rep. 2018 Aug 13;8(1):12046. doi: 10.1038/s41598-018-30509-3. PubMed |
| Gambogic Acid and Its Analogs Inhibit Gap Junctional Intercellular Communication. Choi EJ, Yeo JH, Yoon SM, Lee J. Front Pharmacol. 2018 Jul 30;9:814. doi: 10.3389/fphar.2018.00814. eCollection 2018. PubMed |
Long non-coding RNA H19 regulates endothelial cell aging via inhibition of STAT3 signalling.
Hofmann P, Sommer J, Theodorou K, Kirchhof L, Fischer A, Li Y, Perisic L, Hedin U, Maegdefessel L, Dimmeler S, Boon RA.
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| Complex bile duct network formation within liver decellularized extracellular matrix hydrogels. Lewis PL, Su J, Yan M, Meng F, Glaser SS, Alpini GD, Green RM, Sosa-Pineda B, Shah RN. Sci Rep. 2018 Aug 15;8(1):12220. doi: 10.1038/s41598-018-30433-6. PubMed |
| Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy. Logue SE, McGrath EP, Cleary P, Greene S, Mnich K, Almanza A, Chevet E, Dwyer RM, Oommen A, Legembre P, Godey F, Madden EC, Leuzzi B, Obacz J, Zeng Q, Patterson JB, Jager R, Gorman AM, Samali A. Nat Commun. 2018 Aug 15;9(1):3267. doi: 10.1038/s41467-018-05763-8. PubMed |
| Axoneme polyglutamylation regulated by Joubert syndrome protein ARL13B controls ciliary targeting of signaling molecules. He K, Ma X, Xu T, Li Y, Hodge A, Zhang Q, Torline J, Huang Y, Zhao J, Ling K, Hu J. Nat Commun. 2018 Aug 17;9(1):3310. doi: 10.1038/s41467-018-05867-1. PubMed |
| Plasmalogens Inhibit Endocytosis of Toll-like Receptor 4 to Attenuate the Inflammatory Signal in Microglial Cells. Ali F, Hossain MS, Sejimo S, Akashi K. Mol Neurobiol. 2018 Aug 20. pii: 10.1007/s12035-018-1307-2. doi: 10.1007/s12035-018-1307-2. PubMed |
| Rapamycin Upregulates Connective Tissue Growth Factor Expression in Hepatic Progenitor Cells Through TGF-beta-Smad2 Dependent Signaling. Wu Y, Wang W, Peng XM, He Y, Xiong YX, Liang HF, Chu L, Zhang BX, Ding ZY, Chen XP. Front Pharmacol. 2018 Aug 8;9:877. doi: 10.3389/fphar.2018.00877. eCollection 2018. PubMed |
| Nrf2 Signaling in Sodium Azide-Treated Oligodendrocytes Restores Mitochondrial Functions. Liessem-Schmitz A, Teske N, Scheld M, Nyamoya S, Zendedel A, Beyer C, Clarner T, Fragoulis A. J Mol Neurosci. 2018 Oct;66(2):229-237. doi: 10.1007/s12031-018-1159-2. Epub 2018 Aug 23. PubMed |
| The tuberous sclerosis complex subunit TBC1D7 is stabilized by Akt phosphorylation-mediated 14-3-3 binding. Madigan JP, Hou F, Ye L, Hu J, Dong A, Tempel W, Yohe ME, Randazzo PA, Jenkins LMM, Gottesman MM, Tong Y. J Biol Chem. 2018 Oct 19;293(42):16142-16159. doi: 10.1074/jbc.RA118.003525. Epub 2018 Aug 24. PubMed |
| TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging. Xu D, Jin T, Zhu H, Chen H, Ofengeim D, Zou C, Mifflin L, Pan L, Amin P, Li W, Shan B, Naito MG, Meng H, Li Y, Pan H, Aron L, Adiconis X, Levin JZ, Yankner BA, Yuan J. Cell. 2018 Sep 6;174(6):1477-1491.e19. doi: 10.1016/j.cell.2018.07.041. Epub 2018 Aug 23. PubMed |
| Phenotypic Lentivirus Screens to Identify Antiviral Single Domain Antibodies. Schmidt FI. Methods Mol Biol. 2018;1836:139-158. doi: 10.1007/978-1-4939-8678-1_7. PubMed |
| G protein pathway suppressor 2 (GPS2) links inflammation and cholesterol efflux by controlling lipopolysaccharide-induced ATP-binding cassette transporter A1 expression in macrophages. Huang Z, Liang N, Damdimopoulos A, Fan R, Treuter E. FASEB J. 2019 Feb;33(2):1631-1643. doi: 10.1096/fj.201801123R. Epub 2018 Aug 28. PubMed |
| Human tryptophanyl-tRNA synthetase is an IFN-gamma-inducible entry factor for Enterovirus. Yeung ML, Jia L, Yip CCY, Chan JFW, Teng JLL, Chan KH, Cai JP, Zhang C, Zhang AJ, Wong WM, Kok KH, Lau SKP, Woo PCY, Lo JYC, Jin DY, Shih SR, Yuen KY. J Clin Invest. 2018 Nov 1;128(11):5163-5177. doi: 10.1172/JCI99411. Epub 2018 Oct 15. PubMed |
| Modulation of motor excitability by cortical optogenetic theta burst stimulation. Wu CW, Chiu WT, Hsieh TH, Hsieh CH, Chen JJ. PLoS One. 2018 Aug 30;13(8):e0203333. doi: 10.1371/journal.pone.0203333. eCollection 2018. PubMed |
| Cancer mutations and targeted drugs can disrupt dynamic signal encoding by the Ras-Erk pathway. Bugaj LJ, Sabnis AJ, Mitchell A, Garbarino JE, Toettcher JE, Bivona TG, Lim WA. Science. 2018 Aug 31;361(6405). pii: 361/6405/eaao3048. doi: 10.1126/science.aao3048. PubMed |
| Differentiation of Human Pluripotent Stem Cells to Megakaryocytes by Transcription Factor-Driven Forward Programming. Moreau T, Evans AL, Ghevaert CJG. Methods Mol Biol. 2018;1812:155-176. doi: 10.1007/978-1-4939-8585-2_10. PubMed |
| Discovery of a small molecule targeting autophagy via ATG4B inhibition and cell death of colorectal cancer cells in vitro and in vivo. Fu Y, Hong L, Xu J, Zhong G, Gu Q, Gu Q, Guan Y, Zheng X, Dai Q, Luo X, Liu C, Huang Z, Yin XM, Liu P, Li M. Autophagy. 2019 Feb;15(2):295-311. doi: 10.1080/15548627.2018.1517073. Epub 2018 Sep 20. PubMed |
| Inhibition of TRF2 accelerates telomere attrition and DNA damage in naive CD4 T cells during HCV infection. Nguyen LN, Zhao J, Cao D, Dang X, Wang L, Lian J, Zhang Y, Jia Z, Wu XY, Morrison Z, Xie Q, Ji Y, Zhang Z, El Gazzar M, Ning S, Moorman JP, Yao ZQ. Cell Death Dis. 2018 Sep 5;9(9):900. doi: 10.1038/s41419-018-0897-y. PubMed |
| Bradykinin B2 Receptor Contributes to Inflammatory Responses in Human Endothelial Cells by the Transactivation of the Fibroblast Growth Factor Receptor FGFR-1. Terzuoli E, Corti F, Nannelli G, Giachetti A, Donnini S, Ziche M. Int J Mol Sci. 2018 Sep 6;19(9). pii: ijms19092638. doi: 10.3390/ijms19092638. PubMed |
| Lentiviral vector expression of Klf4 enhances chondrogenesis and reduces hypertrophy in equine chondrocytes. Gurusinghe S, Bandara N, Hilbert B, Trope G, Wang L, Strappe P. Gene. 2019 Jan 5;680:9-19. doi: 10.1016/j.gene.2018.09.013. Epub 2018 Sep 8. PubMed |
| USP7 and USP47 deubiquitinases regulate NLRP3 inflammasome activation. Palazon-Riquelme P, Worboys JD, Green J, Valera A, Martin-Sanchez F, Pellegrini C, Brough D, Lopez-Castejon G. EMBO Rep. 2018 Oct;19(10). pii: embr.201744766. doi: 10.15252/embr.201744766. Epub 2018 Sep 11. PubMed |
| Elevated A20 promotes TNF-induced and RIPK1-dependent intestinal epithelial cell death. Garcia-Carbonell R, Wong J, Kim JY, Close LA, Boland BS, Wong TL, Harris PA, Ho SB, Das S, Ernst PB, Sasik R, Sandborn WJ, Bertin J, Gough PJ, Chang JT, Kelliher M, Boone D, Guma M, Karin M. Proc Natl Acad Sci U S A. 2018 Sep 25;115(39):E9192-E9200. doi: 10.1073/pnas.1810584115. Epub 2018 Sep 12. PubMed |
| Identification of Novel Subcellular Localization and Trafficking of HIV-1 Nef Variants from Reference Strains G (F1.93.HH8793) and H (BE.93.VI997). Van Nynatten LR, Johnson AL, Dirk BS, Pawlak EN, Jacob RA, Haeryfar SMM, Dikeakos JD. Viruses. 2018 Sep 13;10(9). pii: v10090493. doi: 10.3390/v10090493. PubMed |
| Unbiased Genetic Screen to Identify Factors Involved in X-Chromosome Inactivation Using a Pooled Bar-Coded shRNA Library. Moindrot B, Brockdorff N. Methods Mol Biol. 2018;1861:19-36. doi: 10.1007/978-1-4939-8766-5_2. PubMed |
| Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma. McBrayer SK, Mayers JR, DiNatale GJ, Shi DD, Khanal J, Chakraborty AA, Sarosiek KA, Briggs KJ, Robbins AK, Sewastianik T, Shareef SJ, Olenchock BA, Parker SJ, Tateishi K, Spinelli JB, Islam M, Haigis MC, Looper RE, Ligon KL, Bernstein BE, Carrasco RD, Cahill DP, Asara JM, Metallo CM, Yennawar NH, Vander Heiden MG, Kaelin WG Jr. Cell. 2018 Sep 20;175(1):101-116.e25. doi: 10.1016/j.cell.2018.08.038. Epub 2018 Sep 13. PubMed |
| Upregulation of liver kinase B1 predicts poor prognosis in hepatocellular carcinoma. Tan X, Liao Z, Liang H, Chen X, Zhang B, Chu L. Int J Oncol. 2018 Nov;53(5):1913-1926. doi: 10.3892/ijo.2018.4556. Epub 2018 Sep 7. PubMed |
| Host phosphatidic acid phosphatase lipin1 is rate limiting for functional hepatitis C virus replicase complex formation. Mingorance L, Castro V, Avila-Perez G, Calvo G, Rodriguez MJ, Carrascosa JL, Perez-Del-Pulgar S, Forns X, Gastaminza P. PLoS Pathog. 2018 Sep 18;14(9):e1007284. doi: 10.1371/journal.ppat.1007284. eCollection 2018 Sep. PubMed |
| Human Sox4 facilitates the development of CXCL13-producing helper T cells in inflammatory environments. Yoshitomi H, Kobayashi S, Miyagawa-Hayashino A, Okahata A, Doi K, Nishitani K, Murata K, Ito H, Tsuruyama T, Haga H, Matsuda S, Toguchida J. Nat Commun. 2018 Sep 19;9(1):3762. doi: 10.1038/s41467-018-06187-0. PubMed |
| Promyelocytic leukemia (PML) nuclear bodies (NBs) induce latent/quiescent HSV-1 genomes chromatinization through a PML NB/Histone H3.3/H3.3 Chaperone Axis. Cohen C, Corpet A, Roubille S, Maroui MA, Poccardi N, Rousseau A, Kleijwegt C, Binda O, Texier P, Sawtell N, Labetoulle M, Lomonte P. PLoS Pathog. 2018 Sep 20;14(9):e1007313. doi: 10.1371/journal.ppat.1007313. eCollection 2018 Sep. PubMed |
| Systematic genetic mapping of necroptosis identifies SLC39A7 as modulator of death receptor trafficking. Fauster A, Rebsamen M, Willmann KL, Cesar-Razquin A, Girardi E, Bigenzahn JW, Schischlik F, Scorzoni S, Bruckner M, Konecka J, Hormann K, Heinz LX, Boztug K, Superti-Furga G. Cell Death Differ. 2018 Sep 20. pii: 10.1038/s41418-018-0192-6. doi: 10.1038/s41418-018-0192-6. PubMed |
| The microRNA-23a cluster regulates the developmental HoxA cluster function during osteoblast differentiation. Godfrey TC, Wildman BJ, Beloti MM, Kemper AG, Ferraz EP, Roy B, Rehan M, Afreen LH, Kim E, Lengner CJ, Hassan Q. J Biol Chem. 2018 Nov 9;293(45):17646-17660. doi: 10.1074/jbc.RA118.003052. Epub 2018 Sep 21. PubMed |
| Discovering human diabetes-risk gene function with genetics and physiological assays. Peiris H, Park S, Louis S, Gu X, Lam JY, Asplund O, Ippolito GC, Bottino R, Groop L, Tucker H, Kim SK. Nat Commun. 2018 Sep 21;9(1):3855. doi: 10.1038/s41467-018-06249-3. PubMed |
| Interactive Repression of MYRF Self-Cleavage and Activity in Oligodendrocyte Differentiation by TMEM98 Protein. Huang H, Teng P, Du J, Meng J, Hu X, Tang T, Zhang Z, Qi YB, Qiu M. J Neurosci. 2018 Nov 14;38(46):9829-9839. doi: 10.1523/JNEUROSCI.0154-18.2018. Epub 2018 Sep 24. PubMed |
| Acute and rapid degradation of endogenous proteins by Trim-Away. Clift D, So C, McEwan WA, James LC, Schuh M. Nat Protoc. 2018 Oct;13(10):2149-2175. doi: 10.1038/s41596-018-0028-3. PubMed |
| Growth inhibition and chemo-radiosensitization of esophageal squamous cell carcinoma by survivin-shRNA lentivirus transfection. Zhou C, Zhang L, Xu P. Oncol Lett. 2018 Oct;16(4):4813-4820. doi: 10.3892/ol.2018.9280. Epub 2018 Aug 8. PubMed |
| RNA editing derived epitopes function as cancer antigens to elicit immune responses. Zhang M, Fritsche J, Roszik J, Williams LJ, Peng X, Chiu Y, Tsou CC, Hoffgaard F, Goldfinger V, Schoor O, Talukder A, Forget MA, Haymaker C, Bernatchez C, Han L, Tsang YH, Kong K, Xu X, Scott KL, Singh-Jasuja H, Lizee G, Liang H, Weinschenk T, Mills GB, Hwu P. Nat Commun. 2018 Sep 25;9(1):3919. doi: 10.1038/s41467-018-06405-9. PubMed |
| Repression of Noxa by Bmi1 contributes to deguelin-induced apoptosis in non-small cell lung cancer cells. Li W, Yu X, Xia Z, Yu X, Xie L, Ma X, Zhou H, Liu L, Wang J, Yang Y, Liu H. J Cell Mol Med. 2018 Dec;22(12):6213-6227. doi: 10.1111/jcmm.13908. Epub 2018 Sep 25. PubMed |
| BRCA1 Mutation-Specific Responses to 53BP1 Loss-Induced Homologous Recombination and PARP Inhibitor Resistance. Nacson J, Krais JJ, Bernhardy AJ, Clausen E, Feng W, Wang Y, Nicolas E, Cai KQ, Tricarico R, Hua X, DiMarcantonio D, Martinez E, Zong D, Handorf EA, Bellacosa A, Testa JR, Nussenzweig A, Gupta GP, Sykes SM, Johnson N. Cell Rep. 2018 Sep 25;24(13):3513-3527.e7. doi: 10.1016/j.celrep.2018.08.086. PubMed |
| Anoctamin 5/TMEM16E facilitates muscle precursor cell fusion. Whitlock JM, Yu K, Cui YY, Hartzell HC. J Gen Physiol. 2018 Nov 5;150(11):1498-1509. doi: 10.1085/jgp.201812097. Epub 2018 Sep 26. PubMed |
| Fc Gamma Receptor IIb Expressed in Hepatocytes Promotes Lipid Accumulation and Gluconeogenesis. Shu T, Song X, Cui X, Ge W, Gao R, Wang J. Int J Mol Sci. 2018 Sep 26;19(10). pii: ijms19102932. doi: 10.3390/ijms19102932. PubMed |
High Fidelity Cryopreservation and Recovery of Primary Rodent Cortical Neurons.
Parker SS, Moutal A, Cai S, Chandrasekaran S, Roman MR, Koshy AA, Khanna R, Zinsmaier KE, Mouneimne G.
eNeuro. 2018 Sep 27;5(5). pii: eN-MNT-0135-18. doi: 10.1523/ENEURO.0135-18.2018. eCollection 2018 Sep-Oct.
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| Downregulation of SNCA Expression by Targeted Editing of DNA Methylation: A Potential Strategy for Precision Therapy in PD. Kantor B, Tagliafierro L, Gu J, Zamora ME, Ilich E, Grenier C, Huang ZY, Murphy S, Chiba-Falek O. Mol Ther. 2018 Nov 7;26(11):2638-2649. doi: 10.1016/j.ymthe.2018.08.019. Epub 2018 Aug 29. PubMed |
| RAB11FIP5 Expression and Altered Natural Killer Cell Function Are Associated with Induction of HIV Broadly Neutralizing Antibody Responses. Bradley T, Peppa D, Pedroza-Pacheco I, Li D, Cain DW, Henao R, Venkat V, Hora B, Chen Y, Vandergrift NA, Overman RG, Edwards RW, Woods CW, Tomaras GD, Ferrari G, Ginsburg GS, Connors M, Cohen MS, Moody MA, Borrow P, Haynes BF. Cell. 2018 Oct 4;175(2):387-399.e17. doi: 10.1016/j.cell.2018.08.064. Epub 2018 Sep 27. PubMed |
| Subversion of Systemic Glucose Metabolism as a Mechanism to Support the Growth of Leukemia Cells. Ye H, Adane B, Khan N, Alexeev E, Nusbacher N, Minhajuddin M, Stevens BM, Winters AC, Lin X, Ashton JM, Purev E, Xing L, Pollyea DA, Lozupone CA, Serkova NJ, Colgan SP, Jordan CT. Cancer Cell. 2018 Oct 8;34(4):659-673.e6. doi: 10.1016/j.ccell.2018.08.016. Epub 2018 Sep 27. PubMed |
| The DEAD-box RNA-binding protein DDX6 regulates parental RNA decay for cellular reprogramming to pluripotency. Kami D, Kitani T, Nakamura A, Wakui N, Mizutani R, Ohue M, Kametani F, Akimitsu N, Gojo S. PLoS One. 2018 Oct 1;13(10):e0203708. doi: 10.1371/journal.pone.0203708. eCollection 2018. PubMed |
| Analysis of chromatin accessibility uncovers TEAD1 as a regulator of migration in human glioblastoma. Tome-Garcia J, Erfani P, Nudelman G, Tsankov AM, Katsyv I, Tejero R, Bin Zhang, Walsh M, Friedel RH, Zaslavsky E, Tsankova NM. Nat Commun. 2018 Oct 1;9(1):4020. doi: 10.1038/s41467-018-06258-2. PubMed |
All-optical synaptic electrophysiology probes mechanism of ketamine-induced disinhibition.
Fan LZ, Nehme R, Adam Y, Jung ES, Wu H, Eggan K, Arnold DB, Cohen AE.
Nat Methods. 2018 Oct;15(10):823-831. doi: 10.1038/s41592-018-0142-8. Epub 2018 Oct 1.
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| IDH1 mutation correlates with a beneficial prognosis and suppresses tumor growth in IHCC. Wang J, Zhang ZG, Ding ZY, Dong W, Liang HF, Chu L, Zhang BX, Chen XP. J Surg Res. 2018 Nov;231:116-125. doi: 10.1016/j.jss.2018.04.056. Epub 2018 Jun 17. PubMed |
| Molecular architecture and regulation of BCL10-MALT1 filaments. Schlauderer F, Seeholzer T, Desfosses A, Gehring T, Strauss M, Hopfner KP, Gutsche I, Krappmann D, Lammens K. Nat Commun. 2018 Oct 2;9(1):4041. doi: 10.1038/s41467-018-06573-8. PubMed |
| Alpha ketoglutarate levels, regulated by p53 and OGDH, determine autophagy and cell fate/apoptosis in response to Nutlin-3a. Duan L, Perez RE, Maki CG. Cancer Biol Ther. 2019;20(3):252-260. doi: 10.1080/15384047.2018.1523858. Epub 2018 Oct 5. PubMed |
| Frequent PTEN loss and differential HER2/PI3K signaling pathway alterations in salivary duct carcinoma: Implications for targeted therapy. Saintigny P, Mitani Y, Pytynia KB, Ferrarotto R, Roberts DB, Weber RS, Kies MS, Maity SN, Lin SH, El-Naggar AK. Cancer. 2018 Sep 15;124(18):3693-3705. doi: 10.1002/cncr.31600. Epub 2018 Oct 5. PubMed |
AXL Is a Putative Tumor Suppressor and Dormancy Regulator in Prostate Cancer.
Axelrod HD, Valkenburg KC, Amend SR, Hicks JL, Parsana P, Torga G, DeMarzo AM, Pienta KJ.
Mol Cancer Res. 2019 Feb;17(2):356-369. doi: 10.1158/1541-7786.MCR-18-0718. Epub 2018 Oct 5.
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| Geometry-Dependent Arrhythmias in Electrically Excitable Tissues. McNamara HM, Dodson S, Huang YL, Miller EW, Sandstede B, Cohen AE. Cell Syst. 2018 Oct 24;7(4):359-370.e6. doi: 10.1016/j.cels.2018.08.013. Epub 2018 Oct 3. PubMed |
| Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers. Chiarella AM, Wang TA, Butler KV, Jin J, Hathaway NA. J Vis Exp. 2018 Sep 20;(139). doi: 10.3791/58222. PubMed |
MYC Interacts with the G9a Histone Methyltransferase to Drive Transcriptional Repression and Tumorigenesis.
Tu WB, Shiah YJ, Lourenco C, Mullen PJ, Dingar D, Redel C, Tamachi A, Ba-Alawi W, Aman A, Al-Awar R, Cescon DW, Haibe-Kains B, Arrowsmith CH, Raught B, Boutros PC, Penn LZ.
Cancer Cell. 2018 Oct 8;34(4):579-595.e8. doi: 10.1016/j.ccell.2018.09.001.
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| The Oncogenic Transcription Factor RUNX1/ETO Corrupts Cell Cycle Regulation to Drive Leukemic Transformation. Martinez-Soria N, McKenzie L, Draper J, Ptasinska A, Issa H, Potluri S, Blair HJ, Pickin A, Isa A, Chin PS, Tirtakusuma R, Coleman D, Nakjang S, Assi S, Forster V, Reza M, Law E, Berry P, Mueller D, Osborne C, Elder A, Bomken SN, Pal D, Allan JM, Veal GJ, Cockerill PN, Wichmann C, Vormoor J, Lacaud G, Bonifer C, Heidenreich O. Cancer Cell. 2018 Oct 8;34(4):626-642.e8. doi: 10.1016/j.ccell.2018.08.015. PubMed |
| A newly generated neuronal cell model of CLN7 disease reveals aberrant lysosome motility and impaired cell survival. von Kleist L, Ariunbat K, Braren I, Stauber T, Storch S, Danyukova T. Mol Genet Metab. 2019 Feb;126(2):196-205. doi: 10.1016/j.ymgme.2018.09.009. Epub 2018 Oct 1. PubMed |
| mTOR inhibitors lower an intrinsic barrier to virus infection mediated by IFITM3. Shi G, Ozog S, Torbett BE, Compton AA. Proc Natl Acad Sci U S A. 2018 Oct 23;115(43):E10069-E10078. doi: 10.1073/pnas.1811892115. Epub 2018 Oct 9. PubMed |
The interaction between ORF18 and ORF30 is required for late gene expression in Kaposi's sarcoma-associated herpesvirus.
Castaneda AF, Glaunsinger BA.
J Virol. 2018 Oct 10. pii: JVI.01488-18. doi: 10.1128/JVI.01488-18.
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| Increasing G9a automethylation sensitizes B acute lymphoblastic leukemia cells to glucocorticoid-induced death. Poulard C, Baulu E, Lee BH, Pufall MA, Stallcup MR. Cell Death Dis. 2018 Oct 10;9(10):1038. doi: 10.1038/s41419-018-1110-z. PubMed |
| GABAergic signaling linked to autophagy enhances host protection against intracellular bacterial infections. Kim JK, Kim YS, Lee HM, Jin HS, Neupane C, Kim S, Lee SH, Min JJ, Sasai M, Jeong JH, Choe SK, Kim JM, Yamamoto M, Choy HE, Park JB, Jo EK. Nat Commun. 2018 Oct 10;9(1):4184. doi: 10.1038/s41467-018-06487-5. PubMed |
| NRF2 transcriptionally activates the heat shock factor 1 promoter under oxidative stress and affects survival and migration potential of MCF7 cells. Paul S, Ghosh S, Mandal S, Sau S, Pal M. J Biol Chem. 2018 Dec 14;293(50):19303-19316. doi: 10.1074/jbc.RA118.003376. Epub 2018 Oct 11. PubMed |
| Lentiviral-based reporter constructs for profiling chondrogenic activity in primary equine cell populations. Martin-Pena A, Porter RM, Plumton G, McCarrel TM, Morton AJ, Guijarro MV, Ghivizzani SC, Sharma B, Palmer GD. Eur Cell Mater. 2018 Oct 12;36:156-170. doi: 10.22203/eCM.v036a12. PubMed |
| A metabolite-derived protein modification integrates glycolysis with KEAP1-NRF2 signalling. Bollong MJ, Lee G, Coukos JS, Yun H, Zambaldo C, Chang JW, Chin EN, Ahmad I, Chatterjee AK, Lairson LL, Schultz PG, Moellering RE. Nature. 2018 Oct;562(7728):600-604. doi: 10.1038/s41586-018-0622-0. Epub 2018 Oct 15. PubMed |
| Multi-stage bioengineering of a layered oesophagus with in vitro expanded muscle and epithelial adult progenitors. Urbani L, Camilli C, Phylactopoulos DE, Crowley C, Natarajan D, Scottoni F, Maghsoudlou P, McCann CJ, Pellegata AF, Urciuolo A, Deguchi K, Khalaf S, Aruta SF, Signorelli MC, Kiely D, Hannon E, Trevisan M, Wong RR, Baradez MO, Moulding D, Virasami A, Gjinovci A, Loukogeorgakis S, Mantero S, Thapar N, Sebire N, Eaton S, Lowdell M, Cossu G, Bonfanti P, De Coppi P. Nat Commun. 2018 Oct 16;9(1):4286. doi: 10.1038/s41467-018-06385-w. PubMed |
| Shear stress induces expression, intracellular reorganization and enhanced Notch activation potential of Jagged1. Driessen RCH, Stassen OMJA, Sjoqvist M, Suarez Rodriguez F, Grolleman J, Bouten CVC, Sahlgren CM. Integr Biol (Camb). 2018 Nov 12;10(11):719-726. doi: 10.1039/c8ib00036k. PubMed |
Farnesyl diphosphate synthase is important for the maintenance of glioblastoma stemness.
Kim HY, Kim DK, Bae SH, Gwak H, Jeon JH, Kim JK, Lee BI, You HJ, Shin DH, Kim YH, Kim SY, Han SS, Shim JK, Lee JH, Kang SG, Jang H.
Exp Mol Med. 2018 Oct 17;50(10):137. doi: 10.1038/s12276-018-0166-2.
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| Efficient in situ gene delivery via PEG diacrylate matrices. Shrimali P, Peter M, Singh A, Dalal N, Dakave S, Chiplunkar SV, Tayalia P. Biomater Sci. 2018 Nov 20;6(12):3241-3250. doi: 10.1039/c8bm00916c. PubMed |
| Improved dynamic monitoring of transcriptional activity during longitudinal analysis in the mouse brain. Heo H, Jo J, Jung JI, Han YM, Lee S, Kim SR, Kwon SH, Kim KN, Hwang BJ, Kee Y, Lee BD, Kang D, Her S. Biol Open. 2019 Jan 8;8(1). pii: bio.037168. doi: 10.1242/bio.037168. PubMed |
| A novel homozygous mutation in GAD1 gene described in a schizophrenic patient impairs activity and dimerization of GAD67 enzyme. Magri C, Giacopuzzi E, La Via L, Bonini D, Ravasio V, Elhussiny MEA, Orizio F, Gangemi F, Valsecchi P, Bresciani R, Barbon A, Vita A, Gennarelli M. Sci Rep. 2018 Oct 19;8(1):15470. doi: 10.1038/s41598-018-33924-8. PubMed |
| Dimerization of an aptamer generated from Ligand-guided selection (LIGS) yields a high affinity scaffold against B-cells. Batool S, Argyropoulos KV, Azad R, Okeoma P, Zumrut H, Bhandari S, Dekhang R, Mallikaratchy PR. Biochim Biophys Acta Gen Subj. 2019 Jan;1863(1):232-240. doi: 10.1016/j.bbagen.2018.10.006. Epub 2018 Oct 17. PubMed |
| A novel lysosome-to-mitochondria signaling pathway disrupted by amyloid-beta oligomers. Norambuena A, Wallrabe H, Cao R, Wang DB, Silva A, Svindrych Z, Periasamy A, Hu S, Tanzi RE, Kim DY, Bloom GS. EMBO J. 2018 Nov 15;37(22):e100241. doi: 10.15252/embj.2018100241. Epub 2018 Oct 22. PubMed |
| Monoubiquitination of ASXLs controls the deubiquitinase activity of the tumor suppressor BAP1. Daou S, Barbour H, Ahmed O, Masclef L, Baril C, Sen Nkwe N, Tchelougou D, Uriarte M, Bonneil E, Ceccarelli D, Mashtalir N, Tanji M, Masson JY, Thibault P, Sicheri F, Yang H, Carbone M, Therrien M, Affar EB. Nat Commun. 2018 Oct 22;9(1):4385. doi: 10.1038/s41467-018-06854-2. PubMed |
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| Autophagy inhibition as a potential future targeted therapy for ETV6-RUNX1-driven B-cell precursor acute lymphoblastic leukemia. Polak R, Bierings MB, van der Leije CS, Sanders MA, Roovers O, Marchante JRM, Boer JM, Cornelissen JJ, Pieters R, den Boer ML, Buitenhuis M. Haematologica. 2019 Apr;104(4):738-748. doi: 10.3324/haematol.2018.193631. Epub 2018 Oct 31. PubMed |
| p53 mutants cooperate with HIF-1 in transcriptional regulation of extracellular matrix components to promote tumor progression. Amelio I, Mancini M, Petrova V, Cairns RA, Vikhreva P, Nicolai S, Marini A, Antonov AA, Le Quesne J, Baena Acevedo JD, Dudek K, Sozzi G, Pastorino U, Knight RA, Mak TW, Melino G. Proc Natl Acad Sci U S A. 2018 Nov 13;115(46):E10869-E10878. doi: 10.1073/pnas.1808314115. Epub 2018 Oct 31. PubMed |
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| Novel flavagline-like compounds with potent Fli-1 inhibitory activity suppress diverse types of leukemia. Song J, Yuan C, Yang J, Liu T, Yao Y, Xiao X, Gajendran B, Xu D, Li YJ, Wang C, Liu W, Wen M, Spaner D, Filmus J, Zacksenhaus E, Zhang Y, Hao X, Ben-David Y. FEBS J. 2018 Dec;285(24):4631-4645. doi: 10.1111/febs.14690. Epub 2018 Nov 20. PubMed |
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| Trichomonas vaginalis Induces NLRP3 Inflammasome Activation and Pyroptotic Cell Death in Human Macrophages. Riestra AM, Valderrama JA, Patras KA, Booth SD, Quek XY, Tsai CM, Nizet V. J Innate Immun. 2019;11(1):86-98. doi: 10.1159/000493585. Epub 2018 Nov 2. PubMed |
| Polarity Acquisition in Cortical Neurons Is Driven by Synergistic Action of Sox9-Regulated Wwp1 and Wwp2 E3 Ubiquitin Ligases and Intronic miR-140. Ambrozkiewicz MC, Schwark M, Kishimoto-Suga M, Borisova E, Hori K, Salazar-Lazaro A, Rusanova A, Altas B, Piepkorn L, Bessa P, Schaub T, Zhang X, Rabe T, Ripamonti S, Rosario M, Akiyama H, Jahn O, Kobayashi T, Hoshino M, Tarabykin V, Kawabe H. Neuron. 2018 Dec 5;100(5):1097-1115.e15. doi: 10.1016/j.neuron.2018.10.008. Epub 2018 Nov 1. PubMed |
| Tumor-on-a-chip platform to investigate progression and drug sensitivity in cell lines and patient-derived organoids. Shirure VS, Bi Y, Curtis MB, Lezia A, Goedegebuure MM, Goedegebuure SP, Aft R, Fields RC, George SC. Lab Chip. 2018 Dec 7;18(23):3687-3702. doi: 10.1039/c8lc00596f. Epub 2018 Nov 5. PubMed |
| Poly(ADP-ribose) polymerase 1 is necessary for coactivating hypoxia-inducible factor-1-dependent gene expression by Epstein-Barr virus latent membrane protein 1. Hulse M, Caruso LB, Madzo J, Tan Y, Johnson S, Tempera I. PLoS Pathog. 2018 Nov 5;14(11):e1007394. doi: 10.1371/journal.ppat.1007394. eCollection 2018 Nov. PubMed |
| HEXIM1-Tat chimera inhibits HIV-1 replication. Leoz M, Kukanja P, Luo Z, Huang F, Cary DC, Peterlin BM, Fujinaga K. PLoS Pathog. 2018 Nov 5;14(11):e1007402. doi: 10.1371/journal.ppat.1007402. eCollection 2018 Nov. PubMed |
| A single-cell survey of the human first-trimester placenta and decidua. Suryawanshi H, Morozov P, Straus A, Sahasrabudhe N, Max KEA, Garzia A, Kustagi M, Tuschl T, Williams Z. Sci Adv. 2018 Oct 31;4(10):eaau4788. doi: 10.1126/sciadv.aau4788. eCollection 2018 Oct. PubMed |
| Cell-to-Cell Transmission Is the Main Mechanism Supporting Bovine Viral Diarrhea Virus Spread in Cell Culture. Merwaiss F, Czibener C, Alvarez DE. J Virol. 2019 Jan 17;93(3). pii: JVI.01776-18. doi: 10.1128/JVI.01776-18. Print 2019 Feb 1. PubMed |
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| A Human Gonadal Cell Model From Induced Pluripotent Stem Cells. Rodriguez Gutierrez D, Eid W, Biason-Lauber A. Front Genet. 2018 Oct 24;9:498. doi: 10.3389/fgene.2018.00498. eCollection 2018. PubMed |
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| A Whole-genome CRISPR Screen Identifies a Role of MSH2 in Cisplatin-mediated Cell Death in Muscle-invasive Bladder Cancer. Goodspeed A, Jean A, Costello JC. Eur Urol. 2019 Feb;75(2):242-250. doi: 10.1016/j.eururo.2018.10.040. Epub 2018 Nov 7. PubMed |
| Effective Glucose Uptake by Human Astrocytes Requires Its Sequestration in the Endoplasmic Reticulum by Glucose-6-Phosphatase-beta. Muller MS, Fouyssac M, Taylor CW. Curr Biol. 2018 Nov 5;28(21):3481-3486.e4. doi: 10.1016/j.cub.2018.08.060. Epub 2018 Oct 25. PubMed |
| LAT2 regulates glutamine-dependent mTOR activation to promote glycolysis and chemoresistance in pancreatic cancer. Feng M, Xiong G, Cao Z, Yang G, Zheng S, Qiu J, You L, Zheng L, Zhang T, Zhao Y. J Exp Clin Cancer Res. 2018 Nov 12;37(1):274. doi: 10.1186/s13046-018-0947-4. PubMed |
| Predicting Novel Therapies and Targets: Regulation of Notch3 by the Bromodomain Protein BRD4. Villar-Prados A, Wu SY, Court KA, Ma S, LaFargue C, Chowdhury MA, Engelhardt MI, Ivan C, Ram PT, Wang Y, Baggerly K, Rodriguez-Aguayo C, Lopez-Berestein G, Ming-Yang S, Maloney DJ, Yoshioka M, Strovel JW, Roszik J, Sood AK. Mol Cancer Ther. 2019 Feb;18(2):421-436. doi: 10.1158/1535-7163.MCT-18-0365. Epub 2018 Nov 12. PubMed |
| Brain injury induces HIF-1alpha-dependent transcriptional activation of LRRK2 that exacerbates brain damage. Bae YH, Joo H, Bae J, Hyeon SJ, Her S, Ko E, Choi HG, Ryu H, Hur EM, Bu Y, Lee BD. Cell Death Dis. 2018 Nov 12;9(11):1125. doi: 10.1038/s41419-018-1180-y. PubMed |
| Centrosomal protein TRIM43 restricts herpesvirus infection by regulating nuclear lamina integrity. Full F, van Gent M, Sparrer KMJ, Chiang C, Zurenski MA, Scherer M, Brockmeyer NH, Heinzerling L, Sturzl M, Korn K, Stamminger T, Ensser A, Gack MU. Nat Microbiol. 2019 Jan;4(1):164-176. doi: 10.1038/s41564-018-0285-5. Epub 2018 Nov 12. PubMed |
| The Osteogenic Niche Is a Calcium Reservoir of Bone Micrometastases and Confers Unexpected Therapeutic Vulnerability. Wang H, Tian L, Liu J, Goldstein A, Bado I, Zhang W, Arenkiel BR, Li Z, Yang M, Du S, Zhao H, Rowley DR, Wong STC, Gugala Z, Zhang XH. Cancer Cell. 2018 Nov 12;34(5):823-839.e7. doi: 10.1016/j.ccell.2018.10.002. PubMed |
| Detailed Characterization of Early HIV-1 Replication Dynamics in Primary Human Macrophages. Bejarano DA, Puertas MC, Borner K, Martinez-Picado J, Muller B, Krausslich HG. Viruses. 2018 Nov 10;10(11). pii: v10110620. doi: 10.3390/v10110620. PubMed |
| Long noncoding RNA Fer1like family member 4 suppresses hepatocellular carcinoma cell proliferation by regulating PTEN in vitro and in vivo. Sun X, Zheng G, Li C, Liu C. Mol Med Rep. 2019 Jan;19(1):685-692. doi: 10.3892/mmr.2018.9629. Epub 2018 Nov 7. PubMed |
| Sigma-2 Receptor/TMEM97 and PGRMC-1 Increase the Rate of Internalization of LDL by LDL Receptor through the Formation of a Ternary Complex. Riad A, Zeng C, Weng CC, Winters H, Xu K, Makvandi M, Metz T, Carlin S, Mach RH. Sci Rep. 2018 Nov 15;8(1):16845. doi: 10.1038/s41598-018-35430-3. PubMed |
| HDAC6 differentially regulates autophagy in stem-like versus differentiated cancer cells. Sharif T, Martell E, Dai C, Ghassemi-Rad MS, Hanes MR, Murphy PJ, Margam NN, Parmar HB, Giacomantonio CA, Duncan R, Lee PWK, Gujar S. Autophagy. 2019 Apr;15(4):686-706. doi: 10.1080/15548627.2018.1548547. Epub 2018 Dec 4. PubMed |
| MiRNA-218 regulates osteoclast differentiation and inflammation response in periodontitis rats through Mmp9. Guo J, Zeng X, Miao J, Liu C, Wei F, Liu D, Zheng Z, Ting K, Wang C, Liu Y. Cell Microbiol. 2019 Apr;21(4):e12979. doi: 10.1111/cmi.12979. Epub 2019 Jan 15. PubMed |
Mapping Cellular Reprogramming via Pooled Overexpression Screens with Paired Fitness and Single-Cell RNA-Sequencing Readout.
Parekh U, Wu Y, Zhao D, Worlikar A, Shah N, Zhang K, Mali P.
Cell Syst. 2018 Nov 12. pii: S2405-4712(18)30433-2. doi: 10.1016/j.cels.2018.10.008.
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| Genome-wide CRISPR Screens in Primary Human T Cells Reveal Key Regulators of Immune Function. Shifrut E, Carnevale J, Tobin V, Roth TL, Woo JM, Bui CT, Li PJ, Diolaiti ME, Ashworth A, Marson A. Cell. 2018 Dec 13;175(7):1958-1971.e15. doi: 10.1016/j.cell.2018.10.024. Epub 2018 Nov 15. PubMed |
| Oncogenic Amplification of Zygotic Dux Factors in Regenerating p53-Deficient Muscle Stem Cells Defines a Molecular Cancer Subtype. Preussner J, Zhong J, Sreenivasan K, Gunther S, Engleitner T, Kunne C, Glatzel M, Rad R, Looso M, Braun T, Kim J. Cell Stem Cell. 2018 Dec 6;23(6):794-805.e4. doi: 10.1016/j.stem.2018.10.011. Epub 2018 Nov 15. PubMed |
| Measurement of Force-Sensitive Protein Dynamics in Living Cells Using a Combination of Fluorescent Techniques. Rothenberg KE, Puranam I, Hoffman BD. J Vis Exp. 2018 Nov 2;(141). doi: 10.3791/58619. PubMed |
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| Peptide-based PET quantifies target engagement of PD-L1 therapeutics. Kumar D, Lisok A, Dahmane E, McCoy M, Shelake S, Chatterjee S, Allaj V, Sysa-Shah P, Wharram B, Lesniak WG, Tully E, Gabrielson E, Jaffee EM, Poirier JT, Rudin CM, Gobburu JV, Pomper MG, Nimmagadda S. J Clin Invest. 2019 Feb 1;129(2):616-630. doi: 10.1172/JCI122216. Epub 2019 Jan 7. PubMed |
| Oxidative Stress in Cells with Extra Centrosomes Drives Non-Cell-Autonomous Invasion. Arnandis T, Monteiro P, Adams SD, Bridgeman VL, Rajeeve V, Gadaleta E, Marzec J, Chelala C, Malanchi I, Cutillas PR, Godinho SA. Dev Cell. 2018 Nov 19;47(4):409-424.e9. doi: 10.1016/j.devcel.2018.10.026. PubMed |
| Vasoinhibin comprises a three-helix bundle and its antiangiogenic domain is located within the first 79 residues. Robles JP, Zamora M, Velasco-Bolom JL, Tovar M, Garduno-Juarez R, Bertsch T, Martinez de la Escalera G, Triebel J, Clapp C. Sci Rep. 2018 Nov 20;8(1):17111. doi: 10.1038/s41598-018-35383-7. PubMed |
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| Activation of miR-21-Regulated Pathways in Immune Aging Selects against Signatures Characteristic of Memory T Cells. Kim C, Hu B, Jadhav RR, Jin J, Zhang H, Cavanagh MM, Akondy RS, Ahmed R, Weyand CM, Goronzy JJ. Cell Rep. 2018 Nov 20;25(8):2148-2162.e5. doi: 10.1016/j.celrep.2018.10.074. PubMed |
| Plasminogen Activator Inhibitor-1 Promotes the Recruitment and Polarization of Macrophages in Cancer. Kubala MH, Punj V, Placencio-Hickok VR, Fang H, Fernandez GE, Sposto R, DeClerck YA. Cell Rep. 2018 Nov 20;25(8):2177-2191.e7. doi: 10.1016/j.celrep.2018.10.082. PubMed |
| Transmembrane Protease TMPRSS11B Promotes Lung Cancer Growth by Enhancing Lactate Export and Glycolytic Metabolism. Updegraff BL, Zhou X, Guo Y, Padanad MS, Chen PH, Yang C, Sudderth J, Rodriguez-Tirado C, Girard L, Minna JD, Mishra P, DeBerardinis RJ, O'Donnell KA. Cell Rep. 2018 Nov 20;25(8):2223-2233.e6. doi: 10.1016/j.celrep.2018.10.100. PubMed |
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| Hyperactivation of ERK by multiple mechanisms is toxic to RTK-RAS mutation-driven lung adenocarcinoma cells. Unni AM, Harbourne B, Oh MH, Wild S, Ferrarone JR, Lockwood WW, Varmus H. Elife. 2018 Nov 26;7. pii: 33718. doi: 10.7554/eLife.33718. PubMed |
| LncRNA Meg3 protects endothelial function by regulating the DNA damage response. Shihabudeen Haider Ali MS, Cheng X, Moran M, Haemmig S, Naldrett MJ, Alvarez S, Feinberg MW, Sun X. Nucleic Acids Res. 2018 Nov 22. pii: 5198489. doi: 10.1093/nar/gky1190. PubMed |
| Predicting the mutations generated by repair of Cas9-induced double-strand breaks. Allen F, Crepaldi L, Alsinet C, Strong AJ, Kleshchevnikov V, De Angeli P, Palenikova P, Khodak A, Kiselev V, Kosicki M, Bassett AR, Harding H, Galanty Y, Munoz-Martinez F, Metzakopian E, Jackson SP, Parts L. Nat Biotechnol. 2018 Nov 27. pii: nbt.4317. doi: 10.1038/nbt.4317. PubMed |
| PUFA-Plasmalogens Attenuate the LPS-Induced Nitric Oxide Production by Inhibiting the NF-kB, p38 MAPK and JNK Pathways in Microglial Cells. Youssef M, Ibrahim A, Akashi K, Hossain MS. Neuroscience. 2019 Jan 15;397:18-30. doi: 10.1016/j.neuroscience.2018.11.030. Epub 2018 Nov 26. PubMed |
| Cis interaction between sialylated FcgammaRIIA and the alphaI-domain of Mac-1 limits antibody-mediated neutrophil recruitment. Saggu G, Okubo K, Chen Y, Vattepu R, Tsuboi N, Rosetti F, Cullere X, Washburn N, Tahir S, Rosado AM, Holland SM, Anthony RM, Sen M, Zhu C, Mayadas TN. Nat Commun. 2018 Nov 29;9(1):5058. doi: 10.1038/s41467-018-07506-1. PubMed |
| A Combination of Visudyne and a Lipid-anchored Liposomal Formulation of Benzoporphyrin Derivative Enhances Photodynamic Therapy Efficacy in a 3D Model for Ovarian Cancer. Rizvi I, Nath S, Obaid G, Ruhi MK, Moore K, Bano S, Kessel D, Hasan T. Photochem Photobiol. 2019 Jan;95(1):419-429. doi: 10.1111/php.13066. Epub 2019 Jan 7. PubMed |
| Inflammatory Cytokine TNFalpha Promotes the Long-Term Expansion of Primary Hepatocytes in 3D Culture. Peng WC, Logan CY, Fish M, Anbarchian T, Aguisanda F, Alvarez-Varela A, Wu P, Jin Y, Zhu J, Li B, Grompe M, Wang B, Nusse R. Cell. 2018 Nov 29;175(6):1607-1619.e15. doi: 10.1016/j.cell.2018.11.012. PubMed |
| Protein Phosphatase 1 Regulatory Subunit SDS22 Inhibits Breast Cancer Cell Tumorigenesis by Functioning as a Negative Regulator of the AKT Signaling Pathway. Paul D, Bargale AB, Rapole S, Shetty PK, Santra MK. Neoplasia. 2019 Jan;21(1):30-40. doi: 10.1016/j.neo.2018.10.009. Epub 2018 Nov 27. PubMed |
| Enhancer Architecture and Essential Core Regulatory Circuitry of Chronic Lymphocytic Leukemia. Ott CJ, Federation AJ, Schwartz LS, Kasar S, Klitgaard JL, Lenci R, Li Q, Lawlor M, Fernandes SM, Souza A, Polaski D, Gadi D, Freedman ML, Brown JR, Bradner JE. Cancer Cell. 2018 Dec 10;34(6):982-995.e7. doi: 10.1016/j.ccell.2018.11.001. Epub 2018 Nov 29. PubMed |
| Fungal ligands released by innate immune effectors promote inflammasome activation during Aspergillus fumigatus infection. Briard B, Karki R, Malireddi RKS, Bhattacharya A, Place DE, Mavuluri J, Peters JL, Vogel P, Yamamoto M, Kanneganti TD. Nat Microbiol. 2019 Feb;4(2):316-327. doi: 10.1038/s41564-018-0298-0. Epub 2018 Dec 3. PubMed |
| Honey bee Royalactin unlocks conserved pluripotency pathway in mammals. Wan DC, Morgan SL, Spencley AL, Mariano N, Chang EY, Shankar G, Luo Y, Li TH, Huh D, Huynh SK, Garcia JM, Dovey CM, Lumb J, Liu L, Brown KV, Bermudez A, Luong R, Zeng H, Mascetti VL, Pitteri SJ, Wang J, Tu H, Quarta M, Sebastiano V, Nusse R, Rando TA, Carette JE, Bazan JF, Wang KC. Nat Commun. 2018 Dec 4;9(1):5078. doi: 10.1038/s41467-018-06256-4. PubMed |
| BCL10-CARD11 Fusion Mimics an Active CARD11 Seed That Triggers Constitutive BCL10 Oligomerization and Lymphocyte Activation. Seeholzer T, Kurz S, Schlauderer F, Woods S, Gehring T, Widmann S, Lammens K, Krappmann D. Front Immunol. 2018 Nov 20;9:2695. doi: 10.3389/fimmu.2018.02695. eCollection 2018. PubMed |
| Ex vivo Culture and Lentiviral Transduction of Benign Prostatic Hyperplasia (BPH) Samples. McClurg UL, McCracken SR, Butler L, Riabowol KT, Binda O. Bio Protoc. 2018 Nov 5;8(21). doi: 10.21769/BioProtoc.3075. PubMed |
| The HDAC-Associated Sin3B Protein Represses DREAM Complex Targets and Cooperates with APC/C to Promote Quiescence. Bainor AJ, Saini S, Calderon A, Casado-Polanco R, Giner-Ramirez B, Moncada C, Cantor DJ, Ernlund A, Litovchick L, David G. Cell Rep. 2018 Dec 4;25(10):2797-2807.e8. doi: 10.1016/j.celrep.2018.11.024. PubMed |
| Exome Sequencing of Drug-Resistant Clones for Target Identification. Han T, Nijhawan D. Methods Mol Biol. 2019;1888:175-187. doi: 10.1007/978-1-4939-8891-4_10. PubMed |
| A virus-packageable CRISPR screen identifies host factors mediating interferon inhibition of HIV. OhAinle M, Helms L, Vermeire J, Roesch F, Humes D, Basom R, Delrow JJ, Overbaugh J, Emerman M. Elife. 2018 Dec 6;7. pii: 39823. doi: 10.7554/eLife.39823. PubMed |
| Whole genome variant association across 100 dogs identifies a frame shift mutation in DISHEVELLED 2 which contributes to Robinow-like syndrome in Bulldogs and related screw tail dog breeds. Mansour TA, Lucot K, Konopelski SE, Dickinson PJ, Sturges BK, Vernau KL, Choi S, Stern JA, Thomasy SM, Doring S, Verstraete FJM, Johnson EG, York D, Rebhun RB, Ho HH, Brown CT, Bannasch DL. PLoS Genet. 2018 Dec 6;14(12):e1007850. doi: 10.1371/journal.pgen.1007850. eCollection 2018 Dec. PubMed |
| Interferons Transcriptionally Up-Regulate MLKL Expression in Cancer Cells. Knuth AK, Rosler S, Schenk B, Kowald L, van Wijk SJL, Fulda S. Neoplasia. 2019 Jan;21(1):74-81. doi: 10.1016/j.neo.2018.11.002. Epub 2018 Dec 3. PubMed |
| Inhibition of Inflammatory Signaling in Tet2 Mutant Preleukemic Cells Mitigates Stress-Induced Abnormalities and Clonal Hematopoiesis. Cai Z, Kotzin JJ, Ramdas B, Chen S, Nelanuthala S, Palam LR, Pandey R, Mali RS, Liu Y, Kelley MR, Sandusky G, Mohseni M, Williams A, Henao-Mejia J, Kapur R. Cell Stem Cell. 2018 Dec 6;23(6):833-849.e5. doi: 10.1016/j.stem.2018.10.013. PubMed |
| Unveiling the Role of the Most Impactful Cardiovascular Risk Locus through Haplotype Editing. Lo Sardo V, Chubukov P, Ferguson W, Kumar A, Teng EL, Duran M, Zhang L, Cost G, Engler AJ, Urnov F, Topol EJ, Torkamani A, Baldwin KK. Cell. 2018 Dec 13;175(7):1796-1810.e20. doi: 10.1016/j.cell.2018.11.014. Epub 2018 Dec 6. PubMed |
Engineering Epigenetic Regulation Using Synthetic Read-Write Modules.
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Associated Plasmids |
| Inhibition of CPAP-tubulin interaction prevents proliferation of centrosome-amplified cancer cells. Mariappan A, Soni K, Schorpp K, Zhao F, Minakar A, Zheng X, Mandad S, Macheleidt I, Ramani A, Kubelka T, Dawidowski M, Golfmann K, Wason A, Yang C, Simons J, Schmalz HG, Hyman AA, Aneja R, Ullrich R, Urlaub H, Odenthal M, Buttner R, Li H, Sattler M, Hadian K, Gopalakrishnan J. EMBO J. 2019 Jan 15;38(2). pii: embj.201899876. doi: 10.15252/embj.201899876. Epub 2018 Dec 10. PubMed |
| Binding of HMGN proteins to cell specific enhancers stabilizes cell identity. He B, Deng T, Zhu I, Furusawa T, Zhang S, Tang W, Postnikov Y, Ambs S, Li CC, Livak F, Landsman D, Bustin M. Nat Commun. 2018 Dec 7;9(1):5240. doi: 10.1038/s41467-018-07687-9. PubMed |
| Human nuclear RNAi-defective 2 (NRDE2) is an essential RNA splicing factor. Jiao AL, Perales R, Umbreit NT, Haswell JR, Piper ME, Adams BD, Pellman D, Kennedy S, Slack FJ. RNA. 2019 Mar;25(3):352-363. doi: 10.1261/rna.069773.118. Epub 2018 Dec 11. PubMed |
| Cancer Suicide Gene Therapy with TK.007. Hossain JA, Riecken K, Miletic H, Fehse B. Methods Mol Biol. 2019;1895:11-26. doi: 10.1007/978-1-4939-8922-5_2. PubMed |
| KLF4, A Gene Regulating Prostate Stem Cell Homeostasis, Is a Barrier to Malignant Progression and Predictor of Good Prognosis in Prostate Cancer. Xiong X, Schober M, Tassone E, Khodadadi-Jamayran A, Sastre-Perona A, Zhou H, Tsirigos A, Shen S, Chang M, Melamed J, Ossowski L, Wilson EL. Cell Rep. 2018 Dec 11;25(11):3006-3020.e7. doi: 10.1016/j.celrep.2018.11.065. PubMed |
| Insulin-Like Growth Factor 2 Receptor Expression Is Promoted by Human Herpesvirus 8-Encoded Interleukin-6 and Contributes to Viral Latency and Productive Replication. Li Q, Chen D, Xiang Q, Nicholas J. J Virol. 2019 Feb 19;93(5). pii: JVI.02026-18. doi: 10.1128/JVI.02026-18. Print 2019 Mar 1. PubMed |
| Mutagenesis Screens for Prostate Cancer Using Replication-Incompetent Lentiviral Vectors. Trobridge GD. Methods Mol Biol. 2019;1907:103-114. doi: 10.1007/978-1-4939-8967-6_8. PubMed |
| A20 and ABIN1 Suppression of a Keratinocyte Inflammatory Program with a Shared Single-Cell Expression Signature in Diverse Human Rashes. Harirchian P, Lee J, Hilz S, Sedgewick AJ, Perez White BE, Kesling MJ, Mully T, Golovato J, Gray M, Mauro TM, Purdom E, Kim EA, Sbitany H, Bhutani T, Vaske CJ, Benz SC, Cho RJ, Cheng JB. J Invest Dermatol. 2018 Dec 10. pii: S0022-202X(18)32924-5. doi: 10.1016/j.jid.2018.10.046. PubMed |
| Calretinin Functions in Malignant Mesothelioma Cells Cannot Be Replaced by the Closely Related Ca(2+)-Binding Proteins Calbindin-D28k and Parvalbumin. Worthmuller J, Oberson A, Salicio V, Blum W, Schwaller B. Int J Mol Sci. 2018 Dec 12;19(12). pii: ijms19124015. doi: 10.3390/ijms19124015. PubMed |
| New neurons use Slit-Robo signaling to migrate through the glial meshwork and approach a lesion for functional regeneration. Kaneko N, Herranz-Perez V, Otsuka T, Sano H, Ohno N, Omata T, Nguyen HB, Thai TQ, Nambu A, Kawaguchi Y, Garcia-Verdugo JM, Sawamoto K. Sci Adv. 2018 Dec 12;4(12):eaav0618. doi: 10.1126/sciadv.aav0618. eCollection 2018 Dec. PubMed |
| The histone chaperone complex FACT promotes proliferative switch of G0 cancer cells. Bi L, Xie C, Yao M, Thae Hnit SS, Vignarajan S, Wang Y, Wang Q, Xi Z, Xu H, Li Z, de Souza P, Tee A, Wong M, Liu T, Zhao X, Zhou J, Xu L, Dong Q. Int J Cancer. 2018 Dec 13. doi: 10.1002/ijc.32065. PubMed |
| Toll-like receptor chaperone HSP90B1 and the immune response to Mycobacteria. Graustein AD, Misch EA, Musvosvi M, Shey M, Shah JA, Seshadri C, Aguoju A, Bowman K, Mulenga H, Veldsman A, Hanekom WA, Hatherill M, Scriba TJ, Hawn TR. PLoS One. 2018 Dec 14;13(12):e0208940. doi: 10.1371/journal.pone.0208940. eCollection 2018. PubMed |
| Simultaneous Loss of Both Atypical Protein Kinase C Genes in the Intestinal Epithelium Drives Serrated Intestinal Cancer by Impairing Immunosurveillance. Nakanishi Y, Duran A, L'Hermitte A, Shelton PM, Nakanishi N, Reina-Campos M, Huang J, Soldevila F, Baaten BJG, Tauriello DVF, Castilla EA, Bhangoo MS, Bao F, Sigal D, Diaz-Meco MT, Moscat J. Immunity. 2018 Dec 18;49(6):1132-1147.e7. doi: 10.1016/j.immuni.2018.09.013. Epub 2018 Dec 11. PubMed |
| APOPT1/COA8 assists COX assembly and is oppositely regulated by UPS and ROS. Signes A, Cerutti R, Dickson AS, Beninca C, Hinchy EC, Ghezzi D, Carrozzo R, Bertini E, Murphy MP, Nathan JA, Viscomi C, Fernandez-Vizarra E, Zeviani M. EMBO Mol Med. 2019 Jan;11(1). pii: emmm.201809582. doi: 10.15252/emmm.201809582. PubMed |
| Clathrin-Mediated Endocytosis Regulates a Balance between Opposing Signals to Maintain the Pluripotent State of Embryonic Stem Cells. Narayana YV, Gadgil C, Mote RD, Rajan R, Subramanyam D. Stem Cell Reports. 2019 Jan 8;12(1):152-164. doi: 10.1016/j.stemcr.2018.11.018. Epub 2018 Dec 13. PubMed |
| Layer-by-layer assembled gold nanoshells for the intracellular delivery of miR-34a. Goyal R, Kapadia CH, Melamed JR, Riley RS, Day ES. Cell Mol Bioeng. 2018 Oct;11(5):383-396. doi: 10.1007/s12195-018-0535-x. Epub 2018 Jun 6. PubMed |
| Calretinin promotes invasiveness and EMT in malignant mesothelioma cells involving the activation of the FAK signaling pathway. Worthmuller J, Blum W, Pecze L, Salicio V, Schwaller B. Oncotarget. 2018 Nov 20;9(91):36256-36272. doi: 10.18632/oncotarget.26332. eCollection 2018 Nov 20. PubMed |
| FAM134B induces tumorigenesis and epithelial-to-mesenchymal transition via Akt signaling in hepatocellular carcinoma. Zhang ZQ, Chen J, Huang WQ, Ning D, Liu QM, Wang C, Zhang L, Ren L, Chu L, Liang HF, Fan HN, Zhang BX, Chen XP. Mol Oncol. 2019 Apr;13(4):792-810. doi: 10.1002/1878-0261.12429. Epub 2019 Jan 24. PubMed |
| Prostate transmembrane protein androgen induced 1 is induced by activation of osteoclasts and regulates bone resorption. Xu X, Hirata H, Shiraki M, Kamohara A, Nishioka K, Miyamoto H, Kukita T, Kukita A. FASEB J. 2019 Mar;33(3):4365-4375. doi: 10.1096/fj.201801573R. Epub 2018 Dec 17. PubMed |
Multiplexed orthogonal genome editing and transcriptional activation by Cas12a.
Breinig M, Schweitzer AY, Herianto AM, Revia S, Schaefer L, Wendler L, Cobos Galvez A, Tschaharganeh DF.
Nat Methods. 2019 Jan;16(1):51-54. doi: 10.1038/s41592-018-0262-1. Epub 2018 Dec 17.
PubMed
Associated Plasmids |
| Invasion of white matter tracts by glioma stem cells is regulated by a NOTCH1-SOX2 positive-feedback loop. Wang J, Xu SL, Duan JJ, Yi L, Guo YF, Shi Y, Li L, Yang ZY, Liao XM, Cai J, Zhang YQ, Xiao HL, Yin L, Wu H, Zhang JN, Lv SQ, Yang QK, Yang XJ, Jiang T, Zhang X, Bian XW, Yu SC. Nat Neurosci. 2019 Jan;22(1):91-105. doi: 10.1038/s41593-018-0285-z. Epub 2018 Dec 17. PubMed |
| A protein-protein interaction map of the TNF-induced NF-kappaB signal transduction pathway. Van Quickelberghe E, De Sutter D, van Loo G, Eyckerman S, Gevaert K. Sci Data. 2018 Dec 18;5:180289. doi: 10.1038/sdata.2018.289. PubMed |
| CRISPR-Mediated Approaches to Regulate YAP/TAZ Levels. Quinton RJ, Ganem NJ. Methods Mol Biol. 2019;1893:203-214. doi: 10.1007/978-1-4939-8910-2_16. PubMed |
| CCNG1 (Cyclin G1) regulation by mutant-P53 via induction of Notch3 expression promotes high-grade serous ovarian cancer (HGSOC) tumorigenesis and progression. Xu Y, Zhang Q, Miao C, Dongol S, Li Y, Jin C, Dong R, Li Y, Yang X, Kong B. Cancer Med. 2019 Jan;8(1):351-362. doi: 10.1002/cam4.1812. Epub 2018 Dec 18. PubMed |
| RNA interference screen identifies NAA10 as a regulator of PXR transcription. Oladimeji PO, Wright WC, Wu J, Chen T. Biochem Pharmacol. 2019 Feb;160:92-109. doi: 10.1016/j.bcp.2018.12.012. Epub 2018 Dec 16. PubMed |
| High PLK4 expression promotes tumor progression and induces epithelialmesenchymal transition by regulating the Wnt/betacatenin signaling pathway in colorectal cancer. Liao Z, Zhang H, Fan P, Huang Q, Dong K, Qi Y, Song J, Chen L, Liang H, Chen X, Zhang Z, Zhang B. Int J Oncol. 2019 Feb;54(2):479-490. doi: 10.3892/ijo.2018.4659. Epub 2018 Dec 10. PubMed |
| An amphipathic helix of vinexin alpha is necessary for a substrate stiffness-dependent conformational change in vinculin. Hino N, Ichikawa T, Kimura Y, Matsuda M, Ueda K, Kioka N. J Cell Sci. 2019 Jan 21;132(2). pii: jcs.217349. doi: 10.1242/jcs.217349. PubMed |
| Identification of Embryonic Neural Plate Border Stem Cells and Their Generation by Direct Reprogramming from Adult Human Blood Cells. Thier MC, Hommerding O, Panten J, Pinna R, Garcia-Gonzalez D, Berger T, Worsdorfer P, Assenov Y, Scognamiglio R, Przybylla A, Kaschutnig P, Becker L, Milsom MD, Jauch A, Utikal J, Herrmann C, Monyer H, Edenhofer F, Trumpp A. Cell Stem Cell. 2019 Jan 3;24(1):166-182.e13. doi: 10.1016/j.stem.2018.11.015. Epub 2018 Dec 20. PubMed |
| Genome-wide CRISPR Analysis Identifies Substrate-Specific Conjugation Modules in ER-Associated Degradation. Leto DE, Morgens DW, Zhang L, Walczak CP, Elias JE, Bassik MC, Kopito RR. Mol Cell. 2019 Jan 17;73(2):377-389.e11. doi: 10.1016/j.molcel.2018.11.015. Epub 2018 Dec 20. PubMed |
A Compact, High-Accuracy Cas9 with a Dinucleotide PAM for In Vivo Genome Editing.
Edraki A, Mir A, Ibraheim R, Gainetdinov I, Yoon Y, Song CQ, Cao Y, Gallant J, Xue W, Rivera-Perez JA, Sontheimer EJ.
Mol Cell. 2018 Dec 18. pii: S1097-2765(18)31033-5. doi: 10.1016/j.molcel.2018.12.003.
PubMed
Associated Plasmids |
| Inhibition of Dipeptidyl Peptidase-4 Accelerates Epithelial-Mesenchymal Transition and Breast Cancer Metastasis via the CXCL12/CXCR4/mTOR Axis. Yang F, Takagaki Y, Yoshitomi Y, Ikeda T, Li J, Kitada M, Kumagai A, Kawakita E, Shi S, Kanasaki K, Koya D. Cancer Res. 2019 Feb 15;79(4):735-746. doi: 10.1158/0008-5472.CAN-18-0620. Epub 2018 Dec 24. PubMed |
| Anti-Human Rhinovirus 1B Activity of Dexamethasone viaGCR-Dependent Autophagy Activation. Lee JS, Kim SR, Song JH, Lee YP, Ko HJ. Osong Public Health Res Perspect. 2018 Dec;9(6):334-339. doi: 10.24171/j.phrp.2018.9.6.07. PubMed |
| Identification of Novel Protein Targets of Dimethyl Fumarate Modification in Neurons and Astrocytes Reveals Actions Independent of Nrf2 Stabilization. Piroli GG, Manuel AM, Patel T, Walla MD, Shi L, Lanci SA, Wang J, Galloway A, Ortinski PI, Smith DS, Frizzell N. Mol Cell Proteomics. 2019 Mar;18(3):504-519. doi: 10.1074/mcp.RA118.000922. Epub 2018 Dec 26. PubMed |
| Dual Mechanisms of LYN Kinase Dysregulation Drive Aggressive Behavior in Breast Cancer Cells. Tornillo G, Knowlson C, Kendrick H, Cooke J, Mirza H, Aurrekoetxea-Rodriguez I, Vivanco MDM, Buckley NE, Grigoriadis A, Smalley MJ. Cell Rep. 2018 Dec 26;25(13):3674-3692.e10. doi: 10.1016/j.celrep.2018.11.103. PubMed |
| Sensitive ADAR editing reporter in cancer cells enables high-throughput screening of small molecule libraries. Fritzell K, Xu LD, Otrocka M, Andreasson C, Ohman M. Nucleic Acids Res. 2019 Feb 28;47(4):e22. doi: 10.1093/nar/gky1228. PubMed |
Creation of versatile cloning platforms for transgene expression and dCas9-based epigenome editing.
Haldeman JM, Conway AE, Arlotto ME, Slentz DH, Muoio DM, Becker TC, Newgard CB.
Nucleic Acids Res. 2018 Dec 27. pii: 5264291. doi: 10.1093/nar/gky1286.
PubMed
Associated Plasmids |
Alternative 3' UTRs direct localization of functionally diverse protein isoforms in neuronal compartments.
Ciolli Mattioli C, Rom A, Franke V, Imami K, Arrey G, Terne M, Woehler A, Akalin A, Ulitsky I, Chekulaeva M.
Nucleic Acids Res. 2018 Dec 22. pii: 5258023. doi: 10.1093/nar/gky1270.
PubMed
Associated Plasmids |
| Overcoming Challenges of Hepatitis C Virus Envelope Glycoprotein Production in Mammalian Cells. Yost SA, Whidby J, Khan AG, Wang Y, Marcotrigiano J. Methods Mol Biol. 2019;1911:305-316. doi: 10.1007/978-1-4939-8976-8_21. PubMed |
| Proteolytic cleavage of Beclin 1 exacerbates neurodegeneration. Bieri G, Lucin KM, O'Brien CE, Zhang H, Villeda SA, Wyss-Coray T. Mol Neurodegener. 2018 Dec 29;13(1):68. doi: 10.1186/s13024-018-0302-4. PubMed |
| Common ELF1 deletion in prostate cancer bolsters oncogenic ETS function, inhibits senescence and promotes docetaxel resistance. Budka JA, Ferris MW, Capone MJ, Hollenhorst PC. Genes Cancer. 2018 May;9(5-6):198-214. doi: 10.18632/genesandcancer.182. PubMed |
| SG formation relies on eIF4GI-G3BP interaction which is targeted by picornavirus stress antagonists. Yang X, Hu Z, Zhang Q, Fan S, Zhong Y, Guo D, Qin Y, Chen M. Cell Discov. 2019 Jan 1;5:1. doi: 10.1038/s41421-018-0068-4. eCollection 2019. PubMed |
| CD46 Null Packaging Cell Line Improves Measles Lentiviral Vector Production and Gene Delivery to Hematopoietic Stem and Progenitor Cells. Ozog S, Chen CX, Simpson E, Garijo O, Timberlake ND, Minder P, Verhoeyen E, Torbett BE. Mol Ther Methods Clin Dev. 2018 Nov 24;13:27-39. doi: 10.1016/j.omtm.2018.11.006. eCollection 2019 Jun 14. PubMed |
| DHHC4 and DHHC5 Facilitate Fatty Acid Uptake by Palmitoylating and Targeting CD36 to the Plasma Membrane. Wang J, Hao JW, Wang X, Guo H, Sun HH, Lai XY, Liu LY, Zhu M, Wang HY, Li YF, Yu LY, Xie C, Wang HR, Mo W, Zhou HM, Chen S, Liang G, Zhao TJ. Cell Rep. 2019 Jan 2;26(1):209-221.e5. doi: 10.1016/j.celrep.2018.12.022. PubMed |
| SHP2 Drives Adaptive Resistance to ERK Signaling Inhibition in Molecularly Defined Subsets of ERK-Dependent Tumors. Ahmed TA, Adamopoulos C, Karoulia Z, Wu X, Sachidanandam R, Aaronson SA, Poulikakos PI. Cell Rep. 2019 Jan 2;26(1):65-78.e5. doi: 10.1016/j.celrep.2018.12.013. PubMed |
| UBQLN4 Represses Homologous Recombination and Is Overexpressed in Aggressive Tumors. Jachimowicz RD, Beleggia F, Isensee J, Velpula BB, Goergens J, Bustos MA, Doll MA, Shenoy A, Checa-Rodriguez C, Wiederstein JL, Baranes-Bachar K, Bartenhagen C, Hertwig F, Teper N, Nishi T, Schmitt A, Distelmaier F, Ludecke HJ, Albrecht B, Kruger M, Schumacher B, Geiger T, Hoon DSB, Huertas P, Fischer M, Hucho T, Peifer M, Ziv Y, Reinhardt HC, Wieczorek D, Shiloh Y. Cell. 2019 Jan 24;176(3):505-519.e22. doi: 10.1016/j.cell.2018.11.024. Epub 2019 Jan 3. PubMed |
| METTL13 Methylation of eEF1A Increases Translational Output to Promote Tumorigenesis. Liu S, Hausmann S, Carlson SM, Fuentes ME, Francis JW, Pillai R, Lofgren SM, Hulea L, Tandoc K, Lu J, Li A, Nguyen ND, Caporicci M, Kim MP, Maitra A, Wang H, Wistuba II, Porco JA Jr, Bassik MC, Elias JE, Song J, Topisirovic I, Van Rechem C, Mazur PK, Gozani O. Cell. 2019 Jan 24;176(3):491-504.e21. doi: 10.1016/j.cell.2018.11.038. Epub 2019 Jan 3. PubMed |
| Chemically induced vesiculation as a platform for studying TMEM16F activity. Han TW, Ye W, Bethel NP, Zubia M, Kim A, Li KH, Burlingame AL, Grabe M, Jan YN, Jan LY. Proc Natl Acad Sci U S A. 2019 Jan 22;116(4):1309-1318. doi: 10.1073/pnas.1817498116. Epub 2019 Jan 8. PubMed |
| Intratumoral expression using a NFkB-based promoter enhances IL12 antitumor efficacy. Garaulet G, Perez-Chacon G, Alarcon H, Alfranca A, Mulero F, Martinez-Torrecuadrada J, Zapata JM, Rodriguez A. Cancer Gene Ther. 2019 Jan 9. pii: 10.1038/s41417-018-0076-4. doi: 10.1038/s41417-018-0076-4. PubMed |
| Targeting JNK pathway promotes human hematopoietic stem cell expansion. Xiao X, Lai W, Xie H, Liu Y, Guo W, Liu Y, Li Y, Li Y, Zhang J, Chen W, Shi M, Shang L, Yin M, Wang C, Deng H. Cell Discov. 2019 Jan 8;5:2. doi: 10.1038/s41421-018-0072-8. eCollection 2019. PubMed |
| An efficient method for the transduction of primary pediatric glioma neurospheres. Meel MH, Metselaar DS, Waranecki P, Kaspers GJL, Hulleman E. MethodsX. 2018 Feb 27;5:173-183. doi: 10.1016/j.mex.2018.02.006. eCollection 2018. PubMed |
| Development of a Novel Anti-CD19 Chimeric Antigen Receptor: A Paradigm for an Affordable CAR T Cell Production at Academic Institutions. Castella M, Boronat A, Martin-Ibanez R, Rodriguez V, Sune G, Caballero M, Marzal B, Perez-Amill L, Martin-Antonio B, Castano J, Bueno C, Balague O, Gonzalez-Navarro EA, Serra-Pages C, Engel P, Vilella R, Benitez-Ribas D, Ortiz-Maldonado V, Cid J, Tabera J, Canals JM, Lozano M, Baumann T, Vilarrodona A, Trias E, Campo E, Menendez P, Urbano-Ispizua A, Yague J, Perez-Galan P, Rives S, Delgado J, Juan M. Mol Ther Methods Clin Dev. 2018 Dec 6;12:134-144. doi: 10.1016/j.omtm.2018.11.010. eCollection 2019 Mar 15. PubMed |
| Multicolour In Vivo Bioluminescence Imaging Using a NanoLuc-Based BRET Reporter in Combination with Firefly Luciferase. Taylor A, Sharkey J, Plagge A, Wilm B, Murray P. Contrast Media Mol Imaging. 2018 Dec 3;2018:2514796. doi: 10.1155/2018/2514796. eCollection 2018. PubMed |
| Genome-wide analysis of ETV1 targets: Insights into the role of ETV1 in tumor progression. Eid W, Abdel-Rehim W. J Cell Biochem. 2019 Jan 10. doi: 10.1002/jcb.28169. PubMed |
| Enhancer Domains in Gastrointestinal Stromal Tumor Regulate KIT Expression and Are Targetable by BET Bromodomain Inhibition. Hemming ML, Lawlor MA, Andersen JL, Hagan T, Chipashvili O, Scott TG, Raut CP, Sicinska E, Armstrong SA, Demetri GD, Bradner JE. Cancer Res. 2019 Mar 1;79(5):994-1009. doi: 10.1158/0008-5472.CAN-18-1888. Epub 2019 Jan 10. PubMed |
CRISPR-Cas9 Circular Permutants as Programmable Scaffolds for Genome Modification.
Oakes BL, Fellmann C, Rishi H, Taylor KL, Ren SM, Nadler DC, Yokoo R, Arkin AP, Doudna JA, Savage DF.
Cell. 2019 Jan 10;176(1-2):254-267.e16. doi: 10.1016/j.cell.2018.11.052.
PubMed
Associated Plasmids |
| Establishment and characterization of an immortalized renal cell line of the Chinese tree shrew (Tupaia belangeri chinesis). Gu T, Yu D, Li Y, Xu L, Yao YL, Yao YG. Appl Microbiol Biotechnol. 2019 Mar;103(5):2171-2180. doi: 10.1007/s00253-019-09615-3. Epub 2019 Jan 12. PubMed |
| TIPE3 is a regulator of cell apoptosis in glioblastoma. Yuan F, Liu B, Xu Y, Li Y, Sun Q, Xu P, Geng R, Den G, Yang J, Zhang S, Gao L, Liao J, Liu J, Yang X, Tan Y, Chen Q. Cancer Lett. 2019 Apr 1;446:1-14. doi: 10.1016/j.canlet.2018.12.019. Epub 2019 Jan 11. PubMed |
| Generation of porcine induced-pluripotent stem cells from Sertoli cells. Setthawong P, Phakdeedindan P, Tiptanavattana N, Rungarunlert S, Techakumphu M, Tharasanit T. Theriogenology. 2019 Mar 15;127:32-40. doi: 10.1016/j.theriogenology.2018.12.033. Epub 2018 Dec 21. PubMed |
| IL-1beta Inflammatory Cytokine-Induced TP63 Isoform NP63alpha Signaling Cascade Contributes to Cisplatin Resistance in Human Breast Cancer Cells. Mendoza-Rodriguez MG, Ayala-Sumuano JT, Garcia-Morales L, Zamudio-Meza H, Perez-Yepez EA, Meza I. Int J Mol Sci. 2019 Jan 11;20(2). pii: ijms20020270. doi: 10.3390/ijms20020270. PubMed |
| Non-Invasive Longitudinal Bioluminescence Imaging of Human Mesoangioblasts in Bioengineered Esophagi. Crowley C, Butler CR, Camilli C, Hynds RE, Kolluri KK, Janes SM, De Coppi P, Urbani L. Tissue Eng Part C Methods. 2019 Feb;25(2):103-113. doi: 10.1089/ten.TEC.2018.0351. PubMed |
| Requirement for PRC1 subunit BMI1 in host gene activation by Epstein-Barr virus protein EBNA3C. Paschos K, Bazot Q, Lees J, Farrell PJ, Allday MJ. Nucleic Acids Res. 2019 Jan 15. pii: 5289486. doi: 10.1093/nar/gky1323. PubMed |
| Fever Promotes T Lymphocyte Trafficking via a Thermal Sensory Pathway Involving Heat Shock Protein 90 and alpha4 Integrins. Lin C, Zhang Y, Zhang K, Zheng Y, Lu L, Chang H, Yang H, Yang Y, Wan Y, Wang S, Yuan M, Yan Z, Zhang R, He Y, Ge G, Wu D, Chen J. Immunity. 2019 Jan 15;50(1):137-151.e6. doi: 10.1016/j.immuni.2018.11.013. PubMed |
| TRIM28 promotes HIV-1 latency by SUMOylating CDK9 and inhibiting P-TEFb. Ma X, Yang T, Luo Y, Wu L, Jiang Y, Song Z, Pan T, Liu B, Liu G, Liu J, Yu F, He Z, Zhang W, Yang J, Liang L, Guan Y, Zhang X, Li L, Cai W, Tang X, Gao S, Deng K, Zhang H. Elife. 2019 Jan 17;8. pii: 42426. doi: 10.7554/eLife.42426. PubMed |
| Activating PTEN Tumor Suppressor Expression with the CRISPR/dCas9 System. Moses C, Nugent F, Waryah CB, Garcia-Bloj B, Harvey AR, Blancafort P. Mol Ther Nucleic Acids. 2019 Mar 1;14:287-300. doi: 10.1016/j.omtn.2018.12.003. Epub 2018 Dec 14. PubMed |
| Myosin IIB assembly state determines its mechanosensitive dynamics. Schiffhauer ES, Ren Y, Iglesias VA, Kothari P, Iglesias PA, Robinson DN. J Cell Biol. 2019 Mar 4;218(3):895-908. doi: 10.1083/jcb.201806058. Epub 2019 Jan 17. PubMed |
| Epigenomic profiling of myelofibrosis reveals widespread DNA methylation changes in enhancer elements and ZFP36L1 as a potential tumor suppressor gene that is epigenetically regulated. Martinez-Calle N, Pascual M, Ordonez R, Eneriz ESJ, Kulis M, Miranda E, Guruceaga E, Segura V, Larrayoz MJ, Bellosillo B, Calasanz MJ, Besses C, Rifon J, Martin-Subero JI, Agirre X, Prosper F. Haematologica. 2019 Aug;104(8):1572-1579. doi: 10.3324/haematol.2018.204917. Epub 2019 Jan 17. PubMed |
| The circadian E3 ligase complex SCF(FBXL3+CRY) targets TLK2. Correia SP, Chan AB, Vaughan M, Zolboot N, Perea V, Huber AL, Kriebs A, Moresco JJ, Yates JR 3rd, Lamia KA. Sci Rep. 2019 Jan 17;9(1):198. doi: 10.1038/s41598-018-36618-3. PubMed |
| circRNA of AR-suppressed PABPC1 91 bp enhances the cytotoxicity of natural killer cells against hepatocellular carcinoma via upregulating UL16 binding protein 1. Ma Y, Zhang C, Zhang B, Yu H, Yu Q. Oncol Lett. 2019 Jan;17(1):388-397. doi: 10.3892/ol.2018.9606. Epub 2018 Oct 22. PubMed |
| Soluble CD93 is an apoptotic cell opsonin recognized by alphax beta2. Blackburn JWD, Lau DHC, Liu EY, Ellins J, Vrieze AM, Pawlak EN, Dikeakos JD, Heit B. Eur J Immunol. 2019 Apr;49(4):600-610. doi: 10.1002/eji.201847801. Epub 2019 Feb 7. PubMed |
Redundancy of human ATG4 protease isoforms in autophagy and LC3/GABARAP processing revealed in cells.
Agrotis A, Pengo N, Burden JJ, Ketteler R.
Autophagy. 2019 Jan 21. doi: 10.1080/15548627.2019.1569925.
PubMed
Associated Plasmids |
| FOXO3-Engineered Human ESC-Derived Vascular Cells Promote Vascular Protection and Regeneration. Yan P, Li Q, Wang L, Lu P, Suzuki K, Liu Z, Lei J, Li W, He X, Wang S, Ding J, Chan P, Zhang W, Song M, Izpisua Belmonte JC, Qu J, Tang F, Liu GH. Cell Stem Cell. 2019 Mar 7;24(3):447-461.e8. doi: 10.1016/j.stem.2018.12.002. Epub 2019 Jan 17. PubMed |
| Direct in vivo application of induced pluripotent stem cells is feasible and can be safe. Xiang M, Lu M, Quan J, Xu M, Meng D, Cui A, Li N, Liu Y, Lu P, Kang X, Wang X, Sun N, Zhao M, Liang Q, Le L, Wang X, Zhang J, Chen S. Theranostics. 2019 Jan 1;9(1):290-310. doi: 10.7150/thno.28671. eCollection 2019. PubMed |
| The PI3K/AKT signaling pathway regulates ABCG2 expression and confers resistance to chemotherapy in human multiple myeloma. Wang L, Lin N, Li Y. Oncol Rep. 2019 Mar;41(3):1678-1690. doi: 10.3892/or.2019.6968. Epub 2019 Jan 11. PubMed |
A genetically encoded near-infrared fluorescent calcium ion indicator.
Qian Y, Piatkevich KD, Mc Larney B, Abdelfattah AS, Mehta S, Murdock MH, Gottschalk S, Molina RS, Zhang W, Chen Y, Wu J, Drobizhev M, Hughes TE, Zhang J, Schreiter ER, Shoham S, Razansky D, Boyden ES, Campbell RE.
Nat Methods. 2019 Feb;16(2):171-174. doi: 10.1038/s41592-018-0294-6. Epub 2019 Jan 21.
PubMed
Associated Plasmids |
| The lysine-specific methyltransferase KMT2C/MLL3 regulates DNA repair components in cancer. Rampias T, Karagiannis D, Avgeris M, Polyzos A, Kokkalis A, Kanaki Z, Kousidou E, Tzetis M, Kanavakis E, Stravodimos K, Manola KN, Pantelias GE, Scorilas A, Klinakis A. EMBO Rep. 2019 Mar;20(3). pii: embr.201846821. doi: 10.15252/embr.201846821. Epub 2019 Jan 21. PubMed |
| MBD3/NuRD loss participates with KDM6A program to promote DOCK5/8 expression and Rac GTPase activation in human acute myeloid leukemia. Biswas M, Chatterjee SS, Boila LD, Chakraborty S, Banerjee D, Sengupta A. FASEB J. 2019 Apr;33(4):5268-5286. doi: 10.1096/fj.201801035R. Epub 2019 Jan 22. PubMed |
| HDAC1 and HDAC2 Double Knockout Triggers Cell Apoptosis in Advanced Thyroid Cancer. Lin CL, Tsai ML, Lin CY, Hsu KW, Hsieh WS, Chi WM, Huang LC, Lee CH. Int J Mol Sci. 2019 Jan 21;20(2). pii: ijms20020454. doi: 10.3390/ijms20020454. PubMed |
| Long non-coding RNA PSMB8-AS1 regulates influenza virus replication. More S, Zhu Z, Lin K, Huang C, Pushparaj S, Liang Y, Sathiaseelan R, Yang X, Liu L. RNA Biol. 2019 Mar;16(3):340-353. doi: 10.1080/15476286.2019.1572448. Epub 2019 Jan 28. PubMed |
| Endothelial-specific deletion of Ets-1 attenuates Angiotensin II-induced cardiac fibrosis via suppression of endothelial-to-mesenchymal transition. Xu L, Fu M, Chen D, Han W, Ostrowski MC, Grossfeld P, Gao P, Ye M. BMB Rep. 2019 Oct;52(10):595-600. PubMed |
| Phosphoglycolate has profound metabolic effects but most likely no role in a metabolic DNA response in cancer cell lines. Gerin I, Bury M, Baldin F, Graff J, Van Schaftingen E, Bommer GT. Biochem J. 2019 Feb 19;476(4):629-643. doi: 10.1042/BCJ20180435. PubMed |
| HIV-1 nuclear import in macrophages is regulated by CPSF6-capsid interactions at the nuclear pore complex. Bejarano DA, Peng K, Laketa V, Borner K, Jost KL, Lucic B, Glass B, Lusic M, Muller B, Krausslich HG. Elife. 2019 Jan 23;8. pii: 41800. doi: 10.7554/eLife.41800. PubMed |
| Longitudinal Visualization of Viable Cancer Cell Intratumoral Distribution in Mouse Models Using Oatp1a1-Enhanced Magnetic Resonance Imaging. Nystrom NN, Hamilton AM, Xia W, Liu S, Scholl TJ, Ronald JA. Invest Radiol. 2019 May;54(5):302-311. doi: 10.1097/RLI.0000000000000542. PubMed |
| Gain-of-Function Mutations of SLC16A11 Contribute to the Pathogenesis of Type 2 Diabetes. Zhao Y, Feng Z, Zhang Y, Sun Y, Chen Y, Liu X, Li S, Zhou T, Chen L, Wei Y, Ma D, Lui KO, Ying H, Chen Y, Ding Q. Cell Rep. 2019 Jan 22;26(4):884-892.e4. doi: 10.1016/j.celrep.2018.12.100. PubMed |
| Neuron-Specific Gene 2 (NSG2) Encodes an AMPA Receptor Interacting Protein That Modulates Excitatory Neurotransmission. Chander P, Kennedy MJ, Winckler B, Weick JP. eNeuro. 2019 Jan 24;6(1). pii: eN-NWR-0292-18. doi: 10.1523/ENEURO.0292-18.2018. eCollection 2019 Jan-Feb. PubMed |
| Role of heparan sulfate in the Zika virus entry, replication, and cell death. Gao H, Lin Y, He J, Zhou S, Liang M, Huang C, Li X, Liu C, Zhang P. Virology. 2019 Mar;529:91-100. doi: 10.1016/j.virol.2019.01.019. Epub 2019 Jan 18. PubMed |
| Exogenous Monounsaturated Fatty Acids Promote a Ferroptosis-Resistant Cell State. Magtanong L, Ko PJ, To M, Cao JY, Forcina GC, Tarangelo A, Ward CC, Cho K, Patti GJ, Nomura DK, Olzmann JA, Dixon SJ. Cell Chem Biol. 2019 Mar 21;26(3):420-432.e9. doi: 10.1016/j.chembiol.2018.11.016. Epub 2019 Jan 24. PubMed |
| Targeting the Vulnerability of Glutathione Metabolism in ARID1A-Deficient Cancers. Ogiwara H, Takahashi K, Sasaki M, Kuroda T, Yoshida H, Watanabe R, Maruyama A, Makinoshima H, Chiwaki F, Sasaki H, Kato T, Okamoto A, Kohno T. Cancer Cell. 2019 Feb 11;35(2):177-190.e8. doi: 10.1016/j.ccell.2018.12.009. Epub 2019 Jan 24. PubMed |
| Cullin5 deficiency promotes small-cell lung cancer metastasis by stabilizing integrin beta1. Zhao G, Gong L, Su D, Jin Y, Guo C, Yue M, Yao S, Qin Z, Ye Y, Tang Y, Wu Q, Zhang J, Cui B, Ding Q, Huang H, Hu L, Chen Y, Zhang P, Hu G, Chen L, Wong KK, Gao D, Ji H. J Clin Invest. 2019 Mar 1;129(3):972-987. doi: 10.1172/JCI122779. Epub 2019 Jan 28. PubMed |
| Therapeutic efficacy of intra-articular delivery of encapsulated human mesenchymal stem cells on early stage osteoarthritis. McKinney JM, Doan TN, Wang L, Deppen J, Reece DS, Pucha KA, Ginn S, Levit RD, Willett NJ. Eur Cell Mater. 2019 Jan 29;37:42-59. doi: 10.22203/eCM.v037a04. PubMed |
| REST and Neural Gene Network Dysregulation in iPSC Models of Alzheimer's Disease. Meyer K, Feldman HM, Lu T, Drake D, Lim ET, Ling KH, Bishop NA, Pan Y, Seo J, Lin YT, Su SC, Church GM, Tsai LH, Yankner BA. Cell Rep. 2019 Jan 29;26(5):1112-1127.e9. doi: 10.1016/j.celrep.2019.01.023. PubMed |
| The EF-Hand Protein CALML6 Suppresses Antiviral Innate Immunity by Impairing IRF3 Dimerization. Wang Z, Sheng C, Yao C, Chen H, Wang D, Chen S. Cell Rep. 2019 Jan 29;26(5):1273-1285.e5. doi: 10.1016/j.celrep.2019.01.030. PubMed |
| Integrated Phosphoproteome and Transcriptome Analysis Reveals Chlamydia-Induced Epithelial-to-Mesenchymal Transition in Host Cells. Zadora PK, Chumduri C, Imami K, Berger H, Mi Y, Selbach M, Meyer TF, Gurumurthy RK. Cell Rep. 2019 Jan 29;26(5):1286-1302.e8. doi: 10.1016/j.celrep.2019.01.006. PubMed |
| Multivalent Role of Human TFIID in Recruiting Elongation Components at the Promoter-Proximal Region for Transcriptional Control. Yadav D, Ghosh K, Basu S, Roeder RG, Biswas D. Cell Rep. 2019 Jan 29;26(5):1303-1317.e7. doi: 10.1016/j.celrep.2019.01.012. PubMed |
| Regenerative potential of mouse embryonic stem cell-derived PDGFRalpha(+) cardiac lineage committed cells in infarcted myocardium. Hong SP, Song S, Lee S, Jo H, Kim HK, Han J, Park JH, Cho SW. World J Stem Cells. 2019 Jan 26;11(1):44-54. doi: 10.4252/wjsc.v11.i1.44. PubMed |
| Wild-Type p53 Promotes Cancer Metabolic Switch by Inducing PUMA-Dependent Suppression of Oxidative Phosphorylation. Kim J, Yu L, Chen W, Xu Y, Wu M, Todorova D, Tang Q, Feng B, Jiang L, He J, Chen G, Fu X, Xu Y. Cancer Cell. 2019 Feb 11;35(2):191-203.e8. doi: 10.1016/j.ccell.2018.12.012. Epub 2019 Jan 31. PubMed |
| Pharmacological Targeting of STK19 Inhibits Oncogenic NRAS-Driven Melanomagenesis. Yin C, Zhu B, Zhang T, Liu T, Chen S, Liu Y, Li X, Miao X, Li S, Mi X, Zhang J, Li L, Wei G, Xu ZX, Gao X, Huang C, Wei Z, Goding CR, Wang P, Deng X, Cui R. Cell. 2019 Feb 21;176(5):1113-1127.e16. doi: 10.1016/j.cell.2019.01.002. Epub 2019 Jan 31. PubMed |
| De Novo PITX1 Expression Controls Bi-Stable Transcriptional Circuits to Govern Self-Renewal and Differentiation in Squamous Cell Carcinoma. Sastre-Perona A, Hoang-Phou S, Leitner MC, Okuniewska M, Meehan S, Schober M. Cell Stem Cell. 2019 Mar 7;24(3):390-404.e8. doi: 10.1016/j.stem.2019.01.003. Epub 2019 Jan 31. PubMed |
| F-box protein FBXO16 functions as a tumor suppressor by attenuating nuclear beta-catenin function. Paul D, Islam S, Manne RK, Dinesh US, Malonia SK, Maity B, Boppana R, Rapole S, Shetty PK, Santra MK. J Pathol. 2019 Jul;248(3):266-279. doi: 10.1002/path.5252. Epub 2019 Mar 8. PubMed |
| Ultraviolet B-induced Otx2 expression in lens epithelial cells promotes epithelial-mesenchymal transition. Yoshitomi Y, Osada H, Satake H, Kojima M, Saito-Takatsuji H, Ikeda T, Yoshitake Y, Ishigaki Y, Kubo E, Sasaki H, Yonekura H. Biol Open. 2019 Feb 18;8(2). pii: bio.035691. doi: 10.1242/bio.035691. PubMed |
| Label-free Quantitative Analysis of Protein Expression Alterations in miR-26a-Knockout HeLa Cells using SWATH-MS Technology. Shen H, Li L, Teng Z, Meng T, Kong X, Hu Y, Zhu Y, Ma L. Sci Rep. 2019 Feb 4;9(1):1399. doi: 10.1038/s41598-018-34904-8. PubMed |
| Targeting NOTCH activation in small cell lung cancer through LSD1 inhibition. Augert A, Eastwood E, Ibrahim AH, Wu N, Grunblatt E, Basom R, Liggitt D, Eaton KD, Martins R, Poirier JT, Rudin CM, Milletti F, Cheng WY, Mack F, MacPherson D. Sci Signal. 2019 Feb 5;12(567). pii: 12/567/eaau2922. doi: 10.1126/scisignal.aau2922. PubMed |
| A Genome-wide Haploid Genetic Screen Identifies Regulators of Glutathione Abundance and Ferroptosis Sensitivity. Cao JY, Poddar A, Magtanong L, Lumb JH, Mileur TR, Reid MA, Dovey CM, Wang J, Locasale JW, Stone E, Cole SPC, Carette JE, Dixon SJ. Cell Rep. 2019 Feb 5;26(6):1544-1556.e8. doi: 10.1016/j.celrep.2019.01.043. PubMed |
Specific, sensitive and stable reporting of human mesenchymal stromal cell chondrogenesis.
De La Vega RE, Scheu M, Brown LA, Evans C, Ferreira E, Porter RM.
Tissue Eng Part C Methods. 2019 Feb 6. doi: 10.1089/ten.TEC.2018.0295.
PubMed
Associated Plasmids |
| Tracing cellular heterogeneity in pooled genetic screens via multi-level barcoding. Boettcher M, Covarrubias S, Biton A, Blau J, Wang H, Zaitlen N, McManus MT. BMC Genomics. 2019 Feb 6;20(1):107. doi: 10.1186/s12864-019-5480-0. PubMed |
| Resveratrol enhances pluripotency of mouse embryonic stem cells by activating AMPK/Ulk1 pathway. Suvorova II, Knyazeva AR, Petukhov AV, Aksenov ND, Pospelov VA. Cell Death Discov. 2019 Feb 4;5:61. doi: 10.1038/s41420-019-0137-y. eCollection 2019. PubMed |
| Genome-Scale CRISPR/Cas9 Screening Reveals Squalene Epoxidase as a Susceptibility Factor for Cytotoxicity of Malformin A1. Koizumi Y, Fukushima J, Kobayashi Y, Kadowaki A, Natsui M, Yamaguchi T, Imai Y, Sugiyama T, Kuba K. Chembiochem. 2019 Jun 14;20(12):1563-1568. doi: 10.1002/cbic.201800769. Epub 2019 Apr 18. PubMed |
| Widespread and Functional RNA Circularization in Localized Prostate Cancer. Chen S, Huang V, Xu X, Livingstone J, Soares F, Jeon J, Zeng Y, Hua JT, Petricca J, Guo H, Wang M, Yousif F, Zhang Y, Donmez N, Ahmed M, Volik S, Lapuk A, Chua MLK, Heisler LE, Foucal A, Fox NS, Fraser M, Bhandari V, Shiah YJ, Guan J, Li J, Orain M, Picard V, Hovington H, Bergeron A, Lacombe L, Fradet Y, Tetu B, Liu S, Feng F, Wu X, Shao YW, Komor MA, Sahinalp C, Collins C, Hoogstrate Y, de Jong M, Fijneman RJA, Fei T, Jenster G, van der Kwast T, Bristow RG, Boutros PC, He HH. Cell. 2019 Feb 7;176(4):831-843.e22. doi: 10.1016/j.cell.2019.01.025. PubMed |
| Niclosamide activates the NLRP3 inflammasome by intracellular acidification and mitochondrial inhibition. Thi Tran U, Kitami T. Commun Biol. 2019 Jan 3;2:2. doi: 10.1038/s42003-018-0244-y. eCollection 2019. PubMed |
| Hectd3 promotes pathogenic Th17 lineage through Stat3 activation and Malt1 signaling in neuroinflammation. Cho JJ, Xu Z, Parthasarathy U, Drashansky TT, Helm EY, Zuniga AN, Lorentsen KJ, Mansouri S, Cho JY, Edelmann MJ, Duong DM, Gehring T, Seeholzer T, Krappmann D, Uddin MN, Califano D, Wang RL, Jin L, Li H, Lv D, Zhou D, Zhou L, Avram D. Nat Commun. 2019 Feb 11;10(1):701. doi: 10.1038/s41467-019-08605-3. PubMed |
| Identification of diterpenoid compounds that interfere with Fli-1 DNA binding to suppress leukemogenesis. Liu T, Xia L, Yao Y, Yan C, Fan Y, Gajendran B, Yang J, Li YJ, Chen J, Filmus J, Spaner DE, Zacksenhaus E, Hao X, Ben-David Y. Cell Death Dis. 2019 Feb 11;10(2):117. doi: 10.1038/s41419-019-1363-1. PubMed |
| POH1 contributes to hyperactivation of TGF-beta signaling and facilitates hepatocellular carcinoma metastasis through deubiquitinating TGF-beta receptors and caveolin-1. Wang B, Xu X, Yang Z, Zhang L, Liu Y, Ma A, Xu G, Tang M, Jing T, Wu L, Liu Y. EBioMedicine. 2019 Mar;41:320-332. doi: 10.1016/j.ebiom.2019.01.058. Epub 2019 Feb 7. PubMed |
| Nuclear RNA foci from C9ORF72 expansion mutation form paraspeckle-like bodies. Bajc Cesnik A, Darovic S, Prpar Mihevc S, Stalekar M, Malnar M, Motaln H, Lee YB, Mazej J, Pohleven J, Grosch M, Modic M, Fonovic M, Turk B, Drukker M, Shaw CE, Rogelj B. J Cell Sci. 2019 Mar 7;132(5). pii: jcs.224303. doi: 10.1242/jcs.224303. PubMed |
| p53 Is a Master Regulator of Proteostasis in SMARCB1-Deficient Malignant Rhabdoid Tumors. Carugo A, Minelli R, Sapio L, Soeung M, Carbone F, Robinson FS, Tepper J, Chen Z, Lovisa S, Svelto M, Amin S, Srinivasan S, Del Poggetto E, Loponte S, Puca F, Dey P, Malouf GG, Su X, Li L, Lopez-Terrada D, Rakheja D, Lazar AJ, Netto GJ, Rao P, Sgambato A, Maitra A, Tripathi DN, Walker CL, Karam JA, Heffernan TP, Viale A, Roberts CWM, Msaouel P, Tannir NM, Draetta GF, Genovese G. Cancer Cell. 2019 Feb 11;35(2):204-220.e9. doi: 10.1016/j.ccell.2019.01.006. PubMed |
| Aging-like Spontaneous Epigenetic Silencing Facilitates Wnt Activation, Stemness, and Braf(V600E)-Induced Tumorigenesis. Tao Y, Kang B, Petkovich DA, Bhandari YR, In J, Stein-O'Brien G, Kong X, Xie W, Zachos N, Maegawa S, Vaidya H, Brown S, Chiu Yen RW, Shao X, Thakor J, Lu Z, Cai Y, Zhang Y, Mallona I, Peinado MA, Zahnow CA, Ahuja N, Fertig E, Issa JP, Baylin SB, Easwaran H. Cancer Cell. 2019 Feb 11;35(2):315-328.e6. doi: 10.1016/j.ccell.2019.01.005. PubMed |
| Human Cytomegalovirus Immediate Early 86-kDa Protein Blocks Transcription and Induces Degradation of the Immature Interleukin-1beta Protein during Virion-Mediated Activation of the AIM2 Inflammasome. Botto S, Abraham J, Mizuno N, Pryke K, Gall B, Landais I, Streblow DN, Fruh KJ, DeFilippis VR. MBio. 2019 Feb 12;10(1). pii: mBio.02510-18. doi: 10.1128/mBio.02510-18. PubMed |
| Experimental and Computational Approaches for Single-Cell Enhancer Perturbation Assay. Xie S, Hon GC. Methods Mol Biol. 2019;1935:203-221. doi: 10.1007/978-1-4939-9057-3_14. PubMed |
Delivering SaCas9 mRNA by lentivirus-like bionanoparticles for transient expression and efficient genome editing.
Lu B, Javidi-Parsijani P, Makani V, Mehraein-Ghomi F, Sarhan WM, Sun D, Yoo KW, Atala ZP, Lyu P, Atala A.
Nucleic Acids Res. 2019 Feb 13. pii: 5316732. doi: 10.1093/nar/gkz093.
PubMed
Associated Plasmids |
| Release of Immunomodulatory Ebola Virus Glycoprotein-Containing Microvesicles Is Suppressed by Tetherin in a Species-Specific Manner. Nehls J, Businger R, Hoffmann M, Brinkmann C, Fehrenbacher B, Schaller M, Maurer B, Schonfeld C, Kramer D, Hailfinger S, Pohlmann S, Schindler M. Cell Rep. 2019 Feb 12;26(7):1841-1853.e6. doi: 10.1016/j.celrep.2019.01.065. PubMed |
| A20 Orchestrates Inflammatory Response in the Oral Mucosa through Restraining NF-kappaB Activity. Li Y, Mooney EC, Holden SE, Xia XJ, Cohen DJ, Walsh SW, Ma A, Sahingur SE. J Immunol. 2019 Apr 1;202(7):2044-2056. doi: 10.4049/jimmunol.1801286. Epub 2019 Feb 13. PubMed |
| Egr2 overexpression in Schwann cells increases myelination frequency in vitro. Tammia M, Mi R, Sluch VM, Zhu A, Chung T, Shinn D, Zack DJ, Hoke A, Mao HQ. Heliyon. 2018 Nov 29;4(11):e00982. doi: 10.1016/j.heliyon.2018.e00982. eCollection 2018 Nov. PubMed |
| MicroRNA-375 Suppresses the Growth and Invasion of Fibrolamellar Carcinoma. Dinh TA, Jewell ML, Kanke M, Francisco A, Sritharan R, Turnham RE, Lee S, Kastenhuber ER, Wauthier E, Guy CD, Yeung RS, Lowe SW, Reid LM, Scott JD, Diehl AM, Sethupathy P. Cell Mol Gastroenterol Hepatol. 2019;7(4):803-817. doi: 10.1016/j.jcmgh.2019.01.008. Epub 2019 Feb 11. PubMed |
| Heterochromatin anomalies and double-stranded RNA accumulation underlie C9orf72 poly(PR) toxicity. Zhang YJ, Guo L, Gonzales PK, Gendron TF, Wu Y, Jansen-West K, O'Raw AD, Pickles SR, Prudencio M, Carlomagno Y, Gachechiladze MA, Ludwig C, Tian R, Chew J, DeTure M, Lin WL, Tong J, Daughrity LM, Yue M, Song Y, Andersen JW, Castanedes-Casey M, Kurti A, Datta A, Antognetti G, McCampbell A, Rademakers R, Oskarsson B, Dickson DW, Kampmann M, Ward ME, Fryer JD, Link CD, Shorter J, Petrucelli L. Science. 2019 Feb 15;363(6428). pii: 363/6428/eaav2606. doi: 10.1126/science.aav2606. PubMed |
| O-GlcNAc Transferase Suppresses Inflammation and Necroptosis by Targeting Receptor-Interacting Serine/Threonine-Protein Kinase 3. Li X, Gong W, Wang H, Li T, Attri KS, Lewis RE, Kalil AC, Bhinderwala F, Powers R, Yin G, Herring LE, Asara JM, Lei YL, Yang X, Rodriguez DA, Yang M, Green DR, Singh PK, Wen H. Immunity. 2019 Mar 19;50(3):576-590.e6. doi: 10.1016/j.immuni.2019.01.007. Epub 2019 Feb 12. PubMed |
| Bi-allelic Variants in TONSL Cause SPONASTRIME Dysplasia and a Spectrum of Skeletal Dysplasia Phenotypes. Burrage LC, Reynolds JJ, Baratang NV, Phillips JB, Wegner J, McFarquhar A, Higgs MR, Christiansen AE, Lanza DG, Seavitt JR, Jain M, Li X, Parry DA, Raman V, Chitayat D, Chinn IK, Bertuch AA, Karaviti L, Schlesinger AE, Earl D, Bamshad M, Savarirayan R, Doddapaneni H, Muzny D, Jhangiani SN, Eng CM, Gibbs RA, Bi W, Emrick L, Rosenfeld JA, Postlethwait J, Westerfield M, Dickinson ME, Beaudet AL, Ranza E, Huber C, Cormier-Daire V, Shen W, Mao R, Heaney JD, Orange JS, Bertola D, Yamamoto GL, Baratela WAR, Butler MG, Ali A, Adeli M, Cohn DH, Krakow D, Jackson AP, Lees M, Offiah AC, Carlston CM, Carey JC, Stewart GS, Bacino CA, Campeau PM, Lee B. Am J Hum Genet. 2019 Mar 7;104(3):422-438. doi: 10.1016/j.ajhg.2019.01.007. Epub 2019 Feb 14. PubMed |
| Histone Acetyltransferase p300 Induces De Novo Super-Enhancers to Drive Cellular Senescence. Sen P, Lan Y, Li CY, Sidoli S, Donahue G, Dou Z, Frederick B, Chen Q, Luense LJ, Garcia BA, Dang W, Johnson FB, Adams PD, Schultz DC, Berger SL. Mol Cell. 2019 Feb 21;73(4):684-698.e8. doi: 10.1016/j.molcel.2019.01.021. Epub 2019 Feb 14. PubMed |
| ARv7 Represses Tumor-Suppressor Genes in Castration-Resistant Prostate Cancer. Cato L, de Tribolet-Hardy J, Lee I, Rottenberg JT, Coleman I, Melchers D, Houtman R, Xiao T, Li W, Uo T, Sun S, Kuznik NC, Goppert B, Ozgun F, van Royen ME, Houtsmuller AB, Vadhi R, Rao PK, Li L, Balk SP, Den RB, Trock BJ, Karnes RJ, Jenkins RB, Klein EA, Davicioni E, Gruhl FJ, Long HW, Liu XS, Cato ACB, Lack NA, Nelson PS, Plymate SR, Groner AC, Brown M. Cancer Cell. 2019 Mar 18;35(3):401-413.e6. doi: 10.1016/j.ccell.2019.01.008. Epub 2019 Feb 14. PubMed |
| SIRT3 promotes antimycobacterial defenses by coordinating mitochondrial and autophagic functions. Kim TS, Jin YB, Kim YS, Kim S, Kim JK, Lee HM, Suh HW, Choe JH, Kim YJ, Koo BS, Kim HN, Jung M, Lee SH, Kim DK, Chung C, Son JW, Min JJ, Kim JM, Deng CX, Kim HS, Lee SR, Jo EK. Autophagy. 2019 Aug;15(8):1356-1375. doi: 10.1080/15548627.2019.1582743. Epub 2019 Mar 4. PubMed |
| Teneurin C-Terminal Associated Peptide (TCAP)-1 and Latrophilin Interaction in HEK293 Cells: Evidence for Modulation of Intercellular Adhesion. Husic M, Barsyte-Lovejoy D, Lovejoy DA. Front Endocrinol (Lausanne). 2019 Feb 1;10:22. doi: 10.3389/fendo.2019.00022. eCollection 2019. PubMed |
| Anti-silencing function 1B histone chaperone promotes cell proliferation and migration via activation of the AKT pathway in clear cell renal cell carcinoma. Jiangqiao Z, Tao Q, Zhongbao C, Xiaoxiong M, Long Z, Jilin Z, Tianyu W. Biochem Biophys Res Commun. 2019 Mar 26;511(1):165-172. doi: 10.1016/j.bbrc.2019.02.060. Epub 2019 Feb 15. PubMed |
| Metastasis-associated protein 1 (MTA1) is transferred by exosomes and contributes to the regulation of hypoxia and estrogen signaling in breast cancer cells. Hannafon BN, Gin AL, Xu YF, Bruns M, Calloway CL, Ding WQ. Cell Commun Signal. 2019 Feb 19;17(1):13. doi: 10.1186/s12964-019-0325-7. PubMed |
Fibroblast growth factor receptor influences primary cilium length through an interaction with intestinal cell kinase.
Kunova Bosakova M, Nita A, Gregor T, Varecha M, Gudernova I, Fafilek B, Barta T, Basheer N, Abraham SP, Balek L, Tomanova M, Fialova Kucerova J, Bosak J, Potesil D, Zieba J, Song J, Konik P, Park S, Duran I, Zdrahal Z, Smajs D, Jansen G, Fu Z, Ko HW, Hampl A, Trantirek L, Krakow D, Krejci P.
Proc Natl Acad Sci U S A. 2019 Feb 19. pii: 1800338116. doi: 10.1073/pnas.1800338116.
PubMed
Associated Plasmids |
| Production of High-Titer Lentiviral Particles for Stable Genetic Modification of Mammalian Cells. Larcombe MR, Manent J, Chen J, Mishra K, Liu X, Nefzger CM. Methods Mol Biol. 2019;1940:47-61. doi: 10.1007/978-1-4939-9086-3_4. PubMed |
| Identification of Broad-Spectrum Antiviral Compounds by Targeting Viral Entry. Mazzon M, Ortega-Prieto AM, Imrie D, Luft C, Hess L, Czieso S, Grove J, Skelton JK, Farleigh L, Bugert JJ, Wright E, Temperton N, Angell R, Oxenford S, Jacobs M, Ketteler R, Dorner M, Marsh M. Viruses. 2019 Feb 20;11(2). pii: v11020176. doi: 10.3390/v11020176. PubMed |
| A metabolic switch in proteasome inhibitor resistant multiple myeloma ensures higher mitochondrial metabolism, protein folding and sphingomyelin synthesis. Besse L, Besse A, Mendez-Lopez M, Vasickova K, Sedlackova M, Vanhara P, Kraus M, Bader J, Ferreira RB, Castellano RK, Law BK, Driessen C. Haematologica. 2019 Feb 21. pii: haematol.2018.207704. doi: 10.3324/haematol.2018.207704. PubMed |
| Calcium Channel Subunit alpha2delta4 Is Regulated by Early Growth Response 1 and Facilitates Epileptogenesis. van Loo KMJ, Rummel CK, Pitsch J, Muller JA, Bikbaev AF, Martinez-Chavez E, Blaess S, Dietrich D, Heine M, Becker AJ, Schoch S. J Neurosci. 2019 Apr 24;39(17):3175-3187. doi: 10.1523/JNEUROSCI.1731-18.2019. Epub 2019 Feb 21. PubMed |
Pan-Cancer Analyses Reveal Genomic Features of FOXM1 Overexpression in Cancer.
Barger CJ, Branick C, Chee L, Karpf AR.
Cancers (Basel). 2019 Feb 21;11(2). pii: cancers11020251. doi: 10.3390/cancers11020251.
PubMed
Associated Plasmids |
| Protein phosphatase 2A Aalpha regulates Abeta protein expression and stability. O'Connor CM, Hoffa MT, Taylor SE, Avelar RA, Narla G. J Biol Chem. 2019 Apr 12;294(15):5923-5934. doi: 10.1074/jbc.RA119.007593. Epub 2019 Feb 22. PubMed |
| Telomere-dependent and telomere-independent roles of RAP1 in regulating human stem cell homeostasis. Zhang X, Liu Z, Liu X, Wang S, Zhang Y, He X, Sun S, Ma S, Shyh-Chang N, Liu F, Wang Q, Wang X, Liu L, Zhang W, Song M, Liu GH, Qu J. Protein Cell. 2019 Feb 22. pii: 10.1007/s13238-019-0610-7. doi: 10.1007/s13238-019-0610-7. PubMed |
| Targeting an RNA-Binding Protein Network in Acute Myeloid Leukemia. Wang E, Lu SX, Pastore A, Chen X, Imig J, Chun-Wei Lee S, Hockemeyer K, Ghebrechristos YE, Yoshimi A, Inoue D, Ki M, Cho H, Bitner L, Kloetgen A, Lin KT, Uehara T, Owa T, Tibes R, Krainer AR, Abdel-Wahab O, Aifantis I. Cancer Cell. 2019 Mar 18;35(3):369-384.e7. doi: 10.1016/j.ccell.2019.01.010. Epub 2019 Feb 21. PubMed |
| Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion. Harris IS, Endress JE, Coloff JL, Selfors LM, McBrayer SK, Rosenbluth JM, Takahashi N, Dhakal S, Koduri V, Oser MG, Schauer NJ, Doherty LM, Hong AL, Kang YP, Younger ST, Doench JG, Hahn WC, Buhrlage SJ, DeNicola GM, Kaelin WG Jr, Brugge JS. Cell Metab. 2019 May 7;29(5):1166-1181.e6. doi: 10.1016/j.cmet.2019.01.020. Epub 2019 Feb 21. PubMed |
NFIA is a gliogenic switch enabling rapid derivation of functional human astrocytes from pluripotent stem cells.
Tchieu J, Calder EL, Guttikonda SR, Gutzwiller EM, Aromolaran KA, Steinbeck JA, Goldstein PA, Studer L.
Nat Biotechnol. 2019 Mar;37(3):267-275. doi: 10.1038/s41587-019-0035-0. Epub 2019 Feb 25.
PubMed
Associated Plasmids |
| FBXO22 promotes the development of hepatocellular carcinoma by regulating the ubiquitination and degradation of p21. Zhang L, Chen J, Ning D, Liu Q, Wang C, Zhang Z, Chu L, Yu C, Liang HF, Zhang B, Chen X. J Exp Clin Cancer Res. 2019 Feb 26;38(1):101. doi: 10.1186/s13046-019-1058-6. PubMed |
| Highly Purified Human Extracellular Vesicles Produced by Stem Cells Alleviate Aging Cellular Phenotypes of Senescent Human Cells. Liu S, Mahairaki V, Bai H, Ding Z, Li J, Witwer KW, Cheng L. Stem Cells. 2019 Jun;37(6):779-790. doi: 10.1002/stem.2996. Epub 2019 Mar 12. PubMed |
| PRMT5 Modulates Splicing for Genome Integrity and Preserves Proteostasis of Hematopoietic Stem Cells. Tan DQ, Li Y, Yang C, Li J, Tan SH, Chin DWL, Nakamura-Ishizu A, Yang H, Suda T. Cell Rep. 2019 Feb 26;26(9):2316-2328.e6. doi: 10.1016/j.celrep.2019.02.001. PubMed |
| Functional Profiling Identifies Determinants of Arsenic Trioxide Cellular Toxicity. Sobh A, Loguinov A, Yazici GN, Zeidan RS, Tagmount A, Hejazi NS, Hubbard AE, Zhang L, Vulpe CD. Toxicol Sci. 2019 May 1;169(1):108-121. doi: 10.1093/toxsci/kfz024. PubMed |
| Unique properties of PTEN-L contribute to neuroprotection in response to ischemic-like stress. Jochner MCE, An J, Lattig-Tunnemann G, Kirchner M, Dagane A, Dittmar G, Dirnagl U, Eickholt BJ, Harms C. Sci Rep. 2019 Feb 28;9(1):3183. doi: 10.1038/s41598-019-39438-1. PubMed |
| High-resolution characterization of centriole distal appendage morphology and dynamics by correlative STORM and electron microscopy. Bowler M, Kong D, Sun S, Nanjundappa R, Evans L, Farmer V, Holland A, Mahjoub MR, Sui H, Loncarek J. Nat Commun. 2019 Mar 1;10(1):993. doi: 10.1038/s41467-018-08216-4. PubMed |
| The stability of Magoh and Y14 depends on their heterodimer formation and nuclear localization. Ma Q, Tatsuno T, Nakamura Y, Ishigaki Y. Biochem Biophys Res Commun. 2019 Apr 9;511(3):631-636. doi: 10.1016/j.bbrc.2019.02.097. Epub 2019 Feb 27. PubMed |
| A novel L1CAM isoform with angiogenic activity generated by NOVA2-mediated alternative splicing. Angiolini F, Belloni E, Giordano M, Campioni M, Forneris F, Paronetto MP, Lupia M, Brandas C, Pradella D, Di Matteo A, Giampietro C, Jodice G, Luise C, Bertalot G, Freddi S, Malinverno M, Irimia M, Moulton JD, Summerton J, Chiapparino A, Ghilardi C, Giavazzi R, Nyqvist D, Gabellini D, Dejana E, Cavallaro U, Ghigna C. Elife. 2019 Mar 4;8. pii: 44305. doi: 10.7554/eLife.44305. PubMed |
| BETP degradation simultaneously targets acute myelogenous leukemia stem cells and the microenvironment. Piya S, Mu H, Bhattacharya S, Lorenzi PL, Davis RE, McQueen T, Ruvolo V, Baran N, Wang Z, Qian Y, Crews CM, Konopleva M, Ishizawa J, You MJ, Kantarjian H, Andreeff M, Borthakur G. J Clin Invest. 2019 Feb 21;129(5):1878-1894. doi: 10.1172/JCI120654. Print 2019 May 1. PubMed |
| Circular synthesized CRISPR/Cas gRNAs for functional interrogations in the coding and noncoding genome. Wegner M, Diehl V, Bittl V, de Bruyn R, Wiechmann S, Matthess Y, Hebel M, Hayes MG, Schaubeck S, Benner C, Heinz S, Bremm A, Dikic I, Ernst A, Kaulich M. Elife. 2019 Mar 6;8. pii: 42549. doi: 10.7554/eLife.42549. PubMed |
| Human Pluripotent Stem Cell-Derived Tumor Model Uncovers the Embryonic Stem Cell Signature as a Key Driver in Atypical Teratoid/Rhabdoid Tumor. Terada Y, Jo N, Arakawa Y, Sakakura M, Yamada Y, Ukai T, Kabata M, Mitsunaga K, Mineharu Y, Ohta S, Nakagawa M, Miyamoto S, Yamamoto T, Yamada Y. Cell Rep. 2019 Mar 5;26(10):2608-2621.e6. doi: 10.1016/j.celrep.2019.02.009. PubMed |
| Myeloid Folliculin balances mTOR activation to maintain innate immunity homeostasis. Li J, Wada S, Weaver LK, Biswas C, Behrens EM, Arany Z. JCI Insight. 2019 Mar 7;5. pii: 126939. doi: 10.1172/jci.insight.126939. PubMed |
| TZAP plays an inhibitory role in the self-renewal of porcine mesenchymal stromal cells and is implicated the regulation of premature senescence via the p53 pathway. Bie YN, Gu P, Chen YT, Zhou XX, Tian YG, Yang Q, Li HY, Lin X, Guan YH, Lin TY, Lu X, Shen HF, Fang TX, Liu YM, Xiao D, Gu WW. J Transl Med. 2019 Mar 7;17(1):72. doi: 10.1186/s12967-019-1820-8. PubMed |
| Induction of Potent Neutralizing Antibody Responses by a Designed Protein Nanoparticle Vaccine for Respiratory Syncytial Virus. Marcandalli J, Fiala B, Ols S, Perotti M, de van der Schueren W, Snijder J, Hodge E, Benhaim M, Ravichandran R, Carter L, Sheffler W, Brunner L, Lawrenz M, Dubois P, Lanzavecchia A, Sallusto F, Lee KK, Veesler D, Correnti CE, Stewart LJ, Baker D, Lore K, Perez L, King NP. Cell. 2019 Mar 7;176(6):1420-1431.e17. doi: 10.1016/j.cell.2019.01.046. PubMed |
| LAMB3 mediates apoptotic, proliferative, invasive, and metastatic behaviors in pancreatic cancer by regulating the PI3K/Akt signaling pathway. Zhang H, Pan YZ, Cheung M, Cao M, Yu C, Chen L, Zhan L, He ZW, Sun CY. Cell Death Dis. 2019 Mar 8;10(3):230. doi: 10.1038/s41419-019-1320-z. PubMed |
| MAP4K4 Inhibition Promotes Survival of Human Stem Cell-Derived Cardiomyocytes and Reduces Infarct Size In Vivo. Fiedler LR, Chapman K, Xie M, Maifoshie E, Jenkins M, Golforoush PA, Bellahcene M, Noseda M, Faust D, Jarvis A, Newton G, Paiva MA, Harada M, Stuckey DJ, Song W, Habib J, Narasimhan P, Aqil R, Sanmugalingam D, Yan R, Pavanello L, Sano M, Wang SC, Sampson RD, Kanayaganam S, Taffet GE, Michael LH, Entman ML, Tan TH, Harding SE, Low CMR, Tralau-Stewart C, Perrior T, Schneider MD. Cell Stem Cell. 2019 Apr 4;24(4):579-591.e12. doi: 10.1016/j.stem.2019.01.013. Epub 2019 Mar 7. PubMed |
| Kaiso is required for MTG16-dependent effects on colitis-associated carcinoma. Short SP, Barrett CW, Stengel KR, Revetta FL, Choksi YA, Coburn LA, Lintel MK, McDonough EM, Washington MK, Wilson KT, Prokhortchouk E, Chen X, Hiebert SW, Reynolds AB, Williams CS. Oncogene. 2019 Jun;38(25):5091-5106. doi: 10.1038/s41388-019-0777-7. Epub 2019 Mar 11. PubMed |
| Replication Study: The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44. Yan X, Tang B, Chen B, Shan Y, Yang H, Iorns E, Tsui R, Denis A, Perfito N, Errington TM. Elife. 2019 Mar 12;8. pii: 43511. doi: 10.7554/eLife.43511. PubMed |
| Integrin alpha6beta4E variant is associated with actin and CD9 structures and modifies the biophysical properties of cell-cell and cell-extracellular matrix interactions. Wang M, Hinton JP, Gard JMC, Garcia JGN, Knudsen BS, Nagle RB, Cress AE. Mol Biol Cell. 2019 Mar 21;30(7):838-850. doi: 10.1091/mbc.E18-10-0652. Epub 2019 Mar 13. PubMed |
| Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity. Aho ER, Wang J, Gogliotti RD, Howard GC, Phan J, Acharya P, Macdonald JD, Cheng K, Lorey SL, Lu B, Wenzel S, Foshage AM, Alvarado J, Wang F, Shaw JG, Zhao B, Weissmiller AM, Thomas LR, Vakoc CR, Hall MD, Hiebert SW, Liu Q, Stauffer SR, Fesik SW, Tansey WP. Cell Rep. 2019 Mar 12;26(11):2916-2928.e13. doi: 10.1016/j.celrep.2019.02.047. PubMed |
| p53 Promotes Cancer Cell Adaptation to Glutamine Deprivation by Upregulating Slc7a3 to Increase Arginine Uptake. Lowman XH, Hanse EA, Yang Y, Ishak Gabra MB, Tran TQ, Li H, Kong M. Cell Rep. 2019 Mar 12;26(11):3051-3060.e4. doi: 10.1016/j.celrep.2019.02.037. PubMed |
| The lncRNA TP73-AS1 is linked to aggressiveness in glioblastoma and promotes temozolomide resistance in glioblastoma cancer stem cells. Mazor G, Levin L, Picard D, Ahmadov U, Caren H, Borkhardt A, Reifenberger G, Leprivier G, Remke M, Rotblat B. Cell Death Dis. 2019 Mar 13;10(3):246. doi: 10.1038/s41419-019-1477-5. PubMed |
| Quantification of human neuromuscular function through optogenetics. Vila OF, Uzel SGM, Ma SP, Williams D, Pak J, Kamm RD, Vunjak-Novakovic G. Theranostics. 2019 Jan 31;9(5):1232-1246. doi: 10.7150/thno.25735. eCollection 2019. PubMed |
| TFEB-driven lysosomal biogenesis is pivotal for PGC1alpha-dependent renal stress resistance. Lynch MR, Tran MT, Ralto KM, Zsengeller ZK, Raman V, Bhasin SS, Sun N, Chen X, Brown D, Rovira II, Taguchi K, Brooks CR, Stillman IE, Bhasin MK, Finkel T, Parikh SM. JCI Insight. 2019 Mar 14;5. pii: 126749. doi: 10.1172/jci.insight.126749. PubMed |
| Rapid and reversible suppression of ALT by DAXX in osteosarcoma cells. Yost KE, Clatterbuck Soper SF, Walker RL, Pineda MA, Zhu YJ, Ester CD, Showman S, Roschke AV, Waterfall JJ, Meltzer PS. Sci Rep. 2019 Mar 14;9(1):4544. doi: 10.1038/s41598-019-41058-8. PubMed |
| EZH2 Inhibition in Ewing Sarcoma Upregulates GD2 Expression for Targeting with Gene-Modified T Cells. Kailayangiri S, Altvater B, Lesch S, Balbach S, Gottlich C, Kuhnemundt J, Mikesch JH, Schelhaas S, Jamitzky S, Meltzer J, Farwick N, Greune L, Fluegge M, Kerl K, Lode HN, Siebert N, Muller I, Walles H, Hartmann W, Rossig C. Mol Ther. 2019 May 8;27(5):933-946. doi: 10.1016/j.ymthe.2019.02.014. Epub 2019 Feb 23. PubMed |
Single-Cell Proteomics Reveal that Quantitative Changes in Co-expressed Lineage-Specific Transcription Factors Determine Cell Fate.
Palii CG, Cheng Q, Gillespie MA, Shannon P, Mazurczyk M, Napolitani G, Price ND, Ranish JA, Morrissey E, Higgs DR, Brand M.
Cell Stem Cell. 2019 May 2;24(5):812-820.e5. doi: 10.1016/j.stem.2019.02.006. Epub 2019 Mar 14.
PubMed
Associated Plasmids |
| Optimization of lentiviral transduction parameters and its application for CRISPR-based secretome modification of human endometrial mesenchymal stem cells. Deryabin P, Griukova A, Shatrova A, Petukhov A, Nikolsky N, Borodkina A. Cell Cycle. 2019 Mar - Apr;18(6-7):742-758. doi: 10.1080/15384101.2019.1593650. Epub 2019 Mar 28. PubMed |
| The TLR4 adaptor TRAM controls the phagocytosis of Gram-negative bacteria by interacting with the Rab11-family interacting protein 2. Skjesol A, Yurchenko M, Bosl K, Gravastrand C, Nilsen KE, Grovdal LM, Agliano F, Patane F, Lentini G, Kim H, Teti G, Kumar Sharma A, Kandasamy RK, Sporsheim B, Starheim KK, Golenbock DT, Stenmark H, McCaffrey M, Espevik T, Husebye H. PLoS Pathog. 2019 Mar 18;15(3):e1007684. doi: 10.1371/journal.ppat.1007684. eCollection 2019 Mar. PubMed |
| Logic-Gated ROR1 Chimeric Antigen Receptor Expression Rescues T Cell-Mediated Toxicity to Normal Tissues and Enables Selective Tumor Targeting. Srivastava S, Salter AI, Liggitt D, Yechan-Gunja S, Sarvothama M, Cooper K, Smythe KS, Dudakov JA, Pierce RH, Rader C, Riddell SR. Cancer Cell. 2019 Mar 18;35(3):489-503.e8. doi: 10.1016/j.ccell.2019.02.003. PubMed |
| DNA Replication Vulnerabilities Render Ovarian Cancer Cells Sensitive to Poly(ADP-Ribose) Glycohydrolase Inhibitors. Pillay N, Tighe A, Nelson L, Littler S, Coulson-Gilmer C, Bah N, Golder A, Bakker B, Spierings DCJ, James DI, Smith KM, Jordan AM, Morgan RD, Ogilvie DJ, Foijer F, Jackson DA, Taylor SS. Cancer Cell. 2019 Mar 18;35(3):519-533.e8. doi: 10.1016/j.ccell.2019.02.004. PubMed |
| Chronic optogenetic induction of stress granules is cytotoxic and reveals the evolution of ALS-FTD pathology. Zhang P, Fan B, Yang P, Temirov J, Messing J, Kim HJ, Taylor JP. Elife. 2019 Mar 20;8. pii: 39578. doi: 10.7554/eLife.39578. PubMed |
| Autaptic cultures of human induced neurons as a versatile platform for studying synaptic function and neuronal morphology. Fenske P, Grauel MK, Brockmann MM, Dorrn AL, Trimbuch T, Rosenmund C. Sci Rep. 2019 Mar 20;9(1):4890. doi: 10.1038/s41598-019-41259-1. PubMed |
| Genome-wide CRISPR screen reveals PSMA6 to be an essential gene in pancreatic cancer cells. Bakke J, Wright WC, Zamora AE, Oladimeji P, Crawford JC, Brewer CT, Autry RJ, Evans WE, Thomas PG, Chen T. BMC Cancer. 2019 Mar 21;19(1):253. doi: 10.1186/s12885-019-5455-1. PubMed |
Induced Neurons for the Study of Neurodegenerative and Neurodevelopmental Disorders.
Sauter EJ, Kutsche LK, Klapper SD, Busskamp V.
Methods Mol Biol. 2019;1942:101-121. doi: 10.1007/978-1-4939-9080-1_9.
PubMed
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| Characterization of the ERG-regulated Kinome in Prostate Cancer Identifies TNIK as a Potential Therapeutic Target. Lee RS, Zhang L, Berger A, Lawrence MG, Song J, Niranjan B, Davies RG, Lister NL, Sandhu SK, Rubin MA, Risbridger GP, Taylor RA, Rickman DS, Horvath LG, Daly RJ. Neoplasia. 2019 Apr;21(4):389-400. doi: 10.1016/j.neo.2019.02.005. Epub 2019 Mar 20. PubMed |
| WNT3a and WNT5a Transported by Exosomes Activate WNT Signaling Pathways in Human Cardiac Fibroblasts. Dzialo E, Rudnik M, Koning RI, Czepiel M, Tkacz K, Baj-Krzyworzeka M, Distler O, Siedlar M, Kania G, Blyszczuk P. Int J Mol Sci. 2019 Mar 21;20(6). pii: ijms20061436. doi: 10.3390/ijms20061436. PubMed |
| Elevated Heme Synthesis and Uptake Underpin Intensified Oxidative Metabolism and Tumorigenic Functions in Non-Small Cell Lung Cancer Cells. Sohoni S, Ghosh P, Wang T, Kalainayakan SP, Vidal C, Dey S, Konduri PC, Zhang L. Cancer Res. 2019 May 15;79(10):2511-2525. doi: 10.1158/0008-5472.CAN-18-2156. Epub 2019 Mar 22. PubMed |
| Substrate mechanics controls adipogenesis through YAP phosphorylation by dictating cell spreading. Oliver-De La Cruz J, Nardone G, Vrbsky J, Pompeiano A, Perestrelo AR, Capradossi F, Melajova K, Filipensky P, Forte G. Biomaterials. 2019 Jun;205:64-80. doi: 10.1016/j.biomaterials.2019.03.009. Epub 2019 Mar 16. PubMed |
| Cut-and-Run: A Distinct Mechanism by which V(D)J Recombination Causes Genome Instability. Kirkham CM, Scott JNF, Wang X, Smith AL, Kupinski AP, Ford AM, Westhead DR, Stockley PG, Tuma R, Boyes J. Mol Cell. 2019 May 2;74(3):584-597.e9. doi: 10.1016/j.molcel.2019.02.025. Epub 2019 Mar 21. PubMed |
| Exome Sequencing of ABCB5 Identifies Recurrent Melanoma Mutations that Result in Increased Proliferative and Invasive Capacities. Sana G, Madigan JP, Gartner JJ, Fourrez M, Lin J, Qutob N, Narayan J, Shukla S, Ambudkar SV, Xia D, Rosenberg SA, Gottesman MM, Samuels Y, Gillet JP. J Invest Dermatol. 2019 Mar 21. pii: S0022-202X(19)31330-2. doi: 10.1016/j.jid.2019.01.036. PubMed |
| miR-338-3p regulates the proliferation, apoptosis and migration of SW480 cells by targeting MACC1. Lu M, Huang H, Yang J, Li J, Zhao G, Li W, Li X, Liu G, Wei L, Shi B, Zhao C, Fu Y. Exp Ther Med. 2019 Apr;17(4):2807-2814. doi: 10.3892/etm.2019.7260. Epub 2019 Feb 12. PubMed |
| Loss of TP63 Promotes the Metastasis of Head and Neck Squamous Cell Carcinoma by Activating MAPK and STAT3 Signaling. Lakshmanachetty S, Balaiya V, High WA, Koster MI. Mol Cancer Res. 2019 Jun;17(6):1279-1293. doi: 10.1158/1541-7786.MCR-18-1355. Epub 2019 Mar 25. PubMed |
| Production and Validation of Lentiviral Vectors for CRISPR/Cas9 Delivery. Ryo LB, Thomsen EA, Mikkelsen JG. Methods Mol Biol. 2019;1961:93-109. doi: 10.1007/978-1-4939-9170-9_7. PubMed |
| Maintenance of Nucleolar Homeostasis by CBX4 Alleviates Senescence and Osteoarthritis. Ren X, Hu B, Song M, Ding Z, Dang Y, Liu Z, Zhang W, Ji Q, Ren R, Ding J, Chan P, Jiang C, Ye K, Qu J, Tang F, Liu GH. Cell Rep. 2019 Mar 26;26(13):3643-3656.e7. doi: 10.1016/j.celrep.2019.02.088. PubMed |
| Atheroprotective Flow Upregulates ITPR3 (Inositol 1,4,5-Trisphosphate Receptor 3) in Vascular Endothelium via KLF4 (Kruppel-Like Factor 4)-Mediated Histone Modifications. He M, Huang TS, Li S, Hong HC, Chen Z, Martin M, Zhou X, Huang HY, Su SH, Zhang J, Wang WT, Kang J, Huang HD, Zhang J, Chien S, Shyy JY. Arterioscler Thromb Vasc Biol. 2019 May;39(5):902-914. doi: 10.1161/ATVBAHA.118.312301. PubMed |
| Combined Transcriptome and Proteome Analysis of Immortalized Human Keratinocytes Expressing Human Papillomavirus 16 (HPV16) Oncogenes Reveals Novel Key Factors and Networks in HPV-Induced Carcinogenesis. Yang R, Klimentova J, Gockel-Krzikalla E, Ly R, Gmelin N, Hotz-Wagenblatt A, Rehulkova H, Stulik J, Rosl F, Niebler M. mSphere. 2019 Mar 27;4(2). pii: 4/2/e00129-19. doi: 10.1128/mSphere.00129-19. PubMed |
| Syndecan 1 is a critical mediator of macropinocytosis in pancreatic cancer. Yao W, Rose JL, Wang W, Seth S, Jiang H, Taguchi A, Liu J, Yan L, Kapoor A, Hou P, Chen Z, Wang Q, Nezi L, Xu Z, Yao J, Hu B, Pettazzoni PF, Ho IL, Feng N, Ramamoorthy V, Jiang S, Deng P, Ma GJ, Den P, Tan Z, Zhang SX, Wang H, Wang YA, Deem AK, Fleming JB, Carugo A, Heffernan TP, Maitra A, Viale A, Ying H, Hanash S, DePinho RA, Draetta GF. Nature. 2019 Apr;568(7752):410-414. doi: 10.1038/s41586-019-1062-1. Epub 2019 Mar 27. PubMed |
| Chemokine (C-X-C motif) ligand 14 contributes to lipopolysaccharide-induced fibrogenesis in mouse L929 fibroblasts via modulating PPM1A. Li L, Li Q, Wei L, Wang Z, Ma W, Liu F, Shen Y, Zhang S, Zhang X, Li H, Qian Y. J Cell Biochem. 2019 Aug;120(8):13372-13381. doi: 10.1002/jcb.28612. Epub 2019 Mar 28. PubMed |
| Sex determining region Y-box 12 (SOX12) promotes gastric cancer metastasis by upregulating MMP7 and IGF1. Du F, Feng W, Chen S, Wu S, Cao T, Yuan T, Tian D, Nie Y, Wu K, Fan D, Xia L. Cancer Lett. 2019 Jun 28;452:103-118. doi: 10.1016/j.canlet.2019.03.035. Epub 2019 Mar 25. PubMed |
| Tacalcitol increases the sensitivity of colorectal cancer cells to 5-fluorouracil by downregulating the thymidylate synthase. Milczarek M, Rossowska J, Klopotowska D, Stachowicz M, Kutner A, Wietrzyk J. J Steroid Biochem Mol Biol. 2019 Jun;190:139-151. doi: 10.1016/j.jsbmb.2019.03.017. Epub 2019 Mar 25. PubMed |
| The long noncoding RNA Falcor regulates Foxa2 expression to maintain lung epithelial homeostasis and promote regeneration. Swarr DT, Herriges M, Li S, Morley M, Fernandes S, Sridharan A, Zhou S, Garcia BA, Stewart K, Morrisey EE. Genes Dev. 2019 Jun 1;33(11-12):656-668. doi: 10.1101/gad.320523.118. Epub 2019 Mar 28. PubMed |
| The homophilic receptor PTPRK selectively dephosphorylates multiple junctional regulators to promote cell-cell adhesion. Fearnley GW, Young KA, Edgar JR, Antrobus R, Hay IM, Liang WC, Martinez-Martin N, Lin W, Deane JE, Sharpe HJ. Elife. 2019 Mar 29;8. pii: 44597. doi: 10.7554/eLife.44597. PubMed |
| Progesterone receptor isoform B expression in pulmonary neuroendocrine cells decreases cell proliferation. Asavasupreechar T, Saito R, Edwards DP, Sasano H, Boonyaratanakornkit V. J Steroid Biochem Mol Biol. 2019 Jun;190:212-223. doi: 10.1016/j.jsbmb.2019.03.022. Epub 2019 Mar 26. PubMed |
| The kinase PERK and the transcription factor ATF4 play distinct and essential roles in autophagy resulting from tunicamycin-induced ER stress. Luhr M, Torgersen ML, Szalai P, Hashim A, Brech A, Staerk J, Engedal N. J Biol Chem. 2019 May 17;294(20):8197-8217. doi: 10.1074/jbc.RA118.002829. Epub 2019 Mar 29. PubMed |
| Safe and neuroprotective vectors for long-term traumatic brain injury gene therapy. Blanco-Ocampo D, Cawen FA, Alamo-Pindado LA, Negro-Demontel ML, Peluffo H. Gene Ther. 2019 Mar 29. pii: 10.1038/s41434-019-0073-8. doi: 10.1038/s41434-019-0073-8. PubMed |
| MYC Recruits SPT5 to RNA Polymerase II to Promote Processive Transcription Elongation. Baluapuri A, Hofstetter J, Dudvarski Stankovic N, Endres T, Bhandare P, Vos SM, Adhikari B, Schwarz JD, Narain A, Vogt M, Wang SY, Duster R, Jung LA, Vanselow JT, Wiegering A, Geyer M, Maric HM, Gallant P, Walz S, Schlosser A, Cramer P, Eilers M, Wolf E. Mol Cell. 2019 May 16;74(4):674-687.e11. doi: 10.1016/j.molcel.2019.02.031. Epub 2019 Mar 27. PubMed |
| A Subset of TREM2(+) Dermal Macrophages Secretes Oncostatin M to Maintain Hair Follicle Stem Cell Quiescence and Inhibit Hair Growth. Wang ECE, Dai Z, Ferrante AW, Drake CG, Christiano AM. Cell Stem Cell. 2019 Apr 4;24(4):654-669.e6. doi: 10.1016/j.stem.2019.01.011. Epub 2019 Mar 28. PubMed |
| Up-regulation of FOXD1 by YAP alleviates senescence and osteoarthritis. Fu L, Hu Y, Song M, Liu Z, Zhang W, Yu FX, Wu J, Wang S, Izpisua Belmonte JC, Chan P, Qu J, Tang F, Liu GH. PLoS Biol. 2019 Apr 1;17(4):e3000201. doi: 10.1371/journal.pbio.3000201. eCollection 2019 Apr. PubMed |
| Transcriptional Circuit Fragility Influences HIV Proviral Fate. Morton EL, Forst CV, Zheng Y, DePaula-Silva AB, Ramirez NP, Planelles V, D'Orso I. Cell Rep. 2019 Apr 2;27(1):154-171.e9. doi: 10.1016/j.celrep.2019.03.007. PubMed |
| ADAR2 mislocalization and widespread RNA editing aberrations in C9orf72-mediated ALS/FTD. Moore S, Alsop E, Lorenzini I, Starr A, Rabichow BE, Mendez E, Levy JL, Burciu C, Reiman R, Chew J, Belzil VV, W Dickson D, Robertson J, Staats KA, Ichida JK, Petrucelli L, Van Keuren-Jensen K, Sattler R. Acta Neuropathol. 2019 Jul;138(1):49-65. doi: 10.1007/s00401-019-01999-w. Epub 2019 Apr 3. PubMed |
| Silencing an insulin-induced lncRNA, LncASIR, impairs the transcriptional response to insulin signalling in adipocytes. Degirmenci U, Li J, Lim YC, Siang DTC, Lin S, Liang H, Sun L. Sci Rep. 2019 Apr 4;9(1):5608. doi: 10.1038/s41598-019-42162-5. PubMed |
| Yin Yang 1 Orchestrates a Metabolic Program Required for Both Neural Crest Development and Melanoma Formation. Varum S, Baggiolini A, Zurkirchen L, Atak ZK, Cantu C, Marzorati E, Bossart R, Wouters J, Hausel J, Tuncer E, Zingg D, Veen D, John N, Balz M, Levesque MP, Basler K, Aerts S, Zamboni N, Dummer R, Sommer L. Cell Stem Cell. 2019 Apr 4;24(4):637-653.e9. doi: 10.1016/j.stem.2019.03.011. PubMed |
| Depletion of PD-1-positive cells ameliorates autoimmune disease. Zhao P, Wang P, Dong S, Zhou Z, Cao Y, Yagita H, He X, Zheng SG, Fisher SJ, Fujinami RS, Chen M. Nat Biomed Eng. 2019 Apr;3(4):292-305. doi: 10.1038/s41551-019-0360-0. Epub 2019 Mar 4. PubMed |
| Transmembrane 4 L Six Family Member 5 Senses Arginine for mTORC1 Signaling. Jung JW, Macalino SJY, Cui M, Kim JE, Kim HJ, Song DG, Nam SH, Kim S, Choi S, Lee JW. Cell Metab. 2019 Jun 4;29(6):1306-1319.e7. doi: 10.1016/j.cmet.2019.03.005. Epub 2019 Apr 4. PubMed |
A Synthetic Gene Circuit for Self-Regulating Delivery of Biologic Drugs in Engineered Tissues.
Pferdehirt L, Ross AK, Brunger JM, Guilak F.
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Essential Gene Profiles for Human Pluripotent Stem Cells Identify Uncharacterized Genes and Substrate Dependencies.
Mair B, Tomic J, Masud SN, Tonge P, Weiss A, Usaj M, Tong AHY, Kwan JJ, Brown KR, Titus E, Atkins M, Chan KSK, Munsie L, Habsid A, Han H, Kennedy M, Cohen B, Keller G, Moffat J.
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| Thrombospondin Type 1 Domain-Containing 7A Localizes to the Slit Diaphragm and Stabilizes Membrane Dynamics of Fully Differentiated Podocytes. Herwig J, Skuza S, Sachs W, Sachs M, Failla AV, Rune G, Meyer TN, Fester L, Meyer-Schwesinger C. J Am Soc Nephrol. 2019 May;30(5):824-839. doi: 10.1681/ASN.2018090941. Epub 2019 Apr 10. PubMed |
| Lung cancer deficient in the tumor suppressor GATA4 is sensitive to TGFBR1 inhibition. Gao L, Hu Y, Tian Y, Fan Z, Wang K, Li H, Zhou Q, Zeng G, Hu X, Yu L, Zhou S, Tong X, Huang H, Chen H, Liu Q, Liu W, Zhang G, Zeng M, Zhou G, He Q, Ji H, Chen L. Nat Commun. 2019 Apr 10;10(1):1665. doi: 10.1038/s41467-019-09295-7. PubMed |
| Epigenetic and therapeutic implications of dnmt3b in temporomandibular joint osteoarthritis. Zhou Y, Chen M, O'Keefe RJ, Shen J, Li Z, Zhou J, Zhou X, Mao JJ. Am J Transl Res. 2019 Mar 15;11(3):1736-1747. eCollection 2019. PubMed |
| Development of a Synthetic 3-ketosteroid Delta(1)-dehydrogenase for the Generation of a Novel Catabolic Pathway Enabling Cholesterol Degradation in Human Cells. D'Arcy BM, Swingle MR, Schambeau L, Pannell L, Prakash A, Honkanen RE. Sci Rep. 2019 Apr 12;9(1):5969. doi: 10.1038/s41598-019-42046-8. PubMed |
| Crumbs3 is a critical factor that regulates invasion and metastasis of colon adenocarcinoma via the specific interaction with FGFR1. Iioka H, Saito K, Sakaguchi M, Tachibana T, Homma K, Kondo E. Int J Cancer. 2019 Apr 13. doi: 10.1002/ijc.32336. PubMed |
| RAB27B-activated secretion of stem-like tumor exosomes delivers the biomarker microRNA-146a-5p, which promotes tumorigenesis and associates with an immunosuppressive tumor microenvironment in colorectal cancer. Cheng WC, Liao TT, Lin CC, Yuan LE, Lan HY, Lin HH, Teng HW, Chang HC, Lin CH, Yang CY, Huang SC, Jiang JK, Yang SH, Yang MH, Hwang WL. Int J Cancer. 2019 Apr 13. doi: 10.1002/ijc.32338. PubMed |
| CEA expression heterogeneity and plasticity confer resistance to the CEA-targeting bispecific immunotherapy antibody cibisatamab (CEA-TCB) in patient-derived colorectal cancer organoids. Gonzalez-Exposito R, Semiannikova M, Griffiths B, Khan K, Barber LJ, Woolston A, Spain G, von Loga K, Challoner B, Patel R, Ranes M, Swain A, Thomas J, Bryant A, Saffery C, Fotiadis N, Guettler S, Mansfield D, Melcher A, Powles T, Rao S, Watkins D, Chau I, Matthews N, Wallberg F, Starling N, Cunningham D, Gerlinger M. J Immunother Cancer. 2019 Apr 15;7(1):101. doi: 10.1186/s40425-019-0575-3. PubMed |
| Human Pluripotency Is Initiated and Preserved by a Unique Subset of Founder Cells. Nakanishi M, Mitchell RR, Benoit YD, Orlando L, Reid JC, Shimada K, Davidson KC, Shapovalova Z, Collins TJ, Nagy A, Bhatia M. Cell. 2019 May 2;177(4):910-924.e22. doi: 10.1016/j.cell.2019.03.013. Epub 2019 Apr 11. PubMed |
| Loss of Sirtuin 1 Alters the Secretome of Breast Cancer Cells by Impairing Lysosomal Integrity. Latifkar A, Ling L, Hingorani A, Johansen E, Clement A, Zhang X, Hartman J, Fischbach C, Lin H, Cerione RA, Antonyak MA. Dev Cell. 2019 May 6;49(3):393-408.e7. doi: 10.1016/j.devcel.2019.03.011. Epub 2019 Apr 11. PubMed |
| Lentiviral Vector Platform for the Efficient Delivery of Epigenome-editing Tools into Human Induced Pluripotent Stem Cell-derived Disease Models. Tagliafierro L, Ilich E, Moncalvo M, Gu J, Sriskanda A, Grenier C, Murphy SK, Chiba-Falek O, Kantor B. J Vis Exp. 2019 Mar 29;(145). doi: 10.3791/59241. PubMed |
| HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries. Luo H, Sobh A, Vulpe CD, Brewer E, Dovat S, Qiu Y, Huang S. J Vis Exp. 2019 Mar 31;(145). doi: 10.3791/59382. PubMed |
| Establishment of an erythroid progenitor cell line capable of enucleation achieved with an inducible c-Myc vector. Mayers S, Moco PD, Maqbool T, Silva PN, Kilkenny DM, Audet J. BMC Biotechnol. 2019 Apr 15;19(1):21. doi: 10.1186/s12896-019-0515-9. PubMed |
| CCL5 promotes breast cancer recurrence through macrophage recruitment in residual tumors. Walens A, DiMarco AV, Lupo R, Kroger BR, Damrauer JS, Alvarez JV. Elife. 2019 Apr 16;8. pii: 43653. doi: 10.7554/eLife.43653. PubMed |
| gamma-Catenin-Dependent Signals Maintain BCR-ABL1(+) B Cell Acute Lymphoblastic Leukemia. Luong-Gardiol N, Siddiqui I, Pizzitola I, Jeevan-Raj B, Charmoy M, Huang Y, Irmisch A, Curtet S, Angelov GS, Danilo M, Juilland M, Bornhauser B, Thome M, Hantschel O, Chalandon Y, Cazzaniga G, Bourquin JP, Huelsken J, Held W. Cancer Cell. 2019 Apr 15;35(4):649-663.e10. doi: 10.1016/j.ccell.2019.03.005. PubMed |
| Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia. Huang Y, Su R, Sheng Y, Dong L, Dong Z, Xu H, Ni T, Zhang ZS, Zhang T, Li C, Han L, Zhu Z, Lian F, Wei J, Deng Q, Wang Y, Wunderlich M, Gao Z, Pan G, Zhong D, Zhou H, Zhang N, Gan J, Jiang H, Mulloy JC, Qian Z, Chen J, Yang CG. Cancer Cell. 2019 Apr 15;35(4):677-691.e10. doi: 10.1016/j.ccell.2019.03.006. PubMed |
| The Influenza A Virus Endoribonuclease PA-X Usurps Host mRNA Processing Machinery to Limit Host Gene Expression. Gaucherand L, Porter BK, Levene RE, Price EL, Schmaling SK, Rycroft CH, Kevorkian Y, McCormick C, Khaperskyy DA, Gaglia MM. Cell Rep. 2019 Apr 16;27(3):776-792.e7. doi: 10.1016/j.celrep.2019.03.063. PubMed |
| KLF4 activates NFkappaB signaling and esophageal epithelial inflammation via the Rho-related GTP-binding protein RHOF. Shaverdashvili K, Padlo J, Weinblatt D, Jia Y, Jiang W, Rao D, Laczko D, Whelan KA, Lynch JP, Muir AB, Katz JP. PLoS One. 2019 Apr 18;14(4):e0215746. doi: 10.1371/journal.pone.0215746. eCollection 2019. PubMed |
| Cotargeting of BCL2 with Venetoclax and MCL1 with S63845 Is Synthetically Lethal In Vivo in Relapsed Mantle Cell Lymphoma. Prukova D, Andera L, Nahacka Z, Karolova J, Svaton M, Klanova M, Havranek O, Soukup J, Svobodova K, Zemanova Z, Tuskova D, Pokorna E, Helman K, Forsterova K, Pacheco-Blanco M, Vockova P, Berkova A, Fronkova E, Trneny M, Klener P. Clin Cancer Res. 2019 Jul 15;25(14):4455-4465. doi: 10.1158/1078-0432.CCR-18-3275. Epub 2019 Apr 19. PubMed |
| miR-128 Restriction of LINE-1 (L1) Retrotransposition Is Dependent on Targeting hnRNPA1 mRNA. Fung L, Guzman H, Sevrioukov E, Idica A, Park E, Bochnakian A, Daugaard I, Jury D, Mortazavi A, Zisoulis DG, Pedersen IM. Int J Mol Sci. 2019 Apr 21;20(8). pii: ijms20081955. doi: 10.3390/ijms20081955. PubMed |
| Systematic proteomics of endogenous human cohesin reveals an interaction with diverse splicing factors and RNA-binding proteins required for mitotic progression. Kim JS, He X, Liu J, Duan Z, Kim T, Gerard J, Kim B, Pillai MM, Lane WS, Noble WS, Budnik B, Waldman T. J Biol Chem. 2019 May 31;294(22):8760-8772. doi: 10.1074/jbc.RA119.007832. Epub 2019 Apr 22. PubMed |
| A novel retroviral vector system to analyze expression from mRNA with retained introns using fluorescent proteins and flow cytometry. Jackson PEH, Huang J, Sharma M, Rasmussen SK, Hammarskjold ML, Rekosh D. Sci Rep. 2019 Apr 23;9(1):6467. doi: 10.1038/s41598-019-42914-3. PubMed |
| Insulin Induces Microtubule Stabilization and Regulates the Microtubule Plus-end Tracking Protein Network in Adipocytes. Parker SS, Krantz J, Kwak EA, Barker NK, Deer CG, Lee NY, Mouneimne G, Langlais PR. Mol Cell Proteomics. 2019 Jul;18(7):1363-1381. doi: 10.1074/mcp.RA119.001450. Epub 2019 Apr 24. PubMed |
| JUND regulates pancreatic beta cell survival during metabolic stress. Good AL, Cannon CE, Haemmerle MW, Yang J, Stanescu DE, Doliba NM, Birnbaum MJ, Stoffers DA. Mol Metab. 2019 Jul;25:95-106. doi: 10.1016/j.molmet.2019.04.007. Epub 2019 Apr 11. PubMed |
| Chemical suppression of specific C-C chemokine signaling pathways enhances cardiac reprogramming. Guo Y, Lei I, Tian S, Gao W, Hacer K, Li Y, Wang S, Liu L, Wang Z. J Biol Chem. 2019 Jun 7;294(23):9134-9146. doi: 10.1074/jbc.RA118.006000. Epub 2019 Apr 25. PubMed |
| Optogenetic Monitoring of the Glutathione Redox State in Engineered Human Myocardium. Trautsch I, Heta E, Soong PL, Levent E, Nikolaev VO, Bogeski I, Katschinski DM, Mayr M, Zimmermann WH. Front Physiol. 2019 Apr 4;10:272. doi: 10.3389/fphys.2019.00272. eCollection 2019. PubMed |
| CRISPR Activation Enhances In Vitro Potency of AAV Vectors Driven by Tissue-Specific Promoters. McDougald DS, Duong TT, Palozola KC, Marsh A, Papp TE, Mills JA, Zhou S, Bennett J. Mol Ther Methods Clin Dev. 2019 Mar 28;13:380-389. doi: 10.1016/j.omtm.2019.03.004. eCollection 2019 Jun 14. PubMed |
| CRISPR/Cas9-generated mouse model of Duchenne muscular dystrophy recapitulating a newly identified large 430 kb deletion in the human DMD gene. Egorova TV, Zotova ED, Reshetov DA, Polikarpova AV, Vassilieva SG, Vlodavets DV, Gavrilov AA, Ulianov SV, Buchman VL, Deykin AV. Dis Model Mech. 2019 Apr 25;12(4). pii: 12/4/dmm037655. doi: 10.1242/dmm.037655. PubMed |
| FKBP12 mediates necroptosis by initiating RIPK1-RIPK3-MLKL signal transduction in response to TNF receptor 1 ligation. Wang Z, Feng J, Yu J, Chen G. J Cell Sci. 2019 May 20;132(10). pii: jcs.227777. doi: 10.1242/jcs.227777. PubMed |
| GemC1 governs multiciliogenesis through direct interaction with and transcriptional regulation of p73. Lalioti ME, Arbi M, Loukas I, Kaplani K, Kalogeropoulou A, Lokka G, Kyrousi C, Mizi A, Georgomanolis T, Josipovic N, Gkikas D, Benes V, Politis PK, Papantonis A, Lygerou Z, Taraviras S. J Cell Sci. 2019 Jun 3;132(11). pii: jcs.228684. doi: 10.1242/jcs.228684. PubMed |
| CRISPR Screening in Single Cells. Henriksson J. Methods Mol Biol. 2019;1979:395-406. doi: 10.1007/978-1-4939-9240-9_23. PubMed |
Hypoxia Rescues Frataxin Loss by Restoring Iron Sulfur Cluster Biogenesis.
Ast T, Meisel JD, Patra S, Wang H, Grange RMH, Kim SH, Calvo SE, Orefice LL, Nagashima F, Ichinose F, Zapol WM, Ruvkun G, Barondeau DP, Mootha VK.
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| METTL1 Promotes let-7 MicroRNA Processing via m7G Methylation. Pandolfini L, Barbieri I, Bannister AJ, Hendrick A, Andrews B, Webster N, Murat P, Mach P, Brandi R, Robson SC, Migliori V, Alendar A, d'Onofrio M, Balasubramanian S, Kouzarides T. Mol Cell. 2019 Jun 20;74(6):1278-1290.e9. doi: 10.1016/j.molcel.2019.03.040. Epub 2019 Apr 25. PubMed |
| Case Study: Mechanism for Increased Follicular Helper T Cell Development in Activated PI3K Delta Syndrome. Thauland TJ, Pellerin L, Ohgami RS, Bacchetta R, Butte MJ. Front Immunol. 2019 Apr 12;10:753. doi: 10.3389/fimmu.2019.00753. eCollection 2019. PubMed |
| Epigenetic regulation of mammalian Hedgehog signaling to the stroma determines the molecular subtype of bladder cancer. Kim S, Kim Y, Kong J, Kim E, Choi JH, Yuk HD, Lee H, Kim HR, Lee KH, Kang M, Roe JS, Moon KC, Kim S, Ku JH, Shin K. Elife. 2019 Apr 30;8. pii: 43024. doi: 10.7554/eLife.43024. PubMed |
| Influence of SHH/GLI1 axis on EMT mediated migration and invasion of breast cancer cells. Riaz SK, Ke Y, Wang F, Kayani MA, Malik MFA. Sci Rep. 2019 Apr 29;9(1):6620. doi: 10.1038/s41598-019-43093-x. PubMed |
| MRPS25 mutations impair mitochondrial translation and cause encephalomyopathy. Bugiardini E, Mitchell AL, Rosa ID, Horning-Do HT, Pitmann A, Poole OV, Holton JL, Shah S, Woodward C, Hargreaves I, Quinlivan R, Amunts A, Wiesner RJ, Houlden H, Holt IJ, Hanna MG, Pitceathly RDS, Spinazzola A. Hum Mol Genet. 2019 Apr 30. pii: 5482278. doi: 10.1093/hmg/ddz093. PubMed |
| Lysosomal proteome analysis reveals that CLN3-defective cells have multiple enzyme deficiencies associated with changes in intracellular trafficking. Schmidtke C, Tiede S, Thelen M, Kakela R, Jabs S, Makrypidi G, Sylvester M, Schweizer M, Braren I, Brocke-Ahmadinejad N, Cotman SL, Schulz A, Gieselmann V, Braulke T. J Biol Chem. 2019 Jun 14;294(24):9592-9604. doi: 10.1074/jbc.RA119.008852. Epub 2019 Apr 30. PubMed |
| CD13 tethers the IQGAP1-ARF6-EFA6 complex to the plasma membrane to promote ARF6 activation, beta1 integrin recycling, and cell migration. Ghosh M, Lo R, Ivic I, Aguilera B, Qendro V, Devarakonda C, Shapiro LH. Sci Signal. 2019 Apr 30;12(579). pii: 12/579/eaav5938. doi: 10.1126/scisignal.aav5938. PubMed |
| Inhibition of MYC by the SMARCB1 tumor suppressor. Weissmiller AM, Wang J, Lorey SL, Howard GC, Martinez E, Liu Q, Tansey WP. Nat Commun. 2019 May 1;10(1):2014. doi: 10.1038/s41467-019-10022-5. PubMed |
| Mitochondrial ClpP-Mediated Proteolysis Induces Selective Cancer Cell Lethality. Ishizawa J, Zarabi SF, Davis RE, Halgas O, Nii T, Jitkova Y, Zhao R, St-Germain J, Heese LE, Egan G, Ruvolo VR, Barghout SH, Nishida Y, Hurren R, Ma W, Gronda M, Link T, Wong K, Mabanglo M, Kojima K, Borthakur G, MacLean N, Ma MCJ, Leber AB, Minden MD, Houry W, Kantarjian H, Stogniew M, Raught B, Pai EF, Schimmer AD, Andreeff M. Cancer Cell. 2019 May 13;35(5):721-737.e9. doi: 10.1016/j.ccell.2019.03.014. Epub 2019 May 2. PubMed |
| Chemoproteomic Profiling Uncovers CDK4-Mediated Phosphorylation of the Translational Suppressor 4E-BP1. Mitchell DC, Menon A, Garner AL. Cell Chem Biol. 2019 Jul 18;26(7):980-990.e8. doi: 10.1016/j.chembiol.2019.03.012. Epub 2019 May 2. PubMed |
| Genome-Wide CRISPR Screening Identifies the Tumor Suppressor Candidate OVCA2 As a Determinant of Tolerance to Acetaldehyde. Sobh A, Loguinov A, Stornetta A, Balbo S, Tagmount A, Zhang L, Vulpe CD. Toxicol Sci. 2019 May 1;169(1):235-245. doi: 10.1093/toxsci/kfz037. PubMed |
| BIRC5 is a target for molecular imaging and detection of human pancreatic cancer. Liu SH, Hong Y, Markowiak S, Sanchez R, Creeden J, Nemunaitis J, Kalinoski A, Willey J, Erhardt P, Lee J, van Dam M, Brunicardi FC. Cancer Lett. 2019 Aug 10;457:10-19. doi: 10.1016/j.canlet.2019.04.036. Epub 2019 May 3. PubMed |
| Inhibiting pathologically active ADAM10 rescues synaptic and cognitive decline in Huntington's disease. Vezzoli E, Caron I, Talpo F, Besusso D, Conforti P, Battaglia E, Sogne E, Falqui A, Petricca L, Verani M, Martufi P, Caricasole A, Bresciani A, Cecchetti O, Rivetti di Val Cervo P, Sancini G, Riess O, Nguyen H, Seipold L, Saftig P, Biella G, Cattaneo E, Zuccato C. J Clin Invest. 2019 May 6;130:2390-2403. doi: 10.1172/JCI120616. eCollection 2019 May 6. PubMed |
| Deficiency of stress-associated gene Nupr1 increases bone volume by attenuating differentiation of osteoclasts and enhancing differentiation of osteoblasts. Shiraki M, Xu X, Iovanna JL, Kukita T, Hirata H, Kamohara A, Kubota Y, Miyamoto H, Mawatari M, Kukita A. FASEB J. 2019 Aug;33(8):8836-8852. doi: 10.1096/fj.201802322RR. Epub 2019 May 8. PubMed |
| The ER Membrane Protein Complex Promotes Biogenesis of Dengue and Zika Virus Non-structural Multi-pass Transmembrane Proteins to Support Infection. Lin DL, Inoue T, Chen YJ, Chang A, Tsai B, Tai AW. Cell Rep. 2019 May 7;27(6):1666-1674.e4. doi: 10.1016/j.celrep.2019.04.051. PubMed |
| Effects of histone deacetylase inhibitor Scriptaid and parathyroid hormone on osteocyte functions and metabolism. Sun N, Uda Y, Azab E, Kochen A, Santos RNCE, Shi C, Kobayashi T, Wein MN, Divieti Pajevic P. J Biol Chem. 2019 Jun 21;294(25):9722-9733. doi: 10.1074/jbc.RA118.007312. Epub 2019 May 8. PubMed |
| HDAC1,2 Knock-Out and HDACi Induced Cell Apoptosis in Imatinib-Resistant K562 Cells. Chen SH, Chow JM, Hsieh YY, Lin CY, Hsu KW, Hsieh WS, Chi WM, Shabangu BM, Lee CH. Int J Mol Sci. 2019 May 8;20(9). pii: ijms20092271. doi: 10.3390/ijms20092271. PubMed |
| Sox17 is required for endothelial regeneration following inflammation-induced vascular injury. Liu M, Zhang L, Marsboom G, Jambusaria A, Xiong S, Toth PT, Benevolenskaya EV, Rehman J, Malik AB. Nat Commun. 2019 May 9;10(1):2126. doi: 10.1038/s41467-019-10134-y. PubMed |
| CCAAT/enhancer binding protein delta (C/EBPdelta) demonstrates a dichotomous role in tumour initiation and promotion of epithelial carcinoma. Sowamber R, Chehade R, Bitar M, Dodds LV, Milea A, Slomovitz B, Shaw PA, George SHL. EBioMedicine. 2019 Jun;44:261-274. doi: 10.1016/j.ebiom.2019.05.002. Epub 2019 May 9. PubMed |
| Identification of Cancer Drivers at CTCF Insulators in 1,962 Whole Genomes. Liu EM, Martinez-Fundichely A, Diaz BJ, Aronson B, Cuykendall T, MacKay M, Dhingra P, Wong EWP, Chi P, Apostolou E, Sanjana NE, Khurana E. Cell Syst. 2019 May 22;8(5):446-455.e8. doi: 10.1016/j.cels.2019.04.001. Epub 2019 May 8. PubMed |
| Targeted therapy based on p53 reactivation reduces both glioblastoma cell growth and resistance to temozolomide. Forte IM, Indovina P, Iannuzzi CA, Cirillo D, Di Marzo D, Barone D, Capone F, Pentimalli F, Giordano A. Int J Oncol. 2019 Jun;54(6):2189-2199. doi: 10.3892/ijo.2019.4788. Epub 2019 Apr 16. PubMed |
| The long noncoding RNA TP73-AS1 promotes tumorigenicity of medulloblastoma cells. Varon M, Levy T, Mazor G, Ben David H, Marciano R, Krelin Y, Prasad M, Elkabets M, Pauck D, Ahmadov U, Picard D, Qin N, Borkhardt A, Reifenberger G, Leprivier G, Remke M, Rotblat B. Int J Cancer. 2019 May 13. doi: 10.1002/ijc.32400. PubMed |
| A 3D culture model of innervated human skeletal muscle enables studies of the adult neuromuscular junction. Afshar Bakooshli M, Lippmann ES, Mulcahy B, Iyer N, Nguyen CT, Tung K, Stewart BA, van den Dorpel H, Fuehrmann T, Shoichet M, Bigot A, Pegoraro E, Ahn H, Ginsberg H, Zhen M, Ashton RS, Gilbert PM. Elife. 2019 May 14;8. pii: 44530. doi: 10.7554/eLife.44530. PubMed |
| A standard procedure for lentiviral-mediated labeling of murine mesenchymal stromal cells in vitro. Lupan AM, Preda MB, Burlacu A. Biotechnol Appl Biochem. 2019 May 14. doi: 10.1002/bab.1765. PubMed |
| MEIS1 knockdown may promote differentiation of esophageal squamous carcinoma cell line KYSE-30. Mahmoudian RA, Bahadori B, Rad A, Abbaszadegan MR, Forghanifard MM. Mol Genet Genomic Med. 2019 Jul;7(7):e00746. doi: 10.1002/mgg3.746. Epub 2019 May 14. PubMed |
| c-FLIP and CD95 signaling are essential for survival of renal cell carcinoma. Luebke T, Schwarz L, Beer YY, Schumann S, Misterek M, Sander FE, Plaza-Sirvent C, Schmitz I. Cell Death Dis. 2019 May 16;10(6):384. doi: 10.1038/s41419-019-1609-y. PubMed |
| MEK inhibitors activate Wnt signalling and induce stem cell plasticity in colorectal cancer. Zhan T, Ambrosi G, Wandmacher AM, Rauscher B, Betge J, Rindtorff N, Haussler RS, Hinsenkamp I, Bamberg L, Hessling B, Muller-Decker K, Erdmann G, Burgermeister E, Ebert MP, Boutros M. Nat Commun. 2019 May 16;10(1):2197. doi: 10.1038/s41467-019-09898-0. PubMed |
| Longitudinal Analysis of the Human B Cell Response to Ebola Virus Infection. Davis CW, Jackson KJL, McElroy AK, Halfmann P, Huang J, Chennareddy C, Piper AE, Leung Y, Albarino CG, Crozier I, Ellebedy AH, Sidney J, Sette A, Yu T, Nielsen SCA, Goff AJ, Spiropoulou CF, Saphire EO, Cavet G, Kawaoka Y, Mehta AK, Glass PJ, Boyd SD, Ahmed R. Cell. 2019 May 30;177(6):1566-1582.e17. doi: 10.1016/j.cell.2019.04.036. Epub 2019 May 16. PubMed |
| Human Neonatal Fc Receptor Is the Cellular Uncoating Receptor for Enterovirus B. Zhao X, Zhang G, Liu S, Chen X, Peng R, Dai L, Qu X, Li S, Song H, Gao Z, Yuan P, Liu Z, Li C, Shang Z, Li Y, Zhang M, Qi J, Wang H, Du N, Wu Y, Bi Y, Gao S, Shi Y, Yan J, Zhang Y, Xie Z, Wei W, Gao GF. Cell. 2019 May 30;177(6):1553-1565.e16. doi: 10.1016/j.cell.2019.04.035. Epub 2019 May 16. PubMed |
| TNF-alpha/IL-1beta-licensed mesenchymal stromal cells promote corneal allograft survival via myeloid cell-mediated induction of Foxp3(+) regulatory T cells in the lung. Murphy N, Treacy O, Lynch K, Morcos M, Lohan P, Howard L, Fahy G, Griffin MD, Ryan AE, Ritter T. FASEB J. 2019 Aug;33(8):9404-9421. doi: 10.1096/fj.201900047R. Epub 2019 May 20. PubMed |
| Aberrant methylation status of SPG20 promoter in hepatocellular carcinoma: A potential tumor metastasis biomarker. He L, Fan X, Li Y, Cui B, Shi Z, Zhou D, Lin H. Cancer Genet. 2019 Apr;233-234:48-55. doi: 10.1016/j.cancergen.2019.04.003. Epub 2019 Apr 12. PubMed |
| Parenchymal and stromal tissue regeneration of tooth organ by pivotal signals reinstated in decellularized matrix. He L, Zhou J, Chen M, Lin CS, Kim SG, Zhou Y, Xiang L, Xie M, Bai H, Yao H, Shi C, Coelho PG, Bromage TG, Hu B, Tovar N, Witek L, Wu J, Chen K, Gu W, Zheng J, Sheu TJ, Zhong J, Wen J, Niu Y, Cheng B, Gong Q, Owens DM, Stanislauskas M, Pei J, Chotkowski G, Wang S, Yang G, Zegarelli DJ, Shi X, Finkel M, Zhang W, Li J, Cheng J, Tarnow DP, Zhou X, Wang Z, Jiang X, Romanov A, Rowe DW, Wang S, Ye L, Ling J, Mao J. Nat Mater. 2019 Jun;18(6):627-637. doi: 10.1038/s41563-019-0368-6. Epub 2019 May 21. PubMed |
| Mitohormesis Primes Tumor Invasion and Metastasis. Kenny TC, Craig AJ, Villanueva A, Germain D. Cell Rep. 2019 May 21;27(8):2292-2303.e6. doi: 10.1016/j.celrep.2019.04.095. PubMed |
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| A conserved PLPLRT/SD motif of STING mediates the recruitment and activation of TBK1. Zhao B, Du F, Xu P, Shu C, Sankaran B, Bell SL, Liu M, Lei Y, Gao X, Fu X, Zhu F, Liu Y, Laganowsky A, Zheng X, Ji JY, West AP, Watson RO, Li P. Nature. 2019 May;569(7758):718-722. doi: 10.1038/s41586-019-1228-x. Epub 2019 May 22. PubMed |
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| EMSY expression affects multiple components of the skin barrier with relevance to atopic dermatitis. Elias MS, Wright SC, Remenyi J, Abbott JC, Bray SE, Cole C, Edwards S, Gierlinski M, Glok M, McGrath JA, Nicholson WV, Paternoster L, Prescott AR, Have ST, Whitfield PD, Lamond AI, Brown SJ. J Allergy Clin Immunol. 2019 May 31. pii: S0091-6749(19)30741-9. doi: 10.1016/j.jaci.2019.05.024. PubMed |
| Discovery of a Pathogenic Variant rs139379666 (p. P2974L) in ATM for Breast Cancer Risk in Chinese Populations. Guo X, Lin W, Bai M, Li H, Wen W, Zeng C, Chen Z, He J, Chen J, Cai Q, Long J, Jia WH, Shu XO, Zheng W. Cancer Epidemiol Biomarkers Prev. 2019 Aug;28(8):1308-1315. doi: 10.1158/1055-9965.EPI-18-1294. Epub 2019 Jun 3. PubMed |
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| The length of guide RNA and target DNA heteroduplex effects on CRISPR/Cas9 mediated genome editing efficiency in porcine cells. Lv J, Wu S, Wei R, Li Y, Jin J, Mu Y, Zhang Y, Kong Q, Weng X, Liu Z. J Vet Sci. 2019 May;20(3):e23. doi: 10.4142/jvs.2019.20.e23. PubMed |
| The Effect of FERMT1 Regulated by miR-24 on the Growth and Radiation Resistance of Esophageal Cancer. Yan Q, Chen T, Yang H, Yu H, Zheng Y, He T, Wang J. J Biomed Nanotechnol. 2019 Mar 1;15(3):621-631. doi: 10.1166/jbn.2019.2711. PubMed |
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| Clustered telomeres in phase-separated nuclear condensates engage mitotic DNA synthesis through BLM and RAD52. Min J, Wright WE, Shay JW. Genes Dev. 2019 Jul 1;33(13-14):814-827. doi: 10.1101/gad.324905.119. Epub 2019 Jun 6. PubMed |
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| Embryonic Chimeras with Human Pluripotent Stem Cells. De Los Angeles A, Sakurai M, Wu J. Methods Mol Biol. 2019;2005:125-151. doi: 10.1007/978-1-4939-9524-0_9. PubMed |
| Metabolic stress activates an ERK/hnRNPK/DDX3X pathway in pancreatic beta cells. Good AL, Haemmerle MW, Oguh AU, Doliba NM, Stoffers DA. Mol Metab. 2019 Aug;26:45-56. doi: 10.1016/j.molmet.2019.05.009. Epub 2019 May 24. PubMed |
| Symbiotic Macrophage-Glioma Cell Interactions Reveal Synthetic Lethality in PTEN-Null Glioma. Chen P, Zhao D, Li J, Liang X, Li J, Chang A, Henry VK, Lan Z, Spring DJ, Rao G, Wang YA, DePinho RA. Cancer Cell. 2019 Jun 10;35(6):868-884.e6. doi: 10.1016/j.ccell.2019.05.003. PubMed |
| Extensive Epitranscriptomic Methylation of A and C Residues on Murine Leukemia Virus Transcripts Enhances Viral Gene Expression. Courtney DG, Chalem A, Bogerd HP, Law BA, Kennedy EM, Holley CL, Cullen BR. MBio. 2019 Jun 11;10(3). pii: mBio.01209-19. doi: 10.1128/mBio.01209-19. PubMed |
| KMT5A promotes metastasis of clear cell renal cell carcinoma through reducing cadherin-1 expression. Lin ZZ, Ming DS, Chen YB, Zhang JM, Chen HH, Jiang JJ, Zhang ZS. Oncol Lett. 2019 Jun;17(6):4907-4913. doi: 10.3892/ol.2019.10163. Epub 2019 Mar 19. PubMed |
| Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome. Sharif H, Wang L, Wang WL, Magupalli VG, Andreeva L, Qiao Q, Hauenstein AV, Wu Z, Nunez G, Mao Y, Wu H. Nature. 2019 Jun;570(7761):338-343. doi: 10.1038/s41586-019-1295-z. Epub 2019 Jun 12. PubMed |
| Self-assembled nanofibrils from RGD-functionalized cellulose nanocrystals to improve the performance of PEI/DNA polyplexes. Hujaya SD, Manninen A, Kling K, Wagner JB, Vainio SJ, Liimatainen H. J Colloid Interface Sci. 2019 Jun 3;553:71-82. doi: 10.1016/j.jcis.2019.06.001. PubMed |
| MHC-I peptide binding activity assessed by exchange after cleavage of peptide covalently linked to beta2-microglobulin. Jurewicz MM, Willis RA, Altman JD, Stern LJ. Anal Biochem. 2019 Jun 12. pii: S0003-2697(19)30180-0. doi: 10.1016/j.ab.2019.05.017. PubMed |
| Abundance of d-2-hydroxyglutarate in G2/M is determined by FOXM1 in mutant IDH1-expressing cells. Bala Bhaskara Rao K, Katragunta K, Sarma UM, Jain N. FEBS Lett. 2019 Jun 18. doi: 10.1002/1873-3468.13500. PubMed |
| p73 regulates epidermal wound healing and induced keratinocyte programming. Beeler JS, Marshall CB, Gonzalez-Ericsson PI, Shaver TM, Santos Guasch GL, Lea ST, Johnson KN, Jin H, Venters BJ, Sanders ME, Pietenpol JA. PLoS One. 2019 Jun 19;14(6):e0218458. doi: 10.1371/journal.pone.0218458. eCollection 2019. PubMed |
| Enhancement of LIN28B-induced hematopoietic reprogramming by IGF2BP3. Wang S, Chim B, Su Y, Khil P, Wong M, Wang X, Foroushani A, Smith PT, Liu X, Li R, Ganesan S, Kanellopoulou C, Hafner M, Muljo SA. Genes Dev. 2019 Aug 1;33(15-16):1048-1068. doi: 10.1101/gad.325100.119. Epub 2019 Jun 20. PubMed |
| DEPTOR induces a partial epithelial-to-mesenchymal transition and metastasis via autocrine TGFbeta1 signaling and is associated with poor prognosis in hepatocellular carcinoma. Chen J, Zhu H, Liu Q, Ning D, Zhang Z, Zhang L, Mo J, Du P, Liu X, Song S, Fan Y, Liang H, Liu J, Zhang B, Chen X. J Exp Clin Cancer Res. 2019 Jun 22;38(1):273. doi: 10.1186/s13046-019-1220-1. PubMed |
| An Oxygen-Dependent Interaction between FBXL5 and the CIA-Targeting Complex Regulates Iron Homeostasis. Mayank AK, Pandey V, Vashisht AA, Barshop WD, Rayatpisheh S, Sharma T, Haque T, Powers DN, Wohlschlegel JA. Mol Cell. 2019 Jul 25;75(2):382-393.e5. doi: 10.1016/j.molcel.2019.05.020. Epub 2019 Jun 19. PubMed |
| Zika virus NS5 protein inhibits cell growth and invasion of glioma. Li H, Hu Y, Huang J, Feng Y, Zhang Z, Zhong K, Chen Y, Wang Z, Huang C, Yang H, Tong A. Biochem Biophys Res Commun. 2019 Aug 20;516(2):515-520. doi: 10.1016/j.bbrc.2019.06.064. Epub 2019 Jun 20. PubMed |
Single-Cell Transcriptomic Analyses of Cell Fate Transitions during Human Cardiac Reprogramming.
Zhou Y, Liu Z, Welch JD, Gao X, Wang L, Garbutt T, Keepers B, Ma H, Prins JF, Shen W, Liu J, Qian L.
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| High-throughput multicolor optogenetics in microwell plates. Bugaj LJ, Lim WA. Nat Protoc. 2019 Jul;14(7):2205-2228. doi: 10.1038/s41596-019-0178-y. Epub 2019 Jun 24. PubMed |
| Pancreatic Ductal Organoids React Kras Dependent to the Removal of Tumor Suppressive Roadblocks. Perkhofer L, Engler M, Gout J, Arnold F, Morawe M, Breunig M, Seufferlein T, Kleger A, Frappart PO. Stem Cells Int. 2019 May 19;2019:2079742. doi: 10.1155/2019/2079742. eCollection 2019. PubMed |
| Alcohol Effects on Colon Epithelium are Time-Dependent. Bishehsari F, Zhang L, Voigt RM, Maltby N, Semsarieh B, Zorub E, Shaikh M, Wilber S, Armstrong AR, Mirbagheri SS, Preite NZ, Song P, Stornetta A, Balbo S, Forsyth CB, Keshavarzian A. Alcohol Clin Exp Res. 2019 Jun 25. doi: 10.1111/acer.14141. PubMed |
| CELF2 suppresses non-small cell lung carcinoma growth by inhibiting the PREX2-PTEN interaction. Yeung YT, Fan S, Lu B, Yin S, Yang S, Nie W, Wang M, Zhou L, Li T, Li X, Bode AM, Dong Z. Carcinogenesis. 2019 Jun 25. pii: 5523300. doi: 10.1093/carcin/bgz113. PubMed |
| Loss of the transcription factor RBPJ induces disease-promoting properties in brain pericytes. Dieguez-Hurtado R, Kato K, Giaimo BD, Nieminen-Kelha M, Arf H, Ferrante F, Bartkuhn M, Zimmermann T, Bixel MG, Eilken HM, Adams S, Borggrefe T, Vajkoczy P, Adams RH. Nat Commun. 2019 Jun 27;10(1):2817. doi: 10.1038/s41467-019-10643-w. PubMed |
| Nutrient availability shapes methionine metabolism in p16/MTAP-deleted cells. Sanderson SM, Mikhael PG, Ramesh V, Dai Z, Locasale JW. Sci Adv. 2019 Jun 26;5(6):eaav7769. doi: 10.1126/sciadv.aav7769. eCollection 2019 Jun. PubMed |
| Establishment of a system for screening autophagic flux regulators using a modified fluorescent reporter and CRISPR/Cas9. Yazawa R, Nishida Y, Aoyama S, Tanida I, Miyatsuka T, Suzuki L, Himuro M, Haruna H, Takubo N, Shimizu T, Watada H. Biochem Biophys Res Commun. 2019 Aug 27;516(3):686-692. doi: 10.1016/j.bbrc.2019.06.129. Epub 2019 Jun 26. PubMed |
WDFY2 restrains matrix metalloproteinase secretion and cell invasion by controlling VAMP3-dependent recycling.
Sneeggen M, Pedersen NM, Campsteijn C, Haugsten EM, Stenmark H, Schink KO.
Nat Commun. 2019 Jun 28;10(1):2850. doi: 10.1038/s41467-019-10794-w.
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| Mitophagy Failure in APP and Tau Overexpression Model of Alzheimer's Disease. Martin-Maestro P, Gargini R, Garcia E, Simon D, Avila J, Garcia-Escudero V. J Alzheimers Dis. 2019;70(2):525-540. doi: 10.3233/JAD-190086. PubMed |
| BACH1 Stabilization by Antioxidants Stimulates Lung Cancer Metastasis. Wiel C, Le Gal K, Ibrahim MX, Jahangir CA, Kashif M, Yao H, Ziegler DV, Xu X, Ghosh T, Mondal T, Kanduri C, Lindahl P, Sayin VI, Bergo MO. Cell. 2019 Jul 11;178(2):330-345.e22. doi: 10.1016/j.cell.2019.06.005. Epub 2019 Jun 27. PubMed |
| Functional Relevance of Interleukin-1 Receptor Inter-domain Flexibility for Cytokine Binding and Signaling. Ge J, Remesh SG, Hammel M, Pan S, Mahan AD, Wang S, Wang X. Structure. 2019 Aug 6;27(8):1296-1307.e5. doi: 10.1016/j.str.2019.05.011. Epub 2019 Jun 27. PubMed |
| Bmi1 Suppresses Adipogenesis in the Hematopoietic Stem Cell Niche. Hu T, Kitano A, Luu V, Dawson B, Hoegenauer KA, Lee BH, Nakada D. Stem Cell Reports. 2019 Sep 10;13(3):545-558. doi: 10.1016/j.stemcr.2019.05.027. Epub 2019 Jun 27. PubMed |
| SNAI2 3'untranslated region promotes the invasion of ovarian cancer cells by inducing MARCKS expression. Li J, Wang J, Yue H, Lu X. J Cancer. 2019 Jun 2;10(11):2480-2487. doi: 10.7150/jca.29489. eCollection 2019. PubMed |
| An ErbB2/c-Src axis links bioenergetics with PRC2 translation to drive epigenetic reprogramming and mammary tumorigenesis. Smith HW, Hirukawa A, Sanguin-Gendreau V, Nandi I, Dufour CR, Zuo D, Tandoc K, Leibovitch M, Singh S, Rennhack JP, Swiatnicki M, Lavoie C, Papavasiliou V, Temps C, Carragher NO, Unciti-Broceta A, Savage P, Basik M, van Hoef V, Larsson O, Cooper CL, Vargas Calderon AC, Beith J, Millar E, Selinger C, Giguere V, Park M, Harris LN, Varadan V, Andrechek ER, O'Toole SA, Topisirovic I, Muller WJ. Nat Commun. 2019 Jul 1;10(1):2901. doi: 10.1038/s41467-019-10681-4. PubMed |
Human GBP1 is a microbe-specific gatekeeper of macrophage apoptosis and pyroptosis.
Fisch D, Bando H, Clough B, Hornung V, Yamamoto M, Shenoy AR, Frickel EM.
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| Neuronal Soma-Derived Degradative Lysosomes Are Continuously Delivered to Distal Axons to Maintain Local Degradation Capacity. Farfel-Becker T, Roney JC, Cheng XT, Li S, Cuddy SR, Sheng ZH. Cell Rep. 2019 Jul 2;28(1):51-64.e4. doi: 10.1016/j.celrep.2019.06.013. PubMed |
| The metalloproteinase ADAM15 is upregulated by shear stress and promotes survival of endothelial cells. Babendreyer A, Molls L, Simons IM, Dreymueller D, Biller K, Jahr H, Denecke B, Boon RA, Bette S, Schnakenberg U, Ludwig A. J Mol Cell Cardiol. 2019 Jul 1;134:51-61. doi: 10.1016/j.yjmcc.2019.06.017. PubMed |
| Targeting hypoxia downstream signaling protein, CAIX, for CAR T-cell therapy against glioblastoma. Cui J, Zhang Q, Song Q, Wang H, Dmitriev P, Sun MY, Cao X, Wang Y, Guo L, Indig IH, Rosenblum JS, Ji C, Cao D, Yang K, Gilbert MR, Yao Y, Zhuang Z. Neuro Oncol. 2019 Nov 4;21(11):1436-1446. doi: 10.1093/neuonc/noz117. PubMed |
| Identification of the m(6)Am Methyltransferase PCIF1 Reveals the Location and Functions of m(6)Am in the Transcriptome. Boulias K, Toczydlowska-Socha D, Hawley BR, Liberman N, Takashima K, Zaccara S, Guez T, Vasseur JJ, Debart F, Aravind L, Jaffrey SR, Greer EL. Mol Cell. 2019 Jun 20. pii: S1097-2765(19)30439-3. doi: 10.1016/j.molcel.2019.06.006. PubMed |
| PCIF1 Catalyzes m6Am mRNA Methylation to Regulate Gene Expression. Sendinc E, Valle-Garcia D, Dhall A, Chen H, Henriques T, Navarrete-Perea J, Sheng W, Gygi SP, Adelman K, Shi Y. Mol Cell. 2019 Jun 18. pii: S1097-2765(19)30402-2. doi: 10.1016/j.molcel.2019.05.030. PubMed |
| Forkhead box K2 promotes human colorectal cancer metastasis by upregulating ZEB1 and EGFR. Du F, Qiao C, Li X, Chen Z, Liu H, Wu S, Hu S, Qiu Z, Qian M, Tian D, Wu K, Fan D, Nie Y, Xia L. Theranostics. 2019 May 31;9(13):3879-3902. doi: 10.7150/thno.31716. eCollection 2019. PubMed |
| Covalent targeting of the vacuolar H(+)-ATPase activates autophagy via mTORC1 inhibition. Chung CY, Shin HR, Berdan CA, Ford B, Ward CC, Olzmann JA, Zoncu R, Nomura DK. Nat Chem Biol. 2019 Aug;15(8):776-785. doi: 10.1038/s41589-019-0308-4. Epub 2019 Jul 8. PubMed |
| Genomic and Transcriptomic Determinants of Therapy Resistance and Immune Landscape Evolution during Anti-EGFR Treatment in Colorectal Cancer. Woolston A, Khan K, Spain G, Barber LJ, Griffiths B, Gonzalez-Exposito R, Hornsteiner L, Punta M, Patil Y, Newey A, Mansukhani S, Davies MN, Furness A, Sclafani F, Peckitt C, Jimenez M, Kouvelakis K, Ranftl R, Begum R, Rana I, Thomas J, Bryant A, Quezada S, Wotherspoon A, Khan N, Fotiadis N, Marafioti T, Powles T, Lise S, Calvo F, Guettler S, von Loga K, Rao S, Watkins D, Starling N, Chau I, Sadanandam A, Cunningham D, Gerlinger M. Cancer Cell. 2019 Jul 8;36(1):35-50.e9. doi: 10.1016/j.ccell.2019.05.013. PubMed |
| Conserved Herpesvirus Protein Kinases Target SAMHD1 to Facilitate Virus Replication. Zhang K, Lv DW, Li R. Cell Rep. 2019 Jul 9;28(2):449-459.e5. doi: 10.1016/j.celrep.2019.04.020. PubMed |
| Quantitative characterization of 3D bioprinted structural elements under cell generated forces. Morley CD, Ellison ST, Bhattacharjee T, O'Bryan CS, Zhang Y, Smith KF, Kabb CP, Sebastian M, Moore GL, Schulze KD, Niemi S, Sawyer WG, Tran DD, Mitchell DA, Sumerlin BS, Flores CT, Angelini TE. Nat Commun. 2019 Jul 10;10(1):3029. doi: 10.1038/s41467-019-10919-1. PubMed |
| Acetylation of BMAL1 by TIP60 controls BRD4-P-TEFb recruitment to circadian promoters. Petkau N, Budak H, Zhou X, Oster H, Eichele G. Elife. 2019 Jul 11;8. pii: 43235. doi: 10.7554/eLife.43235. PubMed |
| The orphan nuclear receptor SHP regulates ER stress response by inhibiting XBP1s degradation. Sun S, Kelekar S, Kliewer SA, Mangelsdorf DJ. Genes Dev. 2019 Aug 1;33(15-16):1083-1094. doi: 10.1101/gad.326868.119. Epub 2019 Jul 11. PubMed |
Delivering Cas9/sgRNA ribonucleoprotein (RNP) by lentiviral capsid-based bionanoparticles for efficient 'hit-and-run' genome editing.
Lyu P, Javidi-Parsijani P, Atala A, Lu B.
Nucleic Acids Res. 2019 Jul 12. pii: 5531787. doi: 10.1093/nar/gkz605.
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| IKKalpha Kinase Regulates the DNA Damage Response and Drives Chemo-resistance in Cancer. Colomer C, Margalef P, Villanueva A, Vert A, Pecharroman I, Sole L, Gonzalez-Farre M, Alonso J, Montagut C, Martinez-Iniesta M, Bertran J, Borras E, Iglesias M, Sabido E, Bigas A, Boulton SJ, Espinosa L. Mol Cell. 2019 Aug 22;75(4):669-682.e5. doi: 10.1016/j.molcel.2019.05.036. Epub 2019 Jul 10. PubMed |
| Augmenting Immunotherapy Impact by Lowering Tumor TNF Cytotoxicity Threshold. Vredevoogd DW, Kuilman T, Ligtenberg MA, Boshuizen J, Stecker KE, de Bruijn B, Krijgsman O, Huang X, Kenski JCN, Lacroix R, Mezzadra R, Gomez-Eerland R, Yildiz M, Dagidir I, Apriamashvili G, Zandhuis N, van der Noort V, Visser NL, Blank CU, Altelaar M, Schumacher TN, Peeper DS. Cell. 2019 Jul 25;178(3):585-599.e15. doi: 10.1016/j.cell.2019.06.014. Epub 2019 Jul 11. PubMed |
Mechanisms of Progression of Myeloid Preleukemia to Transformed Myeloid Leukemia in Children with Down Syndrome.
Labuhn M, Perkins K, Matzk S, Varghese L, Garnett C, Papaemmanuil E, Metzner M, Kennedy A, Amstislavskiy V, Risch T, Bhayadia R, Samulowski D, Hernandez DC, Stoilova B, Iotchkova V, Oppermann U, Scheer C, Yoshida K, Schwarzer A, Taub JW, Crispino JD, Weiss MJ, Hayashi Y, Taga T, Ito E, Ogawa S, Reinhardt D, Yaspo ML, Campbell PJ, Roberts I, Constantinescu SN, Vyas P, Heckl D, Klusmann JH.
Cancer Cell. 2019 Aug 12;36(2):123-138.e10. doi: 10.1016/j.ccell.2019.06.007. Epub 2019 Jul 11.
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Engineering Forward Genetics into Cultured Cancer Cells for Chemical Target Identification.
Povedano JM, Liou J, Wei D, Srivatsav A, Kim J, Xie Y, Nijhawan D, McFadden DG.
Cell Chem Biol. 2019 Sep 19;26(9):1315-1321.e3. doi: 10.1016/j.chembiol.2019.06.006. Epub 2019 Jul 11.
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| Activation of the autophagy pathway by Torovirus infection is irrelevant for virus replication. Avila-Perez G, Diaz-Beneitez E, Cubas-Gaona LL, Nieves-Molina G, Rodriguez JR, Rodriguez JF, Rodriguez D. PLoS One. 2019 Jul 15;14(7):e0219428. doi: 10.1371/journal.pone.0219428. eCollection 2019. PubMed |
| SET Domain-Containing Protein 4 Epigenetically Controls Breast Cancer Stem Cell Quiescence. Ye S, Ding YF, Jia WH, Liu XL, Feng JY, Zhu Q, Cai SL, Yang YS, Lu QY, Huang XT, Yang JS, Jia SN, Ding GP, Wang YH, Zhou JJ, Chen YD, Yang WJ. Cancer Res. 2019 Sep 15;79(18):4729-4743. doi: 10.1158/0008-5472.CAN-19-1084. Epub 2019 Jul 15. PubMed |
| Membrane protein-regulated networks across human cancers. Lin CY, Lee CH, Chuang YH, Lee JY, Chiu YY, Wu Lee YH, Jong YJ, Hwang JK, Huang SH, Chen LC, Wu CH, Tu SH, Ho YS, Yang JM. Nat Commun. 2019 Jul 16;10(1):3131. doi: 10.1038/s41467-019-10920-8. PubMed |
Pooled library screening with multiplexed Cpf1 library.
Liu J, Srinivasan S, Li CY, Ho IL, Rose J, Shaheen M, Wang G, Yao W, Deem A, Bristow C, Hart T, Draetta G.
Nat Commun. 2019 Jul 17;10(1):3144. doi: 10.1038/s41467-019-10963-x.
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| Dynamic change of electrostatic field in TMEM16F permeation pathway shifts its ion selectivity. Ye W, Han TW, He M, Jan YN, Jan LY. Elife. 2019 Jul 18;8. pii: 45187. doi: 10.7554/eLife.45187. PubMed |
| The transporters SLC35A1 and SLC30A1 play opposite roles in cell survival upon VSV virus infection. Moskovskich A, Goldmann U, Kartnig F, Lindinger S, Konecka J, Fiume G, Girardi E, Superti-Furga G. Sci Rep. 2019 Jul 18;9(1):10471. doi: 10.1038/s41598-019-46952-9. PubMed |
| Loss of FGL1 induces epithelialmesenchymal transition and angiogenesis in LKB1 mutant lung adenocarcinoma. Bie F, Wang G, Qu X, Wang Y, Huang C, Wang Y, Du J. Int J Oncol. 2019 Sep;55(3):697-707. doi: 10.3892/ijo.2019.4838. Epub 2019 Jul 15. PubMed |
| CRISPR-Cas9 Mediated TSPO Gene Knockout alters Respiration and Cellular Metabolism in Human Primary Microglia Cells. Milenkovic VM, Slim D, Bader S, Koch V, Heinl ES, Alvarez-Carbonell D, Nothdurfter C, Rupprecht R, Wetzel CH. Int J Mol Sci. 2019 Jul 9;20(13). pii: ijms20133359. doi: 10.3390/ijms20133359. PubMed |
| A kinome-wide shRNA screen uncovers vaccinia-related kinase 3 (VRK3) as an essential gene for diffuse intrinsic pontine glioma survival. Silva-Evangelista C, Barret E, Menez V, Merlevede J, Kergrohen T, Saccasyn A, Oberlin E, Puget S, Beccaria K, Grill J, Castel D, Debily MA. Oncogene. 2019 Sep;38(38):6479-6490. doi: 10.1038/s41388-019-0884-5. Epub 2019 Jul 19. PubMed |
| PI31 Is an Adaptor Protein for Proteasome Transport in Axons and Required for Synaptic Development. Liu K, Jones S, Minis A, Rodriguez J, Molina H, Steller H. Dev Cell. 2019 Aug 19;50(4):509-524.e10. doi: 10.1016/j.devcel.2019.06.009. Epub 2019 Jul 18. PubMed |
| P11 Loss-of-Function is Associated with Decreased Cell Proliferation and Neurobehavioral Disorders in Mice. Liu G, Wang Y, Zheng W, Cheng H, Zhou R. Int J Biol Sci. 2019 May 20;15(7):1383-1395. doi: 10.7150/ijbs.33773. eCollection 2019. PubMed |
| Interferon-Inducible MicroRNA miR-128 Modulates HIV-1 Replication by Targeting TNPO3 mRNA. Bochnakian A, Zhen A, Zisoulis DG, Idica A, KewalRamani VN, Neel N, Daugaard I, Hamdorf M, Kitchen S, Lee K, Pedersen IM. J Virol. 2019 Sep 30;93(20). pii: JVI.00364-19. doi: 10.1128/JVI.00364-19. Print 2019 Oct 15. PubMed |
| Essential genes shape cancer genomes through linear limitation of homozygous deletions. Pertesi M, Ekdahl L, Palm A, Johnsson E, Jarvstrat L, Wihlborg AK, Nilsson B. Commun Biol. 2019 Jul 19;2:262. doi: 10.1038/s42003-019-0517-0. eCollection 2019. PubMed |
| PUMILIO, but not RBMX, binding is required for regulation of genomic stability by noncoding RNA NORAD. Elguindy MM, Kopp F, Goodarzi M, Rehfeld F, Thomas A, Chang TC, Mendell JT. Elife. 2019 Jul 25;8. pii: 48625. doi: 10.7554/eLife.48625. PubMed |
Towards a surrogate system to express human lipid binding TCRs.
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| Human Artificial Chromosomes that Bypass Centromeric DNA. Logsdon GA, Gambogi CW, Liskovykh MA, Barrey EJ, Larionov V, Miga KH, Heun P, Black BE. Cell. 2019 Jul 25;178(3):624-639.e19. doi: 10.1016/j.cell.2019.06.006. PubMed |
The AMPK-Related Kinases SIK1 and SIK3 Mediate Key Tumor-Suppressive Effects of LKB1 in NSCLC.
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| Stabilizing heterochromatin by DGCR8 alleviates senescence and osteoarthritis. Deng L, Ren R, Liu Z, Song M, Li J, Wu Z, Ren X, Fu L, Li W, Zhang W, Guillen P, Izpisua Belmonte JC, Chan P, Qu J, Liu GH. Nat Commun. 2019 Jul 26;10(1):3329. doi: 10.1038/s41467-019-10831-8. PubMed |
| Activation of PARP-1 by snoRNAs Controls Ribosome Biogenesis and Cell Growth via the RNA Helicase DDX21. Kim DS, Camacho CV, Nagari A, Malladi VS, Challa S, Kraus WL. Mol Cell. 2019 Sep 19;75(6):1270-1285.e14. doi: 10.1016/j.molcel.2019.06.020. Epub 2019 Jul 24. PubMed |
| Construction of a mavs-inactivated MDCK cell line for facilitating the propagation of canine distemper virus (CDV). Cai C, Wang X, Zhao Y, Yi C, Jin Z, Zhang A, Han L. Mol Immunol. 2019 Oct;114:133-138. doi: 10.1016/j.molimm.2019.06.013. Epub 2019 Jul 25. PubMed |
| Structural Basis for Target-Directed MicroRNA Degradation. Sheu-Gruttadauria J, Pawlica P, Klum SM, Wang S, Yario TA, Schirle Oakdale NT, Steitz JA, MacRae IJ. Mol Cell. 2019 Sep 19;75(6):1243-1255.e7. doi: 10.1016/j.molcel.2019.06.019. Epub 2019 Jul 25. PubMed |
| Bilirubin Links Heme Metabolism to Neuroprotection by Scavenging Superoxide. Vasavda C, Kothari R, Malla AP, Tokhunts R, Lin A, Ji M, Ricco C, Xu R, Saavedra HG, Sbodio JI, Snowman AM, Albacarys L, Hester L, Sedlak TW, Paul BD, Snyder SH. Cell Chem Biol. 2019 Oct 17;26(10):1450-1460.e7. doi: 10.1016/j.chembiol.2019.07.006. Epub 2019 Jul 25. PubMed |
| TREM1/3 Deficiency Impairs Tissue Repair After Acute Kidney Injury and Mitochondrial Metabolic Flexibility in Tubular Epithelial Cells. Tammaro A, Scantlebery AML, Rampanelli E, Borrelli C, Claessen N, Butter LM, Soriani A, Colonna M, Leemans JC, Dessing MC, Florquin S. Front Immunol. 2019 Jul 9;10:1469. doi: 10.3389/fimmu.2019.01469. eCollection 2019. PubMed |
| Regulatory mechanisms for the axonal localization of tau protein in neurons. Iwata M, Watanabe S, Yamane A, Miyasaka T, Misonou H. Mol Biol Cell. 2019 Sep 1;30(19):2441-2457. doi: 10.1091/mbc.E19-03-0183. Epub 2019 Aug 7. PubMed |
| ESCRT-mediated phagophore sealing during mitophagy. Zhen Y, Spangenberg H, Munson MJ, Brech A, Schink KO, Tan KW, Sorensen V, Wenzel EM, Radulovic M, Engedal N, Simonsen A, Raiborg C, Stenmark H. Autophagy. 2019 Aug 1:1-16. doi: 10.1080/15548627.2019.1639301. PubMed |
| Mapping cis-regulatory chromatin contacts in neural cells links neuropsychiatric disorder risk variants to target genes. Song M, Yang X, Ren X, Maliskova L, Li B, Jones IR, Wang C, Jacob F, Wu K, Traglia M, Tam TW, Jamieson K, Lu SY, Ming GL, Li Y, Yao J, Weiss LA, Dixon JR, Judge LM, Conklin BR, Song H, Gan L, Shen Y. Nat Genet. 2019 Aug;51(8):1252-1262. doi: 10.1038/s41588-019-0472-1. Epub 2019 Jul 31. PubMed |
| SALM1 controls synapse development by promoting F-actin/PIP2-dependent Neurexin clustering. Brouwer M, Farzana F, Koopmans F, Chen N, Brunner JW, Oldani S, Li KW, van Weering JR, Smit AB, Toonen RF, Verhage M. EMBO J. 2019 Sep 2;38(17):e101289. doi: 10.15252/embj.2018101289. Epub 2019 Aug 1. PubMed |
| Novel p97/VCP inhibitor induces endoplasmic reticulum stress and apoptosis in both bortezomib-sensitive and -resistant multiple myeloma cells. Nishimura N, Radwan MO, Amano M, Endo S, Fujii E, Hayashi H, Ueno S, Ueno N, Tatetsu H, Hata H, Okamoto Y, Otsuka M, Mitsuya H, Matsuoka M, Okuno Y. Cancer Sci. 2019 Oct;110(10):3275-3287. doi: 10.1111/cas.14154. Epub 2019 Aug 14. PubMed |
| A molecular triage process mediated by RING finger protein 126 and BCL2-associated athanogene 6 regulates degradation of G0/G1 switch gene 2. Kamikubo K, Kato H, Kioka H, Yamazaki S, Tsukamoto O, Nishida Y, Asano Y, Imamura H, Kawahara H, Shintani Y, Takashima S. J Biol Chem. 2019 Oct 4;294(40):14562-14573. doi: 10.1074/jbc.RA119.008544. Epub 2019 Aug 1. PubMed |
| Ifit1 regulates norovirus infection and enhances the interferon response in murine macrophage-like cells. Mears HV, Emmott E, Chaudhry Y, Hosmillo M, Goodfellow IG, Sweeney TR. Wellcome Open Res. 2019 May 15;4:82. doi: 10.12688/wellcomeopenres.15223.1. eCollection 2019. PubMed |
| Heterozygous Mutations in SMARCA2 Reprogram the Enhancer Landscape by Global Retargeting of SMARCA4. Gao F, Elliott NJ, Ho J, Sharp A, Shokhirev MN, Hargreaves DC. Mol Cell. 2019 Sep 5;75(5):891-904.e7. doi: 10.1016/j.molcel.2019.06.024. Epub 2019 Jul 30. PubMed |
| Innate Immune Response to Influenza Virus at Single-Cell Resolution in Human Epithelial Cells Revealed Paracrine Induction of Interferon Lambda 1. Ramos I, Smith G, Ruf-Zamojski F, Martinez-Romero C, Fribourg M, Carbajal EA, Hartmann BM, Nair VD, Marjanovic N, Monteagudo PL, DeJesus VA, Mutetwa T, Zamojski M, Tan GS, Jayaprakash C, Zaslavsky E, Albrecht RA, Sealfon SC, Garcia-Sastre A, Fernandez-Sesma A. J Virol. 2019 Sep 30;93(20). pii: JVI.00559-19. doi: 10.1128/JVI.00559-19. Print 2019 Oct 15. PubMed |
| Kaposi's Sarcoma-Associated Herpesvirus Lytic Replication Interferes with mTORC1 Regulation of Autophagy and Viral Protein Synthesis. Pringle ES, Robinson CA, McCormick C. J Virol. 2019 Oct 15;93(21). pii: JVI.00854-19. doi: 10.1128/JVI.00854-19. Print 2019 Nov 1. PubMed |
| CRISPR-based genomic loci labeling revealed ordered spatial organization of chromatin in living diploid human cells. Guo DG, Wang DB, Liu C, Lu S, Hou Y, Zhang XE. Biochim Biophys Acta Mol Cell Res. 2019 Dec;1866(12):118518. doi: 10.1016/j.bbamcr.2019.07.013. Epub 2019 Jul 31. PubMed |
| Coagulant activity of recombinant human factor VII produced by lentiviral human F7 gene transfer in immortalized hepatocyte-like cell line. Pongjantarasatian S, Kadegasem P, Sasanakul W, Sa-Ngiamsuntorn K, Borwornpinyo S, Sirachainan N, Chuansumrit A, Tanratana P, Hongeng S. PLoS One. 2019 Aug 5;14(8):e0220825. doi: 10.1371/journal.pone.0220825. eCollection 2019. PubMed |
| Elevated UCP1 levels are sufficient to improve glucose uptake in human white adipocytes. Tews D, Pula T, Funcke JB, Jastroch M, Keuper M, Debatin KM, Wabitsch M, Fischer-Posovszky P. Redox Biol. 2019 Sep;26:101286. doi: 10.1016/j.redox.2019.101286. Epub 2019 Jul 27. PubMed |
| The Kaposi's Sarcoma-Associated Herpesvirus Protein ORF42 Is Required for Efficient Virion Production and Expression of Viral Proteins. Butnaru M, Gaglia MM. Viruses. 2019 Aug 2;11(8). pii: v11080711. doi: 10.3390/v11080711. PubMed |
| 3D bioprinted endometrial stem cells on melt electrospun poly epsilon-caprolactone mesh for pelvic floor application promote anti-inflammatory responses in mice. Paul K, Darzi S, McPhee G, Del Borgo MP, Werkmeister JA, Gargett CE, Mukherjee S. Acta Biomater. 2019 Oct 1;97:162-176. doi: 10.1016/j.actbio.2019.08.003. Epub 2019 Aug 3. PubMed |
| SAMHD1 Regulates Human Papillomavirus 16-Induced Cell Proliferation and Viral Replication during Differentiation of Keratinocytes. James CD, Prabhakar AT, Otoa R, Evans MR, Wang X, Bristol ML, Zhang K, Li R, Morgan IM. mSphere. 2019 Aug 7;4(4). pii: 4/4/e00448-19. doi: 10.1128/mSphere.00448-19. PubMed |
| PORCN inhibition synergizes with PI3K/mTOR inhibition in Wnt-addicted cancers. Zhong Z, Sepramaniam S, Chew XH, Wood K, Lee MA, Madan B, Virshup DM. Oncogene. 2019 Oct;38(40):6662-6677. doi: 10.1038/s41388-019-0908-1. Epub 2019 Aug 7. PubMed |
| Hotspot SF3B1 mutations induce metabolic reprogramming and vulnerability to serine deprivation. Dalton WB, Helmenstine E, Walsh N, Gondek LP, Kelkar DS, Read A, Natrajan R, Christenson ES, Roman B, Das S, Zhao L, Leone RD, Shinn D, Groginski T, Madugundu AK, Patil A, Zabransky DJ, Medford A, Lee J, Cole AJ, Rosen M, Thakar M, Ambinder A, Donaldson J, DeZern AE, Cravero K, Chu D, Madero-Marroquin R, Pandey A, Hurley PJ, Lauring J, Park BH. J Clin Invest. 2019 Aug 8;130:4708-4723. doi: 10.1172/JCI125022. PubMed |
| Dephosphorylation activates the interferon-stimulated Schlafen family member 11 in the DNA damage response. Malone D, Lardelli RM, Li M, David M. J Biol Chem. 2019 Oct 4;294(40):14674-14685. doi: 10.1074/jbc.RA118.006588. Epub 2019 Aug 8. PubMed |
| Structural basis for AcrVA4 inhibition of specific CRISPR-Cas12a. Knott GJ, Cress BF, Liu JJ, Thornton BW, Lew RJ, Al-Shayeb B, Rosenberg DJ, Hammel M, Adler BA, Lobba MJ, Xu M, Arkin AP, Fellmann C, Doudna JA. Elife. 2019 Aug 9;8. pii: 49110. doi: 10.7554/eLife.49110. PubMed |
| USP49 potently stabilizes APOBEC3G protein by removing ubiquitin and inhibits HIV-1 replication. Pan T, Song Z, Wu L, Liu G, Ma X, Peng Z, Zhou M, Liang L, Liu B, Liu J, Zhang J, Zhang X, Huang R, Zhao J, Li Y, Ling X, Luo Y, Tang X, Cai W, Deng K, Li L, Zhang H. Elife. 2019 Aug 9;8. pii: 48318. doi: 10.7554/eLife.48318. PubMed |
| KH-Type Splicing Regulatory Protein Controls Colorectal Cancer Cell Growth and Modulates the Tumor Microenvironment. Caiazza F, Oficjalska K, Tosetto M, Phelan JJ, Noonan S, Martin P, Killick K, Breen L, O'Neill F, Nolan B, Furney S, Power R, Fennelly D, Craik CS, O'Sullivan J, Sheahan K, Doherty GA, Ryan EJ. Am J Pathol. 2019 Oct;189(10):1916-1932. doi: 10.1016/j.ajpath.2019.07.004. Epub 2019 Aug 9. PubMed |
| CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan. Vennin C, Melenec P, Rouet R, Nobis M, Cazet AS, Murphy KJ, Herrmann D, Reed DA, Lucas MC, Warren SC, Elgundi Z, Pinese M, Kalna G, Roden D, Samuel M, Zaratzian A, Grey ST, Da Silva A, Leung W, Mathivanan S, Wang Y, Braithwaite AW, Christ D, Benda A, Parkin A, Phillips PA, Whitelock JM, Gill AJ, Sansom OJ, Croucher DR, Parker BL, Pajic M, Morton JP, Cox TR, Timpson P. Nat Commun. 2019 Aug 12;10(1):3637. doi: 10.1038/s41467-019-10968-6. PubMed |
| The Hippo pathway modulates resistance to BET proteins inhibitors in lung cancer cells. Gobbi G, Donati B, Do Valle IF, Reggiani F, Torricelli F, Remondini D, Castellani G, Ambrosetti DC, Ciarrocchi A, Sancisi V. Oncogene. 2019 Oct;38(42):6801-6817. doi: 10.1038/s41388-019-0924-1. Epub 2019 Aug 12. PubMed |
| MRTF-A controls myofibroblastic differentiation of human multipotent stromal cells and their tumour-supporting function in xenograft models. Werner S, Lutzkendorf J, Muller T, Muller LP, Posern G. Sci Rep. 2019 Aug 13;9(1):11725. doi: 10.1038/s41598-019-48142-z. PubMed |
| MRP4 sustains Wnt/beta-catenin signaling for pregnancy, endometriosis and endometrial cancer. Chen JJ, Xiao ZJ, Meng X, Wang Y, Yu MK, Huang WQ, Sun X, Chen H, Duan YG, Jiang X, Wong MP, Chan HC, Zou F, Ruan YC. Theranostics. 2019 Jul 9;9(17):5049-5064. doi: 10.7150/thno.32097. eCollection 2019. PubMed |
| The long noncoding RNA CHROME regulates cholesterol homeostasis in primate. Hennessy EJ, van Solingen C, Scacalossi KR, Ouimet M, Afonso MS, Prins J, Koelwyn GJ, Sharma M, Ramkhelawon B, Carpenter S, Busch A, Chernogubova E, Matic LP, Hedin U, Maegdefessel L, Caffrey BE, Hussein MA, Ricci EP, Temel RE, Garabedian MJ, Berger JS, Vickers KC, Kanke M, Sethupathy P, Teupser D, Holdt LM, Moore KJ. Nat Metab. 2019 Jan;1(1):98-110. doi: 10.1038/s42255-018-0004-9. Epub 2018 Dec 3. PubMed |
| p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas. Hsieh MH, Choe JH, Gadhvi J, Kim YJ, Arguez MA, Palmer M, Gerold H, Nowak C, Do H, Mazambani S, Knighton JK, Cha M, Goodwin J, Kang MK, Jeong JY, Lee SY, Faubert B, Xuan Z, Abel ED, Scafoglio C, Shackelford DB, Minna JD, Singh PK, Shulaev V, Bleris L, Hoyt K, Kim J, Inoue M, DeBerardinis RJ, Kim TH, Kim JW. Cell Rep. 2019 Aug 13;28(7):1860-1878.e9. doi: 10.1016/j.celrep.2019.07.027. PubMed |
| A CEP104-CSPP1 Complex Is Required for Formation of Primary Cilia Competent in Hedgehog Signaling. Frikstad KM, Molinari E, Thoresen M, Ramsbottom SA, Hughes F, Letteboer SJF, Gilani S, Schink KO, Stokke T, Geimer S, Pedersen LB, Giles RH, Akhmanova A, Roepman R, Sayer JA, Patzke S. Cell Rep. 2019 Aug 13;28(7):1907-1922.e6. doi: 10.1016/j.celrep.2019.07.025. PubMed |
| A New MicroRNA Cluster Involved in the Reprogramming to a Pluripotent State. Sherstyuk VV, Davletshina GI, Vyatkin YV, Shtokalo DN, Vlasov VV, Zakian SM. Acta Naturae. 2019 Apr-Jun;11(2):92-97. doi: 10.32607/20758251-2019-11-2-92-97. PubMed |
| Epitranscriptomic Addition of m(5)C to HIV-1 Transcripts Regulates Viral Gene Expression. Courtney DG, Tsai K, Bogerd HP, Kennedy EM, Law BA, Emery A, Swanstrom R, Holley CL, Cullen BR. Cell Host Microbe. 2019 Aug 14;26(2):217-227.e6. doi: 10.1016/j.chom.2019.07.005. PubMed |
| TRPC6 Binds to and Activates Calpain, Independent of Its Channel Activity, and Regulates Podocyte Cytoskeleton, Cell Adhesion, and Motility. Farmer LK, Rollason R, Whitcomb DJ, Ni L, Goodliff A, Lay AC, Birnbaumer L, Heesom KJ, Xu SZ, Saleem MA, Welsh GI. J Am Soc Nephrol. 2019 Oct;30(10):1910-1924. doi: 10.1681/ASN.2018070729. Epub 2019 Aug 15. PubMed |
| The synthesis of branched-chain fatty acids is limited by enzymatic decarboxylation of ethyl- and methylmalonyl-CoA. Dewulf JP, Gerin I, Rider MH, Veiga-da-Cunha M, Van Schaftingen E, Bommer GT. Biochem J. 2019 Aug 30;476(16):2427-2447. doi: 10.1042/BCJ20190500. PubMed |
| CXCL14 suppresses human papillomavirus-associated head and neck cancer through antigen-specific CD8(+) T-cell responses by upregulating MHC-I expression. Westrich JA, Vermeer DW, Silva A, Bonney S, Berger JN, Cicchini L, Greer RO, Song JI, Raben D, Slansky JE, Lee JH, Spanos WC, Pyeon D. Oncogene. 2019 Nov;38(46):7166-7180. doi: 10.1038/s41388-019-0911-6. Epub 2019 Aug 15. PubMed |
| Cancer Cell-targeted and Activatable Photoimmunotherapy Spares T Cells in a 3D Coculture Model. Kercher EM, Nath S, Rizvi I, Spring BQ. Photochem Photobiol. 2019 Aug 19. doi: 10.1111/php.13153. PubMed |
| Systematic characterization of BAF mutations provides insights into intracomplex synthetic lethalities in human cancers. Schick S, Rendeiro AF, Runggatscher K, Ringler A, Boidol B, Hinkel M, Majek P, Vulliard L, Penz T, Parapatics K, Schmidl C, Menche J, Boehmelt G, Petronczki M, Muller AC, Bock C, Kubicek S. Nat Genet. 2019 Sep;51(9):1399-1410. doi: 10.1038/s41588-019-0477-9. Epub 2019 Aug 19. PubMed |
| Toll-like receptor mediated inflammation requires FASN-dependent MYD88 palmitoylation. Kim YC, Lee SE, Kim SK, Jang HD, Hwang I, Jin S, Hong EB, Jang KS, Kim HS. Nat Chem Biol. 2019 Sep;15(9):907-916. doi: 10.1038/s41589-019-0344-0. Epub 2019 Aug 19. PubMed |
| Essential thrombocytosis attributed to JAK2-T875N germline mutation. Yoshimitsu M, Hachiman M, Uchida Y, Arima N, Arai A, Kamada Y, Shide K, Ito M, Shimoda K, Ishitsuka K. Int J Hematol. 2019 Nov;110(5):584-590. doi: 10.1007/s12185-019-02725-8. Epub 2019 Aug 19. PubMed |
| Genomic Resolution of DLX-Orchestrated Transcriptional Circuits Driving Development of Forebrain GABAergic Neurons. Lindtner S, Catta-Preta R, Tian H, Su-Feher L, Price JD, Dickel DE, Greiner V, Silberberg SN, McKinsey GL, McManus MT, Pennacchio LA, Visel A, Nord AS, Rubenstein JLR. Cell Rep. 2019 Aug 20;28(8):2048-2063.e8. doi: 10.1016/j.celrep.2019.07.022. PubMed |
| Identification of an ATP-sensitive potassium channel in mitochondria. Paggio A, Checchetto V, Campo A, Menabo R, Di Marco G, Di Lisa F, Szabo I, Rizzuto R, De Stefani D. Nature. 2019 Aug;572(7771):609-613. doi: 10.1038/s41586-019-1498-3. Epub 2019 Aug 21. PubMed |
| Identifying chemogenetic interactions from CRISPR screens with drugZ. Colic M, Wang G, Zimmermann M, Mascall K, McLaughlin M, Bertolet L, Lenoir WF, Moffat J, Angers S, Durocher D, Hart T. Genome Med. 2019 Aug 22;11(1):52. doi: 10.1186/s13073-019-0665-3. PubMed |
| Plasticity of the Cullin-RING Ligase Repertoire Shapes Sensitivity to Ligand-Induced Protein Degradation. Mayor-Ruiz C, Jaeger MG, Bauer S, Brand M, Sin C, Hanzl A, Mueller AC, Menche J, Winter GE. Mol Cell. 2019 Aug 22;75(4):849-858.e8. doi: 10.1016/j.molcel.2019.07.013. PubMed |
| A Tag-Based Affinity Purification Mass Spectrometry Workflow for Systematic Isolation of the Human Mitochondrial Protein Complexes. Wu Z, Malty R, Moutaoufik MT, Zhang Q, Jessulat M, Babu M. Adv Exp Med Biol. 2019;1158:83-100. doi: 10.1007/978-981-13-8367-0_6. PubMed |
| Albumin evokes Ca(2+)-induced cell oxidative stress and apoptosis through TRPM2 channel in renal collecting duct cells reduced by curcumin. Naziroglu M, Cig B, Yazgan Y, Schwaerzer GK, Theilig F, Pecze L. Sci Rep. 2019 Aug 27;9(1):12403. doi: 10.1038/s41598-019-48716-x. PubMed |
| ZNNT1 long noncoding RNA induces autophagy to inhibit tumorigenesis of uveal melanoma by regulating key autophagy gene expression. Li P, He J, Yang Z, Ge S, Zhang H, Zhong Q, Fan X. Autophagy. 2019 Sep 3:1-14. doi: 10.1080/15548627.2019.1659614. PubMed |
| WNT5B governs the phenotype of basal-like breast cancer by activating WNT signaling. Jiang S, Zhang M, Zhang Y, Zhou W, Zhu T, Ruan Q, Chen H, Fang J, Zhou F, Sun J, Yang X. Cell Commun Signal. 2019 Aug 28;17(1):109. doi: 10.1186/s12964-019-0419-2. PubMed |
| Concomitant targeting of Hedgehog signaling and MCL-1 synergistically induces cell death in Hedgehog-driven cancer cells. Meister MT, Boedicker C, Linder B, Kogel D, Klingebiel T, Fulda S. Cancer Lett. 2019 Nov 28;465:1-11. doi: 10.1016/j.canlet.2019.08.012. Epub 2019 Aug 26. PubMed |
| Tanycytic TSPO inhibition induces lipophagy to regulate lipid metabolism and improve energy balance. Kim S, Kim N, Park S, Jeon Y, Lee J, Yoo SJ, Lee JW, Moon C, Yu SW, Kim EK. Autophagy. 2019 Aug 30:1-21. doi: 10.1080/15548627.2019.1659616. PubMed |
| Differential Activation of the Transcription Factor IRF1 Underlies the Distinct Immune Responses Elicited by Type I and Type III Interferons. Forero A, Ozarkar S, Li H, Lee CH, Hemann EA, Nadjsombati MS, Hendricks MR, So L, Green R, Roy CN, Sarkar SN, von Moltke J, Anderson SK, Gale M Jr, Savan R. Immunity. 2019 Sep 17;51(3):451-464.e6. doi: 10.1016/j.immuni.2019.07.007. Epub 2019 Aug 27. PubMed |
| Poly(ADP-Ribose) Polymerase 2 Recruits Replication Protein A to Sites of LINE-1 Integration to Facilitate Retrotransposition. Miyoshi T, Makino T, Moran JV. Mol Cell. 2019 Sep 19;75(6):1286-1298.e12. doi: 10.1016/j.molcel.2019.07.018. Epub 2019 Aug 28. PubMed |
| Sema3a-Nrp1 Signaling Mediates Fast-Twitch Myofiber Specificity of Tw2(+) Cells. Li S, Karri D, Sanchez-Ortiz E, Jaichander P, Bassel-Duby R, Liu N, Olson EN. Dev Cell. 2019 Oct 7;51(1):89-98.e4. doi: 10.1016/j.devcel.2019.08.002. Epub 2019 Aug 29. PubMed |
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| Circadian gene PER1 senses progesterone signal during human endometrial decidualization. Zhang Y, Meng N, Bao H, Jiang Y, Yang N, Wu K, Wu J, Wang H, Kong S, Zhang Y. J Endocrinol. 2019 Sep 1. pii: JOE-19-0284.R2. doi: 10.1530/JOE-19-0284. PubMed |
| Intraneuronal Tau Misfolding Induced by Extracellular Amyloid-beta Oligomers. Rudenko LK, Wallrabe H, Periasamy A, Siller KH, Svindrych Z, Seward ME, Best MN, Bloom GS. J Alzheimers Dis. 2019;71(4):1125-1138. doi: 10.3233/JAD-190226. PubMed |
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| Improved GaLV-TR Glycoproteins to Pseudotype Lentiviral Vectors: Impact of Viral Protease Activity in the Production of LV Pseudotypes. Tomas HA, Mestre DA, Rodrigues AF, Guerreiro MR, Carrondo MJT, Coroadinha AS. Mol Ther Methods Clin Dev. 2019 Aug 14;15:1-8. doi: 10.1016/j.omtm.2019.08.001. eCollection 2019 Dec 13. PubMed |
| MRI Tracking of SPIO- and Fth1-Labeled Bone Marrow Mesenchymal Stromal Cell Transplantation for Treatment of Stroke. Huang X, Xue Y, Wu J, Zhan Q, Zhao J. Contrast Media Mol Imaging. 2019 Aug 29;2019:5184105. doi: 10.1155/2019/5184105. eCollection 2019. PubMed |
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| Ran pathway-independent regulation of mitotic Golgi disassembly by Importin-alpha. Chang CC, Chen CJ, Grauffel C, Pien YC, Lim C, Tsai SY, Hsia KC. Nat Commun. 2019 Sep 20;10(1):4307. doi: 10.1038/s41467-019-12207-4. PubMed |
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| Mitochondrial Reprogramming Underlies Resistance to BCL-2 Inhibition in Lymphoid Malignancies. Guieze R, Liu VM, Rosebrock D, Jourdain AA, Hernandez-Sanchez M, Martinez Zurita A, Sun J, Ten Hacken E, Baranowski K, Thompson PA, Heo JM, Cartun Z, Aygun O, Iorgulescu JB, Zhang W, Notarangelo G, Livitz D, Li S, Davids MS, Biran A, Fernandes SM, Brown JR, Lako A, Ciantra ZB, Lawlor MA, Keskin DB, Udeshi ND, Wierda WG, Livak KJ, Letai AG, Neuberg D, Harper JW, Carr SA, Piccioni F, Ott CJ, Leshchiner I, Johannessen CM, Doench J, Mootha VK, Getz G, Wu CJ. Cancer Cell. 2019 Oct 14;36(4):369-384.e13. doi: 10.1016/j.ccell.2019.08.005. Epub 2019 Sep 19. PubMed |
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| Blockade of Glutathione Metabolism in IDH1-Mutated Glioma. Tang X, Fu X, Liu Y, Yu D, Cai SJ, Yang C. Mol Cancer Ther. 2020 Jan;19(1):221-230. doi: 10.1158/1535-7163.MCT-19-0103. Epub 2019 Sep 23. PubMed |
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ER-lysosome contacts enable cholesterol sensing by mTORC1 and drive aberrant growth signalling in Niemann-Pick type C.
Lim CY, Davis OB, Shin HR, Zhang J, Berdan CA, Jiang X, Counihan JL, Ory DS, Nomura DK, Zoncu R.
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| A genome-wide CRISPR screen identifies FBXO42 involvement in resistance toward MEK inhibition in NRAS-mutant melanoma. Nagler A, Vredevoogd DW, Alon M, Cheng PF, Trabish S, Kalaora S, Arafeh R, Goldin V, Levesque MP, Peeper DS, Samuels Y. Pigment Cell Melanoma Res. 2020 Mar;33(2):334-344. doi: 10.1111/pcmr.12825. Epub 2019 Oct 10. PubMed |
| Genome-Wide CRISPR-Cas9 Screen Reveals Selective Vulnerability of ATRX-Mutant Cancers to WEE1 Inhibition. Liang J, Zhao H, Diplas BH, Liu S, Liu J, Wang D, Lu Y, Zhu Q, Wu J, Wang W, Yan H, Zeng YX, Wang X, Jiao Y. Cancer Res. 2020 Feb 1;80(3):510-523. doi: 10.1158/0008-5472.CAN-18-3374. Epub 2019 Sep 24. PubMed |
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| Control over single-cell distribution of G1 lengths by WNT governs pluripotency. Jang J, Han D, Golkaram M, Audouard M, Liu G, Bridges D, Hellander S, Chialastri A, Dey SS, Petzold LR, Kosik KS. PLoS Biol. 2019 Sep 26;17(9):e3000453. doi: 10.1371/journal.pbio.3000453. eCollection 2019 Sep. PubMed |
| Protein phosphatase 2A controls ongoing DNA replication by binding to and regulating cell division cycle 45 (CDC45). Perl AL, O'Connor CM, Fa P, Mayca Pozo F, Zhang J, Zhang Y, Narla G. J Biol Chem. 2019 Nov 8;294(45):17043-17059. doi: 10.1074/jbc.RA119.010432. Epub 2019 Sep 27. PubMed |
| PRDM16 Maintains Homeostasis of the Intestinal Epithelium by Controlling Region-Specific Metabolism. Stine RR, Sakers AP, TeSlaa T, Kissig M, Stine ZE, Kwon CW, Cheng L, Lim HW, Kaestner KH, Rabinowitz JD, Seale P. Cell Stem Cell. 2019 Dec 5;25(6):830-845.e8. doi: 10.1016/j.stem.2019.08.017. Epub 2019 Sep 26. PubMed |
| Dynamic Incorporation of Histone H3 Variants into Chromatin Is Essential for Acquisition of Aggressive Traits and Metastatic Colonization. Gomes AP, Ilter D, Low V, Rosenzweig A, Shen ZJ, Schild T, Rivas MA, Er EE, McNally DR, Mutvei AP, Han J, Ou YH, Cavaliere P, Mullarky E, Nagiec M, Shin S, Yoon SO, Dephoure N, Massague J, Melnick AM, Cantley LC, Tyler JK, Blenis J. Cancer Cell. 2019 Oct 14;36(4):402-417.e13. doi: 10.1016/j.ccell.2019.08.006. Epub 2019 Sep 26. PubMed |
HIF-independent synthetic lethality between CDK4/6 inhibition and VHL loss across species.
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| Epigenetic Suppression of Interferon Lambda Receptor Expression Leads to Enhanced Human Norovirus Replication In Vitro. Arthur SE, Sorgeloos F, Hosmillo M, Goodfellow IG. mBio. 2019 Oct 1;10(5). pii: mBio.02155-19. doi: 10.1128/mBio.02155-19. PubMed |
| Liver-Type Glutaminase GLS2 Is a Druggable Metabolic Node in Luminal-Subtype Breast Cancer. Lukey MJ, Cluntun AA, Katt WP, Lin MJ, Druso JE, Ramachandran S, Erickson JW, Le HH, Wang ZE, Blank B, Greene KS, Cerione RA. Cell Rep. 2019 Oct 1;29(1):76-88.e7. doi: 10.1016/j.celrep.2019.08.076. PubMed |
| A PINCH-1-Smurf1 signaling axis mediates mechano-regulation of BMPR2 and stem cell differentiation. Guo L, Wang R, Zhang K, Yuan J, Wang J, Wang X, Ma J, Wu C. J Cell Biol. 2019 Nov 4;218(11):3773-3794. doi: 10.1083/jcb.201902022. Epub 2019 Oct 2. PubMed |
Conserved CxnC motifs in Kaposi's sarcoma-associated herpesvirus ORF66 are required for viral late gene expression and are essential for its interaction with ORF34.
Didychuk AL, Castaneda AF, Kushnir LO, Huang CJ, Glaunsinger BA.
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| Characterization of HIV-1 CRF01_AE env Genes Derived from Recently Infected Indonesian Individuals. Sasaki M, Kotaki T, Khairunisa SQ, Tachibana S, Ophinni Y, Hayashi Y, Nasronudin, Kameoka M. AIDS Res Hum Retroviruses. 2019 Oct 3. doi: 10.1089/aid.2019.0179. PubMed |
| SEMA4C is a novel target to limit osteosarcoma growth, progression, and metastasis. Smeester BA, Slipek NJ, Pomeroy EJ, Bomberger HE, Shamsan GA, Peterson JJ, Crosby MR, Draper GM, Becklin KL, Rahrmann EP, McCarthy JB, Odde DJ, Wood DK, Largaespada DA, Moriarity BS. Oncogene. 2020 Jan;39(5):1049-1062. doi: 10.1038/s41388-019-1041-x. Epub 2019 Oct 3. PubMed |
| Essential role of glucokinase in the protection of pancreatic beta cells to the glucose energetic status. Marques P, Kamitz A, Bartolome A, Burillo J, Martinez H, Jimenez B, Fernandez-Rhodes M, Guillen C, Benito M. Cell Death Discov. 2019 Sep 30;5:138. doi: 10.1038/s41420-019-0219-x. eCollection 2019. PubMed |
| Neuromodulator Signaling Bidirectionally Controls Vesicle Numbers in Human Synapses. Patzke C, Brockmann MM, Dai J, Gan KJ, Grauel MK, Fenske P, Liu Y, Acuna C, Rosenmund C, Sudhof TC. Cell. 2019 Oct 3;179(2):498-513.e22. doi: 10.1016/j.cell.2019.09.011. PubMed |
Genetic modification of primary human B cells to model high-grade lymphoma.
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Associated Plasmids |
| TIMP3 expression associates with prognosis in colorectal cancer and its novel arylsulfonamide inducer, MPT0B390, inhibits tumor growth, metastasis and angiogenesis. Huang HL, Liu YM, Sung TY, Huang TC, Cheng YW, Liou JP, Pan SL. Theranostics. 2019 Sep 18;9(22):6676-6689. doi: 10.7150/thno.34020. eCollection 2019. PubMed |
| Stimulation of Piezo1 by mechanical signals promotes bone anabolism. Li X, Han L, Nookaew I, Mannen E, Silva MJ, Almeida M, Xiong J. Elife. 2019 Oct 7;8. pii: 49631. doi: 10.7554/eLife.49631. PubMed |
| Live Cell Imaging to Assess the Dynamics of Metaphase Timing and Cell Fate Following Mitotic Spindle Perturbations. Mercadante DL, Crowley EA, Manning AL. J Vis Exp. 2019 Sep 20;(151). doi: 10.3791/60255. PubMed |
Pyrin dephosphorylation is sufficient to trigger inflammasome activation in familial Mediterranean fever patients.
Magnotti F, Lefeuvre L, Benezech S, Malsot T, Waeckel L, Martin A, Kerever S, Chirita D, Desjonqueres M, Duquesne A, Gerfaud-Valentin M, Laurent A, Seve P, Popoff MR, Walzer T, Belot A, Jamilloux Y, Henry T.
EMBO Mol Med. 2019 Oct 7:e10547. doi: 10.15252/emmm.201910547.
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Associated Plasmids |
| L-type voltage-gated Ca(2+) channel CaV1.2 regulates chondrogenesis during limb development. Atsuta Y, Tomizawa RR, Levin M, Tabin CJ. Proc Natl Acad Sci U S A. 2019 Oct 22;116(43):21592-21601. doi: 10.1073/pnas.1908981116. Epub 2019 Oct 7. PubMed |
Mechanosensing during directed cell migration requires dynamic actin polymerization at focal adhesions.
Puleo JI, Parker SS, Roman MR, Watson AW, Eliato KR, Peng L, Saboda K, Roe DJ, Ros R, Gertler FB, Mouneimne G.
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| Reduction of Global H3K27me(3) Enhances HER2/ErbB2 Targeted Therapy. Hirukawa A, Singh S, Wang J, Rennhack JP, Swiatnicki M, Sanguin-Gendreau V, Zuo D, Daldoul K, Lavoie C, Park M, Andrechek ER, Westbrook TF, Harris LN, Varadan V, Smith HW, Muller WJ. Cell Rep. 2019 Oct 8;29(2):249-257.e8. doi: 10.1016/j.celrep.2019.08.105. PubMed |
| Shank Proteins Couple the Endocytic Zone to the Postsynaptic Density to Control Trafficking and Signaling of Metabotropic Glutamate Receptor 5. Scheefhals N, Catsburg LAE, Westerveld ML, Blanpied TA, Hoogenraad CC, MacGillavry HD. Cell Rep. 2019 Oct 8;29(2):258-269.e8. doi: 10.1016/j.celrep.2019.08.102. PubMed |
| Chronic intermittent tachypacing by an optogenetic approach induces arrhythmia vulnerability in human engineered heart tissue. Lemme M, Braren I, Prondzynski M, Aksehirlioglu B, Ulmer BM, Schulze ML, Ismaili D, Meyer C, Hansen A, Christ T, Lemoine MD, Eschenhagen T. Cardiovasc Res. 2019 Oct 9. pii: 5584236. doi: 10.1093/cvr/cvz245. PubMed |
| Specific interactions of BCL-2 family proteins mediate sensitivity to BH3-mimetics in diffuse large B-cell lymphoma. Smith VM, Dietz A, Henz K, Bruecher D, Jackson R, Kowald L, van Wijk SJL, Jayne S, Macip S, Fulda S, Dyer MJS, Vogler M. Haematologica. 2019 Oct 10. pii: haematol.2019.220525. doi: 10.3324/haematol.2019.220525. PubMed |
| Therapeutic preferability of gemcitabine for ARID1A-deficient ovarian clear cell carcinoma. Kuroda T, Ogiwara H, Sasaki M, Takahashi K, Yoshida H, Kiyokawa T, Sudo K, Tamura K, Kato T, Okamoto A, Kohno T. Gynecol Oncol. 2019 Dec;155(3):489-498. doi: 10.1016/j.ygyno.2019.10.002. Epub 2019 Oct 8. PubMed |
| TFPa/HADHA is required for fatty acid beta-oxidation and cardiolipin re-modeling in human cardiomyocytes. Miklas JW, Clark E, Levy S, Detraux D, Leonard A, Beussman K, Showalter MR, Smith AT, Hofsteen P, Yang X, Macadangdang J, Manninen T, Raftery D, Madan A, Suomalainen A, Kim DH, Murry CE, Fiehn O, Sniadecki NJ, Wang Y, Ruohola-Baker H. Nat Commun. 2019 Oct 11;10(1):4671. doi: 10.1038/s41467-019-12482-1. PubMed |
| Profilin-Mediated Actin Allocation Regulates the Growth of Epithelial Microvilli. Faust JJ, Millis BA, Tyska MJ. Curr Biol. 2019 Oct 21;29(20):3457-3465.e3. doi: 10.1016/j.cub.2019.08.051. Epub 2019 Oct 10. PubMed |
| Individual cristae within the same mitochondrion display different membrane potentials and are functionally independent. Wolf DM, Segawa M, Kondadi AK, Anand R, Bailey ST, Reichert AS, van der Bliek AM, Shackelford DB, Liesa M, Shirihai OS. EMBO J. 2019 Nov 15;38(22):e101056. doi: 10.15252/embj.2018101056. Epub 2019 Oct 14. PubMed |
| Tumor-expressed B7-H3 mediates the inhibition of antitumor T-cell functions in ovarian cancer insensitive to PD-1 blockade therapy. Cai D, Li J, Liu D, Hong S, Qiao Q, Sun Q, Li P, Lyu N, Sun T, Xie S, Guo L, Ni L, Jin L, Dong C. Cell Mol Immunol. 2019 Oct 14. pii: 10.1038/s41423-019-0305-2. doi: 10.1038/s41423-019-0305-2. PubMed |
| Carboxypeptidase A6 Promotes the Proliferation and Migration of Hepatocellular Carcinoma by Up-regulating AKT Signaling Pathway. Huang QB, Zhang HW, Liao ZB. Curr Med Sci. 2019 Oct;39(5):727-733. doi: 10.1007/s11596-019-2098-z. Epub 2019 Oct 14. PubMed |
| Rare missense variants in the human cytosolic antibody receptor preserve antiviral function. Zeng J, Slodkowicz G, James LC. Elife. 2019 Oct 15;8. pii: 48339. doi: 10.7554/eLife.48339. PubMed |
| The ADP/ATP translocase drives mitophagy independent of nucleotide exchange. Hoshino A, Wang WJ, Wada S, McDermott-Roe C, Evans CS, Gosis B, Morley MP, Rathi KS, Li J, Li K, Yang S, McManus MJ, Bowman C, Potluri P, Levin M, Damrauer S, Wallace DC, Holzbaur ELF, Arany Z. Nature. 2019 Nov;575(7782):375-379. doi: 10.1038/s41586-019-1667-4. Epub 2019 Oct 16. PubMed |
| Inhibition of histone deacetylase 2 reduces MDM2 expression and reduces tumor growth in dedifferentiated liposarcoma. Seligson ND, Stets CW, Demoret BW, Awasthi A, Grosenbacher N, Shakya R, Hays JL, Chen JL. Oncotarget. 2019 Oct 1;10(55):5671-5679. doi: 10.18632/oncotarget.27144. eCollection 2019 Oct 1. PubMed |
| CircPLEKHM3 acts as a tumor suppressor through regulation of the miR-9/BRCA1/DNAJB6/KLF4/AKT1 axis in ovarian cancer. Zhang L, Zhou Q, Qiu Q, Hou L, Wu M, Li J, Li X, Lu B, Cheng X, Liu P, Lu W, Lu Y. Mol Cancer. 2019 Oct 17;18(1):144. doi: 10.1186/s12943-019-1080-5. PubMed |
| Direct RNA sequencing enables m(6)A detection in endogenous transcript isoforms at base-specific resolution. Lorenz DA, Sathe S, Einstein JM, Yeo GW. RNA. 2020 Jan;26(1):19-28. doi: 10.1261/rna.072785.119. Epub 2019 Oct 17. PubMed |
| The tumor suppressor TMEM127 regulates insulin sensitivity in a tissue-specific manner. Srikantan S, Deng Y, Cheng ZM, Luo A, Qin Y, Gao Q, Sande-Docor GM, Tao S, Zhang X, Harper N, Shannon CE, Fourcaudot M, Li Z, Kasinath BS, Harrison S, Ahuja S, Reddick RL, Dong LQ, Abdul-Ghani M, Norton L, Aguiar RCT, Dahia PLM. Nat Commun. 2019 Oct 17;10(1):4720. doi: 10.1038/s41467-019-12661-0. PubMed |
| Mammalian Surface Display Screening of Diverse Cystine-Dense Peptide Libraries for Difficult-to-Drug Targets. Crook ZR, Sevilla GP, Mhyre AJ, Olson JM. Methods Mol Biol. 2020;2070:363-396. doi: 10.1007/978-1-4939-9853-1_21. PubMed |
| MIGA2 Links Mitochondria, the ER, and Lipid Droplets and Promotes De Novo Lipogenesis in Adipocytes. Freyre CAC, Rauher PC, Ejsing CS, Klemm RW. Mol Cell. 2019 Dec 5;76(5):811-825.e14. doi: 10.1016/j.molcel.2019.09.011. Epub 2019 Oct 15. PubMed |
| MALT1 Phosphorylation Controls Activation of T Lymphocytes and Survival of ABC-DLBCL Tumor Cells. Gehring T, Erdmann T, Rahm M, Grass C, Flatley A, O'Neill TJ, Woods S, Meininger I, Karayel O, Kutzner K, Grau M, Shinohara H, Lammens K, Feederle R, Hauck SM, Lenz G, Krappmann D. Cell Rep. 2019 Oct 22;29(4):873-888.e10. doi: 10.1016/j.celrep.2019.09.040. PubMed |
| Exosome-Mediated MiR-155 Transfer Contributes to Hepatocellular Carcinoma Cell Proliferation by Targeting PTEN. Sun JF, Zhang D, Gao CJ, Zhang YW, Dai QS. Med Sci Monit Basic Res. 2019 Oct 24;25:218-228. doi: 10.12659/MSMBR.918134. PubMed |
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| Circular RNA circPICALM sponges miR-1265 to inhibit bladder cancer metastasis and influence FAK phosphorylation. Yan D, Dong W, He Q, Yang M, Huang L, Kong J, Qin H, Lin T, Huang J. EBioMedicine. 2019 Oct;48:316-331. doi: 10.1016/j.ebiom.2019.08.074. Epub 2019 Oct 21. PubMed |
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Godet I, Shin YJ, Ju JA, Ye IC, Wang G, Gilkes DM.
Nat Commun. 2019 Oct 24;10(1):4862. doi: 10.1038/s41467-019-12412-1.
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| Phase separation-deficient TDP43 Schmidt. Nat Commun. 2019 PubMed |
| Pyridoxamine-phosphate oxidases and pyridoxamine-phosphate oxidase-related proteins catalyze the oxidation of 6-NAD(P)H to NAD(P). Marbaix AY, Chehade G, Noel G, Morsomme P, Vertommen D, Bommer GT, Van Schaftingen E. Biochem J. 2019 Oct 30;476(20):3033-3052. doi: 10.1042/BCJ20190602. PubMed |
| Promoter demethylation of the asparagine synthetase gene is required for ATF4-dependent adaptation to asparagine depletion. Jiang J, Srivastava S, Seim G, Pavlova NN, King B, Zou L, Zhang C, Zhong M, Feng H, Kapur R, Wek RC, Fan J, Zhang J. J Biol Chem. 2019 Dec 6;294(49):18674-18684. doi: 10.1074/jbc.RA119.010447. Epub 2019 Oct 28. PubMed |
| Nucleus pulposus primary cilia alter their length in response to changes in extracellular osmolarity but do not control TonEBP-mediated osmoregulation. Choi H, Madhu V, Shapiro IM, Risbud MV. Sci Rep. 2019 Oct 29;9(1):15469. doi: 10.1038/s41598-019-51939-7. PubMed |
| Postmortem Cortex Samples Identify Distinct Molecular Subtypes of ALS: Retrotransposon Activation, Oxidative Stress, and Activated Glia. Tam OH, Rozhkov NV, Shaw R, Kim D, Hubbard I, Fennessey S, Propp N, Fagegaltier D, Harris BT, Ostrow LW, Phatnani H, Ravits J, Dubnau J, Gale Hammell M. Cell Rep. 2019 Oct 29;29(5):1164-1177.e5. doi: 10.1016/j.celrep.2019.09.066. PubMed |
| USP7-Dependent Regulation of TRAF Activation and Signaling by a Viral Interferon Regulatory Factor Homologue. Xiang Q, Ju H, Nicholas J. J Virol. 2020 Jan 6;94(2). pii: JVI.01553-19. doi: 10.1128/JVI.01553-19. Print 2020 Jan 6. PubMed |
| Environmental enrichment prevents Abeta oligomer-induced synaptic dysfunction through mirna-132 and hdac3 signaling pathways. Wei Z, Meng X, El Fatimy R, Sun B, Mai D, Zhang J, Arora R, Zeng A, Xu P, Qu S, Krichevsky AM, Selkoe DJ, Li S. Neurobiol Dis. 2020 Feb;134:104617. doi: 10.1016/j.nbd.2019.104617. Epub 2019 Oct 24. PubMed |
| A missense mutation in SNRPE linked to non-syndromal microcephaly interferes with U snRNP assembly and pre-mRNA splicing. Chen T, Zhang B, Ziegenhals T, Prusty AB, Frohler S, Grimm C, Hu Y, Schaefke B, Fang L, Zhang M, Kraemer N, Kaindl AM, Fischer U, Chen W. PLoS Genet. 2019 Oct 31;15(10):e1008460. doi: 10.1371/journal.pgen.1008460. eCollection 2019 Oct. PubMed |
| Modulation of Calretinin Expression in Human Mesothelioma Cells Reveals the Implication of the FAK and Wnt Signaling Pathways in Conferring Chemoresistance towards Cisplatin. Worthmuller J, Salicio V, Oberson A, Blum W, Schwaller B. Int J Mol Sci. 2019 Oct 29;20(21). pii: ijms20215391. doi: 10.3390/ijms20215391. PubMed |
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Peskova L, Cerna K, Oppelt J, Mraz M, Barta T.
Sci Rep. 2019 Oct 31;9(1):15759. doi: 10.1038/s41598-019-52294-3.
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| An anionic, endosome-escaping polymer to potentiate intracellular delivery of cationic peptides, biomacromolecules, and nanoparticles. Evans BC, Fletcher RB, Kilchrist KV, Dailing EA, Mukalel AJ, Colazo JM, Oliver M, Cheung-Flynn J, Brophy CM, Tierney JW, Isenberg JS, Hankenson KD, Ghimire K, Lander C, Gersbach CA, Duvall CL. Nat Commun. 2019 Nov 1;10(1):5012. doi: 10.1038/s41467-019-12906-y. PubMed |
| mTOR and autophagy pathways are dysregulated in murine and human models of Schaaf-Yang syndrome. Crutcher E, Pal R, Naini F, Zhang P, Laugsch M, Kim J, Bajic A, Schaaf CP. Sci Rep. 2019 Nov 4;9(1):15935. doi: 10.1038/s41598-019-52287-2. PubMed |
| Tumour exosomal CEMIP protein promotes cancer cell colonization in brain metastasis. Rodrigues G, Hoshino A, Kenific CM, Matei IR, Steiner L, Freitas D, Kim HS, Oxley PR, Scandariato I, Casanova-Salas I, Dai J, Badwe CR, Gril B, Tesic Mark M, Dill BD, Molina H, Zhang H, Benito-Martin A, Bojmar L, Ararso Y, Offer K, LaPlant Q, Buehring W, Wang H, Jiang X, Lu TM, Liu Y, Sabari JK, Shin SJ, Narula N, Ginter PS, Rajasekhar VK, Healey JH, Meylan E, Costa-Silva B, Wang SE, Rafii S, Altorki NK, Rudin CM, Jones DR, Steeg PS, Peinado H, Ghajar CM, Bromberg J, de Sousa M, Pisapia D, Lyden D. Nat Cell Biol. 2019 Nov;21(11):1403-1412. doi: 10.1038/s41556-019-0404-4. Epub 2019 Nov 4. PubMed |
| LCP1 triggers mTORC2/AKT activity and is pharmacologically targeted by enzastaurin in hypereosinophilia. Ma G, Gezer D, Herrmann O, Feldberg K, Schemionek M, Jawhar M, Reiter A, Brummendorf TH, Koschmieder S, Chatain N. Mol Carcinog. 2020 Jan;59(1):87-103. doi: 10.1002/mc.23131. Epub 2019 Nov 6. PubMed |
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Jia R, Bonifacino JS.
Elife. 2019 Nov 6;8. pii: 50034. doi: 10.7554/eLife.50034.
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| Aryl Sulfonamides Degrade RBM39 and RBM23 by Recruitment to CRL4-DCAF15. Ting TC, Goralski M, Klein K, Wang B, Kim J, Xie Y, Nijhawan D. Cell Rep. 2019 Nov 5;29(6):1499-1510.e6. doi: 10.1016/j.celrep.2019.09.079. PubMed |
| Epigenetic regulation of microglial phosphatidylinositol 3-kinase pathway involved in long-term potentiation and synaptic plasticity in rats. Saw G, Krishna K, Gupta N, Soong TW, Mallilankaraman K, Sajikumar S, Dheen ST. Glia. 2020 Mar;68(3):656-669. doi: 10.1002/glia.23748. Epub 2019 Nov 8. PubMed |
| Regulation of CHD2 expression by the Chaserr long noncoding RNA gene is essential for viability. Rom A, Melamed L, Gil N, Goldrich MJ, Kadir R, Golan M, Biton I, Perry RB, Ulitsky I. Nat Commun. 2019 Nov 8;10(1):5092. doi: 10.1038/s41467-019-13075-8. PubMed |
| Rab8 GTPase regulates Klotho-mediated inhibition of cell growth and progression by directly modulating its surface expression in human non-small cell lung cancer. Chen B, Huang S, Pisanic Ii TR, Stark A, Tao Y, Cheng B, Li Y, Wei Y, Zhao W, Wang TH, Wu J. EBioMedicine. 2019 Nov;49:118-132. doi: 10.1016/j.ebiom.2019.10.040. Epub 2019 Nov 6. PubMed |
| Production of Lentivirus for the Establishment of CAR-T Cells. Lana MG, Strauss BE. Methods Mol Biol. 2020;2086:61-67. doi: 10.1007/978-1-0716-0146-4_4. PubMed |
| Protein targeting chimeric molecules specific for dual bromodomain 4 (BRD4) and Polo-like kinase 1 (PLK1) proteins in acute myeloid leukemia cells. Mu X, Bai L, Xu Y, Wang J, Lu H. Biochem Biophys Res Commun. 2020 Jan 22;521(4):833-839. doi: 10.1016/j.bbrc.2019.11.007. Epub 2019 Nov 7. PubMed |
| Cell-Cycle Asynchrony Generates DNA Damage at Mitotic Entry in Polyploid Cells. Nano M, Gemble S, Simon A, Pennetier C, Fraisier V, Marthiens V, Basto R. Curr Biol. 2019 Nov 18;29(22):3937-3945.e7. doi: 10.1016/j.cub.2019.09.041. Epub 2019 Nov 7. PubMed |
| Collagen IV (COL4A1, COL4A2), a Component of the Viral Biofilm, Is Induced by the HTLV-1 Oncoprotein Tax and Impacts Virus Transmission. Millen S, Gross C, Donhauser N, Mann MC, Peloponese JM Jr, Thoma-Kress AK. Front Microbiol. 2019 Oct 23;10:2439. doi: 10.3389/fmicb.2019.02439. eCollection 2019. PubMed |
| JAK2 (V617F) -Mediated Clonal Hematopoiesis Accelerates Pathological Remodeling in Murine Heart Failure. Sano S, Wang Y, Yura Y, Sano M, Oshima K, Yang Y, Katanasaka Y, Min KD, Matsuura S, Ravid K, Mohi G, Walsh K. JACC Basic Transl Sci. 2019 Sep 18;4(6):684-697. doi: 10.1016/j.jacbts.2019.05.013. eCollection 2019 Oct. PubMed |
| Dose-dependent activation of gene expression is achieved using CRISPR and small molecules that recruit endogenous chromatin machinery. Chiarella AM, Butler KV, Gryder BE, Lu D, Wang TA, Yu X, Pomella S, Khan J, Jin J, Hathaway NA. Nat Biotechnol. 2020 Jan;38(1):50-55. doi: 10.1038/s41587-019-0296-7. Epub 2019 Nov 11. PubMed |
| Transplantation of neural scaffolds consisting of dermal fibroblast-reprogrammed neurons and 3D silk fibrous materials promotes the repair of spinal cord injury. Hu Y, Zhang F, Zhong W, Liu Y, He Q, Yang M, Chen H, Xu X, Bian K, Xu J, Li J, Shen Y, Zhang H. J Mater Chem B. 2019 Dec 21;7(47):7525-7539. doi: 10.1039/c9tb01929d. Epub 2019 Nov 13. PubMed |
| Fanconi-BRCA pathway mutations in childhood T-cell acute lymphoblastic leukemia. Pouliot GP, Degar J, Hinze L, Kochupurakkal B, Vo CD, Burns MA, Moreau L, Ganesa C, Roderick J, Peirs S, Menten B, Loh ML, Hunger SP, Silverman LB, Harris MH, Stevenson KE, Weinstock DM, Weng AP, Van Vlierberghe P, D'Andrea AD, Gutierrez A. PLoS One. 2019 Nov 13;14(11):e0221288. doi: 10.1371/journal.pone.0221288. eCollection 2019. PubMed |
| Lung Mammary Metastases but Not Primary Tumors Induce Accumulation of Atypical Large Platelets and Their Chemokine Expression. Zheng W, Zhang H, Zhao D, Zhang J, Pollard JW. Cell Rep. 2019 Nov 12;29(7):1747-1755.e4. doi: 10.1016/j.celrep.2019.10.016. PubMed |
| DUX4-Induced Histone Variants H3.X and H3.Y Mark DUX4 Target Genes for Expression. Resnick R, Wong CJ, Hamm DC, Bennett SR, Skene PJ, Hake SB, Henikoff S, van der Maarel SM, Tapscott SJ. Cell Rep. 2019 Nov 12;29(7):1812-1820.e5. doi: 10.1016/j.celrep.2019.10.025. PubMed |
| NIX-Mediated Mitophagy Promotes Effector Memory Formation in Antigen-Specific CD8(+) T Cells. Gupta SS, Sharp R, Hofferek C, Kuai L, Dorn GW 2nd, Wang J, Chen M. Cell Rep. 2019 Nov 12;29(7):1862-1877.e7. doi: 10.1016/j.celrep.2019.10.032. PubMed |
| Sox2 and Klf4 as the Functional Core in Pluripotency Induction without Exogenous Oct4. An Z, Liu P, Zheng J, Si C, Li T, Chen Y, Ma T, Zhang MQ, Zhou Q, Ding S. Cell Rep. 2019 Nov 12;29(7):1986-2000.e8. doi: 10.1016/j.celrep.2019.10.026. PubMed |
| eIF4A supports an oncogenic translation program in pancreatic ductal adenocarcinoma. Chan K, Robert F, Oertlin C, Kapeller-Libermann D, Avizonis D, Gutierrez J, Handly-Santana A, Doubrovin M, Park J, Schoepfer C, Da Silva B, Yao M, Gorton F, Shi J, Thomas CJ, Brown LE, Porco JA Jr, Pollak M, Larsson O, Pelletier J, Chio IIC. Nat Commun. 2019 Nov 13;10(1):5151. doi: 10.1038/s41467-019-13086-5. PubMed |
| Host signaling and EGR1 transcriptional control of human cytomegalovirus replication and latency. Buehler J, Carpenter E, Zeltzer S, Igarashi S, Rak M, Mikell I, Nelson JA, Goodrum F. PLoS Pathog. 2019 Nov 14;15(11):e1008037. doi: 10.1371/journal.ppat.1008037. eCollection 2019 Nov. PubMed |
| In vitro assay for the development of small molecule inhibitors targeting PD-1/PD-L1. Zhai W, Zhou X, Du J, Gao Y. Methods Enzymol. 2019;629:361-381. doi: 10.1016/bs.mie.2019.05.051. Epub 2019 Jun 17. PubMed |
| The KDM5A/RBP2 histone demethylase represses NOTCH signaling to sustain neuroendocrine differentiation and promote small cell lung cancer tumorigenesis. Oser MG, Sabet AH, Gao W, Chakraborty AA, Schinzel AC, Jennings RB, Fonseca R, Bonal DM, Booker MA, Flaifel A, Novak JS, Christensen CL, Zhang H, Herbert ZT, Tolstorukov MY, Buss EJ, Wong KK, Bronson RT, Nguyen QD, Signoretti S, Kaelin WG Jr. Genes Dev. 2019 Dec 1;33(23-24):1718-1738. doi: 10.1101/gad.328336.119. Epub 2019 Nov 14. PubMed |
| SERPINE2 promotes esophageal squamous cell carcinoma metastasis by activating BMP4. Zhang J, Luo A, Huang F, Gong T, Liu Z. Cancer Lett. 2020 Jan 28;469:390-398. doi: 10.1016/j.canlet.2019.11.011. Epub 2019 Nov 12. PubMed |
| Hemogenic Reprogramming of Human Fibroblasts by Enforced Expression of Transcription Factors. Silverio-Alves R, Gomes AM, Kurochkin I, Moore KA, Pereira CF. J Vis Exp. 2019 Nov 4;(153). doi: 10.3791/60112. PubMed |
| Metabolic interaction of hydrogen peroxide and hypoxia in zebrafish fibroblasts. Dikova V, Vorhauser J, Geng A, Pelster B, Sandbichler AM. Free Radic Biol Med. 2019 Nov 15. pii: S0891-5849(19)31527-8. doi: 10.1016/j.freeradbiomed.2019.11.015. PubMed |
| Delivery of nitric oxide with a nanocarrier promotes tumour vessel normalization and potentiates anti-cancer therapies. Sung YC, Jin PR, Chu LA, Hsu FF, Wang MR, Chang CC, Chiou SJ, Qiu JT, Gao DY, Lin CC, Chen YS, Hsu YC, Wang J, Wang FN, Yu PL, Chiang AS, Wu AY, Ko JJ, Lai CP, Lu TT, Chen Y. Nat Nanotechnol. 2019 Dec;14(12):1160-1169. doi: 10.1038/s41565-019-0570-3. Epub 2019 Nov 18. PubMed |
| EPS8 Facilitates Uncoating of Influenza A Virus. Larson GP, Tran V, Yu S, Cai Y, Higgins CA, Smith DM, Baker SF, Radoshitzky SR, Kuhn JH, Mehle A. Cell Rep. 2019 Nov 19;29(8):2175-2183.e4. doi: 10.1016/j.celrep.2019.10.064. PubMed |
| 3D Cellular Architecture Modulates Tyrosine Kinase Activity, Thereby Switching CD95-Mediated Apoptosis to Survival. Gulculer Balta GS, Monzel C, Kleber S, Beaudouin J, Balta E, Kaindl T, Chen S, Gao L, Thiemann M, Wirtz CR, Samstag Y, Tanaka M, Martin-Villalba A. Cell Rep. 2019 Nov 19;29(8):2295-2306.e6. doi: 10.1016/j.celrep.2019.10.054. PubMed |
| Suppressing Aneuploidy-Associated Phenotypes Improves the Fitness of Trisomy 21 Cells. Hwang S, Williams JF, Kneissig M, Lioudyno M, Rivera I, Helguera P, Busciglio J, Storchova Z, King MC, Torres EM. Cell Rep. 2019 Nov 19;29(8):2473-2488.e5. doi: 10.1016/j.celrep.2019.10.059. PubMed |
| Hepatitis Delta Virus Alters the Autophagy Process To Promote Its Genome Replication. Khabir M, Aliche AZ, Sureau C, Blanchet M, Labonte P. J Virol. 2020 Jan 31;94(4). pii: JVI.01936-19. doi: 10.1128/JVI.01936-19. Print 2020 Jan 31. PubMed |
| The ribosomal P-stalk couples amino acid starvation to GCN2 activation in mammalian cells. Harding HP, Ordonez A, Allen F, Parts L, Inglis AJ, Williams RL, Ron D. Elife. 2019 Nov 21;8. pii: 50149. doi: 10.7554/eLife.50149. PubMed |
| Optogenetic control of mesenchymal cell fate towards precise bone regeneration. Wang W, Huang D, Ren J, Li R, Feng Z, Guan C, Bao B, Cai B, Ling J, Zhou C. Theranostics. 2019 Oct 18;9(26):8196-8205. doi: 10.7150/thno.36455. eCollection 2019. PubMed |
| A retention-release mechanism based on RAB11FIP2 for AMPA receptor synaptic delivery during long-term potentiation. Royo M, Gutierrez Y, Fernandez-Monreal M, Gutierrez-Eisman S, Jimenez R, Jurado S, Esteban JA. J Cell Sci. 2019 Dec 16;132(24). pii: jcs.234237. doi: 10.1242/jcs.234237. PubMed |
| Functional Enhancers Shape Extrachromosomal Oncogene Amplifications. Morton AR, Dogan-Artun N, Faber ZJ, MacLeod G, Bartels CF, Piazza MS, Allan KC, Mack SC, Wang X, Gimple RC, Wu Q, Rubin BP, Shetty S, Angers S, Dirks PB, Sallari RC, Lupien M, Rich JN, Scacheri PC. Cell. 2019 Nov 27;179(6):1330-1341.e13. doi: 10.1016/j.cell.2019.10.039. Epub 2019 Nov 21. PubMed |
| Xenotransplanted Human Cortical Neurons Reveal Species-Specific Development and Functional Integration into Mouse Visual Circuits. Linaro D, Vermaercke B, Iwata R, Ramaswamy A, Libe-Philippot B, Boubakar L, Davis BA, Wierda K, Davie K, Poovathingal S, Penttila PA, Bilheu A, De Bruyne L, Gall D, Conzelmann KK, Bonin V, Vanderhaeghen P. Neuron. 2019 Dec 4;104(5):972-986.e6. doi: 10.1016/j.neuron.2019.10.002. Epub 2019 Nov 21. PubMed |
| BNC1 regulates cell heterogeneity in human pluripotent stem cell-derived epicardium. Gambardella L, McManus SA, Moignard V, Sebukhan D, Delaune A, Andrews S, Bernard WG, Morrison MA, Riley PR, Gottgens B, Gambardella Le Novere N, Sinha S. Development. 2019 Dec 13;146(24). pii: dev.174441. doi: 10.1242/dev.174441. PubMed |
| Entry by multiple picornaviruses is dependent on a pathway that includes TNK2, WASL, and NCK1. Jiang H, Leung C, Tahan S, Wang D. Elife. 2019 Nov 26;8. pii: 50276. doi: 10.7554/eLife.50276. PubMed |
| Reciprocal and Autonomous Glucocorticoid and Androgen Receptor Activation in Salivary Duct Carcinoma. Mitani Y, Lin SH, Pytynia KB, Ferrarotto R, El-Naggar AK. Clin Cancer Res. 2019 Nov 26. pii: 1078-0432.CCR-19-1603. doi: 10.1158/1078-0432.CCR-19-1603. PubMed |
| Sustained Secretion of the Antimicrobial Peptide S100A7 Is Dependent on the Downregulation of Caspase-8. Bhatt T, Bhosale A, Bajantri B, Mathapathi MS, Rizvi A, Scita G, Majumdar A, Jamora C. Cell Rep. 2019 Nov 26;29(9):2546-2555.e4. doi: 10.1016/j.celrep.2019.10.090. PubMed |
| Global Analysis of Enhancer Targets Reveals Convergent Enhancer-Driven Regulatory Modules. Xie S, Armendariz D, Zhou P, Duan J, Hon GC. Cell Rep. 2019 Nov 26;29(9):2570-2578.e5. doi: 10.1016/j.celrep.2019.10.073. PubMed |
| The targetable kinase PIM1 drives ALK inhibitor resistance in high-risk neuroblastoma independent of MYCN status. Trigg RM, Lee LC, Prokoph N, Jahangiri L, Reynolds CP, Amos Burke GA, Probst NA, Han M, Matthews JD, Lim HK, Manners E, Martinez S, Pastor J, Blanco-Aparicio C, Merkel O, de Los Fayos Alonso IG, Kodajova P, Tangermann S, Hogler S, Luo J, Kenner L, Turner SD. Nat Commun. 2019 Nov 28;10(1):5428. doi: 10.1038/s41467-019-13315-x. PubMed |
| Evaluation of reference genes for quantitative real-time PCR in Wharton's Jelly-derived mesenchymal stem cells after lentiviral transduction and differentiation. Borkowska P, Zielinska A, Paul-Samojedny M, Stojko R, Kowalski J. Mol Biol Rep. 2020 Feb;47(2):1107-1115. doi: 10.1007/s11033-019-05207-6. Epub 2019 Nov 28. PubMed |
CRISPR-Switch regulates sgRNA activity by Cre recombination for sequential editing of two loci.
Chylinski K, Hubmann M, Hanna RE, Yanchus C, Michlits G, Uijttewaal ECH, Doench J, Schramek D, Elling U.
Nat Commun. 2019 Nov 29;10(1):5454. doi: 10.1038/s41467-019-13403-y.
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| KSHV activates unfolded protein response sensors but suppresses downstream transcriptional responses to support lytic replication. Johnston BP, Pringle ES, McCormick C. PLoS Pathog. 2019 Dec 2;15(12):e1008185. doi: 10.1371/journal.ppat.1008185. eCollection 2019 Dec. PubMed |
| ADAP1 promotes invasive squamous cell carcinoma progression and predicts patient survival. Van Duzer A, Taniguchi S, Elhance A, Tsujikawa T, Oshimori N. Life Sci Alliance. 2019 Dec 2;2(6). pii: 2/6/e201900582. doi: 10.26508/lsa.201900582. Print 2019 Dec. PubMed |
| A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity. Khan S, Zhang X, Lv D, Zhang Q, He Y, Zhang P, Liu X, Thummuri D, Yuan Y, Wiegand JS, Pei J, Zhang W, Sharma A, McCurdy CR, Kuruvilla VM, Baran N, Ferrando AA, Kim YM, Rogojina A, Houghton PJ, Huang G, Hromas R, Konopleva M, Zheng G, Zhou D. Nat Med. 2019 Dec;25(12):1938-1947. doi: 10.1038/s41591-019-0668-z. Epub 2019 Dec 2. PubMed |
| Mechanisms of nuclear content loading to exosomes. Yokoi A, Villar-Prados A, Oliphint PA, Zhang J, Song X, De Hoff P, Morey R, Liu J, Roszik J, Clise-Dwyer K, Burks JK, O'Halloran TJ, Laurent LC, Sood AK. Sci Adv. 2019 Nov 20;5(11):eaax8849. doi: 10.1126/sciadv.aax8849. eCollection 2019 Nov. PubMed |
| Suppression of Ribosomal Pausing by eIF5A Is Necessary to Maintain the Fidelity of Start Codon Selection. Manjunath H, Zhang H, Rehfeld F, Han J, Chang TC, Mendell JT. Cell Rep. 2019 Dec 3;29(10):3134-3146.e6. doi: 10.1016/j.celrep.2019.10.129. PubMed |
| Exploring the potential of BH3 mimetic therapy in squamous cell carcinoma of the head and neck. Carter RJ, Milani M, Butterworth M, Alotibi A, Harper N, Yedida G, Greaves G, Al-Zebeeby A, Jorgensen AL, Schache AG, Risk JM, Shaw RJ, Jones TM, Sacco JJ, Hurlstone A, Cohen GM, Varadarajan S. Cell Death Dis. 2019 Dec 4;10(12):912. doi: 10.1038/s41419-019-2150-8. PubMed |
| Reactive oxygen/nitrogen species contribute substantially to the antileukemia effect of APO866, a NAD lowering agent. Cloux AJ, Aubry D, Heulot M, Widmann C, ElMokh O, Piacente F, Cea M, Nencioni A, Bellotti A, Bouzourene K, Pellegrin M, Mazzolai L, Duchosal MA, Nahimana A. Oncotarget. 2019 Nov 19;10(62):6723-6738. doi: 10.18632/oncotarget.27336. eCollection 2019 Nov 19. PubMed |
| IL-36gamma drives skin toxicity induced by EGFR/MEK inhibition and commensal Cutibacterium acnes. Satoh TK, Mellett M, Meier-Schiesser B, Fenini G, Otsuka A, Beer HD, Rordorf T, Maul JT, Hafner J, Navarini AA, Contassot E, French LE. J Clin Invest. 2020 Feb 4. pii: 128678. doi: 10.1172/JCI128678. PubMed |
| Deregulation of the Histone Lysine-Specific Demethylase 1 Is Involved in Human Hepatocellular Carcinoma. Kim S, Bolatkan A, Kaneko S, Ikawa N, Asada K, Komatsu M, Hayami S, Ojima H, Abe N, Yamaue H, Hamamoto R. Biomolecules. 2019 Dec 1;9(12). pii: biom9120810. doi: 10.3390/biom9120810. PubMed |
| Nanoscale coupling of endocytic pit growth and stability. Lehmann M, Lukonin I, Noe F, Schmoranzer J, Clementi C, Loerke D, Haucke V. Sci Adv. 2019 Nov 27;5(11):eaax5775. doi: 10.1126/sciadv.aax5775. eCollection 2019 Nov. PubMed |
| CSB promoter downregulation via histone H3 hypoacetylation is an early determinant of replicative senescence. Crochemore C, Fernandez-Molina C, Montagne B, Salles A, Ricchetti M. Nat Commun. 2019 Dec 6;10(1):5576. doi: 10.1038/s41467-019-13314-y. PubMed |
| A generic cell surface ligand system for studying cell-cell recognition. Denham EM, Barton MI, Black SM, Bridge MJ, de Wet B, Paterson RL, van der Merwe PA, Goyette J. PLoS Biol. 2019 Dec 9;17(12):e3000549. doi: 10.1371/journal.pbio.3000549. eCollection 2019 Dec. PubMed |
| Vitamin D promotes the cisplatin sensitivity of oral squamous cell carcinoma by inhibiting LCN2-modulated NF-kappaB pathway activation through RPS3. Huang Z, Zhang Y, Li H, Zhou Y, Zhang Q, Chen R, Jin T, Hu K, Li S, Wang Y, Chen W, Huang Z. Cell Death Dis. 2019 Dec 9;10(12):936. doi: 10.1038/s41419-019-2177-x. PubMed |
| Expression of AXL receptor tyrosine kinase relates to monocyte dysfunction and severity of cirrhosis. Brenig R, Pop OT, Triantafyllou E, Geng A, Singanayagam A, Perez-Shibayama C, Besse L, Cupovic J, Kunzler P, Boldanova T, Brand S, Semela D, Duong FH, Weston CJ, Ludewig B, Heim MH, Wendon J, Antoniades CG, Bernsmeier C. Life Sci Alliance. 2019 Dec 10;3(1). pii: 3/1/e201900465. doi: 10.26508/lsa.201900465. Print 2020 Jan. PubMed |
| Nucleic acid-targeted pathogen reduction technique in red blood cells by UV-generated oxygen radicals for optimising recipient safety. Zhang Q, Wu C, Fan Y, Xu T, Meng Q, Wang S, Liu Q, Yao C, Jiang T. Transfus Med. 2019 Dec 10. doi: 10.1111/tme.12654. PubMed |
| Regulated resurfacing of a somatostatin receptor storage compartment fine-tunes pituitary secretion. Alshafie W, Francis V, Bednarz K, Pan YE, Stroh T, McPherson PS. J Cell Biol. 2020 Jan 6;219(1). pii: 132745. doi: 10.1083/jcb.201904054. PubMed |
| Endogenous IGF Signaling Directs Heterogeneous Mesoderm Differentiation in Human Embryonic Stem Cells. Yang Y, Ren Z, Xu F, Meng Y, Zhang Y, Ai N, Long Y, Fok HI, Deng C, Zhao X, Huang L, Zhao Q, Wang J, Liu W, Ge W, Chen G. Cell Rep. 2019 Dec 10;29(11):3374-3384.e5. doi: 10.1016/j.celrep.2019.11.047. PubMed |
| Post-translational Modification of OTULIN Regulates Ubiquitin Dynamics and Cell Death. Douglas T, Saleh M. Cell Rep. 2019 Dec 10;29(11):3652-3663.e5. doi: 10.1016/j.celrep.2019.11.014. PubMed |
| A primate-specific retroviral enhancer wires the XACT lncRNA into the core pluripotency network in humans. Casanova M, Moscatelli M, Chauviere LE, Huret C, Samson J, Liyakat Ali TM, Rosspopoff O, Rougeulle C. Nat Commun. 2019 Dec 11;10(1):5652. doi: 10.1038/s41467-019-13551-1. PubMed |
| NOTCH1 signaling in oral squamous cell carcinoma via a TEL2/SERPINE1 axis. Salameti V, Bhosale PG, Ames-Draycott A, Sipila K, Watt FM. Oncotarget. 2019 Nov 26;10(63):6791-6804. doi: 10.18632/oncotarget.27306. eCollection 2019 Nov 26. PubMed |
| Significant Role of Dicer and miR-223 in Adipose Tissue of Polycystic Ovary Syndrome Patients. Qin L, Chen J, Tang L, Zuo T, Chen H, Gao R, Xu W. Biomed Res Int. 2019 Nov 11;2019:9193236. doi: 10.1155/2019/9193236. eCollection 2019. PubMed |
| ARID1A prevents squamous cell carcinoma initiation and chemoresistance by antagonizing pRb/E2F1/c-Myc-mediated cancer stemness. Luo Q, Wu X, Chang W, Zhao P, Nan Y, Zhu X, Katz JP, Su D, Liu Z. Cell Death Differ. 2019 Dec 12. pii: 10.1038/s41418-019-0475-6. doi: 10.1038/s41418-019-0475-6. PubMed |
| Telophase correction refines division orientation in stratified epithelia. Lough KJ, Byrd KM, Descovich CP, Spitzer DC, Bergman AJ, Beaudoin GM 3rd, Reichardt LF, Williams SE. Elife. 2019 Dec 13;8. pii: 49249. doi: 10.7554/eLife.49249. PubMed |
| Inhibition of Osteoclastogenesis by the RNA-Binding Protein QKI5: a Novel Approach to Protect from Bone Resorption. Rauwel B, Degboe Y, Diallo K, Sayegh S, Baron M, Boyer JF, Constantin A, Cantagrel A, Davignon JL. J Bone Miner Res. 2019 Dec 13. doi: 10.1002/jbmr.3943. PubMed |
| Proteolytic Processing of Neuregulin 2. Czarnek M, Bereta J. Mol Neurobiol. 2019 Dec 14. pii: 10.1007/s12035-019-01846-9. doi: 10.1007/s12035-019-01846-9. PubMed |
| RCC2 promotes breast cancer progression through regulation of Wnt signaling and inducing EMT. Chen Z, Wu W, Huang Y, Xie L, Li Y, Chen H, Li W, Yin D, Hu K. J Cancer. 2019 Nov 1;10(27):6837-6847. doi: 10.7150/jca.36430. eCollection 2019. PubMed |
| Modulation of N-Methyl-N-nitrosourea Mutagenesis in Mouse Embryo Fibroblasts Derived from the gpt Delta Mouse by an Inhibitor of the O(6)-Methylguanine Methyltransferase, MGMT. Thongararm P, Fedeles BI, Khumsubdee S, Armijo AL, Kim L, Thiantanawat A, Promvijit J, Navasumrit P, Ruchirawat M, Croy RG, Essigmann JM. Chem Res Toxicol. 2020 Feb 17;33(2):625-633. doi: 10.1021/acs.chemrestox.9b00444. Epub 2019 Dec 24. PubMed |
| APOBEC3A is a prominent cytidine deaminase in breast cancer. Cortez LM, Brown AL, Dennis MA, Collins CD, Brown AJ, Mitchell D, Mertz TM, Roberts SA. PLoS Genet. 2019 Dec 16;15(12):e1008545. doi: 10.1371/journal.pgen.1008545. eCollection 2019 Dec. PubMed |
| Ly49R activation receptor drives self-MHC-educated NK cell immunity against cytomegalovirus infection. Gamache A, Cronk JM, Nash WT, Puchalski P, Gillespie A, Wei H, Gray L, Hammarskjold ML, Xu W, Brown MG. Proc Natl Acad Sci U S A. 2019 Dec 16. pii: 1913064117. doi: 10.1073/pnas.1913064117. PubMed |
| Inhibition of ULK1 and Beclin1 by an alpha-herpesvirus Akt-like Ser/Thr kinase limits autophagy to stimulate virus replication. Rubio RM, Mohr I. Proc Natl Acad Sci U S A. 2019 Dec 16. pii: 1915139116. doi: 10.1073/pnas.1915139116. PubMed |
| TULIP2: An Improved Method for the Identification of Ubiquitin E3-Specific Targets. Salas-Lloret D, Agabitini G, Gonzalez-Prieto R. Front Chem. 2019 Nov 26;7:802. doi: 10.3389/fchem.2019.00802. eCollection 2019. PubMed |
| Cellular IP6 Levels Limit HIV Production while Viruses that Cannot Efficiently Package IP6 Are Attenuated for Infection and Replication. Mallery DL, Faysal KMR, Kleinpeter A, Wilson MSC, Vaysburd M, Fletcher AJ, Novikova M, Bocking T, Freed EO, Saiardi A, James LC. Cell Rep. 2019 Dec 17;29(12):3983-3996.e4. doi: 10.1016/j.celrep.2019.11.050. PubMed |
| LC3C-Mediated Autophagy Selectively Regulates the Met RTK and HGF-Stimulated Migration and Invasion. Bell ES, Coelho PP, Ratcliffe CDH, Rajadurai CV, Peschard P, Vaillancourt R, Zuo D, Park M. Cell Rep. 2019 Dec 17;29(12):4053-4068.e6. doi: 10.1016/j.celrep.2019.11.063. PubMed |
| Spatial Genome Re-organization between Fetal and Adult Hematopoietic Stem Cells. Chen C, Yu W, Tober J, Gao P, He B, Lee K, Trieu T, Blobel GA, Speck NA, Tan K. Cell Rep. 2019 Dec 17;29(12):4200-4211.e7. doi: 10.1016/j.celrep.2019.11.065. PubMed |
| The phytohormone forchlorfenuron decreases viability and proliferation of malignant mesothelioma cells in vitro and in vivo. Blum W, Henzi T, Pecze L, Diep KL, Bochet CG, Schwaller B. Oncotarget. 2019 Dec 10;10(65):6944-6956. doi: 10.18632/oncotarget.27341. eCollection 2019 Dec 10. PubMed |
Molecular Tuning of the Axonal Mitochondrial Ca(2+) Uniporter Ensures Metabolic Flexibility of Neurotransmission.
Ashrafi G, de Juan-Sanz J, Farrell RJ, Ryan TA.
Neuron. 2019 Dec 10. pii: S0896-6273(19)30984-5. doi: 10.1016/j.neuron.2019.11.020.
PubMed
Associated Plasmids |
| The SINEB1 element in the long non-coding RNA Malat1 is necessary for TDP-43 proteostasis. Nguyen TM, Kabotyanski EB, Reineke LC, Shao J, Xiong F, Lee JH, Dubrulle J, Johnson H, Stossi F, Tsoi PS, Choi KJ, Ellis AG, Zhao N, Cao J, Adewunmi O, Ferreon JC, Ferreon ACM, Neilson JR, Mancini MA, Chen X, Kim J, Ma L, Li W, Rosen JM. Nucleic Acids Res. 2020 Mar 18;48(5):2621-2642. doi: 10.1093/nar/gkz1176. PubMed |
| Low-Level Saturated Fatty Acid Palmitate Benefits Liver Cells by Boosting Mitochondrial Metabolism via CDK1-SIRT3-CPT2 Cascade. Liu L, Xie B, Fan M, Candas-Green D, Jiang JX, Wei R, Wang Y, Chen HW, Hu Y, Li JJ. Dev Cell. 2020 Jan 27;52(2):196-209.e9. doi: 10.1016/j.devcel.2019.11.012. Epub 2019 Dec 19. PubMed |
| The stem cell-specific long noncoding RNA HOXA10-AS in the pathogenesis of KMT2A-rearranged leukemia. Al-Kershi S, Bhayadia R, Ng M, Verboon L, Emmrich S, Gack L, Schwarzer A, Strowig T, Heckl D, Klusmann JH. Blood Adv. 2019 Dec 23;3(24):4252-4263. doi: 10.1182/bloodadvances.2019032029. PubMed |
| CRISPR-mediated modeling and functional validation of candidate tumor suppressor genes in small cell lung cancer. Ng SR, Rideout WM 3rd, Akama-Garren EH, Bhutkar A, Mercer KL, Schenkel JM, Bronson RT, Jacks T. Proc Natl Acad Sci U S A. 2020 Jan 7;117(1):513-521. doi: 10.1073/pnas.1821893117. Epub 2019 Dec 23. PubMed |
Subcellular drug targeting illuminates local kinase action.
Bucko PJ, Lombard CK, Rathbun L, Garcia I, Bhat A, Wordeman L, Smith FD, Maly DJ, Hehnly H, Scott JD.
Elife. 2019 Dec 24;8. pii: 52220. doi: 10.7554/eLife.52220.
PubMed
Associated Plasmids |
| Sideroflexin 4 affects Fe-S cluster biogenesis, iron metabolism, mitochondrial respiration and heme biosynthetic enzymes. Paul BT, Tesfay L, Winkler CR, Torti FM, Torti SV. Sci Rep. 2019 Dec 23;9(1):19634. doi: 10.1038/s41598-019-55907-z. PubMed |
| WBP11 is required for splicing the TUBGCP6 pre-mRNA to promote centriole duplication. Park EM, Scott PM, Clutario K, Cassidy KB, Zhan K, Gerber SA, Holland AJ. J Cell Biol. 2020 Jan 6;219(1). pii: 133543. doi: 10.1083/jcb.201904203. PubMed |
| Construction of an Inducible CRISPR/Cas9 System for CXCR4 Gene and Demonstration of its Effects on MKN-45 Cells. Peng Y, Yang T, Tang X, Chen F, Wang S. Cell Biochem Biophys. 2019 Dec 24. pii: 10.1007/s12013-019-00898-x. doi: 10.1007/s12013-019-00898-x. PubMed |
| Molecular Basis for Autosomal-Dominant Renal Fanconi Syndrome Caused by HNF4A. Marchesin V, Perez-Marti A, Le Meur G, Pichler R, Grand K, Klootwijk ED, Kesselheim A, Kleta R, Lienkamp S, Simons M. Cell Rep. 2019 Dec 24;29(13):4407-4421.e5. doi: 10.1016/j.celrep.2019.11.066. PubMed |
| Silencing of Long Non-coding RNA RP1-93H18.6 Acts as a Tumor Suppressor in Cervical Cancer through the Blockade of the PI3K/Akt Axis. Wang Q, Yan SP, Chu DX, Xie Y, Wang CF, Zhang JY, Li WC, Guo RX. Mol Ther Nucleic Acids. 2019 Nov 15;19:304-317. doi: 10.1016/j.omtn.2019.10.041. PubMed |
| Enterovirus 71 Represses Interleukin Enhancer-Binding Factor 2 Production and Nucleus Translocation to Antagonize ILF2 Antiviral Effects. Jin J, Wang W, Ai S, Liu W, Song Y, Luo Z, Zhang Q, Wu K, Liu Y, Wu J. Viruses. 2019 Dec 23;12(1). pii: v12010022. doi: 10.3390/v12010022. PubMed |
| Functional Dissection of Mitosis Using Immortalized Fibroblasts from the Indian Muntjac, a Placental Mammal with Only Three Chromosomes. Almeida AC, Drpic D, Okada N, Bravo J, Madureira M, Maiato H. Methods Mol Biol. 2020;2101:247-266. doi: 10.1007/978-1-0716-0219-5_16. PubMed |
| Signalling lymphocyte activation molecule family member 9 is found on select subsets of antigen-presenting cells and promotes resistance to Salmonella infection. Wilson TJ, Clare S, Mikulin J, Johnson CM, Harcourt K, Lyons PA, Dougan G, Smith KGC. Immunology. 2020 Apr;159(4):393-403. doi: 10.1111/imm.13169. Epub 2020 Jan 28. PubMed |
| Injectable, scalable 3D tissue-engineered model of marrow hematopoiesis. Tavakol DN, Tratwal J, Bonini F, Genta M, Campos V, Burch P, Hoehnel S, Beduer A, Alessandrini M, Naveiras O, Braschler T. Biomaterials. 2020 Feb;232:119665. doi: 10.1016/j.biomaterials.2019.119665. Epub 2019 Dec 11. PubMed |
| Oncogenic K-ras Induces Mitochondrial OPA3 Expression to Promote Energy Metabolism in Pancreatic Cancer Cells. Meng N, Glorieux C, Zhang Y, Liang L, Zeng P, Lu W, Huang P. Cancers (Basel). 2019 Dec 25;12(1). pii: cancers12010065. doi: 10.3390/cancers12010065. PubMed |
| Efficient Modulation of TP53 Expression in Human Induced Pluripotent Stem Cells. Uhlmann C, Kuhn LM, Tigges J, Fritsche E, Kahlert UD. Curr Protoc Stem Cell Biol. 2020 Mar;52(1):e102. doi: 10.1002/cpsc.102. PubMed |
| CDK7 Inhibition Potentiates Genome Instability Triggering Anti-tumor Immunity in Small Cell Lung Cancer. Zhang H, Christensen CL, Dries R, Oser MG, Deng J, Diskin B, Li F, Pan Y, Zhang X, Yin Y, Papadopoulos E, Pyon V, Thakurdin C, Kwiatkowski N, Jani K, Rabin AR, Castro DM, Chen T, Silver H, Huang Q, Bulatovic M, Dowling CM, Sundberg B, Leggett A, Ranieri M, Han H, Li S, Yang A, Labbe KE, Almonte C, Sviderskiy VO, Quinn M, Donaghue J, Wang ES, Zhang T, He Z, Velcheti V, Hammerman PS, Freeman GJ, Bonneau R, Kaelin WG Jr, Sutherland KD, Kersbergen A, Aguirre AJ, Yuan GC, Rothenberg E, Miller G, Gray NS, Wong KK. Cancer Cell. 2020 Jan 13;37(1):37-54.e9. doi: 10.1016/j.ccell.2019.11.003. Epub 2019 Dec 26. PubMed |
| Fumarate and oxidative stress synergize to promote stability of C/EBP homologous protein in the adipocyte. Manuel AM, Walla MD, Dorn MT, Tanis RM, Piroli GG, Frizzell N. Free Radic Biol Med. 2020 Feb 20;148:70-82. doi: 10.1016/j.freeradbiomed.2019.12.037. Epub 2019 Dec 26. PubMed |
| Sonogenetic Modulation of Cellular Activities Using an Engineered Auditory-Sensing Protein. Huang YS, Fan CH, Hsu N, Chiu NH, Wu CY, Chang CY, Wu BH, Hong SR, Chang YC, Yan-Tang Wu A, Guo V, Chiang YC, Hsu WC, Chen L, Pin-Kuang Lai C, Yeh CK, Lin YC. Nano Lett. 2020 Feb 12;20(2):1089-1100. doi: 10.1021/acs.nanolett.9b04373. Epub 2020 Jan 2. PubMed |
| A solid-phase transfection platform for arrayed CRISPR screens. Sercin O, Reither S, Roidos P, Ballin N, Palikyras S, Baginska A, Rein K, Llamazares M, Halavatyi A, Winter H, Muley T, Jurkowska RZ, Abdollahi A, Zenke FT, Neumann B, Mardin BR. Mol Syst Biol. 2019 Dec;15(12):e8983. doi: 10.15252/msb.20198983. PubMed |
| Genes Involved in the Transcriptional Regulation of Pluripotency Are Expressed in Malignant Tumors of the Uterine Cervix and Can Induce Tumorigenic Capacity in a Nontumorigenic Cell Line. Ruiz G, Valencia-Gonzalez HA, Perez-Montiel D, Munoz F, Ocadiz-Delgado R, Fernandez-Retana J, Perez-Plasencia C, Resendis-Antonio O, Gariglio P, Garcia-Carranca A. Stem Cells Int. 2019 Dec 1;2019:7683817. doi: 10.1155/2019/7683817. eCollection 2019. PubMed |
| Deuterium Tracing to Interrogate Compartment-Specific NAD(P)H Metabolism in Cultured Mammalian Cells. Lim EW, Parker SJ, Metallo CM. Methods Mol Biol. 2020;2088:51-71. doi: 10.1007/978-1-0716-0159-4_4. PubMed |
| Frizzled 1 and Wnt1 as new potential therapeutic targets in the traumatically injured spinal cord. Gonzalez P, Gonzalez-Fernandez C, Campos-Martin Y, Mollejo M, Carballosa-Gautam M, Marcillo A, Norenberg M, Rodriguez FJ. Cell Mol Life Sci. 2020 Jan 3. pii: 10.1007/s00018-019-03427-4. doi: 10.1007/s00018-019-03427-4. PubMed |
| Epigenetic priming by Dot1l in lymphatic endothelial progenitors ensures normal lymphatic development and function. Yoo H, Lee YJ, Park C, Son D, Choi DY, Park JH, Choi HJ, La HW, Choi YJ, Moon EH, Saur D, Chung HM, Song H, Do JT, Jang H, Lee DR, Park C, Lee OH, Cho SG, Hong SH, Kong G, Kim JH, Choi Y, Hong K. Cell Death Dis. 2020 Jan 6;11(1):14. doi: 10.1038/s41419-019-2201-1. PubMed |
| Respiratory supercomplexes act as a platform for complex III-mediated maturation of human mitochondrial complexes I and IV. Protasoni M, Perez-Perez R, Lobo-Jarne T, Harbour ME, Ding S, Penas A, Diaz F, Moraes CT, Fearnley IM, Zeviani M, Ugalde C, Fernandez-Vizarra E. EMBO J. 2020 Feb 3;39(3):e102817. doi: 10.15252/embj.2019102817. Epub 2020 Jan 8. PubMed |
| YAP regulates cell size and growth dynamics via non-cell autonomous mediators. Mugahid D, Kalocsay M, Liu X, Gruver JS, Peshkin L, Kirschner MW. Elife. 2020 Jan 9;9. pii: 53404. doi: 10.7554/eLife.53404. PubMed |
| Outside-in regulation of the readily releasable pool of synaptic vesicles by alpha2delta-1. Martinez San Segundo P, Terni B, Burgueno J, Monroy X, Dordal A, Merlos M, Llobet A. FASEB J. 2020 Jan;34(1):1362-1377. doi: 10.1096/fj.201901551R. Epub 2019 Nov 30. PubMed |
| CRISPR-Cas9-induced IGF1 gene activation as a tool for enhancing muscle differentiation via multiple isoform expression. Roberston MJ, Raghunathan S, Potaman VN, Zhang F, Stewart MD, McConnell BK, Schwartz RJ. FASEB J. 2020 Jan;34(1):555-570. doi: 10.1096/fj.201901107RR. Epub 2019 Nov 25. PubMed |
| Species-specific consequences of an E40K missense mutation in superoxide dismutase 1 (SOD1). Draper ACE, Wilson Z, Maile C, Faccenda D, Campanella M, Piercy RJ. FASEB J. 2020 Jan;34(1):458-473. doi: 10.1096/fj.201901455R. Epub 2019 Nov 25. PubMed |
| Transcription factor NRF2 uses the Hippo pathway effector TAZ to induce tumorigenesis in glioblastomas. Escoll M, Lastra D, Pajares M, Robledinos-Anton N, Rojo AI, Fernandez-Gines R, Mendiola M, Martinez-Marin V, Esteban I, Lopez-Larrubia P, Gargini R, Cuadrado A. Redox Biol. 2020 Feb;30:101425. doi: 10.1016/j.redox.2019.101425. Epub 2020 Jan 2. PubMed |
A fluorescence activatable reporter of flavivirus NS2B-NS3 protease activity enables live imaging of infection in single cells and viral plaques.
Arias-Arias JL, MacPherson DJ, Hill ME, Hardy JA, Mora-Rodriguez R.
J Biol Chem. 2020 Jan 9. pii: RA119.011319. doi: 10.1074/jbc.RA119.011319.
PubMed
Associated Plasmids |
| Efficient and Robust NK-Cell Transduction With Baboon Envelope Pseudotyped Lentivector. Colamartino ABL, Lemieux W, Bifsha P, Nicoletti S, Chakravarti N, Sanz J, Romero H, Selleri S, Beland K, Guiot M, Tremblay-Laganiere C, Dicaire R, Barreiro L, Lee DA, Verhoeyen E, Haddad E. Front Immunol. 2019 Dec 16;10:2873. doi: 10.3389/fimmu.2019.02873. eCollection 2019. PubMed |
| Artificial escape from XCI by DNA methylation editing of the CDKL5 gene. Halmai JANM, Deng P, Gonzalez CE, Coggins NB, Cameron D, Carter JL, Buchanan FKB, Waldo JJ, Lock SR, Anderson JD, O'Geen H, Segal DJ, Nolta J, Fink KD. Nucleic Acids Res. 2020 Mar 18;48(5):2372-2387. doi: 10.1093/nar/gkz1214. PubMed |
| On-chip 3D neuromuscular model for drug screening and precision medicine in neuromuscular disease. Osaki T, Uzel SGM, Kamm RD. Nat Protoc. 2020 Feb;15(2):421-449. doi: 10.1038/s41596-019-0248-1. Epub 2020 Jan 13. PubMed |
| CRISPR/Cas9-Based Genetic Screening to Study T-Cell Function. Shang W, Wang F, Zhu Q, Wang L, Wang H. Methods Mol Biol. 2020;2111:59-70. doi: 10.1007/978-1-0716-0266-9_5. PubMed |
| Increased expression of O-GlcNAc transferase (OGT) is a biomarker for poor prognosis and allows tumorigenesis and invasion in colon cancer. Xu D, Wang W, Bian T, Yang W, Shao M, Yang H. Int J Clin Exp Pathol. 2019 Apr 1;12(4):1305-1314. eCollection 2019. PubMed |
| Epidermal autonomous VEGFA/Flt1/Nrp1 functions mediate psoriasis-like disease. Benhadou F, Glitzner E, Brisebarre A, Swedlund B, Song Y, Dubois C, Rozzi M, Paulissen C, Del Marmol V, Sibilia M, Blanpain C. Sci Adv. 2020 Jan 8;6(2):eaax5849. doi: 10.1126/sciadv.aax5849. eCollection 2020 Jan. PubMed |
| Inhibition of PP2A with LB-100 Enhances Efficacy of CAR-T Cell Therapy Against Glioblastoma. Cui J, Wang H, Medina R, Zhang Q, Xu C, Indig IH, Zhou J, Song Q, Dmitriev P, Sun MY, Guo L, Wang Y, Rosenblum JS, Kovach JS, Gilbert MR, Zhuang Z. Cancers (Basel). 2020 Jan 6;12(1). pii: cancers12010139. doi: 10.3390/cancers12010139. PubMed |
| Oxygen-dependent asparagine hydroxylation of the ubiquitin-associated (UBA) domain in Cezanne regulates ubiquitin binding. Mader J, Huber J, Bonn F, Dotsch V, Rogov VV, Bremm A. J Biol Chem. 2020 Feb 21;295(8):2160-2174. doi: 10.1074/jbc.RA119.010315. Epub 2020 Jan 14. PubMed |
| Effects of Benzophenone-3 and Propylparaben on Estrogen Receptor-Dependent R-Loops and DNA Damage in Breast Epithelial Cells and Mice. Majhi PD, Sharma A, Roberts AL, Daniele E, Majewski AR, Chuong LM, Black AL, Vandenberg LN, Schneider SS, Dunphy KA, Jerry DJ. Environ Health Perspect. 2020 Jan;128(1):17002. doi: 10.1289/EHP5221. Epub 2020 Jan 15. PubMed |
| The vitamin D receptor regulates mitochondrial function in C2C12 myoblasts. Ashcroft SP, Bass JJ, Kazi AA, Atherton PJ, Philp A. Am J Physiol Cell Physiol. 2020 Mar 1;318(3):C536-C541. doi: 10.1152/ajpcell.00568.2019. Epub 2020 Jan 15. PubMed |
| The EGFR-TMEM167A-p53 Axis Defines the Aggressiveness of Gliomas. Segura-Collar B, Gargini R, Tovar-Ambel E, Hernandez-SanMiguel E, Epifano C, Perez de Castro I, Hernandez-Lain A, Casas-Tinto S, Sanchez-Gomez P. Cancers (Basel). 2020 Jan 14;12(1). pii: cancers12010208. doi: 10.3390/cancers12010208. PubMed |
| The Relative Permittivity Changes of EGF by 50 Hz MF Exposure Neither Affect the Interaction of EGF With EGFR Nor Its Biological Effects. Fei Y, Jin Y, Zhao X, Wang Y, Qian J, Su L, Chen G. Bioelectromagnetics. 2020 Apr;41(3):241-246. doi: 10.1002/bem.22249. Epub 2020 Jan 17. PubMed |
| High-Throughput Screening Identifies Two Novel Small Molecule Enhancers of Recombinant Protein Expression. Chang J, Chen X, Wang R, Shi R, Wang X, Lu W, Ma S, Xia Q. Molecules. 2020 Jan 15;25(2). pii: molecules25020353. doi: 10.3390/molecules25020353. PubMed |
| An ultra-stable cytoplasmic antibody engineered for in vivo applications. Kabayama H, Takeuchi M, Tokushige N, Muramatsu SI, Kabayama M, Fukuda M, Yamada Y, Mikoshiba K. Nat Commun. 2020 Jan 17;11(1):336. doi: 10.1038/s41467-019-13654-9. PubMed |
| Genome-wide CRISPR-Cas9 screening reveals ubiquitous T cell cancer targeting via the monomorphic MHC class I-related protein MR1. Crowther MD, Dolton G, Legut M, Caillaud ME, Lloyd A, Attaf M, Galloway SAE, Rius C, Farrell CP, Szomolay B, Ager A, Parker AL, Fuller A, Donia M, McCluskey J, Rossjohn J, Svane IM, Phillips JD, Sewell AK. Nat Immunol. 2020 Feb;21(2):178-185. doi: 10.1038/s41590-019-0578-8. Epub 2020 Jan 20. PubMed |
| Reprogramming Fibroblasts to Neural Stem Cells by Overexpression of the Transcription Factor Ptf1a. Jin K, Zou M, Xiao D, Xiang M. Methods Mol Biol. 2020;2117:245-263. doi: 10.1007/978-1-0716-0301-7_15. PubMed |
| Rare and private spliceosomal gene mutations drive partial, complete, and dual phenocopies of hotspot alterations. Pangallo J, Kiladjian JJ, Cassinat B, Renneville A, Taylor J, Polaski JT, North K, Abdel-Wahab O, Bradley RK. Blood. 2020 Mar 26;135(13):1032-1043. doi: 10.1182/blood.2019002894. PubMed |
| Investigating Chaperonin-Containing TCP-1 subunit 2 as an essential component of the chaperonin complex for tumorigenesis. Showalter AE, Martini AC, Nierenberg D, Hosang K, Fahmi NA, Gopalan P, Khaled AS, Zhang W, Khaled AR. Sci Rep. 2020 Jan 21;10(1):798. doi: 10.1038/s41598-020-57602-w. PubMed |
| Silencing of SENP2 in Multiple Myeloma Induces Bortezomib Resistance by Activating NF-kappaB Through the Modulation of IkappaBalpha Sumoylation. Xie H, Gu Y, Wang W, Wang X, Ye X, Xin C, Lu M, Reddy BA, Shu P. Sci Rep. 2020 Jan 21;10(1):766. doi: 10.1038/s41598-020-57698-0. PubMed |
| Lentiviral Vector Production Titer Is Not Limited in HEK293T by Induced Intracellular Innate Immunity. Ferreira CB, Sumner RP, Rodriguez-Plata MT, Rasaiyaah J, Milne RS, Thrasher AJ, Qasim W, Towers GJ. Mol Ther Methods Clin Dev. 2019 Dec 24;17:209-219. doi: 10.1016/j.omtm.2019.11.021. eCollection 2020 Jun 12. PubMed |
| CXCL12-induced rescue of cortical dendritic spines and cognitive flexibility. Festa LK, Irollo E, Platt BJ, Tian Y, Floresco S, Meucci O. Elife. 2020 Jan 23;9. pii: 49717. doi: 10.7554/eLife.49717. PubMed |
| A role for ceramide glycosylation in resistance to oxaliplatin in colorectal cancer. Madigan JP, Robey RW, Poprawski JE, Huang H, Clarke CJ, Gottesman MM, Cabot MC, Rosenberg DW. Exp Cell Res. 2020 Mar 15;388(2):111860. doi: 10.1016/j.yexcr.2020.111860. Epub 2020 Jan 20. PubMed |
| Noncoding mutations target cis-regulatory elements of the FOXA1 plexus in prostate cancer. Zhou S, Hawley JR, Soares F, Grillo G, Teng M, Madani Tonekaboni SA, Hua JT, Kron KJ, Mazrooei P, Ahmed M, Arlidge C, Yun HY, Livingstone J, Huang V, Yamaguchi TN, Espiritu SMG, Zhu Y, Severson TM, Murison A, Cameron S, Zwart W, van der Kwast T, Pugh TJ, Fraser M, Boutros PC, Bristow RG, He HH, Lupien M. Nat Commun. 2020 Jan 23;11(1):441. doi: 10.1038/s41467-020-14318-9. PubMed |
| Restoring Wnt6 signaling ameliorates behavioral deficits in MeCP2 T158A mouse model of Rett syndrome. Hsu WL, Ma YL, Liu YC, Tai DJC, Lee EHY. Sci Rep. 2020 Jan 23;10(1):1074. doi: 10.1038/s41598-020-57745-w. PubMed |
| A CRISPR/Cas9 genome editing pipeline in the EndoC-betaH1 cell line to study genes implicated in beta cell function. Grotz AK, Abaitua F, Navarro-Guerrero E, Hastoy B, Ebner D, Gloyn AL. Wellcome Open Res. 2020 Apr 29;4:150. doi: 10.12688/wellcomeopenres.15447.2. eCollection 2019. PubMed |
| scMAGeCK links genotypes with multiple phenotypes in single-cell CRISPR screens. Yang L, Zhu Y, Yu H, Cheng X, Chen S, Chu Y, Huang H, Zhang J, Li W. Genome Biol. 2020 Jan 24;21(1):19. doi: 10.1186/s13059-020-1928-4. PubMed |
IL-4 controls activated neutrophil FcgammaR2b expression and migration into inflamed joints.
Panda SK, Wigerblad G, Jiang L, Jimenez-Andrade Y, Iyer VS, Shen Y, Boddul SV, Guerreiro-Cacais AO, Raposo B, Kasza Z, Wermeling F.
Proc Natl Acad Sci U S A. 2020 Jan 24. pii: 1914186117. doi: 10.1073/pnas.1914186117.
PubMed
Associated Plasmids |
ATP13A2 deficiency disrupts lysosomal polyamine export.
van Veen S, Martin S, Van den Haute C, Benoy V, Lyons J, Vanhoutte R, Kahler JP, Decuypere JP, Gelders G, Lambie E, Zielich J, Swinnen JV, Annaert W, Agostinis P, Ghesquiere B, Verhelst S, Baekelandt V, Eggermont J, Vangheluwe P.
Nature. 2020 Feb;578(7795):419-424. doi: 10.1038/s41586-020-1968-7. Epub 2020 Jan 29.
PubMed
Associated Plasmids |
| WDR5 is a conserved regulator of protein synthesis gene expression. Bryan AF, Wang J, Howard GC, Guarnaccia AD, Woodley CM, Aho ER, Rellinger EJ, Matlock BK, Flaherty DK, Lorey SL, Chung DH, Fesik SW, Liu Q, Weissmiller AM, Tansey WP. Nucleic Acids Res. 2020 Apr 6;48(6):2924-2941. doi: 10.1093/nar/gkaa051. PubMed |
| The m6A reader YTHDF1 promotes ovarian cancer progression via augmenting EIF3C translation. Liu T, Wei Q, Jin J, Luo Q, Liu Y, Yang Y, Cheng C, Li L, Pi J, Si Y, Xiao H, Li L, Rao S, Wang F, Yu J, Yu J, Zou D, Yi P. Nucleic Acids Res. 2020 Apr 17;48(7):3816-3831. doi: 10.1093/nar/gkaa048. PubMed |
| Protein tyrosine phosphatase 4A3 (PTP4A3/PRL-3) drives migration and progression of T-cell acute lymphoblastic leukemia in vitro and in vivo. Wei M, Haney MG, Rivas DR, Blackburn JS. Oncogenesis. 2020 Jan 30;9(1):6. doi: 10.1038/s41389-020-0192-5. PubMed |
| Tumor heterogeneity and clonal cooperation influence the immune selection of IFN-gamma-signaling mutant cancer cells. Williams JB, Li S, Higgs EF, Cabanov A, Wang X, Huang H, Gajewski TF. Nat Commun. 2020 Jan 30;11(1):602. doi: 10.1038/s41467-020-14290-4. PubMed |
| KANSL2 and MBNL3 are regulators of pancreatic ductal adenocarcinoma invasion. Oladimeji PO, Bakke J, Wright WC, Chen T. Sci Rep. 2020 Jan 30;10(1):1485. doi: 10.1038/s41598-020-58448-y. PubMed |
| Serine phosphorylation of the small phosphoprotein ICAP1 inhibits its nuclear accumulation. Su VL, Simon B, Draheim KM, Calderwood DA. J Biol Chem. 2020 Mar 6;295(10):3269-3284. doi: 10.1074/jbc.RA119.009794. Epub 2020 Jan 31. PubMed |
| Loss of hnRNPA2B1 inhibits malignant capability and promotes apoptosis via down-regulating Lin28B expression in ovarian cancer. Yang Y, Wei Q, Tang Y, Yuanyuan Wang, Luo Q, Zhao H, He M, Wang H, Zeng Q, Lu W, Xu J, Liu T, Yi P. Cancer Lett. 2020 Apr 10;475:43-52. doi: 10.1016/j.canlet.2020.01.029. Epub 2020 Jan 29. PubMed |
| Inhibition of the deubiquitinase USP10 induces degradation of SYK. Yang J, Meng C, Weisberg E, Case A, Lamberto I, Magin RS, Adamia S, Wang J, Gray N, Liu S, Stone R, Sattler M, Buhrlage S, Griffin JD. Br J Cancer. 2020 Apr;122(8):1175-1184. doi: 10.1038/s41416-020-0731-z. Epub 2020 Feb 4. PubMed |
| Modulation of sulfur assimilation metabolic toxicity overcomes anemia and hemochromatosis in mice. Hale AT, Brown RE, Luka Z, Hudson BH, Matta P, Williams CS, York JD. Adv Biol Regul. 2020 May;76:100694. doi: 10.1016/j.jbior.2020.100694. Epub 2020 Jan 26. PubMed |
| CRISPR/Cas9 increases mitotic gene conversion in human cells. Javidi-Parsijani P, Lyu P, Makani V, Sarhan WM, Yoo KW, El-Korashi L, Atala A, Lu B. Gene Ther. 2020 Jun;27(6):281-296. doi: 10.1038/s41434-020-0126-z. Epub 2020 Feb 4. PubMed |
| MTR4 drives liver tumorigenesis by promoting cancer metabolic switch through alternative splicing. Yu L, Kim J, Jiang L, Feng B, Ying Y, Ji KY, Tang Q, Chen W, Mai T, Dou W, Zhou J, Xiang LY, He YF, Yang D, Li Q, Fu X, Xu Y. Nat Commun. 2020 Feb 5;11(1):708. doi: 10.1038/s41467-020-14437-3. PubMed |
| Tissue-specific promoter-based reporter system for monitoring cell differentiation from iPSCs to cardiomyocytes. Fiedorowicz K, Rozwadowska N, Zimna A, Malcher A, Tutak K, Szczerbal I, Nowicka-Bauer K, Nowaczyk M, Kolanowski TJ, Labedz W, Kubaszewski L, Kurpisz M. Sci Rep. 2020 Feb 5;10(1):1895. doi: 10.1038/s41598-020-58050-2. PubMed |
| A novel NanoBiT-based assay monitors the interaction between lipoprotein lipase and GPIHBP1 in real time. Shetty SK, Walzem RL, Davies BSJ. J Lipid Res. 2020 Apr;61(4):546-559. doi: 10.1194/jlr.D119000388. Epub 2020 Feb 6. PubMed |
| Synergistic lethality between PARP-trapping and alantolactone-induced oxidative DNA damage in homologous recombination-proficient cancer cells. Wang H, Zhang S, Song L, Qu M, Zou Z. Oncogene. 2020 Apr;39(14):2905-2920. doi: 10.1038/s41388-020-1191-x. Epub 2020 Feb 6. PubMed |
| Roscovitine enhances All-trans retinoic acid (ATRA)-induced leukemia cell differentiation: Novel effects on signaling molecules for a putative Cdk2 inhibitor. Rashid A, Duan X, Gao F, Yang M, Yen A. Cell Signal. 2020 Jul;71:109555. doi: 10.1016/j.cellsig.2020.109555. Epub 2020 Feb 4. PubMed |
| Successfully transfected primary peripherally mobilized human CD34+ hematopoietic stem and progenitor cells (HSPCs) demonstrate increased susceptibility to retroviral infection. Sebrow J, Goff SP, Griffin DO. Virol J. 2020 Feb 10;17(1):22. doi: 10.1186/s12985-020-1297-3. PubMed |
| BRCA1 and S phase DNA repair pathways restrict LINE-1 retrotransposition in human cells. Mita P, Sun X, Fenyo D, Kahler DJ, Li D, Agmon N, Wudzinska A, Keegan S, Bader JS, Yun C, Boeke JD. Nat Struct Mol Biol. 2020 Feb;27(2):179-191. doi: 10.1038/s41594-020-0374-z. Epub 2020 Feb 10. PubMed |
| Blunted Vagal Cocaine- and Amphetamine-Regulated Transcript Promotes Hyperphagia and Weight Gain. Lee SJ, Krieger JP, Vergara M, Quinn D, McDougle M, de Araujo A, Darling R, Zollinger B, Anderson S, Pan A, Simonnet EJ, Pignalosa A, Arnold M, Singh A, Langhans W, Raybould HE, de Lartigue G. Cell Rep. 2020 Feb 11;30(6):2028-2039.e4. doi: 10.1016/j.celrep.2020.01.045. PubMed |
| Inhibition of USP9X Downregulates JAK2-V617F and Induces Apoptosis Synergistically with BH3 Mimetics Preferentially in Ruxolitinib-Persistent JAK2-V617F-Positive Leukemic Cells. Akiyama H, Umezawa Y, Watanabe D, Okada K, Ishida S, Nogami A, Miura O. Cancers (Basel). 2020 Feb 10;12(2). pii: cancers12020406. doi: 10.3390/cancers12020406. PubMed |
Mechanical regulation of glycolysis via cytoskeleton architecture.
Park JS, Burckhardt CJ, Lazcano R, Solis LM, Isogai T, Li L, Chen CS, Gao B, Minna JD, Bachoo R, DeBerardinis RJ, Danuser G.
Nature. 2020 Feb 12. pii: 10.1038/s41586-020-1998-1. doi: 10.1038/s41586-020-1998-1.
PubMed
Associated Plasmids |
| Cell-Penetrating Nanoparticles Activate the Inflammasome to Enhance Antibody Production by Targeting Microtubule-Associated Protein 1-Light Chain 3 for Degradation. Zhu M, Du L, Zhao R, Wang HY, Zhao Y, Nie G, Wang RF. ACS Nano. 2020 Mar 24;14(3):3703-3717. doi: 10.1021/acsnano.0c00962. Epub 2020 Feb 20. PubMed |
| Interleukin-10 delivered by mesenchymal stem cells attenuates experimental autoimmune myocarditis. Shao M, Wang D, Zhou Y, Du K, Liu W. Int Immunopharmacol. 2020 Apr;81:106212. doi: 10.1016/j.intimp.2020.106212. Epub 2020 Feb 13. PubMed |
| In Vivo Augmentation of Gut-Homing Regulatory T Cell Induction. Bi H, Wasnik S, Baylink DJ, Liu C, Tang X. J Vis Exp. 2020 Jan 22;(155). doi: 10.3791/60585. PubMed |
| Culture, Manipulation, and Orthotopic Transplantation of Mouse Bladder Tumor Organoids. Kim Y, Lee J, Kim S, Shin K. J Vis Exp. 2020 Jan 31;(155). doi: 10.3791/60469. PubMed |
| Endogenous Retrovirus Activation as a Key Mechanism of Anti-Tumor Immune Response in Radiotherapy. Lee AK, Pan D, Bao X, Hu M, Li F, Li CY. Radiat Res. 2020 Apr;193(4):305-317. doi: 10.1667/RADE-20-00013. Epub 2020 Feb 19. PubMed |
| AMPK activation does not enhance autophagy in neurons in contrast to MTORC1 inhibition: different impact on beta-amyloid clearance. Benito-Cuesta I, Ordonez-Gutierrez L, Wandosell F. Autophagy. 2021 Mar;17(3):656-671. doi: 10.1080/15548627.2020.1728095. Epub 2020 Feb 20. PubMed |
| Lineage reprogramming of fibroblasts into induced cardiac progenitor cells by CRISPR/Cas9-based transcriptional activators. Wang J, Jiang X, Zhao L, Zuo S, Chen X, Zhang L, Lin Z, Zhao X, Qin Y, Zhou X, Yu XY. Acta Pharm Sin B. 2020 Feb;10(2):313-326. doi: 10.1016/j.apsb.2019.09.003. Epub 2019 Sep 17. PubMed |
| Belinostat resolves skin barrier defects in atopic dermatitis by targeting the dysregulated miR-335:SOX6 axis. Liew WC, Sundaram GM, Quah S, Lum GG, Tan JSL, Ramalingam R, Common JEA, Tang MBY, Lane EB, Thng STG, Sampath P. J Allergy Clin Immunol. 2020 Feb 21. pii: S0091-6749(20)30259-1. doi: 10.1016/j.jaci.2020.02.007. PubMed |
| Association of BRCA Mutations and BRCAness Status With Anticancer Drug Sensitivities in Triple-Negative Breast Cancer Cell Lines Teraoka S, Muguruma M, Takano N, Miyahara K, Kawate T, Kaise H, Yamada K, Miyazawa K, Ishikawa T. J Surg Res. 2020 Jun;250:200-208. doi: 10.1016/j.jss.2019.12.040. Epub 2020 Feb 21. PubMed |
| Studies of Non-Protective Autophagy Provide Evidence that Recovery from Therapy-Induced Senescence is Independent of Early Autophagy. Saleh T, Tyutyunyk-Massey L, Patel NH, Cudjoe EK Jr, Alotaibi M, Gewirtz DA. Int J Mol Sci. 2020 Feb 20;21(4). pii: ijms21041427. doi: 10.3390/ijms21041427. PubMed |
| Optimization of recombinant Zika virus NS1 protein secretion from HEK293 cells. Roldan JS, Cassola A, Castillo DS. Biotechnol Rep (Amst). 2020 Feb 11;25:e00434. doi: 10.1016/j.btre.2020.e00434. eCollection 2020 Mar. PubMed |
| MYC Regulation of D2HGDH and L2HGDH Influences the Epigenome and Epitranscriptome. Qiu Z, Lin AP, Jiang S, Elkashef SM, Myers J, Srikantan S, Sasi B, Cao JZ, Godley LA, Rakheja D, Lyu Y, Zheng S, Madesh M, Shiio Y, Dahia PLM, Aguiar RCT. Cell Chem Biol. 2020 May 21;27(5):538-550.e7. doi: 10.1016/j.chembiol.2020.02.002. Epub 2020 Feb 25. PubMed |
| NOTCH4 maintains quiescent mesenchymal-like breast cancer stem cells via transcriptionally activating SLUG and GAS1 in triple-negative breast cancer. Zhou L, Wang D, Sheng D, Xu J, Chen W, Qin Y, Du R, Yang X, He X, Xie N, Liu S, Zhang L. Theranostics. 2020 Jan 19;10(5):2405-2421. doi: 10.7150/thno.38875. eCollection 2020. PubMed |
| Caloric Restriction Reprograms the Single-Cell Transcriptional Landscape of Rattus Norvegicus Aging. Ma S, Sun S, Geng L, Song M, Wang W, Ye Y, Ji Q, Zou Z, Wang S, He X, Li W, Esteban CR, Long X, Guo G, Chan P, Zhou Q, Belmonte JCI, Zhang W, Qu J, Liu GH. Cell. 2020 Mar 5;180(5):984-1001.e22. doi: 10.1016/j.cell.2020.02.008. Epub 2020 Feb 27. PubMed |
| Mutation-Dependent Pathomechanisms Determine the Phenotype in the Bestrophinopathies. Nachtigal AL, Milenkovic A, Brandl C, Schulz HL, Duerr LMJ, Lang GE, Reiff C, Herrmann P, Kellner U, Weber BHF. Int J Mol Sci. 2020 Feb 26;21(5). pii: ijms21051597. doi: 10.3390/ijms21051597. PubMed |
| Acid Ceramidase Depletion Impairs Neuronal Survival and Induces Morphological Defects in Neurites Associated with Altered Gene Transcription and Sphingolipid Content. Kyriakou K, Lederer CW, Kleanthous M, Drousiotou A, Malekkou A. Int J Mol Sci. 2020 Feb 26;21(5). pii: ijms21051607. doi: 10.3390/ijms21051607. PubMed |
| A CRISPR-Cas9-based reporter system for single-cell detection of extracellular vesicle-mediated functional transfer of RNA. de Jong OG, Murphy DE, Mager I, Willms E, Garcia-Guerra A, Gitz-Francois JJ, Lefferts J, Gupta D, Steenbeek SC, van Rheenen J, El Andaloussi S, Schiffelers RM, Wood MJA, Vader P. Nat Commun. 2020 Feb 28;11(1):1113. doi: 10.1038/s41467-020-14977-8. PubMed |
| Ligand-dependent internalization of Bombyx mori tachykinin-related peptide receptor is regulated by PKC, GRK5 and beta-arrestin2/BmKurtz. He X, Yan L, Wu Q, Zhang G, Zhou N. Biochim Biophys Acta Mol Cell Res. 2020 Jun;1867(6):118690. doi: 10.1016/j.bbamcr.2020.118690. Epub 2020 Feb 26. PubMed |
| Saccharide analog, 2-deoxy-d-glucose enhances 4-1BB-mediated antitumor immunity via PD-L1 deglycosylation. Kim B, Sun R, Oh W, Kim AMJ, Schwarz JR, Lim SO. Mol Carcinog. 2020 Jul;59(7):691-700. doi: 10.1002/mc.23170. Epub 2020 Mar 1. PubMed |
| The E3 Ubiquitin Ligase SIAH1 Targets MyD88 for Proteasomal Degradation During Dengue Virus Infection. Murphy Schafer AR, Smith JL, Pryke KM, DeFilippis VR, Hirsch AJ. Front Microbiol. 2020 Feb 14;11:24. doi: 10.3389/fmicb.2020.00024. eCollection 2020. PubMed |
| A Preclinical Embryonic Zebrafish Xenograft Model to Investigate CAR T Cells In Vivo. Pascoal S, Salzer B, Scheuringer E, Wenninger-Weinzierl A, Sturtzel C, Holter W, Taschner-Mandl S, Lehner M, Distel M. Cancers (Basel). 2020 Feb 29;12(3). pii: cancers12030567. doi: 10.3390/cancers12030567. PubMed |
| gscreend: modelling asymmetric count ratios in CRISPR screens to decrease experiment size and improve phenotype detection. Imkeller K, Ambrosi G, Boutros M, Huber W. Genome Biol. 2020 Mar 2;21(1):53. doi: 10.1186/s13059-020-1939-1. PubMed |
| Plakophilin 3 phosphorylation by ribosomal S6 kinases supports desmosome assembly. Muller L, Rietscher K, Keil R, Neuholz M, Hatzfeld M. J Cell Sci. 2020 Apr 16;133(8). pii: jcs.238295. doi: 10.1242/jcs.238295. PubMed |
| Patient-derived small intestinal myofibroblasts direct perfused, physiologically responsive capillary development in a microfluidic Gut-on-a-Chip Model. Seiler KM, Bajinting A, Alvarado DM, Traore MA, Binkley MM, Goo WH, Lanik WE, Ou J, Ismail U, Iticovici M, King CR, VanDussen KL, Swietlicki EA, Gazit V, Guo J, Luke CJ, Stappenbeck T, Ciorba MA, George SC, Meacham JM, Rubin DC, Good M, Warner BW. Sci Rep. 2020 Mar 2;10(1):3842. doi: 10.1038/s41598-020-60672-5. PubMed |
| Bacteria Boost Mammalian Host NAD Metabolism by Engaging the Deamidated Biosynthesis Pathway. Shats I, Williams JG, Liu J, Makarov MV, Wu X, Lih FB, Deterding LJ, Lim C, Xu X, Randall TA, Lee E, Li W, Fan W, Li JL, Sokolsky M, Kabanov AV, Li L, Migaud ME, Locasale JW, Li X. Cell Metab. 2020 Mar 3;31(3):564-579.e7. doi: 10.1016/j.cmet.2020.02.001. PubMed |
High-Throughput Screens of PAM-Flexible Cas9 Variants for Gene Knockout and Transcriptional Modulation.
Legut M, Daniloski Z, Xue X, McKenzie D, Guo X, Wessels HH, Sanjana NE.
Cell Rep. 2020 Mar 3;30(9):2859-2868.e5. doi: 10.1016/j.celrep.2020.02.010.
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Associated Plasmids
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| Early B Cell Factor Activity Controls Developmental and Adaptive Thermogenic Gene Programming in Adipocytes. Angueira AR, Shapira SN, Ishibashi J, Sampat S, Sostre-Colon J, Emmett MJ, Titchenell PM, Lazar MA, Lim HW, Seale P. Cell Rep. 2020 Mar 3;30(9):2869-2878.e4. doi: 10.1016/j.celrep.2020.02.023. PubMed |
| Challenges and Reinterpretation of Antibody-Based Research on Phosphorylation of Tyr(307) on PP2Ac. Mazhar S, Leonard D, Sosa A, Schlatzer D, Thomas D, Narla G. Cell Rep. 2020 Mar 3;30(9):3164-3170.e3. doi: 10.1016/j.celrep.2020.02.012. PubMed |
| Therapeutic potential of KLF2-induced exosomal microRNAs in pulmonary hypertension. Sindi HA, Russomanno G, Satta S, Abdul-Salam VB, Jo KB, Qazi-Chaudhry B, Ainscough AJ, Szulcek R, Jan Bogaard H, Morgan CC, Pullamsetti SS, Alzaydi MM, Rhodes CJ, Piva R, Eichstaedt CA, Grunig E, Wilkins MR, Wojciak-Stothard B. Nat Commun. 2020 Mar 4;11(1):1185. doi: 10.1038/s41467-020-14966-x. PubMed |
| Locally acting transcription factors regulate p53-dependent cis-regulatory element activity. Catizone AN, Uzunbas GK, Celadova P, Kuang S, Bose D, Sammons MA. Nucleic Acids Res. 2020 May 7;48(8):4195-4213. doi: 10.1093/nar/gkaa147. PubMed |
| Serine Biosynthesis Pathway Supports MYC-miR-494-EZH2 Feed-Forward Circuit Necessary to Maintain Metabolic and Epigenetic Reprogramming of Burkitt Lymphoma Cells. Bialopiotrowicz E, Noyszewska-Kania M, Kachamakova-Trojanowska N, Loboda A, Cybulska M, Grochowska A, Kopczynski M, Mikula M, Prochorec-Sobieszek M, Firczuk M, Graczyk-Jarzynka A, Zagozdzon R, Zabek A, Mlynarz P, Dulak J, Gorniak P, Szydlowski M, Pyziak K, Martyka J, Sroka-Porada A, Jablonska E, Polak A, Kowalczyk P, Szumera-Cieckiewicz A, Chapuy B, Rzymski T, Brzozka K, Juszczynski P. Cancers (Basel). 2020 Mar 3;12(3). pii: cancers12030580. doi: 10.3390/cancers12030580. PubMed |
| Cryptochromes modulate E2F family transcription factors. Chan AB, Huber AL, Lamia KA. Sci Rep. 2020 Mar 5;10(1):4077. doi: 10.1038/s41598-020-61087-y. PubMed |
| Modulation of Transient Receptor Potential Channels 3 and 6 Regulates Osteoclast Function with Impact on Trabecular Bone Loss. Klein S, Mentrup B, Timmen M, Sherwood J, Lindemann O, Fobker M, Kronenberg D, Pap T, Raschke MJ, Stange R. Calcif Tissue Int. 2020 Jun;106(6):655-664. doi: 10.1007/s00223-020-00673-8. Epub 2020 Mar 5. PubMed |
| Fluctuation-Based Super-Resolution Traction Force Microscopy. Stubb A, Laine RF, Miihkinen M, Hamidi H, Guzman C, Henriques R, Jacquemet G, Ivaska J. Nano Lett. 2020 Apr 8;20(4):2230-2245. doi: 10.1021/acs.nanolett.9b04083. Epub 2020 Mar 20. PubMed |
| Mutant ACVR1 Arrests Glial Cell Differentiation to Drive Tumorigenesis in Pediatric Gliomas. Fortin J, Tian R, Zarrabi I, Hill G, Williams E, Sanchez-Duffhues G, Thorikay M, Ramachandran P, Siddaway R, Wong JF, Wu A, Apuzzo LN, Haight J, You-Ten A, Snow BE, Wakeham A, Goldhamer DJ, Schramek D, Bullock AN, Dijke PT, Hawkins C, Mak TW. Cancer Cell. 2020 Mar 16;37(3):308-323.e12. doi: 10.1016/j.ccell.2020.02.002. Epub 2020 Mar 5. PubMed |
Blackjack mutations improve the on-target activities of increased fidelity variants of SpCas9 with 5'G-extended sgRNAs.
Kulcsar PI, Talas A, Toth E, Nyeste A, Ligeti Z, Welker Z, Welker E.
Nat Commun. 2020 Mar 6;11(1):1223. doi: 10.1038/s41467-020-15021-5.
PubMed
Associated Plasmids
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| Interferon inducible GBPs restrict Burkholderia thailandensis motility induced cell-cell fusion. Place DE, Briard B, Samir P, Karki R, Bhattacharya A, Guy CS, Peters JL, Frase S, Vogel P, Neale G, Yamamoto M, Kanneganti TD. PLoS Pathog. 2020 Mar 9;16(3):e1008364. doi: 10.1371/journal.ppat.1008364. eCollection 2020 Mar. PubMed |
| The Peroxisome Proliferator-Activated Receptor alpha- Agonist Gemfibrozil Promotes Defense Against Mycobacterium abscessus Infections. Kim YS, Kim JK, Hanh BTB, Kim SY, Kim HJ, Kim YJ, Jeon SM, Park CR, Oh GT, Park JW, Kim JM, Jang J, Jo EK. Cells. 2020 Mar 6;9(3). pii: cells9030648. doi: 10.3390/cells9030648. PubMed |
| Barrier-to-Autointegration Factor 1 Protects against a Basal cGAS-STING Response. Ma H, Qian W, Bambouskova M, Collins PL, Porter SI, Byrum AK, Zhang R, Artyomov M, Oltz EM, Mosammaparast N, Miner JJ, Diamond MS. mBio. 2020 Mar 10;11(2). pii: mBio.00136-20. doi: 10.1128/mBio.00136-20. PubMed |
| Dishevelled 1-Regulated Superpotent Cancer Stem Cells Mediate Wnt Heterogeneity and Tumor Progression in Hepatocellular Carcinoma. Liao WY, Hsu CC, Chan TS, Yen CJ, Chen WY, Pan HW, Tsai KK. Stem Cell Reports. 2020 Mar 10;14(3):462-477. doi: 10.1016/j.stemcr.2020.02.003. PubMed |
| PIWIL4 Maintains HIV-1 Latency by Enforcing Epigenetically Suppressive Modifications on the 5' Long Terminal Repeat. He Z, Jing S, Yang T, Chen J, Huang F, Zhang W, Peng Z, Liu B, Ma X, Wu L, Pan T, Zhang X, Li L, Cai W, Tang X, Zhang J, Zhang H. J Virol. 2020 May 4;94(10). pii: JVI.01923-19. doi: 10.1128/JVI.01923-19. Print 2020 May 4. PubMed |
| High-Throughput, Temporal and Dose Dependent, Effect of Vitamins and Minerals on Chondrogenesis. Dennis JE, Splawn T, Kean TJ. Front Cell Dev Biol. 2020 Feb 25;8:92. doi: 10.3389/fcell.2020.00092. eCollection 2020. PubMed |
| [A Modified Lentivirus-Based Reporter for Magnetic Separation of Cancer Stem Cells]. Ivanova AE, Kravchenko DS, Chumakov SP. Mol Biol (Mosk). 2020 Jan-Feb;54(1):95-102. doi: 10.31857/S0026898419040049. PubMed |
| Extracellular Redox Regulation of alpha7beta Integrin-Mediated Cell Migration Is Signaled via a Dominant Thiol-Switch. Bergerhausen L, Grosche J, Meissner J, Hecker C, Caliandro MF, Westerhausen C, Kamenac A, Rezaei M, Morgelin M, Poschmann G, Vestweber D, Hanschmann EM, Eble JA. Antioxidants (Basel). 2020 Mar 10;9(3). pii: antiox9030227. doi: 10.3390/antiox9030227. PubMed |
| Genome editing of mutant KRAS through supramolecular polymer-mediated delivery of Cas9 ribonucleoprotein for colorectal cancer therapy. Wan T, Chen Y, Pan Q, Xu X, Kang Y, Gao X, Huang F, Wu C, Ping Y. J Control Release. 2020 Jun 10;322:236-247. doi: 10.1016/j.jconrel.2020.03.015. Epub 2020 Mar 10. PubMed |
| Proteasome inhibitors and Smac mimetics cooperate to induce cell death in diffuse large B-cell lymphoma by stabilizing NOXA and triggering mitochondrial apoptosis. Dietz A, Dalda N, Zielke S, Dittmann J, van Wijk SJL, Vogler M, Fulda S. Int J Cancer. 2020 Sep 1;147(5):1485-1498. doi: 10.1002/ijc.32976. Epub 2020 Apr 8. PubMed |
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Associated Plasmids |
| Aging-regulated anti-apoptotic long non-coding RNA Sarrah augments recovery from acute myocardial infarction. Trembinski DJ, Bink DI, Theodorou K, Sommer J, Fischer A, van Bergen A, Kuo CC, Costa IG, Schurmann C, Leisegang MS, Brandes RP, Alekseeva T, Brill B, Wietelmann A, Johnson CN, Spring-Connell A, Kaulich M, Werfel S, Engelhardt S, Hirt MN, Yorgan K, Eschenhagen T, Kirchhof L, Hofmann P, Jae N, Wittig I, Hamdani N, Bischof C, Krishnan J, Houtkooper RH, Dimmeler S, Boon RA. Nat Commun. 2020 Apr 27;11(1):2039. doi: 10.1038/s41467-020-15995-2. PubMed |
| Decrease in SHP-1 enhances myometrium remodeling via FAK activation leading to labor. Chen HY, Gao LT, Yuan JQ, Zhang YJ, Liu P, Wang G, Ni X, Liu WN, Gao L. Am J Physiol Endocrinol Metab. 2020 Jun 1;318(6):E930-E942. doi: 10.1152/ajpendo.00068.2020. Epub 2020 Apr 28. PubMed |
| GRAF2, WDR44, and MICAL1 mediate Rab8/10/11-dependent export of E-cadherin, MMP14, and CFTR DeltaF508. Lucken-Ardjomande Hasler S, Vallis Y, Pasche M, McMahon HT. J Cell Biol. 2020 May 4;219(5). pii: 151714. doi: 10.1083/jcb.201811014. PubMed |
| Use of Transabdominal Ultrasound for the detection of intra-peritoneal tumor engraftment and growth in mouse xenografts of epithelial ovarian cancer. Chambers LM, Esakov E, Braley C, AlHilli M, Michener C, Reizes O. PLoS One. 2020 Apr 29;15(4):e0228511. doi: 10.1371/journal.pone.0228511. eCollection 2020. PubMed |
| LSD1-mediated enhancer silencing attenuates retinoic acid signalling during pancreatic endocrine cell development. Vinckier NK, Patel NA, Geusz RJ, Wang A, Wang J, Matta I, Harrington AR, Wortham M, Wetton N, Wang J, Jhala US, Rosenfeld MG, Benner CW, Shih HP, Sander M. Nat Commun. 2020 Apr 29;11(1):2082. doi: 10.1038/s41467-020-16017-x. PubMed |
| lncRNA Neat1 Stimulates Osteoclastogenesis Via Sponging miR-7. Zhang Y, Chen XF, Li J, He F, Li X, Guo Y. J Bone Miner Res. 2020 Apr 30. doi: 10.1002/jbmr.4039. PubMed |
| A novel neurodegenerative spectrum disorder in patients with MLKL deficiency. Faergeman SL, Evans H, Attfield KE, Desel C, Kuttikkatte SB, Sommerlund M, Jensen LT, Frokiaer J, Friese MA, Matthews PM, Luchtenborg C, Brugger B, Oturai AB, Dendrou CA, Fugger L. Cell Death Dis. 2020 May 1;11(5):303. doi: 10.1038/s41419-020-2494-0. PubMed |
| FADD and Caspase-8 Regulate Gut Homeostasis and Inflammation by Controlling MLKL- and GSDMD-Mediated Death of Intestinal Epithelial Cells. Schwarzer R, Jiao H, Wachsmuth L, Tresch A, Pasparakis M. Immunity. 2020 Jun 16;52(6):978-993.e6. doi: 10.1016/j.immuni.2020.04.002. Epub 2020 May 1. PubMed |
| Treatment of cancer cells with Lapatinib negatively regulates general translation and induces stress granules formation. Adjibade P, Simoneau B, Ledoux N, Gauthier WN, Nkurunziza M, Khandjian EW, Mazroui R. PLoS One. 2020 May 4;15(5):e0231894. doi: 10.1371/journal.pone.0231894. eCollection 2020. PubMed |
| TRAF3IP3 negatively regulates cytosolic RNA induced anti-viral signaling by promoting TBK1 K48 ubiquitination. Deng M, Tam JW, Wang L, Liang K, Li S, Zhang L, Guo H, Luo X, Zhang Y, Petrucelli A, Davis BK, Conti BJ, June Brickey W, Ko CC, Lei YL, Sun S, Ting JP. Nat Commun. 2020 May 4;11(1):2193. doi: 10.1038/s41467-020-16014-0. PubMed |
| The Robust Restriction of Zika Virus by Type-I Interferon in A549 Cells Varies by Viral Lineage and Is Not Determined by IFITM3. Gobillot TA, Humes D, Sharma A, Kikawa C, Overbaugh J. Viruses. 2020 May 2;12(5). pii: v12050503. doi: 10.3390/v12050503. PubMed |
| Stem cell delivery to kidney via minimally invasive ultrasound-guided renal artery injection in mice. Zaw Thin M, Ogunlade O, Comenge J, Patrick PS, Stuckey DJ, David AL, Lythgoe MF, Beard P, Kalber TL. Sci Rep. 2020 May 5;10(1):7514. doi: 10.1038/s41598-020-64417-2. PubMed |
| Expression and function of voltage gated proton channels (Hv1) in MDA-MB-231 cells. Bare DJ, Cherny VV, DeCoursey TE, Abukhdeir AM, Morgan D. PLoS One. 2020 May 6;15(5):e0227522. doi: 10.1371/journal.pone.0227522. eCollection 2020. PubMed |
| An Alternative Splicing of Tupaia STING Modulated Anti-RNA Virus Responses by Targeting MDA5-LGP2 and IRF3. Xu L, Yu D, Peng L, Wu Y, Fan Y, Gu T, Yao YL, Zhong J, Chen X, Yao YG. J Immunol. 2020 Jun 15;204(12):3191-3204. doi: 10.4049/jimmunol.1901320. Epub 2020 May 6. PubMed |
Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I.
Yamamoto K, Venida A, Yano J, Biancur DE, Kakiuchi M, Gupta S, Sohn ASW, Mukhopadhyay S, Lin EY, Parker SJ, Banh RS, Paulo JA, Wen KW, Debnath J, Kim GE, Mancias JD, Fearon DT, Perera RM, Kimmelman AC.
Nature. 2020 May;581(7806):100-105. doi: 10.1038/s41586-020-2229-5. Epub 2020 Apr 22.
PubMed
Associated Plasmids |
| Porcine DNAJB6 promotes PCV2 replication via enhancing the formation of autophagy in host cells. Han C, Du Q, Zhu L, Chen N, Luo L, Chen Q, Yin J, Wu X, Tong D, Huang Y. Vet Res. 2020 May 7;51(1):61. doi: 10.1186/s13567-020-00783-z. PubMed |
| Efficient Generation and Correction of Mutations in Human iPS Cells Utilizing mRNAs of CRISPR Base Editors and Prime Editors. Surun D, Schneider A, Mircetic J, Neumann K, Lansing F, Paszkowski-Rogacz M, Hanchen V, Lee-Kirsch MA, Buchholz F. Genes (Basel). 2020 May 6;11(5). pii: genes11050511. doi: 10.3390/genes11050511. PubMed |
| Intramitochondrial proteostasis is directly coupled to alpha-synuclein and amyloid beta1-42 pathologies. Lautenschlager J, Wagner-Valladolid S, Stephens AD, Fernandez-Villegas A, Hockings C, Mishra A, Manton JD, Fantham MJ, Lu M, Rees EJ, Kaminski CF, Kaminski Schierle GS. J Biol Chem. 2020 Jul 24;295(30):10138-10152. doi: 10.1074/jbc.RA119.011650. Epub 2020 May 8. PubMed |
| Biochemical characteristics of the chondrocyte-enriched SNORC protein and its transcriptional regulation by SOX9. Jaiswal PK, Aljebali L, Gaumond MH, Oh CD, Yasuda H, Moffatt P. Sci Rep. 2020 May 8;10(1):7790. doi: 10.1038/s41598-020-64640-x. PubMed |
| Targeted Degradation of SLC Transporters Reveals Amenability of Multi-Pass Transmembrane Proteins to Ligand-Induced Proteolysis. Bensimon A, Pizzagalli MD, Kartnig F, Dvorak V, Essletzbichler P, Winter GE, Superti-Furga G. Cell Chem Biol. 2020 Jun 18;27(6):728-739.e9. doi: 10.1016/j.chembiol.2020.04.003. Epub 2020 May 7. PubMed |
| NFI transcription factors provide chromatin access to maintain stem cell identity while preventing unintended lineage fate choices. Adam RC, Yang H, Ge Y, Infarinato NR, Gur-Cohen S, Miao Y, Wang P, Zhao Y, Lu CP, Kim JE, Ko JY, Paik SS, Gronostajski RM, Kim J, Krueger JG, Zheng D, Fuchs E. Nat Cell Biol. 2020 Jun;22(6):640-650. doi: 10.1038/s41556-020-0513-0. Epub 2020 May 11. PubMed |
| Mucus blocks probiotics but increases penetration of motile pathogens and induces TNF-alpha and IL-8 secretion. Sharma A, Raman V, Lee J, Forbes NS. Biotechnol Bioeng. 2020 Aug;117(8):2540-2555. doi: 10.1002/bit.27383. Epub 2020 Jun 2. PubMed |
| Mitochondrial-related effects of pentabromophenol, tetrabromobisphenol A, and triphenyl phosphate on murine BV-2 microglia cells. Bowen C, Childers G, Perry C, Martin N, McPherson CA, Lauten T, Santos J, Harry GJ. Chemosphere. 2020 Sep;255:126919. doi: 10.1016/j.chemosphere.2020.126919. Epub 2020 Apr 30. PubMed |
| Tob2 phosphorylation regulates global mRNA turnover to reshape transcriptome and impact cell proliferation. Chen CA, Strouz K, Huang KL, Shyu AB. RNA. 2020 Sep;26(9):1143-1159. doi: 10.1261/rna.073528.119. Epub 2020 May 13. PubMed |
| The mRNA Cap 2'-O-Methyltransferase CMTR1 Regulates the Expression of Certain Interferon-Stimulated Genes. Williams GD, Gokhale NS, Snider DL, Horner SM. mSphere. 2020 May 13;5(3). pii: 5/3/e00202-20. doi: 10.1128/mSphere.00202-20. PubMed |
| Patient fibroblast circadian rhythms predict lithium sensitivity in bipolar disorder. Sanghani HR, Jagannath A, Humberstone T, Ebrahimjee F, Thomas JM, Churchill GC, Cipriani A, Attenburrow MJ, Perestenko OV, Cowley SA, Cader MZ, Peirson SN, Harrison PJ, Foster RG, Goodwin GM, Vasudevan SR. Mol Psychiatry. 2020 May 13. pii: 10.1038/s41380-020-0769-6. doi: 10.1038/s41380-020-0769-6. PubMed |
High-affinity mutant Interleukin-13 targeted CAR T cells enhance delivery of clickable biodegradable fluorescent nanoparticles to glioblastoma.
Kim GB, Aragon-Sanabria V, Randolph L, Jiang H, Reynolds JA, Webb BS, Madhankumar A, Lian X, Connor JR, Yang J, Dong C.
Bioact Mater. 2020 May 7;5(3):624-635. doi: 10.1016/j.bioactmat.2020.04.011. eCollection 2020 Sep.
PubMed
Associated Plasmids |
| Schwann cell reprogramming into repair cells increases miRNA-21 expression in exosomes promoting axonal growth. Lopez-Leal R, Diaz-Viraque F, Catalan RJ, Saquel C, Enright A, Iraola G, Court FA. J Cell Sci. 2020 Jun 15;133(12). pii: jcs.239004. doi: 10.1242/jcs.239004. PubMed |
| Laminin-511 and alpha6 integrins regulate the expression of CXCR4 to promote endothelial morphogenesis. Xu H, Pumiglia K, LaFlamme SE. J Cell Sci. 2020 Jun 11;133(11). pii: jcs.246595. doi: 10.1242/jcs.246595. PubMed |
| LINC00261 Is Differentially Expressed in Pancreatic Cancer Subtypes and Regulates a Pro-Epithelial Cell Identity. Dorn A, Glass M, Neu CT, Heydel B, Huttelmaier S, Gutschner T, Haemmerle M. Cancers (Basel). 2020 May 13;12(5). pii: cancers12051227. doi: 10.3390/cancers12051227. PubMed |
| Molecular profiling reveals a hypoxia signature in breast implant-associated anaplastic large cell lymphoma. Oishi N, Hundal T, Phillips JL, Dasari S, Hu G, Viswanatha DS, He R, Mai M, Jacobs HK, Ahmed NH, Syrbu SI, Salama Y, Chapman JR, Vega F, Sidhu J, Bennani NN, Epstein AL, Medeiros LJ, Clemens MW, Miranda RN, Feldman AL. Haematologica. 2020 May 15. pii: haematol.2019.245860. doi: 10.3324/haematol.2019.245860. PubMed |
| Procedures for Culturing and Genetically Manipulating Murine Hippocampal Postnatal Neurons. Moutin E, Hemonnot AL, Seube V, Linck N, Rassendren F, Perroy J, Compan V. Front Synaptic Neurosci. 2020 Apr 30;12:19. doi: 10.3389/fnsyn.2020.00019. eCollection 2020. PubMed |
| ZKSCAN3 counteracts cellular senescence by stabilizing heterochromatin. Hu H, Ji Q, Song M, Ren J, Liu Z, Wang Z, Liu X, Yan K, Hu J, Jing Y, Wang S, Zhang W, Liu GH, Qu J. Nucleic Acids Res. 2020 Jun 19;48(11):6001-6018. doi: 10.1093/nar/gkaa425. PubMed |
| Selective role of Nck1 in atherogenic inflammation and plaque formation. Alfaidi M, Acosta CH, Wang D, Traylor JG, Orr AW. J Clin Invest. 2020 Aug 3;130(8):4331-4347. doi: 10.1172/JCI135552. PubMed |
| Enterovirus 71 induces neural cell apoptosis and autophagy through promoting ACOX1 downregulation and ROS generation. You L, Chen J, Liu W, Xiang Q, Luo Z, Wang W, Xu W, Wu K, Zhang Q, Liu Y, Wu J. Virulence. 2020 Dec;11(1):537-553. doi: 10.1080/21505594.2020.1766790. PubMed |
| HLTF Promotes Fork Reversal, Limiting Replication Stress Resistance and Preventing Multiple Mechanisms of Unrestrained DNA Synthesis. Bai G, Kermi C, Stoy H, Schiltz CJ, Bacal J, Zaino AM, Hadden MK, Eichman BF, Lopes M, Cimprich KA. Mol Cell. 2020 Jun 18;78(6):1237-1251.e7. doi: 10.1016/j.molcel.2020.04.031. Epub 2020 May 21. PubMed |
| Wnt/beta-catenin signaling contributes to prostate cancer heterogeneity through reciprocal suppression of H3K27 trimethylation. Wang F, Zhu Y, Wang F, Wang Y, Dong BJ, Wang N, Gao WQ. Biochem Biophys Res Commun. 2020 Jun 18;527(1):242-249. doi: 10.1016/j.bbrc.2020.04.112. Epub 2020 May 4. PubMed |
| Nucleoporin 153 links nuclear pore complex to chromatin architecture by mediating CTCF and cohesin binding. Kadota S, Ou J, Shi Y, Lee JT, Sun J, Yildirim E. Nat Commun. 2020 May 25;11(1):2606. doi: 10.1038/s41467-020-16394-3. PubMed |
| Ecto-NTPDase CD39 is a negative checkpoint that inhibits follicular helper cell generation. Cao W, Fang F, Gould T, Li X, Kim C, Gustafson C, Lambert S, Weyand CM, Goronzy JJ. J Clin Invest. 2020 Jul 1;130(7):3422-3436. doi: 10.1172/JCI132417. PubMed |
| DNA damage invokes mitophagy through a pathway involving Spata18. Dan X, Babbar M, Moore A, Wechter N, Tian J, Mohanty JG, Croteau DL, Bohr VA. Nucleic Acids Res. 2020 Jul 9;48(12):6611-6623. doi: 10.1093/nar/gkaa393. PubMed |
| Lentivirally administered glial cell line-derived neurotrophic factor promotes post-ischemic neurological recovery, brain remodeling and contralesional pyramidal tract plasticity by regulating axonal growth inhibitors and guidance proteins. Beker M, Caglayan AB, Beker MC, Altunay S, Karacay R, Dalay A, Altintas MO, Kose GT, Hermann DM, Kilic E. Exp Neurol. 2020 May 23;331:113364. doi: 10.1016/j.expneurol.2020.113364. PubMed |
| An Integrated Genomic Strategy to Identify CHRNB4 as a Diagnostic/Prognostic Biomarker for Targeted Therapy in Head and Neck Cancer. Chuang YH, Lee CH, Lin CY, Liu CL, Huang SH, Lee JY, Chiu YY, Lee JC, Yang JM. Cancers (Basel). 2020 May 22;12(5). pii: cancers12051324. doi: 10.3390/cancers12051324. PubMed |
| SIX2 Regulates Human beta Cell Differentiation from Stem Cells and Functional Maturation In Vitro. Velazco-Cruz L, Goedegebuure MM, Maxwell KG, Augsornworawat P, Hogrebe NJ, Millman JR. Cell Rep. 2020 May 26;31(8):107687. doi: 10.1016/j.celrep.2020.107687. PubMed |
| Increased expression of miR142 and miR155 in glial and immune cells after traumatic brain injury may contribute to neuroinflammation via astrocyte activation. Korotkov A, Puhakka N, Gupta SD, Vuokila N, Broekaart DWM, Anink JJ, Heiskanen M, Karttunen J, van Scheppingen J, Huitinga I, Mills JD, van Vliet EA, Pitkanen A, Aronica E. Brain Pathol. 2020 May 27. doi: 10.1111/bpa.12865. PubMed |
| MESH1 is a cytosolic NADPH phosphatase that regulates ferroptosis. Ding CC, Rose J, Sun T, Wu J, Chen PH, Lin CC, Yang WH, Chen KY, Lee H, Xu E, Tian S, Akinwuntan J, Zhao J, Guan Z, Zhou P, Chi JT. Nat Metab. 2020 Mar;2(3):270-277. doi: 10.1038/s42255-020-0181-1. Epub 2020 Mar 9. PubMed |
| STAG1 vulnerabilities for exploiting cohesin synthetic lethality in STAG2-deficient cancers. van der Lelij P, Newman JA, Lieb S, Jude J, Katis V, Hoffmann T, Hinterndorfer M, Bader G, Kraut N, Pearson MA, Peters JM, Zuber J, Gileadi O, Petronczki M. Life Sci Alliance. 2020 May 28;3(7). pii: 3/7/e202000725. doi: 10.26508/lsa.202000725. Print 2020 Jul. PubMed |
| Nck1, But Not Nck2, Mediates Disturbed Flow-Induced p21-Activated Kinase Activation and Endothelial Permeability. Alfaidi M, Bhattarai U, Orr AW. J Am Heart Assoc. 2020 Jun 2;9(11):e016099. doi: 10.1161/JAHA.120.016099. Epub 2020 May 29. PubMed |
| Isolation of Human Small Extracellular Vesicles and Tracking of their Uptake by Retinal Pigment Epithelial Cells In Vitro. Marcu IC, Eberhard N, Yerly A, Balmer V, Hemphill A, Mogel H, Gaschen V, Stoffel MH, Bluteau J. Int J Mol Sci. 2020 May 27;21(11). pii: ijms21113799. doi: 10.3390/ijms21113799. PubMed |
| Establishment of stable Vero cell lines expressing TMPRSS2 and MSPL: A useful tool for propagating porcine epidemic diarrhea virus in the absence of exogenous trypsin. Wang X, Qiao X, Sui L, Zhao H, Li F, Tang YD, Shi W, Guo Y, Jiang Y, Wang L, Zhou H, Tang L, Xu Y, Li Y. Virulence. 2020 Dec;11(1):669-685. doi: 10.1080/21505594.2020.1770491. PubMed |
| miR-486 is involved in the pathogenesis of acute myeloid leukemia by regulating JAK-STAT signaling. Sha C, Jia G, Jingjing Z, Yapeng H, Zhi L, Guanghui X. Naunyn Schmiedebergs Arch Pharmacol. 2020 May 29. pii: 10.1007/s00210-020-01892-4. doi: 10.1007/s00210-020-01892-4. PubMed |
| Chemical modulation of circadian rhythms and assessment of cellular behavior via indirubin and derivatives. Lin HH, Robertson KL, Lellupitiyage Don SS, Taylor SR, Farkas ME. Methods Enzymol. 2020;639:115-140. doi: 10.1016/bs.mie.2020.04.011. Epub 2020 Apr 30. PubMed |
| Frequent upregulation of G9a promotes RelB-dependent proliferation and survival in multiple myeloma. Zhang XY, Rajagopalan D, Chung TH, Hooi L, Toh TB, Tian JS, Rashid MBMA, Sahib NRBM, Gu M, Lim JJ, Wang W, Chng WJ, Jha S, Chow EK. Exp Hematol Oncol. 2020 May 22;9:8. doi: 10.1186/s40164-020-00164-4. eCollection 2020. PubMed |
| Protrudin-mediated ER-endosome contact sites promote MT1-MMP exocytosis and cell invasion. Pedersen NM, Wenzel EM, Wang L, Antoine S, Chavrier P, Stenmark H, Raiborg C. J Cell Biol. 2020 Aug 3;219(8). pii: 151827. doi: 10.1083/jcb.202003063. PubMed |
| CAMK2A supported tumor initiating cells of lung adenocarcinoma by upregulating SOX2 through EZH2 phosphorylation. Wang SQ, Liu J, Qin J, Zhu Y, Tin VP, Yam JWP, Wong MP, Xiao ZJ. Cell Death Dis. 2020 Jun 1;11(6):410. doi: 10.1038/s41419-020-2553-6. PubMed |
| Targeted Perturb-seq enables genome-scale genetic screens in single cells. Schraivogel D, Gschwind AR, Milbank JH, Leonce DR, Jakob P, Mathur L, Korbel JO, Merten CA, Velten L, Steinmetz LM. Nat Methods. 2020 Jun;17(6):629-635. doi: 10.1038/s41592-020-0837-5. Epub 2020 Jun 1. PubMed |
Base editors for simultaneous introduction of C-to-T and A-to-G mutations.
Sakata RC, Ishiguro S, Mori H, Tanaka M, Tatsuno K, Ueda H, Yamamoto S, Seki M, Masuyama N, Nishida K, Nishimasu H, Arakawa K, Kondo A, Nureki O, Tomita M, Aburatani H, Yachie N.
Nat Biotechnol. 2020 Jun 1. pii: 10.1038/s41587-020-0509-0. doi: 10.1038/s41587-020-0509-0.
PubMed
Associated Plasmids |
| Identification of a potent and selective covalent Pin1 inhibitor. Pinch BJ, Doctor ZM, Nabet B, Browne CM, Seo HS, Mohardt ML, Kozono S, Lian X, Manz TD, Chun Y, Kibe S, Zaidman D, Daitchman D, Yeoh ZC, Vangos NE, Geffken EA, Tan L, Ficarro SB, London N, Marto JA, Buratowski S, Dhe-Paganon S, Zhou XZ, Lu KP, Gray NS. Nat Chem Biol. 2020 Sep;16(9):979-987. doi: 10.1038/s41589-020-0550-9. Epub 2020 Jun 1. PubMed |
| Harnessing stemness and PD-L1 expression by AT-rich interaction domain-containing protein 3B in colorectal cancer. Liao TT, Lin CC, Jiang JK, Yang SH, Teng HW, Yang MH. Theranostics. 2020 May 15;10(14):6095-6112. doi: 10.7150/thno.44147. eCollection 2020. PubMed |
| ABL Genomic Editing Sufficiently Abolishes Oncogenesis of Human Chronic Myeloid Leukemia Cells In Vitro and In Vivo. Chen SH, Hsieh YY, Tzeng HE, Lin CY, Hsu KW, Chiang YS, Lin SM, Su MJ, Hsieh WS, Lee CH. Cancers (Basel). 2020 May 29;12(6). pii: cancers12061399. doi: 10.3390/cancers12061399. PubMed |
| A potent CBP/p300-Snail interaction inhibitor suppresses tumor growth and metastasis in wild-type p53-expressing cancer. Li HM, Bi YR, Li Y, Fu R, Lv WC, Jiang N, Xu Y, Ren BX, Chen YD, Xie H, Wang S, Lu T, Wu ZQ. Sci Adv. 2020 Apr 22;6(17):eaaw8500. doi: 10.1126/sciadv.aaw8500. eCollection 2020 Apr. PubMed |
| CD31 (PECAM-1) Serves as the Endothelial Cell-Specific Receptor of Clostridium perfringens beta-Toxin. Bruggisser J, Tarek B, Wyder M, Muller P, von Ballmoos C, Witz G, Enzmann G, Deutsch U, Engelhardt B, Posthaus H. Cell Host Microbe. 2020 Jul 8;28(1):69-78.e6. doi: 10.1016/j.chom.2020.05.003. Epub 2020 Jun 3. PubMed |
| Proximal Biotinylation-Based Combinatory Approach for Isolating Integral Plasma Membrane Proteins. Akdag M, Yunt ZS, Kamacioglu A, Qureshi MH, Akarlar BA, Ozlu N. J Proteome Res. 2020 Aug 7;19(8):3583-3592. doi: 10.1021/acs.jproteome.0c00113. Epub 2020 Jun 15. PubMed |
| MYC functions as a switch for natural killer cell-mediated immune surveillance of lymphoid malignancies. Swaminathan S, Hansen AS, Heftdal LD, Dhanasekaran R, Deutzmann A, Fernandez WDM, Liefwalker DF, Horton C, Mosley A, Liebersbach M, Maecker HT, Felsher DW. Nat Commun. 2020 Jun 5;11(1):2860. doi: 10.1038/s41467-020-16447-7. PubMed |
| SIRT7 antagonizes human stem cell aging as a heterochromatin stabilizer. Bi S, Liu Z, Wu Z, Wang Z, Liu X, Wang S, Ren J, Yao Y, Zhang W, Song M, Liu GH, Qu J. Protein Cell. 2020 Jul;11(7):483-504. doi: 10.1007/s13238-020-00728-4. Epub 2020 Jun 6. PubMed |
Direct-seq: programmed gRNA scaffold for streamlined scRNA-seq in CRISPR screen.
Song Q, Ni K, Liu M, Li Y, Wang L, Wang Y, Liu Y, Yu Z, Qi Y, Lu Z, Ma L.
Genome Biol. 2020 Jun 8;21(1):136. doi: 10.1186/s13059-020-02044-w.
PubMed
Associated Plasmids |
| Modulation of dopamine D1 receptors via histamine H3 receptors is a novel therapeutic target for Huntington's disease. Moreno-Delgado D, Puigdellivol M, Moreno E, Rodriguez-Ruiz M, Botta J, Gasperini P, Chiarlone A, Howell LA, Scarselli M, Casado V, Cortes A, Ferre S, Guzman M, Lluis C, Alberch J, Canela EI, Gines S, McCormick PJ. Elife. 2020 Jun 9;9. pii: 51093. doi: 10.7554/eLife.51093. PubMed |
| Selective Translation of Cell Fate Regulators Mediates Tolerance to Broad Oncogenic Stress. Cai EY, Kufeld MN, Schuster S, Arora S, Larkin M, Germanos AA, Hsieh AC, Beronja S. Cell Stem Cell. 2020 Aug 6;27(2):270-283.e7. doi: 10.1016/j.stem.2020.05.007. Epub 2020 Jun 8. PubMed |
| Endogenous DNA 3' Blocks Are Vulnerabilities for BRCA1 and BRCA2 Deficiency and Are Reversed by the APE2 Nuclease. Alvarez-Quilon A, Wojtaszek JL, Mathieu MC, Patel T, Appel CD, Hustedt N, Rossi SE, Wallace BD, Setiaputra D, Adam S, Ohashi Y, Melo H, Cho T, Gervais C, Munoz IM, Grazzini E, Young JTF, Rouse J, Zinda M, Williams RS, Durocher D. Mol Cell. 2020 Jun 18;78(6):1152-1165.e8. doi: 10.1016/j.molcel.2020.05.021. Epub 2020 Jun 8. PubMed |
Massively parallel Cas13 screens reveal principles for guide RNA design.
Wessels HH, Mendez-Mancilla A, Guo X, Legut M, Daniloski Z, Sanjana NE.
Nat Biotechnol. 2020 Jun;38(6):722-727. doi: 10.1038/s41587-020-0456-9. Epub 2020 Mar 16.
PubMed
Associated Plasmids
|
| Stem Cell Determinant SOX9 Promotes Lineage Plasticity and Progression in Basal-like Breast Cancer. Christin JR, Wang C, Chung CY, Liu Y, Dravis C, Tang W, Oktay MH, Wahl GM, Guo W. Cell Rep. 2020 Jun 9;31(10):107742. doi: 10.1016/j.celrep.2020.107742. PubMed |
| A Novel Function of Sphingosine Kinase 2 in the Metabolism of Sphinga-4,14-Diene Lipids. Couttas TA, Rustam YH, Song H, Qi Y, Teo JD, Chen J, Reid GE, Don AS. Metabolites. 2020 Jun 8;10(6). pii: metabo10060236. doi: 10.3390/metabo10060236. PubMed |
| Viral Transduction of DRG Neurons. Sasaki Y. Methods Mol Biol. 2020;2143:55-62. doi: 10.1007/978-1-0716-0585-1_5. PubMed |
| Effects of Inorganic Arsenic on Human Prostate Stem-Progenitor Cell Transformation, Autophagic Flux Blockade, and NRF2 Pathway Activation. Xie L, Hu WY, Hu DP, Shi G, Li Y, Yang J, Prins GS. Environ Health Perspect. 2020 Jun;128(6):67008. doi: 10.1289/EHP6471. Epub 2020 Jun 11. PubMed |
| Loss of STAT6 leads to anchorage-independent growth and trastuzumab resistance in HER2+ breast cancer cells. DiScala M, Najor MS, Yung T, Morgan D, Abukhdeir AM, Cobleigh MA. PLoS One. 2020 Jun 11;15(6):e0234146. doi: 10.1371/journal.pone.0234146. eCollection 2020. PubMed |
| Targeting FTO Suppresses Cancer Stem Cell Maintenance and Immune Evasion. Su R, Dong L, Li Y, Gao M, Han L, Wunderlich M, Deng X, Li H, Huang Y, Gao L, Li C, Zhao Z, Robinson S, Tan B, Qing Y, Qin X, Prince E, Xie J, Qin H, Li W, Shen C, Sun J, Kulkarni P, Weng H, Huang H, Chen Z, Zhang B, Wu X, Olsen MJ, Muschen M, Marcucci G, Salgia R, Li L, Fathi AT, Li Z, Mulloy JC, Wei M, Horne D, Chen J. Cancer Cell. 2020 Jul 13;38(1):79-96.e11. doi: 10.1016/j.ccell.2020.04.017. Epub 2020 Jun 11. PubMed |
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Structural Insights into the SPRED1-Neurofibromin-KRAS Complex and Disruption of SPRED1-Neurofibromin Interaction by Oncogenic EGFR.
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| Elevating Insulin Signaling Using a Constitutively Active Insulin Receptor Increases Glucose Metabolism and Expression of GLUT3 in Hippocampal Neurons. Frazier HN, Ghoweri AO, Anderson KL, Lin RL, Popa GJ, Mendenhall MD, Reagan LP, Craven RJ, Thibault O. Front Neurosci. 2020 Jul 7;14:668. doi: 10.3389/fnins.2020.00668. eCollection 2020. PubMed |
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| Multi-modal imaging probe for assessing the efficiency of stem cell delivery to orthotopic breast tumours. Zaw Thin M, Allan H, Bofinger R, Kostelec TD, Guillaume S, Connell JJ, Patrick PS, Hailes HC, Tabor AB, Lythgoe MF, Stuckey DJ, Kalber TL. Nanoscale. 2020 Aug 13;12(31):16570-16585. doi: 10.1039/d0nr03237a. PubMed |
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| Saffron Crudes and Compounds Restrict MACC1-Dependent Cell Proliferation and Migration of Colorectal Cancer Cells. Gullu N, Kobelt D, Brim H, Rahman S, Timm L, Smith J, Soleimani A, Di Marco S, Bisti S, Ashktorab H, Stein U. Cells. 2020 Aug 3;9(8). pii: cells9081829. doi: 10.3390/cells9081829. PubMed |
| The oncofetal RNA-binding protein IGF2BP1 is a druggable, post-transcriptional super-enhancer of E2F-driven gene expression in cancer. Muller S, Bley N, Busch B, Glass M, Lederer M, Misiak C, Fuchs T, Wedler A, Haase J, Bertoldo JB, Michl P, Huttelmaier S. Nucleic Acids Res. 2020 Sep 4;48(15):8576-8590. doi: 10.1093/nar/gkaa653. PubMed |
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A multiplexed bioluminescent reporter for sensitive and non-invasive tracking of DNA double strand break repair dynamics in vitro and in vivo.
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Phase Separation of a PKA Regulatory Subunit Controls cAMP Compartmentation and Oncogenic Signaling.
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| Altered 3D chromatin structure permits inversional recombination at the IgH locus. Qiu X, Ma F, Zhao M, Cao Y, Shipp L, Liu A, Dutta A, Singh A, Braikia FZ, De S, Wood WH 3rd, Becker KG, Zhou W, Ji H, Zhao K, Atchison ML, Sen R. Sci Adv. 2020 Aug 14;6(33):eaaz8850. doi: 10.1126/sciadv.aaz8850. eCollection 2020 Aug. PubMed |
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| Phosphorylation of Syntaxin-1a by casein kinase 2alpha regulates pre-synaptic vesicle exocytosis from the reserve pool. Shi VH, Craig TJ, Bishop P, Nakamura Y, Rocca D, Wilkinson KA, Henley JM. J Neurochem. 2021 Mar;156(5):614-623. doi: 10.1111/jnc.15161. Epub 2020 Sep 6. PubMed |
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| Quantifying the Brain Metastatic Tumor Micro-Environment using an Organ-On-A Chip 3D Model, Machine Learning, and Confocal Tomography. Oliver CR, Westerhof TM, Castro MG, Merajver SD. J Vis Exp. 2020 Aug 16;(162). doi: 10.3791/61654. PubMed |
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| miR-183/96/182 cluster is an important morphogenetic factor targeting PAX6 expression in differentiating human retinal organoids. Peskova L, Jurcikova D, Vanova T, Krivanek J, Capandova M, Sramkova Z, Sebestikova J, Kolouskova M, Kotasova H, Streit L, Barta T. Stem Cells. 2020 Sep 1. doi: 10.1002/stem.3272. PubMed |
| Complex roles of the actin-binding protein Girdin/GIV in DNA damage-induced apoptosis of cancer cells. Chen C, Enomoto A, Weng L, Taki T, Shiraki Y, Mii S, Ichihara R, Kanda M, Koike M, Kodera Y, Takahashi M. Cancer Sci. 2020 Nov;111(11):4303-4317. doi: 10.1111/cas.14637. Epub 2020 Sep 19. PubMed |
| An Excitable Ras/PI3K/ERK Signaling Network Controls Migration and Oncogenic Transformation in Epithelial Cells. Zhan H, Bhattacharya S, Cai H, Iglesias PA, Huang CH, Devreotes PN. Dev Cell. 2020 Sep 14;54(5):608-623.e5. doi: 10.1016/j.devcel.2020.08.001. Epub 2020 Sep 1. PubMed |
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Background-suppressed live visualization of genomic loci with an improved CRISPR system based on a split fluorophore.
Chaudhary N, Nho SH, Cho H, Gantumur N, Ra JS, Myung K, Kim H.
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An alpaca nanobody neutralizes SARS-CoV-2 by blocking receptor interaction.
Hanke L, Vidakovics Perez L, Sheward DJ, Das H, Schulte T, Moliner-Morro A, Corcoran M, Achour A, Karlsson Hedestam GB, Hallberg BM, Murrell B, McInerney GM.
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| Endogenous retroviruses drive species-specific germline transcriptomes in mammals. Sakashita A, Maezawa S, Takahashi K, Alavattam KG, Yukawa M, Hu YC, Kojima S, Parrish NF, Barski A, Pavlicev M, Namekawa SH. Nat Struct Mol Biol. 2020 Oct;27(10):967-977. doi: 10.1038/s41594-020-0487-4. Epub 2020 Sep 7. PubMed |
| Effects of IGF-1 on Proliferation, Angiogenesis, Tumor Stem Cell Populations and Activation of AKT and Hedgehog Pathways in Oral Squamous Cell Carcinoma. Ferreira Mendes JM, de Faro Valverde L, Torres Andion Vidal M, Paredes BD, Coelho P, Allahdadi KJ, Coletta RD, Souza BSF, Rocha CAG. Int J Mol Sci. 2020 Sep 5;21(18). pii: ijms21186487. doi: 10.3390/ijms21186487. PubMed |
| YAP-Mediated Repression of HRK Regulates Tumor Growth, Therapy Response, and Survival Under Tumor Environmental Stress in Neuroblastoma. Shim J, Lee JY, Jonus HC, Arnold A, Schnepp RW, Janssen KM, Maximov V, Goldsmith KC. Cancer Res. 2020 Nov 1;80(21):4741-4753. doi: 10.1158/0008-5472.CAN-20-0025. Epub 2020 Sep 8. PubMed |
A molecular sensor to quantify the localization of proteins, DNA and nanoparticles in cells.
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| CCAAT/Enhancer-Binding Protein Delta (C/EBPdelta): A Previously Unrecognized Tumor Suppressor that Limits the Oncogenic Potential of Pancreatic Ductal Adenocarcinoma Cells. Hartl L, Duitman J, Aberson HL, Chen K, Dijk F, Roelofs JJTH, Dings MPG, Hooijer GKJ, Hernanda PY, Pan Q, Busch OR, Besselink MGH, Boerman T, Peppelenbosch MP, Bijlsma MF, Spek CA. Cancers (Basel). 2020 Sep 7;12(9). pii: cancers12092546. doi: 10.3390/cancers12092546. PubMed |
| In Vivo Reporter Assays Uncover Changes in Enhancer Activity Caused by Type 2 Diabetes-Associated Single Nucleotide Polymorphisms. Eufrasio A, Perrod C, Ferreira FJ, Duque M, Galhardo M, Bessa J. Diabetes. 2020 Dec;69(12):2794-2805. doi: 10.2337/db19-1049. Epub 2020 Sep 10. PubMed |
| Molecular characterization of HLA class II binding to the LAG-3 T cell co-inhibitory receptor. MacLachlan BJ, Mason GH, Greenshields-Watson A, Triebel F, Gallimore A, Cole DK, Godkin A. Eur J Immunol. 2021 Feb;51(2):331-341. doi: 10.1002/eji.202048753. Epub 2020 Oct 9. PubMed |
| Generation of Inducible CRISPRi and CRISPRa Human Stromal/Stem Cell Lines for Controlled Target Gene Transcription during Lineage Differentiation. Chen L, Shi K, Qiu W, Aagaard L, Kassem M. Stem Cells Int. 2020 Aug 19;2020:8857344. doi: 10.1155/2020/8857344. eCollection 2020. PubMed |
| Leukemia Inhibitory Factor (LIF) Overexpression Increases the Angiogenic Potential of Bone Marrow Mesenchymal Stem/Stromal Cells. Santos GC, Silva DN, Fortuna V, Silveira BM, Orge ID, de Santana TA, Sampaio GL, Paredes BD, Ribeiro-Dos-Santos R, Soares MBP. Front Cell Dev Biol. 2020 Aug 14;8:778. doi: 10.3389/fcell.2020.00778. eCollection 2020. PubMed |
| Primate-restricted KRAB zinc finger proteins and target retrotransposons control gene expression in human neurons. Turelli P, Playfoot C, Grun D, Raclot C, Pontis J, Coudray A, Thorball C, Duc J, Pankevich EV, Deplancke B, Busskamp V, Trono D. Sci Adv. 2020 Aug 28;6(35):eaba3200. doi: 10.1126/sciadv.aba3200. eCollection 2020 Aug. PubMed |
| Protective role of histone deacetylase 4 from ultraviolet radiation-induced DNA lesions. Li S, Zhou M, Ze K, Sun X, Zhao C, Li Z, Lu H, Jiao Y, Wang T, Li S, Hua L, Cai H, Li X. Mol Carcinog. 2020 Nov;59(11):1292-1301. doi: 10.1002/mc.23257. Epub 2020 Sep 13. PubMed |
| Phosphoinositide-dependent Kinase-1 (PDPK1) regulates serum/glucocorticoid-regulated Kinase 3 (SGK3) for prostate cancer cell survival. Nalairndran G, Hassan Abdul Razack A, Mai CW, Fei-Lei Chung F, Chan KK, Hii LW, Lim WM, Chung I, Leong CO. J Cell Mol Med. 2020 Oct;24(20):12188-12198. doi: 10.1111/jcmm.15876. Epub 2020 Sep 14. PubMed |
| LncRNA DSCAM-AS1 interacts with YBX1 to promote cancer progression by forming a positive feedback loop that activates FOXA1 transcription network. Zhang Y, Huang YX, Wang DL, Yang B, Yan HY, Lin LH, Li Y, Chen J, Xie LM, Huang YS, Liao JY, Hu KS, He JH, Saw PE, Xu X, Yin D. Theranostics. 2020 Aug 29;10(23):10823-10837. doi: 10.7150/thno.47830. eCollection 2020. PubMed |
| Mutational resilience of antiviral restriction favors primate TRIM5alpha in host-virus evolutionary arms races. Tenthorey JL, Young C, Sodeinde A, Emerman M, Malik HS. Elife. 2020 Sep 15;9. pii: 59988. doi: 10.7554/eLife.59988. PubMed |
| Altered Secretome and ROS Production in Olfactory Mucosa Stem Cells Derived from Friedreich's Ataxia Patients. Perez-Luz S, Loria F, Katsu-Jimenez Y, Oberdoerfer D, Yang OL, Lim F, Munoz-Blanco JL, Diaz-Nido J. Int J Mol Sci. 2020 Sep 11;21(18). pii: ijms21186662. doi: 10.3390/ijms21186662. PubMed |
| Integration of Multiple Platforms for the Analysis of Multifluorescent Marking Technology Applied to Pediatric GBM and DIPG. Pericoli G, Petrini S, Giorda E, Ferretti R, Ajmone-Cat MA, Court W, Conti LA, De Simone R, Bencivenga P, Palma A, Di Giannatale A, Jones C, Carai A, Mastronuzzi A, de Billy E, Locatelli F, Vinci M. Int J Mol Sci. 2020 Sep 15;21(18). pii: ijms21186763. doi: 10.3390/ijms21186763. PubMed |
HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation.
Magupalli VG, Negro R, Tian Y, Hauenstein AV, Di Caprio G, Skillern W, Deng Q, Orning P, Alam HB, Maliga Z, Sharif H, Hu JJ, Evavold CL, Kagan JC, Schmidt FI, Fitzgerald KA, Kirchhausen T, Li Y, Wu H.
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| mTOR-mediated cancer drug resistance suppresses autophagy and generates a druggable metabolic vulnerability. Gremke N, Polo P, Dort A, Schneikert J, Elmshauser S, Brehm C, Klingmuller U, Schmitt A, Reinhardt HC, Timofeev O, Wanzel M, Stiewe T. Nat Commun. 2020 Sep 17;11(1):4684. doi: 10.1038/s41467-020-18504-7. PubMed |
| Genome-Scale CRISPR Screening for Regulators of Cell Fate Transitions. Carlini V, Gretarsson KH, Hackett JA. Methods Mol Biol. 2021;2214:91-108. doi: 10.1007/978-1-0716-0958-3_7. PubMed |
| Cholesterol 25-Hydroxylase inhibits SARS-CoV-2 and other coronaviruses by depleting membrane cholesterol. Wang S, Li W, Hui H, Tiwari SK, Zhang Q, Croker BA, Rawlings S, Smith D, Carlin AF, Rana TM. EMBO J. 2020 Nov 2;39(21):e106057. doi: 10.15252/embj.2020106057. Epub 2020 Oct 5. PubMed |
| The mechanistic role of alpha-synuclein in the nucleus: impaired nuclear function caused by familial Parkinson's disease SNCA mutations. Chen V, Moncalvo M, Tringali D, Tagliafierro L, Shriskanda A, Ilich E, Dong W, Kantor B, Chiba-Falek O. Hum Mol Genet. 2020 Nov 4;29(18):3107-3121. doi: 10.1093/hmg/ddaa183. PubMed |
| Telomere dysfunction activates YAP1 to drive tissue inflammation. Chakravarti D, Hu B, Mao X, Rashid A, Li J, Li J, Liao WT, Whitley EM, Dey P, Hou P, LaBella KA, Chang A, Wang G, Spring DJ, Deng P, Zhao D, Liang X, Lan Z, Lin Y, Sarkar S, Terranova C, Deribe YL, Blutt SE, Okhuysen P, Zhang J, Vilar E, Nielsen OH, Dupont A, Younes M, Patel KR, Shroyer NF, Rai K, Estes MK, Wang YA, Bertuch AA, DePinho RA. Nat Commun. 2020 Sep 21;11(1):4766. doi: 10.1038/s41467-020-18420-w. PubMed |
| Generation of Combinatorial Lentiviral Vectors Expressing Multiple Anti-Hepatitis C Virus shRNAs and Their Validation on a Novel HCV Replicon Double Reporter Cell Line. Elbadawy HM, Mohammed Abdul MI, Aljuhani N, Vitiello A, Ciccarese F, Shaker MA, Eltahir HM, Palu G, Di Antonio V, Ghassabian H, Del Vecchio C, Salata C, Franchin E, Ponterio E, Bahashwan S, Thabet K, Abouzied MM, Shehata AM, Parolin C, Calistri A, Alvisi G. Viruses. 2020 Sep 18;12(9). pii: v12091044. doi: 10.3390/v12091044. PubMed |
| Pan-cancer multi-omics analysis and orthogonal experimental assessment of epigenetic driver genes. Halaburkova A, Cahais V, Novoloaca A, Araujo MGDS, Khoueiry R, Ghantous A, Herceg Z. Genome Res. 2020 Oct;30(10):1517-1532. doi: 10.1101/gr.268292.120. Epub 2020 Sep 22. PubMed |
| PLRP2 selectively localizes synaptic membrane proteins via acyl-chain remodeling of phospholipids. Kuge H, Miyamoto I, Yagyu KI, Honke K. J Lipid Res. 2020 Dec;61(12):1747-1763. doi: 10.1194/jlr.RA120001087. Epub 2020 Sep 22. PubMed |
| Unique cellular protrusions mediate breast cancer cell migration by tethering to osteogenic cells. Muscarella AM, Dai W, Mitchell PG, Zhang W, Wang H, Jia L, Stossi F, Mancini MA, Chiu W, Zhang XH. NPJ Breast Cancer. 2020 Sep 7;6:42. doi: 10.1038/s41523-020-00183-8. eCollection 2020. PubMed |
| SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2. Clausen TM, Sandoval DR, Spliid CB, Pihl J, Perrett HR, Painter CD, Narayanan A, Majowicz SA, Kwong EM, McVicar RN, Thacker BE, Glass CA, Yang Z, Torres JL, Golden GJ, Bartels PL, Porell RN, Garretson AF, Laubach L, Feldman J, Yin X, Pu Y, Hauser BM, Caradonna TM, Kellman BP, Martino C, Gordts PLSM, Chanda SK, Schmidt AG, Godula K, Leibel SL, Jose J, Corbett KD, Ward AB, Carlin AF, Esko JD. Cell. 2020 Nov 12;183(4):1043-1057.e15. doi: 10.1016/j.cell.2020.09.033. Epub 2020 Sep 14. PubMed |
| FGFR1 Is Critical for RBL2 Loss-Driven Tumor Development and Requires PLCG1 Activation for Continued Growth of Small Cell Lung Cancer. Kim KB, Kim Y, Rivard CJ, Kim DW, Park KS. Cancer Res. 2020 Nov 15;80(22):5051-5062. doi: 10.1158/0008-5472.CAN-20-1453. Epub 2020 Sep 24. PubMed |
| MFSD7C switches mitochondrial ATP synthesis to thermogenesis in response to heme. Li Y, Ivica NA, Dong T, Papageorgiou DP, He Y, Brown DR, Kleyman M, Hu G, Chen WW, Sullivan LB, Del Rosario A, Hammond PT, Vander Heiden MG, Chen J. Nat Commun. 2020 Sep 24;11(1):4837. doi: 10.1038/s41467-020-18607-1. PubMed |
| A new agarose-based microsystem to investigate cell response to prolonged confinement. Prunet A, Lefort S, Delanoe-Ayari H, Laperrousaz B, Simon G, Barentin C, Saci S, Argoul F, Guyot B, Rieu JP, Gobert S, Maguer-Satta V, Riviere C. Lab Chip. 2020 Nov 7;20(21):4016-4030. doi: 10.1039/d0lc00732c. Epub 2020 Sep 25. PubMed |
| Cholesterol Pathway Inhibition Induces TGF-beta Signaling to Promote Basal Differentiation in Pancreatic Cancer. Gabitova-Cornell L, Surumbayeva A, Peri S, Franco-Barraza J, Restifo D, Weitz N, Ogier C, Goldman AR, Hartman TR, Francescone R, Tan Y, Nicolas E, Shah N, Handorf EA, Cai KQ, O'Reilly AM, Sloma I, Chiaverelli R, Moffitt RA, Khazak V, Fang CY, Golemis EA, Cukierman E, Astsaturov I. Cancer Cell. 2020 Oct 12;38(4):567-583.e11. doi: 10.1016/j.ccell.2020.08.015. Epub 2020 Sep 24. PubMed |
| In Vitro Studies to Define the Cell-Surface and Intracellular Targets of Polyarginine-Conjugated Sodium Borocaptate as a Potential Delivery Agent for Boron Neutron Capture Therapy. Fujimura A, Yasui S, Igawa K, Ueda A, Watanabe K, Hanafusa T, Ichikawa Y, Yoshihashi S, Tsuchida K, Kamiya A, Furuya S. Cells. 2020 Sep 23;9(10). pii: cells9102149. doi: 10.3390/cells9102149. PubMed |
| Plasmodium berghei sporozoites in nonreplicative vacuole are eliminated by a PI3P-mediated autophagy-independent pathway. Bindschedler A, Wacker R, Egli J, Eickel N, Schmuckli-Maurer J, Franke-Fayard BM, Janse CJ, Heussler VT. Cell Microbiol. 2021 Jan;23(1):e13271. doi: 10.1111/cmi.13271. Epub 2020 Oct 8. PubMed |
| RPS5 interacts with the rabbit hemorrhagic disease virus 3' extremities region and plays a role in virus replication. Guo H, Zhu J, Miao Q, Qi R, Tang A, Liu C, Yang H, Yuan L, Liu G. Vet Microbiol. 2020 Oct;249:108858. doi: 10.1016/j.vetmic.2020.108858. Epub 2020 Sep 18. PubMed |
| Optimized Transgene Delivery Using Third-Generation Lentiviruses. Gill KP, Denham M. Curr Protoc Mol Biol. 2020 Dec;133(1):e125. doi: 10.1002/cpmb.125. PubMed |
| NFIA differentially controls adipogenic and myogenic gene program through distinct pathways to ensure brown and beige adipocyte differentiation. Hiraike Y, Waki H, Miyake K, Wada T, Oguchi M, Saito K, Tsutsumi S, Aburatani H, Yamauchi T, Kadowaki T. PLoS Genet. 2020 Sep 29;16(9):e1009044. doi: 10.1371/journal.pgen.1009044. eCollection 2020 Sep. PubMed |
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| Co-culture Systems of Drug-Treated Acute Myeloid Leukemia Cells and T Cells for In Vitro and In Vivo Study. Li Y, Su R, Chen J. STAR Protoc. 2020 Sep 18;1(2). doi: 10.1016/j.xpro.2020.100097. Epub 2020 Aug 28. PubMed |
| MYC Promotes Bone Marrow Stem Cell Dysfunction in Fanconi Anemia. Rodriguez A, Zhang K, Farkkila A, Filiatrault J, Yang C, Velazquez M, Furutani E, Goldman DC, Garcia de Teresa B, Garza-Mayen G, McQueen K, Sambel LA, Molina B, Torres L, Gonzalez M, Vadillo E, Pelayo R, Fleming WH, Grompe M, Shimamura A, Hautaniemi S, Greenberger J, Frias S, Parmar K, D'Andrea AD. Cell Stem Cell. 2021 Jan 7;28(1):33-47.e8. doi: 10.1016/j.stem.2020.09.004. Epub 2020 Sep 29. PubMed |
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| Requisite Chromatin Remodeling for Myeloid and Erythroid Lineage Differentiation from Erythromyeloid Progenitors. Wu J, Krchma K, Lee HJ, Prabhakar S, Wang X, Zhao H, Xing X, Seong RH, Fremont DH, Artyomov MN, Wang T, Choi K. Cell Rep. 2020 Nov 17;33(7):108395. doi: 10.1016/j.celrep.2020.108395. PubMed |
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| Stabilization of ERK-Phosphorylated METTL3 by USP5 Increases m(6)A Methylation. Sun HL, Zhu AC, Gao Y, Terajima H, Fei Q, Liu S, Zhang L, Zhang Z, Harada BT, He YY, Bissonnette MB, Hung MC, He C. Mol Cell. 2020 Nov 19;80(4):633-647.e7. doi: 10.1016/j.molcel.2020.10.026. PubMed |
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| Mutations in Spliceosomal Genes PPIL1 and PRP17 Cause Neurodegenerative Pontocerebellar Hypoplasia with Microcephaly. Chai G, Webb A, Li C, Antaki D, Lee S, Breuss MW, Lang N, Stanley V, Anzenberg P, Yang X, Marshall T, Gaffney P, Wierenga KJ, Chung BH, Tsang MH, Pais LS, Lovgren AK, VanNoy GE, Rehm HL, Mirzaa G, Leon E, Diaz J, Neumann A, Kalverda AP, Manfield IW, Parry DA, Logan CV, Johnson CA, Bonthron DT, Valleley EMA, Issa MY, Abdel-Ghafar SF, Abdel-Hamid MS, Jennings P, Zaki MS, Sheridan E, Gleeson JG. Neuron. 2021 Jan 20;109(2):241-256.e9. doi: 10.1016/j.neuron.2020.10.035. Epub 2020 Nov 20. PubMed |
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| Genome-scale CRISPR screening at high sensitivity with an empirically designed sgRNA library. Henkel L, Rauscher B, Schmitt B, Winter J, Boutros M. BMC Biol. 2020 Nov 23;18(1):174. doi: 10.1186/s12915-020-00905-1. PubMed |
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| Wnt16 signaling promotes osteoblast differentiation of periosteal derived cells in vitro and in vivo. Jin Y, Sun X, Pei F, Zhao Z, Mao J. PeerJ. 2020 Nov 24;8:e10374. doi: 10.7717/peerj.10374. eCollection 2020. PubMed |
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Binding and transport of SFPQ-RNA granules by KIF5A/KLC1 motors promotes axon survival.
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| Measuring Circadian Rhythms in Human Cells. Du NH, Brown SA. Methods Mol Biol. 2021;2130:53-67. doi: 10.1007/978-1-0716-0381-9_4. PubMed |
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| Bidirectional perisomatic inhibitory plasticity of a Fos neuronal network. Yap EL, Pettit NL, Davis CP, Nagy MA, Harmin DA, Golden E, Dagliyan O, Lin C, Rudolph S, Sharma N, Griffith EC, Harvey CD, Greenberg ME. Nature. 2021 Feb;590(7844):115-121. doi: 10.1038/s41586-020-3031-0. Epub 2020 Dec 9. PubMed |
| Heterogeneous bone-marrow stromal progenitors drive myelofibrosis via a druggable alarmin axis. Leimkuhler NB, Gleitz HFE, Ronghui L, Snoeren IAM, Fuchs SNR, Nagai JS, Banjanin B, Lam KH, Vogl T, Kuppe C, Stalmann USA, Busche G, Kreipe H, Gutgemann I, Krebs P, Banz Y, Boor P, Tai EW, Brummendorf TH, Koschmieder S, Crysandt M, Bindels E, Kramann R, Costa IG, Schneider RK. Cell Stem Cell. 2021 Apr 1;28(4):637-652.e8. doi: 10.1016/j.stem.2020.11.004. Epub 2020 Dec 9. PubMed |
| A Novel Nonsense GLI3 Variant Is Associated With Polydactyly and Syndactyly in a Family by Blocking the Sonic Hedgehog Signaling Pathway. Xiang Y, Li X, Zhan Z, Feng J, Cai H, Li Y, Fu Q, Xu Y, Jiang H, Zhang X. Front Genet. 2020 Nov 10;11:542004. doi: 10.3389/fgene.2020.542004. eCollection 2020. PubMed |
| Inhibition of Wnt signaling by Frizzled7 antibody-coated nanoshells sensitizes triple-negative breast cancer cells to the autophagy regulator chloroquine. Wang J, Dang MN, Day ES. Nano Res. 2020 Jun;13(6):1693-1703. doi: 10.1007/s12274-020-2795-8. Epub 2020 Apr 25. PubMed |
| The long non-coding RNA LUCAT1 is a negative feedback regulator of interferon responses in humans. Agarwal S, Vierbuchen T, Ghosh S, Chan J, Jiang Z, Kandasamy RK, Ricci E, Fitzgerald KA. Nat Commun. 2020 Dec 11;11(1):6348. doi: 10.1038/s41467-020-20165-5. PubMed |
| SNAIL regulates gastric carcinogenesis through CCN3 and NEFL. Chen R, Masuo K, Yogo A, Yokoyama S, Sugiyama A, Seno H, Yoshizawa A, Takaishi S. Carcinogenesis. 2021 Feb 25;42(2):190-201. doi: 10.1093/carcin/bgaa133. PubMed |
| Satellite cell expansion is mediated by P-eIF2alpha-dependent Tacc3 translation. Fujita R, Jamet S, Lean G, Cheng HCM, Hebert S, Kleinman CL, Crist C. Development. 2021 Jan 20;148(2). pii: dev.194480. doi: 10.1242/dev.194480. PubMed |
| Genome-Scale Perturbation of Long Noncoding RNA Expression Using CRISPR Interference. Liu SJ, Horlbeck MA, Weissman JS, Lim DA. Methods Mol Biol. 2021;2254:323-338. doi: 10.1007/978-1-0716-1158-6_20. PubMed |
Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q.
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| An activity-dependent local transport regulation via degradation and synthesis of KIF17 underlying cognitive flexibility. Iwata S, Morikawa M, Takei Y, Hirokawa N. Sci Adv. 2020 Dec 16;6(51). pii: 6/51/eabc8355. doi: 10.1126/sciadv.abc8355. Print 2020 Dec. PubMed |
| Erythroid Differentiation and Heme Biosynthesis Are Dependent on a Shift in the Balance of Mitochondrial Fusion and Fission Dynamics. Gonzalez-Ibanez AM, Ruiz LM, Jensen E, Echeverria CA, Romero V, Stiles L, Shirihai OS, Elorza AA. Front Cell Dev Biol. 2020 Nov 23;8:592035. doi: 10.3389/fcell.2020.592035. eCollection 2020. PubMed |
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| The TOP vector: a new high-titer lentiviral construct for delivery of sgRNAs and transgenes to primary T cells. Humes D, Rainwater S, Overbaugh J. Mol Ther Methods Clin Dev. 2020 Oct 27;20:30-38. doi: 10.1016/j.omtm.2020.10.020. eCollection 2021 Mar 12. PubMed |
| TMEM41B Is a Pan-flavivirus Host Factor. Hoffmann HH, Schneider WM, Rozen-Gagnon K, Miles LA, Schuster F, Razooky B, Jacobson E, Wu X, Yi S, Rudin CM, MacDonald MR, McMullan LK, Poirier JT, Rice CM. Cell. 2021 Jan 7;184(1):133-148.e20. doi: 10.1016/j.cell.2020.12.005. Epub 2020 Dec 9. PubMed |
| Resveratrol Activates Natural Killer Cells through Akt- and mTORC2-Mediated c-Myb Upregulation. Lee YJ, Kim J. Int J Mol Sci. 2020 Dec 16;21(24). pii: ijms21249575. doi: 10.3390/ijms21249575. PubMed |
| ANKRD26 recruits PIDD1 to centriolar distal appendages to activate the PIDDosome following centrosome amplification. Evans LT, Anglen T, Scott P, Lukasik K, Loncarek J, Holland AJ. EMBO J. 2021 Feb 15;40(4):e105106. doi: 10.15252/embj.2020105106. Epub 2020 Dec 22. PubMed |
| Separate signaling events control TCR downregulation and T cell activation in primary human T cells. van der Donk LEH, Ates LS, van der Spek J, Tukker LM, Geijtenbeek TBH, van Heijst JWJ. Immun Inflamm Dis. 2021 Mar;9(1):223-238. doi: 10.1002/iid3.383. Epub 2020 Dec 22. PubMed |
| Clustering of desmosomal cadherins by desmoplakin is essential for cell-cell adhesion. Wanuske MT, Brantschen D, Schinner C, Studle C, Walter E, Hiermaier M, Vielmuth F, Waschke J, Spindler V. Acta Physiol (Oxf). 2021 Apr;231(4):e13609. doi: 10.1111/apha.13609. Epub 2021 Jan 19. PubMed |
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| Manipulation of the human tRNA pool reveals distinct tRNA sets that act in cellular proliferation or cell cycle arrest. Aharon-Hefetz N, Frumkin I, Mayshar Y, Dahan O, Pilpel Y, Rak R. Elife. 2020 Dec 24;9. pii: 58461. doi: 10.7554/eLife.58461. PubMed |
| Massively parallel functional testing of MSH2 missense variants conferring Lynch syndrome risk. Jia X, Burugula BB, Chen V, Lemons RM, Jayakody S, Maksutova M, Kitzman JO. Am J Hum Genet. 2021 Jan 7;108(1):163-175. doi: 10.1016/j.ajhg.2020.12.003. Epub 2020 Dec 23. PubMed |
| Immunogenic Chemotherapy Enhances Recruitment of CAR-T Cells to Lung Tumors and Improves Antitumor Efficacy when Combined with Checkpoint Blockade. Srivastava S, Furlan SN, Jaeger-Ruckstuhl CA, Sarvothama M, Berger C, Smythe KS, Garrison SM, Specht JM, Lee SM, Amezquita RA, Voillet V, Muhunthan V, Yechan-Gunja S, Pillai SPS, Rader C, Houghton AM, Pierce RH, Gottardo R, Maloney DG, Riddell SR. Cancer Cell. 2021 Feb 8;39(2):193-208.e10. doi: 10.1016/j.ccell.2020.11.005. Epub 2020 Dec 24. PubMed |
| Discovery of cellular substrates of human RNA-decapping enzyme DCP2 using a stapled bicyclic peptide inhibitor. Luo Y, Schofield JA, Na Z, Hann T, Simon MD, Slavoff SA. Cell Chem Biol. 2021 Apr 15;28(4):463-474.e7. doi: 10.1016/j.chembiol.2020.12.003. Epub 2020 Dec 22. PubMed |
| A CRISPR-Cas13a Based Strategy That Tracks and Degrades Toxic RNA in Myotonic Dystrophy Type 1. Zhang N, Bewick B, Xia G, Furling D, Ashizawa T. Front Genet. 2020 Dec 10;11:594576. doi: 10.3389/fgene.2020.594576. eCollection 2020. PubMed |
| Modeling Rett Syndrome With Human Patient-Specific Forebrain Organoids. Gomes AR, Fernandes TG, Vaz SH, Silva TP, Bekman EP, Xapelli S, Duarte S, Ghazvini M, Gribnau J, Muotri AR, Trujillo CA, Sebastiao AM, Cabral JMS, Diogo MM. Front Cell Dev Biol. 2020 Dec 10;8:610427. doi: 10.3389/fcell.2020.610427. eCollection 2020. PubMed |
| Lentiviral vector with a radiation-inducible promoter, carrying the ING4 gene, mediates radiosensitization controlled by radiotherapy in cervical cancer cells. Ma T, Guo R, Wang X, Shen WT, Zhu M, Jin YN, Xu HP. Oncol Lett. 2021 Jan;21(1):67. doi: 10.3892/ol.2020.12328. Epub 2020 Nov 25. PubMed |
| USP22 controls necroptosis by regulating receptor-interacting protein kinase 3 ubiquitination. Roedig J, Kowald L, Juretschke T, Karlowitz R, Ahangarian Abhari B, Roedig H, Fulda S, Beli P, van Wijk SJ. EMBO Rep. 2021 Feb 3;22(2):e50163. doi: 10.15252/embr.202050163. Epub 2020 Dec 28. PubMed |
| Differential effects of RASA3 mutations on hematopoiesis are profoundly influenced by genetic background and molecular variant. Robledo RF, Ciciotte SL, Graber JH, Zhao Y, Lambert AJ, Gwynn B, Maki NJ, Brindley EC, Hartman E, Blanc L, Peters LL. PLoS Genet. 2020 Dec 28;16(12):e1008857. doi: 10.1371/journal.pgen.1008857. eCollection 2020 Dec. PubMed |
| Differential Regulation of Cancer Progression by CDK4/6 Plays a Central Role in DNA Replication and Repair Pathways. Dai M, Boudreault J, Wang N, Poulet S, Daliah G, Yan G, Moamer A, Burgos SA, Sabri S, Ali S, Lebrun JJ. Cancer Res. 2021 Mar 1;81(5):1332-1346. doi: 10.1158/0008-5472.CAN-20-2121. Epub 2020 Dec 28. PubMed |
| Evaluation of Structurally Distorted Split GFP Fluorescent Sensors for Cell-Based Detection of Viral Proteolytic Activity. Guerreiro MR, Fernandes AR, Coroadinha AS. Sensors (Basel). 2020 Dec 23;21(1). pii: s21010024. doi: 10.3390/s21010024. PubMed |
| Genetic engineering of human and mouse CD4(+) and CD8(+) Tregs using lentiviral vectors encoding chimeric antigen receptors. Vimond N, Lasselin J, Anegon I, Guillonneau C, Bezie S. Mol Ther Methods Clin Dev. 2020 Nov 17;20:69-85. doi: 10.1016/j.omtm.2020.11.008. eCollection 2021 Mar 12. PubMed |
| An Improved Protocol for the Production of Lentiviral Vectors. Brown LY, Dong W, Kantor B. STAR Protoc. 2020 Oct 27;1(3):100152. doi: 10.1016/j.xpro.2020.100152. eCollection 2020 Dec 18. PubMed |
| P2X-GCaMPs as Versatile Tools for Imaging Extracellular ATP Signaling. Ollivier M, Beudez J, Linck N, Grutter T, Compan V, Rassendren F. eNeuro. 2021 Jan 28;8(1). pii: ENEURO.0185-20.2020. doi: 10.1523/ENEURO.0185-20.2020. Print 2021 Jan-Feb. PubMed |
| LncRNA FTX Promotes Colorectal Cancer Cells Migration and Invasion by miRNA-590-5p/RBPJ Axis. Chen GQ, Liao ZM, Liu J, Li F, Huang D, Zhou YD. Biochem Genet. 2021 Apr;59(2):560-573. doi: 10.1007/s10528-020-10017-8. Epub 2021 Jan 3. PubMed |
| SARS-CoV-2 entry into human airway organoids is serine protease-mediated and facilitated by the multibasic cleavage site. Mykytyn AZ, Breugem TI, Riesebosch S, Schipper D, van den Doel PB, Rottier RJ, Lamers MM, Haagmans BL. Elife. 2021 Jan 4;10. pii: 64508. doi: 10.7554/eLife.64508. PubMed |
| Transcriptional regulation of VEGFA expression in T-regulatory cells from breast cancer patients. Kajal K, Bose S, Panda AK, Chakraborty D, Chakraborty S, Pati S, Sarkar T, Dhar S, Roy D, Saha S, Sa G. Cancer Immunol Immunother. 2021 Jul;70(7):1877-1891. doi: 10.1007/s00262-020-02808-0. Epub 2021 Jan 4. PubMed |
| ZBP1 promotes LPS-induced cell death and IL-1beta release via RHIM-mediated interactions with RIPK1. Muendlein HI, Connolly WM, Magri Z, Smirnova I, Ilyukha V, Gautam A, Degterev A, Poltorak A. Nat Commun. 2021 Jan 4;12(1):86. doi: 10.1038/s41467-020-20357-z. PubMed |
| Functional Genomics Identify Distinct and Overlapping Genes Mediating Resistance to Different Classes of Heterobifunctional Degraders of Oncoproteins. Shirasaki R, Matthews GM, Gandolfi S, de Matos Simoes R, Buckley DL, Raja Vora J, Sievers QL, Bruggenthies JB, Dashevsky O, Poarch H, Tang H, Bariteau MA, Sheffer M, Hu Y, Downey-Kopyscinski SL, Hengeveld PJ, Glassner BJ, Dhimolea E, Ott CJ, Zhang T, Kwiatkowski NP, Laubach JP, Schlossman RL, Richardson PG, Culhane AC, Groen RWJ, Fischer ES, Vazquez F, Tsherniak A, Hahn WC, Levy J, Auclair D, Licht JD, Keats JJ, Boise LH, Ebert BL, Bradner JE, Gray NS, Mitsiades CS. Cell Rep. 2021 Jan 5;34(1):108532. doi: 10.1016/j.celrep.2020.108532. PubMed |
| Endothelial Klf2-Foxp1-TGFbeta signal mediates the inhibitory effects of simvastatin on maladaptive cardiac remodeling. Li H, Wang Y, Liu J, Chen X, Duan Y, Wang X, Shen Y, Kuang Y, Zhuang T, Tomlinson B, Chan P, Yu Z, Cheng Y, Zhang L, Liu Z, Zhang Y, Zhao Z, Zhang Q, Liu J. Theranostics. 2021 Jan 1;11(4):1609-1625. doi: 10.7150/thno.48153. eCollection 2021. PubMed |
| Mechanism and restoration strategy of lysosomal abnormalities induced by urinary protein overload in proximal tubule epithelial cells. Li X, Zou T, Wang S, Wu H, Wu M, Liu Z, Liu H. Dev Dyn. 2021 Jan 6. doi: 10.1002/dvdy.297. PubMed |
| The serine-48 residue of nucleolar phosphoprotein nucleophosmin-1 plays critical role in subcellular localization and interaction with porcine circovirus type 3 capsid protein. Zhou J, Li J, Li H, Zhang Y, Dong W, Jin Y, Yan Y, Gu J, Zhou J. Vet Res. 2021 Jan 7;52(1):4. doi: 10.1186/s13567-020-00876-9. PubMed |
| Ferroptosis induces membrane blebbing in placental trophoblasts. Kajiwara K, Beharier O, Chng CP, Goff JP, Ouyang Y, St Croix CM, Huang C, Kagan VE, Hsia KJ, Sadovsky Y. J Cell Sci. 2022 Mar 1;135(5). pii: jcs.255737. doi: 10.1242/jcs.255737. Epub 2021 Apr 20. PubMed |
| Inhibition of caspase-3-mediated GSDME-derived pyroptosis aids in noncancerous tissue protection of squamous cell carcinoma patients during cisplatin-based chemotherapy. Huang Z, Zhang Q, Wang Y, Chen R, Wang Y, Huang Z, Zhou G, Li H, Rui X, Jin T, Li S, Zhang Y, Huang Z. Am J Cancer Res. 2020 Dec 1;10(12):4287-4307. eCollection 2020. PubMed |
| Directly Reprogrammed Neurons Express MAPT and APP Splice Variants Pertinent to Ageing and Neurodegeneration. Habekost M, Qvist P, Denham M, Holm IE, Jorgensen AL. Mol Neurobiol. 2021 May;58(5):2075-2087. doi: 10.1007/s12035-020-02258-w. Epub 2021 Jan 7. PubMed |
| Interaction between SNAI2 and MYOD enhances oncogenesis and suppresses differentiation in Fusion Negative Rhabdomyosarcoma. Pomella S, Sreenivas P, Gryder BE, Wang L, Milewski D, Cassandri M, Baxi K, Hensch NR, Carcarino E, Song Y, Chou HC, Yohe ME, Stanton BZ, Amadio B, Caruana I, De Stefanis C, De Vito R, Locatelli F, Chen Y, Chen EY, Houghton P, Khan J, Rota R, Ignatius MS. Nat Commun. 2021 Jan 8;12(1):192. doi: 10.1038/s41467-020-20386-8. PubMed |
| SLE non-coding genetic risk variant determines the epigenetic dysfunction of an immune cell specific enhancer that controls disease-critical microRNA expression. Hou G, Harley ITW, Lu X, Zhou T, Xu N, Yao C, Qin Y, Ouyang Y, Ma J, Zhu X, Yu X, Xu H, Dai D, Ding H, Yin Z, Ye Z, Deng J, Zhou M, Tang Y, Namjou B, Guo Y, Weirauch MT, Kottyan LC, Harley JB, Shen N. Nat Commun. 2021 Jan 8;12(1):135. doi: 10.1038/s41467-020-20460-1. PubMed |
| PRMT1 enhances oncogenic arginine methylation of NONO in colorectal cancer. Yin XK, Wang YL, Wang F, Feng WX, Bai SM, Zhao WW, Feng LL, Wei MB, Qin CL, Wang F, Chen ZL, Yi HJ, Huang Y, Xie PY, Kim T, Wang YN, Hou JW, Li CW, Liu Q, Fan XJ, Hung MC, Wan XB. Oncogene. 2021 Feb;40(7):1375-1389. doi: 10.1038/s41388-020-01617-0. Epub 2021 Jan 8. PubMed |
| The TGF-beta superfamily cytokine Activin-A is induced during autoimmune neuroinflammation and drives pathogenic Th17 cell differentiation. Wu B, Zhang S, Guo Z, Bi Y, Zhou M, Li P, Seyedsadr M, Xu X, Li JL, Markovic-Plese S, Wan YY. Immunity. 2021 Feb 9;54(2):308-323.e6. doi: 10.1016/j.immuni.2020.12.010. Epub 2021 Jan 8. PubMed |
| Temperature is a key determinant of alpha- and beta-synuclein membrane interactions in neurons. Ramalingam N, Dettmer U. J Biol Chem. 2021 Jan-Jun;296:100271. doi: 10.1016/j.jbc.2021.100271. Epub 2021 Jan 9. PubMed |
| Ectopic Expression of Genotype 1 Hepatitis E Virus ORF4 Increases Genotype 3 HEV Viral Replication in Cell Culture. Yadav KK, Boley PA, Fritts Z, Kenney SP. Viruses. 2021 Jan 7;13(1). pii: v13010075. doi: 10.3390/v13010075. PubMed |
| Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape. Koenig PA, Das H, Liu H, Kummerer BM, Gohr FN, Jenster LM, Schiffelers LDJ, Tesfamariam YM, Uchima M, Wuerth JD, Gatterdam K, Ruetalo N, Christensen MH, Fandrey CI, Normann S, Todtmann JMP, Pritzl S, Hanke L, Boos J, Yuan M, Zhu X, Schmid-Burgk JL, Kato H, Schindler M, Wilson IA, Geyer M, Ludwig KU, Hallberg BM, Wu NC, Schmidt FI. Science. 2021 Feb 12;371(6530). pii: science.abe6230. doi: 10.1126/science.abe6230. Epub 2021 Jan 12. PubMed |
| Enhanced Expression of miR-181b in B Cells of CLL Improves the Anti-Tumor Cytotoxic T Cell Response. Di Marco M, Veschi S, Lanuti P, Ramassone A, Pacillo S, Pagotto S, Pepe F, George-William JN, Curcio C, Marchisio M, Miscia S, Innocenti I, Autore F, Vannata B, Di Gregorio P, Di Gioacchino M, Valentinuzzi S, Iezzi M, Mariani-Costantini R, Larocca LM, Laurenti L, Veronese A, Visone R. Cancers (Basel). 2021 Jan 12;13(2). pii: cancers13020257. doi: 10.3390/cancers13020257. PubMed |
| SIX2 and SIX3 coordinately regulate functional maturity and fate of human pancreatic beta cells. Bevacqua RJ, Lam JY, Peiris H, Whitener RL, Kim S, Gu X, Friedlander MSH, Kim SK. Genes Dev. 2021 Feb 1;35(3-4):234-249. doi: 10.1101/gad.342378.120. Epub 2021 Jan 14. PubMed |
| HAND1 and BARX1 Act as Transcriptional and Anatomic Determinants of Malignancy in Gastrointestinal Stromal Tumor. Hemming ML, Coy S, Lin JR, Andersen JL, Przybyl J, Mazzola E, Abdelhamid Ahmed AH, van de Rijn M, Sorger PK, Armstrong SA, Demetri GD, Santagata S. Clin Cancer Res. 2021 Mar 15;27(6):1706-1719. doi: 10.1158/1078-0432.CCR-20-3538. Epub 2021 Jan 15. PubMed |
| m(6) A deposition is regulated by PRMT1-mediated arginine methylation of METTL14 in its disordered C-terminal region. Wang Z, Pan Z, Adhikari S, Harada BT, Shen L, Yuan W, Abeywardana T, Al-Hadid Q, Stark JM, He C, Lin L, Yang Y. EMBO J. 2021 Mar 1;40(5):e106309. doi: 10.15252/embj.2020106309. Epub 2021 Jan 18. PubMed |
| Autophagy activation, lipotoxicity and lysosomal membrane permeabilization synergize to promote pimozide- and loperamide-induced glioma cell death. Meyer N, Henkel L, Linder B, Zielke S, Tascher G, Trautmann S, Geisslinger G, Munch C, Fulda S, Tegeder I, Kogel D. Autophagy. 2021 Nov;17(11):3424-3443. doi: 10.1080/15548627.2021.1874208. Epub 2021 Jan 19. PubMed |
| Deletion of Cbl-b inhibits CD8(+) T-cell exhaustion and promotes CAR T-cell function. Kumar J, Kumar R, Kumar Singh A, Tsakem EL, Kathania M, Riese MJ, Theiss AL, Davila ML, Venuprasad K. J Immunother Cancer. 2021 Jan;9(1). pii: jitc-2020-001688. doi: 10.1136/jitc-2020-001688. PubMed |
| Tetracyclines promote survival and fitness in mitochondrial disease models. Perry EA, Bennett CF, Luo C, Balsa E, Jedrychowski M, O'Malley KE, Latorre-Muro P, Ladley RP, Reda K, Wright PM, Gygi SP, Myers AG, Puigserver P. Nat Metab. 2021 Jan;3(1):33-42. doi: 10.1038/s42255-020-00334-y. Epub 2021 Jan 18. PubMed |
| Cross-talk Between Histone and DNA Methylation Mediates Bone Loss in Hind Limb Unloading. Li B, Zhao J, Ma J, Chen W, Zhou C, Wei W, Li S, Li G, Xin G, Zhang Y, Liu J, Wang Y, Ma X. J Bone Miner Res. 2021 May;36(5):956-967. doi: 10.1002/jbmr.4253. Epub 2021 Feb 10. PubMed |
| The phosphatidylinositol 3-phosphate-binding protein SNX4 controls ATG9A recycling and autophagy. Ravussin A, Brech A, Tooze SA, Stenmark H. J Cell Sci. 2021 Feb 10;134(3). pii: jcs.250670. doi: 10.1242/jcs.250670. PubMed |
CRNKL1 Is a Highly Selective Regulator of Intron-Retaining HIV-1 and Cellular mRNAs.
Xiao H, Wyler E, Milek M, Grewe B, Kirchner P, Ekici A, Silva ABOV, Jungnickl D, Full F, Thomas M, Landthaler M, Ensser A, Uberla K.
mBio. 2021 Jan 19;12(1). pii: mBio.02525-20. doi: 10.1128/mBio.02525-20.
PubMed
Associated Plasmids |
| A DYRK1B-dependent pathway suppresses rDNA transcription in response to DNA damage. Dong C, An L, Yu CH, Huen MSY. Nucleic Acids Res. 2021 Feb 22;49(3):1485-1496. doi: 10.1093/nar/gkaa1290. PubMed |
ER-directed TREX1 limits cGAS activation at micronuclei.
Mohr L, Toufektchan E, von Morgen P, Chu K, Kapoor A, Maciejowski J.
Mol Cell. 2021 Jan 12. pii: S1097-2765(20)30958-8. doi: 10.1016/j.molcel.2020.12.037.
PubMed
Associated Plasmids |
| Further evidence supporting a potential role for ADH1B in obesity. Morales LD, Cromack DT, Tripathy D, Fourcaudot M, Kumar S, Curran JE, Carless M, Goring HHH, Hu SL, Lopez-Alvarenga JC, Garske KM, Pajukanta P, Small KS, Glastonbury CA, Das SK, Langefeld C, Hanson RL, Hsueh WC, Norton L, Arya R, Mummidi S, Blangero J, DeFronzo RA, Duggirala R, Jenkinson CP. Sci Rep. 2021 Jan 21;11(1):1932. doi: 10.1038/s41598-020-80563-z. PubMed |
| T cell receptor-dependent S-acylation of ZAP-70 controls activation of T cells. Tewari R, Shayahati B, Fan Y, Akimzhanov AM. J Biol Chem. 2021 Jan-Jun;296:100311. doi: 10.1016/j.jbc.2021.100311. Epub 2021 Jan 19. PubMed |
| BMI1 enables extensive expansion of functional erythroblasts from human peripheral blood mononuclear cells. Liu S, Wu M, Lancelot M, Deng J, Gao Y, Roback JD, Chen T, Cheng L. Mol Ther. 2021 May 5;29(5):1918-1932. doi: 10.1016/j.ymthe.2021.01.022. Epub 2021 Jan 21. PubMed |
| Furin cleavage of SARS-CoV-2 Spike promotes but is not essential for infection and cell-cell fusion. Papa G, Mallery DL, Albecka A, Welch LG, Cattin-Ortola J, Luptak J, Paul D, McMahon HT, Goodfellow IG, Carter A, Munro S, James LC. PLoS Pathog. 2021 Jan 25;17(1):e1009246. doi: 10.1371/journal.ppat.1009246. eCollection 2021 Jan. PubMed |
| Evasion of Innate Immunity Contributes to Small Cell Lung Cancer Progression and Metastasis. Zhu M, Huang Y, Bender ME, Girard L, Kollipara R, Eglenen-Polat B, Naito Y, Savage TK, Huffman KE, Koyama S, Kumanogoh A, Minna JD, Johnson JE, Akbay EA. Cancer Res. 2021 Apr 1;81(7):1813-1826. doi: 10.1158/0008-5472.CAN-20-2808. Epub 2021 Jan 25. PubMed |
| SFPQ regulates the accumulation of RNA foci and dipeptide repeat proteins from the expanded repeat mutation in C9orf72. Malnar M, Rogelj B. J Cell Sci. 2021 Feb 19;134(4). pii: jcs.256602. doi: 10.1242/jcs.256602. PubMed |
| DHODH inhibition synergizes with DNA-demethylating agents in the treatment of myelodysplastic syndromes. Kayamori K, Nagai Y, Zhong C, Kaito S, Shinoda D, Koide S, Kuribayashi W, Oshima M, Nakajima-Takagi Y, Yamashita M, Mimura N, Becker HJ, Izawa K, Yamazaki S, Iwano S, Miyawaki A, Ito R, Tohyama K, Lennox W, Sheedy J, Weetall M, Sakaida E, Yokote K, Iwama A. Blood Adv. 2021 Jan 26;5(2):438-450. doi: 10.1182/bloodadvances.2020001461. PubMed |
| G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling. Prentzell MT, Rehbein U, Cadena Sandoval M, De Meulemeester AS, Baumeister R, Brohee L, Berdel B, Bockwoldt M, Carroll B, Chowdhury SR, von Deimling A, Demetriades C, Figlia G, de Araujo MEG, Heberle AM, Heiland I, Holzwarth B, Huber LA, Jaworski J, Kedra M, Kern K, Kopach A, Korolchuk VI, van 't Land-Kuper I, Macias M, Nellist M, Palm W, Pusch S, Ramos Pittol JM, Reil M, Reintjes A, Reuter F, Sampson JR, Scheldeman C, Siekierska A, Stefan E, Teleman AA, Thomas LE, Torres-Quesada O, Trump S, West HD, de Witte P, Woltering S, Yordanov TE, Zmorzynska J, Opitz CA, Thedieck K. Cell. 2021 Feb 4;184(3):655-674.e27. doi: 10.1016/j.cell.2020.12.024. Epub 2021 Jan 25. PubMed |
| The Novel ALG-2 Target Protein CDIP1 Promotes Cell Death by Interacting with ESCRT-I and VAPA/B. Inukai R, Mori K, Kuwata K, Suzuki C, Maki M, Takahara T, Shibata H. Int J Mol Sci. 2021 Jan 25;22(3). pii: ijms22031175. doi: 10.3390/ijms22031175. PubMed |
| IDH1 mutations induce organelle defects via dysregulated phospholipids. Lita A, Pliss A, Kuzmin A, Yamasaki T, Zhang L, Dowdy T, Burks C, de Val N, Celiku O, Ruiz-Rodado V, Nicoli ER, Kruhlak M, Andresson T, Das S, Yang C, Schmitt R, Herold-Mende C, Gilbert MR, Prasad PN, Larion M. Nat Commun. 2021 Jan 27;12(1):614. doi: 10.1038/s41467-020-20752-6. PubMed |
| TALEN outperforms Cas9 in editing heterochromatin target sites. Jain S, Shukla S, Yang C, Zhang M, Fatma Z, Lingamaneni M, Abesteh S, Lane ST, Xiong X, Wang Y, Schroeder CM, Selvin PR, Zhao H. Nat Commun. 2021 Jan 27;12(1):606. doi: 10.1038/s41467-020-20672-5. PubMed |
| Depletion of Survivin suppresses docetaxel-induced apoptosis in HeLa cells by facilitating mitotic slippage. Han TL, Sha H, Ji J, Li YT, Wu DS, Lin H, Hu B, Jiang ZX. Sci Rep. 2021 Jan 27;11(1):2283. doi: 10.1038/s41598-021-81563-3. PubMed |
| A host receptor enables type 1 pilus-mediated pathogenesis of Escherichia coli pyelonephritis. McLellan LK, McAllaster MR, Kim AS, Tothova L, Olson PD, Pinkner JS, Daugherty AL, Hreha TN, Janetka JW, Fremont DH, Hultgren SJ, Virgin HW, Hunstad DA. PLoS Pathog. 2021 Jan 29;17(1):e1009314. doi: 10.1371/journal.ppat.1009314. eCollection 2021 Jan. PubMed |
| Prototypical oncogene family Myc defines unappreciated distinct lineage states of small cell lung cancer. Patel AS, Yoo S, Kong R, Sato T, Sinha A, Karam S, Bao L, Fridrikh M, Emoto K, Nudelman G, Powell CA, Beasley MB, Zhu J, Watanabe H. Sci Adv. 2021 Jan 29;7(5). pii: 7/5/eabc2578. doi: 10.1126/sciadv.abc2578. Print 2021 Jan. PubMed |
Plexin-B2 facilitates glioblastoma infiltration by modulating cell biomechanics.
Huang Y, Tejero R, Lee VK, Brusco C, Hannah T, Bertucci TB, Junqueira Alves C, Katsyv I, Kluge M, Foty R, Zhang B, Friedel CC, Dai G, Zou H, Friedel RH.
Commun Biol. 2021 Jan 29;4(1):145. doi: 10.1038/s42003-021-01667-4.
PubMed
Associated Plasmids |
| LncRNA H19 Suppresses Osteosarcomagenesis by Regulating snoRNAs and DNA Repair Protein Complexes. Xu A, Huang MF, Zhu D, Gingold JA, Bazer DA, Chang B, Wang D, Lai CC, Lemischka IR, Zhao R, Lee DF. Front Genet. 2021 Jan 15;11:611823. doi: 10.3389/fgene.2020.611823. eCollection 2020. PubMed |
| Generation of SARS-CoV-2 Spike Pseudotyped Virus for Viral Entry and Neutralization Assays: A 1-Week Protocol. Condor Capcha JM, Lambert G, Dykxhoorn DM, Salerno AG, Hare JM, Whitt MA, Pahwa S, Jayaweera DT, Shehadeh LA. Front Cardiovasc Med. 2021 Jan 15;7:618651. doi: 10.3389/fcvm.2020.618651. eCollection 2020. PubMed |
| SATB2 induction of a neural crest mesenchyme-like program drives melanoma invasion and drug resistance. Fazio M, van Rooijen E, Dang M, van de Hoek G, Ablain J, Mito JK, Yang S, Thomas A, Michael J, Fabo T, Modhurima R, Pessina P, Kaufman CK, Zhou Y, White RM, Zon LI. Elife. 2021 Feb 2;10. pii: 64370. doi: 10.7554/eLife.64370. PubMed |
| RNF168 regulates R-loop resolution and genomic stability in BRCA1/2-deficient tumors. Patel PS, Abraham KJ, Guturi KKN, Halaby MJ, Khan Z, Palomero L, Ho B, Duan S, St-Germain J, Algouneh A, Mateo F, El Ghamrasni S, Barbour H, Barnes DR, Beesley J, Sanchez O, Berman HK, Brown GW, Affar EB, Chenevix-Trench G, Antoniou AC, Arrowsmith CH, Raught B, Pujana MA, Mekhail K, Hakem A, Hakem R. J Clin Invest. 2021 Feb 1;131(3). pii: 140105. doi: 10.1172/JCI140105. PubMed |
| ATF3 downmodulates its new targets IFI6 and IFI27 to suppress the growth and migration of tongue squamous cell carcinoma cells. Xu L, Zu T, Li T, Li M, Mi J, Bai F, Liu G, Wen J, Li H, Brakebusch C, Wang X, Wu X. PLoS Genet. 2021 Feb 4;17(2):e1009283. doi: 10.1371/journal.pgen.1009283. eCollection 2021 Feb. PubMed |
| PTEN is required for the migration and invasion of Ras-transformed MDCK cells. Yan L, Tsujita K, Fujita Y, Itoh T. FEBS Lett. 2021 May;595(9):1303-1312. doi: 10.1002/1873-3468.14053. Epub 2021 Feb 20. PubMed |
| Distinct roles for the RNA-binding protein Staufen1 in prostate cancer. Marcellus KA, Crawford Parks TE, Almasi S, Jasmin BJ. BMC Cancer. 2021 Feb 4;21(1):120. doi: 10.1186/s12885-021-07844-2. PubMed |
| Engineering advanced logic and distributed computing in human CAR immune cells. Cho JH, Okuma A, Sofjan K, Lee S, Collins JJ, Wong WW. Nat Commun. 2021 Feb 4;12(1):792. doi: 10.1038/s41467-021-21078-7. PubMed |
| Discovery of Zika virus host dependency factors in trophoblasts using CRISPR/Cas9 screening. Rother M, Dimmler C, Weege F, Mollenkopf HJ, Meyer TF, Naumann M. J Virol Methods. 2021 Apr;290:114085. doi: 10.1016/j.jviromet.2021.114085. Epub 2021 Feb 2. PubMed |
| NAMPT/SIRT2-mediated inhibition of the p53-p21 signaling pathway is indispensable for maintenance and hematopoietic differentiation of human iPS cells. Xu Y, Nasri M, Dannenmann B, Mir P, Zahabi A, Welte K, Morishima T, Skokowa J. Stem Cell Res Ther. 2021 Feb 5;12(1):112. doi: 10.1186/s13287-021-02144-9. PubMed |
| Toll-like receptor 4 signaling activates ERG function in prostate cancer and provides a therapeutic target. Greulich BM, Plotnik JP, Jerde TJ, Hollenhorst PC. NAR Cancer. 2021 Jan 27;3(1):zcaa046. doi: 10.1093/narcan/zcaa046. eCollection 2021 Mar. PubMed |
| Optimized protocol for gene editing in adipocytes using CRISPR-Cas9 technology. Qiu Y, Ding Q. STAR Protoc. 2021 Jan 27;2(1):100307. doi: 10.1016/j.xpro.2021.100307. eCollection 2021 Mar 19. PubMed |
A pentameric protein ring with novel architecture is required for herpesviral packaging.
Didychuk AL, Gates SN, Gardner MR, Strong LM, Martin A, Glaunsinger BA.
Elife. 2021 Feb 8;10. pii: 62261. doi: 10.7554/eLife.62261.
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Associated Plasmids |
| SPRTN protease-cleaved MRE11 decreases DNA repair and radiosensitises cancer cells. Na J, Newman JA, Then CK, Syed J, Vendrell I, Torrecilla I, Ellermann S, Ramadan K, Fischer R, Kiltie AE. Cell Death Dis. 2021 Feb 8;12(2):165. doi: 10.1038/s41419-021-03437-w. PubMed |
| Identification of pannexin 1-regulated genes, interactome, and pathways in rhabdomyosarcoma and its tumor inhibitory interaction with AHNAK. Xiang X, Langlois S, St-Pierre ME, Blinder A, Charron P, Graber TE, Fowler SL, Baird SD, Bennett SAL, Alain T, Cowan KN. Oncogene. 2021 Mar;40(10):1868-1883. doi: 10.1038/s41388-020-01623-2. Epub 2021 Feb 9. PubMed |
| [Levels of sgRNA as a Major Factor Affecting CRISPRi Knockdown Efficiency in K562 Cells]. Wang Y, Xie Y, Dong ZC, Jiang XJ, Gong P, Lu J, Wan F. Mol Biol (Mosk). 2021 Jan-Feb;55(1):86-95. doi: 10.31857/S0026898421010146. PubMed |
| Spatial regulation of MCAK promotes cell polarization and focal adhesion turnover to drive robust cell migration. Zong H, Hazelbaker M, Moe C, Ems-McClung SC, Hu K, Walczak CE. Mol Biol Cell. 2021 Apr 1;32(7):590-604. doi: 10.1091/mbc.E20-05-0301. Epub 2021 Feb 10. PubMed |
| Gain-of-function p53 protein transferred via small extracellular vesicles promotes conversion of fibroblasts to a cancer-associated phenotype. Ma S, McGuire MH, Mangala LS, Lee S, Stur E, Hu W, Bayraktar E, Villar-Prados A, Ivan C, Wu SY, Yokoi A, Dasari SK, Jennings NB, Liu J, Lopez-Berestein G, Ram P, Sood AK. Cell Rep. 2021 Feb 9;34(6):108726. doi: 10.1016/j.celrep.2021.108726. PubMed |
| A conserved long noncoding RNA, GAPLINC, modulates the immune response during endotoxic shock. Vollmers AC, Covarrubias S, Kuang D, Shulkin A, Iwuagwu J, Katzman S, Song R, Viswanathan K, Vollmers C, Wakeland E, Carpenter S. Proc Natl Acad Sci U S A. 2021 Feb 16;118(7). pii: 2016648118. doi: 10.1073/pnas.2016648118. PubMed |
| LETR1 is a lymphatic endothelial-specific lncRNA governing cell proliferation and migration through KLF4 and SEMA3C. Ducoli L, Agrawal S, Sibler E, Kouno T, Tacconi C, Hon CC, Berger SD, Mullhaupt D, He Y, Kim J, D'Addio M, Dieterich LC, Carninci P, de Hoon MJL, Shin JW, Detmar M. Nat Commun. 2021 Feb 10;12(1):925. doi: 10.1038/s41467-021-21217-0. PubMed |
| Small molecule inhibitor of OGG1 blocks oxidative DNA damage repair at telomeres and potentiates methotrexate anticancer effects. Baquero JM, Benitez-Buelga C, Rajagopal V, Zhenjun Z, Torres-Ruiz R, Muller S, Hanna BMF, Loseva O, Wallner O, Michel M, Rodriguez-Perales S, Gad H, Visnes T, Helleday T, Benitez J, Osorio A. Sci Rep. 2021 Feb 10;11(1):3490. doi: 10.1038/s41598-021-82917-7. PubMed |
The Spike D614G mutation increases SARS-CoV-2 infection of multiple human cell types.
Daniloski Z, Jordan TX, Ilmain JK, Guo X, Bhabha G, tenOever BR, Sanjana NE.
Elife. 2021 Feb 11;10. pii: 65365. doi: 10.7554/eLife.65365.
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Associated Plasmids |
| Design of genetically encoded sensors to detect nucleosome ubiquitination in live cells. Dos Santos Passos C, Choi YS, Snow CD, Yao T, Cohen RE. J Cell Biol. 2021 Apr 5;220(4). pii: 211785. doi: 10.1083/jcb.201911130. PubMed |
| NOTCH1-driven UBR7 stimulates nucleotide biosynthesis to promote T cell acute lymphoblastic leukemia. Srivastava S, Sahu U, Zhou Y, Hogan AK, Sathyan KM, Bodner J, Huang J, Wong KA, Khalatyan N, Savas JN, Ntziachristos P, Ben-Sahra I, Foltz DR. Sci Adv. 2021 Jan 27;7(5). pii: 7/5/eabc9781. doi: 10.1126/sciadv.abc9781. Print 2021 Jan. PubMed |
| A synthetic mechanogenetic gene circuit for autonomous drug delivery in engineered tissues. Nims RJ, Pferdehirt L, Ho NB, Savadipour A, Lorentz J, Sohi S, Kassab J, Ross AK, O'Conor CJ, Liedtke WB, Zhang B, McNulty AL, Guilak F. Sci Adv. 2021 Jan 27;7(5). pii: 7/5/eabd9858. doi: 10.1126/sciadv.abd9858. Print 2021 Jan. PubMed |
| The IMiD target CRBN determines HSP90 activity toward transmembrane proteins essential in multiple myeloma. Heider M, Eichner R, Stroh J, Morath V, Kuisl A, Zecha J, Lawatscheck J, Baek K, Garz AK, Rudelius M, Deuschle FC, Keller U, Lemeer S, Verbeek M, Gotze KS, Skerra A, Weber WA, Buchner J, Schulman BA, Kuster B, Fernandez-Saiz V, Bassermann F. Mol Cell. 2021 Mar 18;81(6):1170-1186.e10. doi: 10.1016/j.molcel.2020.12.046. Epub 2021 Feb 10. PubMed |
| A genome-wide CRISPR screen identifies host factors that regulate SARS-CoV-2 entry. Zhu Y, Feng F, Hu G, Wang Y, Yu Y, Zhu Y, Xu W, Cai X, Sun Z, Han W, Ye R, Qu D, Ding Q, Huang X, Chen H, Xu W, Xie Y, Cai Q, Yuan Z, Zhang R. Nat Commun. 2021 Feb 11;12(1):961. doi: 10.1038/s41467-021-21213-4. PubMed |
| Two-component spike nanoparticle vaccine protects macaques from SARS-CoV-2 infection. Brouwer PJM, Brinkkemper M, Maisonnasse P, Dereuddre-Bosquet N, Grobben M, Claireaux M, de Gast M, Marlin R, Chesnais V, Diry S, Allen JD, Watanabe Y, Giezen JM, Kerster G, Turner HL, van der Straten K, van der Linden CA, Aldon Y, Naninck T, Bontjer I, Burger JA, Poniman M, Mykytyn AZ, Okba NMA, Schermer EE, van Breemen MJ, Ravichandran R, Caniels TG, van Schooten J, Kahlaoui N, Contreras V, Lemaitre J, Chapon C, Fang RHT, Villaudy J, Sliepen K, van der Velden YU, Haagmans BL, de Bree GJ, Ginoux E, Ward AB, Crispin M, King NP, van der Werf S, van Gils MJ, Le Grand R, Sanders RW. Cell. 2021 Mar 4;184(5):1188-1200.e19. doi: 10.1016/j.cell.2021.01.035. Epub 2021 Jan 26. PubMed |
The ubiquitin isopeptidase USP10 deubiquitinates LC3B to increase LC3B levels and autophagic activity.
Jia R, Bonifacino JS.
J Biol Chem. 2021 Jan-Jun;296:100405. doi: 10.1016/j.jbc.2021.100405. Epub 2021 Feb 10.
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Associated Plasmids |
| Signal peptidase complex subunit 1 is an essential Zika virus host factor in placental trophoblasts. Rother M, Naumann M. Virus Res. 2021 Apr 15;296:198338. doi: 10.1016/j.virusres.2021.198338. Epub 2021 Feb 9. PubMed |
| FGF8 and BMP2 mediated dynamic regulation of dental mesenchyme proliferation and differentiation via Lhx8/Suv39h1 complex. Zhou C, Chen D, Ren J, Huang D, Li R, Luo H, Guan C, Cao Y, Wang W. J Cell Mol Med. 2021 Mar;25(6):3051-3062. doi: 10.1111/jcmm.16351. Epub 2021 Feb 13. PubMed |
| Advanced single-cell pooled CRISPR screening identifies C19orf53 required for cell proliferation based on mTORC1 regulators. Tang Y, Liao S, Liu G, Xiong X, Liu H, Li F, Tan Z, Kong X, Yin Y, Tan B. Cell Biol Toxicol. 2021 Feb 13. pii: 10.1007/s10565-021-09586-0. doi: 10.1007/s10565-021-09586-0. PubMed |
| Lysophospholipid acylation modulates plasma membrane lipid organization and insulin sensitivity in skeletal muscle. Ferrara PJ, Rong X, Maschek JA, Verkerke AR, Siripoksup P, Song H, Green TD, Krishnan KC, Johnson JM, Turk J, Houmard JA, Lusis AJ, Drummond MJ, McClung JM, Cox JE, Shaikh SR, Tontonoz P, Holland WL, Funai K. J Clin Invest. 2021 Apr 15;131(8). pii: 135963. doi: 10.1172/JCI135963. PubMed |
| Centrosome amplification mediates small extracellular vesicle secretion via lysosome disruption. Adams SD, Csere J, D'angelo G, Carter EP, Romao M, Arnandis T, Dodel M, Kocher HM, Grose R, Raposo G, Mardakheh F, Godinho SA. Curr Biol. 2021 Apr 12;31(7):1403-1416.e7. doi: 10.1016/j.cub.2021.01.028. Epub 2021 Feb 15. PubMed |
| Modulating HSF1 levels impacts expression of the estrogen receptor alpha and antiestrogen response. Silveira MA, Tav C, Berube-Simard FA, Cuppens T, Leclercq M, Fournier E, Cote MC, Droit A, Bilodeau S. Life Sci Alliance. 2021 Feb 16;4(5). pii: 4/5/e202000811. doi: 10.26508/lsa.202000811. Print 2021 May. PubMed |
| Positioning of nucleosomes containing gamma-H2AX precedes active DNA demethylation and transcription initiation. Dobersch S, Rubio K, Singh I, Gunther S, Graumann J, Cordero J, Castillo-Negrete R, Huynh MB, Mehta A, Braubach P, Cabrera-Fuentes H, Bernhagen J, Chao CM, Bellusci S, Gunther A, Preissner KT, Kugel S, Dobreva G, Wygrecka M, Braun T, Papy-Garcia D, Barreto G. Nat Commun. 2021 Feb 16;12(1):1072. doi: 10.1038/s41467-021-21227-y. PubMed |
| Telomeres reforged with non-telomeric sequences in mouse embryonic stem cells. Kim C, Sung S, Kim JS, Lee H, Jung Y, Shin S, Kim E, Seo JJ, Kim J, Kim D, Niida H, Kim VN, Park D, Lee J. Nat Commun. 2021 Feb 17;12(1):1097. doi: 10.1038/s41467-021-21341-x. PubMed |
| The impact of episporic modification of Lichtheimia corymbifera on virulence and interaction with phagocytes. Hassan MIA, Keller M, Hillger M, Binder U, Reuter S, Herold K, Telagathoti A, Dahse HM, Wicht S, Trinks N, Nietzsche S, Deckert-Gaudig T, Deckert V, Mrowka R, Terpitz U, Peter Saluz H, Voigt K. Comput Struct Biotechnol J. 2021 Jan 20;19:880-896. doi: 10.1016/j.csbj.2021.01.023. eCollection 2021. PubMed |
| STIM2 Mediates Excessive Store-Operated Calcium Entry in Patient-Specific iPSC-Derived Neurons Modeling a Juvenile Form of Huntington's Disease. Vigont VA, Grekhnev DA, Lebedeva OS, Gusev KO, Volovikov EA, Skopin AY, Bogomazova AN, Shuvalova LD, Zubkova OA, Khomyakova EA, Glushankova LN, Klyushnikov SA, Illarioshkin SN, Lagarkova MA, Kaznacheyeva EV. Front Cell Dev Biol. 2021 Feb 2;9:625231. doi: 10.3389/fcell.2021.625231. eCollection 2021. PubMed |
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| SARS-CoV-2 and SARS-CoV Spike-Mediated Cell-Cell Fusion Differ in Their Requirements for Receptor Expression and Proteolytic Activation. Hornich BF, Grosskopf AK, Schlagowski S, Tenbusch M, Kleine-Weber H, Neipel F, Stahl-Hennig C, Hahn AS. J Virol. 2021 Apr 12;95(9). pii: JVI.00002-21. doi: 10.1128/JVI.00002-21. Print 2021 Apr 12. PubMed |
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Adenine Base Editor Ribonucleoproteins Delivered by Lentivirus-Like Particles Show High On-Target Base Editing and Undetectable RNA Off-Target Activities.
Lyu P, Lu Z, Cho SI, Yadav M, Yoo KW, Atala A, Kim JS, Lu B.
CRISPR J. 2021 Feb;4(1):69-81. doi: 10.1089/crispr.2020.0095.
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| Differentiated glioblastoma cells accelerate tumor progression by shaping the tumor microenvironment via CCN1-mediated macrophage infiltration. Uneda A, Kurozumi K, Fujimura A, Fujii K, Ishida J, Shimazu Y, Otani Y, Tomita Y, Hattori Y, Matsumoto Y, Tsuboi N, Makino K, Hirano S, Kamiya A, Date I. Acta Neuropathol Commun. 2021 Feb 22;9(1):29. doi: 10.1186/s40478-021-01124-7. PubMed |
| Silencing of SRRM4 suppresses microexon inclusion and promotes tumor growth across cancers. Head SA, Hernandez-Alias X, Yang JS, Ciampi L, Beltran-Sastre V, Torres-Mendez A, Irimia M, Schaefer MH, Serrano L. PLoS Biol. 2021 Feb 23;19(2):e3001138. doi: 10.1371/journal.pbio.3001138. eCollection 2021 Feb. PubMed |
| SEC24A facilitates colocalization and Ca(2) (+) flux between the endoplasmic reticulum and mitochondria. Chidawanyika T, Chakrabarti R, Beauchemin KS, Higgs HN, Supattapone S. J Cell Sci. 2021 Mar 26;134(6). pii: jcs.249276. doi: 10.1242/jcs.249276. PubMed |
| Control of ribosomal protein synthesis by the Microprocessor complex. Jiang X, Prabhakar A, Van der Voorn SM, Ghatpande P, Celona B, Venkataramanan S, Calviello L, Lin C, Wang W, Black BL, Floor SN, Lagna G, Hata A. Sci Signal. 2021 Feb 23;14(671). pii: 14/671/eabd2639. doi: 10.1126/scisignal.abd2639. PubMed |
| Acquired cancer cell resistance to T cell bispecific antibodies and CAR T targeting HER2 through JAK2 down-modulation. Arenas EJ, Martinez-Sabadell A, Rius Ruiz I, Roman Alonso M, Escorihuela M, Luque A, Fajardo CA, Gros A, Klein C, Arribas J. Nat Commun. 2021 Feb 23;12(1):1237. doi: 10.1038/s41467-021-21445-4. PubMed |
| Targeting EphA2 suppresses hepatocellular carcinoma initiation and progression by dual inhibition of JAK1/STAT3 and AKT signaling. Wang H, Hou W, Perera A, Bettler C, Beach JR, Ding X, Li J, Denning MF, Dhanarajan A, Cotler SJ, Joyce C, Yin J, Ahmed F, Roberts LR, Qiu W. Cell Rep. 2021 Feb 23;34(8):108765. doi: 10.1016/j.celrep.2021.108765. PubMed |
| Accelerating target deconvolution for therapeutic antibody candidates using highly parallelized genome editing. Mattsson J, Ekdahl L, Junghus F, Ajore R, Erlandsson E, Niroula A, Pertesi M, Frendeus B, Teige I, Nilsson B. Nat Commun. 2021 Feb 24;12(1):1277. doi: 10.1038/s41467-021-21518-4. PubMed |
| Combinatorial CRISPR screen identifies fitness effects of gene paralogues. Thompson NA, Ranzani M, van der Weyden L, Iyer V, Offord V, Droop A, Behan F, Goncalves E, Speak A, Iorio F, Hewinson J, Harle V, Robertson H, Anderson E, Fu B, Yang F, Zagnoli-Vieira G, Chapman P, Del Castillo Velasco-Herrera M, Garnett MJ, Jackson SP, Adams DJ. Nat Commun. 2021 Feb 26;12(1):1302. doi: 10.1038/s41467-021-21478-9. PubMed |
| Distinct genetic pathways define pre-malignant versus compensatory clonal hematopoiesis in Shwachman-Diamond syndrome. Kennedy AL, Myers KC, Bowman J, Gibson CJ, Camarda ND, Furutani E, Muscato GM, Klein RH, Ballotti K, Liu S, Harris CE, Galvin A, Malsch M, Dale D, Gansner JM, Nakano TA, Bertuch A, Vlachos A, Lipton JM, Castillo P, Connelly J, Churpek J, Edwards JR, Hijiya N, Ho RH, Hofmann I, Huang JN, Keel S, Lamble A, Lau BW, Norkin M, Stieglitz E, Stock W, Walkovich K, Boettcher S, Brendel C, Fleming MD, Davies SM, Weller EA, Bahl C, Carter SL, Shimamura A, Lindsley RC. Nat Commun. 2021 Feb 26;12(1):1334. doi: 10.1038/s41467-021-21588-4. PubMed |
| Open-Label Study of the Influence of Food Containing the Royal Sun Mushroom, Agaricus brasiliensis KA21 (Agaricomycetes), on beta-Glucan-Specific Antibody Production in Healthy Human Volunteers. Yamanaka D, Shoda M, Matsubara T, Ishibashi KI, Motoi A, Motoi R, Motoi M, Ohno N, Adachi Y. Int J Med Mushrooms. 2021;23(2):13-28. doi: 10.1615/IntJMedMushrooms.2020037471. PubMed |
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| ACE2 receptor usage reveals variation in susceptibility to SARS-CoV and SARS-CoV-2 infection among bat species. Yan H, Jiao H, Liu Q, Zhang Z, Xiong Q, Wang BJ, Wang X, Guo M, Wang LF, Lan K, Chen Y, Zhao H. Nat Ecol Evol. 2021 May;5(5):600-608. doi: 10.1038/s41559-021-01407-1. Epub 2021 Mar 1. PubMed |
| Plxdc family members are novel receptors for the rhesus monkey rhadinovirus (RRV). Grosskopf AK, Schlagowski S, Fricke T, Ensser A, Desrosiers RC, Hahn AS. PLoS Pathog. 2021 Mar 3;17(3):e1008979. doi: 10.1371/journal.ppat.1008979. eCollection 2021 Mar. PubMed |
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| Novel Secreted Protein of Mycoplasma bovis MbovP280 Induces Macrophage Apoptosis Through CRYAB. Zhao G, Zhu X, Zhang H, Chen Y, Schieck E, Hu C, Chen H, Guo A. Front Immunol. 2021 Feb 15;12:619362. doi: 10.3389/fimmu.2021.619362. eCollection 2021. PubMed |
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| C11orf95-RELA fusion drives aberrant gene expression through the unique epigenetic regulation for ependymoma formation. Ozawa T, Kaneko S, Szulzewsky F, Qiao Z, Takadera M, Narita Y, Kondo T, Holland EC, Hamamoto R, Ichimura K. Acta Neuropathol Commun. 2021 Mar 8;9(1):36. doi: 10.1186/s40478-021-01135-4. PubMed |
| Lin28 Inhibits the Differentiation from Mouse Embryonic Stem Cells to Glial Lineage Cells through Upregulation of Yap1. Luo J, Zou H, Deng L, Sun X, Yuan P, Li P. Stem Cells Int. 2021 Feb 22;2021:6674283. doi: 10.1155/2021/6674283. eCollection 2021. PubMed |
| Biofabrication of a three dimensional human-based personalized neurofibroma model. Roy V, Lamontagne R, Talagas M, Touzel-Deschenes L, Khuong HT, Saikali S, Dupre N, Gros-Louis F. Biotechnol J. 2021 Jun;16(6):e2000250. doi: 10.1002/biot.202000250. Epub 2021 Apr 7. PubMed |
| Identification of pathogenic variants in cancer genes using base editing screens with editing efficiency correction. Huang C, Li G, Wu J, Liang J, Wang X. Genome Biol. 2021 Mar 10;22(1):80. doi: 10.1186/s13059-021-02305-2. PubMed |
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| A novel cell culture system modeling the SARS-CoV-2 life cycle. Ju X, Zhu Y, Wang Y, Li J, Zhang J, Gong M, Ren W, Li S, Zhong J, Zhang L, Zhang QC, Zhang R, Ding Q. PLoS Pathog. 2021 Mar 12;17(3):e1009439. doi: 10.1371/journal.ppat.1009439. eCollection 2021 Mar. PubMed |
| Creb5 establishes the competence for Prg4 expression in articular cartilage. Zhang CH, Gao Y, Jadhav U, Hung HH, Holton KM, Grodzinsky AJ, Shivdasani RA, Lassar AB. Commun Biol. 2021 Mar 12;4(1):332. doi: 10.1038/s42003-021-01857-0. PubMed |
| FLI1 Induces Megakaryopoiesis Gene Expression Through WAS/WIP-Dependent and Independent Mechanisms; Implications for Wiskott-Aldrich Syndrome. Wang C, Sample KM, Gajendran B, Kapranov P, Liu W, Hu A, Zacksenhaus E, Li Y, Hao X, Ben-David Y. Front Immunol. 2021 Feb 26;12:607836. doi: 10.3389/fimmu.2021.607836. eCollection 2021. PubMed |
| Pin1 Promotes NLRP3 Inflammasome Activation by Phosphorylation of p38 MAPK Pathway in Septic Shock. Dong R, Xue Z, Fan G, Zhang N, Wang C, Li G, Da Y. Front Immunol. 2021 Feb 25;12:620238. doi: 10.3389/fimmu.2021.620238. eCollection 2021. PubMed |
| The Crucial Role of PPARgamma-Egr-1-Pro-Inflammatory Mediators Axis in IgG Immune Complex-Induced Acute Lung Injury. Yan C, Chen J, Ding Y, Zhou Z, Li B, Deng C, Yuan D, Zhang Q, Wang X. Front Immunol. 2021 Feb 25;12:634889. doi: 10.3389/fimmu.2021.634889. eCollection 2021. PubMed |
| Sall4 and Myocd Empower Direct Cardiac Reprogramming From Adult Cardiac Fibroblasts After Injury. Zhao H, Zhang Y, Xu X, Sun Q, Yang C, Wang H, Yang J, Yang Y, Yang X, Liu Y, Zhao Y. Front Cell Dev Biol. 2021 Feb 26;9:608367. doi: 10.3389/fcell.2021.608367. eCollection 2021. PubMed |
| Effective, safe, and sustained correction of murine XLA using a UCOE-BTK promoter-based lentiviral vector. Seymour BJ, Singh S, Certo HM, Sommer K, Sather BD, Khim S, Clough C, Hale M, Pangallo J, Ryu BY, Khan IF, Adair JE, Rawlings DJ. Mol Ther Methods Clin Dev. 2021 Jan 20;20:635-651. doi: 10.1016/j.omtm.2021.01.007. eCollection 2021 Mar 12. PubMed |
| Engineering T Cells to Express Tumoricidal MDA-7/IL24 Enhances Cancer Immunotherapy. Liu Z, Guo C, Das SK, Yu X, Pradhan AK, Li X, Ning Y, Chen S, Liu W, Windle JJ, Bear HD, Manjili MH, Fisher PB, Wang XY. Cancer Res. 2021 May 1;81(9):2429-2441. doi: 10.1158/0008-5472.CAN-20-2604. Epub 2021 Mar 16. PubMed |
| RNA decay in processing bodies is indispensable for adipogenesis. Maeda R, Kami D, Shikuma A, Suzuki Y, Taya T, Matoba S, Gojo S. Cell Death Dis. 2021 Mar 17;12(4):285. doi: 10.1038/s41419-021-03537-7. PubMed |
Lentiviral Capsid-Mediated Streptococcus pyogenes Cas9 Ribonucleoprotein Delivery for Efficient and Safe Multiplex Genome Editing.
Lu Z, Yao X, Lyu P, Yadav M, Yoo K, Atala A, Lu B.
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| CRISPRi screens reveal a DNA methylation-mediated 3D genome dependent causal mechanism in prostate cancer. Ahmed M, Soares F, Xia JH, Yang Y, Li J, Guo H, Su P, Tian Y, Lee HJ, Wang M, Akhtar N, Houlahan KE, Bosch A, Zhou S, Mazrooei P, Hua JT, Chen S, Petricca J, Zeng Y, Davies A, Fraser M, Quigley DA, Feng FY, Boutros PC, Lupien M, Zoubeidi A, Wang L, Walsh MJ, Wang T, Ren S, Wei GH, He HH. Nat Commun. 2021 Mar 19;12(1):1781. doi: 10.1038/s41467-021-21867-0. PubMed |
Engineered extracellular vesicles as versatile ribonucleoprotein delivery vehicles for efficient and safe CRISPR genome editing.
Yao X, Lyu P, Yoo K, Yadav MK, Singh R, Atala A, Lu B.
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| A hierarchical regulatory network analysis of the vitamin D induced transcriptome reveals novel regulators and complete VDR dependency in monocytes. Warwick T, Schulz MH, Gunther S, Gilsbach R, Neme A, Carlberg C, Brandes RP, Seuter S. Sci Rep. 2021 Mar 22;11(1):6518. doi: 10.1038/s41598-021-86032-5. PubMed |
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| Comparative analysis reveals the species-specific genetic determinants of ACE2 required for SARS-CoV-2 entry. Ren W, Zhu Y, Wang Y, Shi H, Yu Y, Hu G, Feng F, Zhao X, Lan J, Wu J, Kenney DJ, Douam F, Tong Y, Zhong J, Xie Y, Wang X, Yuan Z, Zhou D, Zhang R, Ding Q. PLoS Pathog. 2021 Mar 24;17(3):e1009392. doi: 10.1371/journal.ppat.1009392. eCollection 2021 Mar. PubMed |
| SH3BP4 promotes neuropilin-1 and alpha5-integrin endocytosis and is inhibited by Akt. Burckhardt CJ, Minna JD, Danuser G. Dev Cell. 2021 Apr 19;56(8):1164-1181.e12. doi: 10.1016/j.devcel.2021.03.009. Epub 2021 Mar 23. PubMed |
| HIF1alpha/HIF2alpha-Sox2/Klf4 promotes the malignant progression of glioblastoma via the EGFR-PI3K/AKT signalling pathway with positive feedback under hypoxia. Wang P, Zhao L, Gong S, Xiong S, Wang J, Zou D, Pan J, Deng Y, Yan Q, Wu N, Liao B. Cell Death Dis. 2021 Mar 24;12(4):312. doi: 10.1038/s41419-021-03598-8. PubMed |
WWTR1(TAZ)-CAMTA1 reprograms endothelial cells to drive epithelioid hemangioendothelioma.
Driskill JH, Zheng Y, Wu BK, Wang L, Cai J, Rakheja D, Dellinger M, Pan D.
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| A genome-scale CRISPR Cas9 dropout screen identifies synthetically lethal targets in SRC-3 inhibited cancer cells. Gilad Y, Eliaz Y, Yu Y, Dean AM, Han SJ, Qin L, O'Malley BW, Lonard DM. Commun Biol. 2021 Mar 25;4(1):399. doi: 10.1038/s42003-021-01929-1. PubMed |
| The tumor suppressor kinase DAPK3 drives tumor-intrinsic immunity through the STING-IFN-beta pathway. Takahashi M, Lio CJ, Campeau A, Steger M, Ay F, Mann M, Gonzalez DJ, Jain M, Sharma S. Nat Immunol. 2021 Apr;22(4):485-496. doi: 10.1038/s41590-021-00896-3. Epub 2021 Mar 25. PubMed |
| FEZ1 Forms Complexes with CRMP1 and DCC to Regulate Axon and Dendrite Development. Chua JY, Ng SJ, Yagensky O, Wanker EE, Chua JJE. eNeuro. 2021 Apr 16;8(2). pii: ENEURO.0193-20.2021. doi: 10.1523/ENEURO.0193-20.2021. Print 2021 Mar-Apr. PubMed |
| MED15 prion-like domain forms a coiled-coil responsible for its amyloid conversion and propagation. Batlle C, Calvo I, Iglesias V, J Lynch C, Gil-Garcia M, Serrano M, Ventura S. Commun Biol. 2021 Mar 26;4(1):414. doi: 10.1038/s42003-021-01930-8. PubMed |
| USP22 promotes melanoma and BRAF inhibitor resistance via YAP stabilization. Wei Y, Jiang Z, Lu J. Oncol Lett. 2021 May;21(5):394. doi: 10.3892/ol.2021.12655. Epub 2021 Mar 18. PubMed |
| A Role for Polo-Like Kinase 4 in Vascular Fibroblast Cell-Type Transition. Li J, Urabe G, Huang Y, Zhang M, Wang B, Marcho L, Shen H, Kent KC, Guo LW. JACC Basic Transl Sci. 2021 Mar 22;6(3):257-283. doi: 10.1016/j.jacbts.2020.12.015. eCollection 2021 Mar. PubMed |
| Sensitivity of cells to ATR and CHK1 inhibitors requires hyperactivation of CDK2 rather than endogenous replication stress or ATM dysfunction. Ditano JP, Donahue KL, Tafe LJ, McCleery CF, Eastman A. Sci Rep. 2021 Mar 29;11(1):7077. doi: 10.1038/s41598-021-86490-x. PubMed |
| A modified parachute assay for assessment of gap junction intercellular communication in placental trophoblast cells. Gingrich J, Pu Y, Veiga-Lopez A. Toxicol Mech Methods. 2021 Jun;31(5):393-399. doi: 10.1080/15376516.2021.1904072. Epub 2021 Mar 30. PubMed |
| RANK signaling increases after anti-HER2 therapy contributing to the emergence of resistance in HER2-positive breast cancer. Sanz-Moreno A, Palomeras S, Pedersen K, Morancho B, Pascual T, Galvan P, Benitez S, Gomez-Miragaya J, Ciscar M, Jimenez M, Pernas S, Petit A, Soler-Monso MT, Vinas G, Alsaleem M, Rakha EA, Green AR, Santamaria PG, Mulder C, Lemeer S, Arribas J, Prat A, Puig T, Gonzalez-Suarez E. Breast Cancer Res. 2021 Mar 30;23(1):42. doi: 10.1186/s13058-021-01390-2. PubMed |
| RIPK2 is an unfavorable prognosis marker and a potential therapeutic target in human kidney renal clear cell carcinoma. Li D, Tang L, Liu B, Xu S, Jin M, Bo W. Aging (Albany NY). 2021 Mar 31;13(7):10450-10467. doi: 10.18632/aging.202808. Epub 2021 Mar 31. PubMed |
| Control of endothelial quiescence by FOXO-regulated metabolites. Andrade J, Shi C, Costa ASH, Choi J, Kim J, Doddaballapur A, Sugino T, Ong YT, Castro M, Zimmermann B, Kaulich M, Guenther S, Wilhelm K, Kubota Y, Braun T, Koh GY, Grosso AR, Frezza C, Potente M. Nat Cell Biol. 2021 Apr;23(4):413-423. doi: 10.1038/s41556-021-00637-6. Epub 2021 Apr 1. PubMed |
| m(6)A-independent genome-wide METTL3 and METTL14 redistribution drives the senescence-associated secretory phenotype. Liu P, Li F, Lin J, Fukumoto T, Nacarelli T, Hao X, Kossenkov AV, Simon MC, Zhang R. Nat Cell Biol. 2021 Apr;23(4):355-365. doi: 10.1038/s41556-021-00656-3. Epub 2021 Apr 1. PubMed |
| Generation and Implementation of Reporter BHK-21 Cells for Live Imaging of Flavivirus Infection. Arias-Arias JL, Mora-Rodriguez R. Bio Protoc. 2021 Mar 5;11(5):e3942. doi: 10.21769/BioProtoc.3942. eCollection 2021 Mar 5. PubMed |
| Direct Generation of Immortalized Erythroid Progenitor Cell Lines from Peripheral Blood Mononuclear Cells. Bagchi A, Nath A, Thamodaran V, Ijee S, Palani D, Rajendiran V, Venkatesan V, Datari P, Pai AA, Janet NB, Balasubramanian P, Nakamura Y, Srivastava A, Mohankumar KM, Thangavel S, Velayudhan SR. Cells. 2021 Mar 1;10(3). pii: cells10030523. doi: 10.3390/cells10030523. PubMed |
| HIF-1alpha and Pro-Inflammatory Signaling Improves the Immunomodulatory Activity of MSC-Derived Extracellular Vesicles. Gomez-Ferrer M, Villanueva-Badenas E, Sanchez-Sanchez R, Sanchez-Lopez CM, Baquero MC, Sepulveda P, Dorronsoro A. Int J Mol Sci. 2021 Mar 26;22(7). pii: ijms22073416. doi: 10.3390/ijms22073416. PubMed |
| YTHDF1 Aggravates the Progression of Cervical Cancer Through m(6)A-Mediated Up-Regulation of RANBP2. Wang H, Luo Q, Kang J, Wei Q, Yang Y, Yang D, Liu X, Liu T, Yi P. Front Oncol. 2021 Mar 19;11:650383. doi: 10.3389/fonc.2021.650383. eCollection 2021. PubMed |
| Establishment and characterization of an immortalized epicardial cell line. Jiang H, Song S, Li J, Yin Q, Hu S, Nie Y. J Cell Mol Med. 2021 Apr 6. doi: 10.1111/jcmm.16496. PubMed |
| Gene Editing in Human Induced Pluripotent Stem Cells Using Doxycycline-Inducible CRISPR-Cas9 System. Thamodaran V, Rani S, Velayudhan SR. Methods Mol Biol. 2021 Apr 9. doi: 10.1007/7651_2021_348. PubMed |
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| Disruption of the MSL complex inhibits tumour maintenance by exacerbating chromosomal instability. Monserrat J, Morales Torres C, Richardson L, Wilson TS, Patel H, Domart MC, Horswell S, Song OR, Jiang M, Crawford M, Bui M, Dalal Y, Scaffidi P. Nat Cell Biol. 2021 Apr;23(4):401-412. doi: 10.1038/s41556-021-00657-2. Epub 2021 Apr 9. PubMed |
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Co-regulation and function of FOXM1/RHNO1 bidirectional genes in cancer.
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| PTEN is a predictive biomarker of trastuzumab resistance and prognostic factor in HER2-overexpressing gastroesophageal adenocarcinoma. Yokoyama D, Hisamori S, Deguchi Y, Nishigori T, Okabe H, Kanaya S, Manaka D, Kadokawa Y, Hata H, Minamiguchi S, Tsunoda S, Obama K, Sakai Y. Sci Rep. 2021 Apr 27;11(1):9013. doi: 10.1038/s41598-021-88331-3. PubMed |
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| PDZD8-mediated lipid transfer at contacts between the ER and late endosomes/lysosomes is required for neurite outgrowth. Gao Y, Xiong J, Chu QZ, Ji WK. J Cell Sci. 2022 Mar 1;135(5). pii: 256568. doi: 10.1242/jcs.255026. Epub 2021 Apr 20. PubMed |
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| Interpretative differences of combined cytogenetic and molecular profiling highlights differences between MRC and ELN classifications of AML. Sussman RT, Manning B, Ackerman D, Bigdeli A, Pammer P, Velu PD, Luger SM, Bagg A, Carroll M, Morrissette JJD. Cancer Genet. 2021 Aug;256-257:68-76. doi: 10.1016/j.cancergen.2021.04.004. Epub 2021 Apr 16. PubMed |
| Role of Decorin in Posterior Capsule Opacification and Eye Lens Development. Shibata S, Shibata N, Ohtsuka S, Yoshitomi Y, Kiyokawa E, Yonekura H, Singh DP, Sasaki H, Kubo E. Cells. 2021 Apr 9;10(4). pii: cells10040863. doi: 10.3390/cells10040863. PubMed |
| Selection, Expansion, and Unique Pretreatment of Allogeneic Human Natural Killer Cells with Anti-CD38 Monoclonal Antibody for Efficient Multiple Myeloma Treatment. Motais B, Charvatova S, Walek Z, Hrdinka M, Smolarczyk R, Cichon T, Czapla J, Giebel S, Simicek M, Jelinek T, Sevcikova T, Sobotka J, Koristek Z, Hajek R, Bago JR. Cells. 2021 Apr 21;10(5). pii: cells10050967. doi: 10.3390/cells10050967. PubMed |
| hTERT Downregulation Attenuates Resistance to DOX, Impairs FAK-Mediated Adhesion, and Leads to Autophagy Induction in Breast Cancer Cells. Romaniuk-Drapala A, Toton E, Konieczna N, Machnik M, Barczak W, Kowal D, Kopczynski P, Kaczmarek M, Rubis B. Cells. 2021 Apr 10;10(4). pii: cells10040867. doi: 10.3390/cells10040867. PubMed |
| Combination of Talazoparib and Palbociclib as a Potent Treatment Strategy in Bladder Cancer. Klein FG, Granier C, Zhao Y, Pan Q, Tong Z, Gschwend JE, Holm PS, Nawroth R. J Pers Med. 2021 Apr 24;11(5). pii: jpm11050340. doi: 10.3390/jpm11050340. PubMed |
| Live-Cell Analysis of Human Cytomegalovirus DNA Polymerase Holoenzyme Assembly by Resonance Energy Transfer Methods. Di Antonio V, Palu G, Alvisi G. Microorganisms. 2021 Apr 26;9(5). pii: microorganisms9050928. doi: 10.3390/microorganisms9050928. PubMed |
Profiling the genetic determinants of chromatin accessibility with scalable single-cell CRISPR screens.
Liscovitch-Brauer N, Montalbano A, Deng J, Mendez-Mancilla A, Wessels HH, Moss NG, Kung CY, Sookdeo A, Guo X, Geller E, Jaini S, Smibert P, Sanjana NE.
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| Cut-like homeobox 1 (CUX1) tumor suppressor gene haploinsufficiency induces apoptosis evasion to sustain myeloid leukemia. Supper E, Rudat S, Iyer V, Droop A, Wong K, Spinella JF, Thomas P, Sauvageau G, Adams DJ, Wong CC. Nat Commun. 2021 Apr 30;12(1):2482. doi: 10.1038/s41467-021-22750-8. PubMed |
| Multiple interactions of the oncoprotein transcription factor MYC with the SWI/SNF chromatin remodeler. Woodley CM, Romer AS, Wang J, Guarnaccia AD, Elion DL, Maxwell JN, Guerrazzi K, McCann TS, Popay TM, Matlock BK, Flaherty DK, Lorey SL, Liu Q, Tansey WP, Weissmiller AM. Oncogene. 2021 May;40(20):3593-3609. doi: 10.1038/s41388-021-01804-7. Epub 2021 Apr 30. PubMed |
| HIF1alpha-dependent induction of the mitochondrial chaperone TRAP1 regulates bioenergetic adaptations to hypoxia. Laquatra C, Sanchez-Martin C, Dinarello A, Cannino G, Minervini G, Moroni E, Schiavone M, Tosatto S, Argenton F, Colombo G, Bernardi P, Masgras I, Rasola A. Cell Death Dis. 2021 May 1;12(5):434. doi: 10.1038/s41419-021-03716-6. PubMed |
| Quantitative proteomic analysis of extracellular vesicle subgroups isolated by an optimized method combining polymer-based precipitation and size exclusion chromatography. Martinez-Greene JA, Hernandez-Ortega K, Quiroz-Baez R, Resendis-Antonio O, Pichardo-Casas I, Sinclair DA, Budnik B, Hidalgo-Miranda A, Uribe-Querol E, Ramos-Godinez MDP, Martinez-Martinez E. J Extracell Vesicles. 2021 Apr;10(6):e12087. doi: 10.1002/jev2.12087. Epub 2021 Apr 27. PubMed |
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| Reversible switching of primary cells between normal and malignant state by oncogenic virus KSHV and CRISPR/Cas9-mediated targeting of a major viral latent protein. Ju E, Li T, Ramos da Silva S, Markazi A, Gao SJ. J Med Virol. 2021 Aug;93(8):5065-5075. doi: 10.1002/jmv.27046. Epub 2021 May 3. PubMed |
| The Zinc Finger Antiviral Protein ZAP Restricts Human Cytomegalovirus and Selectively Binds and Destabilizes Viral UL4/UL5 Transcripts. Gonzalez-Perez AC, Stempel M, Wyler E, Urban C, Piras A, Hennig T, Ganskih S, Wei Y, Heim A, Landthaler M, Pichlmair A, Dolken L, Munschauer M, Erhard F, Brinkmann MM. mBio. 2021 May 4;12(3). pii: mBio.02683-20. doi: 10.1128/mBio.02683-20. PubMed |
| Structure of the full-length human Pannexin1 channel and insights into its role in pyroptosis. Zhang S, Yuan B, Lam JH, Zhou J, Zhou X, Ramos-Mandujano G, Tian X, Liu Y, Han R, Li Y, Gao X, Li M, Yang M. Cell Discov. 2021 May 4;7(1):30. doi: 10.1038/s41421-021-00259-0. PubMed |
| SAM homeostasis is regulated by CFIm-mediated splicing of MAT2A. Scarborough AM, Flaherty JN, Hunter OV, Liu K, Kumar A, Xing C, Tu BP, Conrad NK. Elife. 2021 May 5;10. pii: 64930. doi: 10.7554/eLife.64930. PubMed |
| NFIB induces functional astrocytes from human pluripotent stem cell-derived neural precursor cells mimicking in vivo astrogliogenesis. Yeon GB, Shin WH, Yoo SH, Kim D, Jeon BM, Park WU, Bae Y, Park JY, You S, Na D, Kim DS. J Cell Physiol. 2021 May 5. doi: 10.1002/jcp.30405. PubMed |
| High-Level Production of Recombinant Eukaryotic Proteins from Mammalian Cells Using Lentivirus. Behiels E, Elegheert J. Methods Mol Biol. 2021;2305:83-104. doi: 10.1007/978-1-0716-1406-8_4. PubMed |
| Cohesin-protein Shugoshin-1 controls cardiac automaticity via HCN4 pacemaker channel. Liu D, Song AT, Qi X, van Vliet PP, Xiao J, Xiong F, Andelfinger G, Nattel S. Nat Commun. 2021 May 5;12(1):2551. doi: 10.1038/s41467-021-22737-5. PubMed |
| Minimized combinatorial CRISPR screens identify genetic interactions in autophagy. Diehl V, Wegner M, Grumati P, Husnjak K, Schaubeck S, Gubas A, Shah VJ, Polat IH, Langschied F, Prieto-Garcia C, Muller K, Kalousi A, Ebersberger I, Brandts CH, Dikic I, Kaulich M. Nucleic Acids Res. 2021 Jun 4;49(10):5684-5704. doi: 10.1093/nar/gkab309. PubMed |
| MyD88 oligomer size functions as a physical threshold to trigger IL1R Myddosome signaling. Deliz-Aguirre R, Cao F, Gerpott FHU, Auevechanichkul N, Chupanova M, Mun Y, Ziska E, Taylor MJ. J Cell Biol. 2021 Jul 5;220(7). pii: 212080. doi: 10.1083/jcb.202012071. Epub 2021 May 6. PubMed |
| Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains. Piette BL, Alerasool N, Lin ZY, Lacoste J, Lam MHY, Qian WW, Tran S, Larsen B, Campos E, Peng J, Gingras AC, Taipale M. Mol Cell. 2021 Jun 17;81(12):2549-2565.e8. doi: 10.1016/j.molcel.2021.04.012. Epub 2021 May 5. PubMed |
| Targeting non-canonical activation of GLI1 by the SOX2-BRD4 transcriptional complex improves the efficacy of HEDGEHOG pathway inhibition in melanoma. Pietrobono S, Gaudio E, Gagliardi S, Zitani M, Carrassa L, Migliorini F, Petricci E, Manetti F, Makukhin N, Bond AG, Paradise BD, Ciulli A, Fernandez-Zapico ME, Bertoni F, Stecca B. Oncogene. 2021 Jun;40(22):3799-3814. doi: 10.1038/s41388-021-01783-9. Epub 2021 May 6. PubMed |
| Membrane protein regulators of melanoma pulmonary colonisation identified using a CRISPRa screen and spontaneous metastasis assay in mice. van der Weyden L, Offord V, Turner G, Swiatkowska A, Speak AO, Adams DJ. G3 (Bethesda). 2021 May 7. pii: 6272227. doi: 10.1093/g3journal/jkab157. PubMed |
| Marker-free quantification of repair pathway utilization at Cas9-induced double-strand breaks. Feng W, Simpson DA, Cho JE, Carvajal-Garcia J, Smith CM, Headley KM, Hathaway N, Ramsden DA, Gupta GP. Nucleic Acids Res. 2021 May 21;49(9):5095-5105. doi: 10.1093/nar/gkab299. PubMed |
| A Validated Functional Analysis of Partner and Localizer of BRCA2 Missense Variants for Use in Clinical Variant Interpretation. Brnich SE, Arteaga EC, Wang Y, Tan X, Berg JS. J Mol Diagn. 2021 Jul;23(7):847-864. doi: 10.1016/j.jmoldx.2021.04.010. Epub 2021 May 6. PubMed |
| Coiled-Coil Domain-Containing 68 Downregulation Promotes Colorectal Cancer Cell Growth by Inhibiting ITCH-Mediated CDK4 Degradation. Wang C, Li H, Wu L, Jiao X, Jin Z, Zhu Y, Fang Z, Zhang X, Huang H, Zhao L. Front Oncol. 2021 Apr 22;11:668743. doi: 10.3389/fonc.2021.668743. eCollection 2021. PubMed |
| Effects of Amyloid Precursor Protein Overexpression on NF-kappaB, Rho-GTPase and Pro-Apoptosis Bcl-2 Pathways in Neuronal Cells. Chan HH, Leong YQ, Voon SM, Pan ML, Leong CO, Lim CL, Koh RY. Rep Biochem Mol Biol. 2021 Jan;9(4):417-425. doi: 10.52547/rbmb.9.4.417. PubMed |
| In vivo CRISPR screening for novel noncoding RNA functional targets in glioblastoma models. Attenello FJ, Tsung K, Bishara I, Loh YE, Chen TC. J Neurosci Res. 2021 Sep;99(9):2029-2045. doi: 10.1002/jnr.24850. Epub 2021 May 10. PubMed |
| Smac mimetics and TRAIL cooperate to induce MLKL-dependent necroptosis in Burkitt's lymphoma cell lines. Koch A, Jeiler B, Roedig J, van Wijk SJL, Dolgikh N, Fulda S. Neoplasia. 2021 May;23(5):539-550. doi: 10.1016/j.neo.2021.03.003. Epub 2021 May 7. PubMed |
| Cell-surface SLC nucleoside transporters and purine levels modulate BRD4-dependent chromatin states. Li KC, Girardi E, Kartnig F, Grosche S, Pemovska T, Bigenzahn JW, Goldmann U, Sedlyarov V, Bensimon A, Schick S, Lin JG, Gurtl B, Reil D, Klavins K, Kubicek S, Sdelci S, Superti-Furga G. Nat Metab. 2021 May;3(5):651-664. doi: 10.1038/s42255-021-00386-8. Epub 2021 May 10. PubMed |
| Identification of poly(ADP-ribose) polymerase 9 (PARP9) as a noncanonical sensor for RNA virus in dendritic cells. Xing J, Zhang A, Du Y, Fang M, Minze LJ, Liu YJ, Li XC, Zhang Z. Nat Commun. 2021 May 11;12(1):2681. doi: 10.1038/s41467-021-23003-4. PubMed |
| Probing RAS Function with Monobodies. Khan I, O'Bryan JP. Methods Mol Biol. 2021;2262:281-302. doi: 10.1007/978-1-0716-1190-6_17. PubMed |
| Delete_A Facile Method to Engineer Mutant Kras Alleles in an Isogenic Cell Background. Budagyan K, Chernoff J. Methods Mol Biol. 2021;2262:323-334. doi: 10.1007/978-1-0716-1190-6_20. PubMed |
| RIPK1 is a negative mediator in Aquaporin 1-driven triple-negative breast carcinoma progression and metastasis. Yin Z, Chen W, Yin J, Sun J, Xie Q, Wu M, Zeng F, Ren H. NPJ Breast Cancer. 2021 May 12;7(1):53. doi: 10.1038/s41523-021-00261-5. PubMed |
| Structural basis for broad coronavirus neutralization. Sauer MM, Tortorici MA, Park YJ, Walls AC, Homad L, Acton OJ, Bowen JE, Wang C, Xiong X, de van der Schueren W, Quispe J, Hoffstrom BG, Bosch BJ, McGuire AT, Veesler D. Nat Struct Mol Biol. 2021 Jun;28(6):478-486. doi: 10.1038/s41594-021-00596-4. Epub 2021 May 12. PubMed |
| SOX9-induced Generation of Functional Astrocytes Supporting Neuronal Maturation in an All-human System. Neyrinck K, Van Den Daele J, Vervliet T, De Smedt J, Wierda K, Nijs M, Vanbokhoven T, D'hondt A, Planque M, Fendt SM, Shih PY, Seibt F, Almenar JP, Kreir M, Kumar D, Broccoli V, Bultynck G, Ebneth A, Cabrera-Socorro A, Verfaillie C. Stem Cell Rev Rep. 2021 May 12. pii: 10.1007/s12015-021-10179-x. doi: 10.1007/s12015-021-10179-x. PubMed |
| Hyperbaric oxygen promotes not only glioblastoma proliferation but also chemosensitization by inhibiting HIF1alpha/HIF2alpha-Sox2. Wang P, Gong S, Pan J, Wang J, Zou D, Xiong S, Zhao L, Yan Q, Deng Y, Wu N, Liao B. Cell Death Discov. 2021 May 13;7(1):103. doi: 10.1038/s41420-021-00486-0. PubMed |
| Differentiation-related zinc finger protein 750 suppresses cell growth in esophageal squamous cell carcinoma. Ana Choi SS, Ko JM, Yu VZ, Ning L, Lung ML. Oncol Lett. 2021 Jul;22(1):513. doi: 10.3892/ol.2021.12774. Epub 2021 May 5. PubMed |
Quantifying persistence in the T-cell signaling network using an optically controllable antigen receptor.
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| Rab34 GTPase mediates ciliary membrane formation in the intracellular ciliogenesis pathway. Ganga AK, Kennedy MC, Oguchi ME, Gray S, Oliver KE, Knight TA, De La Cruz EM, Homma Y, Fukuda M, Breslow DK. Curr Biol. 2021 Jul 12;31(13):2895-2905.e7. doi: 10.1016/j.cub.2021.04.075. Epub 2021 May 13. PubMed |
| Loss of the WNT9a ligand aggravates the rheumatoid arthritis-like symptoms in hTNF transgenic mice. Teufel S, Kockemann P, Fabritius C, Wolff LI, Bertrand J, Pap T, Hartmann C. Cell Death Dis. 2021 May 15;12(5):494. doi: 10.1038/s41419-021-03786-6. PubMed |
| G-protein coupled receptor 35 (GPR35) regulates the colonic epithelial cell response to enterotoxigenic Bacteroides fragilis. Boleij A, Fathi P, Dalton W, Park B, Wu X, Huso D, Allen J, Besharati S, Anders RA, Housseau F, Mackenzie AE, Jenkins L, Milligan G, Wu S, Sears CL. Commun Biol. 2021 May 14;4(1):585. doi: 10.1038/s42003-021-02014-3. PubMed |
| Single AAV-mediated CRISPR-Nme2Cas9 efficiently reduces mutant hTTR expression in a transgenic mouse model of transthyretin amyloidosis. Wen J, Cao T, Wu J, Chen Y, Zhi S, Huang Y, Zhen P, Wu G, Aagaard L, Zhong J, Liang P, Huang J. Mol Ther. 2022 Jan 5;30(1):164-174. doi: 10.1016/j.ymthe.2021.05.010. Epub 2021 May 14. PubMed |
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| Mutagenesis of Human Cytomegalovirus Glycoprotein L Disproportionately Disrupts gH/gL/gO over gH/gL/pUL128-131. Schultz EP, Yu Q, Stegmann C, Day LZ, Lanchy JM, Ryckman BJ. J Virol. 2021 Aug 10;95(17):e0061221. doi: 10.1128/JVI.00612-21. Epub 2021 Aug 10. PubMed |
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| The pan-cancer lncRNA PLANE regulates an alternative splicing program to promote cancer pathogenesis. Teng L, Feng YC, Guo ST, Wang PL, Qi TF, Yue YM, Wang SX, Zhang SN, Tang CX, La T, Zhang YY, Zhao XH, Gao JN, Wei LY, Zhang D, Wang JY, Shi Y, Liu XY, Li JM, Cao H, Liu T, Thorne RF, Jin L, Shao FM, Zhang XD. Nat Commun. 2021 Jun 18;12(1):3734. doi: 10.1038/s41467-021-24099-4. PubMed |
| Mist1 Inhibits Epithelial-Mesenchymal Transition in Gastric Adenocarcinoma via Downregulating the Wnt/beta-catenin Pathway. Xie X, Zhou Z, Song Y, Zhang X, Dang C, Zhang H. J Cancer. 2021 Jun 1;12(15):4574-4584. doi: 10.7150/jca.59138. eCollection 2021. PubMed |
| Role of the transcriptional regulator SP140 in resistance to bacterial infections via repression of type I interferons. Ji DX, Witt KC, Kotov DI, Margolis SR, Louie A, Chevee V, Chen KJ, Gaidt MM, Dhaliwal HS, Lee AY, Nishimura SL, Zamboni DS, Kramnik I, Portnoy DA, Darwin KH, Vance RE. Elife. 2021 Jun 21;10. pii: 67290. doi: 10.7554/eLife.67290. PubMed |
| BECN2 (beclin 2) Negatively Regulates Inflammasome Sensors Through ATG9A-Dependent but ATG16L1- and LC3-Independent Non-Canonical Autophagy. Deng G, Li C, Chen L, Xing C, Fu C, Qian C, Liu X, Wang HY, Zhu M, Wang RF. Autophagy. 2022 Feb;18(2):340-356. doi: 10.1080/15548627.2021.1934270. Epub 2021 Jun 21. PubMed |
| Aberrant activation of Rho/ROCK signaling in impaired polarity switching of colorectal micropapillary carcinoma. Onuma K, Sato Y, Okuyama H, Uematsu H, Homma K, Ohue M, Kondo J, Inoue M. J Pathol. 2021 Sep;255(1):84-94. doi: 10.1002/path.5748. Epub 2021 Jul 16. PubMed |
| Upregulation of the ErbB family by EZH2 in hepatocellular carcinoma confers resistance to FGFR inhibitor. Prawira A, Le TBU, Ho RZW, Huynh H. J Cancer Res Clin Oncol. 2021 Oct;147(10):2955-2968. doi: 10.1007/s00432-021-03703-6. Epub 2021 Jun 22. PubMed |
| The MLKL kinase-like domain dimerization is an indispensable step of mammalian MLKL activation in necroptosis signaling. Zhang Y, Liu J, Yu D, Zhu X, Liu X, Liao J, Li S, Wang H. Cell Death Dis. 2021 Jun 22;12(7):638. doi: 10.1038/s41419-021-03859-6. PubMed |
| CRISPR Interference (CRISPRi) and CRISPR Activation (CRISPRa) to Explore the Oncogenic lncRNA Network. Morelli E, Gulla' A, Amodio N, Taiana E, Neri A, Fulciniti M, Munshi NC. Methods Mol Biol. 2021;2348:189-204. doi: 10.1007/978-1-0716-1581-2_13. PubMed |
Positive feedback between the T cell kinase Zap70 and its substrate LAT acts as a clustering-dependent signaling switch.
Dine E, Reed EH, Toettcher JE.
Cell Rep. 2021 Jun 22;35(12):109280. doi: 10.1016/j.celrep.2021.109280.
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| DDB1 binds histone reader BRWD3 to activate the transcriptional cascade in adipogenesis and promote onset of obesity. Wang X, Wang HY, Hu GS, Tang WS, Weng L, Zhang Y, Guo H, Yao SS, Liu SY, Zhang GL, Han Y, Liu M, Zhang XD, Cen X, Shen HF, Xiao N, Liu CQ, Wang HR, Huang J, Liu W, Li P, Zhao TJ. Cell Rep. 2021 Jun 22;35(12):109281. doi: 10.1016/j.celrep.2021.109281. PubMed |
| Reduced PHLPP Expression Leads to EGFR-TKI Resistance in Lung Cancer by Activating PI3K-AKT and MAPK-ERK Dual Signaling. Wang W, Xia X, Chen K, Chen M, Meng Y, Lv D, Yang H. Front Oncol. 2021 Jun 8;11:665045. doi: 10.3389/fonc.2021.665045. eCollection 2021. PubMed |
| CHK1 inhibitor sensitizes resistant colorectal cancer stem cells to nortopsentin. Di Franco S, Parrino B, Gaggianesi M, Pantina VD, Bianca P, Nicotra A, Mangiapane LR, Lo Iacono M, Ganduscio G, Veschi V, Brancato OR, Glaviano A, Turdo A, Pillitteri I, Colarossi L, Cascioferro S, Carbone D, Pecoraro C, Fiori ME, De Maria R, Todaro M, Screpanti I, Cirrincione G, Diana P, Stassi G. iScience. 2021 May 29;24(6):102664. doi: 10.1016/j.isci.2021.102664. eCollection 2021 Jun 25. PubMed |
| Protocol to establish a lung adenocarcinoma immunotherapy allograft mouse model with FACS and immunofluorescence-based analysis of tumor response. Peng Z, Yu M, Lin J, Dong T, Zhang X, Shi M, Qin M, Li S, Guo W, Zhang H, Sun S. STAR Protoc. 2021 Jun 11;2(2):100595. doi: 10.1016/j.xpro.2021.100595. eCollection 2021 Jun 18. PubMed |
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| BAP1/ASXL complex modulation regulates epithelial-mesenchymal transition during trophoblast differentiation and invasion. Perez-Garcia V, Lea G, Lopez-Jimenez P, Okkenhaug H, Burton GJ, Moffett A, Turco MY, Hemberger M. Elife. 2021 Jun 25;10. pii: 63254. doi: 10.7554/eLife.63254. PubMed |
| Heparan Sulfate Facilitates Spike Protein-Mediated SARS-CoV-2 Host Cell Invasion and Contributes to Increased Infection of SARS-CoV-2 G614 Mutant and in Lung Cancer. Yue J, Jin W, Yang H, Faulkner J, Song X, Qiu H, Teng M, Azadi P, Zhang F, Linhardt RJ, Wang L. Front Mol Biosci. 2021 Jun 11;8:649575. doi: 10.3389/fmolb.2021.649575. eCollection 2021. PubMed |
| A flow cytometry-based assay for serological detection of anti-spike antibodies in COVID-19 patients. Goh YS, Ng LFP, Renia L. STAR Protoc. 2021 Sep 17;2(3):100671. doi: 10.1016/j.xpro.2021.100671. Epub 2021 Jun 19. PubMed |
| Low-Density Lipoprotein Receptor-Related Protein 6 Cell Surface Availability Regulates Fuel Metabolism in Astrocytes. Chow HM, Sun JK, Hart RP, Cheng KK, Hung CHL, Lau TM, Kwan KM. Adv Sci (Weinh). 2021 Aug;8(16):e2004993. doi: 10.1002/advs.202004993. Epub 2021 Jun 27. PubMed |
| Analysis of SAMHD1 Restriction by Flow Cytometry in Human Myeloid U937 Cells. Ordonez P, Bishop KN, Stoye JP, Groom HCT. J Vis Exp. 2021 Jun 13;(172). doi: 10.3791/62502. PubMed |
| The endogenous cellular protease inhibitor SPINT2 controls SARS-CoV-2 viral infection and is associated to disease severity. Ramirez Alvarez C, Kee C, Sharma AK, Thomas L, Schmidt FI, Stanifer ML, Boulant S, Herrmann C. PLoS Pathog. 2021 Jun 28;17(6):e1009687. doi: 10.1371/journal.ppat.1009687. eCollection 2021 Jun. PubMed |
Epitranscriptomic editing of the RNA N6-methyladenosine modification by dCasRx conjugated methyltransferase and demethylase.
Xia Z, Tang M, Ma J, Zhang H, Gimple RC, Prager BC, Tang H, Sun C, Liu F, Lin P, Mei Y, Du R, Rich JN, Xie Q.
Nucleic Acids Res. 2021 Jul 21;49(13):7361-7374. doi: 10.1093/nar/gkab517.
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| The long non-coding RNA betaFaar regulates islet beta-cell function and survival during obesity in mice. Zhang F, Yang Y, Chen X, Liu Y, Hu Q, Huang B, Liu Y, Pan Y, Zhang Y, Liu D, Liang R, Li G, Wei Q, Li L, Jin L. Nat Commun. 2021 Jun 28;12(1):3997. doi: 10.1038/s41467-021-24302-6. PubMed |
| Targeting Pyruvate Kinase M2 Phosphorylation Reverses Aggressive Cancer Phenotypes. Apostolidi M, Vathiotis IA, Muthusamy V, Gaule P, Gassaway BM, Rimm DL, Rinehart J. Cancer Res. 2021 Aug 15;81(16):4346-4359. doi: 10.1158/0008-5472.CAN-20-4190. Epub 2021 Jun 21. PubMed |
| Osmotic pressure modulates single cell cycle dynamics inducing reversible growth arrest and reactivation of human metastatic cells. Taieb HM, Garske DS, Contzen J, Gossen M, Bertinetti L, Robinson T, Cipitria A. Sci Rep. 2021 Jun 29;11(1):13455. doi: 10.1038/s41598-021-92054-w. PubMed |
| A T cell redirection platform for co-targeting dual antigens on solid tumors. Enderle L, Shalaby KH, Gorelik M, Weiss A, Blazer LL, Paduch M, Cardarelli L, Kossiakoff A, Adams JJ, Sidhu SS. MAbs. 2021 Jan-Dec;13(1):1933690. doi: 10.1080/19420862.2021.1933690. PubMed |
| Zika Virus Hijacks Extracellular Vesicle Tetraspanin Pathways for Cell-to-Cell Transmission. York SB, Sun L, Cone AS, Duke LC, Cheerathodi MR, Meckes DG Jr. mSphere. 2021 Jun 30:e0019221. doi: 10.1128/mSphere.00192-21. PubMed |
| Breast tumor stiffness instructs bone metastasis via maintenance of mechanical conditioning. Watson AW, Grant AD, Parker SS, Hill S, Whalen MB, Chakrabarti J, Harman MW, Roman MR, Forte BL, Gowan CC, Castro-Portuguez R, Stolze LK, Franck C, Cusanovich DA, Zavros Y, Padi M, Romanoski CE, Mouneimne G. Cell Rep. 2021 Jun 29;35(13):109293. doi: 10.1016/j.celrep.2021.109293. PubMed |
| Revealing molecular pathways for cancer cell fitness through a genetic screen of the cancer translatome. Kuzuoglu-Ozturk D, Hu Z, Rama M, Devericks E, Weiss J, Chiang GG, Worland ST, Brenner SE, Goodarzi H, Gilbert LA, Ruggero D. Cell Rep. 2021 Jun 29;35(13):109321. doi: 10.1016/j.celrep.2021.109321. PubMed |
| Shape of promoter antisense RNAs regulates ligand-induced transcription activation. Yang F, Tanasa B, Micheletti R, Ohgi KA, Aggarwal AK, Rosenfeld MG. Nature. 2021 Jul;595(7867):444-449. doi: 10.1038/s41586-021-03589-x. Epub 2021 Jun 30. PubMed |
| NADH Fluorescence Lifetime Imaging Microscopy Reveals Selective Mitochondrial Dysfunction in Neurons Overexpressing Alzheimer's Disease-Related Proteins. Niederschweiberer MA, Schaefer PM, Singh LN, Lausser L, Bhosale D, Hesse R, Calzia E, Kestler HA, Rueck A, Wallace DC, von Einem B, von Arnim CAF. Front Mol Biosci. 2021 Jun 14;8:671274. doi: 10.3389/fmolb.2021.671274. eCollection 2021. PubMed |
| CAR T cells targeting tumor-associated exons of glypican 2 regress neuroblastoma in mice. Li N, Torres MB, Spetz MR, Wang R, Peng L, Tian M, Dower CM, Nguyen R, Sun M, Tai CH, de Val N, Cachau R, Wu X, Hewitt SM, Kaplan RN, Khan J, St Croix B, Thiele CJ, Ho M. Cell Rep Med. 2021 Jun 1;2(6):100297. doi: 10.1016/j.xcrm.2021.100297. eCollection 2021 Jun 15. PubMed |
| How Cancer Cells Invade Bladder Epithelium and Form Tumors: The Mouse Bladder Tumor Model as a Model of Tumor Recurrence in Patients. Erman A, Kamensek U, Dragin Jerman U, Pavlin M, Cemazar M, Veranic P, Romih R. Int J Mol Sci. 2021 Jun 13;22(12). pii: ijms22126328. doi: 10.3390/ijms22126328. PubMed |
| Microtubule Acetylation Controls MDA-MB-231 Breast Cancer Cell Invasion through the Modulation of Endoplasmic Reticulum Stress. Ko P, Choi JH, Song S, Keum S, Jeong J, Hwang YE, Kim JW, Rhee S. Int J Mol Sci. 2021 Jun 2;22(11). pii: ijms22116018. doi: 10.3390/ijms22116018. PubMed |
| Overexpression of Replication-Dependent Histone Signifies a Subset of Dedifferentiated Liposarcoma with Increased Aggressiveness. Yoo Y, Park SY, Jo EB, Choi M, Lee KW, Hong D, Lee S, Lee CR, Lee Y, Um JY, Park JB, Seo SW, Choi YL, Kim S, Lee SG, Choi M. Cancers (Basel). 2021 Jun 22;13(13). pii: cancers13133122. doi: 10.3390/cancers13133122. PubMed |
| Concurrent mutations in RNA-dependent RNA polymerase and spike protein emerged as the epidemiologically most successful SARS-CoV-2 variant. Ilmjarv S, Abdul F, Acosta-Gutierrez S, Estarellas C, Galdadas I, Casimir M, Alessandrini M, Gervasio FL, Krause KH. Sci Rep. 2021 Jul 1;11(1):13705. doi: 10.1038/s41598-021-91662-w. PubMed |
| The RNA sensor MDA5 detects SARS-CoV-2 infection. Sampaio NG, Chauveau L, Hertzog J, Bridgeman A, Fowler G, Moonen JP, Dupont M, Russell RA, Noerenberg M, Rehwinkel J. Sci Rep. 2021 Jul 1;11(1):13638. doi: 10.1038/s41598-021-92940-3. PubMed |
| Acidic pH irreversibly activates the signaling enzyme SARM1. Zhao YJ, He WM, Zhao ZY, Li WH, Wang QW, Hou YN, Tan Y, Zhang D. FEBS J. 2021 Jul 2. doi: 10.1111/febs.16104. PubMed |
| Systematic analysis of SARS-CoV-2 infection of an ACE2-negative human airway cell. Puray-Chavez M, LaPak KM, Schrank TP, Elliott JL, Bhatt DP, Agajanian MJ, Jasuja R, Lawson DQ, Davis K, Rothlauf PW, Liu Z, Jo H, Lee N, Tenneti K, Eschbach JE, Shema Mugisha C, Cousins EM, Cloer EW, Vuong HR, VanBlargan LA, Bailey AL, Gilchuk P, Crowe JE Jr, Diamond MS, Hayes DN, Whelan SPJ, Horani A, Brody SL, Goldfarb D, Major MB, Kutluay SB. Cell Rep. 2021 Jul 13;36(2):109364. doi: 10.1016/j.celrep.2021.109364. Epub 2021 Jun 23. PubMed |
| Non-Structural Protein 5 of Zika Virus Interacts with p53 in Human Neural Progenitor Cells and Induces p53-Mediated Apoptosis. Li P, Jiang H, Peng H, Zeng W, Zhong Y, He M, Xie L, Chen J, Guo D, Wu J, Li CM. Virol Sin. 2021 Jul 5. pii: 10.1007/s12250-021-00422-7. doi: 10.1007/s12250-021-00422-7. PubMed |
| The proteolytic landscape of cells exposed to non-lethal stresses is shaped by executioner caspases. Conde-Rubio MDC, Mylonas R, Widmann C. Cell Death Discov. 2021 Jun 19;7(1):164. doi: 10.1038/s41420-021-00539-4. PubMed |
| Generation of CAR-T Cells by Lentiviral Transduction. Okuma A. Methods Mol Biol. 2021;2312:3-14. doi: 10.1007/978-1-0716-1441-9_1. PubMed |
| Active elimination of intestinal cells drives oncogenic growth in organoids. Krotenberg Garcia A, Fumagalli A, Le HQ, Jackstadt R, Lannagan TRM, Sansom OJ, van Rheenen J, Suijkerbuijk SJE. Cell Rep. 2021 Jul 6;36(1):109307. doi: 10.1016/j.celrep.2021.109307. PubMed |
| Regulation of NMDA receptor trafficking and gating by activity-dependent CaMKIIalpha phosphorylation of the GluN2A subunit. Yong XLH, Zhang L, Yang L, Chen X, Tan JZA, Yu X, Chandra M, Livingstone E, Widagdo J, Vieira MM, Roche KW, Lynch JW, Keramidas A, Collins BM, Anggono V. Cell Rep. 2021 Jul 6;36(1):109338. doi: 10.1016/j.celrep.2021.109338. PubMed |
| The Mediator subunit MED20 organizes the early adipogenic complex to promote development of adipose tissues and diet-induced obesity. Tang WS, Weng L, Wang X, Liu CQ, Hu GS, Yin ST, Tao Y, Hong NN, Guo H, Liu W, Wang HR, Zhao TJ. Cell Rep. 2021 Jul 6;36(1):109314. doi: 10.1016/j.celrep.2021.109314. PubMed |
| The site of breast cancer metastases dictates their clonal composition and reversible transcriptomic profile. Berthelet J, Wimmer VC, Whitfield HJ, Serrano A, Boudier T, Mangiola S, Merdas M, El-Saafin F, Baloyan D, Wilcox J, Wilcox S, Parslow AC, Papenfuss AT, Yeo B, Ernst M, Pal B, Anderson RL, Davis MJ, Rogers KL, Hollande F, Merino D. Sci Adv. 2021 Jul 7;7(28). pii: 7/28/eabf4408. doi: 10.1126/sciadv.abf4408. Print 2021 Jul. PubMed |
| Prognostic role and biologic features of Musashi-2 expression in colon polyps and during colorectal cancer progression. Kharin L, Bychkov I, Karnaukhov N, Voloshin M, Fazliyeva R, Deneka A, Frantsiyants E, Kit O, Golemis E, Boumber Y. PLoS One. 2021 Jul 8;16(7):e0252132. doi: 10.1371/journal.pone.0252132. eCollection 2021. PubMed |
| The multi-functional reovirus sigma3 protein is a virulence factor that suppresses stress granule formation and is associated with myocardial injury. Guo Y, Hinchman MM, Lewandrowski M, Cross ST, Sutherland DM, Welsh OL, Dermody TS, Parker JSL. PLoS Pathog. 2021 Jul 8;17(7):e1009494. doi: 10.1371/journal.ppat.1009494. eCollection 2021 Jul. PubMed |
| The RAS GTPase RIT1 compromises mitotic fidelity through spindle assembly checkpoint suppression. Cuevas-Navarro A, Van R, Cheng A, Urisman A, Castel P, McCormick F. Curr Biol. 2021 Sep 13;31(17):3915-3924.e9. doi: 10.1016/j.cub.2021.06.030. Epub 2021 Jul 7. PubMed |
| PIAS1 potentiates the anti-EBV activity of SAMHD1 through SUMOylation. Saiada F, Zhang K, Li R. Cell Biosci. 2021 Jul 8;11(1):127. doi: 10.1186/s13578-021-00636-y. PubMed |
| lncRNA GAU1 Induces GALNT8 Overexpression and Potentiates Colorectal Cancer Progression. Tang X, Ruan H, Dong L, Li S, Wu Z, Guan M. Gastroenterol Res Pract. 2021 Jun 17;2021:5960821. doi: 10.1155/2021/5960821. eCollection 2021. PubMed |
| ARHGEF26 enhances Salmonella invasion and inflammation in cells and mice. Bourgeois JS, Wang L, Rabino AF, Everitt J, Alvarez MI, Awadia S, Wittchen ES, Garcia-Mata R, Ko DC. PLoS Pathog. 2021 Jul 9;17(7):e1009713. doi: 10.1371/journal.ppat.1009713. eCollection 2021 Jul. PubMed |
| The fluid shear stress sensor TRPM7 regulates tumor cell intravasation. Yankaskas CL, Bera K, Stoletov K, Serra SA, Carrillo-Garcia J, Tuntithavornwat S, Mistriotis P, Lewis JD, Valverde MA, Konstantopoulos K. Sci Adv. 2021 Jul 9;7(28). pii: 7/28/eabh3457. doi: 10.1126/sciadv.abh3457. Print 2021 Jul. PubMed |
| Cholesterol auxotrophy as a targetable vulnerability in clear cell renal cell carcinoma. Riscal R, Bull CJ, Mesaros C, Finan JM, Carens M, Ho ES, Xu JP, Godfrey J, Brennan P, Johansson M, Purdue MP, Chanock SJ, Mariosa D, Timpson NJ, Vincent EE, Keith B, Blair IA, Skuli N, Simon MC. Cancer Discov. 2021 Jul 8. pii: 2159-8290.CD-21-0211. doi: 10.1158/2159-8290.CD-21-0211. PubMed |
| TMEM97 ablation aggravates oxidant-induced retinal degeneration. Shen H, Li J, Heisler-Taylor T, Makin R, Yang H, Mavlyutov TA, Gelfand B, Cebulla CM, Guo LW. Cell Signal. 2021 Oct;86:110078. doi: 10.1016/j.cellsig.2021.110078. Epub 2021 Jul 7. PubMed |
| Single-Cell Analyses Reveal Diverse Mechanisms of Resistance to EGFR Tyrosine Kinase Inhibitors in Lung Cancer. Kashima Y, Shibahara D, Suzuki A, Muto K, Kobayashi IS, Plotnick D, Udagawa H, Izumi H, Shibata Y, Tanaka K, Fujii M, Ohashi A, Seki M, Goto K, Tsuchihara K, Suzuki Y, Kobayashi SS. Cancer Res. 2021 Sep 15;81(18):4835-4848. doi: 10.1158/0008-5472.CAN-20-2811. Epub 2021 Jul 9. PubMed |
| CD3G or CD3D Knockdown in Mature, but Not Immature, T Lymphocytes Similarly Cripples the Human TCRalphabeta Complex. Garcillan B, Fuentes P, Marin AV, Megino RF, Chacon-Arguedas D, Mazariegos MS, Jimenez-Reinoso A, Munoz-Ruiz M, Laborda RG, Cardenas PP, Fernandez-Malave E, Toribio ML, Regueiro JR. Front Cell Dev Biol. 2021 Jun 25;9:608490. doi: 10.3389/fcell.2021.608490. eCollection 2021. PubMed |
| MicroRNA-324-5p-CUEDC2 Axis Mediates Gain-of-Function Mutant p53-Driven Cancer Stemness. Ghatak D, Datta A, Roychowdhury T, Chattopadhyay S, Roychoudhury S. Mol Cancer Res. 2021 Jul 13. pii: 1541-7786.MCR-20-0717. doi: 10.1158/1541-7786.MCR-20-0717. PubMed |
| circFAT1 Promotes Cancer Stemness and Immune Evasion by Promoting STAT3 Activation. Jia L, Wang Y, Wang CY. Adv Sci (Weinh). 2021 May 2;8(13):2003376. doi: 10.1002/advs.202003376. eCollection 2021 Jul. PubMed |
| Advancing a rapid, high throughput screening platform for optimization of lentivirus production. Gopal S, Osborne AE, Hock L, Zemianek J, Fang K, Gee G, Ghosh R, McNally D, Cramer SM, Dordick JS. Biotechnol J. 2021 Jul 14:e2000621. doi: 10.1002/biot.202000621. PubMed |
| The long noncoding RNA HOTAIRM1 controlled by AML1 enhances glucocorticoid resistance by activating RHOA/ROCK1 pathway through suppressing ARHGAP18. Liang L, Gu W, Li M, Gao R, Zhang X, Guo C, Mi S. Cell Death Dis. 2021 Jul 14;12(7):702. doi: 10.1038/s41419-021-03982-4. PubMed |
| Large parental differences in chromatin organization in pancreatic beta cell line explaining diabetes susceptibility effects. Jian X, Felsenfeld G. Nat Commun. 2021 Jul 15;12(1):4338. doi: 10.1038/s41467-021-24635-2. PubMed |
| Squalene epoxidase promotes colorectal cancer cell proliferation through accumulating calcitriol and activating CYP24A1-mediated MAPK signaling. He L, Li H, Pan C, Hua Y, Peng J, Zhou Z, Zhao Y, Lin M. Cancer Commun (Lond). 2021 Aug;41(8):726-746. doi: 10.1002/cac2.12187. Epub 2021 Jul 16. PubMed |
Mutants of human ACE2 differentially promote SARS-CoV and SARS-CoV-2 spike mediated infection.
Shukla N, Roelle SM, Suzart VG, Bruchez AM, Matreyek KA.
PLoS Pathog. 2021 Jul 16;17(7):e1009715. doi: 10.1371/journal.ppat.1009715. eCollection 2021 Jul.
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| Glycerol-3-phosphate biosynthesis regenerates cytosolic NAD(+) to alleviate mitochondrial disease. Liu S, Fu S, Wang G, Cao Y, Li L, Li X, Yang J, Li N, Shan Y, Cao Y, Ma Y, Dong M, Liu Q, Jiang H. Cell Metab. 2021 Jul 8. pii: S1550-4131(21)00283-7. doi: 10.1016/j.cmet.2021.06.013. PubMed |
| Mutation in FBXO32 causes dilated cardiomyopathy through up-regulation of ER-stress mediated apoptosis. Al-Yacoub N, Colak D, Mahmoud SA, Hammonds M, Muhammed K, Al-Harazi O, Assiri AM, Al-Buraiki J, Al-Habeeb W, Poizat C. Commun Biol. 2021 Jul 16;4(1):884. doi: 10.1038/s42003-021-02391-9. PubMed |
| Astragaloside IV ameliorates diabetic nephropathy in db/db mice by inhibiting NLRP3 inflammasomemediated inflammation. Feng H, Zhu X, Tang Y, Fu S, Kong B, Liu X. Int J Mol Med. 2021 Aug;48(2). pii: 164. doi: 10.3892/ijmm.2021.4996. Epub 2021 Jul 19. PubMed |
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| TRAF6 Promoted Tumor Glycolysis in Non-Small-Cell Lung Cancer by Activating the Akt-HIFalpha Pathway. Feng L, Feng S, Nie Z, Deng Y, Xuan Y, Chen X, Lu Y, Liang L, Chen Y. Biomed Res Int. 2021 Aug 6;2021:3431245. doi: 10.1155/2021/3431245. eCollection 2021. PubMed |
| Aging-Associated Differences in Epitranscriptomic m6A Regulation in Response to Acute Cardiac Ischemia/Reperfusion Injury in Female Mice. Su X, Shen Y, Jin Y, Kim IM, Weintraub NL, Tang Y. Front Pharmacol. 2021 Aug 3;12:654316. doi: 10.3389/fphar.2021.654316. eCollection 2021. PubMed |
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| TDO2 Was Downregulated in Hepatocellular Carcinoma and Inhibited Cell Proliferation by Upregulating the Expression of p21 and p27. Yu C, Rao D, Zhu H, Liu Q, Huang W, Zhang L, Liang H, Song J, Ding Z. Biomed Res Int. 2021 Aug 13;2021:4708439. doi: 10.1155/2021/4708439. eCollection 2021. PubMed |
| Caspases Switch off the m(6)A RNA Modification Pathway to Foster the Replication of a Ubiquitous Human Tumor Virus. Zhang K, Zhang Y, Maharjan Y, Sugiokto FG, Wan J, Li R. mBio. 2021 Aug 31;12(4):e0170621. doi: 10.1128/mBio.01706-21. Epub 2021 Aug 24. PubMed |
| Genome-wide CRISPR activation screen identifies candidate receptors for SARS-CoV-2 entry. Zhu S, Liu Y, Zhou Z, Zhang Z, Xiao X, Liu Z, Chen A, Dong X, Tian F, Chen S, Xu Y, Wang C, Li Q, Niu X, Pan Q, Du S, Xiao J, Wang J, Wei W. Sci China Life Sci. 2022 Apr;65(4):701-717. doi: 10.1007/s11427-021-1990-5. Epub 2021 Aug 20. PubMed |
| RUSC2 and WDR47 oppositely regulate kinesin-1-dependent distribution of ATG9A to the cell periphery. Guardia CM, Jain A, Mattera R, Friefeld A, Li Y, Bonifacino JS. Mol Biol Cell. 2021 Nov 1;32(21):ar25. doi: 10.1091/mbc.E21-06-0295. Epub 2021 Aug 25. PubMed |
| Downregulation of Hotair or LSD1 Impaired Heart Regeneration in the Neonatal Mouse. Fei Q, Qiu M, Fan G, Zhang B, Wang Q, Zhang S, Wang S, Yang B, Zhang L. DNA Cell Biol. 2021 Sep;40(9):1177-1184. doi: 10.1089/dna.2021.0095. Epub 2021 Aug 24. PubMed |
| Gain-of-function p53(R172H) mutation drives accumulation of neutrophils in pancreatic tumors, promoting resistance to immunotherapy. Siolas D, Vucic E, Kurz E, Hajdu C, Bar-Sagi D. Cell Rep. 2021 Aug 24;36(8):109578. doi: 10.1016/j.celrep.2021.109578. PubMed |
NKD2 mediates stimulation-dependent ORAI1 trafficking to augment Ca(2+) entry in T cells.
Wu B, Woo JS, Vila P, Jew M, Leung J, Sun Z, Srikanth S, Gwack Y.
Cell Rep. 2021 Aug 24;36(8):109603. doi: 10.1016/j.celrep.2021.109603.
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| Functional genomics atlas of synovial fibroblasts defining rheumatoid arthritis heritability. Ge X, Frank-Bertoncelj M, Klein K, McGovern A, Kuret T, Houtman M, Burja B, Micheroli R, Shi C, Marks M, Filer A, Buckley CD, Orozco G, Distler O, Morris AP, Martin P, Eyre S, Ospelt C. Genome Biol. 2021 Aug 25;22(1):247. doi: 10.1186/s13059-021-02460-6. PubMed |
| Quantification of microRNA editing using two-tailed RT-qPCR for improved biomarker discovery. Voss G, Edsjo A, Bjartell A, Ceder Y. RNA. 2021 Nov;27(11):1412-1424. doi: 10.1261/rna.078867.121. Epub 2021 Aug 25. PubMed |
| NDST3 deacetylates alpha-tubulin and suppresses V-ATPase assembly and lysosomal acidification. Tang Q, Liu M, Liu Y, Hwang RD, Zhang T, Wang J. EMBO J. 2021 Oct 1;40(19):e107204. doi: 10.15252/embj.2020107204. Epub 2021 Aug 25. PubMed |
| Phosphatidylserine binding directly regulates TIM-3 function. Smith CM, Li A, Krishnamurthy N, Lemmon MA. Biochem J. 2021 Sep 17;478(17):3331-3349. doi: 10.1042/BCJ20210425. PubMed |
| Disruption of RING and PHD Domains of TRIM28 Evokes Differentiation in Human iPSCs. Mazurek S, Oleksiewicz U, Czerwinska P, Wroblewska J, Klimczak M, Wiznerowicz M. Cells. 2021 Jul 29;10(8). pii: cells10081933. doi: 10.3390/cells10081933. PubMed |
Application of prime editing to the correction of mutations and phenotypes in adult mice with liver and eye diseases.
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Nat Biomed Eng. 2021 Aug 26. pii: 10.1038/s41551-021-00788-9. doi: 10.1038/s41551-021-00788-9.
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Direct observation of aggregate-triggered selective autophagy in human cells.
Janssen AFJ, Korsten G, Nijenhuis W, Katrukha EA, Kapitein LC.
J Cell Sci. 2021 Oct 1;134(19). pii: 271972. doi: 10.1242/jcs.258824. Epub 2021 Oct 6.
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| Nanog, in Cooperation with AP1, Increases the Expression of E6/E7 Oncogenes from HPV Types 16/18. Diaz-Tejeda Y, Guido-Jimenez MC, Lopez-Carbajal H, Amador-Molina A, Mendez-Martinez R, Gariglio-Vidal P, Lizano M, Garcia-Carranca A. Viruses. 2021 Jul 28;13(8). pii: v13081482. doi: 10.3390/v13081482. PubMed |
| A Genome-Wide CRISPR/Cas9 Screen Reveals the Requirement of Host Sphingomyelin Synthase 1 for Infection with Pseudorabies Virus Mutant gD(-)Pass. Holper JE, Grey F, Baillie JK, Regan T, Parkinson NJ, Hoper D, Thamamongood T, Schwemmle M, Pannhorst K, Wendt L, Mettenleiter TC, Klupp BG. Viruses. 2021 Aug 9;13(8). pii: v13081574. doi: 10.3390/v13081574. PubMed |
| A Novel Frameshifting Inhibitor Having Antiviral Activity against Zoonotic Coronaviruses. Ahn DG, Yoon GY, Lee S, Ku KB, Kim C, Kim KD, Kwon YC, Kim GW, Kim BT, Kim SJ. Viruses. 2021 Aug 18;13(8). pii: v13081639. doi: 10.3390/v13081639. PubMed |
| Uncovering cancer vulnerabilities by machine learning prediction of synthetic lethality. Benfatto S, Sercin O, Dejure FR, Abdollahi A, Zenke FT, Mardin BR. Mol Cancer. 2021 Aug 28;20(1):111. doi: 10.1186/s12943-021-01405-8. PubMed |
| miR-200c-141 Enhances Sheep Kidney Cell Reprogramming into Pluripotent Cells by Targeting ZEB1. Zhang Y, He Y, Wu P, Hu S, Zhang Y, Chen C. Int J Stem Cells. 2021 Nov 30;14(4):423-433. doi: 10.15283/ijsc21080. PubMed |
| Angiopoietin-like 3 inhibition of endothelial lipase is not modulated by angiopoietin-like 8. Sylvers-Davie KL, Segura-Roman A, Salvi AM, Schache KJ, Davies BSJ. J Lipid Res. 2021;62:100112. doi: 10.1016/j.jlr.2021.100112. Epub 2021 Aug 27. PubMed |
| Targeting the Atf7ip-Setdb1 Complex Augments Antitumor Immunity by Boosting Tumor Immunogenicity. Hu H, Khodadadi-Jamayran A, Dolgalev I, Cho H, Badri S, Chiriboga LA, Zeck B, Lopez De Rodas Gregorio M, Dowling CM, Labbe K, Deng J, Chen T, Zhang H, Zappile P, Chen Z, Ueberheide B, Karatza A, Han H, Ranieri M, Tang S, Jour G, Osman I, Sucker A, Schadendorf D, Tsirigos A, Schalper KA, Velcheti V, Huang HY, Jin Y, Ji H, Poirier JT, Li F, Wong KK. Cancer Immunol Res. 2021 Nov;9(11):1298-1315. doi: 10.1158/2326-6066.CIR-21-0543. Epub 2021 Aug 30. PubMed |
| The Smac mimetic BV6 cooperates with STING to induce necroptosis in apoptosis-resistant pancreatic carcinoma cells. Hannes S, Karlowitz R, van Wijk SJL. Cell Death Dis. 2021 Aug 30;12(9):816. doi: 10.1038/s41419-021-04014-x. PubMed |
| Hypoxia-inducible factor 1-alpha enhances the secretome to rejuvenate adult cardiosphere-derived cells. Saha P, Kim M, Tulshyan A, Guo Y, Mishra R, Li D, Civin CI, Kaushal S, Sharma S. J Thorac Cardiovasc Surg. 2021 Jul 17. pii: S0022-5223(21)01046-1. doi: 10.1016/j.jtcvs.2021.07.015. PubMed |
| Antibody-Drug Conjugate Efficacy in Neuroblastoma: Role of Payload, Resistance Mechanisms, Target Density, and Antibody Internalization. Buongervino S, Lane MV, Garrigan E, Zhelev DV, Dimitrov DS, Bosse KR. Mol Cancer Ther. 2021 Nov;20(11):2228-2239. doi: 10.1158/1535-7163.MCT-20-1034. Epub 2021 Aug 31. PubMed |
| Acquisition of aneuploidy drives mutant p53-associated gain-of-function phenotypes. Redman-Rivera LN, Shaver TM, Jin H, Marshall CB, Schafer JM, Sheng Q, Hongo RA, Beckermann KE, Wheeler FC, Lehmann BD, Pietenpol JA. Nat Commun. 2021 Aug 31;12(1):5184. doi: 10.1038/s41467-021-25359-z. PubMed |
| Targeted T cell receptor gene editing provides predictable T cell product function for immunotherapy. Muller TR, Jarosch S, Hammel M, Leube J, Grassmann S, Bernard B, Effenberger M, Andra I, Chaudhry MZ, Kauferle T, Malo A, Cicin-Sain L, Steinberger P, Feuchtinger T, Protzer U, Schumann K, Neuenhahn M, Schober K, Busch DH. Cell Rep Med. 2021 Aug 17;2(8):100374. doi: 10.1016/j.xcrm.2021.100374. eCollection 2021 Aug 17. PubMed |
| Targeted disruption of GAK stagnates autophagic flux by disturbing lysosomal dynamics. Miyazaki M, Hiramoto M, Takano N, Kokuba H, Takemura J, Tokuhisa M, Hino H, Kazama H, Miyazawa K. Int J Mol Med. 2021 Oct;48(4). pii: 195. doi: 10.3892/ijmm.2021.5028. Epub 2021 Sep 1. PubMed |
| A NSD3-targeted PROTAC suppresses NSD3 and cMyc oncogenic nodes in cancer cells. Xu C, Meng F, Park KS, Storey AJ, Gong W, Tsai YH, Gibson E, Byrum SD, Li D, Edmondson RD, Mackintosh SG, Vedadi M, Cai L, Tackett AJ, Kaniskan HU, Jin J, Wang GG. Cell Chem Biol. 2022 Mar 17;29(3):386-397.e9. doi: 10.1016/j.chembiol.2021.08.004. Epub 2021 Aug 31. PubMed |
| Iron loading induces cholesterol synthesis and sensitizes endothelial cells to TNFalpha-mediated apoptosis. Fisher AL, Srole DN, Palaskas NJ, Meriwether D, Reddy ST, Ganz T, Nemeth E. J Biol Chem. 2021 Oct;297(4):101156. doi: 10.1016/j.jbc.2021.101156. Epub 2021 Sep 2. PubMed |
| Targeting the IRE1alpha/XBP1s pathway suppresses CARM1-expressing ovarian cancer. Lin J, Liu H, Fukumoto T, Zundell J, Yan Q, Tang CA, Wu S, Zhou W, Guo D, Karakashev S, Hu CA, Sarma K, Kossenkov AV, Zhang R. Nat Commun. 2021 Sep 7;12(1):5321. doi: 10.1038/s41467-021-25684-3. PubMed |
| Photoreceptor nanotubes mediate the in vivo exchange of intracellular material. Ortin-Martinez A, Yan NE, Tsai ELS, Comanita L, Gurdita A, Tachibana N, Liu ZC, Lu S, Dolati P, Pokrajac NT, El-Sehemy A, Nickerson PEB, Schuurmans C, Bremner R, Wallace VA. EMBO J. 2021 Nov 15;40(22):e107264. doi: 10.15252/embj.2020107264. Epub 2021 Sep 8. PubMed |
| Cytosolic delivery of CDK4/6 inhibitor p16 protein using engineered protein crystals for cancer therapy. Yang Z, Yang M, Chow HM, Tsang SY, Lee MM, Chan MK. Acta Biomater. 2021 Nov;135:582-592. doi: 10.1016/j.actbio.2021.08.054. Epub 2021 Sep 5. PubMed |
| ZFP36L2 Role in Thyroid Functionality. Albano F, Tucci V, Blackshear PJ, Reale C, Roberto L, Russo F, Marotta P, Porreca I, Colella M, Mallardo M, de Felice M, Ambrosino C. Int J Mol Sci. 2021 Aug 29;22(17). pii: ijms22179379. doi: 10.3390/ijms22179379. PubMed |
| SHP2 as a Potential Therapeutic Target in Diffuse-Type Gastric Carcinoma Addicted to Receptor Tyrosine Kinase Signaling. Nagamura Y, Miyazaki M, Nagano Y, Tomiyama A, Ohki R, Yanagihara K, Sakai R, Yamaguchi H. Cancers (Basel). 2021 Aug 26;13(17). pii: cancers13174309. doi: 10.3390/cancers13174309. PubMed |
| Downregulation of KLF4 activates embryonic and fetal globin mRNA expression in human erythroid progenitor cells. Khamphikham P, Jearawiriyapaisarn N, Tangprasittipap A, Hongeng S. Exp Ther Med. 2021 Oct;22(4):1105. doi: 10.3892/etm.2021.10539. Epub 2021 Aug 2. PubMed |
| Regulation and role of glycophagy in skeletal muscle energy metabolism. Heden TD, Chow LS, Hughey CC, Mashek DG. Autophagy. 2021 Sep 10:1-12. doi: 10.1080/15548627.2021.1969633. PubMed |
| Viral Manipulation of a Mechanoresponsive Signaling Axis Disassembles Processing Bodies. Castle EL, Robinson CA, Douglas P, Rinker KD, Corcoran JA. Mol Cell Biol. 2021 Oct 26;41(11):e0039921. doi: 10.1128/MCB.00399-21. Epub 2021 Sep 13. PubMed |
| Host phospholipid peroxidation fuels ExoU-dependent cell necrosis and supports Pseudomonas aeruginosa-driven pathology. Bagayoko S, Leon-Icaza SA, Pinilla M, Hessel A, Santoni K, Pericat D, Bordignon PJ, Moreau F, Eren E, Boyance A, Naser E, Lefevre L, Berrone C, Iakobachvili N, Metais A, Rombouts Y, Lugo-Villarino G, Coste A, Attree I, Frank DW, Clevers H, Peters PJ, Cougoule C, Planes R, Meunier E. PLoS Pathog. 2021 Sep 13;17(9):e1009927. doi: 10.1371/journal.ppat.1009927. eCollection 2021 Sep. PubMed |
| Mutagenicity Profile Induced by UVB Light in Human Xeroderma Pigmentosum Group C Cells(dagger). Quintero-Ruiz N, Corradi C, Moreno NC, de Souza TA, Pereira Castro L, Rocha CRR, Menck CFM. Photochem Photobiol. 2021 Sep 13. doi: 10.1111/php.13516. PubMed |
| Virus-induced senescence is a driver and therapeutic target in COVID-19. Lee S, Yu Y, Trimpert J, Benthani F, Mairhofer M, Richter-Pechanska P, Wyler E, Belenki D, Kaltenbrunner S, Pammer M, Kausche L, Firsching TC, Dietert K, Schotsaert M, Martinez-Romero C, Singh G, Kunz S, Niemeyer D, Ghanem R, Salzer HJF, Paar C, Mulleder M, Uccellini M, Michaelis EG, Khan A, Lau A, Schonlein M, Habringer A, Tomasits J, Adler JM, Kimeswenger S, Gruber AD, Hoetzenecker W, Steinkellner H, Purfurst B, Motz R, Di Pierro F, Lamprecht B, Osterrieder N, Landthaler M, Drosten C, Garcia-Sastre A, Langer R, Ralser M, Eils R, Reimann M, Fan DNY, Schmitt CA. Nature. 2021 Nov;599(7884):283-289. doi: 10.1038/s41586-021-03995-1. Epub 2021 Sep 13. PubMed |
| MEF2D-NR4A1-FAM134B2-mediated reticulophagy contributes to amino acid homeostasis. Shiozaki Y, Miyazaki-Anzai S, Keenan AL, Miyazaki M. Autophagy. 2021 Sep 14:1-13. doi: 10.1080/15548627.2021.1968228. PubMed |
| Therapeutic inhibition of USP9x-mediated Notch signaling in triple-negative breast cancer. Jaiswal A, Murakami K, Elia A, Shibahara Y, Done SJ, Wood SA, Donato NJ, Ohashi PS, Reedijk M. Proc Natl Acad Sci U S A. 2021 Sep 21;118(38). pii: 2101592118. doi: 10.1073/pnas.2101592118. PubMed |
Intrinsically disordered protein biosensor tracks the physical-chemical effects of osmotic stress on cells.
Cuevas-Velazquez CL, Vellosillo T, Guadalupe K, Schmidt HB, Yu F, Moses D, Brophy JAN, Cosio-Acosta D, Das A, Wang L, Jones AM, Covarrubias AA, Sukenik S, Dinneny JR.
Nat Commun. 2021 Sep 14;12(1):5438. doi: 10.1038/s41467-021-25736-8.
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| An active tethering mechanism controls the fate of vesicles. An SJ, Rivera-Molina F, Anneken A, Xi Z, McNellis B, Polejaev VI, Toomre D. Nat Commun. 2021 Sep 14;12(1):5434. doi: 10.1038/s41467-021-25465-y. PubMed |
| Therapeutic targeting of the PLK1-PRC1-axis triggers cell death in genomically silent childhood cancer. Li J, Ohmura S, Marchetto A, Orth MF, Imle R, Dallmayer M, Musa J, Knott MML, Holting TLB, Stein S, Funk CM, Sastre A, Alonso J, Bestvater F, Kasan M, Romero-Perez L, Hartmann W, Ranft A, Banito A, Dirksen U, Kirchner T, Cidre-Aranaz F, Grunewald TGP. Nat Commun. 2021 Sep 16;12(1):5356. doi: 10.1038/s41467-021-25553-z. PubMed |
| Generation of stable cell lines using readthrough expression from lentiviral integration. Jadav A, Truong K. Biotechnol Lett. 2021 Nov;43(11):2131-2136. doi: 10.1007/s10529-021-03186-y. Epub 2021 Sep 17. PubMed |
| Critical Evaluation of Different Lysosomal Labeling Methods Used to Analyze RNA Nanocarrier Trafficking in Cells. Iqbal S, Luo B, Melamed JR, Day ES. Bioconjug Chem. 2021 Oct 20;32(10):2245-2256. doi: 10.1021/acs.bioconjchem.1c00405. Epub 2021 Sep 20. PubMed |
| PCV2 targets cGAS to inhibit type I interferon induction to promote other DNA virus infection. Wang Z, Chen J, Wu X, Ma D, Zhang X, Li R, Han C, Liu H, Yin X, Du Q, Tong D, Huang Y. PLoS Pathog. 2021 Sep 20;17(9):e1009940. doi: 10.1371/journal.ppat.1009940. eCollection 2021 Sep. PubMed |
| ATF4-mediated transcriptional regulation protects against beta-cell loss during endoplasmic reticulum stress in a mouse model. Kitakaze K, Oyadomari M, Zhang J, Hamada Y, Takenouchi Y, Tsuboi K, Inagaki M, Tachikawa M, Fujitani Y, Okamoto Y, Oyadomari S. Mol Metab. 2021 Dec;54:101338. doi: 10.1016/j.molmet.2021.101338. Epub 2021 Sep 20. PubMed |
| Epicardial differentiation drives fibro-fatty remodeling in arrhythmogenic cardiomyopathy. Kohela A, van Kampen SJ, Moens T, Wehrens M, Molenaar B, Boogerd CJ, Monshouwer-Kloots J, Perini I, Goumans MJ, Smits AM, van Tintelen JP, van Rooij E. Sci Transl Med. 2021 Sep 22;13(612):eabf2750. doi: 10.1126/scitranslmed.abf2750. Epub 2021 Sep 22. PubMed |
| Liquid condensation of reprogramming factor KLF4 with DNA provides a mechanism for chromatin organization. Sharma R, Choi KJ, Quan MD, Sharma S, Sankaran B, Park H, LaGrone A, Kim JJ, MacKenzie KR, Ferreon ACM, Kim C, Ferreon JC. Nat Commun. 2021 Sep 22;12(1):5579. doi: 10.1038/s41467-021-25761-7. PubMed |
| Interaction between CD36 and FABP4 modulates adipocyte-induced fatty acid import and metabolism in breast cancer. Gyamfi J, Yeo JH, Kwon D, Min BS, Cha YJ, Koo JS, Jeong J, Lee J, Choi J. NPJ Breast Cancer. 2021 Sep 24;7(1):129. doi: 10.1038/s41523-021-00324-7. PubMed |
| The identification of a shorter cyclic GMP-AMP synthase gene from chickens and bioinformatics analysis of its potential signaling in IFN regulation. Zhu W, Cheng Y, Wang Z, Ji L, Ma J, Yan Y, Wang H, Sun J. Dev Comp Immunol. 2022 Feb;127:104266. doi: 10.1016/j.dci.2021.104266. Epub 2021 Sep 23. PubMed |
| A Co-Culture-Based Multiparametric Imaging Technique to Dissect Local H2O2 Signals with Targeted HyPer7. Secilmis M, Altun HY, Pilic J, Erdogan YC, Cokluk Z, Ata BN, Sevimli G, Zaki AG, Yigit EN, Ozturk G, Malli R, Eroglu E. Biosensors (Basel). 2021 Sep 14;11(9). pii: bios11090338. doi: 10.3390/bios11090338. PubMed |
| Perturbation-Based Modeling Unveils the Autophagic Modulation of Chemosensitivity and Immunogenicity in Breast Cancer Cells. Quiros-Fernandez I, Figueroa-Protti L, Arias-Arias JL, Brenes-Cordero N, Siles F, Mora J, Mora-Rodriguez RA. Metabolites. 2021 Sep 18;11(9). pii: metabo11090637. doi: 10.3390/metabo11090637. PubMed |
The Role of Pancreatic Alpha Cells and Endothelial Cells in the Reduction of Oxidative Stress in Pseudoislets.
Wieland FC, Sthijns MMJPE, Geuens T, van Blitterswijk CA, LaPointe VLS.
Front Bioeng Biotechnol. 2021 Sep 9;9:729057. doi: 10.3389/fbioe.2021.729057. eCollection 2021.
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| Capturing Salmonella SspH2 Host Targets in Virus-Like Particles. De Meyer M, Fijalkowski I, Jonckheere V, De Sutter D, Eyckerman S, Van Damme P. Front Med (Lausanne). 2021 Sep 8;8:725072. doi: 10.3389/fmed.2021.725072. eCollection 2021. PubMed |
| A persistent invasive phenotype in post-hypoxic tumor cells is revealed by fate mapping and computational modeling. Rocha HL, Godet I, Kurtoglu F, Metzcar J, Konstantinopoulos K, Bhoyar S, Gilkes DM, Macklin P. iScience. 2021 Aug 4;24(9):102935. doi: 10.1016/j.isci.2021.102935. eCollection 2021 Sep 24. PubMed |
| Assessing the Wnt-reactivity of cytonemes of mouse embryonic stem cells using a bioengineering approach. Junyent S, Reeves J, Habib SJ. STAR Protoc. 2021 Sep 15;2(3):100813. doi: 10.1016/j.xpro.2021.100813. eCollection 2021 Sep 17. PubMed |
| Titan Cells and Yeast Forms of Cryptococcus neoformans and Cryptococcus gattii Are Recognized by GXMR-CAR. Dos Santos MH, Machado MP, Kumaresan PR, da Silva TA. Microorganisms. 2021 Sep 5;9(9). pii: microorganisms9091886. doi: 10.3390/microorganisms9091886. PubMed |
| Efficient Inhibition of HIV Using CRISPR/Cas13d Nuclease System. Nguyen H, Wilson H, Jayakumar S, Kulkarni V, Kulkarni S. Viruses. 2021 Sep 16;13(9). pii: v13091850. doi: 10.3390/v13091850. PubMed |
| Methylglyoxal Forms Diverse Mercaptomethylimidazole Crosslinks with Thiol and Guanidine Pairs in Endogenous Metabolites and Proteins. Coukos JS, Moellering RE. ACS Chem Biol. 2021 Nov 19;16(11):2453-2461. doi: 10.1021/acschembio.1c00553. Epub 2021 Sep 28. PubMed |
| Regulatory variants at 2q33.1 confer schizophrenia risk by modulating distal gene TYW5 expression. Li S, Li J, Liu J, Wang J, Li X, Huo Y, Li Y, Liu Y, Li M, Xiao X, Luo XJ. Brain. 2022 Apr 18;145(2):770-786. doi: 10.1093/brain/awab357. PubMed |
| Beta-Pix-dynamin 2 complex promotes colorectal cancer progression by facilitating membrane dynamics. Keum S, Yang SJ, Park E, Kang T, Choi JH, Jeong J, Hwang YE, Kim JW, Park D, Rhee S. Cell Oncol (Dordr). 2021 Dec;44(6):1287-1305. doi: 10.1007/s13402-021-00637-6. Epub 2021 Sep 28. PubMed |
Revisiting astrocyte to neuron conversion with lineage tracing in vivo.
Wang LL, Serrano C, Zhong X, Ma S, Zou Y, Zhang CL.
Cell. 2021 Oct 14;184(21):5465-5481.e16. doi: 10.1016/j.cell.2021.09.005. Epub 2021 Sep 27.
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| A guide in lentiviral vector production for hard-to-transfect cells, using cardiac-derived c-kit expressing cells as a model system. Kalidasan V, Ng WH, Ishola OA, Ravichantar N, Tan JJ, Das KT. Sci Rep. 2021 Sep 28;11(1):19265. doi: 10.1038/s41598-021-98657-7. PubMed |
| Intravital imaging technology guides FAK-mediated priming in pancreatic cancer precision medicine according to Merlin status. Murphy KJ, Reed DA, Vennin C, Conway JRW, Nobis M, Yin JX, Chambers CR, Pereira BA, Lee V, Filipe EC, Trpceski M, Ritchie S, Lucas MC, Warren SC, Skhinas JN, Magenau A, Metcalf XL, Stoehr J, Major G, Parkin A, Bidanel R, Lyons RJ, Zaratzian A, Tayao M, Da Silva A, Abdulkhalek L, Gill AJ, Johns AL, Biankin AV, Samra J, Grimmond SM, Chou A, Goetz JG, Samuel MS, Lyons JG, Burgess A, Caldon CE, Horvath LG, Daly RJ, Gadegaard N, Wang Y, Sansom OJ, Morton JP, Cox TR, Pajic M, Herrmann D, Timpson P. Sci Adv. 2021 Oct;7(40):eabh0363. doi: 10.1126/sciadv.abh0363. Epub 2021 Sep 29. PubMed |
| Dendritic Cell-Specific Role for Pellino2 as a Mediator of TLR9 Signaling Pathway. Oleszycka E, Rodgers AM, Xu L, Moynagh PN. J Immunol. 2021 Nov 1;207(9):2325-2336. doi: 10.4049/jimmunol.2100236. Epub 2021 Sep 29. PubMed |
Unraveling the functional role of DNA demethylation at specific promoters by targeted steric blockage of DNA methyltransferase with CRISPR/dCas9.
Sapozhnikov DM, Szyf M.
Nat Commun. 2021 Sep 29;12(1):5711. doi: 10.1038/s41467-021-25991-9.
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Associated Plasmids |
| Mapping Genetic Interactions in Human Cancer Cells Using a One-Step tRNA-CRISPR System. Zhang DY, Gui X, Yang X. Methods Mol Biol. 2021;2381:175-187. doi: 10.1007/978-1-0716-1740-3_9. PubMed |
| Sphingosine 1-phosphate receptor type 2 positively regulates interleukin (IL)-4/IL-13-induced STAT6 phosphorylation. Okamoto Y, Kitakaze K, Takenouchi Y, Yamamoto S, Ishimaru H, Tsuboi K. Cell Signal. 2021 Dec;88:110156. doi: 10.1016/j.cellsig.2021.110156. Epub 2021 Sep 28. PubMed |
| Development of a DELFIA method to detect oncofetal antigen ROR1-positive exosomes. Daikuzono H, Yamazaki M, Sato Y, Takahashi T, Yamagata K. Biochem Biophys Res Commun. 2021 Nov 12;578:170-176. doi: 10.1016/j.bbrc.2021.08.054. Epub 2021 Aug 24. PubMed |
| A highly potent antibody effective against SARS-CoV-2 variants of concern. Fenwick C, Turelli P, Perez L, Pellaton C, Esteves-Leuenberger L, Farina A, Campos J, Lana E, Fiscalini F, Raclot C, Pojer F, Lau K, Demurtas D, Descatoire M, Joo VS, Foglierini M, Noto A, Abdelnabi R, Foo CS, Vangeel L, Neyts J, Du W, Bosch BJ, Veldman G, Leyssen P, Thiel V, LeGrand R, Levy Y, Trono D, Pantaleo G. Cell Rep. 2021 Oct 12;37(2):109814. doi: 10.1016/j.celrep.2021.109814. Epub 2021 Sep 21. PubMed |
| Overexpression of lncRNAs with endogenous lengths and functions using a lncRNA delivery system based on transposon. Zhang Y, Huang YX, Jin X, Chen J, Peng L, Wang DL, Li Y, Yao XY, Liao JY, He JH, Hu K, Lu D, Guo Y, Yin D. J Nanobiotechnology. 2021 Oct 2;19(1):303. doi: 10.1186/s12951-021-01044-7. PubMed |
| The deubiquitinase USP11 is a versatile and conserved regulator of autophagy. Basic M, Hertel A, Bajdzienko J, Bonn F, Tellechea M, Stolz A, Kern A, Behl C, Bremm A. J Biol Chem. 2021 Nov;297(5):101263. doi: 10.1016/j.jbc.2021.101263. Epub 2021 Sep 30. PubMed |
| Development and Initial Characterization of Cellular Models for COG Complex-Related CDG-II Diseases. Sumya FT, Pokrovskaya ID, Lupashin V. Front Genet. 2021 Sep 17;12:733048. doi: 10.3389/fgene.2021.733048. eCollection 2021. PubMed |
| Myogenin controls via AKAP6 non-centrosomal microtubule-organizing center formation at the nuclear envelope. Becker R, Vergarajauregui S, Billing F, Sharkova M, Lippolis E, Mamchaoui K, Ferrazzi F, Engel FB. Elife. 2021 Oct 4;10. pii: 65672. doi: 10.7554/eLife.65672. PubMed |
| PHDs/CPT1B/VDAC1 axis regulates long-chain fatty acid oxidation in cardiomyocytes. Angelini A, Saha PK, Jain A, Jung SY, Mynatt RL, Pi X, Xie L. Cell Rep. 2021 Oct 5;37(1):109767. doi: 10.1016/j.celrep.2021.109767. PubMed |
| A Simple, Rapid, and Cost-Effective Method for Loss-of-Function Assays in Pluripotent Cells. Covelo-Molares H, Souto Y, Fidalgo M, Guallar D. Methods Mol Biol. 2021 Oct 6. doi: 10.1007/7651_2021_434. PubMed |
A functional genetic toolbox for human tissue-derived organoids.
Sun D, Evans L, Perrone F, Sokleva V, Lim K, Rezakhani S, Lutolf M, Zilbauer M, Rawlins EL.
eLife. 2021 Oct 6;10. pii: 67886. doi: 10.7554/eLife.67886.
PubMed
Associated Plasmids |
AKAP79 enables calcineurin to directly suppress protein kinase A activity.
Church TW, Tewatia P, Hannan S, Antunes J, Eriksson O, Smart TG, Hellgren Kotaleski J, Gold MG.
Elife. 2021 Oct 6;10. pii: 68164. doi: 10.7554/eLife.68164.
PubMed
Associated Plasmids |
| Zika Virus Requires the Expression of Claudin-7 for Optimal Replication in Human Endothelial Cells. Zoladek J, Legros V, Jeannin P, Chazal M, Pardigon N, Ceccaldi PE, Gessain A, Jouvenet N, Afonso PV. Front Microbiol. 2021 Sep 20;12:746589. doi: 10.3389/fmicb.2021.746589. eCollection 2021. PubMed |
| Cochlear Sox2(+) Glial Cells Are Potent Progenitors for Spiral Ganglion Neuron Reprogramming Induced by Small Molecules. Chen Z, Huang Y, Yu C, Liu Q, Qiu C, Wan G. Front Cell Dev Biol. 2021 Sep 21;9:728352. doi: 10.3389/fcell.2021.728352. eCollection 2021. PubMed |
| CCNE1 copy number is a biomarker for response to combination WEE1-ATR inhibition in ovarian and endometrial cancer models. Xu H, George E, Kinose Y, Kim H, Shah JB, Peake JD, Ferman B, Medvedev S, Murtha T, Barger CJ, Devins KM, D'Andrea K, Wubbenhorst B, Schwartz LE, Hwang WT, Mills GB, Nathanson KL, Karpf AR, Drapkin R, Brown EJ, Simpkins F. Cell Rep Med. 2021 Sep 23;2(9):100394. doi: 10.1016/j.xcrm.2021.100394. eCollection 2021 Sep 21. PubMed |
| Detection and differentiation of murine leukemia virus (MLV) and murine stem cell virus (MSCV) and therefrom derived nucleic acids. Volkwein W, Pavlovic M, Anton M, Haase M, Stellberger T, Jarrar A, Busch U, Baiker A. J Virol Methods. 2022 Jan;299:114316. doi: 10.1016/j.jviromet.2021.114316. Epub 2021 Oct 7. PubMed |
| hnRNPA2B1 Promotes Colon Cancer Progression via the MAPK Pathway. Tang J, Chen Z, Wang Q, Hao W, Gao WQ, Xu H. Front Genet. 2021 Sep 22;12:666451. doi: 10.3389/fgene.2021.666451. eCollection 2021. PubMed |
Replacing the SpCas9 HNH domain by deaminases generates compact base editors with an alternative targeting scope.
Villiger L, Schmidheini L, Mathis N, Rothgangl T, Marquart K, Schwank G.
Mol Ther Nucleic Acids. 2021 Aug 26;26:502-510. doi: 10.1016/j.omtn.2021.08.025. eCollection 2021 Dec 3.
PubMed
Associated Plasmids |
| Sulfation of glycosaminoglycans depends on the catalytic activity of lithium-inhibited phosphatase BPNT2 in vitro. Eisele BS, Luka Z, Wu AJ, Yang F, Hale AT, York JD. J Biol Chem. 2021 Nov;297(5):101293. doi: 10.1016/j.jbc.2021.101293. Epub 2021 Oct 8. PubMed |
| IRAK1-dependent Regnase-1-14-3-3 complex formation controls Regnase-1-mediated mRNA decay. Akaki K, Ogata K, Yamauchi Y, Iwai N, Tse KM, Hia F, Mochizuki A, Ishihama Y, Mino T, Takeuchi O. Elife. 2021 Oct 12;10. pii: 71966. doi: 10.7554/eLife.71966. PubMed |
| TEC kinase stabilizes PLK4 to promote liver cancer metastasis. Yeung SF, Zhou Y, Zou W, Chan WL, Ching YP. Cancer Lett. 2022 Jan 1;524:70-81. doi: 10.1016/j.canlet.2021.08.038. Epub 2021 Oct 9. PubMed |
| MAPK15 Controls Hedgehog Signaling in Medulloblastoma Cells by Regulating Primary Ciliogenesis. Pietrobono S, Franci L, Imperatore F, Zanini C, Stecca B, Chiariello M. Cancers (Basel). 2021 Sep 29;13(19). pii: cancers13194903. doi: 10.3390/cancers13194903. PubMed |
| Transcription Factor RBPJL Is Able to Repress Notch Target Gene Expression but Is Non-Responsive to Notch Activation. Pan L, Hoffmeister P, Turkiewicz A, Huynh NND, Grosse-Berkenbusch A, Knippschild U, Gebhardt JCM, Baumann B, Borggrefe T, Oswald F. Cancers (Basel). 2021 Oct 8;13(19). pii: cancers13195027. doi: 10.3390/cancers13195027. PubMed |
| Cooperative methylation of human tRNA3Lys at positions A58 and U54 drives the early and late steps of HIV-1 replication. Fukuda H, Chujo T, Wei FY, Shi SL, Hirayama M, Kaitsuka T, Yamamoto T, Oshiumi H, Tomizawa K. Nucleic Acids Res. 2021 Nov 18;49(20):11855-11867. doi: 10.1093/nar/gkab879. PubMed |
| Specific Activation of the CD271 Intracellular Domain in Combination with Chemotherapy or Targeted Therapy Inhibits Melanoma Progression. Saltari A, Dzung A, Quadri M, Tiso N, Facchinello N, Hernandez-Barranco A, Garcia-Silva S, Nogues L, Stoffel CI, Cheng PF, Turko P, Eichhoff OM, Truzzi F, Marconi A, Pincelli C, Peinado H, Dummer R, Levesque MP. Cancer Res. 2021 Dec 1;81(23):6044-6057. doi: 10.1158/0008-5472.CAN-21-0117. Epub 2021 Oct 13. PubMed |
| Supraphysiologic Testosterone Induces Ferroptosis and Activates Immune Pathways through Nucleophagy in Prostate Cancer. Kumar R, Mendonca J, Owoyemi O, Boyapati K, Thomas N, Kanacharoen S, Coffey M, Topiwala D, Gomes C, Ozbek B, Jones T, Rosen M, Dong L, Wiens S, Brennen WN, Isaacs JT, De Marzo AM, Markowski MC, Antonarakis ES, Qian DZ, Pienta KJ, Pardoll DM, Carducci MA, Denmeade SR, Kachhap SK. Cancer Res. 2021 Dec 1;81(23):5948-5962. doi: 10.1158/0008-5472.CAN-20-3607. Epub 2021 Oct 13. PubMed |
| Site-specific N-glycosylation of integrin alpha2 mediates collagen-dependent cell survival. Huang YL, Liang CY, Labitzky V, Ritz D, Oliveira T, Cumin C, Estermann M, Lange T, Everest-Dass AV, Jacob F. iScience. 2021 Sep 25;24(10):103168. doi: 10.1016/j.isci.2021.103168. eCollection 2021 Oct 22. PubMed |
Plexin-B2 orchestrates collective stem cell dynamics via actomyosin contractility, cytoskeletal tension and adhesion.
Junqueira Alves C, Dariolli R, Haydak J, Kang S, Hannah T, Wiener RJ, DeFronzo S, Tejero R, Gusella GL, Ramakrishnan A, Alves Dias R, Wojcinski A, Kesari S, Shen L, Sobie EA, Rodrigues Furtado de Mendonca JP, Azeloglu EU, Zou H, Friedel RH.
Nat Commun. 2021 Oct 14;12(1):6019. doi: 10.1038/s41467-021-26296-7.
PubMed
Associated Plasmids |
| Human Erbb2-induced Erk activity robustly stimulates cycling and functional remodeling of rat and human cardiomyocytes. Strash N, DeLuca S, Janer Carattini GL, Heo SC, Gorsuch R, Bursac N. Elife. 2021 Oct 19;10. pii: 65512. doi: 10.7554/eLife.65512. PubMed |
| Translational repression of NMD targets by GIGYF2 and EIF4E2. Zinshteyn B, Sinha NK, Enam SU, Koleske B, Green R. PLoS Genet. 2021 Oct 19;17(10):e1009813. doi: 10.1371/journal.pgen.1009813. eCollection 2021 Oct. PubMed |
| Benzyl-para-di-[5-methyl-4-(n-octylamino) pyrimidin-2(1H)one] as an interferon beta (IFN-beta) modulator. Trifonov L, Yurchenko M, Skjesol A, Cohen G, Espevik T, Korshin EE, Grovdal LM, Husebye H, Gruzman A. Mol Divers. 2021 Oct 19. pii: 10.1007/s11030-021-10324-1. doi: 10.1007/s11030-021-10324-1. PubMed |
| Retinoic acid rewires the adrenergic core regulatory circuitry of childhood neuroblastoma. Zimmerman MW, Durbin AD, He S, Oppel F, Shi H, Tao T, Li Z, Berezovskaya A, Liu Y, Zhang J, Young RA, Abraham BJ, Look AT. Sci Adv. 2021 Oct 22;7(43):eabe0834. doi: 10.1126/sciadv.abe0834. Epub 2021 Oct 20. PubMed |
| Development of a selective fluorescence-based enzyme assay for glycerophosphodiesterase family members GDE4 and GDE7. Kitakaze K, Tsuboi K, Tsuda M, Takenouchi Y, Ishimaru H, Okamoto Y. J Lipid Res. 2021;62:100141. doi: 10.1016/j.jlr.2021.100141. Epub 2021 Oct 18. PubMed |
| Steroid sulfatase deficiency causes cellular senescence and abnormal differentiation by inducing Yippee-like 3 expression in human keratinocytes. Baek HS, Kwon TU, Shin S, Kwon YJ, Chun YJ. Sci Rep. 2021 Oct 21;11(1):20867. doi: 10.1038/s41598-021-00051-w. PubMed |
| Traf2 and NCK Interacting Kinase Is a Critical Regulator of Procollagen I Trafficking and Hepatic Fibrogenesis in Mice. Buchl SC, Hanquier Z, Haak AJ, Thomason YM, Huebert RC, Shah VH, Maiers JL. Hepatol Commun. 2022 Mar;6(3):593-609. doi: 10.1002/hep4.1835. Epub 2021 Oct 22. PubMed |
| CRISPR activation of endogenous genes reprograms fibroblasts into cardiovascular progenitor cells for myocardial infarction therapy. Jiang L, Liang J, Huang W, Ma J, Park KH, Wu Z, Chen P, Zhu H, Ma JJ, Cai W, Paul C, Niu L, Fan GC, Wang HS, Kanisicak O, Xu M, Wang Y. Mol Ther. 2022 Jan 5;30(1):54-74. doi: 10.1016/j.ymthe.2021.10.015. Epub 2021 Oct 20. PubMed |
| Deficiency of the Lysosomal Protein CLN5 Alters Lysosomal Function and Movement. Basak I, Hansen RA, Ward ME, Hughes SM. Biomolecules. 2021 Sep 27;11(10). pii: biom11101412. doi: 10.3390/biom11101412. PubMed |
| Effective chimeric antigen receptor T cells against SARS-CoV-2. Guo X, Kazanova A, Thurmond S, Saragovi HU, Rudd CE. iScience. 2021 Nov 19;24(11):103295. doi: 10.1016/j.isci.2021.103295. Epub 2021 Oct 16. PubMed |
| FCRL1 Regulates B Cell Receptor-Induced ERK Activation through GRB2. DeLuca JM, Murphy MK, Wang X, Wilson TJ. J Immunol. 2021 Dec 1;207(11):2688-2698. doi: 10.4049/jimmunol.2100218. Epub 2021 Oct 25. PubMed |
| Resistance of SARS-CoV-2 variants to neutralization by convalescent plasma from early COVID-19 outbreak in Singapore. Wang B, Goh YS, Prince T, Ngoh EZX, Salleh SNM, Hor PX, Loh CY, Fong SW, Hartley C, Tan SY, Young BE, Leo YS, Lye DC, Maurer-Stroh S, Ng LFP, Hiscox JA, Renia L, Wang CI. NPJ Vaccines. 2021 Oct 25;6(1):125. doi: 10.1038/s41541-021-00389-2. PubMed |
| Single-stranded DNA binding proteins influence APOBEC3A substrate preference. Brown AL, Collins CD, Thompson S, Coxon M, Mertz TM, Roberts SA. Sci Rep. 2021 Oct 25;11(1):21008. doi: 10.1038/s41598-021-00435-y. PubMed |
| PIM1 phosphorylation of the androgen receptor and 14-3-3 zeta regulates gene transcription in prostate cancer. Ruff SE, Vasilyev N, Nudler E, Logan SK, Garabedian MJ. Commun Biol. 2021 Oct 25;4(1):1221. doi: 10.1038/s42003-021-02723-9. PubMed |
| GAS1 is required for NOTCH-dependent facilitation of SHH signaling in the ventral forebrain neuroepithelium. Marczenke M, Sunaga-Franze DY, Popp O, Althaus IW, Sauer S, Mertins P, Christ A, Allen BL, Willnow TE. Development. 2021 Nov 1;148(21). pii: 272617. doi: 10.1242/dev.200080. Epub 2021 Nov 11. PubMed |
| Dnmt3a-mutated clonal hematopoiesis promotes osteoporosis. Kim PG, Niroula A, Shkolnik V, McConkey M, Lin AE, Slabicki M, Kemp JP, Bick A, Gibson CJ, Griffin G, Sekar A, Brooks DJ, Wong WJ, Cohen DN, Uddin MM, Shin WJ, Pirruccello J, Tsai JM, Agrawal M, Kiel DP, Bouxsein ML, Richards JB, Evans DM, Wein MN, Charles JF, Jaiswal S, Natarajan P, Ebert BL. J Exp Med. 2021 Dec 6;218(12). pii: 212724. doi: 10.1084/jem.20211872. Epub 2021 Oct 26. PubMed |
| Non-targeting control for MISSION shRNA library silences SNRPD3 leading to cell death or permanent growth arrest. Czarnek M, Sarad K, Karas A, Kochan J, Bereta J. Mol Ther Nucleic Acids. 2021 Sep 15;26:711-731. doi: 10.1016/j.omtn.2021.09.004. eCollection 2021 Dec 3. PubMed |
| Establishment of a pig CRISPR/Cas9 knockout library for functional gene screening in pig cells. Yu C, Zhong H, Yang X, Li G, Wu Z, Yang H. Biotechnol J. 2021 Oct 27:e2100408. doi: 10.1002/biot.202100408. PubMed |
| Defining the fetal origin of MLL-AF4 infant leukemia highlights specific fatty acid requirements. Symeonidou V, Jakobczyk H, Bashanfer S, Malouf C, Fotopoulou F, Kotecha RS, Anderson RA, Finch AJ, Ottersbach K. Cell Rep. 2021 Oct 26;37(4):109900. doi: 10.1016/j.celrep.2021.109900. PubMed |
| GCN2 adapts protein synthesis to scavenging-dependent growth. Nofal M, Wang T, Yang L, Jankowski CSR, Hsin-Jung Li S, Han S, Parsons L, Frese AN, Gitai Z, Anthony TG, Wuhr M, Sabatini DM, Rabinowitz JD. Cell Syst. 2022 Feb 16;13(2):158-172.e9. doi: 10.1016/j.cels.2021.09.014. Epub 2021 Oct 26. PubMed |
| Target Identification of Small Molecules Using Large-Scale CRISPR-Cas Mutagenesis Scanning of Essential Genes. Kwanten B, Neggers JE, Daelemans D. Methods Mol Biol. 2022;2377:43-67. doi: 10.1007/978-1-0716-1720-5_3. PubMed |
| RNA-responsive elements for eukaryotic translational control. Zhao EM, Mao AS, de Puig H, Zhang K, Tippens ND, Tan X, Ran FA, Han I, Nguyen PQ, Chory EJ, Hua TY, Ramesh P, Thompson DB, Oh CY, Zigon ES, English MA, Collins JJ. Nat Biotechnol. 2022 Apr;40(4):539-545. doi: 10.1038/s41587-021-01068-2. Epub 2021 Oct 28. PubMed |
| MI-773, a breaker of the MDM2/p53 axis, exhibits anticancer effects in neuroblastoma via downregulation of INSM1. Chen YL, Zhang ZM, Li XL, Tao YF, Wu SY, Fang F, Xie Y, Liao XM, Li G, Wu D, Wang HR, Zuo R, Cao HB, Pan JJ, Yu JJ, Zhang Z, Chu XR, Zhang YP, Feng CX, Wang JW, Lu J, Hu SY, Li ZH, Pan J. Oncol Lett. 2021 Dec;22(6):838. doi: 10.3892/ol.2021.13099. Epub 2021 Oct 18. PubMed |
| MiRNA-146a/AKT/beta-Catenin Activation Regulates Cancer Stem Cell Phenotype in Oral Squamous Cell Carcinoma by Targeting CD24. Ghuwalewala S, Ghatak D, Das S, Roy S, Das P, Butti R, Gorain M, Nath S, Kundu GC, Roychoudhury S. Front Oncol. 2021 Oct 12;11:651692. doi: 10.3389/fonc.2021.651692. eCollection 2021. PubMed |
| FACS-based protocol to assess cytotoxicity and clonogenic potential of colorectal cancer stem cells using a Wnt/beta-catenin signaling pathway reporter. Di Franco S, Zhang L, Gaggianesi M, Lo Iacono M, Medema JP, Stassi G. STAR Protoc. 2021 Oct 19;2(4):100880. doi: 10.1016/j.xpro.2021.100880. eCollection 2021 Dec 17. PubMed |
| Genetic, cellular, and structural characterization of the membrane potential-dependent cell-penetrating peptide translocation pore. Trofimenko E, Grasso G, Heulot M, Chevalier N, Deriu MA, Dubuis G, Arribat Y, Serulla M, Michel S, Vantomme G, Ory F, Dam LC, Puyal J, Amati F, Luthi A, Danani A, Widmann C. Elife. 2021 Oct 29;10. pii: 69832. doi: 10.7554/eLife.69832. PubMed |
| CHRAC1 promotes human lung cancer growth through regulating YAP transcriptional activity. Wang M, Li S, Guo W, Wang L, Huang J, Zhuo J, Lai B, Liao C, Ge T, Nie Y, Jin S, Wang M, Zhang Y, Liu Y, Li X, Zhang H. Carcinogenesis. 2022 Apr 25;43(3):264-276. doi: 10.1093/carcin/bgab103. PubMed |
| Control of osteocyte dendrite formation by Sp7 and its target gene osteocrin. Wang JS, Kamath T, Mazur CM, Mirzamohammadi F, Rotter D, Hojo H, Castro CD, Tokavanich N, Patel R, Govea N, Enishi T, Wu Y, da Silva Martins J, Bruce M, Brooks DJ, Bouxsein ML, Tokarz D, Lin CP, Abdul A, Macosko EZ, Fiscaletti M, Munns CF, Ryder P, Kost-Alimova M, Byrne P, Cimini B, Fujiwara M, Kronenberg HM, Wein MN. Nat Commun. 2021 Nov 1;12(1):6271. doi: 10.1038/s41467-021-26571-7. PubMed |
| Anti-apoptotic MCL1 Protein Represents Critical Survival Molecule for Most Burkitt Lymphomas and BCL2-negative Diffuse Large B-cell Lymphomas. Klanova M, Kazantsev D, Pokorna E, Zikmund T, Karolova J, Behounek M, Renesova N, Sovilj D, Kelemen CD, Helman K, Jaksa R, Havranek O, Andera L, Trneny M, Klener P. Mol Cancer Ther. 2022 Jan;21(1):89-99. doi: 10.1158/1535-7163.MCT-21-0511. Epub 2021 Nov 2. PubMed |
| Lentiviral and adeno-associated vectors efficiently transduce mouse T lymphocytes when targeted to murine CD8. Michels A, Frank AM, Gunther DM, Mataei M, Borner K, Grimm D, Hartmann J, Buchholz CJ. Mol Ther Methods Clin Dev. 2021 Oct 1;23:334-347. doi: 10.1016/j.omtm.2021.09.014. eCollection 2021 Dec 10. PubMed |
| Ibrutinib Blocks YAP1 Activation and Reverses BRAF Inhibitor Resistance in Melanoma Cells. Misek SA, Newbury PA, Chekalin E, Paithankar S, Doseff AI, Chen B, Gallo KA, Neubig RR. Mol Pharmacol. 2022 Jan;101(1):1-12. doi: 10.1124/molpharm.121.000331. Epub 2021 Nov 3. PubMed |
| ARV-825 Demonstrates Antitumor Activity in Gastric Cancer via MYC-Targets and G2M-Checkpoint Signaling Pathways. Liao X, Qian X, Zhang Z, Tao Y, Li Z, Zhang Q, Liang H, Li X, Xie Y, Zhuo R, Chen Y, Jiang Y, Cao H, Niu J, Xue C, Ni J, Pan J, Cui D. Front Oncol. 2021 Oct 18;11:753119. doi: 10.3389/fonc.2021.753119. eCollection 2021. PubMed |
| CRISPR-based RNA-binding protein mapping in live cells. Chen B, Shi H, Zhang J, Zhou C, Han M, Jiang W, Lai Y, Tu X, Li H. Biochem Biophys Res Commun. 2021 Oct 29;583:79-85. doi: 10.1016/j.bbrc.2021.10.059. PubMed |
| Chromatin-accessibility estimation from single-cell ATAC-seq data with scOpen. Li Z, Kuppe C, Ziegler S, Cheng M, Kabgani N, Menzel S, Zenke M, Kramann R, Costa IG. Nat Commun. 2021 Nov 4;12(1):6386. doi: 10.1038/s41467-021-26530-2. PubMed |
| Bovine mammary alveolar MAC-T cells afford a tool for studies of bovine milk exosomes in drug delivery. Ogunnaike M, Wang H, Zempleni J. Int J Pharm. 2021 Dec 15;610:121263. doi: 10.1016/j.ijpharm.2021.121263. Epub 2021 Nov 4. PubMed |
| CEBPG promotes acute myeloid leukemia progression by enhancing EIF4EBP1. Jiang Y, Wu SY, Chen YL, Zhang ZM, Tao YF, Xie Y, Liao XM, Li XL, Li G, Wu D, Wang HR, Zuo R, Cao HB, Pan JJ, Yu JJ, Jia SQ, Zhang Z, Chu XR, Zhang YP, Feng CX, Wang JW, Hu SY, Li ZH, Pan J, Fang F, Lu J. Cancer Cell Int. 2021 Nov 7;21(1):598. doi: 10.1186/s12935-021-02305-z. PubMed |
| Mutation Y453F in the spike protein of SARS-CoV-2 enhances interaction with the mink ACE2 receptor for host adaption. Ren W, Lan J, Ju X, Gong M, Long Q, Zhu Z, Yu Y, Wu J, Zhong J, Zhang R, Fan S, Zhong G, Huang A, Wang X, Ding Q. PLoS Pathog. 2021 Nov 8;17(11):e1010053. doi: 10.1371/journal.ppat.1010053. eCollection 2021 Nov. PubMed |
| Time-Resolved Scanning Ion Conductance Microscopy for Three-Dimensional Tracking of Nanoscale Cell Surface Dynamics. Leitao SM, Drake B, Pinjusic K, Pierrat X, Navikas V, Nievergelt AP, Brillard C, Djekic D, Radenovic A, Persat A, Constam DB, Anders J, Fantner GE. ACS Nano. 2021 Nov 9. doi: 10.1021/acsnano.1c05202. PubMed |
| The chemotherapeutic CX-5461 primarily targets TOP2B and exhibits selective activity in high-risk neuroblastoma. Pan M, Wright WC, Chapple RH, Zubair A, Sandhu M, Batchelder JE, Huddle BC, Low J, Blankenship KB, Wang Y, Gordon B, Archer P, Brady SW, Natarajan S, Posgai MJ, Schuetz J, Miller D, Kalathur R, Chen S, Connelly JP, Babu MM, Dyer MA, Pruett-Miller SM, Freeman BB 3rd, Chen T, Godley LA, Blanchard SC, Stewart E, Easton J, Geeleher P. Nat Commun. 2021 Nov 9;12(1):6468. doi: 10.1038/s41467-021-26640-x. PubMed |
| The cell-surface 5'-nucleotidase CD73 defines a functional T memory cell subset that declines with age. Fang F, Cao W, Zhu W, Lam N, Li L, Gaddam S, Wang Y, Kim C, Lambert S, Zhang H, Hu B, Farber DL, Weyand CM, Goronzy JJ. Cell Rep. 2021 Nov 9;37(6):109981. doi: 10.1016/j.celrep.2021.109981. PubMed |
| TIAM1-RAC1 promote small-cell lung cancer cell survival through antagonizing Nur77-induced BCL2 conformational change. Payapilly A, Guilbert R, Descamps T, White G, Magee P, Zhou C, Kerr A, Simpson KL, Blackhall F, Dive C, Malliri A. Cell Rep. 2021 Nov 9;37(6):109979. doi: 10.1016/j.celrep.2021.109979. PubMed |
| The specificity of the malarial VAR2CSA protein for chondroitin sulfate depends on 4-O-sulfation and ligand accessibility. Spliid CB, Toledo AG, Sanderson P, Mao Y, Gatto F, Gustavsson T, Choudhary S, Saldanha AL, Vogelsang RP, Gogenur I, Theander TG, Leach FE 3rd, Amster IJ, Esko JD, Salanti A, Clausen TM. J Biol Chem. 2021 Dec;297(6):101391. doi: 10.1016/j.jbc.2021.101391. Epub 2021 Nov 8. PubMed |
| The phosphoinositide coincidence detector Phafin2 promotes macropinocytosis by coordinating actin organisation at forming macropinosomes. Schink KO, Tan KW, Spangenberg H, Martorana D, Sneeggen M, Stevenin V, Enninga J, Campsteijn C, Raiborg C, Stenmark H. Nat Commun. 2021 Nov 12;12(1):6577. doi: 10.1038/s41467-021-26775-x. PubMed |
| Altered vitamin K biodistribution and metabolism in experimental and human chronic kidney disease. Kaesler N, Schreibing F, Speer T, Puente-Secades S, Rapp N, Drechsler C, Kabgani N, Kuppe C, Boor P, Jankowski V, Schurgers L, Kramann R, Floege J. Kidney Int. 2022 Feb;101(2):338-348. doi: 10.1016/j.kint.2021.10.029. Epub 2021 Nov 11. PubMed |
| Integrin alpha5 mediates cancer cell-fibroblast adhesion and peritoneal dissemination of diffuse-type gastric carcinoma. Miyamoto S, Nagano Y, Miyazaki M, Nagamura Y, Sasaki K, Kawamura T, Yanagihara K, Imai T, Ohki R, Yashiro M, Tanaka M, Sakai R, Yamaguchi H. Cancer Lett. 2022 Feb 1;526:335-345. doi: 10.1016/j.canlet.2021.11.008. Epub 2021 Nov 12. PubMed |
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| Identification of Cellular Factors Required for SARS-CoV-2 Replication. Synowiec A, Jedrysik M, Branicki W, Klajmon A, Lei J, Owczarek K, Suo C, Szczepanski A, Wang J, Zhang P, Labaj PP, Pyrc K. Cells. 2021 Nov 13;10(11). pii: cells10113159. doi: 10.3390/cells10113159. PubMed |
Deciphering cell signaling networks with massively multiplexed biosensor barcoding.
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| Genetically edited hepatic cells expressing the NTCP-S267F variant are resistant to hepatitis B virus infection. Uchida T, Park SB, Inuzuka T, Zhang M, Allen JN, Chayama K, Liang TJ. Mol Ther Methods Clin Dev. 2021 Nov 10;23:597-605. doi: 10.1016/j.omtm.2021.11.002. eCollection 2021 Dec 10. PubMed |
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| Apoptolidin family glycomacrolides target leukemia through inhibition of ATP synthase. Reisman BJ, Guo H, Ramsey HE, Wright MT, Reinfeld BI, Ferrell PB, Sulikowski GA, Rathmell WK, Savona MR, Plate L, Rubinstein JL, Bachmann BO. Nat Chem Biol. 2022 Apr;18(4):360-367. doi: 10.1038/s41589-021-00900-9. Epub 2021 Dec 2. PubMed |
| Large Multicohort Study Reveals a Prostate Cancer Susceptibility Allele at 5p15 Regulating TERT via Androgen Signaling-Orchestrated Chromatin Binding of E2F1 and MYC. Dong X, Zhang Q, Hao J, Xie Q, Xu B, Zhang P, Lu H, Huang Q, Yang T, Wei GH, Na R, Gao P. Front Oncol. 2021 Nov 10;11:754206. doi: 10.3389/fonc.2021.754206. eCollection 2021. PubMed |
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| A Nucleocapsid-based Transcomplementation Cell Culture System of SARS-CoV-2 to Recapitulate the Complete Viral Life Cycle. Yu Y, Ju X, Ding Q. Bio Protoc. 2021 Nov 5;11(21):e4257. doi: 10.21769/BioProtoc.4257. eCollection 2021 Nov 5. PubMed |
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| Identification of Drug Transporter Genomic Variants and Inhibitors That Protect Against Doxorubicin-Induced Cardiotoxicity. Magdy T, Jouni M, Kuo HH, Weddle CJ, Lyra-Leite D, Fonoudi H, Romero-Tejeda M, Gharib M, Javed H, Fajardo G, Ross CJD, Carleton BC, Bernstein D, Burridge PW. Circulation. 2022 Jan 25;145(4):279-294. doi: 10.1161/CIRCULATIONAHA.121.055801. Epub 2021 Dec 7. PubMed |
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| TIFAB accelerates MLL-AF9-Induced acute myeloid leukemia through upregulation of HOXA9. Zhao J, Xiu Y, Fu L, Dong Q, Borcherding N, Wang Y, Li Q, De Silva NS, Klein U, Boyce BF, Zhao C. iScience. 2021 Nov 12;24(12):103425. doi: 10.1016/j.isci.2021.103425. eCollection 2021 Dec 17. PubMed |
| Integrated stress response regulates GDF15 secretion from adipocytes, preferentially suppresses appetite for a high-fat diet and improves obesity. Miyake M, Zhang J, Yasue A, Hisanaga S, Tsugawa K, Sakaue H, Oyadomari M, Kiyonari H, Oyadomari S. iScience. 2021 Nov 15;24(12):103448. doi: 10.1016/j.isci.2021.103448. eCollection 2021 Dec 17. PubMed |
| Inhibition of the PLK1-Coupled Cell Cycle Machinery Overcomes Resistance to Oxaliplatin in Colorectal Cancer. Yu Z, Deng P, Chen Y, Liu S, Chen J, Yang Z, Chen J, Fan X, Wang P, Cai Z, Wang Y, Hu P, Lin D, Xiao R, Zou Y, Huang Y, Yu Q, Lan P, Tan J, Wu X. Adv Sci (Weinh). 2021 Dec;8(23):e2100759. doi: 10.1002/advs.202100759. Epub 2021 Oct 28. PubMed |
Integrated genome and tissue engineering enables screening of cancer vulnerabilities in physiologically relevant perfusable ex vivo cultures.
Hu M, Lei XY, Larson JD, McAlonis M, Ford K, McDonald D, Mach K, Rusert JM, Wechsler-Reya RJ, Mali P.
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| Rational design and construction of multi-copy biomanufacturing islands in mammalian cells. Altamura R, Doshi J, Benenson Y. Nucleic Acids Res. 2022 Jan 11;50(1):561-578. doi: 10.1093/nar/gkab1214. PubMed |
| Bone marrow derived-mesenchymal stem cell improves diabetes-associated fatty liver via mitochondria transformation in mice. Bi Y, Guo X, Zhang M, Zhu K, Shi C, Fan B, Wu Y, Yang Z, Ji G. Stem Cell Res Ther. 2021 Dec 11;12(1):602. doi: 10.1186/s13287-021-02663-5. PubMed |
| BoxCar and shotgun proteomic analyses reveal molecular networks regulated by UBR5 in prostate cancer. Yan Y, Zhou B, Lee YJ, You S, Freeman MR, Yang W. Proteomics. 2022 Feb;22(4):e2100172. doi: 10.1002/pmic.202100172. Epub 2021 Dec 23. PubMed |
| The OM-85 bacterial lysate inhibits SARS-CoV-2 infection of epithelial cells by downregulating SARS-CoV-2 receptor expression. Pivniouk V, Pivniouk O, DeVries A, Uhrlaub JL, Michael A, Pivniouk D, VanLinden SR, Conway MY, Hahn S, Malone SP, Ezeh P, Churko JM, Anderson D, Kraft M, Nikolich-Zugich J, Vercelli D. J Allergy Clin Immunol. 2022 Mar;149(3):923-933.e6. doi: 10.1016/j.jaci.2021.11.019. Epub 2021 Dec 10. PubMed |
| Nuclear pore protein NUP210 depletion suppresses metastasis through heterochromatin-mediated disruption of tumor cell mechanical response. Amin R, Shukla A, Zhu JJ, Kim S, Wang P, Tian SZ, Tran AD, Paul D, Cappell SD, Burkett S, Liu H, Lee MP, Kruhlak MJ, Dwyer JE, Simpson RM, Hager GL, Ruan Y, Hunter KW. Nat Commun. 2021 Dec 13;12(1):7216. doi: 10.1038/s41467-021-27451-w. PubMed |
| Peroxisomal beta-oxidation acts as a sensor for intracellular fatty acids and regulates lipolysis. Ding L, Sun W, Balaz M, He A, Klug M, Wieland S, Caiazzo R, Raverdy V, Pattou F, Lefebvre P, Lodhi IJ, Staels B, Heim M, Wolfrum C. Nat Metab. 2021 Dec;3(12):1648-1661. doi: 10.1038/s42255-021-00489-2. Epub 2021 Dec 13. PubMed |
| A minimal standardized human bone marrow microphysiological system to assess resident cell behavior during normal and pathological processes. Voeltzel T, Fossard G, Degaud M, Geistlich K, Gadot N, Jeanpierre S, Mikaelian I, Brevet M, Anginot A, Le Bousse-Kerdiles MC, Trichet V, Lefort S, Maguer-Satta V. Biomater Sci. 2022 Jan 18;10(2):485-498. doi: 10.1039/d1bm01098k. PubMed |
| Generation and Hematopoietic Differentiation of Mesenchymal Stromal/Stem Cell-Derived Induced Pluripotent Stem Cell Lines for Disease Modeling of Hematopoietic and Immunological Diseases. Guney-Esken G, Aerts-Kaya F. Methods Mol Biol. 2021 Dec 15. doi: 10.1007/7651_2021_452. PubMed |
| Biallelic mutations in calcium release activated channel regulator 2A (CRACR2A) cause a primary immunodeficiency disorder. Wu B, Rice L, Shrimpton J, Lawless D, Walker K, Carter C, McKeown L, Anwar R, Doody GM, Srikanth S, Gwack Y, Savic S. Elife. 2021 Dec 15;10. pii: 72559. doi: 10.7554/eLife.72559. PubMed |
Individual human cortical progenitors can produce excitatory and inhibitory neurons.
Delgado RN, Allen DE, Keefe MG, Mancia Leon WR, Ziffra RS, Crouch EE, Alvarez-Buylla A, Nowakowski TJ.
Nature. 2021 Dec 15. pii: 10.1038/s41586-021-04230-7. doi: 10.1038/s41586-021-04230-7.
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| Downregulation of METTL6 mitigates cell progression, migration, invasion and adhesion in hepatocellular carcinoma by inhibiting cell adhesion molecules. Bolatkan A, Asada K, Kaneko S, Suvarna K, Ikawa N, Machino H, Komatsu M, Shiina S, Hamamoto R. Int J Oncol. 2022 Jan;60(1). pii: 4. doi: 10.3892/ijo.2021.5294. Epub 2021 Dec 16. PubMed |
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| A mechanistic basis for the malignant progression of salivary gland tumors. Taniguchi S, Tanaka Y, Elhance A, Oshimori N. iScience. 2021 Nov 25;24(12):103508. doi: 10.1016/j.isci.2021.103508. eCollection 2021 Dec 17. PubMed |
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| Squalene synthase predicts poor prognosis in stage I-III colon adenocarcinoma and synergizes squalene epoxidase to promote tumor progression. Jiang H, Tang E, Chen Y, Liu H, Zhao Y, Lin M, He L. Cancer Sci. 2022 Mar;113(3):971-985. doi: 10.1111/cas.15248. Epub 2022 Jan 6. PubMed |
| Anti-SARS-CoV-2 Activity of Rhamnan Sulfate from Monostroma nitidum. Song Y, He P, Rodrigues AL, Datta P, Tandon R, Bates JT, Bierdeman MA, Chen C, Dordick J, Zhang F, Linhardt RJ. Mar Drugs. 2021 Nov 30;19(12). pii: md19120685. doi: 10.3390/md19120685. PubMed |
| Perturbation of Cellular Redox Homeostasis Dictates Divergent Effects of Polybutyl Cyanoacrylate (PBCA) Nanoparticles on Autophagy. Sonstevold T, Engedal N, Torgersen ML. Cells. 2021 Dec 6;10(12). pii: cells10123432. doi: 10.3390/cells10123432. PubMed |
| Entrectinib-A SARS-CoV-2 Inhibitor in Human Lung Tissue (HLT) Cells. Peralta-Garcia A, Torrens-Fontanals M, Stepniewski TM, Grau-Exposito J, Perea D, Ayinampudi V, Waldhoer M, Zimmermann M, Buzon MJ, Genesca M, Selent J. Int J Mol Sci. 2021 Dec 18;22(24). pii: ijms222413592. doi: 10.3390/ijms222413592. PubMed |
| RNA uridyl transferases TUT4/7 differentially regulate miRNA variants depending on the cancer cell type. Medhi R, Price J, Furlan G, Gorges B, Sapetschnig A, Miska EA. RNA. 2022 Mar;28(3):353-370. doi: 10.1261/rna.078976.121. Epub 2021 Dec 23. PubMed |
| A protocol for imaging microvilli biogenesis on the surface of cultured porcine kidney epithelial cell monolayers. Gaeta IM, Meenderink LM, Tyska MJ. STAR Protoc. 2021 Dec 10;2(4):100998. doi: 10.1016/j.xpro.2021.100998. eCollection 2021 Dec 17. PubMed |
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| Etched 3D-Printed Polycaprolactone Constructs Functionalized with Reduced Graphene Oxide for Enhanced Attachment of Dental Pulp-Derived Stem Cells. Bow AJ, Masi TJ, Dhar MS. Pharmaceutics. 2021 Dec 13;13(12). pii: pharmaceutics13122146. doi: 10.3390/pharmaceutics13122146. PubMed |
| Peroxidasin Enhances Basal Phenotype and Inhibits Branching Morphogenesis in Breast Epithelial Progenitor Cell Line D492. Sigurdardottir AK, Jonasdottir AS, Asbjarnarson A, Helgudottir HR, Gudjonsson T, Traustadottir GA. J Mammary Gland Biol Neoplasia. 2021 Dec;26(4):321-338. doi: 10.1007/s10911-021-09507-1. Epub 2021 Dec 28. PubMed |
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| GPNMB overexpression is associated with extensive bone metastasis and poor prognosis in renal cell carcinoma. Zhai JP, Liu ZH, Wang HD, Huang GL, Man LB. Oncol Lett. 2022 Jan;23(1):36. doi: 10.3892/ol.2021.13154. Epub 2021 Dec 1. PubMed |
| Measuring Autophagic Cargo Flux with Keima-Based Probes. Engedal N, Sonstevold T, Beese CJ, Selladurai S, Melcher T, Simensen JE, Frankel LB, Urbanucci A, Torgersen ML. Methods Mol Biol. 2022;2445:99-115. doi: 10.1007/978-1-0716-2071-7_7. PubMed |
| Engineering of human mesenchymal stem cells resistant to multiple natural killer subtypes. Zheng D, Wang X, Zhang Z, Li E, Yeung C, Borkar R, Qin G, Wu Y, Xu RH. Int J Biol Sci. 2022 Jan 1;18(1):426-440. doi: 10.7150/ijbs.64640. eCollection 2022. PubMed |
| HIF1alpha/HIF2alpha induces glioma cell dedifferentiation into cancer stem cells through Sox2 under hypoxic conditions. Wang P, Gong S, Liao B, Pan J, Wang J, Zou D, Zhao L, Xiong S, Deng Y, Yan Q, Wu N. J Cancer. 2022 Jan 1;13(1):1-14. doi: 10.7150/jca.54402. eCollection 2022. PubMed |
| Intestinal organoid co-culture protocol to study cell competition in vitro. van Neerven SM, Ramadan R, van Driel MS, Huels DJ, Vermeulen L. STAR Protoc. 2021 Dec 16;3(1):101050. doi: 10.1016/j.xpro.2021.101050. eCollection 2022 Mar 18. PubMed |
| Specific inhibition of the NLRP3 inflammasome suppresses immune overactivation and alleviates COVID-19 like pathology in mice. Zeng J, Xie X, Feng XL, Xu L, Han JB, Yu D, Zou QC, Liu Q, Li X, Ma G, Li MH, Yao YG. EBioMedicine. 2022 Jan;75:103803. doi: 10.1016/j.ebiom.2021.103803. Epub 2021 Dec 31. PubMed |
| HDLs extract lipophilic drugs from cells. Zheng A, Dubuis G, Georgieva M, Mendes Ferreira CS, Serulla M, Del Carmen Conde Rubio M, Trofimenko E, Mercier T, Decosterd L, Widmann C. J Cell Sci. 2022 Mar 1;135(5):jcs258644. doi: 10.1242/jcs.258644. Epub 2022 Jan 31. PubMed |
| Engineered small extracellular vesicles displaying ACE2 variants on the surface protect against SARS-CoV-2 infection. Kim HK, Cho J, Kim E, Kim J, Yang JS, Kim KC, Lee JY, Shin Y, Palomera LF, Park J, Baek SH, Bae HG, Cho Y, Han J, Sul JH, Lee J, Park JH, Cho YW, Lee W, Jo DG. J Extracell Vesicles. 2022 Jan;11(1):e12179. doi: 10.1002/jev2.12179. PubMed |
| Necrotic debris and STING exert therapeutically relevant effects on tumor cholesterol homeostasis. Katakam S, Anand S, Martin P, Riggi N, Stamenkovic I. Life Sci Alliance. 2022 Jan 4;5(3):e202101256. doi: 10.26508/lsa.202101256. Print 2022 Mar. PubMed |
| Enhancing the HSV-1-mediated antitumor immune response by suppressing Bach1. Pan C, Cai Q, Li X, Li L, Yang L, Chen Y, Liu J, Liu W, Gao M, Sui T, Wang X, Fan H, Ruan J, Shi Y, Chen S, Cheng LS, Liu J, Yang H, Cheng G. Cell Mol Immunol. 2022 Apr;19(4):516-526. doi: 10.1038/s41423-021-00824-3. Epub 2022 Jan 5. PubMed |
| Insulin sensitivity in the aged heart is improved by down-regulation of KAT7 in vivo and in vitro. Wang B, Li J, Liu L, Song G. Cell Cycle. 2022 Feb;21(3):276-288. doi: 10.1080/15384101.2021.2018811. Epub 2022 Jan 6. PubMed |
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| C2cd6-encoded CatSpertau targets sperm calcium channel to Ca(2+) signaling domains in the flagellar membrane. Hwang JY, Wang H, Lu Y, Ikawa M, Chung JJ. Cell Rep. 2022 Jan 18;38(3):110226. doi: 10.1016/j.celrep.2021.110226. Epub 2022 Jan 7. PubMed |
| Circadian disruption and cisplatin chronotherapy for mammary carcinoma. Koritala BSC, Porter KI, Sarkar S, Gaddameedhi S. Toxicol Appl Pharmacol. 2022 Feb 1;436:115863. doi: 10.1016/j.taap.2022.115863. Epub 2022 Jan 5. PubMed |
| Progerin-expressing endothelial cells are unable to adapt to shear stress. Danielsson BE, Peters HC, Bathula K, Spear LM, Noll NA, Dahl KN, Conway DE. Biophys J. 2022 Feb 15;121(4):620-628. doi: 10.1016/j.bpj.2022.01.004. Epub 2022 Jan 6. PubMed |
| A one-step platform for screening high-efficient and minimal off-target CRISPR/Cas13 crRNAs to eradicate SARS-CoV-2 virus for treatment of COVID-19 patients. Li PY, Li SQ, Gao SG, Dong DY. Med Hypotheses. 2022 Feb;159:110754. doi: 10.1016/j.mehy.2021.110754. Epub 2022 Jan 4. PubMed |
| Intracellular IL-32 regulates mitochondrial metabolism, proliferation, and differentiation of malignant plasma cells. Aass KR, Mjelle R, Kastnes MH, Tryggestad SS, van den Brink LM, Aass Roseth I, Westhrin M, Zahoor M, Moen SH, Vikene Nedal TM, Buene G, Misund K, Sponaas AM, Ma Q, Sundan A, Groen RW, Slordahl TS, Waage A, Standal T. iScience. 2021 Dec 13;25(1):103605. doi: 10.1016/j.isci.2021.103605. eCollection 2022 Jan 21. PubMed |
| Biophysical Characterization of Novel DNA Aptamers against K103N/Y181C Double Mutant HIV-1 Reverse Transcriptase. Ratanabunyong S, Seetaha S, Hannongbua S, Yanaka S, Yagi-Utsumi M, Kato K, Paemanee A, Choowongkomon K. Molecules. 2022 Jan 3;27(1):285. doi: 10.3390/molecules27010285. PubMed |
| The metabolic stress-activated checkpoint LKB1-MARK3 axis acts as a tumor suppressor in high-grade serous ovarian carcinoma. Machino H, Kaneko S, Komatsu M, Ikawa N, Asada K, Nakato R, Shozu K, Dozen A, Sone K, Yoshida H, Kato T, Oda K, Osuga Y, Fujii T, von Keudell G, Saloura V, Hamamoto R. Commun Biol. 2022 Jan 11;5(1):39. doi: 10.1038/s42003-021-02992-4. PubMed |
| RECON syndrome is a genome instability disorder caused by mutations in the DNA helicase RECQL1. Abu-Libdeh B, Jhujh SS, Dhar S, Sommers JA, Datta A, Longo GM, Grange LJ, Reynolds JJ, Cooke SL, McNee GS, Hollingworth R, Woodward BL, Ganesh AN, Smerdon SJ, Nicolae CM, Durlacher-Betzer K, Molho-Pessach V, Abu-Libdeh A, Meiner V, Moldovan GL, Roukos V, Harel T, Brosh RM Jr, Stewart GS. J Clin Invest. 2022 Mar 1;132(5). pii: 147301. doi: 10.1172/JCI147301. PubMed |
| SARS-CoV-2 mRNA vaccination elicits a robust and persistent T follicular helper cell response in humans. Mudd PA, Minervina AA, Pogorelyy MV, Turner JS, Kim W, Kalaidina E, Petersen J, Schmitz AJ, Lei T, Haile A, Kirk AM, Mettelman RC, Crawford JC, Nguyen THO, Rowntree LC, Rosati E, Richards KA, Sant AJ, Klebert MK, Suessen T, Middleton WD, Wolf J, Teefey SA, O'Halloran JA, Presti RM, Kedzierska K, Rossjohn J, Thomas PG, Ellebedy AH. Cell. 2022 Feb 17;185(4):603-613.e15. doi: 10.1016/j.cell.2021.12.026. Epub 2021 Dec 23. PubMed |
| Spindle pole body component 24 homolog potentiates tumor progression via regulation of SRY-box transcription factor 2 in clear cell renal cell carcinoma. Sun C, Wei J, Long Z, Zhao W, Huangfu Q, Xie Q, Wang B, Wen J. FASEB J. 2022 Feb;36(2):e22086. doi: 10.1096/fj.202101310R. PubMed |
| Using genetically modified extracellular vesicles as a non-invasive strategy to evaluate brain-specific cargo. Rufino-Ramos D, Lule S, Mahjoum S, Ughetto S, Cristopher Bragg D, Pereira de Almeida L, Breakefield XO, Breyne K. Biomaterials. 2022 Feb;281:121366. doi: 10.1016/j.biomaterials.2022.121366. Epub 2022 Jan 8. PubMed |
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| V-CARMA: A tool for the detection and modification of antigen-specific T cells. Guo XJ, Elledge SJ. Proc Natl Acad Sci U S A. 2022 Jan 25;119(4). pii: 2116277119. doi: 10.1073/pnas.2116277119. PubMed |
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| Impaired catabolism of free oligosaccharides due to MAN2C1 variants causes a neurodevelopmental disorder. Maia N, Potelle S, Yildirim H, Duvet S, Akula SK, Schulz C, Wiame E, Gheldof A, O'Kane K, Lai A, Sermon K, Proisy M, Loget P, Attie-Bitach T, Quelin C, Fortuna AM, Soares AR, de Brouwer APM, Van Schaftingen E, Nassogne MC, Walsh CA, Stouffs K, Jorge P, Jansen AC, Foulquier F. Am J Hum Genet. 2022 Feb 3;109(2):345-360. doi: 10.1016/j.ajhg.2021.12.010. Epub 2022 Jan 18. PubMed |
| Adipocyte-Specific Inhibition of Mir221/222 Ameliorates Diet-Induced Obesity Through Targeting Ddit4. Yamaguchi S, Zhang D, Katayama A, Kurooka N, Sugawara R, Albuayjan HHH, Nakatsuka A, Eguchi J, Wada J. Front Endocrinol (Lausanne). 2022 Jan 3;12:750261. doi: 10.3389/fendo.2021.750261. eCollection 2021. PubMed |
| Baf45a Mediated Chromatin Remodeling Promotes Transcriptional Activation for Osteogenesis and Odontogenesis. Busby T, Chen Y, Godfrey TC, Rehan M, Wildman BJ, Smith CM, Hassan Q. Front Endocrinol (Lausanne). 2022 Jan 3;12:763392. doi: 10.3389/fendo.2021.763392. eCollection 2021. PubMed |
| Identification of the Cysteine Protease Legumain as a Potential Chronic Hypoxia-Specific Multiple Myeloma Target Gene. Clees AS, Stolp V, Haupl B, Fuhrmann DC, Wempe F, Seibert M, Weber S, Banning A, Tikkanen R, Williams R, Brune B, Serve H, Schnutgen F, von Metzler I, Kurrle N. Cells. 2022 Jan 15;11(2). pii: cells11020292. doi: 10.3390/cells11020292. PubMed |
| CRISPR-Cas9 Screen Identifies DYRK1A as a Target for Radiotherapy Sensitization in Pancreatic Cancer. Lan B, Zeng S, Zhang S, Ren X, Xing Y, Kutschick I, Pfeffer S, Frey B, Britzen-Laurent N, Grutzmann R, Cordes N, Pilarsky C. Cancers (Basel). 2022 Jan 10;14(2). pii: cancers14020326. doi: 10.3390/cancers14020326. PubMed |
| STAT3 Enhances Sensitivity of Glioblastoma to Drug-Induced Autophagy-Dependent Cell Death. Remy J, Linder B, Weirauch U, Day BW, Stringer BW, Herold-Mende C, Aigner A, Krohn K, Kogel D. Cancers (Basel). 2022 Jan 11;14(2). pii: cancers14020339. doi: 10.3390/cancers14020339. PubMed |
| Impact of Formulation Conditions on Lipid Nanoparticle Characteristics and Functional Delivery of CRISPR RNP for Gene Knock-Out and Correction. Walther J, Wilbie D, Tissingh VSJ, Oktem M, van der Veen H, Lou B, Mastrobattista E. Pharmaceutics. 2022 Jan 17;14(1):213. doi: 10.3390/pharmaceutics14010213. PubMed |
| PGK1 represses autophagy-mediated cell death to promote the proliferation of liver cancer cells by phosphorylating PRAS40. Zhang T, Wang Y, Yu H, Zhang T, Guo L, Xu J, Wei X, Wang N, Wu Y, Wang X, Huang L. Cell Death Dis. 2022 Jan 20;13(1):68. doi: 10.1038/s41419-022-04499-0. PubMed |
| Photodynamic Inactivation of Human Coronaviruses. Duguay BA, Herod A, Pringle ES, Monro SMA, Hetu M, Cameron CG, McFarland SA, McCormick C. Viruses. 2022 Jan 8;14(1). pii: v14010110. doi: 10.3390/v14010110. PubMed |
| KIR2DL4 promotes the proliferation of RCC cell associated with PI3K/Akt signaling activation. Ding XF, Chen J, Ma HL, Liang Y, Wang YF, Zhang HT, Li X, Chen G. Life Sci. 2022 Mar 15;293:120320. doi: 10.1016/j.lfs.2022.120320. Epub 2022 Jan 19. PubMed |
| JAM-A interacts with alpha3beta1 integrin and tetraspanins CD151 and CD9 to regulate collective cell migration of polarized epithelial cells. Tholmann S, Seebach J, Otani T, Florin L, Schnittler H, Gerke V, Furuse M, Ebnet K. Cell Mol Life Sci. 2022 Jan 24;79(2):88. doi: 10.1007/s00018-022-04140-5. PubMed |
| Golgi phosphoprotein 3 promotes angiogenesis and sorafenib resistance in hepatocellular carcinoma via upregulating exosomal miR-494-3p. Gao Y, Yin Z, Qi Y, Peng H, Ma W, Wang R, Li W. Cancer Cell Int. 2022 Jan 24;22(1):35. doi: 10.1186/s12935-022-02462-9. PubMed |
| CHAF1A/B mediate silencing of unintegrated HIV-1 DNAs early in infection. Geis FK, Sabo Y, Chen X, Li Y, Lu C, Goff SP. Proc Natl Acad Sci U S A. 2022 Jan 25;119(4):e2116735119. doi: 10.1073/pnas.2116735119. PubMed |
| Nucleotide biosynthesis links glutathione metabolism to ferroptosis sensitivity. Tarangelo A, Rodencal J, Kim JT, Magtanong L, Long JZ, Dixon SJ. Life Sci Alliance. 2022 Jan 24;5(4):e202101157. doi: 10.26508/lsa.202101157. Print 2022 Apr. PubMed |
| Identification of a STIM1 Splicing Variant that Promotes Glioblastoma Growth. Xie J, Ma G, Zhou L, He L, Zhang Z, Tan P, Huang Z, Fang S, Wang T, Lee YT, Wen S, Siwko S, Wang L, Liu J, Du Y, Zhang N, Liu X, Han L, Huang Y, Wang R, Wang Y, Zhou Y, Han W. Adv Sci (Weinh). 2022 Apr;9(11):e2103940. doi: 10.1002/advs.202103940. Epub 2022 Jan 25. PubMed |
| Focused ultrasound excites cortical neurons via mechanosensitive calcium accumulation and ion channel amplification. Yoo S, Mittelstein DR, Hurt RC, Lacroix J, Shapiro MG. Nat Commun. 2022 Jan 25;13(1):493. doi: 10.1038/s41467-022-28040-1. PubMed |
| Systematic decomposition of sequence determinants governing CRISPR/Cas9 specificity. Fu R, He W, Dou J, Villarreal OD, Bedford E, Wang H, Hou C, Zhang L, Wang Y, Ma D, Chen Y, Gao X, Depken M, Xu H. Nat Commun. 2022 Jan 25;13(1):474. doi: 10.1038/s41467-022-28028-x. PubMed |
| Parallel functional assessment of m(6)A sites in human endodermal differentiation with base editor screens. Cheng W, Liu F, Ren Z, Chen W, Chen Y, Liu T, Ma Y, Cao N, Wang J. Nat Commun. 2022 Jan 25;13(1):478. doi: 10.1038/s41467-022-28106-0. PubMed |
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Tegowski M, Flamand MN, Meyer KD.
Mol Cell. 2022 Feb 17;82(4):868-878.e10. doi: 10.1016/j.molcel.2021.12.038. Epub 2022 Jan 25.
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| Genome-scale CRISPR screens identify host factors that promote human coronavirus infection. Grodzki M, Bluhm AP, Schaefer M, Tagmount A, Russo M, Sobh A, Rafiee R, Vulpe CD, Karst SM, Norris MH. Genome Med. 2022 Jan 27;14(1):10. doi: 10.1186/s13073-022-01013-1. PubMed |
| Functional Genomic Identification of Predictors of Sensitivity and Mechanisms of Resistance to Multivalent Second-Generation TRAIL-R2 Agonists. Grinkevitch V, Wappett M, Crawford N, Price S, Lees A, McCann C, McAllister K, Prehn J, Young J, Bateson J, Gallagher L, Michaut M, Iyer V, Chatzipli A, Barthorpe S, Ciznadija D, Sloma I, Wesa A, Tice DA, Wessels L, Garnett M, Longley DB, McDermott U, McDade SS. Mol Cancer Ther. 2022 Apr 1;21(4):594-606. doi: 10.1158/1535-7163.MCT-21-0532. PubMed |
| The SH2 domain and kinase activity of JAK2 target JAK2 to centrosome and regulate cell growth and centrosome amplification. Shahi A, Kahle J, Hopkins C, Diakonova M. PLoS One. 2022 Jan 28;17(1):e0261098. doi: 10.1371/journal.pone.0261098. eCollection 2022. PubMed |
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| LncRNAs LCETRL3 and LCETRL4 at chromosome 4q12 diminish EGFR-TKIs efficiency in NSCLC through stabilizing TDP43 and EIF2S1. Li Y, Shen Y, Xie M, Wang B, Wang T, Zeng J, Hua H, Yu J, Yang M. Signal Transduct Target Ther. 2022 Jan 31;7(1):30. doi: 10.1038/s41392-021-00847-2. PubMed |
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| Follistatin promotes LIN28B-mediated supporting cell reprogramming and hair cell regeneration in the murine cochlea. Li XJ, Morgan C, Goff LA, Doetzlhofer A. Sci Adv. 2022 Feb 11;8(6):eabj7651. doi: 10.1126/sciadv.abj7651. Epub 2022 Feb 11. PubMed |
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| RNA sensing via the RIG-I-like receptor LGP2 is essential for the induction of a type I IFN response in ADAR1 deficiency. Stok JE, Oosenbrug T, Ter Haar LR, Gravekamp D, Bromley CP, Zelenay S, Reis E Sousa C, van der Veen AG. EMBO J. 2022 Mar 15;41(6):e109760. doi: 10.15252/embj.2021109760. Epub 2022 Feb 14. PubMed |
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Base editing sensor libraries for high-throughput engineering and functional analysis of cancer-associated single nucleotide variants.
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| Combinatorial Approach of Binary Colloidal Crystals and CRISPR Activation to Improve Induced Pluripotent Stem Cell Differentiation into Neurons. Urrutia-Cabrera D, Hsiang-Chi Liou R, Lin J, Shi Y, Liu K, Hung SSC, Hewitt AW, Wang PY, Ching-Bong Wong R. ACS Appl Mater Interfaces. 2022 Feb 23;14(7):8669-8679. doi: 10.1021/acsami.1c17975. Epub 2022 Feb 15. PubMed |
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| TP53 promotes lineage commitment of human embryonic stem cells through ciliogenesis and sonic hedgehog signaling. Sivakumar S, Qi S, Cheng N, Sathe AA, Kanchwala M, Kumar A, Evers BM, Xing C, Yu H. Cell Rep. 2022 Feb 15;38(7):110395. doi: 10.1016/j.celrep.2022.110395. PubMed |
| A non-catalytic scaffolding activity of hexokinase 2 contributes to EMT and metastasis. Blaha CS, Ramakrishnan G, Jeon SM, Nogueira V, Rho H, Kang S, Bhaskar P, Terry AR, Aissa AF, Frolov MV, Patra KC, Brooks Robey R, Hay N. Nat Commun. 2022 Feb 16;13(1):899. doi: 10.1038/s41467-022-28440-3. PubMed |
| Legionella pneumophila regulates host cell motility by targeting Phldb2 with a 14-3-3zeta-dependent protease effector. Song L, Luo J, Wang H, Huang D, Tan Y, Liu Y, Wang Y, Yu K, Zhang Y, Liu X, Li D, Luo ZQ. Elife. 2022 Feb 17;11. pii: 73220. doi: 10.7554/eLife.73220. PubMed |
| YAP/TAZ drives cell proliferation and tumour growth via a polyamine-eIF5A hypusination-LSD1 axis. Li H, Wu BK, Kanchwala M, Cai J, Wang L, Xing C, Zheng Y, Pan D. Nat Cell Biol. 2022 Mar;24(3):373-383. doi: 10.1038/s41556-022-00848-5. Epub 2022 Feb 17. PubMed |
| Cell migration orchestrates migrasome formation by shaping retraction fibers. Fan C, Shi X, Zhao K, Wang L, Shi K, Liu YJ, Li H, Ji B, Jiu Y. J Cell Biol. 2022 Apr 4;221(4). pii: 213015. doi: 10.1083/jcb.202109168. Epub 2022 Feb 18. PubMed |
| RB1 loss overrides PARP inhibitor sensitivity driven by RNASEH2B loss in prostate cancer. Miao C, Tsujino T, Takai T, Gui F, Tsutsumi T, Sztupinszki Z, Wang Z, Azuma H, Szallasi Z, Mouw KW, Zou L, Kibel AS, Jia L. Sci Adv. 2022 Feb 18;8(7):eabl9794. doi: 10.1126/sciadv.abl9794. Epub 2022 Feb 18. PubMed |
| HOTTIP-dependent R-loop formation regulates CTCF boundary activity and TAD integrity in leukemia. Luo H, Zhu G, Eshelman MA, Fung TK, Lai Q, Wang F, Zeisig BB, Lesperance J, Ma X, Chen S, Cesari N, Cogle C, Chen B, Xu B, Yang FC, So CWE, Qiu Y, Xu M, Huang S. Mol Cell. 2022 Feb 17;82(4):833-851.e11. doi: 10.1016/j.molcel.2022.01.014. PubMed |
| Quantitative Proteomic Analysis of Cervical Cancer Tissues Identifies Proteins Associated With Cancer Progression. Ramirez-Torres A, Gil J, Contreras S, Ramirez G, Valencia-Gonzalez HA, Salazar-Bustamante E, Gomez-Caudillo L, Garcia-Carranca A, Encarnacion-Guevara S. Cancer Genomics Proteomics. 2022 Mar-Apr;19(2):241-258. doi: 10.21873/cgp.20317. PubMed |
| PMS2 variant results in loss of ATPase activity without compromising mismatch repair. D'Arcy BM, Arrington J, Weisman J, McClellan SB, Vandana, Yang Z, Deivanayagam C, Blount J, Prakash A. Mol Genet Genomic Med. 2022 Feb 21:e1908. doi: 10.1002/mgg3.1908. PubMed |
| Genetically encoded BRET-activated photodynamic therapy for the treatment of deep-seated tumors. Shramova EI, Chumakov SP, Shipunova VO, Ryabova AV, Telegin GB, Kabashin AV, Deyev SM, Proshkina GM. Light Sci Appl. 2022 Feb 21;11(1):38. doi: 10.1038/s41377-022-00729-4. PubMed |
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| Melanocortin 1 receptor activation protects against alpha-synuclein pathologies in models of Parkinson's disease. Cai W, Srivastava P, Feng D, Lin Y, Vanderburg CR, Xu Y, Mclean P, Frosch MP, Fisher DE, Schwarzschild MA, Chen X. Mol Neurodegener. 2022 Feb 23;17(1):16. doi: 10.1186/s13024-022-00520-4. PubMed |
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| Enzymatic activity of glycosyltransferase GLT8D1 promotes human glioblastoma cell migration. Ilina EI, Cialini C, Gerloff DL, Duarte Garcia-Escudero M, Jeanty C, Thezenas ML, Lesur A, Puard V, Bernardin F, Moter A, Schuster A, Dieterle M, Golebiewska A, Gerardy JJ, Dittmar G, Niclou SP, Muller T, Mittelbronn M. iScience. 2022 Feb 2;25(2):103842. doi: 10.1016/j.isci.2022.103842. eCollection 2022 Feb 18. PubMed |
| Regulation of influenza A virus infection by Lnc-PINK1-2:5. Pushparaj S, Zhu Z, Huang C, More S, Liang Y, Lin K, Vaddadi K, Liu L. J Cell Mol Med. 2022 Apr;26(8):2285-2298. doi: 10.1111/jcmm.17249. Epub 2022 Feb 24. PubMed |
| SF3B4 promotes ovarian cancer progression by regulating alternative splicing of RAD52. Diao Y, Li Y, Wang Z, Wang S, Li P, Kong B. Cell Death Dis. 2022 Feb 24;13(2):179. doi: 10.1038/s41419-022-04630-1. PubMed |
| ABIN1 is a signal-induced autophagy receptor that attenuates NF-kappaB activation by recognizing linear ubiquitin chains. Shinkawa Y, Imami K, Fuseya Y, Sasaki K, Ohmura K, Ishihama Y, Morinobu A, Iwai K. FEBS Lett. 2022 May;596(9):1147-1164. doi: 10.1002/1873-3468.14323. Epub 2022 Mar 4. PubMed |
| Potential Anti-SARS-CoV-2 Activity of Pentosan Polysulfate and Mucopolysaccharide Polysulfate. Zhang F, He P, Rodrigues AL, Jeske W, Tandon R, Bates JT, Bierdeman MA, Fareed J, Dordick J, Linhardt RJ. Pharmaceuticals (Basel). 2022 Feb 21;15(2). pii: ph15020258. doi: 10.3390/ph15020258. PubMed |
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| Plasmalogens, the Vinyl Ether-Linked Glycerophospholipids, Enhance Learning and Memory by Regulating Brain-Derived Neurotrophic Factor. Hossain MS, Mawatari S, Fujino T. Front Cell Dev Biol. 2022 Feb 9;10:828282. doi: 10.3389/fcell.2022.828282. eCollection 2022. PubMed |
Mutation-specific reporter for optimization and enrichment of prime editing.
Schene IF, Joore IP, Baijens JHL, Stevelink R, Kok G, Shehata S, Ilcken EF, Nieuwenhuis ECM, Bolhuis DP, van Rees RCM, Spelier SA, van der Doef HPJ, Beekman JM, Houwen RHJ, Nieuwenhuis EES, Fuchs SA.
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iScience. 2022 Feb 8;25(3):103891. doi: 10.1016/j.isci.2022.103891. eCollection 2022 Mar 18.
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Legut M, Gajic Z, Guarino M, Daniloski Z, Rahman JA, Xue X, Lu C, Lu L, Mimitou EP, Hao S, Davoli T, Diefenbach C, Smibert P, Sanjana NE.
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Targeting DNA polymerase to DNA double-strand breaks reduces DNA deletion size and increases templated insertions generated by CRISPR/Cas9.
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Nucleic Acids Res. 2022 Mar 22. pii: 6552087. doi: 10.1093/nar/gkac186.
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| A Comparative Transcriptomic Analysis Reveals That HSP90AB1 Is Involved in the Immune and Inflammatory Responses to Porcine Deltacoronavirus Infection. Zhao Y, Chen R, Xiao D, Zhang L, Song D, Wen Y, Wu R, Zhao Q, Du S, Wen X, Cao S, Huang X. Int J Mol Sci. 2022 Mar 18;23(6). pii: ijms23063280. doi: 10.3390/ijms23063280. PubMed |
| Integrative network analysis of early-stage lung adenocarcinoma identifies aurora kinase inhibition as interceptor of invasion and progression. Yoo S, Sinha A, Yang D, Altorki NK, Tandon R, Wang W, Chavez D, Lee E, Patel AS, Sato T, Kong R, Ding B, Schadt EE, Watanabe H, Massion PP, Borczuk AC, Zhu J, Powell CA. Nat Commun. 2022 Mar 24;13(1):1592. doi: 10.1038/s41467-022-29230-7. PubMed |
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| Study of Viral Photoinactivation by UV-C Light and Photosensitizer Using a Pseudotyped Model. Sadraeian M, Junior FFP, Miranda M, Galinskas J, Fernandes RS, da Cruz EF, Fu L, Zhang L, Diaz RS, Cabral-Miranda G, Guimaraes FEG. Pharmaceutics. 2022 Mar 21;14(3). pii: pharmaceutics14030683. doi: 10.3390/pharmaceutics14030683. PubMed |
| Identification of SARS-CoV-2 Spike Palmitoylation Inhibitors That Results in Release of Attenuated Virus with Reduced Infectivity. Ramadan AA, Mayilsamy K, McGill AR, Ghosh A, Giulianotti MA, Donow HM, Mohapatra SS, Mohapatra S, Chandran B, Deschenes RJ, Roy A. Viruses. 2022 Mar 4;14(3). pii: v14030531. doi: 10.3390/v14030531. PubMed |
| CRISPR activation screen identifies BCL-2 proteins and B3GNT2 as drivers of cancer resistance to T cell-mediated cytotoxicity. Joung J, Kirchgatterer PC, Singh A, Cho JH, Nety SP, Larson RC, Macrae RK, Deasy R, Tseng YY, Maus MV, Zhang F. Nat Commun. 2022 Mar 25;13(1):1606. doi: 10.1038/s41467-022-29205-8. PubMed |
| Guide RNAs containing universal bases enable Cas9/Cas12a recognition of polymorphic sequences. Krysler AR, Cromwell CR, Tu T, Jovel J, Hubbard BP. Nat Commun. 2022 Mar 25;13(1):1617. doi: 10.1038/s41467-022-29202-x. PubMed |
| Efficient silencing of hepatitis B virus S gene through CRISPR-mediated base editing. Zhou H, Wang X, Steer CJ, Song G, Niu J. Hepatol Commun. 2022 Jul;6(7):1652-1663. doi: 10.1002/hep4.1933. Epub 2022 Mar 26. PubMed |
| PD-LI promotes rear retraction during persistent cell migration by altering integrin beta4 dynamics. Wang M, Xiong C, Mercurio AM. J Cell Biol. 2022 May 2;221(5):e202108083. doi: 10.1083/jcb.202108083. Epub 2022 Mar 28. PubMed |
| Selective cleavage of ncRNA and antiviral activity by RNase2/EDN in THP1-induced macrophages. Lu L, Li J, Wei R, Guidi I, Cozzuto L, Ponomarenko J, Prats-Ejarque G, Boix E. Cell Mol Life Sci. 2022 Mar 26;79(4):209. doi: 10.1007/s00018-022-04229-x. PubMed |
| CRISPR Guide RNA Library Screens in Human Induced Pluripotent Stem Cells. Zhou Y, Fu Q, Shi H, Zhou G. Methods Mol Biol. 2022;2549:233-257. doi: 10.1007/7651_2021_455. PubMed |
| Ricolinostat enhances adavosertibinduced mitotic catastrophe in TP53mutated head and neck squamous cell carcinoma cells. Miyake K, Takano N, Kazama H, Kikuchi H, Hiramoto M, Tsukahara K, Miyazawa K. Int J Oncol. 2022 May;60(5). pii: 54. doi: 10.3892/ijo.2022.5344. Epub 2022 Mar 29. PubMed |
| FOXK2 promotes ovarian cancer stemness by regulating the unfolded protein response pathway. Zhang Y, Wang Y, Zhao G, Tanner EJ, Adli M, Matei D. J Clin Invest. 2022 May 16;132(10). pii: 151591. doi: 10.1172/JCI151591. PubMed |
| ESCRT-I fuels lysosomal degradation to restrict TFEB/TFE3 signaling via the Rag-mTORC1 pathway. Wrobel M, Cendrowski J, Szymanska E, Grebowicz-Maciukiewicz M, Budick-Harmelin N, Macias M, Szybinska A, Mazur M, Kolmus K, Goryca K, Dabrowska M, Paziewska A, Mikula M, Miaczynska M. Life Sci Alliance. 2022 Mar 30;5(7). pii: 5/7/e202101239. doi: 10.26508/lsa.202101239. Print 2022 Jul. PubMed |
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| Synapse topology and downmodulation events determine the functional outcome of anti-CD19 T cell-redirecting strategies. Ramirez-Fernandez A, Aguilar-Sopena O, Diez-Alonso L, Segura-Tudela A, Dominguez-Alonso C, Roda-Navarro P, Alvarez-Vallina L, Blanco B. Oncoimmunology. 2022 Mar 23;11(1):2054106. doi: 10.1080/2162402X.2022.2054106. eCollection 2022. PubMed |
Sensitivity of VHL mutant kidney cancers to HIF2 inhibitors does not require an intact p53 pathway.
Stransky LA, Vigeant SM, Huang B, West D, Denize T, Walton E, Signoretti S, Kaelin WG Jr.
Proc Natl Acad Sci U S A. 2022 Apr 5;119(14):e2120403119. doi: 10.1073/pnas.2120403119. Epub 2022 Mar 31.
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| Folliculin promotes substrate-selective mTORC1 activity by activating RagC to recruit TFE3. Li K, Wada S, Gosis BS, Thorsheim C, Loose P, Arany Z. PLoS Biol. 2022 Mar 31;20(3):e3001594. doi: 10.1371/journal.pbio.3001594. eCollection 2022 Mar. PubMed |
| High-throughput identification of autoantibodies that target the human exoproteome. Wang EY, Dai Y, Rosen CE, Schmitt MM, Dong MX, Ferre EMN, Liu F, Yang Y, Gonzalez-Hernandez JA, Meffre E, Hinchcliff M, Koumpouras F, Lionakis MS, Ring AM. Cell Rep Methods. 2022 Feb 28;2(2). doi: 10.1016/j.crmeth.2022.100172. Epub 2022 Feb 17. PubMed |
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| PRMT5 Interacting Partners and Substrates in Oligodendrocyte Lineage Cells. Dansu DK, Liang J, Selcen I, Zheng H, Moore DF, Casaccia P. Front Cell Neurosci. 2022 Mar 17;16:820226. doi: 10.3389/fncel.2022.820226. eCollection 2022. PubMed |
| A functional SNP rs895819 on pre-miR-27a is associated with bipolar disorder by targeting NCAM1. Yang Y, Lu W, Ning M, Zhou X, Wan X, Mi Q, Yang X, Zhang D, Zhang Y, Jiang B, He L, Liu J, Zou Y. Commun Biol. 2022 Apr 4;5(1):309. doi: 10.1038/s42003-022-03263-6. PubMed |
| SARS-CoV-2 antigen exposure history shapes phenotypes and specificity of memory CD8(+) T cells. Minervina AA, Pogorelyy MV, Kirk AM, Crawford JC, Allen EK, Chou CH, Mettelman RC, Allison KJ, Lin CY, Brice DC, Zhu X, Vegesana K, Wu G, Trivedi S, Kottapalli P, Darnell D, McNeely S, Olsen SR, Schultz-Cherry S, Estepp JH, McGargill MA, Wolf J, Thomas PG. Nat Immunol. 2022 May;23(5):781-790. doi: 10.1038/s41590-022-01184-4. Epub 2022 Apr 5. PubMed |
| Enhancement of prime editing via xrRNA motif-joined pegRNA. Zhang G, Liu Y, Huang S, Qu S, Cheng D, Yao Y, Ji Q, Wang X, Huang X, Liu J. Nat Commun. 2022 Apr 6;13(1):1856. doi: 10.1038/s41467-022-29507-x. PubMed |
| Lupus enhancer risk variant causes dysregulation of IRF8 through cooperative lncRNA and DNA methylation machinery. Zhou T, Zhu X, Ye Z, Wang YF, Yao C, Xu N, Zhou M, Ma J, Qin Y, Shen Y, Tang Y, Yin Z, Xu H, Zhang Y, Zang X, Ding H, Yang W, Guo Y, Harley JB, Namjou B, Kaufman KM, Kottyan LC, Weirauch MT, Hou G, Shen N. Nat Commun. 2022 Apr 6;13(1):1855. doi: 10.1038/s41467-022-29514-y. PubMed |
| Ca(2+)-activated sphingomyelin scrambling and turnover mediate ESCRT-independent lysosomal repair. Niekamp P, Scharte F, Sokoya T, Vittadello L, Kim Y, Deng Y, Sudhoff E, Hilderink A, Imlau M, Clarke CJ, Hensel M, Burd CG, Holthuis JCM. Nat Commun. 2022 Apr 6;13(1):1875. doi: 10.1038/s41467-022-29481-4. PubMed |
| DAPLE orchestrates apical actomyosin assembly from junctional polarity complexes. Marivin A, Ho RX, Garcia-Marcos M. J Cell Biol. 2022 May 2;221(5):e202111002. doi: 10.1083/jcb.202111002. Epub 2022 Apr 7. PubMed |
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| Promoter and enhancer RNAs regulate chromatin reorganization and activation of miR-10b/HOXD locus, and neoplastic transformation in glioma. Deforzh E, Uhlmann EJ, Das E, Galitsyna A, Arora R, Saravanan H, Rabinovsky R, Wirawan AD, Teplyuk NM, El Fatimy R, Perumalla S, Jairam A, Wei Z, Mirny L, Krichevsky AM. Mol Cell. 2022 May 19;82(10):1894-1908.e5. doi: 10.1016/j.molcel.2022.03.018. Epub 2022 Apr 6. PubMed |
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| Phenotypic and molecular states of IDH1 mutation-induced CD24-positive glioma stem-like cells. Haddock S, Alban TJ, Turcan S, Husic H, Rosiek E, Ma X, Wang Y, Bale T, Desrichard A, Makarov V, Monette S, Wu W, Gardner R, Manova K, Boire A, Chan TA. Neoplasia. 2022 Jun;28:100790. doi: 10.1016/j.neo.2022.100790. Epub 2022 Apr 7. PubMed |
| Swine Interferon-Inducible Transmembrane Proteins Potently Inhibit African Swine Fever Virus Replication. Cai S, Zheng Z, Cheng J, Zhong L, Shao R, Zheng F, Lai Z, Ou J, Xu L, Zhou P, Lu G, Zhang G. Front Immunol. 2022 Mar 25;13:827709. doi: 10.3389/fimmu.2022.827709. eCollection 2022. PubMed |
| Anti-Fungal Drug Anidulafungin Inhibits SARS-CoV-2 Spike-Induced Syncytia Formation by Targeting ACE2-Spike Protein Interaction. Ahamad S, Ali H, Secco I, Giacca M, Gupta D. Front Genet. 2022 Mar 25;13:866474. doi: 10.3389/fgene.2022.866474. eCollection 2022. PubMed |
| PINCH-1 promotes IGF-1 receptor expression and skin cancer progression through inhibition of the GRB10-NEDD4 complex. Wang X, Wang R, Jiang K, Zhu M, Guo L, Wu C. Theranostics. 2022 Feb 28;12(6):2613-2630. doi: 10.7150/thno.70744. eCollection 2022. PubMed |
| Inhibition of MACC1-Induced Metastasis in Esophageal and Gastric Adenocarcinomas. Treese C, Werchan J, von Winterfeld M, Berg E, Hummel M, Timm L, Rau B, Daberkow O, Walther W, Daum S, Kobelt D, Stein U. Cancers (Basel). 2022 Mar 31;14(7):1773. doi: 10.3390/cancers14071773. PubMed |
| ATRX-Deficient High-Grade Glioma Cells Exhibit Increased Sensitivity to RTK and PDGFR Inhibitors. Pladevall-Morera D, Castejon-Grinan M, Aguilera P, Gaardahl K, Ingham A, Brosnan-Cashman JA, Meeker AK, Lopez-Contreras AJ. Cancers (Basel). 2022 Mar 31;14(7). pii: cancers14071790. doi: 10.3390/cancers14071790. PubMed |
| Enhancer RNA Transcription Is Essential for a Novel CSF1 Enhancer in Triple-Negative Breast Cancer. Lewis MW, Wisniewska K, King CM, Li S, Coffey A, Kelly MR, Regner MJ, Franco HL. Cancers (Basel). 2022 Apr 6;14(7). pii: cancers14071852. doi: 10.3390/cancers14071852. PubMed |
| Baicalein Activates Parkin-Dependent Mitophagy through NDP52 and OPTN. Ke PY, Chang CW, Hsiao YC. Cells. 2022 Mar 28;11(7). pii: cells11071132. doi: 10.3390/cells11071132. PubMed |
| Genome-wide CRISPR screen identifies PRC2 and KMT2D-COMPASS as regulators of distinct EMT trajectories that contribute differentially to metastasis. Zhang Y, Donaher JL, Das S, Li X, Reinhardt F, Krall JA, Lambert AW, Thiru P, Keys HR, Khan M, Hofree M, Wilson MM, Yedier-Bayram O, Lack NA, Onder TT, Bagci-Onder T, Tyler M, Tirosh I, Regev A, Lees JA, Weinberg RA. Nat Cell Biol. 2022 Apr;24(4):554-564. doi: 10.1038/s41556-022-00877-0. Epub 2022 Apr 11. PubMed |
| Circadian Regulator CLOCK Drives Immunosuppression in Glioblastoma. Xuan W, Hsu WH, Khan F, Dunterman M, Pang L, Wainwright DA, Ahmed AU, Heimberger AB, Lesniak MS, Chen P. Cancer Immunol Res. 2022 Jun 3;10(6):770-784. doi: 10.1158/2326-6066.CIR-21-0559. PubMed |
| Sinomenine hydrochloride suppresses the stemness of breast cancer stem cells by inhibiting Wnt signaling pathway through down-regulation of WNT10B. Li X, Chen W, Huang L, Zhu M, Zhang H, Si Y, Li H, Luo Q, Yu B. Pharmacol Res. 2022 May;179:106222. doi: 10.1016/j.phrs.2022.106222. Epub 2022 Apr 9. PubMed |
| The smoothened agonist SAG reduces mitochondrial dysfunction and neurotoxicity of frataxin-deficient astrocytes. Vicente-Acosta A, Gimenez-Cassina A, Diaz-Nido J, Loria F. J Neuroinflammation. 2022 Apr 12;19(1):93. doi: 10.1186/s12974-022-02442-w. PubMed |
| Cadherin-11 Influences Differentiation in Human Mesenchymal Stem Cells by Regulating the Extracellular Matrix Via the TGFbeta1 Pathway. Passanha FR, Geuens T, LaPointe VLS. Stem Cells. 2022 Jul 27;40(7):669-677. doi: 10.1093/stmcls/sxac026. PubMed |
| Mitolysosome exocytosis, a mitophagy-independent mitochondrial quality control in flunarizine-induced parkinsonism-like symptoms. Bao F, Zhou L, Zhou R, Huang Q, Chen J, Zeng S, Wu Y, Yang L, Qian S, Wang M, He X, Liang S, Qi J, Xiang G, Long Q, Guo J, Ying Z, Zhou Y, Zhao Q, Zhang J, Zhang D, Sun W, Gao M, Wu H, Zhao Y, Nie J, Li M, Chen Q, Chen J, Zhang X, Pan G, Zhang H, Li M, Tian M, Liu X. Sci Adv. 2022 Apr 15;8(15):eabk2376. doi: 10.1126/sciadv.abk2376. Epub 2022 Apr 13. PubMed |
| Nuclear microRNAs release paused Pol II via the DDX21-CDK9 complex. Ohno SI, Oikawa K, Tsurui T, Harada Y, Ono K, Tateishi M, Mirza A, Takanashi M, Kanekura K, Nagase K, Shimada Y, Kudo Y, Ikeda N, Ochiya T, Wang X, Kuroda M. Cell Rep. 2022 Apr 12;39(2):110673. doi: 10.1016/j.celrep.2022.110673. PubMed |
| Synaptic vesicle binding of alpha-synuclein is modulated by beta- and gamma-synucleins. Carnazza KE, Komer LE, Xie YX, Pineda A, Briano JA, Gao V, Na Y, Ramlall T, Buchman VL, Eliezer D, Sharma M, Burre J. Cell Rep. 2022 Apr 12;39(2):110675. doi: 10.1016/j.celrep.2022.110675. PubMed |
| The nuclear receptor ERR cooperates with the cardiogenic factor GATA4 to orchestrate cardiomyocyte maturation. Sakamoto T, Batmanov K, Wan S, Guo Y, Lai L, Vega RB, Kelly DP. Nat Commun. 2022 Apr 13;13(1):1991. doi: 10.1038/s41467-022-29733-3. PubMed |
| Aberrant R-loop-induced replication stress in MED12-mutant uterine fibroids. Muralimanoharan S, Shamby R, Stansbury N, Schenken R, de la Pena Avalos B, Javanmardi S, Dray E, Sung P, Boyer TG. Sci Rep. 2022 Apr 13;12(1):6169. doi: 10.1038/s41598-022-10188-x. PubMed |
A Single Transcript Knockdown-Replacement Strategy Employing 5' UTR Secondary Structures to Precisely Titrate Rescue Protein Translation.
Millette MM, Holland ED, Tenpas TJ, Dent EW.
Front Genome Ed. 2022 Mar 28;4:803375. doi: 10.3389/fgeed.2022.803375. eCollection 2022.
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| SLC35B2 Acts in a Dual Role in the Host Sulfation Required for EV71 Infection. Guo D, Yu X, Wang D, Li Z, Zhou Y, Xu G, Yuan B, Qin Y, Chen M. J Virol. 2022 May 11;96(9):e0204221. doi: 10.1128/jvi.02042-21. Epub 2022 Apr 14. PubMed |
Inducible CRISPR activation screen for interferon-stimulated genes identifies OAS1 as a SARS-CoV-2 restriction factor.
Danziger O, Patel RS, DeGrace EJ, Rosen MR, Rosenberg BR.
PLoS Pathog. 2022 Apr 14;18(4):e1010464. doi: 10.1371/journal.ppat.1010464. eCollection 2022 Apr.
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| Ovarian cancer immunogenicity is governed by a narrow subset of progenitor tissue-resident memory T cells. Anadon CM, Yu X, Hanggi K, Biswas S, Chaurio RA, Martin A, Payne KK, Mandal G, Innamarato P, Harro CM, Mine JA, Sprenger KB, Cortina C, Powers JJ, Costich TL, Perez BA, Gatenbee CD, Prabhakaran S, Marchion D, Heemskerk MHM, Curiel TJ, Anderson AR, Wenham RM, Rodriguez PC, Conejo-Garcia JR. Cancer Cell. 2022 May 9;40(5):545-557.e13. doi: 10.1016/j.ccell.2022.03.008. Epub 2022 Apr 14. PubMed |
| MAFB promotes the malignant phenotypes by IGFBP6 in esophageal squamous cell carcinomas. Zhang S, Gong T, Nan Y, Feng R, Liu Z, Chen H. Exp Cell Res. 2022 Jul 1;416(1):113158. doi: 10.1016/j.yexcr.2022.113158. Epub 2022 Apr 14. PubMed |
| Synthetic carbohydrate-binding agents neutralize SARS-CoV-2 by inhibiting binding of the spike protein to ACE2. Francesconi O, Donnici L, Fragai M, Pesce E, Bombaci M, Fasciani A, Manganaro L, Conti M, Grifantini R, De Francesco R, Nativi C, Roelens S. iScience. 2022 May 20;25(5):104239. doi: 10.1016/j.isci.2022.104239. Epub 2022 Apr 11. PubMed |
| m6A and YTHDF proteins contribute to the localization of select neuronal mRNAs. Flamand MN, Meyer KD. Nucleic Acids Res. 2022 May 6;50(8):4464-4483. doi: 10.1093/nar/gkac251. PubMed |
| DENR controls JAK2 translation to induce PD-L1 expression for tumor immune evasion. Chen B, Hu J, Hu X, Chen H, Bao R, Zhou Y, Ye Y, Zhan M, Cai W, Li H, Li HB. Nat Commun. 2022 Apr 19;13(1):2059. doi: 10.1038/s41467-022-29754-y. PubMed |
| USP25 promotes pathological HIF-1-driven metabolic reprogramming and is a potential therapeutic target in pancreatic cancer. Nelson JK, Thin MZ, Evan T, Howell S, Wu M, Almeida B, Legrave N, Koenis DS, Koifman G, Sugimoto Y, Llorian Sopena M, MacRae J, Nye E, Howell M, Snijders AP, Prachalias A, Zen Y, Sarker D, Behrens A. Nat Commun. 2022 Apr 19;13(1):2070. doi: 10.1038/s41467-022-29684-9. PubMed |
| A leukemia-protective germline variant mediates chromatin module formation via transcription factor nucleation. Llimos G, Gardeux V, Koch U, Kribelbauer JF, Hafner A, Alpern D, Pezoldt J, Litovchenko M, Russeil J, Dainese R, Moia R, Mahmoud AM, Rossi D, Gaidano G, Plass C, Lutsik P, Gerhauser C, Waszak SM, Boettiger A, Radtke F, Deplancke B. Nat Commun. 2022 Apr 19;13(1):2042. doi: 10.1038/s41467-022-29625-6. PubMed |
| Inhibition of the succinyl dehydrogenase complex in acute myeloid leukemia leads to a lactate-fuelled respiratory metabolic vulnerability. Erdem A, Marin S, Pereira-Martins DA, Geugien M, Cunningham A, Pruis MG, Weinhauser I, Gerding A, Bakker BM, Wierenga ATJ, Rego EM, Huls G, Cascante M, Schuringa JJ. Nat Commun. 2022 Apr 19;13(1):2013. doi: 10.1038/s41467-022-29639-0. PubMed |
| A loss-of-adhesion CRISPR-Cas9 screening platform to identify cell adhesion-regulatory proteins and signaling pathways. de Rooij MFM, Thus YJ, Swier N, Beijersbergen RL, Pals ST, Spaargaren M. Nat Commun. 2022 Apr 19;13(1):2136. doi: 10.1038/s41467-022-29835-y. PubMed |
| Mitotic Spindle Positioning (MISP) is an actin bundler that selectively stabilizes the rootlets of epithelial microvilli. Morales EA, Arnaiz C, Krystofiak ES, Zanic M, Tyska MJ. Cell Rep. 2022 Apr 19;39(3):110692. doi: 10.1016/j.celrep.2022.110692. PubMed |
| The caspase-2 substrate p54nrb exhibits a multifaceted role in tumor cell death susceptibility via gene regulatory functions. Eichler M, Distler U, Nasrullah U, Krishnan A, Kaulich M, Husnjak K, Eberhardt W, Rajalingam K, Tenzer S, Pfeilschifter J, Imre G. Cell Death Dis. 2022 Apr 20;13(4):386. doi: 10.1038/s41419-022-04829-2. PubMed |
| TRMT6/61A-dependent base methylation of tRNA-derived fragments regulates gene-silencing activity and the unfolded protein response in bladder cancer. Su Z, Monshaugen I, Wilson B, Wang F, Klungland A, Ougland R, Dutta A. Nat Commun. 2022 Apr 20;13(1):2165. doi: 10.1038/s41467-022-29790-8. PubMed |
| BRAF Inhibitor Resistance Confers Increased Sensitivity to Mitotic Inhibitors. Misek SA, Foda BM, Dexheimer TS, Akram M, Conrad SE, Schmidt JC, Neubig RR, Gallo KA. Front Oncol. 2022 Apr 4;12:766794. doi: 10.3389/fonc.2022.766794. eCollection 2022. PubMed |
| PRC1 and RACGAP1 are Diagnostic Biomarkers of Early HCC and PRC1 Drives Self-Renewal of Liver Cancer Stem Cells. Liao S, Wang K, Zhang L, Shi G, Wang Z, Chen Z, Zhu P, He Q. Front Cell Dev Biol. 2022 Apr 4;10:864051. doi: 10.3389/fcell.2022.864051. eCollection 2022. PubMed |
| Secretory autophagy maintains proteostasis upon lysosome inhibition. Solvik TA, Nguyen TA, Tony Lin YH, Marsh T, Huang EJ, Wiita AP, Debnath J, Leidal AM. J Cell Biol. 2022 Jun 6;221(6). pii: 213172. doi: 10.1083/jcb.202110151. Epub 2022 Apr 21. PubMed |
| Multilayered omics reveal sex- and depot-dependent adipose progenitor cell heterogeneity. Shan B, Barker CS, Shao M, Zhang Q, Gupta RK, Wu Y. Cell Metab. 2022 May 3;34(5):783-799.e7. doi: 10.1016/j.cmet.2022.03.012. Epub 2022 Apr 20. PubMed |
| Cellular abundance of sodium phosphate cotransporter SLC20A1/PiT1 and phosphate uptake are controlled post-transcriptionally by ESCRT. Zechner C, Henne WM, Sathe AA, Xing C, Hernandez G, Sun S, Cheong MC. J Biol Chem. 2022 Jun;298(6):101945. doi: 10.1016/j.jbc.2022.101945. Epub 2022 Apr 18. PubMed |
| PD-L1 signaling selectively regulates T cell lymphatic transendothelial migration. Piao W, Li L, Saxena V, Iyyathurai J, Lakhan R, Zhang Y, Lape IT, Paluskievicz C, Hippen KL, Lee Y, Silverman E, Shirkey MW, Riella LV, Blazar BR, Bromberg JS. Nat Commun. 2022 Apr 21;13(1):2176. doi: 10.1038/s41467-022-29930-0. PubMed |
| HMCES protects immunoglobulin genes specifically from deletions during somatic hypermutation. Wu L, Shukla V, Yadavalli AD, Dinesh RK, Xu D, Rao A, Schatz DG. Genes Dev. 2022 Apr 1;36(7-8):433-450. doi: 10.1101/gad.349438.122. Epub 2022 Apr 21. PubMed |
| Active endogenous retroviral elements in human pluripotent stem cells play a role in regulating host gene expression. Zhang T, Zheng R, Li M, Yan C, Lan X, Tong B, Lu P, Jiang W. Nucleic Acids Res. 2022 May 20;50(9):4959-4973. doi: 10.1093/nar/gkac265. PubMed |
| SOD1 mediates lysosome-to-mitochondria communication and its dysregulation by amyloid-beta oligomers. Norambuena A, Sun X, Wallrabe H, Cao R, Sun N, Pardo E, Shivange N, Wang DB, Post LA, Ferris HA, Hu S, Periasamy A, Bloom GS. Neurobiol Dis. 2022 Jul;169:105737. doi: 10.1016/j.nbd.2022.105737. Epub 2022 Apr 20. PubMed |
| Histone Demethylase KDM5C Drives Prostate Cancer Progression by Promoting EMT. Lemster AL, Sievers E, Pasternack H, Lazar-Karsten P, Klumper N, Sailer V, Offermann A, Bragelmann J, Perner S, Kirfel J. Cancers (Basel). 2022 Apr 8;14(8). pii: cancers14081894. doi: 10.3390/cancers14081894. PubMed |
| Developing all-in-one virus-like particles for Cas9 mRNA/single guide RNA co-delivery and aptamer-containing lentiviral vectors for improved gene expression. Yadav M, Atala A, Lu B. Int J Biol Macromol. 2022 Jun 1;209(Pt A):1260-1270. doi: 10.1016/j.ijbiomac.2022.04.114. Epub 2022 Apr 22. PubMed |
| A protocol for CRISPR-mediated activation and repression of human endogenous retroviruses in human pluripotent stem cells. Nair VP, Mayer J, Vincendeau M. STAR Protoc. 2022 Apr 12;3(2):101281. doi: 10.1016/j.xpro.2022.101281. eCollection 2022 Jun 17. PubMed |
| lncRNA-H19 in Fibroblasts Promotes Wound Healing in Diabetes. Yu P, Guo J, Li J, Shi X, Xu N, Jiang Y, Chen W, Hu Q. Diabetes. 2022 Jul 1;71(7):1562-1578. doi: 10.2337/db21-0724. PubMed |
| Leukemia/lymphoma-related factor (LRF) or osteoclast zinc finger protein (OCZF) overexpression promotes osteoclast survival by increasing Bcl-xl mRNA: A novel regulatory mechanism mediated by the RNA binding protein SAM68. Xu X, Shobuike T, Shiraki M, Kamohara A, Hirata H, Murayama M, Mawatari D, Ueno M, Morimoto T, Kukita T, Mawatari M, Kukita A. Lab Invest. 2022 Sep;102(9):1000-1010. doi: 10.1038/s41374-022-00792-w. Epub 2022 Apr 26. PubMed |
| A critical ETV4/Twist1/Vimentin axis in Ha-RAS-induced aggressive breast cancer. Liu W, Gajendran B, Sample KM, Wang C, Hu A, Chen B, Li Y, Zacksenhaus E, Ben-David Y. Cancer Gene Ther. 2022 Apr 27. pii: 10.1038/s41417-022-00471-4. doi: 10.1038/s41417-022-00471-4. PubMed |
| MYCN mediates cysteine addiction and sensitizes neuroblastoma to ferroptosis. Alborzinia H, Florez AF, Kreth S, Bruckner LM, Yildiz U, Gartlgruber M, Odoni DI, Poschet G, Garbowicz K, Shao C, Klein C, Meier J, Zeisberger P, Nadler-Holly M, Ziehm M, Paul F, Burhenne J, Bell E, Shaikhkarami M, Wurth R, Stainczyk SA, Wecht EM, Kreth J, Buttner M, Ishaque N, Schlesner M, Nicke B, Stresemann C, Llamazares-Prada M, Reiling JH, Fischer M, Amit I, Selbach M, Herrmann C, Wolfl S, Henrich KO, Hofer T, Trumpp A, Westermann F. Nat Cancer. 2022 Apr;3(4):471-485. doi: 10.1038/s43018-022-00355-4. Epub 2022 Apr 28. PubMed |
Endomembranes promote chromosome missegregation by ensheathing misaligned chromosomes.
Ferrandiz N, Downie L, Starling GP, Royle SJ.
J Cell Biol. 2022 Jun 6;221(6). pii: 213189. doi: 10.1083/jcb.202203021. Epub 2022 Apr 29.
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| Endogenous pannexin1 channels form functional intercellular cell-cell channels with characteristic voltage-dependent properties. Palacios-Prado N, Soto PA, Lopez X, Choi EJ, Marquez-Miranda V, Rojas M, Duarte Y, Lee J, Gonzalez-Nilo FD, Saez JC. Proc Natl Acad Sci U S A. 2022 May 3;119(18):e2202104119. doi: 10.1073/pnas.2202104119. Epub 2022 Apr 29. PubMed |
| Protein Tyrosine Phosphatase Receptor Type D Regulates Neuropathic Pain After Nerve Injury via the STING-IFN-I Pathway. Sun C, Wu G, Zhang Z, Cao R, Cui S. Front Mol Neurosci. 2022 Apr 14;15:859166. doi: 10.3389/fnmol.2022.859166. eCollection 2022. PubMed |
| In vitro and in vivo assay of the ER lipid scramblase TMEM41B. Wu L, Liu L, Xu B, Huang D, Chen XW. STAR Protoc. 2022 Apr 19;3(2):101333. doi: 10.1016/j.xpro.2022.101333. eCollection 2022 Jun 17. PubMed |
| Mechanism of Erastin-Induced Ferroptosis in MDA-MB-231 Human Breast Cancer Cells: Evidence for a Critical Role of Protein Disulfide Isomerase. Wang H, Wang P, Zhu BT. Mol Cell Biol. 2022 Jun 16;42(6):e0052221. doi: 10.1128/mcb.00522-21. Epub 2022 May 2. PubMed |
| MOZ and Menin-MLL Complexes Are Complementary Regulators of Chromatin Association and Transcriptional Output in Gastrointestinal Stromal Tumor. Hemming ML, Benson MR, Loycano MA, Anderson JA, Andersen JL, Taddei ML, Krivtsov AV, Aubrey BJ, Cutler JA, Hatton C, Sicinska E, Armstrong SA. Cancer Discov. 2022 Jul 6;12(7):1804-1823. doi: 10.1158/2159-8290.CD-21-0646. PubMed |
| Transcription Factor 4 loss-of-function is associated with deficits in progenitor proliferation and cortical neuron content. Papes F, Camargo AP, de Souza JS, Carvalho VMA, Szeto RA, LaMontagne E, Teixeira JR, Avansini SH, Sanchez-Sanchez SM, Nakahara TS, Santo CN, Wu W, Yao H, Araujo BMP, Velho PENF, Haddad GG, Muotri AR. Nat Commun. 2022 May 2;13(1):2387. doi: 10.1038/s41467-022-29942-w. PubMed |
| A T cell resilience model associated with response to immunotherapy in multiple tumor types. Zhang Y, Vu T, Palmer DC, Kishton RJ, Gong L, Huang J, Nguyen T, Chen Z, Smith C, Livak F, Paul R, Day CP, Wu C, Merlino G, Aldape K, Guan XY, Jiang P. Nat Med. 2022 Jul;28(7):1421-1431. doi: 10.1038/s41591-022-01799-y. Epub 2022 May 2. PubMed |
| Genome-Wide Knockout Screen Identifies Human Sialomucin CD164 as an Essential Entry Factor for Lymphocytic Choriomeningitis Virus. Liu J, Knopp KA, Rackaityte E, Wang CY, Laurie MT, Sunshine S, Puschnik AS, DeRisi JL. mBio. 2022 Jun 28;13(3):e0020522. doi: 10.1128/mbio.00205-22. Epub 2022 May 3. PubMed |
| Discovery and functional assessment of a novel adipocyte population driven by intracellular Wnt/beta-catenin signaling in mammals. Liu Z, Chen T, Zhang S, Yang T, Gong Y, Deng HW, Bai D, Tian W, Chen Y. Elife. 2022 May 3;11. pii: 77740. doi: 10.7554/eLife.77740. PubMed |
| Targeted epigenomic editing ameliorates adult anxiety and excessive drinking after adolescent alcohol exposure. Bohnsack JP, Zhang H, Wandling GM, He D, Kyzar EJ, Lasek AW, Pandey SC. Sci Adv. 2022 May 6;8(18):eabn2748. doi: 10.1126/sciadv.abn2748. Epub 2022 May 4. PubMed |
| Patient-derived micro-organospheres enable clinical precision oncology. Ding S, Hsu C, Wang Z, Natesh NR, Millen R, Negrete M, Giroux N, Rivera GO, Dohlman A, Bose S, Rotstein T, Spiller K, Yeung A, Sun Z, Jiang C, Xi R, Wilkin B, Randon PM, Williamson I, Nelson DA, Delubac D, Oh S, Rupprecht G, Isaacs J, Jia J, Chen C, Shen JP, Kopetz S, McCall S, Smith A, Gjorevski N, Walz AC, Antonia S, Marrer-Berger E, Clevers H, Hsu D, Shen X. Cell Stem Cell. 2022 Jun 2;29(6):905-917.e6. doi: 10.1016/j.stem.2022.04.006. Epub 2022 May 3. PubMed |
| Identification of DAXX as a restriction factor of SARS-CoV-2 through a CRISPR/Cas9 screen. Mac Kain A, Maarifi G, Aicher SM, Arhel N, Baidaliuk A, Munier S, Donati F, Vallet T, Tran QD, Hardy A, Chazal M, Porrot F, OhAinle M, Carlson-Stevermer J, Oki J, Holden K, Zimmer G, Simon-Loriere E, Bruel T, Schwartz O, van der Werf S, Jouvenet N, Nisole S, Vignuzzi M, Roesch F. Nat Commun. 2022 May 4;13(1):2442. doi: 10.1038/s41467-022-30134-9. PubMed |
| Nonlinear mechanics of human mitotic chromosomes. Meijering AEC, Sarlos K, Nielsen CF, Witt H, Harju J, Kerklingh E, Haasnoot GH, Bizard AH, Heller I, Broedersz CP, Liu Y, Peterman EJG, Hickson ID, Wuite GJL. Nature. 2022 May;605(7910):545-550. doi: 10.1038/s41586-022-04666-5. Epub 2022 May 4. PubMed |
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Multiplex base- and prime-editing with drive-and-process CRISPR arrays.
Yuan Q, Gao X.
Nat Commun. 2022 May 19;13(1):2771. doi: 10.1038/s41467-022-30514-1.
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| Loss of PTEN-Induced Kinase 1 Regulates Oncogenic Ras-Driven Tumor Growth By Inhibiting Mitochondrial Fission. Zhu D, Han F, Sun L, Agnihotri SK, Hu Y, Bueler H. Front Oncol. 2022 May 5;12:893396. doi: 10.3389/fonc.2022.893396. eCollection 2022. PubMed |
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| TP53-inducible putative long noncoding RNAs encode functional polypeptides that suppress cell proliferation. Xu W, Liu C, Deng B, Lin P, Sun Z, Liu A, Xuan J, Li Y, Zhou K, Zhang X, Huang Q, Zhou H, He Q, Li B, Qu L, Yang J. Genome Res. 2022 Jun;32(6):1026-1041. doi: 10.1101/gr.275831.121. Epub 2022 May 24. PubMed |
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| AURKA and PLK1 inhibition selectively and synergistically block cell cycle progression in diffuse midline glioma. Metselaar DS, du Chatinier A, Meel MH, Ter Huizen G, Waranecki P, Goulding JR, Bugiani M, Koster J, Kaspers GJL, Hulleman E. iScience. 2022 May 13;25(6):104398. doi: 10.1016/j.isci.2022.104398. eCollection 2022 Jun 17. PubMed |
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| Extracellular matrix regulates force transduction at VE-cadherin junctions. Kong X, Kapustka A, Sullivan B, Schwarz GJ, Leckband DE. Mol Biol Cell. 2022 Sep 15;33(11):ar95. doi: 10.1091/mbc.E22-03-0075. Epub 2022 Jun 2. PubMed |
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| Histone deacetylase 3 facilitates TNFalpha-mediated NF-kappaB activation through suppressing CTSB induced RIP1 degradation and is required for host defense against bacterial infection. Yang L, Chen S, Xia J, Zhou Y, Peng L, Fan H, Han Y, Duan L, Cheng G, Yang H, Xu F. Cell Biosci. 2022 Jun 3;12(1):81. doi: 10.1186/s13578-022-00814-6. PubMed |
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An in-library ligation strategy and its application in CRISPR/Cas9 screening of high-order gRNA combinations.
Lu Z, Ni K, Wang Y, Zhou Y, Li Y, Yan J, Song Q, Liu M, Xu Y, Yu Z, Guo T, Ma L.
Nucleic Acids Res. 2022 Jun 24;50(11):6575-6586. doi: 10.1093/nar/gkac458.
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| EZH2 endorses cell plasticity to non-small cell lung cancer cells facilitating mesenchymal to epithelial transition and tumour colonization. Gallardo A, Molina A, Asenjo HG, Lopez-Onieva L, Martorell-Marugan J, Espinosa-Martinez M, Grinan-Lison C, Alvarez-Perez JC, Cara FE, Navarro-Marchal SA, Carmona-Saez P, Medina PP, Marchal JA, Granados-Principal S, Sanchez-Pozo A, Landeira D. Oncogene. 2022 Jul;41(28):3611-3624. doi: 10.1038/s41388-022-02375-x. Epub 2022 Jun 9. PubMed |
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| Orgo-Seq integrates single-cell and bulk transcriptomic data to identify cell type specific-driver genes associated with autism spectrum disorder. Lim ET, Chan Y, Dawes P, Guo X, Erdin S, Tai DJC, Liu S, Reichert JM, Burns MJ, Chan YK, Chiang JJ, Meyer K, Zhang X, Walsh CA, Yankner BA, Raychaudhuri S, Hirschhorn JN, Gusella JF, Talkowski ME, Church GM. Nat Commun. 2022 Jun 10;13(1):3243. doi: 10.1038/s41467-022-30968-3. PubMed |
| Histone methyltransferase Dot1L recruits O-GlcNAc transferase to target chromatin sites to regulate histone O-GlcNAcylation. Xu B, Zhang C, Jiang A, Zhang X, Liang F, Wang X, Li D, Liu C, Liu X, Xia J, Li Y, Wang Y, Yang Z, Chen J, Zhou Y, Chen L, Sun H. J Biol Chem. 2022 Jul;298(7):102115. doi: 10.1016/j.jbc.2022.102115. Epub 2022 Jun 9. PubMed |
| Reciprocal regulation of NRF2 by autophagy and ubiquitin-proteasome modulates vascular endothelial injury induced by copper oxide nanoparticles. Li N, Du H, Mao L, Xu G, Zhang M, Fan Y, Dong X, Zheng L, Wang B, Qin X, Jiang X, Chen C, Zou Z, Zhang J. J Nanobiotechnology. 2022 Jun 11;20(1):270. doi: 10.1186/s12951-022-01486-7. PubMed |
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| Loss of YY1, a Regulator of Metabolism in Melanoma, Drives Melanoma Cell Invasiveness and Metastasis Formation. Guendisch U, Loos B, Cheng PF, Dummer R, Levesque MP, Varum S, Sommer L. Front Cell Dev Biol. 2022 May 26;10:916033. doi: 10.3389/fcell.2022.916033. eCollection 2022. PubMed |
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| Silver Nanoparticles Selectively Treat Neurofibromatosis Type 1-Associated Malignant Peripheral Nerve Sheath Tumors in a Neurofibromin-Dependent Manner. Alewine G, Knight J, Ghantae A, Mamrega C, Attiah B, Coover RA, Fahrenholtz CD. J Pers Med. 2022 Jun 30;12(7):1080. doi: 10.3390/jpm12071080. PubMed |
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| TRIM18 is a critical regulator of viral myocarditis and organ inflammation. Fang M, Zhang A, Du Y, Lu W, Wang J, Minze LJ, Cox TC, Li XC, Xing J, Zhang Z. J Biomed Sci. 2022 Jul 31;29(1):55. doi: 10.1186/s12929-022-00840-z. PubMed |
| Inhibition of acylglycerol kinase sensitizes DLBCL to venetoclax via upregulation of FOXO1-mediated BCL-2 expression. Ning N, Zhang S, Wu Q, Li X, Kuang D, Duan Y, Xia M, Liu H, Weng J, Ba H, Tang Z, Cheng X, Mei H, Huang L, Ao Q, Wang G, Hu Y, Laurence A, Wang J, Wang G, Yang XP. Theranostics. 2022 Jul 18;12(12):5537-5550. doi: 10.7150/thno.72786. eCollection 2022. PubMed |
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| FOXL2 and FOXA1 cooperatively assemble on the TP53 promoter in alternative dimer configurations. Choi Y, Luo Y, Lee S, Jin H, Yoon HJ, Hahn Y, Bae J, Lee HH. Nucleic Acids Res. 2022 Aug 26;50(15):8929-8946. doi: 10.1093/nar/gkac673. PubMed |
| A non-canonical vitamin K cycle is a potent ferroptosis suppressor. Mishima E, Ito J, Wu Z, Nakamura T, Wahida A, Doll S, Tonnus W, Nepachalovich P, Eggenhofer E, Aldrovandi M, Henkelmann B, Yamada KI, Wanninger J, Zilka O, Sato E, Feederle R, Hass D, Maida A, Mourao ASD, Linkermann A, Geissler EK, Nakagawa K, Abe T, Fedorova M, Proneth B, Pratt DA, Conrad M. Nature. 2022 Aug;608(7924):778-783. doi: 10.1038/s41586-022-05022-3. Epub 2022 Aug 3. PubMed |
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| Afadin couples RAS GTPases to the polarity rheostat Scribble. Goudreault M, Gagne V, Jo CH, Singh S, Killoran RC, Gingras AC, Smith MJ. Nat Commun. 2022 Aug 5;13(1):4562. doi: 10.1038/s41467-022-32335-8. PubMed |
| USP22 controls type III interferon signaling and SARS-CoV-2 infection through activation of STING. Karlowitz R, Stanifer ML, Roedig J, Andrieux G, Bojkova D, Bechtel M, Smith S, Kowald L, Schubert R, Boerries M, Cinatl J Jr, Boulant S, van Wijk SJL. Cell Death Dis. 2022 Aug 6;13(8):684. doi: 10.1038/s41419-022-05124-w. PubMed |
| Targeting interleukin 4 receptor alpha on tumor-associated macrophages reduces the pro-tumor macrophage phenotype. de Groot AE, Myers KV, Krueger TEG, Brennen WN, Amend SR, Pienta KJ. Neoplasia. 2022 Oct;32:100830. doi: 10.1016/j.neo.2022.100830. Epub 2022 Aug 5. PubMed |
| Acute lymphoblastic leukemia necessitates GSH-dependent ferroptosis defenses to overcome FSP1-epigenetic silencing. Pontel LB, Bueno-Costa A, Morellato AE, Carvalho Santos J, Roue G, Esteller M. Redox Biol. 2022 Jul 31;55:102408. doi: 10.1016/j.redox.2022.102408. PubMed |
| p38 MAPK-dependent phosphorylation of transcription factor SOX2 promotes an adaptive response to BRAF inhibitors in melanoma cells. Pietrobono S, De Paolo R, Mangiameli D, Marranci A, Battisti I, Franchin C, Arrigoni G, Melisi D, Poliseno L, Stecca B. J Biol Chem. 2022 Sep;298(9):102353. doi: 10.1016/j.jbc.2022.102353. Epub 2022 Aug 7. PubMed |
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| BNIP-2 Activation of Cellular Contractility Inactivates YAP for H9c2 Cardiomyoblast Differentiation. Wong DCP, Xiao J, Chew TW, Pan M, Lee CJM, Ang JW, Yow I, Thivakar T, Ackers-Johnson M, Lee NJW, Foo RS, Kanchanawong P, Low BC. Adv Sci (Weinh). 2022 Nov;9(31):e2202834. doi: 10.1002/advs.202202834. Epub 2022 Aug 17. PubMed |
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De novo pyrimidine synthesis is a targetable vulnerability in IDH mutant glioma.
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| RBM47 is a Critical Regulator of Mouse Embryonic Stem Cell Differentiation. Shivalingappa PKM, Singh DK, Sharma V, Arora V, Shiras A, Bapat SA. Stem Cell Rev Rep. 2023 Feb;19(2):475-490. doi: 10.1007/s12015-022-10441-w. Epub 2022 Aug 20. PubMed |
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| Regulation of membrane fluidity by RNF145-triggered degradation of the lipid hydrolase ADIPOR2. Volkmar N, Gawden-Bone CM, Williamson JC, Nixon-Abell J, West JA, St George-Hyslop PH, Kaser A, Lehner PJ. EMBO J. 2022 Oct 4;41(19):e110777. doi: 10.15252/embj.2022110777. Epub 2022 Aug 22. PubMed |
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| Human coronaviruses disassemble processing bodies. Kleer M, Mulloy RP, Robinson CA, Evseev D, Bui-Marinos MP, Castle EL, Banerjee A, Mubareka S, Mossman K, Corcoran JA. PLoS Pathog. 2022 Aug 23;18(8):e1010724. doi: 10.1371/journal.ppat.1010724. eCollection 2022 Aug. PubMed |
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| RASA2 ablation in T cells boosts antigen sensitivity and long-term function. Carnevale J, Shifrut E, Kale N, Nyberg WA, Blaeschke F, Chen YY, Li Z, Bapat SP, Diolaiti ME, O'Leary P, Vedova S, Belk J, Daniel B, Roth TL, Bachl S, Anido AA, Prinzing B, Ibanez-Vega J, Lange S, Haydar D, Luetke-Eversloh M, Born-Bony M, Hegde B, Kogan S, Feuchtinger T, Okada H, Satpathy AT, Shannon K, Gottschalk S, Eyquem J, Krenciute G, Ashworth A, Marson A. Nature. 2022 Sep;609(7925):174-182. doi: 10.1038/s41586-022-05126-w. Epub 2022 Aug 24. PubMed |
| Nanoscale segregation of channel and barrier claudins enables paracellular ion flux. Gonschior H, Schmied C, Van der Veen RE, Eichhorst J, Himmerkus N, Piontek J, Gunzel D, Bleich M, Furuse M, Haucke V, Lehmann M. Nat Commun. 2022 Aug 25;13(1):4985. doi: 10.1038/s41467-022-32533-4. PubMed |
| Ammonium tetrathiomolybdate triggers autophagy-dependent NRF2 activation in vascular endothelial cells. Zhang M, Qiu H, Mao L, Wang B, Li N, Fan Y, Weng P, Hu S, Dong X, Qin X, Chen C, Zou Z, Yu C, Zhang J. Cell Death Dis. 2022 Aug 25;13(8):733. doi: 10.1038/s41419-022-05183-z. PubMed |
| Generation of an Immortalized Human Adipose-Derived Mesenchymal Stromal Cell Line Suitable for Wound Healing Therapy. Iacomi DM, Rosca AM, Tutuianu R, Neagu TP, Pruna V, Simionescu M, Titorencu I. Int J Mol Sci. 2022 Aug 10;23(16):8925. doi: 10.3390/ijms23168925. PubMed |
| MicroRNA-223 Suppresses Human Hepatic Stellate Cell Activation Partly via Regulating the Actin Cytoskeleton and Alleviates Fibrosis in Organoid Models of Liver Injury. Ariyachet C, Chuaypen N, Kaewsapsak P, Chantaravisoot N, Jindatip D, Potikanond S, Tangkijvanich P. Int J Mol Sci. 2022 Aug 19;23(16):9380. doi: 10.3390/ijms23169380. PubMed |
| Decoding Functional High-Density Lipoprotein Particle Surfaceome Interactions. Frey K, Goetze S, Rohrer L, von Eckardstein A, Wollscheid B. Int J Mol Sci. 2022 Aug 22;23(16):9506. doi: 10.3390/ijms23169506. PubMed |
| scRNA-seq reveals ATPIF1 activity in control of T cell antitumor activity. Zhong G, Wang Q, Wang Y, Guo Y, Xu M, Guan Y, Zhang X, Wu M, Xu Z, Zhao W, Lian H, Wang H, Ye J. Oncoimmunology. 2022 Aug 20;11(1):2114740. doi: 10.1080/2162402X.2022.2114740. eCollection 2022. PubMed |
| S146L in MYC is a context-dependent activating substitution in cancer development. Hinds JW, Feris EJ, Wilkins OM, Deary LT, Wang X, Cole MD. PLoS One. 2022 Aug 26;17(8):e0272771. doi: 10.1371/journal.pone.0272771. eCollection 2022. PubMed |
| Exploring the mechanistic link between SF3B1 mutation and ring sideroblast formation in myelodysplastic syndrome. Ochi T, Fujiwara T, Ono K, Suzuki C, Nikaido M, Inoue D, Kato H, Onodera K, Ichikawa S, Fukuhara N, Onishi Y, Yokoyama H, Nakamura Y, Harigae H. Sci Rep. 2022 Aug 26;12(1):14562. doi: 10.1038/s41598-022-18921-2. PubMed |
| LncRNA MILIP links YBX1 to translational activation of Snai1 and promotes metastasis in clear cell renal cell carcinoma. Wang Y, Feng YC, Gan Y, Teng L, Wang L, La T, Wang P, Gu Y, Yan L, Li N, Zhang L, Wang L, Thorne RF, Zhang XD, Cao H, Shao FM. J Exp Clin Cancer Res. 2022 Aug 26;41(1):260. doi: 10.1186/s13046-022-02452-9. PubMed |
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| Trip13 Depletion in Liver Cancer Induces a Lipogenic Response Contributing to Plin2-Dependent Mitotic Cell Death. Rios Garcia M, Meissburger B, Chan J, de Guia RM, Mattijssen F, Roessler S, Birkenfeld AL, Raschzok N, Riols F, Tokarz J, Giroud M, Gil Lozano M, Hartleben G, Nawroth P, Haid M, Lopez M, Herzig S, Berriel Diaz M. Adv Sci (Weinh). 2022 Oct;9(29):e2104291. doi: 10.1002/advs.202104291. Epub 2022 Aug 28. PubMed |
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| Akkermansia muciniphila upregulates genes involved in maintaining the intestinal barrier function via ADP-heptose-dependent activation of the ALPK1/TIFA pathway. Martin-Gallausiaux C, Garcia-Weber D, Lashermes A, Larraufie P, Marinelli L, Teixeira V, Rolland A, Beguet-Crespel F, Brochard V, Quatremare T, Jamet A, Dore J, Gray-Owen SD, Blottiere HM, Arrieumerlou C, Lapaque N. Gut Microbes. 2022 Jan-Dec;14(1):2110639. doi: 10.1080/19490976.2022.2110639. PubMed |
| DJ-1 is an essential downstream mediator in PINK1/parkin-dependent mitophagy. Imberechts D, Kinnart I, Wauters F, Terbeek J, Manders L, Wierda K, Eggermont K, Madeiro RF, Sue C, Verfaillie C, Vandenberghe W. Brain. 2022 Dec 19;145(12):4368-4384. doi: 10.1093/brain/awac313. PubMed |
| Defining the HIV Capsid Binding Site of Nucleoporin 153. Li S, Patel JS, Yang J, Crabtree AM, Rubenstein BM, Lund-Andersen PK, Ytreberg FM, Rowley PA. mSphere. 2022 Oct 26;7(5):e0031022. doi: 10.1128/msphere.00310-22. Epub 2022 Aug 30. PubMed |
| SMNDC1 links chromatin remodeling and splicing to regulate pancreatic hormone expression. Casteels T, Bajew S, Reinis J, Enders L, Schuster M, Fontaine F, Muller AC, Wagner BK, Bock C, Kubicek S. Cell Rep. 2022 Aug 30;40(9):111288. doi: 10.1016/j.celrep.2022.111288. PubMed |
| DEPDC5-dependent mTORC1 signaling mechanisms are critical for the anti-seizure effects of acute fasting. Yuskaitis CJ, Modasia JB, Schrotter S, Rossitto LA, Groff KJ, Morici C, Mithal DS, Chakrabarty RP, Chandel NS, Manning BD, Sahin M. Cell Rep. 2022 Aug 30;40(9):111278. doi: 10.1016/j.celrep.2022.111278. PubMed |
Production of human entorhinal stellate cell-like cells by forward programming shows an important role of Foxp1 in reprogramming.
Bergmann T, Liu Y, Skov J, Mogus L, Lee J, Pfisterer U, Handfield LF, Asenjo-Martinez A, Lisa-Vargas I, Seemann SE, Lee JTH, Patikas N, Kornum BR, Denham M, Hyttel P, Witter MP, Gorodkin J, Pers TH, Hemberg M, Khodosevich K, Hall VJ.
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| The histone methyltransferase SETD2 negatively regulates cell size. Molenaar TM, Malik M, Silva J, Liu NQ, Haarhuis JHI, Ambrosi C, Kwesi-Maliepaard EM, van Welsem T, Baubec T, Faller WJ, van Leeuwen F. J Cell Sci. 2022 Oct 1;135(19):jcs259856. doi: 10.1242/jcs.259856. Epub 2022 Oct 6. PubMed |
| Piezo1 stimulates mitochondrial function via cAMP signaling. Li X, Kordsmeier J, Nookaew I, Kim HN, Xiong J. FASEB J. 2022 Oct;36(10):e22519. doi: 10.1096/fj.202200300R. PubMed |
| Protein import motor complex reacts to mitochondrial misfolding by reducing protein import and activating mitophagy. Michaelis JB, Brunstein ME, Bozkurt S, Alves L, Wegner M, Kaulich M, Pohl C, Munch C. Nat Commun. 2022 Sep 2;13(1):5164. doi: 10.1038/s41467-022-32564-x. PubMed |
| Induced hepatic stem cells maintain self-renewal through the high expression of Myc coregulated by TET1 and CTCF. Wang C, Yu X, Ding S, Liu Y, Zhang H, Fu J, Yu B, Zhu H. Cell Biosci. 2022 Sep 2;12(1):143. doi: 10.1186/s13578-022-00883-7. PubMed |
| Redox regulation of RAD51 Cys319 and homologous recombination by peroxiredoxin 1. Skoko JJ, Cao J, Gaboriau D, Attar M, Asan A, Hong L, Paulsen CE, Ma H, Liu Y, Wu H, Harkness T, Furdui CM, Manevich Y, Morrison CG, Brown ET, Normolle D, Spies M, Spies MA, Carroll K, Neumann CA. Redox Biol. 2022 Oct;56:102443. doi: 10.1016/j.redox.2022.102443. Epub 2022 Aug 24. PubMed |
Generation of dual-gRNA library for combinatorial CRISPR screening of synthetic lethal gene pairs.
Tang S, Wu X, Liu J, Zhang Q, Wang X, Shao S, Gokbag B, Fan K, Liu X, Li F, Cheng L, Li L.
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| Massively parallel genomic perturbations with multi-target CRISPR interrogates Cas9 activity and DNA repair at endogenous sites. Zou RS, Marin-Gonzalez A, Liu Y, Liu HB, Shen L, Dveirin RK, Luo JXJ, Kalhor R, Ha T. Nat Cell Biol. 2022 Sep;24(9):1433-1444. doi: 10.1038/s41556-022-00975-z. Epub 2022 Sep 5. PubMed |
| Indisulam synergizes with palbociclib to induce senescence through inhibition of CDK2 kinase activity. Pogacar Z, Johnson JL, Krenning L, De Conti G, Jochems F, Lieftink C, Velds A, Wardak L, Groot K, Schepers A, Wang L, Song JY, van de Ven M, van Tellingen O, Medema RH, Beijersbergen RL, Bernards R, Leite de Oliveira R. PLoS One. 2022 Sep 6;17(9):e0273182. doi: 10.1371/journal.pone.0273182. eCollection 2022. PubMed |
| Multimodal single cell sequencing implicates chromatin accessibility and genetic background in diabetic kidney disease progression. Wilson PC, Muto Y, Wu H, Karihaloo A, Waikar SS, Humphreys BD. Nat Commun. 2022 Sep 6;13(1):5253. doi: 10.1038/s41467-022-32972-z. PubMed |
| Oncohistone interactome profiling uncovers contrasting oncogenic mechanisms and identifies potential therapeutic targets in high grade glioma. Siddaway R, Canty L, Pajovic S, Milos S, Coyaud E, Sbergio SG, Vadivel Anguraj AK, Lubanszky E, Yun HY, Portante A, Carette S, Zhang C, Moran MF, Raught B, Campos EI, Hawkins C. Acta Neuropathol. 2022 Nov;144(5):1027-1048. doi: 10.1007/s00401-022-02489-2. Epub 2022 Sep 7. PubMed |
| Runx2 regulates chromatin accessibility to direct the osteoblast program at neonatal stages. Hojo H, Saito T, He X, Guo Q, Onodera S, Azuma T, Koebis M, Nakao K, Aiba A, Seki M, Suzuki Y, Okada H, Tanaka S, Chung UI, McMahon AP, Ohba S. Cell Rep. 2022 Sep 6;40(10):111315. doi: 10.1016/j.celrep.2022.111315. PubMed |
| Genetic determinants of chromatin reveal prostate cancer risk mediated by context-dependent gene regulation. Baca SC, Singler C, Zacharia S, Seo JH, Morova T, Hach F, Ding Y, Schwarz T, Huang CF, Anderson J, Fay AP, Kalita C, Groha S, Pomerantz MM, Wang V, Linder S, Sweeney CJ, Zwart W, Lack NA, Pasaniuc B, Takeda DY, Gusev A, Freedman ML. Nat Genet. 2022 Sep;54(9):1364-1375. doi: 10.1038/s41588-022-01168-y. Epub 2022 Sep 7. PubMed |
| Regulation of mitophagy by the NSL complex underlies genetic risk for Parkinson's disease at 16q11.2 and MAPT H1 loci. Soutar MPM, Melandri D, O'Callaghan B, Annuario E, Monaghan AE, Welsh NJ, D'Sa K, Guelfi S, Zhang D, Pittman A, Trabzuni D, Verboven AHA, Pan KS, Kia DA, Bictash M, Gandhi S, Houlden H, Cookson MR, Kasri NN, Wood NW, Singleton AB, Hardy J, Whiting PJ, Blauwendraat C, Whitworth AJ, Manzoni C, Ryten M, Lewis PA, Plun-Favreau H. Brain. 2022 Dec 19;145(12):4349-4367. doi: 10.1093/brain/awac325. PubMed |
| YAP and TAZ play a crucial role in human erythrocyte maturation and enucleation. Damkham N, Lorthongpanich C, Klaihmon P, Lueangamornnara U, Kheolamai P, Trakarnsanga K, Issaragrisil S. Stem Cell Res Ther. 2022 Sep 8;13(1):467. doi: 10.1186/s13287-022-03166-7. PubMed |
| Interplay between the Chd4/NuRD Complex and the Transcription Factor Znf219 Controls Cardiac Cell Identity. El Abdellaoui-Soussi F, Yunes-Leites PS, Lopez-Maderuelo D, Garcia-Marques F, Vazquez J, Redondo JM, Gomez-Del Arco P. Int J Mol Sci. 2022 Aug 24;23(17):9565. doi: 10.3390/ijms23179565. PubMed |
| Modeling Colorectal Cancer Progression Reveals Niche-Dependent Clonal Selection. Vaquero-Siguero N, Schleussner N, Volk J, Mastel M, Meier J, Jackstadt R. Cancers (Basel). 2022 Aug 31;14(17):4260. doi: 10.3390/cancers14174260. PubMed |
| Live-cell imaging in human colonic monolayers reveals ERK waves limit the stem cell compartment to maintain epithelial homeostasis. Pond KW, Morris JM, Alkhimenok O, Varghese RP, Cabel CR, Ellis NA, Chakrabarti J, Zavros Y, Merchant JL, Thorne CA, Paek AL. Elife. 2022 Sep 12;11:e78837. doi: 10.7554/eLife.78837. PubMed |
| GCAF(TMEM251) regulates lysosome biogenesis by activating the mannose-6-phosphate pathway. Zhang W, Yang X, Li Y, Yu L, Zhang B, Zhang J, Cho WJ, Venkatarangan V, Chen L, Burugula BB, Bui S, Wang Y, Duan C, Kitzman JO, Li M. Nat Commun. 2022 Sep 12;13(1):5351. doi: 10.1038/s41467-022-33025-1. PubMed |
| Smc5/6 silences episomal transcription by a three-step function. Abdul F, Diman A, Baechler B, Ramakrishnan D, Kornyeyev D, Beran RK, Fletcher SP, Strubin M. Nat Struct Mol Biol. 2022 Sep;29(9):922-931. doi: 10.1038/s41594-022-00829-0. Epub 2022 Sep 12. PubMed |
| Targeting histone methylation to reprogram the transcriptional state that drives survival of drug-tolerant myeloid leukemia persisters. van Gils N, Verhagen HJMP, Broux M, Martianez T, Denkers F, Vermue E, Rutten A, Csikos T, Demeyer S, Cil M, Al M, Cools J, Janssen JJWM, Ossenkoppele GJ, Menezes RX, Smit L. iScience. 2022 Aug 25;25(9):105013. doi: 10.1016/j.isci.2022.105013. eCollection 2022 Sep 16. PubMed |
| Cisplatin and gemcitabine exert opposite effects on immunotherapy with PD-1 antibody in K-ras-driven cancer. Glorieux C, Xia X, You X, Wang Z, Han Y, Yang J, Noppe G, Meester C, Ling J, Robert A, Zhang H, Li SP, Wang H, Chiao PJ, Zhang L, Li X, Huang P. J Adv Res. 2022 Sep;40:109-124. doi: 10.1016/j.jare.2021.12.005. Epub 2021 Dec 21. PubMed |
| Pathogenic variants of sphingomyelin synthase SMS2 disrupt lipid landscapes in the secretory pathway. Sokoya T, Parolek J, Foged MM, Danylchuk DI, Bozan M, Sarkar B, Hilderink A, Philippi M, Botto LD, Terhal PA, Makitie O, Piehler J, Kim Y, Burd CG, Klymchenko AS, Maeda K, Holthuis JCM. Elife. 2022 Sep 14;11:e79278. doi: 10.7554/eLife.79278. PubMed |
| SerpinB3 drives cancer stem cell survival in glioblastoma. Lauko A, Volovetz J, Turaga SM, Bayik D, Silver DJ, Mitchell K, Mulkearns-Hubert EE, Watson DC, Desai K, Midha M, Hao J, McCortney K, Steffens A, Naik U, Ahluwalia MS, Bao S, Horbinski C, Yu JS, Lathia JD. Cell Rep. 2022 Sep 13;40(11):111348. doi: 10.1016/j.celrep.2022.111348. PubMed |
| Ceramide nanoliposomes augment the efficacy of venetoclax and cytarabine in models of acute myeloid leukemia. Khokhlatchev AV, Sharma A, Deering TG, Shaw JJP, Costa-Pinheiro P, Golla U, Annageldiyev C, Cabot MC, Conaway MR, Tan SF, Ung J, Feith DJ, Loughran TP Jr, Claxton DF, Fox TE, Kester M. FASEB J. 2022 Oct;36(10):e22514. doi: 10.1096/fj.202200765R. PubMed |
| Double-strand break toxicity is chromatin context independent. Friskes A, Koob L, Krenning L, Severson TM, Koeleman ES, Vergara X, Schubert M, van den Berg J, Evers B, Manjon AG, Joosten S, Kim Y, Zwart W, Medema RH. Nucleic Acids Res. 2022 Sep 23;50(17):9930-9947. doi: 10.1093/nar/gkac758. PubMed |
| Biphasic regulation of CFTR expression by ENaC in epithelial cells: The involvement of Ca(2+)-modulated cAMP production. Wuchu F, Ma X, Que Y, Chen J, Ruan YC. Front Cell Dev Biol. 2022 Aug 30;10:781762. doi: 10.3389/fcell.2022.781762. eCollection 2022. PubMed |
| Cancer cell autophagy, reprogrammed macrophages, and remodeled vasculature in glioblastoma triggers tumor immunity. Chryplewicz A, Scotton J, Tichet M, Zomer A, Shchors K, Joyce JA, Homicsko K, Hanahan D. Cancer Cell. 2022 Oct 10;40(10):1111-1127.e9. doi: 10.1016/j.ccell.2022.08.014. Epub 2022 Sep 15. PubMed |
Gain-of-function genetic screens in human cells identify SLC transporters overcoming environmental nutrient restrictions.
Rebsamen M, Girardi E, Sedlyarov V, Scorzoni S, Papakostas K, Vollert M, Konecka J, Guertl B, Klavins K, Wiedmer T, Superti-Furga G.
Life Sci Alliance. 2022 Sep 16;5(11):e202201404. doi: 10.26508/lsa.202201404. Print 2022 Nov.
PubMed
Associated Plasmids |
| CRISPR-Cas9 screen in human embryonic stem cells to identify genes required for neural differentiation. Qi S, Sivakumar S, Yu H. STAR Protoc. 2022 Dec 16;3(4):101682. doi: 10.1016/j.xpro.2022.101682. Epub 2022 Sep 16. PubMed |
1-deoxysphingolipid synthesis compromises anchorage-independent growth and plasma membrane endocytosis in cancer cells.
Cordes T, Kuna RS, McGregor GH, Khare SV, Gengatharan J, Muthusamy T, Metallo CM.
J Lipid Res. 2022 Sep 14:100281. doi: 10.1016/j.jlr.2022.100281.
PubMed
Associated Plasmids |
| Oncogenic RAS commandeers amino acid sensing machinery to aberrantly activate mTORC1 in multiple myeloma. Yang Y, Bolomsky A, Oellerich T, Chen P, Ceribelli M, Haupl B, Wright GW, Phelan JD, Huang DW, Lord JW, Van Winkle CK, Yu X, Wisniewski J, Wang JQ, Tosto FA, Beck E, Wilson K, McKnight C, Travers J, Klumpp-Thomas C, Smith GA, Pittaluga S, Maric I, Kazandjian D, Thomas CJ, Young RM. Nat Commun. 2022 Sep 17;13(1):5469. doi: 10.1038/s41467-022-33142-x. PubMed |
| Reversal of IKZF1-induced glucocorticoid resistance by dual targeting of AKT and ERK signaling pathways. Butler M, Vervoort BMT, van Ingen Schenau DS, Jongeneel L, van der Zwet JCG, Marke R, Meijerink JPP, Scheijen B, van der Meer LT, van Leeuwen FN. Front Oncol. 2022 Sep 2;12:905665. doi: 10.3389/fonc.2022.905665. eCollection 2022. PubMed |
| SOX9 maintains human foetal lung tip progenitor state by enhancing WNT and RTK signalling. Sun D, Llora Batlle O, van den Ameele J, Thomas JC, He P, Lim K, Tang W, Xu C, Meyer KB, Teichmann SA, Marioni JC, Jackson SP, Brand AH, Rawlins EL. EMBO J. 2022 Nov 2;41(21):e111338. doi: 10.15252/embj.2022111338. Epub 2022 Sep 19. PubMed |
| Thiopurines inhibit coronavirus Spike protein processing and incorporation into progeny virions. Pringle ES, Duguay BA, Bui-Marinos MP, Mulloy RP, Landreth SL, Desireddy KS, Dolliver SM, Ying S, Caddell T, Tooley TH, Slaine PD, Bearne SL, Falzarano D, Corcoran JA, Khaperskyy DA, McCormick C. PLoS Pathog. 2022 Sep 19;18(9):e1010832. doi: 10.1371/journal.ppat.1010832. eCollection 2022 Sep. PubMed |
| Autophagy-linked plasma and lysosomal membrane protein PLAC8 is a key host factor for SARS-CoV-2 entry into human cells. Ugalde AP, Bretones G, Rodriguez D, Quesada V, Llorente F, Fernandez-Delgado R, Jimenez-Clavero MA, Vazquez J, Calvo E, Tamargo-Gomez I, Marino G, Roiz-Valle D, Maeso D, Araujo-Voces M, Espanol Y, Barcelo C, Freije JM, Lopez-Soto A, Lopez-Otin C. EMBO J. 2022 Nov 2;41(21):e110727. doi: 10.15252/embj.2022110727. Epub 2022 Oct 4. PubMed |
| GABP couples oncogene signaling to telomere regulation in TERT promoter mutant cancer. McKinney AM, Mathur R, Stevers NO, Molinaro AM, Chang SM, Phillips JJ, Costello JF. Cell Rep. 2022 Sep 20;40(12):111344. doi: 10.1016/j.celrep.2022.111344. PubMed |
| Snail maintains the stem/progenitor state of skin epithelial cells and carcinomas through the autocrine effect of matricellular protein Mindin. Badarinath K, Dam B, Kataria S, Zirmire RK, Dey R, Kansagara G, Ajnabi J, Hegde A, Singh R, Masudi T, Sambath J, Sachithanandan SP, Kumar P, Gulyani A, He YW, Krishna S, Jamora C. Cell Rep. 2022 Sep 20;40(12):111390. doi: 10.1016/j.celrep.2022.111390. PubMed |
| METTL16 antagonizes MRE11-mediated DNA end resection and confers synthetic lethality to PARP inhibition in pancreatic ductal adenocarcinoma. Zeng X, Zhao F, Cui G, Zhang Y, Deshpande RA, Chen Y, Deng M, Kloeber JA, Shi Y, Zhou Q, Zhang C, Hou J, Kim W, Tu X, Yan Y, Xu Z, Chen L, Gao H, Guo G, Liu J, Zhu Q, Cao Y, Huang J, Wu Z, Zhu S, Yin P, Luo K, Mer G, Paull TT, Yuan J, Tao K, Lou Z. Nat Cancer. 2022 Sep;3(9):1088-1104. doi: 10.1038/s43018-022-00429-3. Epub 2022 Sep 22. PubMed |
| Memory CD8(+) T cell diversity and B cell responses correlate with protection against SARS-CoV-2 following mRNA vaccination. Brasu N, Elia I, Russo V, Montacchiesi G, Stabile SA, De Intinis C, Fesi F, Gizzi K, Macagno M, Montone M, Mussolin B, Grifoni A, Faravelli S, Marchese S, Forneris F, De Francesco R, Sette A, Barnaba V, Sottile A, Sapino A, Pace L. Nat Immunol. 2022 Oct;23(10):1445-1456. doi: 10.1038/s41590-022-01313-z. Epub 2022 Sep 22. PubMed |
| RBM15 condensates modulate m(6)A modification of STYK1 to promote tumorigenesis. Jiang A, Zhang S, Wang X, Li D. Comput Struct Biotechnol J. 2022 Sep 5;20:4825-4836. doi: 10.1016/j.csbj.2022.08.068. eCollection 2022. PubMed |
| A screening-compatible live cell fluorescence resonance energy transfer-based assay for modulation of Rho GTPase activity. Muller PM, Rocks O. STAR Protoc. 2022 Dec 16;3(4):101705. doi: 10.1016/j.xpro.2022.101705. Epub 2022 Sep 22. PubMed |
| Regulatory chromatin rewiring promotes metabolic switching during adaptation to oncogenic receptor tyrosine kinase inhibition. Ogden S, Carys K, Ahmed I, Bruce J, Sharrocks AD. Oncogene. 2022 Oct;41(43):4808-4822. doi: 10.1038/s41388-022-02465-w. Epub 2022 Sep 24. PubMed |
| Inhibition of HIV-1 replication using the CRISPR/cas9-no NLS system as a prophylactic strategy. Salimi-Jeda A, Esghaei M, Hossein Keyvani, Bokharaei-Salim F, Teimoori A, Abdoli A. Heliyon. 2022 Aug 31;8(9):e10483. doi: 10.1016/j.heliyon.2022.e10483. eCollection 2022 Sep. PubMed |
| A novel oncogenic enhancer of estrogen receptor-positive breast cancer. Bao C, Duan J, Xie Y, Liu Y, Li P, Li J, Zhao H, Guo H, Men Y, Ren Y, Xu J, Wang G, Lu W. Mol Ther Nucleic Acids. 2022 Aug 24;29:836-851. doi: 10.1016/j.omtn.2022.08.029. eCollection 2022 Sep 13. PubMed |
Quantification of Genome Editing and Transcriptional Control Capabilities Reveals Hierarchies among Diverse CRISPR/Cas Systems in Human Cells.
Escobar M, Li J, Patel A, Liu S, Xu Q, Hilton IB.
ACS Synth Biol. 2022 Oct 21;11(10):3239-3250. doi: 10.1021/acssynbio.2c00156. Epub 2022 Sep 26.
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Associated Plasmids |
| Altered-Self MHC Class I Sensing via Functionally Disparate Paired NK Cell Receptors Counters Murine Cytomegalovirus gp34-Mediated Immune Evasion. Cronk JM, Dziewulska KH, Puchalski P, Crittenden RB, Hammarskjold ML, Brown MG. J Immunol. 2022 Oct 15;209(8):1545-1554. doi: 10.4049/jimmunol.2200441. Epub 2022 Sep 7. PubMed |
| Resurrecting essential amino acid biosynthesis in mammalian cells. Trolle J, McBee RM, Kaufman A, Pinglay S, Berger H, German S, Liu L, Shen MJ, Guo X, Martin JA, Pacold ME, Jones DR, Boeke JD, Wang HH. Elife. 2022 Sep 27;11:e72847. doi: 10.7554/eLife.72847. PubMed |
Translational enhancement by base editing of the Kozak sequence rescues haploinsufficiency.
Ambrosini C, Destefanis E, Kheir E, Broso F, Alessandrini F, Longhi S, Battisti N, Pesce I, Dassi E, Petris G, Cereseto A, Quattrone A.
Nucleic Acids Res. 2022 Oct 14;50(18):10756-10771. doi: 10.1093/nar/gkac799.
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Associated Plasmids |
| Generation of a recombinant version of a biologically active cell-permeant human HAND2 transcription factor from E. coli. Haridhasapavalan KK, Sundaravadivelu PK, Joshi N, Das NJ, Mohapatra A, Voorkara U, Kaveeshwar V, Thummer RP. Sci Rep. 2022 Sep 27;12(1):16129. doi: 10.1038/s41598-022-19745-w. PubMed |
| BRD4 PROTAC degrader MZ1 exerts anticancer effects in acute myeloid leukemia by targeting c-Myc and ANP32B genes. Ma L, Wang J, Zhang Y, Fang F, Ling J, Chu X, Zhang Z, Tao Y, Li X, Tian Y, Li Z, Sang X, Zhang K, Lu L, Wan X, Chen Y, Yu J, Zhuo R, Wu S, Lu J, Pan J, Hu S. Cancer Biol Ther. 2022 Dec 31;23(1):1-15. doi: 10.1080/15384047.2022.2125748. PubMed |
| Dengue activates mTORC2 signaling to counteract apoptosis and maximize viral replication. Carter CC, Mast FD, Olivier JP, Bourgeois NM, Kaushansky A, Aitchison JD. Front Cell Infect Microbiol. 2022 Sep 12;12:979996. doi: 10.3389/fcimb.2022.979996. eCollection 2022. PubMed |
| A cancer stem cell associated gene signature for predicting overall survival of hepatocellular carcinoma. Liang XY, Zhang Y, He YN, Liu XY, Ding ZH, Zhang XD, Dong MY, Du RL. Front Genet. 2022 Sep 12;13:888601. doi: 10.3389/fgene.2022.888601. eCollection 2022. PubMed |
| Host specific sensing of coronaviruses and picornaviruses by the CARD8 inflammasome. Tsu BV, Agarwal R, Gokhale NS, Kulsuptrakul J, Ryan AP, Castro LK, Beierschmitt CM, Turcotte EA, Fay EJ, Vance RE, Hyde JL, Savan R, Mitchell PS, Daugherty MD. bioRxiv. 2022 Sep 22:2022.09.21.508960. doi: 10.1101/2022.09.21.508960. Preprint. PubMed |
| Aging-regulated TUG1 is dispensable for endothelial cell function. Gimbel AT, Koziarek S, Theodorou K, Schulz JF, Stanicek L, Kremer V, Ali T, Gunther S, Kumar S, Jo H, Hubner N, Maegdefessel L, Dimmeler S, van Heesch S, Boon RA. PLoS One. 2022 Sep 29;17(9):e0265160. doi: 10.1371/journal.pone.0265160. eCollection 2022. PubMed |
| Cell clusters adopt a collective amoeboid mode of migration in confined nonadhesive environments. Pages DL, Dornier E, de Seze J, Gontran E, Maitra A, Maciejewski A, Wang L, Luan R, Cartry J, Canet-Jourdan C, Raingeaud J, Lemahieu G, Lebel M, Ducreux M, Gelli M, Scoazec JY, Coppey M, Voituriez R, Piel M, Jaulin F. Sci Adv. 2022 Sep 30;8(39):eabp8416. doi: 10.1126/sciadv.abp8416. Epub 2022 Sep 30. PubMed |
| Human immunoglobulin repertoire analysis guides design of vaccine priming immunogens targeting HIV V2-apex broadly neutralizing antibody precursors. Willis JR, Berndsen ZT, Ma KM, Steichen JM, Schiffner T, Landais E, Liguori A, Kalyuzhniy O, Allen JD, Baboo S, Omorodion O, Diedrich JK, Hu X, Georgeson E, Phelps N, Eskandarzadeh S, Groschel B, Kubitz M, Adachi Y, Mullin TM, Alavi NB, Falcone S, Himansu S, Carfi A, Wilson IA, Yates JR 3rd, Paulson JC, Crispin M, Ward AB, Schief WR. Immunity. 2022 Nov 8;55(11):2149-2167.e9. doi: 10.1016/j.immuni.2022.09.001. Epub 2022 Sep 29. PubMed |
| Induced retinal pigment epithelial cells with anti-epithelial-to-mesenchymal transition ability delay retinal degeneration. Tian H, Chen Z, Zhu X, Ou Q, Wang Z, Wu B, Xu JY, Jin C, Gao F, Wang J, Zhang J, Zhang J, Lu L, Xu GT. iScience. 2022 Sep 2;25(10):105050. doi: 10.1016/j.isci.2022.105050. eCollection 2022 Oct 21. PubMed |
| Cisplatin-induced HSF1-HSP90 axis enhances the expression of functional PD-L1 in oral squamous cell carcinoma. Sasaya T, Kubo T, Murata K, Mizue Y, Sasaki K, Yanagawa J, Imagawa M, Kato H, Tsukahara T, Kanaseki T, Tamura Y, Miyazaki A, Hirohashi Y, Torigoe T. Cancer Med. 2023 Feb;12(4):4605-4615. doi: 10.1002/cam4.5310. Epub 2022 Oct 6. PubMed |
| Vitamin C epigenetically controls osteogenesis and bone mineralization. Thaler R, Khani F, Sturmlechner I, Dehghani SS, Denbeigh JM, Zhou X, Pichurin O, Dudakovic A, Jerez SS, Zhong J, Lee JH, Natarajan R, Kalajzic I, Jiang YH, Deyle DR, Paschalis EP, Misof BM, Ordog T, van Wijnen AJ. Nat Commun. 2022 Oct 6;13(1):5883. doi: 10.1038/s41467-022-32915-8. PubMed |
| Lineage-coupled clonal capture identifies clonal evolution mechanisms and vulnerabilities of BRAF(V600E) inhibition resistance in melanoma. Zhang ZY, Ding Y, Ezhilarasan R, Lhakhang T, Wang Q, Yang J, Modrek AS, Zhang H, Tsirigos A, Futreal A, Draetta GF, Verhaak RGW, Sulman EP. Cell Discov. 2022 Oct 6;8(1):102. doi: 10.1038/s41421-022-00462-7. PubMed |
Spatiotemporal dynamics of membrane surface charge regulates cell polarity and migration.
Banerjee T, Biswas D, Pal DS, Miao Y, Iglesias PA, Devreotes PN.
Nat Cell Biol. 2022 Oct;24(10):1499-1515. doi: 10.1038/s41556-022-00997-7. Epub 2022 Oct 6.
PubMed
Associated Plasmids |
| Deficiency of the frontotemporal dementia gene GRN results in gangliosidosis. Boland S, Swarup S, Ambaw YA, Malia PC, Richards RC, Fischer AW, Singh S, Aggarwal G, Spina S, Nana AL, Grinberg LT, Seeley WW, Surma MA, Klose C, Paulo JA, Nguyen AD, Harper JW, Walther TC, Farese RV Jr. Nat Commun. 2022 Oct 7;13(1):5924. doi: 10.1038/s41467-022-33500-9. PubMed |
| CAMSAP2 promotes colorectal cancer cell migration and invasion through activation of JNK/c-Jun/MMP-1 signaling pathway. Wang X, Liu Y, Ding Y, Feng G. Sci Rep. 2022 Oct 7;12(1):16899. doi: 10.1038/s41598-022-21345-7. PubMed |
| Controllable DNA hybridization by host-guest complexation-mediated ligand invasion. Xiao L, Wang LL, Wu CQ, Li H, Zhang QL, Wang Y, Xu L. Nat Commun. 2022 Oct 8;13(1):5936. doi: 10.1038/s41467-022-33738-3. PubMed |
| A genome-wide screen identifies SCAI as a modulator of the UV-induced replicative stress response. Lemay JF, St-Hilaire E, Ronato DA, Gao Y, Belanger F, Gezzar-Dandashi S, Kimenyi Ishimwe AB, Sawchyn C, Levesque D, McQuaid M, Boisvert FM, Mallette FA, Masson JY, Drobetsky EA, Wurtele H. PLoS Biol. 2022 Oct 10;20(10):e3001543. doi: 10.1371/journal.pbio.3001543. eCollection 2022 Oct. PubMed |
| Tetraspanin-5-mediated MHC class I clustering is required for optimal CD8 T cell activation. Colbert JD, Cruz FM, Baer CE, Rock KL. Proc Natl Acad Sci U S A. 2022 Oct 18;119(42):e2122188119. doi: 10.1073/pnas.2122188119. Epub 2022 Oct 10. PubMed |
| Rapid Generation of Circulating and Mucosal Decoy Human ACE2 using mRNA Nanotherapeutics for the Potential Treatment of SARS-CoV-2. Kim J, Jozic A, Mukherjee A, Nelson D, Chiem K, Khan MSR, Torrelles JB, Martinez-Sobrido L, Sahay G. Adv Sci (Weinh). 2022 Dec;9(35):e2202556. doi: 10.1002/advs.202202556. Epub 2022 Oct 10. PubMed |
Systematic discovery of recombinases for efficient integration of large DNA sequences into the human genome.
Durrant MG, Fanton A, Tycko J, Hinks M, Chandrasekaran SS, Perry NT, Schaepe J, Du PP, Lotfy P, Bassik MC, Bintu L, Bhatt AS, Hsu PD.
Nat Biotechnol. 2022 Oct 10. pii: 10.1038/s41587-022-01494-w. doi: 10.1038/s41587-022-01494-w.
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Associated Plasmids |
| The coilin N-terminus mediates multivalent interactions between coilin and Nopp140 to form and maintain Cajal bodies. Courchaine E, Gelles-Watnick S, Machyna M, Straube K, Sauyet S, Enright J, Neugebauer KM. Nat Commun. 2022 Oct 12;13(1):6005. doi: 10.1038/s41467-022-33434-2. PubMed |
| LRRC15 inhibits SARS-CoV-2 cellular entry in trans. Song J, Chow RD, Pena-Hernandez MA, Zhang L, Loeb SA, So EY, Liang OD, Ren P, Chen S, Wilen CB, Lee S. PLoS Biol. 2022 Oct 13;20(10):e3001805. doi: 10.1371/journal.pbio.3001805. eCollection 2022 Oct. PubMed |
| Combining NGN2 programming and dopaminergic patterning for a rapid and efficient generation of hiPSC-derived midbrain neurons. Sheta R, Teixeira M, Idi W, Pierre M, de Rus Jacquet A, Emond V, Zorca CE, Vanderperre B, Durcan TM, Fon EA, Calon F, Chahine M, Oueslati A. Sci Rep. 2022 Oct 13;12(1):17176. doi: 10.1038/s41598-022-22158-4. PubMed |
| Early Mechanisms of Chemoresistance in Retinoblastoma. Zhang MG, Kuznetsoff JN, Owens DA, Gallo RA, Kalahasty K, Cruz AM, Kurtenbach S, Correa ZM, Pelaez D, Harbour JW. Cancers (Basel). 2022 Oct 10;14(19):4966. doi: 10.3390/cancers14194966. PubMed |
| A novel protein RASON encoded by a lncRNA controls oncogenic RAS signaling in KRAS mutant cancers. Cheng R, Li F, Zhang M, Xia X, Wu J, Gao X, Zhou H, Zhang Z, Huang N, Yang X, Zhang Y, Shen S, Kang T, Liu Z, Xiao F, Yao H, Xu J, Yan C, Zhang N. Cell Res. 2023 Jan;33(1):30-45. doi: 10.1038/s41422-022-00726-7. Epub 2022 Oct 14. PubMed |
| HERC2 deficiency activates C-RAF/MKK3/p38 signalling pathway altering the cellular response to oxidative stress. Sala-Gaston J, Pedrazza L, Ramirez J, Martinez-Martinez A, Rawlins LE, Baple EL, Crosby AH, Mayor U, Ventura F, Rosa JL. Cell Mol Life Sci. 2022 Oct 14;79(11):548. doi: 10.1007/s00018-022-04586-7. PubMed |
| ATF4-dependent fructolysis fuels growth of glioblastoma multiforme. Chen C, Zhang Z, Liu C, Wang B, Liu P, Fang S, Yang F, You Y, Li X. Nat Commun. 2022 Oct 16;13(1):6108. doi: 10.1038/s41467-022-33859-9. PubMed |
| MYC-mediated silencing of miR-181a-5p promotes pathogenic Th17 responses by modulating AKT3-FOXO3 signaling. Chen S, Ma B, Li X, Zhang K, Wei Y, Du B, Liu X, Wei R, Li X, Nian H. iScience. 2022 Sep 23;25(10):105176. doi: 10.1016/j.isci.2022.105176. eCollection 2022 Oct 21. PubMed |
| Polarized NHE1 and SWELL1 regulate migration direction, efficiency and metastasis. Zhang Y, Li Y, Thompson KN, Stoletov K, Yuan Q, Bera K, Lee SJ, Zhao R, Kiepas A, Wang Y, Mistriotis P, Serra SA, Lewis JD, Valverde MA, Martin SS, Sun SX, Konstantopoulos K. Nat Commun. 2022 Oct 17;13(1):6128. doi: 10.1038/s41467-022-33683-1. PubMed |
| Darinaparsin (ZIO-101) enhances the sensitivity of small-cell lung cancer to PARP inhibitors. Cao GZ, Ma LY, Zhang ZH, Wang XL, Hua JH, Zhang JH, Lv Y, Zhang SB, Ou J, Lin WC. Acta Pharmacol Sin. 2023 Apr;44(4):841-852. doi: 10.1038/s41401-022-00994-4. Epub 2022 Oct 17. PubMed |
| Caspase-Mediated Regulation and Cellular Heterogeneity of the cGAS/STING Pathway in Kaposi's Sarcoma-Associated Herpesvirus Infection. Tabtieng T, Lent RC, Kaku M, Monago Sanchez A, Gaglia MM. mBio. 2022 Dec 20;13(6):e0244622. doi: 10.1128/mbio.02446-22. Epub 2022 Oct 18. PubMed |
| Spatial modeling reveals nuclear phosphorylation and subcellular shuttling of YAP upon drug-induced liver injury. Wehling L, Keegan L, Fernandez-Palanca P, Hassan R, Ghallab A, Schmitt J, Tang Y, Le Marois M, Roessler S, Schirmacher P, Kummer U, Hengstler JG, Sahle S, Breuhahn K. Elife. 2022 Oct 18;11:e78540. doi: 10.7554/eLife.78540. PubMed |
| A Genome-Wide CRISPR-Cas9 Loss-of-Function Screening to Identify Host Restriction Factors Modulating Oncolytic Virotherapy. Muscolini M, Hiscott J, Tassone E. Methods Mol Biol. 2023;2589:379-399. doi: 10.1007/978-1-0716-2788-4_25. PubMed |
| Generation of a bovine cell line for gene engineering using an HIV-1-based lentiviral vector. Morizako N, Butlertanaka EP, Tanaka YL, Shibata H, Okabayashi T, Mekata H, Saito A. Sci Rep. 2022 Oct 18;12(1):16952. doi: 10.1038/s41598-022-20970-6. PubMed |
| Circadian lncRNA ADIRF-AS1 binds PBAF and regulates renal clear cell tumorigenesis. Brooks R, Monzy J, Aaron B, Zhang X, Kossenkov A, Hayden J, Keeney F, Speicher DW, Zhang L, Dang CV. Cell Rep. 2022 Oct 18;41(3):111514. doi: 10.1016/j.celrep.2022.111514. PubMed |
| CASK loss of function differentially regulates neuronal maturation and synaptic function in human induced cortical excitatory neurons. McSweeney D, Gabriel R, Jin K, Pang ZP, Aronow B, Pak C. iScience. 2022 Sep 23;25(10):105187. doi: 10.1016/j.isci.2022.105187. eCollection 2022 Oct 21. PubMed |
| A Molecular Switch between Mammalian MLL Complexes Dictates Response to Menin-MLL Inhibition. Soto-Feliciano YM, Sanchez-Rivera FJ, Perner F, Barrows DW, Kastenhuber ER, Ho YJ, Carroll T, Xiong Y, Anand D, Soshnev AA, Gates L, Beytagh MC, Cheon D, Gu S, Liu XS, Krivtsov AV, Meneses M, de Stanchina E, Stone RM, Armstrong SA, Lowe SW, Allis CD. Cancer Discov. 2023 Jan 9;13(1):146-169. doi: 10.1158/2159-8290.CD-22-0416. PubMed |
| Non-enzymatic role of SOD1 in intestinal stem cell growth. Wang YC, Leng XX, Zhou CB, Lu SY, Tsang CK, Xu J, Zhang MM, Chen HM, Fang JY. Cell Death Dis. 2022 Oct 20;13(10):882. doi: 10.1038/s41419-022-05267-w. PubMed |
| KCNQ1OT1 promotes genome-wide transposon repression by guiding RNA-DNA triplexes and HP1 binding. Zhang X, Jiang Q, Li J, Zhang S, Cao Y, Xia X, Cai D, Tan J, Chen J, Han JJ. Nat Cell Biol. 2022 Nov;24(11):1617-1629. doi: 10.1038/s41556-022-01008-5. Epub 2022 Oct 20. PubMed |
| A bovine antibody possessing an ultralong complementarity-determining region CDRH3 targets a highly conserved epitope in sarbecovirus spike proteins. Burke MJ, Scott JNF, Minshull TC, Gao Z, Manfield I, Savic S, Stockley PG, Calabrese AN, Boyes J. J Biol Chem. 2022 Dec;298(12):102624. doi: 10.1016/j.jbc.2022.102624. Epub 2022 Oct 20. PubMed |
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| Hypoxic activation of PFKFB4 in breast tumor microenvironment shapes metabolic and cellular plasticity to accentuate metastatic competence. Dai T, Rosario SR, Katsuta E, Sawant Dessai A, Paterson EJ, Novickis AT, Cortes Gomez E, Zhu B, Liu S, Wang H, Abrams SI, Seshadri M, Bshara W, Dasgupta S. Cell Rep. 2022 Dec 6;41(10):111756. doi: 10.1016/j.celrep.2022.111756. PubMed |
| USP32-regulated LAMTOR1 ubiquitination impacts mTORC1 activation and autophagy induction. Hertel A, Alves LM, Dutz H, Tascher G, Bonn F, Kaulich M, Dikic I, Eimer S, Steinberg F, Bremm A. Cell Rep. 2022 Dec 6;41(10):111653. doi: 10.1016/j.celrep.2022.111653. PubMed |
| Close relatives of MERS-CoV in bats use ACE2 as their functional receptors. Xiong Q, Cao L, Ma C, Tortorici MA, Liu C, Si J, Liu P, Gu M, Walls AC, Wang C, Shi L, Tong F, Huang M, Li J, Zhao C, Shen C, Chen Y, Zhao H, Lan K, Corti D, Veesler D, Wang X, Yan H. Nature. 2022 Dec;612(7941):748-757. doi: 10.1038/s41586-022-05513-3. Epub 2022 Dec 7. PubMed |
| Extracellular Galectin 4 Drives Immune Evasion and Promotes T-cell Apoptosis in Pancreatic Cancer. Lidstrom T, Cumming J, Gaur R, Frangsmyr L, Pateras IS, Mickert MJ, Franklin O, Forsell MNE, Arnberg N, Dongre M, Patthey C, Ohlund D. Cancer Immunol Res. 2023 Jan 3;11(1):72-92. doi: 10.1158/2326-6066.CIR-21-1088. PubMed |
| Suppression of PD-L1 release from small extracellular vesicles promotes systemic anti-tumor immunity by targeting ORAI1 calcium channels. Chen X, Li J, Zhang R, Zhang Y, Wang X, Leung EL, Ma L, Wong VKW, Liu L, Neher E, Yu H. J Extracell Vesicles. 2022 Dec;11(12):e12279. doi: 10.1002/jev2.12279. PubMed |
| RUNX1 isoform disequilibrium promotes the development of trisomy 21-associated myeloid leukemia. Gialesaki S, Brauer-Hartmann D, Issa H, Bhayadia R, Alejo-Valle O, Verboon L, Schmell AL, Laszig S, Regenyi E, Schuschel K, Labuhn M, Ng M, Winkler R, Ihling C, Sinz A, Glass M, Huttelmaier S, Matzk S, Schmid L, Struwe FJ, Kadel SK, Reinhardt D, Yaspo ML, Heckl D, Klusmann JH. Blood. 2023 Mar 9;141(10):1105-1118. doi: 10.1182/blood.2022017619. PubMed |
| Stress-induced reversible cell-cycle arrest requires PRC2/PRC1-mediated control of mitophagy in Drosophila germline stem cells and human iPSCs. Taslim TH, Hussein AM, Keshri R, Ishibashi JR, Chan TC, Nguyen BN, Liu S, Brewer D, Harper S, Lyons S, Garver B, Dang J, Balachandar N, Jhajharia S, Castillo DD, Mathieu J, Ruohola-Baker H. Stem Cell Reports. 2023 Jan 10;18(1):269-288. doi: 10.1016/j.stemcr.2022.11.004. Epub 2022 Dec 8. PubMed |
| CRL2(ZER1/ZYG11B) recognizes small N-terminal residues for degradation. Li Y, Zhao Y, Yan X, Ye C, Weirich S, Zhang B, Wang X, Song L, Jiang C, Jeltsch A, Dong C, Mi W. Nat Commun. 2022 Dec 10;13(1):7636. doi: 10.1038/s41467-022-35169-6. PubMed |
| The STIM1/2-Regulated Calcium Homeostasis Is Impaired in Hippocampal Neurons of the 5xFAD Mouse Model of Alzheimer's Disease. Skobeleva K, Shalygin A, Mikhaylova E, Guzhova I, Ryazantseva M, Kaznacheyeva E. Int J Mol Sci. 2022 Nov 26;23(23):14810. doi: 10.3390/ijms232314810. PubMed |
| Transcription Factor-Forced Astrocytic Differentiation Impairs Human Glioblastoma Growth In Vitro and In Vivo. Trovato F, Stefani FR, Li J, Zetterdahl OG, Canals I, Ahlenius H, Bengzon J. Mol Cancer Ther. 2023 Feb 1;22(2):274-286. doi: 10.1158/1535-7163.MCT-21-0903. PubMed |
| Idarubicin combats abiraterone and enzalutamide resistance in prostate cells via targeting XPA protein. Zhang Y, Wei W, Li C, Yan S, Wang S, Xiao S, He C, Li J, Qi Z, Li B, Yang K, Li C. Cell Death Dis. 2022 Dec 12;13(12):1034. doi: 10.1038/s41419-022-05490-5. PubMed |
| HNF1B-driven three-dimensional chromatin structure for molecular classification in pancreatic cancers. Kato H, Tateishi K, Iwadate D, Yamamoto K, Fujiwara H, Nakatsuka T, Kudo Y, Hayakawa Y, Ijichi H, Otsuka M, Kishikawa T, Takahashi R, Miyabayashi K, Nakai Y, Hirata Y, Toyoda A, Morishita S, Fujishiro M. Cancer Sci. 2023 Apr;114(4):1672-1685. doi: 10.1111/cas.15690. Epub 2022 Dec 25. PubMed |
| A COL4A4-G394S Variant and Impaired Collagen IV Trimerization in a Patient with Mild Alport Syndrome. Kohler J, Omachi K, Charu V, Miner JH, Bhalla V. Kidney360. 2022 Oct 26;3(11):1899-1908. doi: 10.34067/KID.0005472022. eCollection 2022 Nov 24. PubMed |
| A fast-growing dengue virus mutant reveals a dual role of STING in response to infection. Ng WC, Kwek SS, Sun B, Yousefi M, Ong EZ, Tan HC, Puschnik AS, Chan KR, Ooi YS, Ooi EE. Open Biol. 2022 Dec;12(12):220227. doi: 10.1098/rsob.220227. Epub 2022 Dec 14. PubMed |
Macrophage NFATC2 mediates angiogenic signaling during mycobacterial infection.
Brewer WJ, Xet-Mull AM, Yu A, Sweeney MI, Walton EM, Tobin DM.
Cell Rep. 2022 Dec 13;41(11):111817. doi: 10.1016/j.celrep.2022.111817.
PubMed
Associated Plasmids |
Engineered cell entry links receptor biology with single-cell genomics.
Yu B, Shi Q, Belk JA, Yost KE, Parker KR, Li R, Liu BB, Huang H, Lingwood D, Greenleaf WJ, Davis MM, Satpathy AT, Chang HY.
Cell. 2022 Dec 22;185(26):4904-4920.e22. doi: 10.1016/j.cell.2022.11.016. Epub 2022 Dec 13.
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| HNF1B Alters an Evolutionarily Conserved Nephrogenic Program of Target Genes. Grand K, Stoltz M, Rizzo L, Rock R, Kaminski MM, Salinas G, Getwan M, Naert T, Pichler R, Lienkamp SS. J Am Soc Nephrol. 2023 Mar 1;34(3):412-432. doi: 10.1681/ASN.2022010076. Epub 2022 Dec 15. PubMed |
| KMT2D deficiency drives lung squamous cell carcinoma and hypersensitivity to RTK-RAS inhibition. Pan Y, Han H, Hu H, Wang H, Song Y, Hao Y, Tong X, Patel AS, Misirlioglu S, Tang S, Huang HY, Geng K, Chen T, Karatza A, Sherman F, Labbe KE, Yang F, Chafitz A, Peng C, Guo C, Moreira AL, Velcheti V, Lau SCM, Sui P, Chen H, Diehl JA, Rustgi AK, Bass AJ, Poirier JT, Zhang X, Ji H, Zhang H, Wong KK. Cancer Cell. 2023 Jan 9;41(1):88-105.e8. doi: 10.1016/j.ccell.2022.11.015. Epub 2022 Dec 15. PubMed |
| Data on cardiac lncRNA STX18-AS1 expression in developing human hearts and function during in vitro hESC-cardiomyocyte differentiation. Liu Y, Choy MK, Abraham S, Tenin G, Black GC, Keavney BD. Data Brief. 2022 Nov 21;45:108770. doi: 10.1016/j.dib.2022.108770. eCollection 2022 Dec. PubMed |
| Nsp1 proteins of human coronaviruses HCoV-OC43 and SARS-CoV2 inhibit stress granule formation. Dolliver SM, Kleer M, Bui-Marinos MP, Ying S, Corcoran JA, Khaperskyy DA. PLoS Pathog. 2022 Dec 19;18(12):e1011041. doi: 10.1371/journal.ppat.1011041. eCollection 2022 Dec. PubMed |
| NCK1 Modulates Neuronal Actin Dynamics and Promotes Dendritic Spine, Synapse, and Memory Formation. Diab AM, Wigerius M, Quinn DP, Qi J, Shahin I, Paffile J, Krueger K, Karten B, Krueger SR, Fawcett JP. J Neurosci. 2023 Feb 8;43(6):885-901. doi: 10.1523/JNEUROSCI.0495-21.2022. Epub 2022 Dec 19. PubMed |
| mTORC1 regulates a lysosome-dependent adaptive shift in intracellular lipid species. Hosios AM, Wilkinson ME, McNamara MC, Kalafut KC, Torrence ME, Asara JM, Manning BD. Nat Metab. 2022 Dec;4(12):1792-1811. doi: 10.1038/s42255-022-00706-6. Epub 2022 Dec 19. PubMed |
| Spurious transcription causing innate immune responses is prevented by 5-hydroxymethylcytosine. Wu F, Li X, Looso M, Liu H, Ding D, Gunther S, Kuenne C, Liu S, Weissmann N, Boettger T, Atzberger A, Kolahian S, Renz H, Offermanns S, Gartner U, Potente M, Zhou Y, Yuan X, Braun T. Nat Genet. 2023 Jan;55(1):100-111. doi: 10.1038/s41588-022-01252-3. Epub 2022 Dec 20. PubMed |
| Ras-mediated activation of mTORC2 promotes breast epithelial cell migration and invasion. Collins SE, Wiegand ME, Werner AN, Brown IN, Mundo MI, Swango DJ, Mouneimne G, Charest PG. Mol Biol Cell. 2023 Feb 1;34(2):ar9. doi: 10.1091/mbc.E22-06-0236. Epub 2022 Dec 21. PubMed |
| Alternative splicing liberates a cryptic cytoplasmic isoform of mitochondrial MECR that antagonizes influenza virus. Baker SF, Meistermann H, Tzouros M, Baker A, Golling S, Polster JS, Ledwith MP, Gitter A, Augustin A, Javanbakht H, Mehle A. PLoS Biol. 2022 Dec 21;20(12):e3001934. doi: 10.1371/journal.pbio.3001934. eCollection 2022 Dec. PubMed |
| A genome-wide CRISPR screen identifies CALCOCO2 as a regulator of beta cell function influencing type 2 diabetes risk. Rottner AK, Ye Y, Navarro-Guerrero E, Rajesh V, Pollner A, Bevacqua RJ, Yang J, Spigelman AF, Baronio R, Bautista A, Thomsen SK, Lyon J, Nawaz S, Smith N, Wesolowska-Andersen A, Fox JEM, Sun H, Kim SK, Ebner D, MacDonald PE, Gloyn AL. Nat Genet. 2023 Jan;55(1):54-65. doi: 10.1038/s41588-022-01261-2. Epub 2022 Dec 21. PubMed |
| A conformation-specific nanobody targeting the nicotinamide mononucleotide-activated state of SARM1. Hou YN, Cai Y, Li WH, He WM, Zhao ZY, Zhu WJ, Wang Q, Mai X, Liu J, Lee HC, Stjepanovic G, Zhang H, Zhao YJ. Nat Commun. 2022 Dec 22;13(1):7898. doi: 10.1038/s41467-022-35581-y. PubMed |
| ACTR5 controls CDKN2A and tumor progression in an INO80-independent manner. Xu X, Chan AKN, Li M, Liu Q, Mattson N, Pangeni Pokharel S, Chang WH, Yuan YC, Wang J, Moore RE, Pirrotte P, Wu J, Su R, Muschen M, Rosen ST, Chen J, Yang L, Chen CW. Sci Adv. 2022 Dec 23;8(51):eadc8911. doi: 10.1126/sciadv.adc8911. Epub 2022 Dec 23. PubMed |
A Ubiquitination Cascade Regulating the Integrated Stress Response and Survival in Carcinomas.
Cervia LD, Shibue T, Borah AA, Gaeta B, He L, Leung L, Li N, Moyer SM, Shim BH, Dumont N, Gonzalez A, Bick NR, Kazachkova M, Dempster JM, Krill-Burger JM, Piccioni F, Udeshi ND, Olive ME, Carr SA, Root DE, McFarland JM, Vazquez F, Hahn WC.
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PubMed
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| The US9-Derived Protein gPTB9TM Modulates APP Processing Without Targeting Secretase Activities. Brandimarti R, Irollo E, Meucci O. Mol Neurobiol. 2023 Apr;60(4):1811-1825. doi: 10.1007/s12035-022-03153-2. Epub 2022 Dec 28. PubMed |
| The lncRNA LUCAT1 is elevated in inflammatory disease and restrains inflammation by regulating the splicing and stability of NR4A2. Vierbuchen T, Agarwal S, Johnson JL, Galia L, Lei X, Stein K, Olagnier D, Gaede KI, Herzmann C, Holm CK, Heine H, Pai A, O'Hara Hall A, Hoebe K, Fitzgerald KA. Proc Natl Acad Sci U S A. 2023 Jan 3;120(1):e2213715120. doi: 10.1073/pnas.2213715120. Epub 2022 Dec 28. PubMed |
| SARS-CoV-2 replication in airway epithelia requires motile cilia and microvillar reprogramming. Wu CT, Lidsky PV, Xiao Y, Cheng R, Lee IT, Nakayama T, Jiang S, He W, Demeter J, Knight MG, Turn RE, Rojas-Hernandez LS, Ye C, Chiem K, Shon J, Martinez-Sobrido L, Bertozzi CR, Nolan GP, Nayak JV, Milla C, Andino R, Jackson PK. Cell. 2023 Jan 5;186(1):112-130.e20. doi: 10.1016/j.cell.2022.11.030. Epub 2022 Dec 2. PubMed |
| Identification of 5' upstream sequence involved in HSPBP1 gene transcription and its downregulation during HIV-1 infection. Iyer K, Mitra A, Mitra D. Virus Res. 2023 Jan 15;324:199034. doi: 10.1016/j.virusres.2022.199034. Epub 2022 Dec 26. PubMed |
| Generation of Induced Pluripotent Stem Cells from Lymphoblastoid Cell Lines by Electroporation of Episomal Vectors. Kim M, Park J, Kim S, Han DW, Shin B, Scholer HR, Kim J, Kim KP. Int J Stem Cells. 2023 Feb 28;16(1):36-43. doi: 10.15283/ijsc22177. Epub 2022 Dec 31. PubMed |
| High p62 expression suppresses the NLRP1 inflammasome and increases stress resistance in cutaneous SCC cells. Hennig P, Di Filippo M, Bilfeld G, Mellett M, Beer HD. Cell Death Dis. 2022 Dec 29;13(12):1077. doi: 10.1038/s41419-022-05530-0. PubMed |
| p53 regulates lysosomal membrane permeabilization as well as cytoprotective autophagy in response to DNA-damaging drugs. Yamashita G, Takano N, Kazama H, Tsukahara K, Miyazawa K. Cell Death Discov. 2022 Dec 29;8(1):502. doi: 10.1038/s41420-022-01293-x. PubMed |
| Fine-grained, nonlinear registration of live cell movies reveals spatiotemporal organization of diffuse molecular processes. Jiang X, Isogai T, Chi J, Danuser G. PLoS Comput Biol. 2022 Dec 30;18(12):e1009667. doi: 10.1371/journal.pcbi.1009667. eCollection 2022 Dec. PubMed |
| Mapping of functional SARS-CoV-2 receptors in human lungs establishes differences in variant binding and SLC1A5 as a viral entry modulator of hACE2. Miluzio A, Cuomo A, Cordiglieri C, Donnici L, Pesce E, Bombaci M, Conti M, Fasciani A, Terracciano L, Manganaro L, Toccafondi M, Scagliola A, Oliveto S, Ricciardi S, Grifantini R, De Francesco R, Abrignani S, Manfrini N, Biffo S. EBioMedicine. 2023 Jan;87:104390. doi: 10.1016/j.ebiom.2022.104390. Epub 2022 Dec 28. PubMed |
| Genetic and pharmacological modulation of DNA mismatch repair heterogeneous tumors promotes immune surveillance. Amodio V, Lamba S, Chila R, Cattaneo CM, Mussolin B, Corti G, Rospo G, Berrino E, Tripodo C, Pisati F, Bartolini A, Aquilano MC, Marsoni S, Mauri G, Marchio C, Abrignani S, Di Nicolantonio F, Germano G, Bardelli A. Cancer Cell. 2023 Jan 9;41(1):196-209.e5. doi: 10.1016/j.ccell.2022.12.003. Epub 2022 Dec 29. PubMed |
| Virus-like particle - mediated delivery of the RIG-I agonist M8 induces a type I interferon response and protects cells against viral infection. Palermo E, Alexandridi M, Di Carlo D, Muscolini M, Hiscott J. Front Cell Infect Microbiol. 2022 Dec 14;12:1079926. doi: 10.3389/fcimb.2022.1079926. eCollection 2022. PubMed |
| Expression of TRX1 optimizes the antitumor functions of human CAR T cells and confers resistance to a pro-oxidative tumor microenvironment. Balta E, Janzen N, Kirchgessner H, Toufaki V, Orlik C, Liang J, Lairikyengbam D, Abken H, Niesler B, Muller-Decker K, Ruppert T, Samstag Y. Front Immunol. 2022 Dec 14;13:1063313. doi: 10.3389/fimmu.2022.1063313. eCollection 2022. PubMed |
| RUNX2 stabilization by long non-coding RNAs contributes to hypertrophic changes in human chondrocytes. Yoon DS, Kim EJ, Cho S, Jung S, Lee KM, Park KH, Lee JW, Kim SH. Int J Biol Sci. 2023 Jan 1;19(1):13-33. doi: 10.7150/ijbs.74895. eCollection 2023. PubMed |
| Mouse embryonic stem cell-derived motor neurons are susceptible to ferroptosis. Martinez AM, Kim A, Flores CA, Rahman DF, Yang WS. FEBS Open Bio. 2023 Mar;13(3):419-433. doi: 10.1002/2211-5463.13545. Epub 2023 Jan 24. PubMed |
| Sec22b is a critical and nonredundant regulator of plasma cell maintenance. Bonaud A, Gargowitsch L, Gilbert SM, Rajan E, Canales-Herrerias P, Stockholm D, Rahman NF, Collins MO, Taskiran H, Hill DL, Alloatti A, Alouche N, Balor S, Soldan V, Gillet D, Barbier J, Bachelerie F, Smith KGC, Jellusova J, Bruhns P, Amigorena S, Balabanian K, Linterman MA, Peden AA, Espeli M. Proc Natl Acad Sci U S A. 2023 Jan 10;120(2):e2213056120. doi: 10.1073/pnas.2213056120. Epub 2023 Jan 3. PubMed |
| MicroRNA-1 attenuates the growth and metastasis of small cell lung cancer through CXCR4/FOXM1/RRM2 axis. Khan P, Siddiqui JA, Kshirsagar PG, Venkata RC, Maurya SK, Mirzapoiazova T, Perumal N, Chaudhary S, Kanchan RK, Fatima M, Khan MA, Rehman AU, Lakshmanan I, Mahapatra S, Talmon GA, Kulkarni P, Ganti AK, Jain M, Salgia R, Batra SK, Nasser MW. Mol Cancer. 2023 Jan 4;22(1):1. doi: 10.1186/s12943-022-01695-6. PubMed |
| PAQR8 promotes breast cancer recurrence and confers resistance to multiple therapies. Chen S, Paul MR, Sterner CJ, Belka GK, Wang D, Xu P, Sreekumar A, Pan TC, Pant DK, Makhlin I, DeMichele A, Mesaros C, Chodosh LA. Breast Cancer Res. 2023 Jan 3;25(1):1. doi: 10.1186/s13058-022-01559-3. PubMed |
| beta-Catenin activity induces an RNA biosynthesis program promoting therapy resistance in T-cell acute lymphoblastic leukemia. Garcia-Hernandez V, Arambilet D, Guillen Y, Lobo-Jarne T, Maqueda M, Gekas C, Gonzalez J, Iglesias A, Vega-Garcia N, Sentis I, Trincado JL, Marquez-Lopez I, Heyn H, Camos M, Espinosa L, Bigas A. EMBO Mol Med. 2023 Feb 8;15(2):e16554. doi: 10.15252/emmm.202216554. Epub 2023 Jan 4. PubMed |
Small Molecule-Activated O-GlcNAcase for Spatiotemporal Removal of O-GlcNAc in Live Cells.
Ge Y, Lu H, Yang B, Woo CM.
ACS Chem Biol. 2023 Jan 4. doi: 10.1021/acschembio.2c00894.
PubMed
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| CLASP2 recognizes tubulins exposed at the microtubule plus-end in a nucleotide state-sensitive manner. Luo W, Demidov V, Shen Q, Girao H, Chakraborty M, Maiorov A, Ataullakhanov FI, Lin C, Maiato H, Grishchuk EL. Sci Adv. 2023 Jan 4;9(1):eabq5404. doi: 10.1126/sciadv.abq5404. Epub 2023 Jan 4. PubMed |
| FHL3 promotes the formation of fast glycolytic muscle fibers by interacting with YY1 and muscle glycolytic metabolism. Bai W, Zhang Y, Ma J, Du M, Xu H, Wang J, Zhang L, Li W, Hou Y, Liu X, Zhang X, Peng Y, Li J, Zhan X, Jiang W, Liu S, Liu X, Li Q, Miao Y, Sui M, Yang Y, Zhang S, Xu Z, Zuo B. Cell Mol Life Sci. 2023 Jan 5;80(1):27. doi: 10.1007/s00018-022-04680-w. PubMed |
| Nuclear accumulation of host transcripts during Zika Virus Infection. Leon KE, Khalid MM, Flynn RA, Fontaine KA, Nguyen TT, Kumar GR, Simoneau CR, Tomar S, Jimenez-Morales D, Dunlap M, Kaye J, Shah PS, Finkbeiner S, Krogan NJ, Bertozzi C, Carette JE, Ott M. PLoS Pathog. 2023 Jan 5;19(1):e1011070. doi: 10.1371/journal.ppat.1011070. eCollection 2023 Jan. PubMed |
| Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome. Unda BK, Chalil L, Yoon S, Kilpatrick S, Irwin C, Xing S, Murtaza N, Cheng A, Brown C, Afonso A, McCready E, Ronen GM, Howe J, Caye-Eude A, Verloes A, Doble BW, Faivre L, Vitobello A, Scherer SW, Lu Y, Penzes P, Singh KK. Mol Psychiatry. 2023 Jan 6. doi: 10.1038/s41380-022-01937-5. PubMed |
| Efficient and error-free correction of sickle mutation in human erythroid cells using prime editor-2. George A, Ravi NS, Prasad K, Panigrahi L, Koikkara S, Rajendiran V, Devaraju N, Paul J, Pai AA, Nakamura Y, Kurita R, Balasubramanian P, Thangavel S, Marepally S, Velayudhan SR, Srivastava A, Mohankumar KM. Front Genome Ed. 2022 Dec 20;4:1085111. doi: 10.3389/fgeed.2022.1085111. eCollection 2022. PubMed |
| Proximity biotinylation to define the local environment of the protein kinase A catalytic subunit in adrenal cells. Omar MH, Lauer SM, Lau HT, Golkowski M, Ong SE, Scott JD. STAR Protoc. 2023 Jan 4;4(1):101992. doi: 10.1016/j.xpro.2022.101992. PubMed |
| Integrative characterisation of secreted factors involved in intercellular communication between prostate epithelial or cancer cells and fibroblasts. Wu Y, Clark KC, Niranjan B, Chueh AC, Horvath LG, Taylor RA, Daly RJ. Mol Oncol. 2023 Mar;17(3):469-486. doi: 10.1002/1878-0261.13376. Epub 2023 Jan 27. PubMed |
| METTL16 drives leukemogenesis and leukemia stem cell self-renewal by reprogramming BCAA metabolism. Han L, Dong L, Leung K, Zhao Z, Li Y, Gao L, Chen Z, Xue J, Qing Y, Li W, Pokharel SP, Gao M, Chen M, Shen C, Tan B, Small A, Wang K, Zhang Z, Qin X, Yang L, Wunderlich M, Zhang B, Mulloy JC, Marcucci G, Chen CW, Wei M, Su R, Chen J, Deng X. Cell Stem Cell. 2023 Jan 5;30(1):52-68.e13. doi: 10.1016/j.stem.2022.12.006. PubMed |
| Antagonistic action of GPS2 and KDM1A at enhancers governs alternative macrophage activation by interleukin 4. Huang Z, Efthymiadou A, Liang N, Fan R, Treuter E. Nucleic Acids Res. 2023 Feb 22;51(3):1067-1086. doi: 10.1093/nar/gkac1230. PubMed |
| Alternative splicing mediates the compensatory upregulation of MBNL2 upon MBNL1 loss-of-function. Nitschke L, Hu RC, Miller AN, Lucas L, Cooper TA. Nucleic Acids Res. 2023 Feb 22;51(3):1245-1259. doi: 10.1093/nar/gkac1219. PubMed |
| ERK phosphorylation disrupts the intramolecular interaction of capicua to promote cytoplasmic translocation of capicua and tumor growth. Park J, Park GY, Lee J, Park J, Kim S, Kim E, Park SY, Yoon JH, Lee Y. Front Mol Biosci. 2022 Dec 22;9:1030725. doi: 10.3389/fmolb.2022.1030725. eCollection 2022. PubMed |
| The mitophagy receptor BNIP3 is critical for the regulation of metabolic homeostasis and mitochondrial function in the nucleus pulposus cells of the intervertebral disc. Madhu V, Hernandez-Meadows M, Boneski PK, Qiu Y, Guntur AR, Kurland IJ, Barve RA, Risbud MV. Autophagy. 2023 Jun;19(6):1821-1843. doi: 10.1080/15548627.2022.2162245. Epub 2023 Jan 10. PubMed |
| MicroRNA-eQTLs in the developing human neocortex link miR-4707-3p expression to brain size. Lafferty MJ, Aygun N, Patel NK, Krupa O, Liang D, Wolter JM, Geschwind DH, de la Torre-Ubieta L, Stein JL. Elife. 2023 Jan 11;12:e79488. doi: 10.7554/eLife.79488. PubMed |
| Cytokinesis machinery promotes cell dissociation from collectively migrating strands in confinement. Law RA, Kiepas A, Desta HE, Perez Ipina E, Parlani M, Lee SJ, Yankaskas CL, Zhao R, Mistriotis P, Wang N, Gu Z, Kalab P, Friedl P, Camley BA, Konstantopoulos K. Sci Adv. 2023 Jan 13;9(2):eabq6480. doi: 10.1126/sciadv.abq6480. Epub 2023 Jan 11. PubMed |
| ZNF185 prevents stress fiber formation through the inhibition of RhoA in endothelial cells. Suzuki S, Ando F, Kitagawa S, Hara Y, Fujiki T, Mandai S, Susa K, Mori T, Sohara E, Rai T, Uchida S. Commun Biol. 2023 Jan 11;6(1):29. doi: 10.1038/s42003-023-04416-x. PubMed |
| Upregulation of LRRC8A by m(5)C modification-mediated mRNA stability suppresses apoptosis and facilitates tumorigenesis in cervical cancer. Chen Y, Zuo X, Wei Q, Xu J, Liu X, Liu S, Wang H, Luo Q, Wang Y, Yang Y, Zhao H, Xu J, Liu T, Yi P. Int J Biol Sci. 2023 Jan 1;19(2):691-704. doi: 10.7150/ijbs.79205. eCollection 2023. PubMed |
| PRR14 organizes H3K9me3-modified heterochromatin at the nuclear lamina. Kiseleva AA, Cheng YC, Smith CL, Katz RA, Poleshko A. Nucleus. 2023 Dec;14(1):2165602. doi: 10.1080/19491034.2023.2165602. PubMed |
| Loss of RREB1 in pancreatic beta cells reduces cellular insulin content and affects endocrine cell gene expression. Mattis KK, Krentz NAJ, Metzendorf C, Abaitua F, Spigelman AF, Sun H, Ikle JM, Thaman S, Rottner AK, Bautista A, Mazzaferro E, Perez-Alcantara M, Manning Fox JE, Torres JM, Wesolowska-Andersen A, Yu GZ, Mahajan A, Larsson A, MacDonald PE, Davies B, den Hoed M, Gloyn AL. Diabetologia. 2023 Apr;66(4):674-694. doi: 10.1007/s00125-022-05856-6. Epub 2023 Jan 12. PubMed |
| Exosomes mediate Coxsackievirus B3 transmission and expand the viral tropism. Fu Y, Xiong S. PLoS Pathog. 2023 Jan 12;19(1):e1011090. doi: 10.1371/journal.ppat.1011090. eCollection 2023 Jan. PubMed |
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Predicting prime editing efficiency and product purity by deep learning.
Mathis N, Allam A, Kissling L, Marquart KF, Schmidheini L, Solari C, Balazs Z, Krauthammer M, Schwank G.
Nat Biotechnol. 2023 Jan 16. doi: 10.1038/s41587-022-01613-7.
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| A RIPK3-independent role of MLKL in suppressing parthanatos promotes immune evasion in hepatocellular carcinoma. Jiang X, Deng W, Tao S, Tang Z, Chen Y, Tian M, Wang T, Tao C, Li Y, Fang Y, Pu C, Gao J, Wang X, Qu W, Gai X, Ding Z, Fu Y, Zheng Y, Cao S, Zhou J, Huang M, Liu W, Xu J, Fan J, Shi Y. Cell Discov. 2023 Jan 17;9(1):7. doi: 10.1038/s41421-022-00504-0. PubMed |
| CRISPR screens reveal genetic determinants of PARP inhibitor sensitivity and resistance in prostate cancer. Tsujino T, Takai T, Hinohara K, Gui F, Tsutsumi T, Bai X, Miao C, Feng C, Gui B, Sztupinszki Z, Simoneau A, Xie N, Fazli L, Dong X, Azuma H, Choudhury AD, Mouw KW, Szallasi Z, Zou L, Kibel AS, Jia L. Nat Commun. 2023 Jan 17;14(1):252. doi: 10.1038/s41467-023-35880-y. PubMed |
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| Jatrophane Diterpenoids from Euphorbia peplus Linn. as Activators of Autophagy and Inhibitors of Tau Pathology. Yan Y, Zhou Q, Ran X, Lu Q, Zhang C, Peng M, Tang L, Luo R, Di Y, Hao X. Int J Mol Sci. 2023 Jan 6;24(2):1088. doi: 10.3390/ijms24021088. PubMed |
| A Missense Variation in PHACTR2 Associates with Impaired Actin Dynamics, Dilated Cardiomyopathy, and Left Ventricular Non-Compaction in Humans. Majdalani P, Levitas A, Krymko H, Slanovic L, Braiman A, Hadad U, Dabsan S, Horev A, Zarivach R, Parvari R. Int J Mol Sci. 2023 Jan 10;24(2):1388. doi: 10.3390/ijms24021388. PubMed |
| Epigenomic charting and functional annotation of risk loci in renal cell carcinoma. Nassar AH, Abou Alaiwi S, Baca SC, Adib E, Corona RI, Seo JH, Fonseca MAS, Spisak S, El Zarif T, Tisza V, Braun DA, Du H, He M, Flaifel A, Alchoueiry M, Denize T, Matar SG, Acosta A, Shukla S, Hou Y, Steinharter J, Bouchard G, Berchuck JE, O'Connor E, Bell C, Nuzzo PV, Mary Lee GS, Signoretti S, Hirsch MS, Pomerantz M, Henske E, Gusev A, Lawrenson K, Choueiri TK, Kwiatkowski DJ, Freedman ML. Nat Commun. 2023 Jan 21;14(1):346. doi: 10.1038/s41467-023-35833-5. PubMed |
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| Ganoapplins A and B with an unprecedented 6/6/6/5/6-fused pentacyclic skeleton from Ganoderma inhibit Tau pathology through activating autophagy. Peng X, Luo R, Ran X, Guo Y, Yao YG, Qiu M. Bioorg Chem. 2023 Mar;132:106375. doi: 10.1016/j.bioorg.2023.106375. Epub 2023 Jan 17. PubMed |
| SARS-CoV-2 Spike protein activates TMEM16F-mediated platelet procoagulant activity. Cappelletto A, Allan HE, Crescente M, Schneider E, Bussani R, Ali H, Secco I, Vodret S, Simeone R, Mascaretti L, Zacchigna S, Warner TD, Giacca M. Front Cardiovasc Med. 2023 Jan 4;9:1013262. doi: 10.3389/fcvm.2022.1013262. eCollection 2022. PubMed |
| Abl2 Kinase Differentially Regulates iGluRs Current Activity and Synaptic Localization. Kabirova M, Reichenstein M, Borovok N, Sheinin A, Gorobets D, Michaelevski I. Cell Mol Neurobiol. 2023 Aug;43(6):2785-2799. doi: 10.1007/s10571-023-01317-9. Epub 2023 Jan 23. PubMed |
| Destabilizing NF1 variants act in a dominant negative manner through neurofibromin dimerization. Young LC, Goldstein de Salazar R, Han SW, Huang ZYS, Merk A, Drew M, Darling J, Wall V, Grisshammer R, Cheng A, Allison MR, Sale MJ, Nissley DV, Esposito D, Ognjenovic J, McCormick F. Proc Natl Acad Sci U S A. 2023 Jan 31;120(5):e2208960120. doi: 10.1073/pnas.2208960120. Epub 2023 Jan 23. PubMed |
Attenuating iPSC reprogramming stress with dominant-negative BET peptides.
Hossain ME, Cevallos RR, Zhang R, Hu K.
iScience. 2022 Dec 28;26(1):105889. doi: 10.1016/j.isci.2022.105889. eCollection 2023 Jan 20.
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| Human VH-based chimeric antigen receptor T cells targeting glypican 3 eliminate tumors in preclinical models of HCC. Kolluri A, Li D, Li N, Duan Z, Roberts LR, Ho M. Hepatol Commun. 2023 Jan 18;7(2):e0022. doi: 10.1097/HC9.0000000000000022. eCollection 2023 Feb 1. PubMed |
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| Lamin A/C phosphorylation at serine 22 is a conserved heat shock response to regulate nuclear adaptation during stress. Virtanen L, Holm E, Halme M, West G, Lindholm F, Gullmets J, Irjala J, Helio T, Padzik A, Meinander A, Eriksson JE, Taimen P. J Cell Sci. 2023 Feb 15;136(4):jcs259788. doi: 10.1242/jcs.259788. Epub 2023 Feb 27. PubMed |
| Secreted PGK1 and IGFBP2 contribute to the bystander effect of miR-10b gene editing in glioma. Zhang Y, Rabinovsky R, Wei Z, El Fatimy R, Deforzh E, Luan B, Peshkin L, Uhlmann EJ, Krichevsky AM. Mol Ther Nucleic Acids. 2023 Jan 2;31:265-275. doi: 10.1016/j.omtn.2022.12.018. eCollection 2023 Mar 14. PubMed |
| The frequency of differentiated CD3(+)CD27(-)CD28(-) T cells predicts response to CART cell therapy in diffuse large B-cell lymphoma. Worel N, Grabmeier-Pfistershammer K, Kratzer B, Schlager M, Tanzmann A, Rottal A, Kormoczi U, Porpaczy E, Staber PB, Skrabs C, Herkner H, Gudipati V, Huppa JB, Salzer B, Lehner M, Saxenhuber N, Friedberg E, Wohlfarth P, Hopfinger G, Rabitsch W, Simonitsch-Klupp I, Jager U, Pickl WF. Front Immunol. 2023 Jan 9;13:1004703. doi: 10.3389/fimmu.2022.1004703. eCollection 2022. PubMed |
| The endothelial-enriched lncRNA LINC00607 mediates angiogenic function. Boos F, Oo JA, Warwick T, Gunther S, Izquierdo Ponce J, Lopez M, Rafii D, Buchmann G, Pham MD, Msheik ZS, Li T, Seredinski S, Haydar S, Kashefiolasl S, Plate KH, Behr R, Mietsch M, Krishnan J, Pullamsetti SS, Bibli SI, Hinkel R, Baker AH, Boon RA, Schulz MH, Wittig I, Miller FJ Jr, Brandes RP, Leisegang MS. Basic Res Cardiol. 2023 Jan 26;118(1):5. doi: 10.1007/s00395-023-00978-3. PubMed |
| MiR-130b modulates the invasive, migratory, and metastatic behavior of leiomyosarcoma. Danielson LS, Guijarro MV, Menendez S, Higgins B, Sun Q, Mittal K, Popiolek DA, Overholtzer M, Palmer GD, Hernando E. PLoS One. 2023 Jan 26;18(1):e0278844. doi: 10.1371/journal.pone.0278844. eCollection 2023. PubMed |
| A modular CRISPR screen identifies individual and combination pathways contributing to HIV-1 latency. Hsieh E, Janssens DH, Paddison PJ, Browne EP, Henikoff S, OhAinle M, Emerman M. PLoS Pathog. 2023 Jan 27;19(1):e1011101. doi: 10.1371/journal.ppat.1011101. eCollection 2023 Jan. PubMed |
| MANF stimulates autophagy and restores mitochondrial homeostasis to treat toxic proteinopathy. Kim Y, Li C, Gu C, Tycksen E, Puri A, Pietka TA, Sivapackiam J, Fang Y, Kidd K, Park SJ, Johnson BG, Kmoch S, Duffield JS, Bleyer AJ, Jackrel ME, Urano F, Sharma V, Lindahl M, Chen YM. bioRxiv [Preprint]. 2023 Jan 12:2023.01.10.523171. doi: 10.1101/2023.01.10.523171. PubMed |
| EHD1-dependent traffic of IGF-1 receptor to the cell surface is essential for Ewing sarcoma tumorigenesis and metastasis. Chakraborty S, Bhat AM, Mushtaq I, Luan H, Kalluchi A, Mirza S, Storck MD, Chaturvedi N, Lopez-Guerrero JA, Llombart-Bosch A, Machado I, Scotlandi K, Meza JL, Ghosal G, Coulter DW, Rowley JM, Band V, Mohapatra BC, Band H. bioRxiv. 2023 Mar 22:2023.01.15.524130. doi: 10.1101/2023.01.15.524130. Preprint. PubMed |
| Coupling During Collective Cell Migration is Controlled by a Vinculin Mechanochemical Switch. Shoyer TC, Gates EM, Cabe JI, Conway DE, Hoffman BD. bioRxiv. 2023 Jan 14:2023.01.13.523997. doi: 10.1101/2023.01.13.523997. Preprint. PubMed |
| Elucidation of the Molecular Basis and Cellular Functions of Vinculin-Actin Directional Catch Bonding. Campbell S, Chirasani V, Khan M, Malavade J, Dokholyan N, Hoffman B. Res Sq. 2023 Jan 12:rs.3.rs-2334490. doi: 10.21203/rs.3.rs-2334490/v1. Preprint. PubMed |
| TSC2 regulates tumor susceptibility to TRAIL-mediated T-cell killing by orchestrating mTOR signaling. Lin CP, Traets JJH, Vredevoogd DW, Visser NL, Peeper DS. EMBO J. 2023 Mar 1;42(5):e111614. doi: 10.15252/embj.2022111614. Epub 2023 Jan 30. PubMed |
| LKB1-Dependent Regulation of TPI1 Creates a Divergent Metabolic Liability between Human and Mouse Lung Adenocarcinoma. Stein BD, Ferrarone JR, Gardner EE, Chang JW, Wu D, Hollstein PE, Liang RJ, Yuan M, Chen Q, Coukos JS, Sindelar M, Ngo B, Gross SS, Shaw RJ, Zhang C, Asara JM, Moellering RE, Varmus H, Cantley LC. Cancer Discov. 2023 Apr 3;13(4):1002-1025. doi: 10.1158/2159-8290.CD-22-0805. PubMed |
| YAP1 and WWTR1 expression inversely correlates with neuroendocrine markers in Merkel cell carcinoma. Frost TC, Gartin AK, Liu M, Cheng J, Dharaneeswaran H, Keskin DB, Wu CJ, Giobbie-Hurder A, Thakuria M, DeCaprio JA. J Clin Invest. 2023 Mar 1;133(5):e157171. doi: 10.1172/JCI157171. PubMed |
| KDM6 demethylases integrate DNA repair gene regulation and loss of KDM6A sensitizes human acute myeloid leukemia to PARP and BCL2 inhibition. Boila LD, Ghosh S, Bandyopadhyay SK, Jin L, Murison A, Zeng AGX, Shaikh W, Bhowmik S, Muddineni SSNA, Biswas M, Sinha S, Chatterjee SS, Mbong N, Gan OI, Bose A, Chakraborty S, Arruda A, Kennedy JA, Mitchell A, Lechman ER, Banerjee D, Milyavsky M, Minden MD, Dick JE, Sengupta A. Leukemia. 2023 Jan 31. doi: 10.1038/s41375-023-01833-z. PubMed |
| A genome-wide CRISPR functional survey of the human phagocytosis molecular machinery. Essletzbichler P, Sedlyarov V, Frommelt F, Soulat D, Heinz LX, Stefanovic A, Neumayer B, Superti-Furga G. Life Sci Alliance. 2023 Feb 1;6(4):e202201715. doi: 10.26508/lsa.202201715. Print 2023 Apr. PubMed |
| Skeletal diseases caused by mutations in PTH1R show aberrant differentiation of skeletal progenitors due to dysregulation of DEPTOR. Csukasi F, Bosakova M, Barta T, Martin JH, Arcedo J, Barad M, Rico-Llanos GA, Zieba J, Becerra J, Krejci P, Duran I, Krakow D. Front Cell Dev Biol. 2023 Jan 16;10:963389. doi: 10.3389/fcell.2022.963389. eCollection 2022. PubMed |
| Species-specific regulation of XIST by the JPX/FTX orthologs. Rosspopoff O, Cazottes E, Huret C, Loda A, Collier AJ, Casanova M, Rugg-Gunn PJ, Heard E, Ouimette JF, Rougeulle C. Nucleic Acids Res. 2023 Mar 21;51(5):2177-2194. doi: 10.1093/nar/gkad029. PubMed |
| Molecular characterization of human cytomegalovirus infection with single-cell transcriptomics. Schwartz M, Shnayder M, Nachshon A, Arazi T, Kitsberg Y, Levi Samia R, Lavi M, Kuint R, Tsabari R, Stern-Ginossar N. Nat Microbiol. 2023 Mar;8(3):455-468. doi: 10.1038/s41564-023-01325-x. Epub 2023 Feb 2. PubMed |
Spatial regulation of the glycocalyx component podocalyxin is a switch for prometastatic function.
Roman-Fernandez A, Mansour MA, Kugeratski FG, Anand J, Sandilands E, Galbraith L, Rakovic K, Freckmann EC, Cumming EM, Park J, Nikolatou K, Lilla S, Shaw R, Strachan D, Mason S, Patel R, McGarry L, Katoch A, Campbell KJ, Nixon C, Miller CJ, Leung HY, Le Quesne J, Norman JC, Zanivan S, Blyth K, Bryant DM.
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| Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity. Golkowski M, Lius A, Sapre T, Lau HT, Moreno T, Maly DJ, Ong SE. Mol Cell. 2023 Mar 2;83(5):803-818.e8. doi: 10.1016/j.molcel.2023.01.015. Epub 2023 Feb 2. PubMed |
| Crk proteins activate the Rap1 guanine nucleotide exchange factor C3G by segregated adaptor-dependent and -independent mechanisms. Rodriguez-Blazquez A, Carabias A, Moran-Vaquero A, de Cima S, Luque-Ortega JR, Alfonso C, Schuck P, Manso JA, Macedo-Ribeiro S, Guerrero C, de Pereda JM. Cell Commun Signal. 2023 Feb 3;21(1):30. doi: 10.1186/s12964-023-01042-2. PubMed |
| A Virus-Packageable CRISPR System Identifies Host Dependency Factors Co-Opted by Multiple HIV-1 Strains. Montoya VR, Ready TM, Felton A, Fine SR, OhAinle M, Emerman M. mBio. 2023 Feb 28;14(1):e0000923. doi: 10.1128/mbio.00009-23. Epub 2023 Feb 6. PubMed |
| Notch1 cortical signaling regulates epithelial architecture and cell-cell adhesion. White MJ, Jacobs KA, Singh T, Kutys ML. bioRxiv. 2023 Jan 23:2023.01.23.524428. doi: 10.1101/2023.01.23.524428. Preprint. PubMed |
| Nuclease-dead S. aureus Cas9 downregulates alpha-synuclein and reduces mtDNA damage and oxidative stress levels in patient-derived stem cell model of Parkinson's disease. Sastre D, Zafar F, Torres CAM, Piper D, Kirik D, Sanders LH, Qi S, Schule B. bioRxiv. 2023 Jan 24:2023.01.24.525105. doi: 10.1101/2023.01.24.525105. Preprint. PubMed |
| Prdm6 drives ductus arteriosus closure by promoting ductus arteriosus smooth muscle cell identity and contractility. Zou M, Mangum KD, Magin JC, Cao HH, Yarboro MT, Shelton EL, Taylor JM, Reese J, Furey TS, Mack CP. JCI Insight. 2023 Mar 8;8(5):e163454. doi: 10.1172/jci.insight.163454. PubMed |
| A rabies virus-based toolkit for efficient retrograde labeling and monosynaptic tracing. Lin KZ, Li L, Ma WY, Yang X, Han ZP, Luo NS, Wang J, Xu FQ. Neural Regen Res. 2023 Aug;18(8):1827-1833. doi: 10.4103/1673-5374.358618. PubMed |
| Murine Gammaherpesvirus 68 ORF45 Stimulates B2 Retrotransposon and Pre-tRNA Activation in a Manner Dependent on Mitogen-Activated Protein Kinase (MAPK) Signaling. Lari A, Glaunsinger BA. Microbiol Spectr. 2023 Feb 8:e0017223. doi: 10.1128/spectrum.00172-23. PubMed |
| PP2Ac/STRN4 negatively regulates STING-type I IFN signaling in tumor-associated macrophages. Ho WS, Mondal I, Xu B, Das O, Sun R, Chiou P, Cai X, Tahmasebinia F, McFadden E, Wu CY, Wu Z, Matsui W, Lim M, Meng Z, Lu RO. J Clin Invest. 2023 Mar 15;133(6):e162139. doi: 10.1172/JCI162139. PubMed |
| Fibroblast-expressed LRRC15 is a receptor for SARS-CoV-2 spike and controls antiviral and antifibrotic transcriptional programs. Loo L, Waller MA, Moreno CL, Cole AJ, Stella AO, Pop OT, Jochum AK, Ali OH, Denes CE, Hamoudi Z, Chung F, Aggarwal A, Low JKK, Patel K, Siddiquee R, Kang T, Mathivanan S, Mackay JP, Jochum W, Flatz L, Hesselson D, Turville S, Neely GG. PLoS Biol. 2023 Feb 9;21(2):e3001967. doi: 10.1371/journal.pbio.3001967. eCollection 2023 Feb. PubMed |
| Pharmacological tumor PDL1 depletion with chlorambucil treats ovarian cancer and melanoma: improves antitumor immunity and renders anti-PDL1-resistant tumors anti-PDL1-sensitive through NK cell effects. Bai H, Padron AS, Deng Y, Liao YJ, Murray CJ, Ontiveros C, Kari SJ, Kancharla A, Kornepati AVR, Garcia M, Reyes RM, Gupta HB, Conejo-Garcia JR, Curiel T. J Immunother Cancer. 2023 Feb;11(2):e004871. doi: 10.1136/jitc-2022-004871. PubMed |
| ZBTB12 is a molecular barrier to dedifferentiation in human pluripotent stem cells. Han D, Liu G, Oh Y, Oh S, Yang S, Mandjikian L, Rani N, Almeida MC, Kosik KS, Jang J. Nat Commun. 2023 Feb 9;14(1):632. doi: 10.1038/s41467-023-36178-9. PubMed |
| ERdj5 protects goblet cells from endoplasmic reticulum stress-mediated apoptosis under inflammatory conditions. Jeong H, Hong EH, Ahn JH, Cho J, Jeong JH, Kim CW, Yoon BI, Koo JH, Park YY, Yang YM, Iwawaki T, Vallance BA, Chang SY, Ko HJ. Exp Mol Med. 2023 Feb;55(2):401-412. doi: 10.1038/s12276-023-00945-x. Epub 2023 Feb 9. PubMed |
The PROTECTOR strategy employs dCas orthologs to sterically shield off-target sites from CRISPR/Cas activity.
Sapozhnikov DM, Szyf M.
Sci Rep. 2023 Feb 9;13(1):2280. doi: 10.1038/s41598-023-29332-2.
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| Decoupling peptide binding from T cell receptor recognition with engineered chimeric MHC-I molecules. Papadaki GF, Ani O, Florio TJ, Young MC, Danon JN, Sun Y, Dersh D, Sgourakis NG. Front Immunol. 2023 Jan 25;14:1116906. doi: 10.3389/fimmu.2023.1116906. eCollection 2023. PubMed |
| The NOTCH-RIPK4-IRF6-ELOVL4 Axis Suppresses Squamous Cell Carcinoma. Yan Y, Gauthier MA, Malik A, Fotiadou I, Ostrovski M, Dervovic D, Ghadban L, Tsai R, Gish G, Loganathan SK, Schramek D. Cancers (Basel). 2023 Jan 25;15(3):737. doi: 10.3390/cancers15030737. PubMed |
| Novel Local "Off-the-Shelf" Immunotherapy for the Treatment of Myeloma Bone Disease. Charvatova S, Motais B, Czapla J, Cichon T, Smolarczyk R, Walek Z, Giebel S, Hajek R, Bago JR. Cells. 2023 Jan 30;12(3):448. doi: 10.3390/cells12030448. PubMed |
| Epigenetic Regulation of MAP3K8 in EBV-Associated Gastric Carcinoma. Roy G, Yang T, Liu S, Luo YL, Liu Y, Zhong Q. Int J Mol Sci. 2023 Jan 19;24(3):1964. doi: 10.3390/ijms24031964. PubMed |
| Role of Transcription Factor EB in Mitochondrial Dysfunction of Cisplatin-Induced Acute Kidney Injury. Wang S, Chen Y, Wu H, Li X, Xiao H, Pan Q, Liu HF. Int J Mol Sci. 2023 Feb 3;24(3):3028. doi: 10.3390/ijms24033028. PubMed |
| Targeting the E3 ligase NEDD4 as a novel therapeutic strategy for IGF1 signal pathway-driven gastric cancer. Wang K, Yu Y, Wang W, Jiang Y, Li Y, Jiang X, Qiao Y, Chen L, Zhao X, Liu J, Yang A, Li J, Zhang R. Oncogene. 2023 Mar;42(14):1072-1087. doi: 10.1038/s41388-023-02619-4. Epub 2023 Feb 11. PubMed |
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PubMed
Associated Plasmids |
| Enhancer variants on chromosome 2p14 regulating SPRED2 and ACTR2 act as a signal amplifier to protect against rheumatoid arthritis. Wang NN, Zhang Y, Jiang F, Zhu DL, Di CX, Hu SY, Chen XF, Zhi LQ, Rong Y, Ke X, Duan YY, Dong SS, Yang TL, Yang Z, Guo Y. Am J Hum Genet. 2023 Apr 6;110(4):625-637. doi: 10.1016/j.ajhg.2023.02.012. Epub 2023 Mar 15. PubMed |
| Excessive transcription-replication conflicts are a vulnerability of BRCA1-mutant cancers. Patel PS, Algouneh A, Krishnan R, Reynolds JJ, Nixon KCJ, Hao J, Lee J, Feng Y, Fozil C, Stanic M, Yerlici T, Su P, Soares F, Liedtke E, Prive G, Baider GD, Pujana MA, Mekhail K, He HH, Hakem A, Stewart GS, Hakem R. Nucleic Acids Res. 2023 May 22;51(9):4341-4362. doi: 10.1093/nar/gkad172. PubMed |
| Restoration of mitochondrial function through activation of hypomodified tRNAs with pathogenic mutations associated with mitochondrial diseases. Tomoda E, Nagao A, Shirai Y, Asano K, Suzuki T, Battersby BJ, Suzuki T. Nucleic Acids Res. 2023 Aug 11;51(14):7563-7579. doi: 10.1093/nar/gkad139. PubMed |
| 4E-BP1 counteracts human mesenchymal stem cell senescence via maintaining mitochondrial homeostasis. He Y, Ji Q, Wu Z, Cai Y, Yin J, Zhang Y, Zhang S, Liu X, Zhang W, Liu GH, Wang S, Song M, Qu J. Protein Cell. 2023 Apr 13;14(3):202-216. doi: 10.1093/procel/pwac037. PubMed |
| VE-822 upregulates the deubiquitinase OTUD1 to stabilize FHL1 to inhibit the progression of lung adenocarcinoma. Zhang Q, Li J, Chen Z, Jiang K, Yang K, Huang F, Huang A, Zhang X, Zhang J, Wang H. Cell Oncol (Dordr). 2023 Aug;46(4):1001-1014. doi: 10.1007/s13402-023-00793-x. Epub 2023 Mar 16. PubMed |
| Activation of Hippo Pathway Damages Slit Diaphragm by Deprivation of Ajuba Proteins. Gilhaus K, Cepok C, Kamm D, Surmann B, Nedvetsky PI, Emich J, Sundukova A, Saatkamp K, Nusse H, Klingauf J, Wennmann DO, George B, Krahn MP, Pavenstadt HJ, Vollenbroker BA. J Am Soc Nephrol. 2023 Jun 1;34(6):1039-1055. doi: 10.1681/ASN.0000000000000107. Epub 2023 Mar 16. PubMed |
| Development of SpCas9-expressing bovine mammary epithelial cell lines. Trevarton AJ, Mears ER, Moody J, Lopdell TJ, Chometon TQ, Taylor JA, Wang CJ, Littlejohn MD, Snell RG. In Vitro Cell Dev Biol Anim. 2023 Mar;59(3):163-165. doi: 10.1007/s11626-023-00756-4. Epub 2023 Mar 17. PubMed |
| HDAC3 is critical in tumor development and therapeutic resistance in Kras-mutant non-small cell lung cancer. Eichner LJ, Curtis SD, Brun SN, McGuire CK, Gushterova I, Baumgart JT, Trefts E, Ross DS, Rymoff TJ, Shaw RJ. Sci Adv. 2023 Mar 15;9(11):eadd3243. doi: 10.1126/sciadv.add3243. Epub 2023 Mar 17. PubMed |
| Endogenous but not sensory-driven activity controls migration, morphogenesis and survival of adult-born juxtaglomerular neurons in the mouse olfactory bulb. Li K, Figarella K, Su X, Kovalchuk Y, Gorzolka J, Neher JJ, Mojtahedi N, Casadei N, Hedrich UBS, Garaschuk O. Cell Mol Life Sci. 2023 Mar 18;80(4):98. doi: 10.1007/s00018-023-04753-4. PubMed |
| Honokiol acts as an AMPK complex agonist therapeutic in non-alcoholic fatty liver disease and metabolic syndrome. Tian R, Yang J, Wang X, Liu S, Dong R, Wang Z, Yang Z, Zhang Y, Cai Z, Yang H, Hu Y, She ZG, Li H, Zhou J, Zhang XJ. Chin Med. 2023 Mar 17;18(1):30. doi: 10.1186/s13020-023-00729-5. PubMed |
| Single-cell transcriptomic atlas of mouse cochlear aging. Sun G, Zheng Y, Fu X, Zhang W, Ren J, Ma S, Sun S, He X, Wang Q, Ji Z, Cheng F, Yan K, Liu Z, Belmonte JCI, Qu J, Wang S, Chai R, Liu GH. Protein Cell. 2023 Apr 13;14(3):180-201. doi: 10.1093/procel/pwac058. PubMed |
| The vascular gene Apold1 is dispensable for normal development but controls angiogenesis under pathological conditions. Fan Z, Ardicoglu R, Batavia AA, Rust R, von Ziegler L, Waag R, Zhang J, Desgeorges T, Sturman O, Dang H, Weber R, Roszkowski M, Moor AE, Schwab ME, Germain PL, Bohacek J, De Bock K. Angiogenesis. 2023 Aug;26(3):385-407. doi: 10.1007/s10456-023-09870-z. Epub 2023 Mar 18. PubMed |
| Precise excision of HTLV-1 provirus with a designer-recombinase. Rojo-Romanos T, Karpinski J, Millen S, Beschorner N, Simon F, Paszkowski-Rogacz M, Lansing F, Schneider PM, Sonntag J, Hauber J, Thoma-Kress AK, Buchholz F. Mol Ther. 2023 Jul 5;31(7):2266-2285. doi: 10.1016/j.ymthe.2023.03.014. Epub 2023 Mar 17. PubMed |
| A new method to synthesize multiple gRNA libraries and functional mapping of mammalian H3K4me3 regions. Pan C, Li R, Shui L, Xiao Z, Wang Y, Zhu J, Wu C, Zhang L, Jia J, Zheng M. Nucleic Acids Res. 2023 May 22;51(9):e50. doi: 10.1093/nar/gkad198. PubMed |
| TCF1/LEF1 triggers Wnt-dependent chemokine/cytokine-induced inflammation and cadherin pathways to drive T-ALL cell migration. Zhao P, Sun L, Zhao C. Biochem Biophys Rep. 2023 Mar 12;34:101457. doi: 10.1016/j.bbrep.2023.101457. eCollection 2023 Jul. PubMed |
| Purinergic GPCR-integrin interactions drive pancreatic cancer cell invasion. Tomas Bort E, Joseph MD, Wang Q, Carter EP, Roth NJ, Gibson J, Samadi A, Kocher HM, Simoncelli S, McCormick PJ, Grose RP. Elife. 2023 Mar 21;12:e86971. doi: 10.7554/eLife.86971. PubMed |
| Massively parallel characterization of transcriptional regulatory elements in three diverse human cell types. Agarwal V, Inoue F, Schubach M, Martin BK, Dash PM, Zhang Z, Sohota A, Noble WS, Yardimci GG, Kircher M, Shendure J, Ahituv N. bioRxiv. 2023 Mar 6:2023.03.05.531189. doi: 10.1101/2023.03.05.531189. Preprint. PubMed |
| Dynamics of Chromatin Accessibility During Hematopoietic Stem Cell Differentiation Into Progressively Lineage-Committed Progeny. Martin EW, Rodriguez Y Baena A, Reggiardo RE, Worthington AK, Mattingly CS, Poscablo DM, Krietsch J, McManus MT, Carpenter S, Kim DH, Forsberg EC. Stem Cells. 2023 May 15;41(5):520-539. doi: 10.1093/stmcls/sxad022. PubMed |
| Regulatory and coding sequences of TRNP1 co-evolve with brain size and cortical folding in mammals. Kliesmete Z, Wange LE, Vieth B, Esgleas M, Radmer J, Hulsmann M, Geuder J, Richter D, Ohnuki M, Gotz M, Hellmann I, Enard W. Elife. 2023 Mar 22;12:e83593. doi: 10.7554/eLife.83593. PubMed |
| RBFOX2 modulates a metastatic signature of alternative splicing in pancreatic cancer. Jbara A, Lin KT, Stossel C, Siegfried Z, Shqerat H, Amar-Schwartz A, Elyada E, Mogilevsky M, Raitses-Gurevich M, Johnson JL, Yaron TM, Ovadia O, Jang GH, Danan-Gotthold M, Cantley LC, Levanon EY, Gallinger S, Krainer AR, Golan T, Karni R. Nature. 2023 May;617(7959):147-153. doi: 10.1038/s41586-023-05820-3. Epub 2023 Mar 22. PubMed |
| Response to "Letter to the Editor From Penning and Deltefsen "5-hydroxyeicosatetraenoic Acid Controls Androgen Reduction in Diverse Types of Human Epithelial Cells". Hardaway AL, Goodarzi M, Berk M, Li J, Chung YM, Sharifi N. Endocrinology. 2023 Mar 13;164(5):bqad053. doi: 10.1210/endocr/bqad053. PubMed |
| LncRNA HHIP-AS1 suppresses lung squamous cell carcinoma by stabilizing HHIP mRNA. Hu Z, Liu Y, Tang J, Luo R, Qin J, Mo Z, Xie J, Jiang X, Wei S, Lin C. Life Sci. 2023 May 15;321:121578. doi: 10.1016/j.lfs.2023.121578. Epub 2023 Mar 21. PubMed |
| Thymidine nucleotide metabolism controls human telomere length. Mannherz W, Agarwal S. Nat Genet. 2023 Apr;55(4):568-580. doi: 10.1038/s41588-023-01339-5. Epub 2023 Mar 23. PubMed |
| Arginine shortage induces replication stress and confers genotoxic resistance by inhibiting histone H4 translation and promoting PCNA ubiquitination. Wang YC, Kelso AA, Karamafrooz A, Chen YH, Chen WK, Cheng CT, Qi Y, Gu L, Malkas L, Taglialatela A, Kung HJ, Moldovan GL, Ciccia A, Stark JM, Ann DK. Cell Rep. 2023 Apr 25;42(4):112296. doi: 10.1016/j.celrep.2023.112296. Epub 2023 Mar 23. PubMed |
| Transcriptional activation of endogenous Oct4 via the CRISPR/dCas9 activator ameliorates Hutchinson-Gilford progeria syndrome in mice. Kim J, Hwang Y, Kim S, Chang Y, Kim Y, Kwon Y, Kim J. Aging Cell. 2023 Jun;22(6):e13825. doi: 10.1111/acel.13825. Epub 2023 Mar 25. PubMed |
| An actin filament branching surveillance system regulates cell cycle progression, cytokinesis and primary ciliogenesis. Cao M, Zou X, Li C, Lin Z, Wang N, Zou Z, Ye Y, Seemann J, Levine B, Tang Z, Zhong Q. Nat Commun. 2023 Mar 27;14(1):1687. doi: 10.1038/s41467-023-37340-z. PubMed |
| Disruption of the MYC Superenhancer Complex by Dual Targeting of FLT3 and LSD1 in Acute Myeloid Leukemia. Yashar WM, Curtiss BM, Coleman DJ, VanCampen J, Kong G, Macaraeg J, Estabrook J, Demir E, Long N, Bottomly D, McWeeney SK, Tyner JW, Druker BJ, Maxson JE, Braun TP. Mol Cancer Res. 2023 Jul 5;21(7):631-647. doi: 10.1158/1541-7786.MCR-22-0745. PubMed |
| Inactivation of SARS-CoV-2 on Surfaces by Cold-Plasma-Generated Reactive Species. Thomas SV, Dienger-Stambaugh K, Jordan M, Wang Y, Hammonds J, Spearman P, Shi D. Bioengineering (Basel). 2023 Feb 21;10(3):280. doi: 10.3390/bioengineering10030280. PubMed |
| Importance of ACE2 for SARS-CoV-2 Infection of Kidney Cells. Kroll MK, Schloer S, Candan P, Korthals N, Wenzel C, Ihle H, Gilhaus K, Liedtke KR, Schofbanker M, Surmann B, Schroter R, Neugebauer U, Mall G, Oswald S, Ludwig S, Rescher U, Vollenbroker B, Ciarimboli G. Biomolecules. 2023 Mar 3;13(3):472. doi: 10.3390/biom13030472. PubMed |
| MYCN Amplification, along with Wild-Type RB1 Expression, Enhances CDK4/6 Inhibitors' Efficacy in Neuroblastoma Cells. De Rosa P, Severi F, Zadran SK, Russo M, Aloisi S, Rigamonti A, Capranico G, Milazzo G, Perini G. Int J Mol Sci. 2023 Mar 12;24(6):5408. doi: 10.3390/ijms24065408. PubMed |
CRISPR screens identify gene targets at breast cancer risk loci.
Tuano NK, Beesley J, Manning M, Shi W, Perlaza-Jimenez L, Malaver-Ortega LF, Paynter JM, Black D, Civitarese A, McCue K, Hatzipantelis A, Hillman K, Kaufmann S, Sivakumaran H, Polo JM, Reddel RR, Band V, French JD, Edwards SL, Powell DR, Chenevix-Trench G, Rosenbluh J.
Genome Biol. 2023 Mar 29;24(1):59. doi: 10.1186/s13059-023-02898-w.
PubMed
Associated Plasmids |
| Long noncoding RNA Malat1 inhibits Tead3-Nfatc1-mediated osteoclastogenesis to suppress osteoporosis and bone metastasis. Zhao Y, Teng H, Deng Y, Sheldon M, Martinez C, Zhang J, Tian A, Sun Y, Nakagawa S, Yao F, Wang H, Ma L. Res Sq. 2023 Mar 20:rs.3.rs-2405644. doi: 10.21203/rs.3.rs-2405644/v1. Preprint. PubMed |
| Genomic transcription factor binding site selection is edited by the chromatin remodeling factor CHD4. Takaku M, Saotome M, Poduval D, Grimm S, Nagornyuk A, Gunarathna S, Shimbo T, Wade P. Res Sq. 2023 Mar 15:rs.3.rs-2587918. doi: 10.21203/rs.3.rs-2587918/v1. Preprint. PubMed |
| Role of GD2 and its biosynthetic enzyme GD3 synthase in prostate cancer tumorigenesis. Bhat AM, Mohapatra BC, Luan H, Mushtaq I, Chakraborty S, Dutta S, Stock MD, Meza JL, Lele SM, Lin MF, Cook LM, Corey E, Morrissey C, Coulter DW, Rowley J, Datta K, Band V, Band H. bioRxiv. 2023 Apr 22:2023.03.18.533299. doi: 10.1101/2023.03.18.533299. Preprint. PubMed |
| Guide-specific loss of efficiency and off-target reduction with Cas9 variants. Zhang L, He W, Fu R, Xu H. bioRxiv. 2023 Mar 16:2023.03.16.532856. doi: 10.1101/2023.03.16.532856. Preprint. PubMed |
| Curved adhesions mediate cell attachment to soft matrix fibres in 3D. Zhang W, Lu CH, Nakamoto ML, Tsai CT, Roy AR, Lee CE, Yang Y, Jahed Z, Li X, Cui B. bioRxiv. 2023 Mar 19:2023.03.16.532975. doi: 10.1101/2023.03.16.532975. Preprint. PubMed |
| RTF2 controls replication repriming and ribonucleotide excision at the replisome. Conti BA, Ruiz PD, Broton C, Blobel NJ, Kottemann MC, Sridhar S, Lach FP, Wiley T, Sasi NK, Carroll T, Smogorzewska A. bioRxiv. 2023 Mar 13:2023.03.13.532415. doi: 10.1101/2023.03.13.532415. Preprint. PubMed |
| Activity-dependent subcellular compartmentalization of dendritic mitochondria structure in CA1 pyramidal neurons. Virga DM, Hamilton S, Osei B, Morgan A, Zamponi E, Park NJ, Hewitt VL, Zhang D, Gonzalez KC, Bloss E, Polleux F, Lewis TL. bioRxiv. 2023 Mar 26:2023.03.25.534233. doi: 10.1101/2023.03.25.534233. Preprint. PubMed |
| Shared gene targets of the ATF4 and p53 transcriptional networks. Baniulyte G, Durham SA, Merchant LE, Sammons MA. bioRxiv. 2023 Jun 5:2023.03.15.532778. doi: 10.1101/2023.03.15.532778. Preprint. PubMed |
| Exploring SARS-CoV-2 and Plasmodium falciparum coinfection in human erythrocytes. Lopez-Farfan D, Irigoyen N, Gomez-Diaz E. Front Immunol. 2023 Mar 13;14:1120298. doi: 10.3389/fimmu.2023.1120298. eCollection 2023. PubMed |
Overexpression screen of chromosome 21 genes reveals modulators of Sonic hedgehog signaling relevant to Down syndrome.
Moyer AJ, Fernandez FX, Li Y, Klinedinst DK, Florea LD, Kazuki Y, Oshimura M, Reeves RH.
Dis Model Mech. 2023 Apr 1;16(4):dmm049712. doi: 10.1242/dmm.049712. Epub 2023 Apr 13.
PubMed
Associated Plasmids |
Hominoid SVA-lncRNA AK057321 targets human-specific SVA retrotransposons in SCN8A and CDK5RAP2 to initiate neuronal maturation.
Nadler MJS, Chang W, Ozkaynak E, Huo Y, Nong Y, Boillot M, Johnson M, Moreno A, Matthew P Anderson.
Commun Biol. 2023 Mar 30;6(1):347. doi: 10.1038/s42003-023-04683-8.
PubMed
Associated Plasmids |
| RRM2 and CDC6 are novel effectors of XBP1-mediated endocrine resistance and predictive markers of tamoxifen sensitivity. Barua D, Sultana A, Islam MN, Cox F, Gupta A, Gupta S. BMC Cancer. 2023 Mar 30;23(1):288. doi: 10.1186/s12885-023-10745-1. PubMed |
| Protocol for performing pooled CRISPR-Cas9 loss-of-function screens. Mathiowetz AJ, Roberts MA, Morgens DW, Olzmann JA, Li Z. STAR Protoc. 2023 Mar 30;4(2):102201. doi: 10.1016/j.xpro.2023.102201. PubMed |
| Evolution of Immune Evasion and Host Range Expansion by the SARS-CoV-2 B.1.1.529 (Omicron) Variant. Ren W, Zhang Y, Rao J, Wang Z, Lan J, Liu K, Zhang X, Hu X, Yang C, Zhong G, Zhang R, Wang X, Shan C, Ding Q. mBio. 2023 Apr 25;14(2):e0041623. doi: 10.1128/mbio.00416-23. Epub 2023 Apr 3. PubMed |
| Regulation of human trophoblast gene expression by endogenous retroviruses. Frost JM, Amante SM, Okae H, Jones EM, Ashley B, Lewis RM, Cleal JK, Caley MP, Arima T, Maffucci T, Branco MR. Nat Struct Mol Biol. 2023 Apr;30(4):527-538. doi: 10.1038/s41594-023-00960-6. Epub 2023 Apr 3. PubMed |
| Downregulation of AC092894.1 promotes oxaliplatin resistance in colorectal cancer via the USP3/AR/RASGRP3 axis. Zheng Z, Wu M, Li H, Xu W, Yang M, Pan K, Ni Y, Jiang T, Zheng H, Jin X, Zhang Y, Ding L, Fu J. BMC Med. 2023 Apr 3;21(1):132. doi: 10.1186/s12916-023-02826-6. PubMed |
| Lovastatin inhibits erythroleukemia progression through KLF2-mediated suppression of MAPK/ERK signaling. Gao J, Hu J, Yu F, Wang C, Sheng D, Liu W, Hu A, Yu K, Xiao X, Kuang Y, Zacksenhaus E, Gajendran B, Ben-David Y. BMC Cancer. 2023 Apr 4;23(1):306. doi: 10.1186/s12885-023-10742-4. PubMed |
| AGS3 antagonizes LGN to balance oriented cell divisions and cell fate choices in mammalian epidermis. Descovich CP, Lough KJ, Jena A, Wu JJ, Yom J, Spitzer DC, Uppalapati M, Kedziora KM, Williams SE. Elife. 2023 Apr 5;12:e80403. doi: 10.7554/eLife.80403. PubMed |
| A stress-induced cilium-to-PML-NB route drives senescence initiation. Ma X, Zhang Y, Zhang Y, Zhang X, Huang Y, He K, Chen C, Hao J, Zhao D, LeBrasseur NK, Kirkland JL, Chini EN, Wei Q, Ling K, Hu J. Nat Commun. 2023 Apr 3;14(1):1840. doi: 10.1038/s41467-023-37362-7. PubMed |
| Identification of Ndfip1 as a novel negative regulator for spatial memory formation associated with increased ubiquitination of Beclin 1 and PTEN. Hsu WL, Ma YL, Chen YC, Liu YC, Cheng KM, Lee EHY. PLoS One. 2023 Apr 6;18(4):e0283908. doi: 10.1371/journal.pone.0283908. eCollection 2023. PubMed |
| Targeting HDAC11 activity by FT895 restricts EV71 replication. Xie H, Yang E, Wang C, Peng C, Ji L. Virus Res. 2023 Jun;330:199108. doi: 10.1016/j.virusres.2023.199108. Epub 2023 Apr 15. PubMed |
| Carbon nanotube recognition by human Siglec-14 provokes inflammation. Yamaguchi SI, Xie Q, Ito F, Terao K, Kato Y, Kuroiwa M, Omori S, Taniura H, Kinoshita K, Takahashi T, Toyokuni S, Kasahara K, Nakayama M. Nat Nanotechnol. 2023 Jun;18(6):628-636. doi: 10.1038/s41565-023-01363-w. Epub 2023 Apr 6. PubMed |
| Optimized whole-genome CRISPR interference screens identify ARID1A-dependent growth regulators in human induced pluripotent stem cells. Usluer S, Hallast P, Crepaldi L, Zhou Y, Urgo K, Dincer C, Su J, Noell G, Alasoo K, El Garwany O, Gerety SS, Newman B, Dovey OM, Parts L. Stem Cell Reports. 2023 May 9;18(5):1061-1074. doi: 10.1016/j.stemcr.2023.03.008. Epub 2023 Apr 6. PubMed |
| Suramin binds and inhibits infection of SARS-CoV-2 through both spike protein-heparan sulfate and ACE2 receptor interactions. Kwon PS, Xu S, Oh H, Kwon SJ, Rodrigues AL, Feroz M, Fraser K, He P, Zhang F, Hong JJ, Linhardt RJ, Dordick JS. Commun Biol. 2023 Apr 8;6(1):387. doi: 10.1038/s42003-023-04789-z. PubMed |
| Combined therapy with methotrexate nanoconjugate and dendritic cells with downregulated IL-10R expression modulates the tumor microenvironment and enhances the systemic anti-tumor immune response in MC38 murine colon carcinoma. Szczygiel A, Wegierek-Ciura K, Wroblewska A, Mierzejewska J, Rossowska J, Szermer-Olearnik B, Switalska M, Anger-Gora N, Goszczynski TM, Pajtasz-Piasecka E. Front Immunol. 2023 Mar 23;14:1155377. doi: 10.3389/fimmu.2023.1155377. eCollection 2023. PubMed |
| TNF-NFkB-p53 axis restricts in vivo survival of hPSC-derived dopamine neuron. Kim TW, Koo SY, Riessland M, Cho H, Chaudhry F, Kolisnyk B, Russo MV, Saurat N, Mehta S, Garippa R, Betel D, Studer L. bioRxiv. 2023 Mar 31:2023.03.29.534819. doi: 10.1101/2023.03.29.534819. Preprint. PubMed |
| Asparagine starvation suppresses histone demethylation through iron depletion. Jiang J, Srivastava S, Liu S, Seim G, Claude R, Zhong M, Cao S, Dave U, Kapur R, Mosley AL, Zhang C, Wan J, Fan J, Zhang J. iScience. 2023 Mar 16;26(4):106425. doi: 10.1016/j.isci.2023.106425. eCollection 2023 Apr 21. PubMed |
| Targeted therapy for cisplatin-resistant lung cancer via aptamer-guided nano-zinc carriers containing USP14 siRNA. Zhao X, Wu X, Wang H, Lai S, Wang J. MedComm (2020). 2023 Apr 6;4(2):e237. doi: 10.1002/mco2.237. eCollection 2023 Apr. PubMed |
| Long Noncoding RNA AROD Inhibits Host Antiviral Innate Immunity via the miR-324-5p-CUEDC2 Axis. Zhang Z, Yu T, Li H, Du L, Jin Z, Peng X, Yan Y, Zhou J, Gu J. Microbiol Spectr. 2023 Jun 15;11(3):e0420622. doi: 10.1128/spectrum.04206-22. Epub 2023 Apr 10. PubMed |
| Botulinum neurotoxin A modulates the axonal release of pathological tau in hippocampal neurons. Panzi C, Surana S, De La-Rocque S, Moretto E, Lazo OM, Schiavo G. Toxicon. 2023 Jun 1;228:107110. doi: 10.1016/j.toxicon.2023.107110. Epub 2023 Apr 8. PubMed |
| Proteomic analysis reveals microvesicles containing NAMPT as mediators of radioresistance in glioma. Panizza E, Regalado BD, Wang F, Nakano I, Vacanti NM, Cerione RA, Antonyak MA. Life Sci Alliance. 2023 Apr 10;6(6):e202201680. doi: 10.26508/lsa.202201680. Print 2023 Jun. PubMed |
| A kinesin-based approach for inducing chromosome-specific mis-segregation in human cells. Truong MA, Cane-Gasull P, de Vries SG, Nijenhuis W, Wardenaar R, Kapitein LC, Foijer F, Lens SM. EMBO J. 2023 May 15;42(10):e111559. doi: 10.15252/embj.2022111559. Epub 2023 Apr 11. PubMed |
| High-throughput screening of spike variants uncovers the key residues that alter the affinity and antigenicity of SARS-CoV-2. Luo Y, Liu S, Xue J, Yang Y, Zhao J, Sun Y, Wang B, Yin S, Li J, Xia Y, Ge F, Dong J, Guo L, Ye B, Huang W, Wang Y, Xi JJ. Cell Discov. 2023 Apr 11;9(1):40. doi: 10.1038/s41421-023-00534-2. PubMed |
| A CRISPR/Cas9-Based Assay for High-Throughput Studies of Cancer-Induced Innervation. Galappaththi SL, Katz B, Howze PH 4th, Hoover G, Grelet S. Cancers (Basel). 2023 Mar 29;15(7):2026. doi: 10.3390/cancers15072026. PubMed |
| The circadian protein BMAL1 supports endothelial cell cycle during angiogenesis. Astone M, Oberkersch RE, Tosi G, Biscontin A, Santoro MM. Cardiovasc Res. 2023 Aug 19;119(10):1952-1968. doi: 10.1093/cvr/cvad057. PubMed |
| CAPRIN1 Is Required for Control of Viral Replication Complexes by Interferon Gamma. Kurhade C, Kang S, Biering SB, Hwang S, Randall G. mBio. 2023 Jun 27;14(3):e0017223. doi: 10.1128/mbio.00172-23. Epub 2023 Apr 13. PubMed |
Nucleocytoplasmic transport of active HER2 causes fractional escape from the DCIS-like state.
Wang L, Paudel BB, McKnight RA, Janes KA.
Nat Commun. 2023 Apr 13;14(1):2110. doi: 10.1038/s41467-023-37914-x.
PubMed
Associated Plasmids |
| Hepatocyte differentiation from mouse liver ductal organoids by transducing 4 liver-specific transcription factors. Tomofuji K, Kondo J, Onuma K, Coppo R, Horie H, Oyama K, Miyoshi E, Fukumitsu K, Ishii T, Hatano E, Inoue M. Hepatol Commun. 2023 Apr 14;7(5):e0134. doi: 10.1097/HC9.0000000000000134. eCollection 2023 May 1. PubMed |
| MALT1 paracaspase is overexpressed in hepatocellular carcinoma and promotes cancer cell survival and growth. Kurden-Pekmezci A, Cakiroglu E, Eris S, Mazi FA, Coskun-Deniz OS, Dalgic E, Oz O, Senturk S. Life Sci. 2023 Jun 15;323:121690. doi: 10.1016/j.lfs.2023.121690. Epub 2023 Apr 13. PubMed |
| In mitosis integrins reduce adhesion to extracellular matrix and strengthen adhesion to adjacent cells. Huber M, Casares-Arias J, Fassler R, Muller DJ, Strohmeyer N. Nat Commun. 2023 Apr 14;14(1):2143. doi: 10.1038/s41467-023-37760-x. PubMed |
| CD95/Fas ligand mRNA is toxic to cells through more than one mechanism. Haluck-Kangas A, Fink M, Bartom ET, Peter ME. Mol Biomed. 2023 Apr 15;4(1):11. doi: 10.1186/s43556-023-00119-1. PubMed |
| PHLPP1 regulates PINK1-parkin signalling and life span. Chandra K, Swathi M, Keerthana B, Gopan S, Ghantasala JP, Joshi MB, Thondamal M, Parsa KVL. Biochim Biophys Acta Mol Basis Dis. 2023 Aug;1869(6):166718. doi: 10.1016/j.bbadis.2023.166718. Epub 2023 Apr 13. PubMed |
| TFCP2 is a transcriptional regulator of heparan sulfate assembly and melanoma cell growth. Basu A, Champagne RN, Patel NG, Nicholson ED, Weiss RJ. J Biol Chem. 2023 Jun;299(6):104713. doi: 10.1016/j.jbc.2023.104713. Epub 2023 Apr 13. PubMed |
| Trim-Away ubiquitinates and degrades lysine-less and N-terminally acetylated substrates. Kiss L, Rhinesmith T, Luptak J, Dickson CF, Weidenhausen J, Smyly S, Yang JC, Maslen SL, Sinning I, Neuhaus D, Clift D, James LC. Nat Commun. 2023 Apr 15;14(1):2160. doi: 10.1038/s41467-023-37504-x. PubMed |
| Simultaneous engineering of natural killer cells for CAR transgenesis and CRISPR-Cas9 knockout using retroviral particles. Jo DH, Kaczmarek S, Shin O, Wang L, Cowan J, McComb S, Lee SH. Mol Ther Methods Clin Dev. 2023 Mar 15;29:173-184. doi: 10.1016/j.omtm.2023.03.006. eCollection 2023 Jun 8. PubMed |
The viral packaging motor potentiates Kaposi's sarcoma-associated herpesvirus gene expression late in infection.
McCollum CO, Didychuk AL, Liu D, Murray-Nerger LA, Cristea IM, Glaunsinger BA.
PLoS Pathog. 2023 Apr 17;19(4):e1011163. doi: 10.1371/journal.ppat.1011163. eCollection 2023 Apr.
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| Septin11 promotes hepatocellular carcinoma cell motility by activating RhoA to regulate cytoskeleton and cell adhesion. Fu L, Wang X, Yang Y, Chen M, Kuerban A, Liu H, Dong Y, Cai Q, Ma M, Wu X. Cell Death Dis. 2023 Apr 20;14(4):280. doi: 10.1038/s41419-023-05726-y. PubMed |
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| The transcriptional co-activator Yap1 promotes adult hippocampal neural stem cell activation. Fan W, Jurado-Arjona J, Alanis-Lobato G, Peron S, Berger C, Andrade-Navarro MA, Falk S, Berninger B. EMBO J. 2023 Jun 1;42(11):e110384. doi: 10.15252/embj.2021110384. Epub 2023 Apr 21. PubMed |
| RNA binding protein SYNCRIP maintains proteostasis and self-renewal of hematopoietic stem and progenitor cells. Herrejon Chavez F, Luo H, Cifani P, Pine A, Chu KL, Joshi S, Barin E, Schurer A, Chan M, Chang K, Han GYQ, Pierson AJ, Xiao M, Yang X, Kuehm LM, Hong Y, Nguyen DTT, Chiosis G, Kentsis A, Leslie C, Vu LP, Kharas MG. Nat Commun. 2023 Apr 21;14(1):2290. doi: 10.1038/s41467-023-38001-x. PubMed |
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Prediction of efficiencies for diverse prime editing systems in multiple cell types.
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| Ring finger protein 12 activates AKT signalling to promote the progression of liver cancer by interacting with EGFR. Yu C, Rao D, Wang T, Sheng J, Lv E, Zhang L, Lu X, Yu J, Liang H, Song J, Huang W. J Cell Mol Med. 2023 Jun;27(11):1523-1538. doi: 10.1111/jcmm.17757. Epub 2023 May 2. PubMed |
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| Therapeutic blocking of VEGF binding to neuropilin-2 diminishes PD-L1 expression to activate antitumor immunity in prostate cancer. Wang M, Wisniewski CA, Xiong C, Chhoy P, Goel HL, Kumar A, Zhu LJ, Li R, St Louis PA, Ferreira LM, Pakula H, Xu Z, Loda M, Jiang Z, Brehm MA, Mercurio AM. Sci Transl Med. 2023 May 3;15(694):eade5855. doi: 10.1126/scitranslmed.ade5855. Epub 2023 May 3. PubMed |
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Discovery of target genes and pathways at GWAS loci by pooled single-cell CRISPR screens.
Morris JA, Caragine C, Daniloski Z, Domingo J, Barry T, Lu L, Davis K, Ziosi M, Glinos DA, Hao S, Mimitou EP, Smibert P, Roeder K, Katsevich E, Lappalainen T, Sanjana NE.
Science. 2023 May 19;380(6646):eadh7699. doi: 10.1126/science.adh7699. Epub 2023 May 19.
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| CyclosporinA Derivative as Therapeutic Candidate for Alport Syndrome by Inducing Mutant Type IV Collagen Secretion. Kuwazuru J, Suico MA, Omachi K, Kojima H, Kamura M, Kaseda S, Kawahara T, Hitora Y, Kato H, Tsukamoto S, Wada M, Asano T, Kotani S, Nakajima M, Misumi S, Sannomiya Y, Horizono J, Koyama Y, Owaki A, Shuto T, Kai H. Kidney360. 2023 Jul 1;4(7):909-917. doi: 10.34067/KID.0000000000000134. Epub 2023 May 5. PubMed |
| Pteropine orthoreoviruses use cell surface heparan sulphate as an attachment receptor. Tan CW, Gamage AM, Yap WC, Wei Tang LJ, Sun Y, Yang XL, Pyke A, Chua KB, Wang LF. Emerg Microbes Infect. 2023 Dec;12(1):2208683. doi: 10.1080/22221751.2023.2208683. PubMed |
| CpG dinucleotide enrichment in the influenza A virus genome as a live attenuated vaccine development strategy. Sharp CP, Thompson BH, Nash TJ, Diebold O, Pinto RM, Thorley L, Lin YT, Sives S, Wise H, Clohisey Hendry S, Grey F, Vervelde L, Simmonds P, Digard P, Gaunt ER. PLoS Pathog. 2023 May 5;19(5):e1011357. doi: 10.1371/journal.ppat.1011357. eCollection 2023 May. PubMed |
| XRN2 suppresses aberrant entry of tRNA trailers into argonaute in humans and Arabidopsis. Wilson B, Su Z, Kumar P, Dutta A. PLoS Genet. 2023 May 5;19(5):e1010755. doi: 10.1371/journal.pgen.1010755. eCollection 2023 May. PubMed |
| The adapter protein FADD provides an alternate pathway for entry into the cell cycle by regulating APC/C-Cdh1 E3 ubiquitin ligase activity. Awadia S, Sitto M, Ram S, Ji W, Liu Y, Damani R, Ray D, Lawrence TS, Galban CJ, Cappell SD, Rehemtulla A. J Biol Chem. 2023 Jun;299(6):104786. doi: 10.1016/j.jbc.2023.104786. Epub 2023 May 4. PubMed |
| Methionine consumption by cancer cells drives a progressive upregulation of PD-1 expression in CD4 T cells. Pandit M, Kil YS, Ahn JH, Pokhrel RH, Gu Y, Mishra S, Han Y, Ouh YT, Kang B, Jeong MS, Kim JO, Nam JW, Ko HJ, Chang JH. Nat Commun. 2023 May 5;14(1):2593. doi: 10.1038/s41467-023-38316-9. PubMed |
| Piezo1 opposes age-associated cortical bone loss. Li X, Zhang C, Bowman HH, Stambough JB, Stronach BM, Mears SC, Barnes LC, Ambrogini E, Xiong J. Aging Cell. 2023 Jun;22(6):e13846. doi: 10.1111/acel.13846. Epub 2023 May 5. PubMed |
| Mitochondrial citrate metabolism and efflux regulate BeWo differentiation. Mahr RM, Jena S, Nashif SK, Nelson AB, Rauckhorst AJ, Rome FI, Sheldon RD, Hughey CC, Puchalska P, Gearhart MD, Taylor EB, Crawford PA, Wernimont SA. Sci Rep. 2023 May 6;13(1):7387. doi: 10.1038/s41598-023-34435-x. PubMed |
| HER2 chimeric antigen receptor T cell immunotherapy is an effective treatment for diffuse intrinsic pontine glioma. Wang SS, Davenport AJ, Iliopoulos M, Hughes-Parry HE, Watson KA, Arcucci V, Mulazzani M, Eisenstat DD, Hansford JR, Cross RS, Jenkins MR. Neurooncol Adv. 2023 May 4;5(1):vdad024. doi: 10.1093/noajnl/vdad024. eCollection 2023 Jan-Dec. PubMed |
| Anticancer effect of involucrasin A on colorectal cancer cells by modulating the Akt/MDM2/p53 pathway. Wei C, Du J, Shen Y, Wang Z, Lin Q, Chen J, Zhang F, Lin W, Wang Z, Yang Z, Ma W. Oncol Lett. 2023 Apr 12;25(6):218. doi: 10.3892/ol.2023.13804. eCollection 2023 Jun. PubMed |
| Syngeneic mouse model of human HER2+ metastatic breast cancer for the evaluation of trastuzumab emtansine combined with oncolytic rhabdovirus. Taha Z, Crupi MJF, Alluqmani N, Fareez F, Ng K, Sobh J, Lee E, Chen A, Thomson M, Spinelli MM, Ilkow CS, Bell JC, Arulanandam R, Diallo JS. Front Immunol. 2023 Apr 19;14:1181014. doi: 10.3389/fimmu.2023.1181014. eCollection 2023. PubMed |
| ZFP92, a KRAB domain zinc finger protein enriched in pancreatic islets, binds to B1/Alu SINE transposable elements and regulates retroelements and genes. Osipovich AB, Dudek KD, Trinh LT, Kim LH, Shrestha S, Cartailler JP, Magnuson MA. PLoS Genet. 2023 May 8;19(5):e1010729. doi: 10.1371/journal.pgen.1010729. eCollection 2023 May. PubMed |
| Generalized Strategy for Engineering Mammalian Cell-Compatible RNA-Based Biosensors from Random Sequence Libraries. Allchin ER, Rosch JC, Stoneman AD, Kim H, Lippmann ES. ACS Sens. 2023 May 26;8(5):2079-2086. doi: 10.1021/acssensors.3c00388. Epub 2023 May 8. PubMed |
| ptARgenOM-A Flexible Vector For CRISPR/CAS9 Nonviral Delivery. Radoua A, Pernon B, Pernet N, Jean C, Elmallah M, Guerrache A, Constantinescu AA, Hadj Hamou S, Devy J, Micheau O. Small Methods. 2023 Jul;7(7):e2300069. doi: 10.1002/smtd.202300069. Epub 2023 May 8. PubMed |
| Local Monomer Levels and Established Filaments Potentiate Non-Muscle Myosin 2 Assembly. Quintanilla MA, Patel H, Wu H, Sochacki KA, Akamatsu M, Rotty JD, Korobova F, Bear JE, Taraska JW, Oakes PW, Beach JR. bioRxiv. 2023 Apr 27:2023.04.26.538303. doi: 10.1101/2023.04.26.538303. Preprint. PubMed |
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| Independent control over cell patterning and adhesion on hydrogel substrates for tissue interface mechanobiology. Prahl LS, Porter CM, Liu J, Viola JM, Hughes AJ. iScience. 2023 Apr 11;26(5):106657. doi: 10.1016/j.isci.2023.106657. eCollection 2023 May 19. PubMed |
| Promotive Effect of FBXO32 on the Odontoblastic Differentiation of Human Dental Pulp Stem Cells. Xu K, Liu Q, Huang W, Chu Y, Fan W, Liu J, He Y, Huang F. Int J Mol Sci. 2023 Apr 22;24(9):7708. doi: 10.3390/ijms24097708. PubMed |
| Extracellular Tau Oligomers Damage the Axon Initial Segment. Best MN, Lim Y, Ferenc NN, Kim N, Min L, Wang DB, Sharifi K, Wasserman AE, McTavish SA, Siller KH, Jones MK, Jenkins PM, Mandell JW, Bloom GS. J Alzheimers Dis. 2023;93(4):1425-1441. doi: 10.3233/JAD-221284. PubMed |
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| Enhanced sensitivity of neutralizing antibody detection for different AAV serotypes using HeLa cells with overexpressed AAVR. Zheng Z, Ye J, Leng M, Gan C, Tang N, Li W, Valencia CA, Dong B, Chow HY. Front Pharmacol. 2023 Apr 27;14:1188290. doi: 10.3389/fphar.2023.1188290. eCollection 2023. PubMed |
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| RagD auto-activating mutations impair MiT/TFE activity in kidney tubulopathy and cardiomyopathy syndrome. Sambri I, Ferniani M, Campostrini G, Testa M, Meraviglia V, de Araujo MEG, Dokladal L, Vilardo C, Monfregola J, Zampelli N, Vecchio Blanco FD, Torella A, Ruosi C, Fecarotta S, Parenti G, Staiano L, Bellin M, Huber LA, De Virgilio C, Trepiccione F, Nigro V, Ballabio A. Nat Commun. 2023 May 15;14(1):2775. doi: 10.1038/s41467-023-38428-2. PubMed |
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| FLI1 Regulates Histamine Decarboxylase Expression to Control Inflammation Signaling and Leukemia Progression. Hu J, Gao J, Wang C, Liu W, Hu A, Xiao X, Kuang Y, Yu K, Gajendran B, Zacksenhaus E, Pan W, Ben-David Y. J Inflamm Res. 2023 May 10;16:2007-2020. doi: 10.2147/JIR.S401566. eCollection 2023. PubMed |
| Ex vivo factor VIII-modified proliferating human hepatocytes therapy for haemophilia A. Zhang K, Wu N, Cen J, Li J, Wang Z, Xia Q, Hui L. Cell Prolif. 2023 May;56(5):e13467. doi: 10.1111/cpr.13467. Epub 2023 May 17. PubMed |
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TMEM106B is a receptor mediating ACE2-independent SARS-CoV-2 cell entry.
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| Co-targeting autophagy and NRF2 signaling triggers mitochondrial superoxide to sensitize oral cancer stem cells for cisplatin-induced apoptosis. Praharaj PP, Singh A, Patra S, Bhutia SK. Free Radic Biol Med. 2023 Jul 7;207:72-88. doi: 10.1016/j.freeradbiomed.2023.07.008. PubMed |
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A positively tuned voltage indicator for extended electrical recordings in the brain.
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| Combinatorial targeting of a specific EMT/MET network by macroH2A variants safeguards mesenchymal identity. Valakos D, Klagkou E, Kokkalis A, Polyzos A, Kyrilis FL, Banos A, Vatsellas G, Pliatska M, Ford E, Stravopodis DJ, Thanos D. PLoS One. 2023 Jul 11;18(7):e0288005. doi: 10.1371/journal.pone.0288005. eCollection 2023. PubMed |
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| SARS-CoV-2 main protease cleaves MAGED2 to antagonize host antiviral defense. Ju X, Wang Z, Wang P, Ren W, Yu Y, Yu Y, Yuan B, Song J, Zhang X, Zhang Y, Xu C, Tian B, Shi Y, Zhang R, Ding Q. mBio. 2023 Aug 31;14(4):e0137323. doi: 10.1128/mbio.01373-23. Epub 2023 Jul 13. PubMed |
Liver lipophagy ameliorates nonalcoholic steatohepatitis through extracellular lipid secretion.
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| Cathepsin B Is Not an Intrinsic Factor Related to Asparaginase Resistance of the Acute Lymphoblastic Leukemia REH Cell Line. Costa IM, Effer B, Costa-Silva TA, Chen C, Ciccone MF, Pessoa A, Dos Santos CO, Monteiro G. Int J Mol Sci. 2023 Jul 7;24(13):11215. doi: 10.3390/ijms241311215. PubMed |
| Polycomb repressive complex 2 binds and stabilizes NANOG to suppress differentiation-related genes to promote self-renewal. Yeh DW, Liu C, Hernandez JC, Tahara SM, Tsukamoto H, Machida K. iScience. 2023 Jun 7;26(7):107035. doi: 10.1016/j.isci.2023.107035. eCollection 2023 Jul 21. PubMed |
| LKB1 loss promotes colorectal cancer cell metastasis through regulating TNIK expression and actin cytoskeleton remodeling. Hu G, Huang N, Zhang J, Zhang D, Wang S, Zhang Y, Wang L, Du Y, Kuang S, Ma K, Zhu H, Xu N, Liu M. Mol Carcinog. 2023 Jul 14. doi: 10.1002/mc.23606. PubMed |
| RAS-dependent RAF-MAPK hyperactivation by pathogenic RIT1 is a therapeutic target in Noonan syndrome-associated cardiac hypertrophy. Cuevas-Navarro A, Wagner M, Van R, Swain M, Mo S, Columbus J, Allison MR, Cheng A, Messing S, Turbyville TJ, Simanshu DK, Sale MJ, McCormick F, Stephen AG, Castel P. Sci Adv. 2023 Jul 14;9(28):eadf4766. doi: 10.1126/sciadv.adf4766. Epub 2023 Jul 14. PubMed |
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| Coding and non-coding elements comprise a regulatory network controlling transcription in Kaposi's sarcoma-associated herpesvirus. Morgens DW, Gulyas L, Souza AS, Glaunsinger BA. bioRxiv. 2023 Jul 8:2023.07.08.548212. doi: 10.1101/2023.07.08.548212. Preprint. PubMed |
| Structures of p53/BCL-2 complex suggest a mechanism for p53 to antagonize BCL-2 activity. Wei H, Wang H, Wang G, Qu L, Jiang L, Dai S, Chen X, Zhang Y, Chen Z, Li Y, Guo M, Chen Y. Nat Commun. 2023 Jul 18;14(1):4300. doi: 10.1038/s41467-023-40087-2. PubMed |
| Contemporary human H3N2 influenza A viruses require a low threshold of suitable glycan receptors for efficient infection. Spruit CM, Sweet IR, Maliepaard JCL, Bestebroer T, Lexmond P, Qiu B, Damen MJA, Fouchier RAM, Reiding KR, Snijder J, Herfst S, Boons GJ, de Vries RP. Glycobiology. 2023 Oct 30;33(10):784-800. doi: 10.1093/glycob/cwad060. PubMed |
The SUMO-NIP45 pathway processes toxic DNA catenanes to prevent mitotic failure.
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| Targeting polyploid giant cancer cells potentiates a therapeutic response and overcomes resistance to PARP inhibitors in ovarian cancer. Zhang X, Yao J, Li X, Niu N, Liu Y, Hajek RA, Peng G, Westin S, Sood AK, Liu J. Sci Adv. 2023 Jul 21;9(29):eadf7195. doi: 10.1126/sciadv.adf7195. Epub 2023 Jul 21. PubMed |
| Radio-immunotherapy by (188)Re-antiCD20 and stable silencing of IGF-IR in Raji cells, new insight in treatment of lymphoma. Nasehi L, Abdolhossein Zadeh B, Rahimi H, Hossein Ghahremani M. Gene. 2023 Oct 5;882:147638. doi: 10.1016/j.gene.2023.147638. Epub 2023 Jul 20. PubMed |
| Long non-coding RNA CCHE1 modulates LDHA-mediated glycolysis and confers chemoresistance to melanoma cells. Ding Z, Yang J, Wu B, Wu Y, Guo F. Cancer Metab. 2023 Jul 21;11(1):10. doi: 10.1186/s40170-023-00309-z. PubMed |
| Lipoylation is dependent on the ferredoxin FDX1 and dispensable under hypoxia in human cells. Joshi PR, Sadre S, Guo XA, McCoy JG, Mootha VK. J Biol Chem. 2023 Jul 20:105075. doi: 10.1016/j.jbc.2023.105075. PubMed |
| Serum-free lentiviral vector production is compatible with medium-resident nuclease activity arising from adherent HEK293T host cells engineered with a nuclease-encoding transgene. Ali S, Rivera M, Ward J, Keshavarz-Moore E, Mason C, Nesbeth DN. Heliyon. 2023 Jun 7;9(6):e17067. doi: 10.1016/j.heliyon.2023.e17067. eCollection 2023 Jun. PubMed |
| NAT10-mediated RNA acetylation enhances HNRNPUL1 mRNA stability to contribute cervical cancer progression. Long Y, Ren Y, Wei Q, Mobet Y, Liu Y, Zhao H, Liu T, Cheng L, Yi P. Int J Med Sci. 2023 Jun 26;20(8):1079-1090. doi: 10.7150/ijms.83828. eCollection 2023. PubMed |
| Autonomous action and cooperativity between the ONECUT2 transcription factor and its 3' untranslated region. Steadman K, You S, Srinivas DV, Mouakkad L, Yan Y, Kim M, Venugopal SV, Tanaka H, Freeman MR. Front Cell Dev Biol. 2023 Jul 5;11:1206259. doi: 10.3389/fcell.2023.1206259. eCollection 2023. PubMed |
| Upregulation of Somatostatin Receptor Type 2 Improves 177Lu-DOTATATE Therapy in Receptor-Deficient Pancreatic Neuroendocrine Tumor Model. Sharma R, Earla B, Baidoo KE, Zeiger MA, Madigan JP, Escorcia FE, Sadowski SM. Mol Cancer Ther. 2023 Jul 22:MCT-22-0798. doi: 10.1158/1535-7163.MCT-22-0798. PubMed |
| Functional annotation of variants of the BRCA2 gene via locally haploid human pluripotent stem cells. Li H, Bartke R, Zhao L, Verma Y, Horacek A, Rechav Ben-Natan A, Pangilinan GR, Krishnappa N, Nielsen R, Hockemeyer D. Nat Biomed Eng. 2023 Jul 24. doi: 10.1038/s41551-023-01065-7. PubMed |
| Cas phosphorylation regulates focal adhesion assembly. Kumar S, Stainer A, Dubrulle J, Simpkins C, Cooper JA. Elife. 2023 Jul 25;12:e90234. doi: 10.7554/eLife.90234. PubMed |
| Epigenetic silencing of HTATIP2 in glioblastoma contributes to treatment resistance by enhancing nuclear translocation of the DNA repair protein MPG. Nguyen TT, Rajakannu P, Pham MDT, Weman L, Jucht A, Buri MC, Van Dommelen K, Hegi ME. Mol Oncol. 2023 Jul 25. doi: 10.1002/1878-0261.13494. PubMed |
| Optogenetic modulation of guanine nucleotide exchange factors of Ras superfamily proteins directly controls cell shape and movement. Pal DS, Lin Y, Zhan H, Banerjee T, Kuhn J, Providence S, Devreotes PN. Front Cell Dev Biol. 2023 Jul 10;11:1195806. doi: 10.3389/fcell.2023.1195806. eCollection 2023. PubMed |
| CBF-Beta Mitigates PI3K-Alpha-Specific Inhibitor Killing through PIM1 in PIK3CA-Mutant Gastric Cancer. Stanland LJ, Ang HX, Hoj JP, Chu Y, Tan P, Wood KC, Luftig MA. Mol Cancer Res. 2023 Nov 1;21(11):1148-1162. doi: 10.1158/1541-7786.MCR-23-0034. PubMed |
| T Cells Expressing CAR Equipped With Extracellular Domain of BTLA Are Effective Against HVEM-over-expressing Melanoma Cell Lines. Kim Y, Kim JE, Lee DY, Choi JU, Park JS, Lee HK, Choi SU, Park S, Park CH. Anticancer Res. 2023 Aug;43(8):3419-3427. doi: 10.21873/anticanres.16517. PubMed |
| Protein arginine methyltransferase 5 (PRMT5) is an actionable therapeutic target in CDK4/6 inhibitor-resistant ER+/RB-deficient breast cancer. Lin CC, Chang TC, Wang Y, Guo L, Gao Y, Bikorimana E, Lemoff A, Fang Y, Zhang H, Zhang Y, Ye D, Soria-Bretones I, Servetto A, Lee KM, Luo X, Otto J, Akamatsu H, Napolitano F, Mani R, Cescon D, Xu L, Xie Y, Mendell J, Hanker A, Arteaga C. Res Sq. 2023 Jul 10:rs.3.rs-2966905. doi: 10.21203/rs.3.rs-2966905/v1. Preprint. PubMed |
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| Chimeric HLA antibody receptor T cells for targeted therapy of antibody-mediated rejection in transplantation. Betriu S, Rovira J, Arana C, Garcia-Busquets A, Matilla-Martinez M, Ramirez-Bajo MJ, Banon-Maneus E, Lazo-Rodriguez M, Bartolo-Ibars A, Claas FHJ, Mulder A, Heidt S, Juan M, Bayes-Genis B, Campistol JM, Palou E, Diekmann F. HLA. 2023 Jul 28. doi: 10.1111/tan.15156. PubMed |
| Inhibition of GLI Transcriptional Activity and Prostate Cancer Cell Growth and Proliferation by DAX1. Hong SP, Kim KW, Ahn SK. Curr Issues Mol Biol. 2023 Jun 27;45(7):5347-5361. doi: 10.3390/cimb45070339. PubMed |
| Differential Inhibition of Anaplerotic Pyruvate Carboxylation and Glutaminolysis-Fueled Anabolism Underlies Distinct Toxicity of Selenium Agents in Human Lung Cancer. Fan TW, Winnike J, Al-Attar A, Belshoff AC, Lorkiewicz PK, Tan JL, Wu M, Higashi RM, Lane AN. Metabolites. 2023 Jun 21;13(7):774. doi: 10.3390/metabo13070774. PubMed |
| Genome-wide screening for regulators of degradation of insulin secretory granules with a fluorescent reporter. Kanai A, Nishida Y, Iwamoto T, Yokota M, Aoyama S, Ueki K, Ito M, Uzawa H, Iida H, Koike M, Watada H. Biochem Biophys Res Commun. 2023 Jul 20;676:132-140. doi: 10.1016/j.bbrc.2023.07.040. PubMed |
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| The cell cycle protein MAD2 facilitates endocytosis of the serotonin transporter in the neuronal soma. Koban F, Freissmuth M. EMBO Rep. 2023 Oct 9;24(10):e53408. doi: 10.15252/embr.202153408. Epub 2023 Aug 2. PubMed |
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| Ribosome subunit attrition and activation of the p53-MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition. Howard GC, Wang J, Rose KL, Jones C, Patel P, Tsui T, Florian AC, Vlach L, Lorey SL, Grieb BC, Smith BN, Slota MJ, Reynolds EM, Goswami S, Savona MR, Mason FM, Lee T, Fesik SW, Liu Q, Tansey WP. bioRxiv [Preprint]. 2024 Jan 10:2023.07.26.550648. doi: 10.1101/2023.07.26.550648. PubMed |
| Analysis of the complex between MBD2 and the histone deacetylase core of NuRD reveals key interactions critical for gene silencing. Leighton GO, Shang S, Hageman S, Ginder GD, Williams DC Jr. Proc Natl Acad Sci U S A. 2023 Aug 15;120(33):e2307287120. doi: 10.1073/pnas.2307287120. Epub 2023 Aug 8. PubMed |
| Inactivating TDP2 missense mutation in siblings with congenital abnormalities reminiscent of fanconi anemia. Zagnoli-Vieira G, Brazina J, Van Den Bogaert K, Huybrechts W, Molenaers G, Caldecott KW, Van Esch H. Hum Genet. 2023 Sep;142(9):1417-1427. doi: 10.1007/s00439-023-02589-3. Epub 2023 Aug 10. PubMed |
| ER-associated degradation in cystinosis pathogenesis and the prospects of precision medicine. Venkatarangan V, Zhang W, Yang X, Thoene J, Hahn SH, Li M. J Clin Invest. 2023 Oct 2;133(19):e169551. doi: 10.1172/JCI169551. PubMed |
| Extravillous trophoblast cell lineage development is associated with active remodeling of the chromatin landscape. Varberg KM, Dominguez EM, Koseva B, Varberg JM, McNally RP, Moreno-Irusta A, Wesley ER, Iqbal K, Cheung WA, Schwendinger-Schreck C, Smail C, Okae H, Arima T, Lydic M, Holoch K, Marsh C, Soares MJ, Grundberg E. Nat Commun. 2023 Aug 10;14(1):4826. doi: 10.1038/s41467-023-40424-5. PubMed |
| RXR Agonists Enhance Lenalidomide Anti-Myeloma Activity and T Cell Functions while Retaining Glucose-Lowering Effect. Wu J, Wang X, Zhang M, Mathews P, Kang Y. Cells. 2023 Aug 3;12(15):1993. doi: 10.3390/cells12151993. PubMed |
| Establishment and Molecular Characterization of an In Vitro Model for PARPi-Resistant Ovarian Cancer. Klotz DM, Schwarz FM, Dubrovska A, Schuster K, Theis M, Kruger A, Kutz O, Link T, Wimberger P, Drukewitz S, Buchholz F, Thomale J, Kuhlmann JD. Cancers (Basel). 2023 Jul 25;15(15):3774. doi: 10.3390/cancers15153774. PubMed |
| Elafin as a Prognostic Marker in Esophageal Squamous Cell Carcinoma: A Pilot Study Using Three-Dimensional Imaging and Genomic Profiling. Chen WC, Wu CC, Liu YP, Zhuo GY, Wang YK, Chen YH, Chen CC, Wang YH, Wu MT, Wu IC. Cancers (Basel). 2023 Jul 27;15(15):3825. doi: 10.3390/cancers15153825. PubMed |
| Downregulation of DNA methylation enhances differentiation of THP-1 cells and induces M1 polarization of differentiated macrophages. Park J, Luo Y, Park JW, Kim SH, Hong YJ, Lim Y, Seo YJ, Bae J, Seo SB. Sci Rep. 2023 Aug 12;13(1):13132. doi: 10.1038/s41598-023-40362-8. PubMed |
| A Size Filter Regulates Apical Protein Sorting. de Caestecker C, Macara IG. Res Sq [Preprint]. 2023 Aug 4:rs.3.rs-3210598. doi: 10.21203/rs.3.rs-3210598/v1. PubMed |
| RBL2 represses the transcriptional activity of Multicilin to inhibit multiciliogenesis. Quiroz EJ, Kim S, Gautam LK, Borok Z, Kintner C, Ryan AL. bioRxiv [Preprint]. 2023 Aug 4:2023.08.04.551992. doi: 10.1101/2023.08.04.551992. PubMed |
| Interface-guided phenotyping of coding variants in the transcription factor RUNX1 with SEUSS. Ozturk K, Panwala R, Sheen J, Ford K, Payne N, Zhang DE, Hutter S, Haferlach T, Ideker T, Mali P, Carter H. bioRxiv [Preprint]. 2023 Aug 4:2023.08.03.551876. doi: 10.1101/2023.08.03.551876. PubMed |
PTEN deficiency exposes a requirement for an ARF GTPase module for integrin-dependent invasion in ovarian cancer.
Nikolatou K, Sandilands E, Roman-Fernandez A, Cumming EM, Freckmann E, Lilla S, Buetow L, McGarry L, Neilson M, Shaw R, Strachan D, Miller C, Huang DT, McNeish IA, Norman JC, Zanivan S, Bryant DM.
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| In vivo screening characterizes chromatin factor functions during normal and malignant hematopoiesis. Lara-Astiaso D, Goni-Salaverri A, Mendieta-Esteban J, Narayan N, Del Valle C, Gross T, Giotopoulos G, Beinortas T, Navarro-Alonso M, Aguado-Alvaro LP, Zazpe J, Marchese F, Torrea N, Calvo IA, Lopez CK, Alignani D, Lopez A, Saez B, Taylor-King JP, Prosper F, Fortelny N, Huntly BJP. Nat Genet. 2023 Sep;55(9):1542-1554. doi: 10.1038/s41588-023-01471-2. Epub 2023 Aug 14. PubMed |
| Pharmacological perturbation of the phase-separating protein SMNDC1. Enders L, Siklos M, Borggrafe J, Gaussmann S, Koren A, Malik M, Tomek T, Schuster M, Reinis J, Hahn E, Rukavina A, Reicher A, Casteels T, Bock C, Winter GE, Hannich JT, Sattler M, Kubicek S. Nat Commun. 2023 Aug 16;14(1):4504. doi: 10.1038/s41467-023-40124-0. PubMed |
KDM6A epigenetically regulates subtype plasticity in small cell lung cancer.
Duplaquet L, Li Y, Booker MA, Xie Y, Olsen SN, Patel RA, Hong D, Hatton C, Denize T, Walton E, Laimon YN, Li R, Jiang Y, Bronson RT, Southard J, Li S, Signoretti S, Qiu X, Cejas P, Armstrong SA, Long HW, Tolstorukov MY, Haffner MC, Oser MG.
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| TIGIT can inhibit T cell activation via ligation-induced nanoclusters, independent of CD226 co-stimulation. Worboys JD, Vowell KN, Hare RK, Ambrose AR, Bertuzzi M, Conner MA, Patel FP, Zammit WH, Gali-Moya J, Hazime KS, Jones KL, Rey C, Jonjic S, Rovis TL, Tannahill GM, Cruz De Matos GDS, Waight JD, Davis DM. Nat Commun. 2023 Aug 18;14(1):5016. doi: 10.1038/s41467-023-40755-3. PubMed |
| Reactivated endogenous retroviruses promote protein aggregate spreading. Liu S, Heumuller SE, Hossinger A, Muller SA, Buravlova O, Lichtenthaler SF, Denner P, Vorberg IM. Nat Commun. 2023 Aug 18;14(1):5034. doi: 10.1038/s41467-023-40632-z. PubMed |
Evaluation of the determinants for improved pluripotency induction and maintenance by engineered SOX17.
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| A genome-wide atlas of human cell morphology. Ramezani M, Bauman J, Singh A, Weisbart E, Yong J, Lozada M, Way GP, Kavari SL, Diaz C, Haghighi M, Batista TM, Perez-Schindler J, Claussnitzer M, Singh S, Cimini BA, Blainey PC, Carpenter AE, Jan CH, Neal JT. bioRxiv [Preprint]. 2023 Aug 7:2023.08.06.552164. doi: 10.1101/2023.08.06.552164. PubMed |
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Weng M, Hu H, Graus MS, Tan DS, Gao Y, Ren S, Ho DHH, Langer J, Holzner M, Huang Y, Ling GS, Lai CSW, Francois M, Jauch R.
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Circadian clock regulator Bmal1 gates axon regeneration via Tet3 epigenetics in mouse sensory neurons.
Halawani D, Wang Y, Ramakrishnan A, Estill M, He X, Shen L, Friedel RH, Zou H.
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| Cancer-cell-secreted miR-204-5p induces leptin signalling pathway in white adipose tissue to promote cancer-associated cachexia. Hu Y, Liu L, Chen Y, Zhang X, Zhou H, Hu S, Li X, Li M, Li J, Cheng S, Liu Y, Xu Y, Yan W. Nat Commun. 2023 Aug 24;14(1):5179. doi: 10.1038/s41467-023-40571-9. PubMed |
| RNAPII-dependent ATM signaling at collisions with replication forks. Einig E, Jin C, Andrioletti V, Macek B, Popov N. Nat Commun. 2023 Aug 24;14(1):5147. doi: 10.1038/s41467-023-40924-4. PubMed |
The ABL-MYC axis controls WIPI1-enhanced autophagy in lifespan extension.
Sporbeck K, Haas ML, Pastor-Maldonado CJ, Schussele DS, Hunter C, Takacs Z, Diogo de Oliveira AL, Franz-Wachtel M, Charsou C, Pfisterer SG, Gubas A, Haller PK, Knorr RL, Kaulich M, Macek B, Eskelinen EL, Simonsen A, Proikas-Cezanne T.
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| Targeted inhibition of protein synthesis renders cancer cells vulnerable to apoptosis by unfolded protein response. Gsottberger F, Meier C, Ammon A, Parker S, Wendland K, George R, Petkovic S, Mellenthin L, Emmerich C, Lutzny-Geier G, Metzler M, Mackensen A, Chandramohan V, Muller F. Cell Death Dis. 2023 Aug 26;14(8):561. doi: 10.1038/s41419-023-06055-w. PubMed |
| Structural and functional insights into the modulation of T cell costimulation by monkeypox virus protein M2. Yang S, Wang Y, Yu F, Cheng R, Zhang Y, Zhou D, Ren X, Deng Z, Zhao H. Nat Commun. 2023 Aug 25;14(1):5186. doi: 10.1038/s41467-023-40748-2. PubMed |
| Establishment of Replication Deficient Vesicular Stomatitis Virus for Studies of PEDV Spike-Mediated Cell Entry and Its Inhibition. Luo H, Lv L, Yi J, Zhou Y, Liu C. Microorganisms. 2023 Aug 12;11(8):2075. doi: 10.3390/microorganisms11082075. PubMed |
| Testicular germ cell tumour cells release microRNA-containing extracellular vesicles that induce phenotypic and genotypic changes in cells of the tumour microenvironment. Alonso-Crisostomo L, Trendell J, Ferraresso M, Bailey S, Ward D, Scurlock ZGL, Wenlock SC, Bastos CAP, Jugdaohsingh R, Faria NJ, Enright AJ, Scarpini CG, Coleman N, Murray MJ. Int J Cancer. 2024 Jan 15;154(2):372-388. doi: 10.1002/ijc.34697. Epub 2023 Aug 26. PubMed |
| LncRNA GAS5-hnRNPK axis inhibited ovarian cancer progression via inhibition of AKT signaling in ovarian cancer cells. Zhang T, Leng Y, Duan M, Li Z, Ma Y, Huang C, Shi Q, Wang Y, Wang C, Liu D, Zhao X, Cheng S, Liu A, Zhou Y, Liu J, Pan Z, Zhang H, Shen L, Zhao H. Discov Oncol. 2023 Aug 28;14(1):157. doi: 10.1007/s12672-023-00764-6. PubMed |
| Characterization of enhancer activity in early human neurodevelopment using Massively parallel reporter assay (MPRA) and forebrain organoids. Capauto D, Wang Y, Wu F, Norton S, Mariani J, Inoue F, Crawford GE, Ahituv N, Abyzov A, Vaccarino FM. bioRxiv [Preprint]. 2023 Aug 14:2023.08.14.553170. doi: 10.1101/2023.08.14.553170. PubMed |
| Mechanical force regulates ligand binding and function of PD-1. Li K, Cardenas-Lizana P, Kellner AV, Yuan Z, Ahn E, Lyu J, Li Z, Salaita K, Ahmed R, Zhu C. bioRxiv [Preprint]. 2023 Aug 15:2023.08.13.553152. doi: 10.1101/2023.08.13.553152. PubMed |
| CRISPR screens decode cancer cell pathways that trigger gammadelta T cell detection. Mamedov MR, Vedova S, Freimer JW, Sahu AD, Ramesh A, Arce MM, Meringa AD, Ota M, Chen PA, Hanspers K, Nguyen VQ, Takeshima KA, Rios AC, Pritchard JK, Kuball J, Sebestyen Z, Adams EJ, Marson A. Nature. 2023 Sep;621(7977):188-195. doi: 10.1038/s41586-023-06482-x. Epub 2023 Aug 30. PubMed |
| SAP30 promotes breast tumor progression by bridging the transcriptional corepressor SIN3 complex and MLL1. Bao L, Kumar A, Zhu M, Peng Y, Xing C, Wang JE, Wang Y, Luo W. J Clin Invest. 2023 Sep 1;133(17):e168362. doi: 10.1172/JCI168362. PubMed |
| The Endolysosomal Transporter DMT1 is Required for Morphine Regulation of Neuronal Ferritin Heavy Chain. Irollo E, Nash B, Luchetta J, Brandimarti R, Meucci O. J Neuroimmune Pharmacol. 2023 Sep;18(3):495-508. doi: 10.1007/s11481-023-10082-x. Epub 2023 Sep 4. PubMed |
| Recapitulation of patient-specific 3D chromatin conformation using machine learning. Xu D, Forbes AN, Cohen S, Palladino A, Karadimitriou T, Khurana E. Cell Rep Methods. 2023 Sep 25;3(9):100578. doi: 10.1016/j.crmeth.2023.100578. Epub 2023 Sep 5. PubMed |
| TGS1/PIMT regulates pro-inflammatory macrophage mediated paracrine insulin resistance: Crosstalk between macrophages and skeletal muscle cells. Challa NL, Sarkar A, Kapettu S, Phanithi PB, Chakrabarti P, Parsa KVL, Misra P. Biochim Biophys Acta Mol Basis Dis. 2024 Jan;1870(1):166878. doi: 10.1016/j.bbadis.2023.166878. Epub 2023 Sep 4. PubMed |
| Structure shows that the BIR2 domain of E3 ligase XIAP binds across the RIPK2 kinase dimer interface. Lethier M, Huard K, Hons M, Favier A, Brutscher B, Boeri Erba E, Abbott DW, Cusack S, Pellegrini E. Life Sci Alliance. 2023 Sep 6;6(11):e202201784. doi: 10.26508/lsa.202201784. Print 2023 Nov. PubMed |
Optogenetic engineering of STING signaling allows remote immunomodulation to enhance cancer immunotherapy.
Dou Y, Chen R, Liu S, Lee YT, Jing J, Liu X, Ke Y, Wang R, Zhou Y, Huang Y.
Nat Commun. 2023 Sep 6;14(1):5461. doi: 10.1038/s41467-023-41164-2.
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| Host-derived growth factors drive ERK phosphorylation and MCL1 expression to promote osteosarcoma cell survival during metastatic lung colonization. McAloney CA, Makkawi R, Budhathoki Y, Cannon MV, Franz EM, Gross AC, Cam M, Vetter TA, Duhen R, Davies AE, Roberts RD. Cell Oncol (Dordr). 2024 Feb;47(1):259-282. doi: 10.1007/s13402-023-00867-w. Epub 2023 Sep 7. PubMed |
| Clonal dynamics limits detection of selection in tumour xenograft CRISPR/Cas9 screens. Lee TW, Hunter FW, Tsai P, Print CG, Wilson WR, Jamieson SMF. Cancer Gene Ther. 2023 Dec;30(12):1610-1623. doi: 10.1038/s41417-023-00664-5. Epub 2023 Sep 8. PubMed |
| Targeting Oncogenic Mutant p53 and BCL-2 for Small Cell Lung Cancer Treatment. Neely V, Manchikalapudi A, Nguyen K, Dalton K, Hu B, Koblinski JE, Faber AC, Deb S, Harada H. Int J Mol Sci. 2023 Aug 23;24(17):13082. doi: 10.3390/ijms241713082. PubMed |
| SOD1 is a synthetic lethal target in PPM1D-mutant leukemia cells. Zhang L, Hsu JI, Braekeleer ED, Chen CW, Patel TD, Martell AG, Guzman AG, Wohlan K, Waldvogel SM, Urya H, Tovy A, Callen E, Murdaugh R, Richard R, Jansen S, Vissers L, de Vries BBA, Nussenzweig A, Huang S, Coarfa C, Anastas JN, Takahashi K, Vassiliou G, Goodell MA. bioRxiv [Preprint]. 2024 Jan 17:2023.08.31.555634. doi: 10.1101/2023.08.31.555634. PubMed |
A split and inducible adenine base editor for precise in vivo base editing.
Zeng H, Yuan Q, Peng F, Ma D, Lingineni A, Chee K, Gilberd P, Osikpa EC, Sun Z, Gao X.
Nat Commun. 2023 Sep 11;14(1):5573. doi: 10.1038/s41467-023-41331-5.
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| In situ PEGylation of CAR T cells alleviates cytokine release syndrome and neurotoxicity. Gong N, Han X, Xue L, El-Mayta R, Metzloff AE, Billingsley MM, Hamilton AG, Mitchell MJ. Nat Mater. 2023 Dec;22(12):1571-1580. doi: 10.1038/s41563-023-01646-6. Epub 2023 Sep 11. PubMed |
| Direct measurement of engineered cancer mutations and their transcriptional phenotypes in single cells. Kim HS, Grimes SM, Chen T, Sathe A, Lau BT, Hwang GH, Bae S, Ji HP. Nat Biotechnol. 2023 Sep 11. doi: 10.1038/s41587-023-01949-8. PubMed |
| Temporal analyses reveal a pivotal role for sense and antisense enhancer RNAs in coordinate immunoglobulin lambda locus activation. Gao Z, Smith AL, Scott JNF, Bevington SL, Boyes J. Nucleic Acids Res. 2023 Oct 27;51(19):10344-10363. doi: 10.1093/nar/gkad741. PubMed |
| The FAM104 proteins VCF1/2 promote the nuclear localization of p97/VCP. Korner M, Meyer SR, Marincola G, Kern MJ, Grimm C, Schuelein-Voelk C, Fischer U, Hofmann K, Buchberger A. Elife. 2023 Sep 15;12:e92409. doi: 10.7554/eLife.92409. PubMed |
| Activation of melanocortin-1 receptor signaling in melanoma cells impairs T cell infiltration to dampen antitumor immunity. Cui Y, Miao Y, Cao L, Guo L, Cui Y, Yan C, Zeng Z, Xu M, Han T. Nat Commun. 2023 Sep 15;14(1):5740. doi: 10.1038/s41467-023-41101-3. PubMed |
| Phenylalanine-tRNA aminoacylation is compromised by ALS/FTD-associated C9orf72 C4G2 repeat RNA. Malnar Crnigoj M, Cercek U, Yin X, Ho MT, Repic Lampret B, Neumann M, Hermann A, Rouleau G, Suter B, Mayr M, Rogelj B. Nat Commun. 2023 Sep 16;14(1):5764. doi: 10.1038/s41467-023-41511-3. PubMed |
| An essential signaling function of cytoplasmic NELFB is independent of RNA polymerase II pausing. Pan H, Cheng X, Rodriguez PFG, Zhang X, Chung I, Jin VX, Li W, Hu Y, Li R. J Biol Chem. 2023 Nov;299(11):105259. doi: 10.1016/j.jbc.2023.105259. Epub 2023 Sep 17. PubMed |
| Reversing T Cell Exhaustion by Converting Membrane PD-1 to Its Soluble form in Jurkat Cells; Applying The CRISPR/Cas9 Exon Skipping Strategy. Yousefi-Najafabadi Z, Mehmandoostli Z, Asgari Y, Kaboli S, Falak R, Kardar GA. Cell J. 2023 Sep 9;25(9):633-644. doi: 10.22074/cellj.2023.1999548.1269. PubMed |
| GLUT3 promotes macrophage signaling and function via RAS-mediated endocytosis in atopic dermatitis and wound healing. Yu DM, Zhao J, Lee EE, Kim D, Mahapatra R, Rose EK, Zhou Z, Hosler C, El Kurdi A, Choe JY, Abel ED, Hoxhaj G, Westover KD, Cho RJ, Cheng JB, Wang RC. J Clin Invest. 2023 Nov 1;133(21):e170706. doi: 10.1172/JCI170706. PubMed |
| Whole-genome screens reveal regulators of differentiation state and context-dependent migration in human neutrophils. Belliveau NM, Footer MJ, Akdogan E, van Loon AP, Collins SR, Theriot JA. Nat Commun. 2023 Sep 18;14(1):5770. doi: 10.1038/s41467-023-41452-x. PubMed |
| Molecular basis for maternal inheritance of human mitochondrial DNA. Lee W, Zamudio-Ochoa A, Buchel G, Podlesniy P, Marti Gutierrez N, Puigros M, Calderon A, Tang HY, Li L, Mikhalchenko A, Koski A, Trullas R, Mitalipov S, Temiakov D. Nat Genet. 2023 Oct;55(10):1632-1639. doi: 10.1038/s41588-023-01505-9. Epub 2023 Sep 18. PubMed |
| Genome-Wide CRISPR Screens Identify Multiple Synthetic Lethal Targets That Enhance KRASG12C Inhibitor Efficacy. Mukhopadhyay S, Huang HY, Lin Z, Ranieri M, Li S, Sahu S, Liu Y, Ban Y, Guidry K, Hu H, Lopez A, Sherman F, Tan YJ, Lee YT, Armstrong AP, Dolgalev I, Sahu P, Zhang T, Lu W, Gray NS, Christensen JG, Tang TT, Velcheti V, Khodadadi-Jamayran A, Wong KK, Neel BG. Cancer Res. 2023 Dec 15;83(24):4095-4111. doi: 10.1158/0008-5472.CAN-23-2729. PubMed |
| C-Myc-induced hypersialylation of small cell lung cancer facilitates pro-tumoral phenotypes of macrophages. Tian L, Li H, Zhao P, Liu Y, Lu Y, Zhong R, Jin Y, Tan T, Cheng Y. iScience. 2023 Aug 29;26(10):107771. doi: 10.1016/j.isci.2023.107771. eCollection 2023 Oct 20. PubMed |
| Differential nanoscale organization of excitatory synapses onto excitatory vs inhibitory neurons. Dharmasri PA, Levy AD, Blanpied TA. bioRxiv [Preprint]. 2023 Sep 7:2023.09.06.556279. doi: 10.1101/2023.09.06.556279. PubMed |
| The NCOR-HDAC3 co-repressive complex modulates the leukemogenic potential of the transcription factor ERG. Kugler E, Madiwale S, Yong D, Thoms JAI, Birger Y, Sykes DB, Schmoellerl J, Drakul A, Priebe V, Yassin M, Aqaqe N, Rein A, Fishman H, Geron I, Chen CW, Raught B, Liu Q, Ogana H, Liedke E, Bourquin JP, Zuber J, Milyavsky M, Pimanda J, Prive GG, Izraeli S. Nat Commun. 2023 Sep 21;14(1):5871. doi: 10.1038/s41467-023-41067-2. PubMed |
| FBXW2 suppresses breast tumorigenesis by targeting AKT-Moesin-SKP2 axis. Barik GK, Sahay O, Mukhopadhyay A, Manne RK, Islam S, Roy A, Nath S, Santra MK. Cell Death Dis. 2023 Sep 22;14(9):623. doi: 10.1038/s41419-023-06127-x. PubMed |
| Protocol to capture transcription factor-mediated 3D chromatin interactions using affinity tag-based BL-HiChIP. Ren R, Hua Y, Wang H. STAR Protoc. 2023 Dec 15;4(4):102589. doi: 10.1016/j.xpro.2023.102589. Epub 2023 Sep 21. PubMed |
| BAP1 promotes osteoclast function by metabolic reprogramming. Rohatgi N, Zou W, Li Y, Cho K, Collins PL, Tycksen E, Pandey G, DeSelm CJ, Patti GJ, Dey A, Teitelbaum SL. Nat Commun. 2023 Sep 22;14(1):5923. doi: 10.1038/s41467-023-41629-4. PubMed |
| A novel CAR-T cell product targeting CD74 is an effective therapeutic approach in preclinical mantle cell lymphoma models. Chan WK, Williams J, Sorathia K, Pray B, Abusaleh K, Bian Z, Sharma A, Hout I, Nishat S, Hanel W, Sloan SL, Yasin A, Denlinger N, Zhang X, Muthusamy N, Vasu S, de Lima M, Yang Y, Baiocchi R, Alinari L. Exp Hematol Oncol. 2023 Sep 22;12(1):79. doi: 10.1186/s40164-023-00437-8. PubMed |
| GiRAFR improves gRNA detection and annotation in single-cell CRISPR screens. Yu Q, Van Minsel P, Galle E, Thienpont B. Commun Biol. 2023 Sep 23;6(1):975. doi: 10.1038/s42003-023-05351-7. PubMed |
| Cas13d-mediated isoform-specific RNA knockdown with a unified computational and experimental toolbox. Schertzer MD, Stirn A, Isaev K, Pereira L, Das A, Harbison C, Park SH, Wessels HH, Sanjana NE, Knowles DA. bioRxiv [Preprint]. 2023 Sep 13:2023.09.12.557474. doi: 10.1101/2023.09.12.557474. PubMed |
| ATLAS: A rationally designed anterograde transsynaptic tracer. Rivera JF, Weng W, Huang H, Rao S, Herring BE, Arnold DB. bioRxiv [Preprint]. 2023 Sep 13:2023.09.12.557425. doi: 10.1101/2023.09.12.557425. PubMed |
| A Meta-Atlas of the Developing Human Cortex Identifies Modules Driving Cell Subtype Specification. Nano PR, Fazzari E, Azizad D, Nguyen CV, Wang S, Kan RL, Wick B, Haeussler M, Bhaduri A. bioRxiv [Preprint]. 2023 Sep 13:2023.09.12.557406. doi: 10.1101/2023.09.12.557406. PubMed |
| Nectin-3 and shed forms of CSPG4 can serve as epithelial cell receptors for Clostridioides difficile TcdB. Childress KO, Cencer CS, Tyska MJ, Lacy DB. mBio. 2023 Oct 31;14(5):e0185723. doi: 10.1128/mbio.01857-23. Epub 2023 Sep 25. PubMed |
| KCNQ potassium channels modulate Wnt activity in gastro-oesophageal adenocarcinomas. Shorthouse D, Zhuang L, Rahrmann EP, Kosmidou C, Wickham Rahrmann K, Hall M, Greenwood B, Devonshire G, Gilbertson RJ, Fitzgerald RC, Hall BA. Life Sci Alliance. 2023 Sep 25;6(12):e202302124. doi: 10.26508/lsa.202302124. Print 2023 Dec. PubMed |
| Dissecting key regulators of transcriptome kinetics through scalable single-cell RNA profiling of pooled CRISPR screens. Xu Z, Sziraki A, Lee J, Zhou W, Cao J. Nat Biotechnol. 2023 Sep 25. doi: 10.1038/s41587-023-01948-9. PubMed |
| Defective quality control autophagy in Hyperhomocysteinemia promotes ER stress and consequent neuronal apoptosis through proteotoxicity. Kaur B, Sharma PK, Chatterjee B, Bissa B, Nattarayan V, Ramasamy S, Bhat A, Lal M, Samaddar S, Banerjee S, Roy SS. Cell Commun Signal. 2023 Sep 25;21(1):258. doi: 10.1186/s12964-023-01288-w. PubMed |
| Tetraspanin 1 regulates papillary thyroid tumor growth and metastasis through c-Myc-mediated glycolysis. Han J, Xie C, Liu B, Wang Y, Pang R, Bi W, Sheng R, He G, Kong L, Yu J, Ding Z, Chen L, Jia J, Zhang J, Nie C. Cancer Sci. 2023 Dec;114(12):4535-4547. doi: 10.1111/cas.15970. Epub 2023 Sep 26. PubMed |
| TGS1/PIMT knockdown reduces lipid accumulation in adipocytes, limits body weight gain and promotes insulin sensitivity in mice. Edwin RK, Acharya LP, Maity SK, Chakrabarti P, Tantia O, Joshi MB, Satyamoorthy K, Parsa KVL, Misra P. Biochim Biophys Acta Mol Basis Dis. 2024 Jan;1870(1):166896. doi: 10.1016/j.bbadis.2023.166896. Epub 2023 Sep 24. PubMed |
| Reovirus infection of tumor cells reduces the expression of NKG2D ligands, leading to impaired NK-cell cytotoxicity and functionality. Khaleafi R, Zeleznjak J, Cordela S, Drucker S, Rovis TL, Jonjic S, Bar-On Y. Front Immunol. 2023 Sep 11;14:1231782. doi: 10.3389/fimmu.2023.1231782. eCollection 2023. PubMed |
| Human cytomegalovirus attenuates AKT activity by destabilizing insulin receptor substrate proteins. Domma AJ, Henderson LA, Goodrum FD, Moorman NJ, Kamil JP. J Virol. 2023 Oct 31;97(10):e0056323. doi: 10.1128/jvi.00563-23. Epub 2023 Sep 27. PubMed |
| An Animal Model for Chronic Meningeal Inflammation and Inflammatory Demyelination of the Cerebral Cortex. Enz LS, Winkler A, Wrzos C, Dasen B, Nessler S, Stadelmann C, Schaeren-Wiemers N. Int J Mol Sci. 2023 Sep 9;24(18):13893. doi: 10.3390/ijms241813893. PubMed |
| CRISPR/Cas9-Mediated CtBP1 Gene Editing Enhances Chemosensitivity and Inhibits Metastatic Potential in Esophageal Squamous Cell Carcinoma Cells. Akhtar J, Imran M, Wang G. Int J Mol Sci. 2023 Sep 13;24(18):14030. doi: 10.3390/ijms241814030. PubMed |
| The Antiviral Factor SERINC5 Impairs the Expression of Non-Self-DNA. Shi Y, Simpson S, Ahmed SK, Chen Y, Tavakoli-Tameh A, Janaka SK, Evans DT, Serra-Moreno R. Viruses. 2023 Sep 20;15(9):1961. doi: 10.3390/v15091961. PubMed |
Curved adhesions mediate cell attachment to soft matrix fibres in three dimensions.
Zhang W, Lu CH, Nakamoto ML, Tsai CT, Roy AR, Lee CE, Yang Y, Jahed Z, Li X, Cui B.
Nat Cell Biol. 2023 Sep 28. doi: 10.1038/s41556-023-01238-1.
PubMed
Associated Plasmids |
| Molecular mechanism by which RRM2-inhibitor (cholagogue osalmid) plus bafilomycin A1 cause autophagic cell death in multiple myeloma. Guo S, Xu Z, Feng Q, Zhang H, Yu D, Li B, Hu K, Gao X, Zhang Q, Yi H, Wu X, Song D, Zhu H, Cai H, Peng Y, Zhu W, Shi J. Arch Biochem Biophys. 2023 Oct 1;747:109771. doi: 10.1016/j.abb.2023.109771. Epub 2023 Sep 28. PubMed |
| Outer membrane protein 25 of Brucella suppresses TLR-mediated expression of proinflammatory cytokines through degradation of TLRs and adaptor proteins. Murugan S, Nandi BR, Mazumdar V, Joshi K, Nandini P, Namani S, Jakka P, Radhakrishnan GK. J Biol Chem. 2023 Nov;299(11):105309. doi: 10.1016/j.jbc.2023.105309. Epub 2023 Sep 29. PubMed |
| Integrative PTEN Enhancer Discovery Reveals a New Model of Enhancer Organization. Cerda-Smith CG, Hutchinson HM, Liu A, Goel VY, Sept C, Kim H, Casani-Galdon S, Burkman KG, Bassil CF, Hansen AS, Aryee MJ, Johnstone SE, Eyler CE, Wood KC. bioRxiv [Preprint]. 2023 Sep 21:2023.09.20.558459. doi: 10.1101/2023.09.20.558459. PubMed |
| MTGR1 is required to maintain small intestinal stem cell populations. Williams C, Brown R, Zhao Y, Wang J, Chen Z, Blunt K, Pilat J, Parang B, Choksi Y, Lau K, Hiebert S, Short S, Jacobse J, Xu Y, Yang Y, Goettel J. Res Sq [Preprint]. 2023 Sep 21:rs.3.rs-3315071. doi: 10.21203/rs.3.rs-3315071/v1. PubMed |
| Differential Modulation of Polycomb-Associated Histone Marks by cBAF, pBAF, and gBAF Complexes. Bergwell M, Park J, Kirkland JG. bioRxiv [Preprint]. 2024 Jan 24:2023.09.23.557848. doi: 10.1101/2023.09.23.557848. PubMed |
| MUC13 drives cancer aggressiveness and metastasis through the YAP1-dependent pathway. Doxtater K, Tripathi MK, Sekhri R, Hafeez BB, Khan S, Zafar N, Behrman SW, Yallapu MM, Jaggi M, Chauhan SC. Life Sci Alliance. 2023 Oct 4;6(12):e202301975. doi: 10.26508/lsa.202301975. Print 2023 Dec. PubMed |
| The Physical Biology of Nucleolus Disassembly. Pham AT, Mani M, Wang XA, Vafabakhsh R. bioRxiv [Preprint]. 2023 Sep 29:2023.09.27.559731. doi: 10.1101/2023.09.27.559731. PubMed |
| Target gene regulatory network of miR-497 in angiosarcoma. Benton A, Terwilliger E, Moriarty NM, Liu B, Murphy A, Maluvac H, Shu M, Gartenhaus LE, Janson ND, Pfeffer CM, Utturkar SM, Parkinson EI, Lanman NA, Hanna JA. bioRxiv [Preprint]. 2023 Sep 25:2023.09.24.559218. doi: 10.1101/2023.09.24.559218. PubMed |
| In situ visualization of m6A sites in cellular mRNAs. Sheehan CJ, Marayati BF, Bhatia J, Meyer KD. Nucleic Acids Res. 2023 Nov 10;51(20):e101. doi: 10.1093/nar/gkad787. PubMed |
Comprehensive split TEV based protein-protein interaction screening reveals TAOK2 as a key modulator of Hippo signalling to limit growth.
Ma X, Mandausch FJ, Wu Y, Sahoo VK, Ma W, Leoni G, Hostiuc M, Wintgens JP, Qiu J, Kannaiyan N, Rossner MJ, Wehr MC.
Cell Signal. 2024 Jan;113:110917. doi: 10.1016/j.cellsig.2023.110917. Epub 2023 Oct 7.
PubMed
Associated Plasmids |
| FAM210A is essential for cold-induced mitochondrial remodeling in brown adipocytes. Qiu J, Yue F, Zhu P, Chen J, Xu F, Zhang L, Kim KH, Snyder MM, Luo N, Xu HW, Huang F, Tao WA, Kuang S. Nat Commun. 2023 Oct 10;14(1):6344. doi: 10.1038/s41467-023-41988-y. PubMed |
| The RNA methyltransferase METTL16 enhances cholangiocarcinoma growth through PRDM15-mediated FGFR4 expression. Liu N, Zhang J, Chen W, Ma W, Wu T. J Exp Clin Cancer Res. 2023 Oct 11;42(1):263. doi: 10.1186/s13046-023-02844-5. PubMed |
| NOTCH1-mutated chronic lymphocytic leukemia displays high endoplasmic reticulum stress response with druggable potential. Silva Barcelos EC, Rompietti C, Adamo FM, Dorillo E, De Falco F, Del Papa B, Baldoni S, Nogarotto M, Esposito A, Capoccia S, Geraci C, Sorcini D, Stella A, Arcaleni R, Tini V, Imbroisi Valle Errera F, Rosati E, Sportoletti P. Front Oncol. 2023 Sep 25;13:1218989. doi: 10.3389/fonc.2023.1218989. eCollection 2023. PubMed |
| Actin-dependent recruitment of AGO2 to the zonula adherens. Bridges MC, Nair-Menon J, Risner A, Jimenez DW, Daulagala AC, Kingsley C, Davis ME, Kourtidis A. Mol Biol Cell. 2023 Dec 1;34(13):ar129. doi: 10.1091/mbc.E22-03-0099-T. Epub 2023 Oct 11. PubMed |
| Nanobody-based pannexin1 channel inhibitors reduce inflammation in acute liver injury. Van Campenhout R, De Groof TWM, Kadam P, Kwak BR, Muyldermans S, Devoogdt N, Vinken M. J Nanobiotechnology. 2023 Oct 11;21(1):371. doi: 10.1186/s12951-023-02137-1. PubMed |
| Connective tissue mast cells store and release noradrenaline. Otani Y, Yoshikawa S, Nagao K, Tanaka T, Toyooka S, Fujimura A. J Physiol Sci. 2023 Oct 12;73(1):24. doi: 10.1186/s12576-023-00883-3. PubMed |
| Overexpression of FRA1 (FOSL1) Leads to Global Transcriptional Perturbations, Reduced Cellular Adhesion and Altered Cell Cycle Progression. Al-Khayyat W, Pirkkanen J, Dougherty J, Laframboise T, Dickinson N, Khaper N, Lees SJ, Mendonca MS, Boreham DR, Tai TC, Thome C, Tharmalingam S. Cells. 2023 Sep 24;12(19):2344. doi: 10.3390/cells12192344. PubMed |
| An Efficient and Cost-Effective Approach to Generate Functional Human Inducible Pluripotent Stem Cell-Derived Astrocytes. Gonzalez H, Narasipura SD, Shull T, Shetty A, Teppen TL, Naqib A, Al-Harthi L. Cells. 2023 Sep 26;12(19):2357. doi: 10.3390/cells12192357. PubMed |
| In Cerebellar Atrophy of 12-Month-Old ATM-Null Mice, Transcriptome Upregulations Concern Most Neurotransmission and Neuropeptide Pathways, While Downregulations Affect Prominently Itpr1, Usp2 and Non-Coding RNA. Reichlmeir M, Canet-Pons J, Koepf G, Nurieva W, Duecker RP, Doering C, Abell K, Key J, Stokes MP, Zielen S, Schubert R, Ivics Z, Auburger G. Cells. 2023 Oct 3;12(19):2399. doi: 10.3390/cells12192399. PubMed |
| PTBP2 attenuation facilitates fibroblast to neuron conversion by promoting alternative splicing of neuronal genes. Zhu B, Fisher E, Li L, Zhong P, Yan Z, Feng J. Stem Cell Reports. 2023 Nov 14;18(11):2268-2282. doi: 10.1016/j.stemcr.2023.09.012. Epub 2023 Oct 12. PubMed |
| DNA damage induces nuclear envelope rupture through ATR-mediated phosphorylation of lamin A/C. Kovacs MT, Vallette M, Wiertsema P, Dingli F, Loew D, Nader GPF, Piel M, Ceccaldi R. Mol Cell. 2023 Oct 19;83(20):3659-3668.e10. doi: 10.1016/j.molcel.2023.09.023. Epub 2023 Oct 12. PubMed |
| DNA damage induced by CDK4 and CDK6 blockade triggers anti-tumor immune responses through cGAS-STING pathway. Fan H, Liu W, Zeng Y, Zhou Y, Gao M, Yang L, Liu H, Shi Y, Li L, Ma J, Ruan J, Cao R, Jin X, Chen J, Cheng G, Yang H. Commun Biol. 2023 Oct 13;6(1):1041. doi: 10.1038/s42003-023-05412-x. PubMed |
| MANF stimulates autophagy and restores mitochondrial homeostasis to treat autosomal dominant tubulointerstitial kidney disease in mice. Kim Y, Li C, Gu C, Fang Y, Tycksen E, Puri A, Pietka TA, Sivapackiam J, Kidd K, Park SJ, Johnson BG, Kmoch S, Duffield JS, Bleyer AJ, Jackrel ME, Urano F, Sharma V, Lindahl M, Chen YM. Nat Commun. 2023 Oct 14;14(1):6493. doi: 10.1038/s41467-023-42154-0. PubMed |
| miR-199a and miR-199b facilitate diffuse gastric cancer progression by targeting Frizzled-6. Hong SA, Lee S, Park J, Hong M, Yoon JS, Lee H, Lee JH, Kim S, Won HS, Kang K, Ko YH, Ahn YH. Sci Rep. 2023 Oct 14;13(1):17480. doi: 10.1038/s41598-023-44716-0. PubMed |
| Carcinogen exposure enhances cancer immunogenicity by blocking the development of an immunosuppressive tumor microenvironment. Huang M, Xia Y, Li K, Shao F, Feng Z, Li T, Azin M, Demehri S. J Clin Invest. 2023 Oct 16;133(20):e166494. doi: 10.1172/JCI166494. PubMed |
Defined extracellular matrix compositions support stiffness-insensitive cell spreading and adhesion signaling.
Conway JRW, Isomursu A, Follain G, Harma V, Jou-Olle E, Pasquier N, Valimaki EPO, Rantala JK, Ivaska J.
Proc Natl Acad Sci U S A. 2023 Oct 24;120(43):e2304288120. doi: 10.1073/pnas.2304288120. Epub 2023 Oct 16.
PubMed
Associated Plasmids |
| Functional classification of DDOST variants of uncertain clinical significance in congenital disorders of glycosylation. Kas SM, Mundra PA, Smith DL, Marais R. Sci Rep. 2023 Oct 17;13(1):17648. doi: 10.1038/s41598-023-42178-y. PubMed |
A PINK1 input threshold arises from positive feedback in the PINK1/Parkin mitophagy decision circuit.
Waters CS, Angenent SB, Altschuler SJ, Wu LF.
Cell Rep. 2023 Oct 31;42(10):113260. doi: 10.1016/j.celrep.2023.113260. Epub 2023 Oct 17.
PubMed
Associated Plasmids |
| Inactive S. aureus Cas9 downregulates alpha-synuclein and reduces mtDNA damage and oxidative stress levels in human stem cell model of Parkinson's disease. Sastre D, Zafar F, Torres CAM, Piper D, Kirik D, Sanders LH, Qi LS, Schule B. Sci Rep. 2023 Oct 18;13(1):17796. doi: 10.1038/s41598-023-45078-3. PubMed |
| PCSK9 activation promotes early atherosclerosis in a vascular microphysiological system. Lee JH, Shores KL, Breithaupt JJ, Lee CS, Fodera DM, Kwon JB, Ettyreddy AR, Myers KM, Evison BJ, Suchowerska AK, Gersbach CA, Leong KW, Truskey GA. APL Bioeng. 2023 Oct 16;7(4):046103. doi: 10.1063/5.0167440. eCollection 2023 Dec. PubMed |
| A CRISPR activation screen identifies MUC-21 as critical for resistance to NK and T cell-mediated cytotoxicity. Lee DH, Ahn H, Sim HI, Choi E, Choi S, Jo Y, Yun B, Song HK, Oh SJ, Denda-Nagai K, Park CS, Irimura T, Park Y, Jin HS. J Exp Clin Cancer Res. 2023 Oct 20;42(1):272. doi: 10.1186/s13046-023-02840-9. PubMed |
| m(6)A demethylase FTO stabilizes LINK-A to exert oncogenic roles via MCM3-mediated cell-cycle progression and HIF-1alpha activation. Nan Y, Liu S, Luo Q, Wu X, Zhao P, Chang W, Zhang R, Li Y, Liu Z. Cell Rep. 2023 Oct 31;42(10):113273. doi: 10.1016/j.celrep.2023.113273. Epub 2023 Oct 19. PubMed |
| YY1 Binding to Regulatory Elements That Lack Enhancer Activity Promotes Locus Folding and Gene Activation. Gao Z, Wang M, Smith A, Boyes J. J Mol Biol. 2023 Dec 1;435(23):168315. doi: 10.1016/j.jmb.2023.168315. Epub 2023 Oct 17. PubMed |
| Role of ciliopathy protein TMEM107 in eye development: insights from a mouse model and retinal organoid. Dubaic M, Peskova L, Hampl M, Weissova K, Celiker C, Shylo NA, Hruba E, Kavkova M, Zikmund T, Weatherbee SD, Kaiser J, Barta T, Buchtova M. Life Sci Alliance. 2023 Oct 20;6(12):e202302073. doi: 10.26508/lsa.202302073. Print 2023 Dec. PubMed |
| A conformation-locking inhibitor of SLC15A4 with TASL proteostatic anti-inflammatory activity. Boeszoermenyi A, Bernaleau L, Chen X, Kartnig F, Xie M, Zhang H, Zhang S, Delacretaz M, Koren A, Hopp AK, Dvorak V, Kubicek S, Aletaha D, Yang M, Rebsamen M, Heinz LX, Superti-Furga G. Nat Commun. 2023 Oct 20;14(1):6626. doi: 10.1038/s41467-023-42070-3. PubMed |
| Development of Stable CHO-K1 Cell Lines Overexpressing Full-Length Human CD20 Antigen. Mohammadkhani N, Rahimpour A, Hoseinpoor R, Rajabibazl M. Iran Biomed J. 2023 Sep 1;27(5):269-79. doi: 10.61186/ibj.27.5.269. Epub 2023 Jul 8. PubMed |
| Hypoxia-Responsive CAR-T Cells Exhibit Reduced Exhaustion and Enhanced Efficacy in Solid Tumors. Zhu X, Chen J, Li W, Xu Y, Shan J, Hong J, Zhao Y, Xu H, Ma J, Shen J, Qian C. Cancer Res. 2024 Jan 2;84(1):84-100. doi: 10.1158/0008-5472.CAN-23-1038. PubMed |
| Tumor-repopulating cell-derived microparticles elicit cascade amplification of chemotherapy-induced antitumor immunity to boost anti-PD-1 therapy. Bie N, Yong T, Wei Z, Liang Q, Zhang X, Li S, Li X, Li J, Gan L, Yang X. Signal Transduct Target Ther. 2023 Oct 25;8(1):408. doi: 10.1038/s41392-023-01658-3. PubMed |
| ZSCAN4 interacts with PARP1 to promote DNA repair in mouse embryonic stem cells. Tsai LK, Peng M, Chang CC, Wen L, Liu L, Liang X, Chen YE, Xu J, Sung LY. Cell Biosci. 2023 Oct 24;13(1):193. doi: 10.1186/s13578-023-01140-1. PubMed |
| A SNAI2/CTCF Interaction is Required for NOTCH1 Expression in Rhabdomyosarcoma. Sreenivas P, Wang L, Wang M, Challa A, Modi P, Hensch NR, Gryder B, Chou HC, Zhao XR, Sunkel B, Moreno-Campos R, Khan J, Stanton BZ, Ignatius MS. Mol Cell Biol. 2023;43(11):547-565. doi: 10.1080/10985549.2023.2256640. Epub 2023 Nov 17. PubMed |
| The role of branched-chain aminotransferase 1 in driving glioblastoma cell proliferation and invasion varies with tumor subtype. Fala M, Ros S, Sawle A, Rao JU, Tsyben A, Tronci L, Frezza C, Mair R, Brindle KM. Neurooncol Adv. 2023 Sep 16;5(1):vdad120. doi: 10.1093/noajnl/vdad120. eCollection 2023 Jan-Dec. PubMed |
| capital ES, Cyrillicytotoxic effect of CAR-T cells against modified MCF-7 breast cancer cell line. Valiullina AK, Zmievskaya EA, Ganeeva IA, Zhuravleva MN, Garanina EE, Rizvanov AA, Petukhov AV, Bulatov ER. Mol Biol Res Commun. 2023;12(4):139-148. doi: 10.22099/mbrc.2023.47125.1820. PubMed |
| A novel pathogenic mutation of MeCP2 impairs chromatin association independent of protein levels. Zhou J, Cattoglio C, Shao Y, Tirumala HP, Vetralla C, Bajikar SS, Li Y, Chen H, Wang Q, Wu Z, Tang B, Zahabiyon M, Bajic A, Meng X, Ferrie JJ, LaGrone A, Zhang P, Kim JJ, Tang J, Liu Z, Darzacq X, Heintz N, Tjian R, Zoghbi HY. Genes Dev. 2023 Oct 1;37(19-20):883-900. doi: 10.1101/gad.350733.123. Epub 2023 Oct 27. PubMed |
NanoFIRE: A NanoLuciferase and Fluorescent Integrated Reporter Element for Robust and Sensitive Investigation of HIF and Other Signalling Pathways.
Roennfeldt AE, Allen TP, Trowbridge BN, Beard MR, Whitelaw ML, Russell DL, Bersten DC, Peet DJ.
Biomolecules. 2023 Oct 19;13(10):1545. doi: 10.3390/biom13101545.
PubMed
Associated Plasmids |
| Inactivation of Tumor Suppressor CYLD Inhibits Fibroblast Reprogramming to Pluripotency. Bekas N, Samiotaki M, Papathanasiou M, Mokos P, Pseftogas A, Xanthopoulos K, Thanos D, Mosialos G, Dafou D. Cancers (Basel). 2023 Oct 15;15(20):4997. doi: 10.3390/cancers15204997. PubMed |
| Human Non-Small Cell Lung Cancer-Chicken Embryo Chorioallantoic Membrane Tumor Models for Experimental Cancer Treatments. Li J, Brachtlova T, van der Meulen-Muileman IH, Kleerebezem S, Liu C, Li P, van Beusechem VW. Int J Mol Sci. 2023 Oct 21;24(20):15425. doi: 10.3390/ijms242015425. PubMed |
| Topoisomerase Inhibitors Increase Episomal DNA Expression by Inducing the Integration of Episomal DNA in Hepatic Cells. Gomez-Moreno A, San Sebastian E, Moya J, Gomollon-Zueco P, Isola S, Vales A, Gonzalez-Aseguinolaza G, Unzu C, Garaigorta U. Pharmaceutics. 2023 Oct 13;15(10):2459. doi: 10.3390/pharmaceutics15102459. PubMed |
| Amphipathic Cell-Penetrating Peptide-Aided Delivery of Cas9 RNP for In Vitro Gene Editing and Correction. Oktem M, Mastrobattista E, de Jong OG. Pharmaceutics. 2023 Oct 20;15(10):2500. doi: 10.3390/pharmaceutics15102500. PubMed |
| Exploring nutrient supplementation and bioprocess optimization to improve the production of lentiviral vectors in serum-free medium suspension cultures. Vaz TA, Rodrigues AF, Coroadinha AS. Biotechnol J. 2024 Jan;19(1):e2300212. doi: 10.1002/biot.202300212. Epub 2023 Nov 27. PubMed |
| AMPK activation induces immunogenic cell death in AML. Mondesir J, Ghisi M, Poillet L, Bossong RA, Kepp O, Kroemer G, Sarry JE, Tamburini J, Lane AA. Blood Adv. 2023 Dec 26;7(24):7585-7596. doi: 10.1182/bloodadvances.2022009444. PubMed |
| Landscape of enhancer disruption and functional screen in melanoma cells. Wang Z, Luo M, Liang Q, Zhao K, Hu Y, Wang W, Feng X, Hu B, Teng J, You T, Li R, Bao Z, Pan W, Yang T, Zhang C, Li T, Dong X, Yi X, Liu B, Zhao L, Li M, Chen K, Song W, Yang J, Li MJ. Genome Biol. 2023 Oct 30;24(1):248. doi: 10.1186/s13059-023-03087-5. PubMed |
| ONECUT2 Activates Diverse Resistance Drivers of Androgen Receptor-Independent Heterogeneity in Prostate Cancer. Qian C, Yang Q, Rotinen M, Huang R, Kim H, Gallent B, Yan Y, Cadaneanu RM, Zhang B, Kaochar S, Freedland SJ, Posadas EM, Ellis L, Vizio DD, Morrissey C, Nelson PS, Brady L, Murali R, Campbell MJ, Yang W, Knudsen BS, Mostaghel EA, Ye H, Garraway IP, You S, Freeman MR. bioRxiv [Preprint]. 2023 Oct 12:2023.09.28.560025. doi: 10.1101/2023.09.28.560025. PubMed |
| The Expression of LDL-R in CD8(+) T Cells Serves as an Early Assessment Parameter for the Production of TCR-T Cells. Wang YI, Hao YN, Shen MY, Han XJ, Wang YM, Chen SY, Wang JF, Wang W, Li TT, Jin AS. In Vivo. 2023 Nov-Dec;37(6):2480-2489. doi: 10.21873/invivo.13355. PubMed |
Targeting the non-coding genome and temozolomide signature enables CRISPR-mediated glioma oncolysis.
Tan IL, Perez AR, Lew RJ, Sun X, Baldwin A, Zhu YK, Shah MM, Berger MS, Doudna JA, Fellmann C.
Cell Rep. 2023 Nov 28;42(11):113339. doi: 10.1016/j.celrep.2023.113339. Epub 2023 Nov 2.
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Engineering a scalable and orthogonal platform for synthetic communication in mammalian cells.
Makri Pistikou AM, Cremers GAO, Nathalia BL, Meuleman TJ, Bogels BWA, Eijkens BV, de Dreu A, Bezembinder MTH, Stassen OMJA, Bouten CCV, Merkx M, Jerala R, de Greef TFA.
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| RGMa and Neogenin control dendritic spine morphogenesis via WAVE Regulatory Complex-mediated actin remodeling. Sempert K, Shohayeb B, Lanoue V, O'Brien EA, Flores C, Cooper HM. Front Mol Neurosci. 2023 Oct 19;16:1253801. doi: 10.3389/fnmol.2023.1253801. eCollection 2023. PubMed |
| ORAOV1, CCND1, and MIR548K Are the Driver Oncogenes of the 11q13 Amplicon in Squamous Cell Carcinoma. Mahieu CI, Mancini AG, Vikram EP, Planells-Palop V, Joseph NM, Tward AD. Mol Cancer Res. 2024 Feb 1;22(2):152-168. doi: 10.1158/1541-7786.MCR-23-0746. PubMed |
| The DNA-binding induced (de)AMPylation activity of a Coxiella burnetii Fic enzyme targets Histone H3. Hopfner D, Cichy A, Pogenberg V, Krisp C, Mezouar S, Bach NC, Grotheer J, Zarza SM, Martinez E, Bonazzi M, Feige MJ, Sieber SA, Schluter H, Itzen A. Commun Biol. 2023 Nov 6;6(1):1124. doi: 10.1038/s42003-023-05494-7. PubMed |
| Human amniotic membrane inhibits migration and invasion of muscle-invasive bladder cancer urothelial cells by downregulating the FAK/PI3K/Akt/mTOR signalling pathway. Janev A, Ramuta TZ, Jerman UD, Obradovic H, Kamensek U, Cemazar M, Kreft ME. Sci Rep. 2023 Nov 6;13(1):19227. doi: 10.1038/s41598-023-46091-2. PubMed |
| EZH2 inhibition stimulates repetitive element expression and viral mimicry in resting splenic B cells. Kim SJ, Kiser PK, Asfaha S, DeKoter RP, Dick FA. EMBO J. 2023 Dec 11;42(24):e114462. doi: 10.15252/embj.2023114462. Epub 2023 Nov 7. PubMed |
TEAD Inhibition Overcomes YAP1/TAZ-driven Primary and Acquired Resistance to KRASG12C Inhibitors.
Edwards AC, Stalnecker CA, Jean Morales A, Taylor KE, Klomp JE, Klomp JA, Waters AM, Sudhakar N, Hallin J, Tang TT, Olson P, Post L, Christensen JG, Cox AD, Der CJ.
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| Combining organotypic tissue culture with light-sheet microscopy (OTCxLSFM) to study glioma invasion. Haydo A, Wehle A, Herold-Mende C, Kogel D, Pampaloni F, Linder B. EMBO Rep. 2023 Dec 6;24(12):e56964. doi: 10.15252/embr.202356964. Epub 2023 Nov 8. PubMed |
| Checkpoint kinase 2 controls insulin secretion and glucose homeostasis. Chong ACN, Vandana JJ, Jeng G, Li G, Meng Z, Duan X, Zhang T, Qiu Y, Duran-Struuck R, Coker K, Wang W, Li Y, Min Z, Zuo X, de Silva N, Chen Z, Naji A, Hao M, Liu C, Chen S. Nat Chem Biol. 2023 Nov 9. doi: 10.1038/s41589-023-01466-4. PubMed |
| A combinatorial therapeutic approach to enhance FLT3-ITD AML treatment. Long J, Chen X, Shen Y, Lei Y, Mu L, Wang Z, Xiang R, Gao W, Wang L, Wang L, Jiang J, Zhang W, Lu H, Dong Y, Ding Y, Zhu H, Hong D, Sun YE, Hu J, Liang A. Cell Rep Med. 2023 Nov 21;4(11):101286. doi: 10.1016/j.xcrm.2023.101286. Epub 2023 Nov 10. PubMed |
| RACK1 promotes Shigella flexneri actin-mediated invasion, motility, and cell-to-cell spreading. Valenzuela-Valderas KN, Farrashzadeh E, Chang YY, Shi Y, Raudonis R, Leung BM, Rohde JR, Enninga J, Cheng Z. iScience. 2023 Oct 14;26(11):108216. doi: 10.1016/j.isci.2023.108216. eCollection 2023 Nov 17. PubMed |
| A complex with poly(A)-binding protein and EWS facilitates the transcriptional function of oncogenic ETS transcription factors in prostate cells. Greulich BM, Rajendran S, Downing NF, Nicholas TR, Hollenhorst PC. J Biol Chem. 2023 Dec;299(12):105453. doi: 10.1016/j.jbc.2023.105453. Epub 2023 Nov 11. PubMed |
| Molecular Determinants of Calcitriol Signaling and Sensitivity in Glioma Stem-like Cells. Rehbein S, Possmayer AL, Bozkurt S, Lotsch C, Gerstmeier J, Burger M, Momma S, Maletzki C, Classen CF, Freiman TM, Dubinski D, Lamszus K, Stringer BW, Herold-Mende C, Munch C, Kogel D, Linder B. Cancers (Basel). 2023 Oct 31;15(21):5249. doi: 10.3390/cancers15215249. PubMed |
| Decreased fucosylation impacts epithelial integrity and increases risk for COPD. Swaby C, Yeung-Luk B, Thapa S, Nishida K, Wally A, Ghosh B, Niederkofler A, Luk S, Girgis M, Keller A, Cortez C, Ramaswamy S, Wilmsen K, Bouche L, Dell A, Drummond MB, Putcha N, Haslam SM, Mathias R, Hansel NN, Sheng J, Sidhaye V. bioRxiv [Preprint]. 2023 Nov 2:2023.10.31.564805. doi: 10.1101/2023.10.31.564805. PubMed |
| Legionella pneumophila exploits the endo-lysosomal network for phagosome biogenesis by co-opting SUMOylated Rab7. Li C, Fu J, Shao S, Luo ZQ. bioRxiv [Preprint]. 2023 Oct 31:2023.10.31.564884. doi: 10.1101/2023.10.31.564884. PubMed |
| A partial human LCK defect causes a T cell immunodeficiency with intestinal inflammation. Lui VG, Hoenig M, Cabrera-Martinez B, Baxter RM, Garcia-Perez JE, Bailey O, Acharya A, Lundquist K, Capera J, Matusewicz P, Hartl FA, D'Abramo M, Alba J, Jacobsen EM, Niewolik D, Lorenz M, Pannicke U, Schulz AS, Debatin KM, Schamel WW, Minguet S, Gumbart JC, Dustin ML, Cambier JC, Schwarz K, Hsieh EWY. J Exp Med. 2024 Jan 1;221(1):e20230927. doi: 10.1084/jem.20230927. Epub 2023 Nov 14. PubMed |
| Super-enhancer driven SOX2 promotes tumor formation by chromatin re-organization in nasopharyngeal carcinoma. Liu SX, Wang C, Lin RB, Ding WY, Roy G, Wang HB, Yang T, Liu Q, Luo YL, Jin SL, Zeng MS, Zhao B, Zhong Q. EBioMedicine. 2023 Dec;98:104870. doi: 10.1016/j.ebiom.2023.104870. Epub 2023 Nov 14. PubMed |
| PAX3-FOXO1 dictates myogenic reprogramming and rhabdomyosarcoma identity in endothelial progenitors. Searcy MB, Larsen RK 4th, Stevens BT, Zhang Y, Jin H, Drummond CJ, Langdon CG, Gadek KE, Vuong K, Reed KB, Garcia MR, Xu B, Kimbrough DW, Adkins GE, Djekidel N, Porter SN, Schreiner PA, Pruett-Miller SM, Abraham BJ, Rehg JE, Hatley ME. Nat Commun. 2023 Nov 15;14(1):7291. doi: 10.1038/s41467-023-43044-1. PubMed |
| The CD2v protein of African swine fever virus inhibits macrophage migration and inflammatory cytokines expression by downregulating EGR1 expression through dampening ERK1/2 activity. Zhang M, Lv L, Luo H, Cai H, Yu L, Jiang Y, Gao F, Tong W, Li L, Li G, Zhou Y, Tong G, Liu C. Vet Res. 2023 Nov 15;54(1):106. doi: 10.1186/s13567-023-01239-w. PubMed |
| The long non-coding RNA OTX2-AS1 promotes tumor growth and predicts response to BCL-2 inhibition in medulloblastoma. Qin N, Paisana E, Picard D, Leprivier G, Langini M, Custodia C, Cascao R, Conrad C, Peitzsch M, Stefanski A, Stuhler K, Fischer U, Faria CC, Dietrich S, Reifenberger G, Remke M. J Neurooncol. 2023 Nov;165(2):329-342. doi: 10.1007/s11060-023-04508-y. Epub 2023 Nov 17. PubMed |
| Elevated 2-oxoglutarate antagonizes DNA damage responses in cholangiocarcinoma chemotherapy through regulating aspartate beta-hydroxylase. Nagaoka K, Bai X, Liu D, Cao K, Mulla J, Ji C, Chen H, Nisar MA, Bay A, Mueller W, Hildebrand G, Gao JS, Lu S, Setoyama H, Tanaka Y, Wands JR, Huang CK. Cancer Lett. 2024 Jan 1;580:216493. doi: 10.1016/j.canlet.2023.216493. Epub 2023 Nov 15. PubMed |
| Cell-type-specific need of Ddx3 and PACT for interferon induction by RNA viruses. Sharma N, Kessler P, Sen GC. J Virol. 2023 Dec 21;97(12):e0130423. doi: 10.1128/jvi.01304-23. Epub 2023 Nov 20. PubMed |
| Direct and biologically significant interactions of human herpesvirus 8 interferon regulatory factor 1 with STAT3 and Janus kinase TYK2. Yang Z, Xiang Q, Nicholas J. PLoS Pathog. 2023 Nov 20;19(11):e1011806. doi: 10.1371/journal.ppat.1011806. eCollection 2023 Nov. PubMed |
Third-generation rabies viral vectors allow nontoxic retrograde targeting of projection neurons with greatly increased efficiency.
Jin L, Sullivan HA, Zhu M, Lea NE, Lavin TK, Fu X, Matsuyama M, Hou Y, Feng G, Wickersham IR.
Cell Rep Methods. 2023 Nov 20;3(11):100644. doi: 10.1016/j.crmeth.2023.100644.
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| PRMT1 Inhibition Activates the Interferon Pathway to Potentiate Antitumor Immunity and Enhance Checkpoint Blockade Efficacy in Melanoma. Tao H, Jin C, Zhou L, Deng Z, Li X, Dang W, Fan S, Li B, Ye F, Lu J, Kong X, Liu C, Luo C, Zhang Y. Cancer Res. 2024 Feb 1;84(3):419-433. doi: 10.1158/0008-5472.CAN-23-1082. PubMed |
| ELOA3: A primate-specific RNA polymerase II elongation factor encoded by a tandem repeat gene cluster. Morgan MAJ, Mohammad Parast S, Iwanaszko M, Aoi Y, Yoo D, Dumar ZJ, Howard BC, Helmin KA, Liu Q, Thakur WR, Zeidner JM, Singer BD, Eichler EE, Shilatifard A. Sci Adv. 2023 Nov 24;9(47):eadj1261. doi: 10.1126/sciadv.adj1261. Epub 2023 Nov 22. PubMed |
| Retrovirus-like gag protein Arc/Arg3.1 is involved in extracellular-vesicle-mediated mRNA transfer between glioma cells. Al Othman A, Bagrov D, Rozenberg JM, Glazova O, Skryabin G, Tchevkina E, Mezentsev A, Durymanov M. Biochim Biophys Acta Gen Subj. 2024 Jan;1868(1):130522. doi: 10.1016/j.bbagen.2023.130522. Epub 2023 Nov 22. PubMed |
BioE3 identifies specific substrates of ubiquitin E3 ligases.
Barroso-Gomila O, Merino-Cacho L, Muratore V, Perez C, Taibi V, Maspero E, Azkargorta M, Iloro I, Trulsson F, Vertegaal ACO, Mayor U, Elortza F, Polo S, Barrio R, Sutherland JD.
Nat Commun. 2023 Nov 23;14(1):7656. doi: 10.1038/s41467-023-43326-8.
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| Genomic analysis reveals HDAC1 regulates clinically relevant transcriptional programs in Pancreatic cancer. Wright CA, Gordon ER, Cooper SJ. BMC Cancer. 2023 Nov 23;23(1):1137. doi: 10.1186/s12885-023-11645-0. PubMed |
| Sphingolipid-Based Synergistic Interactions to Enhance Chemosensitivity in Lung Cancer Cells. Mesen-Porras S, Rojas-Cespedes A, Molina-Mora JA, Vega-Baudrit J, Siles F, Quiros S, Mora-Rodriguez R. Cells. 2023 Nov 8;12(22):2588. doi: 10.3390/cells12222588. PubMed |
| Unraveling the Mechanisms of Sensitivity to Anti-FGF Therapies in Imatinib-Resistant Gastrointestinal Stromal Tumors (GIST) Lacking Secondary KIT Mutations. Boichuk S, Dunaev P, Skripova V, Galembikova A, Bikinieva F, Shagimardanova E, Gazizova G, Deviatiiarov R, Valeeva E, Mikheeva E, Vasilyeva M, Kopnin P, Strelnikov V, Kiyamova R. Cancers (Basel). 2023 Nov 9;15(22):5354. doi: 10.3390/cancers15225354. PubMed |
| The m(7)G Reader NCBP2 Promotes Pancreatic Cancer Progression by Upregulating MAPK/ERK Signaling. Xie J, Mo T, Li R, Zhang H, Liang G, Ma T, Chen J, Xie H, Wen X, Hu T, Xian Z, Pan W. Cancers (Basel). 2023 Nov 17;15(22):5454. doi: 10.3390/cancers15225454. PubMed |
| Revealing Pan-Histology Immunomodulatory Targets in Pediatric Central Nervous System Tumors. Galvin RT, Jena S, Maeser D, Gruener R, Huang RS. Cancers (Basel). 2023 Nov 17;15(22):5455. doi: 10.3390/cancers15225455. PubMed |
| Functional engineering of human iPSC-derived parasympathetic neurons enhances responsiveness to gastrointestinal hormones. Akagi Y, Takayama Y, Nihashi Y, Yamashita A, Yoshida R, Miyamoto Y, Kida YS. FEBS Open Bio. 2024 Jan;14(1):63-78. doi: 10.1002/2211-5463.13741. Epub 2023 Dec 12. PubMed |
| Prior Fc Receptor activation primes macrophages for increased sensitivity to IgG via long term and short term mechanisms. Bond A, Fiaz S, Rollins KR, Nario JEQ, Rosen SJ, Granados A, Wilson MZ, Morrissey MA. bioRxiv [Preprint]. 2023 Nov 14:2023.11.14.567059. doi: 10.1101/2023.11.14.567059. PubMed |
| The ELAVL3/MYCN positive feedback loop provides a therapeutic target for neuroendocrine prostate cancer. Ji Y, Zhang W, Shen K, Su R, Liu X, Ma Z, Liu B, Hu C, Xue Y, Xin Z, Yang Y, Li A, Jiang Z, Jing N, Zhu HH, Dong L, Zhu Y, Dong B, Pan J, Wang Q, Xue W. Nat Commun. 2023 Nov 28;14(1):7794. doi: 10.1038/s41467-023-43676-3. PubMed |
| hnRNPA2B1 promotes the occurrence and progression of hepatocellular carcinoma by downregulating PCK1 mRNA via a m6A RNA methylation manner. Hao W, Chen Z, Tang J, Yang R, Gao WQ, Xu H. J Transl Med. 2023 Nov 28;21(1):861. doi: 10.1186/s12967-023-04704-4. PubMed |
| Small-molecule correctors divert CFTR-F508del from ERAD by stabilizing sequential folding states. Riepe C, Wachalska M, Deol KK, Amaya AK, Porteus MH, Olzmann JA, Kopito RR. Mol Biol Cell. 2024 Feb 1;35(2):ar15. doi: 10.1091/mbc.E23-08-0336. Epub 2023 Nov 29. PubMed |
| Leucine-rich repeat kinase 2 (LRRK2) inhibition upregulates microtubule-associated protein 1B to ameliorate lysosomal dysfunction and parkinsonism. Chen K, Tang F, Du B, Yue ZZ, Jiao LL, Ding XL, Tuo QZ, Meng J, He SY, Dai L, Lei P, Wei XW. MedComm (2020). 2023 Nov 20;4(6):e429. doi: 10.1002/mco2.429. eCollection 2023 Dec. PubMed |
| Illuminating the mechanism and allosteric behavior of NanoLuc luciferase. Nemergut M, Pluskal D, Horackova J, Sustrova T, Tulis J, Barta T, Baatallah R, Gagnot G, Novakova V, Majerova M, Sedlackova K, Marques SM, Toul M, Damborsky J, Prokop Z, Bednar D, Janin YL, Marek M. Nat Commun. 2023 Nov 29;14(1):7864. doi: 10.1038/s41467-023-43403-y. PubMed |
| Discovery of a Drug-like, Natural Product-Inspired DCAF11 Ligand Chemotype. Xue G, Xie J, Hinterndorfer M, Cigler M, Dotsch L, Imrichova H, Lampe P, Cheng X, Adariani SR, Winter GE, Waldmann H. Nat Commun. 2023 Nov 30;14(1):7908. doi: 10.1038/s41467-023-43657-6. PubMed |
| The subset of peroxisomal tail-anchored proteins do not reach peroxisomes via ER, instead mitochondria can be involved. Somborac T, Lutfullahoglu Bal G, Fatima K, Vihinen H, Paatero A, Jokitalo E, Paavilainen VO, Konovalova S. PLoS One. 2023 Dec 1;18(12):e0295047. doi: 10.1371/journal.pone.0295047. eCollection 2023. PubMed |
| RNA binding proteins PTBP1 and HNRNPL regulate CFTR mRNA decay. Siddiqui A, Saxena A, Echols J, Havasi V, Fu L, Keeling KM. Heliyon. 2023 Nov 13;9(11):e22281. doi: 10.1016/j.heliyon.2023.e22281. eCollection 2023 Nov. PubMed |
| Enhancer regulatory networks globally connect non-coding breast cancer loci to cancer genes. Wang Y, Armendariz D, Wang L, Zhao H, Xie S, Hon GC. bioRxiv [Preprint]. 2023 Nov 20:2023.11.20.567880. doi: 10.1101/2023.11.20.567880. PubMed |
Structural and mechanistic insights into disease-associated endolysosomal exonucleases PLD3 and PLD4.
Yuan M, Peng L, Huang D, Gavin A, Luan F, Tran J, Feng Z, Zhu X, Matteson J, Wilson IA, Nemazee D.
Structure. 2024 Jun 6;32(6):766-779.e7. doi: 10.1016/j.str.2024.02.019. Epub 2024 Mar 26.
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| The glycoprotein 5 of porcine reproductive and respiratory syndrome virus stimulates mitochondrial ROS to facilitate viral replication. Zhang S, Zeng L, Su B-Q, Yang G-Y, Wang J, Ming S-L, Chu B-B. mBio. 2023 Dec 4;14(6):e0265123. doi: 10.1128/mbio.02651-23. PubMed |
| Epidermal growth factor potentiates EGFR(Y992/1173)-mediated therapeutic response of triple negative breast cancer cells to cold atmospheric plasma-activated medium. Wang P, Zhou R, Zhou R, Feng S, Zhao L, Li W, Lin J, Rajapakse A, Lee CH, Furnari FB, Burgess AW, Gunter JH, Liu G, Ostrikov KK, Richard DJ, Simpson F, Dai X, Thompson EW. Redox Biol. 2024 Feb;69:102976. doi: 10.1016/j.redox.2023.102976. Epub 2023 Nov 29. PubMed |
| Leukemia-intrinsic determinants of CAR-T response revealed by iterative in vivo genome-wide CRISPR screening. Ramos A, Koch CE, Liu-Lupo Y, Hellinger RD, Kyung T, Abbott KL, Frose J, Goulet D, Gordon KS, Eidell KP, Leclerc P, Whittaker CA, Larson RC, Muscato AJ, Yates KB, Dubrot J, Doench JG, Regev A, Vander Heiden MG, Maus MV, Manguso RT, Birnbaum ME, Hemann MT. Nat Commun. 2023 Dec 5;14(1):8048. doi: 10.1038/s41467-023-43790-2. PubMed |
| RAD54L2 counters TOP2-DNA adducts to promote genome stability. D'Alessandro G, Morales-Juarez DA, Richards SL, Nitiss KC, Serrano-Benitez A, Wang J, Thomas JC, Gupta V, Voigt A, Belotserkovskaya R, Goh CG, Bowden AR, Galanty Y, Beli P, Nitiss JL, Zagnoli-Vieira G, Jackson SP. Sci Adv. 2023 Dec 8;9(49):eadl2108. doi: 10.1126/sciadv.adl2108. Epub 2023 Dec 6. PubMed |
| Risk model-guided identification of MTDH expression as a marker for ferroptosis induction therapy in head and neck squamous cell carcinoma. Wang X, Gao Y, Miao R, Li L, Nanding A, Liu Y, Zhang X. Am J Cancer Res. 2023 Nov 15;13(11):5236-5253. eCollection 2023. PubMed |
| Epstein-Barr virus induces germinal center light zone chromatin architecture and promotes survival through enhancer looping at the BCL2A1 locus. Dai J, SoRelle ED, Heckenberg E, Song L, Cable JM, Crawford GE, Luftig MA. mBio. 2024 Jan 16;15(1):e0244423. doi: 10.1128/mbio.02444-23. Epub 2023 Dec 7. PubMed |
| BRD4 binds to active cranial neural crest enhancers to regulate RUNX2 activity during osteoblast differentiation. Musa RE, Lester KL, Quickstad G, Vardabasso S, Shumate TV, Salcido RT, Ge K, Shpargel KB. Development. 2024 Jan 15;151(2):dev202110. doi: 10.1242/dev.202110. Epub 2024 Jan 24. PubMed |
| Pediatric glioma histone H3.3 K27M/G34R mutations drive abnormalities in PML nuclear bodies. Voon HPJ, Hii L, Garvie A, Udugama M, Krug B, Russo C, Chueh AC, Daly RJ, Morey A, Bell TDM, Turner SJ, Rosenbluh J, Daniel P, Firestein R, Mann JR, Collas P, Jabado N, Wong LH. Genome Biol. 2023 Dec 8;24(1):284. doi: 10.1186/s13059-023-03122-5. PubMed |
| Sex and Age Impact CD4+ T Cell Susceptibility to HIV In Vitro through Cell Activation Dynamics. Brandt L, Angelino P, Martinez R, Cristinelli S, Ciuffi A. Cells. 2023 Nov 23;12(23):2689. doi: 10.3390/cells12232689. PubMed |
| AA2P-mediated DNA demethylation synergizes with stem cell agonists to promote expansion of hematopoietic stem cells. Manesia JK, Maganti HB, Almoflehi S, Jahan S, Hasan T, Pasha R, McGregor C, Dumont N, Laganiere J, Audet J, Pineault N. Cell Rep Methods. 2023 Dec 18;3(12):100663. doi: 10.1016/j.crmeth.2023.100663. Epub 2023 Dec 8. PubMed |
| RAAS-deficient organoids indicate delayed angiogenesis as a possible cause for autosomal recessive renal tubular dysgenesis. Pode-Shakked N, Slack M, Sundaram N, Schreiber R, McCracken KW, Dekel B, Helmrath M, Kopan R. Nat Commun. 2023 Dec 9;14(1):8159. doi: 10.1038/s41467-023-43795-x. PubMed |
| A high-throughput two-cell assay for interrogating inhibitory signaling pathways in T cells. Sharma S, Whitehead T, Kotowski M, Ng EZQ, Clarke J, Leitner J, Chen YL, Santos AM, Steinberger P, Davis SJ. Life Sci Alliance. 2023 Dec 7;7(3):e202302359. doi: 10.26508/lsa.202302359. Print 2024 Mar. PubMed |
| The formation of ubiquitin rich condensates triggers recruitment of the ATG9A lipid transfer complex to initiate basal autophagy. Broadbent DG, McEwan CM, Tsang TM, Poole DM, Naylor BC, Price JC, Schmidt JC, Andersen JL. bioRxiv [Preprint]. 2023 Nov 29:2023.11.28.569058. doi: 10.1101/2023.11.28.569058. PubMed |
| GRAF1 integrates PINK1-Parkin signaling and actin dynamics to mediate cardiac mitochondrial homeostasis. Zhu Q, Combs ME, Liu J, Bai X, Wang WB, Herring LE, Liu J, Locasale JW, Bowles DE, Gross RT, Pla MM, Mack CP, Taylor JM. Nat Commun. 2023 Dec 11;14(1):8187. doi: 10.1038/s41467-023-43889-6. PubMed |
| Efficient gene editing in induced pluripotent stem cells enabled by an inducible adenine base editor with tunable expression. Nandy K, Babu D, Rani S, Joshi G, Ijee S, George A, Palani D, Premkumar C, Rajesh P, Vijayanand S, David E, Murugesan M, Velayudhan SR. Sci Rep. 2023 Dec 11;13(1):21953. doi: 10.1038/s41598-023-42174-2. PubMed |
| Transition of allele-specific DNA hydroxymethylation at regulatory loci is associated with phenotypic variation in monozygotic twins discordant for psychiatric disorders. Ye J, Huang Z, Li Q, Li Z, Lan Y, Wang Z, Ni C, Wu X, Jiang T, Li Y, Yang Q, Lim J, Ren CY, Jiang M, Li S, Jin P, Chen JH, Zhao C. BMC Med. 2023 Dec 12;21(1):491. doi: 10.1186/s12916-023-03177-y. PubMed |
Proximity proteomic analysis of the NRF family reveals the Parkinson's disease protein ZNF746/PARIS as a co-complexed repressor of NRF2.
LaPak KM, Saeidi S, Bok I, Wamsley NT, Plutzer IB, Bhatt DP, Luo J, Ashrafi G, Ben Major M.
Sci Signal. 2023 Dec 12;16(815):eadi9018. doi: 10.1126/scisignal.adi9018. Epub 2023 Dec 12.
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Cell type directed design of synthetic enhancers.
Taskiran II, Spanier KI, Dickmanken H, Kempynck N, Pancikova A, Eksi EC, Hulselmans G, Ismail JN, Theunis K, Vandepoel R, Christiaens V, Mauduit D, Aerts S.
Nature. 2023 Dec 12. doi: 10.1038/s41586-023-06936-2.
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Associated Plasmids |
| Single-Cell Transcriptomics Reveals the Heterogeneity of the Immune Landscape of IDH-Wild-Type High-Grade Gliomas. Ran X, Zheng J, Chen L, Xia Z, Wang Y, Sun C, Guo C, Lin P, Liu F, Wang C, Zhou J, Sun C, Liu Q, Ma J, Qin Z, Zhu X, Xie Q. Cancer Immunol Res. 2024 Feb 2;12(2):232-246. doi: 10.1158/2326-6066.CIR-23-0211. PubMed |
Base-editing mutagenesis maps alleles to tune human T cell functions.
Schmidt R, Ward CC, Dajani R, Armour-Garb Z, Ota M, Allain V, Hernandez R, Layeghi M, Xing G, Goudy L, Dorovskyi D, Wang C, Chen YY, Ye CJ, Shy BR, Gilbert LA, Eyquem J, Pritchard JK, Dodgson SE, Marson A.
Nature. 2024 Jan;625(7996):805-812. doi: 10.1038/s41586-023-06835-6. Epub 2023 Dec 13.
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Associated Plasmids |
| USP13 drives lung squamous cell carcinoma by switching lung club cell lineage plasticity. Kwon J, Zhang J, Mok B, Allsup S, Kim C, Toretsky J, Han C. Mol Cancer. 2023 Dec 13;22(1):204. doi: 10.1186/s12943-023-01892-x. PubMed |
Molecular basis and cellular functions of vinculin-actin directional catch bonding.
Chirasani VR, Khan MAI, Malavade JN, Dokholyan NV, Hoffman BD, Campbell SL.
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| PAX3-FOXO1 uses its activation domain to recruit CBP/P300 and shape RNA Pol2 cluster distribution. Asante Y, Benischke K, Osman I, Ngo QA, Wurth J, Laubscher D, Kim H, Udhayakumar B, Khan MIH, Chin DH, Porch J, Chakraborty M, Sallari R, Delattre O, Zaidi S, Morice S, Surdez D, Danielli SG, Schafer BW, Gryder BE, Wachtel M. Nat Commun. 2023 Dec 15;14(1):8361. doi: 10.1038/s41467-023-43780-4. PubMed |
| Microtubule-dependent apical polarization of basement membrane matrix mRNAs in mouse epithelial cells. Wang S, Matsumoto K, Mehlferber MM, Zhang G, Aronova MA, Yamada KM. Cells Dev. 2023 Dec 14;177:203898. doi: 10.1016/j.cdev.2023.203898. PubMed |
| RAPIDASH: A tag-free enrichment of ribosome-associated proteins reveals compositional dynamics in embryonic tissues and stimulated macrophages. Susanto TT, Hung V, Levine AG, Kerr CH, Yoo Y, Chen Y, Oses-Prieto JA, Fromm L, Fujii K, Wernig M, Burlingame AL, Ruggero D, Barna M. bioRxiv [Preprint]. 2023 Dec 7:2023.12.07.570613. doi: 10.1101/2023.12.07.570613. PubMed |
| Stimulation Strength Determined by Superantigen Dose Controls Subcellular Localization of FOXP3 Isoforms and Suppressive Function of CD4+CD25+FOXP3+ T Cells. Lee J, Park N, Nicosia M, Park JY, Pruett SB, Seo KS. J Immunol. 2024 Feb 1;212(3):421-432. doi: 10.4049/jimmunol.2300019. PubMed |
| Engrailed-1 Promotes Pancreatic Cancer Metastasis. Xu J, Roe JS, Lee E, Tonelli C, Ji KY, Younis OW, Somervile TDD, Yao M, Milazzo JP, Tiriac H, Kolarzyk AM, Lee E, Grem JL, Lazenby AJ, Grunkemeyer JA, Hollingsworth MA, Grandgenett PM, Borowsky AD, Park Y, Vakoc CR, Tuveson DA, Hwang CI. Adv Sci (Weinh). 2024 Feb;11(6):e2308537. doi: 10.1002/advs.202308537. Epub 2023 Dec 18. PubMed |
| High-throughput deconvolution of 3D organoid dynamics at cellular resolution for cancer pharmacology with Cellos. Mukashyaka P, Kumar P, Mellert DJ, Nicholas S, Noorbakhsh J, Brugiolo M, Courtois ET, Anczukow O, Liu ET, Chuang JH. Nat Commun. 2023 Dec 18;14(1):8406. doi: 10.1038/s41467-023-44162-6. PubMed |
| Non-canonical Hedgehog signaling mediates profibrotic hematopoiesis-stroma crosstalk in myeloproliferative neoplasms. Pritchard JE, Pearce JE, Snoeren IAM, Fuchs SNR, Gotz K, Peisker F, Wagner S, Benabid A, Lutterbach N, Kloker V, Nagai JS, Hannani MT, Galyga AK, Sistemich E, Banjanin B, Flosdorf N, Bindels E, Olschok K, Biaesch K, Chatain N, Bhagwat N, Dunbar A, Sarkis R, Naveiras O, Berres ML, Koschmieder S, Levine RL, Costa IG, Gleitz HFE, Kramann R, Schneider RK. Cell Rep. 2024 Jan 23;43(1):113608. doi: 10.1016/j.celrep.2023.113608. Epub 2023 Dec 20. PubMed |
| Neuronal-type-specific epigenome editing to decrease SNCA expression: Implications for precision medicine in synucleinopathies. Sun Z, Kantor B, Chiba-Falek O. Mol Ther Nucleic Acids. 2023 Nov 24;35(1):102084. doi: 10.1016/j.omtn.2023.102084. eCollection 2024 Mar 12. PubMed |
| Chromosome 8p engineering reveals increased metastatic potential targetable by patient-specific synthetic lethality in liver cancer. Huth T, Dreher EC, Lemke S, Fritzsche S, Sugiyanto RN, Castven D, Ibberson D, Sticht C, Eiteneuer E, Jauch A, Pusch S, Albrecht T, Goeppert B, Candia J, Wang XW, Ji J, Marquardt JU, Nahnsen S, Schirmacher P, Roessler S. Sci Adv. 2023 Dec 22;9(51):eadh1442. doi: 10.1126/sciadv.adh1442. Epub 2023 Dec 22. PubMed |
| Altered Treg Infiltration after Discoidin Domain Receptor 1 (DDR1) Inhibition and Knockout Promotes Tumor Growth in Lung Adenocarcinoma. Maitz K, Valadez-Cosmes P, Raftopoulou S, Kindler O, Kienzl M, Bolouri H, Houghton AM, Schicho R, Heinemann A, Kargl J. Cancers (Basel). 2023 Dec 8;15(24):5767. doi: 10.3390/cancers15245767. PubMed |
| A versatile method for the identification of senolytic compounds. Annunziata C, Castoldi F, Jan S, Ang HX, Ristovska M, Melini S, Welch R, Riedel CG, Pietrocola F. Cell Stress. 2023 Dec 11;7(12):105-111. doi: 10.15698/cst2023.12.292. eCollection 2023 Dec. PubMed |
hRpn13 shapes the proteome and transcriptome through epigenetic factors HDAC8, PADI4, and transcription factor NF-kappaB p50.
Osei-Amponsa V, Chandravanshi M, Lu X, Magidson V, Das S, Andresson T, Dyba M, Sabbasani VR, Swenson RE, Fromont C, Shrestha B, Zhao Y, Clapp ME, Chari R, Walters KJ.
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| An impaired ubiquitin-proteasome system increases APOBEC3A abundance. Coxon M, Dennis MA, Dananberg A, Collins CD, Wilson HE, Meekma J, Savenkova MI, Ng D, Osbron CA, Mertz TM, Goodman AG, Duttke SH, Maciejowski J, Roberts SA. NAR Cancer. 2023 Dec 19;5(4):zcad058. doi: 10.1093/narcan/zcad058. eCollection 2023 Dec. PubMed |
| Endothelial Jagged1 levels and distribution are post-transcriptionally controlled by ZFP36 decay proteins. Sunshine HL, Cicchetto AC, Kaczor-Urbanowicz KE, Ma F, Pi D, Symons C, Turner M, Shukla V, Christofk HR, Vallim TA, Iruela-Arispe ML. Cell Rep. 2024 Jan 23;43(1):113627. doi: 10.1016/j.celrep.2023.113627. Epub 2023 Dec 28. PubMed |
| Impact of eIF2alpha phosphorylation on the translational landscape of mouse embryonic stem cells. Amiri M, Kiniry SJ, Possemato AP, Mahmood N, Basiri T, Dufour CR, Tabatabaei N, Deng Q, Bellucci MA, Harwalkar K, Stokes MP, Giguere V, Kaufman RJ, Yamanaka Y, Baranov PV, Tahmasebi S, Sonenberg N. Cell Rep. 2024 Jan 23;43(1):113615. doi: 10.1016/j.celrep.2023.113615. Epub 2023 Dec 29. PubMed |
| A novel iPSC model reveals selective vulnerability of neurons in multiple sulfatase deficiency. Pham V, Sertori Finoti L, Cassidy MM, Maguire JA, Gagne AL, Waxman EA, French DL, King K, Zhou Z, Gelb MH, Wongkittichote P, Hong X, Schlotawa L, Davidson BL, Ahrens-Nicklas RC. Mol Genet Metab. 2024 Feb;141(2):108116. doi: 10.1016/j.ymgme.2023.108116. Epub 2023 Dec 21. PubMed |
| Carcinogenic Role and Clinical Significance of Histone H3-H4 Chaperone Anti-silencing Function 1 B (ASF1B) in Lung Adenocarcinoma. Song C, Song Y, Wan X, Zhao Z, Geng Q. J Cancer. 2024 Jan 1;15(1):218-231. doi: 10.7150/jca.88777. eCollection 2024. PubMed |
| ARID1A deficiency promotes progression and potentiates therapeutic antitumour immunity in hepatitis B virus-related hepatocellular carcinoma. Xing T, Li L, Rao X, Zhao J, Chen Y, Ju G, Xu Y, Gao X, Dong G, Xia X, Guan Y, Zhang L, Wen Z, Liang J. BMC Gastroenterol. 2024 Jan 2;24(1):11. doi: 10.1186/s12876-023-03059-w. PubMed |
| Pharmaceutical targeting of OTUB2 sensitizes tumors to cytotoxic T cells via degradation of PD-L1. Ren W, Xu Z, Chang Y, Ju F, Wu H, Liang Z, Zhao M, Wang N, Lin Y, Xu C, Chen S, Rao Y, Lin C, Yang J, Liu P, Zhang J, Huang C, Xia N. Nat Commun. 2024 Jan 2;15(1):9. doi: 10.1038/s41467-023-44466-7. PubMed |
| Mcam inhibits macrophage-mediated development of mammary gland through non-canonical Wnt signaling. Yang X, Xu H, Yang X, Wang H, Zou L, Yang Q, Qi X, Li L, Duan H, Yan X, Fu NY, Tan J, Hou Z, Jiao B. Nat Commun. 2024 Jan 2;15(1):36. doi: 10.1038/s41467-023-44338-0. PubMed |
| Tubeimosides are pan-coronavirus and filovirus inhibitors that can block their fusion protein binding to Niemann-Pick C1. Khan I, Li S, Tao L, Wang C, Ye B, Li H, Liu X, Ahmad I, Su W, Zhong G, Wen Z, Wang J, Hua RH, Ma A, Liang J, Wan XP, Bu ZG, Zheng YH. Nat Commun. 2024 Jan 2;15(1):162. doi: 10.1038/s41467-023-44504-4. PubMed |
| Direct effects of adipocyte lipolysis on AMPK through intracellular long-chain acyl-CoA signaling. Rahman AA, Butcko AJ, Songyekutu E, Granneman JG, Mottillo EP. Sci Rep. 2024 Jan 2;14(1):19. doi: 10.1038/s41598-023-50903-w. PubMed |
| Surplus fatty acid synthesis increases oxidative stress in adipocytes and lnduces lipodystrophy. Weng L, Tang WS, Wang X, Gong Y, Liu C, Hong NN, Tao Y, Li KZ, Liu SN, Jiang W, Li Y, Yao K, Chen L, Huang H, Zhao YZ, Hu ZP, Lu Y, Ye H, Du X, Zhou H, Li P, Zhao TJ. Nat Commun. 2024 Jan 2;15(1):133. doi: 10.1038/s41467-023-44393-7. PubMed |
| GSK3 inhibition reduces ECM production and prevents age-related macular degeneration-like pathology. DiCesare SM, Ortega AJ, Collier GE, Daniel S, Thompson KN, McCoy MK, Posner BA, Hulleman JD. bioRxiv [Preprint]. 2023 Dec 15:2023.12.14.571757. doi: 10.1101/2023.12.14.571757. PubMed |
| Host E3 ubiquitin ligase ITCH mediates Toxoplasma gondii effector GRA35-triggered NLRP1 inflammasome activation and cell-autonomous immunity. Wang Y, Hollingsworth LR, Sangare LO, Paredes-Santos TC, Krishnamurthy S, Penn BH, Wu H, Saeij JPJ. bioRxiv [Preprint]. 2023 Dec 14:2023.12.13.571530. doi: 10.1101/2023.12.13.571530. PubMed |
Large-scale evaluation of the ability of RNA-binding proteins to activate exon inclusion.
Schmok JC, Jain M, Street LA, Tankka AT, Schafer D, Her HL, Elmsaouri S, Gosztyla ML, Boyle EA, Jagannatha P, Luo EC, Kwon EJ, Jovanovic M, Yeo GW.
Nat Biotechnol. 2024 Jan 2. doi: 10.1038/s41587-023-02014-0.
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| Ultrafast bisulfite sequencing detection of 5-methylcytosine in DNA and RNA. Dai Q, Ye C, Irkliyenko I, Wang Y, Sun HL, Gao Y, Liu Y, Beadell A, Perea J, Goel A, He C. Nat Biotechnol. 2024 Jan 2. doi: 10.1038/s41587-023-02034-w. PubMed |
| N-acetyltransferase 10 regulates alphavirus replication via N4-acetylcytidine (ac4C) modi fi cation of the lymphocyte antigen six family member E (LY6E) mRNA. Dang Y, Li J, Li Y, Wang Y, Zhao Y, Zhao N, Li W, Zhang H, Ye C, Ma H, Zhang L, Liu H, Dong Y, Yao M, Lei Y, Xu Z, Zhang F, Ye W. J Virol. 2024 Jan 23;98(1):e0135023. doi: 10.1128/jvi.01350-23. Epub 2024 Jan 3. PubMed |
| Cyclical palmitoylation regulates TLR9 signalling and systemic autoimmunity in mice. Ni H, Wang Y, Yao K, Wang L, Huang J, Xiao Y, Chen H, Liu B, Yang CY, Zhao J. Nat Commun. 2024 Jan 2;15(1):1. doi: 10.1038/s41467-023-43650-z. PubMed |
| Pharmacological inhibition of MYC to mitigate chemoresistance in preclinical models of squamous cell carcinoma. Liu S, Qin Z, Mao Y, Wang N, Zhang W, Wang Y, Chen Y, Jia L, Peng X. Theranostics. 2024 Jan 1;14(2):622-639. doi: 10.7150/thno.88759. eCollection 2024. PubMed |
| Transcriptional determinants of lipid mobilization in human adipocytes. Ludzki AC, Hansen M, Zareifi D, Jalkanen J, Huang Z, Omar-Hmeadi M, Renzi G, Klingelhuber F, Boland S, Ambaw YA, Wang N, Damdimopoulos A, Liu J, Jernberg T, Petrus P, Arner P, Krahmer N, Fan R, Treuter E, Gao H, Ryden M, Mejhert N. Sci Adv. 2024 Jan 5;10(1):eadi2689. doi: 10.1126/sciadv.adi2689. Epub 2024 Jan 3. PubMed |
| The low-density lipoprotein receptor promotes infection of multiple encephalitic alphaviruses. Ma H, Adams LJ, Raju S, Sariol A, Kafai NM, Janova H, Klimstra WB, Fremont DH, Diamond MS. Nat Commun. 2024 Jan 4;15(1):246. doi: 10.1038/s41467-023-44624-x. PubMed |
| Acellular scaffold-based approach for in situ genetic engineering of host T-cells in solid tumor immunotherapy. Dandia HY, Pillai MM, Sharma D, Suvarna M, Dalal N, Madhok A, Ingle A, Chiplunkar SV, Galande S, Tayalia P. Mil Med Res. 2024 Jan 4;11(1):3. doi: 10.1186/s40779-023-00503-6. PubMed |
| KDM5B predicts temozolomide-resistant subclones in glioblastoma. Ullrich V, Ertmer S, Baginska A, Dorsch M, Gull HH, Cima I, Berger P, Dobersalske C, Langer S, Meyer L, Dujardin P, Kebir S, Glas M, Blau T, Keyvani K, Rauschenbach L, Sure U, Roesch A, Gruner BM, Scheffler B. iScience. 2023 Dec 3;27(1):108596. doi: 10.1016/j.isci.2023.108596. eCollection 2024 Jan 19. PubMed |
| Hepatitis C virus E1 recruits high-density lipoprotein to support infectivity and evade antibody recognition. Casiano Matos J, Harichandran K, Tang J, Sviridov DO, Sidoti Migliore G, Suzuki M, Olano LR, Hobbs A, Kumar A, Paskel MU, Bonsignori M, Dearborn AD, Remaley AT, Marcotrigiano J. J Virol. 2024 Jan 23;98(1):e0084923. doi: 10.1128/jvi.00849-23. Epub 2024 Jan 4. PubMed |
| Targeting cancer-associated fibroblast autophagy renders pancreatic cancer eradicable with immunochemotherapy by inhibiting adaptive immune resistance. Zhang X, Lao M, Yang H, Sun K, Dong Y, He L, Jiang X, Wu H, Jiang Y, Li M, Ying H, Liu X, Xu J, Chen Y, Zhang H, Zhou R, Gao J, Bai X, Liang T. Autophagy. 2024 Jan 4:1-21. doi: 10.1080/15548627.2023.2300913. PubMed |
| Nuclear membrane protein SUN2 promotes replication of flaviviruses through modulating cytoskeleton reorganization mediated by NS1. Huang Y, Peng Q, Tian X, Chen C, Zhu X, Huang C, Huo Z, Liu Y, Yang C, Liu C, Zhang P. Nat Commun. 2024 Jan 5;15(1):296. doi: 10.1038/s41467-023-44580-6. PubMed |
| Bivalent activity of super-enhancer RNA LINC02454 controls 3D chromatin structure and regulates glioma sensitivity to temozolomide. Shi T, Guo D, Zheng Y, Wang W, Bi J, He A, Fan S, Su G, Zhao X, Zhao Z, Song Y, Sun S, Li P, Zhao Z, Shi J, Lu W, Zhang L. Cell Death Dis. 2024 Jan 4;15(1):6. doi: 10.1038/s41419-023-06392-w. PubMed |
| Phosphorylation regulates viral biomolecular condensates to promote infectious progeny production. Grams N, Charman M, Halko E, Lauman R, Garcia BA, Weitzman MD. EMBO J. 2024 Jan;43(2):277-303. doi: 10.1038/s44318-023-00021-0. Epub 2024 Jan 2. PubMed |
| Shaping immune landscape of colorectal cancer by cholesterol metabolites. Bai Y, Li T, Wang Q, You W, Yang H, Xu X, Li Z, Zhang Y, Yan C, Yang L, Qiu J, Liu Y, Chen S, Wang D, Huang B, Liu K, Song BL, Wang Z, Li K, Liu X, Wang G, Yang W, Chen J, Hao P, Zhang Z, Wang Z, Zhu ZJ, Xu C. EMBO Mol Med. 2024 Feb;16(2):334-360. doi: 10.1038/s44321-023-00015-9. Epub 2024 Jan 2. PubMed |
| RhoU forms homo-oligomers to regulate cellular responses. Clayton NS, Hodge RG, Infante E, Alibhai D, Zhou F, Ridley AJ. J Cell Sci. 2024 Jan 15;137(2):jcs261645. doi: 10.1242/jcs.261645. Epub 2024 Jan 30. PubMed |
| Intron retention as a productive mechanism in human MAPT: RNA species generated by retention of intron 3. Ruiz-Gabarre D, Valles-Saiz L, Carnero-Espejo A, Ferrer I, Hernandez F, Garcia-Escudero R, Avila J, Garcia-Escudero V. EBioMedicine. 2024 Feb;100:104953. doi: 10.1016/j.ebiom.2023.104953. Epub 2024 Jan 5. PubMed |
| ABCG2 is an itaconate exporter that limits antibacterial innate immunity by alleviating TFEB-dependent lysosomal biogenesis. Chen C, Zhang Z, Liu C, Sun P, Liu P, Li X. Cell Metab. 2024 Mar 5;36(3):498-510.e11. doi: 10.1016/j.cmet.2023.12.015. Epub 2024 Jan 4. PubMed |
| Interferon-stimulated neutrophils as a predictor of immunotherapy response. Benguigui M, Cooper TJ, Kalkar P, Schif-Zuck S, Halaban R, Bacchiocchi A, Kamer I, Deo A, Manobla B, Menachem R, Haj-Shomaly J, Vorontsova A, Raviv Z, Buxbaum C, Christopoulos P, Bar J, Lotem M, Sznol M, Ariel A, Shen-Orr SS, Shaked Y. Cancer Cell. 2024 Feb 12;42(2):253-265.e12. doi: 10.1016/j.ccell.2023.12.005. Epub 2024 Jan 4. PubMed |
| Akt activation ameliorates deficits in hippocampal-dependent memory and activity-dependent synaptic protein synthesis in an Alzheimer's disease mouse model. Kommaddi RP, Gowaikar R, P A H, Diwakar L, Singh K, Mondal A. J Biol Chem. 2024 Feb;300(2):105619. doi: 10.1016/j.jbc.2023.105619. Epub 2024 Jan 3. PubMed |
| Two somatic mutations in the androgen receptor N-terminal domain are oncogenic drivers in hepatocellular carcinoma. Ren QN, Huang DH, Zhang XN, Wang YN, Zhou YF, Zhang MY, Wang SC, Mai SJ, Wu DH, Wang HY. Commun Biol. 2024 Jan 5;7(1):22. doi: 10.1038/s42003-023-05704-2. PubMed |
| R-spondin-1 induces Axin degradation via the LRP6-CK1epsilon axis. Tan L, Yan M, Su Z, Wang H, Li H, Zhao X, Liu S, Zhang L, Sun Q, Lu D. Cell Commun Signal. 2024 Jan 5;22(1):14. doi: 10.1186/s12964-023-01456-y. PubMed |
| Fatty acid amide hydrolase drives adult mammary gland development by promoting luminal cell differentiation. Tundidor I, Seijo-Vila M, Blasco-Benito S, Rubert-Hernandez M, Moreno-Bueno G, Bindila L, de la Rosa RF, Guzman M, Sanchez C, Perez-Gomez E. Cell Death Discov. 2024 Jan 6;10(1):12. doi: 10.1038/s41420-023-01788-1. PubMed |
| High-dimensional phenotyping to define the genetic basis of cellular morphology. Tegtmeyer M, Arora J, Asgari S, Cimini BA, Nadig A, Peirent E, Liyanage D, Way GP, Weisbart E, Nathan A, Amariuta T, Eggan K, Haghighi M, McCarroll SA, O'Connor L, Carpenter AE, Singh S, Nehme R, Raychaudhuri S. Nat Commun. 2024 Jan 6;15(1):347. doi: 10.1038/s41467-023-44045-w. PubMed |
| TDP-43 chronic deficiency leads to dysregulation of transposable elements and gene expression by affecting R-loop and 5hmC crosstalk. Hou Y, Li Y, Xiang JF, Tilahun K, Jiang J, Corces VG, Yao B. Cell Rep. 2024 Jan 23;43(1):113662. doi: 10.1016/j.celrep.2023.113662. Epub 2024 Jan 6. PubMed |
| ATP7A-dependent copper sequestration contributes to termination of beta-CATENIN signaling during early adipogenesis. Yang H, Kabin E, Dong Y, Zhang X, Ralle M, Lutsenko S. Mol Metab. 2024 Feb;80:101872. doi: 10.1016/j.molmet.2024.101872. Epub 2024 Jan 6. PubMed |
| Prickle1-driven basement membrane deposition of the iPSC-derived embryoid bodies is separable from the establishment of apicobasal polarity. Guo D, Liu S, Zhang J, Gu X, Shi L, Su Y, Xu S, Ju R, Wei Y, Liu C. Cell Prolif. 2024 Jun;57(6):e13595. doi: 10.1111/cpr.13595. Epub 2024 Jan 7. PubMed |
| Trans-synaptic molecular context of NMDA receptor nanodomains. Anderson MC, Levy AD, Dharmasri PA, Metzbower SR, Blanpied TA. bioRxiv [Preprint]. 2023 Dec 23:2023.12.22.573055. doi: 10.1101/2023.12.22.573055. PubMed |
| The role of satellite cell-derived TRIM28 in mechanical load- and injury-induced myogenesis. Lin KH, Hibbert JE, Lemens JL, Torbey MM, Steinert ND, Flejsierowicz PM, Melka KM, Lares M, Setaluri V, Hornberger TA. bioRxiv [Preprint]. 2023 Dec 29:2023.12.20.572566. doi: 10.1101/2023.12.20.572566. PubMed |
| Duchenne muscular dystrophy treatment with lentiviral vector containing mini-dystrophin gene in vivo. Wang X, Zhu Y, Liu T, Zhou L, Fu Y, Zhao J, Li Y, Zheng Y, Yang X, Di X, Yang Y, He Z. MedComm (2020). 2024 Jan 6;5(1):e423. doi: 10.1002/mco2.423. eCollection 2024 Jan. PubMed |
| Modulations in the host cell proteome by the hantavirus nucleocapsid protein. Royster A, Ren S, Ali S, Mir S, Mir M. PLoS Pathog. 2024 Jan 8;20(1):e1011925. doi: 10.1371/journal.ppat.1011925. eCollection 2024 Jan. PubMed |
| Mutations accumulated in the Spike of SARS-CoV-2 Omicron allow for more efficient counteraction of the restriction factor BST2/Tetherin. Shi Y, Simpson S, Chen Y, Aull H, Benjamin J, Serra-Moreno R. PLoS Pathog. 2024 Jan 8;20(1):e1011912. doi: 10.1371/journal.ppat.1011912. eCollection 2024 Jan. PubMed |
| Safety and feasibility of anti-CD19 CAR T cells expressing inducible IL-7 and CCL19 in patients with relapsed or refractory large B-cell lymphoma. Lei W, Zhao A, Liu H, Yang C, Wei C, Guo S, Chen Z, Guo Q, Li L, Zhao M, Wu G, Ouyang G, Liu M, Zhang J, Gao J, Qian W. Cell Discov. 2024 Jan 9;10(1):5. doi: 10.1038/s41421-023-00625-0. PubMed |
| Selective gene expression maintains human tRNA anticodon pools during differentiation. Gao L, Behrens A, Rodschinka G, Forcelloni S, Wani S, Strasser K, Nedialkova DD. Nat Cell Biol. 2024 Jan;26(1):100-112. doi: 10.1038/s41556-023-01317-3. Epub 2024 Jan 8. PubMed |
| Chemoproteomic development of SLC15A4 inhibitors with anti-inflammatory activity. Chiu TY, Lazar DC, Wang WW, Wozniak JM, Jadhav AM, Li W, Gazaniga N, Theofilopoulos AN, Teijaro JR, Parker CG. Nat Chem Biol. 2024 Aug;20(8):1000-1011. doi: 10.1038/s41589-023-01527-8. Epub 2024 Jan 8. PubMed |
| Targeted Protein Degradation through Recruitment of the CUL4 Complex Adaptor Protein DDB1. Meyers M, Cismoski S, Panidapu A, Chie-Leon B, Nomura DK. ACS Chem Biol. 2024 Jan 19;19(1):58-68. doi: 10.1021/acschembio.3c00487. Epub 2024 Jan 8. PubMed |
| Suppression of NBS1 Upregulates CyclinB to Induce Olaparib Sensitivity in Ovarian Cancer. Zhong A, Cheng CS, Lu RQ, Guo L. Technol Cancer Res Treat. 2024 Jan-Dec;23:15330338231212085. doi: 10.1177/15330338231212085. PubMed |
| Distinct spatiotemporal dynamics of CD8(+) T cell-derived cytokines in the tumor microenvironment. Hoekstra ME, Slagter M, Urbanus J, Toebes M, Slingerland N, de Rink I, Kluin RJC, Nieuwland M, Kerkhoven R, Wessels LFA, Schumacher TN. Cancer Cell. 2024 Jan 8;42(1):157-167.e9. doi: 10.1016/j.ccell.2023.12.010. PubMed |
| Computational prediction and experimental validation identify functionally conserved lncRNAs from zebrafish to human. Huang W, Xiong T, Zhao Y, Heng J, Han G, Wang P, Zhao Z, Shi M, Li J, Wang J, Wu Y, Liu F, Xi JJ, Wang Y, Zhang QC. Nat Genet. 2024 Jan;56(1):124-135. doi: 10.1038/s41588-023-01620-7. Epub 2024 Jan 9. PubMed |
| Passenger Gene Coamplifications Create Collateral Therapeutic Vulnerabilities in Cancer. Bei Y, Brame L, Kirchner M, Fritsche-Guenther R, Kunz S, Bhattacharya A, Rusu MC, Gurgen D, Dubios FPB, Koppke JKC, Proba J, Wittstruck N, Sidorova OA, Chamorro Gonzalez R, Dorado Garcia H, Bruckner L, Xu R, Giurgiu M, Rodriguez-Fos E, Yu Q, Spanjaard B, Koche RP, Schmitt CA, Schulte JH, Eggert A, Haase K, Kirwan J, Hagemann AIH, Mertins P, Dorr JR, Henssen AG. Cancer Discov. 2024 Mar 1;14(3):492-507. doi: 10.1158/2159-8290.CD-23-1189. PubMed |
METTL17 is an Fe-S cluster checkpoint for mitochondrial translation.
Ast T, Itoh Y, Sadre S, McCoy JG, Namkoong G, Wengrod JC, Chicherin I, Joshi PR, Kamenski P, Suess DLM, Amunts A, Mootha VK.
Mol Cell. 2024 Jan 18;84(2):359-374.e8. doi: 10.1016/j.molcel.2023.12.016. Epub 2024 Jan 9.
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| LATS2 condensates organize signalosomes for Hippo pathway signal transduction. Qin M, Geng E, Wang J, Yu M, Dong T, Li S, Zhang X, Lin J, Shi M, Li J, Zhang H, Chen L, Cao X, Huang L, Wang M, Li Y, Yang XP, Zhao B, Sun S. Nat Chem Biol. 2024 Jan 10. doi: 10.1038/s41589-023-01516-x. PubMed |
MRE11 liberates cGAS from nucleosome sequestration during tumorigenesis.
Cho MG, Kumar RJ, Lin CC, Boyer JA, Shahir JA, Fagan-Solis K, Simpson DA, Fan C, Foster CE, Goddard AM, Lerner LM, Ellington SW, Wang Q, Wang Y, Ho AY, Liu P, Perou CM, Zhang Q, McGinty RK, Purvis JE, Gupta GP.
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| Targeting the SphK1/S1P/PFKFB3 axis suppresses hepatocellular carcinoma progression by disrupting glycolytic energy supply that drives tumor angiogenesis. Liu XT, Huang Y, Liu D, Jiang YC, Zhao M, Chung LH, Han XD, Zhao Y, Chen J, Coleman P, Ting KK, Tran C, Su Y, Dennis CV, Bhatnagar A, Liu K, Don AS, Vadas MA, Gorrell MD, Zhang S, Murray M, Kavurma MM, McCaughan GW, Gamble JR, Qi Y. J Transl Med. 2024 Jan 10;22(1):43. doi: 10.1186/s12967-023-04830-z. PubMed |
| A Functional Single-Nucleotide Polymorphism Upstream of the Collagen Type III Gene Is Associated with Catastrophic Fracture Risk in Thoroughbred Horses. Palomino Lago E, Baird A, Blott SC, McPhail RE, Ross AC, Durward-Akhurst SA, Guest DJ. Animals (Basel). 2023 Dec 28;14(1):116. doi: 10.3390/ani14010116. PubMed |
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| Activation of Young LINE-1 Elements by CRISPRa. Tong B, Sun Y. Int J Mol Sci. 2023 Dec 28;25(1):424. doi: 10.3390/ijms25010424. PubMed |
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| TALK-1-mediated alterations of beta-cell mitochondrial function and insulin secretion impair glucose homeostasis on a diabetogenic diet. Graff SM, Nakhe AY, Dadi PK, Dickerson MT, Dobson JR, Zaborska KE, Ibsen CE, Butterworth RB, Vierra NC, Jacobson DA. Cell Rep. 2024 Jan 23;43(1):113673. doi: 10.1016/j.celrep.2024.113673. Epub 2024 Jan 10. PubMed |
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Pioneer and PRDM transcription factors coordinate bivalent epigenetic states to safeguard cell fate.
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Mol Cell. 2024 Jan 4:S1097-2765(23)01026-2. doi: 10.1016/j.molcel.2023.12.007.
PubMed
Associated Plasmids |
Long-term labeling and imaging of synaptically connected neuronal networks in vivo using double-deletion-mutant rabies viruses.
Jin L, Sullivan HA, Zhu M, Lavin TK, Matsuyama M, Fu X, Lea NE, Xu R, Hou Y, Rutigliani L, Pruner M, Babcock KR, Ip JPK, Hu M, Daigle TL, Zeng H, Sur M, Feng G, Wickersham IR.
Nat Neurosci. 2024 Jan 11. doi: 10.1038/s41593-023-01545-8.
PubMed
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| Disordered-to-ordered transitions in assembly factors allow the complex II catalytic subunit to switch binding partners. Sharma P, Maklashina E, Voehler M, Balintova S, Dvorakova S, Kraus M, Vanova KH, Nahacka Z, Zobalova R, Boukalova S, Cunatova K, Mracek T, Ghayee HK, Pacak K, Rohlena J, Neuzil J, Cecchini G, Iverson TM. Nat Commun. 2024 Jan 11;15(1):473. doi: 10.1038/s41467-023-44563-7. PubMed |
| Functional interactions between neurofibromatosis tumor suppressors underlie Schwann cell tumor de-differentiation and treatment resistance. Vasudevan HN, Payne E, Delley CL, John Liu S, Mirchia K, Sale MJ, Lastella S, Nunez MS, Lucas CG, Eaton CD, Casey-Clyde T, Magill ST, Chen WC, Braunstein SE, Perry A, Jacques L, Reddy AT, Pekmezci M, Abate AR, McCormick F, Raleigh DR. Nat Commun. 2024 Jan 12;15(1):477. doi: 10.1038/s41467-024-44755-9. PubMed |
| TKT-PARP1 axis induces radioresistance by promoting DNA double-strand break repair in hepatocellular carcinoma. Geng L, Zhu M, Luo D, Chen H, Li B, Lao Y, An H, Wu Y, Li Y, Xia A, Shi Y, Tong Z, Lu S, Xu D, Wang X, Zhang W, Sun B, Xu Z. Oncogene. 2024 Feb;43(9):682-692. doi: 10.1038/s41388-023-02935-9. Epub 2024 Jan 12. PubMed |
| dCas9/CRISPR-based methylation of O-6-methylguanine-DNA methyltransferase enhances chemosensitivity to temozolomide in malignant glioma. Zapanta Rinonos S, Li T, Pianka ST, Prins TJ, Eldred BSC, Kevan BM, Liau LM, Nghiemphu PL, Cloughesy TF, Lai A. J Neurooncol. 2024 Jan;166(1):129-142. doi: 10.1007/s11060-023-04531-z. Epub 2024 Jan 15. PubMed |
| Generation and optimization of off-the-shelf immunotherapeutics targeting TCR-Vbeta2+ T cell malignancy. Ren J, Liao X, Lewis JM, Chang J, Qu R, Carlson KR, Foss F, Girardi M. Nat Commun. 2024 Jan 15;15(1):519. doi: 10.1038/s41467-024-44786-2. PubMed |
| Ribogenesis boosts controlled by HEATR1-MYC interplay promote transition into brain tumour growth. Diaz LR, Gil-Ranedo J, Jaworek KJ, Nsek N, Marques JP, Costa E, Hilton DA, Bieluczyk H, Warrington O, Hanemann CO, Futschik ME, Bossing T, Barros CS. EMBO Rep. 2024 Jan;25(1):168-197. doi: 10.1038/s44319-023-00017-1. Epub 2024 Jan 15. PubMed |
| Production of infectious reporter murine norovirus by VP2 trans-complementation. Ishiyama R, Yoshida K, Oikawa K, Takai-Todaka R, Kato A, Kanamori K, Nakanishi A, Haga K, Katayama K. J Virol. 2024 Feb 20;98(2):e0126123. doi: 10.1128/jvi.01261-23. Epub 2024 Jan 16. PubMed |
| Intrahepatic homeobox protein MSX-1 is a novel host restriction factor of hepatitis B virus. Shen Z, Zhang S, Gao Z, Yu X, Wang J, Pan S, Kang N, Liu N, Xu H, Liu M, Yang Y, Deng Q, Liu J, Xie Y, Zhang J. J Virol. 2024 Feb 20;98(2):e0134523. doi: 10.1128/jvi.01345-23. Epub 2024 Jan 16. PubMed |
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| Nucleolar protein TAAP1/C22orf46 confers pro-survival signaling in non-small cell lung cancer. Doring M, Brux M, Paszkowski-Rogacz M, Guillem-Gloria PM, Buchholz F, Pisabarro MT, Theis M. Life Sci Alliance. 2024 Jan 16;7(4):e202302257. doi: 10.26508/lsa.202302257. Print 2024 Apr. PubMed |
| BMP-ACVR1 Axis is Critical for Efficacy of PRC2 Inhibitors in B-Cell Lymphoma. Liu D, Li Z, Tan D, An Y, Chu L, Chen T, Li W, Zhou A, Xiang R, Zhang L, Qu Y, Qi W. Adv Sci (Weinh). 2024 Mar;11(12):e2306499. doi: 10.1002/advs.202306499. Epub 2024 Jan 16. PubMed |
| Neuronal MAPT expression is mediated by long-range interactions with cis-regulatory elements. Rogers BB, Anderson AG, Lauzon SN, Davis MN, Hauser RM, Roberts SC, Rodriguez-Nunez I, Trausch-Lowther K, Barinaga EA, Hall PI, Knuesel MT, Taylor JW, Mackiewicz M, Roberts BS, Cooper SJ, Rizzardi LF, Myers RM, Cochran JN. Am J Hum Genet. 2024 Feb 1;111(2):259-279. doi: 10.1016/j.ajhg.2023.12.015. Epub 2024 Jan 16. PubMed |
| c-Fos regulated by TMPO/ERK axis promotes 5-FU resistance via inducing NANOG transcription in colon cancer. Gui Y, Qian X, Ding Y, Chen Q, Fangyu Ye, Ye Y, Hou Y, Yu J, Zhao L. Cell Death Dis. 2024 Jan 17;15(1):61. doi: 10.1038/s41419-024-06451-w. PubMed |
| Alternative splicing of latrophilin-3 controls synapse formation. Wang S, DeLeon C, Sun W, Quake SR, Roth BL, Sudhof TC. Nature. 2024 Feb;626(7997):128-135. doi: 10.1038/s41586-023-06913-9. Epub 2024 Jan 17. PubMed |
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| SUMOylation of the m6A reader YTHDF2 by PIAS1 promotes viral RNA decay to restrict EBV replication. Sugiokto FG, Saiada F, Zhang K, Li R. mBio. 2024 Feb 14;15(2):e0316823. doi: 10.1128/mbio.03168-23. Epub 2024 Jan 18. PubMed |
| Recruitment of BAG2 to DNAJ-PKAc scaffolds promotes cell survival and resistance to drug-induced apoptosis in fibrolamellar carcinoma. Lauer SM, Omar MH, Golkowski MG, Kenerson HL, Lee KS, Pascual BC, Lim HC, Forbush K, Smith FD, Gordan JD, Ong SE, Yeung RS, Scott JD. Cell Rep. 2024 Feb 27;43(2):113678. doi: 10.1016/j.celrep.2024.113678. Epub 2024 Jan 17. PubMed |
| USP22 overexpression fails to augment tumor formation in MMTV-ERBB2 mice but loss of function impacts MMTV promoter activity. Kuang X, Salinger A, Benavides F, Muller WJ, Dent SYR, Koutelou E. PLoS One. 2024 Jan 18;19(1):e0290837. doi: 10.1371/journal.pone.0290837. eCollection 2024. PubMed |
| A synthetic agent ameliorates polycystic kidney disease by promoting apoptosis of cystic cells through increased oxidative stress. Fedeles BI, Bhardwaj R, Ishikawa Y, Khumsubdee S, Krappitz M, Gubina N, Volpe I, Andrade DC, Westergerling P, Staudner T, Campolo J, Liu SS, Dong K, Cai Y, Rehman M, Gallagher AR, Ruchirawat S, Croy RG, Essigmann JM, Fedeles SV, Somlo S. Proc Natl Acad Sci U S A. 2024 Jan 23;121(4):e2317344121. doi: 10.1073/pnas.2317344121. Epub 2024 Jan 19. PubMed |
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| The CUL5 E3 ligase complex negatively regulates central signaling pathways in CD8(+) T cells. Liao X, Li W, Zhou H, Rajendran BK, Li A, Ren J, Luan Y, Calderwood DA, Turk B, Tang W, Liu Y, Wu D. Nat Commun. 2024 Jan 19;15(1):603. doi: 10.1038/s41467-024-44885-0. PubMed |
| CircNUP50 is a novel therapeutic target that promotes cisplatin resistance in ovarian cancer by modulating p53 ubiquitination. Zhu Y, Liang L, Zhao Y, Li J, Zeng J, Yuan Y, Li N, Wu L. J Nanobiotechnology. 2024 Jan 19;22(1):35. doi: 10.1186/s12951-024-02295-w. PubMed |
| LDLR is used as a cell entry receptor by multiple alphaviruses. Zhai X, Li X, Veit M, Wang N, Wang Y, Merits A, Jiang Z, Qin Y, Zhang X, Qi K, Jiao H, He WT, Chen Y, Mao Y, Su S. Nat Commun. 2024 Jan 20;15(1):622. doi: 10.1038/s41467-024-44872-5. PubMed |
| LUBAC-mediated M1 Ub regulates necroptosis by segregating the cellular distribution of active MLKL. Weinelt N, Wachtershauser KN, Celik G, Jeiler B, Gollin I, Zein L, Smith S, Andrieux G, Das T, Roedig J, Feist L, Rotter B, Boerries M, Pampaloni F, van Wijk SJL. Cell Death Dis. 2024 Jan 20;15(1):77. doi: 10.1038/s41419-024-06447-6. PubMed |
| A Novel Anti-CD47 Nanobody Tetramer for Cancer Therapy. Ratnikova NM, Kravchenko Y, Ivanova A, Zhuchkov V, Frolova E, Chumakov S. Antibodies (Basel). 2024 Jan 2;13(1):2. doi: 10.3390/antib13010002. PubMed |
| Isolation and Characterization of Neutralizing Monoclonal Antibodies from a Large Panel of Murine Antibodies against RBD of the SARS-CoV-2 Spike Protein. D'Acunto E, Muzi A, Marchese S, Donnici L, Chiarini V, Bucci F, Pavoni E, Ferrara FF, Cappelletti M, Arriga R, Serrao SM, Peluzzi V, Principato E, Compagnone M, Pinto E, Luberto L, Stoppoloni D, Lahm A, Gross R, Seidel A, Wettstein L, Munch J, Goodhead A, Parisot J, De Francesco R, Ciliberto G, Marra E, Aurisicchio L, Roscilli G. Antibodies (Basel). 2024 Jan 5;13(1):5. doi: 10.3390/antib13010005. PubMed |
| TGFbeta and Hippo Signaling Pathways Coordinate to Promote Acinar to Ductal Metaplasia in Human Pancreas. Nipper M, Xu Y, Liu J, Yin X, Liu Z, Ye Z, Zhang J, Chen Y, Wang P. Cells. 2024 Jan 18;13(2):186. doi: 10.3390/cells13020186. PubMed |
| OPN promotes pro-inflammatory cytokine expression via ERK/JNK pathway and M1 macrophage polarization in Rosacea. Tang S, Hu H, Li M, Zhang K, Wu Q, Liu X, Wu L, Yu B, Chen X. Front Immunol. 2024 Jan 5;14:1285951. doi: 10.3389/fimmu.2023.1285951. eCollection 2023. PubMed |
| Generation of a Porcine Cell Line Stably Expressing Pig TMPRSS2 for Efficient Isolation of Swine Influenza Virus. Tanaka YL, Shofa M, Butlertanaka EP, Niazi AM, Hirai T, Mekata H, Saito A. Pathogens. 2023 Dec 24;13(1):18. doi: 10.3390/pathogens13010018. PubMed |
| KLRG1 Cell Depletion as a Novel Therapeutic Strategy in Patients with Mature T-Cell Lymphoma Subtypes. Assatova B, Willim R, Trevisani C, Haskett G, Kariya KM, Chopra K, Park SR, Tolstorukov MY, McCabe SM, Duffy J, Louissaint A Jr, Huuhtanen J, Bhattacharya D, Mustjoki S, Koh MJ, Powers F, Morgan EA, Yang L, Pinckney B, Cotton MJ, Crabbe A, Ziemba JB, Brain I, Heavican-Foral TB, Iqbal J, Nemec R, Rider AB, Ford JG, Koh MJ, Scanlan N, Feith DJ, Loughran TP Jr, Kim WS, Choi J, Roels J, Boehme L, Putteman T, Taghon T, Barnes JA, Johnson PC, Jacobsen ED, Greenberg SA, Weinstock DM, Jain S. Clin Cancer Res. 2024 Jun 3;30(11):2514-2530. doi: 10.1158/1078-0432.CCR-23-3504. PubMed |
| Multi-Omics Profiling Identifies Microglial Annexin A2 as a Key Mediator of NF-kappaB Pro-inflammatory Signaling in Ischemic Reperfusion Injury. Tian X, Yang W, Jiang W, Zhang Z, Liu J, Tu H. Mol Cell Proteomics. 2024 Feb;23(2):100723. doi: 10.1016/j.mcpro.2024.100723. Epub 2024 Jan 20. PubMed |
| RBL2 represses the transcriptional activity of Multicilin to inhibit multiciliogenesis. Quiroz EJ, Kim S, Gautam LK, Borok Z, Kintner C, Ryan AL. Cell Death Dis. 2024 Jan 22;15(1):81. doi: 10.1038/s41419-024-06440-z. PubMed |
| PICH deficiency limits the progression of MYC-induced B-cell lymphoma. Castejon-Grinan M, Albers E, Simon-Carrasco L, Aguilera P, Sbroggio M, Pladevall-Morera D, Ingham A, Lim E, Guillen-Benitez A, Pietrini E, Lisby M, Hickson ID, Lopez-Contreras AJ. Blood Cancer J. 2024 Jan 23;14(1):16. doi: 10.1038/s41408-024-00979-y. PubMed |
| Functional Analysis of KAP1/TRIM28 Requirements for HIV-1 Transcription Activation. Randolph K, Hyder U, Challa A, Perez E, D'Orso I. Viruses. 2024 Jan 13;16(1):116. doi: 10.3390/v16010116. PubMed |
| Chimeric antigen-receptor (CAR) engineered natural killer cells in a chronic myeloid leukemia (CML) blast crisis model. Imeri J, Marcoux P, Huyghe M, Desterke C, Fantacini DMC, Griscelli F, Covas DT, de Souza LEB, Griscelli AB, Turhan AG. Front Immunol. 2024 Jan 8;14:1309010. doi: 10.3389/fimmu.2023.1309010. eCollection 2023. PubMed |
| Constitutive Endolysosomal Perforation in Neurons allows Induction of alpha-Synuclein Aggregation by Internalized Pre-Formed Fibrils. Sanyal A, Scanavachi G, Somerville E, Saminathan A, Nair A, Oikonomou A, Hatzakis NS, Kirchhausen T. bioRxiv [Preprint]. 2024 Jan 1:2023.12.30.573738. doi: 10.1101/2023.12.30.573738. PubMed |
| Mutations in the non-catalytic polyproline motif destabilize TREX1 and amplify cGAS-STING signaling. Shim A, Luan X, Zhou W, Crow Y, Maciejowski J. bioRxiv [Preprint]. 2024 Jan 4:2024.01.04.574136. doi: 10.1101/2024.01.04.574136. PubMed |
| Direct interrogation of context-dependent GPCR activity with a universal biosensor platform. Janicot R, Maziarz M, Park JC, Luebbers A, Green E, Zhao J, Philibert C, Zhang H, Layne MD, Wu JC, Garcia-Marcos M. bioRxiv [Preprint]. 2024 Jan 2:2024.01.02.573921. doi: 10.1101/2024.01.02.573921. PubMed |
| Cytoplasmic accumulation and plasma membrane association of anillin and Ect2 promote confined migration and invasion. Tran AT, Wisniewski EO, Mistriotis P, Stoletov K, Parlani M, Amitrano A, Ifemembi B, Lee SJ, Bera K, Zhang Y, Tuntithavornwat S, Afthinos A, Kiepas A, Jamieson JJ, Zuo Y, Habib D, Wu PH, Martin SS, Gerecht S, Gu L, Lewis JD, Kalab P, Friedl P, Konstantopoulos K. Res Sq [Preprint]. 2024 Jan 10:rs.3.rs-3640969. doi: 10.21203/rs.3.rs-3640969/v1. PubMed |
| RhoA activation promotes glucose uptake to elevate proliferation in MAPK inhibitor resistant melanoma cells. Murali VS, Rajendran D, Isogai T, DeBerardinis RJ, Danuser G. bioRxiv [Preprint]. 2024 Jan 11:2024.01.09.574940. doi: 10.1101/2024.01.09.574940. PubMed |
| A basally active cGAS-STING pathway limits SARS-CoV-2 replication in a subset of ACE2 positive airway cell models. Puray-Chavez M, LaPak KM, Jasuja R, Pan J, Xu J, Eschbach JE, Mohammed S, Lawson DQ, Wang Q, Brody SL, Major MB, Goldfarb D, Kutluay SB. bioRxiv [Preprint]. 2024 Jan 8:2024.01.07.574522. doi: 10.1101/2024.01.07.574522. PubMed |
| Systematic analysis of nonsense variants uncovers peptide release rate as a novel modifier of nonsense-mediated mRNA decay efficiency. Kolakada D, Fu R, Biziaev N, Shuvalov A, Lore M, Campbell AE, Cortazar MA, Sajek MP, Hesselberth JR, Mukherjee N, Alkalaeva E, Jagannathan S. bioRxiv [Preprint]. 2024 Apr 23:2024.01.10.575080. doi: 10.1101/2024.01.10.575080. PubMed |
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| Engineering an Autonucleolytic Mammalian Suspension Host Cell Line to Reduce DNA Impurity Levels in Serum-Free Lentiviral Process Streams. Howe G, Wasmuth M, Emanuelle P, Massaro G, Rahim AA, Ali S, Rivera M, Ward J, Keshavarz-Moore E, Mason C, Nesbeth DN. ACS Synth Biol. 2024 Feb 16;13(2):466-473. doi: 10.1021/acssynbio.3c00682. Epub 2024 Jan 24. PubMed |
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| Epigenetic priming targets tumor heterogeneity to shift transcriptomic phenotype of pancreatic ductal adenocarcinoma towards a Vitamin D susceptible state. He B, Stoffel L, He CJ, Cho K, Li AM, Jiang H, Flowers BM, Nguyen KT, Wang KW, Zhao AY, Zhou MN, Ferreira S, Attardi LD, Ye J. Cell Death Dis. 2024 Jan 26;15(1):89. doi: 10.1038/s41419-024-06460-9. PubMed |
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| Loss of filamentous actin, tight junction protein expression, and paracellular barrier integrity in frataxin-deficient human brain microvascular endothelial cells-implications for blood-brain barrier physiology in Friedreich's ataxia. Smith FM, Kosman DJ. Front Mol Biosci. 2024 Jan 11;10:1299201. doi: 10.3389/fmolb.2023.1299201. eCollection 2023. PubMed |
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| UBR5 promotes antiviral immunity by disengaging the transcriptional brake on RIG-I like receptors. Yang D, Geng T, Harrison AG, Cahoon JG, Xing J, Jiao B, Wang M, Cheng C, Hill RE, Wang H, Vella AT, Cheng G, Wang Y, Wang P. Nat Commun. 2024 Jan 26;15(1):780. doi: 10.1038/s41467-024-45141-1. PubMed |
| Vascular injury activates the ELK1/SND1/SRF pathway to promote vascular smooth muscle cell proliferative phenotype and neointimal hyperplasia. Su C, Liu M, Yao X, Hao W, Ma J, Ren Y, Gao X, Xin L, Ge L, Yu Y, Wei M, Yang J. Cell Mol Life Sci. 2024 Jan 27;81(1):59. doi: 10.1007/s00018-023-05095-x. PubMed |
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| Immortalization of American miniature horse-derived fibroblast by cell cycle regulator with normal karyotype. Tani T. PeerJ. 2024 Jan 26;12:e16832. doi: 10.7717/peerj.16832. eCollection 2024. PubMed |
| NPAS2 dampens chemo-sensitivity of lung adenocarcinoma cells by enhancing DNA damage repair. Zhang Y, Chen Y, Huang W, Zhou Y, Wang Y, Fu K, Zhuang W. Cell Death Dis. 2024 Jan 30;15(1):101. doi: 10.1038/s41419-023-06256-3. PubMed |
| Genome scale CRISPR screens identify actin capping proteins as key modulators of therapeutic responses to radiation and immunotherapy. Verma N, Renauer PA, Dong C, Xin S, Lin Q, Zhang F, Glazer PM, Chen S. bioRxiv [Preprint]. 2024 Jan 15:2024.01.14.575614. doi: 10.1101/2024.01.14.575614. PubMed |
| NRAS Mutant Dictates AHCYL1-Governed ER Calcium Homeostasis for Melanoma Tumor Growth. Cai C, Tu J, Najarro J, Zhang R, Fan H, Zhang FQ, Li J, Xie Z, Su R, Dong L, Arellano N, Ciboddo M, Elf SE, Gao X, Chen J, Wu R. Mol Cancer Res. 2024 Apr 2;22(4):386-401. doi: 10.1158/1541-7786.MCR-23-0445. PubMed |
| Dimethyl alpha-Ketoglutarate Promotes the Synthesis of Collagen and Inhibits Metalloproteinases in HaCaT Cells. Yu BY, Eom DH, Kim HW, Jeong YJ, Keum YS. Biomol Ther (Seoul). 2024 Mar 1;32(2):240-248. doi: 10.4062/biomolther.2023.131. Epub 2024 Feb 1. PubMed |
| HBV promotes its replication by up-regulating RAD51C gene expression. Peng TW, Ma QF, Li J, Wang X, Zhang CH, Ma J, Li JY, Wang W, Zhu CL, Liu XH. Sci Rep. 2024 Jan 31;14(1):2607. doi: 10.1038/s41598-024-53047-7. PubMed |
| An epigenetic barrier sets the timing of human neuronal maturation. Ciceri G, Baggiolini A, Cho HS, Kshirsagar M, Benito-Kwiecinski S, Walsh RM, Aromolaran KA, Gonzalez-Hernandez AJ, Munguba H, Koo SY, Xu N, Sevilla KJ, Goldstein PA, Levitz J, Leslie CS, Koche RP, Studer L. Nature. 2024 Feb;626(8000):881-890. doi: 10.1038/s41586-023-06984-8. Epub 2024 Jan 31. PubMed |
| Liver regulatory mechanisms of noncoding variants at lipid and metabolic trait loci. Pandey GK, Vadlamudi S, Currin KW, Moxley AH, Nicholas JC, McAfee JC, Broadaway KA, Mohlke KL. HGG Adv. 2024 Apr 11;5(2):100275. doi: 10.1016/j.xhgg.2024.100275. Epub 2024 Jan 30. PubMed |
| The Parkinson's disease related mutant VPS35 (D620N) amplifies the LRRK2 response to endolysosomal stress. McCarron KR, Elcocks H, Mortiboys H, Urbe S, Clague MJ. Biochem J. 2024 Feb 21;481(4):265-278. doi: 10.1042/BCJ20230492. PubMed |
| The chromatin-associated lncREST ensures effective replication stress response by promoting the assembly of fork signaling factors. Statello L, Fernandez-Justel JM, Gonzalez J, Montes M, Ranieri A, Goni E, Mas AM, Huarte M. Nat Commun. 2024 Feb 1;15(1):978. doi: 10.1038/s41467-024-45183-5. PubMed |
| Nuclear to cytoplasmic transport is a druggable dependency in MYC-driven hepatocellular carcinoma. Deutzmann A, Sullivan DK, Dhanasekaran R, Li W, Chen X, Tong L, Mahauad-Fernandez WD, Bell J, Mosley A, Koehler AN, Li Y, Felsher DW. Nat Commun. 2024 Feb 1;15(1):963. doi: 10.1038/s41467-024-45128-y. PubMed |
| METTL16 promotes liver cancer stem cell self-renewal via controlling ribosome biogenesis and mRNA translation. Xue M, Dong L, Zhang H, Li Y, Qiu K, Zhao Z, Gao M, Han L, Chan AKN, Li W, Leung K, Wang K, Pokharel SP, Qing Y, Liu W, Wang X, Ren L, Bi H, Yang L, Shen C, Chen Z, Melstrom L, Li H, Timchenko N, Deng X, Huang W, Rosen ST, Tian J, Xu L, Diao J, Chen CW, Chen J, Shen B, Chen H, Su R. J Hematol Oncol. 2024 Feb 1;17(1):7. doi: 10.1186/s13045-024-01526-9. PubMed |
| Inhibition of anti-tumor immunity by melanoma cell-derived Activin-A depends on STING. Pinjusic K, Ambrosini G, Lourenco J, Fournier N, Iseli C, Guex N, Egorova O, Nassiri S, Constam DB. Front Immunol. 2024 Jan 18;14:1335207. doi: 10.3389/fimmu.2023.1335207. eCollection 2023. PubMed |
Notch3 directs differentiation of brain mural cells from human pluripotent stem cell-derived neural crest.
Gastfriend BD, Snyder ME, Holt HE, Daneman R, Palecek SP, Shusta EV.
Sci Adv. 2024 Feb 2;10(5):eadi1737. doi: 10.1126/sciadv.adi1737. Epub 2024 Feb 2.
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| Discoveries of GPR39 as an evolutionarily conserved receptor for bile acids and of its involvement in biliary acute pancreatitis. Zi Z, Rao Y. Sci Adv. 2024 Feb 2;10(5):eadj0146. doi: 10.1126/sciadv.adj0146. Epub 2024 Feb 2. PubMed |
| 3D bioprinting of human neural tissues with functional connectivity. Yan Y, Li X, Gao Y, Mathivanan S, Kong L, Tao Y, Dong Y, Li X, Bhattacharyya A, Zhao X, Zhang SC. Cell Stem Cell. 2024 Feb 1;31(2):260-274.e7. doi: 10.1016/j.stem.2023.12.009. PubMed |
| IkappaBzeta is a dual-use coactivator of NF-kappaB and POU transcription factors. Alpsoy A, Wu XS, Pal S, Klingbeil O, Kumar P, El Demerdash O, Nalbant B, Vakoc CR. Mol Cell. 2024 Mar 21;84(6):1149-1157.e7. doi: 10.1016/j.molcel.2024.01.007. Epub 2024 Feb 2. PubMed |
| Alternative polyadenylation determines the functional landscape of inverted Alu repeats. Ku J, Lee K, Ku D, Kim S, Lee J, Bang H, Kim N, Do H, Lee H, Lim C, Han J, Lee YS, Kim Y. Mol Cell. 2024 Mar 21;84(6):1062-1077.e9. doi: 10.1016/j.molcel.2024.01.008. Epub 2024 Feb 2. PubMed |
| Engineering lentivirus envelope VSV-G for liver targeted delivery of IDOL-shRNA to ameliorate hypercholesterolemia and atherosclerosis. Wang W, Chen X, Chen J, Xu M, Liu Y, Yang S, Zhao W, Tan S. Mol Ther Nucleic Acids. 2024 Jan 11;35(1):102115. doi: 10.1016/j.omtn.2024.102115. eCollection 2024 Mar 12. PubMed |
CRISPR screen for protein inclusion formation uncovers a role for SRRD in the regulation of intermediate filament dynamics and aggresome assembly.
Sweeney KM, Chantarawong S, Barbieri EM, Cajka G, Liu M, Spruce L, Fazelinia H, Portz B, Copley K, Lapidot T, Duhamel L, Greenwald P, Saida N, Shalgi R, Shorter J, Shalem O.
PLoS Genet. 2024 Feb 5;20(2):e1011138. doi: 10.1371/journal.pgen.1011138. eCollection 2024 Feb.
PubMed
Associated Plasmids |
| The host RNA polymerase II C-terminal domain is the anchor for replication of the influenza virus genome. Krischuns T, Arragain B, Isel C, Paisant S, Budt M, Wolff T, Cusack S, Naffakh N. Nat Commun. 2024 Feb 5;15(1):1064. doi: 10.1038/s41467-024-45205-2. PubMed |
| A novel class of inhibitors that disrupts the stability of integrin heterodimers identified by CRISPR-tiling-instructed genetic screens. Mattson NM, Chan AKN, Miyashita K, Mukhaleva E, Chang WH, Yang L, Ma N, Wang Y, Pokharel SP, Li M, Liu Q, Xu X, Chen R, Singh P, Zhang L, Elsayed Z, Chen B, Keen D, Pirrotte P, Rosen ST, Chen J, LaBarge MA, Shively JE, Vaidehi N, Rockne RC, Feng M, Chen CW. Nat Struct Mol Biol. 2024 Mar;31(3):465-475. doi: 10.1038/s41594-024-01211-y. Epub 2024 Feb 5. PubMed |
| Sterile inflammation via TRPM8 RNA-dependent TLR3-NF-kB/IRF3 activation promotes antitumor immunity in prostate cancer. Alaimo A, Genovesi S, Annesi N, De Felice D, Subedi S, Macchia A, La Manna F, Ciani Y, Vannuccini F, Mugoni V, Notarangelo M, Libergoli M, Broso F, Taulli R, Ala U, Savino A, Cortese M, Mirzaaghaei S, Poli V, Bonapace IM, Papotti MG, Molinaro L, Doglioni C, Caffo O, Anesi A, Nagler M, Bertalot G, Carbone FG, Barbareschi M, Basso U, Dassi E, Pizzato M, Romanel A, Demichelis F, Kruithof-de Julio M, Lunardi A. EMBO J. 2024 Mar;43(5):780-805. doi: 10.1038/s44318-024-00040-5. Epub 2024 Feb 5. PubMed |
| Genome-wide quantification of copy-number aberration impact on gene expression in ovarian high-grade serous carcinoma. Jamalzadeh S, Dai J, Lavikka K, Li Y, Jiang J, Huhtinen K, Virtanen A, Oikkonen J, Hietanen S, Hynninen J, Vaharautio A, Hakkinen A, Hautaniemi S. BMC Cancer. 2024 Feb 5;24(1):173. doi: 10.1186/s12885-024-11895-6. PubMed |
| SETDB1 promotes progression through upregulation of SF3B4 expression and regulates the immunity in ovarian cancer. Yang H, Sui L, Cai C, Chu H, Diao Y. J Ovarian Res. 2024 Feb 5;17(1):34. doi: 10.1186/s13048-024-01358-8. PubMed |
| Differential histone acetylation and super-enhancer regulation underlie melanoma cell dedifferentiation. Mendelson K, Martin TC, Nguyen CB, Hsu M, Xu J, Lang C, Dummer R, Saenger Y, Messina JL, Sondak VK, Desman G, Hasson D, Bernstein E, Parsons RE, Celebi JT. JCI Insight. 2024 Feb 6;9(6):e166611. doi: 10.1172/jci.insight.166611. PubMed |
| The cyclimids: Degron-inspired cereblon binders for targeted protein degradation. Ichikawa S, Payne NC, Xu W, Chang CF, Vallavoju N, Frome S, Flaxman HA, Mazitschek R, Woo CM. Cell Chem Biol. 2024 Jun 20;31(6):1162-1175.e10. doi: 10.1016/j.chembiol.2024.01.003. Epub 2024 Feb 5. PubMed |
| Integrating leiomyoma genetics, epigenomics, and single-cell transcriptomics reveals causal genetic variants, genes, and cell types. Buyukcelebi K, Duval AJ, Abdula F, Elkafas H, Seker-Polat F, Adli M. Nat Commun. 2024 Feb 7;15(1):1169. doi: 10.1038/s41467-024-45382-0. PubMed |
| Tracing back primed resistance in cancer via sister cells. Dai J, Zheng S, Falco MM, Bao J, Eriksson J, Pikkusaari S, Forsten S, Jiang J, Wang W, Gao L, Perez-Villatoro F, Dufva O, Saeed K, Wang Y, Amiryousefi A, Farkkila A, Mustjoki S, Kauppi L, Tang J, Vaharautio A. Nat Commun. 2024 Feb 7;15(1):1158. doi: 10.1038/s41467-024-45478-7. PubMed |
| A small-molecule degrader selectively inhibits the growth of ALK-rearranged lung cancer with ceritinib resistance. Li X, Wang Z, Chen C, Yang F, Liu P, Fang S, Wang B, Chen S, Li X. iScience. 2024 Jan 26;27(2):109015. doi: 10.1016/j.isci.2024.109015. eCollection 2024 Feb 16. PubMed |
| A microglia clonal inflammatory disorder in Alzheimer's Disease. Vicario R, Fragkogianni S, Weber L, Lazarov T, Hu Y, Hayashi SY, Craddock BP, Socci ND, Alberdi A, Baako A, Ay O, Ogishi M, Lopez-Rodrigo E, Kappagantula R, Viale A, Iacobuzio-Donahue CA, Zhou T, Ransohoff RM, Chesworth R, Bank NB, Abdel-Wahab O, Boisson B, Elemento O, Casanova JL, Miller WT, Geissmann F. bioRxiv [Preprint]. 2024 Jan 25:2024.01.25.577216. doi: 10.1101/2024.01.25.577216. PubMed |
| Human vascular organoids with a mosaic AKT1 mutation recapitulate Proteus syndrome. He S, Zhu Y, Chauhan S, Tavakol DN, Lee JH, Berris RB, Xu C, Lee JH, Lee C, Cai S, McElroy S, Vunjak-Novakovic G, Tomer R, Azizi E, Xu B, Lao YH, Leong KW. bioRxiv [Preprint]. 2024 Jan 27:2024.01.26.577324. doi: 10.1101/2024.01.26.577324. PubMed |
| PREX1 improves homeostatic proliferation to maintain a naive CD4+ T cell compartment in older age. Zhang H, Okuyama H, Jain A, Jadhav RR, Wu B, Sturmlechner I, Morales J, Ohtsuki S, Weyand CM, Goronzy JJ. JCI Insight. 2024 Feb 8;9(5):e172848. doi: 10.1172/jci.insight.172848. PubMed |
| Preclinical evaluation of CRISPR-based therapies for Noonan syndrome caused by deep-intronic LZTR1 variants. Knauer C, Haltern H, Schoger E, Kugler S, Roos L, Zelarayan LC, Hasenfuss G, Zimmermann WH, Wollnik B, Cyganek L. Mol Ther Nucleic Acids. 2024 Jan 23;35(1):102123. doi: 10.1016/j.omtn.2024.102123. eCollection 2024 Mar 12. PubMed |
| Development of Chromosome 1q+ Specific Treatment for Highest Risk Pediatric Posterior Fossa Ependymoma. Griesinger AM, Calzadilla AJ, Grimaldo E, Donson AM, Amani V, Pierce AM, Steiner J, Kargar S, Serkova NJ, Bertrand KC, Wright KD, Vibhakar R, Hankinson T, Handler M, Lindsay HB, Foreman NK, Dorris K. Clin Cancer Res. 2024 Apr 15;30(8):1544-1554. doi: 10.1158/1078-0432.CCR-23-3156. PubMed |
| Sarcoma Cells Secrete Hypoxia-Modified Collagen VI to Weaken the Lung Endothelial Barrier and Promote Metastasis. Liu Y, Murazzi I, Fuller AM, Pan H, Irizarry-Negron VM, Devine A, Katti R, Skuli N, Ciotti GE, Pak K, Pack MA, Simon MC, Weber K, Cooper K, Eisinger-Mathason TSK. Cancer Res. 2024 Apr 1;84(7):977-993. doi: 10.1158/0008-5472.CAN-23-0910. PubMed |
Sequential CRISPR screening reveals partial NatB inhibition as a strategy to mitigate alpha-synuclein levels in human neurons.
Santhosh Kumar S, Naseri NN, Pather SR, Hallacli E, Ndayisaba A, Buenaventura C, Acosta K, Roof J, Fazelinia H, Spruce LA, Luk K, Khurana V, Rhoades E, Shalem O.
Sci Adv. 2024 Feb 9;10(6):eadj4767. doi: 10.1126/sciadv.adj4767. Epub 2024 Feb 9.
PubMed
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| Retrospective identification of cell-intrinsic factors that mark pluripotency potential in rare somatic cells. Jain N, Goyal Y, Dunagin MC, Cote CJ, Mellis IA, Emert B, Jiang CL, Dardani IP, Reffsin S, Arnett M, Yang W, Raj A. Cell Syst. 2024 Feb 21;15(2):109-133.e10. doi: 10.1016/j.cels.2024.01.001. Epub 2024 Feb 8. PubMed |
| NY-ESO-1-specific T cell receptor-engineered T cells and Tranilast, a TRPV2 antagonist bivalent treatment enhances the killing of esophageal cancer: a dual-targeted cancer therapeutic route. Amissah OB, Chen W, de Dieu Habimana J, Sun Y, Lin L, Liu Y, Wang L, Liu Z, Mukama O, Basnet R, Liu H, Li J, Ding X, Lv L, Chen M, Liang Y, Huang R, Li Z. Cancer Cell Int. 2024 Feb 9;24(1):64. doi: 10.1186/s12935-024-03249-w. PubMed |
| Involucrasin B Inhibits the Proliferation of Caco-2 Cells by Regulating the TGFbeta/SMAD2-3-4 Pathway. Wang Z, Lin W, Shi M, Hou Y, Liu J, Huang Z, Zhang X, Yang Y, Liu B, Yang Z, Ma W. Molecules. 2024 Feb 1;29(3):686. doi: 10.3390/molecules29030686. PubMed |
| Intercellular transfer of cancer cell invasiveness via endosome-mediated protease shedding. Wenzel EM, Pedersen NM, Elfmark LA, Wang L, Kjos I, Stang E, Malerod L, Brech A, Stenmark H, Raiborg C. Nat Commun. 2024 Feb 10;15(1):1277. doi: 10.1038/s41467-024-45558-8. PubMed |
| Schwann cell promotes macrophage recruitment through IL-17B/IL-17RB pathway in injured peripheral nerves. Huang Y, Wu L, Zhao Y, Guo J, Li R, Ma S, Ying Z. Cell Rep. 2024 Feb 27;43(2):113753. doi: 10.1016/j.celrep.2024.113753. Epub 2024 Feb 10. PubMed |
| Culture substrate stiffness impacts human myoblast contractility-dependent proliferation and nuclear envelope wrinkling. Nguyen J, Wang L, Lei W, Hu Y, Gulati N, Chavez-Madero C, Ahn H, Ginsberg HJ, Krawetz R, Brandt M, Betz T, Gilbert PM. J Cell Sci. 2024 Mar 15;137(6):jcs261666. doi: 10.1242/jcs.261666. Epub 2024 Mar 27. PubMed |
| Pharmacologic hyperstabilisation of the HIV-1 capsid lattice induces capsid failure. Faysal KMR, Walsh JC, Renner N, Marquez CL, Shah VB, Tuckwell AJ, Christie MP, Parker MW, Turville SG, Towers GJ, James LC, Jacques DA, Bocking T. Elife. 2024 Feb 13;13:e83605. doi: 10.7554/eLife.83605. PubMed |
| NS1-mediated enhancement of MVC transcription and replication promoted by KAT5/H4K12ac. Zhang X, Guo J, Xu H, Ding S, Liu L, Chen Z, Yang J, Liu Y, Hao H, Huang F, Qiu J, Guan W, Sun Y, Liu H. J Virol. 2024 Mar 19;98(3):e0169523. doi: 10.1128/jvi.01695-23. Epub 2024 Feb 13. PubMed |
| Discovery and characterization of anti-cancer peptides from a random peptide library. Puvvula PK, Moon AM. PLoS One. 2024 Feb 13;19(2):e0293072. doi: 10.1371/journal.pone.0293072. eCollection 2024. PubMed |
| Hyaluronic acid turnover controls the severity of cerebral cavernous malformations in bioengineered human micro-vessels. Yordanov TE, Keyser MS, Enriquez Martinez MA, Esposito T, Tefft JB, Morris EK, Labzin LI, Stehbens SJ, Rowan AE, Hogan BM, Chen CS, Lauko J, Lagendijk AK. APL Bioeng. 2024 Feb 12;8(1):016108. doi: 10.1063/5.0159330. eCollection 2024 Mar. PubMed |
| A programmable arthritis-specific receptor for guided articular cartilage regenerative medicine. Walton BL, Shattuck-Brandt R, Hamann CA, Tung VW, Colazo JM, Brand DD, Hasty KA, Duvall CL, Brunger JM. bioRxiv [Preprint]. 2024 Feb 15:2024.01.31.578281. doi: 10.1101/2024.01.31.578281. PubMed |
| Kinome-Wide Synthetic Lethal Screen Identifies PANK4 as a Modulator of Temozolomide Resistance in Glioblastoma. Vella V, Ditsiou A, Chalari A, Eravci M, Wooller SK, Gagliano T, Bani C, Kerschbamer E, Karakostas C, Xu B, Zhang Y, Pearl FMG, Lopez G, Peng L, Stebbing J, Klinakis A, Giamas G. Adv Sci (Weinh). 2024 Apr;11(15):e2306027. doi: 10.1002/advs.202306027. Epub 2024 Feb 14. PubMed |
| Local monomer levels and established filaments potentiate non-muscle myosin 2 assembly. Quintanilla MA, Patel H, Wu H, Sochacki KA, Chandrasekar S, Akamatsu M, Rotty JD, Korobova F, Bear JE, Taraska JW, Oakes PW, Beach JR. J Cell Biol. 2024 Apr 1;223(4):e202305023. doi: 10.1083/jcb.202305023. Epub 2024 Feb 14. PubMed |
| SP3-induced Timeless transcription contributes to cell growth of lung adenocarcinoma cells. Tian P, Du D, Yang L, Zhou N, Tao L. PLoS One. 2024 Feb 14;19(2):e0298295. doi: 10.1371/journal.pone.0298295. eCollection 2024. PubMed |
Uncovering receptor-ligand interactions using a high-avidity CRISPR activation screening platform.
Yang L, Sheets TP, Feng Y, Yu G, Bajgain P, Hsu KS, So D, Seaman S, Lee J, Lin L, Evans CN, Guest MR, Chari R, St Croix B.
Sci Adv. 2024 Feb 16;10(7):eadj2445. doi: 10.1126/sciadv.adj2445. Epub 2024 Feb 14.
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| Epigenetic regulation of CD38/CD48 by KDM6A mediates NK cell response in multiple myeloma. Liu J, Xing L, Li J, Wen K, Liu N, Liu Y, Wu G, Wang S, Ogiya D, Song TY, Kurata K, Penailillo J, Morelli E, Wang T, Hong X, Gulla A, Tai YT, Munshi N, Richardson P, Carrasco R, Hideshima T, Anderson KC. Nat Commun. 2024 Feb 14;15(1):1367. doi: 10.1038/s41467-024-45561-z. PubMed |
| Genetic determinants of micronucleus formation in vivo. Adams DJ, Barlas B, McIntyre RE, Salguero I, van der Weyden L, Barros A, Vicente JR, Karimpour N, Haider A, Ranzani M, Turner G, Thompson NA, Harle V, Olvera-Leon R, Robles-Espinoza CD, Speak AO, Geisler N, Weninger WJ, Geyer SH, Hewinson J, Karp NA, Fu B, Yang F, Kozik Z, Choudhary J, Yu L, van Ruiten MS, Rowland BD, Lelliott CJ, Del Castillo Velasco-Herrera M, Verstraten R, Bruckner L, Henssen AG, Rooimans MA, de Lange J, Mohun TJ, Arends MJ, Kentistou KA, Coelho PA, Zhao Y, Zecchini H, Perry JRB, Jackson SP, Balmus G. Nature. 2024 Mar;627(8002):130-136. doi: 10.1038/s41586-023-07009-0. Epub 2024 Feb 14. PubMed |
| Targeted inhibition of SCF(SKP2) confers anti-tumor activities resulting in a survival benefit in osteosarcoma. Wang J, Ferrena A, Zhang R, Singh S, Viscarret V, Al-Harden W, Aldahamsheh O, Borjihan H, Singla A, Yaguare S, Tingling J, Zi X, Lo Y, Gorlick R, Schwartz EL, Zhao H, Yang R, Geller DS, Zheng D, Hoang BH. Oncogene. 2024 Mar;43(13):962-975. doi: 10.1038/s41388-024-02942-4. Epub 2024 Feb 14. PubMed |
| Mesothelin Secretion by Pancreatic Cancer Cells Co-opts Macrophages and Promotes Metastasis. Luckett T, Abudula M, Ireland L, Glenn M, Bellomo G, Stafferton R, Halloran C, Ghaneh P, Jones R, Schmid MC, Mielgo A. Cancer Res. 2024 Feb 15;84(4):527-544. doi: 10.1158/0008-5472.CAN-23-1542. PubMed |
| TPX2 overexpression promotes sensitivity to dasatinib in breast cancer by activating YAP transcriptional signaling. Marugan C, Sanz-Gomez N, Ortigosa B, Monfort-Vengut A, Bertinetti C, Teijo A, Gonzalez M, Alonso de la Vega A, Lallena MJ, Moreno-Bueno G, de Carcer G. Mol Oncol. 2024 Jun;18(6):1531-1551. doi: 10.1002/1878-0261.13602. Epub 2024 Feb 15. PubMed |
| The phosphatidylinositol-5' phosphatase synaptojanin1 limits integrin-mediated invasion of Staphylococcus aureus. Shi Y, Muenzner P, Schanz-Jurinka S, Hauck CR. Microbiol Spectr. 2024 Apr 2;12(4):e0200623. doi: 10.1128/spectrum.02006-23. Epub 2024 Feb 15. PubMed |
| Clinical, immunohistochemical, and genetic characterization of splice-altering biallelic DES variants: Therapeutic implications. Geist Hauserman J, Laverty CG, Donkervoort S, Hu Y, Silverstein S, Neuhaus SB, Saade D, Vaughn G, Malicki D, Kaur R, Li Y, Luo Y, Liu P, Burr P, Foley AR, Mohassel P, Bonnemann CG. HGG Adv. 2024 Apr 11;5(2):100274. doi: 10.1016/j.xhgg.2024.100274. Epub 2024 Feb 2. PubMed |
| Experimental evidence for cancer resistance in a bat species. Hua R, Ma YS, Yang L, Hao JJ, Hua QY, Shi LY, Yao XQ, Zhi HY, Liu Z. Nat Commun. 2024 Feb 15;15(1):1401. doi: 10.1038/s41467-024-45767-1. PubMed |
| Shared and distinct mechanisms of UBA1 inactivation across different diseases. Collins JC, Magaziner SJ, English M, Hassan B, Chen X, Balanda N, Anderson M, Lam A, Fernandez-Pol S, Kwong B, Greenberg PL, Terrier B, Likhite ME, Kosmider O, Wang Y, Samara NL, Walters KJ, Beck DB, Werner A. EMBO J. 2024 May;43(10):1919-1946. doi: 10.1038/s44318-024-00046-z. Epub 2024 Feb 15. PubMed |
| Induction of stearoyl-CoA desaturase confers cell density-dependent ferroptosis resistance in melanoma. Shirahama H, Tani Y, Tsukahara S, Okamoto Y, Hasebe A, Noda T, Ando S, Ushijima M, Matsuura M, Tomida A. J Cell Biochem. 2024 Apr;125(4):e30542. doi: 10.1002/jcb.30542. Epub 2024 Feb 16. PubMed |
| Tsyn-Seq: a T-cell Synapse-Based Antigen Identification Platform. Jin Y, Miyama T, Brown A, Hayase T, Song X, Singh AK, Huang L, Flores II, McDaniel LK, Glover I, Halsey TM, Prasad R, Chapa V, Ahmed S, Zhang J, Rai K, Peterson CB, Lizee G, Karmouch J, Hayase E, Molldrem JJ, Chang CC, Tsai WB, Jenq RR. Cancer Immunol Res. 2024 May 2;12(5):530-543. doi: 10.1158/2326-6066.CIR-23-0467. PubMed |
| Stem-like progenitor and terminally differentiated T(FH)-like CD4(+) T cell exhaustion in the tumor microenvironment. Zhou W, Kawashima S, Ishino T, Kawase K, Ueda Y, Yamashita K, Watanabe T, Kawazu M, Dansako H, Suzuki Y, Nishikawa H, Inozume T, Nagasaki J, Togashi Y. Cell Rep. 2024 Feb 27;43(2):113797. doi: 10.1016/j.celrep.2024.113797. Epub 2024 Feb 15. PubMed |
| A regulatory element associated to NAFLD in the promoter of DIO1 controls LDL-C, HDL-C and triglycerides in hepatic cells. Castillejo-Lopez C, Barcenas-Walls JR, Cavalli M, Larsson A, Wadelius C. Lipids Health Dis. 2024 Feb 16;23(1):48. doi: 10.1186/s12944-024-02029-9. PubMed |
| PAF1c links S-phase progression to immune evasion and MYC function in pancreatic carcinoma. Gaballa A, Gebhardt-Wolf A, Krenz B, Mattavelli G, John M, Cossa G, Andreani S, Schulein-Volk C, Montesinos F, Vidal R, Kastner C, Ade CP, Kneitz B, Gasteiger G, Gallant P, Rosenfeldt M, Riedel A, Eilers M. Nat Commun. 2024 Feb 16;15(1):1446. doi: 10.1038/s41467-024-45760-8. PubMed |
| Characterization of enhancer activity in early human neurodevelopment using Massively Parallel Reporter Assay (MPRA) and forebrain organoids. Capauto D, Wang Y, Wu F, Norton S, Mariani J, Inoue F, Crawford GE, Ahituv N, Abyzov A, Vaccarino FM. Sci Rep. 2024 Feb 16;14(1):3936. doi: 10.1038/s41598-024-54302-7. PubMed |
| Tropomyosin1 isoforms underlie epithelial to mesenchymal plasticity, metastatic dissemination, and resistance to chemotherapy in high-grade serous ovarian cancer. Xu T, Verhagen MP, Teeuwssen M, Sun W, Joosten R, Sacchetti A, Ewing-Graham PC, Jansen MPHM, Boere IA, Bryce NS, Zeng J, Treutlein HR, Hook J, Hardeman EC, Gunning PW, Fodde R. Cell Death Differ. 2024 Mar;31(3):360-377. doi: 10.1038/s41418-024-01267-9. Epub 2024 Feb 16. PubMed |
| Combined therapy of CAR-IL-15/IL-15Ralpha-T cells and GLIPR1 knockdown in cancer cells enhanced anti-tumor effect against gastric cancer. Ye J, Liu Q, He Y, Song Z, Lin B, Hu Z, Hu J, Ning Y, Cai C, Li Y. J Transl Med. 2024 Feb 18;22(1):171. doi: 10.1186/s12967-024-04982-6. PubMed |
| A polyvalent RNA vaccine reduces the immune imprinting phenotype in mice and induces neutralizing antibodies against omicron SARS-CoV-2. Costa Rocha VP, Souza Machado BA, Barreto BC, Quadros HC, Santana Fernandes AM, Lima EDS, Bandeira ME, Meira CS, Moraes Dos Santos Fonseca L, Erasmus J, Khandhar A, Berglund P, Reed S, Jose da Silva Badaro R, Pereira Soares MB. Heliyon. 2024 Feb 6;10(4):e25539. doi: 10.1016/j.heliyon.2024.e25539. eCollection 2024 Feb 29. PubMed |
| Sparse CBX2 nucleates many Polycomb proteins to promote facultative heterochromatinization of Polycomb target genes. Ingersoll S, Trouth A, Luo X, Espinoza A, Wen J, Tucker J, Astatike K, Phiel CJ, Kutateladze TG, Wu TP, Ramachandran S, Ren X. bioRxiv [Preprint]. 2024 Feb 5:2024.02.05.578969. doi: 10.1101/2024.02.05.578969. PubMed |
| Persistent tailoring of MSC activation through genetic priming. Beauregard MA, Bedford GC, Brenner DA, Sanchez Solis LD, Nishiguchi T, Abhimanyu, Longlax SC, Mahata B, Veiseh O, Wenzel PL, DiNardo AR, Hilton IB, Diehl MR. bioRxiv [Preprint]. 2024 Feb 7:2024.02.01.578489. doi: 10.1101/2024.02.01.578489. PubMed |
| Epigenomic analyses identify FOXM1 as a key regulator of anti-tumor immune response in esophageal adenocarcinoma. Ziman B, Yang Q, Zheng Y, Sheth M, Nam C, Zhao H, Zhang L, Hu B, Bhowmick NA, Sinha UK, Lin DC. Cell Death Dis. 2024 Feb 19;15(2):152. doi: 10.1038/s41419-024-06488-x. PubMed |
| Structural basis for antibody recognition of the proximal MUC16 ectodomain. Lee K, Perry K, Xu M, Veillard I, Kumar R, Rao TD, Rueda BR, Spriggs DR, Yeku OO. J Ovarian Res. 2024 Feb 19;17(1):41. doi: 10.1186/s13048-024-01373-9. PubMed |
| PKCmu promotes keratinocyte cell migration through Cx43 phosphorylation-mediated suppression of intercellular communication. Pun R, Cavanaugh AM, Aldrich E, Tran O, Rudd JC, Hansen LA, North BJ. iScience. 2024 Jan 29;27(3):109033. doi: 10.1016/j.isci.2024.109033. eCollection 2024 Mar 15. PubMed |
| Host E3 ubiquitin ligase ITCH mediates Toxoplasma gondii effector GRA35-triggered NLRP1 inflammasome activation and cell-autonomous immunity. Wang Y, Hollingsworth LR, Sangare LO, Paredes-Santos TC, Krishnamurthy S, Penn BH, Wu H, Saeij JPJ. mBio. 2024 Mar 13;15(3):e0330223. doi: 10.1128/mbio.03302-23. Epub 2024 Feb 20. PubMed |
| The NP protein of Newcastle disease virus dictates its oncolytic activity by regulating viral mRNA translation efficiency. Liao T, Chen Y, Guo L, Zhu S, Zhan T, Lu X, Xu H, Hu Z, Hu J, Gu M, Liu X, Wang X, Hu S, Liu X. PLoS Pathog. 2024 Feb 20;20(2):e1012027. doi: 10.1371/journal.ppat.1012027. eCollection 2024 Feb. PubMed |
| Resistance of HNSCC cell models to pan-FGFR inhibition depends on the EMT phenotype associating with clinical outcome. Broghammer F, Korovina I, Gouda M, Celotti M, van Es J, Lange I, Brunner C, Mircetic J, Coppes RP, Gires O, Dahl A, Seifert M, Cordes N. Mol Cancer. 2024 Feb 21;23(1):39. doi: 10.1186/s12943-024-01954-8. PubMed |
| Chronic endoplasmic reticulum stress in myotonic dystrophy type 2 promotes autoimmunity via mitochondrial DNA release. Rosing S, Ullrich F, Meisterfeld S, Schmidt F, Mlitzko L, Croon M, Nattrass RG, Eberl N, Mahlberg J, Schlee M, Wieland A, Simon P, Hilbig D, Reuner U, Rapp A, Bremser J, Mirtschink P, Drukewitz S, Zillinger T, Beissert S, Paeschke K, Hartmann G, Trifunovic A, Bartok E, Gunther C. Nat Commun. 2024 Feb 20;15(1):1534. doi: 10.1038/s41467-024-45535-1. PubMed |
| The exocyst complex and intracellular vesicles mediate soluble protein trafficking to the primary cilium. Niedziolka SM, Datta S, Uspienski T, Baran B, Skarzynska W, Humke EW, Rohatgi R, Niewiadomski P. Commun Biol. 2024 Feb 21;7(1):213. doi: 10.1038/s42003-024-05817-2. PubMed |
| Endothelial lipase variant T111I does not alter inhibition by angiopoietin-like proteins. Sylvers-Davie KL, Bierstedt KC, Schnieders MJ, Davies BSJ. Sci Rep. 2024 Feb 20;14(1):4246. doi: 10.1038/s41598-024-54705-6. PubMed |
| Downregulation of praja2 restrains endocytosis and boosts tyrosine kinase receptors in kidney cancer. Rinaldi L, Chiuso F, Senatore E, Borzacchiello D, Lignitto L, Iannucci R, Donne RD, Fuggi M, Reale C, Russo F, Russo NA, Giurato G, Rizzo F, Sellitto A, Santangelo M, De Biase D, Paciello O, D'Ambrosio C, Amente S, Garbi C, Dalla E, Scaloni A, Weisz A, Ambrosino C, Insabato L, Feliciello A. Commun Biol. 2024 Feb 20;7(1):208. doi: 10.1038/s42003-024-05823-4. PubMed |
| The role of microRNA-325-3p as a critical player in cell death in NSCs and astrocytes. Lee Y, Lee SW, Jeong D, Lee HJ, Ko K. Front Cell Dev Biol. 2024 Jan 16;11:1223987. doi: 10.3389/fcell.2023.1223987. eCollection 2023. PubMed |
| Influence of RNA circularity on Target RNA-Directed MicroRNA Degradation. Fuchs Wightman F, Lukin J, Giusti SA, Soutschek M, Bragado L, Pozzi B, Pierelli ML, Gonzalez P, Fededa JP, Schratt G, Fujiwara R, Wilusz JE, Refojo D, de la Mata M. Nucleic Acids Res. 2024 Apr 12;52(6):3358-3374. doi: 10.1093/nar/gkae094. PubMed |
| Selective CDK7 Inhibition Suppresses Cell Cycle Progression and MYC Signaling While Enhancing Apoptosis in Therapy-resistant Estrogen Receptor-positive Breast Cancer. Guarducci C, Nardone A, Russo D, Nagy Z, Heraud C, Grinshpun A, Zhang Q, Freelander A, Leventhal MJ, Feit A, Cohen Feit G, Feiglin A, Liu W, Hermida-Prado F, Kesten N, Ma W, De Angelis C, Morlando A, O'Donnell M, Naumenko S, Huang S, Nguyen QD, Huang Y, Malorni L, Bergholz JS, Zhao JJ, Fraenkel E, Lim E, Schiff R, Shapiro GI, Jeselsohn R. Clin Cancer Res. 2024 May 1;30(9):1889-1905. doi: 10.1158/1078-0432.CCR-23-2975. PubMed |
| SRRM2 phase separation drives assembly of nuclear speckle subcompartments. Zhang M, Gu Z, Guo S, Sun Y, Ma S, Yang S, Guo J, Fang C, Shu L, Ge Y, Chen Z, Wang B. Cell Rep. 2024 Mar 26;43(3):113827. doi: 10.1016/j.celrep.2024.113827. Epub 2024 Feb 20. PubMed |
| Cullin-RING ligases employ geometrically optimized catalytic partners for substrate targeting. Li J, Purser N, Liwocha J, Scott DC, Byers HA, Steigenberger B, Hill S, Tripathi-Giesgen I, Hinkle T, Hansen FM, Prabu JR, Radhakrishnan SK, Kirkpatrick DS, Reichermeier KM, Schulman BA, Kleiger G. Mol Cell. 2024 Apr 4;84(7):1304-1320.e16. doi: 10.1016/j.molcel.2024.01.022. Epub 2024 Feb 20. PubMed |
| Thalamocortical organoids enable in vitro modeling of 22q11.2 microdeletion associated with neuropsychiatric disorders. Shin D, Kim CN, Ross J, Hennick KM, Wu SR, Paranjape N, Leonard R, Wang JC, Keefe MG, Pavlovic BJ, Donohue KC, Moreau C, Wigdor EM, Larson HH, Allen DE, Cadwell CR, Bhaduri A, Popova G, Bearden CE, Pollen AA, Jacquemont S, Sanders SJ, Haussler D, Wiita AP, Frost NA, Sohal VS, Nowakowski TJ. Cell Stem Cell. 2024 Mar 7;31(3):421-432.e8. doi: 10.1016/j.stem.2024.01.010. Epub 2024 Feb 20. PubMed |
Targeted protein degradation via intramolecular bivalent glues.
Hsia O, Hinterndorfer M, Cowan AD, Iso K, Ishida T, Sundaramoorthy R, Nakasone MA, Imrichova H, Schatz C, Rukavina A, Husnjak K, Wegner M, Correa-Saez A, Craigon C, Casement R, Maniaci C, Testa A, Kaulich M, Dikic I, Winter GE, Ciulli A.
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PubMed
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| Host ZCCHC3 blocks HIV-1 infection and production through a dual mechanism. Yi B, Tanaka YL, Cornish D, Kosako H, Butlertanaka EP, Sengupta P, Lippincott-Schwartz J, Hultquist JF, Saito A, Yoshimura SH. iScience. 2024 Feb 5;27(3):109107. doi: 10.1016/j.isci.2024.109107. eCollection 2024 Mar 15. PubMed |
A versatile CRISPR-Cas13d platform for multiplexed transcriptomic regulation and metabolic engineering in primary human T cells.
Tieu V, Sotillo E, Bjelajac JR, Chen C, Malipatlolla M, Guerrero JA, Xu P, Quinn PJ, Fisher C, Klysz D, Mackall CL, Qi LS.
Cell. 2024 Feb 29;187(5):1278-1295.e20. doi: 10.1016/j.cell.2024.01.035. Epub 2024 Feb 21.
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| CD73 mitigates ZEB1 expression in papillary thyroid carcinoma. Vedovatto S, Oliveira FD, Pereira LC, Scheffel TB, Beckenkamp LR, Bertoni APS, Wink MR, Lenz G. Cell Commun Signal. 2024 Feb 22;22(1):145. doi: 10.1186/s12964-024-01522-z. PubMed |
| Modeling the precise interaction of glioblastoma with human brain region-specific organoids. Fan Q, Wang H, Gu T, Liu H, Deng P, Li B, Yang H, Mao Y, Shao Z. iScience. 2024 Feb 5;27(3):109111. doi: 10.1016/j.isci.2024.109111. eCollection 2024 Mar 15. PubMed |
| Effect of hypoxia‑HIF‑1alpha‑periostin axis in thyroid cancer. Yang Y, Wu J, Zhu H, Shi X, Liu J, Li Y, Wang M. Oncol Rep. 2024 Apr;51(4):57. doi: 10.3892/or.2024.8716. Epub 2024 Feb 23. PubMed |
An engineered biosensor enables dynamic aspartate measurements in living cells.
Davidsen K, Marvin JS, Aggarwal A, Brown TA, Sullivan LB.
eLife. 2024 Feb 23;12:RP90024. doi: 10.7554/eLife.90024.
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| Therapeutic targeting Tudor domains in leukemia via CRISPR-Scan Assisted Drug Discovery. Chan AKN, Han L, Delaney CD, Wang X, Mukhaleva E, Li M, Yang L, Pokharel SP, Mattson N, Garcia M, Wang B, Xu X, Zhang L, Singh P, Elsayed Z, Chen R, Kuang B, Wang J, Yuan YC, Chen B, Chan LN, Rosen ST, Horne D, Muschen M, Chen J, Vaidehi N, Armstrong SA, Su R, Chen CW. Sci Adv. 2024 Feb 23;10(8):eadk3127. doi: 10.1126/sciadv.adk3127. Epub 2024 Feb 23. PubMed |
| Restoration of miR-299-3p promotes macrophage phagocytosis and suppresses malignant phenotypes in breast cancer carcinogenesis via dual-targeting CD47 and ABCE1. Tong S, Zhu Y, Leng Y, Wu Y, Xiao X, Zhao W, Tan S. Int Immunopharmacol. 2024 Mar 30;130:111708. doi: 10.1016/j.intimp.2024.111708. Epub 2024 Feb 22. PubMed |
| miR-147b mediated suppression of DUSP8 promotes lung cancer progression. Turkowski K, Herzberg F, Gunther S, Weigert A, Haselbauer T, Fink L, Brunn D, Grimminger F, Seeger W, Sultmann H, Stiewe T, Pullamsetti SS, Savai R. Oncogene. 2024 Apr;43(16):1178-1189. doi: 10.1038/s41388-024-02969-7. Epub 2024 Feb 23. PubMed |
| Shear Stress and the AMP-Activated Protein Kinase Independently Protect the Vascular Endothelium from Palmitate Lipotoxicity. Khapchaev AY, Vorotnikov AV, Antonova OA, Samsonov MV, Shestakova EA, Sklyanik IA, Tomilova AO, Shestakova MV, Shirinsky VP. Biomedicines. 2024 Feb 1;12(2):339. doi: 10.3390/biomedicines12020339. PubMed |
| Epigenetic Targeting to Overcome Radioresistance in Head and Neck Cancer. Schniewind I, Besso MJ, Klicker S, Schwarz FM, Hadiwikarta WW, Richter S, Lock S, Linge A, Krause M, Dubrovska A, Baumann M, Kurth I, Peitzsch C. Cancers (Basel). 2024 Feb 9;16(4):730. doi: 10.3390/cancers16040730. PubMed |
| ANLN Promotes the Proliferation and Migration of Gallbladder Cancer Cells via STRA6-Mediated Activation of PI3K/AKT Signaling. Zhu X, Zhang Y, Bian R, Zhu J, Shi W, Ye Y. Cancers (Basel). 2024 Feb 11;16(4):752. doi: 10.3390/cancers16040752. PubMed |
| The Nitro Group Reshapes the Effects of Pyrido[3,4-g]quinazoline Derivatives on DYRK/CLK Activity and RNA Splicing in Glioblastoma Cells. Borisevich SS, Aksinina TE, Ilyina MG, Shender VO, Anufrieva KS, Arapidi GP, Antipova NV, Anizon F, Esvan YJ, Giraud F, Tatarskiy VV, Moreau P, Shakhparonov MI, Pavlyukov MS, Shtil AA. Cancers (Basel). 2024 Feb 19;16(4):834. doi: 10.3390/cancers16040834. PubMed |
| Polypyrimidine tract-binding protein 3/insulin-like growth factor 2 mRNA-binding proteins 3/high-mobility group A1 axis promotes renal cancer growth and metastasis. Wang Q, Chen F, He Y, Gao Y, Wang J, Chu S, Xie P, Zhong J, Shan H, Bai J, Hou P. iScience. 2024 Feb 9;27(3):109158. doi: 10.1016/j.isci.2024.109158. eCollection 2024 Mar 15. PubMed |
| NOTUM-MEDIATED WNT SILENCING DRIVES EXTRAVILLOUS TROPHOBLAST CELL LINEAGE DEVELOPMENT. Shukla V, Moreno-Irusta A, Varberg KM, Kuna M, Iqbal K, Galligos AM, Aplin JD, Choudhury RH, Okae H, Arima T, Soares MJ. bioRxiv [Preprint]. 2024 Feb 14:2024.02.13.579974. doi: 10.1101/2024.02.13.579974. PubMed |
| Scalable and Efficient Generation of Mouse Primordial Germ Cell-like Cells. Ding X, Li L, Gao J, Yi D, Schimenti JC. bioRxiv [Preprint]. 2024 Feb 15:2024.02.15.580543. doi: 10.1101/2024.02.15.580543. PubMed |
| Metformin reduces the clonal fitness of Dnmt3a(R878H) hematopoietic stem and progenitor cells by reversing their aberrant metabolic and epigenetic state. Hosseini M, Voisin V, Chegini A, Varesi A, Cathelin S, Ayyathan DM, Liu ACH, Yang Y, Wang V, Maher A, Grignano E, Reisz JA, D'Alessandro A, Young K, Wu Y, Fiumara M, Ferrari S, Naldini L, Gaiti F, Pai S, Schimmer AD, Bader GD, Dick JE, Xie SZ, Trowbridge JJ, Chan SM. Res Sq [Preprint]. 2024 Feb 6:rs.3.rs-3874821. doi: 10.21203/rs.3.rs-3874821/v1. PubMed |
| KDM6A Regulates Immune Response Genes in Multiple Myeloma. Dupere-Richer D, Riva A, Maji S, Barwick BG, Roman HC, Sobh A, Quickstad G, Li J, De U, Piper C, Kulis M, Ezponda T, Martin-Subero JI, Tonon G, Zhang W, Mitsiades CS, Boise LH, Bennett RL, Licht JD. bioRxiv [Preprint]. 2024 Feb 12:2024.02.12.579179. doi: 10.1101/2024.02.12.579179. PubMed |
| Translational response to mitochondrial stresses is orchestrated by tRNA modifications. Rashad S, Al-Mesitef S, Mousa A, Zhou Y, Ando D, Sun G, Fukuuchi T, Iwasaki Y, Xiang J, Byrne SR, Sun J, Maekawa M, Saigusa D, Begley TJ, Dedon PC, Niizuma K. bioRxiv [Preprint]. 2024 Feb 14:2024.02.14.580389. doi: 10.1101/2024.02.14.580389. PubMed |
| Targeting autophagy overcomes cancer-intrinsic resistance to CAR-T immunotherapy in B-cell malignancies. Tang L, Zhang H, Zhou F, Wei Q, Du M, Wu J, Li C, Luo W, Zhou J, Wang X, Chen Z, Zhang Y, Huang Z, Wu Z, Wen Y, Jiang H, Liao D, Kou H, Xiong W, Mei H, Hu Y. Cancer Commun (Lond). 2024 Mar;44(3):408-432. doi: 10.1002/cac2.12525. Epub 2024 Feb 26. PubMed |
| Human transferrin receptor can mediate SARS-CoV-2 infection. Liao Z, Wang C, Tang X, Yang M, Duan Z, Liu L, Lu S, Ma L, Cheng R, Wang G, Liu H, Yang S, Xu J, Tadese DA, Mwangi J, Kamau PM, Zhang Z, Yang L, Liao G, Zhao X, Peng X, Lai R. Proc Natl Acad Sci U S A. 2024 Mar 5;121(10):e2317026121. doi: 10.1073/pnas.2317026121. Epub 2024 Feb 26. PubMed |
| The ubiquitin ligase HUWE1 enhances WNT signaling by antagonizing destruction complex-mediated beta-catenin degradation and through a mechanism independent of beta-catenin stability. McKenna JK, Wu Y, Sonkusre P, Chari R, Lebensohn AM. bioRxiv [Preprint]. 2024 Mar 17:2024.02.02.578552. doi: 10.1101/2024.02.02.578552. PubMed |
| ACKR3 Proximity Labeling Identifies Novel G protein- and beta-arrestin-independent GPCR Interacting Proteins. Hicks C, Gardner J, Eiger DS, Camarda ND, Pham U, Dhar S, Rodriguez H, Chundi A, Rajagopal S. bioRxiv [Preprint]. 2024 Jan 28:2024.01.27.577545. doi: 10.1101/2024.01.27.577545. PubMed |
Framework for in vivo T cell screens.
Milling LE, Markson SC, Tjokrosurjo Q, Derosia NM, Streeter ISL, Hickok GH, Lemmen AM, Nguyen TH, Prathima P, Fithian W, Schwartz MA, Hacohen N, Doench JG, LaFleur MW, Sharpe AH.
J Exp Med. 2024 Apr 1;221(4):e20230699. doi: 10.1084/jem.20230699. Epub 2024 Feb 27.
PubMed
Associated Plasmids |
| An EBV-related CD4 TCR immunotherapy inhibits tumor growth in an HLA-DP5+ nasopharyngeal cancer mouse model. Wang C, Chen J, Li J, Xu Z, Huang L, Zhao Q, Chen L, Liang X, Hu H, Li G, Xiong C, Wu B, You H, Du D, Wang X, Li H, Wang Z, Chen L. J Clin Invest. 2024 Feb 27;134(8):e172092. doi: 10.1172/JCI172092. PubMed |
Direct interrogation of context-dependent GPCR activity with a universal biosensor platform.
Janicot R, Maziarz M, Park JC, Zhao J, Luebbers A, Green E, Philibert CE, Zhang H, Layne MD, Wu JC, Garcia-Marcos M.
Cell. 2024 Feb 16:S0092-8674(24)00065-5. doi: 10.1016/j.cell.2024.01.028.
PubMed
Associated Plasmids |
| AF1q is a universal marker of neuroblastoma that sustains N-Myc expression and drives tumorigenesis. Oskouian B, Lee JY, Asgharzadeh S, Khan R, Zhang M, Weisbrod JR, Choi YJ, Puri L, Aguilar AE, Zhao P, Saba JD. Oncogene. 2024 Apr;43(16):1203-1213. doi: 10.1038/s41388-024-02980-y. Epub 2024 Feb 27. PubMed |
| NOVA1 acts as an oncogenic RNA-binding protein to regulate cholesterol homeostasis in human glioblastoma cells. Saito Y, Yang Y, Saito M, Park CY, Funato K, Tabar V, Darnell RB. Proc Natl Acad Sci U S A. 2024 Mar 5;121(10):e2314695121. doi: 10.1073/pnas.2314695121. Epub 2024 Feb 28. PubMed |
| Bile Acid Metabolism Mediates Cholesterol Homeostasis and Promotes Tumorigenesis in Clear Cell Renal Cell Carcinoma. Riscal R, Gardner SM, Coffey NJ, Carens M, Mesaros C, Xu JP, Xue Y, Davis L, Demczyszyn S, Vogt A, Olia A, Finan JM, Godfrey J, Schultz DC, Blair IA, Keith B, Marmorstein R, Skuli N, Simon MC. Cancer Res. 2024 May 15;84(10):1570-1582. doi: 10.1158/0008-5472.CAN-23-0821. PubMed |
| Hypoxia-induced immortalization of primary cells depends on Tfcp2L1 expression. Otero-Albiol D, Santos-Pereira JM, Lucena-Cacace A, Clemente-Gonzalez C, Munoz-Galvan S, Yoshida Y, Carnero A. Cell Death Dis. 2024 Feb 28;15(2):177. doi: 10.1038/s41419-024-06567-z. PubMed |
| PB2 residue 473 contributes to the mammalian virulence of H7N9 avian influenza virus by modulating viral polymerase activity via ANP32A. Zhang M, Liu M, Chen H, Qiu T, Jin X, Fu W, Teng Q, Zhao C, Xu J, Li Z, Zhang X. J Virol. 2024 Mar 19;98(3):e0194423. doi: 10.1128/jvi.01944-23. Epub 2024 Feb 29. PubMed |
| The SARS-CoV-2 Spike is a virulence determinant and plays a major role on the attenuated phenotype of Omicron virus in a feline model of infection. Martins M, Nooruzzaman M, Cunningham JL, Ye C, Caserta LC, Jackson N, Martinez-Sobrido L, Fang Y, Diel DG. J Virol. 2024 Mar 19;98(3):e0190223. doi: 10.1128/jvi.01902-23. Epub 2024 Feb 29. PubMed |
| Sensory nerve release of CGRP increases tumor growth in HNSCC by suppressing TILs. Darragh LB, Nguyen A, Pham TT, Idlett-Ali S, Knitz MW, Gadwa J, Bukkapatnam S, Corbo S, Olimpo NA, Nguyen D, Van Court B, Neupert B, Yu J, Ross RB, Corbisiero M, Abdelazeem KNM, Maroney SP, Galindo DC, Mukdad L, Saviola A, Joshi M, White R, Alhiyari Y, Samedi V, Van Bokhoven A, St John M, Karam SD. Med. 2024 Mar 8;5(3):254-270.e8. doi: 10.1016/j.medj.2024.02.002. Epub 2024 Feb 28. PubMed |
| The proteomic landscape of genotoxic stress-induced micronuclei. MacDonald KM, Khan S, Lin B, Hurren R, Schimmer AD, Kislinger T, Harding SM. Mol Cell. 2024 Apr 4;84(7):1377-1391.e6. doi: 10.1016/j.molcel.2024.02.001. Epub 2024 Feb 28. PubMed |
| OrthoID: profiling dynamic proteomes through time and space using mutually orthogonal chemical tools. Lee A, Sung G, Shin S, Lee SY, Sim J, Nhung TTM, Nghi TD, Park SK, Sathieshkumar PP, Kang I, Mun JY, Kim JS, Rhee HW, Park KM, Kim K. Nat Commun. 2024 Feb 29;15(1):1851. doi: 10.1038/s41467-024-46034-z. PubMed |
| Advanced glycation end products promote meniscal calcification by activating the mTOR-ATF4 positive feedback loop. Yang S, Xie J, Pan Z, Guan H, Tu Y, Ye Y, Huang S, Fu S, Li K, Huang Z, Li X, Shi Z, Li L, Zhang Y. Exp Mol Med. 2024 Mar;56(3):630-645. doi: 10.1038/s12276-024-01190-6. Epub 2024 Mar 1. PubMed |
| CAMSAPs and nucleation-promoting factors control microtubule release from gamma-TuRC. Rai D, Song Y, Hua S, Stecker K, Monster JL, Yin V, Stucchi R, Xu Y, Zhang Y, Chen F, Katrukha EA, Altelaar M, Heck AJR, Wieczorek M, Jiang K, Akhmanova A. Nat Cell Biol. 2024 Mar;26(3):404-420. doi: 10.1038/s41556-024-01366-2. Epub 2024 Feb 29. PubMed |
| A common cellular response to broad splicing perturbations is characterized by metabolic transcript downregulation driven by the Mdm2-p53 axis. Varineau JE, Calo E. Dis Model Mech. 2024 Feb 1;17(2):dmm050356. doi: 10.1242/dmm.050356. Epub 2024 Mar 1. PubMed |
| Stromal Pbrm1 mediates chromatin remodeling necessary for embryo implantation in the mouse uterus. Xin Q, Feng I, Yu G, Dean J. J Clin Invest. 2024 Mar 1;134(5):e174194. doi: 10.1172/JCI174194. PubMed |
| Interferon lambda restricts herpes simplex virus skin disease by suppressing neutrophil-mediated pathology. Philip DT, Goins NM, Catanzaro NJ, Misumi I, Whitmire JK, Atkins HM, Lazear HM. mBio. 2024 Apr 10;15(4):e0262323. doi: 10.1128/mbio.02623-23. Epub 2024 Mar 1. PubMed |
| Coculture with macrophages alters ferroptosis susceptibility of triple-negative cancer cells. Konishi H, Haga Y, Okumura M, Tsujino H, Higashisaka K, Tsutsumi Y. Cell Death Discov. 2024 Mar 1;10(1):108. doi: 10.1038/s41420-024-01884-w. PubMed |
Combinatorial selective ER-phagy remodels the ER during neurogenesis.
Hoyer MJ, Capitanio C, Smith IR, Paoli JC, Bieber A, Jiang Y, Paulo JA, Gonzalez-Lozano MA, Baumeister W, Wilfling F, Schulman BA, Harper JW.
Nat Cell Biol. 2024 Mar;26(3):378-392. doi: 10.1038/s41556-024-01356-4. Epub 2024 Mar 1.
PubMed
Associated Plasmids |
| Fatty acid-binding proteins 3, 7, and 8 bind cholesterol and facilitate its egress from lysosomes. Fang XX, Wei P, Zhao K, Sheng ZC, Song BL, Yin L, Luo J. J Cell Biol. 2024 Apr 1;223(4):e202211062. doi: 10.1083/jcb.202211062. Epub 2024 Mar 1. PubMed |
| RTF2 controls replication repriming and ribonucleotide excision at the replisome. Conti BA, Ruiz PD, Broton C, Blobel NJ, Kottemann MC, Sridhar S, Lach FP, Wiley TF, Sasi NK, Carroll T, Smogorzewska A. Nat Commun. 2024 Mar 2;15(1):1943. doi: 10.1038/s41467-024-45947-z. PubMed |
| Human paraneoplastic antigen Ma2 (PNMA2) forms icosahedral capsids that can be engineered for mRNA delivery. Madigan V, Zhang Y, Raghavan R, Wilkinson ME, Faure G, Puccio E, Segel M, Lash B, Macrae RK, Zhang F. Proc Natl Acad Sci U S A. 2024 Mar 12;121(11):e2307812120. doi: 10.1073/pnas.2307812120. Epub 2024 Mar 4. PubMed |
| Trans-lesion synthesis and mismatch repair pathway crosstalk defines chemoresistance and hypermutation mechanisms in glioblastoma. Cheng X, An J, Lou J, Gu Q, Ding W, Droby GN, Wang Y, Wang C, Gao Y, Anand JR, Shelton A, Satterlee AB, Mann B, Hsiao YC, Liu CW, Lu K, Hingtgen S, Wang J, Liu Z, Miller CR, Wu D, Vaziri C, Yang Y. Nat Commun. 2024 Mar 4;15(1):1957. doi: 10.1038/s41467-024-45979-5. PubMed |
| Development and application of an indirect ELISA for detection of antibodies against emerging atypical porcine pestivirus. Song H, Gao X, Li J, Dong X, Fu Y, Shao L, Zhang J, Qiu HJ, Luo Y. Virol J. 2024 Mar 4;21(1):53. doi: 10.1186/s12985-024-02330-0. PubMed |
| Comparative analysis of human, rodent and snake deltavirus replication. Khalfi P, Denis Z, McKellar J, Merolla G, Chavey C, Ursic-Bedoya J, Soppa L, Szirovicza L, Hetzel U, Dufourt J, Leyrat C, Goldmann N, Goto K, Verrier E, Baumert TF, Glebe D, Courgnaud V, Gregoire D, Hepojoki J, Majzoub K. PLoS Pathog. 2024 Mar 5;20(3):e1012060. doi: 10.1371/journal.ppat.1012060. eCollection 2024 Mar. PubMed |
| ABCG2 transporter reduces protein aggregation in cigarette smoke condensate-exposed A549 lung cancer cells. Ajenu EO, Seideneck AM, Pandellapalli E, Shinsky EM, Humphries CL, Aparicio NL, Sharma M, Marden JH, Krasilnikova MM. PLoS One. 2024 Mar 5;19(3):e0297661. doi: 10.1371/journal.pone.0297661. eCollection 2024. PubMed |
| OSGN-1 is a conserved flavin-containing monooxygenase required to stabilize the intercellular bridge in late cytokinesis. Goupil E, Lacroix L, Briere J, Guga S, Saba-El-Leil MK, Meloche S, Labbe JC. Proc Natl Acad Sci U S A. 2024 Mar 12;121(11):e2308570121. doi: 10.1073/pnas.2308570121. Epub 2024 Mar 5. PubMed |
| eEF1A2 promotes PTEN-GSK3beta-SCF complex-dependent degradation of Aurora kinase A and is inactivated in breast cancer. Treekitkarnmongkol W, Solis LM, Sankaran D, Gagea M, Singh PK, Mistry R, Nguyen T, Kai K, Liu J, Sasai K, Jitsumori Y, Liu J, Nagao N, Stossi F, Mancini MA, Wistuba II, Thompson AM, Lee JM, Cadinanos J, Wong KK, Abbott CM, Sahin AA, Liu S, Katayama H, Sen S. Sci Signal. 2024 Mar 5;17(826):eadh4475. doi: 10.1126/scisignal.adh4475. Epub 2024 Mar 5. PubMed |
| Lactate dehydrogenase A regulates tumor-macrophage symbiosis to promote glioblastoma progression. Khan F, Lin Y, Ali H, Pang L, Dunterman M, Hsu WH, Frenis K, Grant Rowe R, Wainwright DA, McCortney K, Billingham LK, Miska J, Horbinski C, Lesniak MS, Chen P. Nat Commun. 2024 Mar 5;15(1):1987. doi: 10.1038/s41467-024-46193-z. PubMed |
| Neuronal miR-9 promotes HSV-1 epigenetic silencing and latency by repressing Oct-1 and Onecut family genes. Deng Y, Lin Y, Chen S, Xiang Y, Chen H, Qi S, Oh HS, Das B, Komazin-Meredith G, Pesola JM, Knipe DM, Coen DM, Pan D. Nat Commun. 2024 Mar 5;15(1):1991. doi: 10.1038/s41467-024-46057-6. PubMed |
| ALKBH5-mediated m6A modification of IL-11 drives macrophage-to-myofibroblast transition and pathological cardiac fibrosis in mice. Zhuang T, Chen MH, Wu RX, Wang J, Hu XD, Meng T, Wu AH, Li Y, Yang YF, Lei Y, Hu DH, Li YX, Zhang L, Sun AJ, Lu W, Zhang GN, Zuo JL, Ruan CC. Nat Commun. 2024 Mar 5;15(1):1995. doi: 10.1038/s41467-024-46357-x. PubMed |
| A deep learning model of tumor cell architecture elucidates response and resistance to CDK4/6 inhibitors. Park S, Silva E, Singhal A, Kelly MR, Licon K, Panagiotou I, Fogg C, Fong S, Lee JJY, Zhao X, Bachelder R, Parker BA, Yeung KT, Ideker T. Nat Cancer. 2024 Jul;5(7):996-1009. doi: 10.1038/s43018-024-00740-1. Epub 2024 Mar 5. PubMed |
| Non-cytopathic bovine viral diarrhea virus (BVDV) inhibits innate immune responses via induction of mitophagy. Li Z, Zhang Y, Zhao B, Xue Q, Wang C, Wan S, Wang J, Chen X, Qi X. Vet Res. 2024 Mar 5;55(1):27. doi: 10.1186/s13567-024-01284-z. PubMed |
| KLF7 regulates super-enhancer-driven IGF2BP2 overexpression to promote the progression of head and neck squamous cell carcinoma. Cai H, Liang J, Jiang Y, Wang Z, Li H, Wang W, Wang C, Hou J. J Exp Clin Cancer Res. 2024 Mar 5;43(1):69. doi: 10.1186/s13046-024-02996-y. PubMed |
| D-2-HG Inhibits IDH1mut Glioma Growth via FTO Inhibition and Resultant m6A Hypermethylation. Pianka ST, Li T, Prins TJ, Eldred BSC, Kevan BM, Liang H, Zapanta Rinonos S, Kornblum HI, Nathanson DA, Pellegrini M, Liau LM, Nghiemphu PL, Cloughesy TF, Lai A. Cancer Res Commun. 2024 Mar 22;4(3):876-894. doi: 10.1158/2767-9764.CRC-23-0271. PubMed |
| Atlas of cardiac endothelial cell enhancer elements linking the mineralocorticoid receptor to pathological gene expression. Deng L, Pollmeier L, Bednarz R, Cao C, Laurette P, Wirth L, Mamazhakypov A, Bode C, Hein L, Gilsbach R, Lother A. Sci Adv. 2024 Mar 8;10(10):eadj5101. doi: 10.1126/sciadv.adj5101. Epub 2024 Mar 6. PubMed |
| Urolithin A Hijacks ERK1/2-ULK1 Cascade to Improve CD8(+) T Cell Fitness for Antitumor Immunity. Ma S, Wu Q, Wu W, Tian Y, Zhang J, Chen C, Sheng X, Zhao F, Ding L, Wang T, Zhao L, Xie Y, Wang Y, Yue X, Wu Z, Wei J, Zhang K, Liang X, Gao L, Wang H, Wang G, Li C, Ma C. Adv Sci (Weinh). 2024 May;11(18):e2310065. doi: 10.1002/advs.202310065. Epub 2024 Mar 6. PubMed |
| Interplay Between Intracellular Transport Dynamics and Liquid‒Liquid Phase Separation. Zhang ML, Zhang Z, Niu XZ, Ti HY, Zhou YX, Gao B, Li Y, Liu JL, Chen X, Li H. Adv Sci (Weinh). 2024 May;11(19):e2308338. doi: 10.1002/advs.202308338. Epub 2024 Mar 6. PubMed |
| Engagement of sialylated glycans with Siglec receptors on suppressive myeloid cells inhibits anticancer immunity via CCL2. Wieboldt R, Sandholzer M, Carlini E, Lin CW, Borsch A, Zingg A, Lardinois D, Herzig P, Don L, Zippelius A, Laubli H, Mantuano NR. Cell Mol Immunol. 2024 May;21(5):495-509. doi: 10.1038/s41423-024-01142-0. Epub 2024 Mar 6. PubMed |
| Histone H2A variant H2A.B is enriched in transcriptionally active and replicating HSV-1 lytic chromatin. Flores Cortes E, Saddoris SM, Owens AK, Gibeault R, Depledge DP, Schang LM. J Virol. 2024 Apr 16;98(4):e0201523. doi: 10.1128/jvi.02015-23. Epub 2024 Mar 7. PubMed |
| FAM81A is a postsynaptic protein that regulates the condensation of postsynaptic proteins via liquid-liquid phase separation. Kaizuka T, Hirouchi T, Saneyoshi T, Shirafuji T, Collins MO, Grant SGN, Hayashi Y, Takumi T. PLoS Biol. 2024 Mar 7;22(3):e3002006. doi: 10.1371/journal.pbio.3002006. eCollection 2024 Mar. PubMed |
| CRISPR/Cas9 model of prostate cancer identifies Kmt2c deficiency as a metastatic driver by Odam/Cabs1 gene cluster expression. Cai H, Zhang B, Ahrenfeldt J, Joseph JV, Riedel M, Gao Z, Thomsen SK, Christensen DS, Bak RO, Hager H, Vendelbo MH, Gao X, Birkbak N, Thomsen MK. Nat Commun. 2024 Mar 7;15(1):2088. doi: 10.1038/s41467-024-46370-0. PubMed |
| In vivo genome-wide CRISPR screening identifies CITED2 as a driver of prostate cancer bone metastasis. Arriaga JM, Ronaldson-Bouchard K, Picech F, Nunes de Almeida F, Afari S, Chhouri H, Vunjak-Novakovic G, Abate-Shen C. Oncogene. 2024 Apr;43(17):1303-1315. doi: 10.1038/s41388-024-02995-5. Epub 2024 Mar 7. PubMed |
| S100A9(+)CD14(+) monocytes contribute to anti-PD-1 immunotherapy resistance in advanced hepatocellular carcinoma by attenuating T cell-mediated antitumor function. Tu X, Chen L, Zheng Y, Mu C, Zhang Z, Wang F, Ren Y, Duan Y, Zhang H, Tong Z, Liu L, Sun X, Zhao P, Wang L, Feng X, Fang W, Liu X. J Exp Clin Cancer Res. 2024 Mar 8;43(1):72. doi: 10.1186/s13046-024-02985-1. PubMed |
| Human papillomavirus-16 E6 activates the pentose phosphate pathway to promote cervical cancer cell proliferation by inhibiting G6PD lactylation. Meng Q, Zhang Y, Sun H, Yang X, Hao S, Liu B, Zhou H, Wang Y, Xu ZX. Redox Biol. 2024 May;71:103108. doi: 10.1016/j.redox.2024.103108. Epub 2024 Mar 1. PubMed |
| SMARCA4 is a haploinsufficient B cell lymphoma tumor suppressor that fine-tunes centrocyte cell fate decisions. Deng Q, Lakra P, Gou P, Yang H, Meydan C, Teater M, Chin C, Zhang W, Dinh T, Hussein U, Li X, Rojas E, Liu W, Reville PK, Kizhakeyil A, Barisic D, Parsons S, Wilson A, Henderson J, Scull B, Gurumurthy C, Vega F, Chadburn A, Cuglievan B, El-Mallawany NK, Allen C, Mason C, Melnick A, Green MR. Cancer Cell. 2024 Apr 8;42(4):605-622.e11. doi: 10.1016/j.ccell.2024.02.011. Epub 2024 Mar 7. PubMed |
| Adipose tissue peroxisomal lipid synthesis orchestrates obesity and insulin resistance through LXR-dependent lipogenesis. Kleiboeker B, He A, Tan M, Lu D, Hu D, Liu X, Goodarzi P, Hsu FF, Razani B, Semenkovich CF, Lodhi IJ. Mol Metab. 2024 Apr;82:101913. doi: 10.1016/j.molmet.2024.101913. Epub 2024 Mar 7. PubMed |
| Activity-dependent compartmentalization of dendritic mitochondria morphology through local regulation of fusion-fission balance in neurons in vivo. Virga DM, Hamilton S, Osei B, Morgan A, Kneis P, Zamponi E, Park NJ, Hewitt VL, Zhang D, Gonzalez KC, Russell FM, Grahame Hardie D, Prudent J, Bloss E, Losonczy A, Polleux F, Lewis TL Jr. Nat Commun. 2024 Mar 8;15(1):2142. doi: 10.1038/s41467-024-46463-w. PubMed |
An optogenetic method for the controlled release of single molecules.
Kashyap P, Bertelli S, Cao F, Kostritskaia Y, Blank F, Srikanth NA, Schlack-Leigers C, Saleppico R, Bierhuizen D, Lu X, Nickel W, Campbell RE, Plested AJR, Stauber T, Taylor MJ, Ewers H.
Nat Methods. 2024 Mar 8. doi: 10.1038/s41592-024-02204-x.
PubMed
Associated Plasmids |
| PRMT1 promotes pancreatic cancer development and resistance to chemotherapy. Ku B, Eisenbarth D, Baek S, Jeong TK, Kang JG, Hwang D, Noh MG, Choi C, Choi S, Seol T, Kim H, Kim YH, Woo SM, Kong SY, Lim DS. Cell Rep Med. 2024 Mar 19;5(3):101461. doi: 10.1016/j.xcrm.2024.101461. Epub 2024 Mar 8. PubMed |
| Roflumilast inhibits tumor growth and migration in STK11/LKB1 deficient pancreatic cancer. Zhang S, Yun D, Yang H, Eckstein M, Elbait GD, Zhou Y, Lu Y, Yang H, Zhang J, Dorflein I, Britzen-Laurent N, Pfeffer S, Stemmler MP, Dahl A, Mukhopadhyay D, Chang D, He H, Zeng S, Lan B, Frey B, Hampel C, Lentsch E, Gollavilli PN, Buttner C, Ekici AB, Biankin A, Schneider-Stock R, Ceppi P, Grutzmann R, Pilarsky C. Cell Death Discov. 2024 Mar 9;10(1):124. doi: 10.1038/s41420-024-01890-y. PubMed |
| FLI1 induces erythroleukemia through opposing effects on UBASH3A and UBASH3B expression. Wang J, Wang C, Hu A, Yu K, Kuang Y, Gajendran B, Zacksenhaus E, Sample KM, Xiao X, Liu W, Ben-David Y. BMC Cancer. 2024 Mar 9;24(1):326. doi: 10.1186/s12885-024-12075-2. PubMed |
| Novel meriolin derivatives activate the mitochondrial apoptosis pathway in the presence of antiapoptotic Bcl-2. Schmitt L, Lechtenberg I, Driessen D, Flores-Romero H, Skowron MA, Sekeres M, Hoppe J, Krings KS, Llewellyn TR, Peter C, Stork B, Qin N, Bhatia S, Nettersheim D, Fritz G, Garcia-Saez AJ, Muller TJJ, Wesselborg S. Cell Death Discov. 2024 Mar 9;10(1):125. doi: 10.1038/s41420-024-01901-y. PubMed |
| Mi-2beta promotes immune evasion in melanoma by activating EZH2 methylation. Li C, Wang Z, Yao L, Lin X, Jian Y, Li Y, Zhang J, Shao J, Tran PD, Hagman JR, Cao M, Cong Y, Li HY, Goding CR, Xu ZX, Liao X, Miao X, Cui R. Nat Commun. 2024 Mar 9;15(1):2163. doi: 10.1038/s41467-024-46422-5. PubMed |
| Suppressing APOE4-induced mortality and cellular damage by targeting VHL. Jiang WI, Cao Y, Xue Y, Ji Y, Winer BY, Zhang M, Singhal NS, Pierce JT, Chen S, Ma DK. bioRxiv [Preprint]. 2024 May 10:2024.02.28.582664. doi: 10.1101/2024.02.28.582664. PubMed |
| (13)C-SpaceM: Spatial single-cell isotope tracing reveals heterogeneity of de novo fatty acid synthesis in cancer. Buglakova E, Ekelof M, Schwaiger-Haber M, Schlicker L, Molenaar MR, Mohammed S, Stuart L, Eisenbarth A, Hilsenstein V, Patti GJ, Schulze A, Snaebjornsson MT, Alexandrov T. bioRxiv [Preprint]. 2024 Feb 28:2023.08.18.553810. doi: 10.1101/2023.08.18.553810. PubMed |
| A temperature-inducible protein module for control of mammalian cell fate. Benman W, Huang Z, Iyengar P, Wilde D, Mumford TR, Bugaj LJ. bioRxiv [Preprint]. 2024 Feb 19:2024.02.19.581019. doi: 10.1101/2024.02.19.581019. PubMed |
| PTEN loss in glioma cell lines leads to increased extracellular vesicles biogenesis and PD-L1 cargo in a PI3K-dependent manner. Sanchez JC, Pierpont TM, Argueta-Zamora D, Wilson K, August A, Cerione RA. bioRxiv [Preprint]. 2024 Mar 2:2023.07.26.550575. doi: 10.1101/2023.07.26.550575. PubMed |
| The loss of OPA1 accelerates intervertebral disc degeneration and osteoarthritis in aged mice. Risbud M, Madhu V, Hernandez-Meadows M, Coleman A, Sao K, Inguito K, Haslam O, Boneski P, Sesaki H, Collins J. Res Sq [Preprint]. 2024 Feb 20:rs.3.rs-3950044. doi: 10.21203/rs.3.rs-3950044/v1. PubMed |
| Non-linear transcriptional responses to gradual modulation of transcription factor dosage. Domingo J, Minaeva M, Morris JA, Ziosi M, Sanjana NE, Lappalainen T. bioRxiv [Preprint]. 2024 Mar 3:2024.03.01.582837. doi: 10.1101/2024.03.01.582837. PubMed |
| Novel Estrogen Receptor Dimerization BRET-Based Biosensors for Screening Estrogenic Endocrine-Disrupting Chemicals. Choi G, Kang H, Suh JS, Lee H, Han K, Yoo G, Jo H, Shin YM, Kim TJ, Youn B. Biomater Res. 2024 Mar 7;28:0010. doi: 10.34133/bmr.0010. eCollection 2024. PubMed |
| Paxillin phase separation promotes focal adhesion assembly and integrin signaling. Liang P, Wu Y, Zheng S, Zhang J, Yang S, Wang J, Ma S, Zhang M, Gu Z, Liu Q, Jiang W, Xing Q, Wang B. J Cell Biol. 2024 Apr 1;223(4):e202209027. doi: 10.1083/jcb.202209027. Epub 2024 Mar 11. PubMed |
| USP22 regulates APL differentiation via PML-RARalpha stabilization and IFN repression. Kowald L, Roedig J, Karlowitz R, Wagner K, Smith S, Juretschke T, Beli P, Muller S, van Wijk SJL. Cell Death Discov. 2024 Mar 11;10(1):128. doi: 10.1038/s41420-024-01894-8. PubMed |
| Mitochondrial metabolism sustains CD8(+) T cell migration for an efficient infiltration into solid tumors. Simula L, Fumagalli M, Vimeux L, Rajnpreht I, Icard P, Birsen G, An D, Pendino F, Rouault A, Bercovici N, Damotte D, Lupo-Mansuet A, Alifano M, Alves-Guerra MC, Donnadieu E. Nat Commun. 2024 Mar 11;15(1):2203. doi: 10.1038/s41467-024-46377-7. PubMed |
| The role of Smarcad1 in retroviral repression in mouse embryonic stem cells. Bren I, Tal A, Strauss C, Schlesinger S. Mob DNA. 2024 Mar 11;15(1):4. doi: 10.1186/s13100-024-00314-z. PubMed |
| Cardiomyocyte-fibroblast interaction regulates ferroptosis and fibrosis after myocardial injury. Mohr ME, Li S, Trouten AM, Stairley RA, Roddy PL, Liu C, Zhang M, Sucov HM, Tao G. iScience. 2024 Feb 15;27(3):109219. doi: 10.1016/j.isci.2024.109219. eCollection 2024 Mar 15. PubMed |
| The recruitment of TRiC chaperonin in rotavirus viroplasms correlates with virus replication. Vetter J, Papa G, Tobler K, Rodriguez JM, Kley M, Myers M, Wiesendanger M, Schraner EM, Luque D, Burrone OR, Fraefel C, Eichwald C. mBio. 2024 Apr 10;15(4):e0049924. doi: 10.1128/mbio.00499-24. Epub 2024 Mar 12. PubMed |
| Protocol for the isolation of tumor cell-derived extracellular vesicles followed by in vivo metastasis assessment in a murine ovarian cancer model. Mittal S, Kumar S, Gupta P, Singh M, Chaluvally-Raghavan P, Pradeep S. STAR Protoc. 2024 Jun 21;5(2):102943. doi: 10.1016/j.xpro.2024.102943. Epub 2024 Mar 11. PubMed |
| TRIM33 Is a Co-Regulator of Estrogen Receptor Alpha. Romo BA, Karakyriakou B, Cressey L, Brauer BL, Yang H, Warren A, Johnson AL, Kettenbach AN, Miller TW. Cancers (Basel). 2024 Feb 20;16(5):845. doi: 10.3390/cancers16050845. PubMed |
| Deletion of Sarcolemmal Membrane-Associated Protein Isoform 3 (SLMAP3) in Cardiac Progenitors Delays Embryonic Growth of Myocardium without Affecting Hippo Pathway. Rehmani T, Dias AP, Kamal M, Salih M, Tuana BS. Int J Mol Sci. 2024 Mar 1;25(5):2888. doi: 10.3390/ijms25052888. PubMed |
| The Impact of SLC2A8 RNA Interference on Glucose Uptake and the Transcriptome of Human Trophoblast Cells. Lipka A, Paukszto L, Kennedy VC, Tanner AR, Majewska M, Anthony RV. Cells. 2024 Feb 24;13(5):391. doi: 10.3390/cells13050391. PubMed |
Genetically Encoded XTEN-based Hydrogels with Tunable Viscoelasticity and Biodegradability for Injectable Cell Therapies.
Bennett JI, Boit MO, Gregorio NE, Zhang F, Kibler RD, Hoye JW, Prado O, Rapp PB, Murry CE, Stevens KR, DeForest CA.
Adv Sci (Weinh). 2024 Mar 13:e2301708. doi: 10.1002/advs.202301708.
PubMed
Associated Plasmids |
| DPM1 modulates desmosomal adhesion and epidermal differentiation through SERPINB5. Rathod M, Franz H, Beyersdorfer V, Wanuske MT, Leal-Fischer K, Hanns P, Studle C, Zimmermann A, Buczak K, Schinner C, Spindler V. J Cell Biol. 2024 Apr 1;223(4):e202305006. doi: 10.1083/jcb.202305006. Epub 2024 Mar 13. PubMed |
| Bile acids modified by the intestinal microbiota promote colorectal cancer growth by suppressing CD8(+) T cell effector functions. Cong J, Liu P, Han Z, Ying W, Li C, Yang Y, Wang S, Yang J, Cao F, Shen J, Zeng Y, Bai Y, Zhou C, Ye L, Zhou R, Guo C, Cang C, Kasper DL, Song X, Dai L, Sun L, Pan W, Zhu S. Immunity. 2024 Apr 9;57(4):876-889.e11. doi: 10.1016/j.immuni.2024.02.014. Epub 2024 Mar 12. PubMed |
| RNF166 promotes colorectal cancer progression by recognizing and destabilizing poly-ADP-ribosylated angiomotins. Li Y, Zhang X, Liu N, Liu R, Zhang W, Chen L, Chen Y. Cell Death Dis. 2024 Mar 13;15(3):211. doi: 10.1038/s41419-024-06595-9. PubMed |
| PRMT5 is an actionable therapeutic target in CDK4/6 inhibitor-resistant ER+/RB-deficient breast cancer. Lin CC, Chang TC, Wang Y, Guo L, Gao Y, Bikorimana E, Lemoff A, Fang YV, Zhang H, Zhang Y, Ye D, Soria-Bretones I, Servetto A, Lee KM, Luo X, Otto JJ, Akamatsu H, Napolitano F, Mani R, Cescon DW, Xu L, Xie Y, Mendell JT, Hanker AB, Arteaga CL. Nat Commun. 2024 Mar 13;15(1):2287. doi: 10.1038/s41467-024-46495-2. PubMed |
| PRODH safeguards human naive pluripotency by limiting mitochondrial oxidative phosphorylation and reactive oxygen species production. Chen C, Liu Q, Chen W, Gong Z, Kang B, Sui M, Huang L, Wang YJ. EMBO Rep. 2024 Apr;25(4):2015-2044. doi: 10.1038/s44319-024-00110-z. Epub 2024 Mar 13. PubMed |
| Inhibition of BRD4 Attenuates ER Stress-induced Renal Ischemic-Reperfusion Injury. Diaz-Bulnes P, Rodriguez RM, Banon-Maneus E, Saiz ML, Bernet CR, Corte-Iglesias V, Ramirez-Bajo MJ, Lazo-Rodriguez M, Tamargo-Gomez I, Rodrigues-Diez RR, Sanz AB, Diaz-Corte C, Ruiz-Ortega M, Diekmann F, Aransay AM, Lopez-Larrea C, Suarez-Alvarez B. Int J Biol Sci. 2024 Feb 11;20(5):1547-1562. doi: 10.7150/ijbs.83040. eCollection 2024. PubMed |
| Mitophagy defect mediates the aging-associated hallmarks in Hutchinson-Gilford progeria syndrome. Sun Y, Xu L, Li Y, Jia S, Wang G, Cen X, Xu Y, Cao Z, Wang J, Shen N, Hu L, Zhang J, Mao J, Xia H, Liu Z, Fu X. Aging Cell. 2024 Jun;23(6):e14143. doi: 10.1111/acel.14143. Epub 2024 Mar 14. PubMed |
Continuous evolution of compact protein degradation tags regulated by selective molecular glues.
Mercer JAM, DeCarlo SJ, Roy Burman SS, Sreekanth V, Nelson AT, Hunkeler M, Chen PJ, Donovan KA, Kokkonda P, Tiwari PK, Shoba VM, Deb A, Choudhary A, Fischer ES, Liu DR.
Science. 2024 Mar 15;383(6688):eadk4422. doi: 10.1126/science.adk4422. Epub 2024 Mar 15.
PubMed
Associated Plasmids |
| The sirtuin-associated human senescence program converges on the activation of placenta-specific gene PAPPA. Bi S, Jiang X, Ji Q, Wang Z, Ren J, Wang S, Yu Y, Wang R, Liu Z, Liu J, Hu J, Sun G, Wu Z, Diao Z, Li J, Sun L, Izpisua Belmonte JC, Zhang W, Liu GH, Qu J. Dev Cell. 2024 Apr 22;59(8):991-1009.e12. doi: 10.1016/j.devcel.2024.02.008. Epub 2024 Mar 13. PubMed |
| The cholesterol biosynthesis enzyme FAXDC2 couples Wnt/beta-catenin to RTK/MAPK signaling. Madan B, Wadia SR, Patnaik S, Harmston N, Tan E, Tan IBH, Nes WD, Petretto E, Virshup DM. J Clin Invest. 2024 Jan 23;134(6):e171222. doi: 10.1172/JCI171222. PubMed |
| Vasorin Exocytosed from Glioma Cells Facilitates Angiogenesis via VEGFR2/AKT Signaling Pathway. Zhong Y, Kang H, Ma Z, Li J, Qin Z, Zhang Z, Li P, Zhong Y, Wang L. Mol Cancer Res. 2024 Jul 2;22(7):668-681. doi: 10.1158/1541-7786.MCR-23-0469. PubMed |
| De novo steroidogenesis in tumor cells drives bone metastasis and osteoclastogenesis. Sandor LF, Huh JB, Benko P, Hiraga T, Poliska S, Dobo-Nagy C, Simpson JP, Homer NZM, Mahata B, Gyori DS. Cell Rep. 2024 Mar 26;43(3):113936. doi: 10.1016/j.celrep.2024.113936. Epub 2024 Mar 13. PubMed |
| ATF3-CBS signaling axis coordinates ferroptosis and tumorigenesis in colorectal cancer. Liu J, Lu X, Zeng S, Fu R, Wang X, Luo L, Huang T, Deng X, Zheng H, Ma S, Ning D, Zong L, Lin SH, Zhang Y. Redox Biol. 2024 May;71:103118. doi: 10.1016/j.redox.2024.103118. Epub 2024 Mar 8. PubMed |
| PLEKHM2 deficiency induces impaired mitochondrial clearance and elevated ROS levels in human iPSC-derived cardiomyocytes. Zhang J, Peng Y, Fu W, Wang R, Cao J, Li S, Tian X, Li Z, Hua C, Zhai Y, Liu Y, Liu M, Sun J, Li X, Zhao X, Dong J. Cell Death Discov. 2024 Mar 15;10(1):142. doi: 10.1038/s41420-024-01907-6. PubMed |
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| Long non-coding RNA RAD51-AS1 promotes the tumorigenesis of ovarian cancer by elevating EIF5A2 expression. Zhao L, Huang J, Liu W, Su X, Zhao B, Wang X, He X. J Cancer Res Clin Oncol. 2024 Apr 7;150(4):179. doi: 10.1007/s00432-024-05671-z. PubMed |
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| Human long noncoding RNA, VILMIR, is induced by major respiratory viral infections and modulates the host interferon response. John K, Huntress I, Smith E, Chou H, Tollison TS, Covarrubias S, Crisci E, Carpenter S, Peng X. bioRxiv [Preprint]. 2024 Mar 29:2024.03.25.586578. doi: 10.1101/2024.03.25.586578. PubMed |
| Mutational scanning of CRX classifies clinical variants and reveals biochemical properties of the transcriptional effector domain. Shepherdson JL, Granas DM, Li J, Shariff Z, Plassmeyer SP, Holehouse AS, White MA, Cohen BA. bioRxiv [Preprint]. 2024 Mar 27:2024.03.21.585809. doi: 10.1101/2024.03.21.585809. PubMed |
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| Identifying human pre-mRNA cleavage and polyadenylation factors by genome-wide CRISPR screens using a dual fluorescence readthrough reporter. Ni Z, Ahmed N, Nabeel-Shah S, Guo X, Pu S, Song J, Marcon E, Burke GL, Tong AHY, Chan K, Ha KCH, Blencowe BJ, Moffat J, Greenblatt JF. Nucleic Acids Res. 2024 May 8;52(8):4483-4501. doi: 10.1093/nar/gkae240. PubMed |
| GHITM regulates malignant phenotype and sensitivity to PD-1 blockade of renal cancer cells via Notch signalling. Huang S, Liu J, Hu J, Hou Y, Hu M, Zhang B, Luo H, Fu S, Chen Y, Liu X, Chen Z, Wang L. J Cell Mol Med. 2024 Apr;28(8):e18290. doi: 10.1111/jcmm.18290. PubMed |
| SLC38A2 promotes cell proliferation and invasion by promoting glutamine metabolism in adenomyosis. Wu K, Gong W, Hu JC, Duan YC, Ke HH, Chen L. Exp Ther Med. 2024 Mar 21;27(5):218. doi: 10.3892/etm.2024.12506. eCollection 2024 May. PubMed |
| ISG12a promotes immunotherapy of HBV-associated hepatocellular carcinoma through blocking TRIM21/AKT/beta-catenin/PD-L1 axis. Deng R, Tian R, Li X, Xu Y, Li Y, Wang X, Li H, Wang L, Xu B, Yang D, Tang S, Xue B, Zuo C, Zhu H. iScience. 2024 Mar 19;27(4):109533. doi: 10.1016/j.isci.2024.109533. eCollection 2024 Apr 19. PubMed |
| MILIP Binding to tRNAs Promotes Protein Synthesis to Drive Triple-Negative Breast Cancer. Zheng SM, Feng YC, Zhu Q, Li RQ, Yan QQ, Teng L, Yue YM, Han MM, Ye K, Zhang SN, Qi TF, Tang CX, Zhao XH, Zhang YY, Xu L, Xu R, Xing J, Baker M, Liu T, Thorne RF, Jin L, Preiss T, Zhang XD, Cang S, Gao JN. Cancer Res. 2024 May 2;84(9):1460-1474. doi: 10.1158/0008-5472.CAN-23-3046. PubMed |
| BLM helicase unwinds lagging strand substrates to assemble the ALT telomere damage response. Jiang H, Zhang T, Kaur H, Shi T, Krishnan A, Kwon Y, Sung P, Greenberg RA. Mol Cell. 2024 May 2;84(9):1684-1698.e9. doi: 10.1016/j.molcel.2024.03.011. Epub 2024 Apr 8. PubMed |
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| The clinical utility and diagnostic implementation of human subject cell transdifferentiation followed by RNA sequencing. Li S, Zhao S, Sinson JC, Bajic A, Rosenfeld JA, Neeley MB, Pena M, Worley KC, Burrage LC, Weisz-Hubshman M, Ketkar S, Craigen WJ, Clark GD, Lalani S, Bacino CA, Machol K, Chao HT, Potocki L, Emrick L, Sheppard J, Nguyen MTT, Khoramnia A, Hernandez PP, Nagamani SC, Liu Z, Eng CM, Lee B, Liu P. Am J Hum Genet. 2024 May 2;111(5):841-862. doi: 10.1016/j.ajhg.2024.03.007. Epub 2024 Apr 8. PubMed |
| FcRn regulates antigen presentation in dendritic cells downstream of DEC205-targeted vaccines. Macri C, Paxman M, Jenika D, Lin XP, Elahi Z, Gleeson PA, Caminschi I, Lahoud MH, Villadangos JA, Mintern JD. NPJ Vaccines. 2024 Apr 9;9(1):76. doi: 10.1038/s41541-024-00854-8. PubMed |
| Abemaciclib and Vacuolin-1 decrease aggregate-prone TDP-43 accumulation by accelerating autophagic flux. Tanaka Y, Kozuma L, Hino H, Takeya K, Eto M. Biochem Biophys Rep. 2024 Apr 1;38:101705. doi: 10.1016/j.bbrep.2024.101705. eCollection 2024 Jul. PubMed |
Messenger RNA transport on lysosomal vesicles maintains axonal mitochondrial homeostasis and prevents axonal degeneration.
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| CBX7C⋅PHC2 interaction facilitates PRC1 assembly and modulates its phase separation properties. Guan S, Tang J, Ma X, Miao R, Cheng B. iScience. 2024 Mar 21;27(4):109548. doi: 10.1016/j.isci.2024.109548. eCollection 2024 Apr 19. PubMed |
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| Unveiling IL6R and MYC as Targeting Biomarkers in Imatinib-Resistant Chronic Myeloid Leukemia through Advanced Non-Invasive Apoptosis Detection Sensor Version 2 Detection. Lee CH, Hsu KW, Hsieh YY, Li WT, Long Y, Lin CY, Chen SH. Cells. 2024 Apr 2;13(7):616. doi: 10.3390/cells13070616. PubMed |
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| Augmented ERO1alpha upon mTORC1 activation induces ferroptosis resistance and tumor progression via upregulation of SLC7A11. Wang Z, Zong H, Liu W, Lin W, Sun A, Ding Z, Chen X, Wan X, Liu Y, Hu Z, Zhang H, Li H, Liu Y, Li D, Zhang S, Zha X. J Exp Clin Cancer Res. 2024 Apr 13;43(1):112. doi: 10.1186/s13046-024-03039-2. PubMed |
| Synergy between BRD9- and IKZF3-Targeting as a Therapeutic Strategy for Multiple Myeloma. Chowdhury B, Garg S, Ni W, Sattler M, Sanchez D, Meng C, Akatsu T, Stone R, Forrester W, Harrington E, Buhrlage SJ, Griffin JD, Weisberg E. Cancers (Basel). 2024 Mar 28;16(7):1319. doi: 10.3390/cancers16071319. PubMed |
| FL118 Is a Potent Therapeutic Agent against Chronic Myeloid Leukemia Resistant to BCR-ABL Inhibitors through Targeting RNA Helicase DDX5. Takeda K, Ohta S, Nagao M, Kobayashi E, Tago K, Funakoshi-Tago M. Int J Mol Sci. 2024 Mar 26;25(7):3693. doi: 10.3390/ijms25073693. PubMed |
| Transmembrane Protein TMEM230, Regulator of Glial Cell Vascular Mimicry and Endothelial Cell Angiogenesis in High-Grade Heterogeneous Infiltrating Gliomas and Glioblastoma. Cocola C, Abeni E, Martino V, Piscitelli E, Pelucchi P, Mosca E, Chiodi A, Mohamed T, Palizban M, Porta G, Palizban H, Nano G, Acquati F, Bruno A, Greve B, Gerovska D, Magnaghi V, Mazzaccaro D, Bertalot G, Kehler J, Balbino C, Arauzo-Bravo MJ, Gotte M, Zucchi I, Reinbold RA. Int J Mol Sci. 2024 Apr 3;25(7):3967. doi: 10.3390/ijms25073967. PubMed |
| Squalene-epoxidase-catalyzed 24(S),25-epoxycholesterol synthesis promotes trained-immunity-mediated antitumor activity. Liu Y, Wang Z, Jin H, Cui L, Huo B, Xie C, Li J, Ding H, Zhang H, Xiong W, Li M, Zhang H, Guo H, Li C, Wang T, Wang X, He W, Wang Z, Bei JX, Huang P, Liu J, Xia X. Cell Rep. 2024 Apr 23;43(4):114094. doi: 10.1016/j.celrep.2024.114094. Epub 2024 Apr 11. PubMed |
| SHIP inhibition mediates select TREM2-induced microglial functions. Ramakrishnan GS, Berry WL, Pacherille A, Kerr WG, Chisholm JD, Pedicone C, Humphrey MB. Mol Immunol. 2024 Jun;170:35-45. doi: 10.1016/j.molimm.2024.04.002. Epub 2024 Apr 12. PubMed |
| Targeting high circDNA2v levels in colorectal cancer induces cellular senescence and elicits an anti-tumor secretome. Wu S, Dai X, Xia Y, Zhao Q, Zhao H, Shi Z, Yin X, Liu X, Zhang A, Yao Z, Zhang H, Li Q, Thorne RF, Zhang S, Sheng W, Hu W, Gu H. Cell Rep. 2024 Apr 23;43(4):114111. doi: 10.1016/j.celrep.2024.114111. Epub 2024 Apr 12. PubMed |
| A disease-associated PPP2R3C-MAP3K1 phospho-regulatory module controls centrosome function. Ganga AK, Sweeney LK, Ramos AR, Bishop CS, Hamel V, Guichard P, Breslow DK. bioRxiv [Preprint]. 2024 Apr 3:2024.04.02.587836. doi: 10.1101/2024.04.02.587836. PubMed |
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| Abscisic acid signaling through LANCL2 and PPARgamma induces activation of p38MAPK resulting in dormancy of prostate cancer metastatic cells. Parajuli KR, Jung Y, Taichman RS. Oncol Rep. 2024 Mar;51(3):39. doi: 10.3892/or.2024.8698. Epub 2024 Jan 12. PubMed |
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| Differential nanoscale organization of excitatory synapses onto excitatory vs. inhibitory neurons. Dharmasri PA, Levy AD, Blanpied TA. Proc Natl Acad Sci U S A. 2024 Apr 23;121(17):e2315379121. doi: 10.1073/pnas.2315379121. Epub 2024 Apr 16. PubMed |
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| circRNA-PTPN4 mediated regulation of FOXO3 and ZO-1 expression: implications for blood-brain barrier integrity and cognitive function in uremic encephalopathy. Liu Y, Qin Y, Zhang Y. Cell Biol Toxicol. 2024 Apr 17;40(1):22. doi: 10.1007/s10565-024-09865-6. PubMed |
| A p85 isoform switch enhances PI3K activation on endosomes by a MAP4- and PI3P-dependent mechanism. Thapa N, Chen M, Cryns VL, Anderson R. Cell Rep. 2024 May 28;43(5):114119. doi: 10.1016/j.celrep.2024.114119. Epub 2024 Apr 16. PubMed |
| TAK1 inhibition leads to RIPK1-dependent apoptosis in immune-activated cancers. Damhofer H, Tatar T, Southgate B, Scarneo S, Agger K, Shlyueva D, Uhrbom L, Morrison GM, Hughes PF, Haystead T, Pollard SM, Helin K. Cell Death Dis. 2024 Apr 17;15(4):273. doi: 10.1038/s41419-024-06654-1. PubMed |
| Protocol for efficient CRISPR-Cas9-mediated fluorescent tag knockin in hard-to-transfect erythroid cell lines. Deleuze V, Soler E, Andrieu-Soler C. STAR Protoc. 2024 Jun 21;5(2):103016. doi: 10.1016/j.xpro.2024.103016. Epub 2024 Apr 17. PubMed |
| RBM22 regulates RNA polymerase II 5' pausing, elongation rate, and termination by coordinating 7SK-P-TEFb complex and SPT5. Du X, Qin W, Yang C, Dai L, San M, Xia Y, Zhou S, Wang M, Wu S, Zhang S, Zhou H, Li F, He F, Tang J, Chen JY, Zhou Y, Xiao R. Genome Biol. 2024 Apr 19;25(1):102. doi: 10.1186/s13059-024-03242-6. PubMed |
| Stepwise Stiffening/Softening of and Cell Recovery from Reversibly Formulated Hydrogel Double Networks. Kopyeva I, Goldner EC, Hoye JW, Yang S, Regier MC, Vera KR, Bretherton RC, DeForest CA. bioRxiv [Preprint]. 2024 Apr 8:2024.04.04.588191. doi: 10.1101/2024.04.04.588191. PubMed |
| The neuroendocrine transition in prostate cancer is dynamic and dependent on ASCL1. Romero R, Chu T, Gonzalez-Robles TJ, Smith P, Xie Y, Kaur H, Yoder S, Zhao H, Mao C, Kang W, Pulina MV, Lawrence KE, Gopalan A, Zaidi S, Yoo K, Choi J, Fan N, Gerstner O, Karthaus WR, DeStanchina E, Ruggles KV, Westcott PMK, Chaligne R, Pe'er D, Sawyers CL. bioRxiv [Preprint]. 2024 Apr 11:2024.04.09.588557. doi: 10.1101/2024.04.09.588557. PubMed |
| CK2alpha-mediated phosphorylation of GRP94 facilitates the metastatic cascade in triple-negative breast cancer. Kim HY, Kim YM, Hong S. Cell Death Discov. 2024 Apr 22;10(1):185. doi: 10.1038/s41420-024-01956-x. PubMed |
| NKX2-5 regulates vessel remodeling in scleroderma-associated pulmonary arterial hypertension. Papaioannou I, Dritsoula A, Kang P, Baliga RS, Trinder SL, Cook E, Shiwen X, Hobbs AJ, Denton CP, Abraham DJ, Ponticos M. JCI Insight. 2024 Apr 23;9(10):e164191. doi: 10.1172/jci.insight.164191. PubMed |
| Sedentary behavior in mice induces metabolic inflexibility by suppressing skeletal muscle pyruvate metabolism. Siripoksup P, Cao G, Cluntun AA, Maschek JA, Pearce Q, Brothwell MJ, Jeong MY, Eshima H, Ferrara PJ, Opurum PC, Mahmassani ZS, Peterlin AD, Watanabe S, Walsh MA, Taylor EB, Cox JE, Drummond MJ, Rutter J, Funai K. J Clin Invest. 2024 Apr 23;134(11):e167371. doi: 10.1172/JCI167371. PubMed |
| Targeting NRAS via miR-1304-5p or farnesyltransferase inhibition confers sensitivity to ALK inhibitors in ALK-mutant neuroblastoma. Pucci P, Lee LC, Han M, Matthews JD, Jahangiri L, Schlederer M, Manners E, Sorby-Adams A, Kaggie J, Trigg RM, Steel C, Hare L, James ER, Prokoph N, Ducray SP, Merkel O, Rifatbegovic F, Luo J, Taschner-Mandl S, Kenner L, Burke GAA, Turner SD. Nat Commun. 2024 Apr 23;15(1):3422. doi: 10.1038/s41467-024-47771-x. PubMed |
| Temporal coordination of the transcription factor response to H(2)O(2) stress. Jose E, March-Steinman W, Wilson BA, Shanks L, Parkinson C, Alvarado-Cruz I, Sweasy JB, Paek AL. Nat Commun. 2024 Apr 23;15(1):3440. doi: 10.1038/s41467-024-47837-w. PubMed |
| BAG3 regulates cilia homeostasis of glioblastoma via its WW domain. Roth C, Paulini L, Hoffmann ME, Mosler T, Dikic I, Brunschweiger A, Korschgen H, Behl C, Linder B, Kogel D. Biofactors. 2024 Apr 24. doi: 10.1002/biof.2060. PubMed |
| ASPSCR1::TFE3 Drives Alveolar Soft Part Sarcoma by Inducing Targetable Transcriptional Programs. Sicinska E, Kola VSR, Kerfoot JA, Taddei ML, Al-Ibraheemi A, Hsieh YH, Church AJ, Landesman-Bollag E, Landesman Y, Hemming ML. Cancer Res. 2024 Jul 15;84(14):2247-2264. doi: 10.1158/0008-5472.CAN-23-2115. PubMed |
| IGSF8 is an innate immune checkpoint and cancer immunotherapy target. Li Y, Wu X, Sheng C, Liu H, Liu H, Tang Y, Liu C, Ding Q, Xie B, Xiao X, Zheng R, Yu Q, Guo Z, Ma J, Wang J, Gao J, Tian M, Wang W, Zhou J, Jiang L, Gu M, Shi S, Paull M, Yang G, Yang W, Landau S, Bao X, Hu X, Liu XS, Xiao T. Cell. 2024 May 23;187(11):2703-2716.e23. doi: 10.1016/j.cell.2024.03.039. Epub 2024 Apr 23. PubMed |
Synthetic protein circuits for programmable control of mammalian cell death.
Xia S, Lu AC, Tobin V, Luo K, Moeller L, Shon DJ, Du R, Linton JM, Sui M, Horns F, Elowitz MB.
Cell. 2024 Apr 16:S0092-8674(24)00347-7. doi: 10.1016/j.cell.2024.03.031.
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| Genome-wide CRISPR screens identify the YAP/TEAD axis as a driver of persister cells in EGFR mutant lung cancer. Pfeifer M, Brammeld JS, Price S, Pilling J, Bhavsar D, Farcas A, Bateson J, Sundarrajan A, Miragaia RJ, Guan N, Arnold S, Tariq L, Grondine M, Talbot S, Guerriero ML, O'Neill DJ, Young J, Company C, Dunn S, Thorpe H, Martin MJ, Maratea K, Barrell D, Ahdesmaki M, Mettetal JT, Brownell J, McDermott U. Commun Biol. 2024 Apr 24;7(1):497. doi: 10.1038/s42003-024-06190-w. PubMed |
| Ribosomal S6 kinase 2-forkhead box protein O4 signaling pathway plays an essential role in melanogenesis. Jeung D, Lee GE, Chen W, Byun J, Nam SB, Park YM, Lee HS, Kang HC, Lee JY, Kim KD, Hong YS, Lee CJ, Kim DJ, Cho YY. Sci Rep. 2024 Apr 24;14(1):9440. doi: 10.1038/s41598-024-60165-9. PubMed |
| Spatiotemporal proteomic profiling of cellular responses to NLRP3 agonists. Hollingsworth LR, Veeraraghavan P, Paulo JA, Harper JW, Rauch I. bioRxiv [Preprint]. 2024 Apr 20:2024.04.19.590338. doi: 10.1101/2024.04.19.590338. PubMed |
| DOT1-like histone lysine methyltransferase is critical for adult vessel maintenance and functions. Lee H, Han DW, La H, Park C, Kang K, Kwon O, Uhm SJ, Song H, Do JT, Choi Y, Hong K. Anim Biosci. 2024 Sep;37(9):1635-1643. doi: 10.5713/ab.23.0402. Epub 2024 Apr 24. PubMed |
| CRISPR-Cas9 screening identifies INTS3 as an anti-apoptotic RNA-binding protein and therapeutic target for colorectal cancer. Wang Z, Zhang C, Guo J, Yang Y, Li P, Wang Z, Liu S, Zhang L, Zeng X, Zhai J, Wang X, Zhao Q, Chen Z, Zhu P, He Q. iScience. 2024 Apr 6;27(5):109676. doi: 10.1016/j.isci.2024.109676. eCollection 2024 May 17. PubMed |
| Establishment and Characterization of SV40 T-Antigen Immortalized Porcine Muscle Satellite Cell. Ni M, He J, Li T, Zhao G, Ji Z, Ren F, Leng J, Wu M, Huang R, Li P, Hou L. Cells. 2024 Apr 18;13(8):703. doi: 10.3390/cells13080703. PubMed |
| Functional sensory circuits built from neurons of two species. Throesch BT, Bin Imtiaz MK, Munoz-Castaneda R, Sakurai M, Hartzell AL, James KN, Rodriguez AR, Martin G, Lippi G, Kupriyanov S, Wu Z, Osten P, Izpisua Belmonte JC, Wu J, Baldwin KK. Cell. 2024 Apr 25;187(9):2143-2157.e15. doi: 10.1016/j.cell.2024.03.042. PubMed |
| Positive selection CRISPR screens reveal a druggable pocket in an oligosaccharyltransferase required for inflammatory signaling to NF-kappaB. Lampson BL, Ramiotarez AS, Baro M, He L, Hegde M, Koduri V, Pfaff JL, Hanna RE, Kowal J, Shirole NH, He Y, Doench JG, Contessa JN, Locher KP, Kaelin WG Jr. Cell. 2024 Apr 25;187(9):2209-2223.e16. doi: 10.1016/j.cell.2024.03.022. PubMed |
| Exploiting a subtype-specific mitochondrial vulnerability for successful treatment of colorectal peritoneal metastases. Bootsma S, Dings MPG, Kesselaar J, Helderman RFCPA, van Megesen K, Constantinides A, Moreno LF, Stelloo E, Scutigliani EM, Bokan B, Torang A, van Hooff SR, Zwijnenburg DA, Wouters VM, van de Vlasakker VCJ, Galanos LJK, Nijman LE, Logiantara A, Veenstra VL, Schlingemann S, van Piggelen S, van der Wel N, Krawczyk PM, Platteeuw JJ, Tuynman JB, de Hingh IH, Klomp JPG, Oubrie A, Snaebjornsson P, Medema JP, Oei AL, Kranenburg O, Elbers CC, Lenos KJ, Vermeulen L, Bijlsma MF. Cell Rep Med. 2024 May 21;5(5):101523. doi: 10.1016/j.xcrm.2024.101523. Epub 2024 Apr 25. PubMed |
| Collagen IV assembly is influenced by fluid flow in kidney cell-derived matrices. Tian P, Koudis NM, Morais MRPT, Pickard A, Fresquet M, Adamson A, Derby B, Lennon R. Cells Dev. 2024 Apr 24:203923. doi: 10.1016/j.cdev.2024.203923. PubMed |
| IL-6 promotes tumor growth through immune evasion but is dispensable for cachexia. Kwon YY, Hui S. EMBO Rep. 2024 Jun;25(6):2592-2609. doi: 10.1038/s44319-024-00144-3. Epub 2024 Apr 26. PubMed |
| SCF(FBXW11) Complex Targets Interleukin-17 Receptor A for Ubiquitin-Proteasome-Mediated Degradation. Jin B, Moududee SA, Ge D, Zhou P, Wang AR, Liu YZ, You Z. Biomedicines. 2024 Mar 28;12(4):755. doi: 10.3390/biomedicines12040755. PubMed |
| Chromatin Profiles Are Prognostic of Clinical Response to Bortezomib-Containing Chemotherapy in Pediatric Acute Myeloid Leukemia: Results from the COG AAML1031 Trial. van Dijk AD, Hoff FW, Qiu Y, Hubner SE, Go RL, Ruvolo VR, Leonti AR, Gerbing RB, Gamis AS, Aplenc R, Kolb EA, Alonzo TA, Meshinchi S, de Bont ESJM, Horton TM, Kornblau SM. Cancers (Basel). 2024 Apr 9;16(8):1448. doi: 10.3390/cancers16081448. PubMed |
| Missing WD40 Repeats in ATG16L1 Delays Canonical Autophagy and Inhibits Noncanonical Autophagy. Tang J, Fang D, Zhong J, Li M. Int J Mol Sci. 2024 Apr 19;25(8):4493. doi: 10.3390/ijms25084493. PubMed |
| MHC class I-dressing is mediated via phosphatidylserine recognition and is enhanced by polyI:C. Hori A, Toyoura S, Fujiwara M, Taniguchi R, Kano Y, Yamano T, Hanayama R, Nakayama M. iScience. 2024 Apr 10;27(5):109704. doi: 10.1016/j.isci.2024.109704. eCollection 2024 May 17. PubMed |
| SARS-CoV-2 NSP5 antagonizes MHC II expression by subverting histone deacetylase 2. Taefehshokr N, Lac A, Vrieze AM, Dickson BH, Guo PN, Jung C, Blythe EN, Fink C, Aktar A, Dikeakos JD, Dekaban GA, Heit B. J Cell Sci. 2024 May 15;137(10):jcs262172. doi: 10.1242/jcs.262172. Epub 2024 May 22. PubMed |
| Ribosome subunit attrition and activation of the p53-MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition. Howard GC, Wang J, Rose KL, Jones C, Patel P, Tsui T, Florian AC, Vlach L, Lorey SL, Grieb BC, Smith BN, Slota MJ, Reynolds EM, Goswami S, Savona MR, Mason FM, Lee T, Fesik S, Liu Q, Tansey WP. Elife. 2024 Apr 29;12:RP90683. doi: 10.7554/eLife.90683. PubMed |
| Glucose hypometabolism prompts RAN translation and exacerbates C9orf72-related ALS/FTD phenotypes. Nelson AT, Cicardi ME, Markandaiah SS, Han JY, Philp NJ, Welebob E, Haeusler AR, Pasinelli P, Manfredi G, Kawamata H, Trotti D. EMBO Rep. 2024 May;25(5):2479-2510. doi: 10.1038/s44319-024-00140-7. Epub 2024 Apr 29. PubMed |
| Germline cis variant determines epigenetic regulation of the anti-cancer drug metabolism gene dihydropyrimidine dehydrogenase (DPYD). Zhang T, Ambrodji A, Huang H, Bouchonville KJ, Etheridge AS, Schmidt RE, Bembenek BM, Temesgen ZB, Wang Z, Innocenti F, Stroka D, Diasio RB, Largiader CR, Offer SM. Elife. 2024 Apr 30;13:RP94075. doi: 10.7554/eLife.94075. PubMed |
| The Mediator Med23 controls a transcriptional switch for muscle stem cell proliferation and differentiation in muscle regeneration. Fang Y, Yuan C, Li C, Lu C, Yu W, Wang G. Cell Rep. 2024 May 28;43(5):114177. doi: 10.1016/j.celrep.2024.114177. Epub 2024 Apr 30. PubMed |
| SETDB1 modulates the TGFbeta response in Duchenne muscular dystrophy myotubes. Granados A, Zamperoni M, Rapone R, Moulin M, Boyarchuk E, Bouyioukos C, Del Maestro L, Joliot V, Negroni E, Mohamed M, Piquet S, Bigot A, Le Grand F, Albini S, Ait-Si-Ali S. Sci Adv. 2024 May 3;10(18):eadj8042. doi: 10.1126/sciadv.adj8042. Epub 2024 May 1. PubMed |
| The epigenetic regulators EP300/CREBBP represent promising therapeutic targets in MLL-rearranged acute myeloid leukemia. Wu W, Jiang Y, Xing D, Zhai Y, Sun H, He X, Luo K, Xu P, Pan F, Dong G, Ren G, Zhao Z. Cell Death Discov. 2024 May 1;10(1):206. doi: 10.1038/s41420-024-01940-5. PubMed |
| An intricate regulatory circuit between FLI1 and GATA1/GATA2/LDB1/ERG dictates erythroid vs. megakaryocytic differentiation. Wang C, Hu M, Yu K, Liu W, Hu A, Kuang Y, Huang L, Gajendran B, Zacksenhaus E, Xiao X, Ben-David Y. Mol Med Rep. 2024 Jun;29(6):107. doi: 10.3892/mmr.2024.13231. Epub 2024 May 2. PubMed |
Epistatic interactions between NMD and TRP53 control progenitor cell maintenance and brain size.
Lin L, Zhao J, Kubota N, Li Z, Lam YL, Nguyen LP, Yang L, Pokharel SP, Blue SM, Yee BA, Chen R, Yeo GW, Chen CW, Chen L, Zheng S.
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PubMed
Associated Plasmids |
| A Method for the Production of Recombinant VSVs with Confirmation of Biological Activity. Moroz VD, Gasanov NB, Egorov AD, Malogolovkin AS, Nagornykh MO, Subcheva EN, Kolosova ES, Fizikova AY, Ivanov RA, Karabelsky AV. Acta Naturae. 2024 Jan-Mar;16(1):59-66. doi: 10.32607/actanaturae.27314. PubMed |
| Expression of nuclear receptor co‑activator 7 protein is associated with poor prognosis of breast cancer. Peng Z, Li Y, Xia S, Dai Q, Yin L, Chen M, Yang W, Shao G, Lin Q. Oncol Lett. 2024 Apr 23;27(6):278. doi: 10.3892/ol.2024.14411. eCollection 2024 Jun. PubMed |
| The anti-leprosy drug clofazimine reduces polyQ toxicity through activation of PPARgamma. Li X, Hernandez I, Koyuncu S, Kis B, Haggblad M, Lidemalm L, Abbas AA, Bendeguz S, Goblos A, Brautigam L, Lucas JJ, Carreras-Puigvert J, Huhn D, Pircs K, Vilchez D, Fernandez-Capetillo O. EBioMedicine. 2024 May;103:105124. doi: 10.1016/j.ebiom.2024.105124. Epub 2024 May 2. PubMed |
| TCF19 promotes cell proliferation and tumor formation in lung cancer by activating the Raf/MEK/ERK signaling pathway. Tian Y, Xin S, Wan Z, Dong H, Liu L, Fan Z, Li T, Peng F, Xiong Y, Han Y. Transl Oncol. 2024 Jul;45:101978. doi: 10.1016/j.tranon.2024.101978. Epub 2024 May 2. PubMed |
| Molecular targets of glucocorticoids that elucidate their therapeutic efficacy in aggressive lymphomas. Choi J, Ceribelli M, Phelan JD, Haupl B, Huang DW, Wright GW, Hsiao T, Morris V, Ciccarese F, Wang B, Corcoran S, Scheich S, Yu X, Xu W, Yang Y, Zhao H, Zhou J, Zhang G, Muppidi J, Inghirami GG, Oellerich T, Wilson WH, Thomas CJ, Staudt LM. Cancer Cell. 2024 May 13;42(5):833-849.e12. doi: 10.1016/j.ccell.2024.04.007. Epub 2024 May 2. PubMed |
| ETV4 is a mechanical transducer linking cell crowding dynamics to lineage specification. Yang S, Golkaram M, Oh S, Oh Y, Cho Y, Yoe J, Ju S, Lalli MA, Park SY, Lee Y, Jang J. Nat Cell Biol. 2024 Jun;26(6):903-916. doi: 10.1038/s41556-024-01415-w. Epub 2024 May 3. PubMed |
| The MYCN oncoprotein is an RNA-binding accessory factor of the nuclear exosome targeting complex. Papadopoulos D, Ha SA, Fleischhauer D, Uhl L, Russell TJ, Mikicic I, Schneider K, Brem A, Valanju OR, Cossa G, Gallant P, Schuelein-Voelk C, Maric HM, Beli P, Buchel G, Vos SM, Eilers M. Mol Cell. 2024 Jun 6;84(11):2070-2086.e20. doi: 10.1016/j.molcel.2024.04.007. Epub 2024 May 3. PubMed |
| Heat shock protein 72 supports extracellular matrix production in metastatic mammary tumors. Lang BJ, Holton KM, Guerrero-Gimenez ME, Okusha Y, Magahis PT, Shi A, Neguse M, Venkatesh S, Nhu AM, Gestwicki JE, Calderwood SK. Cell Stress Chaperones. 2024 Jun;29(3):456-471. doi: 10.1016/j.cstres.2024.04.006. Epub 2024 May 3. PubMed |
| De Novo Multi-Omics Pathway Analysis Designed for Prior Data Independent Inference of Cell Signaling Pathways. Vaparanta K, Merilahti JAM, Ojala VK, Elenius K. Mol Cell Proteomics. 2024 Jul;23(7):100780. doi: 10.1016/j.mcpro.2024.100780. Epub 2024 May 3. PubMed |
| USP20 deubiquitinates and stabilizes the reticulophagy receptor RETREG1/FAM134B to drive reticulophagy. Zhang M, Wang Z, Zhao Q, Yang Q, Bai J, Yang C, Zhang ZR, Liu Y. Autophagy. 2024 Aug;20(8):1780-1797. doi: 10.1080/15548627.2024.2347103. Epub 2024 May 12. PubMed |
| Cell competition promotes metastatic intestinal cancer through a multistage process. Krotenberg Garcia A, Ledesma-Terron M, Lamprou M, Vriend J, van Luyk ME, Suijkerbuijk SJE. iScience. 2024 Apr 11;27(5):109718. doi: 10.1016/j.isci.2024.109718. eCollection 2024 May 17. PubMed |
| The interaction of GRP78 and Zika virus E and NS1 proteins occurs in a chaperone-client manner. Sornjai W, Promma P, Priewkhiew S, Ramphan S, Jaratsittisin J, Jinagool P, Wikan N, Greenwood M, Murphy D, Smith DR. Sci Rep. 2024 May 6;14(1):10407. doi: 10.1038/s41598-024-61195-z. PubMed |
| AKAP8 promotes ovarian cancer progression and antagonizes PARP inhibitor sensitivity through regulating hnRNPUL1 transcription. Mobet Y, Wang H, Wei Q, Liu X, Yang D, Zhao H, Yang Y, Ngono Ngane RA, Souopgui J, Xu J, Liu T, Yi P. iScience. 2024 Apr 16;27(5):109744. doi: 10.1016/j.isci.2024.109744. eCollection 2024 May 17. PubMed |
| Phospholipase PLA2G7 is complementary to GPX4 in mitigating punicic-acid-induced ferroptosis in prostate cancer cells. Vermonden P, Martin M, Glowacka K, Neefs I, Ecker J, Horing M, Liebisch G, Debier C, Feron O, Larondelle Y. iScience. 2024 Apr 18;27(5):109774. doi: 10.1016/j.isci.2024.109774. eCollection 2024 May 17. PubMed |
| New AAV9 engineered variants with enhanced neurotropism and reduced liver off-targeting in mice and marmosets. Giannelli SG, Luoni M, Iannielli A, Middeldorp J, Philippens I, Bido S, Korbelin J, Broccoli V. iScience. 2024 Apr 18;27(5):109777. doi: 10.1016/j.isci.2024.109777. eCollection 2024 May 17. PubMed |
| Functional genomics screens reveal a role for TBC1D24 and SV2B in antibody-dependent enhancement of dengue virus infection. Belmont L, Contreras M, Cartwright-Acar CH, Marceau CD, Agrawal A, Levoir LM, Lubow J, Goo L. bioRxiv [Preprint]. 2024 Apr 27:2024.04.26.591029. doi: 10.1101/2024.04.26.591029. PubMed |
| SFTSV nucleoprotein mediates DNA sensor cGAS degradation to suppress cGAS-dependent antiviral responses. Jiang Z-z, Chu M, Yan L-n, Zhang W-k, Li B, Xu J, Zhao Z-x, Han H-J, Zhou C-m, Yu X-j. Microbiol Spectr. 2024 Jun 4;12(6):e0379623. doi: 10.1128/spectrum.03796-23. Epub 2024 May 7. PubMed |
| Genomic context- and H2AK119 ubiquitination-dependent inheritance of human Polycomb silencing. Shafiq TA, Yu J, Feng W, Zhang Y, Zhou H, Paulo JA, Gygi SP, Moazed D. Sci Adv. 2024 May 10;10(19):eadl4529. doi: 10.1126/sciadv.adl4529. Epub 2024 May 8. PubMed |
| Direct reprogramming of fibroblasts into functional hepatocytes via CRISPRa activation of endogenous Gata4 and Foxa3. Li J, Li R, Bai X, Zhang W, Nie Y, Hu S. Chin Med J (Engl). 2024 Jun 5;137(11):1351-1359. doi: 10.1097/CM9.0000000000003088. Epub 2024 May 9. PubMed |
| Imaging CAR-NK cells targeted to HER2 ovarian cancer with human sodium-iodide symporter-based positron emission tomography. Shalaby N, Xia Y, Kelly JJ, Sanchez-Pupo R, Martinez F, Fox MS, Thiessen JD, Hicks JW, Scholl TJ, Ronald JA. Eur J Nucl Med Mol Imaging. 2024 May 9. doi: 10.1007/s00259-024-06722-w. PubMed |
| Identification of WNK1 as a therapeutic target to suppress IgH/MYC expression in multiple myeloma. Ye T, Mishra AK, Banday S, Li R, Hu K, Coleman MM, Shan Y, Chowdhury SR, Zhou L, Pak ML, Simone TM, Malonia SK, Zhu LJ, Kelliher MA, Green MR. Cell Rep. 2024 May 28;43(5):114211. doi: 10.1016/j.celrep.2024.114211. Epub 2024 May 8. PubMed |
| Resf1 is a compound G4 quadruplex-associated tumor suppressor for triple negative breast cancer. Majocha MR, Jackson DE, Ha NH, Amin R, Pangracova M, Ross CR, Yang HH, Lee MP, Hunter KW. PLoS Genet. 2024 May 9;20(5):e1011236. doi: 10.1371/journal.pgen.1011236. eCollection 2024 May. PubMed |
| An ATP13A1-assisted topogenesis pathway for folding multi-spanning membrane proteins. Ji J, Cui MK, Zou R, Wu MZ, Ge MX, Li J, Zhang ZR. Mol Cell. 2024 May 16;84(10):1917-1931.e15. doi: 10.1016/j.molcel.2024.04.010. Epub 2024 May 8. PubMed |
| Activating innate immune responses repolarizes hPSC-derived CAR macrophages to improve anti-tumor activity. Shen J, Lyu S, Xu Y, Zhang S, Li L, Li J, Mou J, Xie L, Tang K, Wen W, Peng X, Yang Y, Shi Y, Li X, Wang M, Li X, Wang J, Cheng T. Cell Stem Cell. 2024 Jul 5;31(7):1003-1019.e9. doi: 10.1016/j.stem.2024.04.012. Epub 2024 May 8. PubMed |
| The IL-6 signaling pathway contributes critically to the immunomodulatory mechanism of human decidua-derived mesenchymal stromal cells. Na H, Im KI, Kim N, Lee J, Gil S, Min GJ, Cho SG. iScience. 2024 Apr 18;27(5):109783. doi: 10.1016/j.isci.2024.109783. eCollection 2024 May 17. PubMed |
| CD133 Stimulates Cell Proliferation via the Upregulation of Amphiregulin in Melanoma. Simbulan-Rosenthal CM, Islam N, Haribabu Y, Alobaidi R, Shalamzari A, Graham G, Kuo LW, Sykora P, Rosenthal DS. Cells. 2024 May 2;13(9):777. doi: 10.3390/cells13090777. PubMed |
| TFPI from erythroblasts drives heme production in central macrophages promoting erythropoiesis in polycythemia. Ma JK, Su LD, Feng LL, Li JL, Pan L, Danzeng Q, Li Y, Shang T, Zhan XL, Chen SY, Ying S, Hu JR, Chen XQ, Zhang Q, Liang T, Lu XJ. Nat Commun. 2024 May 10;15(1):3976. doi: 10.1038/s41467-024-48328-8. PubMed |
| SP2509, a specific antagonist of LSD1, exhibits antiviral properties against Porcine epidemic diarrhea virus. Zhao X, Zhang Y, Qu S, Tang W, He T, Li P, Zheng X. BMC Vet Res. 2024 May 10;20(1):187. doi: 10.1186/s12917-024-04052-5. PubMed |
| EGCG Disrupts the LIN28B/Let-7 Interaction and Reduces Neuroblastoma Aggressiveness. Cocchi S, Greco V, Sidarovich V, Vigna J, Broso F, Corallo D, Zasso J, Re A, Rosatti EF, Longhi S, Defant A, Ladu F, Sanna V, Adami V, D'Agostino VG, Sturlese M, Sechi M, Aveic S, Mancini I, Sighel D, Quattrone A. Int J Mol Sci. 2024 Apr 27;25(9):4795. doi: 10.3390/ijms25094795. PubMed |
| DDX18 Facilitates the Tumorigenesis of Lung Adenocarcinoma by Promoting Cell Cycle Progression through the Upregulation of CDK4. Feng B, Wang X, Qiu D, Sun H, Deng J, Tan Y, Ji K, Xu S, Zhang S, Tang C. Int J Mol Sci. 2024 May 1;25(9):4953. doi: 10.3390/ijms25094953. PubMed |
| Metabolic regulator ERRgamma governs gastric stem cell differentiation into acid-secreting parietal cells. Adkins-Threats M, Arimura S, Huang YZ, Divenko M, To S, Mao H, Zeng Y, Hwang JY, Burclaff JR, Jain S, Mills JC. Cell Stem Cell. 2024 Jun 6;31(6):886-903.e8. doi: 10.1016/j.stem.2024.04.016. Epub 2024 May 10. PubMed |
| Targeted sequencing for hereditary breast and ovarian cancer in BRCA1/2-negative families reveals complex genetic architecture and phenocopies. Plowman JN, Matoy EJ, Uppala LV, Draves SB, Watson CJ, Sefranek BA, Stacey ML, Anderson SP, Belshan MA, Blue EE, Huff CD, Fu Y, Stessman HAF. HGG Adv. 2024 Jul 18;5(3):100306. doi: 10.1016/j.xhgg.2024.100306. Epub 2024 May 10. PubMed |
| Cyclin-dependent kinase 12 deficiency reprogrammes cellular metabolism to alleviate ferroptosis potential and promote the progression of castration-resistant prostate cancer. Zhang H, Zhou Y, Feng Y, Hou W, Chen Y, Xing Z, Zhang Y, Wei Q, Yin Y, Guo J, Hu H. Clin Transl Med. 2024 May;14(5):e1678. doi: 10.1002/ctm2.1678. PubMed |
| CLEC4D as a Novel Prognostic Marker Boosts the Proliferation and Migration of Gastric Cancer via the NF-kappaB/AKT Signaling Pathway. Yang Y, Zhang M, Cai F, Ma G, Zhang RP, Yin Y, Deng J. Int J Gen Med. 2024 May 6;17:1923-1935. doi: 10.2147/IJGM.S458228. eCollection 2024. PubMed |
| Legionella pneumophila exploits the endo-lysosomal network for phagosome biogenesis by co-opting SUMOylated Rab7. Li C, Fu J, Shao S, Luo ZQ. PLoS Pathog. 2024 May 13;20(5):e1011783. doi: 10.1371/journal.ppat.1011783. eCollection 2024 May. PubMed |
| CRISPR/Cas9 genome editing of CCR5 combined with C46 HIV-1 fusion inhibitor for cellular resistant to R5 and X4 tropic HIV-1. Khamaikawin W, Saisawang C, Tassaneetrithep B, Bhukhai K, Phanthong P, Borwornpinyo S, Phuphuakrat A, Pasomsub E, Chaisavaneeyakorn S, Anurathapan U, Apiwattanakul N, Hongeng S. Sci Rep. 2024 May 13;14(1):10852. doi: 10.1038/s41598-024-61626-x. PubMed |
| Comparing chemical transfection, electroporation, and lentiviral vector transduction to achieve optimal transfection conditions in the Vero cell line. Jamour P, Jamali A, Langeroudi AG, Sharafabad BE, Abdoli A. BMC Mol Cell Biol. 2024 May 13;25(1):15. doi: 10.1186/s12860-024-00511-x. PubMed |
| ALK inhibitors suppress HCC and synergize with anti-PD-1 therapy and ABT-263 in preclinical models. Bugide S, Reddy DS, Malvi P, Gupta R, Wajapeyee N. iScience. 2024 Apr 23;27(5):109800. doi: 10.1016/j.isci.2024.109800. eCollection 2024 May 17. PubMed |
| FBXO22 is a potential therapeutic target for recurrent chondrosarcoma. Xin B, Chen H, Zhu Z, Guan Q, Bai G, Yang C, Zou W, Gao X, Li L, Liu T. J Bone Oncol. 2024 May 1;46:100605. doi: 10.1016/j.jbo.2024.100605. eCollection 2024 Jun. PubMed |
| Genome-wide CRISPR screens in spheroid culture reveal that the tumor suppressor LKB1 inhibits growth via the PIKFYVE lipid kinase. Ferrarone JR, Thomas J, Unni AM, Zheng Y, Nagiec MJ, Gardner EE, Mashadova O, Li K, Koundouros N, Montalbano A, Mustafa M, Cantley LC, Blenis J, Sanjana NE, Varmus H. Proc Natl Acad Sci U S A. 2024 May 21;121(21):e2403685121. doi: 10.1073/pnas.2403685121. Epub 2024 May 14. PubMed |
| mTORC1 regulates cell survival under glucose starvation through 4EBP1/2-mediated translational reprogramming of fatty acid metabolism. Levy T, Voeltzke K, Hruby L, Alasad K, Bas Z, Snaebjornsson M, Marciano R, Scharov K, Planque M, Vriens K, Christen S, Funk CM, Hassiepen C, Kahler A, Heider B, Picard D, Lim JKM, Stefanski A, Bendrin K, Vargas-Toscano A, Kahlert UD, Stuhler K, Remke M, Elkabets M, Grunewald TGP, Reichert AS, Fendt SM, Schulze A, Reifenberger G, Rotblat B, Leprivier G. Nat Commun. 2024 May 14;15(1):4083. doi: 10.1038/s41467-024-48386-y. PubMed |
| Conserved role of hnRNPL in alternative splicing of epigenetic modifiers enables B cell activation. Subramani PG, Fraszczak J, Helness A, Estall JL, Moroy T, Di Noia JM. EMBO Rep. 2024 Jun;25(6):2662-2697. doi: 10.1038/s44319-024-00152-3. Epub 2024 May 14. PubMed |
| PSMD9 promotes the malignant progression of hepatocellular carcinoma by interacting with c-Cbl to activate EGFR signaling and recycling. Su Y, Meng L, Ge C, Liu Y, Zhang C, Yang Y, Tian W, Tian H. J Exp Clin Cancer Res. 2024 May 14;43(1):142. doi: 10.1186/s13046-024-03062-3. PubMed |
CRISPR-Cas13d screens identify KILR, a breast cancer risk-associated lncRNA that regulates DNA replication and repair.
Wang L, Bitar M, Lu X, Jacquelin S, Nair S, Sivakumaran H, Hillman KM, Kaufmann S, Ziegman R, Casciello F, Gowda H, Rosenbluh J, Edwards SL, French JD.
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PubMed
Associated Plasmids |
| PAX6 promotes neuroendocrine phenotypes of prostate cancer via enhancing MET/STAT5A-mediated chromatin accessibility. Jing N, Du X, Liang Y, Tao Z, Bao S, Xiao H, Dong B, Gao WQ, Fang YX. J Exp Clin Cancer Res. 2024 May 15;43(1):144. doi: 10.1186/s13046-024-03064-1. PubMed |
| Interferon-Inducible Guanylate-Binding Protein 5 Inhibits Replication of Multiple Viruses by Binding to the Oligosaccharyltransferase Complex and Inhibiting Glycoprotein Maturation. Wang S, Li W, Wang L, Tiwari SK, Bray W, Wu L, Li N, Hui H, Clark AE, Zhang Q, Zhang L, Carlin AF, Rana TM. bioRxiv [Preprint]. 2024 May 3:2024.05.01.591800. doi: 10.1101/2024.05.01.591800. PubMed |
| The general transcription factor TFIIB is a target for transcriptome control during cellular stress and viral infection. Gulyas L, Glaunsinger BA. bioRxiv [Preprint]. 2024 May 3:2024.01.16.575933. doi: 10.1101/2024.01.16.575933. PubMed |
| Oncogene EVI1 drives acute myeloid leukemia via a targetable interaction with CTBP2. Pastoors D, Havermans M, Mulet-Lazaro R, Brian D, Noort W, Grasel J, Hoogenboezem R, Smeenk L, Demmers JAA, Milsom MD, Enver T, Groen RWJ, Bindels E, Delwel R. Sci Adv. 2024 May 17;10(20):eadk9076. doi: 10.1126/sciadv.adk9076. Epub 2024 May 15. PubMed |
| Expression of the membrane tetraspanin claudin 18 on cancer cells promotes T lymphocyte infiltration and antitumor immunity in pancreatic cancer. De Sanctis F, Dusi S, Caligola S, Anselmi C, Petrova V, Rossi B, Angelini G, Erdeljan M, Woll S, Schlitter AM, Metzler T, Steiger K, Borok Z, Bailey P, Bauer A, Halin C, Boschi F, Giugno R, Cane S, Lawlor R, Corbo V, Scarpa A, Constantin G, Ugel S, Vascotto F, Sahin U, Tureci O, Bronte V. Immunity. 2024 Jun 11;57(6):1378-1393.e14. doi: 10.1016/j.immuni.2024.04.021. Epub 2024 May 14. PubMed |
| HPV16-miRNAs exert oncogenic effects through enhancers in human cervical cancer. Wang Y, Wang X, Liu Y, He Y, Duan X, Li Q, Huang Y, Xu G, Lu Q. Cancer Cell Int. 2024 May 15;24(1):172. doi: 10.1186/s12935-024-03364-8. PubMed |
| Sex- and species-specific contribution of CD99 to T cell costimulation during multiple sclerosis. Winschel I, Willing A, Engler JB, Walkenhorst M, Meurs N, Binkle-Ladisch L, Woo MS, Pfeffer LK, Sonner JK, Borgmeyer U, Hagen SH, Grunhagel B, Claussen JM, Altfeld M, Friese MA. Biol Sex Differ. 2024 May 15;15(1):41. doi: 10.1186/s13293-024-00618-y. PubMed |
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Crosstalk between Regnase-1 and -3 shapes mast cell survival and cytokine expression.
Bataclan M, Leoni C, Moro SG, Pecoraro M, Wong EH, Heissmeyer V, Monticelli S.
Life Sci Alliance. 2024 Jun 3;7(8):e202402784. doi: 10.26508/lsa.202402784. Print 2024 Aug.
PubMed
Associated Plasmids |
| PPIA dictates NRF2 stability to promote lung cancer progression. Lu W, Cui J, Wang W, Hu Q, Xue Y, Liu X, Gong T, Lu Y, Ma H, Yang X, Feng B, Wang Q, Zhang N, Xu Y, Liu M, Nussinov R, Cheng F, Ji H, Huang J. Nat Commun. 2024 Jun 3;15(1):4703. doi: 10.1038/s41467-024-48364-4. PubMed |
| The small tumor antigen of Merkel cell polyomavirus accomplishes cellular transformation by uniquely localizing to the nucleus despite the absence of a known nuclear localization signal. Thevenin KR, Tieche IS, Di Benedetto CE, Schrager M, Dye KN. Virol J. 2024 Jun 3;21(1):125. doi: 10.1186/s12985-024-02395-x. PubMed |
| Identification of an HLA-A*11:01-restricted neoepitope of mutant PIK3CA and its specific T cell receptors for cancer immunotherapy targeting hotspot driver mutations. Shen M, Chen S, Han X, Hao Y, Wang J, Li L, Chen T, Wang B, Zou L, Zhang T, Zhang W, Han X, Wang W, Yu H, Li K, Liu S, Jin A. Cancer Immunol Immunother. 2024 Jun 4;73(8):150. doi: 10.1007/s00262-024-03729-y. PubMed |
| Cancer-specific epigenome identifies oncogenic hijacking by nuclear factor I family proteins for medulloblastoma progression. Shiraishi R, Cancila G, Kumegawa K, Torrejon J, Basili I, Bernardi F, Silva PBGD, Wang W, Chapman O, Yang L, Jami M, Nishitani K, Arai Y, Xiao Z, Yu H, Lo Re V, Marsaud V, Talbot J, Lombard B, Loew D, Jingu M, Okonechnikov K, Sone M, Motohashi N, Aoki Y, Pfister SM, Chavez L, Hoshino M, Maruyama R, Ayrault O, Kawauchi D. Dev Cell. 2024 May 31:S1534-5807(24)00330-7. doi: 10.1016/j.devcel.2024.05.013. PubMed |
| Decreased Tiam1-mediated Rac1 activation is responsible for impaired directional persistence of chondrocyte migration in microtia. Wu Y, Liu W, Li J, Shi H, Ma S, Wang D, Pan B, Xiao R, Jiang H, Liu X. J Cell Mol Med. 2024 Jun;28(11):e18443. doi: 10.1111/jcmm.18443. PubMed |
| A targetable PRR11-DHODH axis drives ferroptosis- and temozolomide-resistance in glioblastoma. Miao Z, Xu L, Gu W, Ren Y, Li R, Zhang S, Chen C, Wang H, Ji J, Chen J. Redox Biol. 2024 Jul;73:103220. doi: 10.1016/j.redox.2024.103220. Epub 2024 May 30. PubMed |
| Targeting dependency on a paralog pair of CBP/p300 against de-repression of KREMEN2 in SMARCB1-deficient cancers. Sasaki M, Kato D, Murakami K, Yoshida H, Takase S, Otsubo T, Ogiwara H. Nat Commun. 2024 Jun 5;15(1):4770. doi: 10.1038/s41467-024-49063-w. PubMed |
| Targeting the DYRK1A kinase prevents cancer progression and metastasis and promotes cancer cells response to G1/S targeting chemotherapy drugs. Laham AJ, El-Awady R, Saber-Ayad M, Wang N, Yan G, Boudreault J, Ali S, Lebrun JJ. NPJ Precis Oncol. 2024 Jun 5;8(1):128. doi: 10.1038/s41698-024-00614-w. PubMed |
| DUSP4 enhances therapeutic sensitivity in HER2-positive breast cancer by inhibiting the G6PD pathway and ROS metabolism by interacting with ALDOB. Wang X, Chi W, Ma Y, Zhang Q, Xue J, Shao ZM, Xiu B, Wu J, Chi Y. Transl Oncol. 2024 Aug;46:102016. doi: 10.1016/j.tranon.2024.102016. Epub 2024 Jun 5. PubMed |
| The ribotoxic stress response drives UV-mediated cell death. Sinha NK, McKenney C, Yeow ZY, Li JJ, Nam KH, Yaron-Barir TM, Johnson JL, Huntsman EM, Cantley LC, Ordureau A, Regot S, Green R. Cell. 2024 Jul 11;187(14):3652-3670.e40. doi: 10.1016/j.cell.2024.05.018. Epub 2024 Jun 5. PubMed |
| A CD36-dependent non-canonical lipid metabolism program promotes immune escape and resistance to hypomethylating agent therapy in AML. Guo HZ, Feng RX, Zhang YJ, Yu YH, Lu W, Liu JJ, Yang SX, Zhao C, Zhang ZL, Yu SH, Jin H, Qian SX, Li JY, Zhu J, Shi J. Cell Rep Med. 2024 Jun 18;5(6):101592. doi: 10.1016/j.xcrm.2024.101592. Epub 2024 Jun 5. PubMed |
| NSUN2/YBX1 promotes the progression of breast cancer by enhancing HGH1 mRNA stability through m(5)C methylation. Zhang X, An K, Ge X, Sun Y, Wei J, Ren W, Wang H, Wang Y, Du Y, He L, Li O, Zhou S, Shi Y, Ren T, Yang YG, Kan Q, Tian X. Breast Cancer Res. 2024 Jun 6;26(1):94. doi: 10.1186/s13058-024-01847-0. PubMed |
| Time-resolved fate mapping identifies the intestinal upper crypt zone as an origin of Lgr5+ crypt base columnar cells. Capdevila C, Miller J, Cheng L, Kornberg A, George JJ, Lee H, Botella T, Moon CS, Murray JW, Lam S, Calderon RI, Malagola E, Whelan G, Lin CS, Han A, Wang TC, Sims PA, Yan KS. Cell. 2024 Jun 6;187(12):3039-3055.e14. doi: 10.1016/j.cell.2024.05.001. PubMed |
| Atlastin-1 regulates endosomal tubulation and lysosomal proteolysis in human cortical neurons. Zlamalova E, Rodger C, Greco F, Cheers SR, Kleniuk J, Nadadhur AG, Kadlecova Z, Reid E. Neurobiol Dis. 2024 Sep;199:106556. doi: 10.1016/j.nbd.2024.106556. Epub 2024 Jun 6. PubMed |
| Pure estrogen receptor antagonists potentiate capecitabine activity in ESR1-mutant breast cancer. Grinshpun A, Russo D, Ma W, Verma A, Hermida-Prado F, Sherman S, Gaglia G, Kabraji S, Kirkner G, Hughes ME, Lin NU, Sandusky Z, Nardone A, Guarducci C, Nguyen QD, Santagata S, Nagy Z, Jeselsohn R. NPJ Breast Cancer. 2024 Jun 8;10(1):42. doi: 10.1038/s41523-024-00647-1. PubMed |
| Tumour-derived Extracellular Vesicle and Particle Reprogramming of Interstitial Macrophages in the Lung Pre-Metastatic Niche Enhances Vascular Permeability and Metastatic Potential. Dror S, Lucotti S, Asao T, Li J, Wortzel I, Berger LS, Matei I, Boudreau N, Zhang H, Jones D, Bromberg J, Lyden D. Res Sq [Preprint]. 2024 May 30:rs.3.rs-4462139. doi: 10.21203/rs.3.rs-4462139/v1. PubMed |
| SLO2.1/NALCN Functional Complex Activity in Mouse Myometrial Smooth Muscle Cells During Pregnancy. Ferreira JJ, Kent LN, McCarthy R, Butler A, Ma X, Peramsetty N, Amazu C, Zhang A, Whitter GC, England SK, Santi CM. bioRxiv [Preprint]. 2024 Jun 2:2024.05.29.596465. doi: 10.1101/2024.05.29.596465. PubMed |
| The epithelial adherens junction component PLEKHA7 regulates ECM remodeling and cell behavior through miRNA-mediated regulation of MMP1 and LOX. Daulagala AC, Cetin M, Nair-Menon J, Jimenez DW, Bridges MC, Bradshaw AD, Sahin O, Kourtidis A. bioRxiv [Preprint]. 2024 May 30:2024.05.28.596237. doi: 10.1101/2024.05.28.596237. PubMed |
| Emergence of activation or repression in transcriptional control under a fixed molecular context. Martinez-Corral R, Friedrich D, Fromel R, Velten L, Gunawardena J, DePace AH. bioRxiv [Preprint]. 2024 Jun 2:2024.05.29.596388. doi: 10.1101/2024.05.29.596388. PubMed |
| Engineered Self-Regulating Macrophages for Targeted Anti-inflammatory Drug Delivery. Klimak M, Cimino A, Lenz K, Springer L, Collins K, Harasymowicz N, Xu N, Pham C, Guilak F. Res Sq [Preprint]. 2024 May 31:rs.3.rs-4385938. doi: 10.21203/rs.3.rs-4385938/v1. PubMed |
| Neratinib, a pan ERBB/HER inhibitor, restores sensitivity of PTEN-null, BRAFV600E melanoma to BRAF/MEK inhibition. DuBose E, Bevill SM, Mitchell DK, Sciaky N, Golitz BT, Dixon SAH, Rhodes SD, Bear JE, Johnson GL, Angus SP. Front Oncol. 2024 May 16;14:1191217. doi: 10.3389/fonc.2024.1191217. eCollection 2024. PubMed |
| Retrotransposons in Werner syndrome-derived macrophages trigger type I interferon-dependent inflammation in an atherosclerosis model. Paul SK, Oshima M, Patil A, Sone M, Kato H, Maezawa Y, Kaneko H, Fukuyo M, Rahmutulla B, Ouchi Y, Tsujimura K, Nakanishi M, Kaneda A, Iwama A, Yokote K, Eto K, Takayama N. Nat Commun. 2024 Jun 10;15(1):4772. doi: 10.1038/s41467-024-48663-w. PubMed |
| MYG1 drives glycolysis and colorectal cancer development through nuclear-mitochondrial collaboration. Chen J, Duan S, Wang Y, Ling Y, Hou X, Zhang S, Liu X, Long X, Lan J, Zhou M, Xu H, Zheng H, Zhou J. Nat Commun. 2024 Jun 11;15(1):4969. doi: 10.1038/s41467-024-49221-0. PubMed |
| The integrin CD11b inhibits MSU-induced NLRP3 inflammasome activation in macrophages and protects mice against MSU-induced joint inflammation. Ehirchiou D, Bernabei I, Pandian VD, Nasi S, Chobaz V, Castelblanco M, So A, Martinon F, Li X, Acha-Orbea H, Hugle T, Zhang L, Busso N. Arthritis Res Ther. 2024 Jun 11;26(1):119. doi: 10.1186/s13075-024-03350-5. PubMed |
| SGIP1 binding to the alpha-helical H9 domain of cannabinoid receptor 1 promotes axonal surface expression. Fletcher-Jones A, Spackman E, Craig TJ, Nakamura Y, Wilkinson KA, Henley JM. J Cell Sci. 2024 Jun 1;137(11):jcs261551. doi: 10.1242/jcs.261551. Epub 2024 Jun 12. PubMed |
| GD2 and its biosynthetic enzyme GD3 synthase promote tumorigenesis in prostate cancer by regulating cancer stem cell behavior. Bhat AM, Mohapatra BC, Luan H, Mushtaq I, Chakraborty S, Kumar S, Wu W, Nolan B, Dutta S, Storck MD, Schott M, Meza JL, Lele SM, Lin MF, Cook LM, Corey E, Morrissey C, Coulter DW, Rowley MJ, Natarajan A, Datta K, Band V, Band H. Sci Rep. 2024 Jun 12;14(1):13523. doi: 10.1038/s41598-024-60052-3. PubMed |
| APOBEC3-related mutations in the spike protein-encoding region facilitate SARS-CoV-2 evolution. Shen J, Xu X, Fan J, Chen H, Zhao Y, Huang W, Liu W, Zhang Z, Cui Q, Li Q, Niu Z, Jiang D, Cao G. Heliyon. 2024 May 29;10(11):e32139. doi: 10.1016/j.heliyon.2024.e32139. eCollection 2024 Jun 15. PubMed |
| Transcriptional synergy in human aortic endothelial cells is vulnerable to combination p300/CBP and BET bromodomain inhibition. Bracken RC, Davison LM, Buehler DP, Fulton ME, Carson EE, Sheng Q, Stolze LK, Guillermier C, Steinhauser ML, Brown JD. iScience. 2024 May 16;27(6):110011. doi: 10.1016/j.isci.2024.110011. eCollection 2024 Jun 21. PubMed |
| Epigenomic signatures of sarcomatoid differentiation to guide the treatment of renal cell carcinoma. El Zarif T, Semaan K, Eid M, Seo JH, Garinet S, Davidsohn MP, Sahgal P, Fortunato B, Canniff J, Nassar AH, Abou Alaiwi S, Bakouny Z, Lakshminarayanan G, Savignano H, Lyons K, Matar S, Ali A, Saad E, Saliby RM, Cordeiro P, Zhang Z, El Ahmar N, Laimon YN, Labaki C, Shah V, Freeman D, O'Toole J, Lee GM, Hwang J, Pomerantz M, Signoretti S, Van Allen EM, Xie W, Berchuck JE, Viswanathan SR, Braun DA, Choueiri TK, Freedman ML, Baca SC. Cell Rep. 2024 Jun 25;43(6):114350. doi: 10.1016/j.celrep.2024.114350. Epub 2024 Jun 12. PubMed |
| Collagen density regulates tip-stalk cell rearrangement during angiogenesis via cellular bioenergetics. Wang W, Zanotelli MR, Sabo LN, Fabiano ED, Goldfield NM, Le C, Techasiriwan EP, Lopez S, Berestesky ED, Reinhart-King CA. APL Bioeng. 2024 Jun 10;8(2):026120. doi: 10.1063/5.0195249. eCollection 2024 Jun. PubMed |
| Targeted eradication of EBV-positive cancer cells by CRISPR/dCas9-mediated EBV reactivation in combination with ganciclovir. Sugiokto FG, Li R. mBio. 2024 Jul 17;15(7):e0079524. doi: 10.1128/mbio.00795-24. Epub 2024 Jun 14. PubMed |
| UM171 suppresses breast cancer progression by inducing KLF2. Ran X, Hu A, Kuang Y, Wang C, Liu W, Xiao X, Zacksenhaus E, Yu X, Ben-David Y. Breast Cancer Res Treat. 2024 Sep;207(2):405-415. doi: 10.1007/s10549-024-07372-0. Epub 2024 Jun 14. PubMed |
| Cadherin-11 contributes to the heterogenous and dynamic Wnt-Wnt-beta-catenin pathway activation in Ewing sarcoma. Shirai R, Biebighauser T, Walker D, Oviedo J, Nelson-Taylor S, Bodlak A, Porfilio T, Oike N, Goodspeed A, Hayashi M. PLoS One. 2024 Jun 14;19(6):e0305490. doi: 10.1371/journal.pone.0305490. eCollection 2024. PubMed |
| Mechanistic patterns and clinical implications of oncogenic tyrosine kinase fusions in human cancers. Cheong TC, Jang A, Wang Q, Leonardi GC, Ricciuti B, Alessi JV, Di Federico A, Awad MM, Lehtinen MK, Harris MH, Chiarle R. Nat Commun. 2024 Jun 14;15(1):5110. doi: 10.1038/s41467-024-49499-0. PubMed |
| STING orchestrates the neuronal inflammatory stress response in multiple sclerosis. Woo MS, Mayer C, Binkle-Ladisch L, Sonner JK, Rosenkranz SC, Shaposhnykov A, Rothammer N, Tsvilovskyy V, Lorenz SM, Raich L, Bal LC, Vieira V, Wagner I, Bauer S, Glatzel M, Conrad M, Merkler D, Freichel M, Friese MA. Cell. 2024 Jul 25;187(15):4043-4060.e30. doi: 10.1016/j.cell.2024.05.031. Epub 2024 Jun 14. PubMed |
| Golgi dispersal in cancer stem cells promotes chemoresistance of colorectal cancer via the Golgi stress response. Li Y, Mu L, Li Y, Mi Y, Hu Y, Li X, Tao D, Qin J. Cell Death Dis. 2024 Jun 15;15(6):417. doi: 10.1038/s41419-024-06817-0. PubMed |
| G6PD and ACSL3 are synthetic lethal partners of NF2 in Schwann cells. Kyrkou A, Valla R, Zhang Y, Ambrosi G, Laier S, Muller-Decker K, Boutros M, Teleman AA. Nat Commun. 2024 Jun 15;15(1):5115. doi: 10.1038/s41467-024-49298-7. PubMed |
| Building a novel TRUCK by harnessing the endogenous IFN-gamma promoter for cytokine expression. Ma L, Zhang K, Xu J, Wang J, Jiang T, Du X, Zhang J, Huang J, Ren F, Liu D, Xue W, Kan D, Yao M, Liang Y, Jason-Sun H. Mol Ther. 2024 Aug 7;32(8):2728-2740. doi: 10.1016/j.ymthe.2024.06.017. Epub 2024 Jun 15. PubMed |
| Tensin 4 facilitates aerobic glycolysis, migration and invasion of colorectal cancer cells through the beta‑catenin/c‑Myc signaling pathway. Wang Y, Lu Y, Xu C. Oncol Lett. 2024 Jun 3;28(2):356. doi: 10.3892/ol.2024.14489. eCollection 2024 Aug. PubMed |
| Tight Junction Component Occludin Binds to FIP5 to Regulate Endosome Trafficking and Mitotic Spindle Function. Zhang Z, Chen J, Ma R, Xu C, Lu Y, Zhou J, Xia K, Lu P. Adv Sci (Weinh). 2024 Aug;11(30):e2308822. doi: 10.1002/advs.202308822. Epub 2024 Jun 17. PubMed |
| A Novel AMPK Inhibitor Sensitizes Pancreatic Cancer Cells to Ferroptosis Induction. Schneider C, Hilbert J, Genevaux F, Hofer S, Krauss L, Schicktanz F, Contreras CT, Jansari S, Papargyriou A, Richter T, Alfayomy AM, Falcomata C, Schneeweis C, Orben F, Ollinger R, Wegwitz F, Boshnakovska A, Rehling P, Muller D, Strobel P, Ellenrieder V, Conradi L, Hessmann E, Ghadimi M, Grade M, Wirth M, Steiger K, Rad R, Kuster B, Sippl W, Reichert M, Saur D, Schneider G. Adv Sci (Weinh). 2024 Aug;11(31):e2307695. doi: 10.1002/advs.202307695. Epub 2024 Jun 17. PubMed |
| Latrophilin-2 mediates fluid shear stress mechanotransduction at endothelial junctions. Tanaka K, Chen M, Prendergast A, Zhuang Z, Nasiri A, Joshi D, Hintzen J, Chung M, Kumar A, Mani A, Koleske A, Crawford J, Nicoli S, Schwartz MA. EMBO J. 2024 Aug;43(15):3175-3191. doi: 10.1038/s44318-024-00142-0. Epub 2024 Jun 17. PubMed |
| DUSP6 inhibition overcomes neuregulin/HER3-driven therapy tolerance in HER2+ breast cancer. Momeny M, Tienhaara M, Sharma M, Chakroborty D, Varjus R, Takala I, Merisaari J, Padzik A, Vogt A, Paatero I, Elenius K, Laajala TD, Kurppa KJ, Westermarck J. EMBO Mol Med. 2024 Jul;16(7):1603-1629. doi: 10.1038/s44321-024-00088-0. Epub 2024 Jun 17. PubMed |
| Sterol-like drugs potentiate statin-triggered prostate cancer cell death by inhibiting SREBP2 nuclear translocation. Dos Santos DZ, Elbaz M, Branchard E, Schormann W, Brown CE, Meek AR, Njar VCO, Hamilton RJ, Reed MA, Andrews DW, Penn LZ. Biomed Pharmacother. 2024 Aug;177:116934. doi: 10.1016/j.biopha.2024.116934. Epub 2024 Jun 17. PubMed |
| Integrative genomics identifies SHPRH as a tumor suppressor gene in lung adenocarcinoma that regulates DNA damage response. Nagelberg AL, Sihota TS, Chuang YC, Shi R, Chow JLM, English J, MacAulay C, Lam S, Lam WL, Lockwood WW. Br J Cancer. 2024 Aug;131(3):534-550. doi: 10.1038/s41416-024-02755-y. Epub 2024 Jun 18. PubMed |
| gamma-secretase facilitates retromer-mediated retrograde transport. Takeo Y, Crite M, DiMaio D. bioRxiv [Preprint]. 2024 Jun 7:2024.06.07.597932. doi: 10.1101/2024.06.07.597932. PubMed |
| Crosstalk of MAP3K1 and EGFR signaling mediates gene-environment interactions that block developmental tissue closure. Wang J, Xiao B, Kimura E, Mongan M, Hsu WW, Medvedovic M, Puga A, Xia Y. J Biol Chem. 2024 Jul;300(7):107486. doi: 10.1016/j.jbc.2024.107486. Epub 2024 Jun 18. PubMed |
| Therapy-induced secretion of spliceosomal components mediates pro-survival crosstalk between ovarian cancer cells. Shender VO, Anufrieva KS, Shnaider PV, Arapidi GP, Pavlyukov MS, Ivanova OM, Malyants IK, Stepanov GA, Zhuravlev E, Ziganshin RH, Butenko IO, Bukato ON, Klimina KM, Veselovsky VA, Grigorieva TV, Malanin SY, Aleshikova OI, Slonov AV, Babaeva NA, Ashrafyan LA, Khomyakova E, Evtushenko EG, Lukina MM, Wang Z, Silantiev AS, Nushtaeva AA, Kharlampieva DD, Lazarev VN, Lashkin AI, Arzumanyan LK, Petrushanko IY, Makarov AA, Lebedeva OS, Bogomazova AN, Lagarkova MA, Govorun VM. Nat Commun. 2024 Jun 19;15(1):5237. doi: 10.1038/s41467-024-49512-6. PubMed |
| Novel role of NCoR1 in impairing spatial memory through the mediation of a novel interacting protein DEC2. Cheng KM, Hsu WL, Ma YL, Liu YC, Lee EHY. Cell Mol Life Sci. 2024 Jun 20;81(1):273. doi: 10.1007/s00018-024-05321-0. PubMed |
| RUVBL1/2 Blockade Targets YTHDF1 Activity to Suppress m6A-Dependent Oncogenic Translation and Colorectal Tumorigenesis. Chen D, Ji F, Zhou Q, Cheung H, Pan Y, Lau HC, Liang C, Yang Z, Huang P, Wei Q, Cheung AH, Kang W, Chen H, Yu J, Wong CC. Cancer Res. 2024 Sep 4;84(17):2856-2872. doi: 10.1158/0008-5472.CAN-23-2081. PubMed |
| CREB1 promotes expression of immune checkpoint HLA-E leading to immune escape in multiple myeloma. Ismael A, Robinette AJ, Huric L, Schuetz J, Dona K, Benson D, Cocucci E, Cottini F. Leukemia. 2024 Aug;38(8):1777-1786. doi: 10.1038/s41375-024-02303-w. Epub 2024 Jun 20. PubMed |
| Metallothionein 3 Potentiates Pulmonary Artery Smooth Muscle Cell Proliferation by Promoting Zinc-MTF1-ATG5 Axis-mediated Autophagosome Formation. Xiong T, Li Y, Yang M, Huo B, Guo X, Liu L, Huang Y, Zhu X, Hu Q, Wei X, Jiang DS, Yi X. Int J Biol Sci. 2024 May 11;20(8):2904-2921. doi: 10.7150/ijbs.92992. eCollection 2024. PubMed |
| The receptor protein tyrosine phosphatase PTPRK promotes intestinal repair and catalysis-independent tumour suppression. Young KA, Wojdyla K, Lai T, Mulholland KE, Aldaz Casanova S, Antrobus R, Andrews SR, Biggins L, Mahler-Araujo B, Barton PR, Anderson KR, Fearnley GW, Sharpe HJ. J Cell Sci. 2024 Jul 15;137(14):jcs261914. doi: 10.1242/jcs.261914. Epub 2024 Jul 22. PubMed |
| ELM2-SANT Domain-Containing Scaffolding Protein 1 Regulates Differentiation and Maturation of Cardiomyocytes Derived From Human-Induced Pluripotent Stem Cells. Lu YA, Sun J, Wang L, Wang M, Wu Y, Getachew A, Matthews RC, Li H, Peng WG, Zhang J, Lu R, Zhou Y. J Am Heart Assoc. 2024 Jul 2;13(13):e034816. doi: 10.1161/JAHA.124.034816. Epub 2024 Jun 21. PubMed |
| Widespread chromatin context-dependencies of DNA double-strand break repair proteins. Vergara X, Manjon AG, de Haas M, Morris B, Schep R, Leemans C, Friskes A, Beijersbergen RL, Sanders MA, Medema RH, van Steensel B. Nat Commun. 2024 Jun 22;15(1):5334. doi: 10.1038/s41467-024-49232-x. PubMed |
| Protocol to identify defined reprogramming factor expression using a factor-indexing single-nuclei multiome sequencing approach. Fei L, Zhang K, Hautaniemi S, Sahu B. STAR Protoc. 2024 Sep 20;5(3):103148. doi: 10.1016/j.xpro.2024.103148. Epub 2024 Jun 22. PubMed |
| A highly effective ferritin-based divalent nanoparticle vaccine shields Syrian hamsters against lethal Nipah virus. Yin C, Yao YF, Yang P, Liu H, Gao G, Peng Y, Chen M, Lu M, Zhang X, Guo W, Zhang Z, Hu X, Yuan Z, Shan C. Front Immunol. 2024 Jun 6;15:1387811. doi: 10.3389/fimmu.2024.1387811. eCollection 2024. PubMed |
| Reduced decay-accelerating factor expression promotes complement-mediated cystogenesis in murine ADPKD. Bin S, Yoo M, Molinari P, Gentile M, Budge K, Cantarelli C, Khan Y, La Manna G, Baldwin WM, Dvorina N, Cravedi P, Gusella GL. JCI Insight. 2024 May 23;9(12):e175220. doi: 10.1172/jci.insight.175220. PubMed |
| SMAD4 depletion contributes to endocrine resistance by integrating ER and ERBB signaling in HR + HER2- breast cancer. Li K, Shu D, Li H, Lan A, Zhang W, Tan Z, Huang M, Tomasi ML, Jin A, Yu H, Shen M, Liu S. Cell Death Dis. 2024 Jun 24;15(6):444. doi: 10.1038/s41419-024-06838-9. PubMed |
| Injury-induced Foxm1 expression in the mouse kidney drives epithelial proliferation by a cyclin F-dependent mechanism. Noonan ML, Muto Y, Yoshimura Y, Leckie-Harre A, Wu H, Kalinichenko VV, Humphreys BD, Chang-Panesso M. JCI Insight. 2024 Jun 25;9(15):e175416. doi: 10.1172/jci.insight.175416. PubMed |
An efficient plasmid-based system for the recovery of recombinant vesicular stomatitis virus encoding foreign glycoproteins.
Marques MC, Andreu-Moreno I, Sanjuan R, Elena SF, Geller R.
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PubMed
Associated Plasmids |
| Hypoxia-Induced Long Noncoding RNA HIF1A-AS2 Regulates Stability of MHC Class I Protein in Head and Neck Cancer. Liao TT, Chen YH, Li ZY, Hsiao AC, Huang YL, Hao RX, Tai SK, Chu PY, Shih JW, Kung HJ, Yang MH. Cancer Immunol Res. 2024 Oct 1;12(10):1468-1484. doi: 10.1158/2326-6066.CIR-23-0622. PubMed |
| Use of FRET-Sensor 'Mermaid' to Detect Subtle Changes in Membrane Potential of Primary Mouse PASMCs. Dartsch RC, Kraut S, Mayer T, Gabel A, Dietrich A, Weissmann N, Fuchs B, Knoepp F. Cells. 2024 Jun 20;13(12):1070. doi: 10.3390/cells13121070. PubMed |
| Systematic transcriptome profiling of hPSC-derived osteoblasts unveils CORIN's mastery in governing osteogenesis through CEBPD modulation. Zhu D, Huang MF, Xu A, Gao X, Huang YW, Phan TTT, Lu L, Chi TY, Dai Y, Pang LK, Gingold JA, Tu J, Huo Z, Bazer DA, Shoemaker R, Wang J, Ambrose CG, Shen J, Kameoka J, Zhao Z, Wang LL, Zhang Y, Zhao R, Lee DF. J Biol Chem. 2024 Aug;300(8):107494. doi: 10.1016/j.jbc.2024.107494. Epub 2024 Jun 24. PubMed |
| Alkylamine-tethered molecules recruit FBXO22 for targeted protein degradation. Kagiou C, Cisneros JA, Farnung J, Liwocha J, Offensperger F, Dong K, Yang K, Tin G, Horstmann CS, Hinterndorfer M, Paulo JA, Scholes NS, Sanchez Avila J, Fellner M, Andersch F, Hannich JT, Zuber J, Kubicek S, Gygi SP, Schulman BA, Winter GE. Nat Commun. 2024 Jun 26;15(1):5409. doi: 10.1038/s41467-024-49739-3. PubMed |
| METTL3-mediated chromatin contacts promote stress granule phase separation through metabolic reprogramming during senescence. Wang C, Tanizawa H, Hill C, Havas A, Zhang Q, Liao L, Hao X, Lei X, Wang L, Nie H, Qi Y, Tian B, Gardini A, Kossenkov AV, Goldman A, Berger SL, Noma KI, Adams PD, Zhang R. Nat Commun. 2024 Jun 26;15(1):5410. doi: 10.1038/s41467-024-49745-5. PubMed |
| Nuclear rupture induced by capillary constriction forces promotes differential effects on metastatic and normal breast cells. Perea Paizal J, Au SH, Bakal C. Sci Rep. 2024 Jun 26;14(1):14793. doi: 10.1038/s41598-024-64733-x. PubMed |
| CBP/P300 Inhibition Impairs CD4+ T Cell Activation: Implications for Autoimmune Disorders. Picavet LW, Samat AAK, Calis J, Nijhuis L, Scholman R, Mokry M, Tough DF, Prinjha RK, Vastert SJ, van Loosdregt J. Biomedicines. 2024 Jun 18;12(6):1344. doi: 10.3390/biomedicines12061344. PubMed |
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| Modeling of Intracellular Taurine Levels Associated with Ovarian Cancer Reveals Activation of p53, ERK, mTOR and DNA-Damage-Sensing-Dependent Cell Protection. Centeno D, Farsinejad S, Kochetkova E, Volpari T, Gladych-Macioszek A, Klupczynska-Gabryszak A, Polotaye T, Greenberg M, Kung D, Hyde E, Alshehri S, Pavlovic T, Sullivan W, Plewa S, Vakifahmetoglu-Norberg H, Monsma FJ Jr, Muller PAJ, Matysiak J, Zaborowski MP, DiFeo A, Norberg E, Martin LA, Iwanicki M. Nutrients. 2024 Jun 9;16(12):1816. doi: 10.3390/nu16121816. PubMed |
| Tripartite Motif-Containing Protein 65 (TRIM65) Inhibits Hepatitis B Virus Transcription. Shen S, Yan R, Xie Z, Yu X, Liang H, You Q, Zhang H, Hou J, Zhang X, Liu Y, Sun J, Guo H. Viruses. 2024 May 31;16(6):890. doi: 10.3390/v16060890. PubMed |
| ONECUT2 acts as a lineage plasticity driver in adenocarcinoma as well as neuroendocrine variants of prostate cancer. Qian C, Yang Q, Rotinen M, Huang R, Kim H, Gallent B, Yan Y, Cadaneanu RM, Zhang B, Kaochar S, Freedland SJ, Posadas EM, Ellis L, Di Vizio D, Morrissey C, Nelson PS, Brady L, Murali R, Campbell MJ, Yang W, Knudsen BS, Mostaghel EA, Ye H, Garraway IP, You S, Freeman MR. Nucleic Acids Res. 2024 Jul 22;52(13):7740-7760. doi: 10.1093/nar/gkae547. PubMed |
| Casein kinase 1alpha mediates phosphorylation of the Merkel cell polyomavirus large T antigen for beta-TrCP destruction complex interaction and subsequent degradation. Pham AM, Kwun HJ. mBio. 2024 Aug 14;15(8):e0111724. doi: 10.1128/mbio.01117-24. Epub 2024 Jun 28. PubMed |
| MicroRNA-384 radiosensitizes human non-small cell lung cancer by impairing DNA damage response and repair signaling, which is inhibited by NF-kappaB. Sun Y, Wang J, Qiu M, Zhao J, Zou F, Meng M, Jiang X, Yuan Z, Mi Z, Wu Z. Cancer Biol Med. 2024 Jun 27;21(11):1050-66. doi: 10.20892/j.issn.2095-3941.2024.0146. PubMed |
| PRPF40A induces inclusion of exons in GC-rich regions important for human myeloid cell differentiation. Tan CW, Sim DY, Zhen Y, Tian H, Koh J, Roca X. Nucleic Acids Res. 2024 Aug 27;52(15):8800-8814. doi: 10.1093/nar/gkae557. PubMed |
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| TRMT10A dysfunction perturbs codon translation of initiator methionine and glutamine and impairs brain functions in mice. Tresky R, Miyamoto Y, Nagayoshi Y, Yabuki Y, Araki K, Takahashi Y, Komohara Y, Ge H, Nishiguchi K, Fukuda T, Kaneko H, Maeda N, Matsuura J, Iwasaki S, Sakakida K, Shioda N, Wei FY, Tomizawa K, Chujo T. Nucleic Acids Res. 2024 Aug 27;52(15):9230-9246. doi: 10.1093/nar/gkae520. PubMed |
| YTHDC1 m(6)A-dependent and m(6)A-independent functions converge to preserve the DNA damage response. Elvira-Blazquez D, Fernandez-Justel JM, Arcas A, Statello L, Goni E, Gonzalez J, Ricci B, Zaccara S, Raimondi I, Huarte M. EMBO J. 2024 Aug;43(16):3494-3522. doi: 10.1038/s44318-024-00153-x. Epub 2024 Jul 1. PubMed |
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| IFNgamma mediates the resistance of tumor cells to distinct NK cell subsets. Hofman T, Ng SW, Garces-Lazaro I, Heigwer F, Boutros M, Cerwenka A. J Immunother Cancer. 2024 Jul 1;12(7):e009410. doi: 10.1136/jitc-2024-009410. PubMed |
| YAP1 Suppression by ZDHHC7 Is Associated with Ferroptosis Resistance and Poor Prognosis in Ovarian Clear Cell Carcinoma. Furutake Y, Yamaguchi K, Yamanoi K, Kitamura S, Takamatsu S, Taki M, Ukita M, Hosoe Y, Murakami R, Abiko K, Horie A, Hamanishi J, Baba T, Matsumura N, Mandai M. Mol Cancer Ther. 2024 Nov 4;23(11):1652-1665. doi: 10.1158/1535-7163.MCT-24-0145. PubMed |
| Hsp47 promotes biogenesis of multi-subunit neuroreceptors in the endoplasmic reticulum. Wang YJ, Di XJ, Zhang PP, Chen X, Williams MP, Han DY, Nashmi R, Henderson BJ, Moss FJ, Mu TW. Elife. 2024 Jul 4;13:e84798. doi: 10.7554/eLife.84798. PubMed |
| ALDH1A3-acetaldehyde metabolism potentiates transcriptional heterogeneity in melanoma. Lu Y, Travnickova J, Badonyi M, Rambow F, Coates A, Khan Z, Marques J, Murphy LC, Garcia-Martinez P, Marais R, Louphrasitthiphol P, Chan AHY, Schofield CJ, von Kriegsheim A, Marsh JA, Pavet V, Sansom OJ, Illingworth RS, Patton EE. Cell Rep. 2024 Jul 23;43(7):114406. doi: 10.1016/j.celrep.2024.114406. Epub 2024 Jul 3. PubMed |
| USP9X inhibits metastasis in pulmonary sarcomatoid carcinoma by regulating epithelial-mesenchymal transition, angiogenesis and immune infiltration. Feng Q, Liu Q, Liu Z, Xu J, Yang Y, Zhu Y, Lu G, Xu G, Wu D, Wang F, Liu B, Wang W, Ding X. Transl Oncol. 2024 Sep;47:101950. doi: 10.1016/j.tranon.2024.101950. Epub 2024 Jul 3. PubMed |
| The two-faced role of RNA methyltransferase METTL3 on cellular response to cisplatin in head and neck squamous cell carcinoma in vitro model. Ostrowska K, Rawluszko-Wieczorek AA, Ostapowicz J, Suchorska WM, Golusinski W. Front Oncol. 2024 Jun 19;14:1402126. doi: 10.3389/fonc.2024.1402126. eCollection 2024. PubMed |
Interface-guided phenotyping of coding variants in the transcription factor RUNX1.
Ozturk K, Panwala R, Sheen J, Ford K, Jayne N, Portell A, Zhang DE, Hutter S, Haferlach T, Ideker T, Mali P, Carter H.
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| Elevating PLK1 overcomes BETi resistance in prostate cancer via triggering BRD4 phosphorylation-dependent degradation in mitosis. Zhang Y, Fong KW, Mao F, Wang R, Allison DB, Napier D, He D, Liu J, Zhang Y, Chen J, Kong Y, Li C, Li G, Liu J, Li Z, Zhu H, Wang C, Liu X. Cell Rep. 2024 Jul 23;43(7):114431. doi: 10.1016/j.celrep.2024.114431. Epub 2024 Jul 4. PubMed |
| The septin cytoskeleton is required for plasma membrane repair. Prislusky MI, Lam JGT, Contreras VR, Ng M, Chamberlain M, Pathak-Sharma S, Fields M, Zhang X, Amer AO, Seveau S. EMBO Rep. 2024 Sep;25(9):3870-3895. doi: 10.1038/s44319-024-00195-6. Epub 2024 Jul 5. PubMed |
| Plakophilin 4 controls the spatio-temporal activity of RhoA at adherens junctions to promote cortical actin ring formation and tissue tension. Muller L, Keil R, Glass M, Hatzfeld M. Cell Mol Life Sci. 2024 Jul 6;81(1):291. doi: 10.1007/s00018-024-05329-6. PubMed |
| Early rhombic lip Protogenin(+ve) stem cells in a human-specific neurovascular niche initiate and maintain group 3 medulloblastoma. Visvanathan A, Saulnier O, Chen C, Haldipur P, Orisme W, Delaidelli A, Shin S, Millman J, Bryant A, Abeysundara N, Wu X, Hendrikse LD, Patil V, Bashardanesh Z, Golser J, Livingston BG, Nakashima T, Funakoshi Y, Ong W, Rasnitsyn A, Aldinger KA, Richman CM, Van Ommeren R, Lee JJY, Ly M, Vladoiu MC, Kharas K, Balin P, Erickson AW, Fong V, Zhang J, Suarez RA, Wang H, Huang N, Pallota JG, Douglas T, Haapasalo J, Razavi F, Silvestri E, Sirbu O, Worme S, Kameda-Smith MM, Wu X, Daniels C, MichaelRaj AK, Bhaduri A, Schramek D, Suzuki H, Garzia L, Ahmed N, Kleinman CL, Stein LD, Dirks P, Dunham C, Jabado N, Rich JN, Li W, Sorensen PH, Wechsler-Reya RJ, Weiss WA, Millen KJ, Ellison DW, Dimitrov DS, Taylor MD. Cell. 2024 Aug 22;187(17):4733-4750.e26. doi: 10.1016/j.cell.2024.06.011. Epub 2024 Jul 5. PubMed |
| KAT6A Condensates Impair PARP1 Trapping of PARP Inhibitors in Ovarian Cancer. Zhan Z, Zhang J, Liang H, Wang C, Hong L, Liu W. Adv Sci (Weinh). 2024 Sep;11(34):e2400140. doi: 10.1002/advs.202400140. Epub 2024 Jul 8. PubMed |
| The tyrosine phosphatases LAR and PTPRdelta act as receptors of the nidogen-tetanus toxin complex. Surana S, Villarroel-Campos D, Rhymes ER, Kalyukina M, Panzi C, Novoselov SS, Fabris F, Richter S, Pirazzini M, Zanotti G, Sleigh JN, Schiavo G. EMBO J. 2024 Aug;43(16):3358-3387. doi: 10.1038/s44318-024-00164-8. Epub 2024 Jul 8. PubMed |
| Replicative senescence is ATM driven, reversible, and accelerated by hyperactivation of ATM at normoxia. Stuart A, de Lange T. bioRxiv [Preprint]. 2024 Jun 26:2024.06.24.600514. doi: 10.1101/2024.06.24.600514. PubMed |
| Crosstalk between epitranscriptomic and epigenomic modifications and its implication in human diseases. Li C, Chen K, Fang Q, Shi S, Nan J, He J, Yin Y, Li X, Li J, Hou L, Hu X, Kellis M, Han X, Xiong X. Cell Genom. 2024 Aug 14;4(8):100605. doi: 10.1016/j.xgen.2024.100605. Epub 2024 Jul 8. PubMed |
| A non-canonical role for a small nucleolar RNA in ribosome biogenesis and senescence. Cheng Y, Wang S, Zhang H, Lee JS, Ni C, Guo J, Chen E, Wang S, Acharya A, Chang TC, Buszczak M, Zhu H, Mendell JT. Cell. 2024 Aug 22;187(17):4770-4789.e23. doi: 10.1016/j.cell.2024.06.019. Epub 2024 Jul 8. PubMed |
| The IRE1alpha/XBP1 signaling axis drives myoblast fusion in adult skeletal muscle. Joshi AS, Tomaz da Silva M, Roy A, Koike TE, Wu M, Castillo MB, Gunaratne PH, Liu Y, Iwawaki T, Kumar A. EMBO Rep. 2024 Aug;25(8):3627-3650. doi: 10.1038/s44319-024-00197-4. Epub 2024 Jul 9. PubMed |
| Simple aneuploidy evades p53 surveillance and promotes niche factor-independent growth in human intestinal organoids. Johnson BA, Liu AZ, Bi T, Dong Y, Li T, Zhou D, Narkar A, Wu Y, Sun SX, Larman TC, Zhu J, Li R. Mol Biol Cell. 2024 Aug 1;35(8):br15. doi: 10.1091/mbc.E24-04-0166. Epub 2024 Jul 10. PubMed |
| SART3 reads methylarginine-marked glycine- and arginine-rich motifs. Wang Y, Zhou J, He W, Fu R, Shi L, Dang NK, Liu B, Xu H, Cheng X, Bedford MT. Cell Rep. 2024 Jul 23;43(7):114459. doi: 10.1016/j.celrep.2024.114459. Epub 2024 Jul 9. PubMed |
| Synthetic lethal CRISPR screen identifies a cancer cell-intrinsic role of PD-L1 in regulation of vulnerability to ferroptosis. Feng YY, Li YC, Liu HM, Xu R, Liu YT, Zhang W, Yang HY, Chen G. Cell Rep. 2024 Jul 23;43(7):114477. doi: 10.1016/j.celrep.2024.114477. Epub 2024 Jul 11. PubMed |
Leveraging a self-cleaving peptide for tailored control in proximity labeling proteomics.
Delhaye L, Moschonas GD, Fijalkowska D, Verhee A, De Sutter D, Van de Steene T, De Meyer M, Grzesik H, Van Moortel L, De Bosscher K, Jacobs T, Eyckerman S.
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| Spontaneous and evoked synaptic vesicle release arises from a single releasable pool. Duan J, Kahms M, Steinhoff A, Klingauf J. Cell Rep. 2024 Jul 23;43(7):114461. doi: 10.1016/j.celrep.2024.114461. Epub 2024 Jul 10. PubMed |
| The hydrophobicity of the CARD8 N-terminus tunes inflammasome activation. Tsamouri LP, Hsiao JC, Wang Q, Geeson MB, Huang HC, Nambiar DR, Zou M, Ball DP, Chui AJ, Bachovchin DA. Cell Chem Biol. 2024 Sep 19;31(9):1699-1713.e8. doi: 10.1016/j.chembiol.2024.06.004. Epub 2024 Jul 10. PubMed |
| Metabolic Profiling of Cochlear Organoids Identifies alpha-Ketoglutarate and NAD(+) as Limiting Factors for Hair Cell Reprogramming. Liu Q, Zhang L, Chen Z, He Y, Huang Y, Qiu C, Zhu C, Zhou D, Gan Z, Gao X, Wan G. Adv Sci (Weinh). 2024 Sep;11(34):e2308032. doi: 10.1002/advs.202308032. Epub 2024 Jul 11. PubMed |
| Loss of Lamin A leads to the nuclear translocation of AGO2 and compromised RNA interference. Lobo V, Nowak I, Fernandez C, Correa Muler AI, Westholm JO, Huang HC, Fabrik I, Huynh HT, Shcherbinina E, Poyraz M, Hartlova A, Benhalevy D, Angeletti D, Sarshad AA. Nucleic Acids Res. 2024 Sep 9;52(16):9917-9935. doi: 10.1093/nar/gkae589. PubMed |
| Mutation-induced LZTR1 polymerization provokes cardiac pathology in recessive Noonan syndrome. Busley AV, Gutierrez-Gutierrez O, Hammer E, Koitka F, Mirzaiebadizi A, Steinegger M, Pape C, Bohmer L, Schroeder H, Kleinsorge M, Engler M, Cirstea IC, Gremer L, Willbold D, Altmuller J, Marbach F, Hasenfuss G, Zimmermann WH, Ahmadian MR, Wollnik B, Cyganek L. Cell Rep. 2024 Jul 23;43(7):114448. doi: 10.1016/j.celrep.2024.114448. Epub 2024 Jul 13. PubMed |
| Renal protection after hemorrhagic shock in rats: Possible involvement of SUMOylation. Oliveira FRMB, Sousa Soares E, Pillmann Ramos H, Lattig-Tunnemann G, Harms C, Cimarosti H, Sordi R. Biochem Pharmacol. 2024 Sep;227:116425. doi: 10.1016/j.bcp.2024.116425. Epub 2024 Jul 14. PubMed |
| Reduced adipocyte glutaminase activity promotes energy expenditure and metabolic health. Lecoutre S, Maqdasy S, Rizo-Roca D, Renzi G, Vlassakev I, Alaeddine LM, Higos R, Jalkanen J, Zhong J, Zareifi DS, Frendo-Cumbo S, Massier L, Hodek O, Juvany M, Moritz T, de Castro Barbosa T, Omar-Hmeadi M, Lopez-Yus M, Merabtene F, Abatan JB, Marcelin G, El Hachem EJ, Rouault C, Bergo MO, Petrus P, Zierath JR, Clement K, Krook A, Mejhert N, Ryden M. Nat Metab. 2024 Jul;6(7):1329-1346. doi: 10.1038/s42255-024-01083-y. Epub 2024 Jul 15. PubMed |
| Repression of mRNA translation initiation by GIGYF1 via disrupting the eIF3-eIF4G1 interaction. Choi JH, Luo J, Hesketh GG, Guo S, Pistofidis A, Ladak RJ, An Y, Naeli P, Alain T, Schmeing TM, Gingras AC, Duchaine T, Zhang X, Sonenberg N, Jafarnejad SM. Sci Adv. 2024 Jul 19;10(29):eadl5638. doi: 10.1126/sciadv.adl5638. Epub 2024 Jul 17. PubMed |
| Metformin synergizes with gilteritinib in treating FLT3-mutated leukemia via targeting PLK1 signaling. Chen M, Shen C, Chen Y, Chen Z, Zhou K, Chen Y, Li W, Zeng C, Qing Y, Wu D, Xu C, Tang T, Che Y, Qin X, Xu Z, Wang K, Leung K, Sau L, Deng X, Hu J, Wu Y, Chen J. Cell Rep Med. 2024 Jul 16;5(7):101645. doi: 10.1016/j.xcrm.2024.101645. PubMed |
| In vivo single-cell CRISPR uncovers distinct TNF programmes in tumour evolution. Renz PF, Ghoshdastider U, Baghai Sain S, Valdivia-Francia F, Khandekar A, Ormiston M, Bernasconi M, Dure C, Kretz JA, Lee M, Hyams K, Forny M, Pohly M, Ficht X, Ellis SJ, Moor AE, Sendoel A. Nature. 2024 Aug;632(8024):419-428. doi: 10.1038/s41586-024-07663-y. Epub 2024 Jul 17. PubMed |
| The TDP-43/TP63 Positive Feedback Circuit Promotes Esophageal Squamous Cell Carcinoma Progression. Li W, Yang Y, Huang L, Yu X, Wang T, Zhang N, Yang M. Adv Sci (Weinh). 2024 Sep;11(35):e2402913. doi: 10.1002/advs.202402913. Epub 2024 Jul 18. PubMed |
| Unveiling the oncogenic role of LZTS1 in colorectal cancer. Xu Y, Pepe D, Yao S, Boudhan L, Verbandt S, Pu T, Creemers JWM, Liu M, Tejpar S, He Z, Zhu J, Wang Y. J Cell Mol Med. 2024 Jul;28(14):e18441. doi: 10.1111/jcmm.18441. PubMed |
| ATAD1 prevents clogging of TOM and damage caused by un-imported mitochondrial proteins. Kim J, Goldstein M, Zecchel L, Ghorayeb R, Maxwell CA, Weidberg H. Cell Rep. 2024 Aug 27;43(8):114473. doi: 10.1016/j.celrep.2024.114473. Epub 2024 Jul 17. PubMed |
| The splicing factor CCAR1 regulates the Fanconi anemia/BRCA pathway. Harada N, Asada S, Jiang L, Nguyen H, Moreau L, Marina RJ, Adelman K, Iyer DR, D'Andrea AD. Mol Cell. 2024 Jul 25;84(14):2618-2633.e10. doi: 10.1016/j.molcel.2024.06.031. Epub 2024 Jul 17. PubMed |
| Combined inhibition of KRAS(G12C) and mTORC1 kinase is synergistic in non-small cell lung cancer. Kitai H, Choi PH, Yang YC, Boyer JA, Whaley A, Pancholi P, Thant C, Reiter J, Chen K, Markov V, Taniguchi H, Yamaguchi R, Ebi H, Evans J, Jiang J, Lee B, Wildes D, de Stanchina E, Smith JAM, Singh M, Rosen N. Nat Commun. 2024 Jul 19;15(1):6076. doi: 10.1038/s41467-024-50063-z. PubMed |
| Nup358 restricts ER-mitochondria connectivity by modulating mTORC2/Akt/GSK3beta signalling. Kalarikkal M, Saikia R, Oliveira L, Bhorkar Y, Lonare A, Varshney P, Dhamale P, Majumdar A, Joseph J. EMBO Rep. 2024 Oct;25(10):4226-4251. doi: 10.1038/s44319-024-00204-8. Epub 2024 Jul 18. PubMed |
| Efficient Genome Editing with Chimeric Oligonucleotide-Directed Editing. Nguyen LT, Rakestraw NR, Pizzano BLM, Young CB, Huang Y, Beerensson KT, Fang A, Antal SG, Anamisis KV, Peggs CMD, Yan J, Jing Y, Burdine RD, Adamson B, Toettcher JE, Myhrvold C, Jain PK. bioRxiv [Preprint]. 2024 Jul 10:2024.07.09.602710. doi: 10.1101/2024.07.09.602710. PubMed |
| Tau phosphorylation suppresses oxidative stress-induced mitophagy via FKBP8 receptor modulation. Isei MO, Crockett M, Chen E, Rodwell-Bullock J, Caroll T, Girardi PA, Nehrke K, Johnson GV. bioRxiv [Preprint]. 2024 Jul 9:2024.07.05.602170. doi: 10.1101/2024.07.05.602170. PubMed |
| Protocol for transducing human primary epithelial prostate cells and patient-derived organoids with high efficiency. Jobin C, Harvey M, Lacouture A, Weidmann C, Neveu B, Pouliot F, Audet-Walsh E. STAR Protoc. 2024 Sep 20;5(3):103200. doi: 10.1016/j.xpro.2024.103200. Epub 2024 Jul 18. PubMed |
| Host cell CRISPR genomics and modelling reveal shared metabolic vulnerabilities in the intracellular development of Plasmodium falciparum and related hemoparasites. Maurizio M, Masid M, Woods K, Caldelari R, Doench JG, Naguleswaran A, Joly D, Gonzalez-Fernandez M, Zemp J, Borteele M, Hatzimanikatis V, Heussler V, Rottenberg S, Olias P. Nat Commun. 2024 Jul 21;15(1):6145. doi: 10.1038/s41467-024-50405-x. PubMed |
| Molecular insights into degron recognition by CRL5(ASB7) ubiquitin ligase. Zhou M, Wang X, Li J, Ma J, Bao Z, Yan X, Zhang B, Liu T, Yu Y, Mi W, Dong C. Nat Commun. 2024 Jul 22;15(1):6177. doi: 10.1038/s41467-024-50556-x. PubMed |
| Targeting monocytic Occludin impairs transendothelial migration and HIV neuroinvasion. Brychka D, Ayala-Nunez NV, Dupas A, Bare Y, Partiot E, Mittelheisser V, Lucansky V, Goetz JG, Osmani N, Gaudin R. EMBO Rep. 2024 Aug;25(8):3276-3299. doi: 10.1038/s44319-024-00190-x. Epub 2024 Jul 22. PubMed |
| Evaluation of DNA minicircles for delivery of adenine and cytosine base editors using activatable gene on "GO" reporter imaging systems. Evans MM, Liu S, Krautner JS, Seguin CG, Leung R, Ronald JA. Mol Ther Nucleic Acids. 2024 Jun 10;35(3):102248. doi: 10.1016/j.omtn.2024.102248. eCollection 2024 Sep 10. PubMed |
| The molecular basis underlying T cell specificity towards citrullinated epitopes presented by HLA-DR4. Loh TJ, Lim JJ, Jones CM, Dao HT, Tran MT, Baker DG, La Gruta NL, Reid HH, Rossjohn J. Nat Commun. 2024 Jul 23;15(1):6201. doi: 10.1038/s41467-024-50511-w. PubMed |
| Targeting RBM39 through indisulam induced mis-splicing of mRNA to exert anti-cancer effects in T-cell acute lymphoblastic leukemia. Ji T, Yang Y, Yu J, Yin H, Chu X, Yang P, Xu L, Wang X, Hu S, Li Y, Wu X, Liu W, Zhou B, Wang W, Zhang S, Cheng W, Chen Y, Shi L, Li Z, Zhuo R, Zhang Y, Tao Y, Wu D, Li X, Zhang Z, Fan JJ, Pan J, Lu J. J Exp Clin Cancer Res. 2024 Jul 24;43(1):205. doi: 10.1186/s13046-024-03130-8. PubMed |
| LACTB suppresses liver cancer progression through regulation of ferroptosis. Zeng K, Huang N, Liu N, Deng X, Mu Y, Zhang X, Zhang J, Zhang C, Li Y, Li Z. Redox Biol. 2024 Sep;75:103270. doi: 10.1016/j.redox.2024.103270. Epub 2024 Jul 18. PubMed |
| MTGR1 is required to maintain small intestinal stem cell populations. Short SP, Brown RE, Chen Z, Pilat JM, McElligott BA, Meenderink LM, Bickart AC, Blunt KM, Jacobse J, Wang J, Simmons AJ, Xu Y, Yang Y, Parang B, Choksi YA, Goettel JA, Lau KS, Hiebert SW, Williams CS. Cell Death Differ. 2024 Sep;31(9):1170-1183. doi: 10.1038/s41418-024-01346-x. Epub 2024 Jul 25. PubMed |
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| Helicobacter pylori-Induced Decrease in Membrane Expression of Na,K-ATPase Leads to Gastric Injury. Vagin O, Tokhtaeva E, Larauche M, Davood J, Marcus EA. Biomolecules. 2024 Jun 28;14(7):772. doi: 10.3390/biom14070772. PubMed |
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| GDNF/GFRA1 signaling contributes to chemo- and radioresistance in glioblastoma. Avenel ICN, Ewald JD, Ariey-Bonnet J, Kristensen IH, Petterson SA, Thesbjerg MN, Burton M, Thomassen M, Wennerberg K, Michaelsen SR, Kristensen BW. Sci Rep. 2024 Jul 31;14(1):17639. doi: 10.1038/s41598-024-68626-x. PubMed |
| Inhibition of BCAT1-mediated cytosolic leucine metabolism regulates Th17 responses via the mTORC1-HIF1alpha pathway. Kang YJ, Song W, Lee SJ, Choi SA, Chae S, Yoon BR, Kim HY, Lee JH, Kim C, Cho JY, Kim HJ, Lee WW. Exp Mol Med. 2024 Aug;56(8):1776-1790. doi: 10.1038/s12276-024-01286-z. Epub 2024 Aug 1. PubMed |
| CRISPR perfect adaptation for robust control of cellular immune and apoptotic responses. Zhang Y, Zhang S. Nucleic Acids Res. 2024 Sep 9;52(16):10005-10016. doi: 10.1093/nar/gkae665. PubMed |
| Protocol for the application of single-cell damage in murine intestinal organoid models. Seidler AE, Donath S, Gentemann L, Buettner M, Heisterkamp A, Kalies S. STAR Protoc. 2024 Sep 20;5(3):103153. doi: 10.1016/j.xpro.2024.103153. Epub 2024 Jul 30. PubMed |
| The BET PROTAC inhibitor GNE-987 displays anti-tumor effects by targeting super-enhancers regulated gene in osteosarcoma. Wu D, Yin H, Yang C, Zhang Z, Fang F, Wang J, Li X, Xie Y, Hu X, Zhuo R, Chen Y, Yu J, Li T, Li G, Pan J. BMC Cancer. 2024 Aug 1;24(1):928. doi: 10.1186/s12885-024-12691-y. PubMed |
| Tumor-derived GLI1 promotes remodeling of the immune tumor microenvironment in melanoma. Giammona A, De Vellis C, Crivaro E, Maresca L, Amoriello R, Ricci F, Anichini G, Pietrobono S, Pease DR, Fernandez-Zapico ME, Ballerini C, Stecca B. J Exp Clin Cancer Res. 2024 Aug 2;43(1):214. doi: 10.1186/s13046-024-03138-0. PubMed |
| A platform to deliver single and bi-specific Cas9/guide RNA to perturb genes in vitro and in vivo. Li YJ, Chien SH, Huang R, Herrmann A, Zhao Q, Li PC, Zhang C, Martincuks A, Santiago NL, Zong K, Swiderski P, Okimoto RA, Song M, Rodriguez L, Forman SJ, Wang X, Yu H. Mol Ther. 2024 Oct 2;32(10):3629-3649. doi: 10.1016/j.ymthe.2024.07.025. Epub 2024 Jul 31. PubMed |
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| A spectrum of clinically-identified cysteine mutations in fibulin-3 (EFEMP1) highlight its disulfide bonding complexity and potential to induce stress response activation. Collier GE, Hulleman JD. bioRxiv [Preprint]. 2024 Jul 23:2024.07.22.604634. doi: 10.1101/2024.07.22.604634. PubMed |
| Peptidylarginine deiminase 3 modulates response to neratinib in HER2 positive breast cancer. Romero-Perez I, Diaz-Rodriguez E, Sanchez-Diaz L, Montero JC, Pandiella A. Oncogenesis. 2024 Aug 4;13(1):30. doi: 10.1038/s41389-024-00531-4. PubMed |
| Targeting fatty acid oxidation enhances response to HER2-targeted therapy. Nandi I, Ji L, Smith HW, Avizonis D, Papavasiliou V, Lavoie C, Pacis A, Attalla S, Sanguin-Gendreau V, Muller WJ. Nat Commun. 2024 Aug 3;15(1):6587. doi: 10.1038/s41467-024-50998-3. PubMed |
| TERT upstream promoter methylation regulates TERT expression and acts as a therapeutic target in TERT promoter mutation-negative thyroid cancer. Li S, Hu G, Chen Y, Sang Y, Tang Q, Liu R. Cancer Cell Int. 2024 Aug 3;24(1):271. doi: 10.1186/s12935-024-03459-2. PubMed |
Purinosomes spatially co-localize with mitochondrial transporters.
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| Construction of an IFNAR1 knockout MDBK cell line using CRISPR/Cas9 and its effect on bovine virus replication. Geng Y, Jiang C, Yang H, Xia Q, Xu X, Yang K, Yuan X, Chen J, Chen Y, Chen X, Zhang L, Hu C, Guo A. Front Immunol. 2024 Jul 19;15:1404649. doi: 10.3389/fimmu.2024.1404649. eCollection 2024. PubMed |
| Single-cell sensor analyses reveal signaling programs enabling Ras-G12C drug resistance. Zhang JZ, Ong SE, Baker D, Maly DJ. Nat Chem Biol. 2025 Jan;21(1):47-58. doi: 10.1038/s41589-024-01684-4. Epub 2024 Aug 5. PubMed |
| Repurposing NAMPT Inhibitors for Germinal Center B Cell-Like Diffuse Large B-Cell Lymphoma. Scuoppo C, Cai B, Ofori K, Scholze H, Kumar R, D'Alessandro A, Basso K, Pasqualucci L, Dalla-Favera R. Blood Cancer Discov. 2024 Nov 1;5(6):417-427. doi: 10.1158/2643-3230.BCD-24-0020. PubMed |
| Colchicine-mediated selective autophagic degradation of HBV core proteins inhibits HBV replication and HBV-related hepatocellular carcinoma progression. Zhang H, Su X, Gu L, Tan M, Liu Y, Xu K, Ren J, Chen J, Li Z, Cheng S. Cell Death Discov. 2024 Aug 6;10(1):352. doi: 10.1038/s41420-024-02122-z. PubMed |
Programmable protein stabilization with language model-derived peptide guides.
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| Actin networks modulate heterogeneous NF-kappaB dynamics in response to TNFalpha. Butera F, Sero JE, Dent LG, Bakal C. Elife. 2024 Aug 7;13:e86042. doi: 10.7554/eLife.86042. PubMed |
| SYNGAP1 deficiency disrupts synaptic neoteny in xenotransplanted human cortical neurons in vivo. Vermaercke B, Iwata R, Wierda K, Boubakar L, Rodriguez P, Ditkowska M, Bonin V, Vanderhaeghen P. Neuron. 2024 Sep 25;112(18):3058-3068.e8. doi: 10.1016/j.neuron.2024.07.007. Epub 2024 Aug 6. PubMed |
| EphA3-targeted chimeric antigen receptor T cells are effective in glioma and generate curative memory T cell responses. Lertsumitkul L, Iliopoulos M, Wang SS, McArthur SJ, Ebert LM, Davenport AJ, Endersby R, Hansford JR, Drummond KJ, Cross R, Jenkins MR. J Immunother Cancer. 2024 Aug 7;12(8):e009486. doi: 10.1136/jitc-2024-009486. PubMed |
| Exome-wide association study identifies KDELR3 mutations in extreme myopia. Yuan J, Zhuang YY, Liu X, Zhang Y, Li K, Chen ZJ, Li D, Chen H, Liang J, Yao Y, Yu X, Zhuo R, Zhao F, Zhou X, Yu X, Qu J, Su J. Nat Commun. 2024 Aug 7;15(1):6703. doi: 10.1038/s41467-024-50580-x. PubMed |
| Molecular mimicry in multisystem inflammatory syndrome in children. Bodansky A, Mettelman RC, Sabatino JJ Jr, Vazquez SE, Chou J, Novak T, Moffitt KL, Miller HS, Kung AF, Rackaityte E, Zamecnik CR, Rajan JV, Kortbawi H, Mandel-Brehm C, Mitchell A, Wang CY, Saxena A, Zorn K, Yu DJL, Pogorelyy MV, Awad W, Kirk AM, Asaki J, Pluvinage JV, Wilson MR, Zambrano LD, Campbell AP, Thomas PG, Randolph AG, Anderson MS, DeRisi JL. Nature. 2024 Aug;632(8025):622-629. doi: 10.1038/s41586-024-07722-4. Epub 2024 Aug 7. PubMed |
| GSK3 inhibition reduces ECM production and prevents age-related macular degeneration-like pathology. DiCesare SM, Ortega AJ, Collier GE, Daniel S, Thompson KN, McCoy MK, Posner BA, Hulleman JD. JCI Insight. 2024 Aug 8;9(15):e178050. doi: 10.1172/jci.insight.178050. PubMed |
| FDA-approved disulfiram inhibits the NLRP3 inflammasome by regulating NLRP3 palmitoylation. Xu J, Pickard JM, Nunez G. Cell Rep. 2024 Aug 27;43(8):114609. doi: 10.1016/j.celrep.2024.114609. Epub 2024 Aug 7. PubMed |
| TDP-43 dysfunction leads to bioenergetic failure and lipid metabolic rewiring in human cells. Ceron-Codorniu M, Torres P, Fernandez-Bernal A, Rico-Rios S, Serrano JC, Miralles MP, Beltran M, Garcera A, Soler RM, Pamplona R, Portero-Otin M. Redox Biol. 2024 Sep;75:103301. doi: 10.1016/j.redox.2024.103301. Epub 2024 Aug 5. PubMed |
| Sugar-mediated non-canonical ubiquitination impairs Nrf1/NFE2L1 activation. Yoshida Y, Takahashi T, Ishii N, Matsuo I, Takahashi S, Inoue H, Endo A, Tsuchiya H, Okada M, Ando C, Suzuki T, Dohmae N, Saeki Y, Tanaka K, Suzuki T. Mol Cell. 2024 Aug 22;84(16):3115-3127.e11. doi: 10.1016/j.molcel.2024.07.013. Epub 2024 Aug 7. PubMed |
| Histone-methyltransferase KMT2D deficiency impairs the Fanconi anemia/BRCA pathway upon glycolytic inhibition in squamous cell carcinoma. Liu W, Cao H, Wang J, Elmusrati A, Han B, Chen W, Zhou P, Li X, Keysar S, Jimeno A, Wang CY. Nat Commun. 2024 Aug 8;15(1):6755. doi: 10.1038/s41467-024-50861-5. PubMed |
| Circular RNAs regulate neuron size and migration of midbrain dopamine neurons during development. Rybiczka-Tesulov M, Garritsen O, Veno MT, Wieg L, Dijk RV, Rahimi K, Gomes-Duarte A, Wit M, van de Haar LL, Michels L, van Kronenburg NCH, van der Meer C, Kjems J, Vangoor VR, Pasterkamp RJ. Nat Commun. 2024 Aug 8;15(1):6773. doi: 10.1038/s41467-024-51041-1. PubMed |
| The divergent effects of G3BP orthologs on human stress granule assembly imply a centric role for the core protein interaction network. Yao Z, Liu Y, Chen Q, Chen X, Zhu Z, Song S, Ma X, Yang P. Cell Rep. 2024 Aug 27;43(8):114617. doi: 10.1016/j.celrep.2024.114617. Epub 2024 Aug 8. PubMed |
| Enhancing homology-directed repair efficiency with HDR-boosting modular ssDNA donor. Jin YY, Zhang P, Liu LL, Zhao X, Hu XQ, Liu SZ, Li ZK, Liu Q, Wang JQ, Hao DL, Zhang ZQ, Chen HZ, Liu DP. Nat Commun. 2024 Aug 10;15(1):6843. doi: 10.1038/s41467-024-50788-x. PubMed |
Proximity analysis of native proteomes reveals phenotypic modifiers in a mouse model of autism and related neurodevelopmental conditions.
Gao Y, Shonai D, Trn M, Zhao J, Soderblom EJ, Garcia-Moreno SA, Gersbach CA, Wetsel WC, Dawson G, Velmeshev D, Jiang YH, Sloofman LG, Buxbaum JD, Soderling SH.
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| Human RNA Polymerase II Segregates from Genes and Nascent RNA and Transcribes in the Presence of DNA-Bound dCas9. Pessoa J, Carvalho C. Int J Mol Sci. 2024 Aug 1;25(15):8411. doi: 10.3390/ijms25158411. PubMed |
| CHD4 R975H mutant activates tumorigenic pathways and promotes stemness and M2-like macrophage polarization in endometrial cancer. Zhang Q, Zhu F, Tong Y, Shi D, Zhang J. Sci Rep. 2024 Aug 10;14(1):18617. doi: 10.1038/s41598-024-69233-6. PubMed |
| CD177 is a novel IgG Fc receptor and CD177 genetic variants affect IgG-mediated function. Li Y, Wu J. Front Immunol. 2024 Jul 26;15:1418539. doi: 10.3389/fimmu.2024.1418539. eCollection 2024. PubMed |
| The Ribosome Assembly Factor LSG1 Interacts with Vesicle-Associated Membrane Protein-Associated Proteins (VAPs). Sutjita P, Musalgaonkar S, Recchia-Rife J, Huang L, Xhemalce B, Johnson AW. Mol Cell Biol. 2024;44(9):345-357. doi: 10.1080/10985549.2024.2384600. Epub 2024 Aug 12. PubMed |
| Protocol for establishing inducible CRISPRd system for blocking transcription factor-binding sites in human pluripotent stem cells. Matsui S, Shiley JR, Buckley M, Lim HW, Hu YC, Mayhew CN, Iwafuchi M. STAR Protoc. 2024 Sep 20;5(3):103233. doi: 10.1016/j.xpro.2024.103233. Epub 2024 Aug 11. PubMed |
| Preclinical spheroid models identify BMX as a therapeutic target for metastatic MYCN nonamplified neuroblastoma. Sundaramoorthy S, Colombo DF, Sanalkumar R, Broye L, Balmas Bourloud K, Boulay G, Cironi L, Stamenkovic I, Renella R, Kuttler F, Turcatti G, Rivera MN, Muhlethaler-Mottet A, Bardet AF, Riggi N. JCI Insight. 2024 Jul 22;9(14):e169647. doi: 10.1172/jci.insight.169647. PubMed |
| Strong capacity of differentiated PD-L1 CAR-modified UCB-CD34(+) cells and PD-L1 CAR-modified UCB-CD34(+)-derived NK cells in killing target cells and restoration of the anti-tumor function of PD-1-high exhausted T Cells. Ghaedrahmati F, Akbari V, Seyedhosseini-Ghaheh H, Esmaeil N. Stem Cell Res Ther. 2024 Aug 13;15(1):257. doi: 10.1186/s13287-024-03871-5. PubMed |
| A potential therapeutic strategy based on acute oxidative stress induction for wild-type NRF2/KEAP1 lung squamous cell carcinoma. Sanchez-Ortega M, Garrido A, Cirauqui C, Sanz-Gonzalez L, Hernandez MC, Gonzalez-Garcia A, Obregon K, Ferrer I, Paz-Ares L, Carrera AC. Redox Biol. 2024 Sep;75:103305. doi: 10.1016/j.redox.2024.103305. Epub 2024 Aug 8. PubMed |
Prior Fc receptor activation primes macrophages for increased sensitivity to IgG via long-term and short-term mechanisms.
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Dev Cell. 2024 Aug 9:S1534-5807(24)00457-X. doi: 10.1016/j.devcel.2024.07.017.
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| SARS-CoV-2 N protein-induced Dicer, XPO5, SRSF3, and hnRNPA3 downregulation causes pneumonia. Luo YW, Zhou JP, Ji H, Xu D, Zheng A, Wang X, Dai Z, Luo Z, Cao F, Wang XY, Bai Y, Chen D, Chen Y, Wang Q, Yang Y, Zhang X, Chiu S, Peng X, Huang AL, Tang KF. Nat Commun. 2024 Aug 13;15(1):6964. doi: 10.1038/s41467-024-51192-1. PubMed |
| Primate-specific BTN3A2 protects against SARS-CoV-2 infection by interacting with and reducing ACE2. Xu L, Yu D, Xu M, Liu Y, Yang LX, Zou QC, Feng XL, Li MH, Sheng N, Yao YG. EBioMedicine. 2024 Sep;107:105281. doi: 10.1016/j.ebiom.2024.105281. Epub 2024 Aug 13. PubMed |
| OPA1 promotes ferroptosis by augmenting mitochondrial ROS and suppressing an integrated stress response. Liang FG, Zandkarimi F, Lee J, Axelrod JL, Pekson R, Yoon Y, Stockwell BR, Kitsis RN. Mol Cell. 2024 Aug 22;84(16):3098-3114.e6. doi: 10.1016/j.molcel.2024.07.020. Epub 2024 Aug 13. PubMed |
| HLTF resolves G4s and promotes G4-induced replication fork slowing to maintain genome stability. Bai G, Endres T, Kuhbacher U, Mengoli V, Greer BH, Peacock EM, Newton MD, Stanage T, Dello Stritto MR, Lungu R, Crossley MP, Sathirachinda A, Cortez D, Boulton SJ, Cejka P, Eichman BF, Cimprich KA. Mol Cell. 2024 Aug 22;84(16):3044-3060.e11. doi: 10.1016/j.molcel.2024.07.018. Epub 2024 Aug 13. PubMed |
| Generation of a conditional cellular senescence model using proximal tubule cells and fibroblasts from human kidneys. Shao X, Xu H, Kim H, Ljaz S, Beier F, Jankowski V, Lellig M, Vankann L, Werner JN, Chen L, Ziegler S, Kuppe C, Zenke M, Schneider RK, Hayat S, Saritas T, Kramann R. Cell Death Discov. 2024 Aug 14;10(1):364. doi: 10.1038/s41420-024-02131-y. PubMed |
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| The epithelial Na(+) channel (ENaC) in ovarian granulosa cells modulates Ca(2+) mobilization and gonadotrophin signaling for estrogen homeostasis and female fertility. Ma X, Xu R, Chen J, Wang S, Hu P, Wu Y, Que Y, Du W, Cai X, Chen H, Guo J, Li TC, Ruan YC. Cell Commun Signal. 2024 Aug 14;22(1):398. doi: 10.1186/s12964-024-01778-5. PubMed |
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| Influenza vaccination stimulates maturation of the human T follicular helper cell response. Schattgen SA, Turner JS, Ghonim MA, Crawford JC, Schmitz AJ, Kim H, Zhou JQ, Awad W, Mettelman RC, Kim W, McIntire KM, Haile A, Klebert MK, Suessen T, Middleton WD, Teefey SA, Presti RM, Ellebedy AH, Thomas PG. Nat Immunol. 2024 Sep;25(9):1742-1753. doi: 10.1038/s41590-024-01926-6. Epub 2024 Aug 20. PubMed |
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| EZH2 represses mesenchymal genes and upholds the epithelial state of breast carcinoma cells. Gallardo A, Lopez-Onieva L, Belmonte-Reche E, Fernandez-Rengel I, Serrano-Prados A, Molina A, Sanchez-Pozo A, Landeira D. Cell Death Dis. 2024 Aug 22;15(8):609. doi: 10.1038/s41419-024-07011-y. PubMed |
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Associated Plasmids |
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| Suppression of non-muscle myosin II boosts T cell cytotoxicity against tumors. Yang Y, Wen D, Lin F, Song X, Pang R, Sun W, Yu D, Zhang Z, Yu T, Kong J, Zhang L, Cao X, Liao W, Wang D, Yang Q, Liang J, Zhang N, Li K, Xiong C, Liu Y. Sci Adv. 2024 Nov;10(44):eadp0631. doi: 10.1126/sciadv.adp0631. Epub 2024 Nov 1. PubMed |
| Selective degradation of multimeric proteins by TRIM21-based molecular glue and PROTAC degraders. Lu P, Cheng Y, Xue L, Ren X, Xu X, Chen C, Cao L, Li J, Wu Q, Sun S, Hou J, Jia W, Wang W, Ma Y, Jiang Z, Li C, Qi X, Huang N, Han T. Cell. 2024 Dec 12;187(25):7126-7142.e20. doi: 10.1016/j.cell.2024.10.015. Epub 2024 Nov 1. PubMed |
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| Type III interferons induce pyroptosis in gut epithelial cells and impair mucosal repair. Jena KK, Mambu J, Boehmer D, Sposito B, Millet V, de Sousa Casal J, Muendlein HI, Spreafico R, Fenouil R, Spinelli L, Wurbel S, Riquier C, Galland F, Naquet P, Chasson L, Elkins M, Mitsialis V, Ketelut-Carneiro N, Bugda Gwilt K, Thiagarajah JR, Ruan HB, Lin Z, Lien E, Shao F, Chou J, Poltorak A, Ordovas-Montanes J, Fitzgerald KA, Snapper SB, Broggi A, Zanoni I. Cell. 2024 Dec 26;187(26):7533-7550.e23. doi: 10.1016/j.cell.2024.10.010. Epub 2024 Nov 4. PubMed |
| Multimodal targeting chimeras enable integrated immunotherapy leveraging tumor-immune microenvironment. Lin F, Yin S, Zhang Z, Yu Y, Fang H, Liang Z, Zhu R, Zhou H, Li J, Cao K, Guo W, Qin S, Zhang Y, Lu C, Li H, Liu S, Zhang H, Ye B, Lin J, Li Y, Kang X, Xi JJ, Chen PR. Cell. 2024 Dec 26;187(26):7470-7491.e32. doi: 10.1016/j.cell.2024.10.016. Epub 2024 Nov 5. PubMed |
Rapid parallel reconstruction and specificity screening of hundreds of T cell receptors.
Afeyan AB, Wu CJ, Oliveira G.
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| Nuclear receptor E75/NR1D2 promotes tumor malignant transformation by integrating Hippo and Notch pathways. Wang X, Guo Y, Lin P, Yu M, Song S, Xu W, Kong D, Wang Y, Zhang Y, Lu F, Xie Q, Ma X. EMBO J. 2024 Dec;43(24):6336-6363. doi: 10.1038/s44318-024-00290-3. Epub 2024 Nov 8. PubMed |
| A platform of functional studies of ESCC-associated gene mutations identifies the roles of TGFBR2 in ESCC progression and metastasis. Wang J, Du J, Luo X, Guo L, Liu Y, Zhou J, Zou Y, Lu Z, Pan X, Chen X, Zhong A, Wan X, Wang L, Liu H, Dai S, Zhang S, Xiong X, Tan P, Wang M, Wu B, Zhang Q, Wang Y, Zhang M, Lu R, Lin H, Li Y, Li Y, Han Z, Chen L, Hu B, Liu Y, Na F, Chen C. Cell Rep. 2024 Nov 26;43(11):114952. doi: 10.1016/j.celrep.2024.114952. Epub 2024 Nov 10. PubMed |
Transcriptome-scale RNA-targeting CRISPR screens reveal essential lncRNAs in human cells.
Liang WW, Muller S, Hart SK, Wessels HH, Mendez-Mancilla A, Sookdeo A, Choi O, Caragine CM, Corman A, Lu L, Kolumba O, Williams B, Sanjana NE.
Cell. 2024 Dec 26;187(26):7637-7654.e29. doi: 10.1016/j.cell.2024.10.021. Epub 2024 Nov 11.
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| ARF alters PAF1 complex integrity to selectively repress oncogenic transcription programs upon p53 loss. Wang J, Fendler NL, Shukla A, Wu SY, Challa A, Lee J, Joachimiak LA, Minna JD, Chiang CM, Vos SM, D'Orso I. Mol Cell. 2024 Dec 5;84(23):4538-4557.e12. doi: 10.1016/j.molcel.2024.10.020. Epub 2024 Nov 11. PubMed |
| Altered sphingolipid biosynthetic flux and lipoprotein trafficking contribute to trans-fat-induced atherosclerosis. Gengatharan JM, Handzlik MK, Chih ZY, Ruchhoeft ML, Secrest P, Ashley EL, Green CR, Wallace M, Gordts PLSM, Metallo CM. Cell Metab. 2025 Jan 7;37(1):274-290.e9. doi: 10.1016/j.cmet.2024.10.016. Epub 2024 Nov 14. PubMed |
| Targeting the aminopeptidase ERAP enhances antitumor immunity by disrupting the NKG2A-HLA-E inhibitory checkpoint. Tsao HW, Anderson S, Finn KJ, Perera JJ, Pass LF, Schneider EM, Jiang A, Fetterman R, Chuong CL, Kozuma K, Stickler MM, Creixell M, Klaeger S, Phulphagar KM, Rachimi S, Verzani EK, Olsson N, Dubrot J, Pech MF, Silkworth W, Lane-Reticker SK, Allen PM, Ibrahim K, Knudsen NH, Cheng AY, Long AH, Ebrahimi-Nik H, Kim SY, Du PP, Iracheta-Vellve A, Robitschek EJ, Suermondt JSMT, Davis TGR, Wolfe CH, Atluri T, Olander KE, Rush JS, Sundberg TB, McAllister FE, Abelin JG, Firestone A, Stokoe D, Carr SA, Harding FA, Yates KB, Manguso RT. Immunity. 2024 Dec 10;57(12):2863-2878.e12. doi: 10.1016/j.immuni.2024.10.013. Epub 2024 Nov 18. PubMed |
| Human genetics identify convergent signals in mitochondrial LACTB-mediated lipid metabolism in cardiovascular-kidney-metabolic syndrome. Li S, Liu H, Hu H, Ha E, Prasad P, Jenkins BC, Das US, Mukherjee S, Shishikura K, Hu R, Rader DJ, Pei L, Baur JA, Matthews ML, FitzGerald GA, McReynolds MR, Susztak K. Cell Metab. 2025 Jan 7;37(1):154-168.e7. doi: 10.1016/j.cmet.2024.10.007. Epub 2024 Nov 18. PubMed |
| Host specific sphingomyelin is critical for replication of diverse RNA viruses. Han S, Ye X, Yang J, Peng X, Jiang X, Li J, Zheng X, Zhang X, Zhang Y, Zhang L, Wang W, Li J, Xin W, Zhang X, Xiao G, Peng K, Zhang L, Du X, Zhou L, Liu W, Li H. Cell Chem Biol. 2024 Dec 19;31(12):2052-2068.e11. doi: 10.1016/j.chembiol.2024.10.009. Epub 2024 Nov 19. PubMed |
| Gliocidin is a nicotinamide-mimetic prodrug that targets glioblastoma. Chen YJ, Iyer SV, Hsieh DC, Li B, Elias HK, Wang T, Li J, Ganbold M, Lien MC, Peng YC, Xie XP, Jayewickreme CD, van den Brink MRM, Brady SF, Lim SK, Parada LF. Nature. 2024 Dec;636(8042):466-473. doi: 10.1038/s41586-024-08224-z. Epub 2024 Nov 20. PubMed |
| Cancer cells restrict immunogenicity of retrotransposon expression via distinct mechanisms. Sun S, You E, Hong J, Hoyos D, Del Priore I, Tsanov KM, Mattagajasingh O, Di Gioacchino A, Marhon SA, Chacon-Barahona J, Li H, Jiang H, Hozeifi S, Rosas-Bringas O, Xu KH, Song Y, Lang ER, Rojas AS, Nieman LT, Patel BK, Murali R, Chanda P, Karacay A, Vabret N, De Carvalho DD, Zenklusen D, LaCava J, Lowe SW, Ting DT, Iacobuzio-Donahue CA, Solovyov A, Greenbaum BD. Immunity. 2024 Dec 10;57(12):2879-2894.e11. doi: 10.1016/j.immuni.2024.10.015. Epub 2024 Nov 21. PubMed |
Interleukin-1alpha release during necrotic-like cell death generates myeloid-driven immunosuppression that restricts anti-tumor immunity.
Hanggi K, Li J, Gangadharan A, Liu X, Celias DP, Osunmakinde O, Keske A, Davis J, Ahmad F, Giron A, Anadon CM, Gardner A, DeNardo DG, Shaw TI, Beg AA, Yu X, Ruffell B.
Cancer Cell. 2024 Nov 13:S1535-6108(24)00402-1. doi: 10.1016/j.ccell.2024.10.014.
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| Hyperthermic Intrathoracic Chemotherapy Modulates the Immune Microenvironment of Pleural Mesothelioma and Improves the Impact of Dual Immune Checkpoint Inhibition. Hao Y, Gkasti A, Managh AJ, Dagher J, Sifis A, Tiron L, Chriqui LE, Marie DN, De Souza Silva O, Christodoulou M, Peters S, Joyce JA, Krueger T, Gonzalez M, Abdelnour-Berchtold E, Sempoux C, Clerc D, Teixeira-Farinha H, Hubner M, Meylan E, Dyson PJ, Cavin S, Perentes JY. Cancer Immunol Res. 2025 Feb 3;13(2):185-199. doi: 10.1158/2326-6066.CIR-24-0245. PubMed |
| Inceptor binds to and directs insulin towards lysosomal degradation in beta cells. Siehler J, Bilekova S, Chapouton P, Dema A, Albanese P, Tamara S, Jain C, Sterr M, Enos SJ, Chen C, Malhotra C, Villalba A, Schomann L, Bhattacharya S, Feng J, Akgun Canan M, Ribaudo F, Ansarullah, Burtscher I, Ahlbrecht C, Plettenburg O, Kurth T, Scharfmann R, Speier S, Scheltema RA, Lickert H. Nat Metab. 2024 Dec;6(12):2374-2390. doi: 10.1038/s42255-024-01164-y. Epub 2024 Nov 25. PubMed |
| Breast Cancer Subtype-Specific Organotropism Is Dictated by FOXF2-Regulated Metastatic Dormancy and Recovery. Jiang WJ, Zhou TH, Huang HJ, Li LS, Tan H, Zhang R, Wang QS, Feng YM. Cancer Res. 2025 Feb 17;85(4):644-659. doi: 10.1158/0008-5472.CAN-24-0479. PubMed |
| A Novel Tax-Responsive Reporter T-Cell Line to Analyze Infection of HTLV-1. Heym S, Krebs P, Ott K, Donhauser N, Kemeter LM, Simon F, Millen S, Thoma-Kress AK. Pathogens. 2024 Nov 19;13(11):1015. doi: 10.3390/pathogens13111015. PubMed |
| Blocking WNT7A Enhances MHC-I Antigen Presentation and Enhances the Effectiveness of Immune Checkpoint Blockade Therapy. Sun J, Wang P, Yi Z, Wu Y, Wei Y, Fang H, Song D, Chen Y, Du H, Huang J, Li Q, Yang D, Ren G, Li H. Cancer Immunol Res. 2025 Mar 4;13(3):400-416. doi: 10.1158/2326-6066.CIR-24-0484. PubMed |
| UHRF1 ubiquitin ligase activity supports the maintenance of low-density CpG methylation. Tiedemann RL, Hrit J, Du Q, Wiseman AK, Eden HE, Dickson BM, Kong X, Chomiak AA, Vaughan RM, Tibben BM, Hebert JM, David Y, Zhou W, Baylin SB, Jones PA, Clark SJ, Rothbart SB. Nucleic Acids Res. 2024 Dec 11;52(22):13733-13756. doi: 10.1093/nar/gkae1105. PubMed |
| Phase separation of chimeric antigen receptor promotes immunological synapse maturation and persistent cytotoxicity. Xu X, Chen H, Ren Z, Xu X, Wu W, Yang H, Wang J, Zhang Y, Zhou Q, Li H, Zhang S, Wang H, Xu C. Immunity. 2024 Dec 10;57(12):2755-2771.e8. doi: 10.1016/j.immuni.2024.11.005. Epub 2024 Nov 27. PubMed |
| Kinome-wide CRISPR-Cas9 screens revealed EXOSC10 as a positive regulator of TGF-beta signaling. Wang D, Zhang X, Guo J, Liu W, Zhou Y, Wang R. Biochem Biophys Rep. 2024 Nov 12;40:101864. doi: 10.1016/j.bbrep.2024.101864. eCollection 2024 Dec. PubMed |
| Claudin-4 Stabilizes the Genome via Nuclear and Cell-Cycle Remodeling to Support Ovarian Cancer Cell Survival. Villagomez FR, Lang J, Nunez-Avellaneda D, Behbakht K, Dimmick HL, Webb PG, Nephew KP, Neville M, Woodruff ER, Bitler BG. Cancer Res Commun. 2025 Jan 1;5(1):39-53. doi: 10.1158/2767-9764.CRC-24-0558. PubMed |
| Optimized reporters for multiplexed detection of transcription factor activity. Trauernicht M, Filipovska T, Rastogi C, van Steensel B. Cell Syst. 2024 Dec 18;15(12):1107-1122.e7. doi: 10.1016/j.cels.2024.11.003. Epub 2024 Dec 6. PubMed |
| Gain-of-Function Chromatin Remodeling Activity of Oncogenic FOXL2C134W Reprograms Glucocorticoid Receptor Occupancy to Drive Granulosa Cell Tumors. Welte T, Vuttaradhi VK, Khlebus EY, Brodsky A, Flores Legarreta A, Celestino J, Powell RT, Stephan CC, Nguyen N, Li J, Takamatsu S, Calzoncinth K, Sood AK, Gershenson DM, Futreal PA, Lawson B, Hillman RT. Cancer Res. 2025 Mar 3;85(5):875-893. doi: 10.1158/0008-5472.CAN-24-2341. PubMed |
| Fusobacterium nucleatum promotes colorectal cancer through neogenesis of tumor stem cells. Wang Q, Hu T, Zhang Q, Zhang Y, Dong X, Jin Y, Li J, Guo Y, Guo F, Chen Z, Zhong P, Yang Y, Ma Y. J Clin Invest. 2025 Feb 3;135(3):e181595. doi: 10.1172/JCI181595. PubMed |
Restricting lysine normalizes toxic catabolites associated with ALDH7A1 deficiency in cells and mice.
Johal AS, Al-Shekaili HH, Abedrabbo M, Kehinde AZ, Towriss M, Koe JC, Hewton KG, Thomson SB, Ciernia AV, Leavitt B, Parker SJ.
Cell Rep. 2024 Dec 24;43(12):115069. doi: 10.1016/j.celrep.2024.115069. Epub 2024 Dec 10.
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| Nzf2 promotes oligodendrocyte differentiation and regeneration via repressing HDAC1-mediated histone deacetylation. Xu X, Fang M, Chen L, Huang H, Dai ZM, Yang J, Qiu M. Sci Adv. 2024 Dec 13;10(50):eadf8405. doi: 10.1126/sciadv.adf8405. Epub 2024 Dec 13. PubMed |
| Inhibiting intracellular CD28 in cancer cells enhances antitumor immunity and overcomes anti-PD-1 resistance via targeting PD-L1. Yang Z, Liu X, Zhu J, Chai Y, Cong B, Li B, Gao W, Hu Y, Wen M, Liu Y, Fu L, Cao X. Cancer Cell. 2025 Jan 13;43(1):86-102.e10. doi: 10.1016/j.ccell.2024.11.008. Epub 2024 Dec 12. PubMed |
| Daily glucocorticoids promote glioblastoma growth and circadian synchrony to the host. Gonzalez-Aponte MF, Damato AR, Simon T, Aripova N, Darby F, Jeon MS, Luo J, Rubin JB, Herzog ED. Cancer Cell. 2025 Jan 13;43(1):144-160.e7. doi: 10.1016/j.ccell.2024.11.012. Epub 2024 Dec 12. PubMed |
| Commensal papillomavirus immunity preserves the homeostasis of highly mutated normal skin. Son HG, Ha DT, Xia Y, Li T, Blandin J, Oka T, Azin M, Conrad DN, Zhou C, Zeng Y, Hasegawa T, Strickley JD, Messerschmidt JL, Guennoun R, Erlich TH, Shoemaker GL, Johnson LH, Palmer KE, Fisher DE, Horn TD, Neel VA, Nazarian RM, Joh JJ, Demehri S. Cancer Cell. 2025 Jan 13;43(1):36-48.e10. doi: 10.1016/j.ccell.2024.11.013. Epub 2024 Dec 12. PubMed |
| Canonical androgen response element motifs are tumor suppressive regulatory elements in the prostate. Chen X, Augello MA, Liu D, Lin K, Hakansson A, Sjostrom M, Khani F, Deonarine LD, Liu Y, Travascio-Green J, Wu J, Chan UI, Owiredu J, Loda M, Feng FY, Robinson BD, Davicioni E, Sboner A, Barbieri CE. Nat Commun. 2024 Dec 13;15(1):10675. doi: 10.1038/s41467-024-53734-z. PubMed |
| Distinct differentiation trajectories leave lasting impacts on gene regulation and function of V2a interneurons. Elder NH, Majd A, Bulger EA, Samuel RM, Zholudeva LV, McDevitt TC, Fattahi F. bioRxiv [Preprint]. 2024 Dec 6:2024.12.03.626573. doi: 10.1101/2024.12.03.626573. PubMed |
| Control of Epithelial Tissue Organization by mRNA Localization. Mason DE, Madsen TD, Gasparski AN, Jiwnani N, Lechler T, Weigert R, Iglesias-Bartolome R, Mili S. bioRxiv [Preprint]. 2024 Dec 2:2024.12.02.626432. doi: 10.1101/2024.12.02.626432. PubMed |
| Ubiquitin Ligase ITCH Regulates Life Cycle of SARS-CoV-2 Virus. Xiang Q, Wouters C, Chang P, Lu YN, Liu M, Wang H, Yang J, Pekosz A, Zhang Y, Wang J. bioRxiv [Preprint]. 2024 Dec 5:2024.12.04.624804. doi: 10.1101/2024.12.04.624804. PubMed |
| Molecular Insights into the Regulation of GNPTAB by TMEM251. Yang X, Doray B, Venkatarangan V, Jennings BC, Henn D, Liang J, Zhao H, Zhang W, Zhang B, Yu L, Chen L, Kornfeld S, Li M. bioRxiv [Preprint]. 2024 Dec 5:2024.12.05.627003. doi: 10.1101/2024.12.05.627003. PubMed |
| Expanding GABAergic Neuronal Diversity in iPSC-Derived Disease Models. Hu R, Boshans LL, Zhu B, Cai P, Tao Y, Youssef M, Girrbach GI, Song Y, Wang X, Tsankov A, Buxbaum JD, Ma S, Yang N. bioRxiv [Preprint]. 2024 Dec 4:2024.12.03.626438. doi: 10.1101/2024.12.03.626438. PubMed |
| DNA sequence-induced solid phase transition as a solution to the genome folding paradox. Pulupa JM, McArthur NG, Stathi O, Wang M, Zazhytska M, Pirozzolo ID, Nayar A, Shapiro L, Lomvardas S. Res Sq [Preprint]. 2024 Dec 5:rs.3.rs-5448201. doi: 10.21203/rs.3.rs-5448201/v1. PubMed |
| SLMO transfers phosphatidylserine between the outer and inner mitochondrial membrane in Drosophila. Zhao S, Jiang X, Li N, Wang T. PLoS Biol. 2024 Dec 16;22(12):e3002941. doi: 10.1371/journal.pbio.3002941. eCollection 2024 Dec. PubMed |
| A High-Throughput Neurosphere-Based Colony Formation Assay to Test Drug and Radiation Sensitivity of Different Patient-Derived Glioblastoma Lines. Kumar M, Nassour-Caswell LC, Alrefai H, Anderson JC, Schanel TL, Hicks PH, Cardan R, Willey CD. Cells. 2024 Dec 3;13(23):1995. doi: 10.3390/cells13231995. PubMed |
| Broccoli Sprout Extract Suppresses Particulate-Matter-Induced Matrix-Metalloproteinase (MMP)-1 and Cyclooxygenase (COX)-2 Expression in Human Keratinocytes by Direct Targeting of p38 MAP Kinase. Yun J, Kim JE. Nutrients. 2024 Nov 30;16(23):4156. doi: 10.3390/nu16234156. PubMed |
| An Unbiased Approach to Identifying Cellular Reprogramming-Inducible Enhancers. Klagkou E, Valakos D, Foutadakis S, Polyzos A, Papadopoulou A, Vatsellas G, Thanos D. Int J Mol Sci. 2024 Dec 6;25(23):13128. doi: 10.3390/ijms252313128. PubMed |
| EV-Elute: A universal platform for the enrichment of functional surface marker-defined extracellular vesicle subpopulations. de Voogt WS, Frunt R, Leandro RM, Triesscheijn CS, Monica B, Paspali I, Tielemans M, Francois JJJM, Seinen CW, de Jong OG, Kooijmans SAA. J Extracell Vesicles. 2024 Dec;13(12):e70017. doi: 10.1002/jev2.70017. PubMed |
Principles of CRISPR-Cas13 mismatch intolerance enable selective silencing of point-mutated oncogenic RNA with single-base precision.
Shembrey C, Yang R, Casan J, Hu W, Chen H, Singh GJ, Sadras T, Prasad K, Shortt J, Johnstone RW, Trapani JA, Ekert PG, Fareh M.
Sci Adv. 2024 Dec 20;10(51):eadl0731. doi: 10.1126/sciadv.adl0731. Epub 2024 Dec 18.
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| CPNE7 promotes colorectal tumorigenesis by interacting with NONO to initiate ZFP42 transcription. Zhao L, Sun X, Hou C, Yang Y, Wang P, Xu Z, Chen Z, Zhang X, Wu G, Chen H, Xing H, Xie H, He L, Jin S, Liu B. Cell Death Dis. 2024 Dec 18;15(12):896. doi: 10.1038/s41419-024-07288-z. PubMed |
| USP39 regulates pyruvate handling in non-small cell lung cancer. Becirovic T, Zhang B, Vakifahmetoglu-Norberg H, Kaminskyy VO, Kochetkova E, Norberg E. Cell Death Discov. 2024 Dec 18;10(1):502. doi: 10.1038/s41420-024-02264-0. PubMed |
| Overexpression of ELF3 in the PTEN-deficient lung epithelium promotes lung cancer development by inhibiting ferroptosis. Yuan Z, Han X, Xiao M, Zhu T, Xu Y, Tang Q, Lian C, Wang Z, Li J, Wang B, Li C, Xiang X, Jin R, Liu Y, Yu X, Zhang K, Li S, Ray M, Li R, Gruzdev A, Shao S, Shao F, Wang H, Lian W, Tang Y, Chen D, Lei Y, Jin X, Li Q, Long W, Huang H, DeMayo FJ, Liu J. Cell Death Dis. 2024 Dec 18;15(12):897. doi: 10.1038/s41419-024-07274-5. PubMed |
| MACC1 ablation suppresses the dedifferentiation process of non-CSCs in lung cancer through stabilizing KLF4. Li Z, Wang S, Guo T, Yan X, Chen C, Zhang W, Zhao J, Zhang J, Zhao S, Wang Y, Qi Y, Gu C. Cell Death Discov. 2024 Dec 18;10(1):494. doi: 10.1038/s41420-024-02256-0. PubMed |
| Selenoprotein O Promotes Melanoma Metastasis and Regulates Mitochondrial Complex II Activity. Nascentes Melo LM, Sabatier M, Ramesh V, Szylo KJ, Fraser CS, Pon A, Mitchell EC, Servage KA, Allies G, Westedt IV, Cansiz F, Krystkiewicz J, Kutritz A, Schadendorf D, Morrison SJ, Ubellacker JM, Sreelatha A, Tasdogan A. Cancer Res. 2025 Mar 3;85(5):942-955. doi: 10.1158/0008-5472.CAN-23-2194. PubMed |
| Structural and functional alterations of neurons derived from sporadic Alzheimer's disease hiPSCs are associated with downregulation of the LIMK1-cofilin axis. Sollazzo R, Li Puma DD, Aceto G, Paciello F, Colussi C, Vita MG, Giuffre GM, Pastore F, Casamassa A, Rosati J, Novelli A, Maietta S, Tiziano FD, Marra C, Ripoli C, Grassi C. Alzheimers Res Ther. 2024 Dec 19;16(1):267. doi: 10.1186/s13195-024-01632-3. PubMed |
| Modeling vascular dynamics at the initial stage of endochondral ossification on a microfluidic chip using a human embryonic-stem-cell-derived organoid. Kesharwani A, Tani S, Nishikawa M, Sakai Y, Okada H, Ohba S, Chung UI, Hojo H. Regen Ther. 2024 Dec 4;28:90-100. doi: 10.1016/j.reth.2024.11.018. eCollection 2025 Mar. PubMed |
| Cancer mutations rewire the RNA methylation specificity of METTL3-METTL14. Zhang C, Scott RL, Tunes L, Hsieh MH, Wang P, Kumar A, Khadgi BB, Yang YY, Doxtader Lacy KA, Herrell E, Zhang X, Evers B, Wang Y, Xing C, Zhu H, Nam Y. Sci Adv. 2024 Dec 20;10(51):eads4750. doi: 10.1126/sciadv.ads4750. Epub 2024 Dec 20. PubMed |
Periodic ER-plasma membrane junctions support long-range Ca(2+) signal integration in dendrites.
Benedetti L, Fan R, Weigel AV, Moore AS, Houlihan PR, Kittisopikul M, Park G, Petruncio A, Hubbard PM, Pang S, Xu CS, Hess HF, Saalfeld S, Rangaraju V, Clapham DE, De Camilli P, Ryan TA, Lippincott-Schwartz J.
Cell. 2025 Jan 23;188(2):484-500.e22. doi: 10.1016/j.cell.2024.11.029. Epub 2024 Dec 20.
PubMed
Associated Plasmids |
| TGFbeta signaling sensitizes MEKi-resistant human melanoma to targeted therapy-induced apoptosis. Loos B, Salas-Bastos A, Nordin A, Debbache J, Stierli S, Cheng PF, Rufli S, Wyss C, Levesque MP, Dummer R, Wong WW, Pascolo S, Cantu C, Sommer L. Cell Death Dis. 2024 Dec 21;15(12):925. doi: 10.1038/s41419-024-07305-1. PubMed |
| Programming the elongation of mammalian cell aggregates with synthetic gene circuits. Courte J, Chung C, Jain N, Salazar C, Phuchane N, Grosser S, Lam C, Morsut L. bioRxiv [Preprint]. 2024 Dec 11:2024.12.11.627621. doi: 10.1101/2024.12.11.627621. PubMed |
| Nuclear Control of Mitochondrial Homeostasis and Venetoclax Efficacy in AML via COX4I1. Zhang L, Zhang H, Wang TY, Li M, Chan AKN, Kang H, Foong LC, Liu Q, Pokharel SP, Mattson NM, Singh P, Elsayed Z, Kuang B, Wang X, Rosen ST, Chen J, Yang L, Chou TF, Su R, Chen CD. Adv Sci (Weinh). 2025 Feb;12(6):e2404620. doi: 10.1002/advs.202404620. Epub 2024 Dec 23. PubMed |
| T-cadherin modulates adipogenic differentiation in mesenchymal stem cells: insights into ligand interactions. Sysoeva V, Semina E, Klimovich P, Kulebyakin K, Dzreyan V, Sotskaya E, Shchipova A, Popov V, Shilova A, Brodsky I, Khabibullin N, Voloshin N, Tkachuk V, Rubina K. Front Cell Dev Biol. 2024 Dec 9;12:1446363. doi: 10.3389/fcell.2024.1446363. eCollection 2024. PubMed |
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| HIF1alpha controls steroidogenesis under acute hypoxic stress. Ariyeloye S, Watts D, Jaykar MT, Ermis C, Kruger A, Kaden D, Stepien BK, Alexaki VI, Peitzsch M, Bechmann N, Mirtschink P, El-Armouche A, Wielockx B. Cell Commun Signal. 2025 Feb 13;23(1):86. doi: 10.1186/s12964-025-02080-8. PubMed |
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| Antisense oligonucleotide-mediated TRA2beta poison exon inclusion induces the expression of a lncRNA with anti-tumor effects. Leclair NK, Brugiolo M, Park S, Devoucoux M, Urbanski L, Angarola BL, Yurieva M, Anczukow O. Nat Commun. 2025 Feb 15;16(1):1670. doi: 10.1038/s41467-025-56913-8. PubMed |
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| PARP7 inhibits type I interferon signaling to prevent autoimmunity and lung disease. Jeltema D, Knox K, Dobbs N, Tang Z, Xing C, Araskiewicz A, Yang K, Siordia IR, Matthews J, Cohen M, Yan N. J Exp Med. 2025 May 5;222(5):e20241184. doi: 10.1084/jem.20241184. Epub 2025 Feb 19. PubMed |
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| Epigenetic priming promotes acquisition of tyrosine kinase inhibitor resistance and oncogene amplification in human lung cancer. Starble RM, Sun EG, Gbyli R, Radda J, Lu J, Jensen TB, Sun N, Khudaverdyan N, Hu B, Melnick MA, Zhao S, Roper N, Wang GG, Song J, Politi K, Wang S, Xiao AZ. bioRxiv [Preprint]. 2025 Jan 27:2025.01.26.634826. doi: 10.1101/2025.01.26.634826. PubMed |
| The SP140-RESIST pathway regulates interferon mRNA stability and antiviral immunity. Witt KC, Dziulko A, An J, Pekovic F, Cheng AX, Liu GY, Lee OV, Turner DJ, Lari A, Gaidt MM, Chavez R, Fattinger SA, Abraham P, Dhaliwal H, Lee AY, Kotov DI, Coscoy L, Glaunsinger BA, Valkov E, Chuong EB, Vance RE. bioRxiv [Preprint]. 2025 Jan 29:2024.08.28.610186. doi: 10.1101/2024.08.28.610186. PubMed |
| Massively parallel assessment of gene regulatory activity at human cortical structure associated variants. Matoba N, McAfee JC, Krupa O, Bell J, Le BD, Valone JM, Crawford GE, Won H, Stein JL. bioRxiv [Preprint]. 2025 Feb 13:2025.02.08.635393. doi: 10.1101/2025.02.08.635393. PubMed |
| Target cell adhesion limits macrophage phagocytosis and promotes trogocytosis. Rollins K, Fiaz S, Morrissey M. bioRxiv [Preprint]. 2025 Feb 8:2025.02.06.636906. doi: 10.1101/2025.02.06.636906. PubMed |
| Astrocytic-supplied cholesterol drives synaptic gene expression programs in developing neurons and downstream astrocytic transcriptional programs. Vartiainen E, Liyanage D, Mazureac I, Battaglia RA, Tegtmeyer M, He JX, Rasanen N, Sealock J, McCarroll S, Nehme R, Pietilainen O. bioRxiv [Preprint]. 2025 Jan 28:2025.01.28.635252. doi: 10.1101/2025.01.28.635252. PubMed |
| Haplotype rather than single causal variants effects contribute to regulatory gene expression associations in human myeloid cells. Greenwood E, Cao M, Lee CM, Liu A, Moyo B, Bao G, Gibson G. bioRxiv [Preprint]. 2025 Jan 30:2025.01.30.635675. doi: 10.1101/2025.01.30.635675. PubMed |
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| TRIP13 protects pancreatic cancer cells against intrinsic and therapy-induced DNA replication stress. Anand JR, Droby GN, Joseph S, Patel U, Zhang X, Klomp JA, Der CJ, Purvis JE, Wolff SC, Bowser J, Vaziri C. bioRxiv [Preprint]. 2025 Jan 27:2025.01.26.634889. doi: 10.1101/2025.01.26.634889. PubMed |
| Higher throughput assays for understanding the pathogenicity of variants of unknown significance (VUS) in the RPE65 gene. Pormehr LA, Manian KV, Cho HE, Comander J. bioRxiv [Preprint]. 2025 Feb 5:2025.01.31.635952. doi: 10.1101/2025.01.31.635952. PubMed |
| Listeria monocytogenes cell-to-cell spread bypasses nutrient limitation for replicating intracellular bacteria. Radhakrishnan P, Theriot JA. bioRxiv [Preprint]. 2025 Feb 1:2025.01.31.635960. doi: 10.1101/2025.01.31.635960. PubMed |
| Single-cell sequencing elucidates the mechanism of NUSAP1 in glioma and its diagnostic and prognostic significance. Zhao MY, Shen ZL, Dai H, Xu WY, Wang LN, Gu Y, Zhao JH, Yu TH, Wang CZ, Xu JF, Chen GJ, Chen DH, Hong WM, Zhang F. Front Immunol. 2025 Feb 5;16:1512867. doi: 10.3389/fimmu.2025.1512867. eCollection 2025. PubMed |
| Mechanism of Centrosomal Protein 55 (CEP55) Loading Into Exosomes. Dahlstroem C, Barezani J, Li J, Sopelniak K, Muhs S, Schneider C, Thunauer R, Reimer R, Windhorst S. J Extracell Vesicles. 2025 Feb;14(2):e70046. doi: 10.1002/jev2.70046. PubMed |
| Lanatoside C activates the E3 ligase STUB1 to inhibit FOXP3 transcriptional activity and promote antitumor immunity. Zhou Q, Yang T, Yu X, Li B, Liu J, Mao Y, Guo R, Feng Z, Zhou L, Zeng G, Li N, Liang J, Liu L, Feng P, Shu HB, Chen L. EMBO Mol Med. 2025 Mar;17(3):563-588. doi: 10.1038/s44321-025-00200-y. Epub 2025 Feb 20. PubMed |
| CRISPR screen reveals modifiers of rAAV production including known rAAV infection genes playing an unexpected role in vector production. O'Driscoll EE, Arora S, Lang JF, Davidson BL, Shalem O. Mol Ther Methods Clin Dev. 2025 Jan 17;33(1):101408. doi: 10.1016/j.omtm.2025.101408. eCollection 2025 Mar 13. PubMed |
| Restraint of inflammasome-driven cytokine responses through the mRNA stability protein TTP. O'Keefe ME, Kondolf HC, De Santis S, Pizarro TT, Abbott DW. Cell Rep. 2025 Mar 25;44(3):115340. doi: 10.1016/j.celrep.2025.115340. Epub 2025 Feb 20. PubMed |
| Rapid and high-throughput screening of proteolysis targeting chimeras using a dual-reporter system expressing fluorescence protein and luciferase. Meng S, Meng Y, Yang X, Yu W, Li B, Liu T, Zhang J, Ren X, Zhang L. BMC Biol. 2025 Feb 21;23(1):51. doi: 10.1186/s12915-025-02153-7. PubMed |
| Integration of single-cell and bulk RNA sequencing to identify a distinct tumor stem cells and construct a novel prognostic signature for evaluating prognosis and immunotherapy in LUAD. Zhao F, Chen M, Wu T, Ji M, Li F. J Transl Med. 2025 Feb 22;23(1):222. doi: 10.1186/s12967-025-06243-6. PubMed |
| Distinct outcomes from targeted perturbations of the multi-subunit SCF(Skp2) E3 ubiquitin ligase in blocking Trp53/Rb1-null prostate tumorigenesis. Xue Y, Zhu L, Karan S, Locker JD, Branch C, Zhang J, Hoang B, Maianti JP, Zhao H, Schwartz EL. Commun Biol. 2025 Feb 22;8(1):278. doi: 10.1038/s42003-025-07662-3. PubMed |
| CCCTC-binding factor N-terminal domain regulates clustered protocadherin gene expression by enhancing cohesin processivity. Zhang Y, Wu Q. J Biol Chem. 2025 Apr;301(4):108337. doi: 10.1016/j.jbc.2025.108337. Epub 2025 Feb 21. PubMed |
| A functional map of phosphoprotein phosphatase regulation identifies an evolutionary conserved reductase for the catalytic metal ions. Meeusen B, Ambjorn SM, Veis J, Riley RC, Vit G, Brauer BL, Moller MH, Greiner EC, Chan CB, Weisser MB, Garvanska DH, Zhu H, Davey NE, Kettenbach AN, Ogris E, Nilsson J. bioRxiv [Preprint]. 2025 Feb 16:2025.02.12.637884. doi: 10.1101/2025.02.12.637884. PubMed |
| Genomic and functional adaptations in guanylate-binding protein 5 (GBP5) highlight specificities of bat antiviral innate immunity. Le Corf A, Maesen S, Loyer C, Vazquez JM, Lauterbur ME, Sareoua L, Gray-Sandoval G, Cimarelli A, Rey C, Sudmant PH, Enard D, Etienne L. bioRxiv [Preprint]. 2025 Feb 15:2025.02.11.637683. doi: 10.1101/2025.02.11.637683. PubMed |
| Optical Pooled Screening for the Discovery of Regulators of the Alternative Lengthening of Telomeres Pathway. Quintanilla I, Azeroglu B, Sagar MAK, Stracker TH, Denchi EL, Pegoraro G. bioRxiv [Preprint]. 2025 Feb 16:2025.02.15.638448. doi: 10.1101/2025.02.15.638448. PubMed |
| CD47 prevents Rac-mediated phagocytosis through Vav1 dephosphorylation. Miller WD, Mishra AK, Sheedy CJ, Bond A, Gardner BM, Montell DJ, Morrissey MA. bioRxiv [Preprint]. 2025 Feb 12:2025.02.11.637707. doi: 10.1101/2025.02.11.637707. PubMed |
| A novel alpha-synuclein K58N missense variant in a patient with Parkinson's disease. Al-Azzani M, Weber S, Ramalingam N, Ramon M, Shvachiy L, Mestre G, Zech M, Sicking K, de Opakua AI, Jayanthi V, Amaral L, Agarwal A, Chandran A, Chaves SR, Winkelmann J, Trenkwalder C, Schwager M, Pauli S, Dettmer U, Fernandez CO, Lautenschlager J, Zweckstetter M, Busnadiego RF, Mollenhauer B, Outeiro TF. medRxiv [Preprint]. 2025 Feb 14:2025.02.07.25321793. doi: 10.1101/2025.02.07.25321793. PubMed |
| The Glycosyltransferase XYLT1 Activates NF-kappaB Signaling to Promote Metastasis of Early-Stage Lung Adenocarcinoma. Han J, Du J, Li X, Zhou Q, Zeng J, Lin JT, Zhou W, Cai J, Ye Y, Yang B, Wang J, Zhou X, Lian R, Yang Y, Zhu X, Guan H, Liu L, Cai J, Wu J, Li Y, Li M, Tian H. Cancer Res. 2025 May 2;85(9):1628-1643. doi: 10.1158/0008-5472.CAN-24-1893. PubMed |
| Circadian clock features define novel subtypes among breast cancer cells and shape drug sensitivity. Ector C, Didier J, De Landtsheer S, Nordentoft MS, Schmal C, Keilholz U, Herzel H, Kramer A, Sauter T, Granada AE. Mol Syst Biol. 2025 Apr;21(4):315-340. doi: 10.1038/s44320-025-00092-7. Epub 2025 Feb 24. PubMed |
| TMEM97 governs partial epithelial-mesenchymal transition of retinal pigment epithelial cells via the CTNND2-ADAM10 axis. Li J, Nagasaka Y, Shen H, Zhou X, Ma J, Trevisan-Silva D, Sherman NE, Ambati J, Gelfand BD, Guo LW. Mol Ther Nucleic Acids. 2025 Jan 21;36(1):102460. doi: 10.1016/j.omtn.2025.102460. eCollection 2025 Mar 11. PubMed |
| Combinational Inhibition of MEK and AKT Synergistically Induces Melanoma Stem Cell Apoptosis and Blocks NRAS Tumor Growth. Alobaidi R, Islam N, Olkey T, Haribabu Y, Shamo M, Sykora P, Simbulan-Rosenthal CM, Rosenthal DS. Cells. 2025 Feb 10;14(4):248. doi: 10.3390/cells14040248. PubMed |
| ATF3-SLC7A7 Axis Regulates mTORC1 Signaling to Suppress Lipogenesis and Tumorigenesis in Hepatocellular Carcinoma. Zhang Q, Zhu F, Tong Y, Huang Y, Zhang J. Cells. 2025 Feb 11;14(4):253. doi: 10.3390/cells14040253. PubMed |
| RNF20 dual regulation of MDA5 signaling to maintain immune homeostasis in chickens. Wang J, Liu Q, Zhang K, Zhao S, Shao Q, Fu F, Ma J, Wang Z, Yan Y-x, Wang H, Sun J, Cheng Y. J Virol. 2025 Mar 18;99(3):e0200824. doi: 10.1128/jvi.02008-24. Epub 2025 Feb 25. PubMed |
| Engineering of CD8(+) T cells with an HIV-specific synthetic notch receptor to secrete broadly therapeutic antibodies for combining antiviral humoral and cellular immune responses. Meng L, Zhao H, Chang S, Li W, Tian Y, Wang R, Wang L, Gu T, Wu J, Yu B, Wang C, Yu X. mBio. 2025 Apr 9;16(4):e0383924. doi: 10.1128/mbio.03839-24. Epub 2025 Feb 25. PubMed |
| Genome-wide profiling of N6-methyladenosine-modified pseudogene-derived long noncoding RNAs reveals the tumour-promoting and innate immune-restraining function of RPS15AP12 in ovarian cancer. Xu J, Ren Y, Lu J, Qin F, Yang D, Tang C, Yang Y, Xu J, Liu T, Yi P. Clin Transl Med. 2025 Mar;15(3):e70249. doi: 10.1002/ctm2.70249. PubMed |
| Impaired MC3T3-E1 osteoblast differentiation triggered by oncogenic HRAS is rescued by the farnesyltransferase inhibitor Tipifarnib. Andrasch Y, Ireri MM, Gander J, Timm AS, Chennappan S, Fidan M, Engler M, Cirstea IC. Sci Rep. 2025 Feb 26;15(1):6832. doi: 10.1038/s41598-025-91592-x. PubMed |
| Glutathione peroxidase 4 (GPX4) and obesity interact to impact tumor progression and treatment response in triple negative breast cancer. Devericks EN, Brosnan BH, Ho AN, Glenny EM, Malian HM, Teegarden D, Wendt MK, Coleman MF, Hursting SD. Cancer Metab. 2025 Feb 25;13(1):11. doi: 10.1186/s40170-025-00380-8. PubMed |
| Stbd1 stimulates AMPK signaling and alleviates insulin resistance in an in vitro hepatocyte model. Theodoulou A, Speckmann T, Potamiti L, Baba O, Morita T, Drousiotou A, Panayiotidis MI, Schurmann A, Petrou PP. FEBS J. 2025 Jun;292(11):2882-2901. doi: 10.1111/febs.70040. Epub 2025 Feb 25. PubMed |
| Association of Selected STAT Inhibitors with Prolactin-Induced Protein (PIP) in Breast Cancer. Jablonska K, Kmiecik A, Nowinska K, Piotrowska A, Suchanski J, Ratajczak-Wielgomas K, Partynska A, Romanowicz H, Smolarz B, Matkowski R, Dziegiel P. Int J Mol Sci. 2025 Feb 7;26(4):1416. doi: 10.3390/ijms26041416. PubMed |
| The IGF2BP1 oncogene is a druggable m(6)A-dependent enhancer of YAP1-driven gene expression in ovarian cancer. Schott A, Simon T, Muller S, Rausch A, Busch B, Glass M, Misiak D, Dipto M, Elrewany H, Peters LM, Tripathee S, Ghazy E, Muller F, Rolnik RB, Lederer M, Hmedat A, Vetter M, Wallwiener M, Sippl W, Huttelmaier S, Bley N. NAR Cancer. 2025 Feb 24;7(1):zcaf006. doi: 10.1093/narcan/zcaf006. eCollection 2025 Mar. PubMed |
| Local soft niches in mechanically heterogeneous primary tumors promote brain metastasis via mechanotransduction-mediated HDAC3 activity. Tang K, Zheng Y, Hu G, Xin Y, Li K, Zhang C, Chen X, Zhang B, Li X, Hu B, Jia Q, Zheng YP, Yang M, Tan Y. Sci Adv. 2025 Feb 28;11(9):eadq2881. doi: 10.1126/sciadv.adq2881. Epub 2025 Feb 26. PubMed |
| NGF regulates survival and differentiation of umbilical mesenchymal stem/stromal cells into GABAergic, dopaminergic and cholinergic lineages. Borkowska P, Kowalczyk M, Zielinska A, Poskrobko K, Rother MB, Paul-Samojedny M, Kowalski J. Eur J Pharm Sci. 2025 May 1;208:107053. doi: 10.1016/j.ejps.2025.107053. Epub 2025 Feb 24. PubMed |
| A benchmark comparison of CRISPRn guide-RNA design algorithms and generation of small single and dual-targeting libraries to boost screening efficiency. Lukasiak S, Kalinka A, Gupta N, Papadopoulos A, Saeed K, McDermott U, Hannon GJ, Ross-Thriepland D, Walter D. BMC Genomics. 2025 Feb 26;26(1):198. doi: 10.1186/s12864-025-11386-3. PubMed |
| Radiotherapy resistance driven by Asparagine endopeptidase through ATR pathway modulation in breast cancer. Morillo-Huesca M, G Lopez-Cepero I, Conesa-Bakkali R, Tome M, Watts C, Huertas P, Moreno-Bueno G, Duran RV, Martinez-Fabregas J. J Exp Clin Cancer Res. 2025 Feb 27;44(1):74. doi: 10.1186/s13046-025-03334-6. PubMed |
| Maintenance of p-eIF2alpha levels by the eIF2B complex is vital for colorectal cancer. Skapik IP, Giacomelli C, Hahn S, Deinlein H, Gallant P, Diebold M, Biayna J, Hendricks A, Olimski L, Otto C, Kastner C, Wolf E, Schulein-Volk C, Maurus K, Rosenwald A, Schleussner N, Jackstadt RF, Schlegel N, Germer CT, Bushell M, Eilers M, Schmidt S, Wiegering A. EMBO J. 2025 Apr;44(7):2075-2105. doi: 10.1038/s44318-025-00381-9. Epub 2025 Feb 27. PubMed |
| Accumulation of Damaging Lipids in the Arf1-Ablated Neurons Promotes Neurodegeneration through Releasing mtDNA and Activating Inflammatory Pathways in Microglia. Li X, Jin S, Wang D, Wu Y, Tang X, Liu Y, Yao T, Han S, Sun L, Wang Y, Hou SX. Adv Sci (Weinh). 2025 Apr;12(16):e2414260. doi: 10.1002/advs.202414260. Epub 2025 Feb 28. PubMed |
| Norovirus co-opts NINJ1 for selective protein secretion. Song J, Zhang L, Moon S, Fang A, Wang G, Gheshm N, Loeb SA, Cao P, Wallace JR, Alfajaro MM, Strine MS, Beatty WL, Jamieson AM, Orchard RC, Robinson BA, Nice TJ, Wilen CB, Orvedahl A, Reese TA, Lee S. Sci Adv. 2025 Feb 28;11(9):eadu7985. doi: 10.1126/sciadv.adu7985. Epub 2025 Feb 28. PubMed |
| Metabolic engineering to facilitate anti-tumor immunity. Schild T, Wallisch P, Zhao Y, Wang YT, Haughton L, Chirayil R, Pierpont K, Chen K, Nunes-Violante S, Cross J, de Stanchina E, Thompson CB, Scheinberg DA, Perry JSA, Keshari KR. Cancer Cell. 2025 Mar 10;43(3):552-562.e9. doi: 10.1016/j.ccell.2025.02.004. Epub 2025 Feb 27. PubMed |
| Bone morphogenetic protein (BMP) signaling determines neuroblastoma cell fate and sensitivity to retinoic acid. Pan M, Zhang Y, Wright WC, Liu X, Passaia B, Currier D, Low J, Chapple RH, Steele JA, Connelly JP, Ju B, Plyler E, Lu M, Loughran AJ, Yang L, Abraham BJ, Pruett-Miller SM, Freeman B 3rd, Campbell GE, Dyer MA, Chen T, Stewart E, Koo S, Sheppard H, Easton J, Geeleher P. Nat Commun. 2025 Feb 28;16(1):2036. doi: 10.1038/s41467-025-57185-y. PubMed |
| ACSS2 drives senescence-associated secretory phenotype by limiting purine biosynthesis through PAICS acetylation. Yang L, You J, Yang X, Jiao R, Xu J, Zhang Y, Mi W, Zhu L, Ye Y, Ren R, Min D, Tang M, Chen L, Li F, Liu P. Nat Commun. 2025 Feb 28;16(1):2071. doi: 10.1038/s41467-025-57334-3. PubMed |
HIF regulates multiple translated endogenous retroviruses: Implications for cancer immunotherapy.
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| Integrated computational analysis identifies therapeutic targets with dual action in cancer cells and T cells. Luo C, Zhang R, Guo R, Wu L, Xue T, He Y, Jin Y, Zhao Y, Zhang Z, Zhang P, Ye S, Li X, Li D, Zhang W, Wang C, Lai L, Pan-Hammarstrom Q, Wucherpfennig KW, Gao Z, Pan D, Zeng Z. Immunity. 2025 Mar 11;58(3):745-765.e9. doi: 10.1016/j.immuni.2025.02.007. Epub 2025 Feb 28. PubMed |
| The NF1 tumor suppressor regulates PD-L1 and immune evasion in melanoma. Berry D, Moldoveanu D, Rajkumar S, Lajoie M, Lin T, Tchelougou D, Sakthivel S, Sharon I, Bernard A, Pelletier S, Ripstein Y, Spatz A, Miller WH, Jamal R, Lapointe R, Mes-Masson AM, Petrecca K, Meguerditchian AN, Richardson K, Wang B, Chergui M, Guiot MC, Watters K, Stagg J, Schmeing TM, Rodier F, Turcotte S, Mihalcioiu C, Meterissian S, Watson IR. Cell Rep. 2025 Mar 25;44(3):115365. doi: 10.1016/j.celrep.2025.115365. Epub 2025 Mar 1. PubMed |
| Screening the human druggable genome identifies ABHD17B as an anti-fibrotic target in hepatic stellate cells. Li W, Sparks RP, Sun C, Yang Y, Pantano L, Kirchner R, Arghiani N, Weilheimer A, Toles BJ, Chen JY, Moran SP, Barrera V, Li Z, Zhou P, Brassil ML, Wrobel D, Ho Sui SJ, Aspnes G, Schuler M, Smith J, Medoff BD, Zhou C, Boustany-Kari CM, Rippmann JF, Santos DM, Doerner JF, Mullen AC. Nat Commun. 2025 Mar 2;16(1):2109. doi: 10.1038/s41467-025-56900-z. PubMed |
| SOX9 haploinsufficiency reveals SOX9-Noggin interaction in BMP-SMAD signaling pathway in chondrogenesis. Ha TY, Chan SW, Wang Z, Law PWN, Miu KK, Lu G, Chan WY. Cell Mol Life Sci. 2025 Mar 2;82(1):99. doi: 10.1007/s00018-025-05622-y. PubMed |
| Dickkopf-1 promotes tumor progression of gefitinib- resistant non-small cell lung cancer through cancer cell-fibroblast interactions. Choi M, Choi YJ, Lee YJ, Lee Y, Chung JH, Kang KW. Exp Hematol Oncol. 2025 Mar 1;14(1):24. doi: 10.1186/s40164-025-00616-9. PubMed |
| Synergistic RAS-MAPK and AKT Activation in MYC-Driven Tumors via Adjacent PVT1 Rearrangements. Tiwari A, Paithane U, Friedlein J, Tashiro K, Saulnier O, Barbosa K, Trinh Q, Hall B, Saha S, Soni A, Nakashima T, Bobkov A, Fujimoto LM, Murad R, Maurya S, Saraswat M, Sarmashghi S, Lange JT, Wu S, Masihi MB, Ghosh S, Hemmati G, Chapman O, Hendrikse L, James B, Luebeck J, Eisemann T, Tzaridis T, Rohila D, Leary R, Varshney J, Konety B, Dehm SM, Kawakami Y, Beroukhim R, Largaespada DA, Stein L, Chavez L, Suzuki H, Weiss WA, Zhao J, Deshpande A, Wechsler-Reya RJ, Taylor MD, Bagchi A. bioRxiv [Preprint]. 2025 Feb 22:2025.02.17.638454. doi: 10.1101/2025.02.17.638454. PubMed |
| CellFIE: Integrating Pathway Discovery With Pooled Profiling of Perturbations Uncovers Pathways of Huntington's Disease, Including Genetic Modifiers of Neuronal Development and Morphology. Kang B, Murphy M, Ng CW, Leventhal MJ, Huynh N, Im E, Danquah S, Housman DE, Nehme R, Farhi SL, Fraenkel E. bioRxiv [Preprint]. 2025 Feb 22:2025.02.19.639023. doi: 10.1101/2025.02.19.639023. PubMed |
| Succinate Dehydrogenase loss causes cascading metabolic effects that impair pyrimidine biosynthesis. Hart ML, Davidsen K, Danquah S, Zheng E, Sokolov D, Sullivan LB. bioRxiv [Preprint]. 2025 Feb 19:2025.02.18.638948. doi: 10.1101/2025.02.18.638948. PubMed |
| Pyrimethamine and a potent analogue WCDD115 inhibit NRF2 by suppressing DHFR and one-carbon metabolism. Chembo J, Bowman BM, Lapak K, Wilkerson E, Paiboonrungruang C, Cho K, Medcalf MR, Patti GJ, Dolle RE, Chen X, Zolkind P, Major MB. bioRxiv [Preprint]. 2025 Feb 17:2025.02.13.637433. doi: 10.1101/2025.02.13.637433. PubMed |
| An RNA Splicing System that Excises Transposons from Animal mRNAs. Zhao LW, Nardone C, Paulo JA, Elledge SJ, Kennedy S. bioRxiv [Preprint]. 2025 Feb 17:2025.02.14.638102. doi: 10.1101/2025.02.14.638102. PubMed |
| Proximity proteomics reveals a mechanism of fatty acid transfer at lipid droplet-mitochondria- endoplasmic reticulum contact sites. Bezawork-Geleta A, Devereux CJ, Keenan SN, Lou J, Cho E, Nie S, De Souza DP, Narayana VK, Siddall NA, Rodrigues CHM, Portelli S, Zheng T, Nim HT, Ramialison M, Hime GR, Dodd GT, Hinde E, Ascher DB, Stroud DA, Watt MJ. Nat Commun. 2025 Mar 3;16(1):2135. doi: 10.1038/s41467-025-57405-5. PubMed |
| Nematode serine protease inhibitor SPI-I8 negatively regulates host NF-kappaB signalling by hijacking MKRN1-mediated polyubiquitination of RACK1. Wu F, Chen Y, Chen X, Tong D, Zhou J, Du Z, Yao C, Yang Y, Du A, Ma G. Commun Biol. 2025 Mar 3;8(1):356. doi: 10.1038/s42003-025-07803-8. PubMed |
Tuning the tropism and infectivity of SARS-CoV-2 virus-like particles for mRNA delivery.
Yang Q, Davidson BA, Pajic P, Chen X, Gokcumen O, Gao M, Neelamegham S.
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PubMed
Associated Plasmids |
| Gut dysbiosis conveys psychological stress to activate LRP5/beta-catenin pathway promoting cancer stemness. Cui B, Luo H, He B, Liu X, Lv D, Zhang X, Su K, Zheng S, Lu J, Wang C, Yang Y, Zhao Z, Liu X, Wang X, Zhao Y, Nie X, Jiang Y, Zhang Z, Liu C, Chen X, Cai A, Lv Z, Liu Z, An F, Zhang Y, Yan Q, Kelley KW, Xu G, Xu L, Liu Q, Peng F. Signal Transduct Target Ther. 2025 Mar 5;10(1):79. doi: 10.1038/s41392-025-02159-1. PubMed |
| p53 regulates DREAM complex-mediated repression in a p21-independent manner. Agrawal R, Sengupta S. EMBO J. 2025 Apr;44(8):2279-2297. doi: 10.1038/s44318-025-00402-7. Epub 2025 Mar 4. PubMed |
| Recognition of MR1-antigen complexes by TCR Vgamma9Vdelta2. Loureiro JP, Vacchini A, Berloffa G, Devan J, Schaefer V, Nosi V, Colombo R, Beshirova A, Montanelli G, Meyer B, Sharpe T, Chancellor A, Recher M, Mori L, De Libero G. Front Immunol. 2025 Feb 18;16:1519128. doi: 10.3389/fimmu.2025.1519128. eCollection 2025. PubMed |
| Deletion of Xist repeat B disrupts cell cycle and asymmetric cell division through Usp9x hyperactivation in mice. Liang M, Zhang L, Gong H, Yang L, Wang H, Song N, Lai L, Xie W, Li Z. Nucleic Acids Res. 2025 Feb 27;53(5):gkaf142. doi: 10.1093/nar/gkaf142. PubMed |
| Mis-splicing drives loss of function of p53E224D point mutation. Lock IC, Leisenring NH, Floyd W, Xu ES, Luo L, Ma Y, Mansell EC, Cardona DM, Lee CL, Kirsch DG. PLoS One. 2025 Mar 5;20(3):e0318856. doi: 10.1371/journal.pone.0318856. eCollection 2025. PubMed |
| Structure-function relationship of ASH1L and histone H3K36 and H3K4 methylation. Vann KR, Sharma R, Hsu CC, Devoucoux M, Tencer AH, Zeng L, Lin K, Zhu L, Li Q, Lachance C, Ospina RR, Tong Q, Cheung KL, Yang S, Biswas S, Xuan H, Gatchalian J, Alamillo L, Wang J, Jang SM, Klein BJ, Lu Y, Ernst P, Strahl BD, Rothbart SB, Walsh MJ, Cleary ML, Cote J, Shi X, Zhou MM, Kutateladze TG. Nat Commun. 2025 Mar 6;16(1):2235. doi: 10.1038/s41467-025-57556-5. PubMed |
| Enhancing Prime Editing Efficiency Through Modulation of Methylation on the Newly Synthesized DNA Strand and Prolonged Expression. Han X, Xu X, Xiong Y, Zhao G, He R, Su Y, Li S, Zhao C, Xi X, Zhao Y, Xu X, Xie S, Wang H, Li X, Zhao S, Ruan J. Adv Sci (Weinh). 2025 May;12(17):e2417790. doi: 10.1002/advs.202417790. Epub 2025 Mar 7. PubMed |
| Heme oxygenase 1‑overexpressing bone marrow mesenchymal stem cell‑derived exosomes suppress interleukin‑1 beta‑induced apoptosis and aging of nucleus pulposus cells. Zhang H, Zhang D, Wang H, Liu Y, Ding W, Fan G, Meng X. Mol Med Rep. 2025 May;31(5):116. doi: 10.3892/mmr.2025.13481. Epub 2025 Mar 7. PubMed |
| Rac1 overexpression promotes Treg-derived cytokines to mediate choroidal neovascularization in wet age-related macular degeneration. Li J, Ren Y, Li H, Zheng Z. Braz J Med Biol Res. 2025 Mar 3;58:e14187. doi: 10.1590/1414-431X2024e14187. eCollection 2025. PubMed |
| Isocyanic acid-mediated NLRP3 carbamoylation reduces NLRP3-NEK7 interaction and limits inflammasome activation. Zhang Z, Chen C, Liu C, Sun P, Liu P, Fang S, Li X. Sci Adv. 2025 Mar 7;11(10):eadq4266. doi: 10.1126/sciadv.adq4266. Epub 2025 Mar 7. PubMed |
| Targeted nanoparticle delivery system for tumor-associated macrophage reprogramming to enhance TNBC therapy. Dong X, Wang X, Zheng X, Jiang H, Liu L, Ma N, Wang S. Cell Biol Toxicol. 2025 Mar 8;41(1):58. doi: 10.1007/s10565-025-10001-1. PubMed |
| Single extracellular vesicle detection assay identifies membrane-associated alpha-synuclein as an early-stage biomarker in Parkinson's disease. Yan S, Zhang W, Li X, Dutta S, Castle AR, Liu Y, Sahoo A, Lam CL, Gatford NJF, Hu MT, Li CZ, Jiang C, Shu B, Tofaris GK. Cell Rep Med. 2025 Mar 18;6(3):101999. doi: 10.1016/j.xcrm.2025.101999. Epub 2025 Mar 7. PubMed |
| HRP2 regulating MICU1-mediated Ca(2+) overload to dictate chemoresistance of multiple myeloma. Li Q, Peng Z, Lin L, Zhang Z, Ma J, Chen L, Liu S, Gao S, Jia L, Wang J, Cao Z, Zhao X, Liu Z, Wang Y. Neoplasia. 2025 Apr;62:101150. doi: 10.1016/j.neo.2025.101150. Epub 2025 Mar 8. PubMed |
| Resistance to Radiation Enhances Metastasis by Altering RNA Metabolism. Kumar A, Kishimoto K, Goel HL, Wisniewski CA, Li R, Pacheco B, Zhu LJ, Flavahan WA, Mercurio AM. bioRxiv [Preprint]. 2025 Feb 25:2025.02.19.638943. doi: 10.1101/2025.02.19.638943. PubMed |
| Multiplexed in vivo base editing identifies functional gene-variant-context interactions. Acosta J, Johnson GA, Gould SI, Dong K, Lendner Y, Detres D, Atwa O, Bulkens J, Gruber S, Contreras ME, Wuest AN, Narendra VK, Hemann MT, Sanchez-Rivera FJ. bioRxiv [Preprint]. 2025 Feb 26:2025.02.23.639770. doi: 10.1101/2025.02.23.639770. PubMed |
| Succinate dehydrogenase activity supports de novo purine synthesis. Nengroo MA, Klein AT, Carr HS, Vidal-Cruchez O, Sahu U, McGrail DJ, Sahni N, Gao P, Asara JM, Shah H, Mendillo ML, Ben-Sahra I. bioRxiv [Preprint]. 2025 Mar 1:2025.02.26.640389. doi: 10.1101/2025.02.26.640389. PubMed |
| A genome wide CRISPR screen reveals novel determinants of long-lived plasma cell secretory capacity. D'Souza LJ, Young JN, Coffman H, Petrow EP Jr, Bhattacharya D. bioRxiv [Preprint]. 2025 Mar 2:2025.02.28.640639. doi: 10.1101/2025.02.28.640639. PubMed |
| The Adhesion GPCR ADGRL2 engages Galpha13 to Enable Epidermal Differentiation. Yang X, He F, Porter DF, Garbett K, Meyers RM, Reynolds DL, Lan Huong Bui D, Hong A, Ducoli L, Siprashvili Z, Lopez-Pajares V, Mondal S, Ko L, Jing Y, Tao S, Singal B, Sando R, Skiniotis G, Khavari PA. bioRxiv [Preprint]. 2025 Apr 14:2025.02.19.639154. doi: 10.1101/2025.02.19.639154. PubMed |
| Harnessing transcriptional regulation of alternative end-joining to predict cancer treatment. Espin R, Medina-Jover F, Siguenza-Andrade J, Farran-Matas S, Mateo F, Figueras A, Sanz RT, Vicent GP, Shabbir A, Ruiz-Auladell L, Racionero-Andres E, Garcia I, Baiges A, Franco-Luzon L, Martinez-Tebar A, Pardo-Cea MA, Martinez-Iniesta M, Wang XC, Cuyas E, Menendez JA, Lopez-Cerda M, Munoz P, Richaud I, Raya A, Fabregat I, Villanueva A, Serrat X, Ceron J, Alemany M, Guix I, Herencia-Ropero A, Serra V, Krishnan R, Mekhail K, Hakem R, Bruna J, Barcellos-Hoff MH, Vinals F, Aytes A, Pujana MA. NAR Cancer. 2025 Mar 7;7(1):zcaf007. doi: 10.1093/narcan/zcaf007. eCollection 2025 Mar. PubMed |
| TNF inhibits NKCC2 phosphorylation by a calcineurin-dependent pathway. Hao S, Lasaracina AP, Epps J, Ferreri NR. Am J Physiol Renal Physiol. 2025 Apr 1;328(4):F489-F500. doi: 10.1152/ajprenal.00251.2024. Epub 2025 Mar 10. PubMed |
| CRB2 depletion induces YAP signaling and disrupts mechanosensing in podocytes. Sun Y, Kronenberg NM, Sethi SK, Dash SN, Kovalik ME, Sempowski B, Strickland S, Raina R, Sperati CJ, Tian X, Ishibe S, Hall G, Gather MC. Am J Physiol Renal Physiol. 2025 Apr 1;328(4):F578-F595. doi: 10.1152/ajprenal.00318.2024. Epub 2025 Mar 10. PubMed |
| Antibody reactivity against EBNA1 and GlialCAM differentiates multiple sclerosis patients from healthy controls. Sattarnezhad N, Kockum I, Thomas OG, Liu Y, Ho PP, Barrett AK, Comanescu AI, Wijeratne TU, Utz PJ, Alfredsson L, Steinman L, Robinson WH, Olsson T, Lanz TV. Proc Natl Acad Sci U S A. 2025 Mar 18;122(11):e2424986122. doi: 10.1073/pnas.2424986122. Epub 2025 Mar 10. PubMed |
| A positive feedback loop between SMAD3 and PINK1 in regulation of mitophagy. Tang M, Rong D, Gao X, Lu G, Tang H, Wang P, Shao NY, Xia D, Feng XH, He WF, Chen W, Lu JH, Liu W, Shen HM. Cell Discov. 2025 Mar 11;11(1):22. doi: 10.1038/s41421-025-00774-4. PubMed |
| TET2 deficiency increases the competitive advantage of hematopoietic stem and progenitor cells through upregulation of thrombopoietin receptor signaling. Yang Y, Cathelin S, Liu ACH, Subedi A, Maher A, Hosseini M, Manikoth Ayyathan D, Vanner R, Chan SM. Nat Commun. 2025 Mar 10;16(1):2384. doi: 10.1038/s41467-025-57614-y. PubMed |
| Suppression of stress granule formation is a vulnerability imposed by mutant p53. Thoenen E, Ranjan A, Parrales A, Nishikawa S, Dixon DA, Oka S, Iwakuma T. Nat Commun. 2025 Mar 10;16(1):2365. doi: 10.1038/s41467-025-57539-6. PubMed |
| Kallikrein-8 mediates furin-independent Activin-A precursor processing to stimulate tumor growth in melanoma. Bulliard M, Pinjusic K, Iacobucci L, Schmuziger C, Fournier N, Constam DB. Nat Commun. 2025 Mar 10;16(1):2354. doi: 10.1038/s41467-025-57661-5. PubMed |
| Compound screening in human airway basal cells identifies Wnt pathway activators as potential pro-regenerative therapies. Ishii Y, Orr JC, El Mdawar MB, de Pilger DRB, Pearce DR, Lazarus KA, Graham RE, Nikolic MZ, Ketteler R, Carragher NO, Janes SM, Hynds RE. J Cell Sci. 2025 Apr 1;138(7):jcs263487. doi: 10.1242/jcs.263487. Epub 2025 Apr 14. PubMed |
| LNS8801: An Enantiomerically Pure Agonist of the G Protein-Coupled Estrogen Receptor Suitable for Clinical Development. Natale CA, Mercado S, Zhuang R, Aguirre-Portoles C, Olayide I, Arnatt CK, Seykora JT, Garyantes TK, Luke W, Ridky TW. Cancer Res Commun. 2025 Apr 1;5(4):556-568. doi: 10.1158/2767-9764.CRC-24-0632. PubMed |
| BET degraders reveal BRD4 disruption of 7SK and P-TEFb is critical for effective reactivation of latent HIV in CD4+ T-cells. Turner A-MW, Bashore FM, Falcinelli SD, Fox JA, Keller AL, Fenton AD, Geyer RF, Allard B, Kirchherr JL, Archin NM, James LI, Margolis DM. J Virol. 2025 Apr 15;99(4):e0177724. doi: 10.1128/jvi.01777-24. Epub 2025 Mar 11. PubMed |
| Epigenetic deprogramming by disruption of CIZ1-RNA nuclear assemblies in early-stage breast cancers. Turvey GL, Lopez de Alba E, Stewart E, Cook H, Alalti A, Gawne RT, Ainscough JF, Mason AS, Coverley D. J Cell Biol. 2025 May 5;224(5):e202409123. doi: 10.1083/jcb.202409123. Epub 2025 Mar 11. PubMed |
| Collaborative role of two distinct cilium-specific cytoskeletal systems in driving Hedgehog-responsive transcription factor trafficking. Ku PI, Sreeja JS, Chadha A, Williams DS, Engelke MF, Subramanian R. Sci Adv. 2025 Mar 14;11(11):eadt5439. doi: 10.1126/sciadv.adt5439. Epub 2025 Mar 12. PubMed |
| Splenic red pulp macrophages eliminate the liver-resistant Streptococcus pneumoniae from the blood circulation of mice. An H, Huang Y, Zhao Z, Li K, Meng J, Huang X, Tian X, Zhou H, Wu J, Dai Q, Zhang JR. Sci Adv. 2025 Mar 14;11(11):eadq6399. doi: 10.1126/sciadv.adq6399. Epub 2025 Mar 12. PubMed |
| Lipoylation inhibition enhances radiation control of lung cancer by suppressing homologous recombination DNA damage repair. Chiang JC, Shang Z, Rosales T, Cai L, Chen WM, Cai F, Vu H, Minna JD, Ni M, Davis AJ, Timmerman RD, DeBerardinis RJ, Zhang Y. Sci Adv. 2025 Mar 14;11(11):eadt1241. doi: 10.1126/sciadv.adt1241. Epub 2025 Mar 12. PubMed |
| PTPsigma-mediated PI3P regulation modulates neurodegeneration in C9ORF72-ALS/FTD. Zhang Z, Fu X, Wright N, Wang W, Ye Y, Asbury J, Li Y, Zhu C, Wu R, Wang S, Sun S. Neuron. 2025 Apr 16;113(8):1190-1205.e9. doi: 10.1016/j.neuron.2025.02.005. Epub 2025 Mar 11. PubMed |
| Targeting USP8 causes synthetic lethality through degradation of FGFR2 in ARID1A-deficient ovarian clear cell carcinoma. Saito R, Fukushima M, Sasaki M, Okamoto A, Ogiwara H. NPJ Precis Oncol. 2025 Mar 12;9(1):69. doi: 10.1038/s41698-025-00850-8. PubMed |
| MYC ecDNA promotes intratumour heterogeneity and plasticity in PDAC. Fiorini E, Malinova A, Schreyer D, Pasini D, Bevere M, Alessio G, Rosa D, D'Agosto S, Azzolin L, Milite S, Andreani S, Lupo F, Veghini L, Grimaldi S, Pedron S, Castellucci M, Nourse C, Salvia R, Malleo G, Ruzzenente A, Guglielmi A, Milella M, Lawlor RT, Luchini C, Agostini A, Carbone C, Pilarsky C, Sottoriva A, Scarpa A, Tuveson DA, Bailey P, Corbo V. Nature. 2025 Apr;640(8059):811-820. doi: 10.1038/s41586-025-08721-9. Epub 2025 Mar 12. PubMed |
| Crip2 affects vascular development by fine-tuning endothelial cell aggregation and proliferation. Yang S, Zhang X, Li X, Li H. Cell Mol Life Sci. 2025 Mar 13;82(1):110. doi: 10.1007/s00018-025-05624-w. PubMed |
| Development and Characterization of Three Novel FGFR Inhibitor Resistant Cervical Cancer Cell Lines to Help Drive Cervical Cancer Research. Bou Antoun N, Afshan Mahmood HT, Walker AJ, Modjtahedi H, Grose RP, Chioni AM. Int J Mol Sci. 2025 Feb 20;26(5):1799. doi: 10.3390/ijms26051799. PubMed |
| CXCR4 Inhibition Enhances the Efficacy of CD19 Monoclonal Antibody-Mediated Extermination of B-Cell Lymphoma. Khunti N, Kumar M, Datta M, Harelimana JD, Harms M, Albers D, Kirchhoff F, Munch J, Stenger S, Buske C, Maity PC. Int J Mol Sci. 2025 Feb 26;26(5):2024. doi: 10.3390/ijms26052024. PubMed |
| Comprehensive genomic dependency landscape of a human colon cancer organoid. Khalili S, Mohseninia A, Liu C, Banister CE, Heine P, Khazan M, Morrison SE, Gokare P, Cowley GS, Weir BA, Pocalyko D, Bachman KE, Buckhaults PJ. Commun Biol. 2025 Mar 14;8(1):436. doi: 10.1038/s42003-025-07822-5. PubMed |
| Enhanced therapeutic efficacy of anti-PD-1 blockade by targeting LAMP2A inhibits lysosomal degradation of STING and TBK1. Wang X, Zhang D, Xiao J, Wang L, Wang J, Cui X, Tan J, Liu Y, Miao S. Theranostics. 2025 Feb 18;15(7):3207-3222. doi: 10.7150/thno.103426. eCollection 2025. PubMed |
| Targeting platinum-resistant ovarian cancer by disrupting histone and RAD51 lactylation. Sun C, Li X, Teng Q, Liu X, Song L, Schioth HB, Wu H, Ma X, Zhang Z, Qi C, Zhang H, Song K, Zhang Q, Kong B. Theranostics. 2025 Feb 10;15(7):3055-3075. doi: 10.7150/thno.104858. eCollection 2025. PubMed |
| Glioblastoma progression is hindered by melatonin-primed mesenchymal stromal cells through dynamic intracellular and extracellular reorganizations. Olmedo-Moreno L, Panadero-Moron C, Sierra-Parraga JM, Bueno-Fernandez R, Norton ES, Aguilera Y, Mellado-Damas N, Garcia-Tarraga P, Morales-Gallel R, Antequera-Martinez M, Duran RV, Ferrer-Lozano J, Escames G, Garcia-Verdugo JM, Martin-Montalvo A, Guerrero-Cazares H, Capilla-Gonzalez V. Theranostics. 2025 Feb 10;15(7):3076-3097. doi: 10.7150/thno.104143. eCollection 2025. PubMed |
| A microglia clonal inflammatory disorder in Alzheimer's disease. Vicario R, Fragkogianni S, Weber L, Lazarov T, Hu Y, Hayashi SY, Craddock B, Socci ND, Alberdi A, Baako A, Ay O, Ogishi M, Lopez-Rodrigo E, Kappagantula R, Viale A, Iacobuzio-Donahue CA, Zhou T, Ransohoff RM, Chesworth R, Abdel-Wahab O, Boisson B, Elemento O, Casanova JL, Miller WT, Geissmann F. Elife. 2025 Mar 14;13:RP96519. doi: 10.7554/eLife.96519. PubMed |
| The E3 ubiquitin ligase RNF126 facilitates quality control of unimported mitochondrial membrane proteins. Liu D, Huo XY, Zhang X, Zhang ZR. J Biol Chem. 2025 Apr;301(4):108403. doi: 10.1016/j.jbc.2025.108403. Epub 2025 Mar 12. PubMed |
| FoxO3 controls cardiomyocyte proliferation and heart regeneration by regulating Sfrp2 expression in postnatal mice. Xia JB, Liu K, Lin XL, Li HJ, Lin JH, Li L, Liang CQ, Cao Y, Wen N, Liao ZF, Zhao H, Park KS, Song GH, Ye ZB, Cai DQ, Ju ZY, Qi XF. Nat Commun. 2025 Mar 14;16(1):2532. doi: 10.1038/s41467-025-57962-9. PubMed |
| USP7 V517F mutation as a mechanism of inhibitor resistance. Miao YL, Fan F, Cheng YJ, Jia L, Song SS, Huan XJ, Bao XB, Ding J, Yu X, He JX. Nat Commun. 2025 Mar 14;16(1):2526. doi: 10.1038/s41467-025-56981-w. PubMed |
| NLRP4 unlocks an NK/macrophages-centered ecosystem to suppress non-small cell lung cancer. Meng Z, Li J, Wang H, Cao Z, Lu W, Niu X, Yang Y, Li Z, Wang Y, Lu S. Biomark Res. 2025 Mar 14;13(1):44. doi: 10.1186/s40364-025-00756-4. PubMed |
| VIPAS39 confers ferroptosis resistance in epithelial ovarian cancer through exporting ACSL4. Jiang Y, Li J, Wang T, Gu X, Li X, Liu Z, Yue W, Li M. EBioMedicine. 2025 Apr;114:105646. doi: 10.1016/j.ebiom.2025.105646. Epub 2025 Mar 14. PubMed |
| Crohn's Disease-associated variant in laccase domain containing 1 (LACC1) modulates T cell gene expression, metabolism and T cell function. Li Y, Ascui G, Dicker M, Riffelmacher T, Chandra V, Schmiedel B, Chou TF, Vijayanand P, Kronenberg M. Nat Commun. 2025 Mar 15;16(1):2577. doi: 10.1038/s41467-025-57744-3. PubMed |
| The costimulatory domain influences CD19 CAR-T cell resistance development in B-cell malignancies. Krawczyk M, Fernandez-Fuentes N, Fidyt K, Winiarski T, Pepek M, Graczyk-Jarzynka A, Davis J, Bousquets-Munoz P, Puente XS, Menendez P, Benard E, Walchli S, Thomas-Tikhonenko A, Winiarska M. bioRxiv [Preprint]. 2025 Mar 4:2025.02.28.640707. doi: 10.1101/2025.02.28.640707. PubMed |
| A comprehensive map of missense trafficking variants in rhodopsin and their response to pharmacologic correction. Manian KV, Ludwig CH, Zhao Y, Abell N, Yang X, Root DE, Albert ML, Comander J. bioRxiv [Preprint]. 2025 Mar 4:2025.02.27.640335. doi: 10.1101/2025.02.27.640335. PubMed |
| CRISPR screening reveals ZNF217 as a vulnerability in high-risk B-cell acute lymphoblastic leukemia. Qin X, Zhou K, Dong L, Yang L, Li W, Chen Z, Shen C, Han L, Li Y, Chan AKN, Pokharel SP, Qing Y, Chen M, Wang K, Leung K, Sau L, Chen CW, Deng X, Su R, Chen J. Theranostics. 2025 Feb 18;15(8):3234-3256. doi: 10.7150/thno.100295. eCollection 2025. PubMed |
| Ubiquitination of gasdermin D N-terminal domain directs its membrane translocation and pore formation during pyroptosis. Chu X, Zhang T, Bukhari I, Hu M, Xu J, Xing Y, Liang X, Zhang Z, Zheng P. Cell Death Dis. 2025 Mar 17;16(1):181. doi: 10.1038/s41419-025-07475-6. PubMed |
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| CRISPR screens with trastuzumab emtansine in HER2-positive breast cancer cell lines reveal new insights into drug resistance. Lipert BA, Siemens KN, Khan A, Airey R, Dam GH, Lu M, Flinterman M, Yong Q, Lee TW, Hunter FW, Jamieson SMF. Breast Cancer Res. 2025 Mar 31;27(1):48. doi: 10.1186/s13058-025-02000-1. PubMed |
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EIF3D safeguards the homeostasis of key signaling pathways in human primed pluripotency.
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| ALDH1A3 Regulates Cellular Senescence and Senescence-Associated Secretome in Prostate Cancer. Wang S, Wang L, Zhao Y. Cancers (Basel). 2025 Mar 31;17(7):1184. doi: 10.3390/cancers17071184. PubMed |
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| Lysosomal lipid peroxidation contributes to ferroptosis induction via lysosomal membrane permeabilization. Saimoto Y, Kusakabe D, Morimoto K, Matsuoka Y, Kozakura E, Kato N, Tsunematsu K, Umeno T, Kiyotani T, Matsumoto S, Tsuji M, Hirayama T, Nagasawa H, Uchida K, Karasawa S, Jutanom M, Yamada KI. Nat Commun. 2025 Apr 15;16(1):3554. doi: 10.1038/s41467-025-58909-w. PubMed |
| Pan-cancer analysis of CHRDL1 expression and its mechanistic role in inhibiting EMT via the TGF-beta pathway in lung adenocarcinoma. Dong H, Tian Y, Xin S, Guo Y, Jiang S, Wan Z, Wang H, Han Y. Front Cell Dev Biol. 2025 Mar 31;13:1557761. doi: 10.3389/fcell.2025.1557761. eCollection 2025. PubMed |
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| Unraveling the Role of NeuroD2 in Ischemic Pathophysiology: Insight into Neuroprotection Mechanisms Associated with AKT Survival Kinase. Bolat B, Bayraktaroglu C, Degirmenci Z, Cerah E, Sali M, Kolcu E, Bars DN, Aydin C, Abasova F, Alisoy A, Atali HE, Beker MC, Celik U, Beker M. Neuromolecular Med. 2025 Apr 16;27(1):28. doi: 10.1007/s12017-025-08852-2. PubMed |
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| Comparative single-cell transcriptomic profiling of patient-derived renal carcinoma cells in cellular and animal models of kidney cancer. Huang R, Kee L, Gont A, Meens J, Ferens FG, Irwin MS, Ailles L, Yuzwa SA, Robinson CM, Ohh M. FEBS Open Bio. 2025 Apr 16. doi: 10.1002/2211-5463.70022. PubMed |
| The G protein-coupled receptor GPR89A is a novel potential therapeutic target to overcome cisplatin resistance in NSCLC Calu1 cells. Guler Kara H, Dogan E, Bozok V, Aktan C, Cakiroglu E, Eroglu Z, Aygunes Jafari D, Korkmaz KS, Senturk S, Kosova B. FEBS J. 2025 Jul;292(14):3755-3770. doi: 10.1111/febs.70099. Epub 2025 Apr 17. PubMed |
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Far-red chemigenetic kinase biosensors enable multiplexed and super-resolved imaging of signaling networks.
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| Metastatic medulloblastoma remodels the local leptomeningeal microenvironment to promote further metastatic colonization and growth. Abeysundara N, Rasnitsyn A, Fong V, Bahcheli A, Van Ommeren R, Juraschka K, Vladoiu M, Ong W, Livingston B, de Antonellis P, Ly M, Holgado BL, Sirbu O, Bahrampour S, Min HK, Fan J, Nor C, Visvanathan A, Zhang J, Wang H, Qin L, Huang N, Pallotta J, Douglas T, Mak E, Su H, Ng K, Zhang KY, Daniels C, Lucas CG, Eberhart CG, Liu H, Jiang T, Notta F, Ramaswamy V, Reimand J, Gallo M, Rich JN, Wu X, Huang X, Taylor MD. Nat Cell Biol. 2025 May;27(5):863-874. doi: 10.1038/s41556-025-01660-7. Epub 2025 Apr 22. PubMed |
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| IKAROS levels are associated with antigen escape in CD19- and CD22-targeted therapies for B-cell malignancies. Domizi P, Sarno J, Jager A, Merchant M, Pacheco KZB, Yamada-Hunter SA, Rotiroti MC, Liu Y, Baskar R, Reynolds WD, Sworder BJ, Sahaf B, Bendall SC, Mullighan CG, Alizadeh AA, Leahy AB, Myers RM, Yates B, Wang HW, Shah NN, Majzner RG, Mackall CL, Grupp SA, Barrett DM, Sotillo E, Davis KL. Nat Commun. 2025 Apr 23;16(1):3800. doi: 10.1038/s41467-025-58868-2. PubMed |
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| The Role of the Hexosamine-Sialic Acid Metabolic Pathway Mediated by GFPT1/NANS in c-Myc-Driven Hepatocellular Carcinoma. Wang S, Han P, Mi P, Wang C, Lu M, Li X, Xu B, Wang H, Gao Y, Hou Y, Tan X, Liang J, Ding X, Zhang Y, Zhang T, Yuan D, Gao L, Zhang C. Cell Mol Gastroenterol Hepatol. 2025 Apr 24;19(9):101523. doi: 10.1016/j.jcmgh.2025.101523. PubMed |
| Single influenza A viruses induce nanoscale cellular reprogramming at the virus-cell interface. Broich L, Wullenkord H, Osman MK, Fu Y, Musken M, Reuther P, Bronstrup M, Sieben C. Nat Commun. 2025 Apr 25;16(1):3846. doi: 10.1038/s41467-025-58935-8. PubMed |
| Ephrin B1 and B2 Mediate Cedar Virus Entry into Egyptian Fruit Bat Cells. Lenhard L, Muller M, Diederich S, Loerzer L, Friedrichs V, Kollner B, Finke S, Dorhoi A, Pei G. Viruses. 2025 Apr 16;17(4):573. doi: 10.3390/v17040573. PubMed |
| Targeted protein degraders of SARS-CoV-2 Mpro are more active than enzymatic inhibition alone with activity against nirmatrelvir resistant virus. Pan B, Mountford SJ, Kiso M, Anderson DE, Papadakis G, Jarman KE, Tilmanis DR, Maher B, Tran T, Shortt J, Yamayoshi S, Kawaoka Y, Thompson PE, Greenall SA, Warner N. Commun Med (Lond). 2025 Apr 26;5(1):140. doi: 10.1038/s43856-025-00863-1. PubMed |
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| Modulation of RASD2 by miRNA-485-5p Drives Thyroid Cancer Progression and Metastasis. Li XY, Sun JP, Guo H, Fan XQ, Zhang SS, Wang B, Yu N, Li QH. Kaohsiung J Med Sci. 2025 Jun;41(6):e70028. doi: 10.1002/kjm2.70028. Epub 2025 Apr 28. PubMed |
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| Dynamic activation of rAAV transgene expression by a small molecule that recruits endogenous transcriptional machinery. Wasserman SR, Muron S, Lee HR, Routh ML, Hepperla AJ, Scoville DM, Huber A, Umana JD, Pereira NE, Foley CA, James LI, Hathaway NA. Nucleic Acids Res. 2025 Apr 22;53(8):gkaf345. doi: 10.1093/nar/gkaf345. PubMed |
| Efficient Generation of Megakaryocyte Progenitors and Platelets From HSPCs via JAK2/STAT3 Signaling. Liu H, Wang L, Liu J, Yuan H, Zhang K, Qiu Y, Zhu F. Adv Sci (Weinh). 2025 Jun;12(23):e2500612. doi: 10.1002/advs.202500612. Epub 2025 Apr 29. PubMed |
| A multi-strategy antimicrobial discovery approach reveals new ways to treat Chlamydia. Olander M, Rea Vazquez D, Meier K, Singh A, Silva de Sousa A, Puertolas-Balint F, Milivojevic M, Mooij L, Fredlund J, Calpe Bosch E, Rayon Diaz M, Lundgren M, van der Wal K, Zhu S, Mateus A, Schroeder BO, Lohman JR, Sixt BS. PLoS Biol. 2025 Apr 29;23(4):e3003123. doi: 10.1371/journal.pbio.3003123. eCollection 2025 Apr. PubMed |
Model-guided design of microRNA-based gene circuits supports precise dosage of transgenic cargoes into diverse primary cells.
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| SNX17 mediates STAT3 activation to promote hepatocellular carcinoma progression via a retromer dependent mechanism. Liu Y, Tian W, Ge C, Zhang C, Huang Z, Zhang C, Yang Y, Tian H. Int J Biol Sci. 2025 Mar 31;21(6):2762-2779. doi: 10.7150/ijbs.110506. eCollection 2025. PubMed |
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| The suppressive role of GLS in radiosensitivity and irradiation-induced immune response in LUAD: integrating bioinformatics and experimental insights. Jiang P, Jiang Z, Li S, Li YX, Chen Y, Li X. Front Immunol. 2025 Apr 16;16:1582587. doi: 10.3389/fimmu.2025.1582587. eCollection 2025. PubMed |
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| FLT4 activation promotes acute lymphoid leukemia survival through stabilization of MDM2/MDMX and inactivation of p53. Haferssas D, Dubuissez M, Barrera-Chimal J, Messmer C, Affar EB, Larrivee B, Liu XS, Gerarduzzi C. Oncogenesis. 2025 May 2;14(1):14. doi: 10.1038/s41389-025-00552-7. PubMed |
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| Key Connectomes and Synaptic-Compartment-Specific Risk Genes Drive Pathological alpha-Synuclein Spreading. Li Y, Torok J, Zhang S, Ding J, Wang N, Lau C, Kulkarni S, Anand C, Tran J, Cheng M, Lo C, Lu B, Sun Y, Damoiseaux R, Yang X, Raj A, Peng C. Adv Sci (Weinh). 2025 Jul;12(25):e2413052. doi: 10.1002/advs.202413052. Epub 2025 May 28. PubMed |
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| Repurposing MDM2 inhibitor RG7388 for TP53-mutant NSCLC: a p53-independent pyroptotic mechanism via ROS/p-p38/NOXA/caspase-3/GSDME axis. Tang G, Cao X, Chen J, Hui F, Xu N, Jiang Y, Lu H, Xiao H, Liang X, Ma M, Qian Y, Liu D, Wang Z, Liu S, Yu G, Sun L. Cell Death Dis. 2025 Jun 17;16(1):452. doi: 10.1038/s41419-025-07770-2. PubMed |
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High-content image-based pooled screens reveal regulators of synaptogenesis.
Le A, Biederer T, Blainey PC.
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PubMed
Associated Plasmids |
| De novo assembly of RNA m(6)A modification factors into viral genome-associated nuclear bodies drives HCMV RNA accumulation. Grande RC, Lin CC, Cammer M, Emesom ED, Khurram MA, Boutell C, Denes LT, Lionnet T, Wilson AC, Mohr I. Cell Rep. 2025 Jul 22;44(7):115826. doi: 10.1016/j.celrep.2025.115826. Epub 2025 Jun 24. PubMed |
| RIPK1 senses S-adenosylmethionine scarcity to drive cell death and inflammation. Chen Z, Gu X, Chen H, Zhang H, Liu J, Yang X, Cai Y, Zhang M, Yan L, Yang Y, Shan B, Zhu ZJ, Zhang Y, Gu J, Xu D. Cell Metab. 2025 Aug 5;37(8):1732-1749.e9. doi: 10.1016/j.cmet.2025.05.014. Epub 2025 Jun 25. PubMed |
| Phenotypic screens for SIRPA expression reveal RAB21 as a general regulator of macrophage surface identity. Granda Farias A, Feng B, Khan S, Ngo W, Wu JLY, Aguilera-Uribe M, Grewal S, Mero P, Singh SK, Kislinger T, Chan WCW, Moffat J. Cell Rep. 2025 Jul 22;44(7):115921. doi: 10.1016/j.celrep.2025.115921. Epub 2025 Jun 27. PubMed |
| Tailoring a novel colorectal cancer stem cell-targeted therapy by inhibiting the SMYD3/c-MYC axis. Lepore Signorile M, Di Nicola E, Forte G, Sanese P, Fasano C, Disciglio V, De Marco K, Latrofa M, De Cecco L, Ficorilli M, Lucchetta M, Torchia E, Dossena C, Bianco G, Spilotro V, Ferroni C, Labarile N, Armentano R, Albano F, Mestice A, Gigante G, Lantone V, Lantone G, Vincenti L, Del Rio A, Varchi G, Grossi V, Simone C. Signal Transduct Target Ther. 2025 Jun 30;10(1):206. doi: 10.1038/s41392-025-02290-z. PubMed |
| Klf5-adjacent super-enhancer functions as a 3D genome structure-dependent transcriptional driver to safeguard ESC identity. Su G, Chen B, Song Y, Yin Q, Wang W, Zhao X, Fan S, Lian J, Li D, Bi J, Li P, Zhao Z, Zhang L, Shi J, Lu W. Nat Commun. 2025 Jul 1;16(1):5540. doi: 10.1038/s41467-025-60389-x. PubMed |
| Spatially resolved C1QC(+) macrophage-CD4(+) T cell niche in colorectal cancer microenvironment: implications for immunotherapy response. Zhang H, Hong L, Dong Z, Xin S, Lin B, Cheng J, Tian W, Li B, Wang J, Liu X, Liu C, Jin Y, Feng Y, Su G, Sun X, Liu Q, Dai X, Gao Y, Tong Z, Liu L, Zhu X, Zheng Y, Zhao P, Guo T, Fang W, Bao X. Cell Discov. 2025 Jul 1;11(1):60. doi: 10.1038/s41421-025-00811-2. PubMed |
| p62 mRNA suppresses NLRP1 expression in cutaneous SCC cells through miR-34a-5p. Hennig P, Turko P, Di Filippo M, Levesque MP, Kundig T, Beer HD. Cell Death Dis. 2025 Jul 1;16(1):465. doi: 10.1038/s41419-025-07785-9. PubMed |
| CFAP100 couples microtubule glutamylation to spindle pole integrity in keratinocytes to promote epidermal development. Sun S, Wang Z, Xu Z, Wang Z, Sun J, Li K, Liu M, Zhao H, Liu P, Zhou J. Nat Commun. 2025 Jul 1;16(1):5591. doi: 10.1038/s41467-025-60677-6. PubMed |
| Legionella pneumophila modulates the host cytoskeleton by an effector of transglutaminase activity. Liu Y, Liu Y, Luo ZQ. mLife. 2025 Jun 18;4(3):232-248. doi: 10.1002/mlf2.70013. eCollection 2025 Jun. PubMed |
| Enhancing CAR-T Cell Metabolic Fitness and Memory Phenotype for Improved Efficacy against Hepatocellular Carcinoma. You J, Yang X, Zhao J, Chen H, Tang Y, Ouyang D, Liu Y, Wang Y, Xie S, Chen Y, Liao J, Xiang T, Xia J, Yang C, Weng D. Int J Biol Sci. 2025 Jun 20;21(9):4231-4251. doi: 10.7150/ijbs.110406. eCollection 2025. PubMed |
| Coupling of glucose metabolism with mitophagy via O-GlcNAcylation of PINK1. Xu Z, Gao X, Rong D, Wang J, Gao L, Tang M, Chen Y, Zhang Y, Xie L, Wang L, Lu G, Lu JH, Liu W, Shen HM. Int J Biol Sci. 2025 Jun 20;21(9):4252-4269. doi: 10.7150/ijbs.112672. eCollection 2025. PubMed |
| WNT5B regulates myogenesis and fiber type conversion by affecting mRNA stability. Fan D, Yao Y, Yan C, Li F, Yang Y, Xie B, Tang Z. Int J Biol Sci. 2025 Jun 9;21(9):3934-3948. doi: 10.7150/ijbs.102309. eCollection 2025. PubMed |
| Various anthracyclines exhibit differential cytotoxic effects related to CBR1-induced resistance in lung cancer cells. Piska K, Koczurkiewicz-Adamczyk P, Kochanowski P, Bobis-Wozowicz S, Wladyka B, Pekala E. Med Oncol. 2025 Jul 8;42(8):315. doi: 10.1007/s12032-025-02893-0. PubMed |
| RBM14 enhances transcriptional activity of p23 regulating CXCL1 expression to induce lung cancer metastasis. Zhang W, Peng Y, Zhou M, Qian L, Che Y, Chen J, Zhang W, He C, Qi M, Shu X, Tian M, Tian X, Tian Y, Deng S, Wang Y, Huo X, Yu Z, Ma X. Acta Pharm Sin B. 2025 Jun;15(6):3059-3072. doi: 10.1016/j.apsb.2025.03.048. Epub 2025 Apr 4. PubMed |
A proximity-labeling-based approach to directly detect mRNA delivery to specific subcellular locations.
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PubMed
Associated Plasmids |
| METTL3-mediated m(6)A methylation of lncRNA PVT1 promotes the progression of oral squamous cell carcinoma via the miR-185-5p/SERPINB4 axis. Chen C, Li J, Yang B, Kong L, Zhang D, Guo J, Zhou L, Bai G, Zhao H, Meng Z. Am J Cancer Res. 2025 Jun 25;15(6):2872-2889. doi: 10.62347/HERV8396. eCollection 2025. PubMed |
| Expression of DNAJB1-PRKACA oncogene suppresses the differentiation potential of liver progenitor organoids towards a hepatocyte lineage. DiPietro E, Bharath N, Karski M, Durfee O, Sherman MS, Ma Q, Sun L, Farghli AR, Smith CJ, Kycia I, Sethupathy P, Goessling W, Rogers MS, Vakili K. Sci Rep. 2025 Jul 16;15(1):25796. doi: 10.1038/s41598-025-11028-4. PubMed |
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