psPAX2 Citations (6332)
Originally described in: Trono Lab Packaging and Envelope PlasmidsUnpublished
Articles Citing psPAX2
| Articles |
|---|
| New cell lines from mouse epiblast share defining features with human embryonic stem cells. Tesar PJ, Chenoweth JG, Brook FA, Davies TJ, Evans EP, Mack DL, Gardner RL, McKay RD. Nature. 2007 Jul 12. 448(7150):196-9. PubMed |
| CCL2 protects prostate cancer PC3 cells from autophagic death via phosphatidylinositol 3-kinase/AKT-dependent survivin up-regulation. Roca H, Varsos Z, Pienta KJ. J Biol Chem. 2008 Sep 5;283(36):25057-73. doi: 10.1074/jbc.M801073200. Epub 2008 Jul 8. PubMed |
| A polypyrimidine tract-binding protein-dependent pathway of mRNA stability initiates with CpG activation of primary B cells. Porter JF, Vavassori S, Covey LR. J Immunol. 2008 Sep 1;181(5):3336-45. PubMed |
| Feeder-free culture of human embryonic stem cells in conditioned medium for efficient genetic modification. Braam SR, Denning C, Matsa E, Young LE, Passier R, Mummery CL. Nat Protoc. 2008;3(9):1435-43. doi: 10.1038/nprot.2008.140. PubMed |
| The scaffold protein JSAP1 regulates proliferation and differentiation of cerebellar granule cell precursors by modulating JNK signaling. Sato T, Torashima T, Sugihara K, Hirai H, Asano M, Yoshioka K. Mol Cell Neurosci. 2008 Dec;39(4):569-78. doi: 10.1016/j.mcn.2008.08.003. Epub 2008 Aug 30. PubMed |
| Functional involvement of RINF, retinoid-inducible nuclear factor (CXXC5), in normal and tumoral human myelopoiesis. Pendino F, Nguyen E, Jonassen I, Dysvik B, Azouz A, Lanotte M, Segal-Bendirdjian E, Lillehaug JR. Blood. 2009 Apr 2;113(14):3172-81. doi: 10.1182/blood-2008-07-170035. Epub 2009 Jan 30. PubMed |
| A functional genomic screen identifies cellular cofactors of hepatitis C virus replication. Tai AW, Benita Y, Peng LF, Kim SS, Sakamoto N, Xavier RJ, Chung RT. Cell Host Microbe. 2009 Mar 19;5(3):298-307. doi: 10.1016/j.chom.2009.02.001. PubMed |
| Matrix metalloproteinase 12 silencing: a therapeutic approach to treat pathological lung tissue remodeling? Garbacki N, Di Valentin E, Piette J, Cataldo D, Crahay C, Colige A. Pulm Pharmacol Ther. 2009 Aug;22(4):267-78. doi: 10.1016/j.pupt.2009.03.001. Epub 2009 Mar 25. PubMed |
| TNFAIP3 (A20) is a tumor suppressor gene in Hodgkin lymphoma and primary mediastinal B cell lymphoma. Schmitz R, Hansmann ML, Bohle V, Martin-Subero JI, Hartmann S, Mechtersheimer G, Klapper W, Vater I, Giefing M, Gesk S, Stanelle J, Siebert R, Kuppers R. J Exp Med. 2009 May 11;206(5):981-9. doi: 10.1084/jem.20090528. Epub 2009 Apr 20. PubMed |
| Tumor microvasculature supports proliferation and expansion of glioma-propagating cells. Borovski T, Verhoeff JJ, ten Cate R, Cameron K, de Vries NA, van Tellingen O, Richel DJ, van Furth WR, Medema JP, Sprick MR. Int J Cancer. 2009 Sep 1;125(5):1222-30. doi: 10.1002/ijc.24408. PubMed |
| Tubulin polymerization-promoting protein (TPPP/p25) is critical for oligodendrocyte differentiation. Lehotzky A, Lau P, Tokesi N, Muja N, Hudson LD, Ovadi J. Glia. 2010 Jan 15;58(2):157-68. doi: 10.1002/glia.20909. PubMed |
| Long term non-invasive imaging of embryonic stem cells using reporter genes. Sun N, Lee A, Wu JC. Nat Protoc. 2009;4(8):1192-201. doi: 10.1038/nprot.2009.100. Epub 2009 Jul 23. PubMed |
| Multipurpose modular lentiviral vectors for RNA interference and transgene expression. Kesireddy V, van der Ven PF, Furst DO. Mol Biol Rep. 2010 Jul;37(6):2863-70. doi: 10.1007/s11033-009-9840-8. Epub 2009 Oct 2. PubMed |
| Photostimulation of channelrhodopsin-2 expressing ventrolateral medullary neurons increases sympathetic nerve activity and blood pressure in rats. Abbott SB, Stornetta RL, Socolovsky CS, West GH, Guyenet PG. J Physiol. 2009 Dec 1. 587(Pt 23):5613-31. PubMed |
| Inducible APOBEC3G-Vif double stable cell line as a high-throughput screening platform to identify antiviral compounds. Nowotny B, Schneider T, Pradel G, Schirmeister T, Rethwilm A, Kirschner M. Antimicrob Agents Chemother. 2010 Jan;54(1):78-87. doi: 10.1128/AAC.00775-09. Epub 2009 Oct 19. PubMed |
| Transcription factors RUNX1 and RUNX3 in the induction and suppressive function of Foxp3+ inducible regulatory T cells. Klunker S, Chong MM, Mantel PY, Palomares O, Bassin C, Ziegler M, Ruckert B, Meiler F, Akdis M, Littman DR, Akdis CA. J Exp Med. 2009 Nov 23;206(12):2701-15. doi: 10.1084/jem.20090596. Epub 2009 Nov 16. PubMed |
| Neural stem cells as a novel platform for tumor-specific delivery of therapeutic antibodies. Frank RT, Edmiston M, Kendall SE, Najbauer J, Cheung CW, Kassa T, Metz MZ, Kim SU, Glackin CA, Wu AM, Yazaki PJ, Aboody KS. PLoS One. 2009 Dec 15;4(12):e8314. doi: 10.1371/journal.pone.0008314. PubMed |
| Lentiviral gene transduction in human and mouse NK cell lines. Savan R, Chan T, Young HA. Methods Mol Biol. 2010;612:209-21. doi: 10.1007/978-1-60761-362-6_14. PubMed |
| HEF1 is a crucial mediator of the proliferative effects of prostaglandin E(2) on colon cancer cells. Xia D, Holla VR, Wang D, Menter DG, DuBois RN. Cancer Res. 2010 Jan 15;70(2):824-31. doi: 10.1158/0008-5472.CAN-09-2105. Epub 2010 Jan 12. PubMed |
| An inducible Tet-Off-H2B-GFP lentiviral reporter vector for detection and in vivo isolation of label-retaining cells. Falkowska-Hansen B, Kollar J, Gruner BM, Schanz M, Boukamp P, Siveke J, Rethwilm A, Kirschner M. Exp Cell Res. 2010 Jul 1;316(11):1885-95. doi: 10.1016/j.yexcr.2010.02.015. Epub 2010 Feb 18. PubMed |
| Tumor necrosis factor receptor superfamily member 19 (TNFRSF19) regulates differentiation fate of human mesenchymal (stromal) stem cells through canonical Wnt signaling and C/EBP. Qiu W, Hu Y, Andersen TE, Jafari A, Li N, Chen W, Kassem M. J Biol Chem. 2010 May 7;285(19):14438-49. doi: 10.1074/jbc.M109.052001. Epub 2010 Mar 11. PubMed |
| Lentiviral vector-mediated transgenesis in human embryonic stem cells. Du ZW, Zhang SC. Methods Mol Biol. 2010;614:127-34. doi: 10.1007/978-1-60761-533-0_8. PubMed |
| Aire regulates the expression of differentiation-associated genes and self-renewal of embryonic stem cells. Gu B, Zhang J, Chen Q, Tao B, Wang W, Zhou Y, Chen L, Liu Y, Zhang M. Biochem Biophys Res Commun. 2010 Apr 2. 394(2):418-23. PubMed |
| Functional analysis of the Cdk7.cyclin H.Mat1 complex in mouse embryonic stem cells and embryos. Patel SA, Simon MC. J Biol Chem. 2010 May 14;285(20):15587-98. doi: 10.1074/jbc.M109.081687. Epub 2010 Mar 15. PubMed |
| Differential splicing of the apoptosis-associated speck like protein containing a caspase recruitment domain (ASC) regulates inflammasomes. Bryan NB, Dorfleutner A, Kramer SJ, Yun C, Rojanasakul Y, Stehlik C. J Inflamm (Lond). 2010 May 18;7:23. doi: 10.1186/1476-9255-7-23. PubMed |
| Transmembrane protein 147 (TMEM147) is a novel component of the Nicalin-NOMO protein complex. Dettmer U, Kuhn PH, Abou-Ajram C, Lichtenthaler SF, Kruger M, Kremmer E, Haass C, Haffner C. J Biol Chem. 2010 Aug 20;285(34):26174-81. doi: 10.1074/jbc.M110.132548. Epub 2010 Jun 10. PubMed |
| A novel, retromer-independent role for sorting nexins 1 and 2 in RhoG-dependent membrane remodeling. Prosser DC, Tran D, Schooley A, Wendland B, Ngsee JK. Traffic. 2010 Oct;11(10):1347-62. doi: 10.1111/j.1600-0854.2010.01100.x. PubMed |
| Two functionally distinct isoforms of TL1A (TNFSF15) generated by differential ectodomain shedding. Muck C, Herndler-Brandstetter D, Micutkova L, Grubeck-Loebenstein B, Jansen-Durr P. J Gerontol A Biol Sci Med Sci. 2010 Nov;65(11):1165-80. doi: 10.1093/gerona/glq129. Epub 2010 Jul 30. PubMed |
| Expression of miR-33 from an SREBP2 intron inhibits cholesterol export and fatty acid oxidation. Gerin I, Clerbaux LA, Haumont O, Lanthier N, Das AK, Burant CF, Leclercq IA, MacDougald OA, Bommer GT. J Biol Chem. 2010 Oct 29;285(44):33652-61. doi: 10.1074/jbc.M110.152090. Epub 2010 Aug 22. PubMed |
| Stable overexpression of miRNAs in bone marrow-derived murine mast cells using lentiviral expression vectors. Mayoral RJ, Monticelli S. Methods Mol Biol. 2010;667:205-14. doi: 10.1007/978-1-60761-811-9_14. PubMed |
| Incremental genetic perturbations to MCM2-7 expression and subcellular distribution reveal exquisite sensitivity of mice to DNA replication stress. Chuang CH, Wallace MD, Abratte C, Southard T, Schimenti JC. PLoS Genet. 2010 Sep 9;6(9):e1001110. doi: 10.1371/journal.pgen.1001110. PubMed |
| Syntaxin 3 is necessary for cAMP- and cGMP-regulated exocytosis of CFTR: implications for enterotoxigenic diarrhea. Collaco A, Marathe J, Kohnke H, Kravstov D, Ameen N. Am J Physiol Cell Physiol. 2010 Dec;299(6):C1450-60. doi: 10.1152/ajpcell.00029.2010. Epub 2010 Sep 15. PubMed |
| Role for PKC delta in Fenretinide-Mediated Apoptosis in Lymphoid Leukemia Cells. Ruvolo VR, Karanjeet KB, Schuster TF, Brown R, Deng Y, Hinchcliffe E, Ruvolo PP. J Signal Transduct. 2010 Jan 1;2010:584657. PubMed |
| Effects of estrogen on the proportion of stem cells in the breast. Simoes BM, Piva M, Iriondo O, Comaills V, Lopez-Ruiz JA, Zabalza I, Mieza JA, Acinas O, Vivanco MD. Breast Cancer Res Treat. 2011 Aug;129(1):23-35. doi: 10.1007/s10549-010-1169-4. Epub 2010 Sep 22. PubMed |
| ATR and ATRIP are recruited to herpes simplex virus type 1 replication compartments even though ATR signaling is disabled. Mohni KN, Livingston CM, Cortez D, Weller SK. J Virol. 2010 Dec;84(23):12152-64. doi: 10.1128/JVI.01643-10. Epub 2010 Sep 22. PubMed |
| Dual selection mechanisms drive efficient single-gene reverse genetics for rotavirus. Trask SD, Taraporewala ZF, Boehme KW, Dermody TS, Patton JT. Proc Natl Acad Sci U S A. 2010 Oct 26;107(43):18652-7. doi: 10.1073/pnas.1011948107. Epub 2010 Oct 11. PubMed |
| The SR-BI partner PDZK1 facilitates hepatitis C virus entry. Eyre NS, Drummer HE, Beard MR. PLoS Pathog. 2010 Oct 7;6(10):e1001130. doi: 10.1371/journal.ppat.1001130. PubMed |
| Silencing of CDK5 reduces neurofibrillary tangles in transgenic alzheimer's mice. Piedrahita D, Hernandez I, Lopez-Tobon A, Fedorov D, Obara B, Manjunath BS, Boudreau RL, Davidson B, Laferla F, Gallego-Gomez JC, Kosik KS, Cardona-Gomez GP. J Neurosci. 2010 Oct 20;30(42):13966-76. doi: 10.1523/JNEUROSCI.3637-10.2010. PubMed |
Large intergenic non-coding RNA-RoR modulates reprogramming of human induced pluripotent stem cells.
Loewer S, Cabili MN, Guttman M, Loh YH, Thomas K, Park IH, Garber M, Curran M, Onder T, Agarwal S, Manos PD, Datta S, Lander ES, Schlaeger TM, Daley GQ, Rinn JL.
Nat Genet. 2010 Dec;42(12):1113-7. Epub 2010 Nov 7.
PubMed
Associated Plasmids |
| The TRAF-interacting protein (TRIP) is a regulator of keratinocyte proliferation. Almeida S, Ryser S, Obarzanek-Fojt M, Hohl D, Huber M. J Invest Dermatol. 2011 Feb;131(2):349-57. doi: 10.1038/jid.2010.329. Epub 2010 Nov 11. PubMed |
| Prolylcarboxypeptidase regulates proliferation, autophagy, and resistance to 4-hydroxytamoxifen-induced cytotoxicity in estrogen receptor-positive breast cancer cells. Duan L, Motchoulski N, Danzer B, Davidovich I, Shariat-Madar Z, Levenson VV. J Biol Chem. 2011 Jan 28;286(4):2864-76. doi: 10.1074/jbc.M110.143271. Epub 2010 Nov 17. PubMed |
| Polypyrimidine tract-binding protein is critical for the turnover and subcellular distribution of CD40 ligand mRNA in CD4+ T cells. Matus-Nicodemos R, Vavassori S, Castro-Faix M, Valentin-Acevedo A, Singh K, Marcelli V, Covey LR. J Immunol. 2011 Feb 15;186(4):2164-71. doi: 10.4049/jimmunol.1003236. Epub 2011 Jan 17. PubMed |
| Akt1 deletion prevents lung tumorigenesis by mutant K-ras. Hollander MC, Maier CR, Hobbs EA, Ashmore AR, Linnoila RI, Dennis PA. Oncogene. 2011 Apr 14;30(15):1812-21. doi: 10.1038/onc.2010.556. Epub 2011 Jan 17. PubMed |
| Senescence-associated heterochromatin foci are dispensable for cellular senescence, occur in a cell type- and insult-dependent manner and follow expression of p16(ink4a). Kosar M, Bartkova J, Hubackova S, Hodny Z, Lukas J, Bartek J. Cell Cycle. 2011 Feb 1;10(3):457-68. Epub 2011 Feb 1. PubMed |
| Yes-associated protein (YAP) transcriptional coactivator functions in balancing growth and differentiation in skin. Zhang H, Pasolli HA, Fuchs E. Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2270-5. doi: 10.1073/pnas.1019603108. Epub 2011 Jan 24. PubMed |
| JNK signaling promotes intestinal tumorigenesis through activation of mTOR complex 1 in Apc(Delta716) mice. Fujishita T, Aoki M, Taketo MM. Gastroenterology. 2011 May;140(5):1556-63.e6. doi: 10.1053/j.gastro.2011.02.007. Epub 2011 Feb 12. PubMed |
| High-throughput screening of microscale pitted substrate topographies for enhanced nonviral transfection efficiency in primary human fibroblasts. Adler AF, Speidel AT, Christoforou N, Kolind K, Foss M, Leong KW. Biomaterials. 2011 May;32(14):3611-9. doi: 10.1016/j.biomaterials.2011.01.040. Epub 2011 Feb 21. PubMed |
| Recapitulation of premature ageing with iPSCs from Hutchinson-Gilford progeria syndrome. Liu GH, Barkho BZ, Ruiz S, Diep D, Qu J, Yang SL, Panopoulos AD, Suzuki K, Kurian L, Walsh C, Thompson J, Boue S, Fung HL, Sancho-Martinez I, Zhang K, Yates J 3rd, Izpisua Belmonte JC. Nature. 2011 Apr 14;472(7342):221-5. doi: 10.1038/nature09879. Epub 2011 Feb 23. PubMed |
| The neuronal differentiation factor NeuroD1 downregulates the neuronal repellent factor Slit2 expression and promotes cell motility and tumor formation of neuroblastoma. Huang P, Kishida S, Cao D, Murakami-Tonami Y, Mu P, Nakaguro M, Koide N, Takeuchi I, Onishi A, Kadomatsu K. Cancer Res. 2011 Apr 15;71(8):2938-48. doi: 10.1158/0008-5472.CAN-10-3524. Epub 2011 Feb 24. PubMed |
| SirT3 suppresses hypoxia inducible factor 1alpha and tumor growth by inhibiting mitochondrial ROS production. Bell EL, Emerling BM, Ricoult SJ, Guarente L. Oncogene. 2011 Jun 30;30(26):2986-96. doi: 10.1038/onc.2011.37. Epub 2011 Feb 28. PubMed |
| Somatic coding mutations in human induced pluripotent stem cells. Gore A, Li Z, Fung HL, Young JE, Agarwal S, Antosiewicz-Bourget J, Canto I, Giorgetti A, Israel MA, Kiskinis E, Lee JH, Loh YH, Manos PD, Montserrat N, Panopoulos AD, Ruiz S, Wilbert ML, Yu J, Kirkness EF, Izpisua Belmonte JC, Rossi DJ, Thomson JA, Eggan K, Daley GQ, Goldstein LS, Zhang K. Nature. 2011 Mar 3;471(7336):63-7. doi: 10.1038/nature09805. PubMed |
| S1P lyase regulates DNA damage responses through a novel sphingolipid feedback mechanism. Kumar A, Oskouian B, Fyrst H, Zhang M, Paris F, Saba JD. Cell Death Dis. 2011 Feb 10;2:e119. doi: 10.1038/cddis.2011.3. PubMed |
| Lentiviral vector mediated modification of mesenchymal stem cells & enhanced survival in an in vitro model of ischaemia. McGinley L, McMahon J, Strappe P, Barry F, Murphy M, O'Toole D, O'Brien T. Stem Cell Res Ther. 2011 Mar 7;2(2):12. doi: 10.1186/scrt53. PubMed |
| Mutation and loss of expression of ARID1A in uterine low-grade endometrioid carcinoma. Guan B, Mao TL, Panuganti PK, Kuhn E, Kurman RJ, Maeda D, Chen E, Jeng YM, Wang TL, Shih IeM. Am J Surg Pathol. 2011 May;35(5):625-32. doi: 10.1097/PAS.0b013e318212782a. PubMed |
| Anthrax lethal factor activates K(+) channels to induce IL-1beta secretion in macrophages. Thomas J, Epshtein Y, Chopra A, Ordog B, Ghassemi M, Christman JW, Nattel S, Cook JL, Levitan I. J Immunol. 2011 May 1;186(9):5236-43. doi: 10.4049/jimmunol.1001078. Epub 2011 Mar 18. PubMed |
| Histone demethylase JMJD2B functions as a co-factor of estrogen receptor in breast cancer proliferation and mammary gland development. Kawazu M, Saso K, Tong KI, McQuire T, Goto K, Son DO, Wakeham A, Miyagishi M, Mak TW, Okada H. PLoS One. 2011 Mar 18;6(3):e17830. doi: 10.1371/journal.pone.0017830. PubMed |
| HIV infection enhances TRAIL-induced cell death in macrophage by down-regulating decoy receptor expression and generation of reactive oxygen species. Zhu DM, Shi J, Liu S, Liu Y, Zheng D. PLoS One. 2011 Apr 5;6(4):e18291. doi: 10.1371/journal.pone.0018291. PubMed |
| The NLR adaptor ASC/PYCARD regulates DUSP10, mitogen-activated protein kinase (MAPK), and chemokine induction independent of the inflammasome. Taxman DJ, Holley-Guthrie EA, Huang MT, Moore CB, Bergstralh DT, Allen IC, Lei Y, Gris D, Ting JP. J Biol Chem. 2011 Jun 3;286(22):19605-16. doi: 10.1074/jbc.M111.221077. Epub 2011 Apr 12. PubMed |
| Efficient preparation and labeling of human induced pluripotent stem cells by nanotechnology. Ruan J, Shen J, Wang Z, Ji J, Song H, Wang K, Liu B, Li J, Cui D. Int J Nanomedicine. 2011;6:425-35. doi: 10.2147/IJN.S16498. Epub 2011 Feb 21. PubMed |
| mTORC1 inhibition increases neurotensin secretion and gene expression through activation of the MEK/ERK/c-Jun pathway in the human endocrine cell line BON. Li J, Liu J, Song J, Wang X, Weiss HL, Townsend CM Jr, Gao T, Evers BM. Am J Physiol Cell Physiol. 2011 Jul;301(1):C213-26. doi: 10.1152/ajpcell.00067.2011. Epub 2011 Apr 20. PubMed |
| Human cytomegalovirus IE1 protein elicits a type II interferon-like host cell response that depends on activated STAT1 but not interferon-gamma. Knoblach T, Grandel B, Seiler J, Nevels M, Paulus C. PLoS Pathog. 2011 Apr;7(4):e1002016. doi: 10.1371/journal.ppat.1002016. Epub 2011 Apr 14. PubMed |
| The function of hypoxia-inducible factor (HIF) is independent of the endoplasmic reticulum protein OS-9. Brockmeier U, Platzek C, Schneider K, Patak P, Bernardini A, Fandrey J, Metzen E. PLoS One. 2011 Apr 29;6(4):e19151. doi: 10.1371/journal.pone.0019151. PubMed |
| Deptor knockdown enhances mTOR Activity and protein synthesis in myocytes and ameliorates disuse muscle atrophy. Kazi AA, Hong-Brown L, Lang SM, Lang CH. Mol Med. 2011 Sep-Oct;17(9-10):925-36. doi: 10.2119/molmed.2011.00070. Epub 2011 May 19. PubMed |
| Transforming growth factor beta controls CCN3 expression in nucleus pulposus cells of the intervertebral disc. Tran CM, Smith HE, Symes A, Rittie L, Perbal B, Shapiro IM, Risbud MV. Arthritis Rheum. 2011 Oct;63(10):3022-31. doi: 10.1002/art.30468. PubMed |
| Faster generation of hiPSCs by coupling high-titer lentivirus and column-based positive selection. Dick E, Matsa E, Young LE, Darling D, Denning C. Nat Protoc. 2011 Jun;6(6):701-14. doi: 10.1038/nprot.2011.320. Epub 2011 May 5. PubMed |
| GPM6B regulates osteoblast function and induction of mineralization by controlling cytoskeleton and matrix vesicle release. Drabek K, van de Peppel J, Eijken M, van Leeuwen JP. J Bone Miner Res. 2011 Sep;26(9):2045-51. doi: 10.1002/jbmr.435. PubMed |
| L-3-Phosphoserine phosphatase (PSPH) regulates cutaneous squamous cell carcinoma proliferation independent of L-serine biosynthesis. Bachelor MA, Lu Y, Owens DM. J Dermatol Sci. 2011 Sep;63(3):164-72. doi: 10.1016/j.jdermsci.2011.06.001. Epub 2011 Jun 22. PubMed |
| Hypoxia leads to Na,K-ATPase downregulation via Ca(2+) release-activated Ca(2+) channels and AMPK activation. Gusarova GA, Trejo HE, Dada LA, Briva A, Welch LC, Hamanaka RB, Mutlu GM, Chandel NS, Prakriya M, Sznajder JI. Mol Cell Biol. 2011 Sep;31(17):3546-56. doi: 10.1128/MCB.05114-11. Epub 2011 Jul 5. PubMed |
| Lentiviral-mediated knockdown during ex vivo erythropoiesis of human hematopoietic stem cells. Palii CG, Pasha R, Brand M. J Vis Exp. 2011 Jul 16;(53). pii: 2813. doi: 10.3791/2813. PubMed |
| Differentiation and neuro-protective properties of immortalized human tooth germ stem cells. Yalvac ME, Yilmaz A, Mercan D, Aydin S, Dogan A, Arslan A, Demir Z, Salafutdinov II, Shafigullina AK, Sahin F, Rizvanov AA, Palotas A. Neurochem Res. 2011 Dec;36(12):2227-35. doi: 10.1007/s11064-011-0546-7. Epub 2011 Jul 22. PubMed |
| Endothelial cells create a stem cell niche in glioblastoma by providing NOTCH ligands that nurture self-renewal of cancer stem-like cells. Zhu TS, Costello MA, Talsma CE, Flack CG, Crowley JG, Hamm LL, He X, Hervey-Jumper SL, Heth JA, Muraszko KM, DiMeco F, Vescovi AL, Fan X. Cancer Res. 2011 Sep 15;71(18):6061-72. doi: 10.1158/0008-5472.CAN-10-4269. Epub 2011 Jul 25. PubMed |
| Transduction of human cells with polymer-complexed ecotropic lentivirus for enhanced biosafety. Barrilleaux B, Knoepfler P. J Vis Exp. 2011 Jul 24;(53). pii: 2822. doi: 10.3791/2822. PubMed |
| Derivation of induced pluripotent stem cells by lentiviral transduction. Nethercott HE, Brick DJ, Schwartz PH. Methods Mol Biol. 2011;767:67-85. doi: 10.1007/978-1-61779-201-4_6. PubMed |
| CYP2S1 and CYP2W1 mediate 2-(3,4-dimethoxyphenyl)-5-fluorobenzothiazole (GW-610, NSC 721648) sensitivity in breast and colorectal cancer cells. Tan BS, Tiong KH, Muruhadas A, Randhawa N, Choo HL, Bradshaw TD, Stevens MF, Leong CO. Mol Cancer Ther. 2011 Oct;10(10):1982-92. doi: 10.1158/1535-7163.MCT-11-0391. Epub 2011 Aug 10. PubMed |
Effect of Ser-129 phosphorylation on interaction of alpha-synuclein with synaptic and cellular membranes.
Visanji NP, Wislet-Gendebien S, Oschipok LW, Zhang G, Aubert I, Fraser PE, Tandon A.
J Biol Chem. 2011 Oct 14;286(41):35863-73. Epub 2011 Aug 17.
PubMed
Associated Plasmids |
| Dickkopf-3 maintains the PANC-1 human pancreatic tumor cells in a dedifferentiated state. Zenzmaier C, Hermann M, Hengster P, Berger P. Int J Oncol. 2012 Jan;40(1):40-6. doi: 10.3892/ijo.2011.1180. Epub 2011 Aug 29. PubMed |
ARID1A, a factor that promotes formation of SWI/SNF-mediated chromatin remodeling, is a tumor suppressor in gynecologic cancers.
Guan B, Wang TL, Shih IeM.
Cancer Res. 2011 Nov 1;71(21):6718-27. Epub 2011 Sep 7.
PubMed
Associated Plasmids |
| Daedalus: a robust, turnkey platform for rapid production of decigram quantities of active recombinant proteins in human cell lines using novel lentiviral vectors. Bandaranayake AD, Correnti C, Ryu BY, Brault M, Strong RK, Rawlings DJ. Nucleic Acids Res. 2011 Nov;39(21):e143. doi: 10.1093/nar/gkr706. Epub 2011 Sep 12. PubMed |
| Modeling sarcomagenesis using multipotent mesenchymal stem cells. Rodriguez R, Rubio R, Menendez P. Cell Res. 2012 Jan;22(1):62-77. doi: 10.1038/cr.2011.157. Epub 2011 Sep 20. PubMed |
| Inhibition of mTOR kinase by AZD8055 can antagonize chemotherapy-induced cell death through autophagy induction and down-regulation of p62/sequestosome 1. Huang S, Yang ZJ, Yu C, Sinicrope FA. J Biol Chem. 2011 Nov 18;286(46):40002-12. doi: 10.1074/jbc.M111.297432. Epub 2011 Sep 23. PubMed |
| DNA mismatch repair proteins are required for efficient herpes simplex virus 1 replication. Mohni KN, Mastrocola AS, Bai P, Weller SK, Heinen CD. J Virol. 2011 Dec;85(23):12241-53. doi: 10.1128/JVI.05487-11. Epub 2011 Sep 28. PubMed |
| HIF-1alpha and HIF-2alpha degradation is differentially regulated in nucleus pulposus cells of the intervertebral disc. Fujita N, Chiba K, Shapiro IM, Risbud MV. J Bone Miner Res. 2012 Feb;27(2):401-12. doi: 10.1002/jbmr.538. PubMed |
| Suppression of BCL-2 synergizes cisplatin sensitivity in nasopharyngeal carcinoma cells. Low SY, Tan BS, Choo HL, Tiong KH, Khoo AS, Leong CO. Cancer Lett. 2012 Jan 28;314(2):166-75. doi: 10.1016/j.canlet.2011.09.025. Epub 2011 Oct 8. PubMed |
| Disruption of Wnt planar cell polarity signaling by aberrant accumulation of the MetAP-2 substrate Rab37. Sundberg TB, Darricarrere N, Cirone P, Li X, McDonald L, Mei X, Westlake CJ, Slusarski DC, Beynon RJ, Crews CM. Chem Biol. 2011 Oct 28;18(10):1300-11. doi: 10.1016/j.chembiol.2011.07.020. PubMed |
| Optimal functional levels of activation-induced deaminase specifically require the Hsp40 DnaJa1. Orthwein A, Zahn A, Methot SP, Godin D, Conticello SG, Terada K, Di Noia JM. EMBO J. 2012 Feb 1;31(3):679-91. doi: 10.1038/emboj.2011.417. Epub 2011 Nov 15. PubMed |
| FGF signalling inhibits neural induction in human embryonic stem cells. Greber B, Coulon P, Zhang M, Moritz S, Frank S, Muller-Molina AJ, Arauzo-Bravo MJ, Han DW, Pape HC, Scholer HR. EMBO J. 2011 Nov 15;30(24):4874-84. doi: 10.1038/emboj.2011.407. PubMed |
| Novel reporter systems for facile evaluation of I-SceI-mediated genome editing. Munoz NM, Beard BC, Ryu BY, Luche RM, Trobridge GD, Rawlings DJ, Scharenberg AM, Kiem HP. Nucleic Acids Res. 2012 Jan;40(2):e14. doi: 10.1093/nar/gkr897. Epub 2011 Nov 21. PubMed |
| Defining MAP3 kinases required for MDA-MB-231 cell tumor growth and metastasis. Cronan MR, Nakamura K, Johnson NL, Granger DA, Cuevas BD, Wang JG, Mackman N, Scott JE, Dohlman HG, Johnson GL. Oncogene. 2012 Aug 23;31(34):3889-900. doi: 10.1038/onc.2011.544. Epub 2011 Dec 5. PubMed |
| Development of immortalized hepatocyte-like cells from hMSCs. Wongkajornsilp A, Sa-Ngiamsuntorn K, Hongeng S. Methods Mol Biol. 2012;826:73-87. doi: 10.1007/978-1-61779-468-1_7. PubMed |
Efficient conversion of astrocytes to functional midbrain dopaminergic neurons using a single polycistronic vector.
Addis RC, Hsu FC, Wright RL, Dichter MA, Coulter DA, Gearhart JD.
PLoS One. 2011;6(12):e28719. doi: 10.1371/journal.pone.0028719. Epub 2011 Dec 9.
PubMed
Associated Plasmids |
Modulation of Wnt/beta-catenin signaling in human embryonic stem cells using a 3-D microwell array.
Azarin SM, Lian X, Larson EA, Popelka HM, de Pablo JJ, Palecek SP.
Biomaterials. 2012 Mar;33(7):2041-9. Epub 2011 Dec 15.
PubMed
Associated Plasmids |
| Pygo2 regulates histone gene expression and H3 K56 acetylation in human mammary epithelial cells. Gu B, Watanabe K, Dai X. Cell Cycle. 2012 Jan 1;11(1):79-87. doi: 10.4161/cc.11.1.18402. Epub 2012 Jan 1. PubMed |
| Reprogramming of mouse, rat, pig, and human fibroblasts into iPS cells. Rajarajan K, Engels MC, Wu SM. Curr Protoc Mol Biol. 2012 Jan;Chapter 23:Unit 23.15.. doi: 10.1002/0471142727.mb2315s97. PubMed |
| IGF2BP1 promotes cell migration by regulating MK5 and PTEN signaling. Stohr N, Kohn M, Lederer M, Glass M, Reinke C, Singer RH, Huttelmaier S. Genes Dev. 2012 Jan 15;26(2):176-89. doi: 10.1101/gad.177642.111. PubMed |
| The aryl hydrocarbon receptor contributes to the proliferation of human medulloblastoma cells. Dever DP, Opanashuk LA. Mol Pharmacol. 2012 May;81(5):669-78. doi: 10.1124/mol.111.077305. Epub 2012 Feb 6. PubMed |
| Potassium channel mutant KCNJ5 T158A expression in HAC-15 cells increases aldosterone synthesis. Oki K, Plonczynski MW, Luis Lam M, Gomez-Sanchez EP, Gomez-Sanchez CE. Endocrinology. 2012 Apr;153(4):1774-82. doi: 10.1210/en.2011-1733. Epub 2012 Feb 7. PubMed |
| Outgrowth of single oncogene-expressing cells from suppressive epithelial environments. Leung CT, Brugge JS. Nature. 2012 Feb 8;482(7385):410-3. doi: 10.1038/nature10826. PubMed |
| Retinoblastoma tumor-suppressor protein phosphorylation and inactivation depend on direct interaction with Pin1. Rizzolio F, Lucchetti C, Caligiuri I, Marchesi I, Caputo M, Klein-Szanto AJ, Bagella L, Castronovo M, Giordano A. Cell Death Differ. 2012 Jul;19(7):1152-61. doi: 10.1038/cdd.2011.202. Epub 2012 Feb 10. PubMed |
| Angiogenic properties of myofibroblasts isolated from normal human skin wounds. Mayrand D, Laforce-Lavoie A, Larochelle S, Langlois A, Genest H, Roy M, Moulin VJ. Angiogenesis. 2012 Jun;15(2):199-212. doi: 10.1007/s10456-012-9253-5. Epub 2012 Feb 18. PubMed |
| Real-time bioluminescence and tomographic imaging of gastric cancer in a novel orthotopic mouse model. Hu H, Liu J, Yao L, Yin J, Su N, Liu X, Cao F, Liang J, Nie Y, Wu K. Oncol Rep. 2012 Jun;27(6):1937-43. doi: 10.3892/or.2012.1713. Epub 2012 Mar 7. PubMed |
| Expression of prolyl hydroxylases (PHDs) is selectively controlled by HIF-1 and HIF-2 proteins in nucleus pulposus cells of the intervertebral disc: distinct roles of PHD2 and PHD3 proteins in controlling HIF-1alpha activity in hypoxia. Fujita N, Markova D, Anderson DG, Chiba K, Toyama Y, Shapiro IM, Risbud MV. J Biol Chem. 2012 May 11;287(20):16975-86. doi: 10.1074/jbc.M111.334466. Epub 2012 Mar 26. PubMed |
| 3' self-inactivating long terminal repeat inserts for the modulation of transgene expression from lentiviral vectors. Manic G, Maurin-Marlin A, Galluzzi L, Subra F, Mouscadet JF, Bury-Mone S. Hum Gene Ther Methods. 2012 Apr;23(2):84-97. doi: 10.1089/hgtb.2011.154. Epub 2012 Mar 28. PubMed |
| Pathogen-induced human TH17 cells produce IFN-gamma or IL-10 and are regulated by IL-1beta. Zielinski CE, Mele F, Aschenbrenner D, Jarrossay D, Ronchi F, Gattorno M, Monticelli S, Lanzavecchia A, Sallusto F. Nature. 2012 Apr 26;484(7395):514-8. doi: 10.1038/nature10957. PubMed |
| Heightened expression of MICA enhances the cytotoxicity of NK cells or CD8+T cells to human corneal epithelium in vitro. Hong J, Qiu T, Qian T, Li G, Yu X, Chen J, Le Q, Sun X, Xu J. BMC Ophthalmol. 2012 Apr 4;12:6. doi: 10.1186/1471-2415-12-6. PubMed |
| Zfp296 is a novel, pluripotent-specific reprogramming factor. Fischedick G, Klein DC, Wu G, Esch D, Hoing S, Han DW, Reinhardt P, Hergarten K, Tapia N, Scholer HR, Sterneckert JL. PLoS One. 2012;7(4):e34645. doi: 10.1371/journal.pone.0034645. Epub 2012 Apr 2. PubMed |
| Carbonic anhydrase III regulates peroxisome proliferator-activated receptor-gamma2. Mitterberger MC, Kim G, Rostek U, Levine RL, Zwerschke W. Exp Cell Res. 2012 May 1;318(8):877-86. doi: 10.1016/j.yexcr.2012.02.011. Epub 2012 Feb 28. PubMed |
| Myosin Ia is required for CFTR brush border membrane trafficking and ion transport in the mouse small intestine. Kravtsov DV, Caputo C, Collaco A, Hoekstra N, Egan ME, Mooseker MS, Ameen NA. Traffic. 2012 Aug;13(8):1072-82. doi: 10.1111/j.1600-0854.2012.01368.x. Epub 2012 May 8. PubMed |
| Nanotopography as modulator of human mesenchymal stem cell function. Kulangara K, Yang Y, Yang J, Leong KW. Biomaterials. 2012 Jul;33(20):4998-5003. doi: 10.1016/j.biomaterials.2012.03.053. Epub 2012 Apr 18. PubMed |
| Aire promotes the self-renewal of embryonic stem cells through Lin28. Bin G, Jiarong Z, Shihao W, Xiuli S, Cheng X, Liangbiao C, Ming Z. Stem Cells Dev. 2012 Oct 10;21(15):2878-90. doi: 10.1089/scd.2012.0097. Epub 2012 Jun 11. PubMed |
| LASS2 enhances chemosensitivity of breast cancer by counteracting acidic tumor microenvironment through inhibiting activity of V-ATPase proton pump. Fan S, Niu Y, Tan N, Wu Z, Wang Y, You H, Ke R, Song J, Shen Q, Wang W, Yao G, Shu H, Lin H, Yao M, Zhang Z, Gu J, Qin W. Oncogene. 2013 Mar 28;32(13):1682-90. doi: 10.1038/onc.2012.183. Epub 2012 May 14. PubMed |
| Identification of novel human damage response proteins targeted through yeast orthology. Svensson JP, Fry RC, Wang E, Somoza LA, Samson LD. PLoS One. 2012;7(5):e37368. doi: 10.1371/journal.pone.0037368. Epub 2012 May 16. PubMed |
| MARCKS regulates growth and radiation sensitivity and is a novel prognostic factor for glioma. Jarboe JS, Anderson JC, Duarte CW, Mehta T, Nowsheen S, Hicks PH, Whitley AC, Rohrbach TD, McCubrey RO, Chiu S, Burleson TM, Bonner JA, Gillespie GY, Yang ES, Willey CD. Clin Cancer Res. 2012 Jun 1;18(11):3030-41. doi: 10.1158/1078-0432.CCR-11-3091. Epub 2012 May 22. PubMed |
| DLK1(PREF1) is a negative regulator of adipogenesis in CD105(+)/CD90(+)/CD34(+)/CD31(-)/FABP4(-) adipose-derived stromal cells from subcutaneous abdominal fat pats of adult women. Mitterberger MC, Lechner S, Mattesich M, Kaiser A, Probst D, Wenger N, Pierer G, Zwerschke W. Stem Cell Res. 2012 Jul;9(1):35-48. doi: 10.1016/j.scr.2012.04.001. Epub 2012 Apr 17. PubMed |
| Smad3 controls beta-1,3-glucuronosyltransferase 1 expression in rat nucleus pulposus cells: implications of dysregulated expression in disc disease. Wu Q, Wang J, Skubutyte R, Kepler CK, Huang Z, Anderson DG, Shapiro IM, Risbud MV. Arthritis Rheum. 2012 Oct;64(10):3324-33. doi: 10.1002/art.34570. PubMed |
| Morphology of axonal projections from the high vocal center to vocal motor cortex in songbirds. Yip ZC, Miller-Sims VC, Bottjer SW. J Comp Neurol. 2012 Aug 15;520(12):2742-56. doi: 10.1002/cne.23084. PubMed |
| A versatile lentiviral expression system to identify mammalian protein-protein interactions. Mak AB, Moffat J. Methods. 2012 Aug;57(4):409-16. doi: 10.1016/j.ymeth.2012.06.005. Epub 2012 Jun 17. PubMed |
| Phosphorylation of p65(RelA) on Ser(547) by ATM represses NF-kappaB-dependent transcription of specific genes after genotoxic stress. Sabatel H, Di Valentin E, Gloire G, Dequiedt F, Piette J, Habraken Y. PLoS One. 2012;7(6):e38246. doi: 10.1371/journal.pone.0038246. Epub 2012 Jun 8. PubMed |
| Iterative capped assembly: rapid and scalable synthesis of repeat-module DNA such as TAL effectors from individual monomers. Briggs AW, Rios X, Chari R, Yang L, Zhang F, Mali P, Church GM. Nucleic Acids Res. 2012 Aug;40(15):e117. doi: 10.1093/nar/gks624. Epub 2012 Jun 26. PubMed |
| Role of mismatch repair enzymes in GAA.TTC triplet-repeat expansion in Friedreich ataxia induced pluripotent stem cells. Du J, Campau E, Soragni E, Ku S, Puckett JW, Dervan PB, Gottesfeld JM. J Biol Chem. 2012 Aug 24;287(35):29861-72. doi: 10.1074/jbc.M112.391961. Epub 2012 Jul 13. PubMed |
| Expression of the PTTG1 oncogene is associated with aggressive clear cell renal cell carcinoma. Wondergem B, Zhang Z, Huang D, Ong CK, Koeman J, Hof DV, Petillo D, Ooi A, Anema J, Lane B, Kahnoski RJ, Furge KA, Teh BT. Cancer Res. 2012 Sep 1;72(17):4361-71. doi: 10.1158/0008-5472.CAN-11-2330. Epub 2012 Jul 17. PubMed |
| Cytokine secretion by CD4+ T cells at the immunological synapse requires Cdc42-dependent local actin remodeling but not microtubule organizing center polarity. Chemin K, Bohineust A, Dogniaux S, Tourret M, Guegan S, Miro F, Hivroz C. J Immunol. 2012 Sep 1;189(5):2159-68. doi: 10.4049/jimmunol.1200156. Epub 2012 Jul 20. PubMed |
| ASC-dependent RIP2 kinase regulates reduced PGE2 production in chronic periodontitis. Taxman DJ, Lei Y, Zhang S, Holley-Guthrie E, Offenbacher S, Ting JP. J Dent Res. 2012 Sep;91(9):877-82. doi: 10.1177/0022034512454541. Epub 2012 Jul 24. PubMed |
| AV-65, a novel Wnt/beta-catenin signal inhibitor, successfully suppresses progression of multiple myeloma in a mouse model. Yao H, Ashihara E, Strovel JW, Nakagawa Y, Kuroda J, Nagao R, Tanaka R, Yokota A, Takeuchi M, Hayashi Y, Shimazaki C, Taniwaki M, Strand K, Padia J, Hirai H, Kimura S, Maekawa T. Blood Cancer J. 2011 Nov;1(11):e43. doi: 10.1038/bcj.2011.41. Epub 2011 Nov 4. PubMed |
| Synthesis and evaluation of hybrid drugs for a potential HIV/AIDS-malaria combination therapy. Aminake MN, Mahajan A, Kumar V, Hans R, Wiesner L, Taylor D, de Kock C, Grobler A, Smith PJ, Kirschner M, Rethwilm A, Pradel G, Chibale K. Bioorg Med Chem. 2012 Sep 1;20(17):5277-89. doi: 10.1016/j.bmc.2012.06.038. Epub 2012 Jun 29. PubMed |
| Genetic background affects induced pluripotent stem cell generation. Schnabel LV, Abratte CM, Schimenti JC, Southard TL, Fortier LA. Stem Cell Res Ther. 2012 Aug 3;3(4):30. doi: 10.1186/scrt121. PubMed |
| Inhibiting adipose tissue lipogenesis reprograms thermogenesis and PPARgamma activation to decrease diet-induced obesity. Lodhi IJ, Yin L, Jensen-Urstad AP, Funai K, Coleman T, Baird JH, El Ramahi MK, Razani B, Song H, Fu-Hsu F, Turk J, Semenkovich CF. Cell Metab. 2012 Aug 8;16(2):189-201. PubMed |
| Androgen receptor serine 81 mediates Pin1 interaction and activity. La Montagna R, Caligiuri I, Maranta P, Lucchetti C, Esposito L, Paggi MG, Toffoli G, Rizzolio F, Giordano A. Cell Cycle. 2012 Sep 15;11(18):3415-20. doi: 10.4161/cc.21730. Epub 2012 Aug 16. PubMed |
| Peroxiredoxin 1 functions as a signal peroxidase to receive, transduce, and transmit peroxide signals in mammalian cells. Jarvis RM, Hughes SM, Ledgerwood EC. Free Radic Biol Med. 2012 Oct 1;53(7):1522-30. doi: 10.1016/j.freeradbiomed.2012.08.001. Epub 2012 Aug 8. PubMed |
| Elevating SOX2 levels deleteriously affects the growth of medulloblastoma and glioblastoma cells. Cox JL, Wilder PJ, Desler M, Rizzino A. PLoS One. 2012;7(8):e44087. doi: 10.1371/journal.pone.0044087. Epub 2012 Aug 28. PubMed |
| Prolyl hydroxylase 3 (PHD3) modulates catabolic effects of tumor necrosis factor-alpha (TNF-alpha) on cells of the nucleus pulposus through co-activation of nuclear factor kappaB (NF-kappaB)/p65 signaling. Fujita N, Gogate SS, Chiba K, Toyama Y, Shapiro IM, Risbud MV. J Biol Chem. 2012 Nov 16;287(47):39942-53. doi: 10.1074/jbc.M112.375964. Epub 2012 Sep 4. PubMed |
| Autophagy plays a protective role in endoplasmic reticulum stress-mediated pancreatic beta cell death. Bartolome A, Guillen C, Benito M. Autophagy. 2012 Dec;8(12):1757-68. doi: 10.4161/auto.21994. Epub 2012 Sep 5. PubMed |
| AIF-mediated caspase-independent necroptosis requires ATM and DNA-PK-induced histone H2AX Ser139 phosphorylation. Baritaud M, Cabon L, Delavallee L, Galan-Malo P, Gilles ME, Brunelle-Navas MN, Susin SA. Cell Death Dis. 2012 Sep 13;3:e390. doi: 10.1038/cddis.2012.120. PubMed |
| The ablation of EZH2 uncovers its crucial role in rhabdomyosarcoma formation. Marchesi I, Fiorentino FP, Rizzolio F, Giordano A, Bagella L. Cell Cycle. 2012 Oct 15;11(20):3828-36. doi: 10.4161/cc.22025. Epub 2012 Sep 14. PubMed |
| Calcium-permeable alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors trigger neuronal nitric-oxide synthase activation to promote nerve cell death in an Src kinase-dependent fashion. Socodato R, Santiago FN, Portugal CC, Domingues AF, Santiago AR, Relvas JB, Ambrosio AF, Paes-de-Carvalho R. J Biol Chem. 2012 Nov 9;287(46):38680-94. doi: 10.1074/jbc.M112.353961. Epub 2012 Sep 19. PubMed |
| Codon-usage-based inhibition of HIV protein synthesis by human schlafen 11. Li M, Kao E, Gao X, Sandig H, Limmer K, Pavon-Eternod M, Jones TE, Landry S, Pan T, Weitzman MD, David M. Nature. 2012 Nov 1;491(7422):125-8. doi: 10.1038/nature11433. Epub 2012 Sep 23. PubMed |
| The cellular ataxia telangiectasia-mutated kinase promotes epstein-barr virus lytic reactivation in response to multiple different types of lytic reactivation-inducing stimuli. Hagemeier SR, Barlow EA, Meng Q, Kenney SC. J Virol. 2012 Dec;86(24):13360-70. doi: 10.1128/JVI.01850-12. Epub 2012 Sep 26. PubMed |
| Identification of alternatively translated Tetherin isoforms with differing antiviral and signaling activities. Cocka LJ, Bates P. PLoS Pathog. 2012 Sep;8(9):e1002931. doi: 10.1371/journal.ppat.1002931. Epub 2012 Sep 27. PubMed |
| Synergistic antitumor effects of endostar in combination with oxaliplatin via inhibition of HIF and CXCR4 in the colorectal cell line SW1116. Jin F, Ji H, Jia C, Brockmeier U, Hermann DM, Metzen E, Zhu Y, Chi B. PLoS One. 2012;7(10):e47161. doi: 10.1371/journal.pone.0047161. Epub 2012 Oct 10. PubMed |
| Functional analysis of in-frame indel ARID1A mutations reveals new regulatory mechanisms of its tumor suppressor functions. Guan B, Gao M, Wu CH, Wang TL, Shih IeM. Neoplasia. 2012 Oct;14(10):986-93. PubMed |
| Influenza virus induces apoptosis via BAD-mediated mitochondrial dysregulation. Tran AT, Cortens JP, Du Q, Wilkins JA, Coombs KM. J Virol. 2013 Jan;87(2):1049-60. doi: 10.1128/JVI.02017-12. Epub 2012 Nov 7. PubMed |
| Histone deacetylase inhibition activates transgene expression from integration-defective lentiviral vectors in dividing and non-dividing cells. Pelascini LP, Janssen JM, Goncalves MA. Hum Gene Ther. 2013 Jan;24(1):78-96. doi: 10.1089/hum.2012.069. Epub 2012 Dec 11. PubMed |
| Impact of sustained RNAi-mediated suppression of cellular cofactor Tat-SF1 on HIV-1 replication in CD4+ T cells. Green VA, Arbuthnot P, Weinberg MS. Virol J. 2012 Nov 15;9:272. doi: 10.1186/1743-422X-9-272. PubMed |
| Comparison of mixed and lamellar coculture spatial arrangements for tissue engineering capillary networks in vitro. Peters EB, Christoforou N, Leong KW, Truskey GA. Tissue Eng Part A. 2013 Mar;19(5-6):697-706. doi: 10.1089/ten.tea.2011.0704. Epub 2012 Nov 21. PubMed |
| Role of early B-cell factor 1 (EBF1) in Hodgkin lymphoma. Bohle V, Doring C, Hansmann ML, Kuppers R. Leukemia. 2013 Mar;27(3):671-9. doi: 10.1038/leu.2012.280. Epub 2012 Oct 1. PubMed |
| Insulin inhibits cardiac mesoderm, not mesendoderm, formation during cardiac differentiation of human pluripotent stem cells and modulation of canonical Wnt signaling can rescue this inhibition. Lian X, Zhang J, Zhu K, Kamp TJ, Palecek SP. Stem Cells. 2013 Mar;31(3):447-57. doi: 10.1002/stem.1289. PubMed |
| Tissue-specific interaction of Per1/2 and Dec2 in the regulation of fibroblast circadian rhythms. Tsang AH, Sanchez-Moreno C, Bode B, Rossner MJ, Garaulet M, Oster H. J Biol Rhythms. 2012 Dec;27(6):478-89. doi: 10.1177/0748730412462838. PubMed |
| Tumor necrosis factor alpha- and interleukin-1beta-dependent induction of CCL3 expression by nucleus pulposus cells promotes macrophage migration through CCR1. Wang J, Tian Y, Phillips KL, Chiverton N, Haddock G, Bunning RA, Cross AK, Shapiro IM, Le Maitre CL, Risbud MV. Arthritis Rheum. 2013 Mar;65(3):832-42. doi: 10.1002/art.37819. PubMed |
| Directed cardiomyocyte differentiation from human pluripotent stem cells by modulating Wnt/beta-catenin signaling under fully defined conditions. Lian X, Zhang J, Azarin SM, Zhu K, Hazeltine LB, Bao X, Hsiao C, Kamp TJ, Palecek SP. Nat Protoc. 2013 Jan;8(1):162-75. doi: 10.1038/nprot.2012.150. Epub 2012 Dec 20. PubMed |
| Ribosomal protein S25 dependency reveals a common mechanism for diverse internal ribosome entry sites and ribosome shunting. Hertz MI, Landry DM, Willis AE, Luo G, Thompson SR. Mol Cell Biol. 2013 Mar;33(5):1016-26. doi: 10.1128/MCB.00879-12. Epub 2012 Dec 28. PubMed |
| Differential integrity of TALE nuclease genes following adenoviral and lentiviral vector gene transfer into human cells. Holkers M, Maggio I, Liu J, Janssen JM, Miselli F, Mussolino C, Recchia A, Cathomen T, Goncalves MA. Nucleic Acids Res. 2013 Mar 1;41(5):e63. doi: 10.1093/nar/gks1446. Epub 2012 Dec 28. PubMed |
| RNA-interacting proteins act as site-specific repressors of ADAR2-mediated RNA editing and fluctuate upon neuronal stimulation. Tariq A, Garncarz W, Handl C, Balik A, Pusch O, Jantsch MF. Nucleic Acids Res. 2013 Feb 1;41(4):2581-93. doi: 10.1093/nar/gks1353. Epub 2012 Dec 28. PubMed |
| Gene-specific factors determine mitotic expression and bookmarking via alternate regulatory elements. Arampatzi P, Gialitakis M, Makatounakis T, Papamatheakis J. Nucleic Acids Res. 2013 Feb 1;41(4):2202-15. doi: 10.1093/nar/gks1365. Epub 2013 Jan 8. PubMed |
| Role of C/EBPbeta-LAP and C/EBPbeta-LIP in early adipogenic differentiation of human white adipose-derived progenitors and at later stages in immature adipocytes. Lechner S, Mitterberger MC, Mattesich M, Zwerschke W. Differentiation. 2013 Jan;85(1-2):20-31. doi: 10.1016/j.diff.2012.11.001. Epub 2013 Jan 11. PubMed |
| RNAi-mediated gene function analysis in skin. Beronja S, Fuchs E. Methods Mol Biol. 2013;961:351-61. doi: 10.1007/978-1-62703-227-8_23. PubMed |
| An analysis and validation pipeline for large-scale RNAi-based screens. Plank M, Hu G, Silva AS, Wood SH, Hesketh EE, Janssens G, Macedo A, de Magalhaes JP, Church GM. Sci Rep. 2013;3:1076. doi: 10.1038/srep01076. Epub 2013 Jan 16. PubMed |
| Gene transduction in human monocyte-derived dendritic cells using lentiviral vectors. Satoh T, Manel N. Methods Mol Biol. 2013;960:401-9. doi: 10.1007/978-1-62703-218-6_30. PubMed |
| Nonviral direct conversion of primary mouse embryonic fibroblasts to neuronal cells. Adler AF, Grigsby CL, Kulangara K, Wang H, Yasuda R, Leong KW. Mol Ther Nucleic Acids. 2012 Jul 10;1:e32. doi: 10.1038/mtna.2012.25. PubMed |
| alpha-Synuclein membrane association is regulated by the Rab3a recycling machinery and presynaptic activity. Chen RH, Wislet-Gendebien S, Samuel F, Visanji NP, Zhang G, Marsilio D, Langman T, Fraser PE, Tandon A. J Biol Chem. 2013 Mar 15;288(11):7438-49. doi: 10.1074/jbc.M112.439497. Epub 2013 Jan 23. PubMed |
| A high-throughput screen to identify enhancers of ADAR-mediated RNA-editing. Garncarz W, Tariq A, Handl C, Pusch O, Jantsch MF. RNA Biol. 2013 Feb;10(2):192-204. doi: 10.4161/rna.23208. Epub 2013 Jan 25. PubMed |
| Identification of CDCP1 as a hypoxia-inducible factor 2alpha (HIF-2alpha) target gene that is associated with survival in clear cell renal cell carcinoma patients. Emerling BM, Benes CH, Poulogiannis G, Bell EL, Courtney K, Liu H, Choo-Wing R, Bellinger G, Tsukazawa KS, Brown V, Signoretti S, Soltoff SP, Cantley LC. Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3483-8. doi: 10.1073/pnas.1222435110. Epub 2013 Feb 1. PubMed |
| Hypertonic stress promotes autophagy and microtubule-dependent autophagosomal clusters. Nunes P, Ernandez T, Roth I, Qiao X, Strebel D, Bouley R, Charollais A, Ramadori P, Foti M, Meda P, Feraille E, Brown D, Hasler U. Autophagy. 2013 Apr;9(4):550-67. doi: 10.4161/auto.23662. Epub 2013 Feb 4. PubMed |
| The prolyl isomerase Pin1 acts synergistically with CDK2 to regulate the basal activity of estrogen receptor alpha in breast cancer. Lucchetti C, Caligiuri I, Toffoli G, Giordano A, Rizzolio F. PLoS One. 2013;8(2):e55355. doi: 10.1371/journal.pone.0055355. Epub 2013 Feb 4. PubMed |
| CD44 is involved in mineralization of dental pulp cells. Chen KL, Huang YY, Lung J, Yeh YY, Yuan K. J Endod. 2013 Mar;39(3):351-6. doi: 10.1016/j.joen.2012.11.043. Epub 2013 Jan 16. PubMed |
| Identification of tribbles-1 as a novel binding partner of Foxp3 in regulatory T cells. Dugast E, Kiss-Toth E, Docherty L, Danger R, Chesneau M, Pichard V, Judor JP, Pettre S, Conchon S, Soulillou JP, Brouard S, Ashton-Chess J. J Biol Chem. 2013 Apr 5;288(14):10051-60. doi: 10.1074/jbc.M112.448654. Epub 2013 Feb 15. PubMed |
| hTERT extends the life of human fibroblasts without compromising type I interferon signaling. Smith MC, Goddard ET, Perusina Lanfranca M, Davido DJ. PLoS One. 2013;8(3):e58233. doi: 10.1371/journal.pone.0058233. Epub 2013 Mar 5. PubMed |
| Canonical Wnt signaling induces BMP-4 to specify slow myofibrogenesis of fetal myoblasts. Kuroda K, Kuang S, Taketo MM, Rudnicki MA. Skelet Muscle. 2013 Mar 5;3(1):5. doi: 10.1186/2044-5040-3-5. PubMed |
Sox10-MCS5 enhancer dynamically tracks human oligodendrocyte progenitor fate.
Pol SU, Lang JK, O'Bara MA, Cimato TR, McCallion AS, Sim FJ.
Exp Neurol. 2013 Sep;247:694-702. doi: 10.1016/j.expneurol.2013.03.010. Epub 2013 Mar 16.
PubMed
Associated Plasmids |
| Hypoxia-inducible factor (HIF)-1alpha and CCN2 form a regulatory circuit in hypoxic nucleus pulposus cells: CCN2 suppresses HIF-1alpha level and transcriptional activity. Tran CM, Fujita N, Huang BL, Ong JR, Lyons KM, Shapiro IM, Risbud MV. J Biol Chem. 2013 May 3;288(18):12654-66. doi: 10.1074/jbc.M112.448860. Epub 2013 Mar 24. PubMed |
| The ULb' region of the human cytomegalovirus genome confers an increased requirement for the viral protein kinase UL97. Wang D, Li G, Schauflinger M, Nguyen CC, Hall ED, Yurochko AD, von Einem J, Kamil JP. J Virol. 2013 Jun;87(11):6359-76. doi: 10.1128/JVI.03477-12. Epub 2013 Mar 27. PubMed |
| Nutrient-dependent phosphorylation channels lipid synthesis to regulate PPARalpha. Jensen-Urstad AP, Song H, Lodhi IJ, Funai K, Yin L, Coleman T, Semenkovich CF. J Lipid Res. 2013 Jul;54(7):1848-59. doi: 10.1194/jlr.M036103. Epub 2013 Apr 13. PubMed |
| Inflammatory cytokines induce NOTCH signaling in nucleus pulposus cells: implications in intervertebral disc degeneration. Wang H, Tian Y, Wang J, Phillips KL, Binch AL, Dunn S, Cross A, Chiverton N, Zheng Z, Shapiro IM, Le Maitre CL, Risbud MV. J Biol Chem. 2013 Jun 7;288(23):16761-74. doi: 10.1074/jbc.M112.446633. Epub 2013 Apr 15. PubMed |
Optimization of direct fibroblast reprogramming to cardiomyocytes using calcium activity as a functional measure of success.
Addis RC, Ifkovits JL, Pinto F, Kellam LD, Esteso P, Rentschler S, Christoforou N, Epstein JA, Gearhart JD.
J Mol Cell Cardiol. 2013 Apr 13;60C:97-106. doi: 10.1016/j.yjmcc.2013.04.004.
PubMed
Associated Plasmids |
| Inflammatory cytokines associated with degenerative disc disease control aggrecanase-1 (ADAMTS-4) expression in nucleus pulposus cells through MAPK and NF-kappaB. Tian Y, Yuan W, Fujita N, Wang J, Wang H, Shapiro IM, Risbud MV. Am J Pathol. 2013 Jun;182(6):2310-21. doi: 10.1016/j.ajpath.2013.02.037. Epub 2013 Apr 17. PubMed |
| 6-Shogaol inhibits breast and colon cancer cell proliferation through activation of peroxisomal proliferator activated receptor gamma (PPARgamma). Tan BS, Kang O, Mai CW, Tiong KH, Khoo AS, Pichika MR, Bradshaw TD, Leong CO. Cancer Lett. 2013 Aug 9;336(1):127-39. doi: 10.1016/j.canlet.2013.04.014. Epub 2013 Apr 21. PubMed |
| Prox1 directly interacts with LSD1 and recruits the LSD1/NuRD complex to epigenetically co-repress CYP7A1 transcription. Ouyang H, Qin Y, Liu Y, Xie Y, Liu J. PLoS One. 2013 Apr 23;8(4):e62192. doi: 10.1371/journal.pone.0062192. Print 2013. PubMed |
| Efficacious proteasome/HDAC inhibitor combination therapy for primary effusion lymphoma. Bhatt S, Ashlock BM, Toomey NL, Diaz LA, Mesri EA, Lossos IS, Ramos JC. J Clin Invest. 2013 Jun;123(6):2616-28. doi: 10.1172/JCI64503. Epub 2013 May 1. PubMed |
| Dyskeratosis congenita mutations in dyskerin SUMOylation consensus sites lead to impaired telomerase RNA accumulation and telomere defects. Brault ME, Lauzon C, Autexier C. Hum Mol Genet. 2013 Sep 1;22(17):3498-507. doi: 10.1093/hmg/ddt204. Epub 2013 May 8. PubMed |
| The B-cell-specific transcription factor and master regulator Pax5 promotes Epstein-Barr virus latency by negatively regulating the viral immediate early protein BZLF1. Raver RM, Panfil AR, Hagemeier SR, Kenney SC. J Virol. 2013 Jul;87(14):8053-63. doi: 10.1128/JVI.00546-13. Epub 2013 May 15. PubMed |
| Lentiviral vector production, titration, and transduction of primary neurons. Ding B, Kilpatrick DL. Methods Mol Biol. 2013;1018:119-31. doi: 10.1007/978-1-62703-444-9_12. PubMed |
| TAL effector nucleases induce mutations at a pre-selected location in the genome of primary barley transformants. Wendt T, Holm PB, Starker CG, Christian M, Voytas DF, Brinch-Pedersen H, Holme IB. Plant Mol Biol. 2013 Oct;83(3):279-85. doi: 10.1007/s11103-013-0078-4. Epub 2013 May 21. PubMed |
| Keratins control intercellular adhesion involving PKC-alpha-mediated desmoplakin phosphorylation. Kroger C, Loschke F, Schwarz N, Windoffer R, Leube RE, Magin TM. J Cell Biol. 2013 May 27;201(5):681-92. doi: 10.1083/jcb.201208162. Epub 2013 May 20. PubMed |
| Isolation, genetic manipulation, and transplantation of canine spermatogonial stem cells: progress toward transgenesis through the male germ-line. Harkey MA, Asano A, Zoulas ME, Torok-Storb B, Nagashima J, Travis A. Reproduction. 2013 Jun 14;146(1):75-90. doi: 10.1530/REP-13-0086. Print 2013 Jul. PubMed |
| Increased mutagenic joining of enzymatically-induced DNA double-strand breaks in high-charge and energy particle irradiated human cells. Li Z, Hudson FZ, Wang H, Wang Y, Bian Z, Murnane JP, Dynan WS. Radiat Res. 2013 Jul;180(1):17-24. doi: 10.1667/RR3332.1. Epub 2013 May 21. PubMed |
| Focal adhesion kinase is required for IGF-I-mediated growth of skeletal muscle cells via a TSC2/mTOR/S6K1-associated pathway. Crossland H, Kazi AA, Lang CH, Timmons JA, Pierre P, Wilkinson DJ, Smith K, Szewczyk NJ, Atherton PJ. Am J Physiol Endocrinol Metab. 2013 Jul 15;305(2):E183-93. doi: 10.1152/ajpendo.00541.2012. Epub 2013 May 21. PubMed |
| A robust strategy for negative selection of Cre-loxP recombination-based excision of transgenes in induced pluripotent stem cells. Chakraborty S, Christoforou N, Fattahi A, Herzog RW, Leong KW. PLoS One. 2013 May 22;8(5):e64342. doi: 10.1371/journal.pone.0064342. Print 2013. PubMed |
| Inhibiting Polo-like kinase 1 causes growth reduction and apoptosis in pediatric acute lymphoblastic leukemia cells. Hartsink-Segers SA, Exalto C, Allen M, Williamson D, Clifford SC, Horstmann M, Caron HN, Pieters R, Den Boer ML. Haematologica. 2013 Oct;98(10):1539-46. doi: 10.3324/haematol.2013.084434. Epub 2013 Jun 10. PubMed |
| Oxidative stress inhibits adhesion and transendothelial migration, and induces apoptosis and senescence of induced pluripotent stem cells. Wu Y, Zhang X, Kang X, Li N, Wang R, Hu T, Xiang M, Wang X, Yuan W, Chen A, Meng D, Chen S. Clin Exp Pharmacol Physiol. 2013 Sep;40(9):626-34. doi: 10.1111/1440-1681.12141. PubMed |
| Chemerin neutralization blocks hematopoietic stem cell osteoclastogenesis. Muruganandan S, Dranse HJ, Rourke JL, McMullen NM, Sinal CJ. Stem Cells. 2013 Oct;31(10):2172-82. doi: 10.1002/stem.1450. PubMed |
| The pluripotency factor nanog promotes breast cancer tumorigenesis and metastasis. Lu X, Mazur SJ, Lin T, Appella E, Xu Y. Oncogene. 2014 May 15;33(20):2655-64. doi: 10.1038/onc.2013.209. Epub 2013 Jun 17. PubMed |
| Acute-phase serum amyloid a in osteoarthritis: regulatory mechanism and proinflammatory properties. de Seny D, Cobraiville G, Charlier E, Neuville S, Esser N, Malaise D, Malaise O, Calvo FQ, Relic B, Malaise MG. PLoS One. 2013 Jun 12;8(6):e66769. doi: 10.1371/journal.pone.0066769. Print 2013. PubMed |
| A loss-of-function screen for phosphatases that regulate neurite outgrowth identifies PTPN12 as a negative regulator of TrkB tyrosine phosphorylation. Ambjorn M, Dubreuil V, Miozzo F, Nigon F, Moller B, Issazadeh-Navikas S, Berg J, Lees M, Sap J. PLoS One. 2013 Jun 13;8(6):e65371. doi: 10.1371/journal.pone.0065371. Print 2013. PubMed |
| Fibulin-2 is a driver of malignant progression in lung adenocarcinoma. Baird BN, Schliekelman MJ, Ahn YH, Chen Y, Roybal JD, Gill BJ, Mishra DK, Erez B, O'Reilly M, Yang Y, Patel M, Liu X, Thilaganathan N, Larina IV, Dickinson ME, West JL, Gibbons DL, Liu DD, Kim MP, Hicks JM, Wistuba II, Hanash SM, Kurie JM. PLoS One. 2013 Jun 10;8(6):e67054. doi: 10.1371/journal.pone.0067054. Print 2013. PubMed |
| Cyclin-dependent kinase 1-dependent phosphorylation of cAMP response element-binding protein decreases chromatin occupancy. Trinh AT, Kim SH, Chang HY, Mastrocola AS, Tibbetts RS. J Biol Chem. 2013 Aug 16;288(33):23765-75. doi: 10.1074/jbc.M113.464057. Epub 2013 Jun 27. PubMed |
| NGF upregulates the plasminogen activation inhibitor-1 in neurons via the calcineurin/NFAT pathway and the Down syndrome-related proteins DYRK1A and RCAN1 attenuate this effect. Stefos GC, Soppa U, Dierssen M, Becker W. PLoS One. 2013 Jun 25;8(6):e67470. doi: 10.1371/journal.pone.0067470. Print 2013. PubMed |
| Application of multiplexed kinase inhibitor beads to study kinome adaptations in drug-resistant leukemia. Cooper MJ, Cox NJ, Zimmerman EI, Dewar BJ, Duncan JS, Whittle MC, Nguyen TA, Jones LS, Ghose Roy S, Smalley DM, Kuan PF, Richards KL, Christopherson RI, Jin J, Frye SV, Johnson GL, Baldwin AS, Graves LM. PLoS One. 2013 Jun 24;8(6):e66755. doi: 10.1371/journal.pone.0066755. Print 2013. PubMed |
| The RNA-binding protein fused in sarcoma (FUS) functions downstream of poly(ADP-ribose) polymerase (PARP) in response to DNA damage. Mastrocola AS, Kim SH, Trinh AT, Rodenkirch LA, Tibbetts RS. J Biol Chem. 2013 Aug 23;288(34):24731-41. doi: 10.1074/jbc.M113.497974. Epub 2013 Jul 5. PubMed |
| Human innate immunity to Toxoplasma gondii is mediated by host caspase-1 and ASC and parasite GRA15. Gov L, Karimzadeh A, Ueno N, Lodoen MB. MBio. 2013 Jul 9;4(4). pii: e00255-13. doi: 10.1128/mBio.00255-13. PubMed |
| In vivo imaging of nitric oxide and hydrogen peroxide in cardiac myocytes. Sartoretto JL, Kalwa H, Romero N, Michel T. Methods Enzymol. 2013;528:61-78. doi: 10.1016/B978-0-12-405881-1.00004-5. PubMed |
| The DNA damage checkpoint precedes activation of ARF in response to escalating oncogenic stress during tumorigenesis. Evangelou K, Bartkova J, Kotsinas A, Pateras IS, Liontos M, Velimezi G, Kosar M, Liloglou T, Trougakos IP, Dyrskjot L, Andersen CL, Papaioannou M, Drosos Y, Papafotiou G, Hodny Z, Sosa-Pineda B, Wu XR, Klinakis A, Orntoft T, Lukas J, Bartek J, Gorgoulis VG. Cell Death Differ. 2013 Nov;20(11):1485-97. doi: 10.1038/cdd.2013.76. Epub 2013 Jul 12. PubMed |
| The Pitx2:miR-200c/141:noggin pathway regulates Bmp signaling and ameloblast differentiation. Cao H, Jheon A, Li X, Sun Z, Wang J, Florez S, Zhang Z, McManus MT, Klein OD, Amendt BA. Development. 2013 Aug;140(16):3348-59. doi: 10.1242/dev.089193. Epub 2013 Jul 17. PubMed |
| Transcriptional repression of Bim by a novel YY1-RelA complex is essential for the survival and growth of Multiple Myeloma. Potluri V, Noothi SK, Vallabhapurapu SD, Yoon SO, Driscoll JJ, Lawrie CH, Vallabhapurapu S. PLoS One. 2013 Jul 10;8(7):e66121. doi: 10.1371/journal.pone.0066121. Print 2013. PubMed |
| Neuropathic and inflammatory pain are modulated by tuberoinfundibular peptide of 39 residues. Dimitrov EL, Kuo J, Kohno K, Usdin TB. Proc Natl Acad Sci U S A. 2013 Aug 6;110(32):13156-61. doi: 10.1073/pnas.1306342110. Epub 2013 Jul 22. PubMed |
| GRP78-targeting subtilase cytotoxin sensitizes cancer cells to photodynamic therapy. Firczuk M, Gabrysiak M, Barankiewicz J, Domagala A, Nowis D, Kujawa M, Jankowska-Steifer E, Wachowska M, Glodkowska-Mrowka E, Korsak B, Winiarska M, Golab J. Cell Death Dis. 2013 Jul 25;4:e741. doi: 10.1038/cddis.2013.265. PubMed |
| Impairment of endothelial-myocardial interaction increases the susceptibility of cardiomyocytes to ischemia/reperfusion injury. Leucker TM, Ge ZD, Procknow J, Liu Y, Shi Y, Bienengraeber M, Warltier DC, Kersten JR. PLoS One. 2013 Jul 22;8(7):e70088. doi: 10.1371/journal.pone.0070088. Print 2013. PubMed |
| pRb controls estrogen receptor alpha protein stability and activity. Caligiuri I, Toffoli G, Giordano A, Rizzolio F. Oncotarget. 2013 Jun;4(6):875-83. PubMed |
| Length-dependent CTG.CAG triplet-repeat expansion in myotonic dystrophy patient-derived induced pluripotent stem cells. Du J, Campau E, Soragni E, Jespersen C, Gottesfeld JM. Hum Mol Genet. 2013 Dec 20;22(25):5276-87. doi: 10.1093/hmg/ddt386. Epub 2013 Aug 9. PubMed |
| Rab18 binds to hepatitis C virus NS5A and promotes interaction between sites of viral replication and lipid droplets. Salloum S, Wang H, Ferguson C, Parton RG, Tai AW. PLoS Pathog. 2013;9(8):e1003513. doi: 10.1371/journal.ppat.1003513. Epub 2013 Aug 1. PubMed |
| Knockdown of specific host factors protects against influenza virus-induced cell death. Tran AT, Rahim MN, Ranadheera C, Kroeker A, Cortens JP, Opanubi KJ, Wilkins JA, Coombs KM. Cell Death Dis. 2013 Aug 15;4:e769. doi: 10.1038/cddis.2013.296. PubMed |
| The zinc finger transcription factor ZXDC activates CCL2 gene expression by opposing BCL6-mediated repression. Ramsey JE, Fontes JD. Mol Immunol. 2013 Dec;56(4):768-80. doi: 10.1016/j.molimm.2013.07.001. Epub 2013 Aug 14. PubMed |
| Functions of huntingtin in germ layer specification and organogenesis. Nguyen GD, Molero AE, Gokhan S, Mehler MF. PLoS One. 2013 Aug 13;8(8):e72698. doi: 10.1371/journal.pone.0072698. eCollection 2013. PubMed |
| Mesenchymal stem cell survival in the infarcted heart is enhanced by lentivirus vector-mediated heat shock protein 27 expression. McGinley LM, McMahon J, Stocca A, Duffy A, Flynn A, O'Toole D, O'Brien T. Hum Gene Ther. 2013 Oct;24(10):840-51. doi: 10.1089/hum.2011.009. PubMed |
| PP2A-activating drugs selectively eradicate TKI-resistant chronic myeloid leukemic stem cells. Neviani P, Harb JG, Oaks JJ, Santhanam R, Walker CJ, Ellis JJ, Ferenchak G, Dorrance AM, Paisie CA, Eiring AM, Ma Y, Mao HC, Zhang B, Wunderlich M, May PC, Sun C, Saddoughi SA, Bielawski J, Blum W, Klisovic RB, Solt JA, Byrd JC, Volinia S, Cortes J, Huettner CS, Koschmieder S, Holyoake TL, Devine S, Caligiuri MA, Croce CM, Garzon R, Ogretmen B, Arlinghaus RB, Chen CS, Bittman R, Hokland P, Roy DC, Milojkovic D, Apperley J, Goldman JM, Reid A, Mulloy JC, Bhatia R, Marcucci G, Perrotti D. J Clin Invest. 2013 Oct;123(10):4144-57. doi: 10.1172/JCI68951. Epub 2013 Sep 3. PubMed |
| Unsaturated fatty acids prevent activation of NLRP3 inflammasome in human monocytes/macrophages. L'homme L, Esser N, Riva L, Scheen A, Paquot N, Piette J, Legrand-Poels S. J Lipid Res. 2013 Nov;54(11):2998-3008. doi: 10.1194/jlr.M037861. Epub 2013 Sep 3. PubMed |
| Kinetics of acrylodan-labelled cAMP-dependent protein kinase catalytic subunit denaturation. Kivi R, Loog M, Jemth P, Jarv J. Protein J. 2013 Oct;32(7):519-25. doi: 10.1007/s10930-013-9511-4. PubMed |
| Bone marrow-derived mesenchymal stem cells enhance angiogenesis via their alpha6beta1 integrin receptor. Carrion B, Kong YP, Kaigler D, Putnam AJ. Exp Cell Res. 2013 Nov 15;319(19):2964-76. doi: 10.1016/j.yexcr.2013.09.007. Epub 2013 Sep 19. PubMed |
| FMRP regulates actin filament organization via the armadillo protein p0071. Nolze A, Schneider J, Keil R, Lederer M, Huttelmaier S, Kessels MM, Qualmann B, Hatzfeld M. RNA. 2013 Nov;19(11):1483-96. doi: 10.1261/rna.037945.112. Epub 2013 Sep 23. PubMed |
| Improved lentiviral transduction of ALS motoneurons in vivo via dual targeting. O'Leary VB, Ovsepian SV, Bodeker M, Dolly JO. Mol Pharm. 2013 Nov 4;10(11):4195-206. doi: 10.1021/mp400247t. Epub 2013 Oct 11. PubMed |
| Secreted Frizzled-related protein potentiation versus inhibition of Wnt3a/beta-catenin signaling. Xavier CP, Melikova M, Chuman Y, Uren A, Baljinnyam B, Rubin JS. Cell Signal. 2014 Jan;26(1):94-101. doi: 10.1016/j.cellsig.2013.09.016. Epub 2013 Sep 28. PubMed |
| Thalamic neuropeptide mediating the effects of nursing on lactation and maternal motivation. Cservenak M, Szabo ER, Bodnar I, Leko A, Palkovits M, Nagy GM, Usdin TB, Dobolyi A. Psychoneuroendocrinology. 2013 Dec;38(12):3070-84. doi: 10.1016/j.psyneuen.2013.09.004. Epub 2013 Sep 14. PubMed |
| Human F1F0 ATP synthase, mitochondrial ultrastructure and OXPHOS impairment: a (super-)complex matter? Habersetzer J, Larrieu I, Priault M, Salin B, Rossignol R, Brethes D, Paumard P. PLoS One. 2013 Oct 2;8(10):e75429. doi: 10.1371/journal.pone.0075429. eCollection 2013. PubMed |
| Role of JunB in adenosine A2B receptor-mediated vascular endothelial growth factor production. Ryzhov S, Biktasova A, Goldstein AE, Zhang Q, Biaggioni I, Dikov MM, Feoktistov I. Mol Pharmacol. 2014 Jan;85(1):62-73. doi: 10.1124/mol.113.088567. Epub 2013 Oct 17. PubMed |
| Doxycycline-regulated GDNF expression promotes axonal regeneration and functional recovery in transected peripheral nerve. Shakhbazau A, Mohanty C, Shcharbin D, Bryszewska M, Caminade AM, Majoral JP, Alant J, Midha R. J Control Release. 2013 Dec 28;172(3):841-51. doi: 10.1016/j.jconrel.2013.10.004. Epub 2013 Oct 17. PubMed |
| CD36-specific antibodies block release of HIV-1 from infected primary macrophages and its transmission to T cells. Berre S, Gaudin R, Cunha de Alencar B, Desdouits M, Chabaud M, Naffakh N, Rabaza-Gairi M, Gobert FX, Jouve M, Benaroch P. J Exp Med. 2013 Nov 18;210(12):2523-38. doi: 10.1084/jem.20130566. Epub 2013 Oct 21. PubMed |
| Depletion of a putatively druggable class of phosphatidylinositol kinases inhibits growth of p53-null tumors. Emerling BM, Hurov JB, Poulogiannis G, Tsukazawa KS, Choo-Wing R, Wulf GM, Bell EL, Shim HS, Lamia KA, Rameh LE, Bellinger G, Sasaki AT, Asara JM, Yuan X, Bullock A, Denicola GM, Song J, Brown V, Signoretti S, Cantley LC. Cell. 2013 Nov 7;155(4):844-57. doi: 10.1016/j.cell.2013.09.057. PubMed |
| Establishing isogenic inducible cell lines using founder reporter lines and recombinase-mediated cassette exchange. Guan B, Magomi T, Wang TL, Shih IeM. Biotechniques. 2013 Nov;55(5):233-42. doi: 10.2144/000114098. PubMed |
| In vitro expansion and genetic modification of gastrointestinal stem cells in spheroid culture. Miyoshi H, Stappenbeck TS. Nat Protoc. 2013 Dec;8(12):2471-82. doi: 10.1038/nprot.2013.153. Epub 2013 Nov 14. PubMed |
| Adherens junction formation inhibits lentivirus entry and gene transfer. Padmashali R, You H, Karnik N, Lei P, Andreadis ST. PLoS One. 2013 Nov 13;8(11):e79265. doi: 10.1371/journal.pone.0079265. eCollection 2013. PubMed |
| Increased expression of S100A6 promotes cell proliferation and migration in human hepatocellular carcinoma. Li Z, Tang M, Ling B, Liu S, Zheng Y, Nie C, Yuan Z, Zhou L, Guo G, Tong A, Wei Y. J Mol Med (Berl). 2014 Mar;92(3):291-303. doi: 10.1007/s00109-013-1104-3. Epub 2013 Nov 27. PubMed |
| Reduced expression of the chromatin remodeling gene ARID1A enhances gastric cancer cell migration and invasion via downregulation of E-cadherin transcription. Yan HB, Wang XF, Zhang Q, Tang ZQ, Jiang YH, Fan HZ, Sun YH, Yang PY, Liu F. Carcinogenesis. 2014 Apr;35(4):867-76. doi: 10.1093/carcin/bgt398. Epub 2013 Nov 30. PubMed |
| A potassium leak channel silences hyperactive neurons and ameliorates status epilepticus. Dey D, Eckle VS, Vitko I, Sullivan KA, Lasiecka ZM, Winckler B, Stornetta RL, Williamson JM, Kapur J, Perez-Reyes E. Epilepsia. 2014 Feb;55(2):203-13. doi: 10.1111/epi.12472. Epub 2013 Dec 2. PubMed |
| Visualizing of signaling proteins on endosomes utilizing knockdown and reconstitution approach. Jeoung M, Galperin E. Methods Enzymol. 2014;534:47-63. doi: 10.1016/B978-0-12-397926-1.00003-2. PubMed |
| Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging. Gomes AP, Price NL, Ling AJ, Moslehi JJ, Montgomery MK, Rajman L, White JP, Teodoro JS, Wrann CD, Hubbard BP, Mercken EM, Palmeira CM, de Cabo R, Rolo AP, Turner N, Bell EL, Sinclair DA. Cell. 2013 Dec 19;155(7):1624-38. doi: 10.1016/j.cell.2013.11.037. PubMed |
| Pore-exposed tyrosine residues of P-glycoprotein are important hydrogen-bonding partners for drugs. Donmez Cakil Y, Khunweeraphong N, Parveen Z, Schmid D, Artaker M, Ecker GF, Sitte HH, Pusch O, Stockner T, Chiba P. Mol Pharmacol. 2014 Mar;85(3):420-8. doi: 10.1124/mol.113.088526. Epub 2013 Dec 23. PubMed |
| BET bromodomain inhibition triggers apoptosis of NF1-associated malignant peripheral nerve sheath tumors through Bim induction. Patel AJ, Liao CP, Chen Z, Liu C, Wang Y, Le LQ. Cell Rep. 2014 Jan 16;6(1):81-92. doi: 10.1016/j.celrep.2013.12.001. Epub 2013 Dec 27. PubMed |
Tight control of hypoxia-inducible factor-alpha transient dynamics is essential for cell survival in hypoxia.
Bagnall J, Leedale J, Taylor SE, Spiller DG, White MR, Sharkey KJ, Bearon RN, See V.
J Biol Chem. 2014 Feb 28;289(9):5549-64. doi: 10.1074/jbc.M113.500405. Epub 2014 Jan 6.
PubMed
Associated Plasmids |
| Inhibition of stearoyl-coA desaturase selectively eliminates tumorigenic Nanog-positive cells: improving the safety of iPS cell transplantation to myocardium. Zhang L, Pan Y, Qin G, Chen L, Chatterjee TK, Weintraub NL, Tang Y. Cell Cycle. 2014;13(5):762-71. doi: 10.4161/cc.27677. Epub 2014 Jan 6. PubMed |
| microRNAs miR-27a and miR-27b directly regulate liver dihydropyrimidine dehydrogenase expression through two conserved binding sites. Offer SM, Butterfield GL, Jerde CR, Fossum CC, Wegner NJ, Diasio RB. Mol Cancer Ther. 2014 Mar;13(3):742-51. doi: 10.1158/1535-7163.MCT-13-0878. Epub 2014 Jan 8. PubMed |
| Dystrophin-deficient cardiomyocytes derived from human urine: new biologic reagents for drug discovery. Guan X, Mack DL, Moreno CM, Strande JL, Mathieu J, Shi Y, Markert CD, Wang Z, Liu G, Lawlor MW, Moorefield EC, Jones TN, Fugate JA, Furth ME, Murry CE, Ruohola-Baker H, Zhang Y, Santana LF, Childers MK. Stem Cell Res. 2014 Mar;12(2):467-80. doi: 10.1016/j.scr.2013.12.004. Epub 2013 Dec 23. PubMed |
| Gene delivery in malignant B cells using the combination of lentiviruses conjugated to anti-transferrin receptor antibodies and an immunoglobulin promoter. Leoh LS, Morizono K, Kershaw KM, Chen IS, Penichet ML, Daniels-Wells TR. J Gene Med. 2014 Jan-Feb;16(1-2):11-27. doi: 10.1002/jgm.2754. PubMed |
| CCN2 suppresses catabolic effects of interleukin-1beta through alpha5beta1 and alphaVbeta3 integrins in nucleus pulposus cells: implications in intervertebral disc degeneration. Tran CM, Schoepflin ZR, Markova DZ, Kepler CK, Anderson DG, Shapiro IM, Risbud MV. J Biol Chem. 2014 Mar 14;289(11):7374-87. doi: 10.1074/jbc.M113.526111. Epub 2014 Jan 24. PubMed |
| Oxysterol-binding protein is a phosphatidylinositol 4-kinase effector required for HCV replication membrane integrity and cholesterol trafficking. Wang H, Perry JW, Lauring AS, Neddermann P, De Francesco R, Tai AW. Gastroenterology. 2014 May;146(5):1373-85.e1-11. doi: 10.1053/j.gastro.2014.02.002. Epub 2014 Feb 8. PubMed |
| Importance of CD44 in the proliferation and mineralization of periodontal ligament cells. Yeh Y, Yang Y, Yuan K. J Periodontal Res. 2014 Dec;49(6):827-35. doi: 10.1111/jre.12170. Epub 2014 Feb 12. PubMed |
| Epstein-Barr virus utilizes Ikaros in regulating its latent-lytic switch in B cells. Iempridee T, Reusch JA, Riching A, Johannsen EC, Dovat S, Kenney SC, Mertz JE. J Virol. 2014 May;88(9):4811-27. doi: 10.1128/JVI.03706-13. Epub 2014 Feb 12. PubMed |
| Rapid cellular phenotyping of human pluripotent stem cell-derived cardiomyocytes using a genetically encoded fluorescent voltage sensor. Leyton-Mange JS, Mills RW, Macri VS, Jang MY, Butte FN, Ellinor PT, Milan DJ. Stem Cell Reports. 2014 Feb 6;2(2):163-70. doi: 10.1016/j.stemcr.2014.01.003. eCollection 2014 Feb 11. PubMed |
The PYRIN domain-only protein POP3 inhibits ALR inflammasomes and regulates responses to infection with DNA viruses.
Khare S, Ratsimandresy RA, de Almeida L, Cuda CM, Rellick SL, Misharin AV, Wallin MC, Gangopadhyay A, Forte E, Gottwein E, Perlman H, Reed JC, Greaves DR, Dorfleutner A, Stehlik C.
Nat Immunol. 2014 Apr;15(4):343-53. doi: 10.1038/ni.2829. Epub 2014 Feb 16.
PubMed
Associated Plasmids |
| deltaNp63 has a role in maintaining epithelial integrity in airway epithelium. Arason AJ, Jonsdottir HR, Halldorsson S, Benediktsdottir BE, Bergthorsson JT, Ingthorsson S, Baldursson O, Sinha S, Gudjonsson T, Magnusson MK. PLoS One. 2014 Feb 12;9(2):e88683. doi: 10.1371/journal.pone.0088683. eCollection 2014. PubMed |
| Cell adhesion molecules in metastatic neuroblastoma models. Schwankhaus N, Gathmann C, Wicklein D, Riecken K, Schumacher U, Valentiner U. Clin Exp Metastasis. 2014 Feb 19. PubMed |
Scaffold-mediated lentiviral transduction for functional tissue engineering of cartilage.
Brunger JM, Huynh NP, Guenther CM, Perez-Pinera P, Moutos FT, Sanchez-Adams J, Gersbach CA, Guilak F.
Proc Natl Acad Sci U S A. 2014 Mar 4;111(9):E798-806. doi: 10.1073/pnas.1321744111. Epub 2014 Feb 18.
PubMed
Associated Plasmids |
| Lentiviral vectors encoding zinc-finger nucleases specific for the model target locus HPRT1. Pelascini LP, Goncalves MA. Methods Mol Biol. 2014;1114:181-99. doi: 10.1007/978-1-62703-761-7_12. PubMed |
| Inhibition of mTORC1 induces loss of E-cadherin through AKT/GSK-3beta signaling-mediated upregulation of E-cadherin repressor complexes in non-small cell lung cancer cells. Kim EY, Kim A, Kim SK, Kim HJ, Chang J, Ahn CM, Chang YS. Respir Res. 2014 Feb 26;15:26. doi: 10.1186/1465-9921-15-26. PubMed |
| The Vac14-interaction network is linked to regulators of the endolysosomal and autophagic pathway. Schulze U, Vollenbroker B, Braun DA, Van Le T, Granado D, Kremerskothen J, Franzel B, Klosowski R, Barth J, Fufezan C, Wolters DA, Pavenstadt H, Weide T. Mol Cell Proteomics. 2014 Jun;13(6):1397-411. doi: 10.1074/mcp.M113.034108. Epub 2014 Feb 27. PubMed |
| Resistance to mTOR kinase inhibitors in lymphoma cells lacking 4EBP1. Mallya S, Fitch BA, Lee JS, So L, Janes MR, Fruman DA. PLoS One. 2014 Feb 21;9(2):e88865. doi: 10.1371/journal.pone.0088865. eCollection 2014. PubMed |
| Inhibition of TGFbeta signaling increases direct conversion of fibroblasts to induced cardiomyocytes. Ifkovits JL, Addis RC, Epstein JA, Gearhart JD. PLoS One. 2014 Feb 26;9(2):e89678. doi: 10.1371/journal.pone.0089678. eCollection 2014. PubMed |
| Cocaine disrupts histamine H3 receptor modulation of dopamine D1 receptor signaling: sigma1-D1-H3 receptor complexes as key targets for reducing cocaine's effects. Moreno E, Moreno-Delgado D, Navarro G, Hoffmann HM, Fuentes S, Rosell-Vilar S, Gasperini P, Rodriguez-Ruiz M, Medrano M, Mallol J, Cortes A, Casado V, Lluis C, Ferre S, Ortiz J, Canela E, McCormick PJ. J Neurosci. 2014 Mar 5;34(10):3545-58. doi: 10.1523/JNEUROSCI.4147-13.2014. PubMed |
| Production, purification and titration of a lentivirus-based vector for gene delivery purposes. Nasri M, Karimi A, Allahbakhshian Farsani M. Cytotechnology. 2014 Dec;66(6):1031-8. doi: 10.1007/s10616-013-9652-5. Epub 2014 Mar 6. PubMed |
| hCLE/C14orf166 associates with DDX1-HSPC117-FAM98B in a novel transcription-dependent shuttling RNA-transporting complex. Perez-Gonzalez A, Pazo A, Navajas R, Ciordia S, Rodriguez-Frandsen A, Nieto A. PLoS One. 2014 Mar 7;9(3):e90957. doi: 10.1371/journal.pone.0090957. eCollection 2014. PubMed |
| SAA1 polymorphisms are associated with variation in antiangiogenic and tumor-suppressive activities in nasopharyngeal carcinoma. Lung HL, Man OY, Yeung MC, Ko JM, Cheung AK, Law EW, Yu Z, Shuen WH, Tung E, Chan SH, Bangarusamy DK, Cheng Y, Yang X, Kan R, Phoon Y, Chan KC, Chua D, Kwong DL, Lee AW, Ji MF, Lung ML. Oncogene. 2015 Feb 12;34(7):878-89. doi: 10.1038/onc.2014.12. Epub 2014 Mar 10. PubMed |
| GP73 is upregulated by hepatitis C virus (HCV) infection and enhances HCV secretion. Hu L, Yao W, Wang F, Rong X, Peng T. PLoS One. 2014 Mar 7;9(3):e90553. doi: 10.1371/journal.pone.0090553. eCollection 2014. PubMed |
| Sphingosine Phosphate Lyase Regulates Murine Embryonic Stem Cell Proliferation and Pluripotency through an S1P/STAT3 Signaling Pathway. Smith GS, Kumar A, Saba JD. Biomolecules. 2013 Jun 24;3(3):351-368. PubMed |
| EMP1, a novel poor prognostic factor in pediatric leukemia regulates prednisolone resistance, cell proliferation, migration and adhesion. Aries IM, Jerchel IS, van den Dungen RE, van den Berk LC, Boer JM, Horstmann MA, Escherich G, Pieters R, den Boer ML. Leukemia. 2014 Sep;28(9):1828-37. doi: 10.1038/leu.2014.80. Epub 2014 Feb 20. PubMed |
| A protective antigen mutation increases the pH threshold of anthrax toxin receptor 2-mediated pore formation. Dennis MK, Mogridge J. Biochemistry. 2014 Apr 8;53(13):2166-71. doi: 10.1021/bi5000756. Epub 2014 Mar 25. PubMed |
| MiR-92a regulates viability and angiogenesis of endothelial cells under oxidative stress. Zhang L, Zhou M, Qin G, Weintraub NL, Tang Y. Biochem Biophys Res Commun. 2014 Apr 18;446(4):952-8. doi: 10.1016/j.bbrc.2014.03.035. Epub 2014 Mar 17. PubMed |
RPTPalpha controls epithelial adherens junctions, linking E-cadherin engagement to c-Src-mediated phosphorylation of cortactin.
Truffi M, Dubreuil V, Liang X, Vacaresse N, Nigon F, Han SP, Yap AS, Gomez GA, Sap J.
J Cell Sci. 2014 Jun 1;127(Pt 11):2420-32. doi: 10.1242/jcs.134379. Epub 2014 Mar 20.
PubMed
Associated Plasmids |
| Expressed glycosylphosphatidylinositol-anchored horseradish peroxidase identifies co-clustering molecules in individual lipid raft domains. Miyagawa-Yamaguchi A, Kotani N, Honke K. PLoS One. 2014 Mar 26;9(3):e93054. doi: 10.1371/journal.pone.0093054. eCollection 2014. PubMed |
| Evolutionary and molecular facts link the WWC protein family to Hippo signaling. Wennmann DO, Schmitz J, Wehr MC, Krahn MP, Koschmal N, Gromnitza S, Schulze U, Weide T, Chekuri A, Skryabin BV, Gerke V, Pavenstadt H, Duning K, Kremerskothen J. Mol Biol Evol. 2014 Jul;31(7):1710-23. doi: 10.1093/molbev/msu115. Epub 2014 Mar 27. PubMed |
| Myostatin knockdown and its effect on myogenic gene expression program in stably transfected goat myoblasts. Patel AK, Tripathi AK, Patel UA, Shah RK, Joshi CG. In Vitro Cell Dev Biol Anim. 2014 Aug;50(7):587-96. doi: 10.1007/s11626-014-9743-4. Epub 2014 Mar 28. PubMed |
| Activation of neural cell fate programs toward direct conversion of adult human fibroblasts into tri-potent neural progenitors using OCT-4. Mitchell RR, Szabo E, Benoit YD, Case DT, Mechael R, Alamilla J, Lee JH, Fiebig-Comyn A, Gillespie DC, Bhatia M. Stem Cells Dev. 2014 Aug 15;23(16):1937-46. doi: 10.1089/scd.2014.0023. Epub 2014 May 13. PubMed |
| Generation and characterization of induced pluripotent stem cells from Aid-deficient mice. Shimamoto R, Amano N, Ichisaka T, Watanabe A, Yamanaka S, Okita K. PLoS One. 2014 Apr 9;9(4):e94735. doi: 10.1371/journal.pone.0094735. eCollection 2014. PubMed |
| CDK2-dependent phosphorylation of Suv39H1 is involved in control of heterochromatin replication during cell cycle progression. Park SH, Yu SE, Chai YG, Jang YK. Nucleic Acids Res. 2014 Jun;42(10):6196-207. doi: 10.1093/nar/gku263. Epub 2014 Apr 11. PubMed |
| Evaluation of apoptosis induction by concomitant inhibition of MEK, mTOR, and Bcl-2 in human acute myelogenous leukemia cells. Zhang W, Ruvolo VR, Gao C, Zhou L, Bornmann W, Tsao T, Schober WD, Smith P, Guichard S, Konopleva M, Andreeff M. Mol Cancer Ther. 2014 Jul;13(7):1848-59. doi: 10.1158/1535-7163.MCT-13-0576. Epub 2014 Apr 16. PubMed |
| Pancreatic beta-cell failure mediated by mTORC1 hyperactivity and autophagic impairment. Bartolome A, Kimura-Koyanagi M, Asahara S, Guillen C, Inoue H, Teruyama K, Shimizu S, Kanno A, Garcia-Aguilar A, Koike M, Uchiyama Y, Benito M, Noda T, Kido Y. Diabetes. 2014 Sep;63(9):2996-3008. doi: 10.2337/db13-0970. Epub 2014 Apr 16. PubMed |
| "Triplet" polycistronic vectors encoding Gata4, Mef2c, and Tbx5 enhances postinfarct ventricular functional improvement compared with singlet vectors. Mathison M, Singh VP, Gersch RP, Ramirez MO, Cooney A, Kaminsky SM, Chiuchiolo MJ, Nasser A, Yang J, Crystal RG, Rosengart TK. J Thorac Cardiovasc Surg. 2014 Oct;148(4):1656-1664.e2. doi: 10.1016/j.jtcvs.2014.03.033. Epub 2014 Mar 27. PubMed |
| Tissue-engineered cartilage with inducible and tunable immunomodulatory properties. Glass KA, Link JM, Brunger JM, Moutos FT, Gersbach CA, Guilak F. Biomaterials. 2014 Jul;35(22):5921-31. doi: 10.1016/j.biomaterials.2014.03.073. Epub 2014 Apr 22. PubMed |
| Murine norovirus: propagation, quantification, and genetic manipulation. Hwang S, Alhatlani B, Arias A, Caddy SL, Christodoulou C, Cunha JB, Emmott E, Gonzalez-Hernandez M, Kolawole A, Lu J, Rippinger C, Sorgeloos F, Thorne L, Vashist S, Goodfellow I, Wobus CE. Curr Protoc Microbiol. 2014 May 1;33:15K.2.1-61. doi: 10.1002/9780471729259.mc15k02s33. PubMed |
| Impact of an altered PROX1 expression on clinicopathology, prognosis and progression in renal cell carcinoma. Lv T, Liu Y, Zhang J, Xu L, Zhu Y, Yin H, An H, Lin Z, Xie Y, Chen L. PLoS One. 2014 May 5;9(5):e95996. doi: 10.1371/journal.pone.0095996. eCollection 2014. PubMed |
| Polymerase I and transcript release factor (PTRF) regulates adipocyte differentiation and determines adipose tissue expandability. Perez-Diaz S, Johnson LA, DeKroon RM, Moreno-Navarrete JM, Alzate O, Fernandez-Real JM, Maeda N, Arbones-Mainar JM. FASEB J. 2014 Aug;28(8):3769-79. doi: 10.1096/fj.14-251165. Epub 2014 May 8. PubMed |
| New role for EMD (emerin), a key inner nuclear membrane protein, as an enhancer of autophagosome formation in the C16-ceramide autophagy pathway. Deroyer C, Renert AF, Merville MP, Fillet M. Autophagy. 2014 Jul;10(7):1229-40. doi: 10.4161/auto.28777. Epub 2014 May 7. PubMed |
| Long intergenic non-coding RNA HOTAIRM1 regulates cell cycle progression during myeloid maturation in NB4 human promyelocytic leukemia cells. Zhang X, Weissman SM, Newburger PE. RNA Biol. 2014;11(6):777-87. Epub 2014 Apr 24. PubMed |
| SIRT2 induces the checkpoint kinase BubR1 to increase lifespan. North BJ, Rosenberg MA, Jeganathan KB, Hafner AV, Michan S, Dai J, Baker DJ, Cen Y, Wu LE, Sauve AA, van Deursen JM, Rosenzweig A, Sinclair DA. EMBO J. 2014 Jul 1;33(13):1438-53. doi: 10.15252/embj.201386907. Epub 2014 May 12. PubMed |
| Quantitative proteomic analysis of host-virus interactions reveals a role for Golgi brefeldin A resistance factor 1 (GBF1) in dengue infection. Carpp LN, Rogers RS, Moritz RL, Aitchison JD. Mol Cell Proteomics. 2014 Nov;13(11):2836-54. doi: 10.1074/mcp.M114.038984. Epub 2014 May 22. PubMed |
| MST4 promotes hepatocellular carcinoma epithelial-mesenchymal transition and metastasis via activation of the p-ERK pathway. Lin ZH, Wang L, Zhang JB, Liu Y, Li XQ, Guo L, Zhang B, Zhu WW, Ye QH. Int J Oncol. 2014 Aug;45(2):629-40. doi: 10.3892/ijo.2014.2455. Epub 2014 May 22. PubMed |
| FIH-1-Mint3 axis does not control HIF-1 transcriptional activity in nucleus pulposus cells. Hirose Y, Johnson ZI, Schoepflin ZR, Markova DZ, Chiba K, Toyama Y, Shapiro IM, Risbud MV. J Biol Chem. 2014 Jul 25;289(30):20594-605. PubMed |
| Nrf2, a regulator of the proteasome, controls self-renewal and pluripotency in human embryonic stem cells. Jang J, Wang Y, Kim HS, Lalli MA, Kosik KS. Stem Cells. 2014 Oct;32(10):2616-25. doi: 10.1002/stem.1764. PubMed |
| Autophagy promotes resistance to photodynamic therapy-induced apoptosis selectively in colorectal cancer stem-like cells. Wei MF, Chen MW, Chen KC, Lou PJ, Lin SY, Hung SC, Hsiao M, Yao CJ, Shieh MJ. Autophagy. 2014 Jul;10(7):1179-92. doi: 10.4161/auto.28679. Epub 2014 Apr 29. PubMed |
| Molecular neuroimaging of post-injury plasticity. Jouroukhin Y, Nonyane BA, Gilad AA, Pelled G. J Mol Neurosci. 2014 Dec;54(4):630-8. doi: 10.1007/s12031-014-0347-y. Epub 2014 Jun 10. PubMed |
| Inhibition of glutathione peroxidase mediates the collateral sensitivity of multidrug-resistant cells to tiopronin. Hall MD, Marshall TS, Kwit AD, Miller Jenkins LM, Dulcey AE, Madigan JP, Pluchino KM, Goldsborough AS, Brimacombe KR, Griffiths GL, Gottesman MM. J Biol Chem. 2014 Aug 1;289(31):21473-89. doi: 10.1074/jbc.M114.581702. Epub 2014 Jun 14. PubMed |
| 17beta-estradiol regulates giant vesicle formation via estrogen receptor-alpha in human breast cancer cells. Wright PK, Jones SB, Ardern N, Ward R, Clarke RB, Sotgia F, Lisanti MP, Landberg G, Lamb R. Oncotarget. 2014 May 30;5(10):3055-65. PubMed |
| The prolyl peptidases PRCP/PREP regulate IRS-1 stability critical for rapamycin-induced feedback activation of PI3K and AKT. Duan L, Ying G, Danzer B, Perez RE, Shariat-Madar Z, Levenson VV, Maki CG. J Biol Chem. 2014 Aug 1;289(31):21694-705. doi: 10.1074/jbc.M114.550038. Epub 2014 Jun 16. PubMed |
| IL-17 and GM-CSF expression are antagonistically regulated by human T helper cells. Noster R, Riedel R, Mashreghi MF, Radbruch H, Harms L, Haftmann C, Chang HD, Radbruch A, Zielinski CE. Sci Transl Med. 2014 Jun 18;6(241):241ra80. doi: 10.1126/scitranslmed.3008706. PubMed |
Generation of mouse models of myeloid malignancy with combinatorial genetic lesions using CRISPR-Cas9 genome editing.
Heckl D, Kowalczyk MS, Yudovich D, Belizaire R, Puram RV, McConkey ME, Thielke A, Aster JC, Regev A, Ebert BL.
Nat Biotechnol. 2014 Jun 22. doi: 10.1038/nbt.2951.
PubMed
Associated Plasmids |
| Assessing the efficacy of nano- and micro-sized magnetic particles as contrast agents for MRI cell tracking. Taylor A, Herrmann A, Moss D, See V, Davies K, Williams SR, Murray P. PLoS One. 2014 Jun 24;9(6):e100259. doi: 10.1371/journal.pone.0100259. eCollection 2014. PubMed |
| Quantitative phosphoproteomics reveals novel phosphorylation events in insulin signaling regulated by protein phosphatase 1 regulatory subunit 12A. Zhang X, Ma D, Caruso M, Lewis M, Qi Y, Yi Z. J Proteomics. 2014 Sep 23;109:63-75. doi: 10.1016/j.jprot.2014.06.010. Epub 2014 Jun 25. PubMed |
| PKCzeta and PKMzeta are overexpressed in TCF3-rearranged paediatric acute lymphoblastic leukaemia and are associated with increased thiopurine sensitivity. Hartsink-Segers SA, Beaudoin JJ, Luijendijk MW, Exalto C, Pieters R, Den Boer ML. Leukemia. 2015 Feb;29(2):304-11. doi: 10.1038/leu.2014.210. Epub 2014 Jul 3. PubMed |
| ERbeta- and prostaglandin E2-regulated pathways integrate cell proliferation via Ras-like and estrogen-regulated growth inhibitor in endometriosis. Monsivais D, Dyson MT, Yin P, Coon JS, Navarro A, Feng G, Malpani SS, Ono M, Ercan CM, Wei JJ, Pavone ME, Su E, Bulun SE. Mol Endocrinol. 2014 Aug;28(8):1304-15. doi: 10.1210/me.2013-1421. Epub 2014 Jul 3. PubMed |
| Sirtuin1 (Sirt1) promotes cortical bone formation by preventing beta-catenin sequestration by FoxO transcription factors in osteoblast progenitors. Iyer S, Han L, Bartell SM, Kim HN, Gubrij I, de Cabo R, O'Brien CA, Manolagas SC, Almeida M. J Biol Chem. 2014 Aug 29;289(35):24069-78. doi: 10.1074/jbc.M114.561803. Epub 2014 Jul 7. PubMed |
| Par3-mInsc and Galphai3 cooperate to promote oriented epidermal cell divisions through LGN. Williams SE, Ratliff LA, Postiglione MP, Knoblich JA, Fuchs E. Nat Cell Biol. 2014 Aug;16(8):758-69. doi: 10.1038/ncb3001. Epub 2014 Jul 13. PubMed |
| Development of a lentivirus vector-based assay for non-destructive monitoring of cell fusion activity. Neshati Z, Liu J, Zhou G, Schalij MJ, de Vries AA. PLoS One. 2014 Jul 16;9(7):e102433. doi: 10.1371/journal.pone.0102433. eCollection 2014. PubMed |
| CREB SUMOylation by the E3 ligase PIAS1 enhances spatial memory. Chen YC, Hsu WL, Ma YL, Tai DJ, Lee EH. J Neurosci. 2014 Jul 16;34(29):9574-89. doi: 10.1523/JNEUROSCI.4302-13.2014. PubMed |
| Differential requirements of arrestin-3 and clathrin for ligand-dependent and -independent internalization of human G protein-coupled receptor 40. Qian J, Wu C, Chen X, Li X, Ying G, Jin L, Ma Q, Li G, Shi Y, Zhang G, Zhou N. Cell Signal. 2014 Nov;26(11):2412-23. doi: 10.1016/j.cellsig.2014.07.019. Epub 2014 Jul 16. PubMed |
| Oncogenic role of Merlin/NF2 in glioblastoma. Guerrero PA, Yin W, Camacho L, Marchetti D. Oncogene. 2015 May 14;34(20):2621-30. doi: 10.1038/onc.2014.185. Epub 2014 Jul 21. PubMed |
| Tumor necrosis factor-alpha- and interleukin-1beta-dependent matrix metalloproteinase-3 expression in nucleus pulposus cells requires cooperative signaling via syndecan 4 and mitogen-activated protein kinase-NF-kappaB axis: implications in inflammatory disc disease. Wang X, Wang H, Yang H, Li J, Cai Q, Shapiro IM, Risbud MV. Am J Pathol. 2014 Sep;184(9):2560-72. doi: 10.1016/j.ajpath.2014.06.006. Epub 2014 Jul 22. PubMed |
| A home-brew real-time PCR assay for reliable detection and quantification of mature miR-122. Naderi M, Abdul Tehrani H, Soleimani M, Shabani I, Hashemi SM. Appl Immunohistochem Mol Morphol. 2015 Sep;23(8):601-6. doi: 10.1097/PAI.0000000000000125. PubMed |
| Analysis of transcription factor network underlying 3T3-L1 adipocyte differentiation. Choi K, Ghaddar B, Moya C, Shi H, Sridharan GV, Lee K, Jayaraman A. PLoS One. 2014 Jul 30;9(7):e100177. doi: 10.1371/journal.pone.0100177. eCollection 2014. PubMed |
| SOX2 is a cancer-specific regulator of tumour initiating potential in cutaneous squamous cell carcinoma. Siegle JM, Basin A, Sastre-Perona A, Yonekubo Y, Brown J, Sennett R, Rendl M, Tsirigos A, Carucci JA, Schober M. Nat Commun. 2014 Jul 31;5:4511. doi: 10.1038/ncomms5511. PubMed |
| An essential role for the K+-dependent Na+/Ca2+-exchanger, NCKX4, in melanocortin-4-receptor-dependent satiety. Li XF, Lytton J. J Biol Chem. 2014 Sep 12;289(37):25445-59. doi: 10.1074/jbc.M114.564450. Epub 2014 Aug 5. PubMed |
| Porcine reproductive and respiratory syndrome virus counteracts the porcine intrinsic virus restriction factors-IFITM1 and Tetherin in MARC-145 cells. Wang X, Li C, Zhou L, Zhang N, Wang X, Ge X, Guo X, Yang H. Virus Res. 2014 Oct 13;191:92-100. doi: 10.1016/j.virusres.2014.07.025. Epub 2014 Aug 4. PubMed |
| An acetate switch regulates stress erythropoiesis. Xu M, Nagati JS, Xie J, Li J, Walters H, Moon YA, Gerard RD, Huang CL, Comerford SA, Hammer RE, Horton JD, Chen R, Garcia JA. Nat Med. 2014 Sep;20(9):1018-26. doi: 10.1038/nm.3587. Epub 2014 Aug 10. PubMed |
| Myeloid-specific disruption of tyrosine phosphatase Shp2 promotes alternative activation of macrophages and predisposes mice to pulmonary fibrosis. Tao B, Jin W, Xu J, Liang Z, Yao J, Zhang Y, Wang K, Cheng H, Zhang X, Ke Y. J Immunol. 2014 Sep 15;193(6):2801-11. doi: 10.4049/jimmunol.1303463. Epub 2014 Aug 15. PubMed |
| PGE2-induced colon cancer growth is mediated by mTORC1. Dufour M, Faes S, Dormond-Meuwly A, Demartines N, Dormond O. Biochem Biophys Res Commun. 2014 Sep 5;451(4):587-91. doi: 10.1016/j.bbrc.2014.08.032. Epub 2014 Aug 13. PubMed |
| The transcription factor FOXA2 suppresses gastric tumorigenesis in vitro and in vivo. Zhu CP, Wang J, Shi B, Hu PF, Ning BF, Zhang Q, Chen F, Chen WS, Zhang X, Xie WF. Dig Dis Sci. 2015 Jan;60(1):109-17. doi: 10.1007/s10620-014-3290-4. Epub 2014 Aug 17. PubMed |
| Human somatic cell mutagenesis creates genetically tractable sarcomas. Molyneux SD, Waterhouse PD, Shelton D, Shao YW, Watling CM, Tang QL, Harris IS, Dickson BC, Tharmapalan P, Sandve GK, Zhang X, Bailey SD, Berman H, Wunder JS, Izsvak Z, Lupien M, Mak TW, Khokha R. Nat Genet. 2014 Sep;46(9):964-72. doi: 10.1038/ng.3065. Epub 2014 Aug 17. PubMed |
| Complementation for an essential ancillary non-structural protein function across parvovirus genera. Mihaylov IS, Cotmore SF, Tattersall P. Virology. 2014 Nov;468-470:226-37. doi: 10.1016/j.virol.2014.07.043. Epub 2014 Sep 6. PubMed |
| IL4 limits the efficacy of tumor-targeted antibody therapy in a murine model. Surana R, Wang S, Xu W, Jablonski SA, Weiner LM. Cancer Immunol Res. 2014 Nov;2(11):1103-12. doi: 10.1158/2326-6066.CIR-14-0103. Epub 2014 Sep 9. PubMed |
| Spatial control of Cdc42 signalling by a GM130-RasGRF complex regulates polarity and tumorigenesis. Baschieri F, Confalonieri S, Bertalot G, Di Fiore PP, Dietmaier W, Leist M, Crespo P, Macara IG, Farhan H. Nat Commun. 2014 Sep 11;5:4839. doi: 10.1038/ncomms5839. PubMed |
| Interleukin-like epithelial-to-mesenchymal transition inducer activity is controlled by proteolytic processing and plasminogen-urokinase plasminogen activator receptor system-regulated secretion during breast cancer progression. Csiszar A, Kutay B, Wirth S, Schmidt U, Macho-Maschler S, Schreiber M, Alacakaptan M, Vogel GF, Aumayr K, Huber LA, Beug H. Breast Cancer Res. 2014 Sep 9;16(5):433. doi: 10.1186/s13058-014-0433-7. PubMed |
| CERS2 suppresses tumor cell invasion and is associated with decreased V-ATPase and MMP-2/MMP-9 activities in breast cancer. Fan SH, Wang YY, Lu J, Zheng YL, Wu DM, Zhang ZF, Shan Q, Hu B, Li MQ, Cheng W. J Cell Biochem. 2015 Apr;116(4):502-13. doi: 10.1002/jcb.24978. PubMed |
DDX3 DEAD-box RNA helicase is a host factor that restricts hepatitis B virus replication at the transcriptional level.
Ko C, Lee S, Windisch MP, Ryu WS.
J Virol. 2014 Dec;88(23):13689-98. doi: 10.1128/JVI.02035-14. Epub 2014 Sep 17.
PubMed
Associated Plasmids |
| Activation of the RIG-I pathway during influenza vaccination enhances the germinal center reaction, promotes T follicular helper cell induction, and provides a dose-sparing effect and protective immunity. Kulkarni RR, Rasheed MA, Bhaumik SK, Ranjan P, Cao W, Davis C, Marisetti K, Thomas S, Gangappa S, Sambhara S, Murali-Krishna K. J Virol. 2014 Dec;88(24):13990-4001. doi: 10.1128/JVI.02273-14. Epub 2014 Sep 24. PubMed |
| Bortezomib sensitizes primary meningioma cells to TRAIL-induced apoptosis by enhancing formation of the death-inducing signaling complex. Koschny R, Boehm C, Sprick MR, Haas TL, Holland H, Xu LX, Krupp W, Mueller WC, Bauer M, Koschny T, Keller M, Sinn P, Meixensberger J, Walczak H, Ganten TM. J Neuropathol Exp Neurol. 2014 Nov;73(11):1034-46. doi: 10.1097/NEN.0000000000000129. PubMed |
| A PTCH1 homolog transcriptionally activated by p53 suppresses Hedgehog signaling. Chung JH, Larsen AR, Chen E, Bunz F. J Biol Chem. 2014 Nov 21;289(47):33020-31. doi: 10.1074/jbc.M114.597203. Epub 2014 Oct 8. PubMed |
| The SNAI1 3'UTR functions as a sponge for multiple migration-/invasion-related microRNAs. Li J, Yu H, Xi M, Ma D, Lu X. Tumour Biol. 2015 Feb;36(2):1067-72. doi: 10.1007/s13277-014-2733-z. Epub 2014 Oct 19. PubMed |
| Vascular channels formed by subpopulations of PECAM1+ melanoma cells. Dunleavey JM, Xiao L, Thompson J, Kim MM, Shields JM, Shelton SE, Irvin DM, Brings VE, Ollila DW, Brekken RA, Dayton PA, Melero-Martin JM, Dudley AC. Nat Commun. 2014 Oct 22;5:5200. doi: 10.1038/ncomms6200. PubMed |
| Robo4 vaccines induce antibodies that retard tumor growth. Zhuang X, Ahmed F, Zhang Y, Ferguson HJ, Steele JC, Steven NM, Nagy Z, Heath VL, Toellner KM, Bicknell R. Angiogenesis. 2015 Jan;18(1):83-95. doi: 10.1007/s10456-014-9448-z. Epub 2014 Oct 28. PubMed |
| Functional analysis of prognostic gene expression network genes in metastatic breast cancer models. Geiger TR, Ha NH, Faraji F, Michael HT, Rodriguez L, Walker RC, Green JE, Simpson RM, Hunter KW. PLoS One. 2014 Nov 4;9(11):e111813. doi: 10.1371/journal.pone.0111813. eCollection 2014. PubMed |
| The protein phosphatase 2A inhibitor LB100 sensitizes ovarian carcinoma cells to cisplatin-mediated cytotoxicity. Chang KE, Wei BR, Madigan JP, Hall MD, Simpson RM, Zhuang Z, Gottesman MM. Mol Cancer Ther. 2015 Jan;14(1):90-100. doi: 10.1158/1535-7163.MCT-14-0496. Epub 2014 Nov 5. PubMed |
| The Hippo pathway is controlled by Angiotensin II signaling and its reactivation induces apoptosis in podocytes. Wennmann DO, Vollenbroker B, Eckart AK, Bonse J, Erdmann F, Wolters DA, Schenk LK, Schulze U, Kremerskothen J, Weide T, Pavenstadt H. Cell Death Dis. 2014 Nov 13;5:e1519. doi: 10.1038/cddis.2014.476. PubMed |
| Stable suppression of myostatin gene expression in goat fetal fibroblast cells by lentiviral vector-mediated RNAi. Patel UA, Patel AK, Joshi CG. Biotechnol Prog. 2015 Mar;31(2):452-9. doi: 10.1002/btpr.2022. Epub 2014 Nov 24. PubMed |
| Inhibition of class I HDACs abrogates the dominant effect of MLL-AF4 by activation of wild-type MLL. Ahmad K, Katryniok C, Scholz B, Merkens J, Loscher D, Marschalek R, Steinhilber D. Oncogenesis. 2014 Nov 17;3:e127. doi: 10.1038/oncsis.2014.39. PubMed |
| MNKs act as a regulatory switch for eIF4E1 and eIF4E3 driven mRNA translation in DLBCL. Landon AL, Muniandy PA, Shetty AC, Lehrmann E, Volpon L, Houng S, Zhang Y, Dai B, Peroutka R, Mazan-Mamczarz K, Steinhardt J, Mahurkar A, Becker KG, Borden KL, Gartenhaus RB. Nat Commun. 2014 Nov 18;5:5413. doi: 10.1038/ncomms6413. PubMed |
| Silencing long noncoding RNAs with genome-editing tools. Gutschner T. Methods Mol Biol. 2015;1239:241-50. doi: 10.1007/978-1-4939-1862-1_13. PubMed |
| Andes virus nucleocapsid protein interrupts protein kinase R dimerization to counteract host interference in viral protein synthesis. Wang Z, Mir MA. J Virol. 2015 Feb;89(3):1628-39. doi: 10.1128/JVI.02347-14. Epub 2014 Nov 19. PubMed |
| Prediction and quantification of bioactive microbiota metabolites in the mouse gut. Sridharan GV, Choi K, Klemashevich C, Wu C, Prabakaran D, Pan LB, Steinmeyer S, Mueller C, Yousofshahi M, Alaniz RC, Lee K, Jayaraman A. Nat Commun. 2014 Nov 20;5:5492. doi: 10.1038/ncomms6492. PubMed |
| Inhibition of autophagy as a new means of improving chemotherapy efficiency in high-LC3B triple-negative breast cancers. Lefort S, Joffre C, Kieffer Y, Givel AM, Bourachot B, Zago G, Bieche I, Dubois T, Meseure D, Vincent-Salomon A, Camonis J, Mechta-Grigoriou F. Autophagy. 2014;10(12):2122-42. doi: 10.4161/15548627.2014.981788. PubMed |
| Mitochondrial DNA haplogroup B5 confers genetic susceptibility to Alzheimer's disease in Han Chinese. Bi R, Zhang W, Yu D, Li X, Wang HZ, Hu QX, Zhang C, Lu W, Ni J, Fang Y, Li T, Yao YG. Neurobiol Aging. 2015 Mar;36(3):1604.e7-16. doi: 10.1016/j.neurobiolaging.2014.10.009. Epub 2014 Oct 22. PubMed |
| Deficiency in the mitochondrial apoptotic pathway reveals the toxic potential of autophagy under ER stress conditions. Deegan S, Saveljeva S, Logue SE, Pakos-Zebrucka K, Gupta S, Vandenabeele P, Bertrand MJ, Samali A. Autophagy. 2014;10(11):1921-36. doi: 10.4161/15548627.2014.981790. PubMed |
| Xylosyltransferase-1 expression is refractory to inhibition by the inflammatory cytokines tumor necrosis factor alpha and IL-1beta in nucleus pulposus cells: novel regulation by AP-1, Sp1, and Sp3. Ye W, Zhou J, Markova DZ, Tian Y, Li J, Anderson DG, Shapiro IM, Risbud MV. Am J Pathol. 2015 Feb;185(2):485-95. doi: 10.1016/j.ajpath.2014.09.021. Epub 2014 Dec 2. PubMed |
| Increasing cisplatin sensitivity by schedule-dependent inhibition of AKT and Chk1. Duan L, Perez RE, Hansen M, Gitelis S, Maki CG. Cancer Biol Ther. 2014;15(12):1600-12. doi: 10.4161/15384047.2014.961876. PubMed |
| Dysregulated autophagy in the RPE is associated with increased susceptibility to oxidative stress and AMD. Mitter SK, Song C, Qi X, Mao H, Rao H, Akin D, Lewin A, Grant M, Dunn W Jr, Ding J, Bowes Rickman C, Boulton M. Autophagy. 2014;10(11):1989-2005. doi: 10.4161/auto.36184. PubMed |
| c-Src deactivation by the polyphenol 3-O-caffeoylquinic acid abrogates reactive oxygen species-mediated glutamate release from microglia and neuronal excitotoxicity. Socodato R, Portugal CC, Canedo T, Domith I, Oliveira NA, Paes-de-Carvalho R, Relvas JB, Cossenza M. Free Radic Biol Med. 2015 Feb;79:45-55. doi: 10.1016/j.freeradbiomed.2014.11.019. Epub 2014 Dec 5. PubMed |
| The neutral sphingomyelinase pathway regulates packaging of the prion protein into exosomes. Guo BB, Bellingham SA, Hill AF. J Biol Chem. 2015 Feb 6;290(6):3455-67. doi: 10.1074/jbc.M114.605253. Epub 2014 Dec 10. PubMed |
| A Phospho-SIM in the Antiviral Protein PML is Required for Its Recruitment to HSV-1 Genomes. Smith MC, Box AC, Haug JS, Lane WS, Davido DJ. Cells. 2014 Dec 10;3(4):1131-58. doi: 10.3390/cells3041131. PubMed |
| Knockdown of the Cell Cycle Inhibitor p21 Enhances Cartilage Formation by Induced Pluripotent Stem Cells. Diekman BO, Thakore PI, O'Connor SK, Willard VP, Brunger JM, Christoforou N, Leong KW, Gersbach CA, Guilak F. Tissue Eng Part A. 2015 Apr;21(7-8):1261-74. doi: 10.1089/ten.TEA.2014.0240. Epub 2015 Jan 23. PubMed |
| Targeting the effector domain of the myristoylated alanine rich C-kinase substrate enhances lung cancer radiation sensitivity. Rohrbach TD, Jarboe JS, Anderson JC, Trummell HQ, Hicks PH, Weaver AN, Yang ES, Oster RA, Deshane JS, Steele C, Siegal GP, Bonner JA, Willey CD. Int J Oncol. 2015 Mar;46(3):1079-88. doi: 10.3892/ijo.2014.2799. Epub 2014 Dec 17. PubMed |
| Reversal of Mutant KRAS-Mediated Apoptosis Resistance by Concurrent Noxa/Bik Induction and Bcl-2/Bcl-xL Antagonism in Colon Cancer Cells. Okamoto K, Zaanan A, Kawakami H, Huang S, Sinicrope FA. Mol Cancer Res. 2015 Apr;13(4):659-69. doi: 10.1158/1541-7786.MCR-14-0476. Epub 2014 Dec 29. PubMed |
| Inhibition of autophagic turnover in beta-cells by fatty acids and glucose leads to apoptotic cell death. Mir SU, George NM, Zahoor L, Harms R, Guinn Z, Sarvetnick NE. J Biol Chem. 2015 Mar 6;290(10):6071-85. doi: 10.1074/jbc.M114.605345. Epub 2014 Dec 29. PubMed |
| Role of the clathrin adaptor PICALM in normal hematopoiesis and polycythemia vera pathophysiology. Ishikawa Y, Maeda M, Pasham M, Aguet F, Tacheva-Grigorova SK, Masuda T, Yi H, Lee SU, Xu J, Teruya-Feldstein J, Ericsson M, Mullally A, Heuser J, Kirchhausen T, Maeda T. Haematologica. 2015 Apr;100(4):439-51. doi: 10.3324/haematol.2014.119537. Epub 2014 Dec 31. PubMed |
| Endoplasmic reticulum stress induces ligand-independent TNFR1-mediated necroptosis in L929 cells. Saveljeva S, Mc Laughlin SL, Vandenabeele P, Samali A, Bertrand MJ. Cell Death Dis. 2015 Jan 8;6:e1587. doi: 10.1038/cddis.2014.548. PubMed |
| Filamin C, a dysregulated protein in cancer revealed by label-free quantitative proteomic analyses of human gastric cancer cells. Qiao J, Cui SJ, Xu LL, Chen SJ, Yao J, Jiang YH, Peng G, Fang CY, Yang PY, Liu F. Oncotarget. 2015 Jan 20;6(2):1171-89. PubMed |
| Expression of the potential therapeutic target CXXC5 in primary acute myeloid leukemia cells - high expression is associated with adverse prognosis as well as altered intracellular signaling and transcriptional regulation. Bruserud O, Reikvam H, Fredly H, Skavland J, Hagen KM, van Hoang TT, Brenner AK, Kadi A, Astori A, Gjertsen BT, Pendino F. Oncotarget. 2015 Feb 20;6(5):2794-811. PubMed |
| A novel cytostatic form of autophagy in sensitization of non-small cell lung cancer cells to radiation by vitamin D and the vitamin D analog, EB 1089. Sharma K, Goehe RW, Di X, Hicks MA 2nd, Torti SV, Torti FM, Harada H, Gewirtz DA. Autophagy. 2014;10(12):2346-61. doi: 10.4161/15548627.2014.993283. PubMed |
| Prolyl-4-hydroxylase domain protein 2 controls NF-kappaB/p65 transactivation and enhances the catabolic effects of inflammatory cytokines on cells of the nucleus pulposus. Li J, Yuan W, Jiang S, Ye W, Yang H, Shapiro IM, Risbud MV. J Biol Chem. 2015 Mar 13;290(11):7195-207. doi: 10.1074/jbc.M114.611483. Epub 2015 Jan 29. PubMed |
| YAP-mediated induction of monoacylglycerol lipase restrains oncogenic transformation. Tang ED, Wang CY. Cell Signal. 2015 Apr;27(4):836-40. doi: 10.1016/j.cellsig.2015.01.011. Epub 2015 Jan 28. PubMed |
| UBE3C promotes growth and metastasis of renal cell carcinoma via activating Wnt/beta-catenin pathway. Wen JL, Wen XF, Li RB, Jin YC, Wang XL, Zhou L, Chen HX. PLoS One. 2015 Feb 6;10(2):e0115622. doi: 10.1371/journal.pone.0115622. eCollection 2015. PubMed |
| The inhibitory effects of anacardic acid on hepatitis C virus life cycle. Hundt J, Li Z, Liu Q. PLoS One. 2015 Feb 6;10(2):e0117514. doi: 10.1371/journal.pone.0117514. eCollection 2015. PubMed |
| DNA damage-induced regulatory interplay between DAXX, p53, ATM kinase and Wip1 phosphatase. Brazina J, Svadlenka J, Macurek L, Andera L, Hodny Z, Bartek J, Hanzlikova H. Cell Cycle. 2015;14(3):375-87. doi: 10.4161/15384101.2014.988019. PubMed |
| Lysyl hydroxylase 2 induces a collagen cross-link switch in tumor stroma. Chen Y, Terajima M, Yang Y, Sun L, Ahn YH, Pankova D, Puperi DS, Watanabe T, Kim MP, Blackmon SH, Rodriguez J, Liu H, Behrens C, Wistuba II, Minelli R, Scott KL, Sanchez-Adams J, Guilak F, Pati D, Thilaganathan N, Burns AR, Creighton CJ, Martinez ED, Zal T, Grande-Allen KJ, Yamauchi M, Kurie JM. J Clin Invest. 2015 Mar 2;125(3):1147-62. doi: 10.1172/JCI74725. Epub 2015 Feb 9. PubMed |
| The functional interactome of PYHIN immune regulators reveals IFIX is a sensor of viral DNA. Diner BA, Li T, Greco TM, Crow MS, Fuesler JA, Wang J, Cristea IM. Mol Syst Biol. 2015 Feb 9;11(1):787. doi: 10.15252/msb.20145808. PubMed |
| PROX1 promotes hepatocellular carcinoma proliferation and sorafenib resistance by enhancing beta-catenin expression and nuclear translocation. Liu Y, Ye X, Zhang JB, Ouyang H, Shen Z, Wu Y, Wang W, Wu J, Tao S, Yang X, Qiao K, Zhang J, Liu J, Fu Q, Xie Y. Oncogene. 2015 Feb 16. doi: 10.1038/onc.2015.7. PubMed |
| mTORC1 upregulation via ERK-dependent gene expression change confers intrinsic resistance to MEK inhibitors in oncogenic KRas-mutant cancer cells. Komatsu N, Fujita Y, Matsuda M, Aoki K. Oncogene. 2015 Feb 23. doi: 10.1038/onc.2015.16. PubMed |
| Cryopreservation of microencapsulated murine mesenchymal stem cells genetically engineered to secrete erythropoietin. Gurruchaga H, Ciriza J, Saenz Del Burgo L, Rodriguez-Madoz JR, Santos E, Prosper F, Hernandez RM, Orive G, Pedraz JL. Int J Pharm. 2015 May 15;485(1-2):15-24. doi: 10.1016/j.ijpharm.2015.02.047. Epub 2015 Feb 20. PubMed |
| ICAM1 depletion reduces spinal metastasis formation in vivo and improves neurological outcome. Broggini T, Czabanka M, Piffko A, Harms C, Hoffmann C, Mrowka R, Wenke F, Deutsch U, Grotzinger C, Vajkoczy P. Eur Spine J. 2015 Feb 25. PubMed |
Novel lentiviral-inducible transgene expression systems and versatile single-plasmid reporters for in vitro and in vivo cancer biology studies.
Shuen WH, Kan R, Yu Z, Lung HL, Lung ML.
Cancer Gene Ther. 2015 Feb 27. doi: 10.1038/cgt.2015.9.
PubMed
Associated Plasmids |
Highly efficient Cas9-mediated transcriptional programming.
Chavez A, Scheiman J, Vora S, Pruitt BW, Tuttle M, P R Iyer E, Lin S, Kiani S, Guzman CD, Wiegand DJ, Ter-Ovanesyan D, Braff JL, Davidsohn N, Housden BE, Perrimon N, Weiss R, Aach J, Collins JJ, Church GM.
Nat Methods. 2015 Mar 2. doi: 10.1038/nmeth.3312.
PubMed
Associated Plasmids |
| Fatty acid elongase 7 catalyzes lipidome remodeling essential for human cytomegalovirus replication. Purdy JG, Shenk T, Rabinowitz JD. Cell Rep. 2015 Mar 3;10(8):1375-85. doi: 10.1016/j.celrep.2015.02.003. Epub 2015 Feb 26. PubMed |
| Stemness factor Sall4 is required for DNA damage response in embryonic stem cells. Xiong J, Todorova D, Su NY, Kim J, Lee PJ, Shen Z, Briggs SP, Xu Y. J Cell Biol. 2015 Mar 2;208(5):513-20. doi: 10.1083/jcb.201408106. PubMed |
| Rad51-mediated replication fork reversal is a global response to genotoxic treatments in human cells. Zellweger R, Dalcher D, Mutreja K, Berti M, Schmid JA, Herrador R, Vindigni A, Lopes M. J Cell Biol. 2015 Mar 2;208(5):563-79. doi: 10.1083/jcb.201406099. PubMed |
| CD47 agonist peptides induce programmed cell death in refractory chronic lymphocytic leukemia B cells via PLCgamma1 activation: evidence from mice and humans. Martinez-Torres AC, Quiney C, Attout T, Boullet H, Herbi L, Vela L, Barbier S, Chateau D, Chapiro E, Nguyen-Khac F, Davi F, Le Garff-Tavernier M, Moumne R, Sarfati M, Karoyan P, Merle-Beral H, Launay P, Susin SA. PLoS Med. 2015 Mar 3;12(3):e1001796. doi: 10.1371/journal.pmed.1001796. eCollection 2015 Mar. PubMed |
| DNA damage shifts circadian clock time via Hausp-dependent Cry1 stabilization. Papp SJ, Huber AL, Jordan SD, Kriebs A, Nguyen M, Moresco JJ, Yates JR, Lamia KA. Elife. 2015 Mar 10;4. doi: 10.7554/eLife.04883. PubMed |
Plexin-B2 promotes invasive growth of malignant glioma.
Le AP, Huang Y, Pingle SC, Kesari S, Wang H, Yong RL, Zou H, Friedel RH.
Oncotarget. 2015 Mar 30;6(9):7293-304.
PubMed
Associated Plasmids |
| Interleukin 6 inhibits HBV entry through NTCP down regulation. Bouezzedine F, Fardel O, Gripon P. Virology. 2015 Jul;481:34-42. doi: 10.1016/j.virol.2015.02.026. Epub 2015 Mar 9. PubMed |
| Selective Distal Enhancer Control of the Mmp13 Gene Identified through Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR) Genomic Deletions. Meyer MB, Benkusky NA, Pike JW. J Biol Chem. 2015 Apr 24;290(17):11093-107. doi: 10.1074/jbc.M115.648394. Epub 2015 Mar 15. PubMed |
| IFI44 suppresses HIV-1 LTR promoter activity and facilitates its latency. Power D, Santoso N, Dieringer M, Yu J, Huang H, Simpson S, Seth I, Miao H, Zhu J. Virology. 2015 Jul;481:142-50. doi: 10.1016/j.virol.2015.02.046. Epub 2015 Mar 14. PubMed |
| miR-191 promotes tumorigenesis of human colorectal cancer through targeting C/EBPbeta. Zhang XF, Li KK, Gao L, Li SZ, Chen K, Zhang JB, Wang D, Tu RF, Zhang JX, Tao KX, Wang G, Zhang XD. Oncotarget. 2015 Feb 28;6(6):4144-58. PubMed |
| Modeling and study of the mechanism of dilated cardiomyopathy using induced pluripotent stem cells derived from individuals with Duchenne muscular dystrophy. Lin B, Li Y, Han L, Kaplan AD, Ao Y, Kalra S, Bett GC, Rasmusson RL, Denning C, Yang L. Dis Model Mech. 2015 May;8(5):457-66. doi: 10.1242/dmm.019505. Epub 2015 Mar 19. PubMed |
| Borna disease virus phosphoprotein modulates epigenetic signaling in neurons to control viral replication. Bonnaud EM, Szelechowski M, Betourne A, Foret C, Thouard A, Gonzalez-Dunia D, Malnou CE. J Virol. 2015 Jun;89(11):5996-6008. doi: 10.1128/JVI.00454-15. Epub 2015 Mar 25. PubMed |
| CCM2-CCM3 interaction stabilizes their protein expression and permits endothelial network formation. Draheim KM, Li X, Zhang R, Fisher OS, Villari G, Boggon TJ, Calderwood DA. J Cell Biol. 2015 Mar 30;208(7):987-1001. doi: 10.1083/jcb.201407129. PubMed |
| Identification and characterization of nonhistone chromatin proteins: human positive coactivator 4 as a candidate. Kumari S, Das C, Sikder S, Kumar M, Bachu M, Ranga U, Kundu TK. Methods Mol Biol. 2015;1288:245-72. doi: 10.1007/978-1-4939-2474-5_14. PubMed |
| TGF-beta suppression of HBV RNA through AID-dependent recruitment of an RNA exosome complex. Liang G, Liu G, Kitamura K, Wang Z, Chowdhury S, Monjurul AM, Wakae K, Koura M, Shimadu M, Kinoshita K, Muramatsu M. PLoS Pathog. 2015 Apr 2;11(4):e1004780. doi: 10.1371/journal.ppat.1004780. eCollection 2015 Apr. PubMed |
| Caveolin-1 is transcribed from a hypermethylated promoter to mediate colonocyte differentiation and apoptosis. Dasgupta N, Kumar Thakur B, Ta A, Das S. Exp Cell Res. 2015 Jun 10;334(2):323-36. doi: 10.1016/j.yexcr.2015.03.020. Epub 2015 Apr 1. PubMed |
| Latent transforming growth factor-beta binding proteins (LTBP-1 and LTBP-2) and gingiva keratinization. Chiang MS, Yang JR, Liao SC, Hsu CC, Hsu CW, Yuan K. Oral Dis. 2015 Apr 10. doi: 10.1111/odi.12344. PubMed |
| The DNA helicase recql4 is required for normal osteoblast expansion and osteosarcoma formation. Ng AJ, Walia MK, Smeets MF, Mutsaers AJ, Sims NA, Purton LE, Walsh NC, Martin TJ, Walkley CR. PLoS Genet. 2015 Apr 10;11(4):e1005160. doi: 10.1371/journal.pgen.1005160. eCollection 2015 Apr. PubMed |
| Methods of Reprogramming to Induced Pluripotent Stem Cell Associated with Chromosomal Integrity and Delineation of a Chromosome 5q Candidate Region for Growth Advantage. Sobol M, Raykova D, Cavelier L, Khalfallah A, Schuster J, Dahl N. Stem Cells Dev. 2015 Sep 1;24(17):2032-40. doi: 10.1089/scd.2015.0061. Epub 2015 May 18. PubMed |
| A pooled shRNA screen for regulators of primary mammary stem and progenitor cells identifies roles for Asap1 and Prox1. Sheridan JM, Ritchie ME, Best SA, Jiang K, Beck TJ, Vaillant F, Liu K, Dickins RA, Smyth GK, Lindeman GJ, Visvader JE. BMC Cancer. 2015 Apr 3;15:221. doi: 10.1186/s12885-015-1187-z. PubMed |
| Loss of GM130 in breast cancer cells and its effects on cell migration, invasion and polarity. Baschieri F, Uetz-von Allmen E, Legler DF, Farhan H. Cell Cycle. 2015;14(8):1139-47. doi: 10.1080/15384101.2015.1007771. PubMed |
| Quantification of cell fusion events human breast cancer cells and breast epithelial cells using a Cre-LoxP-based double fluorescence reporter system. Mohr M, Tosun S, Arnold WH, Edenhofer F, Zanker KS, Dittmar T. Cell Mol Life Sci. 2015 Apr 22. PubMed |
| Cellular metabolism of unnatural sialic acid precursors. Pham ND, Fermaintt CS, Rodriguez AC, McCombs JE, Nischan N, Kohler JJ. Glycoconj J. 2015 May 10. PubMed |
| Overexpression of the Promigratory and Prometastatic PTK7 Receptor Is Associated with an Adverse Clinical Outcome in Colorectal Cancer. Lhoumeau AC, Martinez S, Boher JM, Monges G, Castellano R, Goubard A, Doremus M, Poizat F, Lelong B, de Chaisemartin C, Bardin F, Viens P, Raoul JL, Prebet T, Aurrand-Lions M, Borg JP, Goncalves A. PLoS One. 2015 May 11;10(5):e0123768. doi: 10.1371/journal.pone.0123768. eCollection 2015. PubMed |
| Inhibition of histone methyltransferases SUV39H1 and G9a leads to neuroprotection in an in vitro model of cerebral ischemia. Schweizer S, Harms C, Lerch H, Flynn J, Hecht J, Yildirim F, Meisel A, Marschenz S. J Cereb Blood Flow Metab. 2015 May 13. doi: 10.1038/jcbfm.2015.99. PubMed |
| Reduced efficiency of sarcolipin-dependent respiration in myocytes from humans with severe obesity. Paran CW, Verkerke AR, Heden TD, Park S, Zou K, Lawson HA, Song H, Turk J, Houmard JA, Funai K. Obesity (Silver Spring). 2015 Jul;23(7):1440-9. doi: 10.1002/oby.21123. Epub 2015 May 13. PubMed |
| Regulation of autophagic cell death by glycogen synthase kinase-3beta in adult hippocampal neural stem cells following insulin withdrawal. Ha S, Ryu HY, Chung KM, Baek SH, Kim EK, Yu SW. Mol Brain. 2015 May 19;8:30. doi: 10.1186/s13041-015-0119-9. PubMed |
| Death of Neurons following Injury Requires Conductive Neuronal Gap Junction Channels but Not a Specific Connexin. Fontes JD, Ramsey J, Polk JM, Koop A, Denisova JV, Belousov AB. PLoS One. 2015 May 27;10(5):e0125395. doi: 10.1371/journal.pone.0125395. eCollection 2015. PubMed |
| Human Induced Pluripotent Stem Cell-Derived Microvesicles Transmit RNAs and Proteins to Recipient Mature Heart Cells Modulating Cell Fate and Behavior. Bobis-Wozowicz S, Kmiotek K, Sekula M, Kedracka-Krok S, Kamycka E, Adamiak M, Jankowska U, Madetko-Talowska A, Sarna M, Bik-Multanowski M, Kolcz J, Boruczkowski D, Madeja Z, Dawn B, Zuba-Surma EK. Stem Cells. 2015 Jun 1. doi: 10.1002/stem.2078. PubMed |
| E2F1-Mediated Induction of NFYB Attenuates Apoptosis via Joint Regulation of a Pro-Survival Transcriptional Program. Jiang X, Nevins JR, Shats I, Chi JT. PLoS One. 2015 Jun 3;10(6):e0127951. doi: 10.1371/journal.pone.0127951. eCollection 2015. PubMed |
| Lentiviral transduction of mammary epithelial cells. Iggo R, Richard E. Methods Mol Biol. 2015;1293:137-60. doi: 10.1007/978-1-4939-2519-3_8. PubMed |
| Reprogramming fibroblasts toward cardiomyocytes, neural stem cells and hepatocytes by cell activation and signaling-directed lineage conversion. Zhu S, Wang H, Ding S. Nat Protoc. 2015 Jul;10(7):959-73. doi: 10.1038/nprot.2015.059. Epub 2015 Jun 4. PubMed |
| CRISPR-Cas9-mediated gene knockout in primary human airway epithelial cells reveals a proinflammatory role for MUC18. Chu HW, Rios C, Huang C, Wesolowska-Andersen A, Burchard EG, O'Connor BP, Fingerlin TE, Nichols D, Reynolds SD, Seibold MA. Gene Ther. 2015 Jul 2. doi: 10.1038/gt.2015.53. PubMed |
| Forward Programming of Cardiac Stem Cells by Homogeneous Transduction with MYOCD plus TBX5. Belian E, Noseda M, Abreu Paiva MS, Leja T, Sampson R, Schneider MD. PLoS One. 2015 Jun 5;10(6):e0125384. doi: 10.1371/journal.pone.0125384. eCollection 2015. PubMed |
| Evidence that synthetic lethality underlies the mutual exclusivity of oncogenic KRAS and EGFR mutations in lung adenocarcinoma. Unni AM, Lockwood WW, Zejnullahu K, Lee-Lin SQ, Varmus H. Elife. 2015 Jun 5;4:e06907. doi: 10.7554/eLife.06907. PubMed |
| Decoy receptors block TRAIL sensitivity at a supracellular level: the role of stromal cells in controlling tumour TRAIL sensitivity. O'Leary L, van der Sloot AM, Reis CR, Deegan S, Ryan AE, Dhami SP, Murillo LS, Cool RH, de Sampaio PC, Thompson K, Murphy G, Quax WJ, Serrano L, Samali A, Szegezdi E. Oncogene. 2015 Jun 8. doi: 10.1038/onc.2015.180. PubMed |
| Tryptophan derivatives regulate the transcription of Oct4 in stem-like cancer cells. Cheng J, Li W, Kang B, Zhou Y, Song J, Dan S, Yang Y, Zhang X, Li J, Yin S, Cao H, Yao H, Zhu C, Yi W, Zhao Q, Xu X, Zheng M, Zheng S, Li L, Shen B, Wang YJ. Nat Commun. 2015 Jun 10;6:7209. doi: 10.1038/ncomms8209. PubMed |
| Lysine-specific demethylase (LSD1/KDM1A) and MYCN cooperatively repress tumor suppressor genes in neuroblastoma. Amente S, Milazzo G, Sorrentino MC, Ambrosio S, Di Palo G, Lania L, Perini G, Majello B. Oncotarget. 2015 Jun 10;6(16):14572-83. PubMed |
| Regulation of vascular endothelial growth factor receptor function in angiogenesis by numb and numb-like. van Lessen M, Nakayama M, Kato K, Kim JM, Kaibuchi K, Adams RH. Arterioscler Thromb Vasc Biol. 2015 Aug;35(8):1815-25. doi: 10.1161/ATVBAHA.115.305473. Epub 2015 Jun 11. PubMed |
| Transcriptional co-factor Transducin beta-like (TBL) 1 acts as a checkpoint in pancreatic cancer malignancy. Stoy C, Sundaram A, Rios Garcia M, Wang X, Seibert O, Zota A, Wendler S, Mannle D, Hinz U, Sticht C, Muciek M, Gretz N, Rose AJ, Greiner V, Hofmann TG, Bauer A, Hoheisel J, Berriel Diaz M, Gaida MM, Werner J, Schafmeier T, Strobel O, Herzig S. EMBO Mol Med. 2015 Jun 12;7(8):1048-62. doi: 10.15252/emmm.201404837. PubMed |
| Parkinson-causing alpha-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation. Dettmer U, Newman AJ, Soldner F, Luth ES, Kim NC, von Saucken VE, Sanderson JB, Jaenisch R, Bartels T, Selkoe D. Nat Commun. 2015 Jun 16;6:7314. doi: 10.1038/ncomms8314. PubMed |
| Lhx8 mediated Wnt and TGFbeta pathways in tooth development and regeneration. Zhou C, Yang G, Chen M, Wang C, He L, Xiang L, Chen D, Ling J, Mao JJ. Biomaterials. 2015 Sep;63:35-46. doi: 10.1016/j.biomaterials.2015.06.004. Epub 2015 Jun 3. PubMed |
| Binding of the sphingolipid S1P to hTERT stabilizes telomerase at the nuclear periphery by allosterically mimicking protein phosphorylation. Panneer Selvam S, De Palma RM, Oaks JJ, Oleinik N, Peterson YK, Stahelin RV, Skordalakes E, Ponnusamy S, Garrett-Mayer E, Smith CD, Ogretmen B. Sci Signal. 2015 Jun 16;8(381):ra58. doi: 10.1126/scisignal.aaa4998. PubMed |
| Pellino-1 positively regulates Toll-like Receptor (TLR) 2 and TLR4 signaling and is suppressed upon induction of endotoxin tolerance. Murphy M, Xiong Y, Pattabiraman G, Qiu F, Medvedev AE. J Biol Chem. 2015 Jun 16. pii: jbc.M115.640128. PubMed |
| The ORF61 protein encoded by Simian Varicella Virus and Varicella Zoster Virus inhibits NFkappaB signaling by interfering with IkappaBalpha degradation. Whitmer T, Malouli D, Uebelhoer LS, DeFilippis VR, Fruh K, Verweij MC. J Virol. 2015 Jun 17. pii: JVI.01149-15. PubMed |
| Induction of functional Brm protein from Brm knockout mice. Thompson KW, Marquez SB, Lu L, Reisman D. Oncoscience. 2015 Apr 18;2(4):349-61. eCollection 2015. PubMed |
| IGF1R/IRS1 signaling confers pathogenic activity on breast tumor cells lacking REST. Meyer K, Albaugh B, Schoenike B, Roopra A. Mol Cell Biol. 2015 Jun 22. pii: MCB.01149-14. PubMed |
| Expression of the multidrug transporter P-glycoprotein is inversely related to that of apoptosis-associated endogenous TRAIL. Souza PS, Madigan JP, Gillet JP, Kapoor K, Ambudkar SV, Maia RC, Gottesman MM, Leung Fung K. Exp Cell Res. 2015 Jun 19. pii: S0014-4827(15)30013-6. doi: 10.1016/j.yexcr.2015.06.005. PubMed |
| mPGES-1 in prostate cancer controls stemness and amplifies EGFR-driven oncogenicity. Finetti F, Terzuoli E, Giachetti A, Santi R, Villari D, Hanaka H, Radmark O, Ziche M, Donnini S. Endocr Relat Cancer. 2015 Jun 25. pii: ERC-15-0277. PubMed |
| Early growth response gene (EGR)-1 regulates leukotriene D4-induced cytokine transcription in Hodgkin lymphoma cells. Han H, Xue-Franzen Y, Miao X, Nagy E, Li N, Xu D, Sjoberg J, Bjorkholm M, Claesson HE. Prostaglandins Other Lipid Mediat. 2015 Jun 23. pii: S1098-8823(15)00075-1. doi: 10.1016/j.prostaglandins.2015.06.004. PubMed |
| DEAD-box RNA helicase DDX23 modulates glioma malignancy via elevating miR-21 biogenesis. Yin J, Park G, Lee JE, Choi EY, Park JY, Kim TH, Park N, Jin X, Jung JE, Shin D, Hong JH, Kim H, Yoo H, Lee SH, Kim YJ, Park JB, Kim JH. Brain. 2015 Sep;138(Pt 9):2553-70. doi: 10.1093/brain/awv167. Epub 2015 Jun 29. PubMed |
| Gene Silencing by RNAi in Mammalian Cells. Ponthan F, Yusoff NM, Soria NM, Heidenreich O, Coffey K. Curr Protoc Mol Biol. 2015 Jul 1;111:26.2.1-26.2.17. doi: 10.1002/0471142727.mb2602s111. PubMed |
| Increased titer and reduced lactate accumulation in recombinant retrovirus production through the down-regulation of HIF1 and PDK. Rodrigues AF, Guerreiro MR, Formas-Oliveira AS, Fernandes P, Blechert AK, Genzel Y, Alves PM, Hu WS, Coroadinha AS. Biotechnol Bioeng. 2015 Jul 1. doi: 10.1002/bit.25691. PubMed |
| ATP binding by NLRP7 is required for inflammasome activation in response to bacterial lipopeptides. Radian AD, Khare S, Chu LH, Dorfleutner A, Stehlik C. Mol Immunol. 2015 Jul 1. pii: S0161-5890(15)00437-X. doi: 10.1016/j.molimm.2015.06.013. PubMed |
| LMAN1 (ERGIC-53) is a potential carrier protein for matrix metalloproteinase-9 glycoprotein secretion. Duellman T, Burnett J, Shin A, Yang J. Biochem Biophys Res Commun. 2015 Jul 3. pii: S0006-291X(15)30222-9. doi: 10.1016/j.bbrc.2015.06.164. PubMed |
| Myogenic induction of adult and pluripotent stem cells using recombinant proteins. Perini I, Elia I, Lo Nigro A, Ronzoni F, Berardi E, Grosemans H, Fukada S, Sampaolesi M. Biochem Biophys Res Commun. 2015 Aug 28;464(3):755-61. doi: 10.1016/j.bbrc.2015.07.022. Epub 2015 Jul 8. PubMed |
| Use of Ferritin Expression, Regulated by Neural Cell-Specific Promoters in Human Adipose Tissue-Derived Mesenchymal Stem Cells, to Monitor Differentiation with Magnetic Resonance Imaging In Vitro. Song C, Wang J, Mo C, Mu S, Jiang X, Li X, Zhong S, Zhao Z, Zhou G. PLoS One. 2015 Jul 15;10(7):e0132480. doi: 10.1371/journal.pone.0132480. eCollection 2015. PubMed |
| Mutant p53-R273H mediates cancer cell survival and anoikis resistance through AKT-dependent suppression of BCL2-modifying factor (BMF). Tan BS, Tiong KH, Choo HL, Chung FF, Hii LW, Tan SH, Yap IK, Pani S, Khor NT, Wong SF, Rosli R, Cheong SK, Leong CO. Cell Death Dis. 2015 Jul 16;6:e1826. doi: 10.1038/cddis.2015.191. PubMed |
| Expression of an estrogen-regulated variant transcript of the peroxisomal branched chain fatty acid oxidase ACOX2 in breast carcinomas. Bjorklund SS, Kristensen VN, Seiler M, Kumar S, Alnaes GI, Ming Y, Kerrigan J, Naume B, Sachidanandam R, Bhanot G, Borresen-Dale AL, Ganesan S. BMC Cancer. 2015 Jul 17;15:524. doi: 10.1186/s12885-015-1510-8. PubMed |
| Dynamic Changes in Cytosolic ATP Levels in Cultured Glutamatergic Neurons During NMDA-Induced Synaptic Activity Supported by Glucose or Lactate. Lange SC, Winkler U, Andresen L, Byhro M, Waagepetersen HS, Hirrlinger J, Bak LK. Neurochem Res. 2015 Dec;40(12):2517-26. doi: 10.1007/s11064-015-1651-9. Epub 2015 Jul 17. PubMed |
| Overexpression of the MRI Reporter Genes Ferritin and Transferrin Receptor Affect Iron Homeostasis and Produce Limited Contrast in Mesenchymal Stem Cells. Pereira SM, Moss D, Williams SR, Murray P, Taylor A. Int J Mol Sci. 2015 Jul 8;16(7):15481-96. doi: 10.3390/ijms160715481. PubMed |
| A Genome-wide CRISPR Screen in Primary Immune Cells to Dissect Regulatory Networks. Parnas O, Jovanovic M, Eisenhaure TM, Herbst RH, Dixit A, Ye CJ, Przybylski D, Platt RJ, Tirosh I, Sanjana NE, Shalem O, Satija R, Raychowdhury R, Mertins P, Carr SA, Zhang F, Hacohen N, Regev A. Cell. 2015 Jul 30;162(3):675-86. doi: 10.1016/j.cell.2015.06.059. Epub 2015 Jul 16. PubMed |
| Spontaneous Cell Competition in Immortalized Mammalian Cell Lines. Penzo-Mendez AI, Chen YJ, Li J, Witze ES, Stanger BZ. PLoS One. 2015 Jul 22;10(7):e0132437. doi: 10.1371/journal.pone.0132437. eCollection 2015. PubMed |
| Polarity Protein Scrib Facilitates Endothelial Inflammatory Signaling. Kruse C, Kurz AR, Palfi K, Humbert PO, Sperandio M, Brandes RP, Fork C, Michaelis UR. Arterioscler Thromb Vasc Biol. 2015 Sep;35(9):1954-62. doi: 10.1161/ATVBAHA.115.305678. Epub 2015 Jul 23. PubMed |
| The homeobox gene DLX4 regulates erythro-megakaryocytic differentiation by stimulating IL-1beta and NF-kappaB signaling. Trinh BQ, Barengo N, Kim SB, Lee JS, Zweidler-McKay PA, Naora H. J Cell Sci. 2015 Aug 15;128(16):3055-67. doi: 10.1242/jcs.168187. Epub 2015 Jul 24. PubMed |
| The role of frataxin in doxorubicin-mediated cardiac hypertrophy. Mouli S, Nanayakkara G, AlAlasmari A, Eldoumani H, Fu X, Berlin A, Lohani M, Nie B, Arnold RD, Kavazis A, Smith F, Beyers R, Denney T, Dhanasekaran M, Zhong J, Quindry J, Amin R. Am J Physiol Heart Circ Physiol. 2015 Sep;309(5):H844-59. doi: 10.1152/ajpheart.00182.2015. Epub 2015 Jul 24. PubMed |
Adhesion to fibronectin regulates Hippo signaling via the FAK-Src-PI3K pathway.
Kim NG, Gumbiner BM.
J Cell Biol. 2015 Aug 3;210(3):503-15. doi: 10.1083/jcb.201501025. Epub 2015 Jul 27.
PubMed
Associated Plasmids |
| alpha-5 Laminin Synthesized by Human Pluripotent Stem Cells Promotes Self-Renewal. Laperle A, Hsiao C, Lampe M, Mortier J, Saha K, Palecek SP, Masters KS. Stem Cell Reports. 2015 Aug 11;5(2):195-206. doi: 10.1016/j.stemcr.2015.06.009. Epub 2015 Jul 30. PubMed |
Genetic determinants of FOXM1 overexpression in epithelial ovarian cancer and functional contribution to cell cycle progression.
Barger CJ, Zhang W, Hillman J, Stablewski AB, Higgins MJ, Vanderhyden BC, Odunsi K, Karpf AR.
Oncotarget. 2015 Jul 16.
PubMed
Associated Plasmids |
| The Mutant KRAS Gene Up-regulates BCL-XL Protein via STAT3 to Confer Apoptosis Resistance That Is Reversed by BIM Protein Induction and BCL-XL Antagonism. Zaanan A, Okamoto K, Kawakami H, Khazaie K, Huang S, Sinicrope FA. J Biol Chem. 2015 Sep 25;290(39):23838-49. doi: 10.1074/jbc.M115.657833. Epub 2015 Aug 5. PubMed |
| Nutlin-3 sensitizes nasopharyngeal carcinoma cells to cisplatin-induced cytotoxicity. Voon YL, Ahmad M, Wong PF, Husaini R, Ng WT, Leong CO, Lane DP, Khoo AS. Oncol Rep. 2015 Oct;34(4):1692-700. doi: 10.3892/or.2015.4177. Epub 2015 Aug 5. PubMed |
| CFTR inactivation by lentiviral vector-mediated RNA interference and CRISPR-Cas9 genome editing in human airway epithelial cells. Bellec J, Bacchetta M, Losa D, Anegon I, Chanson M, Nguyen TH. Curr Gene Ther. 2015;15(5):447-59. PubMed |
| Atypical protein kinase C induces cell transformation by disrupting Hippo/Yap signaling. Archibald A, Al-Masri M, Liew-Spilger A, McCaffrey L. Mol Biol Cell. 2015 Oct 15;26(20):3578-95. doi: 10.1091/mbc.E15-05-0265. Epub 2015 Aug 12. PubMed |
| Mucosally transplanted mesenchymal stem cells stimulate intestinal healing by promoting angiogenesis. Manieri NA, Mack MR, Himmelrich MD, Worthley DL, Hanson EM, Eckmann L, Wang TC, Stappenbeck TS. J Clin Invest. 2015 Sep;125(9):3606-18. doi: 10.1172/JCI81423. Epub 2015 Aug 17. PubMed |
| hVGAT-mCherry: A novel molecular tool for analysis of GABAergic neurons derived from human pluripotent stem cells. DeRosa BA, Belle KC, Thomas BJ, Cukier HN, Pericak-Vance MA, Vance JM, Dykxhoorn DM. Mol Cell Neurosci. 2015 Sep;68:244-57. doi: 10.1016/j.mcn.2015.08.007. Epub 2015 Aug 16. PubMed |
| Antisense-miR-21 enhances differentiation/apoptosis and reduces cancer stemness state on anaplastic thyroid cancer. Haghpanah V, Fallah P, Tavakoli R, Naderi M, Samimi H, Soleimani M, Larijani B. Tumour Biol. 2015 Aug 20. PubMed |
| Quantitative analysis of recombination between YFP and CFP genes of FRET biosensors introduced by lentiviral or retroviral gene transfer. Komatsubara AT, Matsuda M, Aoki K. Sci Rep. 2015 Aug 20;5:13283. doi: 10.1038/srep13283. PubMed |
| Retroviral Transduction of T Cells and T Cell Precursors. Simmons A, Alberola-Ila J. Methods Mol Biol. 2016;1323:99-108. doi: 10.1007/978-1-4939-2809-5_8. PubMed |
| Nuclear Localization of DNAJB6 Is Associated With Survival of Patients With Esophageal Cancer and Reduces AKT Signaling and Proliferation of Cancer Cells. Yu VZ, Wong VC, Dai W, Ko JM, Lam AK, Chan KW, Samant RS, Lung HL, Shuen WH, Law S, Chan YP, Lee NP, Tong DK, Law TT, Lee VH, Lung ML. Gastroenterology. 2015 Dec;149(7):1825-1836.e5. doi: 10.1053/j.gastro.2015.08.025. Epub 2015 Aug 22. PubMed |
| JAM-A regulates cortical dynein localization through Cdc42 to control planar spindle orientation during mitosis. Tuncay H, Brinkmann BF, Steinbacher T, Schurmann A, Gerke V, Iden S, Ebnet K. Nat Commun. 2015 Aug 26;6:8128. doi: 10.1038/ncomms9128. PubMed |
| CD45+ Cells Present Within Mesenchymal Stem Cell Populations Affect Network Formation of Blood-Derived Endothelial Outgrowth Cells. Peters EB, Christoforou N, Moore E, West JL, Truskey GA. Biores Open Access. 2015 Jan 1;4(1):75-88. doi: 10.1089/biores.2014.0029. eCollection 2015. PubMed |
| Pellino-3 promotes endotoxin tolerance and acts as a negative regulator of TLR2 and TLR4 signaling. Murphy MB, Xiong Y, Pattabiraman G, Manavalan TT, Qiu F, Medvedev AE. J Leukoc Biol. 2015 Dec;98(6):963-74. doi: 10.1189/jlb.2VMA0515-229RR. Epub 2015 Aug 26. PubMed |
| Predicting the molecular role of MEIS1 in esophageal squamous cell carcinoma. Rad A, Farshchian M, Forghanifard MM, Matin MM, Bahrami AR, Geerts D, A'rabi A, Memar B, Abbaszadegan MR. Tumour Biol. 2015 Aug 28. PubMed |
| Derivation of LIF-independent mouse iPS cells with modified Oct4. Hirai H, Firpo M, Kikyo N. Stem Cell Res. 2015 Sep;15(2):384-6. doi: 10.1016/j.scr.2015.08.005. Epub 2015 Aug 17. PubMed |
| Mutation of the BRCA1 SQ-cluster results in aberrant mitosis, reduced homologous recombination, and a compensatory increase in non-homologous end joining. Beckta JM, Dever SM, Gnawali N, Khalil A, Sule A, Golding SE, Rosenberg E, Narayanan A, Kehn-Hall K, Xu B, Povirk LF, Valerie K. Oncotarget. 2015 Sep 29;6(29):27674-87. doi: 10.18632/oncotarget.4876. PubMed |
| Asporin Is a Fibroblast-Derived TGF-beta1 Inhibitor and a Tumor Suppressor Associated with Good Prognosis in Breast Cancer. Maris P, Blomme A, Palacios AP, Costanza B, Bellahcene A, Bianchi E, Gofflot S, Drion P, Trombino GE, Di Valentin E, Cusumano PG, Maweja S, Jerusalem G, Delvenne P, Lifrange E, Castronovo V, Turtoi A. PLoS Med. 2015 Sep 1;12(9):e1001871. doi: 10.1371/journal.pmed.1001871. eCollection 2015 Sep. PubMed |
| p53-regulated autophagy is controlled by glycolysis and determines cell fate. Duan L, Perez RE, Davaadelger B, Dedkova EN, Blatter LA, Maki CG. Oncotarget. 2015 Sep 15;6(27):23135-56. PubMed |
Identification of an oncogenic RAB protein.
Wheeler DB, Zoncu R, Root DE, Sabatini DM, Sawyers CL.
Science. 2015 Oct 9;350(6257):211-7. doi: 10.1126/science.aaa4903. Epub 2015 Sep 3.
PubMed
Associated Plasmids |
| Release of Vesicular Stomatitis Virus Spike Protein G-Pseudotyped Lentivirus from the Host Cell Is Impaired upon Low-Density Lipoprotein Receptor Overexpression. Otahal A, Fuchs R, Al-Allaf FA, Blaas D. J Virol. 2015 Nov;89(22):11723-6. doi: 10.1128/JVI.01869-15. Epub 2015 Sep 2. PubMed |
| Use of genetically-encoded calcium indicators for live cell calcium imaging and localization in virus-infected cells. Perry JL, Ramachandran NK, Utama B, Hyser JM. Methods. 2015 Nov 15;90:28-38. doi: 10.1016/j.ymeth.2015.09.004. Epub 2015 Sep 3. PubMed |
| Transcriptome Profiling Reveals Degree of Variability in Induced Pluripotent Stem Cell Lines: Impact for Human Disease Modeling. Schuster J, Halvardson J, Pilar Lorenzo L, Ameur A, Sobol M, Raykova D, Anneren G, Feuk L, Dahl N. Cell Reprogram. 2015 Oct;17(5):327-37. doi: 10.1089/cell.2015.0009. Epub 2015 Sep 8. PubMed |
| The Interferon-induced Transmembrane Proteins, IFITM1, IFITM2, and IFITM3 Inhibit Hepatitis C Virus Entry. Narayana SK, Helbig KJ, McCartney EM, Eyre NS, Bull RA, Eltahla A, Lloyd AR, Beard MR. J Biol Chem. 2015 Oct 23;290(43):25946-59. doi: 10.1074/jbc.M115.657346. Epub 2015 Sep 9. PubMed |
| CRISPR/Cas9 System as an Agent for Eliminating Polyomavirus JC Infection. Wollebo HS, Bellizzi A, Kaminski R, Hu W, White MK, Khalili K. PLoS One. 2015 Sep 11;10(9):e0136046. doi: 10.1371/journal.pone.0136046. eCollection 2015. PubMed |
| Structural centrosome aberrations favor proliferation by abrogating microtubule-dependent tissue integrity of breast epithelial mammospheres. Schnerch D, Nigg EA. Oncogene. 2015 Sep 14. doi: 10.1038/onc.2015.332. PubMed |
| The TRAF-interacting protein (TRAIP) is a novel E2F target with peak expression in mitosis. Chapard C, Hohl D, Huber M. Oncotarget. 2015 Aug 28;6(25):20933-45. PubMed |
| Global Transcriptome Analysis Reveals That Poly(ADP-Ribose) Polymerase 1 Regulates Gene Expression through EZH2. Martin KA, Cesaroni M, Denny MF, Lupey LN, Tempera I. Mol Cell Biol. 2015 Dec;35(23):3934-44. doi: 10.1128/MCB.00635-15. Epub 2015 Sep 14. PubMed |
MicroRNA-based conversion of human fibroblasts into striatal medium spiny neurons.
Richner M, Victor MB, Liu Y, Abernathy D, Yoo AS.
Nat Protoc. 2015 Oct;10(10):1543-55. doi: 10.1038/nprot.2015.102. Epub 2015 Sep 17.
PubMed
Associated Plasmids |
| Basal cells of the human airways acquire mesenchymal traits in idiopathic pulmonary fibrosis and in culture. Jonsdottir HR, Arason AJ, Palsson R, Franzdottir SR, Gudbjartsson T, Isaksson HJ, Gudmundsson G, Gudjonsson T, Magnusson MK. Lab Invest. 2015 Dec;95(12):1418-28. doi: 10.1038/labinvest.2015.114. Epub 2015 Sep 21. PubMed |
| Routes of Ca2+ Shuttling during Ca2+ Oscillations: FOCUS ON THE ROLE OF MITOCHONDRIAL Ca2+ HANDLING AND CYTOSOLIC Ca2+ BUFFERS. Pecze L, Blum W, Schwaller B. J Biol Chem. 2015 Nov 20;290(47):28214-30. doi: 10.1074/jbc.M115.663179. Epub 2015 Sep 22. PubMed |
| OTX2 is a therapeutic target for retinoblastoma and may function as a common factor between C-MYC, CRX, and phosphorylated RB pathways. Li J, Di C, Jing J, Di Q, Nakhla J, Adamson DC. Int J Oncol. 2015 Nov;47(5):1703-10. doi: 10.3892/ijo.2015.3179. Epub 2015 Sep 23. PubMed |
Direct Induction of Trophoblast Stem Cells from Murine Fibroblasts.
Kubaczka C, Senner CE, Cierlitza M, Arauzo-Bravo MJ, Kuckenberg P, Peitz M, Hemberger M, Schorle H.
Cell Stem Cell. 2015 Sep 22. pii: S1934-5909(15)00360-4. doi: 10.1016/j.stem.2015.08.005.
PubMed
Associated Plasmids |
| LKB1 loss promotes endometrial cancer progression via CCL2-dependent macrophage recruitment. Pena CG, Nakada Y, Saatcioglu HD, Aloisio GM, Cuevas I, Zhang S, Miller DS, Lea JS, Wong KK, DeBerardinis RJ, Amelio AL, Brekken RA, Castrillon DH. J Clin Invest. 2015 Nov 2;125(11):4063-76. doi: 10.1172/JCI82152. Epub 2015 Sep 28. PubMed |
| EMMPRIN regulates tumor growth and metastasis by recruiting bone marrow-derived cells through paracrine signaling of SDF-1 and VEGF. Chen Y, Gou X, Kong DK, Wang X, Wang J, Chen Z, Huang C, Zhou J. Oncotarget. 2015 Oct 20;6(32):32575-85. doi: 10.18632/oncotarget.5331. PubMed |
| ZIC2-dependent OCT4 activation drives self-renewal of human liver cancer stem cells. Zhu P, Wang Y, He L, Huang G, Du Y, Zhang G, Yan X, Xia P, Ye B, Wang S, Hao L, Wu J, Fan Z. J Clin Invest. 2015 Oct 1;125(10):3795-808. doi: 10.1172/JCI81979. Epub 2015 Aug 31. PubMed |
| Differentiation-Dependent KLF4 Expression Promotes Lytic Epstein-Barr Virus Infection in Epithelial Cells. Nawandar DM, Wang A, Makielski K, Lee D, Ma S, Barlow E, Reusch J, Jiang R, Wille CK, Greenspan D, Greenspan JS, Mertz JE, Hutt-Fletcher L, Johannsen EC, Lambert PF, Kenney SC. PLoS Pathog. 2015 Oct 2;11(10):e1005195. doi: 10.1371/journal.ppat.1005195. eCollection 2015 Oct. PubMed |
| Succination is Increased on Select Proteins in the Brainstem of the NADH dehydrogenase (ubiquinone) Fe-S protein 4 (Ndufs4) Knockout Mouse, a Model of Leigh Syndrome. Piroli GG, Manuel AM, Clapper AC, Walla MD, Baatz JE, Palmiter RD, Quintana A, Frizzell N. Mol Cell Proteomics. 2016 Feb;15(2):445-61. doi: 10.1074/mcp.M115.051516. Epub 2015 Oct 8. PubMed |
| MFG-E8 Is Critical for Embryonic Stem Cell-Mediated T Cell Immunomodulation. Tan Y, AlKhamees B, Jia D, Li L, Couture JF, Figeys D, Jinushi M, Wang L. Stem Cell Reports. 2015 Nov 10;5(5):741-52. doi: 10.1016/j.stemcr.2015.09.005. Epub 2015 Oct 8. PubMed |
| Transcriptional repression by the HDAC4-RelB-p52 complex regulates multiple myeloma survival and growth. Vallabhapurapu SD, Noothi SK, Pullum DA, Lawrie CH, Pallapati R, Potluri V, Kuntzen C, Khan S, Plas DR, Orlowski RZ, Chesi M, Kuehl WM, Bergsagel PL, Karin M, Vallabhapurapu S. Nat Commun. 2015 Oct 12;6:8428. doi: 10.1038/ncomms9428. PubMed |
| Reliable and inexpensive expression of large, tagged, exogenous proteins in murine bone marrow-derived macrophages using a second generation lentiviral system. Miller MR, Blystone SD. J Biol Methods. 2015;2(3):e23. PubMed |
| MCL-1-independent mechanisms of synergy between dual PI3K/mTOR and BCL-2 inhibition in diffuse large B cell lymphoma. Lee JS, Tang SS, Ortiz V, Vo TT, Fruman DA. Oncotarget. 2015 Nov 3;6(34):35202-17. doi: 10.18632/oncotarget.6051. PubMed |
| Targeting of BCL2 Family Proteins with ABT-199 and Homoharringtonine Reveals BCL2- and MCL1-Dependent Subgroups of Diffuse Large B-Cell Lymphoma. Klanova M, Andera L, Brazina J, Svadlenka J, Benesova S, Soukup J, Prukova D, Vejmelkova D, Jaksa R, Helman K, Vockova P, Lateckova L, Molinsky J, Maswabi BC, Alam M, Kodet R, Pytlik R, Trneny M, Klener P. Clin Cancer Res. 2015 Oct 14. PubMed |
| The Effector Domain of MARCKS Is a Nuclear Localization Signal that Regulates Cellular PIP2 Levels and Nuclear PIP2 Localization. Rohrbach TD, Shah N, Jackson WP, Feeney EV, Scanlon S, Gish R, Khodadadi R, Hyde SO, Hicks PH, Anderson JC, Jarboe JS, Willey CD. PLoS One. 2015 Oct 15;10(10):e0140870. doi: 10.1371/journal.pone.0140870. eCollection 2015. PubMed |
| Knockdown of GLP-1 Receptors in Vagal Afferents Affects Normal Food Intake and Glycemia. Krieger JP, Arnold M, Pettersen KG, Lossel P, Langhans W, Lee SJ. Diabetes. 2016 Jan;65(1):34-43. doi: 10.2337/db15-0973. Epub 2015 Oct 15. PubMed |
| Targeting mitochondrial RNA polymerase in acute myeloid leukemia. Bralha FN, Liyanage SU, Hurren R, Wang X, Son MH, Fung TA, Chingcuanco FB, Tung AY, Andreazza AC, Psarianos P, Schimmer AD, Salmena L, Laposa RR. Oncotarget. 2015 Nov 10;6(35):37216-28. doi: 10.18632/oncotarget.6129. PubMed |
| Interferon Kappa Inhibits Human Papillomavirus 31 Transcription by Inducing Sp100 Proteins. Habiger C, Jager G, Walter M, Iftner T, Stubenrauch F. J Virol. 2015 Oct 21;90(2):694-704. doi: 10.1128/JVI.02137-15. PubMed |
DECKO: Single-oligo, dual-CRISPR deletion of genomic elements including long non-coding RNAs.
Aparicio-Prat E, Arnan C, Sala I, Bosch N, Guigo R, Johnson R.
BMC Genomics. 2015 Oct 23;16(1):846. doi: 10.1186/s12864-015-2086-z.
PubMed
Associated Plasmids |
Highly specific epigenome editing by CRISPR-Cas9 repressors for silencing of distal regulatory elements.
Thakore PI, D'Ippolito AM, Song L, Safi A, Shivakumar NK, Kabadi AM, Reddy TE, Crawford GE, Gersbach CA.
Nat Methods. 2015 Dec;12(12):1143-9. doi: 10.1038/nmeth.3630. Epub 2015 Oct 26.
PubMed
Associated Plasmids |
| Skeletal Muscle Phospholipid Metabolism Regulates Insulin Sensitivity and Contractile Function. Funai K, Lodhi IJ, Spears LD, Yin L, Song H, Klein S, Semenkovich CF. Diabetes. 2016 Feb;65(2):358-70. doi: 10.2337/db15-0659. Epub 2015 Oct 28. PubMed |
| Identification of short-form RON as a novel intrinsic resistance mechanism for anti-MET therapy in MET-positive gastric cancer. Wu Z, Zhang Z, Ge X, Lin Y, Dai C, Chang J, Liu X, Geng R, Wang C, Chen H, Sun M, Guo W, Li J. Oncotarget. 2015 Dec 1;6(38):40519-34. doi: 10.18632/oncotarget.5816. PubMed |
| Combinatorial BTK and MALT1 inhibition augments killing of CD79 mutant diffuse large B cell lymphoma. Nagel D, Bognar M, Eitelhuber AC, Kutzner K, Vincendeau M, Krappmann D. Oncotarget. 2015 Dec 8;6(39):42232-42. doi: 10.18632/oncotarget.6273. PubMed |
| The leukodystrophy protein FAM126A (hyccin) regulates PtdIns(4)P synthesis at the plasma membrane. Baskin JM, Wu X, Christiano R, Oh MS, Schauder CM, Gazzerro E, Messa M, Baldassari S, Assereto S, Biancheri R, Zara F, Minetti C, Raimondi A, Simons M, Walther TC, Reinisch KM, De Camilli P. Nat Cell Biol. 2016 Jan;18(1):132-8. doi: 10.1038/ncb3271. Epub 2015 Nov 16. PubMed |
| Fat4 suppression induces Yap translocation accounting for the promoted proliferation and migration of gastric cancer cells. Ma L, Cui J, Xi H, Bian S, Wei B, Chen L. Cancer Biol Ther. 2016;17(1):36-47. doi: 10.1080/15384047.2015.1108488. PubMed |
| ETS family transcriptional regulators drive chromatin dynamics and malignancy in squamous cell carcinomas. Yang H, Schramek D, Adam RC, Keyes BE, Wang P, Zheng D, Fuchs E. Elife. 2015 Nov 21;4. pii: e10870. doi: 10.7554/eLife.10870. PubMed |
| Targeting p300 Addiction in CBP-Deficient Cancers Causes Synthetic Lethality by Apoptotic Cell Death due to Abrogation of MYC Expression. Ogiwara H, Sasaki M, Mitachi T, Oike T, Higuchi S, Tominaga Y, Kohno T. Cancer Discov. 2016 Apr;6(4):430-45. doi: 10.1158/2159-8290.CD-15-0754. Epub 2015 Nov 24. PubMed |
| A PCR-Based Method to Construct Lentiviral Vector Expressing Double Tough Decoy for miRNA Inhibition. Qiu H, Zhong J, Luo L, Liu N, Kang K, Qu J, Peng W, Gou D. PLoS One. 2015 Dec 1;10(12):e0143864. doi: 10.1371/journal.pone.0143864. eCollection 2015. PubMed |
| PTEN deficiency reprogrammes human neural stem cells towards a glioblastoma stem cell-like phenotype. Duan S, Yuan G, Liu X, Ren R, Li J, Zhang W, Wu J, Xu X, Fu L, Li Y, Yang J, Zhang W, Bai R, Yi F, Suzuki K, Gao H, Esteban CR, Zhang C, Izpisua Belmonte JC, Chen Z, Wang X, Jiang T, Qu J, Tang F, Liu GH. Nat Commun. 2015 Dec 3;6:10068. doi: 10.1038/ncomms10068. PubMed |
| alpha-synuclein interacts with SOD1 and promotes its oligomerization. Helferich AM, Ruf WP, Grozdanov V, Freischmidt A, Feiler MS, Zondler L, Ludolph AC, McLean PJ, Weishaupt JH, Danzer KM. Mol Neurodegener. 2015 Dec 8;10:66. doi: 10.1186/s13024-015-0062-3. PubMed |
| The Notch and Wnt pathways regulate stemness and differentiation in human fallopian tube organoids. Kessler M, Hoffmann K, Brinkmann V, Thieck O, Jackisch S, Toelle B, Berger H, Mollenkopf HJ, Mangler M, Sehouli J, Fotopoulou C, Meyer TF. Nat Commun. 2015 Dec 8;6:8989. doi: 10.1038/ncomms9989. PubMed |
| Deregulated KLF4 Expression in Myeloid Leukemias Alters Cell Proliferation and Differentiation through MicroRNA and Gene Targets. Morris VA, Cummings CL, Korb B, Boaglio S, Oehler VG. Mol Cell Biol. 2015 Dec 7;36(4):559-73. doi: 10.1128/MCB.00712-15. PubMed |
| A Common CCK-B Receptor Intronic Variant in Pancreatic Adenocarcinoma in a Hungarian Cohort. Balazs A, Nemeth BC, Ordog B, Hegyi E, Hritz I, Czako L, Czimmer J, Godi S, Csiszko A, Rakonczay Z Jr, Parniczky A, Izbeki F, Halasz A, Kahan Z, Hegyi P, Sahin-Toth M. Pancreas. 2016 Apr;45(4):541-5. doi: 10.1097/MPA.0000000000000539. PubMed |
| Characterization of a Novel Human-Specific STING Agonist that Elicits Antiviral Activity Against Emerging Alphaviruses. Sali TM, Pryke KM, Abraham J, Liu A, Archer I, Broeckel R, Staverosky JA, Smith JL, Al-Shammari A, Amsler L, Sheridan K, Nilsen A, Streblow DN, DeFilippis VR. PLoS Pathog. 2015 Dec 8;11(12):e1005324. doi: 10.1371/journal.ppat.1005324. eCollection 2015 Dec. PubMed |
| A new design of a lentiviral shRNA vector with inducible co-expression of ARGONAUTE 2 for enhancing gene silencing efficiency. He J, Huang L, Qiu H, Li J, Luo L, Li Y, Tian S, Kang K, Luo J, Liu L, Gou D. Cell Biosci. 2015 Dec 8;5:67. doi: 10.1186/s13578-015-0058-2. eCollection 2015. PubMed |
| A Gene Expression Signature Associated with Overall Survival in Patients with Hepatocellular Carcinoma Suggests a New Treatment Strategy. Gillet JP, Andersen JB, Madigan JP, Varma S, Bagni RK, Powell K, Burgan WE, Wu CP, Calcagno AM, Ambudkar SV, Thorgeirsson SS, Gottesman MM. Mol Pharmacol. 2016 Feb;89(2):263-72. doi: 10.1124/mol.115.101360. Epub 2015 Dec 14. PubMed |
| TBX3 Knockdown Decreases Reprogramming Efficiency of Human Cells. Klingenstein M, Raab S, Achberger K, Kleger A, Liebau S, Linta L. Stem Cells Int. 2016;2016:6759343. doi: 10.1155/2016/6759343. Epub 2015 Nov 30. PubMed |
| Upregulation of EMMPRIN (OX47) in Rat Dorsal Root Ganglion Contributes to the Development of Mechanical Allodynia after Nerve Injury. Wang Q, Sun Y, Ren Y, Gao Y, Tian L, Liu Y, Pu Y, Gou X, Chen Y, Lu Y. Neural Plast. 2015;2015:249756. doi: 10.1155/2015/249756. Epub 2015 Nov 30. PubMed |
| Manipulation of the N-terminal sequence of the Borna disease virus X protein improves its mitochondrial targeting and neuroprotective potential. Ferre CA, Davezac N, Thouard A, Peyrin JM, Belenguer P, Miquel MC, Gonzalez-Dunia D, Szelechowski M. FASEB J. 2015 Dec 23. pii: fj.15-279620. PubMed |
| Ebola virus mediated infectivity is restricted in canine and feline cells. Han Z, Bart SM, Ruthel G, Vande Burgt NH, Haines KM, Volk SW, Vite CH, Freedman BD, Bates P, Harty RN. Vet Microbiol. 2016 Jan 15;182:102-7. doi: 10.1016/j.vetmic.2015.11.011. Epub 2015 Nov 17. PubMed |
| Genome-Wide Transcriptional Regulation Mediated by Biochemically Distinct SWI/SNF Complexes. Raab JR, Resnick S, Magnuson T. PLoS Genet. 2015 Dec 30;11(12):e1005748. doi: 10.1371/journal.pgen.1005748. eCollection 2015 Dec. PubMed |
| NIPBL Controls RNA Biogenesis to Prevent Activation of the Stress Kinase PKR. Yuen KC, Xu B, Krantz ID, Gerton JL. Cell Rep. 2016 Jan 5;14(1):93-102. doi: 10.1016/j.celrep.2015.12.012. Epub 2015 Dec 24. PubMed |
| The Polymerase Activity of Mammalian DNA Pol zeta Is Specifically Required for Cell and Embryonic Viability. Lange SS, Tomida J, Boulware KS, Bhetawal S, Wood RD. PLoS Genet. 2016 Jan 4;12(1):e1005759. doi: 10.1371/journal.pgen.1005759. eCollection 2016 Jan. PubMed |
| Inhibition of Canonical NF-kappaB Signaling by a Small Molecule Targeting NEMO-Ubiquitin Interaction. Vincendeau M, Hadian K, Messias AC, Brenke JK, Halander J, Griesbach R, Greczmiel U, Bertossi A, Stehle R, Nagel D, Demski K, Velvarska H, Niessing D, Geerlof A, Sattler M, Krappmann D. Sci Rep. 2016 Jan 7;6:18934. doi: 10.1038/srep18934. PubMed |
| Research Resource: Genetic Labeling of Human Islet Alpha Cells. Pauerstein PT, Park KM, Peiris HS, Wang J, Kim SK. Mol Endocrinol. 2016 Feb;30(2):248-53. doi: 10.1210/me.2015-1220. Epub 2016 Jan 8. PubMed |
| Haploinsufficiency of BAZ1B contributes to Williams syndrome through transcriptional dysregulation of neurodevelopmental pathways. Lalli MA, Jang J, Park JC, Wang Y, Guzman E, Zhou H, Audouard M, Bridges D, Tovar KR, Papuc SM, Tutulan-Cunita AC, Huang Y, Budisteanu M, Arghir A, Kosik KS. Hum Mol Genet. 2016 Jan 10. pii: ddw010. PubMed |
| Epithelial-to-Mesenchymal Transition of RPE Cells In Vitro Confers Increased beta1,6-N-Glycosylation and Increased Susceptibility to Galectin-3 Binding. Priglinger CS, Obermann J, Szober CM, Merl-Pham J, Ohmayer U, Behler J, Gruhn F, Kreutzer TC, Wertheimer C, Geerlof A, Priglinger SG, Hauck SM. PLoS One. 2016 Jan 13;11(1):e0146887. doi: 10.1371/journal.pone.0146887. eCollection 2016. PubMed |
| Selection-free gene repair after adenoviral vector transduction of designer nucleases: rescue of dystrophin synthesis in DMD muscle cell populations. Maggio I, Stefanucci L, Janssen JM, Liu J, Chen X, Mouly V, Goncalves MA. Nucleic Acids Res. 2016 Jan 13. pii: gkv1540. PubMed |
| Disease causing mutations in inverted formin 2 regulate its binding to G-actin, F-actin capping protein (CapZ alpha-1) and profilin 2. Rollason R, Wherlock M, Heath JA, Heesom KJ, Saleem MA, Welsh GI. Biosci Rep. 2016 Jan 13;36(1):e00302. doi: 10.1042/BSR20150252. PubMed |
| Human pluripotent stem cell culture density modulates YAP signaling. Hsiao C, Lampe M, Nillasithanukroh S, Han W, Lian X, Palecek SP. Biotechnol J. 2016 Jan 14. doi: 10.1002/biot.201500374. PubMed |
| Oncogenic CARMA1 couples NF-kappaB and beta-catenin signaling in diffuse large B-cell lymphomas. Bognar MK, Vincendeau M, Erdmann T, Seeholzer T, Grau M, Linnemann JR, Ruland J, Scheel CH, Lenz P, Ott G, Lenz G, Hauck SM, Krappmann D. Oncogene. 2016 Jan 18. doi: 10.1038/onc.2015.493. PubMed |
| Live imaging of microtubule dynamics in organotypic hippocampal slice cultures. Schatzle P, Kapitein LC, Hoogenraad CC. Methods Cell Biol. 2016;131:107-26. doi: 10.1016/bs.mcb.2015.06.006. Epub 2015 Sep 3. PubMed |
| Induced Pluripotent Stem Cells of Microtus levis x Microtus arvalis Vole Hybrids: Conditions Necessary for Their Generation and Self-Renewal. Grigor'eva EV, Shevchenko AI, Medvedev SP, Mazurok NA, Zhelezova AI, Zakian SM. Acta Naturae. 2015 Oct-Dec;7(4):56-69. PubMed |
| TFEB and TFE3 are novel components of the integrated stress response. Martina JA, Diab HI, Brady OA, Puertollano R. EMBO J. 2016 Mar 1;35(5):479-95. doi: 10.15252/embj.201593428. Epub 2016 Jan 25. PubMed |
| Mitochondrial genome variations and functional characterization in Han Chinese families with schizophrenia. Bi R, Tang J, Zhang W, Li X, Chen SY, Yu D, Chen X, Yao YG. Schizophr Res. 2016 Jan 25. pii: S0920-9964(16)30011-1. doi: 10.1016/j.schres.2016.01.011. PubMed |
| Staufen1 Regulates Multiple Alternative Splicing Events either Positively or Negatively in DM1 Indicating Its Role as a Disease Modifier. Bondy-Chorney E, Crawford Parks TE, Ravel-Chapuis A, Klinck R, Rocheleau L, Pelchat M, Chabot B, Jasmin BJ, Cote J. PLoS Genet. 2016 Jan 29;12(1):e1005827. doi: 10.1371/journal.pgen.1005827. eCollection 2016 Jan. PubMed |
| Agonist-induced activation of histamine H3 receptor signals to extracellular signal-regulated kinases 1 and 2 through PKC-, PLD-, and EGFR-dependent mechanisms. Lai X, Ye L, Liao Y, Jin L, Ma Q, Lu B, Sun Y, Shi Y, Zhou N. J Neurochem. 2016 Apr;137(2):200-15. doi: 10.1111/jnc.13559. Epub 2016 Mar 10. PubMed |
| Opposing Roles of JNK and p38 in Lymphangiogenesis in Melanoma. Puujalka E, Heinz M, Hoesel B, Friedl P, Schweighofer B, Wenzina J, Pirker C, Schmid JA, Loewe R, Wagner EF, Berger W, Petzelbauer P. J Invest Dermatol. 2016 May;136(5):967-77. doi: 10.1016/j.jid.2016.01.020. Epub 2016 Jan 30. PubMed |
| WNT/beta-catenin signaling mediates human neural crest induction via a pre-neural border intermediate. Leung AW, Murdoch B, Salem AF, Prasad MS, Gomez GA, Garcia-Castro MI. Development. 2016 Feb 1;143(3):398-410. doi: 10.1242/dev.130849. PubMed |
| Regulation of Nuclear Receptor Nur77 by miR-124. Tenga A, Beard JA, Takwi A, Wang YM, Chen T. PLoS One. 2016 Feb 3;11(2):e0148433. doi: 10.1371/journal.pone.0148433. eCollection 2016. PubMed |
| MeCP2 SUMOylation rescues Mecp2-mutant-induced behavioural deficits in a mouse model of Rett syndrome. Tai DJ, Liu YC, Hsu WL, Ma YL, Cheng SJ, Liu SY, Lee EH. Nat Commun. 2016 Feb 4;7:10552. doi: 10.1038/ncomms10552. PubMed |
| Microtubules Inhibit E-Cadherin Adhesive Activity by Maintaining Phosphorylated p120-Catenin in a Colon Carcinoma Cell Model. Maiden SL, Petrova YI, Gumbiner BM. PLoS One. 2016 Feb 4;11(2):e0148574. doi: 10.1371/journal.pone.0148574. eCollection 2016. PubMed |
| HDAC7 inhibition resets STAT3 tumorigenic activity in human glioblastoma independently of EGFR and PTEN: new opportunities for selected targeted therapies. Peixoto P, Blomme A, Costanza B, Ronca R, Rezzola S, Palacios AP, Schoysman L, Boutry S, Goffart N, Peulen O, Maris P, Di Valentin E, Hennequiere V, Bianchi E, Henry A, Meunier P, Rogister B, Muller RN, Delvenne P, Bellahcene A, Castronovo V, Turtoi A. Oncogene. 2016 Aug 25;35(34):4481-94. doi: 10.1038/onc.2015.506. Epub 2016 Feb 8. PubMed |
| Lysophosphatidic acid activates Arf6 to promote the mesenchymal malignancy of renal cancer. Hashimoto S, Mikami S, Sugino H, Yoshikawa A, Hashimoto A, Onodera Y, Furukawa S, Handa H, Oikawa T, Okada Y, Oya M, Sabe H. Nat Commun. 2016 Feb 8;7:10656. doi: 10.1038/ncomms10656. PubMed |
| Feedback activation of neurofibromin terminates growth factor-induced Ras activation. Hennig A, Markwart R, Wolff K, Schubert K, Cui Y, Prior IA, Esparza-Franco MA, Ladds G, Rubio I. Cell Commun Signal. 2016 Feb 9;14:5. doi: 10.1186/s12964-016-0128-z. PubMed |
| The Endoplasmic Reticulum Chaperone Calnexin Is a NADPH Oxidase NOX4 Interacting Protein. Prior KK, Wittig I, Leisegang MS, Groenendyk J, Weissmann N, Michalak M, Jansen-Durr P, Shah AM, Brandes RP. J Biol Chem. 2016 Mar 25;291(13):7045-59. doi: 10.1074/jbc.M115.710772. Epub 2016 Feb 9. PubMed |
| The Sigma-2 Receptor and Progesterone Receptor Membrane Component 1 are Different Binding Sites Derived From Independent Genes. Chu UB, Mavlyutov TA, Chu ML, Yang H, Schulman A, Mesangeau C, McCurdy CR, Guo LW, Ruoho AE. EBioMedicine. 2015 Oct 19;2(11):1806-13. doi: 10.1016/j.ebiom.2015.10.017. eCollection 2015 Nov. PubMed |
| GemC1 controls multiciliogenesis in the airway epithelium. Arbi M, Pefani DE, Kyrousi C, Lalioti ME, Kalogeropoulou A, Papanastasiou AD, Taraviras S, Lygerou Z. EMBO Rep. 2016 Mar;17(3):400-13. doi: 10.15252/embr.201540882. Epub 2016 Feb 4. PubMed |
| Progesterone receptor (PR) polyproline domain (PPD) mediates inhibition of epidermal growth factor receptor (EGFR) signaling in non-small cell lung cancer cells. Kawprasertsri S, Pietras RJ, Marquez-Garban DC, Boonyaratanakornkit V. Cancer Lett. 2016 May 1;374(2):279-91. doi: 10.1016/j.canlet.2016.02.014. Epub 2016 Feb 15. PubMed |
| Specifically modified Env immunogens activate B-cell precursors of broadly neutralizing HIV-1 antibodies in transgenic mice. McGuire AT, Gray MD, Dosenovic P, Gitlin AD, Freund NT, Petersen J, Correnti C, Johnsen W, Kegel R, Stuart AB, Glenn J, Seaman MS, Schief WR, Strong RK, Nussenzweig MC, Stamatatos L. Nat Commun. 2016 Feb 24;7:10618. doi: 10.1038/ncomms10618. PubMed |
| Defining functional classes of Barth syndrome mutation in humans. Lu YW, Galbraith L, Herndon JD, Lu YL, Pras-Raves M, Vervaart M, Van Kampen A, Luyf A, Koehler CM, McCaffery JM, Gottlieb E, Vaz FM, Claypool SM. Hum Mol Genet. 2016 May 1;25(9):1754-70. doi: 10.1093/hmg/ddw046. Epub 2016 Feb 16. PubMed |
| GATA3-dependent cellular reprogramming requires activation-domain dependent recruitment of a chromatin remodeler. Takaku M, Grimm SA, Shimbo T, Perera L, Menafra R, Stunnenberg HG, Archer TK, Machida S, Kurumizaka H, Wade PA. Genome Biol. 2016 Feb 27;17:36. doi: 10.1186/s13059-016-0897-0. PubMed |
| The retrovirus HTLV-1 inserts an ectopic CTCF-binding site into the human genome. Satou Y, Miyazato P, Ishihara K, Yaguchi H, Melamed A, Miura M, Fukuda A, Nosaka K, Watanabe T, Rowan AG, Nakao M, Bangham CR. Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):3054-9. doi: 10.1073/pnas.1423199113. Epub 2016 Feb 29. PubMed |
| Radiosensitization by PARP Inhibition in DNA Repair Proficient and Deficient Tumor Cells: Proliferative Recovery in Senescent Cells. Alotaibi M, Sharma K, Saleh T, Povirk LF, Hendrickson EA, Gewirtz DA. Radiat Res. 2016 Mar;185(3):229-45. doi: 10.1667/RR14202.1. Epub 2016 Mar 2. PubMed |
| LKB1 inhibits the proliferation of gastric cancer cells by suppressing the nuclear translocation of Yap and beta-catenin. Ma LG, Bian SB, Cui JX, Xi HQ, Zhang KC, Qin HZ, Zhu XM, Chen L. Int J Mol Med. 2016 Apr;37(4):1039-48. doi: 10.3892/ijmm.2016.2494. Epub 2016 Feb 19. PubMed |
| An integrin beta4-EGFR unit promotes hepatocellular carcinoma lung metastases by enhancing anchorage independence through activation of FAK-AKT pathway. Leng C, Zhang ZG, Chen WX, Luo HP, Song J, Dong W, Zhu XR, Chen XP, Liang HF, Zhang BX. Cancer Lett. 2016 Jun 28;376(1):188-96. doi: 10.1016/j.canlet.2016.03.023. Epub 2016 Mar 17. PubMed |
| Ultrahigh-throughput Generation and Characterization of Cellular Aggregates in Laser-ablated Microwells of Poly(dimethylsiloxane). Albritton JL, Roybal JD, Paulsen SJ, Calafat N, Flores-Zaher JA, Farach-Carson MC, Gibbons DL, Miller JS. RSC Adv. 2016 Jan 1;6(11):8980-8991. Epub 2016 Jan 12. PubMed |
| Enhancing DPYSL3 gene expression via a promoter-targeted small activating RNA approach suppresses cancer cell motility and metastasis. Li C, Jiang W, Hu Q, Li LC, Dong L, Chen R, Zhang Y, Tang Y, Thrasher JB, Liu CB, Li B. Oncotarget. 2016 Mar 23. doi: 10.18632/oncotarget.8290. PubMed |
| PCGF2 negatively regulates arsenic trioxide-induced PML-RARA protein degradation via UBE2I inhibition in NB4 cells. Jo S, Lee YL, Kim S, Lee H, Chung H. Biochim Biophys Acta. 2016 Jul;1863(7 Pt A):1499-509. doi: 10.1016/j.bbamcr.2016.03.019. Epub 2016 Mar 24. PubMed |
| P53- and mevalonate pathway-driven malignancies require Arf6 for metastasis and drug resistance. Hashimoto A, Oikawa T, Hashimoto S, Sugino H, Yoshikawa A, Otsuka Y, Handa H, Onodera Y, Nam JM, Oneyama C, Okada M, Fukuda M, Sabe H. J Cell Biol. 2016 Apr 11;213(1):81-95. doi: 10.1083/jcb.201510002. Epub 2016 Apr 4. PubMed |
| Complex Regulation Pattern of IRF3 Activation Revealed by a Novel Dimerization Reporter System. Wang Z, Ji J, Peng D, Ma F, Cheng G, Qin FX. J Immunol. 2016 May 15;196(10):4322-30. doi: 10.4049/jimmunol.1502458. Epub 2016 Apr 4. PubMed |
| Circadian factors BMAL1 and RORalpha control HIF-1alpha transcriptional activity in nucleus pulposus cells: implications in maintenance of intervertebral disc health. Suyama K, Silagi ES, Choi H, Sakabe K, Mochida J, Shapiro IM, Risbud MV. Oncotarget. 2016 Mar 31. doi: 10.18632/oncotarget.8521. PubMed |
| Large-scale production of megakaryocytes from human pluripotent stem cells by chemically defined forward programming. Moreau T, Evans AL, Vasquez L, Tijssen MR, Yan Y, Trotter MW, Howard D, Colzani M, Arumugam M, Wu WH, Dalby A, Lampela R, Bouet G, Hobbs CM, Pask DC, Payne H, Ponomaryov T, Brill A, Soranzo N, Ouwehand WH, Pedersen RA, Ghevaert C. Nat Commun. 2016 Apr 7;7:11208. doi: 10.1038/ncomms11208. PubMed |
| Infection of epithelial cells with Chlamydia trachomatis inhibits TNF-induced apoptosis at the level of receptor internalisation while leaving non-apoptotic TNF-signalling intact. Kontchou CW, Tzivelekidis T, Gentle IE, Hacker G. Cell Microbiol. 2016 Apr 8. doi: 10.1111/cmi.12598. PubMed |
| Thyroid follicle development requires Smad1/5- and endothelial cell-dependent basement membrane assembly. Villacorte M, Delmarcelle AS, Lernoux M, Bouquet M, Lemoine P, Bolsee J, Umans L, de Sousa Lopes SC, Van Der Smissen P, Sasaki T, Bommer G, Henriet P, Refetoff S, Lemaigre FP, Zwijsen A, Courtoy PJ, Pierreux CE. Development. 2016 Jun 1;143(11):1958-70. doi: 10.1242/dev.134171. Epub 2016 Apr 11. PubMed |
| ExtraPEG: A Polyethylene Glycol-Based Method for Enrichment of Extracellular Vesicles. Rider MA, Hurwitz SN, Meckes DG Jr. Sci Rep. 2016 Apr 12;6:23978. doi: 10.1038/srep23978. PubMed |
| Activation of PTHrP-cAMP-CREB1 signaling following p53 loss is essential for osteosarcoma initiation and maintenance. Walia MK, Ho PM, Taylor S, Ng AJ, Gupte A, Chalk AM, Zannettino AC, Martin TJ, Walkley CR. Elife. 2016 Apr 12;5. pii: e13446. doi: 10.7554/eLife.13446. PubMed |
| The Herpes Simplex Virus Virion Host Shutoff Protein Enhances Translation of Viral True Late mRNAs Independently of Suppressing Protein Kinase R and Stress Granule Formation. Dauber B, Poon D, Dos Santos T, Duguay BA, Mehta N, Saffran HA, Smiley JR. J Virol. 2016 Jun 10;90(13):6049-57. doi: 10.1128/JVI.03180-15. Print 2016 Jul 1. PubMed |
| Enhanced direct conversion of fibroblasts into hepatocyte-like cells by Kdm2b. Zakikhan K, Pournasr B, Nassiri-Asl M, Baharvand H. Biochem Biophys Res Commun. 2016 May 20;474(1):97-103. doi: 10.1016/j.bbrc.2016.04.076. Epub 2016 Apr 19. PubMed |
| Colorectal cancer cells display chaperone dependency for the unconventional prefoldin URI1. Lipinski KA, Britschgi C, Schrader K, Christinat Y, Frischknecht L, Krek W. Oncotarget. 2016 May 17;7(20):29635-47. doi: 10.18632/oncotarget.8816. PubMed |
| A convenient and effective strategy for the enrichment of tumor-initiating cell properties in prostate cancer cells. Zhang Y, Huang Y, Jin Z, Li X, Li B, Xu P, Huang P, Liu C. Tumour Biol. 2016 Apr 25. PubMed |
| An essential role for Grk2 in Hedgehog signalling downstream of Smoothened. Zhao Z, Lee RT, Pusapati GV, Iyu A, Rohatgi R, Ingham PW. EMBO Rep. 2016 May;17(5):739-52. doi: 10.15252/embr.201541532. Epub 2016 Apr 4. PubMed |
| The orphan nuclear receptor NR4A2 is part of a p53-microRNA-34 network. Beard JA, Tenga A, Hills J, Hoyer JD, Cherian MT, Wang YD, Chen T. Sci Rep. 2016 Apr 28;6:25108. doi: 10.1038/srep25108. PubMed |
Methods for Efficient Elimination of Mitochondrial DNA from Cultured Cells.
Spadafora D, Kozhukhar N, Chouljenko VN, Kousoulas KG, Alexeyev MF.
PLoS One. 2016 May 2;11(5):e0154684. doi: 10.1371/journal.pone.0154684. eCollection 2016.
PubMed
Associated Plasmids |
| Deletion of inositol hexakisphosphate kinase 1 (IP6K1) reduces cell migration and invasion, conferring protection from aerodigestive tract carcinoma in mice. Jadav RS, Kumar D, Buwa N, Ganguli S, Thampatty SR, Balasubramanian N, Bhandari R. Cell Signal. 2016 Aug;28(8):1124-36. doi: 10.1016/j.cellsig.2016.04.011. Epub 2016 Apr 30. PubMed |
TET2 Regulates Mast Cell Differentiation and Proliferation through Catalytic and Non-catalytic Activities.
Montagner S, Leoni C, Emming S, Della Chiara G, Balestrieri C, Barozzi I, Piccolo V, Togher S, Ko M, Rao A, Natoli G, Monticelli S.
Cell Rep. 2016 May 17;15(7):1566-79. doi: 10.1016/j.celrep.2016.04.044. Epub 2016 May 5.
PubMed
Associated Plasmids |
| The three Type 2A protein phosphatases, PP2Ac, PP4c and PP6c, are differentially regulated by Alpha4. LeNoue-Newton ML, Wadzinski BE, Spiller BW. Biochem Biophys Res Commun. 2016 Jun 17;475(1):64-9. doi: 10.1016/j.bbrc.2016.05.036. Epub 2016 May 8. PubMed |
| TFEB and TFE3 cooperate in the regulation of the innate immune response in activated macrophages. Pastore N, Brady OA, Diab HI, Martina JA, Sun L, Huynh T, Lim JA, Zare H, Raben N, Ballabio A, Puertollano R. Autophagy. 2016 May 12:1-19. PubMed |
| Targeting by AutophaGy proteins (TAG): Targeting of IFNG-inducible GTPases to membranes by the LC3 conjugation system of autophagy. Park S, Choi J, Biering SB, Dominici E, Williams LE, Hwang S. Autophagy. 2016 Jul 2;12(7):1153-67. doi: 10.1080/15548627.2016.1178447. Epub 2016 May 12. PubMed |
| The antitumor toxin CD437 is a direct inhibitor of DNA polymerase alpha. Han T, Goralski M, Capota E, Padrick SB, Kim J, Xie Y, Nijhawan D. Nat Chem Biol. 2016 Jul;12(7):511-5. doi: 10.1038/nchembio.2082. Epub 2016 May 16. PubMed |
| ISPD produces CDP-ribitol used by FKTN and FKRP to transfer ribitol phosphate onto alpha-dystroglycan. Gerin I, Ury B, Breloy I, Bouchet-Seraphin C, Bolsee J, Halbout M, Graff J, Vertommen D, Muccioli GG, Seta N, Cuisset JM, Dabaj I, Quijano-Roy S, Grahn A, Van Schaftingen E, Bommer GT. Nat Commun. 2016 May 19;7:11534. doi: 10.1038/ncomms11534. PubMed |
| Opposing Regulation of the EGF Receptor: A Molecular Switch Controlling Cytomegalovirus Latency and Replication. Buehler J, Zeltzer S, Reitsma J, Petrucelli A, Umashankar M, Rak M, Zagallo P, Schroeder J, Terhune S, Goodrum F. PLoS Pathog. 2016 May 24;12(5):e1005655. doi: 10.1371/journal.ppat.1005655. eCollection 2016 May. PubMed |
| Integrin alphavbeta3 enhances beta-catenin signaling in acute myeloid leukemia harboring Fms-like tyrosine kinase-3 internal tandem duplication mutations: implications for microenvironment influence on sorafenib sensitivity. Yi H, Zeng D, Shen Z, Liao J, Wang X, Liu Y, Zhang X, Kong P. Oncotarget. 2016 Jun 28;7(26):40387-40397. doi: 10.18632/oncotarget.9617. PubMed |
| A C-terminally truncated mouse Best3 splice variant targets and alters the ion balance in lysosome-endosome hybrids and the endoplasmic reticulum. Wu L, Sun Y, Ma L, Zhu J, Zhang B, Pan Q, Li Y, Liu H, Diao A, Li Y. Sci Rep. 2016 Jun 6;6:27332. doi: 10.1038/srep27332. PubMed |
| Atg7 suppression enhances chemotherapeutic agent sensitivity and overcomes stroma-mediated chemoresistance in acute myeloid leukemia. Piya S, Kornblau SM, Ruvolo VR, Mu H, Ruvolo PP, McQueen T, Davis RE, Hail N Jr, Kantarjian H, Andreeff M, Borthakur G. Blood. 2016 Jun 7. pii: blood-2016-01-692244. PubMed |
Probing the impact of chromatin conformation on genome editing tools.
Chen X, Rinsma M, Janssen JM, Liu J, Maggio I, Goncalves MA.
Nucleic Acids Res. 2016 Jun 8. pii: gkw524.
PubMed
Associated Plasmids |
Co-repressor CBFA2T2 regulates pluripotency and germline development.
Tu S, Narendra V, Yamaji M, Vidal SE, Rojas LA, Wang X, Kim SY, Garcia BA, Tuschl T, Stadtfeld M, Reinberg D.
Nature. 2016 Jun 8;534(7607):387-90. doi: 10.1038/nature18004.
PubMed
Associated Plasmids |
| Cell-death-inducing DFFA-like Effector B Contributes to the Assembly of Hepatitis C Virus (HCV) Particles and Interacts with HCV NS5A. Cai H, Yao W, Li L, Li X, Hu L, Mai R, Peng T. Sci Rep. 2016 Jun 10;6:27778. doi: 10.1038/srep27778. PubMed |
| TMEM16F Regulates Baseline Phosphatidylserine Exposure and Cell Viability in Human Embryonic Kidney Cells. Schenk LK, Schulze U, Henke S, Weide T, Pavenstadt H. Cell Physiol Biochem. 2016;38(6):2452-63. doi: 10.1159/000445596. Epub 2016 Jun 13. PubMed |
| N-cadherin is Key to Expression of the Nucleus Pulposus Cell Phenotype under Selective Substrate Culture Conditions. Hwang PY, Jing L, Chen J, Lim FL, Tang R, Choi H, Cheung KM, Risbud MV, Gersbach CA, Guilak F, Leung VY, Setton LA. Sci Rep. 2016 Jun 13;6:28038. doi: 10.1038/srep28038. PubMed |
| Suppression of Spleen Tyrosine Kinase (Syk) by Histone Deacetylation Promotes, Whereas BAY61-3606, a Synthetic Syk Inhibitor Abrogates Colonocyte Apoptosis by ERK Activation. Dasgupta N, Thakur BK, Ta A, Dutta P, Das S. J Cell Biochem. 2016 Jun 13. doi: 10.1002/jcb.25625. PubMed |
| Autocrine Complement Inhibits IL10-Dependent T-Cell Mediated Antitumor Immunity to Promote Tumor Progression. Wang Y, Sun SN, Liu Q, Yu YY, Guo J, Wang K, Xing BC, Zheng QF, Campa MJ, Patz EF, Li SY, He YW. Cancer Discov. 2016 Jun 13. pii: CD-15-1412. PubMed |
| MicroRNA-181b inhibits thrombin-mediated endothelial activation and arterial thrombosis by targeting caspase recruitment domain family member 10. Lin J, He S, Sun X, Franck G, Deng Y, Yang D, Haemmig S, Wara AK, Icli B, Li D, Feinberg MW. FASEB J. 2016 Jun 13. pii: fj.201500163R. PubMed |
| Preventing Plasmon Coupling between Gold Nanorods Improves the Sensitivity of Photoacoustic Detection of Labeled Stem Cells in Vivo. Comenge J, Fragueiro O, Sharkey J, Taylor A, Held M, Burton NC, Park BK, Wilm B, Murray P, Brust M, Levy R. ACS Nano. 2016 Jul 26;10(7):7106-16. doi: 10.1021/acsnano.6b03246. Epub 2016 Jun 20. PubMed |
AMPK-SKP2-CARM1 signalling cascade in transcriptional regulation of autophagy.
Shin HR, Kim H, Oh S, Lee JG, Kee M, Ko HJ, Kweon MN, Won KJ, Baek SH.
Nature. 2016 Jun 15. doi: 10.1038/nature18014.
PubMed
Associated Plasmids |
| Autophagy regulates spermatid differentiation via degradation of PDLIM1. Shang Y, Wang H, Jia P, Zhao H, Liu C, Liu W, Song Z, Xu Z, Yang L, Wang Y, Li W. Autophagy. 2016 Sep;12(9):1575-92. doi: 10.1080/15548627.2016.1192750. Epub 2016 Jun 16. PubMed |
| Hypoxia promotes noncanonical autophagy in nucleus pulposus cells independent of MTOR and HIF1A signaling. Choi H, Merceron C, Mangiavini L, Seifert EL, Schipani E, Shapiro IM, Risbud MV. Autophagy. 2016 Sep;12(9):1631-46. doi: 10.1080/15548627.2016.1192753. Epub 2016 Jun 17. PubMed |
| MicroRNA-17-92 regulates myoblast proliferation and differentiation by targeting the ENH1/Id1 signaling axis. Qiu H, Liu N, Luo L, Zhong J, Tang Z, Kang K, Qu J, Peng W, Liu L, Li L, Gou D. Cell Death Differ. 2016 Jun 17. doi: 10.1038/cdd.2016.56. PubMed |
| Conditional RNAi Using the Lentiviral GLTR System. Pfeiffenberger E, Sigl R, Geley S. Methods Mol Biol. 2016;1448:121-38. doi: 10.1007/978-1-4939-3753-0_10. PubMed |
| Dynamic Imaging Reveals Coordinate Effects of Cyclic Stretch and Substrate Stiffness on Endothelial Integrity. Dan A, Huang RB, Leckband DE. Ann Biomed Eng. 2016 Jun 17. PubMed |
| Chromatin remodeling gene AT-rich interactive domain-containing protein 1A suppresses gastric cancer cell proliferation by targeting PIK3CA and PDK1. Zhang Q, Yan HB, Wang J, Cui SJ, Wang XQ, Jiang YH, Feng L, Yang PY, Liu F. Oncotarget. 2016 Jul 19;7(29):46127-46141. doi: 10.18632/oncotarget.10060. PubMed |
| Agonist-Activated Bombyx Corazonin Receptor Is Internalized via an Arrestin-Dependent and Clathrin-Independent Pathway. Yang J, Shen Z, Jiang X, Yang H, Huang H, Jin L, Chen Y, Shi L, Zhou N. Biochemistry. 2016 Jul 19;55(28):3874-87. doi: 10.1021/acs.biochem.6b00250. Epub 2016 Jul 8. PubMed |
| Multiple genetically engineered humanized microenvironments in a single mouse. Lee J, Heckl D, Parekkadan B. Biomater Res. 2016 Jun 28;20:19. doi: 10.1186/s40824-016-0066-2. eCollection 2016. PubMed |
| Practical Considerations for Using Pooled Lentiviral CRISPR Libraries. McDade JR, Waxmonsky NC, Swanson LE, Fan M. Curr Protoc Mol Biol. 2016 Jul 1;115:31.5.1-31.5.13. doi: 10.1002/cpmb.8. PubMed |
| Evaluation of AD-MSC (adipose-derived mesenchymal stem cells) as a vehicle for IFN-beta delivery in experimental autoimmune encephalomyelitis. Mohammadzadeh A, Pourfathollah AA, Shahrokhi S, Fallah A, Tahoori MT, Amari A, Forouzandeh M, Soleimani M. Clin Immunol. 2016 Aug;169:98-106. doi: 10.1016/j.clim.2016.06.015. Epub 2016 Jul 1. PubMed |
| Methylphenidate-triggered ROS generation promotes caveolae-mediated transcytosis via Rac1 signaling and c-Src-dependent caveolin-1 phosphorylation in human brain endothelial cells. Coelho-Santos V, Socodato R, Portugal C, Leitao RA, Rito M, Barbosa M, Couraud PO, Romero IA, Weksler B, Minshall RD, Fontes-Ribeiro C, Summavielle T, Relvas JB, Silva AP. Cell Mol Life Sci. 2016 Dec;73(24):4701-4716. Epub 2016 Jul 4. PubMed |
| The Interferon-Stimulated Gene Ifitm3 Restricts West Nile Virus Infection and Pathogenesis. Gorman MJ, Poddar S, Farzan M, Diamond MS. J Virol. 2016 Aug 26;90(18):8212-25. doi: 10.1128/JVI.00581-16. Print 2016 Sep 15. PubMed |
| Halofuginone and artemisinin synergistically arrest cancer cells at the G1/G0 phase by upregulating p21Cip1 and p27Kip1. Chen G, Gong R, Shi X, Yang D, Zhang G, Lu A, Yue J, Bian Z. Oncotarget. 2016 Aug 2;7(31):50302-50314. doi: 10.18632/oncotarget.10367. PubMed |
| RNAi-mediated silencing of HLA A2 suppressed acute rejection against human fibroblast xenografts in the striatum of 6-OHDA lesioned rats. Liang C, Xu Y, Zheng D, Sun X, Xu Q, Duan D. J Neuroimmunol. 2016 Aug 15;297:28-37. doi: 10.1016/j.jneuroim.2016.05.002. Epub 2016 May 3. PubMed |
| Assessment of Anti-TNF-alpha Activities in Keratinocytes Expressing Inducible TNF- alpha: A Novel Tool for Anti-TNF-alpha Drug Screening. Udommethaporn S, Tencomnao T, McGowan EM, Boonyaratanakornkit V. PLoS One. 2016 Jul 14;11(7):e0159151. doi: 10.1371/journal.pone.0159151. eCollection 2016. PubMed |
| Transcription factor NFE2L2/NRF2 is a regulator of macroautophagy genes. Pajares M, Jimenez-Moreno N, Garcia-Yague AJ, Escoll M, de Ceballos ML, Van Leuven F, Rabano A, Yamamoto M, Rojo AI, Cuadrado A. Autophagy. 2016 Oct 2;12(10):1902-1916. Epub 2016 Jul 18. PubMed |
| The role of formyl peptide receptor 1 (FPR1) in neuroblastoma tumorigenesis. Snapkov I, Oqvist CO, Figenschau Y, Kogner P, Johnsen JI, Sveinbjornsson B. BMC Cancer. 2016 Jul 18;16:490. doi: 10.1186/s12885-016-2545-1. PubMed |
| A USP28-53BP1-p53-p21 signaling axis arrests growth after centrosome loss or prolonged mitosis. Lambrus BG, Daggubati V, Uetake Y, Scott PM, Clutario KM, Sluder G, Holland AJ. J Cell Biol. 2016 Jul 18;214(2):143-53. doi: 10.1083/jcb.201604054. PubMed |
| Epstein-Barr Virus Oncoprotein LMP1 Mediates Epigenetic Changes in Host Gene Expression through PARP1. Martin KA, Lupey LN, Tempera I. J Virol. 2016 Sep 12;90(19):8520-30. doi: 10.1128/JVI.01180-16. Print 2016 Oct 1. PubMed |
| The Interferon-Stimulated Gene IFITM3 Restricts Infection and Pathogenesis of Arthritogenic and Encephalitic Alphaviruses. Poddar S, Hyde JL, Gorman MJ, Farzan M, Diamond MS. J Virol. 2016 Sep 12;90(19):8780-94. doi: 10.1128/JVI.00655-16. Print 2016 Oct 1. PubMed |
| AMP-activated protein kinase is involved in the activation of the Fanconi anemia/BRCA pathway in response to DNA interstrand crosslinks. Chun MJ, Kim S, Hwang SK, Kim BS, Kim HG, Choi HI, Kim JH, Goh SH, Lee CH. Oncotarget. 2016 Aug 16;7(33):53642-53653. doi: 10.18632/oncotarget.10686. PubMed |
| VE-cadherin interacts with cell polarity protein Pals1 to regulate vascular lumen formation. Brinkmann BF, Steinbacher T, Hartmann C, Kummer D, Pajonczyk D, Mirzapourshafiyi F, Nakayama M, Weide T, Gerke V, Ebnet K. Mol Biol Cell. 2016 Sep 15;27(18):2811-21. doi: 10.1091/mbc.E16-02-0127. Epub 2016 Jul 27. PubMed |
| Ubiquitously expressed genes participate in cell-specific functions via alternative promoter usage. Feng G, Tong M, Xia B, Luo GZ, Wang M, Xie D, Wan H, Zhang Y, Zhou Q, Wang XJ. EMBO Rep. 2016 Sep;17(9):1304-13. doi: 10.15252/embr.201541476. Epub 2016 Jul 27. PubMed |
| Prevention of Proliferative Vitreoretinopathy by Suppression of Phosphatidylinositol 5-Phosphate 4-Kinases. Ma G, Duan Y, Huang X, Qian CX, Chee Y, Mukai S, Cui J, Samad A, Matsubara JA, Kazlauskas A, D'Amore PA, Gu S, Lei H. Invest Ophthalmol Vis Sci. 2016 Jul 1;57(8):3935-43. doi: 10.1167/iovs.16-19405. PubMed |
| EZH2-mediated Puma gene repression regulates non-small cell lung cancer cell proliferation and cisplatin-induced apoptosis. Liu H, Li W, Yu X, Gao F, Duan Z, Ma X, Tan S, Yuan Y, Liu L, Wang J, Zhou X, Yang Y. Oncotarget. 2016 Aug 30;7(35):56338-56354. doi: 10.18632/oncotarget.10841. PubMed |
| Regulation of B-cell development and tolerance by different members of the miR-17 approximately 92 family microRNAs. Lai M, Gonzalez-Martin A, Cooper AB, Oda H, Jin HY, Shepherd J, He L, Zhu J, Nemazee D, Xiao C. Nat Commun. 2016 Aug 2;7:12207. doi: 10.1038/ncomms12207. PubMed |
| Microfluidic device for the formation of optically excitable, three-dimensional, compartmentalized motor units. Uzel SG, Platt RJ, Subramanian V, Pearl TM, Rowlands CJ, Chan V, Boyer LA, So PT, Kamm RD. Sci Adv. 2016 Aug 3;2(8):e1501429. doi: 10.1126/sciadv.1501429. eCollection 2016 Aug. PubMed |
| Protocol for the Direct Conversion of Murine Embryonic Fibroblasts into Trophoblast Stem Cells. Kubaczka C, Schorle H. J Vis Exp. 2016 Jul 25;(113). doi: 10.3791/54277. PubMed |
| CXCR4 Overexpression in Human Adipose Tissue-Derived Stem Cells Improves Homing and Engraftment in an Animal Limb Ischemia Model. Kim M, Kim DI, Kim EK, Kim CW. Cell Transplant. 2017 Feb 16;26(2):191-204. doi: 10.3727/096368916X692708. Epub 2016 Aug 5. PubMed |
| The RNA-Binding Protein, Polypyrimidine Tract-Binding Protein 1 (PTBP1) Is a Key Regulator of CD4 T Cell Activation. La Porta J, Matus-Nicodemos R, Valentin-Acevedo A, Covey LR. PLoS One. 2016 Aug 11;11(8):e0158708. doi: 10.1371/journal.pone.0158708. eCollection 2016. PubMed |
| MCPIP-1, Alias Regnase-1, Controls Epithelial Inflammation by Posttranscriptional Regulation of IL-8 Production. Dobosz E, Wilamowski M, Lech M, Bugara B, Jura J, Potempa J, Koziel J. J Innate Immun. 2016;8(6):564-578. Epub 2016 Aug 12. PubMed |
| PTEN loss is associated with a poor response to trastuzumab in HER2-overexpressing gastroesophageal adenocarcinoma. Deguchi Y, Okabe H, Oshima N, Hisamori S, Minamiguchi S, Muto M, Sakai Y. Gastric Cancer. 2016 Aug 12. PubMed |
| PPP2R5B, a regulatory subunit of PP2A, contributes to adipocyte insulin resistance. Beg M, Srivastava A, Shankar K, Varshney S, Rajan S, Gupta A, Kumar D, Gaikwad AN. Mol Cell Endocrinol. 2016 Dec 5;437:97-107. doi: 10.1016/j.mce.2016.08.016. Epub 2016 Aug 10. PubMed |
| Negative Feedback Regulation of HIV-1 by Gene Editing Strategy. Kaminski R, Chen Y, Salkind J, Bella R, Young WB, Ferrante P, Karn J, Malcolm T, Hu W, Khalili K. Sci Rep. 2016 Aug 16;6:31527. doi: 10.1038/srep31527. PubMed |
| BNIP3 Protein Suppresses PINK1 Kinase Proteolytic Cleavage to Promote Mitophagy. Zhang T, Xue L, Li L, Tang C, Wan Z, Wang R, Tan J, Tan Y, Han H, Tian R, Billiar TR, Tao WA, Zhang Z. J Biol Chem. 2016 Oct 7;291(41):21616-21629. Epub 2016 Aug 15. PubMed |
| Exposure to human immunodeficiency virus/hepatitis C virus in hepatic and stellate cell lines reveals cooperative profibrotic transcriptional activation between viruses and cell types. Salloum S, Holmes JA, Jindal R, Bale SS, Brisac C, Alatrakchi N, Lidofsky A, Kruger AJ, Fusco DN, Luther J, Schaefer EA, Lin W, Yarmush ML, Chung RT. Hepatology. 2016 Dec;64(6):1951-1968. doi: 10.1002/hep.28766. Epub 2016 Oct 5. PubMed |
| Novel biomarkers of resistance of pancreatic cancer cells to oncolytic vesicular stomatitis virus. Hastie E, Cataldi M, Moerdyk-Schauwecker MJ, Felt SA, Steuerwald N, Grdzelishvili VZ. Oncotarget. 2016 Sep 20;7(38):61601-61618. doi: 10.18632/oncotarget.11202. PubMed |
| Long noncoding RNA C17orf91 is a potential prognostic marker and functions as an oncogene in ovarian cancer. Li J, Yu H, Xi M, Lu X. J Ovarian Res. 2016 Aug 17;9(1):49. doi: 10.1186/s13048-016-0258-3. PubMed |
| TSC2 N-terminal lysine acetylation status affects to its stability modulating mTORC1 signaling and autophagy. Garcia-Aguilar A, Guillen C, Nellist M, Bartolome A, Benito M. Biochim Biophys Acta. 2016 Nov;1863(11):2658-2667. doi: 10.1016/j.bbamcr.2016.08.006. Epub 2016 Aug 16. PubMed |
| Protein phosphatase 2A regulatory subunit B56beta modulates erythroid differentiation. Wu J, Wang J, Zeng X, Chen Y, Xia J, Wang S, Huang Z, Chen W, Shen Z. Biochem Biophys Res Commun. 2016 Sep 23;478(3):1179-84. doi: 10.1016/j.bbrc.2016.08.090. Epub 2016 Aug 17. PubMed |
| Telomerase reverse transcriptase induces basal and amino acid starvation-induced autophagy through mTORC1. Ali M, Devkota S, Roh JI, Lee J, Lee HW. Biochem Biophys Res Commun. 2016 Sep 23;478(3):1198-204. doi: 10.1016/j.bbrc.2016.08.094. Epub 2016 Aug 18. PubMed |
| Method for Efficient Transduction of Cancer Stem Cells. Walker K, Hjelmeland A. J Cancer Stem Cell Res. 2014;2. pii: e1008. Epub 2014 Dec 1. PubMed |
| A Role for Nuclear F-Actin Induction in Human Cytomegalovirus Nuclear Egress. Wilkie AR, Lawler JL, Coen DM. MBio. 2016 Aug 23;7(4). pii: e01254-16. doi: 10.1128/mBio.01254-16. PubMed |
| Cell-Type-Specific Alternative Splicing Governs Cell Fate in the Developing Cerebral Cortex. Zhang X, Chen MH, Wu X, Kodani A, Fan J, Doan R, Ozawa M, Ma J, Yoshida N, Reiter JF, Black DL, Kharchenko PV, Sharp PA, Walsh CA. Cell. 2016 Aug 25;166(5):1147-1162.e15. doi: 10.1016/j.cell.2016.07.025. PubMed |
| Comprehensive Classification of Retinal Bipolar Neurons by Single-Cell Transcriptomics. Shekhar K, Lapan SW, Whitney IE, Tran NM, Macosko EZ, Kowalczyk M, Adiconis X, Levin JZ, Nemesh J, Goldman M, McCarroll SA, Cepko CL, Regev A, Sanes JR. Cell. 2016 Aug 25;166(5):1308-1323.e30. doi: 10.1016/j.cell.2016.07.054. PubMed |
| A method to convert mRNA into a gRNA library for CRISPR/Cas9 editing of any organism. Arakawa H. Sci Adv. 2016 Aug 24;2(8):e1600699. doi: 10.1126/sciadv.1600699. eCollection 2016 Aug. PubMed |
| Histone H3K27 Trimethylation Modulates 5-Fluorouracil Resistance by Inhibiting PU.1 Binding to the DPYD Promoter. Wu R, Nie Q, Tapper EE, Jerde CR, Dunlap GS, Shrestha S, Elraiyah TA, Offer SM, Diasio RB. Cancer Res. 2016 Nov 1;76(21):6362-6373. Epub 2016 Aug 30. PubMed |
| Natural Killer Cell Evasion Is Essential for Infection by Rhesus Cytomegalovirus. Sturgill ER, Malouli D, Hansen SG, Burwitz BJ, Seo S, Schneider CL, Womack JL, Verweij MC, Ventura AB, Bhusari A, Jeffries KM, Legasse AW, Axthelm MK, Hudson AW, Sacha JB, Picker LJ, Fruh K. PLoS Pathog. 2016 Aug 31;12(8):e1005868. doi: 10.1371/journal.ppat.1005868. eCollection 2016 Aug. PubMed |
| High-Throughput Screening of Tyrosine Kinase Inhibitor Resistant Genes in CML. Ma L, Roderick J, Kelliher MA, Green MR. Methods Mol Biol. 2016;1465:159-73. doi: 10.1007/978-1-4939-4011-0_14. PubMed |
| Roles for E-cadherin cell surface regulation in cancer. Petrova YI, Schecterson L, Gumbiner BM. Mol Biol Cell. 2016 Nov 1;27(21):3233-3244. Epub 2016 Aug 31. PubMed |
| Methods to Manipulate and Monitor Wnt Signaling in Human Pluripotent Stem Cells. Huggins IJ, Brafman D, Willert K. Methods Mol Biol. 2016;1481:161-81. doi: 10.1007/978-1-4939-6393-5_16. PubMed |
| Deregulation of the Hippo pathway in mouse mammary stem cells promotes mammary tumorigenesis. Li H, Gumbiner BM. Mamm Genome. 2016 Dec;27(11-12):556-564. Epub 2016 Sep 6. PubMed |
| PtdIns(4,5)P2 signaling regulates ATG14 and autophagy. Tan X, Thapa N, Liao Y, Choi S, Anderson RA. Proc Natl Acad Sci U S A. 2016 Sep 27;113(39):10896-901. doi: 10.1073/pnas.1523145113. Epub 2016 Sep 12. PubMed |
| Tbx3 fosters pancreatic cancer growth by increased angiogenesis and activin/nodal-dependent induction of stemness. Perkhofer L, Walter K, Costa IG, Carrasco MC, Eiseler T, Hafner S, Genze F, Zenke M, Bergmann W, Illing A, Hohwieler M, Kohntop R, Lin Q, Holzmann KH, Seufferlein T, Wagner M, Liebau S, Hermann PC, Kleger A, Muller M. Stem Cell Res. 2016 Sep;17(2):367-378. doi: 10.1016/j.scr.2016.08.007. Epub 2016 Aug 10. PubMed |
| Long non-coding RNA H19 enhances cell proliferation and anchorage-independent growth of cervical cancer cell lines. Iempridee T. Exp Biol Med (Maywood). 2017 Jan;242(2):184-193. doi: 10.1177/1535370216670542. Epub 2016 Oct 4. PubMed |
| Involvement of peroxisome proliferator activated receptor-gamma in the anti-inflammatory effects of atorvastatin in oxygen-glucose deprivation/reperfusion-stimulated RAW264.7 murine macrophages. Li HY, Su YY, Zhang YF, Liu ZQ, Hua BJ. Mol Med Rep. 2016 Nov;14(5):4055-4062. doi: 10.3892/mmr.2016.5742. Epub 2016 Sep 15. PubMed |
| Chronic Kappa opioid receptor activation modulates NR2B: Implication in treatment resistant depression. Dogra S, Kumar A, Umrao D, Sahasrabuddhe AA, Yadav PN. Sci Rep. 2016 Sep 16;6:33401. doi: 10.1038/srep33401. PubMed |
| An alternative splicing program promotes adipose tissue thermogenesis. Vernia S, Edwards YJ, Han MS, Cavanagh-Kyros J, Barrett T, Kim JK, Davis RJ. Elife. 2016 Sep 16;5. pii: e17672. doi: 10.7554/eLife.17672. PubMed |
| Localized translation regulates cell adhesion and transendothelial migration. Bergeman J, Caillier A, Houle F, Gagne LM, Huot ME. J Cell Sci. 2016 Nov 1;129(21):4105-4117. Epub 2016 Sep 16. PubMed |
| Sindbis Virus-Pseudotyped Lentiviral Vectors Carrying VEGFR2-Specific Nanobody for Potential Transductional Targeting of Tumor Vasculature. Ahani R, Roohvand F, Cohan RA, Etemadzadeh MH, Mohajel N, Behdani M, Shahosseini Z, Madani N, Azadmanesh K. Mol Biotechnol. 2016 Nov;58(11):738-747. PubMed |
| Targeting the metabolic pathway of human colon cancer overcomes resistance to TRAIL-induced apoptosis. Carr RM, Qiao G, Qin J, Jayaraman S, Prabhakar BS, Maker AV. Cell Death Discov. 2016 Sep 12;2:16067. doi: 10.1038/cddiscovery.2016.67. eCollection 2016. PubMed |
| Cadm3 (Necl-1) interferes with the activation of the PI3 kinase/Akt signaling cascade and inhibits Schwann cell myelination in vitro. Chen MS, Kim H, Jagot-Lacoussiere L, Maurel P. Glia. 2016 Dec;64(12):2247-2262. doi: 10.1002/glia.23072. Epub 2016 Sep 23. PubMed |
| PD-1 mediates functional exhaustion of activated NK cells in patients with Kaposi sarcoma. Beldi-Ferchiou A, Lambert M, Dogniaux S, Vely F, Vivier E, Olive D, Dupuy S, Levasseur F, Zucman D, Lebbe C, Sene D, Hivroz C, Caillat-Zucman S. Oncotarget. 2016 Nov 8;7(45):72961-72977. doi: 10.18632/oncotarget.12150. PubMed |
| Endogenous TRPV1 stimulation leads to the activation of the inositol phospholipid pathway necessary for sustained Ca2+ oscillations. Pecze L, Blum W, Henzi T, Schwaller B. Biochim Biophys Acta. 2016 Dec;1863(12):2905-2915. doi: 10.1016/j.bbamcr.2016.09.013. Epub 2016 Sep 20. PubMed |
| AEG-1 promotes mesenchymal transition through the activation of Rho GTPases in human glioblastoma cells. Park SY, Choi M, Park D, Jeong M, Ahn KS, Lee J, Fisher PB, Yun M, Lee SG. Oncol Rep. 2016 Nov;36(5):2641-2646. doi: 10.3892/or.2016.5106. Epub 2016 Sep 19. PubMed |
| Gene expression elucidates functional impact of polygenic risk for schizophrenia. Fromer M, Roussos P, Sieberts SK, Johnson JS, Kavanagh DH, Perumal TM, Ruderfer DM, Oh EC, Topol A, Shah HR, Klei LL, Kramer R, Pinto D, Gumus ZH, Cicek AE, Dang KK, Browne A, Lu C, Xie L, Readhead B, Stahl EA, Xiao J, Parvizi M, Hamamsy T, Fullard JF, Wang YC, Mahajan MC, Derry JM, Dudley JT, Hemby SE, Logsdon BA, Talbot K, Raj T, Bennett DA, De Jager PL, Zhu J, Zhang B, Sullivan PF, Chess A, Purcell SM, Shinobu LA, Mangravite LM, Toyoshiba H, Gur RE, Hahn CG, Lewis DA, Haroutunian V, Peters MA, Lipska BK, Buxbaum JD, Schadt EE, Hirai K, Roeder K, Brennand KJ, Katsanis N, Domenici E, Devlin B, Sklar P. Nat Neurosci. 2016 Nov;19(11):1442-1453. doi: 10.1038/nn.4399. Epub 2016 Sep 26. PubMed |
| SPINK6 Promotes Metastasis of Nasopharyngeal Carcinoma via Binding and Activation of Epithelial Growth Factor Receptor. Zheng LS, Yang JP, Cao Y, Peng LX, Sun R, Xie P, Wang MY, Meng DF, Luo DH, Zou X, Chen MY, Mai HQ, Guo L, Guo X, Shao JY, Huang BJ, Zhang W, Qian CN. Cancer Res. 2017 Jan 15;77(2):579-589. doi: 10.1158/0008-5472.CAN-16-1281. Epub 2016 Sep 26. PubMed |
| mTOR and neuronal cell cycle reentry: How impaired brain insulin signaling promotes Alzheimer's disease. Norambuena A, Wallrabe H, McMahon L, Silva A, Swanson E, Khan SS, Baerthlein D, Kodis E, Oddo S, Mandell JW, Bloom GS. Alzheimers Dement. 2016 Sep 29. pii: S1552-5260(16)32895-3. doi: 10.1016/j.jalz.2016.08.015. PubMed |
| Glucocorticoid-induced leucine zipper (GILZ) is involved in glucocorticoid-induced and mineralocorticoid-induced leptin production by osteoarthritis synovial fibroblasts. Malaise O, Relic B, Charlier E, Zeddou M, Neuville S, Deroyer C, Gillet P, Louis E, Malaise MG, de Seny D. Arthritis Res Ther. 2016 Oct 4;18(1):219. PubMed |
| Construction of Conveniently Screening pLKO.1-TRC Vector Tagged with TurboGFP. Xu J, Zhu W, Guo Y, Jiang C, Hussain N, Meng L, Lu S. Appl Biochem Biotechnol. 2016 Oct 11. PubMed |
| L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity. Geiger R, Rieckmann JC, Wolf T, Basso C, Feng Y, Fuhrer T, Kogadeeva M, Picotti P, Meissner F, Mann M, Zamboni N, Sallusto F, Lanzavecchia A. Cell. 2016 Oct 20;167(3):829-842.e13. doi: 10.1016/j.cell.2016.09.031. Epub 2016 Oct 13. PubMed |
| Snail1-dependent p53 repression regulates expansion and activity of tumour-initiating cells in breast cancer. Ni T, Li XY, Lu N, An T, Liu ZP, Fu R, Lv WC, Zhang YW, Xu XJ, Grant Rowe R, Lin YS, Scherer A, Feinberg T, Zheng XQ, Chen BA, Liu XS, Guo QL, Wu ZQ, Weiss SJ. Nat Cell Biol. 2016 Nov;18(11):1221-1232. doi: 10.1038/ncb3425. Epub 2016 Oct 17. PubMed |
| Engineering prokaryotic channels for control of mammalian tissue excitability. Nguyen HX, Kirkton RD, Bursac N. Nat Commun. 2016 Oct 18;7:13132. doi: 10.1038/ncomms13132. PubMed |
| A pH- and ionic strength-dependent conformational change in the neck region regulates DNGR-1 function in dendritic cells. Hanc P, Schulz O, Fischbach H, Martin SR, Kjaer S, Reis E Sousa C. EMBO J. 2016 Nov 15;35(22):2484-2497. Epub 2016 Oct 17. PubMed |
| Single Amino Acid Substitution N659D in HIV-2 Envelope Glycoprotein (Env) Impairs Viral Release and Hampers BST-2 Antagonism. Dufrasne FE, Lombard C, Goubau P, Ruelle J. Viruses. 2016 Oct 14;8(10). pii: E285. PubMed |
| SIKs control osteocyte responses to parathyroid hormone. Wein MN, Liang Y, Goransson O, Sundberg TB, Wang J, Williams EA, O'Meara MJ, Govea N, Beqo B, Nishimori S, Nagano K, Brooks DJ, Martins JS, Corbin B, Anselmo A, Sadreyev R, Wu JY, Sakamoto K, Foretz M, Xavier RJ, Baron R, Bouxsein ML, Gardella TJ, Divieti-Pajevic P, Gray NS, Kronenberg HM. Nat Commun. 2016 Oct 19;7:13176. doi: 10.1038/ncomms13176. PubMed |
| Methylglyoxal, a glycolysis side-product, induces Hsp90 glycation and YAP-mediated tumor growth and metastasis. Nokin MJ, Durieux F, Peixoto P, Chiavarina B, Peulen O, Blomme A, Turtoi A, Costanza B, Smargiasso N, Baiwir D, Scheijen JL, Schalkwijk CG, Leenders J, De Tullio P, Bianchi E, Thiry M, Uchida K, Spiegel DA, Cochrane JR, Hutton CA, De Pauw E, Delvenne P, Belpomme D, Castronovo V, Bellahcene A. Elife. 2016 Oct 19;5. pii: e19375. doi: 10.7554/eLife.19375. PubMed |
| Chromosome conformation elucidates regulatory relationships in developing human brain. Won H, de la Torre-Ubieta L, Stein JL, Parikshak NN, Huang J, Opland CK, Gandal MJ, Sutton GJ, Hormozdiari F, Lu D, Lee C, Eskin E, Voineagu I, Ernst J, Geschwind DH. Nature. 2016 Oct 27;538(7626):523-527. doi: 10.1038/nature19847. Epub 2016 Oct 19. PubMed |
| Complementary Roles of Estrogen-Related Receptors in Brown Adipocyte Thermogenic Function. Gantner ML, Hazen BC, Eury E, Brown EL, Kralli A. Endocrinology. 2016 Dec;157(12):4770-4781. Epub 2016 Oct 20. PubMed |
| RNA-binding protein QKI-5 inhibits the proliferation of clear cell renal cell carcinoma via post-transcriptional stabilization of RASA1 mRNA. Zhang RL, Yang JP, Peng LX, Zheng LS, Xie P, Wang MY, Cao Y, Zhang ZL, Zhou FJ, Qian CN, Bao YX. Cell Cycle. 2016 Nov 16;15(22):3094-3104. Epub 2016 Oct 21. PubMed |
| Toxic PR Poly-Dipeptides Encoded by the C9orf72 Repeat Expansion Target LC Domain Polymers. Lin Y, Mori E, Kato M, Xiang S, Wu L, Kwon I, McKnight SL. Cell. 2016 Oct 20;167(3):789-802.e12. doi: 10.1016/j.cell.2016.10.003. PubMed |
| Role of FAST Kinase Domains 3 (FASTKD3) in Post-transcriptional Regulation of Mitochondrial Gene Expression. Boehm E, Zornoza M, Jourdain AA, Delmiro Magdalena A, Garcia-Consuegra I, Torres Merino R, Orduna A, Martin MA, Martinou JC, De la Fuente MA, Simarro M. J Biol Chem. 2016 Dec 9;291(50):25877-25887. Epub 2016 Oct 27. PubMed |
| Eomeshi NK Cells in Human Liver Are Long-Lived and Do Not Recirculate but Can Be Replenished from the Circulation. Cuff AO, Robertson FP, Stegmann KA, Pallett LJ, Maini MK, Davidson BR, Male V. J Immunol. 2016 Dec 1;197(11):4283-4291. Epub 2016 Oct 21. PubMed |
| The role of gigaxonin in the degradation of the glial-specific intermediate filament protein GFAP. Lin NH, Huang YS, Opal P, Goldman RD, Messing A, Perng MD. Mol Biol Cell. 2016 Dec 15;27(25):3980-3990. Epub 2016 Oct 26. PubMed |
| Inhibiting Extracellular Vesicle Release from Human Cardiosphere Derived Cells with Lentiviral Knockdown of nSMase2 Differentially Effects Proliferation and Apoptosis in Cardiomyocytes, Fibroblasts and Endothelial Cells In Vitro. Lang JK, Young RF, Ashraf H, Canty JM Jr. PLoS One. 2016 Nov 2;11(11):e0165926. doi: 10.1371/journal.pone.0165926. eCollection 2016. PubMed |
| Developmental mechanisms of stripe patterns in rodents. Mallarino R, Henegar C, Mirasierra M, Manceau M, Schradin C, Vallejo M, Beronja S, Barsh GS, Hoekstra HE. Nature. 2016 Nov 24;539(7630):518-523. doi: 10.1038/nature20109. Epub 2016 Nov 2. PubMed |
| TIM-1 Promotes Hepatitis C Virus Cell Attachment and Infection. Wang J, Qiao L, Hou Z, Luo G. J Virol. 2017 Jan 3;91(2). pii: e01583-16. doi: 10.1128/JVI.01583-16. Print 2017 Jan 15. PubMed |
| CRISPR/Cas9 editing of induced pluripotent stem cells for engineering inflammation-resistant tissues. Brunger JM, Zutshi A, Willard VP, Gersbach CA, Guilak F. Arthritis Rheumatol. 2016 Nov 3. doi: 10.1002/art.39982. PubMed |
| PAX6 regulates human corneal epithelium cell identity. Kitazawa K, Hikichi T, Nakamura T, Sotozono C, Kinoshita S, Masui S. Exp Eye Res. 2016 Nov 3;154:30-38. doi: 10.1016/j.exer.2016.11.005. PubMed |
| Direct reprogramming of fibroblasts into renal tubular epithelial cells by defined transcription factors. Kaminski MM, Tosic J, Kresbach C, Engel H, Klockenbusch J, Muller AL, Pichler R, Grahammer F, Kretz O, Huber TB, Walz G, Arnold SJ, Lienkamp SS. Nat Cell Biol. 2016 Dec;18(12):1269-1280. doi: 10.1038/ncb3437. Epub 2016 Nov 7. PubMed |
| Human 15-lipoxygenase-1 is a regulator of dendritic-cell spreading and podosome formation. Han H, Liang X, Ekberg M, Kritikou JS, Brunnstrom A, Pelcman B, Matl M, Miao X, Andersson M, Yuan X, Schain F, Parvin S, Melin E, Sjoberg J, Xu D, Westerberg LS, Bjorkholm M, Claesson HE. FASEB J. 2016 Oct 17. pii: fj.201600679RR. PubMed |
| Fluorescence Reporter-Based Genome-Wide RNA Interference Screening to Identify Alternative Splicing Regulators. Misra A, Green MR. Methods Mol Biol. 2017;1507:1-12. PubMed |
| Targeted depletion of PIK3R2 induces regression of lung squamous cell carcinoma. Vallejo-Diaz J, Olazabal-Moran M, Cariaga-Martinez AE, Pajares MJ, Flores JM, Pio R, Montuenga LM, Carrera AC. Oncotarget. 2016 Dec 20;7(51):85063-85078. doi: 10.18632/oncotarget.13195. PubMed |
| Tumors overexpressing RNF168 show altered DNA repair and responses to genotoxic treatments, genomic instability and resistance to proteotoxic stress. Chroma K, Mistrik M, Moudry P, Gursky J, Liptay M, Strauss R, Skrott Z, Vrtel R, Bartkova J, Kramara J, Bartek J. Oncogene. 2016 Nov 14. doi: 10.1038/onc.2016.392. PubMed |
| Dual loss of succinate dehydrogenase (SDH) and complex I activity is necessary to recapitulate the metabolic phenotype of SDH mutant tumors. Lorendeau D, Rinaldi G, Boon R, Spincemaille P, Metzger K, Jager C, Christen S, Dong X, Kuenen S, Voordeckers K, Verstreken P, Cassiman D, Vermeersch P, Verfaillie C, Hiller K, Fendt SM. Metab Eng. 2016 Nov 12. pii: S1096-7176(16)30217-8. doi: 10.1016/j.ymben.2016.11.005. PubMed |
| SPRTN is a mammalian DNA-binding metalloprotease that resolves DNA-protein crosslinks. Lopez-Mosqueda J, Maddi K, Prgomet S, Kalayil S, Marinovic-Terzic I, Terzic J, Dikic I. Elife. 2016 Nov 17;5. pii: e21491. doi: 10.7554/eLife.21491. PubMed |
| Knockdown of PTRF ameliorates adipocyte differentiation and functionality of human mesenchymal stem cells. Perez-Diaz S, Garcia-Rodriguez B, Gonzalez-Irazabal Y, Valero M, Lagos-Lizan J, Arbones-Mainar JM. Am J Physiol Cell Physiol. 2017 Jan 1;312(1):C83-C91. doi: 10.1152/ajpcell.00246.2016. Epub 2016 Nov 16. PubMed |
| Modularized Gold Nanocarriers for TAT-Mediated Delivery of siRNA. Huang X, Lai Y, Braun GB, Reich NO. Small. 2016 Nov 18. doi: 10.1002/smll.201602473. PubMed |
| Emerin suppresses Notch signaling by restricting the Notch intracellular domain to the nuclear membrane. Lee B, Lee TH, Shim J. Biochim Biophys Acta. 2017 Feb;1864(2):303-313. doi: 10.1016/j.bbamcr.2016.11.013. Epub 2016 Nov 16. PubMed |
| Pan-cancer analysis of somatic copy-number alterations implicates IRS4 and IGF2 in enhancer hijacking. Weischenfeldt J, Dubash T, Drainas AP, Mardin BR, Chen Y, Stutz AM, Waszak SM, Bosco G, Halvorsen AR, Raeder B, Efthymiopoulos T, Erkek S, Siegl C, Brenner H, Brustugun OT, Dieter SM, Northcott PA, Petersen I, Pfister SM, Schneider M, Solberg SK, Thunissen E, Weichert W, Zichner T, Thomas R, Peifer M, Helland A, Ball CR, Jechlinger M, Sotillo R, Glimm H, Korbel JO. Nat Genet. 2017 Jan;49(1):65-74. doi: 10.1038/ng.3722. Epub 2016 Nov 21. PubMed |
| RNA Sequencing Reveals a Role of TonEBP Transcription Factor in Regulation of Pro-inflammatory Genes in Response to Hyperosmolarity in Healthy Nucleus Pulposus Cells: A HOMEOSTATIC RESPONSE? Johnson ZI, Shapiro IM, Risbud MV. J Biol Chem. 2016 Dec 23;291(52):26686-26697. doi: 10.1074/jbc.M116.757732. Epub 2016 Nov 8. PubMed |
| Merkel Cell Polyomavirus Small T Antigen Promotes Pro-Glycolytic Metabolic Perturbations Required for Transformation. Berrios C, Padi M, Keibler MA, Park DE, Molla V, Cheng J, Lee SM, Stephanopoulos G, Quackenbush J, DeCaprio JA. PLoS Pathog. 2016 Nov 23;12(11):e1006020. doi: 10.1371/journal.ppat.1006020. eCollection 2016 Nov. PubMed |
| Cell-Type-Specific Chromatin States Differentially Prime Squamous Cell Carcinoma Tumor-Initiating Cells for Epithelial to Mesenchymal Transition. Latil M, Nassar D, Beck B, Boumahdi S, Wang L, Brisebarre A, Dubois C, Nkusi E, Lenglez S, Checinska A, Vercauteren Drubbel A, Devos M, Declercq W, Yi R, Blanpain C. Cell Stem Cell. 2016 Nov 16. pii: S1934-5909(16)30359-9. doi: 10.1016/j.stem.2016.10.018. PubMed |
| Scleraxis is essential for tendon differentiation by equine embryonic stem cells and in equine fetal tenocytes. Bavin E, Atkinson F, Barsby T, Guest D. Stem Cells Dev. 2016 Nov 29. PubMed |
| p53 signaling modulation of cell cycle arrest and viral replication in porcine circovirus type 2 infection cells. Xu D, Du Q, Han C, Wang Z, Zhang X, Wang T, Zhao X, Huang Y, Tong D. Vet Res. 2016 Nov 29;47(1):120. PubMed |
| Intravital imaging of mouse urothelium reveals activation of extracellular signal-regulated kinase by stretch-induced intravesical release of ATP. Sano T, Kobayashi T, Negoro H, Sengiku A, Hiratsuka T, Kamioka Y, Liou LS, Ogawa O, Matsuda M. Physiol Rep. 2016 Nov;4(21). pii: e13033. Epub 2016 Nov 15. PubMed |
| LncBRM initiates YAP1 signalling activation to drive self-renewal of liver cancer stem cells. Zhu P, Wang Y, Wu J, Huang G, Liu B, Ye B, Du Y, Gao G, Tian Y, He L, Fan Z. Nat Commun. 2016 Dec 1;7:13608. doi: 10.1038/ncomms13608. PubMed |
| Molecular imaging with engineered physiology. Desai M, Slusarczyk AL, Chapin A, Barch M, Jasanoff A. Nat Commun. 2016 Dec 2;7:13607. doi: 10.1038/ncomms13607. PubMed |
| The tumor suppressor FLCN mediates an alternate mTOR pathway to regulate browning of adipose tissue. Wada S, Neinast M, Jang C, Ibrahim YH, Lee G, Babu A, Li J, Hoshino A, Rowe GC, Rhee J, Martina JA, Puertollano R, Blenis J, Morley M, Baur JA, Seale P, Arany Z. Genes Dev. 2016 Nov 15;30(22):2551-2564. Epub 2016 Dec 2. PubMed |
| Tuberous sclerosis complex inactivation disrupts melanogenesis via mTORC1 activation. Cao J, Tyburczy ME, Moss J, Darling TN, Widlund HR, Kwiatkowski DJ. J Clin Invest. 2017 Jan 3;127(1):349-364. doi: 10.1172/JCI84262. Epub 2016 Dec 5. PubMed |
| hMYH and hMTH1 cooperate for survival in mismatch repair defective T-cell acute lymphoblastic leukemia. Eshtad S, Mavajian Z, Rudd SG, Visnes T, Bostrom J, Altun M, Helleday T. Oncogenesis. 2016 Dec 5;5(12):e275. doi: 10.1038/oncsis.2016.72. PubMed |
| Acidic tumor microenvironment abrogates the efficacy of mTORC1 inhibitors. Faes S, Duval AP, Planche A, Uldry E, Santoro T, Pythoud C, Stehle JC, Horlbeck J, Letovanec I, Riggi N, Demartines N, Dormond O. Mol Cancer. 2016 Dec 5;15(1):78. PubMed |
| PET imaging-guided chemogenetic silencing reveals a critical role of primate rostromedial caudate in reward evaluation. Nagai Y, Kikuchi E, Lerchner W, Inoue KI, Ji B, Eldridge MA, Kaneko H, Kimura Y, Oh-Nishi A, Hori Y, Kato Y, Hirabayashi T, Fujimoto A, Kumata K, Zhang MR, Aoki I, Suhara T, Higuchi M, Takada M, Richmond BJ, Minamimoto T. Nat Commun. 2016 Dec 6;7:13605. doi: 10.1038/ncomms13605. PubMed |
| SFPQ*NONO and XLF function separately and together to promote DNA double-strand break repair via canonical nonhomologous end joining. Jaafar L, Li Z, Li S, Dynan WS. Nucleic Acids Res. 2016 Dec 6. pii: gkw1209. PubMed |
| EGF induces epithelial-mesenchymal transition and cancer stem-like cell properties in human oral cancer cells via promoting Warburg effect. Xu Q, Zhang Q, Ishida Y, Hajjar S, Tang X, Shi H, Dang CV, Le AD. Oncotarget. 2017 Feb 7;8(6):9557-9571. doi: 10.18632/oncotarget.13771. PubMed |
| Proteome-Scale Investigation of Protein Allosteric Regulation Perturbed by Somatic Mutations in 7,000 Cancer Genomes. Shen Q, Cheng F, Song H, Lu W, Zhao J, An X, Liu M, Chen G, Zhao Z, Zhang J. Am J Hum Genet. 2017 Jan 5;100(1):5-20. doi: 10.1016/j.ajhg.2016.09.020. Epub 2016 Dec 8. PubMed |
| Fyn kinase regulates translation in mammalian mitochondria. Koc EC, Miller-Lee JL, Koc H. Biochim Biophys Acta. 2017 Mar;1861(3):533-540. doi: 10.1016/j.bbagen.2016.12.004. Epub 2016 Dec 7. PubMed |
| Different Use of Cell Surface Glycosaminoglycans As Adherence Receptors to Corneal Cells by Gram Positive and Gram Negative Pathogens. Garcia B, Merayo-Lloves J, Rodriguez D, Alcalde I, Garcia-Suarez O, Alfonso JF, Baamonde B, Fernandez-Vega A, Vazquez F, Quiros LM. Front Cell Infect Microbiol. 2016 Nov 30;6:173. eCollection 2016. PubMed |
| CD63 regulates Epstein-Barr virus LMP1 exosomal packaging, enhancement of vesicle production, and non-canonical NF-kappaB signaling. Hurwitz SN, Nkosi D, Conlon MM, York SB, Liu X, Tremblay DC, Meckes DG Jr. J Virol. 2016 Dec 14. pii: JVI.02251-16. PubMed |
| RIP3 antagonizes a TSC2-mediated pro-survival pathway in glioblastoma cell death. Fettweis G, Di Valentin E, L'homme L, Lassence C, Dequiedt F, Fillet M, Coupienne I, Piette J. Biochim Biophys Acta. 2016 Oct 27. pii: S0167-4889(16)30276-2. doi: 10.1016/j.bbamcr.2016.10.014. PubMed |
Perturb-Seq: Dissecting Molecular Circuits with Scalable Single-Cell RNA Profiling of Pooled Genetic Screens.
Dixit A, Parnas O, Li B, Chen J, Fulco CP, Jerby-Arnon L, Marjanovic ND, Dionne D, Burks T, Raychowdhury R, Adamson B, Norman TM, Lander ES, Weissman JS, Friedman N, Regev A.
Cell. 2016 Dec 15;167(7):1853-1866.e17. doi: 10.1016/j.cell.2016.11.038.
PubMed
Associated Plasmids |
In vivo high-throughput profiling of CRISPR-Cpf1 activity.
Kim HK, Song M, Lee J, Menon AV, Jung S, Kang YM, Choi JW, Woo E, Koh HC, Nam JW, Kim H.
Nat Methods. 2016 Dec 19. doi: 10.1038/nmeth.4104.
PubMed
Associated Plasmids |
| Nuclear Localization of Integrin Cytoplasmic Associated Protein-1 Influences beta1 Integrin Activation and Recruits Krev/ Interaction Trapped-1 to the Nucleus. Draheim KM, Huet-Calderwood C, Simon B, Calderwood DA. J Biol Chem. 2016 Dec 21. pii: jbc.M116.762393. doi: 10.1074/jbc.M116.762393. PubMed |
| Metabolic Characterization of Intact Cells Reveals Intracellular Amyloid Beta but Not Its Precursor Protein to Reduce Mitochondrial Respiration. Schaefer PM, von Einem B, Walther P, Calzia E, von Arnim CA. PLoS One. 2016 Dec 22;11(12):e0168157. doi: 10.1371/journal.pone.0168157. eCollection 2016. PubMed |
| Zika virus infection induces mitosis abnormalities and apoptotic cell death of human neural progenitor cells. Souza BS, Sampaio GL, Pereira CS, Campos GS, Sardi SI, Freitas LA, Figueira CP, Paredes BD, Nonaka CK, Azevedo CM, Rocha VP, Bandeira AC, Mendez-Otero R, Dos Santos RR, Soares MB. Sci Rep. 2016 Dec 23;6:39775. doi: 10.1038/srep39775. PubMed |
| Prohibitin 2 Is an Inner Mitochondrial Membrane Mitophagy Receptor. Wei Y, Chiang WC, Sumpter R Jr, Mishra P, Levine B. Cell. 2017 Jan 12;168(1-2):224-238.e10. doi: 10.1016/j.cell.2016.11.042. Epub 2016 Dec 22. PubMed |
| Protein disulfide isomerase externalization in endothelial cells follows classical and unconventional routes. Araujo TL, Zeidler JD, Oliveira PV, Dias MH, Armelin HA, Laurindo FR. Free Radic Biol Med. 2016 Dec 27;103:199-208. doi: 10.1016/j.freeradbiomed.2016.12.021. PubMed |
| Proteins that interact with calgranulin B in the human colon cancer cell line HCT-116. Myung JK, Yeo SG, Kim KH, Baek KS, Shin D, Kim JH, Cho JY, Yoo BC. Oncotarget. 2017 Jan 24;8(4):6819-6832. doi: 10.18632/oncotarget.14301. PubMed |
| Nipbl Interacts with Zfp609 and the Integrator Complex to Regulate Cortical Neuron Migration. van den Berg DL, Azzarelli R, Oishi K, Martynoga B, Urban N, Dekkers DH, Demmers JA, Guillemot F. Neuron. 2016 Dec 20. pii: S0896-6273(16)30915-1. doi: 10.1016/j.neuron.2016.11.047. PubMed |
| Rational Design of Selective Allosteric Inhibitors of PHGDH and Serine Synthesis with Anti-tumor Activity. Wang Q, Liberti MV, Liu P, Deng X, Liu Y, Locasale JW, Lai L. Cell Chem Biol. 2016 Dec 20. pii: S2451-9456(16)30436-6. doi: 10.1016/j.chembiol.2016.11.013. PubMed |
| A screen for Fli-1 transcriptional modulators identifies PKC agonists that induce erythroid to megakaryocytic differentiation and suppress leukemogenesis. Liu T, Yao Y, Zhang G, Wang Y, Deng B, Song J, Li X, Han F, Xiao X, Yang J, Xia L, Li YJ, Plachynta M, Zhang M, Yan C, Mu S, Luo H, Zacksenhaus E, Hao X, Ben-David Y. Oncotarget. 2017 Mar 7;8(10):16728-16743. doi: 10.18632/oncotarget.14377. PubMed |
| Reprogramming Mouse Embryonic Fibroblasts with Transcription Factors to Induce a Hemogenic Program. Daniel MG, Pereira CF, Bernitz JM, Lemischka IR, Moore K. J Vis Exp. 2016 Dec 16;(118). doi: 10.3791/54372. PubMed |
| Annexin A8 promotes VEGF-A driven endothelial cell sprouting. Heitzig N, Brinkmann BF, Koerdt SN, Rosso G, Shahin V, Rescher U. Cell Adh Migr. 2017 Jan 6:1-13. doi: 10.1080/19336918.2016.1264559. PubMed |
| Characterisation of early changes in ovine CLN5 and CLN6 Batten disease neural cultures for the rapid screening of therapeutics. Best HL, Neverman NJ, Wicky HE, Mitchell NL, Leitch B, Hughes SM. Neurobiol Dis. 2017 Jan 5;100:62-74. doi: 10.1016/j.nbd.2017.01.001. PubMed |
| Oxidized nucleotide insertion by pol beta confounds ligation during base excision repair. Caglayan M, Horton JK, Dai DP, Stefanick DF, Wilson SH. Nat Commun. 2017 Jan 9;8:14045. doi: 10.1038/ncomms14045. PubMed |
| APC/C Dysfunction Limits Excessive Cancer Chromosomal Instability. Sansregret L, Patterson JO, Dewhurst S, Lopez-Garcia C, Koch A, McGranahan N, Chao WC, Barry DJ, Rowan A, Instrell R, Horswell S, Way M, Howell M, Singleton MR, Medema RH, Nurse P, Petronczki M, Swanton C. Cancer Discov. 2017 Jan 9. doi: 10.1158/2159-8290.CD-16-0645. PubMed |
| Translation from unconventional 5' start sites drives tumour initiation. Sendoel A, Dunn JG, Rodriguez EH, Naik S, Gomez NC, Hurwitz B, Levorse J, Dill BD, Schramek D, Molina H, Weissman JS, Fuchs E. Nature. 2017 Jan 26;541(7638):494-499. doi: 10.1038/nature21036. Epub 2017 Jan 11. PubMed |
| Alternative lengthening of telomeres can be maintained by preferential elongation of lagging strands. Min J, Wright WE, Shay JW. Nucleic Acids Res. 2017 Mar 17;45(5):2615-2628. doi: 10.1093/nar/gkw1295. PubMed |
| The E3 ubiquitin ligase NEDD4 is an LC3-interactive protein and regulates autophagy. Sun A, Wei J, Childress C, Shaw JH 4th, Peng K, Shao G, Yang W, Lin Q. Autophagy. 2017 Mar 4;13(3):522-537. doi: 10.1080/15548627.2016.1268301. Epub 2017 Jan 13. PubMed |
| Glioblastoma Cancer Stem Cells Evade Innate Immune Suppression of Self-Renewal through Reduced TLR4 Expression. Alvarado AG, Thiagarajan PS, Mulkearns-Hubert EE, Silver DJ, Hale JS, Alban TJ, Turaga SM, Jarrar A, Reizes O, Longworth MS, Vogelbaum MA, Lathia JD. Cell Stem Cell. 2017 Apr 6;20(4):450-461.e4. doi: 10.1016/j.stem.2016.12.001. Epub 2017 Jan 12. PubMed |
| Systematic evaluation of markers used for the identification of human induced pluripotent stem cells. Bharathan SP, Manian KV, Aalam SM, Palani D, Deshpande PA, Pratheesh MD, Srivastava A, Velayudhan SR. Biol Open. 2017 Jan 15;6(1):100-108. doi: 10.1242/bio.022111. PubMed |
| Dopamine promotes NMDA receptor hypofunction in the retina through D1 receptor-mediated Csk activation, Src inhibition and decrease of GluN2B phosphorylation. Socodato R, Santiago FN, Portugal CC, Domith I, Encarnacao TG, Loiola EC, Ventura AL, Cossenza M, Relvas JB, Castro NG, Paes-de-Carvalho R. Sci Rep. 2017 Jan 18;7:40912. doi: 10.1038/srep40912. PubMed |
| TRIM8 regulates stemness in glioblastoma through PIAS3-STAT3. Zhang C, Mukherjee S, Tucker-Burden C, Ross JL, Chau MJ, Kong J, Brat DJ. Mol Oncol. 2017 Mar;11(3):280-294. doi: 10.1002/1878-0261.12034. Epub 2017 Feb 15. PubMed |
| Psoriasin has divergent effects on the innate immune responses of murine glial cells. Jansen S, Kress E, Fragoulis A, Wruck CJ, Wolf R, Grotzinger J, Michalek M, Pufe T, Tauber SC, Brandenburg LO. J Neurochem. 2017 Apr;141(1):86-99. doi: 10.1111/jnc.13959. Epub 2017 Feb 27. PubMed |
An Argonaute phosphorylation cycle promotes microRNA-mediated silencing.
Golden RJ, Chen B, Li T, Braun J, Manjunath H, Chen X, Wu J, Schmid V, Chang TC, Kopp F, Ramirez-Martinez A, Tagliabracci VS, Chen ZJ, Xie Y, Mendell JT.
Nature. 2017 Feb 9;542(7640):197-202. doi: 10.1038/nature21025. Epub 2017 Jan 23.
PubMed
Associated Plasmids |
| Creation of Novel Protein Variants with CRISPR/Cas9-Mediated Mutagenesis: Turning a Screening By-Product into a Discovery Tool. Donovan KF, Hegde M, Sullender M, Vaimberg EW, Johannessen CM, Root DE, Doench JG. PLoS One. 2017 Jan 24;12(1):e0170445. doi: 10.1371/journal.pone.0170445. eCollection 2017. PubMed |
| Nectin-like 4 Complexes with Choline Transporter-like Protein-1 and Regulates Schwann Cell Choline Homeostasis and Lipid Biogenesis in Vitro. Heffernan C, Jain MR, Liu T, Kim H, Barretto K, Li H, Maurel P. J Biol Chem. 2017 Mar 17;292(11):4484-4498. doi: 10.1074/jbc.M116.747816. Epub 2017 Jan 24. PubMed |
| Physiologic and genetic evidence links hemopexin to triglycerides in mice and humans. Lawson HA, Zayed M, Wayhart JP, Fabbrini E, Love-Gregory L, Klein S, Semenkovich CF. Int J Obes (Lond). 2017 Apr;41(4):631-638. doi: 10.1038/ijo.2017.19. Epub 2017 Jan 25. PubMed |
| Mutations in tropomyosin 4 underlie a rare form of human macrothrombocytopenia. Pleines I, Woods J, Chappaz S, Kew V, Foad N, Ballester-Beltran J, Aurbach K, Lincetto C, Lane RM, Schevzov G, Alexander WS, Hilton DJ, Astle WJ, Downes K, Nurden P, Westbury SK, Mumford AD, Obaji SG, Collins PW, Delerue F, Ittner LM, Bryce NS, Holliday M, Lucas CA, Hardeman EC, Ouwehand WH, Gunning PW, Turro E, Tijssen MR, Kile BT. J Clin Invest. 2017 Mar 1;127(3):814-829. doi: 10.1172/JCI86154. Epub 2017 Jan 30. PubMed |
| Mouse Stbd1 is N-myristoylated and affects ER-mitochondria association and mitochondrial morphology. Demetriadou A, Morales-Sanfrutos J, Nearchou M, Baba O, Kyriacou K, Tate EW, Drousiotou A, Petrou PP. J Cell Sci. 2017 Mar 1;130(5):903-915. doi: 10.1242/jcs.195263. Epub 2017 Jan 30. PubMed |
| Matrix-regulated integrin alphavbeta5 maintains alpha5beta1-dependent desmoplastic traits prognostic of neoplastic recurrence. Franco-Barraza J, Francescone R, Luong T, Shah N, Madhani R, Cukierman G, Dulaimi E, Devarajan K, Egleston BL, Nicolas E, Katherine Alpaugh R, Malik R, Uzzo RG, Hoffman JP, Golemis EA, Cukierman E. Elife. 2017 Jan 31;6. doi: 10.7554/eLife.20600. PubMed |
| Visualization of aging-associated chromatin alterations with an engineered TALE system. Ren R, Deng L, Xue Y, Suzuki K, Zhang W, Yu Y, Wu J, Sun L, Gong X, Luan H, Yang F, Ju Z, Ren X, Wang S, Tang H, Geng L, Zhang W, Li J, Qiao J, Xu T, Qu J, Liu GH. Cell Res. 2017 Apr;27(4):483-504. doi: 10.1038/cr.2017.18. Epub 2017 Jan 31. PubMed |
| Metalloprotease-disintegrin ADAM12 actively promotes the stem cell-like phenotype in claudin-low breast cancer. Duhachek-Muggy S, Qi Y, Wise R, Alyahya L, Li H, Hodge J, Zolkiewska A. Mol Cancer. 2017 Feb 1;16(1):32. doi: 10.1186/s12943-017-0599-6. PubMed |
| Genome Editing Reveals Glioblastoma Addiction to MicroRNA-10b. El Fatimy R, Subramanian S, Uhlmann EJ, Krichevsky AM. Mol Ther. 2017 Feb 1;25(2):368-378. doi: 10.1016/j.ymthe.2016.11.004. PubMed |
Dnmt3a restrains mast cell inflammatory responses.
Leoni C, Montagner S, Rinaldi A, Bertoni F, Polletti S, Balestrieri C, Monticelli S.
Proc Natl Acad Sci U S A. 2017 Feb 6. pii: 201616420. doi: 10.1073/pnas.1616420114.
PubMed
Associated Plasmids |
| Epigenetic regulation of HDAC1 SUMOylation as an endogenous neuroprotection against Abeta toxicity in a mouse model of Alzheimer's disease. Tao CC, Hsu WL, Ma YL, Cheng SJ, Lee EH. Cell Death Differ. 2017 Apr;24(4):597-614. doi: 10.1038/cdd.2016.161. Epub 2017 Feb 10. PubMed |
| Diet-induced obesity links to ER positive breast cancer progression via LPA/PKD-1-CD36 signaling-mediated microvascular remodeling. Dong L, Yuan Y, Opansky C, Chen Y, Aguilera-Barrantes I, Wu S, Yuan R, Cao Q, Cheng YC, Sahoo D, Silverstein RL, Ren B. Oncotarget. 2017 Apr 4;8(14):22550-22562. doi: 10.18632/oncotarget.15123. PubMed |
| E3 ubiquitin ligase Pirh2 enhances tumorigenic properties of human non-small cell lung carcinoma cells. Daks A, Petukhov A, Fedorova O, Shuvalov O, Merkulov V, Vasileva E, Antonov A, Barlev NA. Genes Cancer. 2016 Nov;7(11-12):383-393. doi: 10.18632/genesandcancer.123. PubMed |
| Method for Dual Viral Vector Mediated CRISPR-Cas9 Gene Disruption in Primary Human Endothelial Cells. Gong H, Liu M, Klomp J, Merrill BJ, Rehman J, Malik AB. Sci Rep. 2017 Feb 15;7:42127. doi: 10.1038/srep42127. PubMed |
| Jerantinine A induces tumor-specific cell death through modulation of splicing factor 3b subunit 1 (SF3B1). Chung FF, Tan PF, Raja VJ, Tan BS, Lim KH, Kam TS, Hii LW, Tan SH, See SJ, Tan YF, Wong LZ, Yam WK, Mai CW, Bradshaw TD, Leong CO. Sci Rep. 2017 Feb 15;7:42504. doi: 10.1038/srep42504. PubMed |
| HOXC8 regulates self-renewal, differentiation and transformation of breast cancer stem cells. Shah M, Cardenas R, Wang B, Persson J, Mongan NP, Grabowska A, Allegrucci C. Mol Cancer. 2017 Feb 16;16(1):38. doi: 10.1186/s12943-017-0605-z. PubMed |
| Restriction of Human Cytomegalovirus Replication by ISG15, a Host Effector Regulated by cGAS-STING Double-Stranded-DNA Sensing. Bianco C, Mohr I. J Virol. 2017 Apr 13;91(9). pii: JVI.02483-16. doi: 10.1128/JVI.02483-16. Print 2017 May 1. PubMed |
| Expression level is a key determinant of E2F1-mediated cell fate. Shats I, Deng M, Davidovich A, Zhang C, Kwon JS, Manandhar D, Gordan R, Yao G, You L. Cell Death Differ. 2017 Apr;24(4):626-637. doi: 10.1038/cdd.2017.12. Epub 2017 Feb 17. PubMed |
| The CRISPR/Cas9 system efficiently reverts the tumorigenic ability of BCR/ABL in vitro and in a xenograft model of chronic myeloid leukemia. Garcia-Tunon I, Hernandez-Sanchez M, Ordonez JL, Alonso-Perez V, Alamo-Quijada M, Benito R, Guerrero C, Hernandez-Rivas JM, Sanchez-Martin M. Oncotarget. 2017 Apr 18;8(16):26027-26040. doi: 10.18632/oncotarget.15215. PubMed |
| SoxC Transcription Factors Promote Contralateral Retinal Ganglion Cell Differentiation and Axon Guidance in the Mouse Visual System. Kuwajima T, Soares CA, Sitko AA, Lefebvre V, Mason C. Neuron. 2017 Mar 8;93(5):1110-1125.e5. doi: 10.1016/j.neuron.2017.01.029. Epub 2017 Feb 16. PubMed |
| Bassoon Controls Presynaptic Autophagy through Atg5. Okerlund ND, Schneider K, Leal-Ortiz S, Montenegro-Venegas C, Kim SA, Garner LC, Waites CL, Gundelfinger ED, Reimer RJ, Garner CC. Neuron. 2017 Feb 22;93(4):897-913.e7. doi: 10.1016/j.neuron.2017.01.026. PubMed |
| Critical threshold levels of DNA methyltransferase 1 are required to maintain DNA methylation across the genome in human cancer cells. Cai Y, Tsai HC, Yen RC, Zhang YW, Kong X, Wang W, Xia L, Baylin SB. Genome Res. 2017 Apr;27(4):533-544. doi: 10.1101/gr.208108.116. Epub 2017 Feb 23. PubMed |
| Hyperglycemia-Induced Changes in ZIP7 and ZnT7 Expression Cause Zn2+ Release From the Sarco(endo)plasmic Reticulum and Mediate ER Stress in the Heart. Tuncay E, Bitirim VC, Durak A, Carrat GRJ, Taylor KM, Rutter GA, Turan B. Diabetes. 2017 May;66(5):1346-1358. doi: 10.2337/db16-1099. Epub 2017 Feb 23. PubMed |
| Editing VEGFR2 Blocks VEGF-Induced Activation of Akt and Tube Formation. Huang X, Zhou G, Wu W, Ma G, D'Amore PA, Mukai S, Lei H. Invest Ophthalmol Vis Sci. 2017 Feb 1;58(2):1228-1236. doi: 10.1167/iovs.16-20537. PubMed |
| YOD1/TRAF6 association balances p62-dependent IL-1 signaling to NF-kappaB. Schimmack G, Schorpp K, Kutzner K, Gehring T, Brenke JK, Hadian K, Krappmann D. Elife. 2017 Feb 28;6. pii: e22416. doi: 10.7554/eLife.22416. PubMed |
| A Comprehensive TALEN-Based Knockout Library for Generating Human-Induced Pluripotent Stem Cell-Based Models for Cardiovascular Diseases. Karakikes I, Termglinchan V, Cepeda DA, Lee J, Diecke S, Hendel A, Itzhaki I, Ameen M, Shrestha R, Wu H, Ma N, Shao NY, Seeger T, Woo N, Wilson KD, Matsa E, Porteus MH, Sebastiano V, Wu JC. Circ Res. 2017 May 12;120(10):1561-1571. doi: 10.1161/CIRCRESAHA.116.309948. Epub 2017 Feb 28. PubMed |
Rapid and efficient generation of oligodendrocytes from human induced pluripotent stem cells using transcription factors.
Ehrlich M, Mozafari S, Glatza M, Starost L, Velychko S, Hallmann AL, Cui QL, Schambach A, Kim KP, Bachelin C, Marteyn A, Hargus G, Johnson RM, Antel J, Sterneckert J, Zaehres H, Scholer HR, Baron-Van Evercooren A, Kuhlmann T.
Proc Natl Acad Sci U S A. 2017 Mar 14;114(11):E2243-E2252. doi: 10.1073/pnas.1614412114. Epub 2017 Feb 28.
PubMed
Associated Plasmids |
| Regulatory Axis of miR-195/497 and HMGA1-Id3 Governs Muscle Cell Proliferation and Differentiation. Qiu H, Zhong J, Luo L, Tang Z, Liu N, Kang K, Li L, Gou D. Int J Biol Sci. 2017 Jan 15;13(2):157-166. doi: 10.7150/ijbs.17440. eCollection 2017. PubMed |
| Pseudohypoxia induced by miR-126 deactivation promotes migration and therapeutic resistance in renal cell carcinoma. Liu W, Chen H, Wong N, Haynes W, Baker CM, Wang X. Cancer Lett. 2017 May 28;394:65-75. doi: 10.1016/j.canlet.2017.02.025. Epub 2017 Feb 28. PubMed |
| Linking of mPGES-1 and iNOS activates stem-like phenotype in EGFR-driven epithelial tumor cells. Terzuoli E, Finetti F, Costanza F, Giachetti A, Ziche M, Donnini S. Nitric Oxide. 2017 Jun 1;66:17-29. doi: 10.1016/j.niox.2017.02.010. Epub 2017 Mar 1. PubMed |
| Reactive Oxygen Species-Mediated Loss of Synaptic Akt1 Signaling Leads to Deficient Activity-Dependent Protein Translation Early in Alzheimer's Disease. Ahmad F, Singh K, Das D, Gowaikar R, Shaw E, Ramachandran A, Rupanagudi KV, Kommaddi RP, Bennett DA, Ravindranath V. Antioxid Redox Signal. 2017 Apr 12. doi: 10.1089/ars.2016.6860. PubMed |
| Focal Adhesion Kinase as a Potential Target in AML and MDS. Carter BZ, Mak PY, Wang X, Yang H, Garcia-Manero G, Mak DH, Mu H, Ruvolo VR, Qiu Y, Coombes K, Zhang N, Ragon B, Weaver DT, Pachter JA, Kornblau S, Andreeff M. Mol Cancer Ther. 2017 Jun;16(6):1133-1144. doi: 10.1158/1535-7163.MCT-16-0719. Epub 2017 Mar 7. PubMed |
| Integrin-beta4 identifies cancer stem cell-enriched populations of partially mesenchymal carcinoma cells. Bierie B, Pierce SE, Kroeger C, Stover DG, Pattabiraman DR, Thiru P, Liu Donaher J, Reinhardt F, Chaffer CL, Keckesova Z, Weinberg RA. Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):E2337-E2346. doi: 10.1073/pnas.1618298114. Epub 2017 Mar 7. PubMed |
| The Novel Toll-Like Receptor 2 Agonist SUP3 Enhances Antigen Presentation and T Cell Activation by Dendritic Cells. Guo X, Wu N, Shang Y, Liu X, Wu T, Zhou Y, Liu X, Huang J, Liao X, Wu L. Front Immunol. 2017 Feb 21;8:158. doi: 10.3389/fimmu.2017.00158. eCollection 2017. PubMed |
| Reconstituting development of pancreatic intraepithelial neoplasia from primary human pancreas duct cells. Lee J, Snyder ER, Liu Y, Gu X, Wang J, Flowers BM, Kim YJ, Park S, Szot GL, Hruban RH, Longacre TA, Kim SK. Nat Commun. 2017 Mar 8;8:14686. doi: 10.1038/ncomms14686. PubMed |
DUX4-induced dsRNA and MYC mRNA stabilization activate apoptotic pathways in human cell models of facioscapulohumeral dystrophy.
Shadle SC, Zhong JW, Campbell AE, Conerly ML, Jagannathan S, Wong CJ, Morello TD, van der Maarel SM, Tapscott SJ.
PLoS Genet. 2017 Mar 8;13(3):e1006658. doi: 10.1371/journal.pgen.1006658. eCollection 2017 Mar.
PubMed
Associated Plasmids |
| GARLH Family Proteins Stabilize GABAA Receptors at Synapses. Yamasaki T, Hoyos-Ramirez E, Martenson JS, Morimoto-Tomita M, Tomita S. Neuron. 2017 Mar 8;93(5):1138-1152.e6. doi: 10.1016/j.neuron.2017.02.023. PubMed |
| CRISPR-Cas9 system-driven site-specific selection pressure on Herpes simplex virus genomes. Li Z, Bi Y, Xiao H, Sun L, Ren Y, Li Y, Chen C, Cun W. Virus Res. 2017 Mar 6. pii: S0168-1702(16)30694-3. doi: 10.1016/j.virusres.2017.03.010. PubMed |
| Depletion of oxaloacetate decarboxylase FAHD1 inhibits mitochondrial electron transport and induces cellular senescence in human endothelial cells. Petit M, Koziel R, Etemad S, Pircher H, Jansen-Durr P. Exp Gerontol. 2017 Jun;92:7-12. doi: 10.1016/j.exger.2017.03.004. Epub 2017 Mar 8. PubMed |
Optogenetic control with a photocleavable protein, PhoCl.
Zhang W, Lohman AW, Zhuravlova Y, Lu X, Wiens MD, Hoi H, Yaganoglu S, Mohr MA, Kitova EN, Klassen JS, Pantazis P, Thompson RJ, Campbell RE.
Nat Methods. 2017 Mar 13. doi: 10.1038/nmeth.4222.
PubMed
Associated Plasmids |
| PSMA redirects cell survival signaling from the MAPK to the PI3K-AKT pathways to promote the progression of prostate cancer. Caromile LA, Dortche K, Rahman MM, Grant CL, Stoddard C, Ferrer FA, Shapiro LH. Sci Signal. 2017 Mar 14;10(470). pii: 10/470/eaag3326. doi: 10.1126/scisignal.aag3326. PubMed |
| ORAI2 modulates store-operated calcium entry and T cell-mediated immunity. Vaeth M, Yang J, Yamashita M, Zee I, Eckstein M, Knosp C, Kaufmann U, Karoly Jani P, Lacruz RS, Flockerzi V, Kacskovics I, Prakriya M, Feske S. Nat Commun. 2017 Mar 15;8:14714. doi: 10.1038/ncomms14714. PubMed |
DND1 maintains germline stem cells via recruitment of the CCR4-NOT complex to target mRNAs.
Yamaji M, Jishage M, Meyer C, Suryawanshi H, Der E, Yamaji M, Garzia A, Morozov P, Manickavel S, McFarland HL, Roeder RG, Hafner M, Tuschl T.
Nature. 2017 Mar 23;543(7646):568-572. doi: 10.1038/nature21690. Epub 2017 Mar 15.
PubMed
Associated Plasmids |
| Quantifying 3D chemotaxis in microfluidic-based chips with step gradients of collagen hydrogel concentrations. Del Amo C, Borau C, Movilla N, Asin J, Garcia-Aznar JM. Integr Biol (Camb). 2017 Apr 18;9(4):339-349. doi: 10.1039/c7ib00022g. PubMed |
| Tumor Suppressor PTPRJ Is a Target of miR-155 in Colorectal Cancer. Zhang XF, Tu R, Li K, Ye P, Cui X. J Cell Biochem. 2017 Mar 18. doi: 10.1002/jcb.25995. PubMed |
| Silencing of the small GTPase DIRAS3 induces cellular senescence in human white adipose stromal/progenitor cells. Ejaz A, Mattesich M, Zwerschke W. Aging (Albany NY). 2017 Mar 17;9(3):860-879. doi: 10.18632/aging.101197. PubMed |
| Transcription factor NF-kappa B represses ANT1 transcription and leads to mitochondrial dysfunctions. Zhang C, Jiang H, Wang P, Liu H, Sun X. Sci Rep. 2017 Mar 20;7:44708. doi: 10.1038/srep44708. PubMed |
| Hepatocyte nuclear factor 1alpha downregulates HBV gene expression and replication by activating the NF-kappaB signaling pathway. Lin J, Gu C, Shen Z, Liu Y, Wang W, Tao S, Cui X, Liu J, Xie Y. PLoS One. 2017 Mar 20;12(3):e0174017. doi: 10.1371/journal.pone.0174017. eCollection 2017. PubMed |
| The H3K27 demethylase, Utx, regulates adipogenesis in a differentiation stage-dependent manner. Ota K, Tong KI, Goto K, Tomida S, Komuro A, Wang Z, Nishio K, Okada H. PLoS One. 2017 Mar 20;12(3):e0173713. doi: 10.1371/journal.pone.0173713. eCollection 2017. PubMed |
| Association of Cardiac Galectin-3 Expression, Myocarditis, and Fibrosis in Chronic Chagas Disease Cardiomyopathy. Souza BSF, Silva DN, Carvalho RH, Sampaio GLA, Paredes BD, Aragao Franca L, Azevedo CM, Vasconcelos JF, Meira CS, Neto PC, Macambira SG, da Silva KN, Allahdadi KJ, Tavora F, de Souza Neto JD, Dos Santos RR, Soares MBP. Am J Pathol. 2017 May;187(5):1134-1146. doi: 10.1016/j.ajpath.2017.01.016. Epub 2017 Mar 17. PubMed |
| Using Protein-Fragment Complementation Assays (PCA) and Peptide Arrays to Study Telomeric Protein-Protein Interactions. Ma W, Lee OH, Kim H, Songyang Z. Methods Mol Biol. 2017;1587:147-160. doi: 10.1007/978-1-4939-6892-3_15. PubMed |
| Bovine trophectoderm cells induced from bovine fibroblasts with induced pluripotent stem cell reprogramming factors. Talbot NC, Sparks WO, Phillips CE, Ealy AD, Powell AM, Caperna TJ, Garrett WM, Donovan DM, Blomberg LA. Mol Reprod Dev. 2017 Jun;84(6):468-485. doi: 10.1002/mrd.22797. Epub 2017 Apr 12. PubMed |
Genome-scale CRISPR-Cas9 knockout and transcriptional activation screening.
Joung J, Konermann S, Gootenberg JS, Abudayyeh OO, Platt RJ, Brigham MD, Sanjana NE, Zhang F.
Nat Protoc. 2017 Apr;12(4):828-863. doi: 10.1038/nprot.2017.016. Epub 2017 Mar 23.
PubMed
Associated Plasmids |
| Geometry-dependent functional changes in iPSC-derived cardiomyocytes probed by functional imaging and RNA sequencing. Werley CA, Chien MP, Gaublomme J, Shekhar K, Butty V, Yi BA, Kralj JM, Bloxham W, Boyer LA, Regev A, Cohen AE. PLoS One. 2017 Mar 23;12(3):e0172671. doi: 10.1371/journal.pone.0172671. eCollection 2017. PubMed |
| Requirement of cytosolic phospholipase A2 gamma in lipid droplet formation. Su X, Liu S, Zhang X, Lam SM, Hu X, Zhou Y, Chen J, Wang Y, Wu C, Shui G, Lu M, Pei R, Chen X. Biochim Biophys Acta. 2017 Jul;1862(7):692-705. doi: 10.1016/j.bbalip.2017.03.007. Epub 2017 Mar 21. PubMed |
A DNA-Based T Cell Receptor Reveals a Role for Receptor Clustering in Ligand Discrimination.
Taylor MJ, Husain K, Gartner ZJ, Mayor S, Vale RD.
Cell. 2017 Mar 23;169(1):108-119.e20. doi: 10.1016/j.cell.2017.03.006.
PubMed
Associated Plasmids |
| Polo-like kinase 1 expression is suppressed by CCAAT/enhancer-binding protein alpha to mediate colon carcinoma cell differentiation and apoptosis. Dasgupta N, Thakur BK, Ta A, Das S, Banik G, Das S. Biochim Biophys Acta. 2017 Jul;1861(7):1777-1787. doi: 10.1016/j.bbagen.2017.03.015. Epub 2017 Mar 21. PubMed |
| Sedentary lifestyle related exosomal release of Hotair from gluteal-femoral fat promotes intestinal cell proliferation. Lu X, Bai D, Liu X, Zhou C, Yang G. Sci Rep. 2017 Mar 31;7:45648. doi: 10.1038/srep45648. PubMed |
| CRISPR-Cas9 Mediated Gene-Silencing of the Mutant Huntingtin Gene in an In Vitro Model of Huntington's Disease. Kolli N, Lu M, Maiti P, Rossignol J, Dunbar GL. Int J Mol Sci. 2017 Apr 2;18(4). pii: E754. doi: 10.3390/ijms18040754. PubMed |
CRISPR-Cas9 epigenome editing enables high-throughput screening for functional regulatory elements in the human genome.
Klann TS, Black JB, Chellappan M, Safi A, Song L, Hilton IB, Crawford GE, Reddy TE, Gersbach CA.
Nat Biotechnol. 2017 Apr 3. doi: 10.1038/nbt.3853.
PubMed
Associated Plasmids |
| Dissection of ubiquitinated protein degradation by basal autophagy. Takayama K, Matsuura A, Itakura E. FEBS Lett. 2017 May;591(9):1199-1211. doi: 10.1002/1873-3468.12641. Epub 2017 Apr 18. PubMed |
| FKBP65-dependent peptidyl-prolyl isomerase activity potentiates the lysyl hydroxylase 2-driven collagen cross-link switch. Chen Y, Terajima M, Banerjee P, Guo H, Liu X, Yu J, Yamauchi M, Kurie JM. Sci Rep. 2017 Apr 5;7:46021. doi: 10.1038/srep46021. PubMed |
| Targeting ABL-IRE1alpha Signaling Spares ER-Stressed Pancreatic beta Cells to Reverse Autoimmune Diabetes. Morita S, Villalta SA, Feldman HC, Register AC, Rosenthal W, Hoffmann-Petersen IT, Mehdizadeh M, Ghosh R, Wang L, Colon-Negron K, Meza-Acevedo R, Backes BJ, Maly DJ, Bluestone JA, Papa FR. Cell Metab. 2017 Apr 4;25(4):883-897.e8. doi: 10.1016/j.cmet.2017.03.018. PubMed |
| Pyroptosis and Apoptosis Pathways Engage in Bidirectional Crosstalk in Monocytes and Macrophages. Taabazuing CY, Okondo MC, Bachovchin DA. Cell Chem Biol. 2017 Apr 20;24(4):507-514.e4. doi: 10.1016/j.chembiol.2017.03.009. Epub 2017 Apr 6. PubMed |
| Crystal structure of Zen4 in the apo state reveals a missing conformation of kinesin. Guan R, Zhang L, Su QP, Mickolajczyk KJ, Chen GY, Hancock WO, Sun Y, Zhao Y, Chen Z. Nat Commun. 2017 Apr 10;8:14951. doi: 10.1038/ncomms14951. PubMed |
| Regulation of spindle integrity and mitotic fidelity by BCCIP. Huhn SC, Liu J, Ye C, Lu H, Jiang X, Feng X, Ganesan S, White E, Shen Z. Oncogene. 2017 Aug 17;36(33):4750-4766. doi: 10.1038/onc.2017.92. Epub 2017 Apr 10. PubMed |
| GP73 represses host innate immune response to promote virus replication by facilitating MAVS and TRAF6 degradation. Zhang X, Zhu C, Wang T, Jiang H, Ren Y, Zhang Q, Wu K, Liu F, Liu Y, Wu J. PLoS Pathog. 2017 Apr 10;13(4):e1006321. doi: 10.1371/journal.ppat.1006321. eCollection 2017 Apr. PubMed |
| Generation of an induced pluripotent stem cell line that mimics the disease phenotypes from a patient with Fanconi anemia by conditional complementation. Bharathan SP, Nandy K, Palani D, Janet A NB, Natarajan K, George B, Srivastava A, Velayudhan SR. Stem Cell Res. 2017 Apr;20:54-57. doi: 10.1016/j.scr.2017.02.006. Epub 2017 Feb 22. PubMed |
| Hoxa9 and Meis1 Cooperatively Induce Addiction to Syk Signaling by Suppressing miR-146a in Acute Myeloid Leukemia. Mohr S, Doebele C, Comoglio F, Berg T, Beck J, Bohnenberger H, Alexe G, Corso J, Strobel P, Wachter A, Beissbarth T, Schnutgen F, Cremer A, Haetscher N, Gollner S, Rouhi A, Palmqvist L, Rieger MA, Schroeder T, Bonig H, Muller-Tidow C, Kuchenbauer F, Schutz E, Green AR, Urlaub H, Stegmaier K, Humphries RK, Serve H, Oellerich T. Cancer Cell. 2017 Apr 10;31(4):549-562.e11. doi: 10.1016/j.ccell.2017.03.001. PubMed |
| Nucleotide-binding oligomerization domain (NOD) signaling defects and cell death susceptibility cannot be uncoupled in X-linked inhibitor of apoptosis (XIAP)-driven inflammatory disease. Chirieleison SM, Marsh RA, Kumar P, Rathkey JK, Dubyak GR, Abbott DW. J Biol Chem. 2017 Jun 9;292(23):9666-9679. doi: 10.1074/jbc.M117.781500. Epub 2017 Apr 12. PubMed |
| Epithelial-Mesenchymal Micro-niches Govern Stem Cell Lineage Choices. Yang H, Adam RC, Ge Y, Hua ZL, Fuchs E. Cell. 2017 Apr 20;169(3):483-496.e13. doi: 10.1016/j.cell.2017.03.038. Epub 2017 Apr 13. PubMed |
| A tiling-deletion-based genetic screen for cis-regulatory element identification in mammalian cells. Diao Y, Fang R, Li B, Meng Z, Yu J, Qiu Y, Lin KC, Huang H, Liu T, Marina RJ, Jung I, Shen Y, Guan KL, Ren B. Nat Methods. 2017 Jun;14(6):629-635. doi: 10.1038/nmeth.4264. Epub 2017 Apr 17. PubMed |
Nitric oxide-regulated proteolysis of human CYP2B6 via the ubiquitin-proteasome system.
Lee CM, Tripathi S, Morgan ET.
Free Radic Biol Med. 2017 Jul;108:478-486. doi: 10.1016/j.freeradbiomed.2017.04.015. Epub 2017 Apr 17.
PubMed
Associated Plasmids |
| Bone-in-culture array as a platform to model early-stage bone metastases and discover anti-metastasis therapies. Wang H, Tian L, Goldstein A, Liu J, Lo HC, Sheng K, Welte T, Wong STC, Gugala Z, Stossi F, Zong C, Li Z, Mancini MA, Zhang XH. Nat Commun. 2017 Apr 21;8:15045. doi: 10.1038/ncomms15045. PubMed |
| Ezrin activation by LOK phosphorylation involves a PIP2-dependent wedge mechanism. Pelaseyed T, Viswanatha R, Sauvanet C, Filter JJ, Goldberg ML, Bretscher A. Elife. 2017 Apr 21;6. pii: e22759. doi: 10.7554/eLife.22759. PubMed |
| High-content analysis screening for cell cycle regulators using arrayed synthetic crRNA libraries. Strezoska Z, Perkett MR, Chou ET, Maksimova E, Anderson EM, McClelland S, Kelley ML, Vermeulen A, Smith AVB. J Biotechnol. 2017 Jun 10;251:189-200. doi: 10.1016/j.jbiotec.2017.04.017. Epub 2017 Apr 23. PubMed |
Methyl-CpG binding domain protein 1 regulates localization and activity of Tet1 in a CXXC3 domain-dependent manner.
Zhang P, Rausch C, Hastert FD, Boneva B, Filatova A, Patil SJ, Nuber UA, Gao Y, Zhao X, Cardoso MC.
Nucleic Acids Res. 2017 Apr 25. doi: 10.1093/nar/gkx281.
PubMed
Associated Plasmids |
| TIR-domain-containing adapter-inducing interferon-beta (TRIF) forms filamentous structures, whose pro-apoptotic signalling is terminated by autophagy. Gentle IE, McHenry KT, Weber A, Metz A, Kretz O, Porter D, Hacker G. FEBS J. 2017 Jul;284(13):1987-2003. doi: 10.1111/febs.14091. Epub 2017 May 19. PubMed |
| MARCKS phosphorylation is modulated by a peptide mimetic of MARCKS effector domain leading to increased radiation sensitivity in lung cancer cell lines. Rohrbach TD, Jones RB, Hicks PH, Weaver AN, Cooper TS, Eustace NJ, Yang ES, Jarboe JS, Anderson JC, Willey CD. Oncol Lett. 2017 Mar;13(3):1216-1222. doi: 10.3892/ol.2016.5550. Epub 2016 Dec 29. PubMed |
| Age-dependent functional crosstalk between cardiac fibroblasts and cardiomyocytes in a 3D engineered cardiac tissue. Li Y, Asfour H, Bursac N. Acta Biomater. 2017 Jun;55:120-130. doi: 10.1016/j.actbio.2017.04.027. Epub 2017 Apr 25. PubMed |
| PARP1 restricts Epstein Barr Virus lytic reactivation by binding the BZLF1 promoter. Lupey-Green LN, Moquin SA, Martin KA, McDevitt SM, Hulse M, Caruso LB, Pomerantz RT, Miranda JL, Tempera I. Virology. 2017 Jul;507:220-230. doi: 10.1016/j.virol.2017.04.006. Epub 2017 Apr 26. PubMed |
| JNK-associated scattered growth of YD-10B oral squamous carcinoma cells while maintaining the epithelial phenotype. Lee G, Kim HM. Biochem Biophys Res Commun. 2017 Jun 10;487(4):862-867. doi: 10.1016/j.bbrc.2017.04.142. Epub 2017 Apr 27. PubMed |
| Quiescence of human muscle stem cells is favored by culture on natural biopolymeric films. Monge C, DiStasio N, Rossi T, Sebastien M, Sakai H, Kalman B, Boudou T, Tajbakhsh S, Marty I, Bigot A, Mouly V, Picart C. Stem Cell Res Ther. 2017 May 2;8(1):104. doi: 10.1186/s13287-017-0556-8. PubMed |
| A Novel Agonist of the TRIF Pathway Induces a Cellular State Refractory to Replication of Zika, Chikungunya, and Dengue Viruses. Pryke KM, Abraham J, Sali TM, Gall BJ, Archer I, Liu A, Bambina S, Baird J, Gough M, Chakhtoura M, Haddad EK, Kirby IT, Nilsen A, Streblow DN, Hirsch AJ, Smith JL, DeFilippis VR. MBio. 2017 May 2;8(3). pii: e00452-17. doi: 10.1128/mBio.00452-17. PubMed |
| Aberrant caveolin-1-mediated Smad signaling and proliferation identified by analysis of adenine 474 deletion mutation (c.474delA) in patient fibroblasts: a new perspective on the mechanism of pulmonary hypertension. Marsboom G, Chen Z, Yuan Y, Zhang Y, Tiruppathi C, Loyd JE, Austin ED, Machado RF, Minshall RD, Rehman J, Malik AB. Mol Biol Cell. 2017 May 1;28(9):1177-1185. doi: 10.1091/mbc.E16-11-0790. PubMed |
| Primary cilia control the maturation of tubular lumen in renal collecting duct epithelium. Ernandez T, Komarynets O, Chassot A, Sougoumarin S, Soulie P, Wang Y, Montesano R, Feraille E. Am J Physiol Cell Physiol. 2017 Jul 1;313(1):C94-C107. doi: 10.1152/ajpcell.00290.2016. Epub 2017 May 3. PubMed |
| Releasing Syntaphilin Removes Stressed Mitochondria from Axons Independent of Mitophagy under Pathophysiological Conditions. Lin MY, Cheng XT, Tammineni P, Xie Y, Zhou B, Cai Q, Sheng ZH. Neuron. 2017 May 3;94(3):595-610.e6. doi: 10.1016/j.neuron.2017.04.004. PubMed |
| CHD1 regulates cell fate determination by activation of differentiation-induced genes. Baumgart SJ, Najafova Z, Hossan T, Xie W, Nagarajan S, Kari V, Ditzel N, Kassem M, Johnsen SA. Nucleic Acids Res. 2017 May 5. doi: 10.1093/nar/gkx377. PubMed |
| Linear ubiquitination of cytosolic Salmonella Typhimurium activates NF-kappaB and restricts bacterial proliferation. van Wijk SJL, Fricke F, Herhaus L, Gupta J, Hotte K, Pampaloni F, Grumati P, Kaulich M, Sou YS, Komatsu M, Greten FR, Fulda S, Heilemann M, Dikic I. Nat Microbiol. 2017 May 8;2:17066. doi: 10.1038/nmicrobiol.2017.66. PubMed |
| Electrophysiological Properties and Viability of Neonatal Rat Ventricular Myocyte Cultures with Inducible ChR2 Expression. Li Q, Ni RR, Hong H, Goh KY, Rossi M, Fast VG, Zhou L. Sci Rep. 2017 May 8;7(1):1531. doi: 10.1038/s41598-017-01723-2. PubMed |
| CHD4 Has Oncogenic Functions in Initiating and Maintaining Epigenetic Suppression of Multiple Tumor Suppressor Genes. Xia L, Huang W, Bellani M, Seidman MM, Wu K, Fan D, Nie Y, Cai Y, Zhang YW, Yu LR, Li H, Zahnow CA, Xie W, Chiu Yen RW, Rassool FV, Baylin SB. Cancer Cell. 2017 May 8;31(5):653-668.e7. doi: 10.1016/j.ccell.2017.04.005. PubMed |
| Cap-binding protein 4EHP effects translation silencing by microRNAs. Chapat C, Jafarnejad SM, Matta-Camacho E, Hesketh GG, Gelbart IA, Attig J, Gkogkas CG, Alain T, Stern-Ginossar N, Fabian MR, Gingras AC, Duchaine TF, Sonenberg N. Proc Natl Acad Sci U S A. 2017 May 23;114(21):5425-5430. doi: 10.1073/pnas.1701488114. Epub 2017 May 9. PubMed |
| Protein Phosphatase 2A (PP2A) Regulates EG5 to Control Mitotic Progression. Liu Y, Zhang Z, Liang H, Zhao X, Liang L, Wang G, Yang J, Jin Y, McNutt MA, Yin Y. Sci Rep. 2017 May 9;7(1):1630. doi: 10.1038/s41598-017-01915-w. PubMed |
| Sensing of HIV-1 Entry Triggers a Type I Interferon Response in Human Primary Macrophages. Decalf J, Desdouits M, Rodrigues V, Gobert FX, Gentili M, Marques-Ladeira S, Chamontin C, Mougel M, Cunha de Alencar B, Benaroch P. J Virol. 2017 Jul 12;91(15). pii: e00147-17. doi: 10.1128/JVI.00147-17. Print 2017 Aug 1. PubMed |
| Deletion of the Vaccinia Virus I2 Protein Interrupts Virion Morphogenesis, Leading to Retention of the Scaffold Protein and Mislocalization of Membrane-Associated Entry Proteins. Hyun SI, Weisberg A, Moss B. J Virol. 2017 Jul 12;91(15). pii: e00558-17. doi: 10.1128/JVI.00558-17. Print 2017 Aug 1. PubMed |
| CRISPR/Cas9 Screens Reveal Epstein-Barr Virus-Transformed B Cell Host Dependency Factors. Ma Y, Walsh MJ, Bernhardt K, Ashbaugh CW, Trudeau SJ, Ashbaugh IY, Jiang S, Jiang C, Zhao B, Root DE, Doench JG, Gewurz BE. Cell Host Microbe. 2017 May 10;21(5):580-591.e7. doi: 10.1016/j.chom.2017.04.005. PubMed |
| PHD3 is a transcriptional coactivator of HIF-1alpha in nucleus pulposus cells independent of the PKM2-JMJD5 axis. Schoepflin ZR, Silagi ES, Shapiro IM, Risbud MV. FASEB J. 2017 May 11. pii: fj.201601291R. doi: 10.1096/fj.201601291R. PubMed |
| Integrase-Deficient Lentiviral Vector as an All-in-One Platform for Highly Efficient CRISPR/Cas9-Mediated Gene Editing. Ortinski PI, O'Donovan B, Dong X, Kantor B. Mol Ther Methods Clin Dev. 2017 Apr 19;5:153-164. doi: 10.1016/j.omtm.2017.04.002. eCollection 2017 Jun 16. PubMed |
| Structure based discovery of clomifene as a potent inhibitor of cancer-associated mutant IDH1. Zheng M, Sun W, Gao S, Luan S, Li D, Chen R, Zhang Q, Chen L, Huang J, Li H. Oncotarget. 2017 Jul 4;8(27):44255-44265. doi: 10.18632/oncotarget.17464. PubMed |
| A clinical drug library screen identifies clobetasol propionate as an NRF2 inhibitor with potential therapeutic efficacy in KEAP1 mutant lung cancer. Choi EJ, Jung BJ, Lee SH, Yoo HS, Shin EA, Ko HJ, Chang S, Kim SY, Jeon SM. Oncogene. 2017 Sep 14;36(37):5285-5295. doi: 10.1038/onc.2017.153. Epub 2017 May 15. PubMed |
| Role of NF-E2 related factor 2 (Nrf2) on chemotherapy resistance in acute myeloid leukemia (AML) and the effect of pharmacological inhibition of Nrf2. Karathedath S, Rajamani BM, Musheer Aalam SM, Abraham A, Varatharajan S, Krishnamurthy P, Mathews V, Velayudhan SR, Balasubramanian P. PLoS One. 2017 May 15;12(5):e0177227. doi: 10.1371/journal.pone.0177227. eCollection 2017. PubMed |
| A dual phenotype of MDA-MB-468 cancer cells reveals mutual regulation of tensin3 and adhesion plasticity. Vess A, Blache U, Leitner L, Kurz ARM, Ehrenpfordt A, Sixt M, Posern G. J Cell Sci. 2017 Jul 1;130(13):2172-2184. doi: 10.1242/jcs.200899. Epub 2017 May 17. PubMed |
| E2F1 inhibits circulating cholesterol clearance by regulating Pcsk9 expression in the liver. Lai Q, Giralt A, Le May C, Zhang L, Cariou B, Denechaud PD, Fajas L. JCI Insight. 2017 May 18;2(10). pii: 89729. doi: 10.1172/jci.insight.89729. PubMed |
| Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells. Wei HH, Liu Y, Wang Y, Lu Q, Yang X, Li J, Wang Z. J Vis Exp. 2017 Apr 26;(122). doi: 10.3791/54967. PubMed |
| Generation of chromosomal translocations that lead to conditional fusion protein expression using CRISPR-Cas9 and homology-directed repair. Vanoli F, Jasin M. Methods. 2017 May 15;121-122:138-145. doi: 10.1016/j.ymeth.2017.05.006. Epub 2017 May 15. PubMed |
Homology-mediated end joining-based targeted integration using CRISPR/Cas9.
Yao X, Wang X, Hu X, Liu Z, Liu J, Zhou H, Shen X, Wei Y, Huang Z, Ying W, Wang Y, Nie YH, Zhang CC, Li S, Cheng L, Wang Q, Wu Y, Huang P, Sun Q, Shi L, Yang H.
Cell Res. 2017 May 19. doi: 10.1038/cr.2017.76.
PubMed
Associated Plasmids |
| Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function. Sakamaki JI, Wilkinson S, Hahn M, Tasdemir N, O'Prey J, Clark W, Hedley A, Nixon C, Long JS, New M, Van Acker T, Tooze SA, Lowe SW, Dikic I, Ryan KM. Mol Cell. 2017 May 18;66(4):517-532.e9. doi: 10.1016/j.molcel.2017.04.027. PubMed |
| Shedding of host autophagic proteins from the parasitophorous vacuolar membrane of Plasmodium berghei. Agop-Nersesian C, De Niz M, Niklaus L, Prado M, Eickel N, Heussler VT. Sci Rep. 2017 May 19;7(1):2191. doi: 10.1038/s41598-017-02156-7. PubMed |
| The N-terminus of the prion protein is a toxic effector regulated by the C-terminus. Wu B, McDonald AJ, Markham K, Rich CB, McHugh KP, Tatzelt J, Colby DW, Millhauser GL, Harris DA. Elife. 2017 May 20;6. pii: e23473. doi: 10.7554/eLife.23473. PubMed |
| CRISPR/Cas9 - Mediated Precise Targeted Integration In Vivo Using a Double Cut Donor with Short Homology Arms. Yao X, Wang X, Liu J, Hu X, Shi L, Shen X, Ying W, Sun X, Wang X, Huang P, Yang H. EBioMedicine. 2017 Jun;20:19-26. doi: 10.1016/j.ebiom.2017.05.015. Epub 2017 May 11. PubMed |
| A novel isoform of TET1 that lacks a CXXC domain is overexpressed in cancer. Good CR, Madzo J, Patel B, Maegawa S, Engel N, Jelinek J, Issa JJ. Nucleic Acids Res. 2017 May 22. doi: 10.1093/nar/gkx435. PubMed |
| Polylactide- and polycaprolactone-based substrates enhance angiogenic potential of human umbilical cord-derived mesenchymal stem cells in vitro - implications for cardiovascular repair. Sekula M, Domalik-Pyzik P, Morawska-Chochol A, Bobis-Wozowicz S, Karnas E, Noga S, Boruczkowski D, Adamiak M, Madeja Z, Chlopek J, Zuba-Surma EK. Mater Sci Eng C Mater Biol Appl. 2017 Aug 1;77:521-533. doi: 10.1016/j.msec.2017.03.281. Epub 2017 Mar 30. PubMed |
| cGAS is essential for cellular senescence. Yang H, Wang H, Ren J, Chen Q, Chen ZJ. Proc Natl Acad Sci U S A. 2017 Jun 6;114(23):E4612-E4620. doi: 10.1073/pnas.1705499114. Epub 2017 May 22. PubMed |
| The ubiquitin ligase STUB1 regulates stability and activity of RUNX1 and RUNX1-RUNX1T1. Yonezawa T, Takahashi H, Shikata S, Liu X, Tamura M, Asada S, Fukushima T, Fukuyama T, Tanaka Y, Sawasaki T, Kitamura T, Goyama S. J Biol Chem. 2017 Jul 28;292(30):12528-12541. doi: 10.1074/jbc.M117.785675. Epub 2017 May 23. PubMed |
| CD146 (MCAM) in human cs-DLK1-/cs-CD34+ adipose stromal/progenitor cells. Horl S, Ejaz A, Ernst S, Mattesich M, Kaiser A, Jenewein B, Zwierzina ME, Hammerle S, Miggitsch C, Mitterberger-Vogt MC, Krautgasser C, Pierer G, Zwerschke W. Stem Cell Res. 2017 Jul;22:1-12. doi: 10.1016/j.scr.2017.05.004. Epub 2017 May 17. PubMed |
| The immunosuppressive cytokine interleukin-4 increases the clonogenic potential of prostate stem-like cells by activation of STAT6 signalling. Nappo G, Handle F, Santer FR, McNeill RV, Seed RI, Collins AT, Morrone G, Culig Z, Maitland NJ, Erb HHH. Oncogenesis. 2017 May 29;6(5):e342. doi: 10.1038/oncsis.2017.23. PubMed |
CRISPR-Cas9-induced t(11;19)/MLL-ENL translocations initiate leukemia in human hematopoietic progenitor cells in vivo.
Reimer J, Knoess S, Labuhn M, Charpentier EM, Gohring G, Schlegelberger B, Klusmann JH, Heckl D.
Haematologica. 2017 Jun 1. pii: haematol.2017.164046. doi: 10.3324/haematol.2017.164046.
PubMed
Associated Plasmids |
| Synchronized HIV assembly by tunable PIP2 changes reveals PIP2 requirement for stable Gag anchoring. Mucksch F, Laketa V, Muller B, Schultz C, Krausslich HG. Elife. 2017 Jun 2;6. pii: e25287. doi: 10.7554/eLife.25287. PubMed |
| Hepatitis B virus X protein promotes CREB-mediated activation of miR-3188 and Notch signaling in hepatocellular carcinoma. Zhou SJ, Deng YL, Liang HF, Jaoude JC, Liu FY. Cell Death Differ. 2017 Sep;24(9):1577-1587. doi: 10.1038/cdd.2017.87. Epub 2017 Jun 2. PubMed |
| IRF2-INPP4B axis participates in the development of acute myeloid leukemia by regulating cell growth and survival. Zhang F, Zhu J, Li J, Zhu F, Zhang P. Gene. 2017 Sep 5;627:9-14. doi: 10.1016/j.gene.2017.06.001. Epub 2017 Jun 2. PubMed |
| The PYRIN domain-only protein POP2 inhibits inflammasome priming and activation. Ratsimandresy RA, Chu LH, Khare S, de Almeida L, Gangopadhyay A, Indramohan M, Misharin AV, Greaves DR, Perlman H, Dorfleutner A, Stehlik C. Nat Commun. 2017 Jun 5;8:15556. doi: 10.1038/ncomms15556. PubMed |
| Mice deficient of Myc super-enhancer region reveal differential control mechanism between normal and pathological growth. Dave K, Sur I, Yan J, Zhang J, Kaasinen E, Zhong F, Blaas L, Li X, Kharazi S, Gustafsson C, De Paepe A, Mansson R, Taipale J. Elife. 2017 Jun 6;6. pii: e23382. doi: 10.7554/eLife.23382. PubMed |
| Effect of tryptase inhibition on joint inflammation: a pharmacological and lentivirus-mediated gene transfer study. Denadai-Souza A, Ribeiro CM, Rolland C, Thouard A, Deraison C, Scavone C, Gonzalez-Dunia D, Vergnolle N, Avellar MCW. Arthritis Res Ther. 2017 Jun 6;19(1):124. doi: 10.1186/s13075-017-1326-9. PubMed |
| Tightly controlled MRTF-A activity regulates epithelial differentiation during formation of mammary acini. Seifert A, Posern G. Breast Cancer Res. 2017 Jun 7;19(1):68. doi: 10.1186/s13058-017-0860-3. PubMed |
| Linaclotide activates guanylate cyclase-C/cGMP/protein kinase-II-dependent trafficking of CFTR in the intestine. Ahsan MK, Tchernychev B, Kessler MM, Solinga RM, Arthur D, Linde CI, Silos-Santiago I, Hannig G, Ameen NA. Physiol Rep. 2017 Jun;5(11). pii: 5/11/e13299. doi: 10.14814/phy2.13299. PubMed |
| The metalloproteinase ADAM8 promotes leukocyte recruitment in vitro and in acute lung inflammation. Dreymueller D, Pruessmeyer J, Schumacher J, Fellendorf S, Hess FM, Seifert A, Babendreyer A, Bartsch JW, Ludwig A. Am J Physiol Lung Cell Mol Physiol. 2017 Jun 8:ajplung.00444.2016. doi: 10.1152/ajplung.00444.2016. PubMed |
| Integrin alpha7 Is a Functional Marker and Potential Therapeutic Target in Glioblastoma. Haas TL, Sciuto MR, Brunetto L, Valvo C, Signore M, Fiori ME, di Martino S, Giannetti S, Morgante L, Boe A, Patrizii M, Warnken U, Schnolzer M, Ciolfi A, Di Stefano C, Biffoni M, Ricci-Vitiani L, Pallini R, De Maria R. Cell Stem Cell. 2017 Jul 6;21(1):35-50.e9. doi: 10.1016/j.stem.2017.04.009. Epub 2017 Jun 9. PubMed |
Construction and Screening of a Lentiviral Secretome Library.
Liu T, Jia P, Ma H, Reed SA, Luo X, Larman HB, Schultz PG.
Cell Chem Biol. 2017 Jun 22;24(6):767-771.e3. doi: 10.1016/j.chembiol.2017.05.017. Epub 2017 Jun 9.
PubMed
Associated Plasmids |
| Antigen Presentation by Individually Transferred HLA Class I Genes in HLA-A, HLA-B, HLA-C Null Human Cell Line Generated Using the Multiplex CRISPR-Cas9 System. Hong CH, Sohn HJ, Lee HJ, Cho HI, Kim TG. J Immunother. 2017 Jul/Aug;40(6):201-210. doi: 10.1097/CJI.0000000000000176. PubMed |
| Reduction of infection by inhibiting mTOR pathway is associated with reversed repression of type I interferon by porcine reproductive and respiratory syndrome virus. Liu Q, Miller LC, Blecha F, Sang Y. J Gen Virol. 2017 Jun;98(6):1316-1328. doi: 10.1099/jgv.0.000802. Epub 2017 Jun 14. PubMed |
| Defects in autophagosome-lysosome fusion underlie Vici syndrome, a neurodevelopmental disorder with multisystem involvement. Hori I, Otomo T, Nakashima M, Miya F, Negishi Y, Shiraishi H, Nonoda Y, Magara S, Tohyama J, Okamoto N, Kumagai T, Shimoda K, Yukitake Y, Kajikawa D, Morio T, Hattori A, Nakagawa M, Ando N, Nishino I, Kato M, Tsunoda T, Saitsu H, Kanemura Y, Yamasaki M, Kosaki K, Matsumoto N, Yoshimori T, Saitoh S. Sci Rep. 2017 Jun 14;7(1):3552. doi: 10.1038/s41598-017-02840-8. PubMed |
| BAIAP3, a C2 domain-containing Munc13 protein, controls the fate of dense-core vesicles in neuroendocrine cells. Zhang X, Jiang S, Mitok KA, Li L, Attie AD, Martin TFJ. J Cell Biol. 2017 Jul 3;216(7):2151-2166. doi: 10.1083/jcb.201702099. Epub 2017 Jun 16. PubMed |
| Autophagy impairment mediated by S-nitrosation of ATG4B leads to neurotoxicity in response to hyperglycemia. Li Y, Zhang Y, Wang L, Wang P, Xue Y, Li X, Qiao X, Zhang X, Xu T, Liu G, Li P, Chen C. Autophagy. 2017 Jul 3;13(7):1145-1160. doi: 10.1080/15548627.2017.1320467. PubMed |
| A novel fluorescent probe reveals starvation controls the commitment of amyloid precursor protein to the lysosome. Hein LK, Apaja PM, Hattersley K, Grose RH, Xie J, Proud CG, Sargeant TJ. Biochim Biophys Acta. 2017 Jun 19;1864(10):1554-1565. doi: 10.1016/j.bbamcr.2017.06.011. PubMed |
| Sam68 Allows Selective Targeting of Human Cancer Stem Cells. Benoit YD, Mitchell RR, Risueno RM, Orlando L, Tanasijevic B, Boyd AL, Aslostovar L, Salci KR, Shapovalova Z, Russell J, Eguchi M, Golubeva D, Graham M, Xenocostas A, Trus MR, Foley R, Leber B, Collins TJ, Bhatia M. Cell Chem Biol. 2017 Jul 20;24(7):833-844.e9. doi: 10.1016/j.chembiol.2017.05.026. Epub 2017 Jun 22. PubMed |
| Targeting MCL-1 sensitizes human esophageal squamous cell carcinoma cells to cisplatin-induced apoptosis. Yu X, Li W, Xia Z, Xie L, Ma X, Liang Q, Liu L, Wang J, Zhou X, Yang Y, Liu H. BMC Cancer. 2017 Jun 28;17(1):449. doi: 10.1186/s12885-017-3442-y. PubMed |
The RNA Surveillance Factor UPF1 Represses Myogenesis via Its E3 Ubiquitin Ligase Activity.
Feng Q, Jagannathan S, Bradley RK.
Mol Cell. 2017 Jul 20;67(2):239-251.e6. doi: 10.1016/j.molcel.2017.05.034. Epub 2017 Jun 29.
PubMed
Associated Plasmids |
| TTC19 Plays a Husbandry Role on UQCRFS1 Turnover in the Biogenesis of Mitochondrial Respiratory Complex III. Bottani E, Cerutti R, Harbour ME, Ravaglia S, Dogan SA, Giordano C, Fearnley IM, D'Amati G, Viscomi C, Fernandez-Vizarra E, Zeviani M. Mol Cell. 2017 Jul 6;67(1):96-105.e4. doi: 10.1016/j.molcel.2017.06.001. Epub 2017 Jun 29. PubMed |
| Lack of evidence for involvement of TonEBP and hyperosmotic stimulus in induction of autophagy in the nucleus pulposus. Liu C, Choi H, Johnson ZI, Tian J, Shapiro IM, Risbud MV. Sci Rep. 2017 Jul 3;7(1):4543. doi: 10.1038/s41598-017-04876-2. PubMed |
| In-Cell Western Assays to Evaluate Hantaan Virus Replication as a Novel Approach to Screen Antiviral Molecules and Detect Neutralizing Antibody Titers. Ma HW, Ye W, Chen HS, Nie TJ, Cheng LF, Zhang L, Han PJ, Wu XA, Xu ZK, Lei YF, Zhang FL. Front Cell Infect Microbiol. 2017 Jun 20;7:269. doi: 10.3389/fcimb.2017.00269. eCollection 2017. PubMed |
| Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway. Viswanathan VS, Ryan MJ, Dhruv HD, Gill S, Eichhoff OM, Seashore-Ludlow B, Kaffenberger SD, Eaton JK, Shimada K, Aguirre AJ, Viswanathan SR, Chattopadhyay S, Tamayo P, Yang WS, Rees MG, Chen S, Boskovic ZV, Javaid S, Huang C, Wu X, Tseng YY, Roider EM, Gao D, Cleary JM, Wolpin BM, Mesirov JP, Haber DA, Engelman JA, Boehm JS, Kotz JD, Hon CS, Chen Y, Hahn WC, Levesque MP, Doench JG, Berens ME, Shamji AF, Clemons PA, Stockwell BR, Schreiber SL. Nature. 2017 Jul 27;547(7664):453-457. doi: 10.1038/nature23007. Epub 2017 Jul 5. PubMed |
| Recombinant elastin based nanoparticles for targeted gene therapy. Monfort DA, Koria P. Gene Ther. 2017 Jul 5. doi: 10.1038/gt.2017.54. PubMed |
| Coculture of mesenchymal stem cells and endothelial cells enhances host tissue integration and epidermis maturation through AKT activation in gelatin methacryloyl hydrogel-based skin model. Zhang X, Li J, Ye P, Gao G, Hubbell K, Cui X. Acta Biomater. 2017 Jul 3. pii: S1742-7061(17)30429-4. doi: 10.1016/j.actbio.2017.07.001. PubMed |
| The E3 ubiquitin ligase and RNA-binding protein ZNF598 orchestrates ribosome quality control of premature polyadenylated mRNAs. Garzia A, Jafarnejad SM, Meyer C, Chapat C, Gogakos T, Morozov P, Amiri M, Shapiro M, Molina H, Tuschl T, Sonenberg N. Nat Commun. 2017 Jul 7;8:16056. doi: 10.1038/ncomms16056. PubMed |
| Increased levels of Gab1 and Gab2 adaptor proteins skew IL-4 signaling toward M2 macrophage-driven pulmonary fibrosis in mice. Guo X, Li T, Xu Y, Xu X, Zhu Z, Zhang Y, Xu J, Xu K, Cheng H, Zhang X, Ke Y. J Biol Chem. 2017 Jul 7. pii: jbc.M117.802066. doi: 10.1074/jbc.M117.802066. PubMed |
| Condensin II is anchored by TFIIIC and H3K4me3 in the mammalian genome and supports the expression of active dense gene clusters. Yuen KC, Slaughter BD, Gerton JL. Sci Adv. 2017 Jun 21;3(6):e1700191. doi: 10.1126/sciadv.1700191. eCollection 2017 Jun. PubMed |
| Nrf2 deficiency exacerbates ochratoxin A-induced toxicity in vitro and in vivo. Loboda A, Stachurska A, Sobczak M, Podkalicka P, Mucha O, Jozkowicz A, Dulak J. Toxicology. 2017 Aug 15;389:42-52. doi: 10.1016/j.tox.2017.07.004. Epub 2017 Jul 12. PubMed |
| VE-Cadherin Phosphorylation Regulates Endothelial Fluid Shear Stress Responses through the Polarity Protein LGN. Conway DE, Coon BG, Budatha M, Arsenovic PT, Orsenigo F, Wessel F, Zhang J, Zhuang Z, Dejana E, Vestweber D, Schwartz MA. Curr Biol. 2017 Jul 24;27(14):2219-2225.e5. doi: 10.1016/j.cub.2017.06.020. Epub 2017 Jul 14. PubMed |
| Quantifying spontaneous metastasis in a syngeneic mouse melanoma model using real time PCR. Deng W, McLaughlin SL, Klinke DJ. Analyst. 2017 Aug 7;142(16):2945-2953. doi: 10.1039/c7an00623c. PubMed |
| Single-Cell Imaging of ERK Signaling Using Fluorescent Biosensors. Pargett M, Gillies TE, Teragawa CK, Sparta B, Albeck JG. Methods Mol Biol. 2017;1636:35-59. doi: 10.1007/978-1-4939-7154-1_3. PubMed |
| EINCR1 is an EGF inducible lincRNA overexpressed in lung adenocarcinomas. Nowicki-Osuch K, Li Y, Challinor M, Gerrard DT, Hanley NA, Sharrocks AD. PLoS One. 2017 Jul 21;12(7):e0181902. doi: 10.1371/journal.pone.0181902. eCollection 2017. PubMed |
| Co-transplantation of mesenchymal and neural stem cells and overexpressing stromal-derived factor-1 for treating spinal cord injury. Stewart AN, Kendziorski G, Deak ZM, Brown DJ, Fini MN, Copely KL, Rossignol J, Dunbar GL. Brain Res. 2017 Oct 1;1672:91-105. doi: 10.1016/j.brainres.2017.07.005. Epub 2017 Jul 20. PubMed |
| Stimulus-evoked ERK-dependent phosphorylation of activity-regulated cytoskeleton-associated protein (Arc) regulates its neuronal subcellular localization. Nikolaienko O, Eriksen MS, Patil S, Bito H, Bramham CR. Neuroscience. 2017 Sep 30;360:68-80. doi: 10.1016/j.neuroscience.2017.07.026. Epub 2017 Jul 21. PubMed |
| Optimization of proximity ligation assay (PLA) for detection of protein interactions and fusion proteins in non-adherent cells: application to pre-B lymphocytes. Debaize L, Jakobczyk H, Rio AG, Gandemer V, Troadec MB. Mol Cytogenet. 2017 Jul 20;10:27. doi: 10.1186/s13039-017-0328-2. eCollection 2017. PubMed |
| Actomyosin drives cancer cell nuclear dysmorphia and threatens genome stability. Takaki T, Montagner M, Serres MP, Le Berre M, Russell M, Collinson L, Szuhai K, Howell M, Boulton SJ, Sahai E, Petronczki M. Nat Commun. 2017 Jul 24;8:16013. doi: 10.1038/ncomms16013. PubMed |
| NFATc2 enhances tumor-initiating phenotypes through the NFATc2/SOX2/ALDH axis in lung adenocarcinoma. Xiao ZJ, Liu J, Wang SQ, Zhu Y, Gao XY, Tin VP, Qin J, Wang JW, Wong MP. Elife. 2017 Jul 24;6. doi: 10.7554/eLife.26733. PubMed |
| Circadian repressors CRY1 and CRY2 broadly interact with nuclear receptors and modulate transcriptional activity. Kriebs A, Jordan SD, Soto E, Henriksson E, Sandate CR, Vaughan ME, Chan AB, Duglan D, Papp SJ, Huber AL, Afetian ME, Yu RT, Zhao X, Downes M, Evans RM, Lamia KA. Proc Natl Acad Sci U S A. 2017 Aug 15;114(33):8776-8781. doi: 10.1073/pnas.1704955114. Epub 2017 Jul 27. PubMed |
| Defining a Cancer Dependency Map. Tsherniak A, Vazquez F, Montgomery PG, Weir BA, Kryukov G, Cowley GS, Gill S, Harrington WF, Pantel S, Krill-Burger JM, Meyers RM, Ali L, Goodale A, Lee Y, Jiang G, Hsiao J, Gerath WFJ, Howell S, Merkel E, Ghandi M, Garraway LA, Root DE, Golub TR, Boehm JS, Hahn WC. Cell. 2017 Jul 27;170(3):564-576.e16. doi: 10.1016/j.cell.2017.06.010. PubMed |
| FiloQuant reveals increased filopodia density during breast cancer progression. Jacquemet G, Paatero I, Carisey AF, Padzik A, Orange JS, Hamidi H, Ivaska J. J Cell Biol. 2017 Oct 2;216(10):3387-3403. doi: 10.1083/jcb.201704045. Epub 2017 Aug 1. PubMed |
| Connexin 43 is required for the maintenance of mitochondrial integrity in brown adipose tissue. Kim SN, Kwon HJ, Im SW, Son YH, Akindehin S, Jung YS, Lee SJ, Rhyu IJ, Kim IY, Seong JK, Lee J, Yoo HC, Granneman JG, Lee YH. Sci Rep. 2017 Aug 2;7(1):7159. doi: 10.1038/s41598-017-07658-y. PubMed |
| An unbiased in vivo functional genomics screening approach in mice identifies novel tumor cell-based regulators of immune rejection. Shuptrine CW, Ajina R, Fertig EJ, Jablonski SA, Kim Lyerly H, Hartman ZC, Weiner LM. Cancer Immunol Immunother. 2017 Dec;66(12):1529-1544. doi: 10.1007/s00262-017-2047-2. Epub 2017 Aug 2. PubMed |
| Aneuploid Cell Survival Relies upon Sphingolipid Homeostasis. Tang YC, Yuwen H, Wang K, Bruno PM, Bullock K, Deik A, Santaguida S, Trakala M, Pfau SJ, Zhong N, Huang T, Wang L, Clish CB, Hemann MT, Amon A. Cancer Res. 2017 Oct 1;77(19):5272-5286. doi: 10.1158/0008-5472.CAN-17-0049. Epub 2017 Aug 3. PubMed |
| Genome-scale activation screen identifies a lncRNA locus regulating a gene neighbourhood. Joung J, Engreitz JM, Konermann S, Abudayyeh OO, Verdine VK, Aguet F, Gootenberg JS, Sanjana NE, Wright JB, Fulco CP, Tseng YY, Yoon CH, Boehm JS, Lander ES, Zhang F. Nature. 2017 Aug 11. doi: 10.1038/nature23451. PubMed |
| The Transcription Factor 7-Like 2-Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1 Alpha Axis Connects Mitochondrial Biogenesis and Metabolic Shift with Stem Cell Commitment to Hepatic Differentiation. Wanet A, Caruso M, Domelevo Entfellner JB, Najar M, Fattaccioli A, Demazy C, Evraerts J, El-Kehdy H, Pourcher G, Sokal E, Arnould T, Tiffin N, Najimi M, Renard P. Stem Cells. 2017 Oct;35(10):2184-2197. doi: 10.1002/stem.2688. Epub 2017 Aug 27. PubMed |
| PDI is an essential redox-sensitive activator of PERK during the unfolded protein response (UPR). Kranz P, Neumann F, Wolf A, Classen F, Pompsch M, Ocklenburg T, Baumann J, Janke K, Baumann M, Goepelt K, Riffkin H, Metzen E, Brockmeier U. Cell Death Dis. 2017 Aug 10;8(8):e2986. doi: 10.1038/cddis.2017.369. PubMed |
| Flow induced adherens junction remodeling driven by cytoskeletal forces. Verma D, Bajpai VK, Ye N, Maneshi MM, Jetta D, Andreadis ST, Sachs F, Hua SZ. Exp Cell Res. 2017 Oct 15;359(2):327-336. doi: 10.1016/j.yexcr.2017.08.009. Epub 2017 Aug 10. PubMed |
Elimination of Toxic Microsatellite Repeat Expansion RNA by RNA-Targeting Cas9.
Batra R, Nelles DA, Pirie E, Blue SM, Marina RJ, Wang H, Chaim IA, Thomas JD, Zhang N, Nguyen V, Aigner S, Markmiller S, Xia G, Corbett KD, Swanson MS, Yeo GW.
Cell. 2017 Aug 24;170(5):899-912.e10. doi: 10.1016/j.cell.2017.07.010. Epub 2017 Aug 10.
PubMed
Associated Plasmids |
A genetically encoded tool for manipulation of NADP+/NADPH in living cells.
Cracan V, Titov DV, Shen H, Grabarek Z, Mootha VK.
Nat Chem Biol. 2017 Aug 7. doi: 10.1038/nchembio.2454.
PubMed
Associated Plasmids |
A Becn1 mutation mediates hyperactive autophagic sequestration of amyloid oligomers and improved cognition in Alzheimer's disease.
Rocchi A, Yamamoto S, Ting T, Fan Y, Sadleir K, Wang Y, Zhang W, Huang S, Levine B, Vassar R, He C.
PLoS Genet. 2017 Aug 14;13(8):e1006962. doi: 10.1371/journal.pgen.1006962. eCollection 2017 Aug.
PubMed
Associated Plasmids |
| Transcription factor ZNF148 is a negative regulator of human muscle differentiation. Bakke J, Wright WC, Zamora AE, Ong SS, Wang YM, Hoyer JD, Brewer CT, Thomas PG, Chen T. Sci Rep. 2017 Aug 15;7(1):8138. doi: 10.1038/s41598-017-08267-5. PubMed |
| Stromal R-spondin orchestrates gastric epithelial stem cells and gland homeostasis. Sigal M, Logan CY, Kapalczynska M, Mollenkopf HJ, Berger H, Wiedenmann B, Nusse R, Amieva MR, Meyer TF. Nature. 2017 Aug 24;548(7668):451-455. doi: 10.1038/nature23642. Epub 2017 Aug 16. PubMed |
| CRISPR/Cas9 editing reveals novel mechanisms of clustered microRNA regulation and function. Lataniotis L, Albrecht A, Kok FO, Monfries CAL, Benedetti L, Lawson ND, Hughes SM, Steinhofel K, Mayr M, Zampetaki A. Sci Rep. 2017 Aug 17;7(1):8585. doi: 10.1038/s41598-017-09268-0. PubMed |
| A reversible phospho-switch mediated by ULK1 regulates the activity of autophagy protease ATG4B. Pengo N, Agrotis A, Prak K, Jones J, Ketteler R. Nat Commun. 2017 Aug 18;8(1):294. doi: 10.1038/s41467-017-00303-2. PubMed |
| Absolute measurement of gene transcripts with Selfie-digital PCR. Podlesniy P, Trullas R. Sci Rep. 2017 Aug 21;7(1):8328. doi: 10.1038/s41598-017-08270-w. PubMed |
| Nitric oxide stimulates cellular degradation of human CYP51A1, the highly conserved lanosterol 14alpha-demethylase. Park JW, Byrd A, Lee CM, Morgan ET. Biochem J. 2017 Sep 14;474(19):3241-3252. doi: 10.1042/BCJ20170459. PubMed |
| ZIC2 Is Essential for Maintenance of Latency and Is a Target of an Immediate Early Protein during Kaposi's Sarcoma-Associated Herpesvirus Lytic Reactivation. Lyu Y, Nakano K, Davis RR, Tepper CG, Campbell M, Izumiya Y. J Virol. 2017 Oct 13;91(21). pii: JVI.00980-17. doi: 10.1128/JVI.00980-17. Print 2017 Nov 1. PubMed |
| Smac mimetics and oncolytic viruses synergize in driving anticancer T-cell responses through complementary mechanisms. Kim DS, Dastidar H, Zhang C, Zemp FJ, Lau K, Ernst M, Rakic A, Sikdar S, Rajwani J, Naumenko V, Balce DR, Ewanchuk BW, Tailor P, Yates RM, Jenne C, Gafuik C, Mahoney DJ. Nat Commun. 2017 Aug 24;8(1):344. doi: 10.1038/s41467-017-00324-x. PubMed |
| TNF-alpha promotes nuclear enrichment of the transcription factor TonEBP/NFAT5 to selectively control inflammatory but not osmoregulatory responses in nucleus pulposus cells. Johnson ZI, Doolittle AC, Snuggs JW, Shapiro IM, Le Maitre CL, Risbud MV. J Biol Chem. 2017 Oct 20;292(42):17561-17575. doi: 10.1074/jbc.M117.790378. Epub 2017 Aug 25. PubMed |
| CDYL suppresses epileptogenesis in mice through repression of axonal Nav1.6 sodium channel expression. Liu Y, Lai S, Ma W, Ke W, Zhang C, Liu S, Zhang Y, Pei F, Li S, Yi M, Shu Y, Shang Y, Liang J, Huang Z. Nat Commun. 2017 Aug 25;8(1):355. doi: 10.1038/s41467-017-00368-z. PubMed |
| Mitochondrial permeabilization engages NF-kappaB-dependent anti-tumour activity under caspase deficiency. Giampazolias E, Zunino B, Dhayade S, Bock F, Cloix C, Cao K, Roca A, Lopez J, Ichim G, Proics E, Rubio-Patino C, Fort L, Yatim N, Woodham E, Orozco S, Taraborrelli L, Peltzer N, Lecis D, Machesky L, Walczak H, Albert ML, Milling S, Oberst A, Ricci JE, Ryan KM, Blyth K, Tait SWG. Nat Cell Biol. 2017 Sep;19(9):1116-1129. doi: 10.1038/ncb3596. Epub 2017 Aug 28. PubMed |
| ER stress and distinct outputs of the IRE1alpha RNase control proliferation and senescence in response to oncogenic Ras. Blazanin N, Son J, Craig-Lucas AB, John CL, Breech KJ, Podolsky MA, Glick AB. Proc Natl Acad Sci U S A. 2017 Sep 12;114(37):9900-9905. doi: 10.1073/pnas.1701757114. Epub 2017 Aug 28. PubMed |
| Prolonged exposure of mouse and human podocytes to insulin induces insulin resistance through lysosomal and proteasomal degradation of the insulin receptor. Lay AC, Hurcombe JA, Betin VMS, Barrington F, Rollason R, Ni L, Gillam L, Pearson GME, Ostergaard MV, Hamidi H, Lennon R, Welsh GI, Coward RJM. Diabetologia. 2017 Nov;60(11):2299-2311. doi: 10.1007/s00125-017-4394-0. Epub 2017 Aug 29. PubMed |
| Generation and characterization of transgenic mouse mesenchymal stem cell lines expressing hIGF-1 or hG-CSF. Goncalves GVM, Silva DN, Carvalho RH, Souza BSF, da Silva KN, Vasconcelos JF, Paredes BD, Nonaka CKV, Ribeiro-Dos-Santos R, Soares MBP. Cytotechnology. 2018 Apr;70(2):577-591. doi: 10.1007/s10616-017-0131-2. Epub 2017 Sep 2. PubMed |
| Global Inhibition with Specific Activation: How p53 and MYC Redistribute the Transcriptome in the DNA Double-Strand Break Response. Porter JR, Fisher BE, Baranello L, Liu JC, Kambach DM, Nie Z, Koh WS, Luo J, Stommel JM, Levens D, Batchelor E. Mol Cell. 2017 Sep 21;67(6):1013-1025.e9. doi: 10.1016/j.molcel.2017.07.028. Epub 2017 Aug 31. PubMed |
| Palmitoylation-dependent activation of MC1R prevents melanomagenesis. Chen S, Zhu B, Yin C, Liu W, Han C, Chen B, Liu T, Li X, Chen X, Li C, Hu L, Zhou J, Xu ZX, Gao X, Wu X, Goding CR, Cui R. Nature. 2017 Sep 21;549(7672):399-403. doi: 10.1038/nature23887. Epub 2017 Sep 6. PubMed |
| New in vivo avatars of diffuse intrinsic pontine gliomas (DIPG) from stereotactic biopsies performed at diagnosis. Plessier A, Le Dret L, Varlet P, Beccaria K, Lacombe J, Meriaux S, Geffroy F, Fiette L, Flamant P, Chretien F, Blauwblomme T, Puget S, Grill J, Debily MA, Castel D. Oncotarget. 2017 Feb 2;8(32):52543-52559. doi: 10.18632/oncotarget.15002. eCollection 2017 Aug 8. PubMed |
| Inhibition of DYRK1A disrupts neural lineage specificationin human pluripotent stem cells. Bellmaine SF, Ovchinnikov DA, Manallack DT, Cuddy CE, Elefanty AG, Stanley EG, Wolvetang EJ, Williams SJ, Pera M. Elife. 2017 Sep 8;6. pii: 24502. doi: 10.7554/eLife.24502. PubMed |
| MicroRNAs Induce a Permissive Chromatin Environment that Enables Neuronal Subtype-Specific Reprogramming of Adult Human Fibroblasts. Abernathy DG, Kim WK, McCoy MJ, Lake AM, Ouwenga R, Lee SW, Xing X, Li D, Lee HJ, Heuckeroth RO, Dougherty JD, Wang T, Yoo AS. Cell Stem Cell. 2017 Sep 7;21(3):332-348.e9. doi: 10.1016/j.stem.2017.08.002. PubMed |
| Modulation of hippocampal synapse maturation by activity-regulated E3 ligase via non-canonical pathway. Kumari P, Srinivasan B, Banerjee S. Neuroscience. 2017 Nov 19;364:226-241. doi: 10.1016/j.neuroscience.2017.08.057. Epub 2017 Sep 8. PubMed |
| Enhancing CD8(+) T Cell Fatty Acid Catabolism within a Metabolically Challenging Tumor Microenvironment Increases the Efficacy of Melanoma Immunotherapy. Zhang Y, Kurupati R, Liu L, Zhou XY, Zhang G, Hudaihed A, Filisio F, Giles-Davis W, Xu X, Karakousis GC, Schuchter LM, Xu W, Amaravadi R, Xiao M, Sadek N, Krepler C, Herlyn M, Freeman GJ, Rabinowitz JD, Ertl HCJ. Cancer Cell. 2017 Sep 11;32(3):377-391.e9. doi: 10.1016/j.ccell.2017.08.004. PubMed |
| KIF7 attenuates prostate tumor growth through LKB1-mediated AKT inhibition. Wong KY, Liu J, Chan KW. Oncotarget. 2017 Apr 26;8(33):54558-54571. doi: 10.18632/oncotarget.17421. eCollection 2017 Aug 15. PubMed |
| Exosome-mediated miR-146a transfer suppresses type I interferon response and facilitates EV71 infection. Fu Y, Zhang L, Zhang F, Tang T, Zhou Q, Feng C, Jin Y, Wu Z. PLoS Pathog. 2017 Sep 14;13(9):e1006611. doi: 10.1371/journal.ppat.1006611. eCollection 2017 Sep. PubMed |
| Loss of native alpha-synuclein multimerization by strategically mutating its amphipathic helix causes abnormal vesicle interactions in neuronal cells. Dettmer U, Ramalingam N, von Saucken VE, Kim TE, Newman AJ, Terry-Kantor E, Nuber S, Ericsson M, Fanning S, Bartels T, Lindquist S, Levy OA, Selkoe D. Hum Mol Genet. 2017 Sep 15;26(18):3466-3481. doi: 10.1093/hmg/ddx227. PubMed |
| SOX9 Regulates Cancer Stem-Like Properties and Metastatic Potential of Single-Walled Carbon Nanotube-Exposed Cells. Voronkova MA, Luanpitpong S, Rojanasakul LW, Castranova V, Dinu CZ, Riedel H, Rojanasakul Y. Sci Rep. 2017 Sep 14;7(1):11653. doi: 10.1038/s41598-017-12037-8. PubMed |
| Integrin alpha4 Overexpression on Rat Mesenchymal Stem Cells Enhances Transmigration and Reduces Cerebral Embolism After Intracarotid Injection. Cui LL, Nitzsche F, Pryazhnikov E, Tibeykina M, Tolppanen L, Rytkonen J, Huhtala T, Mu JW, Khiroug L, Boltze J, Jolkkonen J. Stroke. 2017 Oct;48(10):2895-2900. doi: 10.1161/STROKEAHA.117.017809. Epub 2017 Sep 15. PubMed |
| SmartFlares fail to reflect their target transcripts levels. Czarnek M, Bereta J. Sci Rep. 2017 Sep 15;7(1):11682. doi: 10.1038/s41598-017-11067-6. PubMed |
| Targeted Disruption of V600E-Mutant BRAF Gene by CRISPR-Cpf1. Yang M, Wei H, Wang Y, Deng J, Tang Y, Zhou L, Guo G, Tong A. Mol Ther Nucleic Acids. 2017 Sep 15;8:450-458. doi: 10.1016/j.omtn.2017.05.009. Epub 2017 May 17. PubMed |
| A Predictive Model for Selective Targeting of the Warburg Effect through GAPDH Inhibition with a Natural Product. Liberti MV, Dai Z, Wardell SE, Baccile JA, Liu X, Gao X, Baldi R, Mehrmohamadi M, Johnson MO, Madhukar NS, Shestov AA, Chio IIC, Elemento O, Rathmell JC, Schroeder FC, McDonnell DP, Locasale JW. Cell Metab. 2017 Oct 3;26(4):648-659.e8. doi: 10.1016/j.cmet.2017.08.017. Epub 2017 Sep 14. PubMed |
| p38(MAPK)/MK2-dependent phosphorylation controls cytotoxic RIPK1 signalling in inflammation and infection. Menon MB, Gropengiesser J, Fischer J, Novikova L, Deuretzbacher A, Lafera J, Schimmeck H, Czymmeck N, Ronkina N, Kotlyarov A, Aepfelbacher M, Gaestel M, Ruckdeschel K. Nat Cell Biol. 2017 Oct;19(10):1248-1259. doi: 10.1038/ncb3614. Epub 2017 Sep 18. PubMed |
| Novel ecto-tagged integrins reveal their trafficking in live cells. Huet-Calderwood C, Rivera-Molina F, Iwamoto DV, Kromann EB, Toomre D, Calderwood DA. Nat Commun. 2017 Sep 18;8(1):570. doi: 10.1038/s41467-017-00646-w. PubMed |
| Loss of RUNX1 is associated with aggressive lung adenocarcinomas. Ramsey J, Butnor K, Peng Z, Leclair T, van der Velden J, Stein G, Lian J, Kinsey CM. J Cell Physiol. 2018 Apr;233(4):3487-3497. doi: 10.1002/jcp.26201. Epub 2017 Nov 1. PubMed |
| RNA-Sequencing Analysis Reveals a Regulatory Role for Transcription Factor Fezf2 in the Mature Motor Cortex. Clare AJ, Wicky HE, Empson RM, Hughes SM. Front Mol Neurosci. 2017 Sep 7;10:283. doi: 10.3389/fnmol.2017.00283. eCollection 2017. PubMed |
| Huwe1 Regulates the Establishment and Maintenance of Spermatogonia by Suppressing DNA Damage Response. Fok KL, Bose R, Sheng K, Chang CW, Katz-Egorov M, Culty M, Su S, Yang M, Ruan YC, Chan HC, Iavarone A, Lasorella A, Cencic R, Pelletier J, Nagano M, Xu W, Wing SS. Endocrinology. 2017 Nov 1;158(11):4000-4016. doi: 10.1210/en.2017-00396. PubMed |
| Bicarbonate Recycling by HIF-1-Dependent Carbonic Anhydrase Isoforms 9 and 12 Is Critical in Maintaining Intracellular pH and Viability of Nucleus Pulposus Cells. Silagi ES, Schoepflin ZR, Seifert EL, Merceron C, Schipani E, Shapiro IM, Risbud MV. J Bone Miner Res. 2018 Feb;33(2):338-355. doi: 10.1002/jbmr.3293. Epub 2017 Oct 9. PubMed |
| Correction of beta-thalassemia mutant by base editor in human embryos. Liang P, Ding C, Sun H, Xie X, Xu Y, Zhang X, Sun Y, Xiong Y, Ma W, Liu Y, Wang Y, Fang J, Liu D, Songyang Z, Zhou C, Huang J. Protein Cell. 2017 Nov;8(11):811-822. doi: 10.1007/s13238-017-0475-6. Epub 2017 Sep 23. PubMed |
| Excitable Dynamics and Yap-Dependent Mechanical Cues Drive the Segmentation Clock. Hubaud A, Regev I, Mahadevan L, Pourquie O. Cell. 2017 Oct 19;171(3):668-682.e11. doi: 10.1016/j.cell.2017.08.043. Epub 2017 Sep 21. PubMed |
| NLRP3 Phosphorylation Is an Essential Priming Event for Inflammasome Activation. Song N, Liu ZS, Xue W, Bai ZF, Wang QY, Dai J, Liu X, Huang YJ, Cai H, Zhan XY, Han QY, Wang H, Chen Y, Li HY, Li AL, Zhang XM, Zhou T, Li T. Mol Cell. 2017 Oct 5;68(1):185-197.e6. doi: 10.1016/j.molcel.2017.08.017. Epub 2017 Sep 21. PubMed |
| Downregulated Adhesion-Associated microRNAs as Prognostic Predictors in Childhood Osteosarcoma. Delsin LEA, Roberto GM, Fedatto PF, Engel EE, Scrideli CA, Tone LG, Brassesco MS. Pathol Oncol Res. 2017 Sep 25. pii: 10.1007/s12253-017-0316-1. doi: 10.1007/s12253-017-0316-1. PubMed |
| Priming and Activation of Inflammasome by Canarypox Virus Vector ALVAC via the cGAS/IFI16-STING-Type I IFN Pathway and AIM2 Sensor. Liu F, Niu Q, Fan X, Liu C, Zhang J, Wei Z, Hou W, Kanneganti TD, Robb ML, Kim JH, Michael NL, Sun J, Soong L, Hu H. J Immunol. 2017 Nov 1;199(9):3293-3305. doi: 10.4049/jimmunol.1700698. Epub 2017 Sep 25. PubMed |
| Genome-Wide CRISPR Screen for Essential Cell Growth Mediators in Mutant KRAS Colorectal Cancers. Yau EH, Kummetha IR, Lichinchi G, Tang R, Zhang Y, Rana TM. Cancer Res. 2017 Nov 15;77(22):6330-6339. doi: 10.1158/0008-5472.CAN-17-2043. Epub 2017 Sep 27. PubMed |
| Transcriptional regulation of endothelial cell behavior during sprouting angiogenesis. Jeong HW, Hernandez-Rodriguez B, Kim J, Kim KP, Enriquez-Gasca R, Yoon J, Adams S, Scholer HR, Vaquerizas JM, Adams RH. Nat Commun. 2017 Sep 28;8(1):726. doi: 10.1038/s41467-017-00738-7. PubMed |
| MYC Controls Human Pluripotent Stem Cell Fate Decisions through Regulation of Metabolic Flux. Cliff TS, Wu T, Boward BR, Yin A, Yin H, Glushka JN, Prestegaard JH, Dalton S. Cell Stem Cell. 2017 Oct 5;21(4):502-516.e9. doi: 10.1016/j.stem.2017.08.018. Epub 2017 Sep 28. PubMed |
| Salt-inducible kinases (SIK) inhibition reduces RANKL-induced osteoclastogenesis. Lombardi MS, Gillieron C, Berkelaar M, Gabay C. PLoS One. 2017 Oct 3;12(10):e0185426. doi: 10.1371/journal.pone.0185426. eCollection 2017. PubMed |
| Dopamine cross-reacts with adrenoreceptors in cortical astrocytes to induce BDNF expression, CREB signaling and morphological transformation. Koppel I, Jaanson K, Klasche A, Tuvikene J, Tiirik T, Parn A, Timmusk T. Glia. 2018 Jan;66(1):206-216. doi: 10.1002/glia.23238. Epub 2017 Oct 6. PubMed |
| Combined CRISPRi/a-Based Chemical Genetic Screens Reveal that Rigosertib Is a Microtubule-Destabilizing Agent. Jost M, Chen Y, Gilbert LA, Horlbeck MA, Krenning L, Menchon G, Rai A, Cho MY, Stern JJ, Prota AE, Kampmann M, Akhmanova A, Steinmetz MO, Tanenbaum ME, Weissman JS. Mol Cell. 2017 Oct 5;68(1):210-223.e6. doi: 10.1016/j.molcel.2017.09.012. PubMed |
| Genetic and Functional Drivers of Diffuse Large B Cell Lymphoma. Reddy A, Zhang J, Davis NS, Moffitt AB, Love CL, Waldrop A, Leppa S, Pasanen A, Meriranta L, Karjalainen-Lindsberg ML, Norgaard P, Pedersen M, Gang AO, Hogdall E, Heavican TB, Lone W, Iqbal J, Qin Q, Li G, Kim SY, Healy J, Richards KL, Fedoriw Y, Bernal-Mizrachi L, Koff JL, Staton AD, Flowers CR, Paltiel O, Goldschmidt N, Calaminici M, Clear A, Gribben J, Nguyen E, Czader MB, Ondrejka SL, Collie A, Hsi ED, Tse E, Au-Yeung RKH, Kwong YL, Srivastava G, Choi WWL, Evens AM, Pilichowska M, Sengar M, Reddy N, Li S, Chadburn A, Gordon LI, Jaffe ES, Levy S, Rempel R, Tzeng T, Happ LE, Dave T, Rajagopalan D, Datta J, Dunson DB, Dave SS. Cell. 2017 Oct 5;171(2):481-494.e15. doi: 10.1016/j.cell.2017.09.027. PubMed |
| MicroRNA-7 inhibits cell proliferation of chronic myeloid leukemia and sensitizes it to imatinib in vitro. Jiang MJ, Dai JJ, Gu DN, Huang Q, Tian L. Biochem Biophys Res Commun. 2017 Dec 9;494(1-2):372-378. doi: 10.1016/j.bbrc.2017.10.001. Epub 2017 Oct 3. PubMed |
| ADAM8 expression in breast cancer derived brain metastases: Functional implications on MMP-9 expression and transendothelial migration in breast cancer cells. Conrad C, Gotte M, Schlomann U, Roessler M, Pagenstecher A, Anderson P, Preston J, Pruessmeyer J, Ludwig A, Li R, Kamm RD, Ritz R, Carl B, Nimsky C, Bartsch JW. Int J Cancer. 2018 Feb 15;142(4):779-791. doi: 10.1002/ijc.31090. Epub 2017 Oct 31. PubMed |
| CRISPR-Cas9 mediated gene knockout in human coronary artery endothelial cells reveals a pro-inflammatory role of TLR2. Wang Y, Chen L, Tian Z, Shen X, Wang X, Wu H, Wang Y, Zou J, Liang J. Cell Biol Int. 2018 Feb;42(2):187-193. doi: 10.1002/cbin.10885. Epub 2017 Nov 9. PubMed |
| ATF4-Induced Metabolic Reprograming Is a Synthetic Vulnerability of the p62-Deficient Tumor Stroma. Linares JF, Cordes T, Duran A, Reina-Campos M, Valencia T, Ahn CS, Castilla EA, Moscat J, Metallo CM, Diaz-Meco MT. Cell Metab. 2017 Dec 5;26(6):817-829.e6. doi: 10.1016/j.cmet.2017.09.001. Epub 2017 Oct 5. PubMed |
CRISPR/Cas9 screening using unique molecular identifiers.
Schmierer B, Botla SK, Zhang J, Turunen M, Kivioja T, Taipale J.
Mol Syst Biol. 2017 Oct 9;13(10):945. doi: 10.15252/msb.20177834.
PubMed
Associated Plasmids |
| Cell Cycle-Dependent Tumor Engraftment and Migration Are Enabled by Aurora-A. Chu TLH, Connell M, Zhou L, He Z, Won J, Chen H, Rahavi SMR, Mohan P, Nemirovsky O, Fotovati A, Pujana MA, Reid GSD, Nielsen TO, Pante N, Maxwell CA. Mol Cancer Res. 2018 Jan;16(1):16-31. doi: 10.1158/1541-7786.MCR-17-0417. Epub 2017 Oct 9. PubMed |
| The Epstein-Barr Virus Regulome in Lymphoblastoid Cells. Jiang S, Zhou H, Liang J, Gerdt C, Wang C, Ke L, Schmidt SCS, Narita Y, Ma Y, Wang S, Colson T, Gewurz B, Li G, Kieff E, Zhao B. Cell Host Microbe. 2017 Oct 11;22(4):561-573.e4. doi: 10.1016/j.chom.2017.09.001. PubMed |
| ANO9/TMEM16J promotes tumourigenesis via EGFR and is a novel therapeutic target for pancreatic cancer. Jun I, Park HS, Piao H, Han JW, An MJ, Yun BG, Zhang X, Cha YH, Shin YK, Yook JI, Jung J, Gee HY, Park JS, Yoon DS, Jeung HC, Lee MG. Br J Cancer. 2017 Dec 5;117(12):1798-1809. doi: 10.1038/bjc.2017.355. Epub 2017 Oct 12. PubMed |
| BRCA1 or CDK12 loss sensitizes cells to CHK1 inhibitors. Paculova H, Kramara J, Simeckova S, Fedr R, Soucek K, Hylse O, Paruch K, Svoboda M, Mistrik M, Kohoutek J. Tumour Biol. 2017 Oct;39(10):1010428317727479. doi: 10.1177/1010428317727479. PubMed |
| Modulation of the NF-kappaB signaling pathway by the HIV-2 envelope glycoprotein and its incomplete BST-2 antagonism. Dufrasne FE, Lucchetti M, Martin A, Andre E, Dessilly G, Kabamba B, Goubau P, Ruelle J. Virology. 2018 Jan 1;513:11-16. doi: 10.1016/j.virol.2017.09.024. Epub 2017 Oct 11. PubMed |
| Merkel cell polyomavirus recruits MYCL to the EP400 complex to promote oncogenesis. Cheng J, Park DE, Berrios C, White EA, Arora R, Yoon R, Branigan T, Xiao T, Westerling T, Federation A, Zeid R, Strober B, Swanson SK, Florens L, Bradner JE, Brown M, Howley PM, Padi M, Washburn MP, DeCaprio JA. PLoS Pathog. 2017 Oct 13;13(10):e1006668. doi: 10.1371/journal.ppat.1006668. eCollection 2017 Oct. PubMed |
| Ebola virus requires phosphatidylinositol (3,5) bisphosphate production for efficient viral entry. Qiu S, Leung A, Bo Y, Kozak RA, Anand SP, Warkentin C, Salambanga FDR, Cui J, Kobinger G, Kobasa D, Cote M. Virology. 2018 Jan 1;513:17-28. doi: 10.1016/j.virol.2017.09.028. Epub 2017 Oct 12. PubMed |
| Widespread Post-transcriptional Attenuation of Genomic Copy-Number Variation in Cancer. Goncalves E, Fragoulis A, Garcia-Alonso L, Cramer T, Saez-Rodriguez J, Beltrao P. Cell Syst. 2017 Oct 25;5(4):386-398.e4. doi: 10.1016/j.cels.2017.08.013. Epub 2017 Oct 11. PubMed |
| Genome-Nuclear Lamina Interactions Regulate Cardiac Stem Cell Lineage Restriction. Poleshko A, Shah PP, Gupta M, Babu A, Morley MP, Manderfield LJ, Ifkovits JL, Calderon D, Aghajanian H, Sierra-Pagan JE, Sun Z, Wang Q, Li L, Dubois NC, Morrisey EE, Lazar MA, Smith CL, Epstein JA, Jain R. Cell. 2017 Oct 19;171(3):573-587.e14. doi: 10.1016/j.cell.2017.09.018. Epub 2017 Oct 12. PubMed |
| Very Long Chain Fatty Acids Are Functionally Involved in Necroptosis. Parisi LR, Li N, Atilla-Gokcumen GE. Cell Chem Biol. 2017 Dec 21;24(12):1445-1454.e8. doi: 10.1016/j.chembiol.2017.08.026. Epub 2017 Oct 12. PubMed |
CRISPR/Cas9-mediated gene knockout is insensitive to target copy number but is dependent on guide RNA potency and Cas9/sgRNA threshold expression level.
Yuen G, Khan FJ, Gao S, Stommel JM, Batchelor E, Wu X, Luo J.
Nucleic Acids Res. 2017 Nov 16;45(20):12039-12053. doi: 10.1093/nar/gkx843.
PubMed
Associated Plasmids |
| TRIM29 promotes DNA virus infections by inhibiting innate immune response. Xing J, Zhang A, Zhang H, Wang J, Li XC, Zeng MS, Zhang Z. Nat Commun. 2017 Oct 16;8(1):945. doi: 10.1038/s41467-017-00101-w. PubMed |
| Assembly of the WHIP-TRIM14-PPP6C Mitochondrial Complex Promotes RIG-I-Mediated Antiviral Signaling. Tan P, He L, Cui J, Qian C, Cao X, Lin M, Zhu Q, Li Y, Xing C, Yu X, Wang HY, Wang RF. Mol Cell. 2017 Oct 19;68(2):293-307.e5. doi: 10.1016/j.molcel.2017.09.035. PubMed |
| TGF-beta receptor I/II trafficking and signaling at primary cilia are inhibited by ceramide to attenuate cell migration and tumor metastasis. Gencer S, Oleinik N, Kim J, Panneer Selvam S, De Palma R, Dany M, Nganga R, Thomas RJ, Senkal CE, Howe PH, Ogretmen B. Sci Signal. 2017 Oct 24;10(502). pii: 10/502/eaam7464. doi: 10.1126/scisignal.aam7464. PubMed |
| Optimization of trans-Splicing for Huntington's Disease RNA Therapy. Rindt H, Tom CM, Lorson CL, Mattis VB. Front Neurosci. 2017 Oct 10;11:544. doi: 10.3389/fnins.2017.00544. eCollection 2017. PubMed |
| UTX-guided neural crest function underlies craniofacial features of Kabuki syndrome. Shpargel KB, Starmer J, Wang C, Ge K, Magnuson T. Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):E9046-E9055. doi: 10.1073/pnas.1705011114. Epub 2017 Oct 9. PubMed |
| Design, Assembly, Production, and Transfection of Synthetic Modified mRNA. Oh S, Kessler JA. Methods. 2018 Jan 15;133:29-43. doi: 10.1016/j.ymeth.2017.10.008. Epub 2017 Nov 7. PubMed |
| The long non-coding RNA ROCR contributes to SOX9 expression and chondrogenic differentiation of human mesenchymal stem cells. Barter MJ, Gomez R, Hyatt S, Cheung K, Skelton AJ, Xu Y, Clark IM, Young DA. Development. 2017 Dec 15;144(24):4510-4521. doi: 10.1242/dev.152504. Epub 2017 Oct 30. PubMed |
| APC downregulated 1 inhibits breast cancer cell invasion by inhibiting the canonical WNT signaling pathway. Cho SG. Oncol Lett. 2017 Oct;14(4):4845-4852. doi: 10.3892/ol.2017.6801. Epub 2017 Aug 23. PubMed |
| A vimentin binding small molecule leads to mitotic disruption in mesenchymal cancers. Bollong MJ, Pietila M, Pearson AD, Sarkar TR, Ahmad I, Soundararajan R, Lyssiotis CA, Mani SA, Schultz PG, Lairson LL. Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):E9903-E9912. doi: 10.1073/pnas.1716009114. Epub 2017 Oct 30. PubMed |
| Parallel genome-wide screens identify synthetic viable interactions between the BLM helicase complex and Fanconi anemia. Moder M, Velimezi G, Owusu M, Mazouzi A, Wiedner M, Ferreira da Silva J, Robinson-Garcia L, Schischlik F, Slavkovsky R, Kralovics R, Schuster M, Bock C, Ideker T, Jackson SP, Menche J, Loizou JI. Nat Commun. 2017 Nov 1;8(1):1238. doi: 10.1038/s41467-017-01439-x. PubMed |
| DNA Barcoding Reveals Habitual Clonal Dominance of Myeloma Plasma Cells in the Bone Marrow Microenvironment. Hewett DR, Vandyke K, Lawrence DM, Friend N, Noll JE, Geoghegan JM, Croucher PI, Zannettino ACW. Neoplasia. 2017 Dec;19(12):972-981. doi: 10.1016/j.neo.2017.09.004. Epub 2017 Nov 5. PubMed |
| Involvement of Zizimin2/3 in the age-related defect of peritoneal B-1a cells as a source of anti-bacterial IgM. Sakamoto A, Matsuda T, Kawaguchi K, Takaoka A, Maruyama M. Int Immunol. 2017 Nov 1;29(9):431-438. doi: 10.1093/intimm/dxx054. PubMed |
| TGF-beta-Induced Quiescence Mediates Chemoresistance of Tumor-Propagating Cells in Squamous Cell Carcinoma. Brown JA, Yonekubo Y, Hanson N, Sastre-Perona A, Basin A, Rytlewski JA, Dolgalev I, Meehan S, Tsirigos A, Beronja S, Schober M. Cell Stem Cell. 2017 Nov 2;21(5):650-664.e8. doi: 10.1016/j.stem.2017.10.001. PubMed |
| In Vivo Survival of Human Endometrial Mesenchymal Stem Cells Transplanted Under the Kidney Capsule of Immunocompromised Mice. Gurung S, Deane JA, Darzi S, Werkmeister JA, Gargett CE. Stem Cells Dev. 2018 Jan 1;27(1):35-43. doi: 10.1089/scd.2017.0177. Epub 2017 Dec 5. PubMed |
| STK38L kinase ablation promotes loss of cell viability in a subset of KRAS-dependent pancreatic cancer cell lines. Grant TJ, Mehta AK, Gupta A, Sharif AAD, Arora KS, Deshpande V, Ting DT, Bardeesy N, Ganem NJ, Hergovich A, Singh A. Oncotarget. 2017 Sep 11;8(45):78556-78572. doi: 10.18632/oncotarget.20833. eCollection 2017 Oct 3. PubMed |
| Propagating Wave of ERK Activation Orients Collective Cell Migration. Aoki K, Kondo Y, Naoki H, Hiratsuka T, Itoh RE, Matsuda M. Dev Cell. 2017 Nov 6;43(3):305-317.e5. doi: 10.1016/j.devcel.2017.10.016. PubMed |
| Multitarget inhibition by four tandem shRNAs embedded in homo or heteromiRNA backbones. Du X, Cai Y, Xi W, Zhang R, Jia L, Yang A, Zhao J, Yan B. Mol Med Rep. 2018 Jan;17(1):307-314. doi: 10.3892/mmr.2017.7854. Epub 2017 Oct 20. PubMed |
A Map of Human Mitochondrial Protein Interactions Linked to Neurodegeneration Reveals New Mechanisms of Redox Homeostasis and NF-kappaB Signaling.
Malty RH, Aoki H, Kumar A, Phanse S, Amin S, Zhang Q, Minic Z, Goebels F, Musso G, Wu Z, Abou-Tok H, Meyer M, Deineko V, Kassir S, Sidhu V, Jessulat M, Scott NE, Xiong X, Vlasblom J, Prasad B, Foster LJ, Alberio T, Garavaglia B, Yu H, Bader GD, Nakamura K, Parkinson J, Babu M.
Cell Syst. 2017 Nov 7. pii: S2405-4712(17)30447-7. doi: 10.1016/j.cels.2017.10.010.
PubMed
Associated Plasmids |
| Deguelin, an Aurora B Kinase Inhibitor, Exhibits Potent Anti-Tumor Effect in Human Esophageal Squamous Cell Carcinoma. Yu X, Liang Q, Liu W, Zhou L, Li W, Liu H. EBioMedicine. 2017 Dec;26:100-111. doi: 10.1016/j.ebiom.2017.10.030. Epub 2017 Nov 3. PubMed |
| Nonimmune cells equipped with T-cell-receptor-like signaling for cancer cell ablation. Kojima R, Scheller L, Fussenegger M. Nat Chem Biol. 2018 Jan;14(1):42-49. doi: 10.1038/nchembio.2498. Epub 2017 Nov 13. PubMed |
| Loss of E-cadherin provides tolerance to centrosome amplification in epithelial cancer cells. Rhys AD, Monteiro P, Smith C, Vaghela M, Arnandis T, Kato T, Leitinger B, Sahai E, McAinsh A, Charras G, Godinho SA. J Cell Biol. 2018 Jan 2;217(1):195-209. doi: 10.1083/jcb.201704102. Epub 2017 Nov 13. PubMed |
| Chemokine Signaling Facilitates Early-Stage Breast Cancer Survival and Invasion through Fibroblast-Dependent Mechanisms. Brummer G, Acevedo DS, Hu Q, Portsche M, Fang WB, Yao M, Zinda B, Myers M, Alvarez N, Fields P, Hong Y, Behbod F, Cheng N. Mol Cancer Res. 2018 Feb;16(2):296-308. doi: 10.1158/1541-7786.MCR-17-0308. Epub 2017 Nov 13. PubMed |
| JNK Promotes Epithelial Cell Anoikis by Transcriptional and Post-translational Regulation of BH3-Only Proteins. Girnius N, Davis RJ. Cell Rep. 2017 Nov 14;21(7):1910-1921. doi: 10.1016/j.celrep.2017.10.067. PubMed |
| Salt bridges gate alpha-catenin activation at intercellular junctions. Barrick S, Li J, Kong X, Ray A, Tajkhorshid E, Leckband D. Mol Biol Cell. 2018 Jan 15;29(2):111-122. doi: 10.1091/mbc.E17-03-0168. Epub 2017 Nov 15. PubMed |
| BCAT1 restricts alphaKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation. Raffel S, Falcone M, Kneisel N, Hansson J, Wang W, Lutz C, Bullinger L, Poschet G, Nonnenmacher Y, Barnert A, Bahr C, Zeisberger P, Przybylla A, Sohn M, Tonjes M, Erez A, Adler L, Jensen P, Scholl C, Frohling S, Cocciardi S, Wuchter P, Thiede C, Florcken A, Westermann J, Ehninger G, Lichter P, Hiller K, Hell R, Herrmann C, Ho AD, Krijgsveld J, Radlwimmer B, Trumpp A. Nature. 2017 Nov 16;551(7680):384-388. doi: 10.1038/nature24294. Epub 2017 Nov 8. PubMed |
| Cre-dependent Cas9-expressing pigs enable efficient in vivo genome editing. Wang K, Jin Q, Ruan D, Yang Y, Liu Q, Wu H, Zhou Z, Ouyang Z, Liu Z, Zhao Y, Zhao B, Zhang Q, Peng J, Lai C, Fan N, Liang Y, Lan T, Li N, Wang X, Wang X, Fan Y, Doevendans PA, Sluijter JPG, Liu P, Li X, Lai L. Genome Res. 2017 Dec;27(12):2061-2071. doi: 10.1101/gr.222521.117. Epub 2017 Nov 16. PubMed |
| Harnessing BET Inhibitor Sensitivity Reveals AMIGO2 as a Melanoma Survival Gene. Fontanals-Cirera B, Hasson D, Vardabasso C, Di Micco R, Agrawal P, Chowdhury A, Gantz M, de Pablos-Aragoneses A, Morgenstern A, Wu P, Filipescu D, Valle-Garcia D, Darvishian F, Roe JS, Davies MA, Vakoc CR, Hernando E, Bernstein E. Mol Cell. 2017 Nov 16;68(4):731-744.e9. doi: 10.1016/j.molcel.2017.11.004. PubMed |
| Glutaminase inhibition in multiple myeloma induces apoptosis via MYC degradation. Effenberger M, Bommert KS, Kunz V, Kruk J, Leich E, Rudelius M, Bargou R, Bommert K. Oncotarget. 2017 Aug 24;8(49):85858-85867. doi: 10.18632/oncotarget.20691. eCollection 2017 Oct 17. PubMed |
| 3D collagen architecture induces a conserved migratory and transcriptional response linked to vasculogenic mimicry. Velez DO, Tsui B, Goshia T, Chute CL, Han A, Carter H, Fraley SI. Nat Commun. 2017 Nov 21;8(1):1651. doi: 10.1038/s41467-017-01556-7. PubMed |
| Nicotinic Acetylcholine Receptor Subtype Alpha-9 Mediates Triple-Negative Breast Cancers Based on a Spontaneous Pulmonary Metastasis Mouse Model. Huang LC, Lin CL, Qiu JZ, Lin CY, Hsu KW, Tam KW, Lee JY, Yang JM, Lee CH. Front Cell Neurosci. 2017 Nov 3;11:336. doi: 10.3389/fncel.2017.00336. eCollection 2017. PubMed |
| Foot-and-mouth disease virus capsid protein VP2 activates the cellular EIF2S1-ATF4 pathway and induces autophagy via HSPB1. Sun P, Zhang S, Qin X, Chang X, Cui X, Li H, Zhang S, Gao H, Wang P, Zhang Z, Luo J, Li Z. Autophagy. 2018;14(2):336-346. doi: 10.1080/15548627.2017.1405187. Epub 2018 Jan 29. PubMed |
| Epigenetic targeting of bromodomain protein BRD4 counteracts cancer cachexia and prolongs survival. Segatto M, Fittipaldi R, Pin F, Sartori R, Dae Ko K, Zare H, Fenizia C, Zanchettin G, Pierobon ES, Hatakeyama S, Sperti C, Merigliano S, Sandri M, Filippakopoulos P, Costelli P, Sartorelli V, Caretti G. Nat Commun. 2017 Nov 22;8(1):1707. doi: 10.1038/s41467-017-01645-7. PubMed |
| Vacuolar protein sorting 13C is a novel lipid droplet protein that inhibits lipolysis in brown adipocytes. Ramseyer VD, Kimler VA, Granneman JG. Mol Metab. 2018 Jan;7:57-70. doi: 10.1016/j.molmet.2017.10.014. Epub 2017 Nov 12. PubMed |
| Quantitative Profiling of Chaperone/Client Interactions with LUMIER Assay. Taipale M. Methods Mol Biol. 2018;1709:47-58. doi: 10.1007/978-1-4939-7477-1_4. PubMed |
| Live imaging analysis of human gastric epithelial spheroids reveals spontaneous rupture, rotation and fusion events. Sebrell TA, Sidar B, Bruns R, Wilkinson RA, Wiedenheft B, Taylor PJ, Perrino BA, Samuelson LC, Wilking JN, Bimczok D. Cell Tissue Res. 2018 Feb;371(2):293-307. doi: 10.1007/s00441-017-2726-5. Epub 2017 Nov 25. PubMed |
| Migration against the direction of flow is LFA-1-dependent in human hematopoietic stem and progenitor cells. Buffone A Jr, Anderson NR, Hammer DA. J Cell Sci. 2018 Jan 10;131(1). pii: jcs.205575. doi: 10.1242/jcs.205575. PubMed |
| The ATPase activity of Asna1/TRC40 is required for pancreatic progenitor cell survival. Norlin S, Parekh V, Edlund H. Development. 2018 Jan 3;145(1). pii: dev.154468. doi: 10.1242/dev.154468. PubMed |
| Smad4 SUMOylation is essential for memory formation through upregulation of the skeletal myopathy gene TPM2. Hsu WL, Ma YL, Liu YC, Lee EHY. BMC Biol. 2017 Nov 28;15(1):112. doi: 10.1186/s12915-017-0452-9. PubMed |
| Cardiopatch platform enables maturation and scale-up of human pluripotent stem cell-derived engineered heart tissues. Shadrin IY, Allen BW, Qian Y, Jackman CP, Carlson AL, Juhas ME, Bursac N. Nat Commun. 2017 Nov 28;8(1):1825. doi: 10.1038/s41467-017-01946-x. PubMed |
| Inactivation of DNA repair triggers neoantigen generation and impairs tumour growth. Germano G, Lamba S, Rospo G, Barault L, Magri A, Maione F, Russo M, Crisafulli G, Bartolini A, Lerda G, Siravegna G, Mussolin B, Frapolli R, Montone M, Morano F, de Braud F, Amirouchene-Angelozzi N, Marsoni S, D'Incalci M, Orlandi A, Giraudo E, Sartore-Bianchi A, Siena S, Pietrantonio F, Di Nicolantonio F, Bardelli A. Nature. 2017 Dec 7;552(7683):116-120. doi: 10.1038/nature24673. Epub 2017 Nov 29. PubMed |
| p53 promotes AKT and SP1-dependent metabolism through the pentose phosphate pathway that inhibits apoptosis in response to Nutlin-3a. Duan L, Perez RE, Chen L, Blatter LA, Maki CG. J Mol Cell Biol. 2018 Aug 1;10(4):331-340. doi: 10.1093/jmcb/mjx051. PubMed |
| Crosstalk between developing vasculature and optogenetically engineered skeletal muscle improves muscle contraction and angiogenesis. Osaki T, Sivathanu V, Kamm RD. Biomaterials. 2018 Feb;156:65-76. doi: 10.1016/j.biomaterials.2017.11.041. Epub 2017 Nov 25. PubMed |
| Spindle associated membrane protein 1 (Samp1) is required for the differentiation of muscle cells. Jafferali MH, Figueroa RA, Hasan M, Hallberg E. Sci Rep. 2017 Nov 30;7(1):16655. doi: 10.1038/s41598-017-16746-y. PubMed |
| Protein-lysine methyltransferases G9a and GLP1 promote responses to DNA damage. Ginjala V, Rodriguez-Colon L, Ganguly B, Gangidi P, Gallina P, Al-Hraishawi H, Kulkarni A, Tang J, Gheeya J, Simhadri S, Yao M, Xia B, Ganesan S. Sci Rep. 2017 Nov 30;7(1):16613. doi: 10.1038/s41598-017-16480-5. PubMed |
| The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages. Evavold CL, Ruan J, Tan Y, Xia S, Wu H, Kagan JC. Immunity. 2018 Jan 16;48(1):35-44.e6. doi: 10.1016/j.immuni.2017.11.013. Epub 2017 Nov 28. PubMed |
| A population of innate myelolymphoblastoid effector cell expanded by inactivation of mTOR complex 1 in mice. Tang F, Zhang P, Ye P, Lazarski CA, Wu Q, Bergin IL, Bender TP, Hall MN, Cui Y, Zhang L, Jiang T, Liu Y, Zheng P. Elife. 2017 Dec 5;6. pii: 32497. doi: 10.7554/eLife.32497. PubMed |
| Comprehensive Analysis of Cytomegalovirus pp65 Antigen-Specific CD8(+) T Cell Responses According to Human Leukocyte Antigen Class I Allotypes and Intraindividual Dominance. Hyun SJ, Sohn HJ, Lee HJ, Lee SD, Kim S, Sohn DH, Hong CH, Choi H, Cho HI, Kim TG. Front Immunol. 2017 Nov 21;8:1591. doi: 10.3389/fimmu.2017.01591. eCollection 2017. PubMed |
| Chemical hypoxia-induced integrated stress response activation in oligodendrocytes is mediated by the transcription factor nuclear factor (erythroid-derived 2)-like 2 (NRF2). Teske N, Liessem A, Fischbach F, Clarner T, Beyer C, Wruck C, Fragoulis A, Tauber SC, Victor M, Kipp M. J Neurochem. 2018 Feb;144(3):285-301. doi: 10.1111/jnc.14270. Epub 2018 Jan 5. PubMed |
| LDB2 inhibits proliferation and migration in liver cancer cells by abrogating HEY1 expression. Yu H, Jia R, Zhao L, Song S, Gu J, Zhang H. Oncotarget. 2017 Oct 10;8(55):94440-94449. doi: 10.18632/oncotarget.21772. eCollection 2017 Nov 7. PubMed |
| Cytoplasmic Linker Protein CLIP170 Negatively Regulates TLR4 Signaling by Targeting the TLR Adaptor Protein TIRAP. Jakka P, Bhargavi B, Namani S, Murugan S, Splitter G, Radhakrishnan G. J Immunol. 2018 Jan 15;200(2):704-714. doi: 10.4049/jimmunol.1601559. Epub 2017 Dec 8. PubMed |
| Conserved Gene Microsynteny Unveils Functional Interaction Between Protein Disulfide Isomerase and Rho Guanine-Dissociation Inhibitor Families. Moretti AIS, Pavanelli JC, Nolasco P, Leisegang MS, Tanaka LY, Fernandes CG, Wosniak J Jr, Kajihara D, Dias MH, Fernandes DC, Jo H, Tran NV, Ebersberger I, Brandes RP, Bonatto D, Laurindo FRM. Sci Rep. 2017 Dec 8;7(1):17262. doi: 10.1038/s41598-017-16947-5. PubMed |
| Next-Generation Sequencing of Genome-Wide CRISPR Screens. Yau EH, Rana TM. Methods Mol Biol. 2018;1712:203-216. doi: 10.1007/978-1-4939-7514-3_13. PubMed |
YY1 Is a Structural Regulator of Enhancer-Promoter Loops.
Weintraub AS, Li CH, Zamudio AV, Sigova AA, Hannett NM, Day DS, Abraham BJ, Cohen MA, Nabet B, Buckley DL, Guo YE, Hnisz D, Jaenisch R, Bradner JE, Gray NS, Young RA.
Cell. 2017 Dec 14;171(7):1573-1588.e28. doi: 10.1016/j.cell.2017.11.008. Epub 2017 Dec 7.
PubMed
Associated Plasmids |
| Lysyl oxidase-like 3 is required for melanoma cell survival by maintaining genomic stability. Santamaria PG, Floristan A, Fontanals-Cirera B, Vazquez-Naharro A, Santos V, Morales S, Yuste L, Peinado H, Garcia-Gomez A, Portillo F, Hernando E, Cano A. Cell Death Differ. 2017 Dec 11. pii: 10.1038/s41418-017-0030-2. doi: 10.1038/s41418-017-0030-2. PubMed |
| Synthetic Lethality of Combined Bcl-2 Inhibition and p53 Activation in AML: Mechanisms and Superior Antileukemic Efficacy. Pan R, Ruvolo V, Mu H, Leverson JD, Nichols G, Reed JC, Konopleva M, Andreeff M. Cancer Cell. 2017 Dec 11;32(6):748-760.e6. doi: 10.1016/j.ccell.2017.11.003. PubMed |
| Probing the requirement for CD38 in retinoic acid-induced HL-60 cell differentiation with a small molecule dimerizer and genetic knockout. MacDonald RJ, Shrimp JH, Jiang H, Zhang L, Lin H, Yen A. Sci Rep. 2017 Dec 12;7(1):17406. doi: 10.1038/s41598-017-17720-4. PubMed |
| Breast cancer metastasis suppressor OTUD1 deubiquitinates SMAD7. Zhang Z, Fan Y, Xie F, Zhou H, Jin K, Shao L, Shi W, Fang P, Yang B, van Dam H, Ten Dijke P, Zheng X, Yan X, Jia J, Zheng M, Jin J, Ding C, Ye S, Zhou F, Zhang L. Nat Commun. 2017 Dec 13;8(1):2116. doi: 10.1038/s41467-017-02029-7. PubMed |
| Interaction of porcine reproductive and respiratory syndrome virus proteins with SUMO-conjugating enzyme reveals the SUMOylation of nucleocapsid protein. Wang C, Zeng N, Liu S, Miao Q, Zhou L, Ge X, Han J, Guo X, Yang H. PLoS One. 2017 Dec 13;12(12):e0189191. doi: 10.1371/journal.pone.0189191. eCollection 2017. PubMed |
| Dual repression of endocytic players by ESCC microRNAs and the Polycomb complex regulates mouse embryonic stem cell pluripotency. Mote RD, Mahajan G, Padmanabhan A, Ambati R, Subramanyam D. Sci Rep. 2017 Dec 14;7(1):17572. doi: 10.1038/s41598-017-17828-7. PubMed |
| Cell-penetrating peptides derived from Clostridium difficile TcdB2 and a related large clostridial toxin. Larabee JL, Hauck GD, Ballard JD. J Biol Chem. 2018 Feb 2;293(5):1810-1819. doi: 10.1074/jbc.M117.815373. Epub 2017 Dec 15. PubMed |
| Protective role of FKBP51 in calcium entry-induced endothelial barrier disruption. Hamilton CL, Kadeba PI, Vasauskas AA, Solodushko V, McClinton AK, Alexeyev M, Scammell JG, Cioffi DL. Pulm Circ. 2018 Jan-Mar;8(1):2045893217749987. doi: 10.1177/2045893217749987. Epub 2017 Dec 20. PubMed |
| Cucurbitacin B and SCH772984 exhibit synergistic anti-pancreatic cancer activities by suppressing EGFR, PI3K/Akt/mTOR, STAT3 and ERK signaling. Zhou J, Zhao T, Ma L, Liang M, Guo YJ, Zhao LM. Oncotarget. 2017 Oct 9;8(61):103167-103181. doi: 10.18632/oncotarget.21704. eCollection 2017 Nov 28. PubMed |
| ABR, a novel inducer of transcription factor C/EBPalpha, contributes to myeloid differentiation and is a favorable prognostic factor in acute myeloid leukemia. Namasu CY, Katzerke C, Brauer-Hartmann D, Wurm AA, Gerloff D, Hartmann JU, Schwind S, Muller-Tidow C, Hilger N, Fricke S, Christopeit M, Niederwieser D, Behre G. Oncotarget. 2017 Oct 26;8(61):103626-103639. doi: 10.18632/oncotarget.22093. eCollection 2017 Nov 28. PubMed |
| Emerging Alphaviruses Are Sensitive to Cellular States Induced by a Novel Small-Molecule Agonist of the STING Pathway. Gall B, Pryke K, Abraham J, Mizuno N, Botto S, Sali TM, Broeckel R, Haese N, Nilsen A, Placzek A, Morrison T, Heise M, Streblow D, DeFilippis V. J Virol. 2018 Feb 26;92(6). pii: JVI.01913-17. doi: 10.1128/JVI.01913-17. Print 2018 Mar 15. PubMed |
| Genomic and Proteomic Resolution of Heterochromatin and Its Restriction of Alternate Fate Genes. Becker JS, McCarthy RL, Sidoli S, Donahue G, Kaeding KE, He Z, Lin S, Garcia BA, Zaret KS. Mol Cell. 2017 Dec 21;68(6):1023-1037.e15. doi: 10.1016/j.molcel.2017.11.030. PubMed |
| TRAIL induces apoptosis but not necroptosis in colorectal and pancreatic cancer cells preferentially via the TRAIL-R2/DR5 receptor. Nahacka Z, Svadlenka J, Peterka M, Ksandrova M, Benesova S, Neuzil J, Andera L. Biochim Biophys Acta. 2018 Mar;1865(3):522-531. doi: 10.1016/j.bbamcr.2017.12.006. Epub 2017 Dec 24. PubMed |
| Reversible dual inhibitor against G9a and DNMT1 improves human iPSC derivation enhancing MET and facilitating transcription factor engagement to the genome. Rodriguez-Madoz JR, San Jose-Eneriz E, Rabal O, Zapata-Linares N, Miranda E, Rodriguez S, Porciuncula A, Vilas-Zornoza A, Garate L, Segura V, Guruceaga E, Agirre X, Oyarzabal J, Prosper F. PLoS One. 2017 Dec 27;12(12):e0190275. doi: 10.1371/journal.pone.0190275. eCollection 2017. PubMed |
| A Targeted RNAi Screen Identifies Endocytic Trafficking Factors That Control GLP-1 Receptor Signaling in Pancreatic beta-Cells. Buenaventura T, Kanda N, Douzenis PC, Jones B, Bloom SR, Chabosseau P, Correa IR Jr., Bosco D, Piemonti L, Marchetti P, Johnson PR, Shapiro AMJ, Rutter GA, Tomas A. Diabetes. 2018 Mar;67(3):385-399. doi: 10.2337/db17-0639. Epub 2017 Dec 28. PubMed |
| A Protocol for the Production of Integrase-deficient Lentiviral Vectors for CRISPR/Cas9-mediated Gene Knockout in Dividing Cells. Vijayraghavan S, Kantor B. J Vis Exp. 2017 Dec 12;(130). doi: 10.3791/56915. PubMed |
| The role of host DNA ligases in hepadnavirus covalently closed circular DNA formation. Long Q, Yan R, Hu J, Cai D, Mitra B, Kim ES, Marchetti A, Zhang H, Wang S, Liu Y, Huang A, Guo H. PLoS Pathog. 2017 Dec 29;13(12):e1006784. doi: 10.1371/journal.ppat.1006784. eCollection 2017 Dec. PubMed |
| The p38 Mitogen-Activated Protein Kinase Critically Regulates Human Keratinocyte Inflammasome Activation. Fenini G, Grossi S, Gehrke S, Beer HD, Satoh TK, Contassot E, French LE. J Invest Dermatol. 2018 Jun;138(6):1380-1390. doi: 10.1016/j.jid.2017.10.037. Epub 2017 Dec 26. PubMed |
| CRISPR Screens Uncover Genes that Regulate Target Cell Sensitivity to the Morphogen Sonic Hedgehog. Pusapati GV, Kong JH, Patel BB, Krishnan A, Sagner A, Kinnebrew M, Briscoe J, Aravind L, Rohatgi R. Dev Cell. 2018 Jan 8;44(1):113-129.e8. doi: 10.1016/j.devcel.2017.12.003. Epub 2017 Dec 28. PubMed |
| Neurocan, an extracellular chondroitin sulfate proteoglycan, stimulates neuroblastoma cells to promote malignant phenotypes. Su Z, Kishida S, Tsubota S, Sakamoto K, Cao D, Kiyonari S, Ohira M, Kamijo T, Narita A, Xu Y, Takahashi Y, Kadomatsu K. Oncotarget. 2017 Nov 15;8(63):106296-106310. doi: 10.18632/oncotarget.22435. eCollection 2017 Dec 5. PubMed |
| Ultrawidefield microscope for high-speed fluorescence imaging and targeted optogenetic stimulation. Werley CA, Chien MP, Cohen AE. Biomed Opt Express. 2017 Nov 29;8(12):5794-5813. doi: 10.1364/BOE.8.005794. eCollection 2017 Dec 1. PubMed |
| A Role for Myosin Va in Human Cytomegalovirus Nuclear Egress. Wilkie AR, Sharma M, Pesola JM, Ericsson M, Fernandez R, Coen DM. J Virol. 2018 Feb 26;92(6). pii: JVI.01849-17. doi: 10.1128/JVI.01849-17. Print 2018 Mar 15. PubMed |
| Colonoscopy-based colorectal cancer modeling in mice with CRISPR-Cas9 genome editing and organoid transplantation. Roper J, Tammela T, Akkad A, Almeqdadi M, Santos SB, Jacks T, Yilmaz OH. Nat Protoc. 2018 Feb;13(2):217-234. doi: 10.1038/nprot.2017.136. Epub 2018 Jan 4. PubMed |
Multiple Chemical Inducible Tal Effectors for Genome Editing and Transcription Activation.
Zhao C, Zhang Y, Zhao Y, Ying Y, Ai R, Zhang J, Wang Y.
ACS Chem Biol. 2018 Mar 16;13(3):609-617. doi: 10.1021/acschembio.7b00606. Epub 2018 Jan 8.
PubMed
Associated Plasmids |
| Development and characterization of a novel luciferase based cytotoxicity assay. Matta H, Gopalakrishnan R, Choi S, Prakash R, Natarajan V, Prins R, Gong S, Chitnis SD, Kahn M, Han X, Chaudhary V, Soni A, Sernas J, Khan P, Wang D, Chaudhary PM. Sci Rep. 2018 Jan 9;8(1):199. doi: 10.1038/s41598-017-18606-1. PubMed |
| Tousled-like kinase 1 is a negative regulator of core transcription factors in murine embryonic stem cells. Lee J, Kim MS, Park SH, Jang YK. Sci Rep. 2018 Jan 10;8(1):334. doi: 10.1038/s41598-017-18628-9. PubMed |
| The interactome of EBV LMP1 evaluated by proximity-based BioID approach. Rider MA, Cheerathodi MR, Hurwitz SN, Nkosi D, Howell LA, Tremblay DC, Liu X, Zhu F, Meckes DG Jr. Virology. 2018 Mar;516:55-70. doi: 10.1016/j.virol.2017.12.033. Epub 2018 Jan 9. PubMed |
| Frequent overexpression of AMAP1, an Arf6 effector in cell invasion, is characteristic of the MMTV-PyMT rather than the MMTV-Neu human breast cancer model. Otsuka Y, Oikawa T, Yoshino H, Hashimoto S, Handa H, Yamamoto H, Hashimoto A, Sabe H. Cell Commun Signal. 2018 Jan 5;16(1):1. doi: 10.1186/s12964-017-0212-z. PubMed |
| Foxo-dependent Par-4 Upregulation Prevents Long-term Survival of Residual Cells Following PI3K-Akt Inhibition. Damrauer JS, Phelps SN, Amuchastegui K, Lupo R, Mabe NW, Walens A, Kroger BR, Alvarez JV. Mol Cancer Res. 2018 Apr;16(4):599-609. doi: 10.1158/1541-7786.MCR-17-0492. Epub 2018 Jan 12. PubMed |
| High STAP1 expression in DUX4-rearranged cases is not suitable as therapeutic target in pediatric B-cell precursor acute lymphoblastic leukemia. Steeghs EMP, Bakker M, Hoogkamer AQ, Boer JM, Hartman QJ, Stalpers F, Escherich G, de Haas V, de Groot-Kruseman HA, Pieters R, den Boer ML. Sci Rep. 2018 Jan 12;8(1):693. doi: 10.1038/s41598-017-17704-4. PubMed |
Dual gene activation and knockout screen reveals directional dependencies in genetic networks.
Boettcher M, Tian R, Blau JA, Markegard E, Wagner RT, Wu D, Mo X, Biton A, Zaitlen N, Fu H, McCormick F, Kampmann M, McManus MT.
Nat Biotechnol. 2018 Jan 15. pii: nbt.4062. doi: 10.1038/nbt.4062.
PubMed
Associated Plasmids |
In vivo simultaneous transcriptional activation of multiple genes in the brain using CRISPR-dCas9-activator transgenic mice.
Zhou H, Liu J, Zhou C, Gao N, Rao Z, Li H, Hu X, Li C, Yao X, Shen X, Sun Y, Wei Y, Liu F, Ying W, Zhang J, Tang C, Zhang X, Xu H, Shi L, Cheng L, Huang P, Yang H.
Nat Neurosci. 2018 Jan 15. pii: 10.1038/s41593-017-0060-6. doi: 10.1038/s41593-017-0060-6.
PubMed
Associated Plasmids |
| Temporal Layering of Signaling Effectors Drives Chromatin Remodeling during Hair Follicle Stem Cell Lineage Progression. Adam RC, Yang H, Ge Y, Lien WH, Wang P, Zhao Y, Polak L, Levorse J, Baksh SC, Zheng D, Fuchs E. Cell Stem Cell. 2018 Mar 1;22(3):398-413.e7. doi: 10.1016/j.stem.2017.12.004. Epub 2018 Jan 11. PubMed |
| CRISPR/Cas9-Mediated Genome Editing in Epstein-Barr Virus-Transformed Lymphoblastoid B-Cell Lines. Jiang S, Wang LW, Walsh MJ, Trudeau SJ, Gerdt C, Zhao B, Gewurz BE. Curr Protoc Mol Biol. 2018 Jan 16;121:31.12.1-31.12.23. doi: 10.1002/cpmb.51. PubMed |
| PHD3 Controls Lung Cancer Metastasis and Resistance to EGFR Inhibitors through TGFalpha. Dopeso H, Jiao HK, Cuesta AM, Henze AT, Jurida L, Kracht M, Acker-Palmer A, Garvalov BK, Acker T. Cancer Res. 2018 Apr 1;78(7):1805-1819. doi: 10.1158/0008-5472.CAN-17-1346. Epub 2018 Jan 16. PubMed |
| Human caspase-4 detects tetra-acylated LPS and cytosolic Francisella and functions differently from murine caspase-11. Lagrange B, Benaoudia S, Wallet P, Magnotti F, Provost A, Michal F, Martin A, Di Lorenzo F, Py BF, Molinaro A, Henry T. Nat Commun. 2018 Jan 16;9(1):242. doi: 10.1038/s41467-017-02682-y. PubMed |
| Human Herpesvirus 8 Interferon Regulatory Factors 1 and 3 Mediate Replication and Latency Activities via Interactions with USP7 Deubiquitinase. Xiang Q, Ju H, Li Q, Mei SC, Chen D, Choi YB, Nicholas J. J Virol. 2018 Mar 14;92(7). pii: JVI.02003-17. doi: 10.1128/JVI.02003-17. Print 2018 Apr 1. PubMed |
| The protective role of DOT1L in UV-induced melanomagenesis. Zhu B, Chen S, Wang H, Yin C, Han C, Peng C, Liu Z, Wan L, Zhang X, Zhang J, Lian CG, Ma P, Xu ZX, Prince S, Wang T, Gao X, Shi Y, Liu D, Liu M, Wei W, Wei Z, Pan J, Wang Y, Xuan Z, Hess J, Hayward NK, Goding CR, Chen X, Zhou J, Cui R. Nat Commun. 2018 Jan 17;9(1):259. doi: 10.1038/s41467-017-02687-7. PubMed |
| CYR61/CCN1 Regulates Sclerostin Levels and Bone Maintenance. Zhao G, Huang BL, Rigueur D, Wang W, Bhoot C, Charles KR, Baek J, Mohan S, Jiang J, Lyons KM. J Bone Miner Res. 2018 Jun;33(6):1076-1089. doi: 10.1002/jbmr.3394. Epub 2018 Mar 5. PubMed |
| The RIG-I-like receptor LGP2 inhibits Dicer-dependent processing of long double-stranded RNA and blocks RNA interference in mammalian cells. van der Veen AG, Maillard PV, Schmidt JM, Lee SA, Deddouche-Grass S, Borg A, Kjaer S, Snijders AP, Reis E Sousa C. EMBO J. 2018 Feb 15;37(4). pii: embj.201797479. doi: 10.15252/embj.201797479. Epub 2018 Jan 19. PubMed |
| Unique properties of TCR-activated p38 are necessary for NFAT-dependent T-cell activation. Alam MS, Gaida MM, Debnath S, Tagad HD, Miller Jenkins LM, Appella E, Rahman MJ, Ashwell JD. PLoS Biol. 2018 Jan 22;16(1):e2004111. doi: 10.1371/journal.pbio.2004111. eCollection 2018 Jan. PubMed |
| Interferon regulatory factor 8 regulates caspase-1 expression to facilitate Epstein-Barr virus reactivation in response to B cell receptor stimulation and chemical induction. Lv DW, Zhang K, Li R. PLoS Pathog. 2018 Jan 22;14(1):e1006868. doi: 10.1371/journal.ppat.1006868. eCollection 2018 Jan. PubMed |
| CRISPR-Based Chromatin Remodeling of the Endogenous Oct4 or Sox2 Locus Enables Reprogramming to Pluripotency. Liu P, Chen M, Liu Y, Qi LS, Ding S. Cell Stem Cell. 2018 Feb 1;22(2):252-261.e4. doi: 10.1016/j.stem.2017.12.001. Epub 2018 Jan 18. PubMed |
| HNRNPH1 is required for rhabdomyosarcoma cell growth and survival. Li Y, Bakke J, Finkelstein D, Zeng H, Wu J, Chen T. Oncogenesis. 2018 Jan 24;7(1):9. doi: 10.1038/s41389-017-0024-4. PubMed |
| Human Papillomavirus 16 E7 Stabilizes APOBEC3A Protein by Inhibiting Cullin 2-Dependent Protein Degradation. Westrich JA, Warren CJ, Klausner MJ, Guo K, Liu CW, Santiago ML, Pyeon D. J Virol. 2018 Mar 14;92(7). pii: JVI.01318-17. doi: 10.1128/JVI.01318-17. Print 2018 Apr 1. PubMed |
| Rab18 promotes lipid droplet (LD) growth by tethering the ER to LDs through SNARE and NRZ interactions. Xu D, Li Y, Wu L, Li Y, Zhao D, Yu J, Huang T, Ferguson C, Parton RG, Yang H, Li P. J Cell Biol. 2018 Mar 5;217(3):975-995. doi: 10.1083/jcb.201704184. Epub 2018 Jan 24. PubMed |
| Melanoma antigen-D2 controls cell cycle progression and modulates the DNA damage response. Trussart C, Pirlot C, Di Valentin E, Piette J, Habraken Y. Biochem Pharmacol. 2018 Jul;153:217-229. doi: 10.1016/j.bcp.2018.01.035. Epub 2018 Feb 1. PubMed |
| Necessity of p53-binding to the CDH1 locus for its expression defines two epithelial cell types differing in their integrity. Oikawa T, Otsuka Y, Onodera Y, Horikawa M, Handa H, Hashimoto S, Suzuki Y, Sabe H. Sci Rep. 2018 Jan 25;8(1):1595. doi: 10.1038/s41598-018-20043-7. PubMed |
| ERAD-dependent control of the Wnt secretory factor Evi. Glaeser K, Urban M, Fenech E, Voloshanenko O, Kranz D, Lari F, Christianson JC, Boutros M. EMBO J. 2018 Feb 15;37(4). pii: embj.201797311. doi: 10.15252/embj.201797311. Epub 2018 Jan 29. PubMed |
| Dynamic evolution of regulatory element ensembles in primate CD4(+) T cells. Danko CG, Choate LA, Marks BA, Rice EJ, Wang Z, Chu T, Martins AL, Dukler N, Coonrod SA, Tait Wojno ED, Lis JT, Kraus WL, Siepel A. Nat Ecol Evol. 2018 Mar;2(3):537-548. doi: 10.1038/s41559-017-0447-5. Epub 2018 Jan 29. PubMed |
| Human ex vivo prostate tissue model system identifies ING3 as an oncoprotein. McClurg UL, Nabbi A, Ricordel C, Korolchuk S, McCracken S, Heer R, Wilson L, Butler LM, Irving-Hooper BK, Pedeux R, Robson CN, Riabowol KT, Binda O. Br J Cancer. 2018 Mar 6;118(5):713-726. doi: 10.1038/bjc.2017.447. Epub 2018 Jan 30. PubMed |
| Phosphatidylinositol-(4, 5)-bisphosphate regulates calcium gating of small-conductance cation channel TMEM16F. Ye W, Han TW, Nassar LM, Zubia M, Jan YN, Jan LY. Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):E1667-E1674. doi: 10.1073/pnas.1718728115. Epub 2018 Jan 30. PubMed |
| Polycomb protein RING1A limits hematopoietic differentiation in myelodysplastic syndromes. Palau A, Garz AK, Diesch J, Zwick A, Malinverni R, Valero V, Lappin K, Casquero R, Lennartsson A, Zuber J, Navarro T, Mills KI, Gotze KS, Buschbeck M. Oncotarget. 2017 Dec 1;8(70):115002-115017. doi: 10.18632/oncotarget.22839. eCollection 2017 Dec 29. PubMed |
| CD209a Synergizes with Dectin-2 and Mincle to Drive Severe Th17 Cell-Mediated Schistosome Egg-Induced Immunopathology. Kalantari P, Morales Y, Miller EA, Jaramillo LD, Ponichtera HE, Wuethrich MA, Cheong C, Seminario MC, Russo JM, Bunnell SC, Stadecker MJ. Cell Rep. 2018 Jan 30;22(5):1288-1300. doi: 10.1016/j.celrep.2018.01.001. PubMed |
| The Application of Non-Invasive Apoptosis Detection Sensor (NIADS) on Histone Deacetylation Inhibitor (HDACi)-Induced Breast Cancer Cell Death. Hsu KW, Huang CY, Tam KW, Lin CY, Huang LC, Lin CL, Hsieh WS, Chi WM, Chang YJ, Wei PL, Chen ST, Lee CH. Int J Mol Sci. 2018 Feb 2;19(2). pii: ijms19020452. doi: 10.3390/ijms19020452. PubMed |
| Inhibition of Dpp8/9 Activates the Nlrp1b Inflammasome. Okondo MC, Rao SD, Taabazuing CY, Chui AJ, Poplawski SE, Johnson DC, Bachovchin DA. Cell Chem Biol. 2018 Mar 15;25(3):262-267.e5. doi: 10.1016/j.chembiol.2017.12.013. Epub 2018 Jan 27. PubMed |
| Tuning microtubule dynamics to enhance cancer therapy by modulating FER-mediated CRMP2 phosphorylation. Zheng Y, Sethi R, Mangala LS, Taylor C, Goldsmith J, Wang M, Masuda K, Karaminejadranjbar M, Mannion D, Miranda F, Herrero-Gonzalez S, Hellner K, Chen F, Alsaadi A, Albukhari A, Fotso DC, Yau C, Jiang D, Pradeep S, Rodriguez-Aguayo C, Lopez-Berestein G, Knapp S, Gray NS, Campo L, Myers KA, Dhar S, Ferguson D, Bast RC Jr, Sood AK, von Delft F, Ahmed AA. Nat Commun. 2018 Feb 2;9(1):476. doi: 10.1038/s41467-017-02811-7. PubMed |
| In Situ Structure of Neuronal C9orf72 Poly-GA Aggregates Reveals Proteasome Recruitment. Guo Q, Lehmer C, Martinez-Sanchez A, Rudack T, Beck F, Hartmann H, Perez-Berlanga M, Frottin F, Hipp MS, Hartl FU, Edbauer D, Baumeister W, Fernandez-Busnadiego R. Cell. 2018 Feb 8;172(4):696-705.e12. doi: 10.1016/j.cell.2017.12.030. Epub 2018 Feb 1. PubMed |
| Losmapimod Overcomes Gefitinib Resistance in Non-small Cell Lung Cancer by Preventing Tetraploidization. Yeung YT, Yin S, Lu B, Fan S, Yang R, Bai R, Zhang C, Bode AM, Liu K, Dong Z. EBioMedicine. 2018 Feb;28:51-61. doi: 10.1016/j.ebiom.2018.01.017. Epub 2018 Feb 2. PubMed |
| Antiviral and anti-inflammatory activity of budesonide against human rhinovirus infection mediated via autophagy activation. Kim SR, Song JH, Ahn JH, Lee GS, Ahn H, Yoon SI, Kang SG, Kim PH, Jeon SM, Choi EJ, Shin S, Cha Y, Cho S, Kim DE, Chang SY, Ko HJ. Antiviral Res. 2018 Mar;151:87-96. doi: 10.1016/j.antiviral.2018.01.012. Epub 2018 Feb 3. PubMed |
| MAX to MYCN intracellular ratio drives the aggressive phenotype and clinical outcome of high risk neuroblastoma. Ferrucci F, Ciaccio R, Monticelli S, Pigini P, di Giacomo S, Purgato S, Erriquez D, Bernardoni R, Norris M, Haber M, Milazzo G, Perini G. Biochim Biophys Acta Gene Regul Mech. 2018 Mar;1861(3):235-245. doi: 10.1016/j.bbagrm.2018.01.007. Epub 2018 Feb 3. PubMed |
| Translational control of ERK signaling through miRNA/4EHP-directed silencing. Jafarnejad SM, Chapat C, Matta-Camacho E, Gelbart IA, Hesketh GG, Arguello M, Garzia A, Kim SH, Attig J, Shapiro M, Morita M, Khoutorsky A, Alain T, Gkogkas CG, Stern-Ginossar N, Tuschl T, Gingras AC, Duchaine TF, Sonenberg N. Elife. 2018 Feb 7;7. pii: 35034. doi: 10.7554/eLife.35034. PubMed |
| Lrp6 is a target of the PTH-activated alphaNAC transcriptional coregulator. Pellicelli M, Hariri H, Miller JA, St-Arnaud R. Biochim Biophys Acta Gene Regul Mech. 2018 Feb;1861(2):61-71. doi: 10.1016/j.bbagrm.2018.01.008. Epub 2018 Feb 3. PubMed |
| Picornavirus 2A protease regulates stress granule formation to facilitate viral translation. Yang X, Hu Z, Fan S, Zhang Q, Zhong Y, Guo D, Qin Y, Chen M. PLoS Pathog. 2018 Feb 7;14(2):e1006901. doi: 10.1371/journal.ppat.1006901. eCollection 2018 Feb. PubMed |
| The Role of Trio, a Rho Guanine Nucleotide Exchange Factor, in Glomerular Podocytes. Maier M, Baldwin C, Aoudjit L, Takano T. Int J Mol Sci. 2018 Feb 6;19(2). pii: ijms19020479. doi: 10.3390/ijms19020479. PubMed |
| Deguelin suppresses angiogenesis in human hepatocellular carcinoma by targeting HGF-c-Met pathway. Li M, Yu X, Li W, Liu T, Deng G, Liu W, Liu H, Gao F. Oncotarget. 2017 Oct 26;9(1):152-166. doi: 10.18632/oncotarget.22077. eCollection 2018 Jan 2. PubMed |
| Primary Airway Epithelial Cell Gene Editing Using CRISPR-Cas9. Everman JL, Rios C, Seibold MA. Methods Mol Biol. 2018;1706:267-292. doi: 10.1007/978-1-4939-7471-9_15. PubMed |
The TIA1 RNA-Binding Protein Family Regulates EIF2AK2-Mediated Stress Response and Cell Cycle Progression.
Meyer C, Garzia A, Mazzola M, Gerstberger S, Molina H, Tuschl T.
Mol Cell. 2018 Feb 15;69(4):622-635.e6. doi: 10.1016/j.molcel.2018.01.011.
PubMed
Associated Plasmids |
| Intratumoral Delivery of Interferongamma-Secreting Mesenchymal Stromal Cells Repolarizes Tumor-Associated Macrophages and Suppresses Neuroblastoma Proliferation In Vivo. Relation T, Yi T, Guess AJ, La Perle K, Otsuru S, Hasgur S, Dominici M, Breuer C, Horwitz EM. Stem Cells. 2018 Jun;36(6):915-924. doi: 10.1002/stem.2801. Epub 2018 Feb 27. PubMed |
| Knockdown of L1CAM significantly reduces metastasis in a xenograft model of human melanoma: L1CAM is a potential target for anti-melanoma therapy. Ernst AK, Putscher A, Samatov TR, Suling A, Galatenko VV, Shkurnikov MY, Knyazev EN, Tonevitsky AG, Haalck T, Lange T, Maar H, Schroder-Schwarz J, Riecken K, Schumacher U, Wicklein D. PLoS One. 2018 Feb 12;13(2):e0192525. doi: 10.1371/journal.pone.0192525. eCollection 2018. PubMed |
| microRNA-193a stimulates pancreatic cancer cell repopulation and metastasis through modulating TGF-beta2/TGF-betaRIII signalings. Fang C, Dai CY, Mei Z, Jiang MJ, Gu DN, Huang Q, Tian L. J Exp Clin Cancer Res. 2018 Feb 13;37(1):25. doi: 10.1186/s13046-018-0697-3. PubMed |
| MYL6B, a myosin light chain, promotes MDM2-mediated p53 degradation and drives HCC development. Xie X, Wang X, Liao W, Fei R, Wu N, Cong X, Chen Q, Wei L, Wang Y, Chen H. J Exp Clin Cancer Res. 2018 Feb 13;37(1):28. doi: 10.1186/s13046-018-0693-7. PubMed |
| SLAMF1 is required for TLR4-mediated TRAM-TRIF-dependent signaling in human macrophages. Yurchenko M, Skjesol A, Ryan L, Richard GM, Kandasamy RK, Wang N, Terhorst C, Husebye H, Espevik T. J Cell Biol. 2018 Apr 2;217(4):1411-1429. doi: 10.1083/jcb.201707027. Epub 2018 Feb 12. PubMed |
| En masse lentiviral gene delivery to mouse fertilized eggs via laser perforation of zona pellucida. Martin NP, Myers P, Goulding E, Chen SH, Walker M, Porter TM, Van Gorder L, Mathew A, Gruzdev A, Romeo C. Transgenic Res. 2018 Feb;27(1):39-49. doi: 10.1007/s11248-017-0056-8. Epub 2018 Feb 13. PubMed |
| Kinesin 1 regulates cilia length through an interaction with the Bardet-Biedl syndrome related protein CCDC28B. Novas R, Cardenas-Rodriguez M, Lepanto P, Fabregat M, Rodao M, Fariello MI, Ramos M, Davison C, Casanova G, Alfaya L, Lecumberry F, Gonzalez-Sapienza G, Irigoin F, Badano JL. Sci Rep. 2018 Feb 14;8(1):3019. doi: 10.1038/s41598-018-21329-6. PubMed |
| Dynamic network biomarker indicates pulmonary metastasis at the tipping point of hepatocellular carcinoma. Yang B, Li M, Tang W, Liu W, Zhang S, Chen L, Xia J. Nat Commun. 2018 Feb 14;9(1):678. doi: 10.1038/s41467-018-03024-2. PubMed |
| A paralogous pair of mammalian host restriction factors form a critical host barrier against poxvirus infection. Meng X, Zhang F, Yan B, Si C, Honda H, Nagamachi A, Sun LZ, Xiang Y. PLoS Pathog. 2018 Feb 15;14(2):e1006884. doi: 10.1371/journal.ppat.1006884. eCollection 2018 Feb. PubMed |
| HuR-mediated SCN5A messenger RNA stability reduces arrhythmic risk in heart failure. Zhou A, Xie A, Kim TY, Liu H, Shi G, Kang GJ, Jiang N, Liu M, Jeong EM, Choi BR, Dudley SC Jr. Heart Rhythm. 2018 Jul;15(7):1072-1080. doi: 10.1016/j.hrthm.2018.02.018. Epub 2018 Feb 16. PubMed |
| Chronic hyperinsulinemia induced miR-27b is linked to adipocyte insulin resistance by targeting insulin receptor. Srivastava A, Shankar K, Beg M, Rajan S, Gupta A, Varshney S, Kumar D, Gupta S, Mishra RK, Gaikwad AN. J Mol Med (Berl). 2018 Apr;96(3-4):315-331. doi: 10.1007/s00109-018-1623-z. Epub 2018 Feb 17. PubMed |
| The contribution of SP100 to cottontail rabbit papillomavirus transcription and replication. Wurdak M, Schneider M, Iftner T, Stubenrauch F. J Gen Virol. 2018 Jan 24. doi: 10.1099/jgv.0.001012. PubMed |
| A negative feedback regulation of MTORC1 activity by the lysosomal Ca(2+) channel MCOLN1 (mucolipin 1) using a CALM (calmodulin)-dependent mechanism. Sun X, Yang Y, Zhong XZ, Cao Q, Zhu XH, Zhu X, Dong XP. Autophagy. 2018;14(1):38-52. doi: 10.1080/15548627.2017.1389822. Epub 2018 Feb 20. PubMed |
| Clonal dynamics towards the development of venetoclax resistance in chronic lymphocytic leukemia. Herling CD, Abedpour N, Weiss J, Schmitt A, Jachimowicz RD, Merkel O, Cartolano M, Oberbeck S, Mayer P, Berg V, Thomalla D, Kutsch N, Stiefelhagen M, Cramer P, Wendtner CM, Persigehl T, Saleh A, Altmuller J, Nurnberg P, Pallasch C, Achter V, Lang U, Eichhorst B, Castiglione R, Schafer SC, Buttner R, Kreuzer KA, Reinhardt HC, Hallek M, Frenzel LP, Peifer M. Nat Commun. 2018 Feb 20;9(1):727. doi: 10.1038/s41467-018-03170-7. PubMed |
| sAPPbeta and sAPPalpha increase structural complexity and E/I input ratio in primary hippocampal neurons and alter Ca(2+) homeostasis and CREB1-signaling. Hesse R, von Einem B, Wagner F, Bott P, Schwanzar D, Jackson RJ, Fohr KJ, Lausser L, Kroker KS, Proepper C, Walther P, Kestler HA, Spires-Jones TL, Boeckers T, Rosenbrock H, von Arnim CAF. Exp Neurol. 2018 Jun;304:1-13. doi: 10.1016/j.expneurol.2018.02.010. Epub 2018 Feb 18. PubMed |
| Epstein-Barr Virus Nuclear Antigen Leader Protein Coactivates EP300. Wang C, Zhou H, Xue Y, Liang J, Narita Y, Gerdt C, Zheng AY, Jiang R, Trudeau S, Peng CW, Gewurz BE, Zhao B. J Virol. 2018 Apr 13;92(9). pii: JVI.02155-17. doi: 10.1128/JVI.02155-17. Print 2018 May 1. PubMed |
| A translational silencing function of MCPIP1/Regnase-1 specified by the target site context. Behrens G, Winzen R, Rehage N, Dorrie A, Barsch M, Hoffmann A, Hackermuller J, Tiedje C, Heissmeyer V, Holtmann H. Nucleic Acids Res. 2018 May 4;46(8):4256-4270. doi: 10.1093/nar/gky106. PubMed |
| Knockdown of Human AMPK Using the CRISPR/Cas9 Genome-Editing System. Grenier A, Sujobert P, Olivier S, Guermouche H, Mondesir J, Kosmider O, Viollet B, Tamburini J. Methods Mol Biol. 2018;1732:171-194. doi: 10.1007/978-1-4939-7598-3_11. PubMed |
| SMARCB1 Deficiency Integrates Epigenetic Signals to Oncogenic Gene Expression Program Maintenance in Human Acute Myeloid Leukemia. Chatterjee SS, Biswas M, Boila LD, Banerjee D, Sengupta A. Mol Cancer Res. 2018 May;16(5):791-804. doi: 10.1158/1541-7786.MCR-17-0493. Epub 2018 Feb 26. PubMed |
| The Histone Variant MacroH2A Blocks Cellular Reprogramming by Inhibiting Mesenchymal-to-Epithelial Transition. Pliatska M, Kapasa M, Kokkalis A, Polyzos A, Thanos D. Mol Cell Biol. 2018 Apr 30;38(10). pii: MCB.00669-17. doi: 10.1128/MCB.00669-17. Print 2018 May 15. PubMed |
| Fatty Acid Synthase induced S6Kinase facilitates USP11-eIF4B complex formation for sustained oncogenic translation in DLBCL. Kapadia B, Nanaji NM, Bhalla K, Bhandary B, Lapidus R, Beheshti A, Evens AM, Gartenhaus RB. Nat Commun. 2018 Feb 26;9(1):829. doi: 10.1038/s41467-018-03028-y. PubMed |
| Screening, large-scale production and structure-based classification of cystine-dense peptides. Correnti CE, Gewe MM, Mehlin C, Bandaranayake AD, Johnsen WA, Rupert PB, Brusniak MY, Clarke M, Burke SE, De Van Der Schueren W, Pilat K, Turnbaugh SM, May D, Watson A, Chan MK, Bahl CD, Olson JM, Strong RK. Nat Struct Mol Biol. 2018 Mar;25(3):270-278. doi: 10.1038/s41594-018-0033-9. Epub 2018 Feb 26. PubMed |
| Identification of interactions among host and bacterial proteins and evaluation of their role early during Shigella flexneri infection. Miller KA, Garza-Mayers AC, Leung Y, Goldberg MB. Microbiology. 2018 Apr;164(4):540-550. doi: 10.1099/mic.0.000637. Epub 2018 Feb 28. PubMed |
| ERK1/2 activated PHLPP1 induces skeletal muscle ER stress through the inhibition of a novel substrate AMPK. Behera S, Kapadia B, Kain V, Alamuru-Yellapragada NP, Murunikkara V, Kumar ST, Babu PP, Seshadri S, Shivarudraiah P, Hiriyan J, Gangula NR, Maddika S, Misra P, Parsa KVL. Biochim Biophys Acta Mol Basis Dis. 2018 May;1864(5 Pt A):1702-1716. doi: 10.1016/j.bbadis.2018.02.019. Epub 2018 Feb 27. PubMed |
| Enhanced insulin receptor, but not PI3K, signalling protects podocytes from ER stress. Garner KL, Betin VMS, Pinto V, Graham M, Abgueguen E, Barnes M, Bedford DC, McArdle CA, Coward RJM. Sci Rep. 2018 Mar 2;8(1):3902. doi: 10.1038/s41598-018-22233-9. PubMed |
| Novel RNA-Affinity Proteogenomics Dissects Tumor Heterogeneity for Revealing Personalized Markers in Precision Prognosis of Cancer. Wang L, Wrobel JA, Xie L, Li D, Zurlo G, Shen H, Yang P, Wang Z, Peng Y, Gunawardena HP, Zhang Q, Chen X. Cell Chem Biol. 2018 May 17;25(5):619-633.e5. doi: 10.1016/j.chembiol.2018.01.016. Epub 2018 Mar 1. PubMed |
| Functional TRIM24 degrader via conjugation of ineffectual bromodomain and VHL ligands. Gechijian LN, Buckley DL, Lawlor MA, Reyes JM, Paulk J, Ott CJ, Winter GE, Erb MA, Scott TG, Xu M, Seo HS, Dhe-Paganon S, Kwiatkowski NP, Perry JA, Qi J, Gray NS, Bradner JE. Nat Chem Biol. 2018 Apr;14(4):405-412. doi: 10.1038/s41589-018-0010-y. Epub 2018 Mar 5. PubMed |
| FLT3-ITD induces expression of Pim kinases through STAT5 to confer resistance to the PI3K/Akt pathway inhibitors on leukemic cells by enhancing the mTORC1/Mcl-1 pathway. Okada K, Nogami A, Ishida S, Akiyama H, Chen C, Umezawa Y, Miura O. Oncotarget. 2017 Dec 4;9(10):8870-8886. doi: 10.18632/oncotarget.22926. eCollection 2018 Feb 6. PubMed |
| Site-specific glycosylation regulates the form and function of the intermediate filament cytoskeleton. Tarbet HJ, Dolat L, Smith TJ, Condon BM, O'Brien ET 3rd, Valdivia RH, Boyce M. Elife. 2018 Mar 7;7. pii: 31807. doi: 10.7554/eLife.31807. PubMed |
| Porcine MKRN1 Modulates the Replication and Pathogenesis of Porcine Circovirus Type 2 by Inducing Capsid Protein Ubiquitination and Degradation. Wang T, Du Q, Wu X, Niu Y, Guan L, Wang Z, Zhao X, Liu SL, Tong D, Huang Y. J Virol. 2018 May 14;92(11). pii: JVI.00100-18. doi: 10.1128/JVI.00100-18. Print 2018 Jun 1. PubMed |
| Interferon-gamma converts human microvascular pericytes into negative regulators of alloimmunity through induction of indoleamine 2,3-dioxygenase 1. Liu R, Merola J, Manes TD, Qin L, Tietjen GT, Lopez-Giraldez F, Broecker V, Fang C, Xie C, Chen PM, Kirkiles-Smith NC, Jane-Wit D, Pober JS. JCI Insight. 2018 Mar 8;3(5). pii: 97881. doi: 10.1172/jci.insight.97881. PubMed |
| The convergent roles of NF-kappaB and ER stress in sunitinib-mediated expression of pro-tumorigenic cytokines and refractory phenotype in renal cell carcinoma. Makhov P, Naito S, Haifler M, Kutikov A, Boumber Y, Uzzo RG, Kolenko VM. Cell Death Dis. 2018 Mar 7;9(3):374. doi: 10.1038/s41419-018-0388-1. PubMed |
| Tau Phosphorylation is Impacted by Rare AKAP9 Mutations Associated with Alzheimer Disease in African Americans. Ikezu T, Chen C, DeLeo AM, Zeldich E, Fallin MD, Kanaan NM, Lunetta KL, Abraham CR, Logue MW, Farrer LA. J Neuroimmune Pharmacol. 2018 Jun;13(2):254-264. doi: 10.1007/s11481-018-9781-x. Epub 2018 Mar 7. PubMed |
| The oxidized phospholipid oxPAPC protects from septic shock by targeting the non-canonical inflammasome in macrophages. Chu LH, Indramohan M, Ratsimandresy RA, Gangopadhyay A, Morris EP, Monack DM, Dorfleutner A, Stehlik C. Nat Commun. 2018 Mar 8;9(1):996. doi: 10.1038/s41467-018-03409-3. PubMed |
| Overexpression of the base excision repair NTHL1 glycosylase causes genomic instability and early cellular hallmarks of cancer. Limpose KL, Trego KS, Li Z, Leung SW, Sarker AH, Shah JA, Ramalingam SS, Werner EM, Dynan WS, Cooper PK, Corbett AH, Doetsch PW. Nucleic Acids Res. 2018 May 18;46(9):4515-4532. doi: 10.1093/nar/gky162. PubMed |
| A type III complement factor D deficiency: Structural insights for inhibition of the alternative pathway. Sng CCT, O'Byrne S, Prigozhin DM, Bauer MR, Harvey JC, Ruhle M, Challis BG, Lear S, Roberts LD, Workman S, Janowitz T, Magiera L, Doffinger R, Buckland MS, Jodrell DJ, Semple RK, Wilson TJ, Modis Y, Thaventhiran JED. J Allergy Clin Immunol. 2018 Jul;142(1):311-314.e6. doi: 10.1016/j.jaci.2018.01.048. Epub 2018 Mar 6. PubMed |
Establishment of Cell Lines Stably Expressing dCas9-Fusions to Address Kinetics of Epigenetic Editing.
Goubert D, Koncz M, Kiss A, Rots MG.
Methods Mol Biol. 2018;1767:395-415. doi: 10.1007/978-1-4939-7774-1_22.
PubMed
Associated Plasmids |
| Screening Regulatory Element Function with CRISPR/Cas9-based Epigenome Editing. Klann TS, Crawford GE, Reddy TE, Gersbach CA. Methods Mol Biol. 2018;1767:447-480. doi: 10.1007/978-1-4939-7774-1_25. PubMed |
| Human IFIT3 Modulates IFIT1 RNA Binding Specificity and Protein Stability. Johnson B, VanBlargan LA, Xu W, White JP, Shan C, Shi PY, Zhang R, Adhikari J, Gross ML, Leung DW, Diamond MS, Amarasinghe GK. Immunity. 2018 Mar 20;48(3):487-499.e5. doi: 10.1016/j.immuni.2018.01.014. Epub 2018 Mar 8. PubMed |
LKB1, Salt-Inducible Kinases, and MEF2C Are Linked Dependencies in Acute Myeloid Leukemia.
Tarumoto Y, Lu B, Somerville TDD, Huang YH, Milazzo JP, Wu XS, Klingbeil O, El Demerdash O, Shi J, Vakoc CR.
Mol Cell. 2018 Feb 28. pii: S1097-2765(18)30109-6. doi: 10.1016/j.molcel.2018.02.011.
PubMed
Associated Plasmids |
| Insulin resistance causes inflammation in adipose tissue. Shimobayashi M, Albert V, Woelnerhanssen B, Frei IC, Weissenberger D, Meyer-Gerspach AC, Clement N, Moes S, Colombi M, Meier JA, Swierczynska MM, Jeno P, Beglinger C, Peterli R, Hall MN. J Clin Invest. 2018 Apr 2;128(4):1538-1550. doi: 10.1172/JCI96139. Epub 2018 Mar 12. PubMed |
NuRD and CAF-1-mediated silencing of the D4Z4 array is modulated by DUX4-induced MBD3L proteins.
Campbell AE, Shadle SC, Jagannathan S, Lim JW, Resnick R, Tawil R, van der Maarel SM, Tapscott SJ.
Elife. 2018 Mar 13;7. pii: 31023. doi: 10.7554/eLife.31023.
PubMed
Associated Plasmids |
| PKM1 Confers Metabolic Advantages and Promotes Cell-Autonomous Tumor Cell Growth. Morita M, Sato T, Nomura M, Sakamoto Y, Inoue Y, Tanaka R, Ito S, Kurosawa K, Yamaguchi K, Sugiura Y, Takizaki H, Yamashita Y, Katakura R, Sato I, Kawai M, Okada Y, Watanabe H, Kondoh G, Matsumoto S, Kishimoto A, Obata M, Matsumoto M, Fukuhara T, Motohashi H, Suematsu M, Komatsu M, Nakayama KI, Watanabe T, Soga T, Shima H, Maemondo M, Tanuma N. Cancer Cell. 2018 Mar 12;33(3):355-367.e7. doi: 10.1016/j.ccell.2018.02.004. PubMed |
| GATA3 zinc finger 2 mutations reprogram the breast cancer transcriptional network. Takaku M, Grimm SA, Roberts JD, Chrysovergis K, Bennett BD, Myers P, Perera L, Tucker CJ, Perou CM, Wade PA. Nat Commun. 2018 Mar 13;9(1):1059. doi: 10.1038/s41467-018-03478-4. PubMed |
| Rac1/WAVE2 and Cdc42/N-WASP Participation in Actin-Dependent Host Cell Invasion by Extracellular Amastigotes of Trypanosoma cruzi. Bonfim-Melo A, Ferreira ER, Mortara RA. Front Microbiol. 2018 Feb 28;9:360. doi: 10.3389/fmicb.2018.00360. eCollection 2018. PubMed |
| High Mobility Group Box 1 Influences HSV1716 Spread and Acts as an Adjuvant to Chemotherapy. Sprague L, Lee JM, Hutzen BJ, Wang PY, Chen CY, Conner J, Braidwood L, Cassady KA, Cripe TP. Viruses. 2018 Mar 15;10(3). pii: v10030132. doi: 10.3390/v10030132. PubMed |
| Reshaping of the Dendritic Cell Chromatin Landscape and Interferon Pathways during HIV Infection. Johnson JS, Lucas SY, Amon LM, Skelton S, Nazitto R, Carbonetti S, Sather DN, Littman DR, Aderem A. Cell Host Microbe. 2018 Mar 14;23(3):366-381.e9. doi: 10.1016/j.chom.2018.01.012. PubMed |
| MicroRNA-181c promotes Th17 cell differentiation and mediates experimental autoimmune encephalomyelitis. Zhang Z, Xue Z, Liu Y, Liu H, Guo X, Li Y, Yang H, Zhang L, Da Y, Yao Z, Zhang R. Brain Behav Immun. 2018 May;70:305-314. doi: 10.1016/j.bbi.2018.03.011. Epub 2018 Mar 12. PubMed |
| Lentiviral Transduction of Rat Schwann Cells and Dorsal Root Ganglia Neurons for In Vitro Myelination Studies. Heffernan C, Maurel P. Methods Mol Biol. 2018;1739:177-193. doi: 10.1007/978-1-4939-7649-2_12. PubMed |
| Multi-color fluorescent reporter dengue viruses with improved stability for analysis of a multi-virus infection. Suphatrakul A, Duangchinda T, Jupatanakul N, Prasittisa K, Onnome S, Pengon J, Siridechadilok B. PLoS One. 2018 Mar 16;13(3):e0194399. doi: 10.1371/journal.pone.0194399. eCollection 2018. PubMed |
| DNA Conformation Induces Adaptable Binding by Tandem Zinc Finger Proteins. Patel A, Yang P, Tinkham M, Pradhan M, Sun MA, Wang Y, Hoang D, Wolf G, Horton JR, Zhang X, Macfarlan T, Cheng X. Cell. 2018 Mar 22;173(1):221-233.e12. doi: 10.1016/j.cell.2018.02.058. Epub 2018 Mar 15. PubMed |
Transcriptome Engineering with RNA-Targeting Type VI-D CRISPR Effectors.
Konermann S, Lotfy P, Brideau NJ, Oki J, Shokhirev MN, Hsu PD.
Cell. 2018 Mar 8. pii: S0092-8674(18)30207-1. doi: 10.1016/j.cell.2018.02.033.
PubMed
Associated Plasmids |
Coordinated Activity of Y Family TLS Polymerases and EXO1 Protects Non-S Phase Cells from UV-Induced Cytotoxic Lesions.
Sertic S, Mollica A, Campus I, Roma S, Tumini E, Aguilera A, Muzi-Falconi M.
Mol Cell. 2018 Apr 5;70(1):34-47.e4. doi: 10.1016/j.molcel.2018.02.017. Epub 2018 Mar 15.
PubMed
Associated Plasmids |
| High Throughput NPY-Venus and Serotonin Secretion Assays for Regulated Exocytosis in Neuroendocrine Cells. Zhang XA, Martin TFJ. Bio Protoc. 2018 Jan 5;8(1). doi: 10.21769/BioProtoc.2680. PubMed |
| Pooled shRNA Screen for Reactivation of MeCP2 on the Inactive X Chromosome. Leko V, Sripathy S, Adrianse RL, Loe T, Park A, Lao U, Foss EJ, Bartolomei MS, Bedalov A. J Vis Exp. 2018 Mar 2;(133). doi: 10.3791/56398. PubMed |
A CRISPR screen for factors regulating SAMHD1 degradation identifies IFITMs as potent inhibitors of lentiviral particle delivery.
Roesch F, OhAinle M, Emerman M.
Retrovirology. 2018 Mar 20;15(1):26. doi: 10.1186/s12977-018-0409-2.
PubMed
Associated Plasmids |
| p23 protects the human aryl hydrocarbon receptor from degradation via a heat shock protein 90-independent mechanism. Pappas B, Yang Y, Wang Y, Kim K, Chung HJ, Cheung M, Ngo K, Shinn A, Chan WK. Biochem Pharmacol. 2018 Jun;152:34-44. doi: 10.1016/j.bcp.2018.03.015. Epub 2018 Mar 17. PubMed |
| Expression of Carbonic Anhydrase III, a Nucleus Pulposus Phenotypic Marker, is Hypoxia-responsive and Confers Protection from Oxidative Stress-induced Cell Death. Silagi ES, Batista P, Shapiro IM, Risbud MV. Sci Rep. 2018 Mar 20;8(1):4856. doi: 10.1038/s41598-018-23196-7. PubMed |
| GATA1s exerts developmental stage-specific effects in human hematopoiesis. Gialesaki S, Mahnken AK, Schmid L, Labuhn M, Bhayadia R, Heckl D, Klusmann JH. Haematologica. 2018 Aug;103(8):e336-e340. doi: 10.3324/haematol.2018.191338. Epub 2018 Mar 22. PubMed |
| Impairment of an Endothelial NAD(+)-H2S Signaling Network Is a Reversible Cause of Vascular Aging. Das A, Huang GX, Bonkowski MS, Longchamp A, Li C, Schultz MB, Kim LJ, Osborne B, Joshi S, Lu Y, Trevino-Villarreal JH, Kang MJ, Hung TT, Lee B, Williams EO, Igarashi M, Mitchell JR, Wu LE, Turner N, Arany Z, Guarente L, Sinclair DA. Cell. 2018 Mar 22;173(1):74-89.e20. doi: 10.1016/j.cell.2018.02.008. PubMed |
Expression of a Constitutively Active Human Insulin Receptor in Hippocampal Neurons Does Not Alter VGCC Currents.
Frazier HN, Anderson KL, Maimaiti S, Ghoweri AO, Kraner SD, Popa GJ, Hampton KK, Mendenhall MD, Norris CM, Craven RJ, Thibault O.
Neurochem Res. 2019 Jan;44(1):269-280. doi: 10.1007/s11064-018-2510-2. Epub 2018 Mar 23.
PubMed
Associated Plasmids |
| MicroRNA-499a-5p Promotes Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells to Cardiomyocytes. Neshati V, Mollazadeh S, Fazly Bazzaz BS, de Vries AAF, Mojarrad M, Naderi-Meshkin H, Neshati Z, Mirahmadi M, Kerachian MA. Appl Biochem Biotechnol. 2018 Sep;186(1):245-255. doi: 10.1007/s12010-018-2734-2. Epub 2018 Mar 24. PubMed |
| Profound Tissue Specificity in Proliferation Control Underlies Cancer Drivers and Aneuploidy Patterns. Sack LM, Davoli T, Li MZ, Li Y, Xu Q, Naxerova K, Wooten EC, Bernardi RJ, Martin TD, Chen T, Leng Y, Liang AC, Scorsone KA, Westbrook TF, Wong KK, Elledge SJ. Cell. 2018 Apr 5;173(2):499-514.e23. doi: 10.1016/j.cell.2018.02.037. Epub 2018 Mar 22. PubMed |
| Remote Control of Mammalian Cells with Heat-Triggered Gene Switches and Photothermal Pulse Trains. Miller IC, Gamboa Castro M, Maenza J, Weis JP, Kwong GA. ACS Synth Biol. 2018 Apr 20;7(4):1167-1173. doi: 10.1021/acssynbio.7b00455. Epub 2018 Apr 10. PubMed |
| Molecular cloning, expression, and characterization of UDP N-acetyl-alpha-d-galactosamine: Polypeptide N-acetylgalactosaminyltransferase 4 from Cryptosporidium parvum. DeCicco RePass MA, Bhat N, Heimburg-Molinaro J, Bunnell S, Cummings RD, Ward HD. Mol Biochem Parasitol. 2018 Apr;221:56-65. doi: 10.1016/j.molbiopara.2018.03.002. Epub 2018 Mar 23. PubMed |
| ER-positive breast cancer cells are poised for RET-mediated endocrine resistance. Horibata S, Rice EJ, Mukai C, Marks BA, Sams K, Zheng H, Anguish LJ, Coonrod SA, Danko CG. PLoS One. 2018 Apr 2;13(4):e0194023. doi: 10.1371/journal.pone.0194023. eCollection 2018. PubMed |
| Induction, regulation and roles of neural adhesion molecule L1CAM in cellular senescence. Mrazkova B, Dzijak R, Imrichova T, Kyjacova L, Barath P, Dzubak P, Holub D, Hajduch M, Nahacka Z, Andera L, Holicek P, Vasicova P, Sapega O, Bartek J, Hodny Z. Aging (Albany NY). 2018 Mar 28;10(3):434-462. doi: 10.18632/aging.101404. PubMed |
| Genetic abrogation of immune checkpoints in antigen-specific cytotoxic T-lymphocyte as a potential alternative to blockade immunotherapy. Zhang C, Peng Y, Hublitz P, Zhang H, Dong T. Sci Rep. 2018 Apr 3;8(1):5549. doi: 10.1038/s41598-018-23803-7. PubMed |
| Metabolic enzyme PFKFB4 activates transcriptional coactivator SRC-3 to drive breast cancer. Dasgupta S, Rajapakshe K, Zhu B, Nikolai BC, Yi P, Putluri N, Choi JM, Jung SY, Coarfa C, Westbrook TF, Zhang XH, Foulds CE, Tsai SY, Tsai MJ, O'Malley BW. Nature. 2018 Apr;556(7700):249-254. doi: 10.1038/s41586-018-0018-1. Epub 2018 Apr 3. PubMed |
| Molecular Characterization and Clinical Relevance of Metabolic Expression Subtypes in Human Cancers. Peng X, Chen Z, Farshidfar F, Xu X, Lorenzi PL, Wang Y, Cheng F, Tan L, Mojumdar K, Du D, Ge Z, Li J, Thomas GV, Birsoy K, Liu L, Zhang H, Zhao Z, Marchand C, Weinstein JN, Bathe OF, Liang H. Cell Rep. 2018 Apr 3;23(1):255-269.e4. doi: 10.1016/j.celrep.2018.03.077. PubMed |
| Autophagy regulates testosterone synthesis by facilitating cholesterol uptake in Leydig cells. Gao F, Li G, Liu C, Gao H, Wang H, Liu W, Chen M, Shang Y, Wang L, Shi J, Xia W, Jiao J, Gao F, Li J, Chen L, Li W. J Cell Biol. 2018 Jun 4;217(6):2103-2119. doi: 10.1083/jcb.201710078. Epub 2018 Apr 4. PubMed |
| Decreased expression of SFRP2 promotes development of the pituitary corticotroph adenoma by upregulating Wnt signaling. Ren J, Jian F, Jiang H, Sun Y, Pan S, Gu C, Chen X, Wang W, Ning G, Bian L, Sun Q. Int J Oncol. 2018 Jun;52(6):1934-1946. doi: 10.3892/ijo.2018.4355. Epub 2018 Apr 3. PubMed |
| Impact of Nrf2 on tumour growth and drug sensitivity in oncogenic K-ras-transformed cells in vitro and in vivo. Shao J, Glorieux C, Liao J, Chen P, Lu W, Liang Z, Wen S, Hu Y, Huang P. Free Radic Res. 2018 Jun;52(6):661-671. doi: 10.1080/10715762.2018.1462494. Epub 2018 May 3. PubMed |
| lncRNA Epigenetic Landscape Analysis Identifies EPIC1 as an Oncogenic lncRNA that Interacts with MYC and Promotes Cell-Cycle Progression in Cancer. Wang Z, Yang B, Zhang M, Guo W, Wu Z, Wang Y, Jia L, Li S, Xie W, Yang D. Cancer Cell. 2018 Apr 9;33(4):706-720.e9. doi: 10.1016/j.ccell.2018.03.006. Epub 2018 Apr 2. PubMed |
| The YAP/TAZ transcriptional co-activators have opposing effects at different stages of osteoblast differentiation. Xiong J, Almeida M, O'Brien CA. Bone. 2018 Jul;112:1-9. doi: 10.1016/j.bone.2018.04.001. Epub 2018 Apr 4. PubMed |
| Cardiomyogenic differentiation of human adipose-derived mesenchymal stem cells transduced with Tbx20-encoding lentiviral vectors. Neshati V, Mollazadeh S, Fazly Bazzaz BS, de Vries AA, Mojarrad M, Naderi-Meshkin H, Neshati Z, Kerachian MA. J Cell Biochem. 2018 Jul;119(7):6146-6153. doi: 10.1002/jcb.26818. Epub 2018 Apr 10. PubMed |
| The Forkhead Transcription Factor FOXC2 Is Required for Maintaining Murine Spermatogonial Stem Cells. Wei C, Lin H, Cui S. Stem Cells Dev. 2018 May 1;27(9):624-636. doi: 10.1089/scd.2017.0233. Epub 2018 Apr 26. PubMed |
| Single HIV-1 Imaging Reveals Progression of Infection through CA-Dependent Steps of Docking at the Nuclear Pore, Uncoating, and Nuclear Transport. Francis AC, Melikyan GB. Cell Host Microbe. 2018 Apr 11;23(4):536-548.e6. doi: 10.1016/j.chom.2018.03.009. PubMed |
| AKAPs-PKA disruptors increase AQP2 activity independently of vasopressin in a model of nephrogenic diabetes insipidus. Ando F, Mori S, Yui N, Morimoto T, Nomura N, Sohara E, Rai T, Sasaki S, Kondo Y, Kagechika H, Uchida S. Nat Commun. 2018 Apr 12;9(1):1411. doi: 10.1038/s41467-018-03771-2. PubMed |
| Integrated design, execution, and analysis of arrayed and pooled CRISPR genome-editing experiments. Canver MC, Haeussler M, Bauer DE, Orkin SH, Sanjana NE, Shalem O, Yuan GC, Zhang F, Concordet JP, Pinello L. Nat Protoc. 2018 May;13(5):946-986. doi: 10.1038/nprot.2018.005. Epub 2018 Apr 12. PubMed |
| CD10 inhibits cell motility but expression is associated with advanced stage disease in colorectal cancer. Raposo TP, Comes MS, Idowu A, Agit B, Hassall J, Fadhil W, Nica R, Ecker R, Yao T, Ilyas M. Exp Mol Pathol. 2018 Jun;104(3):190-198. doi: 10.1016/j.yexmp.2018.04.002. Epub 2018 Apr 11. PubMed |
| Nucleic acid-induced potentiation of matrix metalloproteinase-9 enzymatic activity. Duellman T, Chen X, Wakamiya R, Yang J. Biochem J. 2018 May 9;475(9):1597-1610. doi: 10.1042/BCJ20180035. PubMed |
| hTERT gene knockdown enhances response to radio- and chemotherapy in head and neck cancer cell lines through a DNA damage pathway modification. Barczak W, Sobecka A, Golusinski P, Masternak MM, Rubis B, Suchorska WM, Golusinski W. Sci Rep. 2018 Apr 13;8(1):5949. doi: 10.1038/s41598-018-24503-y. PubMed |
| Metformin alleviates human cellular aging by upregulating the endoplasmic reticulum glutathione peroxidase 7. Fang J, Yang J, Wu X, Zhang G, Li T, Wang X, Zhang H, Wang CC, Liu GH, Wang L. Aging Cell. 2018 Apr 16:e12765. doi: 10.1111/acel.12765. PubMed |
| ARID1A ablation leads to multiple drug resistance in ovarian cancer via transcriptional activation of MRP2. Luo Q, Wu X, Zhang Y, Shu T, Ding F, Chen H, Zhao P, Chang W, Zhu X, Liu Z. Cancer Lett. 2018 Jul 28;427:9-17. doi: 10.1016/j.canlet.2018.04.013. Epub 2018 Apr 13. PubMed |
| lincRNA-Cox2 regulates NLRP3 inflammasome and autophagy mediated neuroinflammation. Xue Z, Zhang Z, Liu H, Li W, Guo X, Zhang Z, Liu Y, Jia L, Li Y, Ren Y, Yang H, Zhang L, Zhang Q, Da Y, Hao J, Yao Z, Zhang R. Cell Death Differ. 2019 Jan;26(1):130-145. doi: 10.1038/s41418-018-0105-8. Epub 2018 Apr 17. PubMed |
| Electrophilic properties of itaconate and derivatives regulate the IkappaBzeta-ATF3 inflammatory axis. Bambouskova M, Gorvel L, Lampropoulou V, Sergushichev A, Loginicheva E, Johnson K, Korenfeld D, Mathyer ME, Kim H, Huang LH, Duncan D, Bregman H, Keskin A, Santeford A, Apte RS, Sehgal R, Johnson B, Amarasinghe GK, Soares MP, Satoh T, Akira S, Hai T, de Guzman Strong C, Auclair K, Roddy TP, Biller SA, Jovanovic M, Klechevsky E, Stewart KM, Randolph GJ, Artyomov MN. Nature. 2018 Apr;556(7702):501-504. doi: 10.1038/s41586-018-0052-z. Epub 2018 Apr 18. PubMed |
| Methylation-induced silencing of SPG20 facilitates gastric cancer cell proliferation by activating the EGFR/MAPK pathway. Zhou Z, Wang W, Xie X, Song Y, Dang C, Zhang H. Biochem Biophys Res Commun. 2018 Jun 2;500(2):411-417. doi: 10.1016/j.bbrc.2018.04.089. Epub 2018 Apr 18. PubMed |
| An Integrated Genome-wide CRISPRa Approach to Functionalize lncRNAs in Drug Resistance. Bester AC, Lee JD, Chavez A, Lee YR, Nachmani D, Vora S, Victor J, Sauvageau M, Monteleone E, Rinn JL, Provero P, Church GM, Clohessy JG, Pandolfi PP. Cell. 2018 Apr 19;173(3):649-664.e20. doi: 10.1016/j.cell.2018.03.052. PubMed |
| RNA Binding Protein, HuR, Regulates SCN5A Expression Through Stabilizing MEF2C transcription factor mRNA. Zhou A, Shi G, Kang GJ, Xie A, Liu H, Jiang N, Liu M, Jeong EM, Dudley SC Jr. J Am Heart Assoc. 2018 Apr 20;7(9). pii: JAHA.117.007802. doi: 10.1161/JAHA.117.007802. PubMed |
| 14-3-3 proteins regulate desmosomal adhesion via plakophilins. Rietscher K, Keil R, Jordan A, Hatzfeld M. J Cell Sci. 2018 May 22;131(10). pii: jcs.212191. doi: 10.1242/jcs.212191. PubMed |
| Targeting GLP-1 receptor trafficking to improve agonist efficacy. Jones B, Buenaventura T, Kanda N, Chabosseau P, Owen BM, Scott R, Goldin R, Angkathunyakul N, Correa IR Jr, Bosco D, Johnson PR, Piemonti L, Marchetti P, Shapiro AMJ, Cochran BJ, Hanyaloglu AC, Inoue A, Tan T, Rutter GA, Tomas A, Bloom SR. Nat Commun. 2018 Apr 23;9(1):1602. doi: 10.1038/s41467-018-03941-2. PubMed |
| Pharmacological versus genetic inhibition of heme oxygenase-1 - the comparison of metalloporphyrins, shRNA and CRISPR/Cas9 system. Mucha O, Podkalicka P, Czarnek M, Biela A, Mieczkowski M, Kachamakova-Trojanowska N, Stepniewski J, Jozkowicz A, Dulak J, Loboda A. Acta Biochim Pol. 2018;65(2):277-286. doi: 10.18388/abp.2017_2542. Epub 2018 Apr 25. PubMed |
| A High-Content Screening of Anticancer Compounds Suggests the Multiple Tyrosine Kinase Inhibitor Ponatinib for Repurposing in Neuroblastoma Therapy. Sidarovich V, De Mariano M, Aveic S, Pancher M, Adami V, Gatto P, Pizzini S, Pasini L, Croce M, Parodi F, Cimmino F, Avitabile M, Emionite L, Cilli M, Ferrini S, Pagano A, Capasso M, Quattrone A, Tonini GP, Longo L. Mol Cancer Ther. 2018 Jul;17(7):1405-1415. doi: 10.1158/1535-7163.MCT-17-0841. Epub 2018 Apr 25. PubMed |
| Regulation of calretinin in malignant mesothelioma is mediated by septin 7 binding to the CALB2 promoter. Blum W, Pecze L, Rodriguez JW, Steinauer M, Schwaller B. BMC Cancer. 2018 Apr 27;18(1):475. doi: 10.1186/s12885-018-4385-7. PubMed |
| RhoA, Rac1, and Cdc42 differentially regulate alphaSMA and collagen I expression in mesenchymal stem cells. Ge J, Burnier L, Adamopoulou M, Kwa MQ, Schaks M, Rottner K, Brakebusch C. J Biol Chem. 2018 Jun 15;293(24):9358-9369. doi: 10.1074/jbc.RA117.001113. Epub 2018 Apr 26. PubMed |
RNA-guided transcriptional silencing in vivo with S. aureus CRISPR-Cas9 repressors.
Thakore PI, Kwon JB, Nelson CE, Rouse DC, Gemberling MP, Oliver ML, Gersbach CA.
Nat Commun. 2018 Apr 26;9(1):1674. doi: 10.1038/s41467-018-04048-4.
PubMed
Associated Plasmids |
| Endometrial Mesenchymal Stem/Stromal Cells Modulate the Macrophage Response to Implanted Polyamide/Gelatin Composite Mesh in Immunocompromised and Immunocompetent Mice. Darzi S, Deane JA, Nold CA, Edwards SE, Gough DJ, Mukherjee S, Gurung S, Tan KS, Vashi AV, Werkmeister JA, Gargett CE. Sci Rep. 2018 Apr 26;8(1):6554. doi: 10.1038/s41598-018-24919-6. PubMed |
| Cationic Polymer-Mediated CRISPR/Cas9 Plasmid Delivery for Genome Editing. Zhang Z, Wan T, Chen Y, Chen Y, Sun H, Cao T, Songyang Z, Tang G, Wu C, Ping Y, Xu FJ, Huang J. Macromol Rapid Commun. 2019 Mar;40(5):e1800068. doi: 10.1002/marc.201800068. Epub 2018 Apr 30. PubMed |
| A Comprehensive Procedure to Evaluate the In Vitro Performance of the Putative Hemangioblastoma Neovascularization Using the Spheroid Sprouting Assay. Wang Y, Chen D, Chen M, Ji K, Ma D, Zhou L. J Vis Exp. 2018 Apr 12;(134). doi: 10.3791/57183. PubMed |
| TRPV4 inhibition prevents paclitaxel-induced neurotoxicity in preclinical models. Boehmerle W, Huehnchen P, Lee SLL, Harms C, Endres M. Exp Neurol. 2018 Aug;306:64-75. doi: 10.1016/j.expneurol.2018.04.014. Epub 2018 Apr 30. PubMed |
| Posttranslational regulation of CYP2J2 by nitric oxide. Park JW, Lee CM, Cheng JS, Morgan ET. Free Radic Biol Med. 2018 Jun;121:149-156. doi: 10.1016/j.freeradbiomed.2018.04.576. Epub 2018 Apr 30. PubMed |
| Oncogene Lin28B increases chemosensitivity of colon cancer cells in a let-7-independent manner. Ma L, Zhao Q, Chen W, Zhang Y. Oncol Lett. 2018 May;15(5):6975-6981. doi: 10.3892/ol.2018.8250. Epub 2018 Mar 13. PubMed |
| PRC1 Fine-tunes Gene Repression and Activation to Safeguard Skin Development and Stem Cell Specification. Cohen I, Zhao D, Bar C, Valdes VJ, Dauber-Decker KL, Nguyen MB, Nakayama M, Rendl M, Bickmore WA, Koseki H, Zheng D, Ezhkova E. Cell Stem Cell. 2018 May 3;22(5):726-739.e7. doi: 10.1016/j.stem.2018.04.005. PubMed |
| RBM14 is indispensable for pluripotency maintenance and mesoderm development of mouse embryonic stem cells. Chen G, Zhang D, Zhang L, Feng G, Zhang B, Wu Y, Li W, Zhang Y, Hu B. Biochem Biophys Res Commun. 2018 Jun 18;501(1):259-265. doi: 10.1016/j.bbrc.2018.04.231. Epub 2018 May 8. PubMed |
| Differential regulation of the pro-inflammatory biomarker, YKL-40/CHI3L1, by PTEN/Phosphoinositide 3-kinase and JAK2/STAT3 pathways in glioblastoma. Wang Y, Wong CW, Yan M, Li L, Liu T, Or PM, Tsui SK, Waye MM, Chan AM. Cancer Lett. 2018 Aug 10;429:54-65. doi: 10.1016/j.canlet.2018.04.040. Epub 2018 May 3. PubMed |
| RNA Helicase DDX1 Converts RNA G-Quadruplex Structures into R-Loops to Promote IgH Class Switch Recombination. Ribeiro de Almeida C, Dhir S, Dhir A, Moghaddam AE, Sattentau Q, Meinhart A, Proudfoot NJ. Mol Cell. 2018 May 17;70(4):650-662.e8. doi: 10.1016/j.molcel.2018.04.001. Epub 2018 May 3. PubMed |
| Identification of the Intragenomic Promoter Controlling Hepatitis E Virus Subgenomic RNA Transcription. Ding Q, Nimgaonkar I, Archer NF, Bram Y, Heller B, Schwartz RE, Ploss A. MBio. 2018 May 8;9(3). pii: mBio.00769-18. doi: 10.1128/mBio.00769-18. PubMed |
| Inhibition of Tip60 Reduces Lytic and Latent Gene Expression of Kaposi's Sarcoma-Associated Herpes Virus (KSHV) and Proliferation of KSHV-Infected Tumor Cells. Simpson S, Fiches G, Jean MJ, Dieringer M, McGuinness J, John SP, Shamay M, Desai P, Zhu J, Santoso NG. Front Microbiol. 2018 Apr 24;9:788. doi: 10.3389/fmicb.2018.00788. eCollection 2018. PubMed |
| Identification of inhibitors synergizing gemcitabine sensitivity in the squamous subtype of pancreatic ductal adenocarcinoma (PDAC). Er JL, Goh PN, Lee CY, Tan YJ, Hii LW, Mai CW, Chung FF, Leong CO. Apoptosis. 2018 Jun;23(5-6):343-355. doi: 10.1007/s10495-018-1459-6. PubMed |
| Identification of a transporter complex responsible for the cytosolic entry of nitrogen-containing bisphosphonates. Yu Z, Surface LE, Park CY, Horlbeck MA, Wyant GA, Abu-Remaileh M, Peterson TR, Sabatini DM, Weissman JS, O'Shea EK. Elife. 2018 May 10;7. pii: 36620. doi: 10.7554/eLife.36620. PubMed |
| Metabolic regulation of transcription through compartmentalized NAD(+) biosynthesis. Ryu KW, Nandu T, Kim J, Challa S, DeBerardinis RJ, Kraus WL. Science. 2018 May 11;360(6389). pii: 360/6389/eaan5780. doi: 10.1126/science.aan5780. PubMed |
| Single molecule fate of HIV-1 envelope reveals late-stage viral lattice incorporation. Buttler CA, Pezeshkian N, Fernandez MV, Aaron J, Norman S, Freed EO, van Engelenburg SB. Nat Commun. 2018 May 10;9(1):1861. doi: 10.1038/s41467-018-04220-w. PubMed |
| TGF-beta induces miR-100 and miR-125b but blocks let-7a through LIN28B controlling PDAC progression. Ottaviani S, Stebbing J, Frampton AE, Zagorac S, Krell J, de Giorgio A, Trabulo SM, Nguyen VTM, Magnani L, Feng H, Giovannetti E, Funel N, Gress TM, Jiao LR, Lombardo Y, Lemoine NR, Heeschen C, Castellano L. Nat Commun. 2018 May 10;9(1):1845. doi: 10.1038/s41467-018-03962-x. PubMed |
| Specific targeting of point mutations in EGFR L858R-positive lung cancer by CRISPR/Cas9. Cheung AH, Chow C, Zhang J, Zhou Y, Huang T, Ng KC, Or TC, Yao YY, Dong Y, Fung JM, Xiong L, Chan AK, Lung WR, Kang W, To KF. Lab Invest. 2018 Jul;98(7):968-976. doi: 10.1038/s41374-018-0056-1. Epub 2018 May 10. PubMed |
| Generation of hepatocyte- and endocrine pancreatic-like cells from human induced endodermal progenitor cells. Sambathkumar R, Akkerman R, Dastidar S, Roelandt P, Kumar M, Bajaj M, Mestre Rosa AR, Helsen N, Vanslembrouck V, Kalo E, Khurana S, Laureys J, Gysemans C, Faas MM, de Vos P, Verfaillie CM. PLoS One. 2018 May 11;13(5):e0197046. doi: 10.1371/journal.pone.0197046. eCollection 2018. PubMed |
| Genetic Engineering of Mesenchymal Stem Cells for Differential Matrix Deposition on 3D Woven Scaffolds. Huynh NPT, Brunger JM, Gloss CC, Moutos FT, Gersbach CA, Guilak F. Tissue Eng Part A. 2018 Oct;24(19-20):1531-1544. doi: 10.1089/ten.TEA.2017.0510. Epub 2018 Jul 13. PubMed |
| Regulation of BDNF Release by ARMS/Kidins220 through Modulation of Synaptotagmin-IV Levels. Lopez-Benito S, Sanchez-Sanchez J, Brito V, Calvo L, Lisa S, Torres-Valle M, Palko ME, Vicente-Garcia C, Fernandez-Fernandez S, Bolanos JP, Gines S, Tessarollo L, Arevalo JC. J Neurosci. 2018 Jun 6;38(23):5415-5428. doi: 10.1523/JNEUROSCI.1653-17.2018. Epub 2018 May 16. PubMed |
| Mxra8 is a receptor for multiple arthritogenic alphaviruses. Zhang R, Kim AS, Fox JM, Nair S, Basore K, Klimstra WB, Rimkunas R, Fong RH, Lin H, Poddar S, Crowe JE Jr, Doranz BJ, Fremont DH, Diamond MS. Nature. 2018 May;557(7706):570-574. doi: 10.1038/s41586-018-0121-3. Epub 2018 May 16. PubMed |
| CRISPR/Cas9 system targeting regulatory genes of HIV-1 inhibits viral replication in infected T-cell cultures. Ophinni Y, Inoue M, Kotaki T, Kameoka M. Sci Rep. 2018 May 17;8(1):7784. doi: 10.1038/s41598-018-26190-1. PubMed |
| Caspase-3 Regulates YAP-Dependent Cell Proliferation and Organ Size. Yosefzon Y, Soteriou D, Feldman A, Kostic L, Koren E, Brown S, Ankawa R, Sedov E, Glaser F, Fuchs Y. Mol Cell. 2018 May 17;70(4):573-587.e4. doi: 10.1016/j.molcel.2018.04.019. PubMed |
| The Bicarbonate Transporter SLC4A7 Plays a Key Role in Macrophage Phagosome Acidification. Sedlyarov V, Eichner R, Girardi E, Essletzbichler P, Goldmann U, Nunes-Hasler P, Srndic I, Moskovskich A, Heinz LX, Kartnig F, Bigenzahn JW, Rebsamen M, Kovarik P, Demaurex N, Superti-Furga G. Cell Host Microbe. 2018 Jun 13;23(6):766-774.e5. doi: 10.1016/j.chom.2018.04.013. Epub 2018 May 17. PubMed |
| The NOTCH1/CD44 axis drives pathogenesis in a T cell acute lymphoblastic leukemia model. Garcia-Peydro M, Fuentes P, Mosquera M, Garcia-Leon MJ, Alcain J, Rodriguez A, Garcia de Miguel P, Menendez P, Weijer K, Spits H, Scadden DT, Cuesta-Mateos C, Munoz-Calleja C, Sanchez-Madrid F, Toribio ML. J Clin Invest. 2018 Jul 2;128(7):2802-2818. doi: 10.1172/JCI92981. Epub 2018 May 21. PubMed |
| Targeting the upstream transcriptional activator of PD-L1 as an alternative strategy in melanoma therapy. Zhu B, Tang L, Chen S, Yin C, Peng S, Li X, Liu T, Liu W, Han C, Stawski L, Xu ZX, Zhou G, Chen X, Gao X, Goding CR, Xu N, Cui R, Cao P. Oncogene. 2018 Sep;37(36):4941-4954. doi: 10.1038/s41388-018-0314-0. Epub 2018 May 22. PubMed |
| Super-resolution architecture of mammalian centriole distal appendages reveals distinct blade and matrix functional components. Yang TT, Chong WM, Wang WJ, Mazo G, Tanos B, Chen Z, Tran TMN, Chen YD, Weng RR, Huang CE, Jane WN, Tsou MB, Liao JC. Nat Commun. 2018 May 22;9(1):2023. doi: 10.1038/s41467-018-04469-1. PubMed |
| Targetable vulnerabilities in T- and NK-cell lymphomas identified through preclinical models. Ng SY, Yoshida N, Christie AL, Ghandi M, Dharia NV, Dempster J, Murakami M, Shigemori K, Morrow SN, Van Scoyk A, Cordero NA, Stevenson KE, Puligandla M, Haas B, Lo C, Meyers R, Gao G, Cherniack A, Louissaint A Jr, Nardi V, Thorner AR, Long H, Qiu X, Morgan EA, Dorfman DM, Fiore D, Jang J, Epstein AL, Dogan A, Zhang Y, Horwitz SM, Jacobsen ED, Santiago S, Ren JG, Guerlavais V, Annis DA, Aivado M, Saleh MN, Mehta A, Tsherniak A, Root D, Vazquez F, Hahn WC, Inghirami G, Aster JC, Weinstock DM, Koch R. Nat Commun. 2018 May 22;9(1):2024. doi: 10.1038/s41467-018-04356-9. PubMed |
| Uncoupling of sgRNAs from their associated barcodes during PCR amplification of combinatorial CRISPR screens. Hegde M, Strand C, Hanna RE, Doench JG. PLoS One. 2018 May 25;13(5):e0197547. doi: 10.1371/journal.pone.0197547. eCollection 2018. PubMed |
| Epigenetic reactivation of LINE-1 retrotransposon disrupts NuRD corepressor functions and induces oncogenic transformation in human bronchial epithelial cells. Bojang P Jr, Ramos KS. Mol Oncol. 2018 Aug;12(8):1342-1357. doi: 10.1002/1878-0261.12329. Epub 2018 Jun 21. PubMed |
| IP6 is an HIV pocket factor that prevents capsid collapse and promotes DNA synthesis. Mallery DL, Marquez CL, McEwan WA, Dickson CF, Jacques DA, Anandapadamanaban M, Bichel K, Towers GJ, Saiardi A, Bocking T, James LC. Elife. 2018 May 31;7. pii: 35335. doi: 10.7554/eLife.35335. PubMed |
| Smc5/6 Antagonism by HBx Is an Evolutionarily Conserved Function of Hepatitis B Virus Infection in Mammals. Abdul F, Filleton F, Gerossier L, Paturel A, Hall J, Strubin M, Etienne L. J Virol. 2018 Jul 31;92(16). pii: JVI.00769-18. doi: 10.1128/JVI.00769-18. Print 2018 Aug 15. PubMed |
| Partial Inactivation of the Chromatin Remodelers SMARCA2 and SMARCA4 in Virus-Infected Cells by Caspase-Mediated Cleavage. Dudek AH, Pfaff F, Bolte H, Waguia Kontchou C, Schwemmle M. J Virol. 2018 Jul 31;92(16). pii: JVI.00343-18. doi: 10.1128/JVI.00343-18. Print 2018 Aug 15. PubMed |
| CRISPR/Cas9 Genome Editing of Epidermal Growth Factor Receptor Sufficiently Abolished Oncogenicity in Anaplastic Thyroid Cancer. Huang LC, Tam KW, Liu WN, Lin CY, Hsu KW, Hsieh WS, Chi WM, Lee AW, Yang JM, Lin CL, Lee CH. Dis Markers. 2018 Apr 12;2018:3835783. doi: 10.1155/2018/3835783. eCollection 2018. PubMed |
Human-Specific NOTCH2NL Genes Expand Cortical Neurogenesis through Delta/Notch Regulation.
Suzuki IK, Gacquer D, Van Heurck R, Kumar D, Wojno M, Bilheu A, Herpoel A, Lambert N, Cheron J, Polleux F, Detours V, Vanderhaeghen P.
Cell. 2018 May 31;173(6):1370-1384.e16. doi: 10.1016/j.cell.2018.03.067. Epub 2018 May 31.
PubMed
Associated Plasmids |
| SRSF2 mutations drive oncogenesis by activating a global program of aberrant alternative splicing in hematopoietic cells. Liang Y, Tebaldi T, Rejeski K, Joshi P, Stefani G, Taylor A, Song Y, Vasic R, Maziarz J, Balasubramanian K, Ardasheva A, Ding A, Quattrone A, Halene S. Leukemia. 2018 Dec;32(12):2659-2671. doi: 10.1038/s41375-018-0152-7. Epub 2018 Jun 1. PubMed |
| PAK1 regulates ATXN1 levels providing an opportunity to modify its toxicity in spinocerebellar ataxia type 1. Bondar VV, Adamski CJ, Onur TS, Tan Q, Wang L, Diaz-Garcia J, Park J, Orr HT, Botas J, Zoghbi HY. Hum Mol Genet. 2018 Aug 15;27(16):2863-2873. doi: 10.1093/hmg/ddy200. PubMed |
| Methylation of hypoxia-inducible factor (HIF)-1alpha by G9a/GLP inhibits HIF-1 transcriptional activity and cell migration. Bao L, Chen Y, Lai HT, Wu SY, Wang JE, Hatanpaa KJ, Raisanen JM, Fontenot M, Lega B, Chiang CM, Semenza GL, Wang Y, Luo W. Nucleic Acids Res. 2018 Jul 27;46(13):6576-6591. doi: 10.1093/nar/gky449. PubMed |
| Specificity of RNAi, LNA and CRISPRi as loss-of-function methods in transcriptional analysis. Stojic L, Lun ATL, Mangei J, Mascalchi P, Quarantotti V, Barr AR, Bakal C, Marioni JC, Gergely F, Odom DT. Nucleic Acids Res. 2018 Jul 6;46(12):5950-5966. doi: 10.1093/nar/gky437. PubMed |
Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR.
Walton ZE, Patel CH, Brooks RC, Yu Y, Ibrahim-Hashim A, Riddle M, Porcu A, Jiang T, Ecker BL, Tameire F, Koumenis C, Weeraratna AT, Welsh DK, Gillies R, Alwine JC, Zhang L, Powell JD, Dang CV.
Cell. 2018 Jun 28;174(1):72-87.e32. doi: 10.1016/j.cell.2018.05.009. Epub 2018 May 31.
PubMed
Associated Plasmids |
| PPARgamma is dispensable for clear cell renal cell carcinoma progression. Sanchez DJ, Steger DJ, Skuli N, Bansal A, Simon MC. Mol Metab. 2018 Aug;14:139-149. doi: 10.1016/j.molmet.2018.05.013. Epub 2018 May 21. PubMed |
| Gastrointestinal stromal tumor enhancers support a transcription factor network predictive of clinical outcome. Hemming ML, Lawlor MA, Zeid R, Lesluyes T, Fletcher JA, Raut CP, Sicinska ET, Chibon F, Armstrong SA, Demetri GD, Bradner JE. Proc Natl Acad Sci U S A. 2018 Jun 19;115(25):E5746-E5755. doi: 10.1073/pnas.1802079115. Epub 2018 Jun 4. PubMed |
| Temozolomide lymphodepletion enhances CAR abundance and correlates with antitumor efficacy against established glioblastoma. Suryadevara CM, Desai R, Abel ML, Riccione KA, Batich KA, Shen SH, Chongsathidkiet P, Gedeon PC, Elsamadicy AA, Snyder DJ, Herndon JE 2nd, Healy P, Archer GE, Choi BD, Fecci PE, Sampson JH, Sanchez-Perez L. Oncoimmunology. 2018 Feb 21;7(6):e1434464. doi: 10.1080/2162402X.2018.1434464. eCollection 2018. PubMed |
| Frequent sgRNA-barcode recombination in single-cell perturbation assays. Xie S, Cooley A, Armendariz D, Zhou P, Hon GC. PLoS One. 2018 Jun 6;13(6):e0198635. doi: 10.1371/journal.pone.0198635. eCollection 2018. PubMed |
| Kaposi's Sarcoma-Associated Herpesvirus ORF68 Is a DNA Binding Protein Required for Viral Genome Cleavage and Packaging. Gardner MR, Glaunsinger BA. J Virol. 2018 Jul 31;92(16). pii: JVI.00840-18. doi: 10.1128/JVI.00840-18. Print 2018 Aug 15. PubMed |
| Pharmacological inhibition of dihydroorotate dehydrogenase induces apoptosis and differentiation in acute myeloid leukemia cells. Wu D, Wang W, Chen W, Lian F, Lang L, Huang Y, Xu Y, Zhang N, Chen Y, Liu M, Nussinov R, Cheng F, Lu W, Huang J. Haematologica. 2018 Sep;103(9):1472-1483. doi: 10.3324/haematol.2018.188185. Epub 2018 Jun 7. PubMed |
| The transcription factor Zfp90 regulates the self-renewal and differentiation of hematopoietic stem cells. Liu T, Kong WX, Tang XY, Xu M, Wang QH, Zhang B, Hu LD, Chen H. Cell Death Dis. 2018 Jun 7;9(6):677. doi: 10.1038/s41419-018-0721-8. PubMed |
| CRISPR-Cas9 genome editing induces a p53-mediated DNA damage response. Haapaniemi E, Botla S, Persson J, Schmierer B, Taipale J. Nat Med. 2018 Jul;24(7):927-930. doi: 10.1038/s41591-018-0049-z. Epub 2018 Jun 11. PubMed |
| Nicotinamide adenine dinucleotide is transported into mammalian mitochondria. Davila A, Liu L, Chellappa K, Redpath P, Nakamaru-Ogiso E, Paolella LM, Zhang Z, Migaud ME, Rabinowitz JD, Baur JA. Elife. 2018 Jun 12;7. pii: 33246. doi: 10.7554/eLife.33246. PubMed |
| An immortalised mesenchymal stem cell line maintains mechano-responsive behaviour and can be used as a reporter of substrate stiffness. Galarza Torre A, Shaw JE, Wood A, Gilbert HTJ, Dobre O, Genever P, Brennan K, Richardson SM, Swift J. Sci Rep. 2018 Jun 12;8(1):8981. doi: 10.1038/s41598-018-27346-9. PubMed |
A platform of BRET-FRET hybrid biosensors for optogenetics, chemical screening, and in vivo imaging.
Komatsu N, Terai K, Imanishi A, Kamioka Y, Sumiyama K, Jin T, Okada Y, Nagai T, Matsuda M.
Sci Rep. 2018 Jun 12;8(1):8984. doi: 10.1038/s41598-018-27174-x.
PubMed
Associated Plasmids |
| Telomerase reverse transcriptase interference synergistically promotes tumor necrosis factorrelated apoptosisinducing ligandinduced oral squamous cell carcinoma apoptosis and suppresses proliferation in vitro and in vivo. Zhao X, Zhang C, Le Z, Zeng S, Pan C, Shi J, Wang J, Zhao X. Int J Mol Med. 2018 Sep;42(3):1283-1294. doi: 10.3892/ijmm.2018.3721. Epub 2018 Jun 7. PubMed |
| Knockout of USP19 Deubiquitinating Enzyme Prevents Muscle Wasting by Modulating Insulin and Glucocorticoid Signaling. Coyne ES, Bedard N, Wykes L, Stretch C, Jammoul S, Li S, Zhang K, Sladek RS, Bathe OF, Jagoe RT, Posner BI, Wing SS. Endocrinology. 2018 Aug 1;159(8):2966-2977. doi: 10.1210/en.2018-00290. PubMed |
| Activity-Dependent Actin Remodeling at the Base of Dendritic Spines Promotes Microtubule Entry. Schatzle P, Esteves da Silva M, Tas RP, Katrukha EA, Hu HY, Wierenga CJ, Kapitein LC, Hoogenraad CC. Curr Biol. 2018 Jul 9;28(13):2081-2093.e6. doi: 10.1016/j.cub.2018.05.004. Epub 2018 Jun 14. PubMed |
| Cryptic exon splicing function of TARDBP interacts with autophagy in nervous tissue. Torres P, Ramirez-Nunez O, Romero-Guevara R, Bares G, Granado-Serrano AB, Ayala V, Boada J, Fontdevila L, Povedano M, Sanchis D, Pamplona R, Ferrer I, Portero-Otin M. Autophagy. 2018;14(8):1398-1403. doi: 10.1080/15548627.2018.1474311. Epub 2018 Jul 28. PubMed |
| Trehalose reduces retinal degeneration, neuroinflammation and storage burden caused by a lysosomal hydrolase deficiency. Lotfi P, Tse DY, Di Ronza A, Seymour ML, Martano G, Cooper JD, Pereira FA, Passafaro M, Wu SM, Sardiello M. Autophagy. 2018;14(8):1419-1434. doi: 10.1080/15548627.2018.1474313. Epub 2018 Jul 23. PubMed |
Transcription Factor-Mediated Differentiation of Human iPSCs into Neurons.
Fernandopulle MS, Prestil R, Grunseich C, Wang C, Gan L, Ward ME.
Curr Protoc Cell Biol. 2018 Jun;79(1):e51. doi: 10.1002/cpcb.51. Epub 2018 May 18.
PubMed
Associated Plasmids |
| A multiprotein supercomplex controlling oncogenic signalling in lymphoma. Phelan JD, Young RM, Webster DE, Roulland S, Wright GW, Kasbekar M, Shaffer AL 3rd, Ceribelli M, Wang JQ, Schmitz R, Nakagawa M, Bachy E, Huang DW, Ji Y, Chen L, Yang Y, Zhao H, Yu X, Xu W, Palisoc MM, Valadez RR, Davies-Hill T, Wilson WH, Chan WC, Jaffe ES, Gascoyne RD, Campo E, Rosenwald A, Ott G, Delabie J, Rimsza LM, Rodriguez FJ, Estephan F, Holdhoff M, Kruhlak MJ, Hewitt SM, Thomas CJ, Pittaluga S, Oellerich T, Staudt LM. Nature. 2018 Aug;560(7718):387-391. doi: 10.1038/s41586-018-0290-0. Epub 2018 Jun 20. PubMed |
| CAPTURE: In Situ Analysis of Chromatin Composition of Endogenous Genomic Loci by Biotinylated dCas9. Liu X, Zhang Y, Chen Y, Li M, Shao Z, Zhang MQ, Xu J. Curr Protoc Mol Biol. 2018 Jul;123(1):e64. doi: 10.1002/cpmb.64. Epub 2018 Jun 19. PubMed |
| Flap endonuclease 1 is involved in cccDNA formation in the hepatitis B virus. Kitamura K, Que L, Shimadu M, Koura M, Ishihara Y, Wakae K, Nakamura T, Watashi K, Wakita T, Muramatsu M. PLoS Pathog. 2018 Jun 21;14(6):e1007124. doi: 10.1371/journal.ppat.1007124. eCollection 2018 Jun. PubMed |
| X chromosome protects against bladder cancer in females via a KDM6A-dependent epigenetic mechanism. Kaneko S, Li X. Sci Adv. 2018 Jun 13;4(6):eaar5598. doi: 10.1126/sciadv.aar5598. eCollection 2018 Jun. PubMed |
| NEK1 loss-of-function mutation induces DNA damage accumulation in ALS patient-derived motoneurons. Higelin J, Catanese A, Semelink-Sedlacek LL, Oeztuerk S, Lutz AK, Bausinger J, Barbi G, Speit G, Andersen PM, Ludolph AC, Demestre M, Boeckers TM. Stem Cell Res. 2018 Jul;30:150-162. doi: 10.1016/j.scr.2018.06.005. Epub 2018 Jun 12. PubMed |
| Transbilayer phospholipid movement facilitates the translocation of annexin across membranes. Stewart SE, Ashkenazi A, Williamson A, Rubinsztein DC, Moreau K. J Cell Sci. 2018 Jul 19;131(14). pii: jcs.217034. doi: 10.1242/jcs.217034. PubMed |
| A Ca(2+)-stimulated exosome release pathway in cancer cells is regulated by Munc13-4. Messenger SW, Woo SS, Sun Z, Martin TFJ. J Cell Biol. 2018 Aug 6;217(8):2877-2890. doi: 10.1083/jcb.201710132. Epub 2018 Jun 21. PubMed |
| Apoptotic Cell-Derived Extracellular Vesicles Promote Malignancy of Glioblastoma Via Intercellular Transfer of Splicing Factors. Pavlyukov MS, Yu H, Bastola S, Minata M, Shender VO, Lee Y, Zhang S, Wang J, Komarova S, Wang J, Yamaguchi S, Alsheikh HA, Shi J, Chen D, Mohyeldin A, Kim SH, Shin YJ, Anufrieva K, Evtushenko EG, Antipova NV, Arapidi GP, Govorun V, Pestov NB, Shakhparonov MI, Lee LJ, Nam DH, Nakano I. Cancer Cell. 2018 Jul 9;34(1):119-135.e10. doi: 10.1016/j.ccell.2018.05.012. Epub 2018 Jun 21. PubMed |
| Identification, characterization and application of a new peptide against anterior gradient homolog 2 (AGR2). Garri C, Howell S, Tiemann K, Tiffany A, Jalali-Yazdi F, Alba MM, Katz JE, Takahashi TT, Landgraf R, Gross ME, Roberts RW, Kani K. Oncotarget. 2018 Jun 8;9(44):27363-27379. doi: 10.18632/oncotarget.25221. eCollection 2018 Jun 8. PubMed |
| An in vivo model for thyroid regeneration and folliculogenesis. Iwadate M, Takizawa Y, Shirai YT, Kimura S. Lab Invest. 2018 Sep;98(9):1126-1132. doi: 10.1038/s41374-018-0068-x. Epub 2018 Jun 26. PubMed |
| Epstein-Barr virus-encoded EBNA2 alters immune checkpoint PD-L1 expression by downregulating miR-34a in B-cell lymphomas. Anastasiadou E, Stroopinsky D, Alimperti S, Jiao AL, Pyzer AR, Cippitelli C, Pepe G, Severa M, Rosenblatt J, Etna MP, Rieger S, Kempkes B, Coccia EM, Sui SJH, Chen CS, Uccini S, Avigan D, Faggioni A, Trivedi P, Slack FJ. Leukemia. 2019 Jan;33(1):132-147. doi: 10.1038/s41375-018-0178-x. Epub 2018 Jun 26. PubMed |
Multimodal cell tracking from systemic administration to tumour growth by combining gold nanorods and reporter genes.
Comenge J, Sharkey J, Fragueiro O, Wilm B, Brust M, Murray P, Levy R, Plagge A.
Elife. 2018 Jun 27;7. pii: 33140. doi: 10.7554/eLife.33140.
PubMed
Associated Plasmids |
| Transcription factor NFE2L2/NRF2 modulates chaperone-mediated autophagy through the regulation of LAMP2A. Pajares M, Rojo AI, Arias E, Diaz-Carretero A, Cuervo AM, Cuadrado A. Autophagy. 2018;14(8):1310-1322. doi: 10.1080/15548627.2018.1474992. Epub 2018 Jul 26. PubMed |
| Keratinocyte differentiation induces APOBEC3A, 3B, and mitochondrial DNA hypermutation. Wakae K, Nishiyama T, Kondo S, Izuka T, Que L, Chen C, Kase K, Kitamura K, Mohiuddin M, Wang Z, Ahasan MM, Nakamura M, Fujiwara H, Yoshizaki T, Hosomochi K, Tajima A, Nakahara T, Kiyono T, Muramatsu M. Sci Rep. 2018 Jun 27;8(1):9745. doi: 10.1038/s41598-018-27930-z. PubMed |
| Promoter interactome of human embryonic stem cell-derived cardiomyocytes connects GWAS regions to cardiac gene networks. Choy MK, Javierre BM, Williams SG, Baross SL, Liu Y, Wingett SW, Akbarov A, Wallace C, Freire-Pritchett P, Rugg-Gunn PJ, Spivakov M, Fraser P, Keavney BD. Nat Commun. 2018 Jun 28;9(1):2526. doi: 10.1038/s41467-018-04931-0. PubMed |
| CBFbeta-SMMHC Inhibition Triggers Apoptosis by Disrupting MYC Chromatin Dynamics in Acute Myeloid Leukemia. Pulikkan JA, Hegde M, Ahmad HM, Belaghzal H, Illendula A, Yu J, O'Hagan K, Ou J, Muller-Tidow C, Wolfe SA, Zhu LJ, Dekker J, Bushweller JH, Castilla LH. Cell. 2018 Jun 28;174(1):172-186.e21. doi: 10.1016/j.cell.2018.05.048. PubMed |
| miR-876-3p regulates glucose homeostasis and insulin sensitivity by targeting adiponectin. Rajan S, Panzade G, Srivastava A, Shankar K, Pandey R, Kumar D, Gupta S, Gupta A, Varshney S, Beg M, Mishra RK, Shankar R, Gaikwad AN. J Endocrinol. 2018 Jul 2. pii: JOE-17-0387. doi: 10.1530/JOE-17-0387. PubMed |
| Synthetic far-red light-mediated CRISPR-dCas9 device for inducing functional neuronal differentiation. Shao J, Wang M, Yu G, Zhu S, Yu Y, Heng BC, Wu J, Ye H. Proc Natl Acad Sci U S A. 2018 Jul 17;115(29):E6722-E6730. doi: 10.1073/pnas.1802448115. Epub 2018 Jul 2. PubMed |
| MicroRNAs Overcome Cell Fate Barrier by Reducing EZH2-Controlled REST Stability during Neuronal Conversion of Human Adult Fibroblasts. Lee SW, Oh YM, Lu YL, Kim WK, Yoo AS. Dev Cell. 2018 Jul 2;46(1):73-84.e7. doi: 10.1016/j.devcel.2018.06.007. PubMed |
| Spontaneous reactivation of latent HIV-1 promoters is linked to the cell cycle as revealed by a genetic-insulators-containing dual-fluorescence HIV-1-based vector. Kok YL, Schmutz S, Inderbitzin A, Neumann K, Kelley A, Jorimann L, Shilaih M, Vongrad V, Kouyos RD, Gunthard HF, Berens C, Metzner KJ. Sci Rep. 2018 Jul 5;8(1):10204. doi: 10.1038/s41598-018-28161-y. PubMed |
| Transcription factor induced conversion of human fibroblasts towards the hair cell lineage. Duran Alonso MB, Lopez Hernandez I, de la Fuente MA, Garcia-Sancho J, Giraldez F, Schimmang T. PLoS One. 2018 Jul 6;13(7):e0200210. doi: 10.1371/journal.pone.0200210. eCollection 2018. PubMed |
| MicroRNA-132 provides neuroprotection for tauopathies via multiple signaling pathways. El Fatimy R, Li S, Chen Z, Mushannen T, Gongala S, Wei Z, Balu DT, Rabinovsky R, Cantlon A, Elkhal A, Selkoe DJ, Sonntag KC, Walsh DM, Krichevsky AM. Acta Neuropathol. 2018 Oct;136(4):537-555. doi: 10.1007/s00401-018-1880-5. Epub 2018 Jul 7. PubMed |
| A versatile lentiviral delivery toolkit for proximity-dependent biotinylation in diverse cell types. Samavarchi-Tehrani P, Abdouni H, Samson R, Gingras AC. Mol Cell Proteomics. 2018 Jul 10. pii: TIR118.000902. doi: 10.1074/mcp.TIR118.000902. PubMed |
| Angiotropism and extravascular migratory metastasis in cutaneous and uveal melanoma progression in a zebrafish model. Fornabaio G, Barnhill RL, Lugassy C, Bentolila LA, Cassoux N, Roman-Roman S, Alsafadi S, Del Bene F. Sci Rep. 2018 Jul 11;8(1):10448. doi: 10.1038/s41598-018-28515-6. PubMed |
| Myosin X is required for efficient melanoblast migration and melanoma initiation and metastasis. Tokuo H, Bhawan J, Coluccio LM. Sci Rep. 2018 Jul 11;8(1):10449. doi: 10.1038/s41598-018-28717-y. PubMed |
| WDR41 supports lysosomal response to changes in amino acid availability. Amick J, Tharkeshwar AK, Amaya C, Ferguson SM. Mol Biol Cell. 2018 Sep 1;29(18):2213-2227. doi: 10.1091/mbc.E17-12-0703. Epub 2018 Jul 11. PubMed |
| Human Cytomegalovirus Tropism Modulator UL148 Interacts with SEL1L, a Cellular Factor That Governs Endoplasmic Reticulum-Associated Degradation of the Viral Envelope Glycoprotein gO. Nguyen CC, Siddiquey MNA, Zhang H, Li G, Kamil JP. J Virol. 2018 Aug 29;92(18). pii: JVI.00688-18. doi: 10.1128/JVI.00688-18. Print 2018 Sep 15. PubMed |
| Vesicular stomatitis virus G protein transmembrane region is crucial for the hemi-fusion to full fusion transition. Ci Y, Yang Y, Xu C, Shi L. Sci Rep. 2018 Jul 13;8(1):10669. doi: 10.1038/s41598-018-28868-y. PubMed |
| EZH2-Mediated Primary Cilium Deconstruction Drives Metastatic Melanoma Formation. Zingg D, Debbache J, Pena-Hernandez R, Antunes AT, Schaefer SM, Cheng PF, Zimmerli D, Haeusel J, Calcada RR, Tuncer E, Zhang Y, Bossart R, Wong KK, Basler K, Dummer R, Santoro R, Levesque MP, Sommer L. Cancer Cell. 2018 Jul 9;34(1):69-84.e14. doi: 10.1016/j.ccell.2018.06.001. Epub 2018 Jun 28. PubMed |
An enhanced CRISPR repressor for targeted mammalian gene regulation.
Yeo NC, Chavez A, Lance-Byrne A, Chan Y, Menn D, Milanova D, Kuo CC, Guo X, Sharma S, Tung A, Cecchi RJ, Tuttle M, Pradhan S, Lim ET, Davidsohn N, Ebrahimkhani MR, Collins JJ, Lewis NE, Kiani S, Church GM.
Nat Methods. 2018 Jul 16. pii: 10.1038/s41592-018-0048-5. doi: 10.1038/s41592-018-0048-5.
PubMed
Associated Plasmids |
| Mutant ASXL1 cooperates with BAP1 to promote myeloid leukaemogenesis. Asada S, Goyama S, Inoue D, Shikata S, Takeda R, Fukushima T, Yonezawa T, Fujino T, Hayashi Y, Kawabata KC, Fukuyama T, Tanaka Y, Yokoyama A, Yamazaki S, Kozuka-Hata H, Oyama M, Kojima S, Kawazu M, Mano H, Kitamura T. Nat Commun. 2018 Jul 16;9(1):2733. doi: 10.1038/s41467-018-05085-9. PubMed |
| Deguelin attenuates non-small cell lung cancer cell metastasis through inhibiting the CtsZ/FAK signaling pathway. Li W, Yu X, Ma X, Xie L, Xia Z, Liu L, Yu X, Wang J, Zhou H, Zhou X, Yang Y, Liu H. Cell Signal. 2018 Oct;50:131-141. doi: 10.1016/j.cellsig.2018.07.001. Epub 2018 Jul 7. PubMed |
| Unique BIR domain sets determine inhibitor of apoptosis protein-driven cell death and NOD2 complex signal specificity. Chirieleison SM, Rathkey JK, Abbott DW. Sci Signal. 2018 Jul 17;11(539). pii: 11/539/eaao3964. doi: 10.1126/scisignal.aao3964. PubMed |
| MiR-129 regulates growth and invasion by targeting MAL2 in papillary thyroid carcinoma. Gao X, Chen Z, Li A, Zhang X, Cai X. Biomed Pharmacother. 2018 Sep;105:1072-1078. doi: 10.1016/j.biopha.2018.06.050. Epub 2018 Jun 19. PubMed |
| Shieldin complex promotes DNA end-joining and counters homologous recombination in BRCA1-null cells. Dev H, Chiang TW, Lescale C, de Krijger I, Martin AG, Pilger D, Coates J, Sczaniecka-Clift M, Wei W, Ostermaier M, Herzog M, Lam J, Shea A, Demir M, Wu Q, Yang F, Fu B, Lai Z, Balmus G, Belotserkovskaya R, Serra V, O'Connor MJ, Bruna A, Beli P, Pellegrini L, Caldas C, Deriano L, Jacobs JJL, Galanty Y, Jackson SP. Nat Cell Biol. 2018 Aug;20(8):954-965. doi: 10.1038/s41556-018-0140-1. Epub 2018 Jul 18. PubMed |
| Single Copy Transgene Integration in a Transcriptionally Active Site for Recombinant Protein Synthesis. O'Brien SA, Lee K, Fu HY, Lee Z, Le TS, Stach CS, McCann MG, Zhang AQ, Smanski MJ, Somia NV, Hu WS. Biotechnol J. 2018 Oct;13(10):e1800226. doi: 10.1002/biot.201800226. Epub 2018 Jul 30. PubMed |
| Direct Reprogramming of Fibroblasts Into Smooth Muscle-Like Cells With Defined Transcription Factors-Brief Report. Hirai H, Yang B, Garcia-Barrio MT, Rom O, Ma PX, Zhang J, Chen YE. Arterioscler Thromb Vasc Biol. 2018 Sep;38(9):2191-2197. doi: 10.1161/ATVBAHA.118.310870. PubMed |
| A genome-scale CRISPR-Cas9 screening in myeloma cells identifies regulators of immunomodulatory drug sensitivity. Liu J, Song T, Zhou W, Xing L, Wang S, Ho M, Peng Z, Tai YT, Hideshima T, Anderson KC, Cang Y. Leukemia. 2019 Jan;33(1):171-180. doi: 10.1038/s41375-018-0205-y. Epub 2018 Jul 19. PubMed |
| NAT6 acetylates the N-terminus of different forms of actin. Wiame E, Tahay G, Tyteca D, Vertommen D, Stroobant V, Bommer GT, Van Schaftingen E. FEBS J. 2018 Sep;285(17):3299-3316. doi: 10.1111/febs.14605. Epub 2018 Aug 13. PubMed |
| Translational Control through Differential Ribosome Pausing during Amino Acid Limitation in Mammalian Cells. Darnell AM, Subramaniam AR, O'Shea EK. Mol Cell. 2018 Jul 19;71(2):229-243.e11. doi: 10.1016/j.molcel.2018.06.041. PubMed |
| Risk SNP-Mediated Promoter-Enhancer Switching Drives Prostate Cancer through lncRNA PCAT19. Hua JT, Ahmed M, Guo H, Zhang Y, Chen S, Soares F, Lu J, Zhou S, Wang M, Li H, Larson NB, McDonnell SK, Patel PS, Liang Y, Yao CQ, van der Kwast T, Lupien M, Feng FY, Zoubeidi A, Tsao MS, Thibodeau SN, Boutros PC, He HH. Cell. 2018 Jul 26;174(3):564-575.e18. doi: 10.1016/j.cell.2018.06.014. Epub 2018 Jul 19. PubMed |
| MUNC, an Enhancer RNA Upstream from the MYOD Gene, Induces a Subgroup of Myogenic Transcripts in trans Independently of MyoD. Cichewicz MA, Kiran M, Przanowska RK, Sobierajska E, Shibata Y, Dutta A. Mol Cell Biol. 2018 Sep 28;38(20). pii: MCB.00655-17. doi: 10.1128/MCB.00655-17. Print 2018 Oct 15. PubMed |
| Exposure to galactic cosmic radiation compromises DNA repair and increases the potential for oncogenic chromosomal rearrangement in bronchial epithelial cells. Li Z, Jella KK, Jaafar L, Li S, Park S, Story MD, Wang H, Wang Y, Dynan WS. Sci Rep. 2018 Jul 23;8(1):11038. doi: 10.1038/s41598-018-29350-5. PubMed |
The Human Cytomegalovirus Endoplasmic Reticulum-Resident Glycoprotein UL148 Activates the Unfolded Protein Response.
Siddiquey MNA, Zhang H, Nguyen CC, Domma AJ, Kamil JP.
J Virol. 2018 Sep 26;92(20). pii: JVI.00896-18. doi: 10.1128/JVI.00896-18. Print 2018 Oct 15.
PubMed
Associated Plasmids |
| 3D-cultured neural stem cell microarrays on a micropillar chip for high-throughput developmental neurotoxicology. Joshi P, Yu KN, Kang SY, Kwon SJ, Kwon PS, Dordick JS, Kothapalli CR, Lee MY. Exp Cell Res. 2018 Sep 15;370(2):680-691. doi: 10.1016/j.yexcr.2018.07.034. Epub 2018 Jul 24. PubMed |
Mitochondrial inner membrane permeabilisation enables mtDNA release during apoptosis.
Riley JS, Quarato G, Cloix C, Lopez J, O'Prey J, Pearson M, Chapman J, Sesaki H, Carlin LM, Passos JF, Wheeler AP, Oberst A, Ryan KM, Tait SW.
EMBO J. 2018 Sep 3;37(17). pii: embj.201899238. doi: 10.15252/embj.201899238. Epub 2018 Jul 26.
PubMed
Associated Plasmids |
| Frontline Science: RIP2 promotes house dust mite-induced allergic airway inflammation. Miller MH, Shehat MG, Alcedo KP, Spinel LP, Soulakova J, Tigno-Aranjuez JT. J Leukoc Biol. 2018 Sep;104(3):447-459. doi: 10.1002/JLB.4HI0118-017RR. Epub 2018 Jul 27. PubMed |
| Regulation of the adaptation to ER stress by KLF4 facilitates melanoma cell metastasis via upregulating NUCB2 expression. Zhang D, Lin J, Chao Y, Zhang L, Jin L, Li N, He R, Ma B, Zhao W, Han C. J Exp Clin Cancer Res. 2018 Jul 28;37(1):176. doi: 10.1186/s13046-018-0842-z. PubMed |
| An Unbiased Screen for Human Cytomegalovirus Identifies Neuropilin-2 as a Central Viral Receptor. Martinez-Martin N, Marcandalli J, Huang CS, Arthur CP, Perotti M, Foglierini M, Ho H, Dosey AM, Shriver S, Payandeh J, Leitner A, Lanzavecchia A, Perez L, Ciferri C. Cell. 2018 Aug 23;174(5):1158-1171.e19. doi: 10.1016/j.cell.2018.06.028. Epub 2018 Jul 26. PubMed |
| Monitoring implantable immunoisolation devices with intrinsic fluorescence of genipin. Santos-Vizcaino E, Haley H, Gonzalez-Pujana A, Orive G, Hernandez RM, Luker GD, Pedraz JL. J Biophotonics. 2019 Apr;12(4):e201800170. doi: 10.1002/jbio.201800170. Epub 2018 Sep 25. PubMed |
The actin cytoskeletal architecture of estrogen receptor positive breast cancer cells suppresses invasion.
Padilla-Rodriguez M, Parker SS, Adams DG, Westerling T, Puleo JI, Watson AW, Hill SM, Noon M, Gaudin R, Aaron J, Tong D, Roe DJ, Knudsen B, Mouneimne G.
Nat Commun. 2018 Jul 30;9(1):2980. doi: 10.1038/s41467-018-05367-2.
PubMed
Associated Plasmids |
| Programmable DNA repair with CRISPRa/i enhanced homology-directed repair efficiency with a single Cas9. Ye L, Wang C, Hong L, Sun N, Chen D, Chen S, Han F. Cell Discov. 2018 Jul 24;4:46. doi: 10.1038/s41421-018-0049-7. eCollection 2018. PubMed |
| Proteomic interaction profiling reveals KIFC1 as a factor involved in early targeting of F508del-CFTR to degradation. Canato S, Santos JD, Carvalho AS, Aloria K, Amaral MD, Matthiesen R, Falcao AO, Farinha CM. Cell Mol Life Sci. 2018 Dec;75(24):4495-4509. doi: 10.1007/s00018-018-2896-7. Epub 2018 Jul 31. PubMed |
| HIV-1 Employs Multiple Mechanisms To Resist Cas9/Single Guide RNA Targeting the Viral Primer Binding Site. Wang Z, Wang W, Cui YC, Pan Q, Zhu W, Gendron P, Guo F, Cen S, Witcher M, Liang C. J Virol. 2018 Sep 26;92(20). pii: JVI.01135-18. doi: 10.1128/JVI.01135-18. Print 2018 Oct 15. PubMed |
Identification of SMCHD1 domains for nuclear localization, homo-dimerization, and protein cleavage.
Hiramuki Y, Tapscott SJ.
Skelet Muscle. 2018 Aug 2;8(1):24. doi: 10.1186/s13395-018-0172-z.
PubMed
Associated Plasmids |
| JMJD2B/KDM4B inactivation in adipose tissues accelerates obesity and systemic metabolic abnormalities. Kang C, Saso K, Ota K, Kawazu M, Ueda T, Okada H. Genes Cells. 2018 Sep;23(9):767-777. doi: 10.1111/gtc.12627. Epub 2018 Aug 2. PubMed |
| CRMP4a suppresses cell motility by sequestering RhoA activity in prostate cancer cells. Li C, Xu H, Xiao L, Zhu H, Zhang G, Wei W, Li K, Cao X, Shen D, Holzbeierlein J, Li B. Cancer Biol Ther. 2018 Aug 6:1-11. doi: 10.1080/15384047.2018.1491507. PubMed |
| HDAC11 suppresses the thermogenic program of adipose tissue via BRD2. Bagchi RA, Ferguson BS, Stratton MS, Hu T, Cavasin MA, Sun L, Lin YH, Liu D, Londono P, Song K, Pino MF, Sparks LM, Smith SR, Scherer PE, Collins S, Seto E, McKinsey TA. JCI Insight. 2018 Aug 9;3(15). pii: 120159. doi: 10.1172/jci.insight.120159. eCollection 2018 Aug 9. PubMed |
| AIF promotes a JNK1-mediated cadherin switch independently of respiratory chain stabilization. Scott AJ, Walker SA, Krank JJ, Wilkinson AS, Johnson KM, Lewis EM, Wilkinson JC. J Biol Chem. 2018 Sep 21;293(38):14707-14722. doi: 10.1074/jbc.RA118.004022. Epub 2018 Aug 9. PubMed |
| CXCL1 Derived from Mammary Fibroblasts Promotes Progression of Mammary Lesions to Invasive Carcinoma through CXCR2 Dependent Mechanisms. Bernard S, Myers M, Fang WB, Zinda B, Smart C, Lambert D, Zou A, Fan F, Cheng N. J Mammary Gland Biol Neoplasia. 2018 Dec;23(4):249-267. doi: 10.1007/s10911-018-9407-1. Epub 2018 Aug 9. PubMed |
| Genome Editing of Human Primary Keratinocytes by CRISPR/Cas9 Reveals an Essential Role of the NLRP1 Inflammasome in UVB Sensing. Fenini G, Grossi S, Contassot E, Biedermann T, Reichmann E, French LE, Beer HD. J Invest Dermatol. 2018 Dec;138(12):2644-2652. doi: 10.1016/j.jid.2018.07.016. Epub 2018 Aug 7. PubMed |
| A systems mechanobiology model to predict cardiac reprogramming outcomes on different biomaterials. Kong YP, Rioja AY, Xue X, Sun Y, Fu J, Putnam AJ. Biomaterials. 2018 Oct;181:280-292. doi: 10.1016/j.biomaterials.2018.07.036. Epub 2018 Jul 28. PubMed |
| SF1-Specific AMPKalpha1 Deletion Protects Against Diet-Induced Obesity. Seoane-Collazo P, Roa J, Rial-Pensado E, Linares-Pose L, Beiroa D, Ruiz-Pino F, Lopez-Gonzalez T, Morgan DA, Pardavila JA, Sanchez-Tapia MJ, Martinez-Sanchez N, Contreras C, Fidalgo M, Dieguez C, Coppari R, Rahmouni K, Nogueiras R, Tena-Sempere M, Lopez M. Diabetes. 2018 Nov;67(11):2213-2226. doi: 10.2337/db17-1538. Epub 2018 Aug 13. PubMed |
| Drug-based perturbation screen uncovers synergistic drug combinations in Burkitt lymphoma. Tomska K, Kurilov R, Lee KS, Hullein J, Lukas M, Sellner L, Walther T, Wagner L, Oles M, Brors B, Huber W, Zenz T. Sci Rep. 2018 Aug 13;8(1):12046. doi: 10.1038/s41598-018-30509-3. PubMed |
| Gambogic Acid and Its Analogs Inhibit Gap Junctional Intercellular Communication. Choi EJ, Yeo JH, Yoon SM, Lee J. Front Pharmacol. 2018 Jul 30;9:814. doi: 10.3389/fphar.2018.00814. eCollection 2018. PubMed |
| Entry Inhibition and Modulation of Pro-Inflammatory Immune Response Against Influenza A Virus by a Recombinant Truncated Surfactant Protein D. Al-Ahdal MN, Murugaiah V, Varghese PM, Abozaid SM, Saba I, Al-Qahtani AA, Pathan AA, Kouser L, Nal B, Kishore U. Front Immunol. 2018 Jul 30;9:1586. doi: 10.3389/fimmu.2018.01586. eCollection 2018. PubMed |
| Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy. Logue SE, McGrath EP, Cleary P, Greene S, Mnich K, Almanza A, Chevet E, Dwyer RM, Oommen A, Legembre P, Godey F, Madden EC, Leuzzi B, Obacz J, Zeng Q, Patterson JB, Jager R, Gorman AM, Samali A. Nat Commun. 2018 Aug 15;9(1):3267. doi: 10.1038/s41467-018-05763-8. PubMed |
| Dismissal of RNA Polymerase II Underlies a Large Ligand-Induced Enhancer Decommissioning Program. Tan Y, Jin C, Ma W, Hu Y, Tanasa B, Oh S, Gamliel A, Ma Q, Yao L, Zhang J, Ohgi K, Liu W, Aggarwal AK, Rosenfeld MG. Mol Cell. 2018 Aug 16;71(4):526-539.e8. doi: 10.1016/j.molcel.2018.07.039. PubMed |
| Axoneme polyglutamylation regulated by Joubert syndrome protein ARL13B controls ciliary targeting of signaling molecules. He K, Ma X, Xu T, Li Y, Hodge A, Zhang Q, Torline J, Huang Y, Zhao J, Ling K, Hu J. Nat Commun. 2018 Aug 17;9(1):3310. doi: 10.1038/s41467-018-05867-1. PubMed |
| A Role for p53 in the Adaptation to Glutamine Starvation through the Expression of SLC1A3. Tajan M, Hock AK, Blagih J, Robertson NA, Labuschagne CF, Kruiswijk F, Humpton TJ, Adams PD, Vousden KH. Cell Metab. 2018 Nov 6;28(5):721-736.e6. doi: 10.1016/j.cmet.2018.07.005. Epub 2018 Aug 16. PubMed |
| Epithelial folliculin enhances airway inflammation in aspirin-exacerbated respiratory disease. Trinh HKT, Pham DL, Choi Y, Kim HM, Kim SH, Park HS. Clin Exp Allergy. 2018 Nov;48(11):1464-1473. doi: 10.1111/cea.13253. Epub 2018 Sep 18. PubMed |
| Nrf2 Signaling in Sodium Azide-Treated Oligodendrocytes Restores Mitochondrial Functions. Liessem-Schmitz A, Teske N, Scheld M, Nyamoya S, Zendedel A, Beyer C, Clarner T, Fragoulis A. J Mol Neurosci. 2018 Oct;66(2):229-237. doi: 10.1007/s12031-018-1159-2. Epub 2018 Aug 23. PubMed |
| The tuberous sclerosis complex subunit TBC1D7 is stabilized by Akt phosphorylation-mediated 14-3-3 binding. Madigan JP, Hou F, Ye L, Hu J, Dong A, Tempel W, Yohe ME, Randazzo PA, Jenkins LMM, Gottesman MM, Tong Y. J Biol Chem. 2018 Oct 19;293(42):16142-16159. doi: 10.1074/jbc.RA118.003525. Epub 2018 Aug 24. PubMed |
| TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging. Xu D, Jin T, Zhu H, Chen H, Ofengeim D, Zou C, Mifflin L, Pan L, Amin P, Li W, Shan B, Naito MG, Meng H, Li Y, Pan H, Aron L, Adiconis X, Levin JZ, Yankner BA, Yuan J. Cell. 2018 Sep 6;174(6):1477-1491.e19. doi: 10.1016/j.cell.2018.07.041. Epub 2018 Aug 23. PubMed |
| Phenotypic Lentivirus Screens to Identify Antiviral Single Domain Antibodies. Schmidt FI. Methods Mol Biol. 2018;1836:139-158. doi: 10.1007/978-1-4939-8678-1_7. PubMed |
| G protein pathway suppressor 2 (GPS2) links inflammation and cholesterol efflux by controlling lipopolysaccharide-induced ATP-binding cassette transporter A1 expression in macrophages. Huang Z, Liang N, Damdimopoulos A, Fan R, Treuter E. FASEB J. 2019 Feb;33(2):1631-1643. doi: 10.1096/fj.201801123R. Epub 2018 Aug 28. PubMed |
| Human tryptophanyl-tRNA synthetase is an IFN-gamma-inducible entry factor for Enterovirus. Yeung ML, Jia L, Yip CCY, Chan JFW, Teng JLL, Chan KH, Cai JP, Zhang C, Zhang AJ, Wong WM, Kok KH, Lau SKP, Woo PCY, Lo JYC, Jin DY, Shih SR, Yuen KY. J Clin Invest. 2018 Nov 1;128(11):5163-5177. doi: 10.1172/JCI99411. Epub 2018 Oct 15. PubMed |
| Tolerance to sustained activation of the cAMP/Creb pathway activity in osteoblastic cells is enabled by loss of p53. Walia MK, Taylor S, Ho PWM, Martin TJ, Walkley CR. Cell Death Dis. 2018 Aug 28;9(9):844. doi: 10.1038/s41419-018-0944-8. PubMed |
| Modulation of motor excitability by cortical optogenetic theta burst stimulation. Wu CW, Chiu WT, Hsieh TH, Hsieh CH, Chen JJ. PLoS One. 2018 Aug 30;13(8):e0203333. doi: 10.1371/journal.pone.0203333. eCollection 2018. PubMed |
| Differentiation of Human Pluripotent Stem Cells to Megakaryocytes by Transcription Factor-Driven Forward Programming. Moreau T, Evans AL, Ghevaert CJG. Methods Mol Biol. 2018;1812:155-176. doi: 10.1007/978-1-4939-8585-2_10. PubMed |
| Discovery of a small molecule targeting autophagy via ATG4B inhibition and cell death of colorectal cancer cells in vitro and in vivo. Fu Y, Hong L, Xu J, Zhong G, Gu Q, Gu Q, Guan Y, Zheng X, Dai Q, Luo X, Liu C, Huang Z, Yin XM, Liu P, Li M. Autophagy. 2019 Feb;15(2):295-311. doi: 10.1080/15548627.2018.1517073. Epub 2018 Sep 20. PubMed |
| KLF4, a miR-32-5p targeted gene, promotes cisplatin-induced apoptosis by upregulating BIK expression in prostate cancer. Zhang L, Li X, Chao Y, He R, Liu J, Yuan Y, Zhao W, Han C, Song X. Cell Commun Signal. 2018 Sep 3;16(1):53. doi: 10.1186/s12964-018-0270-x. PubMed |
| Inhibition of TRF2 accelerates telomere attrition and DNA damage in naive CD4 T cells during HCV infection. Nguyen LN, Zhao J, Cao D, Dang X, Wang L, Lian J, Zhang Y, Jia Z, Wu XY, Morrison Z, Xie Q, Ji Y, Zhang Z, El Gazzar M, Ning S, Moorman JP, Yao ZQ. Cell Death Dis. 2018 Sep 5;9(9):900. doi: 10.1038/s41419-018-0897-y. PubMed |
| Bradykinin B2 Receptor Contributes to Inflammatory Responses in Human Endothelial Cells by the Transactivation of the Fibroblast Growth Factor Receptor FGFR-1. Terzuoli E, Corti F, Nannelli G, Giachetti A, Donnini S, Ziche M. Int J Mol Sci. 2018 Sep 6;19(9). pii: ijms19092638. doi: 10.3390/ijms19092638. PubMed |
| Lentiviral vector expression of Klf4 enhances chondrogenesis and reduces hypertrophy in equine chondrocytes. Gurusinghe S, Bandara N, Hilbert B, Trope G, Wang L, Strappe P. Gene. 2019 Jan 5;680:9-19. doi: 10.1016/j.gene.2018.09.013. Epub 2018 Sep 8. PubMed |
| USP7 and USP47 deubiquitinases regulate NLRP3 inflammasome activation. Palazon-Riquelme P, Worboys JD, Green J, Valera A, Martin-Sanchez F, Pellegrini C, Brough D, Lopez-Castejon G. EMBO Rep. 2018 Oct;19(10). pii: embr.201744766. doi: 10.15252/embr.201744766. Epub 2018 Sep 11. PubMed |
| Elevated A20 promotes TNF-induced and RIPK1-dependent intestinal epithelial cell death. Garcia-Carbonell R, Wong J, Kim JY, Close LA, Boland BS, Wong TL, Harris PA, Ho SB, Das S, Ernst PB, Sasik R, Sandborn WJ, Bertin J, Gough PJ, Chang JT, Kelliher M, Boone D, Guma M, Karin M. Proc Natl Acad Sci U S A. 2018 Sep 25;115(39):E9192-E9200. doi: 10.1073/pnas.1810584115. Epub 2018 Sep 12. PubMed |
| Unbiased Genetic Screen to Identify Factors Involved in X-Chromosome Inactivation Using a Pooled Bar-Coded shRNA Library. Moindrot B, Brockdorff N. Methods Mol Biol. 2018;1861:19-36. doi: 10.1007/978-1-4939-8766-5_2. PubMed |
| Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma. McBrayer SK, Mayers JR, DiNatale GJ, Shi DD, Khanal J, Chakraborty AA, Sarosiek KA, Briggs KJ, Robbins AK, Sewastianik T, Shareef SJ, Olenchock BA, Parker SJ, Tateishi K, Spinelli JB, Islam M, Haigis MC, Looper RE, Ligon KL, Bernstein BE, Carrasco RD, Cahill DP, Asara JM, Metallo CM, Yennawar NH, Vander Heiden MG, Kaelin WG Jr. Cell. 2018 Sep 20;175(1):101-116.e25. doi: 10.1016/j.cell.2018.08.038. Epub 2018 Sep 13. PubMed |
| Upregulation of liver kinase B1 predicts poor prognosis in hepatocellular carcinoma. Tan X, Liao Z, Liang H, Chen X, Zhang B, Chu L. Int J Oncol. 2018 Nov;53(5):1913-1926. doi: 10.3892/ijo.2018.4556. Epub 2018 Sep 7. PubMed |
| Human Sox4 facilitates the development of CXCL13-producing helper T cells in inflammatory environments. Yoshitomi H, Kobayashi S, Miyagawa-Hayashino A, Okahata A, Doi K, Nishitani K, Murata K, Ito H, Tsuruyama T, Haga H, Matsuda S, Toguchida J. Nat Commun. 2018 Sep 19;9(1):3762. doi: 10.1038/s41467-018-06187-0. PubMed |
| Promyelocytic leukemia (PML) nuclear bodies (NBs) induce latent/quiescent HSV-1 genomes chromatinization through a PML NB/Histone H3.3/H3.3 Chaperone Axis. Cohen C, Corpet A, Roubille S, Maroui MA, Poccardi N, Rousseau A, Kleijwegt C, Binda O, Texier P, Sawtell N, Labetoulle M, Lomonte P. PLoS Pathog. 2018 Sep 20;14(9):e1007313. doi: 10.1371/journal.ppat.1007313. eCollection 2018 Sep. PubMed |
| Systematic genetic mapping of necroptosis identifies SLC39A7 as modulator of death receptor trafficking. Fauster A, Rebsamen M, Willmann KL, Cesar-Razquin A, Girardi E, Bigenzahn JW, Schischlik F, Scorzoni S, Bruckner M, Konecka J, Hormann K, Heinz LX, Boztug K, Superti-Furga G. Cell Death Differ. 2018 Sep 20. pii: 10.1038/s41418-018-0192-6. doi: 10.1038/s41418-018-0192-6. PubMed |
| G1 phase cell cycle arrest in NSCLC in response to LZ-106, an analog of enoxacin, is orchestrated through ROS overproduction in a P53-dependent manner. Yang L, Zhou J, Meng F, Fu C, Zou X, Liu J, Zhang C, Tan R, Li Z, Guo Q, Wei L. Carcinogenesis. 2019 Mar 12;40(1):131-144. doi: 10.1093/carcin/bgy124. PubMed |
| Cellular RelB interacts with the transactivator Tat and enhance HIV-1 expression. Wang M, Yang W, Chen Y, Wang J, Tan J, Qiao W. Retrovirology. 2018 Sep 21;15(1):65. doi: 10.1186/s12977-018-0447-9. PubMed |
| Discovering human diabetes-risk gene function with genetics and physiological assays. Peiris H, Park S, Louis S, Gu X, Lam JY, Asplund O, Ippolito GC, Bottino R, Groop L, Tucker H, Kim SK. Nat Commun. 2018 Sep 21;9(1):3855. doi: 10.1038/s41467-018-06249-3. PubMed |
| Interactive Repression of MYRF Self-Cleavage and Activity in Oligodendrocyte Differentiation by TMEM98 Protein. Huang H, Teng P, Du J, Meng J, Hu X, Tang T, Zhang Z, Qi YB, Qiu M. J Neurosci. 2018 Nov 14;38(46):9829-9839. doi: 10.1523/JNEUROSCI.0154-18.2018. Epub 2018 Sep 24. PubMed |
| Fam49/CYRI interacts with Rac1 and locally suppresses protrusions. Fort L, Batista JM, Thomason PA, Spence HJ, Whitelaw JA, Tweedy L, Greaves J, Martin KJ, Anderson KI, Brown P, Lilla S, Neilson MP, Tafelmeyer P, Zanivan S, Ismail S, Bryant DM, Tomkinson NCO, Chamberlain LH, Mastick GS, Insall RH, Machesky LM. Nat Cell Biol. 2018 Oct;20(10):1159-1171. doi: 10.1038/s41556-018-0198-9. Epub 2018 Sep 24. PubMed |
| Acute and rapid degradation of endogenous proteins by Trim-Away. Clift D, So C, McEwan WA, James LC, Schuh M. Nat Protoc. 2018 Oct;13(10):2149-2175. doi: 10.1038/s41596-018-0028-3. PubMed |
| Growth inhibition and chemo-radiosensitization of esophageal squamous cell carcinoma by survivin-shRNA lentivirus transfection. Zhou C, Zhang L, Xu P. Oncol Lett. 2018 Oct;16(4):4813-4820. doi: 10.3892/ol.2018.9280. Epub 2018 Aug 8. PubMed |
| The cargo receptor SURF4 promotes the efficient cellular secretion of PCSK9. Emmer BT, Hesketh GG, Kotnik E, Tang VT, Lascuna PJ, Xiang J, Gingras AC, Chen XW, Ginsburg D. Elife. 2018 Sep 25;7. pii: 38839. doi: 10.7554/eLife.38839. PubMed |
| Repression of Noxa by Bmi1 contributes to deguelin-induced apoptosis in non-small cell lung cancer cells. Li W, Yu X, Xia Z, Yu X, Xie L, Ma X, Zhou H, Liu L, Wang J, Yang Y, Liu H. J Cell Mol Med. 2018 Dec;22(12):6213-6227. doi: 10.1111/jcmm.13908. Epub 2018 Sep 25. PubMed |
| BRCA1 Mutation-Specific Responses to 53BP1 Loss-Induced Homologous Recombination and PARP Inhibitor Resistance. Nacson J, Krais JJ, Bernhardy AJ, Clausen E, Feng W, Wang Y, Nicolas E, Cai KQ, Tricarico R, Hua X, DiMarcantonio D, Martinez E, Zong D, Handorf EA, Bellacosa A, Testa JR, Nussenzweig A, Gupta GP, Sykes SM, Johnson N. Cell Rep. 2018 Sep 25;24(13):3513-3527.e7. doi: 10.1016/j.celrep.2018.08.086. PubMed |
| Anoctamin 5/TMEM16E facilitates muscle precursor cell fusion. Whitlock JM, Yu K, Cui YY, Hartzell HC. J Gen Physiol. 2018 Nov 5;150(11):1498-1509. doi: 10.1085/jgp.201812097. Epub 2018 Sep 26. PubMed |
| PLK1 stabilizes a MYC-dependent kinase network in aggressive B cell lymphomas. Ren Y, Bi C, Zhao X, Lwin T, Wang C, Yuan J, Silva AS, Shah BD, Fang B, Li T, Koomen JM, Jiang H, Chavez JC, Pham LV, Sudalagunta PR, Wan L, Wang X, Dalton WS, Moscinski LC, Shain KH, Vose J, Cleveland JL, Sotomayor EM, Fu K, Tao J. J Clin Invest. 2018 Dec 3;128(12):5517-5530. doi: 10.1172/JCI122533. Epub 2018 Nov 5. PubMed |
| Fc Gamma Receptor IIb Expressed in Hepatocytes Promotes Lipid Accumulation and Gluconeogenesis. Shu T, Song X, Cui X, Ge W, Gao R, Wang J. Int J Mol Sci. 2018 Sep 26;19(10). pii: ijms19102932. doi: 10.3390/ijms19102932. PubMed |
High Fidelity Cryopreservation and Recovery of Primary Rodent Cortical Neurons.
Parker SS, Moutal A, Cai S, Chandrasekaran S, Roman MR, Koshy AA, Khanna R, Zinsmaier KE, Mouneimne G.
eNeuro. 2018 Sep 27;5(5). pii: eN-MNT-0135-18. doi: 10.1523/ENEURO.0135-18.2018. eCollection 2018 Sep-Oct.
PubMed
Associated Plasmids |
| Identification of functionally distinct fibro-inflammatory and adipogenic stromal subpopulations in visceral adipose tissue of adult mice. Hepler C, Shan B, Zhang Q, Henry GH, Shao M, Vishvanath L, Ghaben AL, Mobley AB, Strand D, Hon GC, Gupta RK. Elife. 2018 Sep 28;7. pii: 39636. doi: 10.7554/eLife.39636. PubMed |
| Downregulation of SNCA Expression by Targeted Editing of DNA Methylation: A Potential Strategy for Precision Therapy in PD. Kantor B, Tagliafierro L, Gu J, Zamora ME, Ilich E, Grenier C, Huang ZY, Murphy S, Chiba-Falek O. Mol Ther. 2018 Nov 7;26(11):2638-2649. doi: 10.1016/j.ymthe.2018.08.019. Epub 2018 Aug 29. PubMed |
| RAB11FIP5 Expression and Altered Natural Killer Cell Function Are Associated with Induction of HIV Broadly Neutralizing Antibody Responses. Bradley T, Peppa D, Pedroza-Pacheco I, Li D, Cain DW, Henao R, Venkat V, Hora B, Chen Y, Vandergrift NA, Overman RG, Edwards RW, Woods CW, Tomaras GD, Ferrari G, Ginsburg GS, Connors M, Cohen MS, Moody MA, Borrow P, Haynes BF. Cell. 2018 Oct 4;175(2):387-399.e17. doi: 10.1016/j.cell.2018.08.064. Epub 2018 Sep 27. PubMed |
| Subversion of Systemic Glucose Metabolism as a Mechanism to Support the Growth of Leukemia Cells. Ye H, Adane B, Khan N, Alexeev E, Nusbacher N, Minhajuddin M, Stevens BM, Winters AC, Lin X, Ashton JM, Purev E, Xing L, Pollyea DA, Lozupone CA, Serkova NJ, Colgan SP, Jordan CT. Cancer Cell. 2018 Oct 8;34(4):659-673.e6. doi: 10.1016/j.ccell.2018.08.016. Epub 2018 Sep 27. PubMed |
| The DEAD-box RNA-binding protein DDX6 regulates parental RNA decay for cellular reprogramming to pluripotency. Kami D, Kitani T, Nakamura A, Wakui N, Mizutani R, Ohue M, Kametani F, Akimitsu N, Gojo S. PLoS One. 2018 Oct 1;13(10):e0203708. doi: 10.1371/journal.pone.0203708. eCollection 2018. PubMed |
| Analysis of chromatin accessibility uncovers TEAD1 as a regulator of migration in human glioblastoma. Tome-Garcia J, Erfani P, Nudelman G, Tsankov AM, Katsyv I, Tejero R, Bin Zhang, Walsh M, Friedel RH, Zaslavsky E, Tsankova NM. Nat Commun. 2018 Oct 1;9(1):4020. doi: 10.1038/s41467-018-06258-2. PubMed |
All-optical synaptic electrophysiology probes mechanism of ketamine-induced disinhibition.
Fan LZ, Nehme R, Adam Y, Jung ES, Wu H, Eggan K, Arnold DB, Cohen AE.
Nat Methods. 2018 Oct;15(10):823-831. doi: 10.1038/s41592-018-0142-8. Epub 2018 Oct 1.
PubMed
Associated Plasmids |
| Molecular architecture and regulation of BCL10-MALT1 filaments. Schlauderer F, Seeholzer T, Desfosses A, Gehring T, Strauss M, Hopfner KP, Gutsche I, Krappmann D, Lammens K. Nat Commun. 2018 Oct 2;9(1):4041. doi: 10.1038/s41467-018-06573-8. PubMed |
| Single-Cell Analysis of Quiescent HIV Infection Reveals Host Transcriptional Profiles that Regulate Proviral Latency. Bradley T, Ferrari G, Haynes BF, Margolis DM, Browne EP. Cell Rep. 2018 Oct 2;25(1):107-117.e3. doi: 10.1016/j.celrep.2018.09.020. PubMed |
| Breast cancer survival predicted by TP53 mutation status differs markedly depending on treatment. Ungerleider NA, Rao SG, Shahbandi A, Yee D, Niu T, Frey WD, Jackson JG. Breast Cancer Res. 2018 Oct 1;20(1):115. doi: 10.1186/s13058-018-1044-5. PubMed |
| Alpha ketoglutarate levels, regulated by p53 and OGDH, determine autophagy and cell fate/apoptosis in response to Nutlin-3a. Duan L, Perez RE, Maki CG. Cancer Biol Ther. 2019;20(3):252-260. doi: 10.1080/15384047.2018.1523858. Epub 2018 Oct 5. PubMed |
| Compound C inhibits nonsense-mediated RNA decay independently of AMPK. Cheruiyot A, Li S, Nickless A, Roth R, Fitzpatrick JAJ, You Z. PLoS One. 2018 Oct 5;13(10):e0204978. doi: 10.1371/journal.pone.0204978. eCollection 2018. PubMed |
AXL Is a Putative Tumor Suppressor and Dormancy Regulator in Prostate Cancer.
Axelrod HD, Valkenburg KC, Amend SR, Hicks JL, Parsana P, Torga G, DeMarzo AM, Pienta KJ.
Mol Cancer Res. 2019 Feb;17(2):356-369. doi: 10.1158/1541-7786.MCR-18-0718. Epub 2018 Oct 5.
PubMed
Associated Plasmids |
| Geometry-Dependent Arrhythmias in Electrically Excitable Tissues. McNamara HM, Dodson S, Huang YL, Miller EW, Sandstede B, Cohen AE. Cell Syst. 2018 Oct 24;7(4):359-370.e6. doi: 10.1016/j.cels.2018.08.013. Epub 2018 Oct 3. PubMed |
| Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers. Chiarella AM, Wang TA, Butler KV, Jin J, Hathaway NA. J Vis Exp. 2018 Sep 20;(139). doi: 10.3791/58222. PubMed |
Treatment of a metabolic liver disease by in vivo genome base editing in adult mice.
Villiger L, Grisch-Chan HM, Lindsay H, Ringnalda F, Pogliano CB, Allegri G, Fingerhut R, Haberle J, Matos J, Robinson MD, Thony B, Schwank G.
Nat Med. 2018 Oct;24(10):1519-1525. doi: 10.1038/s41591-018-0209-1. Epub 2018 Oct 8.
PubMed
Associated Plasmids |
MYC Interacts with the G9a Histone Methyltransferase to Drive Transcriptional Repression and Tumorigenesis.
Tu WB, Shiah YJ, Lourenco C, Mullen PJ, Dingar D, Redel C, Tamachi A, Ba-Alawi W, Aman A, Al-Awar R, Cescon DW, Haibe-Kains B, Arrowsmith CH, Raught B, Boutros PC, Penn LZ.
Cancer Cell. 2018 Oct 8;34(4):579-595.e8. doi: 10.1016/j.ccell.2018.09.001.
PubMed
Associated Plasmids |
| A newly generated neuronal cell model of CLN7 disease reveals aberrant lysosome motility and impaired cell survival. von Kleist L, Ariunbat K, Braren I, Stauber T, Storch S, Danyukova T. Mol Genet Metab. 2019 Feb;126(2):196-205. doi: 10.1016/j.ymgme.2018.09.009. Epub 2018 Oct 1. PubMed |
The interaction between ORF18 and ORF30 is required for late gene expression in Kaposi's sarcoma-associated herpesvirus.
Castaneda AF, Glaunsinger BA.
J Virol. 2018 Oct 10. pii: JVI.01488-18. doi: 10.1128/JVI.01488-18.
PubMed
Associated Plasmids |
| NRF2 transcriptionally activates the heat shock factor 1 promoter under oxidative stress and affects survival and migration potential of MCF7 cells. Paul S, Ghosh S, Mandal S, Sau S, Pal M. J Biol Chem. 2018 Dec 14;293(50):19303-19316. doi: 10.1074/jbc.RA118.003376. Epub 2018 Oct 11. PubMed |
| Lentiviral-based reporter constructs for profiling chondrogenic activity in primary equine cell populations. Martin-Pena A, Porter RM, Plumton G, McCarrel TM, Morton AJ, Guijarro MV, Ghivizzani SC, Sharma B, Palmer GD. Eur Cell Mater. 2018 Oct 12;36:156-170. doi: 10.22203/eCM.v036a12. PubMed |
| Genome-wide CRISPR-Cas9 viability screen reveals genes involved in TNF-alpha-induced apoptosis of human umbilical vein endothelial cells. Cai M, Li S, Shuai Y, Li J, Tan J, Zeng Q. J Cell Physiol. 2019 Jun;234(6):9184-9193. doi: 10.1002/jcp.27595. Epub 2018 Oct 14. PubMed |
| Transposon mutagenesis screen in mice identifies TM9SF2 as a novel colorectal cancer oncogene. Clark CR, Maile M, Blaney P, Hellweg SR, Strauss A, Durose W, Priya S, Habicht J, Burns MB, Blekhman R, Abrahante JE, Starr TK. Sci Rep. 2018 Oct 17;8(1):15327. doi: 10.1038/s41598-018-33527-3. PubMed |
Farnesyl diphosphate synthase is important for the maintenance of glioblastoma stemness.
Kim HY, Kim DK, Bae SH, Gwak H, Jeon JH, Kim JK, Lee BI, You HJ, Shin DH, Kim YH, Kim SY, Han SS, Shim JK, Lee JH, Kang SG, Jang H.
Exp Mol Med. 2018 Oct 17;50(10):137. doi: 10.1038/s12276-018-0166-2.
PubMed
Associated Plasmids |
| Efficient in situ gene delivery via PEG diacrylate matrices. Shrimali P, Peter M, Singh A, Dalal N, Dakave S, Chiplunkar SV, Tayalia P. Biomater Sci. 2018 Nov 20;6(12):3241-3250. doi: 10.1039/c8bm00916c. PubMed |
| Improved dynamic monitoring of transcriptional activity during longitudinal analysis in the mouse brain. Heo H, Jo J, Jung JI, Han YM, Lee S, Kim SR, Kwon SH, Kim KN, Hwang BJ, Kee Y, Lee BD, Kang D, Her S. Biol Open. 2019 Jan 8;8(1). pii: bio.037168. doi: 10.1242/bio.037168. PubMed |
| Dimerization of an aptamer generated from Ligand-guided selection (LIGS) yields a high affinity scaffold against B-cells. Batool S, Argyropoulos KV, Azad R, Okeoma P, Zumrut H, Bhandari S, Dekhang R, Mallikaratchy PR. Biochim Biophys Acta Gen Subj. 2019 Jan;1863(1):232-240. doi: 10.1016/j.bbagen.2018.10.006. Epub 2018 Oct 17. PubMed |
| A novel lysosome-to-mitochondria signaling pathway disrupted by amyloid-beta oligomers. Norambuena A, Wallrabe H, Cao R, Wang DB, Silva A, Svindrych Z, Periasamy A, Hu S, Tanzi RE, Kim DY, Bloom GS. EMBO J. 2018 Nov 15;37(22):e100241. doi: 10.15252/embj.2018100241. Epub 2018 Oct 22. PubMed |
| Monoubiquitination of ASXLs controls the deubiquitinase activity of the tumor suppressor BAP1. Daou S, Barbour H, Ahmed O, Masclef L, Baril C, Sen Nkwe N, Tchelougou D, Uriarte M, Bonneil E, Ceccarelli D, Mashtalir N, Tanji M, Masson JY, Thibault P, Sicheri F, Yang H, Carbone M, Therrien M, Affar EB. Nat Commun. 2018 Oct 22;9(1):4385. doi: 10.1038/s41467-018-06854-2. PubMed |
| INAVA-ARNO complexes bridge mucosal barrier function with inflammatory signaling. Luong P, Hedl M, Yan J, Zuo T, Fu TM, Jiang X, Thiagarajah JR, Hansen SH, Lesser CF, Wu H, Abraham C, Lencer WI. Elife. 2018 Oct 25;7. pii: 38539. doi: 10.7554/eLife.38539. PubMed |
| A peptide encoded by circular form of LINC-PINT suppresses oncogenic transcriptional elongation in glioblastoma. Zhang M, Zhao K, Xu X, Yang Y, Yan S, Wei P, Liu H, Xu J, Xiao F, Zhou H, Yang X, Huang N, Liu J, He K, Xie K, Zhang G, Huang S, Zhang N. Nat Commun. 2018 Oct 26;9(1):4475. doi: 10.1038/s41467-018-06862-2. PubMed |
Cells Lacking the RB1 Tumor Suppressor Gene Are Hyperdependent on Aurora B Kinase for Survival.
Oser MG, Fonseca R, Chakraborty AA, Brough R, Spektor A, Jennings RB, Flaifel A, Novak JS, Gulati A, Buss E, Younger ST, McBrayer SK, Cowley GS, Bonal DM, Nguyen QD, Brulle-Soumare L, Taylor P, Cairo S, Ryan CJ, Pease EJ, Maratea K, Travers J, Root DE, Signoretti S, Pellman D, Ashton S, Lord CJ, Barry ST, Kaelin WG Jr.
Cancer Discov. 2019 Feb;9(2):230-247. doi: 10.1158/2159-8290.CD-18-0389. Epub 2018 Oct 29.
PubMed
Associated Plasmids |
| Reversal of ApoE4-induced recycling block as a novel prevention approach for Alzheimer's disease. Xian X, Pohlkamp T, Durakoglugil MS, Wong CH, Beck JK, Lane-Donovan C, Plattner F, Herz J. Elife. 2018 Oct 30;7. pii: 40048. doi: 10.7554/eLife.40048. PubMed |
| Foxm1 is a critical driver of TGF-beta-induced EndMT in endothelial cells through Smad2/3 and binds to the Snail promoter. Song S, Zhang R, Cao W, Fang G, Yu Y, Wan Y, Wang C, Li Y, Wang Q. J Cell Physiol. 2019 Jun;234(6):9052-9064. doi: 10.1002/jcp.27583. Epub 2018 Oct 30. PubMed |
| Parkin targets NOD2 to regulate astrocyte endoplasmic reticulum stress and inflammation. Singh K, Han K, Tilve S, Wu K, Geller HM, Sack MN. Glia. 2018 Nov;66(11):2427-2437. doi: 10.1002/glia.23482. Epub 2018 Oct 30. PubMed |
| Loss of endogenous RNF43 function enhances proliferation and tumour growth of intestinal and gastric cells. Neumeyer V, Grandl M, Dietl A, Brutau-Abia A, Allgauer M, Kalali B, Zhang Y, Pan KF, Steiger K, Vieth M, Anton M, Mejias-Luque R, Gerhard M. Carcinogenesis. 2018 Oct 31. pii: 5149556. doi: 10.1093/carcin/bgy152. PubMed |
| Autophagy inhibition as a potential future targeted therapy for ETV6-RUNX1-driven B-cell precursor acute lymphoblastic leukemia. Polak R, Bierings MB, van der Leije CS, Sanders MA, Roovers O, Marchante JRM, Boer JM, Cornelissen JJ, Pieters R, den Boer ML, Buitenhuis M. Haematologica. 2019 Apr;104(4):738-748. doi: 10.3324/haematol.2018.193631. Epub 2018 Oct 31. PubMed |
| Redox regulation of EGFR steers migration of hypoxic mammary cells towards oxygen. Deygas M, Gadet R, Gillet G, Rimokh R, Gonzalo P, Mikaelian I. Nat Commun. 2018 Oct 31;9(1):4545. doi: 10.1038/s41467-018-06988-3. PubMed |
| Novel flavagline-like compounds with potent Fli-1 inhibitory activity suppress diverse types of leukemia. Song J, Yuan C, Yang J, Liu T, Yao Y, Xiao X, Gajendran B, Xu D, Li YJ, Wang C, Liu W, Wen M, Spaner D, Filmus J, Zacksenhaus E, Zhang Y, Hao X, Ben-David Y. FEBS J. 2018 Dec;285(24):4631-4645. doi: 10.1111/febs.14690. Epub 2018 Nov 20. PubMed |
| Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma. Sade-Feldman M, Yizhak K, Bjorgaard SL, Ray JP, de Boer CG, Jenkins RW, Lieb DJ, Chen JH, Frederick DT, Barzily-Rokni M, Freeman SS, Reuben A, Hoover PJ, Villani AC, Ivanova E, Portell A, Lizotte PH, Aref AR, Eliane JP, Hammond MR, Vitzthum H, Blackmon SM, Li B, Gopalakrishnan V, Reddy SM, Cooper ZA, Paweletz CP, Barbie DA, Stemmer-Rachamimov A, Flaherty KT, Wargo JA, Boland GM, Sullivan RJ, Getz G, Hacohen N. Cell. 2018 Nov 1;175(4):998-1013.e20. doi: 10.1016/j.cell.2018.10.038. PubMed |
| Genomic sequencing and editing revealed the GRM8 signaling pathway as potential therapeutic targets of squamous cell lung cancer. Zhang P, Kang B, Xie G, Li S, Gu Y, Shen Y, Zhao X, Ma Y, Li F, Si J, Wang J, Chen J, Yang H, Xu X, Yang Y. Cancer Lett. 2019 Feb 1;442:53-67. doi: 10.1016/j.canlet.2018.10.035. Epub 2018 Oct 27. PubMed |
| Trichomonas vaginalis Induces NLRP3 Inflammasome Activation and Pyroptotic Cell Death in Human Macrophages. Riestra AM, Valderrama JA, Patras KA, Booth SD, Quek XY, Tsai CM, Nizet V. J Innate Immun. 2019;11(1):86-98. doi: 10.1159/000493585. Epub 2018 Nov 2. PubMed |
| Poly(ADP-ribose) polymerase 1 is necessary for coactivating hypoxia-inducible factor-1-dependent gene expression by Epstein-Barr virus latent membrane protein 1. Hulse M, Caruso LB, Madzo J, Tan Y, Johnson S, Tempera I. PLoS Pathog. 2018 Nov 5;14(11):e1007394. doi: 10.1371/journal.ppat.1007394. eCollection 2018 Nov. PubMed |
| HEXIM1-Tat chimera inhibits HIV-1 replication. Leoz M, Kukanja P, Luo Z, Huang F, Cary DC, Peterlin BM, Fujinaga K. PLoS Pathog. 2018 Nov 5;14(11):e1007402. doi: 10.1371/journal.ppat.1007402. eCollection 2018 Nov. PubMed |
| A single-cell survey of the human first-trimester placenta and decidua. Suryawanshi H, Morozov P, Straus A, Sahasrabudhe N, Max KEA, Garzia A, Kustagi M, Tuschl T, Williams Z. Sci Adv. 2018 Oct 31;4(10):eaau4788. doi: 10.1126/sciadv.aau4788. eCollection 2018 Oct. PubMed |
| Shiga Toxin/Lipopolysaccharide Activates Caspase-4 and Gasdermin D to Trigger Mitochondrial Reactive Oxygen Species Upstream of the NLRP3 Inflammasome. Platnich JM, Chung H, Lau A, Sandall CF, Bondzi-Simpson A, Chen HM, Komada T, Trotman-Grant AC, Brandelli JR, Chun J, Beck PL, Philpott DJ, Girardin SE, Ho M, Johnson RP, MacDonald JA, Armstrong GD, Muruve DA. Cell Rep. 2018 Nov 6;25(6):1525-1536.e7. doi: 10.1016/j.celrep.2018.09.071. PubMed |
| Cell-to-Cell Transmission Is the Main Mechanism Supporting Bovine Viral Diarrhea Virus Spread in Cell Culture. Merwaiss F, Czibener C, Alvarez DE. J Virol. 2019 Jan 17;93(3). pii: JVI.01776-18. doi: 10.1128/JVI.01776-18. Print 2019 Feb 1. PubMed |
| Rab22A recruits BLOC-1 and BLOC-2 to promote the biogenesis of recycling endosomes. Shakya S, Sharma P, Bhatt AM, Jani RA, Delevoye C, Setty SR. EMBO Rep. 2018 Dec;19(12). pii: embr.201845918. doi: 10.15252/embr.201845918. Epub 2018 Nov 7. PubMed |
| A Human Gonadal Cell Model From Induced Pluripotent Stem Cells. Rodriguez Gutierrez D, Eid W, Biason-Lauber A. Front Genet. 2018 Oct 24;9:498. doi: 10.3389/fgene.2018.00498. eCollection 2018. PubMed |
| TRIM59 promotes breast cancer motility by suppressing p62-selective autophagic degradation of PDCD10. Tan P, Ye Y, He L, Xie J, Jing J, Ma G, Pan H, Han L, Han W, Zhou Y. PLoS Biol. 2018 Nov 8;16(11):e3000051. doi: 10.1371/journal.pbio.3000051. eCollection 2018 Nov. PubMed |
| A Whole-genome CRISPR Screen Identifies a Role of MSH2 in Cisplatin-mediated Cell Death in Muscle-invasive Bladder Cancer. Goodspeed A, Jean A, Costello JC. Eur Urol. 2019 Feb;75(2):242-250. doi: 10.1016/j.eururo.2018.10.040. Epub 2018 Nov 7. PubMed |
| Effective Glucose Uptake by Human Astrocytes Requires Its Sequestration in the Endoplasmic Reticulum by Glucose-6-Phosphatase-beta. Muller MS, Fouyssac M, Taylor CW. Curr Biol. 2018 Nov 5;28(21):3481-3486.e4. doi: 10.1016/j.cub.2018.08.060. Epub 2018 Oct 25. PubMed |
| Podoplanin expression is a prognostic biomarker but may be dispensable for the malignancy of glioblastoma. Eisemann T, Costa B, Harter PN, Wick W, Mittelbronn M, Angel P, Peterziel H. Neuro Oncol. 2018 Nov 10. pii: 5168873. doi: 10.1093/neuonc/noy184. PubMed |
| HIV-1 capsids from B27/B57+ elite controllers escape Mx2 but are targeted by TRIM5alpha, leading to the induction of an antiviral state. Merindol N, El-Far M, Sylla M, Masroori N, Dufour C, Li JX, Cherry P, Plourde MB, Tremblay C, Berthoux L. PLoS Pathog. 2018 Nov 12;14(11):e1007398. doi: 10.1371/journal.ppat.1007398. eCollection 2018 Nov. PubMed |
| Estrogen-independent Myc overexpression confers endocrine therapy resistance on breast cancer cells expressing ERalphaY537S and ERalphaD538G mutations. Yu L, Wang L, Mao C, Duraki D, Kim JE, Huang R, Helferich WG, Nelson ER, Park BH, Shapiro DJ. Cancer Lett. 2019 Feb 1;442:373-382. doi: 10.1016/j.canlet.2018.10.041. Epub 2018 Nov 9. PubMed |
| LAT2 regulates glutamine-dependent mTOR activation to promote glycolysis and chemoresistance in pancreatic cancer. Feng M, Xiong G, Cao Z, Yang G, Zheng S, Qiu J, You L, Zheng L, Zhang T, Zhao Y. J Exp Clin Cancer Res. 2018 Nov 12;37(1):274. doi: 10.1186/s13046-018-0947-4. PubMed |
| Predicting Novel Therapies and Targets: Regulation of Notch3 by the Bromodomain Protein BRD4. Villar-Prados A, Wu SY, Court KA, Ma S, LaFargue C, Chowdhury MA, Engelhardt MI, Ivan C, Ram PT, Wang Y, Baggerly K, Rodriguez-Aguayo C, Lopez-Berestein G, Ming-Yang S, Maloney DJ, Yoshioka M, Strovel JW, Roszik J, Sood AK. Mol Cancer Ther. 2019 Feb;18(2):421-436. doi: 10.1158/1535-7163.MCT-18-0365. Epub 2018 Nov 12. PubMed |
| Brain injury induces HIF-1alpha-dependent transcriptional activation of LRRK2 that exacerbates brain damage. Bae YH, Joo H, Bae J, Hyeon SJ, Her S, Ko E, Choi HG, Ryu H, Hur EM, Bu Y, Lee BD. Cell Death Dis. 2018 Nov 12;9(11):1125. doi: 10.1038/s41419-018-1180-y. PubMed |
| Centrosomal protein TRIM43 restricts herpesvirus infection by regulating nuclear lamina integrity. Full F, van Gent M, Sparrer KMJ, Chiang C, Zurenski MA, Scherer M, Brockmeyer NH, Heinzerling L, Sturzl M, Korn K, Stamminger T, Ensser A, Gack MU. Nat Microbiol. 2019 Jan;4(1):164-176. doi: 10.1038/s41564-018-0285-5. Epub 2018 Nov 12. PubMed |
| Fibroblast Growth Factor 2 lethally sensitizes cancer cells to stress-targeted therapeutic inhibitors. Dias MH, Fonseca CS, Zeidler JD, Albuquerque LL, da Silva MS, Cararo-Lopes E, Reis MS, Noel V, Dos Santos EO, Prior IA, Armelin HA. Mol Oncol. 2019 Feb;13(2):290-306. doi: 10.1002/1878-0261.12402. Epub 2018 Dec 3. PubMed |
| PPPDE1 promotes hepatocellular carcinoma development by negatively regulate p53 and apoptosis. Xie X, Wang X, Liao W, Fei R, Wu N, Cong X, Chen Q, Wei L, Wang Y, Chen H. Apoptosis. 2019 Feb;24(1-2):135-144. doi: 10.1007/s10495-018-1491-6. PubMed |
| TP63-Mediated Enhancer Reprogramming Drives the Squamous Subtype of Pancreatic Ductal Adenocarcinoma. Somerville TDD, Xu Y, Miyabayashi K, Tiriac H, Cleary CR, Maia-Silva D, Milazzo JP, Tuveson DA, Vakoc CR. Cell Rep. 2018 Nov 13;25(7):1741-1755.e7. doi: 10.1016/j.celrep.2018.10.051. PubMed |
| Targeted degradation of BRD9 reverses oncogenic gene expression in synovial sarcoma. Brien GL, Remillard D, Shi J, Hemming ML, Chabon J, Wynne K, Dillon ET, Cagney G, Van Mierlo G, Baltissen MP, Vermeulen M, Qi J, Frohling S, Gray NS, Bradner JE, Vakoc CR, Armstrong SA. Elife. 2018 Nov 15;7. pii: 41305. doi: 10.7554/eLife.41305. PubMed |
| HDAC6 differentially regulates autophagy in stem-like versus differentiated cancer cells. Sharif T, Martell E, Dai C, Ghassemi-Rad MS, Hanes MR, Murphy PJ, Margam NN, Parmar HB, Giacomantonio CA, Duncan R, Lee PWK, Gujar S. Autophagy. 2019 Apr;15(4):686-706. doi: 10.1080/15548627.2018.1548547. Epub 2018 Dec 4. PubMed |
| Unique, Intersecting, and Overlapping Roles of C/EBP beta and CREB in Cells of the Innate Immune System. Larabee JL, Hauck G, Ballard JD. Sci Rep. 2018 Nov 16;8(1):16931. doi: 10.1038/s41598-018-35184-y. PubMed |
| Genome-wide CRISPR Screens in Primary Human T Cells Reveal Key Regulators of Immune Function. Shifrut E, Carnevale J, Tobin V, Roth TL, Woo JM, Bui CT, Li PJ, Diolaiti ME, Ashworth A, Marson A. Cell. 2018 Dec 13;175(7):1958-1971.e15. doi: 10.1016/j.cell.2018.10.024. Epub 2018 Nov 15. PubMed |
| Oncogenic Amplification of Zygotic Dux Factors in Regenerating p53-Deficient Muscle Stem Cells Defines a Molecular Cancer Subtype. Preussner J, Zhong J, Sreenivasan K, Gunther S, Engleitner T, Kunne C, Glatzel M, Rad R, Looso M, Braun T, Kim J. Cell Stem Cell. 2018 Dec 6;23(6):794-805.e4. doi: 10.1016/j.stem.2018.10.011. Epub 2018 Nov 15. PubMed |
| Measurement of Force-Sensitive Protein Dynamics in Living Cells Using a Combination of Fluorescent Techniques. Rothenberg KE, Puranam I, Hoffman BD. J Vis Exp. 2018 Nov 2;(141). doi: 10.3791/58619. PubMed |
Lentiviral transduction of mammalian cells for fast, scalable and high-level production of soluble and membrane proteins.
Elegheert J, Behiels E, Bishop B, Scott S, Woolley RE, Griffiths SC, Byrne EFX, Chang VT, Stuart DI, Jones EY, Siebold C, Aricescu AR.
Nat Protoc. 2018 Nov 19. pii: 10.1038/s41596-018-0075-9. doi: 10.1038/s41596-018-0075-9.
PubMed
Associated Plasmids |
| Peptide-based PET quantifies target engagement of PD-L1 therapeutics. Kumar D, Lisok A, Dahmane E, McCoy M, Shelake S, Chatterjee S, Allaj V, Sysa-Shah P, Wharram B, Lesniak WG, Tully E, Gabrielson E, Jaffee EM, Poirier JT, Rudin CM, Gobburu JV, Pomper MG, Nimmagadda S. J Clin Invest. 2019 Feb 1;129(2):616-630. doi: 10.1172/JCI122216. Epub 2019 Jan 7. PubMed |
| Oxidative Stress in Cells with Extra Centrosomes Drives Non-Cell-Autonomous Invasion. Arnandis T, Monteiro P, Adams SD, Bridgeman VL, Rajeeve V, Gadaleta E, Marzec J, Chelala C, Malanchi I, Cutillas PR, Godinho SA. Dev Cell. 2018 Nov 19;47(4):409-424.e9. doi: 10.1016/j.devcel.2018.10.026. PubMed |
| Vascularization and Engraftment of Transplanted Human Cerebral Organoids in Mouse Cortex. Daviaud N, Friedel RH, Zou H. eNeuro. 2018 Nov 20;5(6). pii: eN-NWR-0219-18. doi: 10.1523/ENEURO.0219-18.2018. eCollection 2018 Nov-Dec. PubMed |
| Activation of miR-21-Regulated Pathways in Immune Aging Selects against Signatures Characteristic of Memory T Cells. Kim C, Hu B, Jadhav RR, Jin J, Zhang H, Cavanagh MM, Akondy RS, Ahmed R, Weyand CM, Goronzy JJ. Cell Rep. 2018 Nov 20;25(8):2148-2162.e5. doi: 10.1016/j.celrep.2018.10.074. PubMed |
| Plasminogen Activator Inhibitor-1 Promotes the Recruitment and Polarization of Macrophages in Cancer. Kubala MH, Punj V, Placencio-Hickok VR, Fang H, Fernandez GE, Sposto R, DeClerck YA. Cell Rep. 2018 Nov 20;25(8):2177-2191.e7. doi: 10.1016/j.celrep.2018.10.082. PubMed |
| Transmembrane Protease TMPRSS11B Promotes Lung Cancer Growth by Enhancing Lactate Export and Glycolytic Metabolism. Updegraff BL, Zhou X, Guo Y, Padanad MS, Chen PH, Yang C, Sudderth J, Rodriguez-Tirado C, Girard L, Minna JD, Mishra P, DeBerardinis RJ, O'Donnell KA. Cell Rep. 2018 Nov 20;25(8):2223-2233.e6. doi: 10.1016/j.celrep.2018.10.100. PubMed |
| Protocadherin-1 is essential for cell entry by New World hantaviruses. Jangra RK, Herbert AS, Li R, Jae LT, Kleinfelter LM, Slough MM, Barker SL, Guardado-Calvo P, Roman-Sosa G, Dieterle ME, Kuehne AI, Muena NA, Wirchnianski AS, Nyakatura EK, Fels JM, Ng M, Mittler E, Pan J, Bharrhan S, Wec AZ, Lai JR, Sidhu SS, Tischler ND, Rey FA, Moffat J, Brummelkamp TR, Wang Z, Dye JM, Chandran K. Nature. 2018 Nov;563(7732):559-563. doi: 10.1038/s41586-018-0702-1. Epub 2018 Nov 21. PubMed |
| Repair pathway for PARP-1 DNA-protein crosslinks. Prasad R, Horton JK, Dai DP, Wilson SH. DNA Repair (Amst). 2019 Jan;73:71-77. doi: 10.1016/j.dnarep.2018.11.004. Epub 2018 Nov 12. PubMed |
| Sphingolipid dysregulation due to lack of functional KDSR impairs proplatelet formation causing thrombocytopenia. Bariana TK, Labarque V, Heremans J, Thys C, De Reys M, Greene D, Jenkins B, Grassi L, Seyres D, Burden F, Whitehorn D, Shamardina O, Papadia S, Gomez K, Van Geet C, Koulman A, Ouwehand WH, Ghevaert C, Frontini M, Turro E, Freson K. Haematologica. 2018 Nov 22. pii: haematol.2018.204784. doi: 10.3324/haematol.2018.204784. PubMed |
| Hyperactivation of ERK by multiple mechanisms is toxic to RTK-RAS mutation-driven lung adenocarcinoma cells. Unni AM, Harbourne B, Oh MH, Wild S, Ferrarone JR, Lockwood WW, Varmus H. Elife. 2018 Nov 26;7. pii: 33718. doi: 10.7554/eLife.33718. PubMed |
| LncRNA Meg3 protects endothelial function by regulating the DNA damage response. Shihabudeen Haider Ali MS, Cheng X, Moran M, Haemmig S, Naldrett MJ, Alvarez S, Feinberg MW, Sun X. Nucleic Acids Res. 2018 Nov 22. pii: 5198489. doi: 10.1093/nar/gky1190. PubMed |
| Predicting the mutations generated by repair of Cas9-induced double-strand breaks. Allen F, Crepaldi L, Alsinet C, Strong AJ, Kleshchevnikov V, De Angeli P, Palenikova P, Khodak A, Kiselev V, Kosicki M, Bassett AR, Harding H, Galanty Y, Munoz-Martinez F, Metzakopian E, Jackson SP, Parts L. Nat Biotechnol. 2018 Nov 27. pii: nbt.4317. doi: 10.1038/nbt.4317. PubMed |
| RORalpha controls inflammatory state of human macrophages. Nejati Moharrami N, Bjorkoy Tande E, Ryan L, Espevik T, Boyartchuk V. PLoS One. 2018 Nov 28;13(11):e0207374. doi: 10.1371/journal.pone.0207374. eCollection 2018. PubMed |
| Esrp1-Regulated Splicing of Arhgef11 Isoforms Is Required for Epithelial Tight Junction Integrity. Lee S, Cieply B, Yang Y, Peart N, Glaser C, Chan P, Carstens RP. Cell Rep. 2018 Nov 27;25(9):2417-2430.e5. doi: 10.1016/j.celrep.2018.10.097. PubMed |
| Cis interaction between sialylated FcgammaRIIA and the alphaI-domain of Mac-1 limits antibody-mediated neutrophil recruitment. Saggu G, Okubo K, Chen Y, Vattepu R, Tsuboi N, Rosetti F, Cullere X, Washburn N, Tahir S, Rosado AM, Holland SM, Anthony RM, Sen M, Zhu C, Mayadas TN. Nat Commun. 2018 Nov 29;9(1):5058. doi: 10.1038/s41467-018-07506-1. PubMed |
| Inflammatory Cytokine TNFalpha Promotes the Long-Term Expansion of Primary Hepatocytes in 3D Culture. Peng WC, Logan CY, Fish M, Anbarchian T, Aguisanda F, Alvarez-Varela A, Wu P, Jin Y, Zhu J, Li B, Grompe M, Wang B, Nusse R. Cell. 2018 Nov 29;175(6):1607-1619.e15. doi: 10.1016/j.cell.2018.11.012. PubMed |
| Protein Phosphatase 1 Regulatory Subunit SDS22 Inhibits Breast Cancer Cell Tumorigenesis by Functioning as a Negative Regulator of the AKT Signaling Pathway. Paul D, Bargale AB, Rapole S, Shetty PK, Santra MK. Neoplasia. 2019 Jan;21(1):30-40. doi: 10.1016/j.neo.2018.10.009. Epub 2018 Nov 27. PubMed |
| Interplay between transcription regulators RUNX1 and FUBP1 activates an enhancer of the oncogene c-KIT and amplifies cell proliferation. Debaize L, Jakobczyk H, Avner S, Gaudichon J, Rio AG, Serandour AA, Dorsheimer L, Chalmel F, Carroll JS, Zornig M, Rieger MA, Delalande O, Salbert G, Galibert MD, Gandemer V, Troadec MB. Nucleic Acids Res. 2018 Nov 30;46(21):11214-11228. doi: 10.1093/nar/gky756. PubMed |
| Enhancer Architecture and Essential Core Regulatory Circuitry of Chronic Lymphocytic Leukemia. Ott CJ, Federation AJ, Schwartz LS, Kasar S, Klitgaard JL, Lenci R, Li Q, Lawlor M, Fernandes SM, Souza A, Polaski D, Gadi D, Freedman ML, Brown JR, Bradner JE. Cancer Cell. 2018 Dec 10;34(6):982-995.e7. doi: 10.1016/j.ccell.2018.11.001. Epub 2018 Nov 29. PubMed |
| Studying the Mechanisms of Developmental Vocal Learning and Adult Vocal Performance in Zebra Finches through Lentiviral Injection. Shi Z, Tchernichovski O, Li X. Bio Protoc. 2017 Sep 5;8(17). doi: 10.21769/BioProtoc.3006. PubMed |
| Fungal ligands released by innate immune effectors promote inflammasome activation during Aspergillus fumigatus infection. Briard B, Karki R, Malireddi RKS, Bhattacharya A, Place DE, Mavuluri J, Peters JL, Vogel P, Yamamoto M, Kanneganti TD. Nat Microbiol. 2019 Feb;4(2):316-327. doi: 10.1038/s41564-018-0298-0. Epub 2018 Dec 3. PubMed |
| BCL10-CARD11 Fusion Mimics an Active CARD11 Seed That Triggers Constitutive BCL10 Oligomerization and Lymphocyte Activation. Seeholzer T, Kurz S, Schlauderer F, Woods S, Gehring T, Widmann S, Lammens K, Krappmann D. Front Immunol. 2018 Nov 20;9:2695. doi: 10.3389/fimmu.2018.02695. eCollection 2018. PubMed |
| Ex vivo Culture and Lentiviral Transduction of Benign Prostatic Hyperplasia (BPH) Samples. McClurg UL, McCracken SR, Butler L, Riabowol KT, Binda O. Bio Protoc. 2018 Nov 5;8(21). doi: 10.21769/BioProtoc.3075. PubMed |
| The HDAC-Associated Sin3B Protein Represses DREAM Complex Targets and Cooperates with APC/C to Promote Quiescence. Bainor AJ, Saini S, Calderon A, Casado-Polanco R, Giner-Ramirez B, Moncada C, Cantor DJ, Ernlund A, Litovchick L, David G. Cell Rep. 2018 Dec 4;25(10):2797-2807.e8. doi: 10.1016/j.celrep.2018.11.024. PubMed |
| Exome Sequencing of Drug-Resistant Clones for Target Identification. Han T, Nijhawan D. Methods Mol Biol. 2019;1888:175-187. doi: 10.1007/978-1-4939-8891-4_10. PubMed |
| A virus-packageable CRISPR screen identifies host factors mediating interferon inhibition of HIV. OhAinle M, Helms L, Vermeire J, Roesch F, Humes D, Basom R, Delrow JJ, Overbaugh J, Emerman M. Elife. 2018 Dec 6;7. pii: 39823. doi: 10.7554/eLife.39823. PubMed |
| Interferons Transcriptionally Up-Regulate MLKL Expression in Cancer Cells. Knuth AK, Rosler S, Schenk B, Kowald L, van Wijk SJL, Fulda S. Neoplasia. 2019 Jan;21(1):74-81. doi: 10.1016/j.neo.2018.11.002. Epub 2018 Dec 3. PubMed |
| Inhibition of Membrane-Bound BAFF by the Anti-BAFF Antibody Belimumab. Kowalczyk-Quintas C, Chevalley D, Willen L, Jandus C, Vigolo M, Schneider P. Front Immunol. 2018 Nov 20;9:2698. doi: 10.3389/fimmu.2018.02698. eCollection 2018. PubMed |
| Inhibition of Inflammatory Signaling in Tet2 Mutant Preleukemic Cells Mitigates Stress-Induced Abnormalities and Clonal Hematopoiesis. Cai Z, Kotzin JJ, Ramdas B, Chen S, Nelanuthala S, Palam LR, Pandey R, Mali RS, Liu Y, Kelley MR, Sandusky G, Mohseni M, Williams A, Henao-Mejia J, Kapur R. Cell Stem Cell. 2018 Dec 6;23(6):833-849.e5. doi: 10.1016/j.stem.2018.10.013. PubMed |
| Inhibition of CPAP-tubulin interaction prevents proliferation of centrosome-amplified cancer cells. Mariappan A, Soni K, Schorpp K, Zhao F, Minakar A, Zheng X, Mandad S, Macheleidt I, Ramani A, Kubelka T, Dawidowski M, Golfmann K, Wason A, Yang C, Simons J, Schmalz HG, Hyman AA, Aneja R, Ullrich R, Urlaub H, Odenthal M, Buttner R, Li H, Sattler M, Hadian K, Gopalakrishnan J. EMBO J. 2019 Jan 15;38(2). pii: embj.201899876. doi: 10.15252/embj.201899876. Epub 2018 Dec 10. PubMed |
| Binding of HMGN proteins to cell specific enhancers stabilizes cell identity. He B, Deng T, Zhu I, Furusawa T, Zhang S, Tang W, Postnikov Y, Ambs S, Li CC, Livak F, Landsman D, Bustin M. Nat Commun. 2018 Dec 7;9(1):5240. doi: 10.1038/s41467-018-07687-9. PubMed |
| ATP13A2 facilitates HDAC6 recruitment to lysosome to promote autophagosome-lysosome fusion. Wang R, Tan J, Chen T, Han H, Tian R, Tan Y, Wu Y, Cui J, Chen F, Li J, Lv L, Guan X, Shang S, Lu J, Zhang Z. J Cell Biol. 2019 Jan 7;218(1):267-284. doi: 10.1083/jcb.201804165. Epub 2018 Dec 11. PubMed |
| Human nuclear RNAi-defective 2 (NRDE2) is an essential RNA splicing factor. Jiao AL, Perales R, Umbreit NT, Haswell JR, Piper ME, Adams BD, Pellman D, Kennedy S, Slack FJ. RNA. 2019 Mar;25(3):352-363. doi: 10.1261/rna.069773.118. Epub 2018 Dec 11. PubMed |
| Intersectin-1 interacts with the golgin GCC88 to couple the actin network and Golgi architecture. Makhoul C, Gosavi P, Duffield R, Delbridge B, Williamson NA, Gleeson PA. Mol Biol Cell. 2019 Feb 1;30(3):370-386. doi: 10.1091/mbc.E18-05-0313. Epub 2018 Dec 12. PubMed |
| KLF4, A Gene Regulating Prostate Stem Cell Homeostasis, Is a Barrier to Malignant Progression and Predictor of Good Prognosis in Prostate Cancer. Xiong X, Schober M, Tassone E, Khodadadi-Jamayran A, Sastre-Perona A, Zhou H, Tsirigos A, Shen S, Chang M, Melamed J, Ossowski L, Wilson EL. Cell Rep. 2018 Dec 11;25(11):3006-3020.e7. doi: 10.1016/j.celrep.2018.11.065. PubMed |
| Natural Killer-Derived Exosomal miR-186 Inhibits Neuroblastoma Growth and Immune Escape Mechanisms. Neviani P, Wise PM, Murtadha M, Liu CW, Wu CH, Jong AY, Seeger RC, Fabbri M. Cancer Res. 2019 Mar 15;79(6):1151-1164. doi: 10.1158/0008-5472.CAN-18-0779. Epub 2018 Dec 12. PubMed |
| Insulin-Like Growth Factor 2 Receptor Expression Is Promoted by Human Herpesvirus 8-Encoded Interleukin-6 and Contributes to Viral Latency and Productive Replication. Li Q, Chen D, Xiang Q, Nicholas J. J Virol. 2019 Feb 19;93(5). pii: JVI.02026-18. doi: 10.1128/JVI.02026-18. Print 2019 Mar 1. PubMed |
| Mutagenesis Screens for Prostate Cancer Using Replication-Incompetent Lentiviral Vectors. Trobridge GD. Methods Mol Biol. 2019;1907:103-114. doi: 10.1007/978-1-4939-8967-6_8. PubMed |
| A20 and ABIN1 Suppression of a Keratinocyte Inflammatory Program with a Shared Single-Cell Expression Signature in Diverse Human Rashes. Harirchian P, Lee J, Hilz S, Sedgewick AJ, Perez White BE, Kesling MJ, Mully T, Golovato J, Gray M, Mauro TM, Purdom E, Kim EA, Sbitany H, Bhutani T, Vaske CJ, Benz SC, Cho RJ, Cheng JB. J Invest Dermatol. 2018 Dec 10. pii: S0022-202X(18)32924-5. doi: 10.1016/j.jid.2018.10.046. PubMed |
| Calretinin Functions in Malignant Mesothelioma Cells Cannot Be Replaced by the Closely Related Ca(2+)-Binding Proteins Calbindin-D28k and Parvalbumin. Worthmuller J, Oberson A, Salicio V, Blum W, Schwaller B. Int J Mol Sci. 2018 Dec 12;19(12). pii: ijms19124015. doi: 10.3390/ijms19124015. PubMed |
| The trans-Golgi network is a major site for alpha-secretase processing of amyloid precursor protein in primary neurons. Tan JZA, Gleeson PA. J Biol Chem. 2019 Feb 1;294(5):1618-1631. doi: 10.1074/jbc.RA118.005222. Epub 2018 Dec 13. PubMed |
| New neurons use Slit-Robo signaling to migrate through the glial meshwork and approach a lesion for functional regeneration. Kaneko N, Herranz-Perez V, Otsuka T, Sano H, Ohno N, Omata T, Nguyen HB, Thai TQ, Nambu A, Kawaguchi Y, Garcia-Verdugo JM, Sawamoto K. Sci Adv. 2018 Dec 12;4(12):eaav0618. doi: 10.1126/sciadv.aav0618. eCollection 2018 Dec. PubMed |
| Simultaneous Loss of Both Atypical Protein Kinase C Genes in the Intestinal Epithelium Drives Serrated Intestinal Cancer by Impairing Immunosurveillance. Nakanishi Y, Duran A, L'Hermitte A, Shelton PM, Nakanishi N, Reina-Campos M, Huang J, Soldevila F, Baaten BJG, Tauriello DVF, Castilla EA, Bhangoo MS, Bao F, Sigal D, Diaz-Meco MT, Moscat J. Immunity. 2018 Dec 18;49(6):1132-1147.e7. doi: 10.1016/j.immuni.2018.09.013. Epub 2018 Dec 11. PubMed |
| APOPT1/COA8 assists COX assembly and is oppositely regulated by UPS and ROS. Signes A, Cerutti R, Dickson AS, Beninca C, Hinchy EC, Ghezzi D, Carrozzo R, Bertini E, Murphy MP, Nathan JA, Viscomi C, Fernandez-Vizarra E, Zeviani M. EMBO Mol Med. 2019 Jan;11(1). pii: emmm.201809582. doi: 10.15252/emmm.201809582. PubMed |
| Clathrin-Mediated Endocytosis Regulates a Balance between Opposing Signals to Maintain the Pluripotent State of Embryonic Stem Cells. Narayana YV, Gadgil C, Mote RD, Rajan R, Subramanyam D. Stem Cell Reports. 2019 Jan 8;12(1):152-164. doi: 10.1016/j.stemcr.2018.11.018. Epub 2018 Dec 13. PubMed |
| Layer-by-layer assembled gold nanoshells for the intracellular delivery of miR-34a. Goyal R, Kapadia CH, Melamed JR, Riley RS, Day ES. Cell Mol Bioeng. 2018 Oct;11(5):383-396. doi: 10.1007/s12195-018-0535-x. Epub 2018 Jun 6. PubMed |
| Calretinin promotes invasiveness and EMT in malignant mesothelioma cells involving the activation of the FAK signaling pathway. Worthmuller J, Blum W, Pecze L, Salicio V, Schwaller B. Oncotarget. 2018 Nov 20;9(91):36256-36272. doi: 10.18632/oncotarget.26332. eCollection 2018 Nov 20. PubMed |
| FAM134B induces tumorigenesis and epithelial-to-mesenchymal transition via Akt signaling in hepatocellular carcinoma. Zhang ZQ, Chen J, Huang WQ, Ning D, Liu QM, Wang C, Zhang L, Ren L, Chu L, Liang HF, Fan HN, Zhang BX, Chen XP. Mol Oncol. 2019 Apr;13(4):792-810. doi: 10.1002/1878-0261.12429. Epub 2019 Jan 24. PubMed |
| Prostate transmembrane protein androgen induced 1 is induced by activation of osteoclasts and regulates bone resorption. Xu X, Hirata H, Shiraki M, Kamohara A, Nishioka K, Miyamoto H, Kukita T, Kukita A. FASEB J. 2019 Mar;33(3):4365-4375. doi: 10.1096/fj.201801573R. Epub 2018 Dec 17. PubMed |
Multiplexed orthogonal genome editing and transcriptional activation by Cas12a.
Breinig M, Schweitzer AY, Herianto AM, Revia S, Schaefer L, Wendler L, Cobos Galvez A, Tschaharganeh DF.
Nat Methods. 2019 Jan;16(1):51-54. doi: 10.1038/s41592-018-0262-1. Epub 2018 Dec 17.
PubMed
Associated Plasmids |
| Invasion of white matter tracts by glioma stem cells is regulated by a NOTCH1-SOX2 positive-feedback loop. Wang J, Xu SL, Duan JJ, Yi L, Guo YF, Shi Y, Li L, Yang ZY, Liao XM, Cai J, Zhang YQ, Xiao HL, Yin L, Wu H, Zhang JN, Lv SQ, Yang QK, Yang XJ, Jiang T, Zhang X, Bian XW, Yu SC. Nat Neurosci. 2019 Jan;22(1):91-105. doi: 10.1038/s41593-018-0285-z. Epub 2018 Dec 17. PubMed |
| CRISPR-Mediated Approaches to Regulate YAP/TAZ Levels. Quinton RJ, Ganem NJ. Methods Mol Biol. 2019;1893:203-214. doi: 10.1007/978-1-4939-8910-2_16. PubMed |
| CCNG1 (Cyclin G1) regulation by mutant-P53 via induction of Notch3 expression promotes high-grade serous ovarian cancer (HGSOC) tumorigenesis and progression. Xu Y, Zhang Q, Miao C, Dongol S, Li Y, Jin C, Dong R, Li Y, Yang X, Kong B. Cancer Med. 2019 Jan;8(1):351-362. doi: 10.1002/cam4.1812. Epub 2018 Dec 18. PubMed |
| RNA interference screen identifies NAA10 as a regulator of PXR transcription. Oladimeji PO, Wright WC, Wu J, Chen T. Biochem Pharmacol. 2019 Feb;160:92-109. doi: 10.1016/j.bcp.2018.12.012. Epub 2018 Dec 16. PubMed |
| High PLK4 expression promotes tumor progression and induces epithelialmesenchymal transition by regulating the Wnt/betacatenin signaling pathway in colorectal cancer. Liao Z, Zhang H, Fan P, Huang Q, Dong K, Qi Y, Song J, Chen L, Liang H, Chen X, Zhang Z, Zhang B. Int J Oncol. 2019 Feb;54(2):479-490. doi: 10.3892/ijo.2018.4659. Epub 2018 Dec 10. PubMed |
| Regulation of mitochondrial iron homeostasis by sideroflexin 2. Mon EE, Wei FY, Ahmad RNR, Yamamoto T, Moroishi T, Tomizawa K. J Physiol Sci. 2019 Mar;69(2):359-373. doi: 10.1007/s12576-018-0652-2. Epub 2018 Dec 20. PubMed |
Optimized libraries for CRISPR-Cas9 genetic screens with multiple modalities.
Sanson KR, Hanna RE, Hegde M, Donovan KF, Strand C, Sullender ME, Vaimberg EW, Goodale A, Root DE, Piccioni F, Doench JG.
Nat Commun. 2018 Dec 21;9(1):5416. doi: 10.1038/s41467-018-07901-8.
PubMed
Associated Plasmids
|
| Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis. Tiemann K, Garri C, Lee SB, Malihi PD, Park M, Alvarez RM, Yap LP, Mallick P, Katz JE, Gross ME, Kani K. Oncogene. 2019 Apr;38(16):3003-3018. doi: 10.1038/s41388-018-0638-9. Epub 2018 Dec 21. PubMed |
| Identification of Embryonic Neural Plate Border Stem Cells and Their Generation by Direct Reprogramming from Adult Human Blood Cells. Thier MC, Hommerding O, Panten J, Pinna R, Garcia-Gonzalez D, Berger T, Worsdorfer P, Assenov Y, Scognamiglio R, Przybylla A, Kaschutnig P, Becker L, Milsom MD, Jauch A, Utikal J, Herrmann C, Monyer H, Edenhofer F, Trumpp A. Cell Stem Cell. 2019 Jan 3;24(1):166-182.e13. doi: 10.1016/j.stem.2018.11.015. Epub 2018 Dec 20. PubMed |
| Genome-wide CRISPR Analysis Identifies Substrate-Specific Conjugation Modules in ER-Associated Degradation. Leto DE, Morgens DW, Zhang L, Walczak CP, Elias JE, Bassik MC, Kopito RR. Mol Cell. 2019 Jan 17;73(2):377-389.e11. doi: 10.1016/j.molcel.2018.11.015. Epub 2018 Dec 20. PubMed |
A Compact, High-Accuracy Cas9 with a Dinucleotide PAM for In Vivo Genome Editing.
Edraki A, Mir A, Ibraheim R, Gainetdinov I, Yoon Y, Song CQ, Cao Y, Gallant J, Xue W, Rivera-Perez JA, Sontheimer EJ.
Mol Cell. 2018 Dec 18. pii: S1097-2765(18)31033-5. doi: 10.1016/j.molcel.2018.12.003.
PubMed
Associated Plasmids |
| Inhibition of Dipeptidyl Peptidase-4 Accelerates Epithelial-Mesenchymal Transition and Breast Cancer Metastasis via the CXCL12/CXCR4/mTOR Axis. Yang F, Takagaki Y, Yoshitomi Y, Ikeda T, Li J, Kitada M, Kumagai A, Kawakita E, Shi S, Kanasaki K, Koya D. Cancer Res. 2019 Feb 15;79(4):735-746. doi: 10.1158/0008-5472.CAN-18-0620. Epub 2018 Dec 24. PubMed |
| Anti-Human Rhinovirus 1B Activity of Dexamethasone viaGCR-Dependent Autophagy Activation. Lee JS, Kim SR, Song JH, Lee YP, Ko HJ. Osong Public Health Res Perspect. 2018 Dec;9(6):334-339. doi: 10.24171/j.phrp.2018.9.6.07. PubMed |
| Identification of Novel Protein Targets of Dimethyl Fumarate Modification in Neurons and Astrocytes Reveals Actions Independent of Nrf2 Stabilization. Piroli GG, Manuel AM, Patel T, Walla MD, Shi L, Lanci SA, Wang J, Galloway A, Ortinski PI, Smith DS, Frizzell N. Mol Cell Proteomics. 2019 Mar;18(3):504-519. doi: 10.1074/mcp.RA118.000922. Epub 2018 Dec 26. PubMed |
| Dual Mechanisms of LYN Kinase Dysregulation Drive Aggressive Behavior in Breast Cancer Cells. Tornillo G, Knowlson C, Kendrick H, Cooke J, Mirza H, Aurrekoetxea-Rodriguez I, Vivanco MDM, Buckley NE, Grigoriadis A, Smalley MJ. Cell Rep. 2018 Dec 26;25(13):3674-3692.e10. doi: 10.1016/j.celrep.2018.11.103. PubMed |
Creation of versatile cloning platforms for transgene expression and dCas9-based epigenome editing.
Haldeman JM, Conway AE, Arlotto ME, Slentz DH, Muoio DM, Becker TC, Newgard CB.
Nucleic Acids Res. 2018 Dec 27. pii: 5264291. doi: 10.1093/nar/gky1286.
PubMed
Associated Plasmids |
Alternative 3' UTRs direct localization of functionally diverse protein isoforms in neuronal compartments.
Ciolli Mattioli C, Rom A, Franke V, Imami K, Arrey G, Terne M, Woehler A, Akalin A, Ulitsky I, Chekulaeva M.
Nucleic Acids Res. 2018 Dec 22. pii: 5258023. doi: 10.1093/nar/gky1270.
PubMed
Associated Plasmids |
| Overcoming Challenges of Hepatitis C Virus Envelope Glycoprotein Production in Mammalian Cells. Yost SA, Whidby J, Khan AG, Wang Y, Marcotrigiano J. Methods Mol Biol. 2019;1911:305-316. doi: 10.1007/978-1-4939-8976-8_21. PubMed |
| Inhibition of XPO1 enhances cell death induced by ABT-199 in acute myeloid leukaemia via Mcl-1. Luedtke DA, Su Y, Liu S, Edwards H, Wang Y, Lin H, Taub JW, Ge Y. J Cell Mol Med. 2018 Dec;22(12):6099-6111. doi: 10.1111/jcmm.13886. Epub 2018 Sep 14. PubMed |
| Novel mutations in mevalonate kinase cause disseminated superficial actinic porokeratosis. Zhu T, Tian D, Zhang L, Xu X, Xia K, Hu Z, Xiong Z, Tan J. Br J Dermatol. 2018 Dec 30. doi: 10.1111/bjd.17596. PubMed |
| SG formation relies on eIF4GI-G3BP interaction which is targeted by picornavirus stress antagonists. Yang X, Hu Z, Zhang Q, Fan S, Zhong Y, Guo D, Qin Y, Chen M. Cell Discov. 2019 Jan 1;5:1. doi: 10.1038/s41421-018-0068-4. eCollection 2019. PubMed |
| DHHC4 and DHHC5 Facilitate Fatty Acid Uptake by Palmitoylating and Targeting CD36 to the Plasma Membrane. Wang J, Hao JW, Wang X, Guo H, Sun HH, Lai XY, Liu LY, Zhu M, Wang HY, Li YF, Yu LY, Xie C, Wang HR, Mo W, Zhou HM, Chen S, Liang G, Zhao TJ. Cell Rep. 2019 Jan 2;26(1):209-221.e5. doi: 10.1016/j.celrep.2018.12.022. PubMed |
| SHP2 Drives Adaptive Resistance to ERK Signaling Inhibition in Molecularly Defined Subsets of ERK-Dependent Tumors. Ahmed TA, Adamopoulos C, Karoulia Z, Wu X, Sachidanandam R, Aaronson SA, Poulikakos PI. Cell Rep. 2019 Jan 2;26(1):65-78.e5. doi: 10.1016/j.celrep.2018.12.013. PubMed |
Growth Factor-Independent 1 Is a Tumor Suppressor Gene in Colorectal Cancer.
Chen MS, Lo YH, Chen X, Williams CS, Donnelly JM, Criss ZK 2nd, Patel S, Butkus JM, Dubrulle J, Finegold MJ, Shroyer NF.
Mol Cancer Res. 2019 Mar;17(3):697-708. doi: 10.1158/1541-7786.MCR-18-0666. Epub 2019 Jan 3.
PubMed
Associated Plasmids |
| METTL13 Methylation of eEF1A Increases Translational Output to Promote Tumorigenesis. Liu S, Hausmann S, Carlson SM, Fuentes ME, Francis JW, Pillai R, Lofgren SM, Hulea L, Tandoc K, Lu J, Li A, Nguyen ND, Caporicci M, Kim MP, Maitra A, Wang H, Wistuba II, Porco JA Jr, Bassik MC, Elias JE, Song J, Topisirovic I, Van Rechem C, Mazur PK, Gozani O. Cell. 2019 Jan 24;176(3):491-504.e21. doi: 10.1016/j.cell.2018.11.038. Epub 2019 Jan 3. PubMed |
| Chemically induced vesiculation as a platform for studying TMEM16F activity. Han TW, Ye W, Bethel NP, Zubia M, Kim A, Li KH, Burlingame AL, Grabe M, Jan YN, Jan LY. Proc Natl Acad Sci U S A. 2019 Jan 22;116(4):1309-1318. doi: 10.1073/pnas.1817498116. Epub 2019 Jan 8. PubMed |
| Multicolour In Vivo Bioluminescence Imaging Using a NanoLuc-Based BRET Reporter in Combination with Firefly Luciferase. Taylor A, Sharkey J, Plagge A, Wilm B, Murray P. Contrast Media Mol Imaging. 2018 Dec 3;2018:2514796. doi: 10.1155/2018/2514796. eCollection 2018. PubMed |
| Chromodomain Helicase DNA-Binding Protein 7 Is Suppressed in the Perinecrotic/Ischemic Microenvironment and Is a Novel Regulator of Glioblastoma Angiogenesis. Boyd NH, Walker K, Ayokanmbi A, Gordon ER, Whetsel J, Smith CM, Sanchez RG, Lubin FD, Chakraborty A, Tran AN, Herting C, Hambardzumyan D, Yancey Gillespie G, Hackney JR, Cooper SJ, Jiao K, Hjelmeland AB. Stem Cells. 2019 Apr;37(4):453-462. doi: 10.1002/stem.2969. Epub 2019 Jan 24. PubMed |
| Enhancer Domains in Gastrointestinal Stromal Tumor Regulate KIT Expression and Are Targetable by BET Bromodomain Inhibition. Hemming ML, Lawlor MA, Andersen JL, Hagan T, Chipashvili O, Scott TG, Raut CP, Sicinska E, Armstrong SA, Demetri GD, Bradner JE. Cancer Res. 2019 Mar 1;79(5):994-1009. doi: 10.1158/0008-5472.CAN-18-1888. Epub 2019 Jan 10. PubMed |
CRISPR-Cas9 Circular Permutants as Programmable Scaffolds for Genome Modification.
Oakes BL, Fellmann C, Rishi H, Taylor KL, Ren SM, Nadler DC, Yokoo R, Arkin AP, Doudna JA, Savage DF.
Cell. 2019 Jan 10;176(1-2):254-267.e16. doi: 10.1016/j.cell.2018.11.052.
PubMed
Associated Plasmids |
| Establishment and characterization of an immortalized renal cell line of the Chinese tree shrew (Tupaia belangeri chinesis). Gu T, Yu D, Li Y, Xu L, Yao YL, Yao YG. Appl Microbiol Biotechnol. 2019 Mar;103(5):2171-2180. doi: 10.1007/s00253-019-09615-3. Epub 2019 Jan 12. PubMed |
| TIPE3 is a regulator of cell apoptosis in glioblastoma. Yuan F, Liu B, Xu Y, Li Y, Sun Q, Xu P, Geng R, Den G, Yang J, Zhang S, Gao L, Liao J, Liu J, Yang X, Tan Y, Chen Q. Cancer Lett. 2019 Apr 1;446:1-14. doi: 10.1016/j.canlet.2018.12.019. Epub 2019 Jan 11. PubMed |
| IL-1beta Inflammatory Cytokine-Induced TP63 Isoform NP63alpha Signaling Cascade Contributes to Cisplatin Resistance in Human Breast Cancer Cells. Mendoza-Rodriguez MG, Ayala-Sumuano JT, Garcia-Morales L, Zamudio-Meza H, Perez-Yepez EA, Meza I. Int J Mol Sci. 2019 Jan 11;20(2). pii: ijms20020270. doi: 10.3390/ijms20020270. PubMed |
| Requirement for PRC1 subunit BMI1 in host gene activation by Epstein-Barr virus protein EBNA3C. Paschos K, Bazot Q, Lees J, Farrell PJ, Allday MJ. Nucleic Acids Res. 2019 Jan 15. pii: 5289486. doi: 10.1093/nar/gky1323. PubMed |
| Fever Promotes T Lymphocyte Trafficking via a Thermal Sensory Pathway Involving Heat Shock Protein 90 and alpha4 Integrins. Lin C, Zhang Y, Zhang K, Zheng Y, Lu L, Chang H, Yang H, Yang Y, Wan Y, Wang S, Yuan M, Yan Z, Zhang R, He Y, Ge G, Wu D, Chen J. Immunity. 2019 Jan 15;50(1):137-151.e6. doi: 10.1016/j.immuni.2018.11.013. PubMed |
| Clinical resistance to crenolanib in acute myeloid leukemia due to diverse molecular mechanisms. Zhang H, Savage S, Schultz AR, Bottomly D, White L, Segerdell E, Wilmot B, McWeeney SK, Eide CA, Nechiporuk T, Carlos A, Henson R, Lin C, Searles R, Ho H, Lam YL, Sweat R, Follit C, Jain V, Lind E, Borthakur G, Garcia-Manero G, Ravandi F, Kantarjian HM, Cortes J, Collins R, Buelow DR, Baker SD, Druker BJ, Tyner JW. Nat Commun. 2019 Jan 16;10(1):244. doi: 10.1038/s41467-018-08263-x. PubMed |
| Myosin IIB assembly state determines its mechanosensitive dynamics. Schiffhauer ES, Ren Y, Iglesias VA, Kothari P, Iglesias PA, Robinson DN. J Cell Biol. 2019 Mar 4;218(3):895-908. doi: 10.1083/jcb.201806058. Epub 2019 Jan 17. PubMed |
| Epigenomic profiling of myelofibrosis reveals widespread DNA methylation changes in enhancer elements and ZFP36L1 as a potential tumor suppressor gene that is epigenetically regulated. Martinez-Calle N, Pascual M, Ordonez R, Eneriz ESJ, Kulis M, Miranda E, Guruceaga E, Segura V, Larrayoz MJ, Bellosillo B, Calasanz MJ, Besses C, Rifon J, Martin-Subero JI, Agirre X, Prosper F. Haematologica. 2019 Aug;104(8):1572-1579. doi: 10.3324/haematol.2018.204917. Epub 2019 Jan 17. PubMed |
| The circadian E3 ligase complex SCF(FBXL3+CRY) targets TLK2. Correia SP, Chan AB, Vaughan M, Zolboot N, Perea V, Huber AL, Kriebs A, Moresco JJ, Yates JR 3rd, Lamia KA. Sci Rep. 2019 Jan 17;9(1):198. doi: 10.1038/s41598-018-36618-3. PubMed |
| circRNA of AR-suppressed PABPC1 91 bp enhances the cytotoxicity of natural killer cells against hepatocellular carcinoma via upregulating UL16 binding protein 1. Ma Y, Zhang C, Zhang B, Yu H, Yu Q. Oncol Lett. 2019 Jan;17(1):388-397. doi: 10.3892/ol.2018.9606. Epub 2018 Oct 22. PubMed |
Redundancy of human ATG4 protease isoforms in autophagy and LC3/GABARAP processing revealed in cells.
Agrotis A, Pengo N, Burden JJ, Ketteler R.
Autophagy. 2019 Jan 21. doi: 10.1080/15548627.2019.1569925.
PubMed
Associated Plasmids |
| FOXO3-Engineered Human ESC-Derived Vascular Cells Promote Vascular Protection and Regeneration. Yan P, Li Q, Wang L, Lu P, Suzuki K, Liu Z, Lei J, Li W, He X, Wang S, Ding J, Chan P, Zhang W, Song M, Izpisua Belmonte JC, Qu J, Tang F, Liu GH. Cell Stem Cell. 2019 Mar 7;24(3):447-461.e8. doi: 10.1016/j.stem.2018.12.002. Epub 2019 Jan 17. PubMed |
| Direct in vivo application of induced pluripotent stem cells is feasible and can be safe. Xiang M, Lu M, Quan J, Xu M, Meng D, Cui A, Li N, Liu Y, Lu P, Kang X, Wang X, Sun N, Zhao M, Liang Q, Le L, Wang X, Zhang J, Chen S. Theranostics. 2019 Jan 1;9(1):290-310. doi: 10.7150/thno.28671. eCollection 2019. PubMed |
| The PI3K/AKT signaling pathway regulates ABCG2 expression and confers resistance to chemotherapy in human multiple myeloma. Wang L, Lin N, Li Y. Oncol Rep. 2019 Mar;41(3):1678-1690. doi: 10.3892/or.2019.6968. Epub 2019 Jan 11. PubMed |
| Enhancer hijacking activates oncogenic transcription factor NR4A3 in acinic cell carcinomas of the salivary glands. Haller F, Bieg M, Will R, Korner C, Weichenhan D, Bott A, Ishaque N, Lutsik P, Moskalev EA, Mueller SK, Bahr M, Woerner A, Kaiser B, Scherl C, Haderlein M, Kleinheinz K, Fietkau R, Iro H, Eils R, Hartmann A, Plass C, Wiemann S, Agaimy A. Nat Commun. 2019 Jan 21;10(1):368. doi: 10.1038/s41467-018-08069-x. PubMed |
A genetically encoded near-infrared fluorescent calcium ion indicator.
Qian Y, Piatkevich KD, Mc Larney B, Abdelfattah AS, Mehta S, Murdock MH, Gottschalk S, Molina RS, Zhang W, Chen Y, Wu J, Drobizhev M, Hughes TE, Zhang J, Schreiter ER, Shoham S, Razansky D, Boyden ES, Campbell RE.
Nat Methods. 2019 Feb;16(2):171-174. doi: 10.1038/s41592-018-0294-6. Epub 2019 Jan 21.
PubMed
Associated Plasmids |
| The lysine-specific methyltransferase KMT2C/MLL3 regulates DNA repair components in cancer. Rampias T, Karagiannis D, Avgeris M, Polyzos A, Kokkalis A, Kanaki Z, Kousidou E, Tzetis M, Kanavakis E, Stravodimos K, Manola KN, Pantelias GE, Scorilas A, Klinakis A. EMBO Rep. 2019 Mar;20(3). pii: embr.201846821. doi: 10.15252/embr.201846821. Epub 2019 Jan 21. PubMed |
| MBD3/NuRD loss participates with KDM6A program to promote DOCK5/8 expression and Rac GTPase activation in human acute myeloid leukemia. Biswas M, Chatterjee SS, Boila LD, Chakraborty S, Banerjee D, Sengupta A. FASEB J. 2019 Apr;33(4):5268-5286. doi: 10.1096/fj.201801035R. Epub 2019 Jan 22. PubMed |
| HDAC1 and HDAC2 Double Knockout Triggers Cell Apoptosis in Advanced Thyroid Cancer. Lin CL, Tsai ML, Lin CY, Hsu KW, Hsieh WS, Chi WM, Huang LC, Lee CH. Int J Mol Sci. 2019 Jan 21;20(2). pii: ijms20020454. doi: 10.3390/ijms20020454. PubMed |
| Long non-coding RNA PSMB8-AS1 regulates influenza virus replication. More S, Zhu Z, Lin K, Huang C, Pushparaj S, Liang Y, Sathiaseelan R, Yang X, Liu L. RNA Biol. 2019 Mar;16(3):340-353. doi: 10.1080/15476286.2019.1572448. Epub 2019 Jan 28. PubMed |
| Phosphoglycolate has profound metabolic effects but most likely no role in a metabolic DNA response in cancer cell lines. Gerin I, Bury M, Baldin F, Graff J, Van Schaftingen E, Bommer GT. Biochem J. 2019 Feb 19;476(4):629-643. doi: 10.1042/BCJ20180435. PubMed |
| Gain-of-Function Mutations of SLC16A11 Contribute to the Pathogenesis of Type 2 Diabetes. Zhao Y, Feng Z, Zhang Y, Sun Y, Chen Y, Liu X, Li S, Zhou T, Chen L, Wei Y, Ma D, Lui KO, Ying H, Chen Y, Ding Q. Cell Rep. 2019 Jan 22;26(4):884-892.e4. doi: 10.1016/j.celrep.2018.12.100. PubMed |
| Neuron-Specific Gene 2 (NSG2) Encodes an AMPA Receptor Interacting Protein That Modulates Excitatory Neurotransmission. Chander P, Kennedy MJ, Winckler B, Weick JP. eNeuro. 2019 Jan 24;6(1). pii: eN-NWR-0292-18. doi: 10.1523/ENEURO.0292-18.2018. eCollection 2019 Jan-Feb. PubMed |
| Role of heparan sulfate in the Zika virus entry, replication, and cell death. Gao H, Lin Y, He J, Zhou S, Liang M, Huang C, Li X, Liu C, Zhang P. Virology. 2019 Mar;529:91-100. doi: 10.1016/j.virol.2019.01.019. Epub 2019 Jan 18. PubMed |
| Targeting the Vulnerability of Glutathione Metabolism in ARID1A-Deficient Cancers. Ogiwara H, Takahashi K, Sasaki M, Kuroda T, Yoshida H, Watanabe R, Maruyama A, Makinoshima H, Chiwaki F, Sasaki H, Kato T, Okamoto A, Kohno T. Cancer Cell. 2019 Feb 11;35(2):177-190.e8. doi: 10.1016/j.ccell.2018.12.009. Epub 2019 Jan 24. PubMed |
| Cullin5 deficiency promotes small-cell lung cancer metastasis by stabilizing integrin beta1. Zhao G, Gong L, Su D, Jin Y, Guo C, Yue M, Yao S, Qin Z, Ye Y, Tang Y, Wu Q, Zhang J, Cui B, Ding Q, Huang H, Hu L, Chen Y, Zhang P, Hu G, Chen L, Wong KK, Gao D, Ji H. J Clin Invest. 2019 Mar 1;129(3):972-987. doi: 10.1172/JCI122779. Epub 2019 Jan 28. PubMed |
| Therapeutic efficacy of intra-articular delivery of encapsulated human mesenchymal stem cells on early stage osteoarthritis. McKinney JM, Doan TN, Wang L, Deppen J, Reece DS, Pucha KA, Ginn S, Levit RD, Willett NJ. Eur Cell Mater. 2019 Jan 29;37:42-59. doi: 10.22203/eCM.v037a04. PubMed |
| The EF-Hand Protein CALML6 Suppresses Antiviral Innate Immunity by Impairing IRF3 Dimerization. Wang Z, Sheng C, Yao C, Chen H, Wang D, Chen S. Cell Rep. 2019 Jan 29;26(5):1273-1285.e5. doi: 10.1016/j.celrep.2019.01.030. PubMed |
| Integrated Phosphoproteome and Transcriptome Analysis Reveals Chlamydia-Induced Epithelial-to-Mesenchymal Transition in Host Cells. Zadora PK, Chumduri C, Imami K, Berger H, Mi Y, Selbach M, Meyer TF, Gurumurthy RK. Cell Rep. 2019 Jan 29;26(5):1286-1302.e8. doi: 10.1016/j.celrep.2019.01.006. PubMed |
| Multivalent Role of Human TFIID in Recruiting Elongation Components at the Promoter-Proximal Region for Transcriptional Control. Yadav D, Ghosh K, Basu S, Roeder RG, Biswas D. Cell Rep. 2019 Jan 29;26(5):1303-1317.e7. doi: 10.1016/j.celrep.2019.01.012. PubMed |
| Wild-Type p53 Promotes Cancer Metabolic Switch by Inducing PUMA-Dependent Suppression of Oxidative Phosphorylation. Kim J, Yu L, Chen W, Xu Y, Wu M, Todorova D, Tang Q, Feng B, Jiang L, He J, Chen G, Fu X, Xu Y. Cancer Cell. 2019 Feb 11;35(2):191-203.e8. doi: 10.1016/j.ccell.2018.12.012. Epub 2019 Jan 31. PubMed |
| Pharmacological Targeting of STK19 Inhibits Oncogenic NRAS-Driven Melanomagenesis. Yin C, Zhu B, Zhang T, Liu T, Chen S, Liu Y, Li X, Miao X, Li S, Mi X, Zhang J, Li L, Wei G, Xu ZX, Gao X, Huang C, Wei Z, Goding CR, Wang P, Deng X, Cui R. Cell. 2019 Feb 21;176(5):1113-1127.e16. doi: 10.1016/j.cell.2019.01.002. Epub 2019 Jan 31. PubMed |
| De Novo PITX1 Expression Controls Bi-Stable Transcriptional Circuits to Govern Self-Renewal and Differentiation in Squamous Cell Carcinoma. Sastre-Perona A, Hoang-Phou S, Leitner MC, Okuniewska M, Meehan S, Schober M. Cell Stem Cell. 2019 Mar 7;24(3):390-404.e8. doi: 10.1016/j.stem.2019.01.003. Epub 2019 Jan 31. PubMed |
| F-box protein FBXO16 functions as a tumor suppressor by attenuating nuclear beta-catenin function. Paul D, Islam S, Manne RK, Dinesh US, Malonia SK, Maity B, Boppana R, Rapole S, Shetty PK, Santra MK. J Pathol. 2019 Jul;248(3):266-279. doi: 10.1002/path.5252. Epub 2019 Mar 8. PubMed |
| Ultraviolet B-induced Otx2 expression in lens epithelial cells promotes epithelial-mesenchymal transition. Yoshitomi Y, Osada H, Satake H, Kojima M, Saito-Takatsuji H, Ikeda T, Yoshitake Y, Ishigaki Y, Kubo E, Sasaki H, Yonekura H. Biol Open. 2019 Feb 18;8(2). pii: bio.035691. doi: 10.1242/bio.035691. PubMed |
| CEMIP (KIAA1199) induces a fibrosis-like process in osteoarthritic chondrocytes. Deroyer C, Charlier E, Neuville S, Malaise O, Gillet P, Kurth W, Chariot A, Malaise M, de Seny D. Cell Death Dis. 2019 Feb 4;10(2):103. doi: 10.1038/s41419-019-1377-8. PubMed |
| Label-free Quantitative Analysis of Protein Expression Alterations in miR-26a-Knockout HeLa Cells using SWATH-MS Technology. Shen H, Li L, Teng Z, Meng T, Kong X, Hu Y, Zhu Y, Ma L. Sci Rep. 2019 Feb 4;9(1):1399. doi: 10.1038/s41598-018-34904-8. PubMed |
| Identification of Novel Regulatory Genes in APAP Induced Hepatocyte Toxicity by a Genome-Wide CRISPR-Cas9 Screen. Shortt K, Heruth DP, Zhang N, Wu W, Singh S, Li DY, Zhang LQ, Wyckoff GJ, Qi LS, Friesen CA, Ye SQ. Sci Rep. 2019 Feb 4;9(1):1396. doi: 10.1038/s41598-018-37940-6. PubMed |
| WNT1-inducible signaling pathway protein 1 (WISP1/CCN4) stimulates melanoma invasion and metastasis by promoting the epithelial-mesenchymal transition. Deng W, Fernandez A, McLaughlin SL, Klinke DJ 2nd. J Biol Chem. 2019 Apr 5;294(14):5261-5280. doi: 10.1074/jbc.RA118.006122. Epub 2019 Feb 5. PubMed |
| Targeting NOTCH activation in small cell lung cancer through LSD1 inhibition. Augert A, Eastwood E, Ibrahim AH, Wu N, Grunblatt E, Basom R, Liggitt D, Eaton KD, Martins R, Poirier JT, Rudin CM, Milletti F, Cheng WY, Mack F, MacPherson D. Sci Signal. 2019 Feb 5;12(567). pii: 12/567/eaau2922. doi: 10.1126/scisignal.aau2922. PubMed |
| Tracing cellular heterogeneity in pooled genetic screens via multi-level barcoding. Boettcher M, Covarrubias S, Biton A, Blau J, Wang H, Zaitlen N, McManus MT. BMC Genomics. 2019 Feb 6;20(1):107. doi: 10.1186/s12864-019-5480-0. PubMed |
| Resveratrol enhances pluripotency of mouse embryonic stem cells by activating AMPK/Ulk1 pathway. Suvorova II, Knyazeva AR, Petukhov AV, Aksenov ND, Pospelov VA. Cell Death Discov. 2019 Feb 4;5:61. doi: 10.1038/s41420-019-0137-y. eCollection 2019. PubMed |
| Protein kinase Calpha-mediated phosphorylation of Twist1 at Ser-144 prevents Twist1 ubiquitination and stabilizes it. Tedja R, Roberts CM, Alvero AB, Cardenas C, Yang-Hartwich Y, Spadinger S, Pitruzzello M, Yin G, Glackin CA, Mor G. J Biol Chem. 2019 Mar 29;294(13):5082-5093. doi: 10.1074/jbc.RA118.005921. Epub 2019 Feb 7. PubMed |
| Genome-Scale CRISPR/Cas9 Screening Reveals Squalene Epoxidase as a Susceptibility Factor for Cytotoxicity of Malformin A1. Koizumi Y, Fukushima J, Kobayashi Y, Kadowaki A, Natsui M, Yamaguchi T, Imai Y, Sugiyama T, Kuba K. Chembiochem. 2019 Jun 14;20(12):1563-1568. doi: 10.1002/cbic.201800769. Epub 2019 Apr 18. PubMed |
| Widespread and Functional RNA Circularization in Localized Prostate Cancer. Chen S, Huang V, Xu X, Livingstone J, Soares F, Jeon J, Zeng Y, Hua JT, Petricca J, Guo H, Wang M, Yousif F, Zhang Y, Donmez N, Ahmed M, Volik S, Lapuk A, Chua MLK, Heisler LE, Foucal A, Fox NS, Fraser M, Bhandari V, Shiah YJ, Guan J, Li J, Orain M, Picard V, Hovington H, Bergeron A, Lacombe L, Fradet Y, Tetu B, Liu S, Feng F, Wu X, Shao YW, Komor MA, Sahinalp C, Collins C, Hoogstrate Y, de Jong M, Fijneman RJA, Fei T, Jenster G, van der Kwast T, Bristow RG, Boutros PC, He HH. Cell. 2019 Feb 7;176(4):831-843.e22. doi: 10.1016/j.cell.2019.01.025. PubMed |
| Niclosamide activates the NLRP3 inflammasome by intracellular acidification and mitochondrial inhibition. Thi Tran U, Kitami T. Commun Biol. 2019 Jan 3;2:2. doi: 10.1038/s42003-018-0244-y. eCollection 2019. PubMed |
| Hectd3 promotes pathogenic Th17 lineage through Stat3 activation and Malt1 signaling in neuroinflammation. Cho JJ, Xu Z, Parthasarathy U, Drashansky TT, Helm EY, Zuniga AN, Lorentsen KJ, Mansouri S, Cho JY, Edelmann MJ, Duong DM, Gehring T, Seeholzer T, Krappmann D, Uddin MN, Califano D, Wang RL, Jin L, Li H, Lv D, Zhou D, Zhou L, Avram D. Nat Commun. 2019 Feb 11;10(1):701. doi: 10.1038/s41467-019-08605-3. PubMed |
| Identification of diterpenoid compounds that interfere with Fli-1 DNA binding to suppress leukemogenesis. Liu T, Xia L, Yao Y, Yan C, Fan Y, Gajendran B, Yang J, Li YJ, Chen J, Filmus J, Spaner DE, Zacksenhaus E, Hao X, Ben-David Y. Cell Death Dis. 2019 Feb 11;10(2):117. doi: 10.1038/s41419-019-1363-1. PubMed |
| POH1 contributes to hyperactivation of TGF-beta signaling and facilitates hepatocellular carcinoma metastasis through deubiquitinating TGF-beta receptors and caveolin-1. Wang B, Xu X, Yang Z, Zhang L, Liu Y, Ma A, Xu G, Tang M, Jing T, Wu L, Liu Y. EBioMedicine. 2019 Mar;41:320-332. doi: 10.1016/j.ebiom.2019.01.058. Epub 2019 Feb 7. PubMed |
| Nuclear RNA foci from C9ORF72 expansion mutation form paraspeckle-like bodies. Bajc Cesnik A, Darovic S, Prpar Mihevc S, Stalekar M, Malnar M, Motaln H, Lee YB, Mazej J, Pohleven J, Grosch M, Modic M, Fonovic M, Turk B, Drukker M, Shaw CE, Rogelj B. J Cell Sci. 2019 Mar 7;132(5). pii: jcs.224303. doi: 10.1242/jcs.224303. PubMed |
| Canthin-6-One Accelerates Alpha-Synuclein Degradation by Enhancing UPS Activity: Drug Target Identification by CRISPR-Cas9 Whole Genome-Wide Screening Technology. Yuan NN, Cai CZ, Wu MY, Zhu Q, Su H, Li M, Ren J, Tan JQ, Lu JH. Front Pharmacol. 2019 Jan 28;10:16. doi: 10.3389/fphar.2019.00016. eCollection 2019. PubMed |
| p53 Is a Master Regulator of Proteostasis in SMARCB1-Deficient Malignant Rhabdoid Tumors. Carugo A, Minelli R, Sapio L, Soeung M, Carbone F, Robinson FS, Tepper J, Chen Z, Lovisa S, Svelto M, Amin S, Srinivasan S, Del Poggetto E, Loponte S, Puca F, Dey P, Malouf GG, Su X, Li L, Lopez-Terrada D, Rakheja D, Lazar AJ, Netto GJ, Rao P, Sgambato A, Maitra A, Tripathi DN, Walker CL, Karam JA, Heffernan TP, Viale A, Roberts CWM, Msaouel P, Tannir NM, Draetta GF, Genovese G. Cancer Cell. 2019 Feb 11;35(2):204-220.e9. doi: 10.1016/j.ccell.2019.01.006. PubMed |
| Aging-like Spontaneous Epigenetic Silencing Facilitates Wnt Activation, Stemness, and Braf(V600E)-Induced Tumorigenesis. Tao Y, Kang B, Petkovich DA, Bhandari YR, In J, Stein-O'Brien G, Kong X, Xie W, Zachos N, Maegawa S, Vaidya H, Brown S, Chiu Yen RW, Shao X, Thakor J, Lu Z, Cai Y, Zhang Y, Mallona I, Peinado MA, Zahnow CA, Ahuja N, Fertig E, Issa JP, Baylin SB, Easwaran H. Cancer Cell. 2019 Feb 11;35(2):315-328.e6. doi: 10.1016/j.ccell.2019.01.005. PubMed |
| Human Cytomegalovirus Immediate Early 86-kDa Protein Blocks Transcription and Induces Degradation of the Immature Interleukin-1beta Protein during Virion-Mediated Activation of the AIM2 Inflammasome. Botto S, Abraham J, Mizuno N, Pryke K, Gall B, Landais I, Streblow DN, Fruh KJ, DeFilippis VR. MBio. 2019 Feb 12;10(1). pii: mBio.02510-18. doi: 10.1128/mBio.02510-18. PubMed |
| Experimental and Computational Approaches for Single-Cell Enhancer Perturbation Assay. Xie S, Hon GC. Methods Mol Biol. 2019;1935:203-221. doi: 10.1007/978-1-4939-9057-3_14. PubMed |
| Release of Immunomodulatory Ebola Virus Glycoprotein-Containing Microvesicles Is Suppressed by Tetherin in a Species-Specific Manner. Nehls J, Businger R, Hoffmann M, Brinkmann C, Fehrenbacher B, Schaller M, Maurer B, Schonfeld C, Kramer D, Hailfinger S, Pohlmann S, Schindler M. Cell Rep. 2019 Feb 12;26(7):1841-1853.e6. doi: 10.1016/j.celrep.2019.01.065. PubMed |
| MicroRNA-375 Suppresses the Growth and Invasion of Fibrolamellar Carcinoma. Dinh TA, Jewell ML, Kanke M, Francisco A, Sritharan R, Turnham RE, Lee S, Kastenhuber ER, Wauthier E, Guy CD, Yeung RS, Lowe SW, Reid LM, Scott JD, Diehl AM, Sethupathy P. Cell Mol Gastroenterol Hepatol. 2019;7(4):803-817. doi: 10.1016/j.jcmgh.2019.01.008. Epub 2019 Feb 11. PubMed |
| Heterochromatin anomalies and double-stranded RNA accumulation underlie C9orf72 poly(PR) toxicity. Zhang YJ, Guo L, Gonzales PK, Gendron TF, Wu Y, Jansen-West K, O'Raw AD, Pickles SR, Prudencio M, Carlomagno Y, Gachechiladze MA, Ludwig C, Tian R, Chew J, DeTure M, Lin WL, Tong J, Daughrity LM, Yue M, Song Y, Andersen JW, Castanedes-Casey M, Kurti A, Datta A, Antognetti G, McCampbell A, Rademakers R, Oskarsson B, Dickson DW, Kampmann M, Ward ME, Fryer JD, Link CD, Shorter J, Petrucelli L. Science. 2019 Feb 15;363(6428). pii: 363/6428/eaav2606. doi: 10.1126/science.aav2606. PubMed |
| A poxvirus pseudokinase represses viral DNA replication via a pathway antagonized by its paralog kinase. Olson AT, Wang Z, Rico AB, Wiebe MS. PLoS Pathog. 2019 Feb 15;15(2):e1007608. doi: 10.1371/journal.ppat.1007608. eCollection 2019 Feb. PubMed |
| Bi-allelic Variants in TONSL Cause SPONASTRIME Dysplasia and a Spectrum of Skeletal Dysplasia Phenotypes. Burrage LC, Reynolds JJ, Baratang NV, Phillips JB, Wegner J, McFarquhar A, Higgs MR, Christiansen AE, Lanza DG, Seavitt JR, Jain M, Li X, Parry DA, Raman V, Chitayat D, Chinn IK, Bertuch AA, Karaviti L, Schlesinger AE, Earl D, Bamshad M, Savarirayan R, Doddapaneni H, Muzny D, Jhangiani SN, Eng CM, Gibbs RA, Bi W, Emrick L, Rosenfeld JA, Postlethwait J, Westerfield M, Dickinson ME, Beaudet AL, Ranza E, Huber C, Cormier-Daire V, Shen W, Mao R, Heaney JD, Orange JS, Bertola D, Yamamoto GL, Baratela WAR, Butler MG, Ali A, Adeli M, Cohn DH, Krakow D, Jackson AP, Lees M, Offiah AC, Carlston CM, Carey JC, Stewart GS, Bacino CA, Campeau PM, Lee B. Am J Hum Genet. 2019 Mar 7;104(3):422-438. doi: 10.1016/j.ajhg.2019.01.007. Epub 2019 Feb 14. PubMed |
| Histone Acetyltransferase p300 Induces De Novo Super-Enhancers to Drive Cellular Senescence. Sen P, Lan Y, Li CY, Sidoli S, Donahue G, Dou Z, Frederick B, Chen Q, Luense LJ, Garcia BA, Dang W, Johnson FB, Adams PD, Schultz DC, Berger SL. Mol Cell. 2019 Feb 21;73(4):684-698.e8. doi: 10.1016/j.molcel.2019.01.021. Epub 2019 Feb 14. PubMed |
| Anti-silencing function 1B histone chaperone promotes cell proliferation and migration via activation of the AKT pathway in clear cell renal cell carcinoma. Jiangqiao Z, Tao Q, Zhongbao C, Xiaoxiong M, Long Z, Jilin Z, Tianyu W. Biochem Biophys Res Commun. 2019 Mar 26;511(1):165-172. doi: 10.1016/j.bbrc.2019.02.060. Epub 2019 Feb 15. PubMed |
Fibroblast growth factor receptor influences primary cilium length through an interaction with intestinal cell kinase.
Kunova Bosakova M, Nita A, Gregor T, Varecha M, Gudernova I, Fafilek B, Barta T, Basheer N, Abraham SP, Balek L, Tomanova M, Fialova Kucerova J, Bosak J, Potesil D, Zieba J, Song J, Konik P, Park S, Duran I, Zdrahal Z, Smajs D, Jansen G, Fu Z, Ko HW, Hampl A, Trantirek L, Krakow D, Krejci P.
Proc Natl Acad Sci U S A. 2019 Feb 19. pii: 1800338116. doi: 10.1073/pnas.1800338116.
PubMed
Associated Plasmids |
| Production of High-Titer Lentiviral Particles for Stable Genetic Modification of Mammalian Cells. Larcombe MR, Manent J, Chen J, Mishra K, Liu X, Nefzger CM. Methods Mol Biol. 2019;1940:47-61. doi: 10.1007/978-1-4939-9086-3_4. PubMed |
| A metabolic switch in proteasome inhibitor resistant multiple myeloma ensures higher mitochondrial metabolism, protein folding and sphingomyelin synthesis. Besse L, Besse A, Mendez-Lopez M, Vasickova K, Sedlackova M, Vanhara P, Kraus M, Bader J, Ferreira RB, Castellano RK, Law BK, Driessen C. Haematologica. 2019 Feb 21. pii: haematol.2018.207704. doi: 10.3324/haematol.2018.207704. PubMed |
| Calcium Channel Subunit alpha2delta4 Is Regulated by Early Growth Response 1 and Facilitates Epileptogenesis. van Loo KMJ, Rummel CK, Pitsch J, Muller JA, Bikbaev AF, Martinez-Chavez E, Blaess S, Dietrich D, Heine M, Becker AJ, Schoch S. J Neurosci. 2019 Apr 24;39(17):3175-3187. doi: 10.1523/JNEUROSCI.1731-18.2019. Epub 2019 Feb 21. PubMed |
Pan-Cancer Analyses Reveal Genomic Features of FOXM1 Overexpression in Cancer.
Barger CJ, Branick C, Chee L, Karpf AR.
Cancers (Basel). 2019 Feb 21;11(2). pii: cancers11020251. doi: 10.3390/cancers11020251.
PubMed
Associated Plasmids |
| Protein phosphatase 2A Aalpha regulates Abeta protein expression and stability. O'Connor CM, Hoffa MT, Taylor SE, Avelar RA, Narla G. J Biol Chem. 2019 Apr 12;294(15):5923-5934. doi: 10.1074/jbc.RA119.007593. Epub 2019 Feb 22. PubMed |
| Telomere-dependent and telomere-independent roles of RAP1 in regulating human stem cell homeostasis. Zhang X, Liu Z, Liu X, Wang S, Zhang Y, He X, Sun S, Ma S, Shyh-Chang N, Liu F, Wang Q, Wang X, Liu L, Zhang W, Song M, Liu GH, Qu J. Protein Cell. 2019 Feb 22. pii: 10.1007/s13238-019-0610-7. doi: 10.1007/s13238-019-0610-7. PubMed |
| Targeting an RNA-Binding Protein Network in Acute Myeloid Leukemia. Wang E, Lu SX, Pastore A, Chen X, Imig J, Chun-Wei Lee S, Hockemeyer K, Ghebrechristos YE, Yoshimi A, Inoue D, Ki M, Cho H, Bitner L, Kloetgen A, Lin KT, Uehara T, Owa T, Tibes R, Krainer AR, Abdel-Wahab O, Aifantis I. Cancer Cell. 2019 Mar 18;35(3):369-384.e7. doi: 10.1016/j.ccell.2019.01.010. Epub 2019 Feb 21. PubMed |
| Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion. Harris IS, Endress JE, Coloff JL, Selfors LM, McBrayer SK, Rosenbluth JM, Takahashi N, Dhakal S, Koduri V, Oser MG, Schauer NJ, Doherty LM, Hong AL, Kang YP, Younger ST, Doench JG, Hahn WC, Buhrlage SJ, DeNicola GM, Kaelin WG Jr, Brugge JS. Cell Metab. 2019 May 7;29(5):1166-1181.e6. doi: 10.1016/j.cmet.2019.01.020. Epub 2019 Feb 21. PubMed |
| The Cep57-pericentrin module organizes PCM expansion and centriole engagement. Watanabe K, Takao D, Ito KK, Takahashi M, Kitagawa D. Nat Commun. 2019 Feb 25;10(1):931. doi: 10.1038/s41467-019-08862-2. PubMed |
NFIA is a gliogenic switch enabling rapid derivation of functional human astrocytes from pluripotent stem cells.
Tchieu J, Calder EL, Guttikonda SR, Gutzwiller EM, Aromolaran KA, Steinbeck JA, Goldstein PA, Studer L.
Nat Biotechnol. 2019 Mar;37(3):267-275. doi: 10.1038/s41587-019-0035-0. Epub 2019 Feb 25.
PubMed
Associated Plasmids |
| FBXO22 promotes the development of hepatocellular carcinoma by regulating the ubiquitination and degradation of p21. Zhang L, Chen J, Ning D, Liu Q, Wang C, Zhang Z, Chu L, Yu C, Liang HF, Zhang B, Chen X. J Exp Clin Cancer Res. 2019 Feb 26;38(1):101. doi: 10.1186/s13046-019-1058-6. PubMed |
| Highly Purified Human Extracellular Vesicles Produced by Stem Cells Alleviate Aging Cellular Phenotypes of Senescent Human Cells. Liu S, Mahairaki V, Bai H, Ding Z, Li J, Witwer KW, Cheng L. Stem Cells. 2019 Jun;37(6):779-790. doi: 10.1002/stem.2996. Epub 2019 Mar 12. PubMed |
| Functional Profiling Identifies Determinants of Arsenic Trioxide Cellular Toxicity. Sobh A, Loguinov A, Yazici GN, Zeidan RS, Tagmount A, Hejazi NS, Hubbard AE, Zhang L, Vulpe CD. Toxicol Sci. 2019 May 1;169(1):108-121. doi: 10.1093/toxsci/kfz024. PubMed |
| Unique properties of PTEN-L contribute to neuroprotection in response to ischemic-like stress. Jochner MCE, An J, Lattig-Tunnemann G, Kirchner M, Dagane A, Dittmar G, Dirnagl U, Eickholt BJ, Harms C. Sci Rep. 2019 Feb 28;9(1):3183. doi: 10.1038/s41598-019-39438-1. PubMed |
| High-resolution characterization of centriole distal appendage morphology and dynamics by correlative STORM and electron microscopy. Bowler M, Kong D, Sun S, Nanjundappa R, Evans L, Farmer V, Holland A, Mahjoub MR, Sui H, Loncarek J. Nat Commun. 2019 Mar 1;10(1):993. doi: 10.1038/s41467-018-08216-4. PubMed |
| The stability of Magoh and Y14 depends on their heterodimer formation and nuclear localization. Ma Q, Tatsuno T, Nakamura Y, Ishigaki Y. Biochem Biophys Res Commun. 2019 Apr 9;511(3):631-636. doi: 10.1016/j.bbrc.2019.02.097. Epub 2019 Feb 27. PubMed |
Phosphoinositide Interactions Position cGAS at the Plasma Membrane to Ensure Efficient Distinction between Self- and Viral DNA.
Barnett KC, Coronas-Serna JM, Zhou W, Ernandes MJ, Cao A, Kranzusch PJ, Kagan JC.
Cell. 2019 Mar 7;176(6):1432-1446.e11. doi: 10.1016/j.cell.2019.01.049. Epub 2019 Feb 28.
PubMed
Associated Plasmids |
| BETP degradation simultaneously targets acute myelogenous leukemia stem cells and the microenvironment. Piya S, Mu H, Bhattacharya S, Lorenzi PL, Davis RE, McQueen T, Ruvolo V, Baran N, Wang Z, Qian Y, Crews CM, Konopleva M, Ishizawa J, You MJ, Kantarjian H, Andreeff M, Borthakur G. J Clin Invest. 2019 Feb 21;129(5):1878-1894. doi: 10.1172/JCI120654. Print 2019 May 1. PubMed |
| Base editing the mammalian genome. Schatoff EM, Zafra MP, Dow LE. Methods. 2019 Jul 15;164-165:100-108. doi: 10.1016/j.ymeth.2019.02.022. Epub 2019 Mar 2. PubMed |
| Circular synthesized CRISPR/Cas gRNAs for functional interrogations in the coding and noncoding genome. Wegner M, Diehl V, Bittl V, de Bruyn R, Wiechmann S, Matthess Y, Hebel M, Hayes MG, Schaubeck S, Benner C, Heinz S, Bremm A, Dikic I, Ernst A, Kaulich M. Elife. 2019 Mar 6;8. pii: 42549. doi: 10.7554/eLife.42549. PubMed |
| FMR1 Reactivating Treatments in Fragile X iPSC-Derived Neural Progenitors In Vitro and In Vivo. Vershkov D, Fainstein N, Suissa S, Golan-Lev T, Ben-Hur T, Benvenisty N. Cell Rep. 2019 Mar 5;26(10):2531-2539.e4. doi: 10.1016/j.celrep.2019.02.026. PubMed |
| Human Pluripotent Stem Cell-Derived Tumor Model Uncovers the Embryonic Stem Cell Signature as a Key Driver in Atypical Teratoid/Rhabdoid Tumor. Terada Y, Jo N, Arakawa Y, Sakakura M, Yamada Y, Ukai T, Kabata M, Mitsunaga K, Mineharu Y, Ohta S, Nakagawa M, Miyamoto S, Yamamoto T, Yamada Y. Cell Rep. 2019 Mar 5;26(10):2608-2621.e6. doi: 10.1016/j.celrep.2019.02.009. PubMed |
| MicroRNA-Mediated Suppression of the TGF-beta Pathway Confers Transmissible and Reversible CDK4/6 Inhibitor Resistance. Cornell L, Wander SA, Visal T, Wagle N, Shapiro GI. Cell Rep. 2019 Mar 5;26(10):2667-2680.e7. doi: 10.1016/j.celrep.2019.02.023. PubMed |
| Myeloid Folliculin balances mTOR activation to maintain innate immunity homeostasis. Li J, Wada S, Weaver LK, Biswas C, Behrens EM, Arany Z. JCI Insight. 2019 Mar 7;5. pii: 126939. doi: 10.1172/jci.insight.126939. PubMed |
| Genome-wide screening identifies novel genes and biological processes implicated in cisplatin resistance. Ko T, Li S. FASEB J. 2019 Jun;33(6):7143-7154. doi: 10.1096/fj.201801534RR. Epub 2019 Mar 7. PubMed |
| TZAP plays an inhibitory role in the self-renewal of porcine mesenchymal stromal cells and is implicated the regulation of premature senescence via the p53 pathway. Bie YN, Gu P, Chen YT, Zhou XX, Tian YG, Yang Q, Li HY, Lin X, Guan YH, Lin TY, Lu X, Shen HF, Fang TX, Liu YM, Xiao D, Gu WW. J Transl Med. 2019 Mar 7;17(1):72. doi: 10.1186/s12967-019-1820-8. PubMed |
| Induction of Potent Neutralizing Antibody Responses by a Designed Protein Nanoparticle Vaccine for Respiratory Syncytial Virus. Marcandalli J, Fiala B, Ols S, Perotti M, de van der Schueren W, Snijder J, Hodge E, Benhaim M, Ravichandran R, Carter L, Sheffler W, Brunner L, Lawrenz M, Dubois P, Lanzavecchia A, Sallusto F, Lee KK, Veesler D, Correnti CE, Stewart LJ, Baker D, Lore K, Perez L, King NP. Cell. 2019 Mar 7;176(6):1420-1431.e17. doi: 10.1016/j.cell.2019.01.046. PubMed |
| LAMB3 mediates apoptotic, proliferative, invasive, and metastatic behaviors in pancreatic cancer by regulating the PI3K/Akt signaling pathway. Zhang H, Pan YZ, Cheung M, Cao M, Yu C, Chen L, Zhan L, He ZW, Sun CY. Cell Death Dis. 2019 Mar 8;10(3):230. doi: 10.1038/s41419-019-1320-z. PubMed |
Innate Immune Signaling Organelles Display Natural and Programmable Signaling Flexibility.
Tan Y, Kagan JC.
Cell. 2019 Apr 4;177(2):384-398.e11. doi: 10.1016/j.cell.2019.01.039. Epub 2019 Mar 7.
PubMed
Associated Plasmids |
| MAP4K4 Inhibition Promotes Survival of Human Stem Cell-Derived Cardiomyocytes and Reduces Infarct Size In Vivo. Fiedler LR, Chapman K, Xie M, Maifoshie E, Jenkins M, Golforoush PA, Bellahcene M, Noseda M, Faust D, Jarvis A, Newton G, Paiva MA, Harada M, Stuckey DJ, Song W, Habib J, Narasimhan P, Aqil R, Sanmugalingam D, Yan R, Pavanello L, Sano M, Wang SC, Sampson RD, Kanayaganam S, Taffet GE, Michael LH, Entman ML, Tan TH, Harding SE, Low CMR, Tralau-Stewart C, Perrior T, Schneider MD. Cell Stem Cell. 2019 Apr 4;24(4):579-591.e12. doi: 10.1016/j.stem.2019.01.013. Epub 2019 Mar 7. PubMed |
| Cognate Interaction With CD4(+) T Cells Instructs Tumor-Associated Macrophages to Acquire M1-Like Phenotype. Eisel D, Das K, Dickes E, Konig R, Osen W, Eichmuller SB. Front Immunol. 2019 Feb 22;10:219. doi: 10.3389/fimmu.2019.00219. eCollection 2019. PubMed |
| A KLF6-driven transcriptional network links lipid homeostasis and tumour growth in renal carcinoma. Syafruddin SE, Rodrigues P, Vojtasova E, Patel SA, Zaini MN, Burge J, Warren AY, Stewart GD, Eisen T, Bihary D, Samarajiwa SA, Vanharanta S. Nat Commun. 2019 Mar 11;10(1):1152. doi: 10.1038/s41467-019-09116-x. PubMed |
| Kaiso is required for MTG16-dependent effects on colitis-associated carcinoma. Short SP, Barrett CW, Stengel KR, Revetta FL, Choksi YA, Coburn LA, Lintel MK, McDonough EM, Washington MK, Wilson KT, Prokhortchouk E, Chen X, Hiebert SW, Reynolds AB, Williams CS. Oncogene. 2019 Jun;38(25):5091-5106. doi: 10.1038/s41388-019-0777-7. Epub 2019 Mar 11. PubMed |
| Replication Study: The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44. Yan X, Tang B, Chen B, Shan Y, Yang H, Iorns E, Tsui R, Denis A, Perfito N, Errington TM. Elife. 2019 Mar 12;8. pii: 43511. doi: 10.7554/eLife.43511. PubMed |
| A complex between DYRK1A and DCAF7 phosphorylates the C-terminal domain of RNA polymerase II to promote myogenesis. Yu D, Cattoglio C, Xue Y, Zhou Q. Nucleic Acids Res. 2019 May 21;47(9):4462-4475. doi: 10.1093/nar/gkz162. PubMed |
| Integrin alpha6beta4E variant is associated with actin and CD9 structures and modifies the biophysical properties of cell-cell and cell-extracellular matrix interactions. Wang M, Hinton JP, Gard JMC, Garcia JGN, Knudsen BS, Nagle RB, Cress AE. Mol Biol Cell. 2019 Mar 21;30(7):838-850. doi: 10.1091/mbc.E18-10-0652. Epub 2019 Mar 13. PubMed |
| The lncRNA TP73-AS1 is linked to aggressiveness in glioblastoma and promotes temozolomide resistance in glioblastoma cancer stem cells. Mazor G, Levin L, Picard D, Ahmadov U, Caren H, Borkhardt A, Reifenberger G, Leprivier G, Remke M, Rotblat B. Cell Death Dis. 2019 Mar 13;10(3):246. doi: 10.1038/s41419-019-1477-5. PubMed |
| TFEB-driven lysosomal biogenesis is pivotal for PGC1alpha-dependent renal stress resistance. Lynch MR, Tran MT, Ralto KM, Zsengeller ZK, Raman V, Bhasin SS, Sun N, Chen X, Brown D, Rovira II, Taguchi K, Brooks CR, Stillman IE, Bhasin MK, Finkel T, Parikh SM. JCI Insight. 2019 Mar 14;5. pii: 126749. doi: 10.1172/jci.insight.126749. PubMed |
| Rapid and reversible suppression of ALT by DAXX in osteosarcoma cells. Yost KE, Clatterbuck Soper SF, Walker RL, Pineda MA, Zhu YJ, Ester CD, Showman S, Roschke AV, Waterfall JJ, Meltzer PS. Sci Rep. 2019 Mar 14;9(1):4544. doi: 10.1038/s41598-019-41058-8. PubMed |
| EZH2 Inhibition in Ewing Sarcoma Upregulates GD2 Expression for Targeting with Gene-Modified T Cells. Kailayangiri S, Altvater B, Lesch S, Balbach S, Gottlich C, Kuhnemundt J, Mikesch JH, Schelhaas S, Jamitzky S, Meltzer J, Farwick N, Greune L, Fluegge M, Kerl K, Lode HN, Siebert N, Muller I, Walles H, Hartmann W, Rossig C. Mol Ther. 2019 May 8;27(5):933-946. doi: 10.1016/j.ymthe.2019.02.014. Epub 2019 Feb 23. PubMed |
Single-Cell Proteomics Reveal that Quantitative Changes in Co-expressed Lineage-Specific Transcription Factors Determine Cell Fate.
Palii CG, Cheng Q, Gillespie MA, Shannon P, Mazurczyk M, Napolitani G, Price ND, Ranish JA, Morrissey E, Higgs DR, Brand M.
Cell Stem Cell. 2019 May 2;24(5):812-820.e5. doi: 10.1016/j.stem.2019.02.006. Epub 2019 Mar 14.
PubMed
Associated Plasmids |
| The TLR4 adaptor TRAM controls the phagocytosis of Gram-negative bacteria by interacting with the Rab11-family interacting protein 2. Skjesol A, Yurchenko M, Bosl K, Gravastrand C, Nilsen KE, Grovdal LM, Agliano F, Patane F, Lentini G, Kim H, Teti G, Kumar Sharma A, Kandasamy RK, Sporsheim B, Starheim KK, Golenbock DT, Stenmark H, McCaffrey M, Espevik T, Husebye H. PLoS Pathog. 2019 Mar 18;15(3):e1007684. doi: 10.1371/journal.ppat.1007684. eCollection 2019 Mar. PubMed |
| Logic-Gated ROR1 Chimeric Antigen Receptor Expression Rescues T Cell-Mediated Toxicity to Normal Tissues and Enables Selective Tumor Targeting. Srivastava S, Salter AI, Liggitt D, Yechan-Gunja S, Sarvothama M, Cooper K, Smythe KS, Dudakov JA, Pierce RH, Rader C, Riddell SR. Cancer Cell. 2019 Mar 18;35(3):489-503.e8. doi: 10.1016/j.ccell.2019.02.003. PubMed |
| DNA Replication Vulnerabilities Render Ovarian Cancer Cells Sensitive to Poly(ADP-Ribose) Glycohydrolase Inhibitors. Pillay N, Tighe A, Nelson L, Littler S, Coulson-Gilmer C, Bah N, Golder A, Bakker B, Spierings DCJ, James DI, Smith KM, Jordan AM, Morgan RD, Ogilvie DJ, Foijer F, Jackson DA, Taylor SS. Cancer Cell. 2019 Mar 18;35(3):519-533.e8. doi: 10.1016/j.ccell.2019.02.004. PubMed |
| HIPK2 is necessary for type I interferon-mediated antiviral immunity. Cao L, Yang G, Gao S, Jing C, Montgomery RR, Yin Y, Wang P, Fikrig E, You F. Sci Signal. 2019 Mar 19;12(573). pii: 12/573/eaau4604. doi: 10.1126/scisignal.aau4604. PubMed |
| Chronic optogenetic induction of stress granules is cytotoxic and reveals the evolution of ALS-FTD pathology. Zhang P, Fan B, Yang P, Temirov J, Messing J, Kim HJ, Taylor JP. Elife. 2019 Mar 20;8. pii: 39578. doi: 10.7554/eLife.39578. PubMed |
| Negative Regulation of p53-Induced Senescence by N-WASP Is Crucial for DMBA/TPA-Induced Skin Tumor Formation. Li H, Petersen S, Garcia Mariscal A, Brakebusch C. Cancer Res. 2019 May 1;79(9):2167-2181. doi: 10.1158/0008-5472.CAN-18-1253. Epub 2019 Mar 20. PubMed |
A reference collection of patient-derived cell line and xenograft models of proneural, classical and mesenchymal glioblastoma.
Stringer BW, Day BW, D'Souza RCJ, Jamieson PR, Ensbey KS, Bruce ZC, Lim YC, Goasdoue K, Offenhauser C, Akgul S, Allan S, Robertson T, Lucas P, Tollesson G, Campbell S, Winter C, Do H, Dobrovic A, Inglis PL, Jeffree RL, Johns TG, Boyd AW.
Sci Rep. 2019 Mar 20;9(1):4902. doi: 10.1038/s41598-019-41277-z.
PubMed
Associated Plasmids |
| Genome-wide CRISPR screen reveals PSMA6 to be an essential gene in pancreatic cancer cells. Bakke J, Wright WC, Zamora AE, Oladimeji P, Crawford JC, Brewer CT, Autry RJ, Evans WE, Thomas PG, Chen T. BMC Cancer. 2019 Mar 21;19(1):253. doi: 10.1186/s12885-019-5455-1. PubMed |
Induced Neurons for the Study of Neurodegenerative and Neurodevelopmental Disorders.
Sauter EJ, Kutsche LK, Klapper SD, Busskamp V.
Methods Mol Biol. 2019;1942:101-121. doi: 10.1007/978-1-4939-9080-1_9.
PubMed
Associated Plasmids |
| Characterization of the ERG-regulated Kinome in Prostate Cancer Identifies TNIK as a Potential Therapeutic Target. Lee RS, Zhang L, Berger A, Lawrence MG, Song J, Niranjan B, Davies RG, Lister NL, Sandhu SK, Rubin MA, Risbridger GP, Taylor RA, Rickman DS, Horvath LG, Daly RJ. Neoplasia. 2019 Apr;21(4):389-400. doi: 10.1016/j.neo.2019.02.005. Epub 2019 Mar 20. PubMed |
| WNT3a and WNT5a Transported by Exosomes Activate WNT Signaling Pathways in Human Cardiac Fibroblasts. Dzialo E, Rudnik M, Koning RI, Czepiel M, Tkacz K, Baj-Krzyworzeka M, Distler O, Siedlar M, Kania G, Blyszczuk P. Int J Mol Sci. 2019 Mar 21;20(6). pii: ijms20061436. doi: 10.3390/ijms20061436. PubMed |
| Elevated Heme Synthesis and Uptake Underpin Intensified Oxidative Metabolism and Tumorigenic Functions in Non-Small Cell Lung Cancer Cells. Sohoni S, Ghosh P, Wang T, Kalainayakan SP, Vidal C, Dey S, Konduri PC, Zhang L. Cancer Res. 2019 May 15;79(10):2511-2525. doi: 10.1158/0008-5472.CAN-18-2156. Epub 2019 Mar 22. PubMed |
| Substrate mechanics controls adipogenesis through YAP phosphorylation by dictating cell spreading. Oliver-De La Cruz J, Nardone G, Vrbsky J, Pompeiano A, Perestrelo AR, Capradossi F, Melajova K, Filipensky P, Forte G. Biomaterials. 2019 Jun;205:64-80. doi: 10.1016/j.biomaterials.2019.03.009. Epub 2019 Mar 16. PubMed |
| Exome Sequencing of ABCB5 Identifies Recurrent Melanoma Mutations that Result in Increased Proliferative and Invasive Capacities. Sana G, Madigan JP, Gartner JJ, Fourrez M, Lin J, Qutob N, Narayan J, Shukla S, Ambudkar SV, Xia D, Rosenberg SA, Gottesman MM, Samuels Y, Gillet JP. J Invest Dermatol. 2019 Mar 21. pii: S0022-202X(19)31330-2. doi: 10.1016/j.jid.2019.01.036. PubMed |
| Maintenance of Nucleolar Homeostasis by CBX4 Alleviates Senescence and Osteoarthritis. Ren X, Hu B, Song M, Ding Z, Dang Y, Liu Z, Zhang W, Ji Q, Ren R, Ding J, Chan P, Jiang C, Ye K, Qu J, Tang F, Liu GH. Cell Rep. 2019 Mar 26;26(13):3643-3656.e7. doi: 10.1016/j.celrep.2019.02.088. PubMed |
| Atheroprotective Flow Upregulates ITPR3 (Inositol 1,4,5-Trisphosphate Receptor 3) in Vascular Endothelium via KLF4 (Kruppel-Like Factor 4)-Mediated Histone Modifications. He M, Huang TS, Li S, Hong HC, Chen Z, Martin M, Zhou X, Huang HY, Su SH, Zhang J, Wang WT, Kang J, Huang HD, Zhang J, Chien S, Shyy JY. Arterioscler Thromb Vasc Biol. 2019 May;39(5):902-914. doi: 10.1161/ATVBAHA.118.312301. PubMed |
| Combined Transcriptome and Proteome Analysis of Immortalized Human Keratinocytes Expressing Human Papillomavirus 16 (HPV16) Oncogenes Reveals Novel Key Factors and Networks in HPV-Induced Carcinogenesis. Yang R, Klimentova J, Gockel-Krzikalla E, Ly R, Gmelin N, Hotz-Wagenblatt A, Rehulkova H, Stulik J, Rosl F, Niebler M. mSphere. 2019 Mar 27;4(2). pii: 4/2/e00129-19. doi: 10.1128/mSphere.00129-19. PubMed |
| Syndecan 1 is a critical mediator of macropinocytosis in pancreatic cancer. Yao W, Rose JL, Wang W, Seth S, Jiang H, Taguchi A, Liu J, Yan L, Kapoor A, Hou P, Chen Z, Wang Q, Nezi L, Xu Z, Yao J, Hu B, Pettazzoni PF, Ho IL, Feng N, Ramamoorthy V, Jiang S, Deng P, Ma GJ, Den P, Tan Z, Zhang SX, Wang H, Wang YA, Deem AK, Fleming JB, Carugo A, Heffernan TP, Maitra A, Viale A, Ying H, Hanash S, DePinho RA, Draetta GF. Nature. 2019 Apr;568(7752):410-414. doi: 10.1038/s41586-019-1062-1. Epub 2019 Mar 27. PubMed |
| Chemokine (C-X-C motif) ligand 14 contributes to lipopolysaccharide-induced fibrogenesis in mouse L929 fibroblasts via modulating PPM1A. Li L, Li Q, Wei L, Wang Z, Ma W, Liu F, Shen Y, Zhang S, Zhang X, Li H, Qian Y. J Cell Biochem. 2019 Aug;120(8):13372-13381. doi: 10.1002/jcb.28612. Epub 2019 Mar 28. PubMed |
| Sex determining region Y-box 12 (SOX12) promotes gastric cancer metastasis by upregulating MMP7 and IGF1. Du F, Feng W, Chen S, Wu S, Cao T, Yuan T, Tian D, Nie Y, Wu K, Fan D, Xia L. Cancer Lett. 2019 Jun 28;452:103-118. doi: 10.1016/j.canlet.2019.03.035. Epub 2019 Mar 25. PubMed |
| The homophilic receptor PTPRK selectively dephosphorylates multiple junctional regulators to promote cell-cell adhesion. Fearnley GW, Young KA, Edgar JR, Antrobus R, Hay IM, Liang WC, Martinez-Martin N, Lin W, Deane JE, Sharpe HJ. Elife. 2019 Mar 29;8. pii: 44597. doi: 10.7554/eLife.44597. PubMed |
| Progesterone receptor isoform B expression in pulmonary neuroendocrine cells decreases cell proliferation. Asavasupreechar T, Saito R, Edwards DP, Sasano H, Boonyaratanakornkit V. J Steroid Biochem Mol Biol. 2019 Jun;190:212-223. doi: 10.1016/j.jsbmb.2019.03.022. Epub 2019 Mar 26. PubMed |
| MYC Recruits SPT5 to RNA Polymerase II to Promote Processive Transcription Elongation. Baluapuri A, Hofstetter J, Dudvarski Stankovic N, Endres T, Bhandare P, Vos SM, Adhikari B, Schwarz JD, Narain A, Vogt M, Wang SY, Duster R, Jung LA, Vanselow JT, Wiegering A, Geyer M, Maric HM, Gallant P, Walz S, Schlosser A, Cramer P, Eilers M, Wolf E. Mol Cell. 2019 May 16;74(4):674-687.e11. doi: 10.1016/j.molcel.2019.02.031. Epub 2019 Mar 27. PubMed |
| CRISPR screening using an expanded toolkit of autophagy reporters identifies TMEM41B as a novel autophagy factor. Shoemaker CJ, Huang TQ, Weir NR, Polyakov NJ, Schultz SW, Denic V. PLoS Biol. 2019 Apr 1;17(4):e2007044. doi: 10.1371/journal.pbio.2007044. eCollection 2019 Apr. PubMed |
| Up-regulation of FOXD1 by YAP alleviates senescence and osteoarthritis. Fu L, Hu Y, Song M, Liu Z, Zhang W, Yu FX, Wu J, Wang S, Izpisua Belmonte JC, Chan P, Qu J, Tang F, Liu GH. PLoS Biol. 2019 Apr 1;17(4):e3000201. doi: 10.1371/journal.pbio.3000201. eCollection 2019 Apr. PubMed |
| Myristoylated alanine-rich C-kinase substrate effector domain phosphorylation regulates the growth and radiation sensitization of glioblastoma. Eustace NJ, Anderson JC, Langford CP, Trummell HQ, Hicks PH, Jarboe JS, Mobley JA, Hjelmeland AB, Hackney JR, Pedersen RT, Cosby K, Gillespie GY, Bonner JA, Willey CD. Int J Oncol. 2019 Jun;54(6):2039-2053. doi: 10.3892/ijo.2019.4766. Epub 2019 Mar 29. PubMed |
| Transcriptional Circuit Fragility Influences HIV Proviral Fate. Morton EL, Forst CV, Zheng Y, DePaula-Silva AB, Ramirez NP, Planelles V, D'Orso I. Cell Rep. 2019 Apr 2;27(1):154-171.e9. doi: 10.1016/j.celrep.2019.03.007. PubMed |
| Functional analysis of the secondary HIV-1 capsid binding site in the host protein cyclophilin A. Peng W, Shi J, Marquez CL, Lau D, Walsh J, Faysal KMR, Byeon CH, Byeon IL, Aiken C, Bocking T. Retrovirology. 2019 Apr 4;16(1):10. doi: 10.1186/s12977-019-0471-4. PubMed |
| Silencing an insulin-induced lncRNA, LncASIR, impairs the transcriptional response to insulin signalling in adipocytes. Degirmenci U, Li J, Lim YC, Siang DTC, Lin S, Liang H, Sun L. Sci Rep. 2019 Apr 4;9(1):5608. doi: 10.1038/s41598-019-42162-5. PubMed |
| Unique features in the intracellular transport of typhoid toxin revealed by a genome-wide screen. Chang SJ, Jin SC, Jiao X, Galan JE. PLoS Pathog. 2019 Apr 5;15(4):e1007704. doi: 10.1371/journal.ppat.1007704. eCollection 2019 Apr. PubMed |
| Yin Yang 1 Orchestrates a Metabolic Program Required for Both Neural Crest Development and Melanoma Formation. Varum S, Baggiolini A, Zurkirchen L, Atak ZK, Cantu C, Marzorati E, Bossart R, Wouters J, Hausel J, Tuncer E, Zingg D, Veen D, John N, Balz M, Levesque MP, Basler K, Aerts S, Zamboni N, Dummer R, Sommer L. Cell Stem Cell. 2019 Apr 4;24(4):637-653.e9. doi: 10.1016/j.stem.2019.03.011. PubMed |
| ATG2 transports lipids to promote autophagosome biogenesis. Valverde DP, Yu S, Boggavarapu V, Kumar N, Lees JA, Walz T, Reinisch KM, Melia TJ. J Cell Biol. 2019 Jun 3;218(6):1787-1798. doi: 10.1083/jcb.201811139. Epub 2019 Apr 5. PubMed |
Wide-area all-optical neurophysiology in acute brain slices.
Farhi SL, Parot VJ, Grama A, Yamagata M, Abdelfattah AS, Adam Y, Lou S, Jun Kim J, Campbell RE, Cox DD, Cohen AE.
J Neurosci. 2019 Apr 5. pii: JNEUROSCI.0168-19.2019. doi: 10.1523/JNEUROSCI.0168-19.2019.
PubMed
Associated Plasmids |
| Depletion of PD-1-positive cells ameliorates autoimmune disease. Zhao P, Wang P, Dong S, Zhou Z, Cao Y, Yagita H, He X, Zheng SG, Fisher SJ, Fujinami RS, Chen M. Nat Biomed Eng. 2019 Apr;3(4):292-305. doi: 10.1038/s41551-019-0360-0. Epub 2019 Mar 4. PubMed |
| Transmembrane 4 L Six Family Member 5 Senses Arginine for mTORC1 Signaling. Jung JW, Macalino SJY, Cui M, Kim JE, Kim HJ, Song DG, Nam SH, Kim S, Choi S, Lee JW. Cell Metab. 2019 Jun 4;29(6):1306-1319.e7. doi: 10.1016/j.cmet.2019.03.005. Epub 2019 Apr 4. PubMed |
| A Novel PSEN1 M139L Mutation Found in a Chinese Pedigree with Early-Onset Alzheimer's Disease Increases Abeta42/Abeta40 ratio. Qiu Q, Shen L, Jia L, Wang Q, Li F, Li Y, Jia J. J Alzheimers Dis. 2019;69(1):199-212. doi: 10.3233/JAD-181291. PubMed |
| Bromodomain inhibition of the coactivators CBP/EP300 facilitate cellular reprogramming. Ebrahimi A, Sevinc K, Gurhan Sevinc G, Cribbs AP, Philpott M, Uyulur F, Morova T, Dunford JE, Goklemez S, Ari S, Oppermann U, Onder TT. Nat Chem Biol. 2019 May;15(5):519-528. doi: 10.1038/s41589-019-0264-z. Epub 2019 Apr 8. PubMed |
A Synthetic Gene Circuit for Self-Regulating Delivery of Biologic Drugs in Engineered Tissues.
Pferdehirt L, Ross AK, Brunger JM, Guilak F.
Tissue Eng Part A. 2019 May;25(9-10):809-820. doi: 10.1089/ten.TEA.2019.0027.
PubMed
Associated Plasmids |
Essential Gene Profiles for Human Pluripotent Stem Cells Identify Uncharacterized Genes and Substrate Dependencies.
Mair B, Tomic J, Masud SN, Tonge P, Weiss A, Usaj M, Tong AHY, Kwan JJ, Brown KR, Titus E, Atkins M, Chan KSK, Munsie L, Habsid A, Han H, Kennedy M, Cohen B, Keller G, Moffat J.
Cell Rep. 2019 Apr 9;27(2):599-615.e12. doi: 10.1016/j.celrep.2019.02.041.
PubMed
Associated Plasmids |
| Thrombospondin Type 1 Domain-Containing 7A Localizes to the Slit Diaphragm and Stabilizes Membrane Dynamics of Fully Differentiated Podocytes. Herwig J, Skuza S, Sachs W, Sachs M, Failla AV, Rune G, Meyer TN, Fester L, Meyer-Schwesinger C. J Am Soc Nephrol. 2019 May;30(5):824-839. doi: 10.1681/ASN.2018090941. Epub 2019 Apr 10. PubMed |
| Lung cancer deficient in the tumor suppressor GATA4 is sensitive to TGFBR1 inhibition. Gao L, Hu Y, Tian Y, Fan Z, Wang K, Li H, Zhou Q, Zeng G, Hu X, Yu L, Zhou S, Tong X, Huang H, Chen H, Liu Q, Liu W, Zhang G, Zeng M, Zhou G, He Q, Ji H, Chen L. Nat Commun. 2019 Apr 10;10(1):1665. doi: 10.1038/s41467-019-09295-7. PubMed |
| Epigenetic and therapeutic implications of dnmt3b in temporomandibular joint osteoarthritis. Zhou Y, Chen M, O'Keefe RJ, Shen J, Li Z, Zhou J, Zhou X, Mao JJ. Am J Transl Res. 2019 Mar 15;11(3):1736-1747. eCollection 2019. PubMed |
| Crumbs3 is a critical factor that regulates invasion and metastasis of colon adenocarcinoma via the specific interaction with FGFR1. Iioka H, Saito K, Sakaguchi M, Tachibana T, Homma K, Kondo E. Int J Cancer. 2019 Apr 13. doi: 10.1002/ijc.32336. PubMed |
| CEA expression heterogeneity and plasticity confer resistance to the CEA-targeting bispecific immunotherapy antibody cibisatamab (CEA-TCB) in patient-derived colorectal cancer organoids. Gonzalez-Exposito R, Semiannikova M, Griffiths B, Khan K, Barber LJ, Woolston A, Spain G, von Loga K, Challoner B, Patel R, Ranes M, Swain A, Thomas J, Bryant A, Saffery C, Fotiadis N, Guettler S, Mansfield D, Melcher A, Powles T, Rao S, Watkins D, Chau I, Matthews N, Wallberg F, Starling N, Cunningham D, Gerlinger M. J Immunother Cancer. 2019 Apr 15;7(1):101. doi: 10.1186/s40425-019-0575-3. PubMed |
| Human Pluripotency Is Initiated and Preserved by a Unique Subset of Founder Cells. Nakanishi M, Mitchell RR, Benoit YD, Orlando L, Reid JC, Shimada K, Davidson KC, Shapovalova Z, Collins TJ, Nagy A, Bhatia M. Cell. 2019 May 2;177(4):910-924.e22. doi: 10.1016/j.cell.2019.03.013. Epub 2019 Apr 11. PubMed |
| HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries. Luo H, Sobh A, Vulpe CD, Brewer E, Dovat S, Qiu Y, Huang S. J Vis Exp. 2019 Mar 31;(145). doi: 10.3791/59382. PubMed |
| Establishment of an erythroid progenitor cell line capable of enucleation achieved with an inducible c-Myc vector. Mayers S, Moco PD, Maqbool T, Silva PN, Kilkenny DM, Audet J. BMC Biotechnol. 2019 Apr 15;19(1):21. doi: 10.1186/s12896-019-0515-9. PubMed |
| CCL5 promotes breast cancer recurrence through macrophage recruitment in residual tumors. Walens A, DiMarco AV, Lupo R, Kroger BR, Damrauer JS, Alvarez JV. Elife. 2019 Apr 16;8. pii: 43653. doi: 10.7554/eLife.43653. PubMed |
| Synthetic Lethality of Wnt Pathway Activation and Asparaginase in Drug-Resistant Acute Leukemias. Hinze L, Pfirrmann M, Karim S, Degar J, McGuckin C, Vinjamur D, Sacher J, Stevenson KE, Neuberg DS, Orellana E, Stanulla M, Gregory RI, Bauer DE, Wagner FF, Stegmaier K, Gutierrez A. Cancer Cell. 2019 Apr 15;35(4):664-676.e7. doi: 10.1016/j.ccell.2019.03.004. PubMed |
| The Influenza A Virus Endoribonuclease PA-X Usurps Host mRNA Processing Machinery to Limit Host Gene Expression. Gaucherand L, Porter BK, Levene RE, Price EL, Schmaling SK, Rycroft CH, Kevorkian Y, McCormick C, Khaperskyy DA, Gaglia MM. Cell Rep. 2019 Apr 16;27(3):776-792.e7. doi: 10.1016/j.celrep.2019.03.063. PubMed |
| KLF4 activates NFkappaB signaling and esophageal epithelial inflammation via the Rho-related GTP-binding protein RHOF. Shaverdashvili K, Padlo J, Weinblatt D, Jia Y, Jiang W, Rao D, Laczko D, Whelan KA, Lynch JP, Muir AB, Katz JP. PLoS One. 2019 Apr 18;14(4):e0215746. doi: 10.1371/journal.pone.0215746. eCollection 2019. PubMed |
| Cotargeting of BCL2 with Venetoclax and MCL1 with S63845 Is Synthetically Lethal In Vivo in Relapsed Mantle Cell Lymphoma. Prukova D, Andera L, Nahacka Z, Karolova J, Svaton M, Klanova M, Havranek O, Soukup J, Svobodova K, Zemanova Z, Tuskova D, Pokorna E, Helman K, Forsterova K, Pacheco-Blanco M, Vockova P, Berkova A, Fronkova E, Trneny M, Klener P. Clin Cancer Res. 2019 Jul 15;25(14):4455-4465. doi: 10.1158/1078-0432.CCR-18-3275. Epub 2019 Apr 19. PubMed |
| Systematic proteomics of endogenous human cohesin reveals an interaction with diverse splicing factors and RNA-binding proteins required for mitotic progression. Kim JS, He X, Liu J, Duan Z, Kim T, Gerard J, Kim B, Pillai MM, Lane WS, Noble WS, Budnik B, Waldman T. J Biol Chem. 2019 May 31;294(22):8760-8772. doi: 10.1074/jbc.RA119.007832. Epub 2019 Apr 22. PubMed |
| A novel retroviral vector system to analyze expression from mRNA with retained introns using fluorescent proteins and flow cytometry. Jackson PEH, Huang J, Sharma M, Rasmussen SK, Hammarskjold ML, Rekosh D. Sci Rep. 2019 Apr 23;9(1):6467. doi: 10.1038/s41598-019-42914-3. PubMed |
| Insulin Induces Microtubule Stabilization and Regulates the Microtubule Plus-end Tracking Protein Network in Adipocytes. Parker SS, Krantz J, Kwak EA, Barker NK, Deer CG, Lee NY, Mouneimne G, Langlais PR. Mol Cell Proteomics. 2019 Jul;18(7):1363-1381. doi: 10.1074/mcp.RA119.001450. Epub 2019 Apr 24. PubMed |
| JUND regulates pancreatic beta cell survival during metabolic stress. Good AL, Cannon CE, Haemmerle MW, Yang J, Stanescu DE, Doliba NM, Birnbaum MJ, Stoffers DA. Mol Metab. 2019 Jul;25:95-106. doi: 10.1016/j.molmet.2019.04.007. Epub 2019 Apr 11. PubMed |
| Chemical suppression of specific C-C chemokine signaling pathways enhances cardiac reprogramming. Guo Y, Lei I, Tian S, Gao W, Hacer K, Li Y, Wang S, Liu L, Wang Z. J Biol Chem. 2019 Jun 7;294(23):9134-9146. doi: 10.1074/jbc.RA118.006000. Epub 2019 Apr 25. PubMed |
| Optogenetic Monitoring of the Glutathione Redox State in Engineered Human Myocardium. Trautsch I, Heta E, Soong PL, Levent E, Nikolaev VO, Bogeski I, Katschinski DM, Mayr M, Zimmermann WH. Front Physiol. 2019 Apr 4;10:272. doi: 10.3389/fphys.2019.00272. eCollection 2019. PubMed |
| CRISPR Activation Enhances In Vitro Potency of AAV Vectors Driven by Tissue-Specific Promoters. McDougald DS, Duong TT, Palozola KC, Marsh A, Papp TE, Mills JA, Zhou S, Bennett J. Mol Ther Methods Clin Dev. 2019 Mar 28;13:380-389. doi: 10.1016/j.omtm.2019.03.004. eCollection 2019 Jun 14. PubMed |
| CRISPR/Cas9-generated mouse model of Duchenne muscular dystrophy recapitulating a newly identified large 430 kb deletion in the human DMD gene. Egorova TV, Zotova ED, Reshetov DA, Polikarpova AV, Vassilieva SG, Vlodavets DV, Gavrilov AA, Ulianov SV, Buchman VL, Deykin AV. Dis Model Mech. 2019 Apr 25;12(4). pii: 12/4/dmm037655. doi: 10.1242/dmm.037655. PubMed |
| FKBP12 mediates necroptosis by initiating RIPK1-RIPK3-MLKL signal transduction in response to TNF receptor 1 ligation. Wang Z, Feng J, Yu J, Chen G. J Cell Sci. 2019 May 20;132(10). pii: jcs.227777. doi: 10.1242/jcs.227777. PubMed |
| GemC1 governs multiciliogenesis through direct interaction with and transcriptional regulation of p73. Lalioti ME, Arbi M, Loukas I, Kaplani K, Kalogeropoulou A, Lokka G, Kyrousi C, Mizi A, Georgomanolis T, Josipovic N, Gkikas D, Benes V, Politis PK, Papantonis A, Lygerou Z, Taraviras S. J Cell Sci. 2019 Jun 3;132(11). pii: jcs.228684. doi: 10.1242/jcs.228684. PubMed |
| CRISPR Screening in Single Cells. Henriksson J. Methods Mol Biol. 2019;1979:395-406. doi: 10.1007/978-1-4939-9240-9_23. PubMed |
| Human Intestinal Enteroids With Inducible Neurogenin-3 Expression as a Novel Model of Gut Hormone Secretion. Chang-Graham AL, Danhof HA, Engevik MA, Tomaro-Duchesneau C, Karandikar UC, Estes MK, Versalovic J, Britton RA, Hyser JM. Cell Mol Gastroenterol Hepatol. 2019 Apr 25;8(2):209-229. doi: 10.1016/j.jcmgh.2019.04.010. PubMed |
Hypoxia Rescues Frataxin Loss by Restoring Iron Sulfur Cluster Biogenesis.
Ast T, Meisel JD, Patra S, Wang H, Grange RMH, Kim SH, Calvo SE, Orefice LL, Nagashima F, Ichinose F, Zapol WM, Ruvkun G, Barondeau DP, Mootha VK.
Cell. 2019 May 30;177(6):1507-1521.e16. doi: 10.1016/j.cell.2019.03.045. Epub 2019 Apr 25.
PubMed
Associated Plasmids |
| Visualizing Engrafted Human Cancer and Therapy Responses in Immunodeficient Zebrafish. Yan C, Brunson DC, Tang Q, Do D, Iftimia NA, Moore JC, Hayes MN, Welker AM, Garcia EG, Dubash TD, Hong X, Drapkin BJ, Myers DT, Phat S, Volorio A, Marvin DL, Ligorio M, Dershowitz L, McCarthy KM, Karabacak MN, Fletcher JA, Sgroi DC, Iafrate JA, Maheswaran S, Dyson NJ, Haber DA, Rawls JF, Langenau DM. Cell. 2019 Jun 13;177(7):1903-1914.e14. doi: 10.1016/j.cell.2019.04.004. Epub 2019 Apr 25. PubMed |
| METTL1 Promotes let-7 MicroRNA Processing via m7G Methylation. Pandolfini L, Barbieri I, Bannister AJ, Hendrick A, Andrews B, Webster N, Murat P, Mach P, Brandi R, Robson SC, Migliori V, Alendar A, d'Onofrio M, Balasubramanian S, Kouzarides T. Mol Cell. 2019 Jun 20;74(6):1278-1290.e9. doi: 10.1016/j.molcel.2019.03.040. Epub 2019 Apr 25. PubMed |
| Canonical PRC1 controls sequence-independent propagation of Polycomb-mediated gene silencing. Moussa HF, Bsteh D, Yelagandula R, Pribitzer C, Stecher K, Bartalska K, Michetti L, Wang J, Zepeda-Martinez JA, Elling U, Stuckey JI, James LI, Frye SV, Bell O. Nat Commun. 2019 Apr 29;10(1):1931. doi: 10.1038/s41467-019-09628-6. PubMed |
| Influence of SHH/GLI1 axis on EMT mediated migration and invasion of breast cancer cells. Riaz SK, Ke Y, Wang F, Kayani MA, Malik MFA. Sci Rep. 2019 Apr 29;9(1):6620. doi: 10.1038/s41598-019-43093-x. PubMed |
| MRPS25 mutations impair mitochondrial translation and cause encephalomyopathy. Bugiardini E, Mitchell AL, Rosa ID, Horning-Do HT, Pitmann A, Poole OV, Holton JL, Shah S, Woodward C, Hargreaves I, Quinlivan R, Amunts A, Wiesner RJ, Houlden H, Holt IJ, Hanna MG, Pitceathly RDS, Spinazzola A. Hum Mol Genet. 2019 Apr 30. pii: 5482278. doi: 10.1093/hmg/ddz093. PubMed |
| Lysosomal proteome analysis reveals that CLN3-defective cells have multiple enzyme deficiencies associated with changes in intracellular trafficking. Schmidtke C, Tiede S, Thelen M, Kakela R, Jabs S, Makrypidi G, Sylvester M, Schweizer M, Braren I, Brocke-Ahmadinejad N, Cotman SL, Schulz A, Gieselmann V, Braulke T. J Biol Chem. 2019 Jun 14;294(24):9592-9604. doi: 10.1074/jbc.RA119.008852. Epub 2019 Apr 30. PubMed |
| CD13 tethers the IQGAP1-ARF6-EFA6 complex to the plasma membrane to promote ARF6 activation, beta1 integrin recycling, and cell migration. Ghosh M, Lo R, Ivic I, Aguilera B, Qendro V, Devarakonda C, Shapiro LH. Sci Signal. 2019 Apr 30;12(579). pii: 12/579/eaav5938. doi: 10.1126/scisignal.aav5938. PubMed |
| Molecular dissection of box jellyfish venom cytotoxicity highlights an effective venom antidote. Lau MT, Manion J, Littleboy JB, Oyston L, Khuong TM, Wang QP, Nguyen DT, Hesselson D, Seymour JE, Neely GG. Nat Commun. 2019 Apr 30;10(1):1655. doi: 10.1038/s41467-019-09681-1. PubMed |
| Inhibition of MYC by the SMARCB1 tumor suppressor. Weissmiller AM, Wang J, Lorey SL, Howard GC, Martinez E, Liu Q, Tansey WP. Nat Commun. 2019 May 1;10(1):2014. doi: 10.1038/s41467-019-10022-5. PubMed |
| Design and construction of a recombinant lentiviral vector with specific tropism to human epidermal growth factor-overexpressed cancer cells: Developing a new retargeting system for lentivirus vectors. Ebrahimabadi S, Shahbazi M, Akbari M, Golalipour M, Farazmandfar T. J Gene Med. 2019 Jun;21(6):e3095. doi: 10.1002/jgm.3095. Epub 2019 May 20. PubMed |
| Mitochondrial ClpP-Mediated Proteolysis Induces Selective Cancer Cell Lethality. Ishizawa J, Zarabi SF, Davis RE, Halgas O, Nii T, Jitkova Y, Zhao R, St-Germain J, Heese LE, Egan G, Ruvolo VR, Barghout SH, Nishida Y, Hurren R, Ma W, Gronda M, Link T, Wong K, Mabanglo M, Kojima K, Borthakur G, MacLean N, Ma MCJ, Leber AB, Minden MD, Houry W, Kantarjian H, Stogniew M, Raught B, Pai EF, Schimmer AD, Andreeff M. Cancer Cell. 2019 May 13;35(5):721-737.e9. doi: 10.1016/j.ccell.2019.03.014. Epub 2019 May 2. PubMed |
| Chemoproteomic Profiling Uncovers CDK4-Mediated Phosphorylation of the Translational Suppressor 4E-BP1. Mitchell DC, Menon A, Garner AL. Cell Chem Biol. 2019 Jul 18;26(7):980-990.e8. doi: 10.1016/j.chembiol.2019.03.012. Epub 2019 May 2. PubMed |
| Genome-Wide CRISPR Screening Identifies the Tumor Suppressor Candidate OVCA2 As a Determinant of Tolerance to Acetaldehyde. Sobh A, Loguinov A, Stornetta A, Balbo S, Tagmount A, Zhang L, Vulpe CD. Toxicol Sci. 2019 May 1;169(1):235-245. doi: 10.1093/toxsci/kfz037. PubMed |
| BIRC5 is a target for molecular imaging and detection of human pancreatic cancer. Liu SH, Hong Y, Markowiak S, Sanchez R, Creeden J, Nemunaitis J, Kalinoski A, Willey J, Erhardt P, Lee J, van Dam M, Brunicardi FC. Cancer Lett. 2019 Aug 10;457:10-19. doi: 10.1016/j.canlet.2019.04.036. Epub 2019 May 3. PubMed |
| Deficiency of stress-associated gene Nupr1 increases bone volume by attenuating differentiation of osteoclasts and enhancing differentiation of osteoblasts. Shiraki M, Xu X, Iovanna JL, Kukita T, Hirata H, Kamohara A, Kubota Y, Miyamoto H, Mawatari M, Kukita A. FASEB J. 2019 Aug;33(8):8836-8852. doi: 10.1096/fj.201802322RR. Epub 2019 May 8. PubMed |
| The ER Membrane Protein Complex Promotes Biogenesis of Dengue and Zika Virus Non-structural Multi-pass Transmembrane Proteins to Support Infection. Lin DL, Inoue T, Chen YJ, Chang A, Tsai B, Tai AW. Cell Rep. 2019 May 7;27(6):1666-1674.e4. doi: 10.1016/j.celrep.2019.04.051. PubMed |
| Chromatin Decondensation by FOXP2 Promotes Human Neuron Maturation and Expression of Neurodevelopmental Disease Genes. Hickey SL, Berto S, Konopka G. Cell Rep. 2019 May 7;27(6):1699-1711.e9. doi: 10.1016/j.celrep.2019.04.044. PubMed |
| Effects of histone deacetylase inhibitor Scriptaid and parathyroid hormone on osteocyte functions and metabolism. Sun N, Uda Y, Azab E, Kochen A, Santos RNCE, Shi C, Kobayashi T, Wein MN, Divieti Pajevic P. J Biol Chem. 2019 Jun 21;294(25):9722-9733. doi: 10.1074/jbc.RA118.007312. Epub 2019 May 8. PubMed |
| SpCas9-expression by tumor cells can cause T cell-dependent tumor rejection in immunocompetent mice. Ajina R, Zamalin D, Zuo A, Moussa M, Catalfamo M, Jablonski SA, Weiner LM. Oncoimmunology. 2019 Mar 16;8(5):e1577127. doi: 10.1080/2162402X.2019.1577127. eCollection 2019. PubMed |
| HDAC1,2 Knock-Out and HDACi Induced Cell Apoptosis in Imatinib-Resistant K562 Cells. Chen SH, Chow JM, Hsieh YY, Lin CY, Hsu KW, Hsieh WS, Chi WM, Shabangu BM, Lee CH. Int J Mol Sci. 2019 May 8;20(9). pii: ijms20092271. doi: 10.3390/ijms20092271. PubMed |
| Sox17 is required for endothelial regeneration following inflammation-induced vascular injury. Liu M, Zhang L, Marsboom G, Jambusaria A, Xiong S, Toth PT, Benevolenskaya EV, Rehman J, Malik AB. Nat Commun. 2019 May 9;10(1):2126. doi: 10.1038/s41467-019-10134-y. PubMed |
| Identification of Cancer Drivers at CTCF Insulators in 1,962 Whole Genomes. Liu EM, Martinez-Fundichely A, Diaz BJ, Aronson B, Cuykendall T, MacKay M, Dhingra P, Wong EWP, Chi P, Apostolou E, Sanjana NE, Khurana E. Cell Syst. 2019 May 22;8(5):446-455.e8. doi: 10.1016/j.cels.2019.04.001. Epub 2019 May 8. PubMed |
| Targeted therapy based on p53 reactivation reduces both glioblastoma cell growth and resistance to temozolomide. Forte IM, Indovina P, Iannuzzi CA, Cirillo D, Di Marzo D, Barone D, Capone F, Pentimalli F, Giordano A. Int J Oncol. 2019 Jun;54(6):2189-2199. doi: 10.3892/ijo.2019.4788. Epub 2019 Apr 16. PubMed |
| The long noncoding RNA TP73-AS1 promotes tumorigenicity of medulloblastoma cells. Varon M, Levy T, Mazor G, Ben David H, Marciano R, Krelin Y, Prasad M, Elkabets M, Pauck D, Ahmadov U, Picard D, Qin N, Borkhardt A, Reifenberger G, Leprivier G, Remke M, Rotblat B. Int J Cancer. 2019 May 13. doi: 10.1002/ijc.32400. PubMed |
| A 3D culture model of innervated human skeletal muscle enables studies of the adult neuromuscular junction. Afshar Bakooshli M, Lippmann ES, Mulcahy B, Iyer N, Nguyen CT, Tung K, Stewart BA, van den Dorpel H, Fuehrmann T, Shoichet M, Bigot A, Pegoraro E, Ahn H, Ginsberg H, Zhen M, Ashton RS, Gilbert PM. Elife. 2019 May 14;8. pii: 44530. doi: 10.7554/eLife.44530. PubMed |
| BCL2 Amplicon Loss and Transcriptional Remodeling Drives ABT-199 Resistance in B Cell Lymphoma Models. Zhao X, Ren Y, Lawlor M, Shah BD, Park PMC, Lwin T, Wang X, Liu K, Wang M, Gao J, Li T, Xu M, Silva AS, Lee K, Zhang T, Koomen JM, Jiang H, Sudalagunta PR, Meads MB, Cheng F, Bi C, Fu K, Fan H, Dalton WS, Moscinski LC, Shain KH, Sotomayor EM, Wang GG, Gray NS, Cleveland JL, Qi J, Tao J. Cancer Cell. 2019 May 13;35(5):752-766.e9. doi: 10.1016/j.ccell.2019.04.005. PubMed |
| MEIS1 knockdown may promote differentiation of esophageal squamous carcinoma cell line KYSE-30. Mahmoudian RA, Bahadori B, Rad A, Abbaszadegan MR, Forghanifard MM. Mol Genet Genomic Med. 2019 Jul;7(7):e00746. doi: 10.1002/mgg3.746. Epub 2019 May 14. PubMed |
| MEK inhibitors activate Wnt signalling and induce stem cell plasticity in colorectal cancer. Zhan T, Ambrosi G, Wandmacher AM, Rauscher B, Betge J, Rindtorff N, Haussler RS, Hinsenkamp I, Bamberg L, Hessling B, Muller-Decker K, Erdmann G, Burgermeister E, Ebert MP, Boutros M. Nat Commun. 2019 May 16;10(1):2197. doi: 10.1038/s41467-019-09898-0. PubMed |
Targeted and Persistent 8-Oxoguanine Base Damage at Telomeres Promotes Telomere Loss and Crisis.
Fouquerel E, Barnes RP, Uttam S, Watkins SC, Bruchez MP, Opresko PL.
Mol Cell. 2019 Jul 11;75(1):117-130.e6. doi: 10.1016/j.molcel.2019.04.024. Epub 2019 May 14.
PubMed
Associated Plasmids |
| Longitudinal Analysis of the Human B Cell Response to Ebola Virus Infection. Davis CW, Jackson KJL, McElroy AK, Halfmann P, Huang J, Chennareddy C, Piper AE, Leung Y, Albarino CG, Crozier I, Ellebedy AH, Sidney J, Sette A, Yu T, Nielsen SCA, Goff AJ, Spiropoulou CF, Saphire EO, Cavet G, Kawaoka Y, Mehta AK, Glass PJ, Boyd SD, Ahmed R. Cell. 2019 May 30;177(6):1566-1582.e17. doi: 10.1016/j.cell.2019.04.036. Epub 2019 May 16. PubMed |
| PES1 is a critical component of telomerase assembly and regulates cellular senescence. Cheng L, Yuan B, Ying S, Niu C, Mai H, Guan X, Yang X, Teng Y, Lin J, Huang J, Jin R, Wu J, Liu B, Chang S, Wang E, Zhang C, Hou N, Cheng X, Xu D, Yang X, Gao S, Ye Q. Sci Adv. 2019 May 15;5(5):eaav1090. doi: 10.1126/sciadv.aav1090. eCollection 2019 May. PubMed |
| TNF-alpha/IL-1beta-licensed mesenchymal stromal cells promote corneal allograft survival via myeloid cell-mediated induction of Foxp3(+) regulatory T cells in the lung. Murphy N, Treacy O, Lynch K, Morcos M, Lohan P, Howard L, Fahy G, Griffin MD, Ryan AE, Ritter T. FASEB J. 2019 Aug;33(8):9404-9421. doi: 10.1096/fj.201900047R. Epub 2019 May 20. PubMed |
| Aberrant methylation status of SPG20 promoter in hepatocellular carcinoma: A potential tumor metastasis biomarker. He L, Fan X, Li Y, Cui B, Shi Z, Zhou D, Lin H. Cancer Genet. 2019 Apr;233-234:48-55. doi: 10.1016/j.cancergen.2019.04.003. Epub 2019 Apr 12. PubMed |
| Parenchymal and stromal tissue regeneration of tooth organ by pivotal signals reinstated in decellularized matrix. He L, Zhou J, Chen M, Lin CS, Kim SG, Zhou Y, Xiang L, Xie M, Bai H, Yao H, Shi C, Coelho PG, Bromage TG, Hu B, Tovar N, Witek L, Wu J, Chen K, Gu W, Zheng J, Sheu TJ, Zhong J, Wen J, Niu Y, Cheng B, Gong Q, Owens DM, Stanislauskas M, Pei J, Chotkowski G, Wang S, Yang G, Zegarelli DJ, Shi X, Finkel M, Zhang W, Li J, Cheng J, Tarnow DP, Zhou X, Wang Z, Jiang X, Romanov A, Rowe DW, Wang S, Ye L, Ling J, Mao J. Nat Mater. 2019 Jun;18(6):627-637. doi: 10.1038/s41563-019-0368-6. Epub 2019 May 21. PubMed |
| TRAIL-R1 and TRAIL-R2 Mediate TRAIL-Dependent Apoptosis in Activated Primary Human B Lymphocytes. Staniek J, Lorenzetti R, Heller B, Janowska I, Schneider P, Unger S, Warnatz K, Seidl M, Venhoff N, Thiel J, Smulski CR, Rizzi M. Front Immunol. 2019 Apr 30;10:951. doi: 10.3389/fimmu.2019.00951. eCollection 2019. PubMed |
| Mitohormesis Primes Tumor Invasion and Metastasis. Kenny TC, Craig AJ, Villanueva A, Germain D. Cell Rep. 2019 May 21;27(8):2292-2303.e6. doi: 10.1016/j.celrep.2019.04.095. PubMed |
| Detection and Quantification of Label-Free Infectious Adenovirus Using a Switch-On Cell-Based Fluorescent Biosensor. Guerreiro MR, Freitas DF, Alves PM, Coroadinha AS. ACS Sens. 2019 Jun 28;4(6):1654-1661. doi: 10.1021/acssensors.9b00489. Epub 2019 Jun 5. PubMed |
| A conserved PLPLRT/SD motif of STING mediates the recruitment and activation of TBK1. Zhao B, Du F, Xu P, Shu C, Sankaran B, Bell SL, Liu M, Lei Y, Gao X, Fu X, Zhu F, Liu Y, Laganowsky A, Zheng X, Ji JY, West AP, Watson RO, Li P. Nature. 2019 May;569(7758):718-722. doi: 10.1038/s41586-019-1228-x. Epub 2019 May 22. PubMed |
| Genetic Modification of Human Primary Keratinocytes by Lentiviral Vectors. Freije A, Sanz-Gomez N, Gandarillas A. Methods Mol Biol. 2019 May 24. doi: 10.1007/7651_2019_238. PubMed |
| Deciphering host lysosome-mediated elimination of Plasmodium berghei liver stage parasites. Niklaus L, Agop-Nersesian C, Schmuckli-Maurer J, Wacker R, Grunig V, Heussler VT. Sci Rep. 2019 May 28;9(1):7967. doi: 10.1038/s41598-019-44449-z. PubMed |
| Lentiviral CRISPR Epigenome Editing of Inflammatory Receptors as a Gene Therapy Strategy for Disc Degeneration. Farhang N, Ginley-Hidinger M, Berrett KC, Gertz J, Lawrence B, Bowles RD. Hum Gene Ther. 2019 Jul 17. doi: 10.1089/hum.2019.005. PubMed |
| A Yeast Suppressor Screen Used To Identify Mammalian SIRT1 as a Proviral Factor for Middle East Respiratory Syndrome Coronavirus Replication. Weston S, Matthews KL, Lent R, Vlk A, Haupt R, Kingsbury T, Frieman MB. J Virol. 2019 Jul 30;93(16). pii: JVI.00197-19. doi: 10.1128/JVI.00197-19. Print 2019 Aug 15. PubMed |
| Two human patient mitochondrial pyruvate carrier mutations reveal distinct molecular mechanisms of dysfunction. Oonthonpan L, Rauckhorst AJ, Gray LR, Boutron AC, Taylor EB. JCI Insight. 2019 May 30;5. pii: 126132. doi: 10.1172/jci.insight.126132. PubMed |
| LIM and SH3 protein 1 induces glioma growth and invasion through PI3K/AKT signaling and epithelial-mesenchymal transition. Zhong C, Li X, Tao B, Peng L, Peng T, Yang X, Xia X, Chen L. Biomed Pharmacother. 2019 Aug;116:109013. doi: 10.1016/j.biopha.2019.109013. Epub 2019 May 27. PubMed |
| Generation of an immortalized erythroid progenitor cell line from peripheral blood: A model system for the functional analysis of Plasmodium spp. invasion. Scully EJ, Shabani E, Rangel GW, Gruring C, Kanjee U, Clark MA, Chaand M, Kurita R, Nakamura Y, Ferreira MU, Duraisingh MT. Am J Hematol. 2019 May 31. doi: 10.1002/ajh.25543. PubMed |
| Preferential expression of sialyl 6'-sulfo N-acetyllactosamine-capped O-glycans on high endothelial venules in human peripheral lymph nodes. Tsutsumiuchi M, Hoshino H, Kogami A, Tsutsumiuchi T, Yokoyama O, Akama TO, Kobayashi M. Lab Invest. 2019 May 31. pii: 10.1038/s41374-019-0267-0. doi: 10.1038/s41374-019-0267-0. PubMed |
| Thermoregulation via Temperature-Dependent PGD2 Production in Mouse Preoptic Area. Wang TA, Teo CF, Akerblom M, Chen C, Tynan-La Fontaine M, Greiner VJ, Diaz A, McManus MT, Jan YN, Jan LY. Neuron. 2019 Jul 17;103(2):309-322.e7. doi: 10.1016/j.neuron.2019.04.035. Epub 2019 May 28. PubMed |
| A PRDM16-Driven Metabolic Signal from Adipocytes Regulates Precursor Cell Fate. Wang W, Ishibashi J, Trefely S, Shao M, Cowan AJ, Sakers A, Lim HW, O'Connor S, Doan MT, Cohen P, Baur JA, King MT, Veech RL, Won KJ, Rabinowitz JD, Snyder NW, Gupta RK, Seale P. Cell Metab. 2019 Jul 2;30(1):174-189.e5. doi: 10.1016/j.cmet.2019.05.005. Epub 2019 May 30. PubMed |
| Development of an improved lentiviral based vector system for the stable expression of monoclonal antibody in CHO cells. Mohammadian O, Rajabibazl M, Pourmaleki E, Bayat H, Ahani R, Rahimpour A. Prep Biochem Biotechnol. 2019;49(8):822-829. doi: 10.1080/10826068.2019.1621893. Epub 2019 Jun 1. PubMed |
| EMSY expression affects multiple components of the skin barrier with relevance to atopic dermatitis. Elias MS, Wright SC, Remenyi J, Abbott JC, Bray SE, Cole C, Edwards S, Gierlinski M, Glok M, McGrath JA, Nicholson WV, Paternoster L, Prescott AR, Have ST, Whitfield PD, Lamond AI, Brown SJ. J Allergy Clin Immunol. 2019 May 31. pii: S0091-6749(19)30741-9. doi: 10.1016/j.jaci.2019.05.024. PubMed |
| Discovery of a Pathogenic Variant rs139379666 (p. P2974L) in ATM for Breast Cancer Risk in Chinese Populations. Guo X, Lin W, Bai M, Li H, Wen W, Zeng C, Chen Z, He J, Chen J, Cai Q, Long J, Jia WH, Shu XO, Zheng W. Cancer Epidemiol Biomarkers Prev. 2019 Aug;28(8):1308-1315. doi: 10.1158/1055-9965.EPI-18-1294. Epub 2019 Jun 3. PubMed |
| Human evolved regulatory elements modulate genes involved in cortical expansion and neurodevelopmental disease susceptibility. Won H, Huang J, Opland CK, Hartl CL, Geschwind DH. Nat Commun. 2019 Jun 3;10(1):2396. doi: 10.1038/s41467-019-10248-3. PubMed |
| Opposing effects of acute versus chronic inhibition of p53 on decitabine's efficacy in myeloid neoplasms. Tamura M, Yonezawa T, Liu X, Asada S, Hayashi Y, Fukuyama T, Tanaka Y, Kitamura T, Goyama S. Sci Rep. 2019 Jun 3;9(1):8171. doi: 10.1038/s41598-019-44496-6. PubMed |
| The length of guide RNA and target DNA heteroduplex effects on CRISPR/Cas9 mediated genome editing efficiency in porcine cells. Lv J, Wu S, Wei R, Li Y, Jin J, Mu Y, Zhang Y, Kong Q, Weng X, Liu Z. J Vet Sci. 2019 May;20(3):e23. doi: 10.4142/jvs.2019.20.e23. PubMed |
| The Effect of FERMT1 Regulated by miR-24 on the Growth and Radiation Resistance of Esophageal Cancer. Yan Q, Chen T, Yang H, Yu H, Zheng Y, He T, Wang J. J Biomed Nanotechnol. 2019 Mar 1;15(3):621-631. doi: 10.1166/jbn.2019.2711. PubMed |
| Overexpression of zinc finger protein 384 (ZNF 384), a poor prognostic predictor, promotes cell growth by upregulating the expression of Cyclin D1 in Hepatocellular carcinoma. He L, Fan X, Li Y, Chen M, Cui B, Chen G, Dai Y, Zhou D, Hu X, Lin H. Cell Death Dis. 2019 Jun 5;10(6):444. doi: 10.1038/s41419-019-1681-3. PubMed |
| An NLRP3 inflammasome-triggered cytokine storm contributes to Streptococcal toxic shock-like syndrome (STSLS). Lin L, Xu L, Lv W, Han L, Xiang Y, Fu L, Jin M, Zhou R, Chen H, Zhang A. PLoS Pathog. 2019 Jun 6;15(6):e1007795. doi: 10.1371/journal.ppat.1007795. eCollection 2019 Jun. PubMed |
| Chemical screen for epigenetic barriers to single allele activation of Oct4. Headley KM, Kedziora KM, Alejo A, Lai EZ, Purvis JE, Hathaway NA. Stem Cell Res. 2019 Jul;38:101470. doi: 10.1016/j.scr.2019.101470. Epub 2019 May 24. PubMed |
| Clustered telomeres in phase-separated nuclear condensates engage mitotic DNA synthesis through BLM and RAD52. Min J, Wright WE, Shay JW. Genes Dev. 2019 Jul 1;33(13-14):814-827. doi: 10.1101/gad.324905.119. Epub 2019 Jun 6. PubMed |
| A novel YAP1/SLC35B4 regulatory axis contributes to proliferation and progression of gastric carcinoma. Liu J, Zhao X, Wang K, Zhang X, Yu Y, Lv Y, Zhang S, Zhang L, Guo Y, Li Y, Yang A, Zhang R, Li J. Cell Death Dis. 2019 Jun 7;10(6):452. doi: 10.1038/s41419-019-1674-2. PubMed |
| Metabolic stress activates an ERK/hnRNPK/DDX3X pathway in pancreatic beta cells. Good AL, Haemmerle MW, Oguh AU, Doliba NM, Stoffers DA. Mol Metab. 2019 Aug;26:45-56. doi: 10.1016/j.molmet.2019.05.009. Epub 2019 May 24. PubMed |
| Symbiotic Macrophage-Glioma Cell Interactions Reveal Synthetic Lethality in PTEN-Null Glioma. Chen P, Zhao D, Li J, Liang X, Li J, Chang A, Henry VK, Lan Z, Spring DJ, Rao G, Wang YA, DePinho RA. Cancer Cell. 2019 Jun 10;35(6):868-884.e6. doi: 10.1016/j.ccell.2019.05.003. PubMed |
| KMT5A promotes metastasis of clear cell renal cell carcinoma through reducing cadherin-1 expression. Lin ZZ, Ming DS, Chen YB, Zhang JM, Chen HH, Jiang JJ, Zhang ZS. Oncol Lett. 2019 Jun;17(6):4907-4913. doi: 10.3892/ol.2019.10163. Epub 2019 Mar 19. PubMed |
| Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome. Sharif H, Wang L, Wang WL, Magupalli VG, Andreeva L, Qiao Q, Hauenstein AV, Wu Z, Nunez G, Mao Y, Wu H. Nature. 2019 Jun;570(7761):338-343. doi: 10.1038/s41586-019-1295-z. Epub 2019 Jun 12. PubMed |
| Berberine promotes the recruitment and activation of brown adipose tissue in mice and humans. Wu L, Xia M, Duan Y, Zhang L, Jiang H, Hu X, Yan H, Zhang Y, Gu Y, Shi H, Li J, Gao X, Li J. Cell Death Dis. 2019 Jun 13;10(6):468. doi: 10.1038/s41419-019-1706-y. PubMed |
| Mitochondrial pyruvate import is a metabolic vulnerability in androgen receptor-driven prostate cancer. Bader DA, Hartig SM, Putluri V, Foley C, Hamilton MP, Smith EA, Saha PK, Panigrahi A, Walker C, Zong L, Martini-Stoica H, Chen R, Rajapakshe K, Coarfa C, Sreekumar A, Mitsiades N, Bankson JA, Ittmann MM, O'Malley BW, Putluri N, McGuire SE. Nat Metab. 2019 Jan;1(1):70-85. doi: 10.1038/s42255-018-0002-y. Epub 2018 Nov 19. PubMed |
| Self-assembled nanofibrils from RGD-functionalized cellulose nanocrystals to improve the performance of PEI/DNA polyplexes. Hujaya SD, Manninen A, Kling K, Wagner JB, Vainio SJ, Liimatainen H. J Colloid Interface Sci. 2019 Jun 3;553:71-82. doi: 10.1016/j.jcis.2019.06.001. PubMed |
| MHC-I peptide binding activity assessed by exchange after cleavage of peptide covalently linked to beta2-microglobulin. Jurewicz MM, Willis RA, Altman JD, Stern LJ. Anal Biochem. 2019 Jun 12. pii: S0003-2697(19)30180-0. doi: 10.1016/j.ab.2019.05.017. PubMed |
| Somatic loss of PIK3R1 may sensitize breast cancer to inhibitors of the MAPK pathway. Turturro SB, Najor MS, Yung T, Portt L, Malarkey CS, Abukhdeir AM, Cobleigh MA. Breast Cancer Res Treat. 2019 Sep;177(2):325-333. doi: 10.1007/s10549-019-05320-x. Epub 2019 Jun 17. PubMed |
| Abundance of d-2-hydroxyglutarate in G2/M is determined by FOXM1 in mutant IDH1-expressing cells. Bala Bhaskara Rao K, Katragunta K, Sarma UM, Jain N. FEBS Lett. 2019 Jun 18. doi: 10.1002/1873-3468.13500. PubMed |
| p73 regulates epidermal wound healing and induced keratinocyte programming. Beeler JS, Marshall CB, Gonzalez-Ericsson PI, Shaver TM, Santos Guasch GL, Lea ST, Johnson KN, Jin H, Venters BJ, Sanders ME, Pietenpol JA. PLoS One. 2019 Jun 19;14(6):e0218458. doi: 10.1371/journal.pone.0218458. eCollection 2019. PubMed |
| The Myb-MuvB Complex Is Required for YAP-Dependent Transcription of Mitotic Genes. Pattschull G, Walz S, Grundl M, Schwab M, Ruhl E, Baluapuri A, Cindric-Vranesic A, Kneitz S, Wolf E, Ade CP, Rosenwald A, von Eyss B, Gaubatz S. Cell Rep. 2019 Jun 18;27(12):3533-3546.e7. doi: 10.1016/j.celrep.2019.05.071. PubMed |
| Inhibition of ERRalpha Prevents Mitochondrial Pyruvate Uptake Exposing NADPH-Generating Pathways as Targetable Vulnerabilities in Breast Cancer. Park S, Safi R, Liu X, Baldi R, Liu W, Liu J, Locasale JW, Chang CY, McDonnell DP. Cell Rep. 2019 Jun 18;27(12):3587-3601.e4. doi: 10.1016/j.celrep.2019.05.066. PubMed |
| Enhancement of LIN28B-induced hematopoietic reprogramming by IGF2BP3. Wang S, Chim B, Su Y, Khil P, Wong M, Wang X, Foroushani A, Smith PT, Liu X, Li R, Ganesan S, Kanellopoulou C, Hafner M, Muljo SA. Genes Dev. 2019 Aug 1;33(15-16):1048-1068. doi: 10.1101/gad.325100.119. Epub 2019 Jun 20. PubMed |
| Retinol binding protein 4 mediates MEHP-induced glucometabolic abnormalities in HepG2 cells. Wang F, Chang C, Li R, Zhang Z, Jiang H, Zeng N, Li D, Chen L, Xiao Y, Chen W, Wang Q. Toxicology. 2019 Aug 1;424:152236. doi: 10.1016/j.tox.2019.06.007. Epub 2019 Jun 20. PubMed |
| DEPTOR induces a partial epithelial-to-mesenchymal transition and metastasis via autocrine TGFbeta1 signaling and is associated with poor prognosis in hepatocellular carcinoma. Chen J, Zhu H, Liu Q, Ning D, Zhang Z, Zhang L, Mo J, Du P, Liu X, Song S, Fan Y, Liang H, Liu J, Zhang B, Chen X. J Exp Clin Cancer Res. 2019 Jun 22;38(1):273. doi: 10.1186/s13046-019-1220-1. PubMed |
| An Oxygen-Dependent Interaction between FBXL5 and the CIA-Targeting Complex Regulates Iron Homeostasis. Mayank AK, Pandey V, Vashisht AA, Barshop WD, Rayatpisheh S, Sharma T, Haque T, Powers DN, Wohlschlegel JA. Mol Cell. 2019 Jul 25;75(2):382-393.e5. doi: 10.1016/j.molcel.2019.05.020. Epub 2019 Jun 19. PubMed |
| Zika virus NS5 protein inhibits cell growth and invasion of glioma. Li H, Hu Y, Huang J, Feng Y, Zhang Z, Zhong K, Chen Y, Wang Z, Huang C, Yang H, Tong A. Biochem Biophys Res Commun. 2019 Aug 20;516(2):515-520. doi: 10.1016/j.bbrc.2019.06.064. Epub 2019 Jun 20. PubMed |
Single-Cell Transcriptomic Analyses of Cell Fate Transitions during Human Cardiac Reprogramming.
Zhou Y, Liu Z, Welch JD, Gao X, Wang L, Garbutt T, Keepers B, Ma H, Prins JF, Shen W, Liu J, Qian L.
Cell Stem Cell. 2019 Jul 3;25(1):149-164.e9. doi: 10.1016/j.stem.2019.05.020. Epub 2019 Jun 20.
PubMed
Associated Plasmids |
| Pancreatic Ductal Organoids React Kras Dependent to the Removal of Tumor Suppressive Roadblocks. Perkhofer L, Engler M, Gout J, Arnold F, Morawe M, Breunig M, Seufferlein T, Kleger A, Frappart PO. Stem Cells Int. 2019 May 19;2019:2079742. doi: 10.1155/2019/2079742. eCollection 2019. PubMed |
| Alcohol Effects on Colon Epithelium are Time-Dependent. Bishehsari F, Zhang L, Voigt RM, Maltby N, Semsarieh B, Zorub E, Shaikh M, Wilber S, Armstrong AR, Mirbagheri SS, Preite NZ, Song P, Stornetta A, Balbo S, Forsyth CB, Keshavarzian A. Alcohol Clin Exp Res. 2019 Jun 25. doi: 10.1111/acer.14141. PubMed |
| CELF2 suppresses non-small cell lung carcinoma growth by inhibiting the PREX2-PTEN interaction. Yeung YT, Fan S, Lu B, Yin S, Yang S, Nie W, Wang M, Zhou L, Li T, Li X, Bode AM, Dong Z. Carcinogenesis. 2019 Jun 25. pii: 5523300. doi: 10.1093/carcin/bgz113. PubMed |
| Dysregulated Glial Differentiation in Schizophrenia May Be Relieved by Suppression of SMAD4- and REST-Dependent Signaling. Liu Z, Osipovitch M, Benraiss A, Huynh NPT, Foti R, Bates J, Chandler-Militello D, Findling RL, Tesar PJ, Nedergaard M, Windrem MS, Goldman SA. Cell Rep. 2019 Jun 25;27(13):3832-3843.e6. doi: 10.1016/j.celrep.2019.05.088. PubMed |
| Loss of the transcription factor RBPJ induces disease-promoting properties in brain pericytes. Dieguez-Hurtado R, Kato K, Giaimo BD, Nieminen-Kelha M, Arf H, Ferrante F, Bartkuhn M, Zimmermann T, Bixel MG, Eilken HM, Adams S, Borggrefe T, Vajkoczy P, Adams RH. Nat Commun. 2019 Jun 27;10(1):2817. doi: 10.1038/s41467-019-10643-w. PubMed |
| Nutrient availability shapes methionine metabolism in p16/MTAP-deleted cells. Sanderson SM, Mikhael PG, Ramesh V, Dai Z, Locasale JW. Sci Adv. 2019 Jun 26;5(6):eaav7769. doi: 10.1126/sciadv.aav7769. eCollection 2019 Jun. PubMed |
| Establishment of a system for screening autophagic flux regulators using a modified fluorescent reporter and CRISPR/Cas9. Yazawa R, Nishida Y, Aoyama S, Tanida I, Miyatsuka T, Suzuki L, Himuro M, Haruna H, Takubo N, Shimizu T, Watada H. Biochem Biophys Res Commun. 2019 Aug 27;516(3):686-692. doi: 10.1016/j.bbrc.2019.06.129. Epub 2019 Jun 26. PubMed |
| BACH1 Stabilization by Antioxidants Stimulates Lung Cancer Metastasis. Wiel C, Le Gal K, Ibrahim MX, Jahangir CA, Kashif M, Yao H, Ziegler DV, Xu X, Ghosh T, Mondal T, Kanduri C, Lindahl P, Sayin VI, Bergo MO. Cell. 2019 Jul 11;178(2):330-345.e22. doi: 10.1016/j.cell.2019.06.005. Epub 2019 Jun 27. PubMed |
| Functional Relevance of Interleukin-1 Receptor Inter-domain Flexibility for Cytokine Binding and Signaling. Ge J, Remesh SG, Hammel M, Pan S, Mahan AD, Wang S, Wang X. Structure. 2019 Aug 6;27(8):1296-1307.e5. doi: 10.1016/j.str.2019.05.011. Epub 2019 Jun 27. PubMed |
| Bmi1 Suppresses Adipogenesis in the Hematopoietic Stem Cell Niche. Hu T, Kitano A, Luu V, Dawson B, Hoegenauer KA, Lee BH, Nakada D. Stem Cell Reports. 2019 Sep 10;13(3):545-558. doi: 10.1016/j.stemcr.2019.05.027. Epub 2019 Jun 27. PubMed |
| SNAI2 3'untranslated region promotes the invasion of ovarian cancer cells by inducing MARCKS expression. Li J, Wang J, Yue H, Lu X. J Cancer. 2019 Jun 2;10(11):2480-2487. doi: 10.7150/jca.29489. eCollection 2019. PubMed |
| Overexpression of MicroRNA-148b-3p stimulates osteogenesis of human bone marrow-derived mesenchymal stem cells: the role of MicroRNA-148b-3p in osteogenesis. Mollazadeh S, Fazly Bazzaz BS, Neshati V, de Vries AAF, Naderi-Meshkin H, Mojarad M, Mirahmadi M, Neshati Z, Kerachian MA. BMC Med Genet. 2019 Jul 1;20(1):117. doi: 10.1186/s12881-019-0854-3. PubMed |
| An ErbB2/c-Src axis links bioenergetics with PRC2 translation to drive epigenetic reprogramming and mammary tumorigenesis. Smith HW, Hirukawa A, Sanguin-Gendreau V, Nandi I, Dufour CR, Zuo D, Tandoc K, Leibovitch M, Singh S, Rennhack JP, Swiatnicki M, Lavoie C, Papavasiliou V, Temps C, Carragher NO, Unciti-Broceta A, Savage P, Basik M, van Hoef V, Larsson O, Cooper CL, Vargas Calderon AC, Beith J, Millar E, Selinger C, Giguere V, Park M, Harris LN, Varadan V, Andrechek ER, O'Toole SA, Topisirovic I, Muller WJ. Nat Commun. 2019 Jul 1;10(1):2901. doi: 10.1038/s41467-019-10681-4. PubMed |
| Transmembrane insertases and N-glycosylation critically determine synthesis, trafficking and activity of the nonselective cation channel TRPC6. Talbot BE, Vandorpe DH, Stotter BR, Alper SL, Schlondorff JS. J Biol Chem. 2019 Jul 2. pii: RA119.008299. doi: 10.1074/jbc.RA119.008299. PubMed |
Human GBP1 is a microbe-specific gatekeeper of macrophage apoptosis and pyroptosis.
Fisch D, Bando H, Clough B, Hornung V, Yamamoto M, Shenoy AR, Frickel EM.
EMBO J. 2019 Jul 1;38(13):e100926. doi: 10.15252/embj.2018100926. Epub 2019 Jun 3.
PubMed
Associated Plasmids |
| Neuronal Soma-Derived Degradative Lysosomes Are Continuously Delivered to Distal Axons to Maintain Local Degradation Capacity. Farfel-Becker T, Roney JC, Cheng XT, Li S, Cuddy SR, Sheng ZH. Cell Rep. 2019 Jul 2;28(1):51-64.e4. doi: 10.1016/j.celrep.2019.06.013. PubMed |
| Cytokine Storm Combined with Humoral Immune Response Defect in Fatal Hemorrhagic Fever with Renal Syndrome Case, Tatarstan, Russia. Garanina E, Martynova E, Davidyuk Y, Kabwe E, Ivanov K, Titova A, Markelova M, Zhuravleva M, Cherepnev G, Shakirova VG, Khaertynova I, Tarlinton R, Rizvanov A, Khaiboullina S, Morzunov S. Viruses. 2019 Jul 2;11(7). pii: v11070601. doi: 10.3390/v11070601. PubMed |
| The metalloproteinase ADAM15 is upregulated by shear stress and promotes survival of endothelial cells. Babendreyer A, Molls L, Simons IM, Dreymueller D, Biller K, Jahr H, Denecke B, Boon RA, Bette S, Schnakenberg U, Ludwig A. J Mol Cell Cardiol. 2019 Jul 1;134:51-61. doi: 10.1016/j.yjmcc.2019.06.017. PubMed |
| Dephosphorylation of HDAC4 by PP2A-Bdelta unravels a new role for the HDAC4/MEF2 axis in myoblast fusion. Veloso A, Martin M, Bruyr J, O'Grady T, Deroanne C, Mottet D, Twizere JC, Cherrier T, Dequiedt F. Cell Death Dis. 2019 Jul 4;10(7):512. doi: 10.1038/s41419-019-1743-6. PubMed |
| Targeting hypoxia downstream signaling protein, CAIX, for CAR T-cell therapy against glioblastoma. Cui J, Zhang Q, Song Q, Wang H, Dmitriev P, Sun MY, Cao X, Wang Y, Guo L, Indig IH, Rosenblum JS, Ji C, Cao D, Yang K, Gilbert MR, Yao Y, Zhuang Z. Neuro Oncol. 2019 Nov 4;21(11):1436-1446. doi: 10.1093/neuonc/noz117. PubMed |
| PCIF1 Catalyzes m6Am mRNA Methylation to Regulate Gene Expression. Sendinc E, Valle-Garcia D, Dhall A, Chen H, Henriques T, Navarrete-Perea J, Sheng W, Gygi SP, Adelman K, Shi Y. Mol Cell. 2019 Jun 18. pii: S1097-2765(19)30402-2. doi: 10.1016/j.molcel.2019.05.030. PubMed |
| Forkhead box K2 promotes human colorectal cancer metastasis by upregulating ZEB1 and EGFR. Du F, Qiao C, Li X, Chen Z, Liu H, Wu S, Hu S, Qiu Z, Qian M, Tian D, Wu K, Fan D, Nie Y, Xia L. Theranostics. 2019 May 31;9(13):3879-3902. doi: 10.7150/thno.31716. eCollection 2019. PubMed |
| Covalent targeting of the vacuolar H(+)-ATPase activates autophagy via mTORC1 inhibition. Chung CY, Shin HR, Berdan CA, Ford B, Ward CC, Olzmann JA, Zoncu R, Nomura DK. Nat Chem Biol. 2019 Aug;15(8):776-785. doi: 10.1038/s41589-019-0308-4. Epub 2019 Jul 8. PubMed |
| Genomic and Transcriptomic Determinants of Therapy Resistance and Immune Landscape Evolution during Anti-EGFR Treatment in Colorectal Cancer. Woolston A, Khan K, Spain G, Barber LJ, Griffiths B, Gonzalez-Exposito R, Hornsteiner L, Punta M, Patil Y, Newey A, Mansukhani S, Davies MN, Furness A, Sclafani F, Peckitt C, Jimenez M, Kouvelakis K, Ranftl R, Begum R, Rana I, Thomas J, Bryant A, Quezada S, Wotherspoon A, Khan N, Fotiadis N, Marafioti T, Powles T, Lise S, Calvo F, Guettler S, von Loga K, Rao S, Watkins D, Starling N, Chau I, Sadanandam A, Cunningham D, Gerlinger M. Cancer Cell. 2019 Jul 8;36(1):35-50.e9. doi: 10.1016/j.ccell.2019.05.013. PubMed |
| Conserved Herpesvirus Protein Kinases Target SAMHD1 to Facilitate Virus Replication. Zhang K, Lv DW, Li R. Cell Rep. 2019 Jul 9;28(2):449-459.e5. doi: 10.1016/j.celrep.2019.04.020. PubMed |
| Quantitative characterization of 3D bioprinted structural elements under cell generated forces. Morley CD, Ellison ST, Bhattacharjee T, O'Bryan CS, Zhang Y, Smith KF, Kabb CP, Sebastian M, Moore GL, Schulze KD, Niemi S, Sawyer WG, Tran DD, Mitchell DA, Sumerlin BS, Flores CT, Angelini TE. Nat Commun. 2019 Jul 10;10(1):3029. doi: 10.1038/s41467-019-10919-1. PubMed |
| Acetylation of BMAL1 by TIP60 controls BRD4-P-TEFb recruitment to circadian promoters. Petkau N, Budak H, Zhou X, Oster H, Eichele G. Elife. 2019 Jul 11;8. pii: 43235. doi: 10.7554/eLife.43235. PubMed |
| The orphan nuclear receptor SHP regulates ER stress response by inhibiting XBP1s degradation. Sun S, Kelekar S, Kliewer SA, Mangelsdorf DJ. Genes Dev. 2019 Aug 1;33(15-16):1083-1094. doi: 10.1101/gad.326868.119. Epub 2019 Jul 11. PubMed |
| Inhibition of Anaplerotic Glutaminolysis Underlies Selenite Toxicity in Human Lung Cancer. Bruntz RC, Belshoff AC, Zhang Y, Macedo JKA, Higashi RM, Lane AN, Fan TW. Proteomics. 2019 Nov;19(21-22):e1800486. doi: 10.1002/pmic.201800486. Epub 2019 Sep 12. PubMed |
| Augmenting Immunotherapy Impact by Lowering Tumor TNF Cytotoxicity Threshold. Vredevoogd DW, Kuilman T, Ligtenberg MA, Boshuizen J, Stecker KE, de Bruijn B, Krijgsman O, Huang X, Kenski JCN, Lacroix R, Mezzadra R, Gomez-Eerland R, Yildiz M, Dagidir I, Apriamashvili G, Zandhuis N, van der Noort V, Visser NL, Blank CU, Altelaar M, Schumacher TN, Peeper DS. Cell. 2019 Jul 25;178(3):585-599.e15. doi: 10.1016/j.cell.2019.06.014. Epub 2019 Jul 11. PubMed |
Mechanisms of Progression of Myeloid Preleukemia to Transformed Myeloid Leukemia in Children with Down Syndrome.
Labuhn M, Perkins K, Matzk S, Varghese L, Garnett C, Papaemmanuil E, Metzner M, Kennedy A, Amstislavskiy V, Risch T, Bhayadia R, Samulowski D, Hernandez DC, Stoilova B, Iotchkova V, Oppermann U, Scheer C, Yoshida K, Schwarzer A, Taub JW, Crispino JD, Weiss MJ, Hayashi Y, Taga T, Ito E, Ogawa S, Reinhardt D, Yaspo ML, Campbell PJ, Roberts I, Constantinescu SN, Vyas P, Heckl D, Klusmann JH.
Cancer Cell. 2019 Aug 12;36(2):123-138.e10. doi: 10.1016/j.ccell.2019.06.007. Epub 2019 Jul 11.
PubMed
Associated Plasmids |
Engineering Forward Genetics into Cultured Cancer Cells for Chemical Target Identification.
Povedano JM, Liou J, Wei D, Srivatsav A, Kim J, Xie Y, Nijhawan D, McFadden DG.
Cell Chem Biol. 2019 Sep 19;26(9):1315-1321.e3. doi: 10.1016/j.chembiol.2019.06.006. Epub 2019 Jul 11.
PubMed
Associated Plasmids |
| SET Domain-Containing Protein 4 Epigenetically Controls Breast Cancer Stem Cell Quiescence. Ye S, Ding YF, Jia WH, Liu XL, Feng JY, Zhu Q, Cai SL, Yang YS, Lu QY, Huang XT, Yang JS, Jia SN, Ding GP, Wang YH, Zhou JJ, Chen YD, Yang WJ. Cancer Res. 2019 Sep 15;79(18):4729-4743. doi: 10.1158/0008-5472.CAN-19-1084. Epub 2019 Jul 15. PubMed |
| Membrane protein-regulated networks across human cancers. Lin CY, Lee CH, Chuang YH, Lee JY, Chiu YY, Wu Lee YH, Jong YJ, Hwang JK, Huang SH, Chen LC, Wu CH, Tu SH, Ho YS, Yang JM. Nat Commun. 2019 Jul 16;10(1):3131. doi: 10.1038/s41467-019-10920-8. PubMed |
Pooled library screening with multiplexed Cpf1 library.
Liu J, Srinivasan S, Li CY, Ho IL, Rose J, Shaheen M, Wang G, Yao W, Deem A, Bristow C, Hart T, Draetta G.
Nat Commun. 2019 Jul 17;10(1):3144. doi: 10.1038/s41467-019-10963-x.
PubMed
Associated Plasmids |
| Dynamic change of electrostatic field in TMEM16F permeation pathway shifts its ion selectivity. Ye W, Han TW, He M, Jan YN, Jan LY. Elife. 2019 Jul 18;8. pii: 45187. doi: 10.7554/eLife.45187. PubMed |
| The transporters SLC35A1 and SLC30A1 play opposite roles in cell survival upon VSV virus infection. Moskovskich A, Goldmann U, Kartnig F, Lindinger S, Konecka J, Fiume G, Girardi E, Superti-Furga G. Sci Rep. 2019 Jul 18;9(1):10471. doi: 10.1038/s41598-019-46952-9. PubMed |
| Loss of FGL1 induces epithelialmesenchymal transition and angiogenesis in LKB1 mutant lung adenocarcinoma. Bie F, Wang G, Qu X, Wang Y, Huang C, Wang Y, Du J. Int J Oncol. 2019 Sep;55(3):697-707. doi: 10.3892/ijo.2019.4838. Epub 2019 Jul 15. PubMed |
| CRISPR-Cas9 Mediated TSPO Gene Knockout alters Respiration and Cellular Metabolism in Human Primary Microglia Cells. Milenkovic VM, Slim D, Bader S, Koch V, Heinl ES, Alvarez-Carbonell D, Nothdurfter C, Rupprecht R, Wetzel CH. Int J Mol Sci. 2019 Jul 9;20(13). pii: ijms20133359. doi: 10.3390/ijms20133359. PubMed |
| Circular RNA circRHOT1 promotes hepatocellular carcinoma progression by initiation of NR2F6 expression. Wang L, Long H, Zheng Q, Bo X, Xiao X, Li B. Mol Cancer. 2019 Jul 19;18(1):119. doi: 10.1186/s12943-019-1046-7. PubMed |
| A kinome-wide shRNA screen uncovers vaccinia-related kinase 3 (VRK3) as an essential gene for diffuse intrinsic pontine glioma survival. Silva-Evangelista C, Barret E, Menez V, Merlevede J, Kergrohen T, Saccasyn A, Oberlin E, Puget S, Beccaria K, Grill J, Castel D, Debily MA. Oncogene. 2019 Sep;38(38):6479-6490. doi: 10.1038/s41388-019-0884-5. Epub 2019 Jul 19. PubMed |
| PI31 Is an Adaptor Protein for Proteasome Transport in Axons and Required for Synaptic Development. Liu K, Jones S, Minis A, Rodriguez J, Molina H, Steller H. Dev Cell. 2019 Aug 19;50(4):509-524.e10. doi: 10.1016/j.devcel.2019.06.009. Epub 2019 Jul 18. PubMed |
| Essential genes shape cancer genomes through linear limitation of homozygous deletions. Pertesi M, Ekdahl L, Palm A, Johnsson E, Jarvstrat L, Wihlborg AK, Nilsson B. Commun Biol. 2019 Jul 19;2:262. doi: 10.1038/s42003-019-0517-0. eCollection 2019. PubMed |
| PUMILIO, but not RBMX, binding is required for regulation of genomic stability by noncoding RNA NORAD. Elguindy MM, Kopp F, Goodarzi M, Rehfeld F, Thomas A, Chang TC, Mendell JT. Elife. 2019 Jul 25;8. pii: 48625. doi: 10.7554/eLife.48625. PubMed |
Towards a surrogate system to express human lipid binding TCRs.
Wang R, Pscheid R, Ghumra A, Kan LYL, Cochrane S, Fairclough L, Alcocer MJC.
Biotechnol Lett. 2019 Oct;41(10):1095-1104. doi: 10.1007/s10529-019-02713-2. Epub 2019 Jul 26.
PubMed
Associated Plasmids |
| Human Artificial Chromosomes that Bypass Centromeric DNA. Logsdon GA, Gambogi CW, Liskovykh MA, Barrey EJ, Larionov V, Miga KH, Heun P, Black BE. Cell. 2019 Jul 25;178(3):624-639.e19. doi: 10.1016/j.cell.2019.06.006. PubMed |
The AMPK-Related Kinases SIK1 and SIK3 Mediate Key Tumor-Suppressive Effects of LKB1 in NSCLC.
Hollstein PE, Eichner LJ, Brun SN, Kamireddy A, Svensson RU, Vera LI, Ross DS, Rymoff TJ, Hutchins A, Galvez HM, Williams AE, Shokhirev MN, Screaton RA, Berdeaux R, Shaw RJ.
Cancer Discov. 2019 Nov;9(11):1606-1627. doi: 10.1158/2159-8290.CD-18-1261. Epub 2019 Jul 26.
PubMed
Associated Plasmids |
| Stabilizing heterochromatin by DGCR8 alleviates senescence and osteoarthritis. Deng L, Ren R, Liu Z, Song M, Li J, Wu Z, Ren X, Fu L, Li W, Zhang W, Guillen P, Izpisua Belmonte JC, Chan P, Qu J, Liu GH. Nat Commun. 2019 Jul 26;10(1):3329. doi: 10.1038/s41467-019-10831-8. PubMed |
| Activation of PARP-1 by snoRNAs Controls Ribosome Biogenesis and Cell Growth via the RNA Helicase DDX21. Kim DS, Camacho CV, Nagari A, Malladi VS, Challa S, Kraus WL. Mol Cell. 2019 Sep 19;75(6):1270-1285.e14. doi: 10.1016/j.molcel.2019.06.020. Epub 2019 Jul 24. PubMed |
| Construction of a mavs-inactivated MDCK cell line for facilitating the propagation of canine distemper virus (CDV). Cai C, Wang X, Zhao Y, Yi C, Jin Z, Zhang A, Han L. Mol Immunol. 2019 Oct;114:133-138. doi: 10.1016/j.molimm.2019.06.013. Epub 2019 Jul 25. PubMed |
| Structural Basis for Target-Directed MicroRNA Degradation. Sheu-Gruttadauria J, Pawlica P, Klum SM, Wang S, Yario TA, Schirle Oakdale NT, Steitz JA, MacRae IJ. Mol Cell. 2019 Sep 19;75(6):1243-1255.e7. doi: 10.1016/j.molcel.2019.06.019. Epub 2019 Jul 25. PubMed |
| AAGAB Controls AP2 Adaptor Assembly in Clathrin-Mediated Endocytosis. Gulbranson DR, Crisman L, Lee M, Ouyang Y, Menasche BL, Demmitt BA, Wan C, Nomura T, Ye Y, Yu H, Shen J. Dev Cell. 2019 Aug 19;50(4):436-446.e5. doi: 10.1016/j.devcel.2019.06.013. Epub 2019 Jul 25. PubMed |
| Bilirubin Links Heme Metabolism to Neuroprotection by Scavenging Superoxide. Vasavda C, Kothari R, Malla AP, Tokhunts R, Lin A, Ji M, Ricco C, Xu R, Saavedra HG, Sbodio JI, Snowman AM, Albacarys L, Hester L, Sedlak TW, Paul BD, Snyder SH. Cell Chem Biol. 2019 Oct 17;26(10):1450-1460.e7. doi: 10.1016/j.chembiol.2019.07.006. Epub 2019 Jul 25. PubMed |
| TREM1/3 Deficiency Impairs Tissue Repair After Acute Kidney Injury and Mitochondrial Metabolic Flexibility in Tubular Epithelial Cells. Tammaro A, Scantlebery AML, Rampanelli E, Borrelli C, Claessen N, Butter LM, Soriani A, Colonna M, Leemans JC, Dessing MC, Florquin S. Front Immunol. 2019 Jul 9;10:1469. doi: 10.3389/fimmu.2019.01469. eCollection 2019. PubMed |
| A Cancer-Associated Missense Mutation in PP2A-Aalpha Increases Centrosome Clustering during Mitosis. Antao NV, Marcet-Ortega M, Cifani P, Kentsis A, Foley EA. iScience. 2019 Sep 27;19:74-82. doi: 10.1016/j.isci.2019.07.018. Epub 2019 Jul 17. PubMed |
| Analysis of Retinoic Acid Receptor Signaling in Colorectal Cancer. Imajo M. Methods Mol Biol. 2019;2019:85-93. doi: 10.1007/978-1-4939-9585-1_6. PubMed |
| TSPAN12 Precedes Tumor Proliferation by Cell Cycle Control in Ovarian Cancer. Ji G, Liang H, Wang F, Wang N, Fu S, Cui X. Mol Cells. 2019 Jul 31;42(7):557-567. doi: 10.14348/molcells.2019.0015. PubMed |
| CRISPR/Cas9 Screens Reveal Multiple Layers of B cell CD40 Regulation. Jiang C, Trudeau SJ, Cheong TC, Guo R, Teng M, Wang LW, Wang Z, Pighi C, Gautier-Courteille C, Ma Y, Jiang S, Wang C, Zhao B, Paillard L, Doench JG, Chiarle R, Gewurz BE. Cell Rep. 2019 Jul 30;28(5):1307-1322.e8. doi: 10.1016/j.celrep.2019.06.079. PubMed |
| Mapping cis-regulatory chromatin contacts in neural cells links neuropsychiatric disorder risk variants to target genes. Song M, Yang X, Ren X, Maliskova L, Li B, Jones IR, Wang C, Jacob F, Wu K, Traglia M, Tam TW, Jamieson K, Lu SY, Ming GL, Li Y, Yao J, Weiss LA, Dixon JR, Judge LM, Conklin BR, Song H, Gan L, Shen Y. Nat Genet. 2019 Aug;51(8):1252-1262. doi: 10.1038/s41588-019-0472-1. Epub 2019 Jul 31. PubMed |
| Novel p97/VCP inhibitor induces endoplasmic reticulum stress and apoptosis in both bortezomib-sensitive and -resistant multiple myeloma cells. Nishimura N, Radwan MO, Amano M, Endo S, Fujii E, Hayashi H, Ueno S, Ueno N, Tatetsu H, Hata H, Okamoto Y, Otsuka M, Mitsuya H, Matsuoka M, Okuno Y. Cancer Sci. 2019 Oct;110(10):3275-3287. doi: 10.1111/cas.14154. Epub 2019 Aug 14. PubMed |
| Ifit1 regulates norovirus infection and enhances the interferon response in murine macrophage-like cells. Mears HV, Emmott E, Chaudhry Y, Hosmillo M, Goodfellow IG, Sweeney TR. Wellcome Open Res. 2019 May 15;4:82. doi: 10.12688/wellcomeopenres.15223.1. eCollection 2019. PubMed |
| Heterozygous Mutations in SMARCA2 Reprogram the Enhancer Landscape by Global Retargeting of SMARCA4. Gao F, Elliott NJ, Ho J, Sharp A, Shokhirev MN, Hargreaves DC. Mol Cell. 2019 Sep 5;75(5):891-904.e7. doi: 10.1016/j.molcel.2019.06.024. Epub 2019 Jul 30. PubMed |
| Kaposi's Sarcoma-Associated Herpesvirus Lytic Replication Interferes with mTORC1 Regulation of Autophagy and Viral Protein Synthesis. Pringle ES, Robinson CA, McCormick C. J Virol. 2019 Oct 15;93(21). pii: JVI.00854-19. doi: 10.1128/JVI.00854-19. Print 2019 Nov 1. PubMed |
| CRISPR-based genomic loci labeling revealed ordered spatial organization of chromatin in living diploid human cells. Guo DG, Wang DB, Liu C, Lu S, Hou Y, Zhang XE. Biochim Biophys Acta Mol Cell Res. 2019 Dec;1866(12):118518. doi: 10.1016/j.bbamcr.2019.07.013. Epub 2019 Jul 31. PubMed |
| Coagulant activity of recombinant human factor VII produced by lentiviral human F7 gene transfer in immortalized hepatocyte-like cell line. Pongjantarasatian S, Kadegasem P, Sasanakul W, Sa-Ngiamsuntorn K, Borwornpinyo S, Sirachainan N, Chuansumrit A, Tanratana P, Hongeng S. PLoS One. 2019 Aug 5;14(8):e0220825. doi: 10.1371/journal.pone.0220825. eCollection 2019. PubMed |
| Elevated UCP1 levels are sufficient to improve glucose uptake in human white adipocytes. Tews D, Pula T, Funcke JB, Jastroch M, Keuper M, Debatin KM, Wabitsch M, Fischer-Posovszky P. Redox Biol. 2019 Sep;26:101286. doi: 10.1016/j.redox.2019.101286. Epub 2019 Jul 27. PubMed |
| The Kaposi's Sarcoma-Associated Herpesvirus Protein ORF42 Is Required for Efficient Virion Production and Expression of Viral Proteins. Butnaru M, Gaglia MM. Viruses. 2019 Aug 2;11(8). pii: v11080711. doi: 10.3390/v11080711. PubMed |
| 3D bioprinted endometrial stem cells on melt electrospun poly epsilon-caprolactone mesh for pelvic floor application promote anti-inflammatory responses in mice. Paul K, Darzi S, McPhee G, Del Borgo MP, Werkmeister JA, Gargett CE, Mukherjee S. Acta Biomater. 2019 Oct 1;97:162-176. doi: 10.1016/j.actbio.2019.08.003. Epub 2019 Aug 3. PubMed |
| SAMHD1 Regulates Human Papillomavirus 16-Induced Cell Proliferation and Viral Replication during Differentiation of Keratinocytes. James CD, Prabhakar AT, Otoa R, Evans MR, Wang X, Bristol ML, Zhang K, Li R, Morgan IM. mSphere. 2019 Aug 7;4(4). pii: 4/4/e00448-19. doi: 10.1128/mSphere.00448-19. PubMed |
| PORCN inhibition synergizes with PI3K/mTOR inhibition in Wnt-addicted cancers. Zhong Z, Sepramaniam S, Chew XH, Wood K, Lee MA, Madan B, Virshup DM. Oncogene. 2019 Oct;38(40):6662-6677. doi: 10.1038/s41388-019-0908-1. Epub 2019 Aug 7. PubMed |
| Slug and Snail have differential effects in directing colonic epithelial wound healing and partially mediate the restitutive effects of butyrate. Swain SD, Grifka-Walk HN, Gripentrog J, Lehmann M, Deuling B, Jenkins B, Liss H, Blaseg N, Bimczok D, Kominsky DJ. Am J Physiol Gastrointest Liver Physiol. 2019 Oct 1;317(4):G531-G544. doi: 10.1152/ajpgi.00071.2019. Epub 2019 Aug 8. PubMed |
| Hotspot SF3B1 mutations induce metabolic reprogramming and vulnerability to serine deprivation. Dalton WB, Helmenstine E, Walsh N, Gondek LP, Kelkar DS, Read A, Natrajan R, Christenson ES, Roman B, Das S, Zhao L, Leone RD, Shinn D, Groginski T, Madugundu AK, Patil A, Zabransky DJ, Medford A, Lee J, Cole AJ, Rosen M, Thakar M, Ambinder A, Donaldson J, DeZern AE, Cravero K, Chu D, Madero-Marroquin R, Pandey A, Hurley PJ, Lauring J, Park BH. J Clin Invest. 2019 Aug 8;130:4708-4723. doi: 10.1172/JCI125022. PubMed |
| Dephosphorylation activates the interferon-stimulated Schlafen family member 11 in the DNA damage response. Malone D, Lardelli RM, Li M, David M. J Biol Chem. 2019 Oct 4;294(40):14674-14685. doi: 10.1074/jbc.RA118.006588. Epub 2019 Aug 8. PubMed |
| Structural basis for AcrVA4 inhibition of specific CRISPR-Cas12a. Knott GJ, Cress BF, Liu JJ, Thornton BW, Lew RJ, Al-Shayeb B, Rosenberg DJ, Hammel M, Adler BA, Lobba MJ, Xu M, Arkin AP, Fellmann C, Doudna JA. Elife. 2019 Aug 9;8. pii: 49110. doi: 10.7554/eLife.49110. PubMed |
The Oncogenic Action of NRF2 Depends on De-glycation by Fructosamine-3-Kinase.
Sanghvi VR, Leibold J, Mina M, Mohan P, Berishaj M, Li Z, Miele MM, Lailler N, Zhao C, de Stanchina E, Viale A, Akkari L, Lowe SW, Ciriello G, Hendrickson RC, Wendel HG.
Cell. 2019 Aug 8;178(4):807-819.e21. doi: 10.1016/j.cell.2019.07.031.
PubMed
Associated Plasmids |
| MYC competes with MiT/TFE in regulating lysosomal biogenesis and autophagy through an epigenetic rheostat. Annunziata I, van de Vlekkert D, Wolf E, Finkelstein D, Neale G, Machado E, Mosca R, Campos Y, Tillman H, Roussel MF, Andrew Weesner J, Ellen Fremuth L, Qiu X, Han MJ, Grosveld GC, d'Azzo A. Nat Commun. 2019 Aug 9;10(1):3623. doi: 10.1038/s41467-019-11568-0. PubMed |
| A Pliable Mediator Acts as a Functional Rather Than an Architectural Bridge between Promoters and Enhancers. El Khattabi L, Zhao H, Kalchschmidt J, Young N, Jung S, Van Blerkom P, Kieffer-Kwon P, Kieffer-Kwon KR, Park S, Wang X, Krebs J, Tripathi S, Sakabe N, Sobreira DR, Huang SC, Rao SSP, Pruett N, Chauss D, Sadler E, Lopez A, Nobrega MA, Aiden EL, Asturias FJ, Casellas R. Cell. 2019 Aug 22;178(5):1145-1158.e20. doi: 10.1016/j.cell.2019.07.011. Epub 2019 Aug 8. PubMed |
| Oct4 and Hnf4alpha-induced hepatic stem cells ameliorate chronic liver injury in liver fibrosis model. Park MR, Wong MS, Arauzo-Bravo MJ, Lee H, Nam D, Park SY, Seo HD, Lee SM, Zeilhofer HF, Zaehres H, Scholer HR, Kim JB. PLoS One. 2019 Aug 12;14(8):e0221085. doi: 10.1371/journal.pone.0221085. eCollection 2019. PubMed |
| KH-Type Splicing Regulatory Protein Controls Colorectal Cancer Cell Growth and Modulates the Tumor Microenvironment. Caiazza F, Oficjalska K, Tosetto M, Phelan JJ, Noonan S, Martin P, Killick K, Breen L, O'Neill F, Nolan B, Furney S, Power R, Fennelly D, Craik CS, O'Sullivan J, Sheahan K, Doherty GA, Ryan EJ. Am J Pathol. 2019 Oct;189(10):1916-1932. doi: 10.1016/j.ajpath.2019.07.004. Epub 2019 Aug 9. PubMed |
| CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan. Vennin C, Melenec P, Rouet R, Nobis M, Cazet AS, Murphy KJ, Herrmann D, Reed DA, Lucas MC, Warren SC, Elgundi Z, Pinese M, Kalna G, Roden D, Samuel M, Zaratzian A, Grey ST, Da Silva A, Leung W, Mathivanan S, Wang Y, Braithwaite AW, Christ D, Benda A, Parkin A, Phillips PA, Whitelock JM, Gill AJ, Sansom OJ, Croucher DR, Parker BL, Pajic M, Morton JP, Cox TR, Timpson P. Nat Commun. 2019 Aug 12;10(1):3637. doi: 10.1038/s41467-019-10968-6. PubMed |
Identification of a factor controlling lysosomal homeostasis using a novel lysosomal trafficking probe.
Ishii S, Matsuura A, Itakura E.
Sci Rep. 2019 Aug 12;9(1):11635. doi: 10.1038/s41598-019-48131-2.
PubMed
Associated Plasmids |
| Imaging Single mRNA Molecules in Mammalian Cells Using an Optimized MS2-MCP System. Vera M, Tutucci E, Singer RH. Methods Mol Biol. 2019;2038:3-20. doi: 10.1007/978-1-4939-9674-2_1. PubMed |
| MRTF-A controls myofibroblastic differentiation of human multipotent stromal cells and their tumour-supporting function in xenograft models. Werner S, Lutzkendorf J, Muller T, Muller LP, Posern G. Sci Rep. 2019 Aug 13;9(1):11725. doi: 10.1038/s41598-019-48142-z. PubMed |
| MRP4 sustains Wnt/beta-catenin signaling for pregnancy, endometriosis and endometrial cancer. Chen JJ, Xiao ZJ, Meng X, Wang Y, Yu MK, Huang WQ, Sun X, Chen H, Duan YG, Jiang X, Wong MP, Chan HC, Zou F, Ruan YC. Theranostics. 2019 Jul 9;9(17):5049-5064. doi: 10.7150/thno.32097. eCollection 2019. PubMed |
| The long noncoding RNA CHROME regulates cholesterol homeostasis in primate. Hennessy EJ, van Solingen C, Scacalossi KR, Ouimet M, Afonso MS, Prins J, Koelwyn GJ, Sharma M, Ramkhelawon B, Carpenter S, Busch A, Chernogubova E, Matic LP, Hedin U, Maegdefessel L, Caffrey BE, Hussein MA, Ricci EP, Temel RE, Garabedian MJ, Berger JS, Vickers KC, Kanke M, Sethupathy P, Teupser D, Holdt LM, Moore KJ. Nat Metab. 2019 Jan;1(1):98-110. doi: 10.1038/s42255-018-0004-9. Epub 2018 Dec 3. PubMed |
| p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas. Hsieh MH, Choe JH, Gadhvi J, Kim YJ, Arguez MA, Palmer M, Gerold H, Nowak C, Do H, Mazambani S, Knighton JK, Cha M, Goodwin J, Kang MK, Jeong JY, Lee SY, Faubert B, Xuan Z, Abel ED, Scafoglio C, Shackelford DB, Minna JD, Singh PK, Shulaev V, Bleris L, Hoyt K, Kim J, Inoue M, DeBerardinis RJ, Kim TH, Kim JW. Cell Rep. 2019 Aug 13;28(7):1860-1878.e9. doi: 10.1016/j.celrep.2019.07.027. PubMed |
| A New MicroRNA Cluster Involved in the Reprogramming to a Pluripotent State. Sherstyuk VV, Davletshina GI, Vyatkin YV, Shtokalo DN, Vlasov VV, Zakian SM. Acta Naturae. 2019 Apr-Jun;11(2):92-97. doi: 10.32607/20758251-2019-11-2-92-97. PubMed |
| TRPC6 Binds to and Activates Calpain, Independent of Its Channel Activity, and Regulates Podocyte Cytoskeleton, Cell Adhesion, and Motility. Farmer LK, Rollason R, Whitcomb DJ, Ni L, Goodliff A, Lay AC, Birnbaumer L, Heesom KJ, Xu SZ, Saleem MA, Welsh GI. J Am Soc Nephrol. 2019 Oct;30(10):1910-1924. doi: 10.1681/ASN.2018070729. Epub 2019 Aug 15. PubMed |
| The synthesis of branched-chain fatty acids is limited by enzymatic decarboxylation of ethyl- and methylmalonyl-CoA. Dewulf JP, Gerin I, Rider MH, Veiga-da-Cunha M, Van Schaftingen E, Bommer GT. Biochem J. 2019 Aug 30;476(16):2427-2447. doi: 10.1042/BCJ20190500. PubMed |
| CXCL14 suppresses human papillomavirus-associated head and neck cancer through antigen-specific CD8(+) T-cell responses by upregulating MHC-I expression. Westrich JA, Vermeer DW, Silva A, Bonney S, Berger JN, Cicchini L, Greer RO, Song JI, Raben D, Slansky JE, Lee JH, Spanos WC, Pyeon D. Oncogene. 2019 Nov;38(46):7166-7180. doi: 10.1038/s41388-019-0911-6. Epub 2019 Aug 15. PubMed |
| Cancer Cell-targeted and Activatable Photoimmunotherapy Spares T Cells in a 3D Coculture Model. Kercher EM, Nath S, Rizvi I, Spring BQ. Photochem Photobiol. 2019 Aug 19. doi: 10.1111/php.13153. PubMed |
| Establishment and evaluation of a PRRSV-sensitive porcine endometrial epithelial cell line by transfecting SV40 large T antigen. Zhang K, Li H, Dong S, Liu Y, Wang D, Liu H, Su F, Ge L, Jiang Y. BMC Vet Res. 2019 Aug 19;15(1):299. doi: 10.1186/s12917-019-2051-1. PubMed |
| Systematic characterization of BAF mutations provides insights into intracomplex synthetic lethalities in human cancers. Schick S, Rendeiro AF, Runggatscher K, Ringler A, Boidol B, Hinkel M, Majek P, Vulliard L, Penz T, Parapatics K, Schmidl C, Menche J, Boehmelt G, Petronczki M, Muller AC, Bock C, Kubicek S. Nat Genet. 2019 Sep;51(9):1399-1410. doi: 10.1038/s41588-019-0477-9. Epub 2019 Aug 19. PubMed |
| Toll-like receptor mediated inflammation requires FASN-dependent MYD88 palmitoylation. Kim YC, Lee SE, Kim SK, Jang HD, Hwang I, Jin S, Hong EB, Jang KS, Kim HS. Nat Chem Biol. 2019 Sep;15(9):907-916. doi: 10.1038/s41589-019-0344-0. Epub 2019 Aug 19. PubMed |
| Essential thrombocytosis attributed to JAK2-T875N germline mutation. Yoshimitsu M, Hachiman M, Uchida Y, Arima N, Arai A, Kamada Y, Shide K, Ito M, Shimoda K, Ishitsuka K. Int J Hematol. 2019 Nov;110(5):584-590. doi: 10.1007/s12185-019-02725-8. Epub 2019 Aug 19. PubMed |
| Genomic Resolution of DLX-Orchestrated Transcriptional Circuits Driving Development of Forebrain GABAergic Neurons. Lindtner S, Catta-Preta R, Tian H, Su-Feher L, Price JD, Dickel DE, Greiner V, Silberberg SN, McKinsey GL, McManus MT, Pennacchio LA, Visel A, Nord AS, Rubenstein JLR. Cell Rep. 2019 Aug 20;28(8):2048-2063.e8. doi: 10.1016/j.celrep.2019.07.022. PubMed |
| Identifying chemogenetic interactions from CRISPR screens with drugZ. Colic M, Wang G, Zimmermann M, Mascall K, McLaughlin M, Bertolet L, Lenoir WF, Moffat J, Angers S, Durocher D, Hart T. Genome Med. 2019 Aug 22;11(1):52. doi: 10.1186/s13073-019-0665-3. PubMed |
| Single-Nucleotide-Resolution Computing and Memory in Living Cells. Farzadfard F, Gharaei N, Higashikuni Y, Jung G, Cao J, Lu TK. Mol Cell. 2019 Aug 22;75(4):769-780.e4. doi: 10.1016/j.molcel.2019.07.011. PubMed |
| Plasticity of the Cullin-RING Ligase Repertoire Shapes Sensitivity to Ligand-Induced Protein Degradation. Mayor-Ruiz C, Jaeger MG, Bauer S, Brand M, Sin C, Hanzl A, Mueller AC, Menche J, Winter GE. Mol Cell. 2019 Aug 22;75(4):849-858.e8. doi: 10.1016/j.molcel.2019.07.013. PubMed |
| A distinct subset of FcgammaRI-expressing Th1 cells exert antibody-mediated cytotoxic activity. Rasoulouniriana D, Santana-Magal N, Gutwillig A, Farhat-Younis L, Wine Y, Saperia C, Tal L, Gutman H, Tsivian A, Brenner R, Bandora EA, Reticker-Flynn NE, Rider P, Carmi Y. J Clin Invest. 2019 Oct 1;129(10):4151-4164. doi: 10.1172/JCI127590. PubMed |
| Toxoplasma gondii activates a Syk-CARD9-NF-kappaB signaling axis and gasdermin D-independent release of IL-1beta during infection of primary human monocytes. Pandori WJ, Lima TS, Mallya S, Kao TH, Gov L, Lodoen MB. PLoS Pathog. 2019 Aug 26;15(8):e1007923. doi: 10.1371/journal.ppat.1007923. eCollection 2019 Aug. PubMed |
| Increased expression of heme-binding protein 1 early in Alzheimer's disease is linked to neurotoxicity. Yagensky O, Kohansal-Nodehi M, Gunaseelan S, Rabe T, Zafar S, Zerr I, Hartig W, Urlaub H, Chua JJ. Elife. 2019 Aug 27;8. pii: 47498. doi: 10.7554/eLife.47498. PubMed |
| Albumin evokes Ca(2+)-induced cell oxidative stress and apoptosis through TRPM2 channel in renal collecting duct cells reduced by curcumin. Naziroglu M, Cig B, Yazgan Y, Schwaerzer GK, Theilig F, Pecze L. Sci Rep. 2019 Aug 27;9(1):12403. doi: 10.1038/s41598-019-48716-x. PubMed |
| ZNNT1 long noncoding RNA induces autophagy to inhibit tumorigenesis of uveal melanoma by regulating key autophagy gene expression. Li P, He J, Yang Z, Ge S, Zhang H, Zhong Q, Fan X. Autophagy. 2019 Sep 3:1-14. doi: 10.1080/15548627.2019.1659614. PubMed |
| WNT5B governs the phenotype of basal-like breast cancer by activating WNT signaling. Jiang S, Zhang M, Zhang Y, Zhou W, Zhu T, Ruan Q, Chen H, Fang J, Zhou F, Sun J, Yang X. Cell Commun Signal. 2019 Aug 28;17(1):109. doi: 10.1186/s12964-019-0419-2. PubMed |
| Concomitant targeting of Hedgehog signaling and MCL-1 synergistically induces cell death in Hedgehog-driven cancer cells. Meister MT, Boedicker C, Linder B, Kogel D, Klingebiel T, Fulda S. Cancer Lett. 2019 Nov 28;465:1-11. doi: 10.1016/j.canlet.2019.08.012. Epub 2019 Aug 26. PubMed |
| Phosphoinositide 3-kinase delta inactivation prevents vitreous-induced activation of AKT/MDM2/p53 and migration of retinal pigment epithelial cells. Han H, Chen N, Huang X, Liu B, Tian J, Lei H. J Biol Chem. 2019 Oct 18;294(42):15408-15417. doi: 10.1074/jbc.RA119.010130. Epub 2019 Aug 29. PubMed |
| Tanycytic TSPO inhibition induces lipophagy to regulate lipid metabolism and improve energy balance. Kim S, Kim N, Park S, Jeon Y, Lee J, Yoo SJ, Lee JW, Moon C, Yu SW, Kim EK. Autophagy. 2019 Aug 30:1-21. doi: 10.1080/15548627.2019.1659616. PubMed |
| Poly(ADP-Ribose) Polymerase 2 Recruits Replication Protein A to Sites of LINE-1 Integration to Facilitate Retrotransposition. Miyoshi T, Makino T, Moran JV. Mol Cell. 2019 Sep 19;75(6):1286-1298.e12. doi: 10.1016/j.molcel.2019.07.018. Epub 2019 Aug 28. PubMed |
| Sema3a-Nrp1 Signaling Mediates Fast-Twitch Myofiber Specificity of Tw2(+) Cells. Li S, Karri D, Sanchez-Ortiz E, Jaichander P, Bassel-Duby R, Liu N, Olson EN. Dev Cell. 2019 Oct 7;51(1):89-98.e4. doi: 10.1016/j.devcel.2019.08.002. Epub 2019 Aug 29. PubMed |
| Centrosome loss results in an unstable genome and malignant prostate tumors. Wang M, Nagle RB, Knudsen BS, Cress AE, Rogers GC. Oncogene. 2020 Jan;39(2):399-413. doi: 10.1038/s41388-019-0995-z. Epub 2019 Sep 2. PubMed |
| FAK activity sustains intrinsic and acquired ovarian cancer resistance to platinum chemotherapy. Diaz Osterman CJ, Ozmadenci D, Kleinschmidt EG, Taylor KN, Barrie AM, Jiang S, Bean LM, Sulzmaier FJ, Jean C, Tancioni I, Anderson K, Uryu S, Cordasco EA, Li J, Chen XL, Fu G, Ojalill M, Rappu P, Heino J, Mark AM, Xu G, Fisch KM, Kolev VN, Weaver DT, Pachter JA, Gyorffy B, McHale MT, Connolly DC, Molinolo A, Stupack DG, Schlaepfer DD. Elife. 2019 Sep 3;8. pii: 47327. doi: 10.7554/eLife.47327. PubMed |
| Residual apoptotic activity of a tumorigenic p53 mutant improves cancer therapy responses. Timofeev O, Klimovich B, Schneikert J, Wanzel M, Pavlakis E, Noll J, Mutlu S, Elmshauser S, Nist A, Mernberger M, Lamp B, Wenig U, Brobeil A, Gattenlohner S, Kohler K, Stiewe T. EMBO J. 2019 Oct 15;38(20):e102096. doi: 10.15252/embj.2019102096. Epub 2019 Sep 4. PubMed |
| Proteomic Analysis Identifies Membrane Proteins Dependent on the ER Membrane Protein Complex. Tian S, Wu Q, Zhou B, Choi MY, Ding B, Yang W, Dong M. Cell Rep. 2019 Sep 3;28(10):2517-2526.e5. doi: 10.1016/j.celrep.2019.08.006. PubMed |
| New factors for protein transport identified by a genome-wide CRISPRi screen in mammalian cells. Bassaganyas L, Popa SJ, Horlbeck M, Puri C, Stewart SE, Campelo F, Ashok A, Butnaru CM, Brouwers N, Heydari K, Ripoche J, Weissman J, Rubinsztein DC, Schekman R, Malhotra V, Moreau K, Villeneuve J. J Cell Biol. 2019 Nov 4;218(11):3861-3879. doi: 10.1083/jcb.201902028. Epub 2019 Sep 5. PubMed |
| mTORC1 Activation Requires DRAM-1 by Facilitating Lysosomal Amino Acid Efflux. Beaumatin F, O'Prey J, Barthet VJA, Zunino B, Parvy JP, Bachmann AM, O'Prey M, Kania E, Gonzalez PS, Macintosh R, Lao LY, Nixon C, Lopez J, Long JS, Tait SWG, Ryan KM. Mol Cell. 2019 Oct 3;76(1):163-176.e8. doi: 10.1016/j.molcel.2019.07.021. Epub 2019 Sep 3. PubMed |
| SOX11 and SOX4 drive the reactivation of an embryonic gene program during murine wound repair. Miao Q, Hill MC, Chen F, Mo Q, Ku AT, Ramos C, Sock E, Lefebvre V, Nguyen H. Nat Commun. 2019 Sep 6;10(1):4042. doi: 10.1038/s41467-019-11880-9. PubMed |
| CYP1B1 prevents proteasome-mediated XIAP degradation by inducing PKCepsilon activation and phosphorylation of XIAP. Baek HS, Kwon YJ, Ye DJ, Cho E, Kwon TU, Chun YJ. Biochim Biophys Acta Mol Cell Res. 2019 Dec;1866(12):118553. doi: 10.1016/j.bbamcr.2019.118553. Epub 2019 Sep 4. PubMed |
| Downregulation of SIRT2 by Chronic Stress Reduces Expression of Synaptic Plasticity-related Genes through the Upregulation of Ehmt2. Wang SE, Ko SY, Jo S, Jo HR, Han J, Kim YS, Son H. Exp Neurobiol. 2019 Aug 31;28(4):537-546. doi: 10.5607/en.2019.28.4.537. PubMed |
| Generation of Knockout Human Primary Keratinocytes by CRISPR/Cas9. Grossi S, Fenini G, Hennig P, Di Filippo M, Beer HD. Methods Mol Biol. 2019 Sep 10. doi: 10.1007/7651_2019_262. PubMed |
Generating Single Cell-Derived Knockout Clones in Mammalian Cells with CRISPR/Cas9.
Giuliano CJ, Lin A, Girish V, Sheltzer JM.
Curr Protoc Mol Biol. 2019 Sep;128(1):e100. doi: 10.1002/cpmb.100.
PubMed
Associated Plasmids |
| Microglial Pro-Inflammatory and Anti-Inflammatory Phenotypes Are Modulated by Translocator Protein Activation. Pozzo ED, Tremolanti C, Costa B, Giacomelli C, Milenkovic VM, Bader S, Wetzel CH, Rupprecht R, Taliani S, Settimo FD, Martini C. Int J Mol Sci. 2019 Sep 10;20(18). pii: ijms20184467. doi: 10.3390/ijms20184467. PubMed |
| DDX3X acts as a live-or-die checkpoint in stressed cells by regulating NLRP3 inflammasome. Samir P, Kesavardhana S, Patmore DM, Gingras S, Malireddi RKS, Karki R, Guy CS, Briard B, Place DE, Bhattacharya A, Sharma BR, Nourse A, King SV, Pitre A, Burton AR, Pelletier S, Gilbertson RJ, Kanneganti TD. Nature. 2019 Sep;573(7775):590-594. doi: 10.1038/s41586-019-1551-2. Epub 2019 Sep 11. PubMed |
| The Nuclear Matrix Protein SAFA Surveils Viral RNA and Facilitates Immunity by Activating Antiviral Enhancers and Super-enhancers. Cao L, Liu S, Li Y, Yang G, Luo Y, Li S, Du H, Zhao Y, Wang D, Chen J, Zhang Z, Li M, Ouyang S, Gao X, Sun Y, Wang Z, Yang L, Lin R, Wang P, You F. Cell Host Microbe. 2019 Sep 11;26(3):369-384.e8. doi: 10.1016/j.chom.2019.08.010. PubMed |
| RhTyrRS (Y341A), a novel human tyrosyl-tRNA synthetase mutant, stimulates thrombopoiesis through activation of the VEGF-R II/NF-kappaB pathway. Shi Y, Yu J, Zhang Y, Zhao B, Li Y, Ye Y, Yu Q, Yu M, Mo W, Gu J. Biochem Pharmacol. 2019 Nov;169:113634. doi: 10.1016/j.bcp.2019.113634. Epub 2019 Sep 9. PubMed |
| Genetic heterogeneity within collective invasion packs drives leader and follower cell phenotypes. Zoeller EL, Pedro B, Konen J, Dwivedi B, Rupji M, Sundararaman N, Wang L, Horton JR, Zhong C, Barwick BG, Cheng X, Martinez ED, Torres MP, Kowalski J, Marcus AI, Vertino PM. J Cell Sci. 2019 Oct 9;132(19). pii: jcs.231514. doi: 10.1242/jcs.231514. PubMed |
| The IL-6 signaling complex is a critical driver, negative prognostic factor, and therapeutic target in diffuse large B-cell lymphoma. Hashwah H, Bertram K, Stirm K, Stelling A, Wu CT, Kasser S, Manz MG, Theocharides AP, Tzankov A, Muller A. EMBO Mol Med. 2019 Oct;11(10):e10576. doi: 10.15252/emmm.201910576. Epub 2019 Sep 12. PubMed |
| Iron chelation and 2-oxoglutarate-dependent dioxygenase inhibition suppress mantle cell lymphoma's cyclin D1. Babosova O, Kapralova K, Raskova Kafkova L, Korinek V, Divoky V, Prchal JT, Lanikova L. J Cell Mol Med. 2019 Nov;23(11):7785-7795. doi: 10.1111/jcmm.14655. Epub 2019 Sep 13. PubMed |
| Circadian gene PER1 senses progesterone signal during human endometrial decidualization. Zhang Y, Meng N, Bao H, Jiang Y, Yang N, Wu K, Wu J, Wang H, Kong S, Zhang Y. J Endocrinol. 2019 Sep 1. pii: JOE-19-0284.R2. doi: 10.1530/JOE-19-0284. PubMed |
| The human cytomegalovirus-encoded G protein-coupled receptor UL33 exhibits oncomodulatory properties. van Senten JR, Bebelman MP, Fan TS, Heukers R, Bergkamp ND, van Gasselt P, Langemeijer EV, Slinger E, Lagerweij T, Rahbar A, Stigter-van Walsum M, Maussang D, Leurs R, Musters RJP, van Dongen GAMS, Soderberg-Naucler C, Wurdinger T, Siderius M, Smit MJ. J Biol Chem. 2019 Nov 1;294(44):16297-16308. doi: 10.1074/jbc.RA119.007796. Epub 2019 Sep 13. PubMed |
| Genomic tagging of endogenous human ESCRT-I complex preserves ESCRT-mediated membrane-remodeling functions. Hoffman HK, Fernandez MV, Groves NS, Freed EO, van Engelenburg SB. J Biol Chem. 2019 Nov 1;294(44):16266-16281. doi: 10.1074/jbc.RA119.009372. Epub 2019 Sep 13. PubMed |
| Intraneuronal Tau Misfolding Induced by Extracellular Amyloid-beta Oligomers. Rudenko LK, Wallrabe H, Periasamy A, Siller KH, Svindrych Z, Seward ME, Best MN, Bloom GS. J Alzheimers Dis. 2019;71(4):1125-1138. doi: 10.3233/JAD-190226. PubMed |
| TRP14 promotes resistance to cisplatin by inducing autophagy in ovarian cancer. Tan WX, Xu TM, Zhou ZL, Lv XJ, Liu J, Zhang WJ, Cui MH. Oncol Rep. 2019 Aug 2. doi: 10.3892/or.2019.7258. PubMed |
| MCC950/CRID3 potently targets the NACHT domain of wild-type NLRP3 but not disease-associated mutants for inflammasome inhibition. Vande Walle L, Stowe IB, Sacha P, Lee BL, Demon D, Fossoul A, Van Hauwermeiren F, Saavedra PHV, Simon P, Subrt V, Kostka L, Stivala CE, Pham VC, Staben ST, Yamazoe S, Konvalinka J, Kayagaki N, Lamkanfi M. PLoS Biol. 2019 Sep 16;17(9):e3000354. doi: 10.1371/journal.pbio.3000354. eCollection 2019 Sep. PubMed |
| Progenitor-derived human endothelial cells evade alloimmunity by CRISPR/Cas9-mediated complete ablation of MHC expression. Merola J, Reschke M, Pierce RW, Qin L, Spindler S, Baltazar T, Manes TD, Lopez-Giraldez F, Li G, Bracaglia LG, Xie C, Kirkiles-Smith N, Saltzman WM, Tietjen GT, Tellides G, Pober JS. JCI Insight. 2019 Oct 17;4(20). pii: 129739. doi: 10.1172/jci.insight.129739. PubMed |
| Flow cytometry-based FRET identifies binding intensities in PPARgamma1 protein-protein interactions in living cells. Trumper V, von Knethen A, Preuss A, Ermilov E, Hackbarth S, Kuchler L, Gunne S, Schafer A, Bornhutter T, Vereb G, Ujlaky-Nagy L, Brune B, Roder B, Schindler M, Parnham MJ, Knape T. Theranostics. 2019 Jul 28;9(19):5444-5463. doi: 10.7150/thno.29367. eCollection 2019. PubMed |
| Mitochondrial protein import is regulated by p17/PERMIT to mediate lipid metabolism and cellular stress. Oleinik N, Kim J, Roth BM, Selvam SP, Gooz M, Johnson RH, Lemasters JJ, Ogretmen B. Sci Adv. 2019 Sep 11;5(9):eaax1978. doi: 10.1126/sciadv.aax1978. eCollection 2019 Sep. PubMed |
| Mitochondrial PE potentiates respiratory enzymes to amplify skeletal muscle aerobic capacity. Heden TD, Johnson JM, Ferrara PJ, Eshima H, Verkerke ARP, Wentzler EJ, Siripoksup P, Narowski TM, Coleman CB, Lin CT, Ryan TE, Reidy PT, de Castro Bras LE, Karner CM, Burant CF, Maschek JA, Cox JE, Mashek DG, Kardon G, Boudina S, Zeczycki TN, Rutter J, Shaikh SR, Vance JE, Drummond MJ, Neufer PD, Funai K. Sci Adv. 2019 Sep 11;5(9):eaax8352. doi: 10.1126/sciadv.aax8352. eCollection 2019 Sep. PubMed |
| Genetic determinants of cellular addiction to DNA polymerase theta. Feng W, Simpson DA, Carvajal-Garcia J, Price BA, Kumar RJ, Mose LE, Wood RD, Rashid N, Purvis JE, Parker JS, Ramsden DA, Gupta GP. Nat Commun. 2019 Sep 19;10(1):4286. doi: 10.1038/s41467-019-12234-1. PubMed |
| Ran pathway-independent regulation of mitotic Golgi disassembly by Importin-alpha. Chang CC, Chen CJ, Grauffel C, Pien YC, Lim C, Tsai SY, Hsia KC. Nat Commun. 2019 Sep 20;10(1):4307. doi: 10.1038/s41467-019-12207-4. PubMed |
| Tet inactivation disrupts YY1 binding and long-range chromatin interactions during embryonic heart development. Fang S, Li J, Xiao Y, Lee M, Guo L, Han W, Li T, Hill MC, Hong T, Mo W, Xu R, Zhang P, Wang F, Chang J, Zhou Y, Sun D, Martin JF, Huang Y. Nat Commun. 2019 Sep 20;10(1):4297. doi: 10.1038/s41467-019-12325-z. PubMed |
| Mitochondrial Reprogramming Underlies Resistance to BCL-2 Inhibition in Lymphoid Malignancies. Guieze R, Liu VM, Rosebrock D, Jourdain AA, Hernandez-Sanchez M, Martinez Zurita A, Sun J, Ten Hacken E, Baranowski K, Thompson PA, Heo JM, Cartun Z, Aygun O, Iorgulescu JB, Zhang W, Notarangelo G, Livitz D, Li S, Davids MS, Biran A, Fernandes SM, Brown JR, Lako A, Ciantra ZB, Lawlor MA, Keskin DB, Udeshi ND, Wierda WG, Livak KJ, Letai AG, Neuberg D, Harper JW, Carr SA, Piccioni F, Ott CJ, Leshchiner I, Johannessen CM, Doench J, Mootha VK, Getz G, Wu CJ. Cancer Cell. 2019 Oct 14;36(4):369-384.e13. doi: 10.1016/j.ccell.2019.08.005. Epub 2019 Sep 19. PubMed |
| Pooled CRISPR-Based Genetic Screens in Mammalian Cells. Chan K, Tong AHY, Brown KR, Mero P, Moffat J. J Vis Exp. 2019 Sep 4;(151). doi: 10.3791/59780. PubMed |
| Cytokine Effects on the Entry of Filovirus Envelope Pseudotyped Virus-Like Particles into Primary Human Macrophages. Stantchev TS, Zack-Taylor A, Mattson N, Strebel K, Broder CC, Clouse KA. Viruses. 2019 Sep 23;11(10). pii: v11100889. doi: 10.3390/v11100889. PubMed |
| Blockade of Glutathione Metabolism in IDH1-Mutated Glioma. Tang X, Fu X, Liu Y, Yu D, Cai SJ, Yang C. Mol Cancer Ther. 2020 Jan;19(1):221-230. doi: 10.1158/1535-7163.MCT-19-0103. Epub 2019 Sep 23. PubMed |
| Ehrlichia chaffeensis Outer Membrane Protein 1-Specific Human Antibody-Mediated Immunity Is Defined by Intracellular TRIM21-Dependent Innate Immune Activation and Extracellular Neutralization. Velayutham TS, Kumar S, Zhang X, Kose N, Walker DH, Winslow G, Crowe JE Jr, McBride JW. Infect Immun. 2019 Nov 18;87(12). pii: IAI.00383-19. doi: 10.1128/IAI.00383-19. Print 2019 Dec. PubMed |
| High-throughput genome-wide phenotypic screening via immunomagnetic cell sorting. Mair B, Aldridge PM, Atwal RS, Philpott D, Zhang M, Masud SN, Labib M, Tong AHY, Sargent EH, Angers S, Moffat J, Kelley SO. Nat Biomed Eng. 2019 Oct;3(10):796-805. doi: 10.1038/s41551-019-0454-8. Epub 2019 Sep 23. PubMed |
ER-lysosome contacts enable cholesterol sensing by mTORC1 and drive aberrant growth signalling in Niemann-Pick type C.
Lim CY, Davis OB, Shin HR, Zhang J, Berdan CA, Jiang X, Counihan JL, Ory DS, Nomura DK, Zoncu R.
Nat Cell Biol. 2019 Oct;21(10):1206-1218. doi: 10.1038/s41556-019-0391-5. Epub 2019 Sep 23.
PubMed
Associated Plasmids |
| Genome-wide screening identifies novel genes implicated in cellular sensitivity to BRAF(V600E) expression. Ko T, Sharma R, Li S. Oncogene. 2020 Jan;39(4):723-738. doi: 10.1038/s41388-019-1022-0. Epub 2019 Sep 23. PubMed |
| T-Box20 inhibits osteogenic differentiation in adipose-derived human mesenchymal stem cells: the role of T-Box20 on osteogenesis. Mollazadeh S, Fazly Bazzaz BS, Neshati V, de Vries AAF, Naderi-Meshkin H, Mojarad M, Neshati Z, Kerachian MA. J Biol Res (Thessalon). 2019 Sep 18;26:8. doi: 10.1186/s40709-019-0099-5. eCollection 2019 Dec. PubMed |
| A genome-wide CRISPR screen identifies FBXO42 involvement in resistance toward MEK inhibition in NRAS-mutant melanoma. Nagler A, Vredevoogd DW, Alon M, Cheng PF, Trabish S, Kalaora S, Arafeh R, Goldin V, Levesque MP, Peeper DS, Samuels Y. Pigment Cell Melanoma Res. 2020 Mar;33(2):334-344. doi: 10.1111/pcmr.12825. Epub 2019 Oct 10. PubMed |
| Genome-Wide CRISPR-Cas9 Screen Reveals Selective Vulnerability of ATRX-Mutant Cancers to WEE1 Inhibition. Liang J, Zhao H, Diplas BH, Liu S, Liu J, Wang D, Lu Y, Zhu Q, Wu J, Wang W, Yan H, Zeng YX, Wang X, Jiao Y. Cancer Res. 2020 Feb 1;80(3):510-523. doi: 10.1158/0008-5472.CAN-18-3374. Epub 2019 Sep 24. PubMed |
| BH3-only proteins target BCL-xL/MCL-1, not BAX/BAK, to initiate apoptosis. Huang K, O'Neill KL, Li J, Zhou W, Han N, Pang X, Wu W, Struble L, Borgstahl G, Liu Z, Zhang L, Luo X. Cell Res. 2019 Nov;29(11):942-952. doi: 10.1038/s41422-019-0231-y. Epub 2019 Sep 24. PubMed |
| Control over single-cell distribution of G1 lengths by WNT governs pluripotency. Jang J, Han D, Golkaram M, Audouard M, Liu G, Bridges D, Hellander S, Chialastri A, Dey SS, Petzold LR, Kosik KS. PLoS Biol. 2019 Sep 26;17(9):e3000453. doi: 10.1371/journal.pbio.3000453. eCollection 2019 Sep. PubMed |
| Protein phosphatase 2A controls ongoing DNA replication by binding to and regulating cell division cycle 45 (CDC45). Perl AL, O'Connor CM, Fa P, Mayca Pozo F, Zhang J, Zhang Y, Narla G. J Biol Chem. 2019 Nov 8;294(45):17043-17059. doi: 10.1074/jbc.RA119.010432. Epub 2019 Sep 27. PubMed |
| PRDM16 Maintains Homeostasis of the Intestinal Epithelium by Controlling Region-Specific Metabolism. Stine RR, Sakers AP, TeSlaa T, Kissig M, Stine ZE, Kwon CW, Cheng L, Lim HW, Kaestner KH, Rabinowitz JD, Seale P. Cell Stem Cell. 2019 Dec 5;25(6):830-845.e8. doi: 10.1016/j.stem.2019.08.017. Epub 2019 Sep 26. PubMed |
| Dynamic Incorporation of Histone H3 Variants into Chromatin Is Essential for Acquisition of Aggressive Traits and Metastatic Colonization. Gomes AP, Ilter D, Low V, Rosenzweig A, Shen ZJ, Schild T, Rivas MA, Er EE, McNally DR, Mutvei AP, Han J, Ou YH, Cavaliere P, Mullarky E, Nagiec M, Shin S, Yoon SO, Dephoure N, Massague J, Melnick AM, Cantley LC, Tyler JK, Blenis J. Cancer Cell. 2019 Oct 14;36(4):402-417.e13. doi: 10.1016/j.ccell.2019.08.006. Epub 2019 Sep 26. PubMed |
HIF-independent synthetic lethality between CDK4/6 inhibition and VHL loss across species.
Nicholson HE, Tariq Z, Housden BE, Jennings RB, Stransky LA, Perrimon N, Signoretti S, Kaelin WG Jr.
Sci Signal. 2019 Oct 1;12(601). pii: 12/601/eaay0482. doi: 10.1126/scisignal.aay0482.
PubMed
Associated Plasmids |
| A PINCH-1-Smurf1 signaling axis mediates mechano-regulation of BMPR2 and stem cell differentiation. Guo L, Wang R, Zhang K, Yuan J, Wang J, Wang X, Ma J, Wu C. J Cell Biol. 2019 Nov 4;218(11):3773-3794. doi: 10.1083/jcb.201902022. Epub 2019 Oct 2. PubMed |
Conserved CxnC motifs in Kaposi's sarcoma-associated herpesvirus ORF66 are required for viral late gene expression and are essential for its interaction with ORF34.
Didychuk AL, Castaneda AF, Kushnir LO, Huang CJ, Glaunsinger BA.
J Virol. 2019 Oct 2. pii: JVI.01299-19. doi: 10.1128/JVI.01299-19.
PubMed
Associated Plasmids |
| SEMA4C is a novel target to limit osteosarcoma growth, progression, and metastasis. Smeester BA, Slipek NJ, Pomeroy EJ, Bomberger HE, Shamsan GA, Peterson JJ, Crosby MR, Draper GM, Becklin KL, Rahrmann EP, McCarthy JB, Odde DJ, Wood DK, Largaespada DA, Moriarity BS. Oncogene. 2020 Jan;39(5):1049-1062. doi: 10.1038/s41388-019-1041-x. Epub 2019 Oct 3. PubMed |
| Essential role of glucokinase in the protection of pancreatic beta cells to the glucose energetic status. Marques P, Kamitz A, Bartolome A, Burillo J, Martinez H, Jimenez B, Fernandez-Rhodes M, Guillen C, Benito M. Cell Death Discov. 2019 Sep 30;5:138. doi: 10.1038/s41420-019-0219-x. eCollection 2019. PubMed |
| Stimulation of Piezo1 by mechanical signals promotes bone anabolism. Li X, Han L, Nookaew I, Mannen E, Silva MJ, Almeida M, Xiong J. Elife. 2019 Oct 7;8. pii: 49631. doi: 10.7554/eLife.49631. PubMed |
| Live Cell Imaging to Assess the Dynamics of Metaphase Timing and Cell Fate Following Mitotic Spindle Perturbations. Mercadante DL, Crowley EA, Manning AL. J Vis Exp. 2019 Sep 20;(151). doi: 10.3791/60255. PubMed |
Pyrin dephosphorylation is sufficient to trigger inflammasome activation in familial Mediterranean fever patients.
Magnotti F, Lefeuvre L, Benezech S, Malsot T, Waeckel L, Martin A, Kerever S, Chirita D, Desjonqueres M, Duquesne A, Gerfaud-Valentin M, Laurent A, Seve P, Popoff MR, Walzer T, Belot A, Jamilloux Y, Henry T.
EMBO Mol Med. 2019 Oct 7:e10547. doi: 10.15252/emmm.201910547.
PubMed
Associated Plasmids |
| L-type voltage-gated Ca(2+) channel CaV1.2 regulates chondrogenesis during limb development. Atsuta Y, Tomizawa RR, Levin M, Tabin CJ. Proc Natl Acad Sci U S A. 2019 Oct 22;116(43):21592-21601. doi: 10.1073/pnas.1908981116. Epub 2019 Oct 7. PubMed |
Mechanosensing during directed cell migration requires dynamic actin polymerization at focal adhesions.
Puleo JI, Parker SS, Roman MR, Watson AW, Eliato KR, Peng L, Saboda K, Roe DJ, Ros R, Gertler FB, Mouneimne G.
J Cell Biol. 2019 Oct 8. pii: jcb.201902101. doi: 10.1083/jcb.201902101.
PubMed
Associated Plasmids |
| Reduction of Global H3K27me(3) Enhances HER2/ErbB2 Targeted Therapy. Hirukawa A, Singh S, Wang J, Rennhack JP, Swiatnicki M, Sanguin-Gendreau V, Zuo D, Daldoul K, Lavoie C, Park M, Andrechek ER, Westbrook TF, Harris LN, Varadan V, Smith HW, Muller WJ. Cell Rep. 2019 Oct 8;29(2):249-257.e8. doi: 10.1016/j.celrep.2019.08.105. PubMed |
| Shank Proteins Couple the Endocytic Zone to the Postsynaptic Density to Control Trafficking and Signaling of Metabotropic Glutamate Receptor 5. Scheefhals N, Catsburg LAE, Westerveld ML, Blanpied TA, Hoogenraad CC, MacGillavry HD. Cell Rep. 2019 Oct 8;29(2):258-269.e8. doi: 10.1016/j.celrep.2019.08.102. PubMed |
| Chronic intermittent tachypacing by an optogenetic approach induces arrhythmia vulnerability in human engineered heart tissue. Lemme M, Braren I, Prondzynski M, Aksehirlioglu B, Ulmer BM, Schulze ML, Ismaili D, Meyer C, Hansen A, Christ T, Lemoine MD, Eschenhagen T. Cardiovasc Res. 2019 Oct 9. pii: 5584236. doi: 10.1093/cvr/cvz245. PubMed |
| Specific interactions of BCL-2 family proteins mediate sensitivity to BH3-mimetics in diffuse large B-cell lymphoma. Smith VM, Dietz A, Henz K, Bruecher D, Jackson R, Kowald L, van Wijk SJL, Jayne S, Macip S, Fulda S, Dyer MJS, Vogler M. Haematologica. 2019 Oct 10. pii: haematol.2019.220525. doi: 10.3324/haematol.2019.220525. PubMed |
| Therapeutic preferability of gemcitabine for ARID1A-deficient ovarian clear cell carcinoma. Kuroda T, Ogiwara H, Sasaki M, Takahashi K, Yoshida H, Kiyokawa T, Sudo K, Tamura K, Kato T, Okamoto A, Kohno T. Gynecol Oncol. 2019 Dec;155(3):489-498. doi: 10.1016/j.ygyno.2019.10.002. Epub 2019 Oct 8. PubMed |
| TFPa/HADHA is required for fatty acid beta-oxidation and cardiolipin re-modeling in human cardiomyocytes. Miklas JW, Clark E, Levy S, Detraux D, Leonard A, Beussman K, Showalter MR, Smith AT, Hofsteen P, Yang X, Macadangdang J, Manninen T, Raftery D, Madan A, Suomalainen A, Kim DH, Murry CE, Fiehn O, Sniadecki NJ, Wang Y, Ruohola-Baker H. Nat Commun. 2019 Oct 11;10(1):4671. doi: 10.1038/s41467-019-12482-1. PubMed |
| Profilin-Mediated Actin Allocation Regulates the Growth of Epithelial Microvilli. Faust JJ, Millis BA, Tyska MJ. Curr Biol. 2019 Oct 21;29(20):3457-3465.e3. doi: 10.1016/j.cub.2019.08.051. Epub 2019 Oct 10. PubMed |
| Tumor-expressed B7-H3 mediates the inhibition of antitumor T-cell functions in ovarian cancer insensitive to PD-1 blockade therapy. Cai D, Li J, Liu D, Hong S, Qiao Q, Sun Q, Li P, Lyu N, Sun T, Xie S, Guo L, Ni L, Jin L, Dong C. Cell Mol Immunol. 2019 Oct 14. pii: 10.1038/s41423-019-0305-2. doi: 10.1038/s41423-019-0305-2. PubMed |
| Carboxypeptidase A6 Promotes the Proliferation and Migration of Hepatocellular Carcinoma by Up-regulating AKT Signaling Pathway. Huang QB, Zhang HW, Liao ZB. Curr Med Sci. 2019 Oct;39(5):727-733. doi: 10.1007/s11596-019-2098-z. Epub 2019 Oct 14. PubMed |
| The ADP/ATP translocase drives mitophagy independent of nucleotide exchange. Hoshino A, Wang WJ, Wada S, McDermott-Roe C, Evans CS, Gosis B, Morley MP, Rathi KS, Li J, Li K, Yang S, McManus MJ, Bowman C, Potluri P, Levin M, Damrauer S, Wallace DC, Holzbaur ELF, Arany Z. Nature. 2019 Nov;575(7782):375-379. doi: 10.1038/s41586-019-1667-4. Epub 2019 Oct 16. PubMed |
| Inhibition of histone deacetylase 2 reduces MDM2 expression and reduces tumor growth in dedifferentiated liposarcoma. Seligson ND, Stets CW, Demoret BW, Awasthi A, Grosenbacher N, Shakya R, Hays JL, Chen JL. Oncotarget. 2019 Oct 1;10(55):5671-5679. doi: 10.18632/oncotarget.27144. eCollection 2019 Oct 1. PubMed |
| CircPLEKHM3 acts as a tumor suppressor through regulation of the miR-9/BRCA1/DNAJB6/KLF4/AKT1 axis in ovarian cancer. Zhang L, Zhou Q, Qiu Q, Hou L, Wu M, Li J, Li X, Lu B, Cheng X, Liu P, Lu W, Lu Y. Mol Cancer. 2019 Oct 17;18(1):144. doi: 10.1186/s12943-019-1080-5. PubMed |
| Direct RNA sequencing enables m(6)A detection in endogenous transcript isoforms at base-specific resolution. Lorenz DA, Sathe S, Einstein JM, Yeo GW. RNA. 2020 Jan;26(1):19-28. doi: 10.1261/rna.072785.119. Epub 2019 Oct 17. PubMed |
| The tumor suppressor TMEM127 regulates insulin sensitivity in a tissue-specific manner. Srikantan S, Deng Y, Cheng ZM, Luo A, Qin Y, Gao Q, Sande-Docor GM, Tao S, Zhang X, Harper N, Shannon CE, Fourcaudot M, Li Z, Kasinath BS, Harrison S, Ahuja S, Reddick RL, Dong LQ, Abdul-Ghani M, Norton L, Aguiar RCT, Dahia PLM. Nat Commun. 2019 Oct 17;10(1):4720. doi: 10.1038/s41467-019-12661-0. PubMed |
| KLF8 overexpression promotes the growth of human lung cancer cells by promoting the expression of JMJD2A. Ma D, Liu H, Qin Y, Tian Z, Li S, Liang N. Cancer Cell Int. 2019 Oct 7;19:258. doi: 10.1186/s12935-019-0970-3. eCollection 2019. PubMed |
| Mammalian Surface Display Screening of Diverse Cystine-Dense Peptide Libraries for Difficult-to-Drug Targets. Crook ZR, Sevilla GP, Mhyre AJ, Olson JM. Methods Mol Biol. 2020;2070:363-396. doi: 10.1007/978-1-4939-9853-1_21. PubMed |
| MIGA2 Links Mitochondria, the ER, and Lipid Droplets and Promotes De Novo Lipogenesis in Adipocytes. Freyre CAC, Rauher PC, Ejsing CS, Klemm RW. Mol Cell. 2019 Dec 5;76(5):811-825.e14. doi: 10.1016/j.molcel.2019.09.011. Epub 2019 Oct 15. PubMed |
| ATG5 cancer mutations and alternative mRNA splicing reveal a conjugation switch that regulates ATG12-ATG5-ATG16L1 complex assembly and autophagy. Wible DJ, Chao HP, Tang DG, Bratton SB. Cell Discov. 2019 Aug 27;5:42. doi: 10.1038/s41421-019-0110-1. eCollection 2019. PubMed |
| MALT1 Phosphorylation Controls Activation of T Lymphocytes and Survival of ABC-DLBCL Tumor Cells. Gehring T, Erdmann T, Rahm M, Grass C, Flatley A, O'Neill TJ, Woods S, Meininger I, Karayel O, Kutzner K, Grau M, Shinohara H, Lammens K, Feederle R, Hauck SM, Lenz G, Krappmann D. Cell Rep. 2019 Oct 22;29(4):873-888.e10. doi: 10.1016/j.celrep.2019.09.040. PubMed |
| Exosome-Mediated MiR-155 Transfer Contributes to Hepatocellular Carcinoma Cell Proliferation by Targeting PTEN. Sun JF, Zhang D, Gao CJ, Zhang YW, Dai QS. Med Sci Monit Basic Res. 2019 Oct 24;25:218-228. doi: 10.12659/MSMBR.918134. PubMed |
| Heterogeneity in old fibroblasts is linked to variability in reprogramming and wound healing. Mahmoudi S, Mancini E, Xu L, Moore A, Jahanbani F, Hebestreit K, Srinivasan R, Li X, Devarajan K, Prelot L, Ang CE, Shibuya Y, Benayoun BA, Chang ALS, Wernig M, Wysocka J, Longaker MT, Snyder MP, Brunet A. Nature. 2019 Oct;574(7779):553-558. doi: 10.1038/s41586-019-1658-5. Epub 2019 Oct 23. PubMed |
| Japanese Encephalitis Virus infection induces inflammation of swine testis through RIG-I-NF-kB signaling pathway. Zheng B, Wang X, Liu Y, Li Y, Long S, Gu C, Ye J, Xie S, Cao S. Vet Microbiol. 2019 Nov;238:108430. doi: 10.1016/j.vetmic.2019.108430. Epub 2019 Sep 28. PubMed |
| Circular RNA circPICALM sponges miR-1265 to inhibit bladder cancer metastasis and influence FAK phosphorylation. Yan D, Dong W, He Q, Yang M, Huang L, Kong J, Qin H, Lin T, Huang J. EBioMedicine. 2019 Oct;48:316-331. doi: 10.1016/j.ebiom.2019.08.074. Epub 2019 Oct 21. PubMed |
| Genes essential for embryonic stem cells are associated with neurodevelopmental disorders. Shohat S, Shifman S. Genome Res. 2019 Nov;29(11):1910-1918. doi: 10.1101/gr.250019.119. Epub 2019 Oct 24. PubMed |
Fate-mapping post-hypoxic tumor cells reveals a ROS-resistant phenotype that promotes metastasis.
Godet I, Shin YJ, Ju JA, Ye IC, Wang G, Gilkes DM.
Nat Commun. 2019 Oct 24;10(1):4862. doi: 10.1038/s41467-019-12412-1.
PubMed
Associated Plasmids |
| STING Restricts oHSV Replication and Spread in Resistant MPNSTs but Is Dispensable for Basal IFN-Stimulated Gene Upregulation. Lee JM, Ghonime MG, Cassady KA. Mol Ther Oncolytics. 2019 Sep 16;15:91-100. doi: 10.1016/j.omto.2019.09.001. eCollection 2019 Dec 20. PubMed |
| Phase separation-deficient TDP43 Schmidt. Nat Commun. 2019 PubMed |
| Pyridoxamine-phosphate oxidases and pyridoxamine-phosphate oxidase-related proteins catalyze the oxidation of 6-NAD(P)H to NAD(P). Marbaix AY, Chehade G, Noel G, Morsomme P, Vertommen D, Bommer GT, Van Schaftingen E. Biochem J. 2019 Oct 30;476(20):3033-3052. doi: 10.1042/BCJ20190602. PubMed |
| Promoter demethylation of the asparagine synthetase gene is required for ATF4-dependent adaptation to asparagine depletion. Jiang J, Srivastava S, Seim G, Pavlova NN, King B, Zou L, Zhang C, Zhong M, Feng H, Kapur R, Wek RC, Fan J, Zhang J. J Biol Chem. 2019 Dec 6;294(49):18674-18684. doi: 10.1074/jbc.RA119.010447. Epub 2019 Oct 28. PubMed |
| Nucleus pulposus primary cilia alter their length in response to changes in extracellular osmolarity but do not control TonEBP-mediated osmoregulation. Choi H, Madhu V, Shapiro IM, Risbud MV. Sci Rep. 2019 Oct 29;9(1):15469. doi: 10.1038/s41598-019-51939-7. PubMed |
| CRISPR-Cas9-mediated knockout of SPRY2 in human hepatocytes leads to increased glucose uptake and lipid droplet accumulation. Cook NL, Pjanic M, Emmerich AG, Rao AS, Hetty S, Knowles JW, Quertermous T, Castillejo-Lopez C, Ingelsson E. BMC Endocr Disord. 2019 Oct 29;19(1):115. doi: 10.1186/s12902-019-0442-8. PubMed |
| Postmortem Cortex Samples Identify Distinct Molecular Subtypes of ALS: Retrotransposon Activation, Oxidative Stress, and Activated Glia. Tam OH, Rozhkov NV, Shaw R, Kim D, Hubbard I, Fennessey S, Propp N, Fagegaltier D, Harris BT, Ostrow LW, Phatnani H, Ravits J, Dubnau J, Gale Hammell M. Cell Rep. 2019 Oct 29;29(5):1164-1177.e5. doi: 10.1016/j.celrep.2019.09.066. PubMed |
| USP7-Dependent Regulation of TRAF Activation and Signaling by a Viral Interferon Regulatory Factor Homologue. Xiang Q, Ju H, Nicholas J. J Virol. 2020 Jan 6;94(2). pii: JVI.01553-19. doi: 10.1128/JVI.01553-19. Print 2020 Jan 6. PubMed |
| N-WASP Control of LPAR1 Trafficking Establishes Response to Self-Generated LPA Gradients to Promote Pancreatic Cancer Cell Metastasis. Juin A, Spence HJ, Martin KJ, McGhee E, Neilson M, Cutiongco MFA, Gadegaard N, Mackay G, Fort L, Lilla S, Kalna G, Thomason P, Koh YWH, Norman JC, Insall RH, Machesky LM. Dev Cell. 2019 Nov 18;51(4):431-445.e7. doi: 10.1016/j.devcel.2019.09.018. Epub 2019 Oct 24. PubMed |
| Environmental enrichment prevents Abeta oligomer-induced synaptic dysfunction through mirna-132 and hdac3 signaling pathways. Wei Z, Meng X, El Fatimy R, Sun B, Mai D, Zhang J, Arora R, Zeng A, Xu P, Qu S, Krichevsky AM, Selkoe DJ, Li S. Neurobiol Dis. 2020 Feb;134:104617. doi: 10.1016/j.nbd.2019.104617. Epub 2019 Oct 24. PubMed |
| A missense mutation in SNRPE linked to non-syndromal microcephaly interferes with U snRNP assembly and pre-mRNA splicing. Chen T, Zhang B, Ziegenhals T, Prusty AB, Frohler S, Grimm C, Hu Y, Schaefke B, Fang L, Zhang M, Kraemer N, Kaindl AM, Fischer U, Chen W. PLoS Genet. 2019 Oct 31;15(10):e1008460. doi: 10.1371/journal.pgen.1008460. eCollection 2019 Oct. PubMed |
| Modulation of Calretinin Expression in Human Mesothelioma Cells Reveals the Implication of the FAK and Wnt Signaling Pathways in Conferring Chemoresistance towards Cisplatin. Worthmuller J, Salicio V, Oberson A, Blum W, Schwaller B. Int J Mol Sci. 2019 Oct 29;20(21). pii: ijms20215391. doi: 10.3390/ijms20215391. PubMed |
Oct4-mediated reprogramming induces embryonic-like microRNA expression signatures in human fibroblasts.
Peskova L, Cerna K, Oppelt J, Mraz M, Barta T.
Sci Rep. 2019 Oct 31;9(1):15759. doi: 10.1038/s41598-019-52294-3.
PubMed
Associated Plasmids |
| Sustained Egr-1 Response via p38 MAP Kinase Signaling Modulates Early Immune Responses of Dendritic Cells Parasitized by Toxoplasma gondii. Ten Hoeve AL, Hakimi MA, Barragan A. Front Cell Infect Microbiol. 2019 Oct 11;9:349. doi: 10.3389/fcimb.2019.00349. eCollection 2019. PubMed |
| mTOR and autophagy pathways are dysregulated in murine and human models of Schaaf-Yang syndrome. Crutcher E, Pal R, Naini F, Zhang P, Laugsch M, Kim J, Bajic A, Schaaf CP. Sci Rep. 2019 Nov 4;9(1):15935. doi: 10.1038/s41598-019-52287-2. PubMed |
Negative regulation of autophagy by UBA6-BIRC6-mediated ubiquitination of LC3.
Jia R, Bonifacino JS.
Elife. 2019 Nov 6;8. pii: 50034. doi: 10.7554/eLife.50034.
PubMed
Associated Plasmids |
| Aryl Sulfonamides Degrade RBM39 and RBM23 by Recruitment to CRL4-DCAF15. Ting TC, Goralski M, Klein K, Wang B, Kim J, Xie Y, Nijhawan D. Cell Rep. 2019 Nov 5;29(6):1499-1510.e6. doi: 10.1016/j.celrep.2019.09.079. PubMed |
| CRISPR Screening Identifies WEE1 as a Combination Target for Standard Chemotherapy in Malignant Pleural Mesothelioma. Xu D, Liang SQ, Yang H, Bruggmann R, Berezowska S, Yang Z, Marti TM, Hall SRR, Gao Y, Kocher GJ, Schmid RA, Peng RW. Mol Cancer Ther. 2020 Feb;19(2):661-672. doi: 10.1158/1535-7163.MCT-19-0724. Epub 2019 Nov 6. PubMed |
| Adaptive mutability of colorectal cancers in response to targeted therapies. Russo M, Crisafulli G, Sogari A, Reilly NM, Arena S, Lamba S, Bartolini A, Amodio V, Magri A, Novara L, Sarotto I, Nagel ZD, Piett CG, Amatu A, Sartore-Bianchi A, Siena S, Bertotti A, Trusolino L, Corigliano M, Gherardi M, Lagomarsino MC, Di Nicolantonio F, Bardelli A. Science. 2019 Dec 20;366(6472):1473-1480. doi: 10.1126/science.aav4474. Epub 2019 Nov 7. PubMed |
| Regulation of CHD2 expression by the Chaserr long noncoding RNA gene is essential for viability. Rom A, Melamed L, Gil N, Goldrich MJ, Kadir R, Golan M, Biton I, Perry RB, Ulitsky I. Nat Commun. 2019 Nov 8;10(1):5092. doi: 10.1038/s41467-019-13075-8. PubMed |
| Rab8 GTPase regulates Klotho-mediated inhibition of cell growth and progression by directly modulating its surface expression in human non-small cell lung cancer. Chen B, Huang S, Pisanic Ii TR, Stark A, Tao Y, Cheng B, Li Y, Wei Y, Zhao W, Wang TH, Wu J. EBioMedicine. 2019 Nov;49:118-132. doi: 10.1016/j.ebiom.2019.10.040. Epub 2019 Nov 6. PubMed |
| Production of Lentivirus for the Establishment of CAR-T Cells. Lana MG, Strauss BE. Methods Mol Biol. 2020;2086:61-67. doi: 10.1007/978-1-0716-0146-4_4. PubMed |
| Protein targeting chimeric molecules specific for dual bromodomain 4 (BRD4) and Polo-like kinase 1 (PLK1) proteins in acute myeloid leukemia cells. Mu X, Bai L, Xu Y, Wang J, Lu H. Biochem Biophys Res Commun. 2020 Jan 22;521(4):833-839. doi: 10.1016/j.bbrc.2019.11.007. Epub 2019 Nov 7. PubMed |
| Cell-Cycle Asynchrony Generates DNA Damage at Mitotic Entry in Polyploid Cells. Nano M, Gemble S, Simon A, Pennetier C, Fraisier V, Marthiens V, Basto R. Curr Biol. 2019 Nov 18;29(22):3937-3945.e7. doi: 10.1016/j.cub.2019.09.041. Epub 2019 Nov 7. PubMed |
| GLP-1 Receptor Activation Abrogates beta-Cell Dysfunction by PKA Calpha-Mediated Degradation of Thioredoxin Interacting Protein. He S, Wu W, Wan Y, Nandakumar KS, Cai X, Tang X, Liu S, Yao X. Front Pharmacol. 2019 Oct 25;10:1230. doi: 10.3389/fphar.2019.01230. eCollection 2019. PubMed |
| Collagen IV (COL4A1, COL4A2), a Component of the Viral Biofilm, Is Induced by the HTLV-1 Oncoprotein Tax and Impacts Virus Transmission. Millen S, Gross C, Donhauser N, Mann MC, Peloponese JM Jr, Thoma-Kress AK. Front Microbiol. 2019 Oct 23;10:2439. doi: 10.3389/fmicb.2019.02439. eCollection 2019. PubMed |
| JAK2 (V617F) -Mediated Clonal Hematopoiesis Accelerates Pathological Remodeling in Murine Heart Failure. Sano S, Wang Y, Yura Y, Sano M, Oshima K, Yang Y, Katanasaka Y, Min KD, Matsuura S, Ravid K, Mohi G, Walsh K. JACC Basic Transl Sci. 2019 Sep 18;4(6):684-697. doi: 10.1016/j.jacbts.2019.05.013. eCollection 2019 Oct. PubMed |
| Dose-dependent activation of gene expression is achieved using CRISPR and small molecules that recruit endogenous chromatin machinery. Chiarella AM, Butler KV, Gryder BE, Lu D, Wang TA, Yu X, Pomella S, Khan J, Jin J, Hathaway NA. Nat Biotechnol. 2020 Jan;38(1):50-55. doi: 10.1038/s41587-019-0296-7. Epub 2019 Nov 11. PubMed |
| IRG1 and Inducible Nitric Oxide Synthase Act Redundantly with Other Interferon-Gamma-Induced Factors To Restrict Intracellular Replication of Legionella pneumophila. Price JV, Russo D, Ji DX, Chavez RA, DiPeso L, Lee AY, Coers J, Vance RE. mBio. 2019 Nov 12;10(6). pii: mBio.02629-19. doi: 10.1128/mBio.02629-19. PubMed |
| Microparticle Depots for Controlled and Sustained Release of Endosomolytic Nanoparticles. Garland KM, Sevimli S, Kilchrist KV, Duvall CL, Cook RS, Wilson JT. Cell Mol Bioeng. 2019 May 3;12(5):429-442. doi: 10.1007/s12195-019-00571-6. eCollection 2019 Oct. PubMed |
| Transplantation of neural scaffolds consisting of dermal fibroblast-reprogrammed neurons and 3D silk fibrous materials promotes the repair of spinal cord injury. Hu Y, Zhang F, Zhong W, Liu Y, He Q, Yang M, Chen H, Xu X, Bian K, Xu J, Li J, Shen Y, Zhang H. J Mater Chem B. 2019 Dec 21;7(47):7525-7539. doi: 10.1039/c9tb01929d. Epub 2019 Nov 13. PubMed |
| Fanconi-BRCA pathway mutations in childhood T-cell acute lymphoblastic leukemia. Pouliot GP, Degar J, Hinze L, Kochupurakkal B, Vo CD, Burns MA, Moreau L, Ganesa C, Roderick J, Peirs S, Menten B, Loh ML, Hunger SP, Silverman LB, Harris MH, Stevenson KE, Weinstock DM, Weng AP, Van Vlierberghe P, D'Andrea AD, Gutierrez A. PLoS One. 2019 Nov 13;14(11):e0221288. doi: 10.1371/journal.pone.0221288. eCollection 2019. PubMed |
| Lung Mammary Metastases but Not Primary Tumors Induce Accumulation of Atypical Large Platelets and Their Chemokine Expression. Zheng W, Zhang H, Zhao D, Zhang J, Pollard JW. Cell Rep. 2019 Nov 12;29(7):1747-1755.e4. doi: 10.1016/j.celrep.2019.10.016. PubMed |
| DUX4-Induced Histone Variants H3.X and H3.Y Mark DUX4 Target Genes for Expression. Resnick R, Wong CJ, Hamm DC, Bennett SR, Skene PJ, Hake SB, Henikoff S, van der Maarel SM, Tapscott SJ. Cell Rep. 2019 Nov 12;29(7):1812-1820.e5. doi: 10.1016/j.celrep.2019.10.025. PubMed |
| Control of Germinal Center Localization and Lineage Stability of Follicular Regulatory T Cells by the Blimp1 Transcription Factor. Wang L, Shen E, Luo L, Rabe H, Wang Q, Yin J, Yang X, Liu W, Sido JM, Nakagawa H, Ao L, Kim HJ, Cantor H, Leavenworth JW. Cell Rep. 2019 Nov 12;29(7):1848-1861.e6. doi: 10.1016/j.celrep.2019.10.012. PubMed |
| NIX-Mediated Mitophagy Promotes Effector Memory Formation in Antigen-Specific CD8(+) T Cells. Gupta SS, Sharp R, Hofferek C, Kuai L, Dorn GW 2nd, Wang J, Chen M. Cell Rep. 2019 Nov 12;29(7):1862-1877.e7. doi: 10.1016/j.celrep.2019.10.032. PubMed |
| Sox2 and Klf4 as the Functional Core in Pluripotency Induction without Exogenous Oct4. An Z, Liu P, Zheng J, Si C, Li T, Chen Y, Ma T, Zhang MQ, Zhou Q, Ding S. Cell Rep. 2019 Nov 12;29(7):1986-2000.e8. doi: 10.1016/j.celrep.2019.10.026. PubMed |
| eIF4A supports an oncogenic translation program in pancreatic ductal adenocarcinoma. Chan K, Robert F, Oertlin C, Kapeller-Libermann D, Avizonis D, Gutierrez J, Handly-Santana A, Doubrovin M, Park J, Schoepfer C, Da Silva B, Yao M, Gorton F, Shi J, Thomas CJ, Brown LE, Porco JA Jr, Pollak M, Larsson O, Pelletier J, Chio IIC. Nat Commun. 2019 Nov 13;10(1):5151. doi: 10.1038/s41467-019-13086-5. PubMed |
| A substitution mutation in a conserved domain of mammalian acetate-dependent acetyl CoA synthetase 2 results in destabilized protein and impaired HIF-2 signaling. Nagati JS, Xu M, Garcia T, Comerford SA, Hammer RE, Garcia JA. PLoS One. 2019 Nov 14;14(11):e0225105. doi: 10.1371/journal.pone.0225105. eCollection 2019. PubMed |
| Host signaling and EGR1 transcriptional control of human cytomegalovirus replication and latency. Buehler J, Carpenter E, Zeltzer S, Igarashi S, Rak M, Mikell I, Nelson JA, Goodrum F. PLoS Pathog. 2019 Nov 14;15(11):e1008037. doi: 10.1371/journal.ppat.1008037. eCollection 2019 Nov. PubMed |
| In vitro assay for the development of small molecule inhibitors targeting PD-1/PD-L1. Zhai W, Zhou X, Du J, Gao Y. Methods Enzymol. 2019;629:361-381. doi: 10.1016/bs.mie.2019.05.051. Epub 2019 Jun 17. PubMed |
| The KDM5A/RBP2 histone demethylase represses NOTCH signaling to sustain neuroendocrine differentiation and promote small cell lung cancer tumorigenesis. Oser MG, Sabet AH, Gao W, Chakraborty AA, Schinzel AC, Jennings RB, Fonseca R, Bonal DM, Booker MA, Flaifel A, Novak JS, Christensen CL, Zhang H, Herbert ZT, Tolstorukov MY, Buss EJ, Wong KK, Bronson RT, Nguyen QD, Signoretti S, Kaelin WG Jr. Genes Dev. 2019 Dec 1;33(23-24):1718-1738. doi: 10.1101/gad.328336.119. Epub 2019 Nov 14. PubMed |
| SERPINE2 promotes esophageal squamous cell carcinoma metastasis by activating BMP4. Zhang J, Luo A, Huang F, Gong T, Liu Z. Cancer Lett. 2020 Jan 28;469:390-398. doi: 10.1016/j.canlet.2019.11.011. Epub 2019 Nov 12. PubMed |
| A U1i RNA that Enhances HIV-1 RNA Splicing with an Elongated Recognition Domain Is an Optimal Candidate for Combination HIV-1 Gene Therapy. Del Corpo O, Goguen RP, Malard CMG, Daher A, Colby-Germinario S, Scarborough RJ, Gatignol A. Mol Ther Nucleic Acids. 2019 Dec 6;18:815-830. doi: 10.1016/j.omtn.2019.10.011. Epub 2019 Oct 18. PubMed |
The Leukemogenic TCF3-HLF Complex Rewires Enhancers Driving Cellular Identity and Self-Renewal Conferring EP300 Vulnerability.
Huang Y, Mouttet B, Warnatz HJ, Risch T, Rietmann F, Frommelt F, Ngo QA, Dobay MP, Marovca B, Jenni S, Tsai YC, Matzk S, Amstislavskiy V, Schrappe M, Stanulla M, Gstaiger M, Bornhauser B, Yaspo ML, Bourquin JP.
Cancer Cell. 2019 Dec 9;36(6):630-644.e9. doi: 10.1016/j.ccell.2019.10.004. Epub 2019 Nov 14.
PubMed
Associated Plasmids |
| Hemogenic Reprogramming of Human Fibroblasts by Enforced Expression of Transcription Factors. Silverio-Alves R, Gomes AM, Kurochkin I, Moore KA, Pereira CF. J Vis Exp. 2019 Nov 4;(153). doi: 10.3791/60112. PubMed |
Inducible Exoc7/Exo70 knockout reveals a critical role of the exocyst in insulin-regulated GLUT4 exocytosis.
Wang S, Crisman L, Miller J, Datta I, Gulbranson DR, Tian Y, Yin Q, Yu H, Shen J.
J Biol Chem. 2019 Dec 27;294(52):19988-19996. doi: 10.1074/jbc.RA119.010821. Epub 2019 Nov 18.
PubMed
Associated Plasmids |
| Delivery of nitric oxide with a nanocarrier promotes tumour vessel normalization and potentiates anti-cancer therapies. Sung YC, Jin PR, Chu LA, Hsu FF, Wang MR, Chang CC, Chiou SJ, Qiu JT, Gao DY, Lin CC, Chen YS, Hsu YC, Wang J, Wang FN, Yu PL, Chiang AS, Wu AY, Ko JJ, Lai CP, Lu TT, Chen Y. Nat Nanotechnol. 2019 Dec;14(12):1160-1169. doi: 10.1038/s41565-019-0570-3. Epub 2019 Nov 18. PubMed |
| A curative combination cancer therapy achieves high fractional cell killing through low cross-resistance and drug additivity. Palmer AC, Chidley C, Sorger PK. Elife. 2019 Nov 19;8. pii: 50036. doi: 10.7554/eLife.50036. PubMed |
| EPS8 Facilitates Uncoating of Influenza A Virus. Larson GP, Tran V, Yu S, Cai Y, Higgins CA, Smith DM, Baker SF, Radoshitzky SR, Kuhn JH, Mehle A. Cell Rep. 2019 Nov 19;29(8):2175-2183.e4. doi: 10.1016/j.celrep.2019.10.064. PubMed |
| 3D Cellular Architecture Modulates Tyrosine Kinase Activity, Thereby Switching CD95-Mediated Apoptosis to Survival. Gulculer Balta GS, Monzel C, Kleber S, Beaudouin J, Balta E, Kaindl T, Chen S, Gao L, Thiemann M, Wirtz CR, Samstag Y, Tanaka M, Martin-Villalba A. Cell Rep. 2019 Nov 19;29(8):2295-2306.e6. doi: 10.1016/j.celrep.2019.10.054. PubMed |
| Hepatitis Delta Virus Alters the Autophagy Process To Promote Its Genome Replication. Khabir M, Aliche AZ, Sureau C, Blanchet M, Labonte P. J Virol. 2020 Jan 31;94(4). pii: JVI.01936-19. doi: 10.1128/JVI.01936-19. Print 2020 Jan 31. PubMed |
| The ribosomal P-stalk couples amino acid starvation to GCN2 activation in mammalian cells. Harding HP, Ordonez A, Allen F, Parts L, Inglis AJ, Williams RL, Ron D. Elife. 2019 Nov 21;8. pii: 50149. doi: 10.7554/eLife.50149. PubMed |
| Optogenetic control of mesenchymal cell fate towards precise bone regeneration. Wang W, Huang D, Ren J, Li R, Feng Z, Guan C, Bao B, Cai B, Ling J, Zhou C. Theranostics. 2019 Oct 18;9(26):8196-8205. doi: 10.7150/thno.36455. eCollection 2019. PubMed |
| Single-molecule imaging of HIV-1 envelope glycoprotein dynamics and Gag lattice association exposes determinants responsible for virus incorporation. Pezeshkian N, Groves NS, van Engelenburg SB. Proc Natl Acad Sci U S A. 2019 Dec 10;116(50):25269-25277. doi: 10.1073/pnas.1910008116. Epub 2019 Nov 22. PubMed |
| Functional Enhancers Shape Extrachromosomal Oncogene Amplifications. Morton AR, Dogan-Artun N, Faber ZJ, MacLeod G, Bartels CF, Piazza MS, Allan KC, Mack SC, Wang X, Gimple RC, Wu Q, Rubin BP, Shetty S, Angers S, Dirks PB, Sallari RC, Lupien M, Rich JN, Scacheri PC. Cell. 2019 Nov 27;179(6):1330-1341.e13. doi: 10.1016/j.cell.2019.10.039. Epub 2019 Nov 21. PubMed |
| Xenotransplanted Human Cortical Neurons Reveal Species-Specific Development and Functional Integration into Mouse Visual Circuits. Linaro D, Vermaercke B, Iwata R, Ramaswamy A, Libe-Philippot B, Boubakar L, Davis BA, Wierda K, Davie K, Poovathingal S, Penttila PA, Bilheu A, De Bruyne L, Gall D, Conzelmann KK, Bonin V, Vanderhaeghen P. Neuron. 2019 Dec 4;104(5):972-986.e6. doi: 10.1016/j.neuron.2019.10.002. Epub 2019 Nov 21. PubMed |
| BNC1 regulates cell heterogeneity in human pluripotent stem cell-derived epicardium. Gambardella L, McManus SA, Moignard V, Sebukhan D, Delaune A, Andrews S, Bernard WG, Morrison MA, Riley PR, Gottgens B, Gambardella Le Novere N, Sinha S. Development. 2019 Dec 13;146(24). pii: dev.174441. doi: 10.1242/dev.174441. PubMed |
| Entry by multiple picornaviruses is dependent on a pathway that includes TNK2, WASL, and NCK1. Jiang H, Leung C, Tahan S, Wang D. Elife. 2019 Nov 26;8. pii: 50276. doi: 10.7554/eLife.50276. PubMed |
A quantitative single-cell assay for retrograde membrane traffic enables rapid detection of defects in cellular organization.
Luong P, Li Q, Chen PF, Wrighton PJ, Chang D, Dwyer S, Bayer MT, Snapper SB, Hansen SH, Thiagarajah JT, Goessling W, Lencer WI.
Mol Biol Cell. 2019 Nov 27:mbcE19070375. doi: 10.1091/mbc.E19-07-0375.
PubMed
Associated Plasmids |
| Global Analysis of Enhancer Targets Reveals Convergent Enhancer-Driven Regulatory Modules. Xie S, Armendariz D, Zhou P, Duan J, Hon GC. Cell Rep. 2019 Nov 26;29(9):2570-2578.e5. doi: 10.1016/j.celrep.2019.10.073. PubMed |
| The targetable kinase PIM1 drives ALK inhibitor resistance in high-risk neuroblastoma independent of MYCN status. Trigg RM, Lee LC, Prokoph N, Jahangiri L, Reynolds CP, Amos Burke GA, Probst NA, Han M, Matthews JD, Lim HK, Manners E, Martinez S, Pastor J, Blanco-Aparicio C, Merkel O, de Los Fayos Alonso IG, Kodajova P, Tangermann S, Hogler S, Luo J, Kenner L, Turner SD. Nat Commun. 2019 Nov 28;10(1):5428. doi: 10.1038/s41467-019-13315-x. PubMed |
| Evaluation of reference genes for quantitative real-time PCR in Wharton's Jelly-derived mesenchymal stem cells after lentiviral transduction and differentiation. Borkowska P, Zielinska A, Paul-Samojedny M, Stojko R, Kowalski J. Mol Biol Rep. 2020 Feb;47(2):1107-1115. doi: 10.1007/s11033-019-05207-6. Epub 2019 Nov 28. PubMed |
| GPR108 Is a Highly Conserved AAV Entry Factor. Dudek AM, Zabaleta N, Zinn E, Pillay S, Zengel J, Porter C, Franceschini JS, Estelien R, Carette JE, Zhou GL, Vandenberghe LH. Mol Ther. 2020 Feb 5;28(2):367-381. doi: 10.1016/j.ymthe.2019.11.005. Epub 2019 Nov 13. PubMed |
CRISPR-Switch regulates sgRNA activity by Cre recombination for sequential editing of two loci.
Chylinski K, Hubmann M, Hanna RE, Yanchus C, Michlits G, Uijttewaal ECH, Doench J, Schramek D, Elling U.
Nat Commun. 2019 Nov 29;10(1):5454. doi: 10.1038/s41467-019-13403-y.
PubMed
Associated Plasmids |
| KSHV activates unfolded protein response sensors but suppresses downstream transcriptional responses to support lytic replication. Johnston BP, Pringle ES, McCormick C. PLoS Pathog. 2019 Dec 2;15(12):e1008185. doi: 10.1371/journal.ppat.1008185. eCollection 2019 Dec. PubMed |
| ADAP1 promotes invasive squamous cell carcinoma progression and predicts patient survival. Van Duzer A, Taniguchi S, Elhance A, Tsujikawa T, Oshimori N. Life Sci Alliance. 2019 Dec 2;2(6). pii: 2/6/e201900582. doi: 10.26508/lsa.201900582. Print 2019 Dec. PubMed |
| A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity. Khan S, Zhang X, Lv D, Zhang Q, He Y, Zhang P, Liu X, Thummuri D, Yuan Y, Wiegand JS, Pei J, Zhang W, Sharma A, McCurdy CR, Kuruvilla VM, Baran N, Ferrando AA, Kim YM, Rogojina A, Houghton PJ, Huang G, Hromas R, Konopleva M, Zheng G, Zhou D. Nat Med. 2019 Dec;25(12):1938-1947. doi: 10.1038/s41591-019-0668-z. Epub 2019 Dec 2. PubMed |
| Mechanisms of nuclear content loading to exosomes. Yokoi A, Villar-Prados A, Oliphint PA, Zhang J, Song X, De Hoff P, Morey R, Liu J, Roszik J, Clise-Dwyer K, Burks JK, O'Halloran TJ, Laurent LC, Sood AK. Sci Adv. 2019 Nov 20;5(11):eaax8849. doi: 10.1126/sciadv.aax8849. eCollection 2019 Nov. PubMed |
Precise and broad scope genome editing based on high-specificity Cas9 nickases.
Wang Q, Liu J, Janssen JM, Le Bouteiller M, Frock RL, Goncalves MAFV.
Nucleic Acids Res. 2021 Jan 25;49(2):1173-1198. doi: 10.1093/nar/gkaa1236.
PubMed
Associated Plasmids |
| Suppression of Ribosomal Pausing by eIF5A Is Necessary to Maintain the Fidelity of Start Codon Selection. Manjunath H, Zhang H, Rehfeld F, Han J, Chang TC, Mendell JT. Cell Rep. 2019 Dec 3;29(10):3134-3146.e6. doi: 10.1016/j.celrep.2019.10.129. PubMed |
| Exploring the potential of BH3 mimetic therapy in squamous cell carcinoma of the head and neck. Carter RJ, Milani M, Butterworth M, Alotibi A, Harper N, Yedida G, Greaves G, Al-Zebeeby A, Jorgensen AL, Schache AG, Risk JM, Shaw RJ, Jones TM, Sacco JJ, Hurlstone A, Cohen GM, Varadarajan S. Cell Death Dis. 2019 Dec 4;10(12):912. doi: 10.1038/s41419-019-2150-8. PubMed |
| Reactive oxygen/nitrogen species contribute substantially to the antileukemia effect of APO866, a NAD lowering agent. Cloux AJ, Aubry D, Heulot M, Widmann C, ElMokh O, Piacente F, Cea M, Nencioni A, Bellotti A, Bouzourene K, Pellegrin M, Mazzolai L, Duchosal MA, Nahimana A. Oncotarget. 2019 Nov 19;10(62):6723-6738. doi: 10.18632/oncotarget.27336. eCollection 2019 Nov 19. PubMed |
| LRRK2 kinase activity regulates lysosomal glucocerebrosidase in neurons derived from Parkinson's disease patients. Ysselstein D, Nguyen M, Young TJ, Severino A, Schwake M, Merchant K, Krainc D. Nat Commun. 2019 Dec 5;10(1):5570. doi: 10.1038/s41467-019-13413-w. PubMed |
| IL-36gamma drives skin toxicity induced by EGFR/MEK inhibition and commensal Cutibacterium acnes. Satoh TK, Mellett M, Meier-Schiesser B, Fenini G, Otsuka A, Beer HD, Rordorf T, Maul JT, Hafner J, Navarini AA, Contassot E, French LE. J Clin Invest. 2020 Feb 4. pii: 128678. doi: 10.1172/JCI128678. PubMed |
| Deregulation of the Histone Lysine-Specific Demethylase 1 Is Involved in Human Hepatocellular Carcinoma. Kim S, Bolatkan A, Kaneko S, Ikawa N, Asada K, Komatsu M, Hayami S, Ojima H, Abe N, Yamaue H, Hamamoto R. Biomolecules. 2019 Dec 1;9(12). pii: biom9120810. doi: 10.3390/biom9120810. PubMed |
| Nanoscale coupling of endocytic pit growth and stability. Lehmann M, Lukonin I, Noe F, Schmoranzer J, Clementi C, Loerke D, Haucke V. Sci Adv. 2019 Nov 27;5(11):eaax5775. doi: 10.1126/sciadv.aax5775. eCollection 2019 Nov. PubMed |
| CSB promoter downregulation via histone H3 hypoacetylation is an early determinant of replicative senescence. Crochemore C, Fernandez-Molina C, Montagne B, Salles A, Ricchetti M. Nat Commun. 2019 Dec 6;10(1):5576. doi: 10.1038/s41467-019-13314-y. PubMed |
| Galectin-3 Coordinates a Cellular System for Lysosomal Repair and Removal. Jia J, Claude-Taupin A, Gu Y, Choi SW, Peters R, Bissa B, Mudd MH, Allers L, Pallikkuth S, Lidke KA, Salemi M, Phinney B, Mari M, Reggiori F, Deretic V. Dev Cell. 2020 Jan 6;52(1):69-87.e8. doi: 10.1016/j.devcel.2019.10.025. Epub 2019 Dec 5. PubMed |
| GLUL Ablation Can Confer Drug Resistance to Cancer Cells via a Malate-Aspartate Shuttle-Mediated Mechanism. Muthu M, Kumar R, Syed Khaja AS, Gilthorpe JD, Persson JL, Nordstrom A. Cancers (Basel). 2019 Dec 5;11(12). pii: cancers11121945. doi: 10.3390/cancers11121945. PubMed |
| Vitamin D promotes the cisplatin sensitivity of oral squamous cell carcinoma by inhibiting LCN2-modulated NF-kappaB pathway activation through RPS3. Huang Z, Zhang Y, Li H, Zhou Y, Zhang Q, Chen R, Jin T, Hu K, Li S, Wang Y, Chen W, Huang Z. Cell Death Dis. 2019 Dec 9;10(12):936. doi: 10.1038/s41419-019-2177-x. PubMed |
| Nucleic acid-targeted pathogen reduction technique in red blood cells by UV-generated oxygen radicals for optimising recipient safety. Zhang Q, Wu C, Fan Y, Xu T, Meng Q, Wang S, Liu Q, Yao C, Jiang T. Transfus Med. 2019 Dec 10. doi: 10.1111/tme.12654. PubMed |
| Regulated resurfacing of a somatostatin receptor storage compartment fine-tunes pituitary secretion. Alshafie W, Francis V, Bednarz K, Pan YE, Stroh T, McPherson PS. J Cell Biol. 2020 Jan 6;219(1). pii: 132745. doi: 10.1083/jcb.201904054. PubMed |
| Endogenous IGF Signaling Directs Heterogeneous Mesoderm Differentiation in Human Embryonic Stem Cells. Yang Y, Ren Z, Xu F, Meng Y, Zhang Y, Ai N, Long Y, Fok HI, Deng C, Zhao X, Huang L, Zhao Q, Wang J, Liu W, Ge W, Chen G. Cell Rep. 2019 Dec 10;29(11):3374-3384.e5. doi: 10.1016/j.celrep.2019.11.047. PubMed |
| Post-translational Modification of OTULIN Regulates Ubiquitin Dynamics and Cell Death. Douglas T, Saleh M. Cell Rep. 2019 Dec 10;29(11):3652-3663.e5. doi: 10.1016/j.celrep.2019.11.014. PubMed |
| A primate-specific retroviral enhancer wires the XACT lncRNA into the core pluripotency network in humans. Casanova M, Moscatelli M, Chauviere LE, Huret C, Samson J, Liyakat Ali TM, Rosspopoff O, Rougeulle C. Nat Commun. 2019 Dec 11;10(1):5652. doi: 10.1038/s41467-019-13551-1. PubMed |
| Targeting REGNASE-1 programs long-lived effector T cells for cancer therapy. Wei J, Long L, Zheng W, Dhungana Y, Lim SA, Guy C, Wang Y, Wang YD, Qian C, Xu B, Kc A, Saravia J, Huang H, Yu J, Doench JG, Geiger TL, Chi H. Nature. 2019 Dec;576(7787):471-476. doi: 10.1038/s41586-019-1821-z. Epub 2019 Dec 11. PubMed |
| NOTCH1 signaling in oral squamous cell carcinoma via a TEL2/SERPINE1 axis. Salameti V, Bhosale PG, Ames-Draycott A, Sipila K, Watt FM. Oncotarget. 2019 Nov 26;10(63):6791-6804. doi: 10.18632/oncotarget.27306. eCollection 2019 Nov 26. PubMed |
| Significant Role of Dicer and miR-223 in Adipose Tissue of Polycystic Ovary Syndrome Patients. Qin L, Chen J, Tang L, Zuo T, Chen H, Gao R, Xu W. Biomed Res Int. 2019 Nov 11;2019:9193236. doi: 10.1155/2019/9193236. eCollection 2019. PubMed |
| ARID1A prevents squamous cell carcinoma initiation and chemoresistance by antagonizing pRb/E2F1/c-Myc-mediated cancer stemness. Luo Q, Wu X, Chang W, Zhao P, Nan Y, Zhu X, Katz JP, Su D, Liu Z. Cell Death Differ. 2019 Dec 12. pii: 10.1038/s41418-019-0475-6. doi: 10.1038/s41418-019-0475-6. PubMed |
| Telophase correction refines division orientation in stratified epithelia. Lough KJ, Byrd KM, Descovich CP, Spitzer DC, Bergman AJ, Beaudoin GM 3rd, Reichardt LF, Williams SE. Elife. 2019 Dec 13;8. pii: 49249. doi: 10.7554/eLife.49249. PubMed |
| Proteolytic Processing of Neuregulin 2. Czarnek M, Bereta J. Mol Neurobiol. 2019 Dec 14. pii: 10.1007/s12035-019-01846-9. doi: 10.1007/s12035-019-01846-9. PubMed |
| RCC2 promotes breast cancer progression through regulation of Wnt signaling and inducing EMT. Chen Z, Wu W, Huang Y, Xie L, Li Y, Chen H, Li W, Yin D, Hu K. J Cancer. 2019 Nov 1;10(27):6837-6847. doi: 10.7150/jca.36430. eCollection 2019. PubMed |
| Modulation of N-Methyl-N-nitrosourea Mutagenesis in Mouse Embryo Fibroblasts Derived from the gpt Delta Mouse by an Inhibitor of the O(6)-Methylguanine Methyltransferase, MGMT. Thongararm P, Fedeles BI, Khumsubdee S, Armijo AL, Kim L, Thiantanawat A, Promvijit J, Navasumrit P, Ruchirawat M, Croy RG, Essigmann JM. Chem Res Toxicol. 2020 Feb 17;33(2):625-633. doi: 10.1021/acs.chemrestox.9b00444. Epub 2019 Dec 24. PubMed |
| APOBEC3A is a prominent cytidine deaminase in breast cancer. Cortez LM, Brown AL, Dennis MA, Collins CD, Brown AJ, Mitchell D, Mertz TM, Roberts SA. PLoS Genet. 2019 Dec 16;15(12):e1008545. doi: 10.1371/journal.pgen.1008545. eCollection 2019 Dec. PubMed |
| Inhibition of ULK1 and Beclin1 by an alpha-herpesvirus Akt-like Ser/Thr kinase limits autophagy to stimulate virus replication. Rubio RM, Mohr I. Proc Natl Acad Sci U S A. 2019 Dec 16. pii: 1915139116. doi: 10.1073/pnas.1915139116. PubMed |
| Topologically Associated Domains Delineate Susceptibility to Somatic Hypermutation. Senigl F, Maman Y, Dinesh RK, Alinikula J, Seth RB, Pecnova L, Omer AD, Rao SSP, Weisz D, Buerstedde JM, Aiden EL, Casellas R, Hejnar J, Schatz DG. Cell Rep. 2019 Dec 17;29(12):3902-3915.e8. doi: 10.1016/j.celrep.2019.11.039. PubMed |
| LC3C-Mediated Autophagy Selectively Regulates the Met RTK and HGF-Stimulated Migration and Invasion. Bell ES, Coelho PP, Ratcliffe CDH, Rajadurai CV, Peschard P, Vaillancourt R, Zuo D, Park M. Cell Rep. 2019 Dec 17;29(12):4053-4068.e6. doi: 10.1016/j.celrep.2019.11.063. PubMed |
| Spatial Genome Re-organization between Fetal and Adult Hematopoietic Stem Cells. Chen C, Yu W, Tober J, Gao P, He B, Lee K, Trieu T, Blobel GA, Speck NA, Tan K. Cell Rep. 2019 Dec 17;29(12):4200-4211.e7. doi: 10.1016/j.celrep.2019.11.065. PubMed |
| The phytohormone forchlorfenuron decreases viability and proliferation of malignant mesothelioma cells in vitro and in vivo. Blum W, Henzi T, Pecze L, Diep KL, Bochet CG, Schwaller B. Oncotarget. 2019 Dec 10;10(65):6944-6956. doi: 10.18632/oncotarget.27341. eCollection 2019 Dec 10. PubMed |
Molecular Tuning of the Axonal Mitochondrial Ca(2+) Uniporter Ensures Metabolic Flexibility of Neurotransmission.
Ashrafi G, de Juan-Sanz J, Farrell RJ, Ryan TA.
Neuron. 2019 Dec 10. pii: S0896-6273(19)30984-5. doi: 10.1016/j.neuron.2019.11.020.
PubMed
Associated Plasmids |
| The SINEB1 element in the long non-coding RNA Malat1 is necessary for TDP-43 proteostasis. Nguyen TM, Kabotyanski EB, Reineke LC, Shao J, Xiong F, Lee JH, Dubrulle J, Johnson H, Stossi F, Tsoi PS, Choi KJ, Ellis AG, Zhao N, Cao J, Adewunmi O, Ferreon JC, Ferreon ACM, Neilson JR, Mancini MA, Chen X, Kim J, Ma L, Li W, Rosen JM. Nucleic Acids Res. 2020 Mar 18;48(5):2621-2642. doi: 10.1093/nar/gkz1176. PubMed |
| Low-Level Saturated Fatty Acid Palmitate Benefits Liver Cells by Boosting Mitochondrial Metabolism via CDK1-SIRT3-CPT2 Cascade. Liu L, Xie B, Fan M, Candas-Green D, Jiang JX, Wei R, Wang Y, Chen HW, Hu Y, Li JJ. Dev Cell. 2020 Jan 27;52(2):196-209.e9. doi: 10.1016/j.devcel.2019.11.012. Epub 2019 Dec 19. PubMed |
| The stem cell-specific long noncoding RNA HOXA10-AS in the pathogenesis of KMT2A-rearranged leukemia. Al-Kershi S, Bhayadia R, Ng M, Verboon L, Emmrich S, Gack L, Schwarzer A, Strowig T, Heckl D, Klusmann JH. Blood Adv. 2019 Dec 23;3(24):4252-4263. doi: 10.1182/bloodadvances.2019032029. PubMed |
| CRISPR-mediated modeling and functional validation of candidate tumor suppressor genes in small cell lung cancer. Ng SR, Rideout WM 3rd, Akama-Garren EH, Bhutkar A, Mercer KL, Schenkel JM, Bronson RT, Jacks T. Proc Natl Acad Sci U S A. 2020 Jan 7;117(1):513-521. doi: 10.1073/pnas.1821893117. Epub 2019 Dec 23. PubMed |
Subcellular drug targeting illuminates local kinase action.
Bucko PJ, Lombard CK, Rathbun L, Garcia I, Bhat A, Wordeman L, Smith FD, Maly DJ, Hehnly H, Scott JD.
Elife. 2019 Dec 24;8. pii: 52220. doi: 10.7554/eLife.52220.
PubMed
Associated Plasmids |
| Sideroflexin 4 affects Fe-S cluster biogenesis, iron metabolism, mitochondrial respiration and heme biosynthetic enzymes. Paul BT, Tesfay L, Winkler CR, Torti FM, Torti SV. Sci Rep. 2019 Dec 23;9(1):19634. doi: 10.1038/s41598-019-55907-z. PubMed |
| WBP11 is required for splicing the TUBGCP6 pre-mRNA to promote centriole duplication. Park EM, Scott PM, Clutario K, Cassidy KB, Zhan K, Gerber SA, Holland AJ. J Cell Biol. 2020 Jan 6;219(1). pii: 133543. doi: 10.1083/jcb.201904203. PubMed |
| Construction of an Inducible CRISPR/Cas9 System for CXCR4 Gene and Demonstration of its Effects on MKN-45 Cells. Peng Y, Yang T, Tang X, Chen F, Wang S. Cell Biochem Biophys. 2019 Dec 24. pii: 10.1007/s12013-019-00898-x. doi: 10.1007/s12013-019-00898-x. PubMed |
| Molecular Basis for Autosomal-Dominant Renal Fanconi Syndrome Caused by HNF4A. Marchesin V, Perez-Marti A, Le Meur G, Pichler R, Grand K, Klootwijk ED, Kesselheim A, Kleta R, Lienkamp S, Simons M. Cell Rep. 2019 Dec 24;29(13):4407-4421.e5. doi: 10.1016/j.celrep.2019.11.066. PubMed |
| Silencing of Long Non-coding RNA RP1-93H18.6 Acts as a Tumor Suppressor in Cervical Cancer through the Blockade of the PI3K/Akt Axis. Wang Q, Yan SP, Chu DX, Xie Y, Wang CF, Zhang JY, Li WC, Guo RX. Mol Ther Nucleic Acids. 2019 Nov 15;19:304-317. doi: 10.1016/j.omtn.2019.10.041. PubMed |
| Enterovirus 71 Represses Interleukin Enhancer-Binding Factor 2 Production and Nucleus Translocation to Antagonize ILF2 Antiviral Effects. Jin J, Wang W, Ai S, Liu W, Song Y, Luo Z, Zhang Q, Wu K, Liu Y, Wu J. Viruses. 2019 Dec 23;12(1). pii: v12010022. doi: 10.3390/v12010022. PubMed |
| CLIC4 and CLIC1 bridge plasma membrane and cortical actin network for a successful cytokinesis. Uretmen Kagiali ZC, Saner N, Akdag M, Sanal E, Degirmenci BS, Mollaoglu G, Ozlu N. Life Sci Alliance. 2019 Dec 26;3(2). pii: 3/2/e201900558. doi: 10.26508/lsa.201900558. Print 2020 Feb. PubMed |
| Functional Dissection of Mitosis Using Immortalized Fibroblasts from the Indian Muntjac, a Placental Mammal with Only Three Chromosomes. Almeida AC, Drpic D, Okada N, Bravo J, Madureira M, Maiato H. Methods Mol Biol. 2020;2101:247-266. doi: 10.1007/978-1-0716-0219-5_16. PubMed |
| Knocking Out Multiple Genes in Cultured Primary Neurons to Study Tubulin Posttranslational Modifications. Bodakuntla S, Janke C, Magiera MM. Methods Mol Biol. 2020;2101:327-351. doi: 10.1007/978-1-0716-0219-5_19. PubMed |
| Signalling lymphocyte activation molecule family member 9 is found on select subsets of antigen-presenting cells and promotes resistance to Salmonella infection. Wilson TJ, Clare S, Mikulin J, Johnson CM, Harcourt K, Lyons PA, Dougan G, Smith KGC. Immunology. 2020 Apr;159(4):393-403. doi: 10.1111/imm.13169. Epub 2020 Jan 28. PubMed |
| Oncogenic K-ras Induces Mitochondrial OPA3 Expression to Promote Energy Metabolism in Pancreatic Cancer Cells. Meng N, Glorieux C, Zhang Y, Liang L, Zeng P, Lu W, Huang P. Cancers (Basel). 2019 Dec 25;12(1). pii: cancers12010065. doi: 10.3390/cancers12010065. PubMed |
| CDK7 Inhibition Potentiates Genome Instability Triggering Anti-tumor Immunity in Small Cell Lung Cancer. Zhang H, Christensen CL, Dries R, Oser MG, Deng J, Diskin B, Li F, Pan Y, Zhang X, Yin Y, Papadopoulos E, Pyon V, Thakurdin C, Kwiatkowski N, Jani K, Rabin AR, Castro DM, Chen T, Silver H, Huang Q, Bulatovic M, Dowling CM, Sundberg B, Leggett A, Ranieri M, Han H, Li S, Yang A, Labbe KE, Almonte C, Sviderskiy VO, Quinn M, Donaghue J, Wang ES, Zhang T, He Z, Velcheti V, Hammerman PS, Freeman GJ, Bonneau R, Kaelin WG Jr, Sutherland KD, Kersbergen A, Aguirre AJ, Yuan GC, Rothenberg E, Miller G, Gray NS, Wong KK. Cancer Cell. 2020 Jan 13;37(1):37-54.e9. doi: 10.1016/j.ccell.2019.11.003. Epub 2019 Dec 26. PubMed |
| Fumarate and oxidative stress synergize to promote stability of C/EBP homologous protein in the adipocyte. Manuel AM, Walla MD, Dorn MT, Tanis RM, Piroli GG, Frizzell N. Free Radic Biol Med. 2020 Feb 20;148:70-82. doi: 10.1016/j.freeradbiomed.2019.12.037. Epub 2019 Dec 26. PubMed |
| Sonogenetic Modulation of Cellular Activities Using an Engineered Auditory-Sensing Protein. Huang YS, Fan CH, Hsu N, Chiu NH, Wu CY, Chang CY, Wu BH, Hong SR, Chang YC, Yan-Tang Wu A, Guo V, Chiang YC, Hsu WC, Chen L, Pin-Kuang Lai C, Yeh CK, Lin YC. Nano Lett. 2020 Feb 12;20(2):1089-1100. doi: 10.1021/acs.nanolett.9b04373. Epub 2020 Jan 2. PubMed |
| A solid-phase transfection platform for arrayed CRISPR screens. Sercin O, Reither S, Roidos P, Ballin N, Palikyras S, Baginska A, Rein K, Llamazares M, Halavatyi A, Winter H, Muley T, Jurkowska RZ, Abdollahi A, Zenke FT, Neumann B, Mardin BR. Mol Syst Biol. 2019 Dec;15(12):e8983. doi: 10.15252/msb.20198983. PubMed |
| Genes Involved in the Transcriptional Regulation of Pluripotency Are Expressed in Malignant Tumors of the Uterine Cervix and Can Induce Tumorigenic Capacity in a Nontumorigenic Cell Line. Ruiz G, Valencia-Gonzalez HA, Perez-Montiel D, Munoz F, Ocadiz-Delgado R, Fernandez-Retana J, Perez-Plasencia C, Resendis-Antonio O, Gariglio P, Garcia-Carranca A. Stem Cells Int. 2019 Dec 1;2019:7683817. doi: 10.1155/2019/7683817. eCollection 2019. PubMed |
| Cysteine catabolism and the serine biosynthesis pathway support pyruvate production during pyruvate kinase knockdown in pancreatic cancer cells. Yu L, Teoh ST, Ensink E, Ogrodzinski MP, Yang C, Vazquez AI, Lunt SY. Cancer Metab. 2019 Dec 30;7:13. doi: 10.1186/s40170-019-0205-z. eCollection 2019. PubMed |
| Frizzled 1 and Wnt1 as new potential therapeutic targets in the traumatically injured spinal cord. Gonzalez P, Gonzalez-Fernandez C, Campos-Martin Y, Mollejo M, Carballosa-Gautam M, Marcillo A, Norenberg M, Rodriguez FJ. Cell Mol Life Sci. 2020 Jan 3. pii: 10.1007/s00018-019-03427-4. doi: 10.1007/s00018-019-03427-4. PubMed |
| Epigenetic priming by Dot1l in lymphatic endothelial progenitors ensures normal lymphatic development and function. Yoo H, Lee YJ, Park C, Son D, Choi DY, Park JH, Choi HJ, La HW, Choi YJ, Moon EH, Saur D, Chung HM, Song H, Do JT, Jang H, Lee DR, Park C, Lee OH, Cho SG, Hong SH, Kong G, Kim JH, Choi Y, Hong K. Cell Death Dis. 2020 Jan 6;11(1):14. doi: 10.1038/s41419-019-2201-1. PubMed |
RNA isoform screens uncover the essentiality and tumor-suppressor activity of ultraconserved poison exons.
Thomas JD, Polaski JT, Feng Q, De Neef EJ, Hoppe ER, McSharry MV, Pangallo J, Gabel AM, Belleville AE, Watson J, Nkinsi NT, Berger AH, Bradley RK.
Nat Genet. 2020 Jan;52(1):84-94. doi: 10.1038/s41588-019-0555-z. Epub 2020 Jan 7.
PubMed
Associated Plasmids |
| Respiratory supercomplexes act as a platform for complex III-mediated maturation of human mitochondrial complexes I and IV. Protasoni M, Perez-Perez R, Lobo-Jarne T, Harbour ME, Ding S, Penas A, Diaz F, Moraes CT, Fearnley IM, Zeviani M, Ugalde C, Fernandez-Vizarra E. EMBO J. 2020 Feb 3;39(3):e102817. doi: 10.15252/embj.2019102817. Epub 2020 Jan 8. PubMed |
| YAP regulates cell size and growth dynamics via non-cell autonomous mediators. Mugahid D, Kalocsay M, Liu X, Gruver JS, Peshkin L, Kirschner MW. Elife. 2020 Jan 9;9. pii: 53404. doi: 10.7554/eLife.53404. PubMed |
| CRISPR-Cas9-induced IGF1 gene activation as a tool for enhancing muscle differentiation via multiple isoform expression. Roberston MJ, Raghunathan S, Potaman VN, Zhang F, Stewart MD, McConnell BK, Schwartz RJ. FASEB J. 2020 Jan;34(1):555-570. doi: 10.1096/fj.201901107RR. Epub 2019 Nov 25. PubMed |
| Transcription factor NRF2 uses the Hippo pathway effector TAZ to induce tumorigenesis in glioblastomas. Escoll M, Lastra D, Pajares M, Robledinos-Anton N, Rojo AI, Fernandez-Gines R, Mendiola M, Martinez-Marin V, Esteban I, Lopez-Larrubia P, Gargini R, Cuadrado A. Redox Biol. 2020 Feb;30:101425. doi: 10.1016/j.redox.2019.101425. Epub 2020 Jan 2. PubMed |
A fluorescence activatable reporter of flavivirus NS2B-NS3 protease activity enables live imaging of infection in single cells and viral plaques.
Arias-Arias JL, MacPherson DJ, Hill ME, Hardy JA, Mora-Rodriguez R.
J Biol Chem. 2020 Jan 9. pii: RA119.011319. doi: 10.1074/jbc.RA119.011319.
PubMed
Associated Plasmids |
| Artificial escape from XCI by DNA methylation editing of the CDKL5 gene. Halmai JANM, Deng P, Gonzalez CE, Coggins NB, Cameron D, Carter JL, Buchanan FKB, Waldo JJ, Lock SR, Anderson JD, O'Geen H, Segal DJ, Nolta J, Fink KD. Nucleic Acids Res. 2020 Mar 18;48(5):2372-2387. doi: 10.1093/nar/gkz1214. PubMed |
| On-chip 3D neuromuscular model for drug screening and precision medicine in neuromuscular disease. Osaki T, Uzel SGM, Kamm RD. Nat Protoc. 2020 Feb;15(2):421-449. doi: 10.1038/s41596-019-0248-1. Epub 2020 Jan 13. PubMed |
| Increased expression of O-GlcNAc transferase (OGT) is a biomarker for poor prognosis and allows tumorigenesis and invasion in colon cancer. Xu D, Wang W, Bian T, Yang W, Shao M, Yang H. Int J Clin Exp Pathol. 2019 Apr 1;12(4):1305-1314. eCollection 2019. PubMed |
| Epidermal autonomous VEGFA/Flt1/Nrp1 functions mediate psoriasis-like disease. Benhadou F, Glitzner E, Brisebarre A, Swedlund B, Song Y, Dubois C, Rozzi M, Paulissen C, Del Marmol V, Sibilia M, Blanpain C. Sci Adv. 2020 Jan 8;6(2):eaax5849. doi: 10.1126/sciadv.aax5849. eCollection 2020 Jan. PubMed |
| Epigenetic Silencing of CDR1as Drives IGF2BP3-Mediated Melanoma Invasion and Metastasis. Hanniford D, Ulloa-Morales A, Karz A, Berzoti-Coelho MG, Moubarak RS, Sanchez-Sendra B, Kloetgen A, Davalos V, Imig J, Wu P, Vasudevaraja V, Argibay D, Lilja K, Tabaglio T, Monteagudo C, Guccione E, Tsirigos A, Osman I, Aifantis I, Hernando E. Cancer Cell. 2020 Jan 13;37(1):55-70.e15. doi: 10.1016/j.ccell.2019.12.007. PubMed |
| Inhibition of PP2A with LB-100 Enhances Efficacy of CAR-T Cell Therapy Against Glioblastoma. Cui J, Wang H, Medina R, Zhang Q, Xu C, Indig IH, Zhou J, Song Q, Dmitriev P, Sun MY, Guo L, Wang Y, Rosenblum JS, Kovach JS, Gilbert MR, Zhuang Z. Cancers (Basel). 2020 Jan 6;12(1). pii: cancers12010139. doi: 10.3390/cancers12010139. PubMed |
| Oxygen-dependent asparagine hydroxylation of the ubiquitin-associated (UBA) domain in Cezanne regulates ubiquitin binding. Mader J, Huber J, Bonn F, Dotsch V, Rogov VV, Bremm A. J Biol Chem. 2020 Feb 21;295(8):2160-2174. doi: 10.1074/jbc.RA119.010315. Epub 2020 Jan 14. PubMed |
| The Roles of GSK-3beta in Regulation of Retinoid Signaling and Sorafenib Treatment Response in Hepatocellular Carcinoma. Zhang S, Gao W, Tang J, Zhang H, Zhou Y, Liu J, Chen K, Liu F, Li W, To SKY, Wong AST, Zhang XK, Zhou H, Zeng JZ. Theranostics. 2020 Jan 1;10(3):1230-1244. doi: 10.7150/thno.38711. eCollection 2020. PubMed |
| Effects of Benzophenone-3 and Propylparaben on Estrogen Receptor-Dependent R-Loops and DNA Damage in Breast Epithelial Cells and Mice. Majhi PD, Sharma A, Roberts AL, Daniele E, Majewski AR, Chuong LM, Black AL, Vandenberg LN, Schneider SS, Dunphy KA, Jerry DJ. Environ Health Perspect. 2020 Jan;128(1):17002. doi: 10.1289/EHP5221. Epub 2020 Jan 15. PubMed |
| The vitamin D receptor regulates mitochondrial function in C2C12 myoblasts. Ashcroft SP, Bass JJ, Kazi AA, Atherton PJ, Philp A. Am J Physiol Cell Physiol. 2020 Mar 1;318(3):C536-C541. doi: 10.1152/ajpcell.00568.2019. Epub 2020 Jan 15. PubMed |
| The Relative Permittivity Changes of EGF by 50 Hz MF Exposure Neither Affect the Interaction of EGF With EGFR Nor Its Biological Effects. Fei Y, Jin Y, Zhao X, Wang Y, Qian J, Su L, Chen G. Bioelectromagnetics. 2020 Apr;41(3):241-246. doi: 10.1002/bem.22249. Epub 2020 Jan 17. PubMed |
| High-Throughput Screening Identifies Two Novel Small Molecule Enhancers of Recombinant Protein Expression. Chang J, Chen X, Wang R, Shi R, Wang X, Lu W, Ma S, Xia Q. Molecules. 2020 Jan 15;25(2). pii: molecules25020353. doi: 10.3390/molecules25020353. PubMed |
| An ultra-stable cytoplasmic antibody engineered for in vivo applications. Kabayama H, Takeuchi M, Tokushige N, Muramatsu SI, Kabayama M, Fukuda M, Yamada Y, Mikoshiba K. Nat Commun. 2020 Jan 17;11(1):336. doi: 10.1038/s41467-019-13654-9. PubMed |
A human ciliopathy reveals essential functions for NEK10 in airway mucociliary clearance.
Chivukula RR, Montoro DT, Leung HM, Yang J, Shamseldin HE, Taylor MS, Dougherty GW, Zariwala MA, Carson J, Daniels MLA, Sears PR, Black KE, Hariri LP, Almogarri I, Frenkel EM, Vinarsky V, Omran H, Knowles MR, Tearney GJ, Alkuraya FS, Sabatini DM.
Nat Med. 2020 Jan 20. pii: 10.1038/s41591-019-0730-x. doi: 10.1038/s41591-019-0730-x.
PubMed
Associated Plasmids |
| Rare and private spliceosomal gene mutations drive partial, complete, and dual phenocopies of hotspot alterations. Pangallo J, Kiladjian JJ, Cassinat B, Renneville A, Taylor J, Polaski JT, North K, Abdel-Wahab O, Bradley RK. Blood. 2020 Mar 26;135(13):1032-1043. doi: 10.1182/blood.2019002894. PubMed |
| Investigating Chaperonin-Containing TCP-1 subunit 2 as an essential component of the chaperonin complex for tumorigenesis. Showalter AE, Martini AC, Nierenberg D, Hosang K, Fahmi NA, Gopalan P, Khaled AS, Zhang W, Khaled AR. Sci Rep. 2020 Jan 21;10(1):798. doi: 10.1038/s41598-020-57602-w. PubMed |
| Silencing of SENP2 in Multiple Myeloma Induces Bortezomib Resistance by Activating NF-kappaB Through the Modulation of IkappaBalpha Sumoylation. Xie H, Gu Y, Wang W, Wang X, Ye X, Xin C, Lu M, Reddy BA, Shu P. Sci Rep. 2020 Jan 21;10(1):766. doi: 10.1038/s41598-020-57698-0. PubMed |
| A Comprehensive Map of the Monocyte-Derived Dendritic Cell Transcriptional Network Engaged upon Innate Sensing of HIV. Johnson JS, De Veaux N, Rives AW, Lahaye X, Lucas SY, Perot BP, Luka M, Garcia-Paredes V, Amon LM, Watters A, Abdessalem G, Aderem A, Manel N, Littman DR, Bonneau R, Menager MM. Cell Rep. 2020 Jan 21;30(3):914-931.e9. doi: 10.1016/j.celrep.2019.12.054. PubMed |
| Generalizable sgRNA design for improved CRISPR/Cas9 editing efficiency. Hiranniramol K, Chen Y, Liu W, Wang X. Bioinformatics. 2020 May 1;36(9):2684-2689. doi: 10.1093/bioinformatics/btaa041. PubMed |
| A role for ceramide glycosylation in resistance to oxaliplatin in colorectal cancer. Madigan JP, Robey RW, Poprawski JE, Huang H, Clarke CJ, Gottesman MM, Cabot MC, Rosenberg DW. Exp Cell Res. 2020 Mar 15;388(2):111860. doi: 10.1016/j.yexcr.2020.111860. Epub 2020 Jan 20. PubMed |
| Noncoding mutations target cis-regulatory elements of the FOXA1 plexus in prostate cancer. Zhou S, Hawley JR, Soares F, Grillo G, Teng M, Madani Tonekaboni SA, Hua JT, Kron KJ, Mazrooei P, Ahmed M, Arlidge C, Yun HY, Livingstone J, Huang V, Yamaguchi TN, Espiritu SMG, Zhu Y, Severson TM, Murison A, Cameron S, Zwart W, van der Kwast T, Pugh TJ, Fraser M, Boutros PC, Bristow RG, He HH, Lupien M. Nat Commun. 2020 Jan 23;11(1):441. doi: 10.1038/s41467-020-14318-9. PubMed |
| Restoring Wnt6 signaling ameliorates behavioral deficits in MeCP2 T158A mouse model of Rett syndrome. Hsu WL, Ma YL, Liu YC, Tai DJC, Lee EHY. Sci Rep. 2020 Jan 23;10(1):1074. doi: 10.1038/s41598-020-57745-w. PubMed |
| A CRISPR/Cas9 genome editing pipeline in the EndoC-betaH1 cell line to study genes implicated in beta cell function. Grotz AK, Abaitua F, Navarro-Guerrero E, Hastoy B, Ebner D, Gloyn AL. Wellcome Open Res. 2020 Apr 29;4:150. doi: 10.12688/wellcomeopenres.15447.2. eCollection 2019. PubMed |
| scMAGeCK links genotypes with multiple phenotypes in single-cell CRISPR screens. Yang L, Zhu Y, Yu H, Cheng X, Chen S, Chu Y, Huang H, Zhang J, Li W. Genome Biol. 2020 Jan 24;21(1):19. doi: 10.1186/s13059-020-1928-4. PubMed |
IL-4 controls activated neutrophil FcgammaR2b expression and migration into inflamed joints.
Panda SK, Wigerblad G, Jiang L, Jimenez-Andrade Y, Iyer VS, Shen Y, Boddul SV, Guerreiro-Cacais AO, Raposo B, Kasza Z, Wermeling F.
Proc Natl Acad Sci U S A. 2020 Jan 24. pii: 1914186117. doi: 10.1073/pnas.1914186117.
PubMed
Associated Plasmids |
| ABC transporters control ATP release through cholesterol-dependent volume-regulated anion channel activity. Dunn PJ, Salm EJ, Tomita S. J Biol Chem. 2020 Apr 17;295(16):5192-5203. doi: 10.1074/jbc.RA119.010699. Epub 2020 Jan 27. PubMed |
| The mechanism of how CD95/Fas activates the Type I IFN/STAT1 axis, driving cancer stemness in breast cancer. Qadir AS, Stults AM, Murmann AE, Peter ME. Sci Rep. 2020 Jan 28;10(1):1310. doi: 10.1038/s41598-020-58211-3. PubMed |
| WDR5 is a conserved regulator of protein synthesis gene expression. Bryan AF, Wang J, Howard GC, Guarnaccia AD, Woodley CM, Aho ER, Rellinger EJ, Matlock BK, Flaherty DK, Lorey SL, Chung DH, Fesik SW, Liu Q, Weissmiller AM, Tansey WP. Nucleic Acids Res. 2020 Apr 6;48(6):2924-2941. doi: 10.1093/nar/gkaa051. PubMed |
| The m6A reader YTHDF1 promotes ovarian cancer progression via augmenting EIF3C translation. Liu T, Wei Q, Jin J, Luo Q, Liu Y, Yang Y, Cheng C, Li L, Pi J, Si Y, Xiao H, Li L, Rao S, Wang F, Yu J, Yu J, Zou D, Yi P. Nucleic Acids Res. 2020 Apr 17;48(7):3816-3831. doi: 10.1093/nar/gkaa048. PubMed |
| Optimized Pre-Clinical Grade Production of Two Novel Lentiviral Vector Pseudotypes for Lung Gene Delivery. Rosales Gerpe MC, van Lieshout LP, Domm JM, van Vloten JP, Datu J, Ingrao JC, Yu DL, de Jong J, Moraes TJ, Krell PJ, Bridle BW, Wootton SK. Hum Gene Ther. 2020 Apr;31(7-8):459-471. doi: 10.1089/hum.2019.211. Epub 2020 Mar 30. PubMed |
| Matrix Gla protein regulates adipogenesis and is serum marker of visceral adiposity. Li C, Li J, He F, Li K, Li X, Zhang Y. Adipocyte. 2020 Dec;9(1):68-76. doi: 10.1080/21623945.2020.1721692. PubMed |
| Protein tyrosine phosphatase 4A3 (PTP4A3/PRL-3) drives migration and progression of T-cell acute lymphoblastic leukemia in vitro and in vivo. Wei M, Haney MG, Rivas DR, Blackburn JS. Oncogenesis. 2020 Jan 30;9(1):6. doi: 10.1038/s41389-020-0192-5. PubMed |
| Tumor heterogeneity and clonal cooperation influence the immune selection of IFN-gamma-signaling mutant cancer cells. Williams JB, Li S, Higgs EF, Cabanov A, Wang X, Huang H, Gajewski TF. Nat Commun. 2020 Jan 30;11(1):602. doi: 10.1038/s41467-020-14290-4. PubMed |
| KANSL2 and MBNL3 are regulators of pancreatic ductal adenocarcinoma invasion. Oladimeji PO, Bakke J, Wright WC, Chen T. Sci Rep. 2020 Jan 30;10(1):1485. doi: 10.1038/s41598-020-58448-y. PubMed |
| Serine phosphorylation of the small phosphoprotein ICAP1 inhibits its nuclear accumulation. Su VL, Simon B, Draheim KM, Calderwood DA. J Biol Chem. 2020 Mar 6;295(10):3269-3284. doi: 10.1074/jbc.RA119.009794. Epub 2020 Jan 31. PubMed |
| Loss of hnRNPA2B1 inhibits malignant capability and promotes apoptosis via down-regulating Lin28B expression in ovarian cancer. Yang Y, Wei Q, Tang Y, Yuanyuan Wang, Luo Q, Zhao H, He M, Wang H, Zeng Q, Lu W, Xu J, Liu T, Yi P. Cancer Lett. 2020 Apr 10;475:43-52. doi: 10.1016/j.canlet.2020.01.029. Epub 2020 Jan 29. PubMed |
| Inhibition of the deubiquitinase USP10 induces degradation of SYK. Yang J, Meng C, Weisberg E, Case A, Lamberto I, Magin RS, Adamia S, Wang J, Gray N, Liu S, Stone R, Sattler M, Buhrlage S, Griffin JD. Br J Cancer. 2020 Apr;122(8):1175-1184. doi: 10.1038/s41416-020-0731-z. Epub 2020 Feb 4. PubMed |
| Modulation of sulfur assimilation metabolic toxicity overcomes anemia and hemochromatosis in mice. Hale AT, Brown RE, Luka Z, Hudson BH, Matta P, Williams CS, York JD. Adv Biol Regul. 2020 May;76:100694. doi: 10.1016/j.jbior.2020.100694. Epub 2020 Jan 26. PubMed |
| CRISPR/Cas9 increases mitotic gene conversion in human cells. Javidi-Parsijani P, Lyu P, Makani V, Sarhan WM, Yoo KW, El-Korashi L, Atala A, Lu B. Gene Ther. 2020 Jun;27(6):281-296. doi: 10.1038/s41434-020-0126-z. Epub 2020 Feb 4. PubMed |
| MTR4 drives liver tumorigenesis by promoting cancer metabolic switch through alternative splicing. Yu L, Kim J, Jiang L, Feng B, Ying Y, Ji KY, Tang Q, Chen W, Mai T, Dou W, Zhou J, Xiang LY, He YF, Yang D, Li Q, Fu X, Xu Y. Nat Commun. 2020 Feb 5;11(1):708. doi: 10.1038/s41467-020-14437-3. PubMed |
| Tissue-specific promoter-based reporter system for monitoring cell differentiation from iPSCs to cardiomyocytes. Fiedorowicz K, Rozwadowska N, Zimna A, Malcher A, Tutak K, Szczerbal I, Nowicka-Bauer K, Nowaczyk M, Kolanowski TJ, Labedz W, Kubaszewski L, Kurpisz M. Sci Rep. 2020 Feb 5;10(1):1895. doi: 10.1038/s41598-020-58050-2. PubMed |
| Systematic functional identification of cancer multi-drug resistance genes. Lau MT, Ghazanfar S, Parkin A, Chou A, Rouaen JR, Littleboy JB, Nessem D, Khuong TM, Nevoltris D, Schofield P, Langley D, Christ D, Yang J, Pajic M, Neely GG. Genome Biol. 2020 Feb 7;21(1):27. doi: 10.1186/s13059-020-1940-8. PubMed |
| Delete_Genetic screens in isogenic mammalian cell lines without single cell cloning. DeWeirdt PC, Sangree AK, Hanna RE, Sanson KR, Hegde M, Strand C, Persky NS, Doench JG. Nat Commun. 2020 Feb 6;11(1):752. doi: 10.1038/s41467-020-14620-6. PubMed |
| Synergistic lethality between PARP-trapping and alantolactone-induced oxidative DNA damage in homologous recombination-proficient cancer cells. Wang H, Zhang S, Song L, Qu M, Zou Z. Oncogene. 2020 Apr;39(14):2905-2920. doi: 10.1038/s41388-020-1191-x. Epub 2020 Feb 6. PubMed |
| Roscovitine enhances All-trans retinoic acid (ATRA)-induced leukemia cell differentiation: Novel effects on signaling molecules for a putative Cdk2 inhibitor. Rashid A, Duan X, Gao F, Yang M, Yen A. Cell Signal. 2020 Jul;71:109555. doi: 10.1016/j.cellsig.2020.109555. Epub 2020 Feb 4. PubMed |
| BRCA1 and S phase DNA repair pathways restrict LINE-1 retrotransposition in human cells. Mita P, Sun X, Fenyo D, Kahler DJ, Li D, Agmon N, Wudzinska A, Keegan S, Bader JS, Yun C, Boeke JD. Nat Struct Mol Biol. 2020 Feb;27(2):179-191. doi: 10.1038/s41594-020-0374-z. Epub 2020 Feb 10. PubMed |
| Blunted Vagal Cocaine- and Amphetamine-Regulated Transcript Promotes Hyperphagia and Weight Gain. Lee SJ, Krieger JP, Vergara M, Quinn D, McDougle M, de Araujo A, Darling R, Zollinger B, Anderson S, Pan A, Simonnet EJ, Pignalosa A, Arnold M, Singh A, Langhans W, Raybould HE, de Lartigue G. Cell Rep. 2020 Feb 11;30(6):2028-2039.e4. doi: 10.1016/j.celrep.2020.01.045. PubMed |
| Inhibition of USP9X Downregulates JAK2-V617F and Induces Apoptosis Synergistically with BH3 Mimetics Preferentially in Ruxolitinib-Persistent JAK2-V617F-Positive Leukemic Cells. Akiyama H, Umezawa Y, Watanabe D, Okada K, Ishida S, Nogami A, Miura O. Cancers (Basel). 2020 Feb 10;12(2). pii: cancers12020406. doi: 10.3390/cancers12020406. PubMed |
Mechanical regulation of glycolysis via cytoskeleton architecture.
Park JS, Burckhardt CJ, Lazcano R, Solis LM, Isogai T, Li L, Chen CS, Gao B, Minna JD, Bachoo R, DeBerardinis RJ, Danuser G.
Nature. 2020 Feb 12. pii: 10.1038/s41586-020-1998-1. doi: 10.1038/s41586-020-1998-1.
PubMed
Associated Plasmids |
| Cell-Penetrating Nanoparticles Activate the Inflammasome to Enhance Antibody Production by Targeting Microtubule-Associated Protein 1-Light Chain 3 for Degradation. Zhu M, Du L, Zhao R, Wang HY, Zhao Y, Nie G, Wang RF. ACS Nano. 2020 Mar 24;14(3):3703-3717. doi: 10.1021/acsnano.0c00962. Epub 2020 Feb 20. PubMed |
| B cells infected with Type 2 Epstein-Barr virus (EBV) have increased NFATc1/NFATc2 activity and enhanced lytic gene expression in comparison to Type 1 EBV infection. Romero-Masters JC, Huebner SM, Ohashi M, Bristol JA, Benner BE, Barlow EA, Turk GL, Nelson SE, Baiu DC, Van Sciver N, Ranheim EA, Gumperz J, Sherer NM, Farrell PJ, Johannsen EC, Kenney SC. PLoS Pathog. 2020 Feb 14;16(2):e1008365. doi: 10.1371/journal.ppat.1008365. eCollection 2020 Feb. PubMed |
| Interleukin-10 delivered by mesenchymal stem cells attenuates experimental autoimmune myocarditis. Shao M, Wang D, Zhou Y, Du K, Liu W. Int Immunopharmacol. 2020 Apr;81:106212. doi: 10.1016/j.intimp.2020.106212. Epub 2020 Feb 13. PubMed |
| Inhibition of USP7 activity selectively eliminates senescent cells in part via restoration of p53 activity. He Y, Li W, Lv D, Zhang X, Zhang X, Ortiz YT, Budamagunta V, Campisi J, Zheng G, Zhou D. Aging Cell. 2020 Mar;19(3):e13117. doi: 10.1111/acel.13117. Epub 2020 Feb 16. PubMed |
Chemogenetic Control of Nanobodies.
Farrants H, Tarnawski M, Muller TG, Otsuka S, Hiblot J, Koch B, Kueblbeck M, Krausslich HG, Ellenberg J, Johnsson K.
Nat Methods. 2020 Feb 17. pii: 10.1038/s41592-020-0746-7. doi: 10.1038/s41592-020-0746-7.
PubMed
Associated Plasmids |
| Endogenous Retrovirus Activation as a Key Mechanism of Anti-Tumor Immune Response in Radiotherapy. Lee AK, Pan D, Bao X, Hu M, Li F, Li CY. Radiat Res. 2020 Apr;193(4):305-317. doi: 10.1667/RADE-20-00013. Epub 2020 Feb 19. PubMed |
| Lineage reprogramming of fibroblasts into induced cardiac progenitor cells by CRISPR/Cas9-based transcriptional activators. Wang J, Jiang X, Zhao L, Zuo S, Chen X, Zhang L, Lin Z, Zhao X, Qin Y, Zhou X, Yu XY. Acta Pharm Sin B. 2020 Feb;10(2):313-326. doi: 10.1016/j.apsb.2019.09.003. Epub 2019 Sep 17. PubMed |
| Association of BRCA Mutations and BRCAness Status With Anticancer Drug Sensitivities in Triple-Negative Breast Cancer Cell Lines Teraoka S, Muguruma M, Takano N, Miyahara K, Kawate T, Kaise H, Yamada K, Miyazawa K, Ishikawa T. J Surg Res. 2020 Jun;250:200-208. doi: 10.1016/j.jss.2019.12.040. Epub 2020 Feb 21. PubMed |
| Studies of Non-Protective Autophagy Provide Evidence that Recovery from Therapy-Induced Senescence is Independent of Early Autophagy. Saleh T, Tyutyunyk-Massey L, Patel NH, Cudjoe EK Jr, Alotaibi M, Gewirtz DA. Int J Mol Sci. 2020 Feb 20;21(4). pii: ijms21041427. doi: 10.3390/ijms21041427. PubMed |
| A universal reporter cell line for bioactivity evaluation of engineered cytokine products. Mock J, Pellegrino C, Neri D. Sci Rep. 2020 Feb 24;10(1):3234. doi: 10.1038/s41598-020-60182-4. PubMed |
| Optimization of recombinant Zika virus NS1 protein secretion from HEK293 cells. Roldan JS, Cassola A, Castillo DS. Biotechnol Rep (Amst). 2020 Feb 11;25:e00434. doi: 10.1016/j.btre.2020.e00434. eCollection 2020 Mar. PubMed |
| MYC Regulation of D2HGDH and L2HGDH Influences the Epigenome and Epitranscriptome. Qiu Z, Lin AP, Jiang S, Elkashef SM, Myers J, Srikantan S, Sasi B, Cao JZ, Godley LA, Rakheja D, Lyu Y, Zheng S, Madesh M, Shiio Y, Dahia PLM, Aguiar RCT. Cell Chem Biol. 2020 May 21;27(5):538-550.e7. doi: 10.1016/j.chembiol.2020.02.002. Epub 2020 Feb 25. PubMed |
| KLF16 Affects the MYC Signature and Tumor Growth in Prostate Cancer. Zhang J, Yu W, Wang X, Hu B, Wu D, Shi G. Onco Targets Ther. 2020 Feb 13;13:1303-1310. doi: 10.2147/OTT.S233495. eCollection 2020. PubMed |
| NOTCH4 maintains quiescent mesenchymal-like breast cancer stem cells via transcriptionally activating SLUG and GAS1 in triple-negative breast cancer. Zhou L, Wang D, Sheng D, Xu J, Chen W, Qin Y, Du R, Yang X, He X, Xie N, Liu S, Zhang L. Theranostics. 2020 Jan 19;10(5):2405-2421. doi: 10.7150/thno.38875. eCollection 2020. PubMed |
| Caloric Restriction Reprograms the Single-Cell Transcriptional Landscape of Rattus Norvegicus Aging. Ma S, Sun S, Geng L, Song M, Wang W, Ye Y, Ji Q, Zou Z, Wang S, He X, Li W, Esteban CR, Long X, Guo G, Chan P, Zhou Q, Belmonte JCI, Zhang W, Qu J, Liu GH. Cell. 2020 Mar 5;180(5):984-1001.e22. doi: 10.1016/j.cell.2020.02.008. Epub 2020 Feb 27. PubMed |
| Mutation-Dependent Pathomechanisms Determine the Phenotype in the Bestrophinopathies. Nachtigal AL, Milenkovic A, Brandl C, Schulz HL, Duerr LMJ, Lang GE, Reiff C, Herrmann P, Kellner U, Weber BHF. Int J Mol Sci. 2020 Feb 26;21(5). pii: ijms21051597. doi: 10.3390/ijms21051597. PubMed |
| Acid Ceramidase Depletion Impairs Neuronal Survival and Induces Morphological Defects in Neurites Associated with Altered Gene Transcription and Sphingolipid Content. Kyriakou K, Lederer CW, Kleanthous M, Drousiotou A, Malekkou A. Int J Mol Sci. 2020 Feb 26;21(5). pii: ijms21051607. doi: 10.3390/ijms21051607. PubMed |
| A CRISPR-Cas9-based reporter system for single-cell detection of extracellular vesicle-mediated functional transfer of RNA. de Jong OG, Murphy DE, Mager I, Willms E, Garcia-Guerra A, Gitz-Francois JJ, Lefferts J, Gupta D, Steenbeek SC, van Rheenen J, El Andaloussi S, Schiffelers RM, Wood MJA, Vader P. Nat Commun. 2020 Feb 28;11(1):1113. doi: 10.1038/s41467-020-14977-8. PubMed |
| Ligand-dependent internalization of Bombyx mori tachykinin-related peptide receptor is regulated by PKC, GRK5 and beta-arrestin2/BmKurtz. He X, Yan L, Wu Q, Zhang G, Zhou N. Biochim Biophys Acta Mol Cell Res. 2020 Jun;1867(6):118690. doi: 10.1016/j.bbamcr.2020.118690. Epub 2020 Feb 26. PubMed |
| Saccharide analog, 2-deoxy-d-glucose enhances 4-1BB-mediated antitumor immunity via PD-L1 deglycosylation. Kim B, Sun R, Oh W, Kim AMJ, Schwarz JR, Lim SO. Mol Carcinog. 2020 Jul;59(7):691-700. doi: 10.1002/mc.23170. Epub 2020 Mar 1. PubMed |
| The E3 Ubiquitin Ligase SIAH1 Targets MyD88 for Proteasomal Degradation During Dengue Virus Infection. Murphy Schafer AR, Smith JL, Pryke KM, DeFilippis VR, Hirsch AJ. Front Microbiol. 2020 Feb 14;11:24. doi: 10.3389/fmicb.2020.00024. eCollection 2020. PubMed |
| A Preclinical Embryonic Zebrafish Xenograft Model to Investigate CAR T Cells In Vivo. Pascoal S, Salzer B, Scheuringer E, Wenninger-Weinzierl A, Sturtzel C, Holter W, Taschner-Mandl S, Lehner M, Distel M. Cancers (Basel). 2020 Feb 29;12(3). pii: cancers12030567. doi: 10.3390/cancers12030567. PubMed |
| gscreend: modelling asymmetric count ratios in CRISPR screens to decrease experiment size and improve phenotype detection. Imkeller K, Ambrosi G, Boutros M, Huber W. Genome Biol. 2020 Mar 2;21(1):53. doi: 10.1186/s13059-020-1939-1. PubMed |
| Plakophilin 3 phosphorylation by ribosomal S6 kinases supports desmosome assembly. Muller L, Rietscher K, Keil R, Neuholz M, Hatzfeld M. J Cell Sci. 2020 Apr 16;133(8). pii: jcs.238295. doi: 10.1242/jcs.238295. PubMed |
| Melanoma-Secreted Lysosomes Trigger Monocyte-Derived Dendritic Cell Apoptosis and Limit Cancer Immunotherapy. Santana-Magal N, Farhat-Younis L, Gutwillig A, Gleiberman A, Rasoulouniriana D, Tal L, Netanely D, Shamir R, Blau R, Feinmesser M, Zlotnik O, Gutman H, Linde IL, Reticker-Flynn NE, Rider P, Carmi Y. Cancer Res. 2020 May 15;80(10):1942-1956. doi: 10.1158/0008-5472.CAN-19-2944. Epub 2020 Mar 3. PubMed |
| Bacteria Boost Mammalian Host NAD Metabolism by Engaging the Deamidated Biosynthesis Pathway. Shats I, Williams JG, Liu J, Makarov MV, Wu X, Lih FB, Deterding LJ, Lim C, Xu X, Randall TA, Lee E, Li W, Fan W, Li JL, Sokolsky M, Kabanov AV, Li L, Migaud ME, Locasale JW, Li X. Cell Metab. 2020 Mar 3;31(3):564-579.e7. doi: 10.1016/j.cmet.2020.02.001. PubMed |
High-Throughput Screens of PAM-Flexible Cas9 Variants for Gene Knockout and Transcriptional Modulation.
Legut M, Daniloski Z, Xue X, McKenzie D, Guo X, Wessels HH, Sanjana NE.
Cell Rep. 2020 Mar 3;30(9):2859-2868.e5. doi: 10.1016/j.celrep.2020.02.010.
PubMed
Associated Plasmids
|
| Challenges and Reinterpretation of Antibody-Based Research on Phosphorylation of Tyr(307) on PP2Ac. Mazhar S, Leonard D, Sosa A, Schlatzer D, Thomas D, Narla G. Cell Rep. 2020 Mar 3;30(9):3164-3170.e3. doi: 10.1016/j.celrep.2020.02.012. PubMed |
| Locally acting transcription factors regulate p53-dependent cis-regulatory element activity. Catizone AN, Uzunbas GK, Celadova P, Kuang S, Bose D, Sammons MA. Nucleic Acids Res. 2020 May 7;48(8):4195-4213. doi: 10.1093/nar/gkaa147. PubMed |
| SIRT2 protects peripheral neurons from cisplatin-induced injury by enhancing nucleotide excision repair. Zhang M, Du W, Acklin S, Jin S, Xia F. J Clin Invest. 2020 Jun 1;130(6):2953-2965. doi: 10.1172/JCI123159. PubMed |
| Serine Biosynthesis Pathway Supports MYC-miR-494-EZH2 Feed-Forward Circuit Necessary to Maintain Metabolic and Epigenetic Reprogramming of Burkitt Lymphoma Cells. Bialopiotrowicz E, Noyszewska-Kania M, Kachamakova-Trojanowska N, Loboda A, Cybulska M, Grochowska A, Kopczynski M, Mikula M, Prochorec-Sobieszek M, Firczuk M, Graczyk-Jarzynka A, Zagozdzon R, Zabek A, Mlynarz P, Dulak J, Gorniak P, Szydlowski M, Pyziak K, Martyka J, Sroka-Porada A, Jablonska E, Polak A, Kowalczyk P, Szumera-Cieckiewicz A, Chapuy B, Rzymski T, Brzozka K, Juszczynski P. Cancers (Basel). 2020 Mar 3;12(3). pii: cancers12030580. doi: 10.3390/cancers12030580. PubMed |
| Cryptochromes modulate E2F family transcription factors. Chan AB, Huber AL, Lamia KA. Sci Rep. 2020 Mar 5;10(1):4077. doi: 10.1038/s41598-020-61087-y. PubMed |
| Modulation of Transient Receptor Potential Channels 3 and 6 Regulates Osteoclast Function with Impact on Trabecular Bone Loss. Klein S, Mentrup B, Timmen M, Sherwood J, Lindemann O, Fobker M, Kronenberg D, Pap T, Raschke MJ, Stange R. Calcif Tissue Int. 2020 Jun;106(6):655-664. doi: 10.1007/s00223-020-00673-8. Epub 2020 Mar 5. PubMed |
| Fluctuation-Based Super-Resolution Traction Force Microscopy. Stubb A, Laine RF, Miihkinen M, Hamidi H, Guzman C, Henriques R, Jacquemet G, Ivaska J. Nano Lett. 2020 Apr 8;20(4):2230-2245. doi: 10.1021/acs.nanolett.9b04083. Epub 2020 Mar 20. PubMed |
Blackjack mutations improve the on-target activities of increased fidelity variants of SpCas9 with 5'G-extended sgRNAs.
Kulcsar PI, Talas A, Toth E, Nyeste A, Ligeti Z, Welker Z, Welker E.
Nat Commun. 2020 Mar 6;11(1):1223. doi: 10.1038/s41467-020-15021-5.
PubMed
Associated Plasmids
|
| Prioritizing disease and trait causal variants at the TNFAIP3 locus using functional and genomic features. Ray JP, de Boer CG, Fulco CP, Lareau CA, Kanai M, Ulirsch JC, Tewhey R, Ludwig LS, Reilly SK, Bergman DT, Engreitz JM, Issner R, Finucane HK, Lander ES, Regev A, Hacohen N. Nat Commun. 2020 Mar 6;11(1):1237. doi: 10.1038/s41467-020-15022-4. PubMed |
| Interferon inducible GBPs restrict Burkholderia thailandensis motility induced cell-cell fusion. Place DE, Briard B, Samir P, Karki R, Bhattacharya A, Guy CS, Peters JL, Frase S, Vogel P, Neale G, Yamamoto M, Kanneganti TD. PLoS Pathog. 2020 Mar 9;16(3):e1008364. doi: 10.1371/journal.ppat.1008364. eCollection 2020 Mar. PubMed |
| MPV17 does not control cancer cell proliferation. Canonne M, Wanet A, Nguyen TTA, Khelfi A, Ayama-Canden S, Van Steenbrugge M, Fattaccioli A, Sokal E, Najimi M, Arnould T, Renard P. PLoS One. 2020 Mar 10;15(3):e0229834. doi: 10.1371/journal.pone.0229834. eCollection 2020. PubMed |
Potent CRISPR-Cas9 inhibitors from Staphylococcus genomes.
Watters KE, Shivram H, Fellmann C, Lew RJ, McMahon B, Doudna JA.
Proc Natl Acad Sci U S A. 2020 Mar 10. pii: 1917668117. doi: 10.1073/pnas.1917668117.
PubMed
Associated Plasmids |
| Barrier-to-Autointegration Factor 1 Protects against a Basal cGAS-STING Response. Ma H, Qian W, Bambouskova M, Collins PL, Porter SI, Byrum AK, Zhang R, Artyomov M, Oltz EM, Mosammaparast N, Miner JJ, Diamond MS. mBio. 2020 Mar 10;11(2). pii: mBio.00136-20. doi: 10.1128/mBio.00136-20. PubMed |
| Dishevelled 1-Regulated Superpotent Cancer Stem Cells Mediate Wnt Heterogeneity and Tumor Progression in Hepatocellular Carcinoma. Liao WY, Hsu CC, Chan TS, Yen CJ, Chen WY, Pan HW, Tsai KK. Stem Cell Reports. 2020 Mar 10;14(3):462-477. doi: 10.1016/j.stemcr.2020.02.003. PubMed |
| Convergent Met and voltage-gated Ca(2+) channel signaling drives hypermigration of Toxoplasma-infected dendritic cells. Olafsson EB, Ten Hoeve AL, Li-Wang X, Westermark L, Varas-Godoy M, Barragan A. J Cell Sci. 2020 Apr 21;134(5). pii: jcs.241752. doi: 10.1242/jcs.241752. PubMed |
| PIWIL4 Maintains HIV-1 Latency by Enforcing Epigenetically Suppressive Modifications on the 5' Long Terminal Repeat. He Z, Jing S, Yang T, Chen J, Huang F, Zhang W, Peng Z, Liu B, Ma X, Wu L, Pan T, Zhang X, Li L, Cai W, Tang X, Zhang J, Zhang H. J Virol. 2020 May 4;94(10). pii: JVI.01923-19. doi: 10.1128/JVI.01923-19. Print 2020 May 4. PubMed |
| High-Throughput, Temporal and Dose Dependent, Effect of Vitamins and Minerals on Chondrogenesis. Dennis JE, Splawn T, Kean TJ. Front Cell Dev Biol. 2020 Feb 25;8:92. doi: 10.3389/fcell.2020.00092. eCollection 2020. PubMed |
| [A Modified Lentivirus-Based Reporter for Magnetic Separation of Cancer Stem Cells]. Ivanova AE, Kravchenko DS, Chumakov SP. Mol Biol (Mosk). 2020 Jan-Feb;54(1):95-102. doi: 10.31857/S0026898419040049. PubMed |
A widespread family of heat-resistant obscure (Hero) proteins protect against protein instability and aggregation.
Tsuboyama K, Osaki T, Matsuura-Suzuki E, Kozuka-Hata H, Okada Y, Oyama M, Ikeuchi Y, Iwasaki S, Tomari Y.
PLoS Biol. 2020 Mar 12;18(3):e3000632. doi: 10.1371/journal.pbio.3000632. eCollection 2020 Mar.
PubMed
Associated Plasmids |
| Extracellular Redox Regulation of alpha7beta Integrin-Mediated Cell Migration Is Signaled via a Dominant Thiol-Switch. Bergerhausen L, Grosche J, Meissner J, Hecker C, Caliandro MF, Westerhausen C, Kamenac A, Rezaei M, Morgelin M, Poschmann G, Vestweber D, Hanschmann EM, Eble JA. Antioxidants (Basel). 2020 Mar 10;9(3). pii: antiox9030227. doi: 10.3390/antiox9030227. PubMed |
| Long noncoding RNA pncRNA-D reduces cyclin D1 gene expression and arrests cell cycle through RNA m(6)A modification. Yoneda R, Ueda N, Uranishi K, Hirasaki M, Kurokawa R. J Biol Chem. 2020 Apr 24;295(17):5626-5639. doi: 10.1074/jbc.RA119.011556. Epub 2020 Mar 12. PubMed |
| Genome editing of mutant KRAS through supramolecular polymer-mediated delivery of Cas9 ribonucleoprotein for colorectal cancer therapy. Wan T, Chen Y, Pan Q, Xu X, Kang Y, Gao X, Huang F, Wu C, Ping Y. J Control Release. 2020 Jun 10;322:236-247. doi: 10.1016/j.jconrel.2020.03.015. Epub 2020 Mar 10. PubMed |
| Proteasome inhibitors and Smac mimetics cooperate to induce cell death in diffuse large B-cell lymphoma by stabilizing NOXA and triggering mitochondrial apoptosis. Dietz A, Dalda N, Zielke S, Dittmann J, van Wijk SJL, Vogler M, Fulda S. Int J Cancer. 2020 Sep 1;147(5):1485-1498. doi: 10.1002/ijc.32976. Epub 2020 Apr 8. PubMed |
| Mechanical stretch induces myelin protein loss in oligodendrocytes by activating Erk1/2 in a calcium-dependent manner. Kim J, Adams AA, Gokina P, Zambrano B, Jayakumaran J, Dobrowolski R, Maurel P, Pfister BJ, Kim HA. Glia. 2020 Oct;68(10):2070-2085. doi: 10.1002/glia.23827. Epub 2020 Mar 14. PubMed |
| Detection of Lung Tumor Progression in Mice by Ultrasound Imaging. Ghaddar N, Wang S, Michaud V, Kazimierczak U, Ah-Son N, Koromilas AE. J Vis Exp. 2020 Feb 27;(156). doi: 10.3791/60565. PubMed |
| Biallelic loss of FAM46C triggers tumor growth with concomitant activation of Akt signaling in multiple myeloma cells. Kanasugi J, Hanamura I, Ota A, Karnan S, Lam VQ, Mizuno S, Wahiduzzaman M, Rahman ML, Hyodo T, Konishi H, Tsuzuki S, Hosokawa Y, Takami A. Cancer Sci. 2020 May;111(5):1663-1675. doi: 10.1111/cas.14386. Epub 2020 Apr 9. PubMed |
| An epilepsy-associated mutation in the nuclear import receptor KPNA7 reduces nuclear localization signal binding. Oostdyk LT, Wang Z, Zang C, Li H, McConnell MJ, Paschal BM. Sci Rep. 2020 Mar 16;10(1):4844. doi: 10.1038/s41598-020-61369-5. PubMed |
| Efficient production of a lentiviral system for displaying Crimean-Congo hemorrhagic fever virus glycoproteins reveals a broad range of cellular susceptibility and neutralization ability. Vasmehjani AA, Salehi-Vaziri M, Azadmanesh K, Nejati A, Pouriayevali MH, Gouya MM, Parsaeian M, Shahmahmoodi S. Arch Virol. 2020 May;165(5):1109-1120. doi: 10.1007/s00705-020-04576-9. Epub 2020 Mar 18. PubMed |
| Isoliquiritigenin Suppressed Esophageal Squamous Carcinoma Growth by Blocking EGFR Activation and Inducing Cell Cycle Arrest. Ye L, Zhang J, Zhang Y, Gu B, Zhu H, Mao X. Biomed Res Int. 2020 Mar 8;2020:9259852. doi: 10.1155/2020/9259852. eCollection 2020. PubMed |
| Scinderin suppresses cell proliferation and predicts the poor prognosis of hepatocellular carcinoma. Zhou B, Chen TW, Jiang YB, Wei XB, Lu CD, Li JJ, Xie D, Cheng SQ. Oncol Lett. 2020 Mar;19(3):2011-2020. doi: 10.3892/ol.2020.11262. Epub 2020 Jan 8. PubMed |
| LRP6-CRISPR prevents activation of hepatic stellate cells and liver fibrogenesis in rats. Yu L, Wang L, Yi H, Wu X. Am J Transl Res. 2020 Feb 15;12(2):397-408. eCollection 2020. PubMed |
| Girdin is a component of the lateral polarity protein network restricting cell dissemination. Biehler C, Wang LT, Sevigny M, Jette A, Gamblin CL, Catterall R, Houssin E, McCaffrey L, Laprise P. PLoS Genet. 2020 Mar 20;16(3):e1008674. doi: 10.1371/journal.pgen.1008674. eCollection 2020 Mar. PubMed |
| Derivation of porcine extraembryonic endoderm-like cells from blastocysts. Li Y, Wu S, Yu Y, Zhang H, Wei R, Lv J, Cai M, Yang X, Zhang Y, Liu Z. Cell Prolif. 2020 Apr;53(4):e12782. doi: 10.1111/cpr.12782. Epub 2020 Mar 20. PubMed |
| Deficiency of DICER reduces the invasion ability of trophoblasts and impairs the pro-angiogenic effect of trophoblast-derived microvesicles. Tang L, Yang M, Qin L, Li X, He G, Liu X, Xu W. J Cell Mol Med. 2020 May;24(9):4915-4930. doi: 10.1111/jcmm.14917. Epub 2020 Mar 21. PubMed |
| Long non-coding RNA GRASLND enhances chondrogenesis via suppression of the interferon type II signaling pathway. Huynh NP, Gloss CC, Lorentz J, Tang R, Brunger JM, McAlinden A, Zhang B, Guilak F. Elife. 2020 Mar 23;9. pii: 49558. doi: 10.7554/eLife.49558. PubMed |
| IL-23 signaling regulation of pro-inflammatory T-cell migration uncovered by phosphoproteomics. Alvarez-Salamero C, Castillo-Gonzalez R, Pastor-Fernandez G, Mariblanca IR, Pino J, Cibrian D, Navarro MN. PLoS Biol. 2020 Mar 23;18(3):e3000646. doi: 10.1371/journal.pbio.3000646. eCollection 2020 Mar. PubMed |
| Phosphorylated Lamin A/C in the Nuclear Interior Binds Active Enhancers Associated with Abnormal Transcription in Progeria. Ikegami K, Secchia S, Almakki O, Lieb JD, Moskowitz IP. Dev Cell. 2020 Mar 23;52(6):699-713.e11. doi: 10.1016/j.devcel.2020.02.011. PubMed |
| BRD4 inhibition exerts anti-viral activity through DNA damage-dependent innate immune responses. Wang J, Li GL, Ming SL, Wang CF, Shi LJ, Su BQ, Wu HT, Zeng L, Han YQ, Liu ZH, Jiang DW, Du YK, Li XD, Zhang GP, Yang GY, Chu BB. PLoS Pathog. 2020 Mar 24;16(3):e1008429. doi: 10.1371/journal.ppat.1008429. eCollection 2020 Mar. PubMed |
| CRISPR-based gene knockout screens reveal deubiquitinases involved in HIV-1 latency in two Jurkat cell models. Rathore A, Iketani S, Wang P, Jia M, Sahi V, Ho DD. Sci Rep. 2020 Mar 24;10(1):5350. doi: 10.1038/s41598-020-62375-3. PubMed |
| Nek2 kinase displaces distal appendages from the mother centriole prior to mitosis. Viol L, Hata S, Pastor-Peidro A, Neuner A, Murke F, Wuchter P, Ho AD, Giebel B, Pereira G. J Cell Biol. 2020 Mar 2;219(3). pii: 133805. doi: 10.1083/jcb.201907136. PubMed |
| Targeting clinical epigenetic reprogramming for chemoprevention of metabolic and viral hepatocellular carcinoma. Juhling F, Hamdane N, Crouchet E, Li S, El Saghire H, Mukherji A, Fujiwara N, Oudot MA, Thumann C, Saviano A, Roca Suarez AA, Goto K, Masia R, Sojoodi M, Arora G, Aikata H, Ono A, Tabrizian P, Schwartz M, Polyak SJ, Davidson I, Schmidl C, Bock C, Schuster C, Chayama K, Pessaux P, Tanabe KK, Hoshida Y, Zeisel MB, Duong FH, Fuchs BC, Baumert TF. Gut. 2021 Jan;70(1):157-169. doi: 10.1136/gutjnl-2019-318918. Epub 2020 Mar 26. PubMed |
| MiR-377-3p suppresses colorectal cancer through negative regulation on Wnt/beta-catenin signaling by targeting XIAP and ZEB2. Huang L, Liu Z, Hu J, Luo Z, Zhang C, Wang L, Wang Z. Pharmacol Res. 2020 Jun;156:104774. doi: 10.1016/j.phrs.2020.104774. Epub 2020 Mar 24. PubMed |
| mTORC2/Rac1 Pathway Predisposes Cancer Aggressiveness in IDH1-Mutated Glioma. Liu Y, Lu Y, Li A, Celiku O, Han S, Qian M, Yang C. Cancers (Basel). 2020 Mar 26;12(4). pii: cancers12040787. doi: 10.3390/cancers12040787. PubMed |
| MYC-Associated Factor MAX is a Regulator of the Circadian Clock. Blazevits O, Bolshette N, Vecchio D, Guijarro A, Croci O, Campaner S, Grimaldi B. Int J Mol Sci. 2020 Mar 26;21(7). pii: ijms21072294. doi: 10.3390/ijms21072294. PubMed |
| CIC is a critical regulator of neuronal differentiation. Hwang I, Pan H, Yao J, Elemento O, Zheng H, Paik J. JCI Insight. 2020 May 7;5(9). pii: 135826. doi: 10.1172/jci.insight.135826. PubMed |
| RNA helicase DDX21 mediates nucleotide stress responses in neural crest and melanoma cells. Santoriello C, Sporrij A, Yang S, Flynn RA, Henriques T, Dorjsuren B, Custo Greig E, McCall W, Stanhope ME, Fazio M, Superdock M, Lichtig A, Adatto I, Abraham BJ, Kalocsay M, Jurynec M, Zhou Y, Adelman K, Calo E, Zon LI. Nat Cell Biol. 2020 Apr;22(4):372-379. doi: 10.1038/s41556-020-0493-0. Epub 2020 Mar 30. PubMed |
| Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex. Minor MM, Hollinger FB, McNees AL, Jung SY, Jain A, Hyser JM, Bissig KD, Slagle BL. Cells. 2020 Mar 30;9(4). pii: cells9040834. doi: 10.3390/cells9040834. PubMed |
| Single-cell analysis of a mutant library generated using CRISPR-guided deaminase in human melanoma cells. Jun S, Lim H, Chun H, Lee JH, Bang D. Commun Biol. 2020 Apr 2;3(1):154. doi: 10.1038/s42003-020-0888-2. PubMed |
| (20S)G-Rh2 Inhibits NF-kappaB Regulated Epithelial-Mesenchymal Transition by Targeting Annexin A2. Wang YS, Li H, Li Y, Zhang S, Jin YH. Biomolecules. 2020 Mar 31;10(4). pii: biom10040528. doi: 10.3390/biom10040528. PubMed |
| Interaction between Epithelial Sodium Channel gamma-Subunit and Claudin-8 Modulates Paracellular Sodium Permeability in Renal Collecting Duct. Sassi A, Wang Y, Chassot A, Komarynets O, Roth I, Olivier V, Crambert G, Dizin E, Boscardin E, Hummler E, Feraille E. J Am Soc Nephrol. 2020 May;31(5):1009-1023. doi: 10.1681/ASN.2019080790. Epub 2020 Apr 3. PubMed |
| Hypoxic Regulation of Mitochondrial Metabolism and Mitophagy in Nucleus Pulposus Cells Is Dependent on HIF-1alpha-BNIP3 Axis. Madhu V, Boneski PK, Silagi E, Qiu Y, Kurland I, Guntur AR, Shapiro IM, Risbud MV. J Bone Miner Res. 2020 Aug;35(8):1504-1524. doi: 10.1002/jbmr.4019. Epub 2020 May 15. PubMed |
| PLX3397 treatment inhibits constitutive CSF1R-induced oncogenic ERK signaling, reduces tumor growth, and metastatic burden in osteosarcoma. Smeester BA, Slipek NJ, Pomeroy EJ, Laoharawee K, Osum SH, Larsson AT, Williams KB, Stratton N, Yamamoto K, Peterson JJ, Rathe SK, Mills LJ, Hudson WA, Crosby MR, Wang M, Rahrmann EP, Moriarity BS, Largaespada DA. Bone. 2020 Jul;136:115353. doi: 10.1016/j.bone.2020.115353. Epub 2020 Apr 3. PubMed |
| Mitochondrial DNA mutations induce mitochondrial biogenesis and increase the tumorigenic potential of Hodgkin and Reed-Sternberg cells. Haumann S, Boix J, Knuever J, Bieling A, Vila Sanjurjo A, Elson JL, Blakely EL, Taylor RW, Riet N, Abken H, Kashkar H, Hornig-Do HT, Wiesner RJ. Carcinogenesis. 2020 Apr 7. pii: 5817053. doi: 10.1093/carcin/bgaa032. PubMed |
| CX3CR1-CD8+ T cells are critical in antitumor efficacy but functionally suppressed in the tumor microenvironment. Yamauchi T, Hoki T, Oba T, Saito H, Attwood K, Sabel MS, Chang AE, Odunsi K, Ito F. JCI Insight. 2020 Apr 23;5(8). pii: 133920. doi: 10.1172/jci.insight.133920. PubMed |
| Roscovitine enhances all-trans retinoic acid (ATRA)-induced nuclear enrichment of an ensemble of activated signaling molecules and augments ATRA-induced myeloid cell differentiation. Rashid A, Duan X, Gao F, Yang M, Yen A. Oncotarget. 2020 Mar 24;11(12):1017-1036. doi: 10.18632/oncotarget.27508. eCollection 2020 Mar 24. PubMed |
| Sphingosine Kinase 1 Regulates the Survival of Breast Cancer Stem Cells and Non-stem Breast Cancer Cells by Suppression of STAT1. Hii LW, Chung FF, Mai CW, Yee ZY, Chan HH, Raja VJ, Dephoure NE, Pyne NJ, Pyne S, Leong CO. Cells. 2020 Apr 4;9(4). pii: cells9040886. doi: 10.3390/cells9040886. PubMed |
| Wireless optogenetics protects against obesity via stimulation of non-canonical fat thermogenesis. Tajima K, Ikeda K, Tanabe Y, Thomson EA, Yoneshiro T, Oguri Y, Ferro MD, Poon ASY, Kajimura S. Nat Commun. 2020 Apr 7;11(1):1730. doi: 10.1038/s41467-020-15589-y. PubMed |
| Electrospun Nanofiber Meshes With Endometrial MSCs Modulate Foreign Body Response by Increased Angiogenesis, Matrix Synthesis, and Anti-Inflammatory Gene Expression in Mice: Implication in Pelvic Floor. Mukherjee S, Darzi S, Paul K, Cousins FL, Werkmeister JA, Gargett CE. Front Pharmacol. 2020 Mar 24;11:353. doi: 10.3389/fphar.2020.00353. eCollection 2020. PubMed |
| Genome-wide CRISPR knockout screens identify ADAMTSL3 and PTEN genes as suppressors of HCC proliferation and metastasis, respectively. Zhou X, Li R, Jing R, Zuo B, Zheng Q. J Cancer Res Clin Oncol. 2020 Jun;146(6):1509-1521. doi: 10.1007/s00432-020-03207-9. Epub 2020 Apr 7. PubMed |
| Genome-wide Screens Implicate Loss of Cullin Ring Ligase 3 in Persistent Proliferation and Genome Instability in TP53-Deficient Cells. Drainas AP, Lambuta RA, Ivanova I, Sercin O, Sarropoulos I, Smith ML, Efthymiopoulos T, Raeder B, Stutz AM, Waszak SM, Mardin BR, Korbel JO. Cell Rep. 2020 Apr 7;31(1):107465. doi: 10.1016/j.celrep.2020.03.029. PubMed |
| Trophectoderm-Specific Knockdown of LIN28 Decreases Expression of Genes Necessary for Cell Proliferation and Reduces Elongation of Sheep Conceptus. Ali A, Stenglein MD, Spencer TE, Bouma GJ, Anthony RV, Winger QA. Int J Mol Sci. 2020 Apr 6;21(7). pii: ijms21072549. doi: 10.3390/ijms21072549. PubMed |
| Gain-of-Function Genetic Alterations of G9a Drive Oncogenesis. Kato S, Weng QY, Insco ML, Chen KY, Muralidhar S, Pozniak J, Diaz JMS, Drier Y, Nguyen N, Lo JA, van Rooijen E, Kemeny LV, Zhan Y, Feng Y, Silkworth W, Powell CT, Liau BB, Xiong Y, Jin J, Newton-Bishop J, Zon LI, Bernstein BE, Fisher DE. Cancer Discov. 2020 Jul;10(7):980-997. doi: 10.1158/2159-8290.CD-19-0532. Epub 2020 Apr 8. PubMed |
| ADAMTS-1 and syndecan-4 intersect in the regulation of cell migration and angiogenesis. Lambert J, Makin K, Akbareian S, Johnson R, Alghamdi AAA, Robinson SD, Edwards DR. J Cell Sci. 2020 Apr 8;133(7). pii: jcs.235762. doi: 10.1242/jcs.235762. PubMed |
| KDM6A-Mediated Expression of the Long Noncoding RNA DINO Causes TP53 Tumor Suppressor Stabilization in Human Papillomavirus 16 E7-Expressing Cells. Sharma S, Munger K. J Virol. 2020 Jun 1;94(12). pii: JVI.02178-19. doi: 10.1128/JVI.02178-19. Print 2020 Jun 1. PubMed |
| Complement-Independent Modulation of Influenza A Virus Infection by Factor H. Murugaiah V, Varghese PM, Saleh SM, Tsolaki AG, Alrokayan SH, Khan HA, Collison KS, Sim RB, Nal B, Al-Mohanna FA, Kishore U. Front Immunol. 2020 Mar 25;11:355. doi: 10.3389/fimmu.2020.00355. eCollection 2020. PubMed |
| A Humanized Lym-1 CAR with Novel DAP10/DAP12 Signaling Domains Demonstrates Reduced Tonic Signaling and Increased Antitumor Activity in B-Cell Lymphoma Models. Zheng L, Ren L, Kouhi A, Khawli LA, Hu P, Kaslow HR, Epstein AL. Clin Cancer Res. 2020 Jul 15;26(14):3694-3706. doi: 10.1158/1078-0432.CCR-19-3417. Epub 2020 Apr 9. PubMed |
| Phenotype instability of hepatocyte-like cells produced by direct reprogramming of mesenchymal stromal cells. Orge ID, Gadd VL, Barouh JL, Rossi EA, Carvalho RH, Smith I, Allahdadi KJ, Paredes BD, Silva DN, Damasceno PKF, Sampaio GL, Forbes SJ, Soares MBP, Souza BSF. Stem Cell Res Ther. 2020 Apr 10;11(1):154. doi: 10.1186/s13287-020-01665-z. PubMed |
| miR-206 family is important for mitochondrial and muscle function, but not essential for myogenesis in vitro. Przanowska RK, Sobierajska E, Su Z, Jensen K, Przanowski P, Nagdas S, Kashatus JA, Kashatus DF, Bhatnagar S, Lukens JR, Dutta A. FASEB J. 2020 Jun;34(6):7687-7702. doi: 10.1096/fj.201902855RR. Epub 2020 Apr 11. PubMed |
| Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter. Xiao Y, Lamar JM. J Vis Exp. 2020 Mar 27;(157). doi: 10.3791/60582. PubMed |
| TRIM34 restricts HIV-1 and SIV capsids in a TRIM5alpha-dependent manner. Ohainle M, Kim K, Komurlu Keceli S, Felton A, Campbell E, Luban J, Emerman M. PLoS Pathog. 2020 Apr 13;16(4):e1008507. doi: 10.1371/journal.ppat.1008507. eCollection 2020 Apr. PubMed |
| Dissecting the novel partners of nuclear c-Raf and its role in all-trans retinoic acid (ATRA)-induced myeloblastic leukemia cells differentiation. Rashid A, Wang R, Zhang L, Yue J, Yang M, Yen A. Exp Cell Res. 2020 Sep 1;394(1):111989. doi: 10.1016/j.yexcr.2020.111989. Epub 2020 Apr 10. PubMed |
| Merkel cell polyomavirus activates LSD1-mediated blockade of non-canonical BAF to regulate transformation and tumorigenesis. Park DE, Cheng J, McGrath JP, Lim MY, Cushman C, Swanson SK, Tillgren ML, Paulo JA, Gokhale PC, Florens L, Washburn MP, Trojer P, DeCaprio JA. Nat Cell Biol. 2020 May;22(5):603-615. doi: 10.1038/s41556-020-0503-2. Epub 2020 Apr 13. PubMed |
| Identification of tumorigenicity-associated genes in osteosarcoma cell lines based on bioinformatic analysis and experimental validation. Jiang S, Zhou F, Zhang Y, Zhou W, Zhu L, Zhang M, Luo J, Ma R, Xu X, Zhu J, Dong X, Zhang S, Fang J, Sun J, Yang X. J Cancer. 2020 Mar 26;11(12):3623-3633. doi: 10.7150/jca.37393. eCollection 2020. PubMed |
| A Probabilistic Classification Tool for Genetic Subtypes of Diffuse Large B Cell Lymphoma with Therapeutic Implications. Wright GW, Huang DW, Phelan JD, Coulibaly ZA, Roulland S, Young RM, Wang JQ, Schmitz R, Morin RD, Tang J, Jiang A, Bagaev A, Plotnikova O, Kotlov N, Johnson CA, Wilson WH, Scott DW, Staudt LM. Cancer Cell. 2020 Apr 13;37(4):551-568.e14. doi: 10.1016/j.ccell.2020.03.015. PubMed |
| Human cytomegalovirus long noncoding RNA4.9 regulates viral DNA replication. Tai-Schmiedel J, Karniely S, Lau B, Ezra A, Eliyahu E, Nachshon A, Kerr K, Suarez N, Schwartz M, Davison AJ, Stern-Ginossar N. PLoS Pathog. 2020 Apr 15;16(4):e1008390. doi: 10.1371/journal.ppat.1008390. eCollection 2020 Apr. PubMed |
| Hotspots of Aberrant Enhancer Activity in Fibrolamellar Carcinoma Reveal Candidate Oncogenic Pathways and Therapeutic Vulnerabilities. Dinh TA, Sritharan R, Smith FD, Francisco AB, Ma RK, Bunaciu RP, Kanke M, Danko CG, Massa AP, Scott JD, Sethupathy P. Cell Rep. 2020 Apr 14;31(2):107509. doi: 10.1016/j.celrep.2020.03.073. PubMed |
| Inhibition of CDK9 by voruciclib synergistically enhances cell death induced by the Bcl-2 selective inhibitor venetoclax in preclinical models of acute myeloid leukemia. Luedtke DA, Su Y, Ma J, Li X, Buck SA, Edwards H, Polin L, Kushner J, Dzinic SH, White K, Lin H, Taub JW, Ge Y. Signal Transduct Target Ther. 2020 Feb 26;5(1):17. doi: 10.1038/s41392-020-0112-3. PubMed |
| A high-content RNAi screen reveals multiple roles for long noncoding RNAs in cell division. Stojic L, Lun ATL, Mascalchi P, Ernst C, Redmond AM, Mangei J, Barr AR, Bousgouni V, Bakal C, Marioni JC, Odom DT, Gergely F. Nat Commun. 2020 Apr 15;11(1):1851. doi: 10.1038/s41467-020-14978-7. PubMed |
| Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense. Zheng M, Karki R, Vogel P, Kanneganti TD. Cell. 2020 Apr 30;181(3):674-687.e13. doi: 10.1016/j.cell.2020.03.040. Epub 2020 Apr 15. PubMed |
| GATA3 Mediates a Fast, Irreversible Commitment to BMP4-Driven Differentiation in Human Embryonic Stem Cells. Gunne-Braden A, Sullivan A, Gharibi B, Sheriff RSM, Maity A, Wang YF, Edwards A, Jiang M, Howell M, Goldstone R, Wollman R, East P, Santos SDM. Cell Stem Cell. 2020 May 7;26(5):693-706.e9. doi: 10.1016/j.stem.2020.03.005. Epub 2020 Apr 16. PubMed |
| HMCES safeguards replication from oxidative stress and ensures error-free repair. Srivastava M, Su D, Zhang H, Chen Z, Tang M, Nie L, Chen J. EMBO Rep. 2020 Jun 4;21(6):e49123. doi: 10.15252/embr.201949123. Epub 2020 Apr 19. PubMed |
| Selective targeting of the oncogenic KRAS G12S mutant allele by CRISPR/Cas9 induces efficient tumor regression. Gao Q, Ouyang W, Kang B, Han X, Xiong Y, Ding R, Li Y, Wang F, Huang L, Chen L, Wang D, Dong X, Zhang Z, Li Y, Ze B, Hou Y, Yang H, Ma Y, Gu Y, Chao CC. Theranostics. 2020 Apr 6;10(11):5137-5153. doi: 10.7150/thno.42325. eCollection 2020. PubMed |
| A-kinase anchoring protein 8L interacts with mTORC1 and promotes cell growth. Melick CH, Meng D, Jewell JL. J Biol Chem. 2020 Jun 5;295(23):8096-8105. doi: 10.1074/jbc.AC120.012595. Epub 2020 Apr 20. PubMed |
| Allosteric Activators of Protein Phosphatase 2A Display Broad Antitumor Activity Mediated by Dephosphorylation of MYBL2. Morita K, He S, Nowak RP, Wang J, Zimmerman MW, Fu C, Durbin AD, Martel MW, Prutsch N, Gray NS, Fischer ES, Look AT. Cell. 2020 Apr 30;181(3):702-715.e20. doi: 10.1016/j.cell.2020.03.051. Epub 2020 Apr 20. PubMed |
| Impact of IFN-beta and LIF overexpression on human adipose-derived stem cells properties. Ashja-Arvan M, Dehbashi M, Eslami A, Salehi H, Yoosefi M, Ganjalikhani-Hakemi M. J Cell Physiol. 2020 Apr 23. doi: 10.1002/jcp.29717. PubMed |
| Zikavirus prME Envelope Pseudotyped Human Immunodeficiency Virus Type-1 as a Novel Tool for Glioblastoma-Directed Virotherapy. Kretschmer M, Kadlubowska P, Hoffmann D, Schwalbe B, Auerswald H, Schreiber M. Cancers (Basel). 2020 Apr 18;12(4). pii: cancers12041000. doi: 10.3390/cancers12041000. PubMed |
Multiplex T Cell Stimulation Assay Utilizing a T Cell Activation Reporter-Based Detection System.
Mann SE, Zhou Z, Landry LG, Anderson AM, Alkanani AK, Fischer J, Peakman M, Mallone R, Campbell K, Michels AW, Nakayama M.
Front Immunol. 2020 Apr 9;11:633. doi: 10.3389/fimmu.2020.00633. eCollection 2020.
PubMed
Associated Plasmids |
| Myogenic Progenitor Cell Lineage Specification by CRISPR/Cas9-Based Transcriptional Activators. Kwon JB, Vankara A, Ettyreddy AR, Bohning JD, Gersbach CA. Stem Cell Reports. 2020 May 12;14(5):755-769. doi: 10.1016/j.stemcr.2020.03.026. Epub 2020 Apr 23. PubMed |
| Absolute Quantification of Transcription Factors Reveals Principles of Gene Regulation in Erythropoiesis. Gillespie MA, Palii CG, Sanchez-Taltavull D, Shannon P, Longabaugh WJR, Downes DJ, Sivaraman K, Espinoza HM, Hughes JR, Price ND, Perkins TJ, Ranish JA, Brand M. Mol Cell. 2020 Jun 4;78(5):960-974.e11. doi: 10.1016/j.molcel.2020.03.031. Epub 2020 Apr 23. PubMed |
| Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity. He Y, Zhang X, Chang J, Kim HN, Zhang P, Wang Y, Khan S, Liu X, Zhang X, Lv D, Song L, Li W, Thummuri D, Yuan Y, Wiegand JS, Ortiz YT, Budamagunta V, Elisseeff JH, Campisi J, Almeida M, Zheng G, Zhou D. Nat Commun. 2020 Apr 24;11(1):1996. doi: 10.1038/s41467-020-15838-0. PubMed |
| Non-coding somatic mutations converge on the PAX8 pathway in ovarian cancer. Corona RI, Seo JH, Lin X, Hazelett DJ, Reddy J, Fonseca MAS, Abassi F, Lin YG, Mhawech-Fauceglia PY, Shah SP, Huntsman DG, Gusev A, Karlan BY, Berman BP, Freedman ML, Gayther SA, Lawrenson K. Nat Commun. 2020 Apr 24;11(1):2020. doi: 10.1038/s41467-020-15951-0. PubMed |
Selective alanine transporter utilization creates a targetable metabolic niche in pancreatic cancer.
Parker SJ, Amendola CR, Hollinshead KER, Yu Q, Yamamoto K, Encarnacion-Rosado J, Rose RE, LaRue MM, Sohn ASW, Biancur DE, Paulo JA, Gygi SP, Jones DR, Wang H, Philips MR, Bar-Sagi D, Mancias JD, Kimmelman AC.
Cancer Discov. 2020 Apr 27. pii: 2159-8290.CD-19-0959. doi: 10.1158/2159-8290.CD-19-0959.
PubMed
Associated Plasmids |
| Aging-regulated anti-apoptotic long non-coding RNA Sarrah augments recovery from acute myocardial infarction. Trembinski DJ, Bink DI, Theodorou K, Sommer J, Fischer A, van Bergen A, Kuo CC, Costa IG, Schurmann C, Leisegang MS, Brandes RP, Alekseeva T, Brill B, Wietelmann A, Johnson CN, Spring-Connell A, Kaulich M, Werfel S, Engelhardt S, Hirt MN, Yorgan K, Eschenhagen T, Kirchhof L, Hofmann P, Jae N, Wittig I, Hamdani N, Bischof C, Krishnan J, Houtkooper RH, Dimmeler S, Boon RA. Nat Commun. 2020 Apr 27;11(1):2039. doi: 10.1038/s41467-020-15995-2. PubMed |
| Decrease in SHP-1 enhances myometrium remodeling via FAK activation leading to labor. Chen HY, Gao LT, Yuan JQ, Zhang YJ, Liu P, Wang G, Ni X, Liu WN, Gao L. Am J Physiol Endocrinol Metab. 2020 Jun 1;318(6):E930-E942. doi: 10.1152/ajpendo.00068.2020. Epub 2020 Apr 28. PubMed |
| GRAF2, WDR44, and MICAL1 mediate Rab8/10/11-dependent export of E-cadherin, MMP14, and CFTR DeltaF508. Lucken-Ardjomande Hasler S, Vallis Y, Pasche M, McMahon HT. J Cell Biol. 2020 May 4;219(5). pii: 151714. doi: 10.1083/jcb.201811014. PubMed |
| lncRNA Neat1 Stimulates Osteoclastogenesis Via Sponging miR-7. Zhang Y, Chen XF, Li J, He F, Li X, Guo Y. J Bone Miner Res. 2020 Apr 30. doi: 10.1002/jbmr.4039. PubMed |
| A novel neurodegenerative spectrum disorder in patients with MLKL deficiency. Faergeman SL, Evans H, Attfield KE, Desel C, Kuttikkatte SB, Sommerlund M, Jensen LT, Frokiaer J, Friese MA, Matthews PM, Luchtenborg C, Brugger B, Oturai AB, Dendrou CA, Fugger L. Cell Death Dis. 2020 May 1;11(5):303. doi: 10.1038/s41419-020-2494-0. PubMed |
| FADD and Caspase-8 Regulate Gut Homeostasis and Inflammation by Controlling MLKL- and GSDMD-Mediated Death of Intestinal Epithelial Cells. Schwarzer R, Jiao H, Wachsmuth L, Tresch A, Pasparakis M. Immunity. 2020 Jun 16;52(6):978-993.e6. doi: 10.1016/j.immuni.2020.04.002. Epub 2020 May 1. PubMed |
| Treatment of cancer cells with Lapatinib negatively regulates general translation and induces stress granules formation. Adjibade P, Simoneau B, Ledoux N, Gauthier WN, Nkurunziza M, Khandjian EW, Mazroui R. PLoS One. 2020 May 4;15(5):e0231894. doi: 10.1371/journal.pone.0231894. eCollection 2020. PubMed |
| TRAF3IP3 negatively regulates cytosolic RNA induced anti-viral signaling by promoting TBK1 K48 ubiquitination. Deng M, Tam JW, Wang L, Liang K, Li S, Zhang L, Guo H, Luo X, Zhang Y, Petrucelli A, Davis BK, Conti BJ, June Brickey W, Ko CC, Lei YL, Sun S, Ting JP. Nat Commun. 2020 May 4;11(1):2193. doi: 10.1038/s41467-020-16014-0. PubMed |
| Formate induces a metabolic switch in nucleotide and energy metabolism. Oizel K, Tait-Mulder J, Fernandez-de-Cossio-Diaz J, Pietzke M, Brunton H, Lilla S, Dhayade S, Athineos D, Blanco GR, Sumpton D, Mackay GM, Blyth K, Zanivan SR, Meiser J, Vazquez A. Cell Death Dis. 2020 May 4;11(5):310. doi: 10.1038/s41419-020-2523-z. PubMed |
| The Robust Restriction of Zika Virus by Type-I Interferon in A549 Cells Varies by Viral Lineage and Is Not Determined by IFITM3. Gobillot TA, Humes D, Sharma A, Kikawa C, Overbaugh J. Viruses. 2020 May 2;12(5). pii: v12050503. doi: 10.3390/v12050503. PubMed |
| Expression and function of voltage gated proton channels (Hv1) in MDA-MB-231 cells. Bare DJ, Cherny VV, DeCoursey TE, Abukhdeir AM, Morgan D. PLoS One. 2020 May 6;15(5):e0227522. doi: 10.1371/journal.pone.0227522. eCollection 2020. PubMed |
| An Alternative Splicing of Tupaia STING Modulated Anti-RNA Virus Responses by Targeting MDA5-LGP2 and IRF3. Xu L, Yu D, Peng L, Wu Y, Fan Y, Gu T, Yao YL, Zhong J, Chen X, Yao YG. J Immunol. 2020 Jun 15;204(12):3191-3204. doi: 10.4049/jimmunol.1901320. Epub 2020 May 6. PubMed |
Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I.
Yamamoto K, Venida A, Yano J, Biancur DE, Kakiuchi M, Gupta S, Sohn ASW, Mukhopadhyay S, Lin EY, Parker SJ, Banh RS, Paulo JA, Wen KW, Debnath J, Kim GE, Mancias JD, Fearon DT, Perera RM, Kimmelman AC.
Nature. 2020 May;581(7806):100-105. doi: 10.1038/s41586-020-2229-5. Epub 2020 Apr 22.
PubMed
Associated Plasmids |
| Porcine DNAJB6 promotes PCV2 replication via enhancing the formation of autophagy in host cells. Han C, Du Q, Zhu L, Chen N, Luo L, Chen Q, Yin J, Wu X, Tong D, Huang Y. Vet Res. 2020 May 7;51(1):61. doi: 10.1186/s13567-020-00783-z. PubMed |
| Efficient Generation and Correction of Mutations in Human iPS Cells Utilizing mRNAs of CRISPR Base Editors and Prime Editors. Surun D, Schneider A, Mircetic J, Neumann K, Lansing F, Paszkowski-Rogacz M, Hanchen V, Lee-Kirsch MA, Buchholz F. Genes (Basel). 2020 May 6;11(5). pii: genes11050511. doi: 10.3390/genes11050511. PubMed |
| Biochemical characteristics of the chondrocyte-enriched SNORC protein and its transcriptional regulation by SOX9. Jaiswal PK, Aljebali L, Gaumond MH, Oh CD, Yasuda H, Moffatt P. Sci Rep. 2020 May 8;10(1):7790. doi: 10.1038/s41598-020-64640-x. PubMed |
| Targeted Degradation of SLC Transporters Reveals Amenability of Multi-Pass Transmembrane Proteins to Ligand-Induced Proteolysis. Bensimon A, Pizzagalli MD, Kartnig F, Dvorak V, Essletzbichler P, Winter GE, Superti-Furga G. Cell Chem Biol. 2020 Jun 18;27(6):728-739.e9. doi: 10.1016/j.chembiol.2020.04.003. Epub 2020 May 7. PubMed |
| Blocking interaction between SHP2 and PD-1 denotes a novel opportunity for developing PD-1 inhibitors. Fan Z, Tian Y, Chen Z, Liu L, Zhou Q, He J, Coleman J, Dong C, Li N, Huang J, Xu C, Zhang Z, Gao S, Zhou P, Ding K, Chen L. EMBO Mol Med. 2020 Jun 8;12(6):e11571. doi: 10.15252/emmm.201911571. Epub 2020 May 11. PubMed |
| NFI transcription factors provide chromatin access to maintain stem cell identity while preventing unintended lineage fate choices. Adam RC, Yang H, Ge Y, Infarinato NR, Gur-Cohen S, Miao Y, Wang P, Zhao Y, Lu CP, Kim JE, Ko JY, Paik SS, Gronostajski RM, Kim J, Krueger JG, Zheng D, Fuchs E. Nat Cell Biol. 2020 Jun;22(6):640-650. doi: 10.1038/s41556-020-0513-0. Epub 2020 May 11. PubMed |
| Tob2 phosphorylation regulates global mRNA turnover to reshape transcriptome and impact cell proliferation. Chen CA, Strouz K, Huang KL, Shyu AB. RNA. 2020 Sep;26(9):1143-1159. doi: 10.1261/rna.073528.119. Epub 2020 May 13. PubMed |
| The mRNA Cap 2'-O-Methyltransferase CMTR1 Regulates the Expression of Certain Interferon-Stimulated Genes. Williams GD, Gokhale NS, Snider DL, Horner SM. mSphere. 2020 May 13;5(3). pii: 5/3/e00202-20. doi: 10.1128/mSphere.00202-20. PubMed |
| Patient fibroblast circadian rhythms predict lithium sensitivity in bipolar disorder. Sanghani HR, Jagannath A, Humberstone T, Ebrahimjee F, Thomas JM, Churchill GC, Cipriani A, Attenburrow MJ, Perestenko OV, Cowley SA, Cader MZ, Peirson SN, Harrison PJ, Foster RG, Goodwin GM, Vasudevan SR. Mol Psychiatry. 2020 May 13. pii: 10.1038/s41380-020-0769-6. doi: 10.1038/s41380-020-0769-6. PubMed |
High-affinity mutant Interleukin-13 targeted CAR T cells enhance delivery of clickable biodegradable fluorescent nanoparticles to glioblastoma.
Kim GB, Aragon-Sanabria V, Randolph L, Jiang H, Reynolds JA, Webb BS, Madhankumar A, Lian X, Connor JR, Yang J, Dong C.
Bioact Mater. 2020 May 7;5(3):624-635. doi: 10.1016/j.bioactmat.2020.04.011. eCollection 2020 Sep.
PubMed
Associated Plasmids |
| Laminin-511 and alpha6 integrins regulate the expression of CXCR4 to promote endothelial morphogenesis. Xu H, Pumiglia K, LaFlamme SE. J Cell Sci. 2020 Jun 11;133(11). pii: jcs.246595. doi: 10.1242/jcs.246595. PubMed |
| Auxiliary alpha2delta1 and alpha2delta3 Subunits of Calcium Channels Drive Excitatory and Inhibitory Neuronal Network Development. Bikbaev A, Ciuraszkiewicz-Wojciech A, Heck J, Klatt O, Freund R, Mitlohner J, Enrile Lacalle S, Sun M, Repetto D, Frischknecht R, Ablinger C, Rohlmann A, Missler M, Obermair GJ, Di Biase V, Heine M. J Neurosci. 2020 Jun 17;40(25):4824-4841. doi: 10.1523/JNEUROSCI.1707-19.2020. Epub 2020 May 15. PubMed |
| Molecular profiling reveals a hypoxia signature in breast implant-associated anaplastic large cell lymphoma. Oishi N, Hundal T, Phillips JL, Dasari S, Hu G, Viswanatha DS, He R, Mai M, Jacobs HK, Ahmed NH, Syrbu SI, Salama Y, Chapman JR, Vega F, Sidhu J, Bennani NN, Epstein AL, Medeiros LJ, Clemens MW, Miranda RN, Feldman AL. Haematologica. 2020 May 15. pii: haematol.2019.245860. doi: 10.3324/haematol.2019.245860. PubMed |
| Procedures for Culturing and Genetically Manipulating Murine Hippocampal Postnatal Neurons. Moutin E, Hemonnot AL, Seube V, Linck N, Rassendren F, Perroy J, Compan V. Front Synaptic Neurosci. 2020 Apr 30;12:19. doi: 10.3389/fnsyn.2020.00019. eCollection 2020. PubMed |
| ZKSCAN3 counteracts cellular senescence by stabilizing heterochromatin. Hu H, Ji Q, Song M, Ren J, Liu Z, Wang Z, Liu X, Yan K, Hu J, Jing Y, Wang S, Zhang W, Liu GH, Qu J. Nucleic Acids Res. 2020 Jun 19;48(11):6001-6018. doi: 10.1093/nar/gkaa425. PubMed |
| Stress-induced TRAILR2 expression overcomes TRAIL resistance in cancer cell spheroids. Stohr D, Schmid JO, Beigl TB, Mack A, Maichl DS, Cao K, Budai B, Fullstone G, Kontermann RE, Murdter TE, Tait SWG, Hagenlocher C, Pollak N, Scheurich P, Rehm M. Cell Death Differ. 2020 May 20. pii: 10.1038/s41418-020-0559-3. doi: 10.1038/s41418-020-0559-3. PubMed |
| Enterovirus 71 induces neural cell apoptosis and autophagy through promoting ACOX1 downregulation and ROS generation. You L, Chen J, Liu W, Xiang Q, Luo Z, Wang W, Xu W, Wu K, Zhang Q, Liu Y, Wu J. Virulence. 2020 Dec;11(1):537-553. doi: 10.1080/21505594.2020.1766790. PubMed |
| IDO1(+) Paneth cells promote immune escape of colorectal cancer. Pflugler S, Svinka J, Scharf I, Crncec I, Filipits M, Charoentong P, Tschurtschenthaler M, Kenner L, Awad M, Stift J, Schernthanner M, Bischl R, Herndler-Brandstetter D, Glitzner E, Moll HP, Casanova E, Timelthaler G, Sibilia M, Gnant M, Lax S, Thaler J, Muller M, Strobl B, Mohr T, Kaser A, Trajanoski Z, Heller G, Eferl R. Commun Biol. 2020 May 22;3(1):252. doi: 10.1038/s42003-020-0989-y. PubMed |
| Nucleoporin 153 links nuclear pore complex to chromatin architecture by mediating CTCF and cohesin binding. Kadota S, Ou J, Shi Y, Lee JT, Sun J, Yildirim E. Nat Commun. 2020 May 25;11(1):2606. doi: 10.1038/s41467-020-16394-3. PubMed |
| Gangliosides are essential endosomal receptors for quasi-enveloped and naked hepatitis A virus. Das A, Barrientos R, Shiota T, Madigan V, Misumi I, McKnight KL, Sun L, Li Z, Meganck RM, Li Y, Kaluzna E, Asokan A, Whitmire JK, Kapustina M, Zhang Q, Lemon SM. Nat Microbiol. 2020 Sep;5(9):1069-1078. doi: 10.1038/s41564-020-0727-8. Epub 2020 May 25. PubMed |
| Ecto-NTPDase CD39 is a negative checkpoint that inhibits follicular helper cell generation. Cao W, Fang F, Gould T, Li X, Kim C, Gustafson C, Lambert S, Weyand CM, Goronzy JJ. J Clin Invest. 2020 Jul 1;130(7):3422-3436. doi: 10.1172/JCI132417. PubMed |
| DNA damage invokes mitophagy through a pathway involving Spata18. Dan X, Babbar M, Moore A, Wechter N, Tian J, Mohanty JG, Croteau DL, Bohr VA. Nucleic Acids Res. 2020 Jul 9;48(12):6611-6623. doi: 10.1093/nar/gkaa393. PubMed |
| Lentivirally administered glial cell line-derived neurotrophic factor promotes post-ischemic neurological recovery, brain remodeling and contralesional pyramidal tract plasticity by regulating axonal growth inhibitors and guidance proteins. Beker M, Caglayan AB, Beker MC, Altunay S, Karacay R, Dalay A, Altintas MO, Kose GT, Hermann DM, Kilic E. Exp Neurol. 2020 May 23;331:113364. doi: 10.1016/j.expneurol.2020.113364. PubMed |
| An Integrated Genomic Strategy to Identify CHRNB4 as a Diagnostic/Prognostic Biomarker for Targeted Therapy in Head and Neck Cancer. Chuang YH, Lee CH, Lin CY, Liu CL, Huang SH, Lee JY, Chiu YY, Lee JC, Yang JM. Cancers (Basel). 2020 May 22;12(5). pii: cancers12051324. doi: 10.3390/cancers12051324. PubMed |
| SIX2 Regulates Human beta Cell Differentiation from Stem Cells and Functional Maturation In Vitro. Velazco-Cruz L, Goedegebuure MM, Maxwell KG, Augsornworawat P, Hogrebe NJ, Millman JR. Cell Rep. 2020 May 26;31(8):107687. doi: 10.1016/j.celrep.2020.107687. PubMed |
| Increased expression of miR142 and miR155 in glial and immune cells after traumatic brain injury may contribute to neuroinflammation via astrocyte activation. Korotkov A, Puhakka N, Gupta SD, Vuokila N, Broekaart DWM, Anink JJ, Heiskanen M, Karttunen J, van Scheppingen J, Huitinga I, Mills JD, van Vliet EA, Pitkanen A, Aronica E. Brain Pathol. 2020 May 27. doi: 10.1111/bpa.12865. PubMed |
| MESH1 is a cytosolic NADPH phosphatase that regulates ferroptosis. Ding CC, Rose J, Sun T, Wu J, Chen PH, Lin CC, Yang WH, Chen KY, Lee H, Xu E, Tian S, Akinwuntan J, Zhao J, Guan Z, Zhou P, Chi JT. Nat Metab. 2020 Mar;2(3):270-277. doi: 10.1038/s42255-020-0181-1. Epub 2020 Mar 9. PubMed |
| Establishment of stable Vero cell lines expressing TMPRSS2 and MSPL: A useful tool for propagating porcine epidemic diarrhea virus in the absence of exogenous trypsin. Wang X, Qiao X, Sui L, Zhao H, Li F, Tang YD, Shi W, Guo Y, Jiang Y, Wang L, Zhou H, Tang L, Xu Y, Li Y. Virulence. 2020 Dec;11(1):669-685. doi: 10.1080/21505594.2020.1770491. PubMed |
| miR-486 is involved in the pathogenesis of acute myeloid leukemia by regulating JAK-STAT signaling. Sha C, Jia G, Jingjing Z, Yapeng H, Zhi L, Guanghui X. Naunyn Schmiedebergs Arch Pharmacol. 2020 May 29. pii: 10.1007/s00210-020-01892-4. doi: 10.1007/s00210-020-01892-4. PubMed |
| Chemical modulation of circadian rhythms and assessment of cellular behavior via indirubin and derivatives. Lin HH, Robertson KL, Lellupitiyage Don SS, Taylor SR, Farkas ME. Methods Enzymol. 2020;639:115-140. doi: 10.1016/bs.mie.2020.04.011. Epub 2020 Apr 30. PubMed |
| CAMK2A supported tumor initiating cells of lung adenocarcinoma by upregulating SOX2 through EZH2 phosphorylation. Wang SQ, Liu J, Qin J, Zhu Y, Tin VP, Yam JWP, Wong MP, Xiao ZJ. Cell Death Dis. 2020 Jun 1;11(6):410. doi: 10.1038/s41419-020-2553-6. PubMed |
| Targeted Perturb-seq enables genome-scale genetic screens in single cells. Schraivogel D, Gschwind AR, Milbank JH, Leonce DR, Jakob P, Mathur L, Korbel JO, Merten CA, Velten L, Steinmetz LM. Nat Methods. 2020 Jun;17(6):629-635. doi: 10.1038/s41592-020-0837-5. Epub 2020 Jun 1. PubMed |
Base editors for simultaneous introduction of C-to-T and A-to-G mutations.
Sakata RC, Ishiguro S, Mori H, Tanaka M, Tatsuno K, Ueda H, Yamamoto S, Seki M, Masuyama N, Nishida K, Nishimasu H, Arakawa K, Kondo A, Nureki O, Tomita M, Aburatani H, Yachie N.
Nat Biotechnol. 2020 Jun 1. pii: 10.1038/s41587-020-0509-0. doi: 10.1038/s41587-020-0509-0.
PubMed
Associated Plasmids |
| Identification of a potent and selective covalent Pin1 inhibitor. Pinch BJ, Doctor ZM, Nabet B, Browne CM, Seo HS, Mohardt ML, Kozono S, Lian X, Manz TD, Chun Y, Kibe S, Zaidman D, Daitchman D, Yeoh ZC, Vangos NE, Geffken EA, Tan L, Ficarro SB, London N, Marto JA, Buratowski S, Dhe-Paganon S, Zhou XZ, Lu KP, Gray NS. Nat Chem Biol. 2020 Sep;16(9):979-987. doi: 10.1038/s41589-020-0550-9. Epub 2020 Jun 1. PubMed |
| ABL Genomic Editing Sufficiently Abolishes Oncogenesis of Human Chronic Myeloid Leukemia Cells In Vitro and In Vivo. Chen SH, Hsieh YY, Tzeng HE, Lin CY, Hsu KW, Chiang YS, Lin SM, Su MJ, Hsieh WS, Lee CH. Cancers (Basel). 2020 May 29;12(6). pii: cancers12061399. doi: 10.3390/cancers12061399. PubMed |
| Expression profiles and function of IL6 in polymorphonuclear myeloid-derived suppressor cells. Ibrahim ML, Lu C, Klement JD, Redd PS, Yang D, Smith AD, Liu K. Cancer Immunol Immunother. 2020 Jun 1. pii: 10.1007/s00262-020-02620-w. doi: 10.1007/s00262-020-02620-w. PubMed |
| Filoviruses Use the HOPS Complex and UVRAG To Traffic to Niemann-Pick C1 Compartments during Viral Entry. Bo Y, Qiu S, Mulloy RP, Cote M. J Virol. 2020 Jul 30;94(16). pii: JVI.01002-20. doi: 10.1128/JVI.01002-20. Print 2020 Jul 30. PubMed |
| A potent CBP/p300-Snail interaction inhibitor suppresses tumor growth and metastasis in wild-type p53-expressing cancer. Li HM, Bi YR, Li Y, Fu R, Lv WC, Jiang N, Xu Y, Ren BX, Chen YD, Xie H, Wang S, Lu T, Wu ZQ. Sci Adv. 2020 Apr 22;6(17):eaaw8500. doi: 10.1126/sciadv.aaw8500. eCollection 2020 Apr. PubMed |
| ERK-Mediated Mechanochemical Waves Direct Collective Cell Polarization. Hino N, Rossetti L, Marin-Llaurado A, Aoki K, Trepat X, Matsuda M, Hirashima T. Dev Cell. 2020 Jun 22;53(6):646-660.e8. doi: 10.1016/j.devcel.2020.05.011. Epub 2020 Jun 3. PubMed |
| CD31 (PECAM-1) Serves as the Endothelial Cell-Specific Receptor of Clostridium perfringens beta-Toxin. Bruggisser J, Tarek B, Wyder M, Muller P, von Ballmoos C, Witz G, Enzmann G, Deutsch U, Engelhardt B, Posthaus H. Cell Host Microbe. 2020 Jul 8;28(1):69-78.e6. doi: 10.1016/j.chom.2020.05.003. Epub 2020 Jun 3. PubMed |
| Proximal Biotinylation-Based Combinatory Approach for Isolating Integral Plasma Membrane Proteins. Akdag M, Yunt ZS, Kamacioglu A, Qureshi MH, Akarlar BA, Ozlu N. J Proteome Res. 2020 Aug 7;19(8):3583-3592. doi: 10.1021/acs.jproteome.0c00113. Epub 2020 Jun 15. PubMed |
| Src couples estrogen receptor to the anticipatory unfolded protein response and regulates cancer cell fate under stress. Yu L, Wang L, Kim JE, Mao C, Shapiro DJ. Biochim Biophys Acta Mol Cell Res. 2020 Oct;1867(10):118765. doi: 10.1016/j.bbamcr.2020.118765. Epub 2020 Jun 2. PubMed |
| MYC functions as a switch for natural killer cell-mediated immune surveillance of lymphoid malignancies. Swaminathan S, Hansen AS, Heftdal LD, Dhanasekaran R, Deutzmann A, Fernandez WDM, Liefwalker DF, Horton C, Mosley A, Liebersbach M, Maecker HT, Felsher DW. Nat Commun. 2020 Jun 5;11(1):2860. doi: 10.1038/s41467-020-16447-7. PubMed |
| SIRT7 antagonizes human stem cell aging as a heterochromatin stabilizer. Bi S, Liu Z, Wu Z, Wang Z, Liu X, Wang S, Ren J, Yao Y, Zhang W, Song M, Liu GH, Qu J. Protein Cell. 2020 Jul;11(7):483-504. doi: 10.1007/s13238-020-00728-4. Epub 2020 Jun 6. PubMed |
Direct-seq: programmed gRNA scaffold for streamlined scRNA-seq in CRISPR screen.
Song Q, Ni K, Liu M, Li Y, Wang L, Wang Y, Liu Y, Yu Z, Qi Y, Lu Z, Ma L.
Genome Biol. 2020 Jun 8;21(1):136. doi: 10.1186/s13059-020-02044-w.
PubMed
Associated Plasmids |
| Modulation of dopamine D1 receptors via histamine H3 receptors is a novel therapeutic target for Huntington's disease. Moreno-Delgado D, Puigdellivol M, Moreno E, Rodriguez-Ruiz M, Botta J, Gasperini P, Chiarlone A, Howell LA, Scarselli M, Casado V, Cortes A, Ferre S, Guzman M, Lluis C, Alberch J, Canela EI, Gines S, McCormick PJ. Elife. 2020 Jun 9;9. pii: 51093. doi: 10.7554/eLife.51093. PubMed |
| Selective Translation of Cell Fate Regulators Mediates Tolerance to Broad Oncogenic Stress. Cai EY, Kufeld MN, Schuster S, Arora S, Larkin M, Germanos AA, Hsieh AC, Beronja S. Cell Stem Cell. 2020 Aug 6;27(2):270-283.e7. doi: 10.1016/j.stem.2020.05.007. Epub 2020 Jun 8. PubMed |
| Endogenous DNA 3' Blocks Are Vulnerabilities for BRCA1 and BRCA2 Deficiency and Are Reversed by the APE2 Nuclease. Alvarez-Quilon A, Wojtaszek JL, Mathieu MC, Patel T, Appel CD, Hustedt N, Rossi SE, Wallace BD, Setiaputra D, Adam S, Ohashi Y, Melo H, Cho T, Gervais C, Munoz IM, Grazzini E, Young JTF, Rouse J, Zinda M, Williams RS, Durocher D. Mol Cell. 2020 Jun 18;78(6):1152-1165.e8. doi: 10.1016/j.molcel.2020.05.021. Epub 2020 Jun 8. PubMed |
Massively parallel Cas13 screens reveal principles for guide RNA design.
Wessels HH, Mendez-Mancilla A, Guo X, Legut M, Daniloski Z, Sanjana NE.
Nat Biotechnol. 2020 Jun;38(6):722-727. doi: 10.1038/s41587-020-0456-9. Epub 2020 Mar 16.
PubMed
Associated Plasmids
|
| Viral Transduction of DRG Neurons. Sasaki Y. Methods Mol Biol. 2020;2143:55-62. doi: 10.1007/978-1-0716-0585-1_5. PubMed |
| Effects of Inorganic Arsenic on Human Prostate Stem-Progenitor Cell Transformation, Autophagic Flux Blockade, and NRF2 Pathway Activation. Xie L, Hu WY, Hu DP, Shi G, Li Y, Yang J, Prins GS. Environ Health Perspect. 2020 Jun;128(6):67008. doi: 10.1289/EHP6471. Epub 2020 Jun 11. PubMed |
| The Tumour Suppressor TMEM127 Is a Nedd4-Family E3 Ligase Adaptor Required by Salmonella SteD to Ubiquitinate and Degrade MHC Class II Molecules. Alix E, Godlee C, Cerny O, Blundell S, Tocci R, Matthews S, Liu M, Pruneda JN, Swatek KN, Komander D, Sleap T, Holden DW. Cell Host Microbe. 2020 Jul 8;28(1):54-68.e7. doi: 10.1016/j.chom.2020.04.024. Epub 2020 Jun 10. PubMed |
| Targeting FTO Suppresses Cancer Stem Cell Maintenance and Immune Evasion. Su R, Dong L, Li Y, Gao M, Han L, Wunderlich M, Deng X, Li H, Huang Y, Gao L, Li C, Zhao Z, Robinson S, Tan B, Qing Y, Qin X, Prince E, Xie J, Qin H, Li W, Shen C, Sun J, Kulkarni P, Weng H, Huang H, Chen Z, Zhang B, Wu X, Olsen MJ, Muschen M, Marcucci G, Salgia R, Li L, Fathi AT, Li Z, Mulloy JC, Wei M, Horne D, Chen J. Cancer Cell. 2020 Jul 13;38(1):79-96.e11. doi: 10.1016/j.ccell.2020.04.017. Epub 2020 Jun 11. PubMed |
| Transient Primary Cilia Mediate Robust Hedgehog Pathway-Dependent Cell Cycle Control. Ho EK, Tsai AE, Stearns T. Curr Biol. 2020 Jul 20;30(14):2829-2835.e5. doi: 10.1016/j.cub.2020.05.004. Epub 2020 Jun 11. PubMed |
| Rab11b-mediated integrin recycling promotes brain metastatic adaptation and outgrowth. Howe EN, Burnette MD, Justice ME, Schnepp PM, Hedrick V, Clancy JW, Guldner IH, Lamere AT, Li J, Aryal UK, D'Souza-Schorey C, Zartman JJ, Zhang S. Nat Commun. 2020 Jun 15;11(1):3017. doi: 10.1038/s41467-020-16832-2. PubMed |
| Guanylate-binding proteins convert cytosolic bacteria into caspase-4 signaling platforms. Wandel MP, Kim BH, Park ES, Boyle KB, Nayak K, Lagrange B, Herod A, Henry T, Zilbauer M, Rohde J, MacMicking JD, Randow F. Nat Immunol. 2020 Aug;21(8):880-891. doi: 10.1038/s41590-020-0697-2. Epub 2020 Jun 15. PubMed |
| NRBF2 is a RAB7 effector required for autophagosome maturation and mediates the association of APP-CTFs with active form of RAB7 for degradation. Cai CZ, Yang C, Zhuang XX, Yuan NN, Wu MY, Tan JQ, Song JX, Cheung KH, Su H, Wang YT, Tang BS, Behrends C, Durairajan SSK, Yue Z, Li M, Lu JH. Autophagy. 2020 Jun 16:1-19. doi: 10.1080/15548627.2020.1760623. PubMed |
| Epstein-Barr Virus LMP1 Promotes Syntenin-1- and Hrs-Induced Extracellular Vesicle Formation for Its Own Secretion To Increase Cell Proliferation and Migration. Nkosi D, Sun L, Duke LC, Patel N, Surapaneni SK, Singh M, Meckes DG Jr. mBio. 2020 Jun 16;11(3). pii: mBio.00589-20. doi: 10.1128/mBio.00589-20. PubMed |
| A conformation-specific ON-switch for controlling CAR T cells with an orally available drug. Zajc CU, Dobersberger M, Schaffner I, Mlynek G, Puhringer D, Salzer B, Djinovic-Carugo K, Steinberger P, De Sousa Linhares A, Yang NJ, Obinger C, Holter W, Traxlmayr MW, Lehner M. Proc Natl Acad Sci U S A. 2020 Jun 30;117(26):14926-14935. doi: 10.1073/pnas.1911154117. Epub 2020 Jun 17. PubMed |
| Genomic deregulation of PRMT5 supports growth and stress tolerance in chronic lymphocytic leukemia. Schnormeier AK, Pommerenke C, Kaufmann M, Drexler HG, Koeppel M. Sci Rep. 2020 Jun 17;10(1):9775. doi: 10.1038/s41598-020-66224-1. PubMed |
| Heme oxygenase promotes B-Raf-dependent melanosphere formation. Jasmer KJ, Hou J, Mannino P, Cheng J, Hannink M. Pigment Cell Melanoma Res. 2020 Jun 17. doi: 10.1111/pcmr.12905. PubMed |
| PDGFRbeta plays an essential role in patient vitreous-stimulated contraction of retinal pigment epithelial cells from epiretinal membranes. Yang Y, Huang X, Ma G, Cui J, Matsubara JA, Kazlauskas A, Zhao J, Wang J, Lei H. Exp Eye Res. 2020 Aug;197:108116. doi: 10.1016/j.exer.2020.108116. Epub 2020 Jun 16. PubMed |
| Proteasome Subunits Differentially Control Myeloma Cell Viability and Proteasome Inhibitor Sensitivity. Shi CX, Zhu YX, Bruins LA, Bonolo de Campos C, Stewart W, Braggio E, Stewart AK. Mol Cancer Res. 2020 Jun 19. pii: 1541-7786.MCR-19-1026. doi: 10.1158/1541-7786.MCR-19-1026. PubMed |
| Ibrutinib is not an effective drug in primografts of TCF3-PBX1. van de Ven C, Boeree A, Stalpers F, Zwaan CM, Den Boer ML. Transl Oncol. 2020 Oct;13(10):100817. doi: 10.1016/j.tranon.2020.100817. Epub 2020 Jun 18. PubMed |
| Long-distance modulation of bystander tumor cells by CD8(+) T cell-secreted IFNgamma. Hoekstra ME, Bornes L, Dijkgraaf FE, Philips D, Pardieck IN, Toebes M, Thommen DS, van Rheenen J, Schumacher TNM. Nat Cancer. 2020 Mar;1(3):291-301. doi: 10.1038/s43018-020-0036-4. Epub 2020 Mar 9. PubMed |
| Generation of Monoclonal iPSC Lines with Stable Cas9 Expression and High Cas9 Activity. Liao JQ, Zhou G, Zhou Y. Methods Mol Biol. 2020 Jun 22. doi: 10.1007/7651_2020_304. PubMed |
| Cell Surface Receptor Identification Using Genome-Scale CRISPR/Cas9 Genetic Screens. Sharma S, Wright GJ. J Vis Exp. 2020 Jun 6;(160). doi: 10.3791/60803. PubMed |
| Sequentially induced motor neurons from human fibroblasts facilitate locomotor recovery in a rodent spinal cord injury model. Lee H, Lee HY, Lee BE, Gerovska D, Park SY, Zaehres H, Arauzo-Bravo MJ, Kim JI, Ha Y, Scholer HR, Kim JB. Elife. 2020 Jun 23;9. pii: 52069. doi: 10.7554/eLife.52069. PubMed |
| Crystal structures of human PAICS reveal substrate and product binding of an emerging cancer target. Skerlova J, Unterlass J, Gottmann M, Marttila P, Homan E, Helleday T, Jemth AS, Stenmark P. J Biol Chem. 2020 Aug 14;295(33):11656-11668. doi: 10.1074/jbc.RA120.013695. Epub 2020 Jun 22. PubMed |
| Efficient CRISPR/Cas9 genome editing in a salmonid fish cell line using a lentivirus delivery system. Gratacap RL, Regan T, Dehler CE, Martin SAM, Boudinot P, Collet B, Houston RD. BMC Biotechnol. 2020 Jun 23;20(1):35. doi: 10.1186/s12896-020-00626-x. PubMed |
| Integrated analysis reveals critical glycolytic regulators in hepatocellular carcinoma. Lu C, Fang S, Weng Q, Lv X, Meng M, Zhu J, Zheng L, Hu Y, Gao Y, Wu X, Mao J, Tang B, Zhao Z, Huang L, Ji J. Cell Commun Signal. 2020 Jun 23;18(1):97. doi: 10.1186/s12964-020-00539-4. PubMed |
| Effective Inhibition of SARS-CoV-2 Entry by Heparin and Enoxaparin Derivatives. Tandon R, Sharp JS, Zhang F, Pomin VH, Ashpole NM, Mitra D, Jin W, Liu H, Sharma P, Linhardt RJ. bioRxiv. 2020 Jun 8. doi: 10.1101/2020.06.08.140236. PubMed |
| The D614G mutation in SARS-CoV-2 Spike increases transduction of multiple human cell types. Daniloski Z, Guo X, Sanjana NE. bioRxiv. 2020 Jun 15. doi: 10.1101/2020.06.14.151357. PubMed |
| VNUT/SLC17A9, a vesicular nucleotide transporter, regulates osteoblast differentiation. Inoue A, Nakao-Kuroishi K, Kometani-Gunjigake K, Mizuhara M, Shirakawa T, Ito-Sago M, Yasuda K, Nakatomi M, Matsubara T, Tada-Shigeyama Y, Morikawa K, Kokabu S, Kawamoto T. FEBS Open Bio. 2020 Jun 26. doi: 10.1002/2211-5463.12918. PubMed |
| ESRRG and PERM1 Govern Mitochondrial Conversion in Brite/Beige Adipocyte Formation. Muller S, Perdikari A, Dapito DH, Sun W, Wollscheid B, Balaz M, Wolfrum C. Front Endocrinol (Lausanne). 2020 Jun 12;11:387. doi: 10.3389/fendo.2020.00387. eCollection 2020. PubMed |
| Newcastle Disease virus infection activates PI3K/Akt/mTOR and p38 MAPK/Mnk1 pathways to benefit viral mRNA translation via interaction of the viral NP protein and host eIF4E. Zhan Y, Yu S, Yang S, Qiu X, Meng C, Tan L, Song C, Liao Y, Liu W, Sun Y, Ding C. PLoS Pathog. 2020 Jun 30;16(6):e1008610. doi: 10.1371/journal.ppat.1008610. eCollection 2020 Jun. PubMed |
| A FAK/HDAC5 signaling axis controls osteocyte mechanotransduction. Sato T, Verma S, Andrade CDC, Omeara M, Campbell N, Wang JS, Cetinbas M, Lang A, Ausk BJ, Brooks DJ, Sadreyev RI, Kronenberg HM, Lagares D, Uda Y, Pajevic PD, Bouxsein ML, Gross TS, Wein MN. Nat Commun. 2020 Jul 1;11(1):3282. doi: 10.1038/s41467-020-17099-3. PubMed |
| Expression of ncRNAs on the DLK1-DIO3 Locus Is Associated With Basal and Mesenchymal Phenotype in Breast Epithelial Progenitor Cells. Budkova Z, Sigurdardottir AK, Briem E, Bergthorsson JT, Sigurdsson S, Magnusson MK, Traustadottir GA, Gudjonsson T, Hilmarsdottir B. Front Cell Dev Biol. 2020 Jun 16;8:461. doi: 10.3389/fcell.2020.00461. eCollection 2020. PubMed |
| Y Chromosome LncRNA are involved in Radiation Response of Male Non-Small Cell Lung Cancer Cells. Brownmiller T, Juric JA, Ivey AD, Harvey BM, Westemeier ES, Winters MT, Stevens AM, Stanley AN, Hayes KE, Sprowls SA, Gatesman Ammer AS, Walker M, Bey EA, Wu X, Lim ZF, Zhu L, Wen S, Hu G, Ma PC, Martinez I. Cancer Res. 2020 Jul 2. pii: 0008-5472.CAN-19-4032. doi: 10.1158/0008-5472.CAN-19-4032. PubMed |
| CRISPR/Cas9-mediated whole genomic wide knockout screening identifies mitochondrial ribosomal proteins involving in oxygen-glucose deprivation/reperfusion resistance. Guan X, Zhang H, Qin H, Chen C, Hu Z, Tan J, Zeng L. J Cell Mol Med. 2020 Jul 2. doi: 10.1111/jcmm.15580. PubMed |
| Highly efficient 'hit-and-run' genome editing with unconcentrated lentivectors carrying Vpr.Prot.Cas9 protein produced from RRE-containing transcripts. Indikova I, Indik S. Nucleic Acids Res. 2020 Aug 20;48(14):8178-8187. doi: 10.1093/nar/gkaa561. PubMed |
| EXO1 Plays a Carcinogenic Role in Hepatocellular Carcinoma and is related to the regulation of FOXP3. Yang G, Dong K, Zhang Z, Zhang E, Liang B, Chen X, Huang Z. J Cancer. 2020 Jun 16;11(16):4917-4932. doi: 10.7150/jca.40673. eCollection 2020. PubMed |
| Effects of PYRIN-containing Apaf1-like protein 1 on isoflurane-induced postoperative cognitive dysfunction in aged rats. Zhang X, Fan X, Li F, Qiu J, Zhang Y. Mol Med Rep. 2020 Aug;22(2):1391-1399. doi: 10.3892/mmr.2020.11244. Epub 2020 Jun 16. PubMed |
| Evaluation of an aldo-keto reductase gene signature with prognostic significance in colon cancer via activation of epithelial to mesenchymal transition and the p70S6K pathway. Demirkol Canli S, Seza EG, Sheraj I, Gomceli I, Turhan N, Carberry S, Prehn JHM, Gure AO, Banerjee S. Carcinogenesis. 2020 Jul 6. pii: 5867997. doi: 10.1093/carcin/bgaa072. PubMed |
| CCN1/Cyr61 is required in osteoblasts for responsiveness to the anabolic activity of PTH. Zhao G, Kim EW, Jiang J, Bhoot C, Charles KR, Baek J, Mohan S, Adams JS, Tetradis S, Lyons KM. J Bone Miner Res. 2020 Jul 7. doi: 10.1002/jbmr.4128. PubMed |
Revealing the Activity of Trimeric G-proteins in Live Cells with a Versatile Biosensor Design.
Maziarz M, Park JC, Leyme A, Marivin A, Garcia-Lopez A, Patel PP, Garcia-Marcos M.
Cell. 2020 Jun 27. pii: S0092-8674(20)30752-2. doi: 10.1016/j.cell.2020.06.020.
PubMed
Associated Plasmids |
lentiMPRA and MPRAflow for high-throughput functional characterization of gene regulatory elements.
Gordon MG, Inoue F, Martin B, Schubach M, Agarwal V, Whalen S, Feng S, Zhao J, Ashuach T, Ziffra R, Kreimer A, Georgakopoulous-Soares I, Yosef N, Ye CJ, Pollard KS, Shendure J, Kircher M, Ahituv N.
Nat Protoc. 2020 Aug;15(8):2387-2412. doi: 10.1038/s41596-020-0333-5. Epub 2020 Jul 8.
PubMed
Associated Plasmids |
| An adipokine feedback regulating diurnal food intake rhythms in mice. Tsang AH, Koch CE, Kiehn JT, Schmidt CX, Oster H. Elife. 2020 Jul 9;9. pii: 55388. doi: 10.7554/eLife.55388. PubMed |
| Microtubule motor transport in the delivery of melanosomes to the actin-rich apical domain of the retinal pigment epithelium. Jiang M, Paniagua AE, Volland S, Wang H, Balaji A, Li DG, Lopes VS, Burgess BL, Williams DS. J Cell Sci. 2020 Aug 4;133(15). pii: jcs.242214. doi: 10.1242/jcs.242214. PubMed |
High-performance CRISPR-Cas12a genome editing for combinatorial genetic screening.
Gier RA, Budinich KA, Evitt NH, Cao Z, Freilich ES, Chen Q, Qi J, Lan Y, Kohli RM, Shi J.
Nat Commun. 2020 Jul 13;11(1):3455. doi: 10.1038/s41467-020-17209-1.
PubMed
Associated Plasmids |
Optimization of AsCas12a for combinatorial genetic screens in human cells.
DeWeirdt PC, Sanson KR, Sangree AK, Hegde M, Hanna RE, Feeley MN, Griffith AL, Teng T, Borys SM, Strand C, Joung JK, Kleinstiver BP, Pan X, Huang A, Doench JG.
Nat Biotechnol. 2020 Jul 13. pii: 10.1038/s41587-020-0600-6. doi: 10.1038/s41587-020-0600-6.
PubMed
Associated Plasmids |
| HIV-1 replication complexes accumulate in nuclear speckles and integrate into speckle-associated genomic domains. Francis AC, Marin M, Singh PK, Achuthan V, Prellberg MJ, Palermino-Rowland K, Lan S, Tedbury PR, Sarafianos SG, Engelman AN, Melikyan GB. Nat Commun. 2020 Jul 14;11(1):3505. doi: 10.1038/s41467-020-17256-8. PubMed |
| Ribosome Recycling by ABCE1 Links Lysosomal Function and Iron Homeostasis to 3' UTR-Directed Regulation and Nonsense-Mediated Decay. Zhu X, Zhang H, Mendell JT. Cell Rep. 2020 Jul 14;32(2):107895. doi: 10.1016/j.celrep.2020.107895. PubMed |
| Macrophage Exosomes Resolve Atherosclerosis by Regulating Hematopoiesis and Inflammation via MicroRNA Cargo. Bouchareychas L, Duong P, Covarrubias S, Alsop E, Phu TA, Chung A, Gomes M, Wong D, Meechoovet B, Capili A, Yamamoto R, Nakauchi H, McManus MT, Carpenter S, Van Keuren-Jensen K, Raffai RL. Cell Rep. 2020 Jul 14;32(2):107881. doi: 10.1016/j.celrep.2020.107881. PubMed |
| Single-cell lineage analysis reveals genetic and epigenetic interplay in glioblastoma drug resistance. Eyler CE, Matsunaga H, Hovestadt V, Vantine SJ, van Galen P, Bernstein BE. Genome Biol. 2020 Jul 15;21(1):174. doi: 10.1186/s13059-020-02085-1. PubMed |
| Single point mutations within the Coxsackie B virus receptor-binding site promote resistance against soluble virus receptor traps. Pinkert S, Kopp A, Bruckner V, Fechner H, Beling A. J Virol. 2020 Jul 15. pii: JVI.00952-20. doi: 10.1128/JVI.00952-20. PubMed |
| Beclin1 Binds to Enterovirus 71 3D Protein to Promote the Virus Replication. Xiang Q, Wan P, Yang G, Huang S, Qin M, Yang H, Luo Z, Wu K, Wu J. Viruses. 2020 Jul 14;12(7). pii: v12070756. doi: 10.3390/v12070756. PubMed |
| A rare variant of African ancestry activates 8q24 lncRNA hub by modulating cancer associated enhancer. Walavalkar K, Saravanan B, Singh AK, Jayani RS, Nair A, Farooq U, Islam Z, Soota D, Mann R, Shivaprasad PV, Freedman ML, Sabarinathan R, Haiman CA, Notani D. Nat Commun. 2020 Jul 17;11(1):3598. doi: 10.1038/s41467-020-17325-y. PubMed |
| Tuning the Expression of Long Noncoding RNA Loci with CRISPR Interference. Stojic L. Methods Mol Biol. 2020;2161:1-16. doi: 10.1007/978-1-0716-0680-3_1. PubMed |
| Tandem CAR-T cells targeting CD70 and B7-H3 exhibit potent preclinical activity against multiple solid tumors. Yang M, Tang X, Zhang Z, Gu L, Wei H, Zhao S, Zhong K, Mu M, Huang C, Jiang C, Xu J, Guo G, Zhou L, Tong A. Theranostics. 2020 Jun 18;10(17):7622-7634. doi: 10.7150/thno.43991. eCollection 2020. PubMed |
| Inhibition of the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) stimulates osteoblastogenesis by potentiating bone morphogenetic protein 2 (BMP2) responses. Farhat T, Dudakovic A, Chung JH, van Wijnen AJ, St-Arnaud R. J Cell Physiol. 2020 Jul 19. doi: 10.1002/jcp.29927. PubMed |
| Tracking cells in epithelial acini by light sheet microscopy reveals proximity effects in breast cancer initiation. Alladin A, Chaible L, Garcia Del Valle L, Sabine R, Loeschinger M, Wachsmuth M, Heriche JK, Tischer C, Jechlinger M. Elife. 2020 Jul 21;9. pii: 54066. doi: 10.7554/eLife.54066. PubMed |
| Redox Regulation of PPARgamma in Polarized Macrophages. Trumper V, Wittig I, Heidler J, Richter F, Brune B, von Knethen A. PPAR Res. 2020 Jul 1;2020:8253831. doi: 10.1155/2020/8253831. eCollection 2020. PubMed |
| Conversion of Neural Stem Cells into Functional Neuron-Like Cells by MicroRNA-218: Differential Expression of Functionality Genes. Khalil W, Tiraihi T, Soleimani M, Baheiraei N, Zibara K. Neurotox Res. 2020 Jul 21. pii: 10.1007/s12640-020-00244-7. doi: 10.1007/s12640-020-00244-7. PubMed |
| RSK2 Maintains Adult Estrogen Homeostasis by Inhibiting ERK1/2-Mediated Degradation of Estrogen Receptor Alpha. Ludwik KA, Sandusky ZM, Stauffer KM, Li Y, Boyd KL, O'Doherty GA, Stricker TP, Lannigan DA. Cell Rep. 2020 Jul 21;32(3):107931. doi: 10.1016/j.celrep.2020.107931. PubMed |
| A pooled genome-wide screening strategy to identify and rank influenza host restriction factors in cell-based vaccine production platforms. Sharon DM, Nesdoly S, Yang HJ, Gelinas JF, Xia Y, Ansorge S, Kamen AA. Sci Rep. 2020 Jul 22;10(1):12166. doi: 10.1038/s41598-020-68934-y. PubMed |
| SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2. Clausen TM, Sandoval DR, Spliid CB, Pihl J, Painter CD, Thacker BE, Glass CA, Narayanan A, Majowicz SA, Zhang Y, Torres JL, Golden GJ, Porell R, Garretson AF, Laubach L, Feldman J, Yin X, Pu Y, Hauser B, Caradonna TM, Kellman BP, Martino C, Gordts PLSM, Leibel SL, Chanda SK, Schmidt AG, Godula K, Jose J, Corbett KD, Ward AB, Carlin AF, Esko JD. bioRxiv. 2020 Jul 14. doi: 10.1101/2020.07.14.201616. PubMed |
| The CDK4/6-EZH2 pathway is a potential therapeutic target for psoriasis. Muller A, Dickmanns A, Resch C, Schakel K, Hailfinger S, Dobbelstein M, Schulze-Osthoff K, Kramer D. J Clin Invest. 2020 Jul 23. pii: 134217. doi: 10.1172/JCI134217. PubMed |
| Exploiting the Therapeutic Interaction of WNT Pathway Activation and Asparaginase for Colorectal Cancer Therapy. Hinze L, Labrosse R, Degar J, Han T, Schatoff EM, Schreek S, Karim S, McGuckin C, Sacher JR, Wagner F, Stanulla M, Yuan C, Sicinska E, Giannakis M, Ng K, Dow LE, Gutierrez A. Cancer Discov. 2020 Jul 23. pii: 2159-8290.CD-19-1472. doi: 10.1158/2159-8290.CD-19-1472. PubMed |
| Intraductal Transplantation Models of Human Pancreatic Ductal Adenocarcinoma Reveal Progressive Transition of Molecular Subtypes. Miyabayashi K, Baker LA, Deschenes A, Traub B, Caligiuri G, Plenker D, Alagesan B, Belleau P, Li S, Kendall J, Jang GH, Kawaguchi RK, Somerville TDD, Tiriac H, Hwang CI, Burkhart RA, Roberts NJ, Wood LD, Hruban RH, Gillis J, Krasnitz A, Vakoc CR, Wigler M, Notta F, Gallinger S, Park Y, Tuveson DA. Cancer Discov. 2020 Oct;10(10):1566-1589. doi: 10.1158/2159-8290.CD-20-0133. Epub 2020 Jul 23. PubMed |
| TRPV4 Inhibition and CRISPR-Cas9 Knockout Reduce Inflammation Induced by Hyperphysiological Stretching in Human Annulus Fibrosus Cells. Cambria E, Arlt MJE, Wandel S, Krupkova O, Hitzl W, Passini FS, Hausmann ON, Snedeker JG, Ferguson SJ, Wuertz-Kozak K. Cells. 2020 Jul 21;9(7). pii: cells9071736. doi: 10.3390/cells9071736. PubMed |
| Dianhydrogalactitol synergizes with topoisomerase poisons to overcome DNA repair activity in tumor cells. Zhai B, Li Y, Kotapalli SS, Bacha J, Brown D, Steino A, Daugaard M. Cell Death Dis. 2020 Jul 24;11(7):577. doi: 10.1038/s41419-020-02780-8. PubMed |
| Derivation and Characterization of Immortalized Human Muscle Satellite Cell Clones from Muscular Dystrophy Patients and Healthy Individuals. Massenet J, Gitiaux C, Magnan M, Cuvellier S, Hubas A, Nusbaum P, Dilworth FJ, Desguerre I, Chazaud B. Cells. 2020 Jul 26;9(8). pii: cells9081780. doi: 10.3390/cells9081780. PubMed |
| IGF2BP3 and miR191-5p synergistically increase HCC cell invasiveness by altering ZO-1 expression. Gao Y, Luo T, Ouyang X, Zhu C, Zhu J, Qin X. Oncol Lett. 2020 Aug;20(2):1423-1431. doi: 10.3892/ol.2020.11693. Epub 2020 May 30. PubMed |
| PAG1 directs SRC-family kinase intracellular localization to mediate receptor tyrosine kinase-induced differentiation. Foltz L, Palacios-Moreno J, Mayfield M, Kinch S, Dillon J, Syrenne J, Levy T, Grimes M. Mol Biol Cell. 2020 Sep 15;31(20):2269-2282. doi: 10.1091/mbc.E20-02-0135. Epub 2020 Jul 29. PubMed |
| An ErbB2 splice variant lacking exon 16 drives lung carcinoma. Smith HW, Yang L, Ling C, Walsh A, Martinez VD, Boucher J, Zuo D, Sokol ES, Pavlick DC, Frampton GM, Chmielecki J, Jones LM, Roux PP, Lockwood WW, Muller WJ. Proc Natl Acad Sci U S A. 2020 Aug 18;117(33):20139-20148. doi: 10.1073/pnas.2007474117. Epub 2020 Jul 29. PubMed |
| An Optimized Protocol for Human Direct Cardiac Reprogramming. Garbutt TA, Zhou Y, Keepers B, Liu J, Qian L. STAR Protoc. 2020 Jun 19;1(1). doi: 10.1016/j.xpro.2019.100010. Epub 2020 Jun 3. PubMed |
| Alix and Syntenin-1 direct amyloid precursor protein trafficking into extracellular vesicles. Cone AS, Hurwitz SN, Lee GS, Yuan X, Zhou Y, Li Y, Meckes DG Jr. BMC Mol Cell Biol. 2020 Jul 30;21(1):58. doi: 10.1186/s12860-020-00302-0. PubMed |
| Elevating Insulin Signaling Using a Constitutively Active Insulin Receptor Increases Glucose Metabolism and Expression of GLUT3 in Hippocampal Neurons. Frazier HN, Ghoweri AO, Anderson KL, Lin RL, Popa GJ, Mendenhall MD, Reagan LP, Craven RJ, Thibault O. Front Neurosci. 2020 Jul 7;14:668. doi: 10.3389/fnins.2020.00668. eCollection 2020. PubMed |
| The potency of hsa-miR-9-1 overexpression in photoreceptor differentiation of conjunctiva mesenchymal stem cells on a 3D nanofibrous scaffold. Rahmani A, Naderi M, Barati G, Arefian E, Jedari B, Nadri S. Biochem Biophys Res Commun. 2020 Aug 27;529(3):526-532. doi: 10.1016/j.bbrc.2020.06.006. Epub 2020 Jul 14. PubMed |
| LIM-Nebulette Reinforces Podocyte Structural Integrity by Linking Actin and Vimentin Filaments. Ge X, Zhang T, Yu X, Muwonge AN, Anandakrishnan N, Wong NJ, Haydak JC, Reid JM, Fu J, Wong JS, Bhattacharya S, Cuttitta CM, Zhong F, Gordon RE, Salem F, Janssen W, Hone JC, Zhang A, Li H, He JC, Gusella GL, Campbell KN, Azeloglu EU. J Am Soc Nephrol. 2020 Oct;31(10):2372-2391. doi: 10.1681/ASN.2019121261. Epub 2020 Jul 31. PubMed |
| Targeting the Synthetic Vulnerability of PTEN-Deficient Glioblastoma Cells with MCL1 Inhibitors. Chen C, Zhu S, Zhang X, Zhou T, Gu J, Xu Y, Wan Q, Qi X, Chai Y, Liu X, Chen L, Yan J, Hua Y, Lin F. Mol Cancer Ther. 2020 Oct;19(10):2001-2011. doi: 10.1158/1535-7163.MCT-20-0099. Epub 2020 Jul 31. PubMed |
| Dynamic chromatin accessibility landscape changes following interleukin-1 stimulation. Barter MJ, Cheung K, Falk J, Panagiotopoulos AC, Cosimini C, O'Brien S, Teja-Putri K, Neill G, Deehan DJ, Young DA. Epigenetics. 2021 Jan;16(1):106-119. doi: 10.1080/15592294.2020.1789266. Epub 2020 Aug 2. PubMed |
| KRAB domain of ZFP568 disrupts TRIM28-mediated abnormal interactions in cancer cells. Kumar J, Kaur G, Ren R, Lu Y, Lin K, Li J, Huang Y, Patel A, Barton MC, Macfarlan T, Zhang X, Cheng X. NAR Cancer. 2020 Jun;2(2):zcaa007. doi: 10.1093/narcan/zcaa007. Epub 2020 May 18. PubMed |
| Rational discovery of molecular glue degraders via scalable chemical profiling. Mayor-Ruiz C, Bauer S, Brand M, Kozicka Z, Siklos M, Imrichova H, Kaltheuner IH, Hahn E, Seiler K, Koren A, Petzold G, Fellner M, Bock C, Muller AC, Zuber J, Geyer M, Thoma NH, Kubicek S, Winter GE. Nat Chem Biol. 2020 Nov;16(11):1199-1207. doi: 10.1038/s41589-020-0594-x. Epub 2020 Aug 3. PubMed |
| Osteosarcoma-Derived Extracellular Vesicles Induce Lung Fibroblast Reprogramming. Mazumdar A, Urdinez J, Boro A, Migliavacca J, Arlt MJE, Muff R, Fuchs B, Snedeker JG, Gvozdenovic A. Int J Mol Sci. 2020 Jul 30;21(15). pii: ijms21155451. doi: 10.3390/ijms21155451. PubMed |
Multiplexed Optical Sensors in Arrayed Islands of Cells for multimodal recordings of cellular physiology.
Werley CA, Boccardo S, Rigamonti A, Hansson EM, Cohen AE.
Nat Commun. 2020 Aug 4;11(1):3881. doi: 10.1038/s41467-020-17607-5.
PubMed
Associated Plasmids |
| Preclinical Assessment of Efficacy and Safety Analysis of CAR-T Cells (ISIKOK-19) Targeting CD19-Expressing B-Cells for the First Turkish Academic Clinical Trial with Relapsed/Refractory ALL and NHL Patients Tastan C, Kancagi DD, Turan RD, Yurtsever B, Cakirsoy D, Abanuz S, Yilanci M, Seyis U, Ozer S, Mert S, Kayhan CK, Tokat F, Acikel Elmas M, Birdogan S, Arbak S, Yalcin K, Sezgin A, Kizilkilic E, Hemsinlioglu C, Ince U, Ratip S, Ovali E. Turk J Haematol. 2020 Nov 19;37(4):234-247. doi: 10.4274/tjh.galenos.2020.2020.0070. Epub 2020 Aug 4. PubMed |
| Saffron Crudes and Compounds Restrict MACC1-Dependent Cell Proliferation and Migration of Colorectal Cancer Cells. Gullu N, Kobelt D, Brim H, Rahman S, Timm L, Smith J, Soleimani A, Di Marco S, Bisti S, Ashktorab H, Stein U. Cells. 2020 Aug 3;9(8). pii: cells9081829. doi: 10.3390/cells9081829. PubMed |
| The oncofetal RNA-binding protein IGF2BP1 is a druggable, post-transcriptional super-enhancer of E2F-driven gene expression in cancer. Muller S, Bley N, Busch B, Glass M, Lederer M, Misiak C, Fuchs T, Wedler A, Haase J, Bertoldo JB, Michl P, Huttelmaier S. Nucleic Acids Res. 2020 Sep 4;48(15):8576-8590. doi: 10.1093/nar/gkaa653. PubMed |
| Evolutionary divergence reveals the molecular basis of EMRE dependence of the human MCU. MacEwen MJ, Markhard AL, Bozbeyoglu M, Bradford F, Goldberger O, Mootha VK, Sancak Y. Life Sci Alliance. 2020 Aug 7;3(10). pii: 3/10/e202000718. doi: 10.26508/lsa.202000718. Print 2020 Oct. PubMed |
| Direct analysis of brain phenotypes via neural blastocyst complementation. Dai HQ, Liang Z, Chang AN, Chapdelaine-Williams AM, Alvarado B, Pollen AA, Alt FW, Schwer B. Nat Protoc. 2020 Oct;15(10):3154-3181. doi: 10.1038/s41596-020-0364-y. Epub 2020 Aug 10. PubMed |
| Dorsoventral polarity directs cell responses to migration track geometries. Wisniewski EO, Mistriotis P, Bera K, Law RA, Zhang J, Nikolic M, Weiger M, Parlani M, Tuntithavornwat S, Afthinos A, Zhao R, Wirtz D, Kalab P, Scarcelli G, Friedl P, Konstantopoulos K. Sci Adv. 2020 Jul 31;6(31):eaba6505. doi: 10.1126/sciadv.aba6505. eCollection 2020 Jul. PubMed |
| Tetraspanin-7 regulation of L-type voltage-dependent calcium channels controls pancreatic beta-cell insulin secretion. Dickerson MT, Dadi PK, Butterworth RB, Nakhe AY, Graff SM, Zaborska KE, Schaub CM, Jacobson DA. J Physiol. 2020 Nov;598(21):4887-4905. doi: 10.1113/JP279941. Epub 2020 Sep 1. PubMed |
| Rapid generation of regionally specified CNS neurons by sequential patterning and conversion of human induced pluripotent stem cells. Chen M, Maimaitili M, Habekost M, Gill KP, Mermet-Joret N, Nabavi S, Febbraro F, Denham M. Stem Cell Res. 2020 Oct;48:101945. doi: 10.1016/j.scr.2020.101945. Epub 2020 Aug 3. PubMed |
| A novel approach to genetic engineering of T-cell subsets by hematopoietic stem cell infection with a bicistronic lentivirus. Bogert NV, Furkel J, Din S, Braren I, Eckstein V, Muller JA, Uhlmann L, Katus HA, Konstandin MH. Sci Rep. 2020 Aug 13;10(1):13740. doi: 10.1038/s41598-020-70793-6. PubMed |
| Splicing variation of BMP2K balances abundance of COPII assemblies and autophagic degradation in erythroid cells. Cendrowski J, Kaczmarek M, Mazur M, Kuzmicz-Kowalska K, Jastrzebski K, Brewinska-Olchowik M, Kominek A, Piwocka K, Miaczynska M. Elife. 2020 Aug 14;9. pii: 58504. doi: 10.7554/eLife.58504. PubMed |
A multiplexed bioluminescent reporter for sensitive and non-invasive tracking of DNA double strand break repair dynamics in vitro and in vivo.
Chien JC, Tabet E, Pinkham K, da Hora CC, Chang JC, Lin S, Badr CE, Lai CP.
Nucleic Acids Res. 2020 Aug 14. pii: 5892751. doi: 10.1093/nar/gkaa669.
PubMed
Associated Plasmids |
| RCC2 Promotes Esophageal Cancer Growth by Regulating Activity and Expression of the Sox2 Transcription Factor. Calderon-Aparicio A, Yamamoto H, De Vitto H, Zhang T, Wang Q, Bode AM, Dong Z. Mol Cancer Res. 2020 Nov;18(11):1660-1674. doi: 10.1158/1541-7786.MCR-19-1152. Epub 2020 Aug 14. PubMed |
| Discovery of a molecular glue promoting CDK12-DDB1 interaction to trigger cyclin K degradation. Lv L, Chen P, Cao L, Li Y, Zeng Z, Cui Y, Wu Q, Li J, Wang JH, Dong MQ, Qi X, Han T. Elife. 2020 Aug 17;9. pii: 59994. doi: 10.7554/eLife.59994. PubMed |
Enhancer RNAs predict enhancer-gene regulatory links and are critical for enhancer function in neuronal systems.
Carullo NVN, Phillips Iii RA, Simon RC, Soto SAR, Hinds JE, Salisbury AJ, Revanna JS, Bunner KD, Ianov L, Sultan FA, Savell KE, Gersbach CA, Day JJ.
Nucleic Acids Res. 2020 Aug 18. pii: 5893972. doi: 10.1093/nar/gkaa671.
PubMed
Associated Plasmids |
| MYC-binding lncRNA EPIC1 promotes AKT-mTORC1 signaling and rapamycin resistance in breast and ovarian cancer. Wang Y, Zhang M, Wang Z, Guo W, Yang D. Mol Carcinog. 2020 Oct;59(10):1188-1198. doi: 10.1002/mc.23248. Epub 2020 Aug 18. PubMed |
| Age-induced accumulation of methylmalonic acid promotes tumour progression. Gomes AP, Ilter D, Low V, Endress JE, Fernandez-Garcia J, Rosenzweig A, Schild T, Broekaert D, Ahmed A, Planque M, Elia I, Han J, Kinzig C, Mullarky E, Mutvei AP, Asara J, de Cabo R, Cantley LC, Dephoure N, Fendt SM, Blenis J. Nature. 2020 Sep;585(7824):283-287. doi: 10.1038/s41586-020-2630-0. Epub 2020 Aug 19. PubMed |
| TNF-alpha suppresses SHOX2 expression via NF-kappaB signaling pathway and promotes intervertebral disc degeneration and related pain in a rat model. Ye F, Xu Y, Lin F, Zheng Z. J Orthop Res. 2020 Aug 20. doi: 10.1002/jor.24832. PubMed |
| Safe CRISPR-Cas9 Inhibition of HIV-1 with High Specificity and Broad-Spectrum Activity by Targeting LTR NF-kappaB Binding Sites. Chung CH, Allen AG, Atkins AJ, Sullivan NT, Homan G, Costello R, Madrid R, Nonnemacher MR, Dampier W, Wigdahl B. Mol Ther Nucleic Acids. 2020 Sep 4;21:965-982. doi: 10.1016/j.omtn.2020.07.016. Epub 2020 Jul 15. PubMed |
| CIC de novo loss of function variants contribute to cerebral folate deficiency by downregulating FOLR1 expression. Cao X, Wolf A, Kim SE, Cabrera RM, Wlodarczyk BJ, Zhu H, Parker M, Lin Y, Steele JW, Han X, Ramaekers VT, Steinfeld R, Finnell RH, Lei Y. J Med Genet. 2021 Jul;58(7):484-494. doi: 10.1136/jmedgenet-2020-106987. Epub 2020 Aug 20. PubMed |
| Engineering AvidCARs for combinatorial antigen recognition and reversible control of CAR function. Salzer B, Schueller CM, Zajc CU, Peters T, Schoeber MA, Kovacic B, Buri MC, Lobner E, Dushek O, Huppa JB, Obinger C, Putz EM, Holter W, Traxlmayr MW, Lehner M. Nat Commun. 2020 Aug 20;11(1):4166. doi: 10.1038/s41467-020-17970-3. PubMed |
| Functional Interplay between Histone H2B ADP-Ribosylation and Phosphorylation Controls Adipogenesis. Huang D, Camacho CV, Setlem R, Ryu KW, Parameswaran B, Gupta RK, Kraus WL. Mol Cell. 2020 Sep 17;79(6):934-949.e14. doi: 10.1016/j.molcel.2020.08.002. Epub 2020 Aug 20. PubMed |
| WIP Modulates Oxidative Stress through NRF2/KEAP1 in Glioblastoma Cells. Escoll M, Lastra D, Robledinos-Anton N, Wandosell F, Anton IM, Cuadrado A. Antioxidants (Basel). 2020 Aug 20;9(9). pii: antiox9090773. doi: 10.3390/antiox9090773. PubMed |
| Integrative protocols for an in vitro generation of pancreatic progenitors from human dental pulp stem cells. Sawangmake C, Rodprasert W, Osathanon T, Pavasant P. Biochem Biophys Res Commun. 2020 Sep 10;530(1):222-229. doi: 10.1016/j.bbrc.2020.06.145. Epub 2020 Aug 3. PubMed |
| Profiling of immune related genes silenced in EBV-positive gastric carcinoma identified novel restriction factors of human gammaherpesviruses. Fiches GN, Zhou D, Kong W, Biswas A, Ahmed EH, Baiocchi RA, Zhu J, Santoso N. PLoS Pathog. 2020 Aug 25;16(8):e1008778. doi: 10.1371/journal.ppat.1008778. eCollection 2020 Aug. PubMed |
| Altered 3D chromatin structure permits inversional recombination at the IgH locus. Qiu X, Ma F, Zhao M, Cao Y, Shipp L, Liu A, Dutta A, Singh A, Braikia FZ, De S, Wood WH 3rd, Becker KG, Zhou W, Ji H, Zhao K, Atchison ML, Sen R. Sci Adv. 2020 Aug 14;6(33):eaaz8850. doi: 10.1126/sciadv.aaz8850. eCollection 2020 Aug. PubMed |
| Genetic evidence for an inhibitory role of tomosyn in insulin-stimulated GLUT4 exocytosis. Wang S, Liu Y, Crisman L, Wan C, Miller J, Yu H, Shen J. Traffic. 2020 Oct;21(10):636-646. doi: 10.1111/tra.12760. PubMed |
| A cross-kingdom conserved ER-phagy receptor maintains endoplasmic reticulum homeostasis during stress. Stephani M, Picchianti L, Gajic A, Beveridge R, Skarwan E, Sanchez de Medina Hernandez V, Mohseni A, Clavel M, Zeng Y, Naumann C, Matuszkiewicz M, Turco E, Loefke C, Li B, Durnberger G, Schutzbier M, Chen HT, Abdrakhmanov A, Savova A, Chia KS, Djamei A, Schaffner I, Abel S, Jiang L, Mechtler K, Ikeda F, Martens S, Clausen T, Dagdas Y. Elife. 2020 Aug 27;9. pii: 58396. doi: 10.7554/eLife.58396. PubMed |
| KIAA1522 potentiates TNFalpha-NFkappaB signaling to antagonize platinum-based chemotherapy in lung adenocarcinoma. Wang B, Jing T, Jin W, Chen J, Wu C, Wang M, Liu Y. J Exp Clin Cancer Res. 2020 Aug 27;39(1):170. doi: 10.1186/s13046-020-01684-x. PubMed |
| Human immune disorder associated with homozygous hypomorphic mutation affecting MALT1B splice variant. Kutukculer N, Seeholzer T, O'Neill TJ, Grass C, Aykut A, Karaca NE, Durmaz A, Cogulu O, Aksu G, Gehring T, Gewies A, Krappmann D. J Allergy Clin Immunol. 2021 Feb;147(2):775-778.e8. doi: 10.1016/j.jaci.2020.07.034. Epub 2020 Aug 25. PubMed |
| Quantifying the Brain Metastatic Tumor Micro-Environment using an Organ-On-A Chip 3D Model, Machine Learning, and Confocal Tomography. Oliver CR, Westerhof TM, Castro MG, Merajver SD. J Vis Exp. 2020 Aug 16;(162). doi: 10.3791/61654. PubMed |
| A drug screening toolkit based on the -1 ribosomal frameshifting of SARS-CoV-2. Chen Y, Tao H, Shen S, Miao Z, Li L, Jia Y, Zhang H, Bai X, Fu X. Heliyon. 2020 Aug;6(8):e04793. doi: 10.1016/j.heliyon.2020.e04793. Epub 2020 Aug 26. PubMed |
| A simple protein-based surrogate neutralization assay for SARS-CoV-2. Abe KT, Li Z, Samson R, Samavarchi-Tehrani P, Valcourt EJ, Wood H, Budylowski P, Dupuis AP 2nd, Girardin RC, Rathod B, Wang JH, Barrios-Rodiles M, Colwill K, McGeer AJ, Mubareka S, Gommerman JL, Durocher Y, Ostrowski M, McDonough KA, Drebot MA, Drews SJ, Rini JM, Gingras AC. JCI Insight. 2020 Oct 2;5(19). pii: 142362. doi: 10.1172/jci.insight.142362. PubMed |
| miR-183/96/182 cluster is an important morphogenetic factor targeting PAX6 expression in differentiating human retinal organoids. Peskova L, Jurcikova D, Vanova T, Krivanek J, Capandova M, Sramkova Z, Sebestikova J, Kolouskova M, Kotasova H, Streit L, Barta T. Stem Cells. 2020 Sep 1. doi: 10.1002/stem.3272. PubMed |
| Complex roles of the actin-binding protein Girdin/GIV in DNA damage-induced apoptosis of cancer cells. Chen C, Enomoto A, Weng L, Taki T, Shiraki Y, Mii S, Ichihara R, Kanda M, Koike M, Kodera Y, Takahashi M. Cancer Sci. 2020 Nov;111(11):4303-4317. doi: 10.1111/cas.14637. Epub 2020 Sep 19. PubMed |
| An Excitable Ras/PI3K/ERK Signaling Network Controls Migration and Oncogenic Transformation in Epithelial Cells. Zhan H, Bhattacharya S, Cai H, Iglesias PA, Huang CH, Devreotes PN. Dev Cell. 2020 Sep 14;54(5):608-623.e5. doi: 10.1016/j.devcel.2020.08.001. Epub 2020 Sep 1. PubMed |
| Most Commonly Mutated Genes in High-Grade Serous Ovarian Carcinoma Are Nonessential for Ovarian Surface Epithelial Stem Cell Transformation. Yamulla RJ, Nalubola S, Flesken-Nikitin A, Nikitin AY, Schimenti JC. Cell Rep. 2020 Sep 1;32(9):108086. doi: 10.1016/j.celrep.2020.108086. PubMed |
| Mechanics of a multilayer epithelium instruct tumour architecture and function. Fiore VF, Krajnc M, Quiroz FG, Levorse J, Pasolli HA, Shvartsman SY, Fuchs E. Nature. 2020 Sep;585(7825):433-439. doi: 10.1038/s41586-020-2695-9. Epub 2020 Sep 2. PubMed |
| Repurposing of KLF5 activates a cell cycle signature during the progression from a precursor state to oesophageal adenocarcinoma. Rogerson C, Ogden S, Britton E, Ang Y, Sharrocks AD. Elife. 2020 Sep 3;9:e57189. doi: 10.7554/eLife.57189. PubMed |
| Establishment and transcriptomic features of an immortalized hepatic cell line of the Chinese tree shrew. Zhang X, Yu D, Wu Y, Gu T, Ma N, Dong S, Yao YG. Appl Microbiol Biotechnol. 2020 Oct;104(20):8813-8823. doi: 10.1007/s00253-020-10855-x. Epub 2020 Sep 3. PubMed |
| Endogenous retroviruses drive species-specific germline transcriptomes in mammals. Sakashita A, Maezawa S, Takahashi K, Alavattam KG, Yukawa M, Hu YC, Kojima S, Parrish NF, Barski A, Pavlicev M, Namekawa SH. Nat Struct Mol Biol. 2020 Oct;27(10):967-977. doi: 10.1038/s41594-020-0487-4. Epub 2020 Sep 7. PubMed |
| Effects of IGF-1 on Proliferation, Angiogenesis, Tumor Stem Cell Populations and Activation of AKT and Hedgehog Pathways in Oral Squamous Cell Carcinoma. Ferreira Mendes JM, de Faro Valverde L, Torres Andion Vidal M, Paredes BD, Coelho P, Allahdadi KJ, Coletta RD, Souza BSF, Rocha CAG. Int J Mol Sci. 2020 Sep 5;21(18). pii: ijms21186487. doi: 10.3390/ijms21186487. PubMed |
| YAP-Mediated Repression of HRK Regulates Tumor Growth, Therapy Response, and Survival Under Tumor Environmental Stress in Neuroblastoma. Shim J, Lee JY, Jonus HC, Arnold A, Schnepp RW, Janssen KM, Maximov V, Goldsmith KC. Cancer Res. 2020 Nov 1;80(21):4741-4753. doi: 10.1158/0008-5472.CAN-20-0025. Epub 2020 Sep 8. PubMed |
| Infection of Brain Organoids and 2D Cortical Neurons with SARS-CoV-2 Pseudovirus. Yi SA, Nam KH, Yun J, Gim D, Joe D, Kim YH, Kim HJ, Han JW, Lee J. Viruses. 2020 Sep 8;12(9). pii: v12091004. doi: 10.3390/v12091004. PubMed |
| In Vivo Reporter Assays Uncover Changes in Enhancer Activity Caused by Type 2 Diabetes-Associated Single Nucleotide Polymorphisms. Eufrasio A, Perrod C, Ferreira FJ, Duque M, Galhardo M, Bessa J. Diabetes. 2020 Dec;69(12):2794-2805. doi: 10.2337/db19-1049. Epub 2020 Sep 10. PubMed |
| Leukemia Inhibitory Factor (LIF) Overexpression Increases the Angiogenic Potential of Bone Marrow Mesenchymal Stem/Stromal Cells. Santos GC, Silva DN, Fortuna V, Silveira BM, Orge ID, de Santana TA, Sampaio GL, Paredes BD, Ribeiro-Dos-Santos R, Soares MBP. Front Cell Dev Biol. 2020 Aug 14;8:778. doi: 10.3389/fcell.2020.00778. eCollection 2020. PubMed |
| Primate-restricted KRAB zinc finger proteins and target retrotransposons control gene expression in human neurons. Turelli P, Playfoot C, Grun D, Raclot C, Pontis J, Coudray A, Thorball C, Duc J, Pankevich EV, Deplancke B, Busskamp V, Trono D. Sci Adv. 2020 Aug 28;6(35):eaba3200. doi: 10.1126/sciadv.aba3200. eCollection 2020 Aug. PubMed |
| Protective role of histone deacetylase 4 from ultraviolet radiation-induced DNA lesions. Li S, Zhou M, Ze K, Sun X, Zhao C, Li Z, Lu H, Jiao Y, Wang T, Li S, Hua L, Cai H, Li X. Mol Carcinog. 2020 Nov;59(11):1292-1301. doi: 10.1002/mc.23257. Epub 2020 Sep 13. PubMed |
| Phosphoinositide-dependent Kinase-1 (PDPK1) regulates serum/glucocorticoid-regulated Kinase 3 (SGK3) for prostate cancer cell survival. Nalairndran G, Hassan Abdul Razack A, Mai CW, Fei-Lei Chung F, Chan KK, Hii LW, Lim WM, Chung I, Leong CO. J Cell Mol Med. 2020 Oct;24(20):12188-12198. doi: 10.1111/jcmm.15876. Epub 2020 Sep 14. PubMed |
| LncRNA DSCAM-AS1 interacts with YBX1 to promote cancer progression by forming a positive feedback loop that activates FOXA1 transcription network. Zhang Y, Huang YX, Wang DL, Yang B, Yan HY, Lin LH, Li Y, Chen J, Xie LM, Huang YS, Liao JY, Hu KS, He JH, Saw PE, Xu X, Yin D. Theranostics. 2020 Aug 29;10(23):10823-10837. doi: 10.7150/thno.47830. eCollection 2020. PubMed |
| Trinucleotide Repeat-Targeting dCas9 as a Therapeutic Strategy for Fuchs' Endothelial Corneal Dystrophy. Rong Z, Gong X, Hulleman JD, Corey DR, Mootha VV. Transl Vis Sci Technol. 2020 Aug 31;9(9):47. doi: 10.1167/tvst.9.9.47. eCollection 2020 Aug. PubMed |
HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation.
Magupalli VG, Negro R, Tian Y, Hauenstein AV, Di Caprio G, Skillern W, Deng Q, Orning P, Alam HB, Maliga Z, Sharif H, Hu JJ, Evavold CL, Kagan JC, Schmidt FI, Fitzgerald KA, Kirchhausen T, Li Y, Wu H.
Science. 2020 Sep 18;369(6510). pii: 369/6510/eaas8995. doi: 10.1126/science.aas8995.
PubMed
Associated Plasmids |
| mTOR-mediated cancer drug resistance suppresses autophagy and generates a druggable metabolic vulnerability. Gremke N, Polo P, Dort A, Schneikert J, Elmshauser S, Brehm C, Klingmuller U, Schmitt A, Reinhardt HC, Timofeev O, Wanzel M, Stiewe T. Nat Commun. 2020 Sep 17;11(1):4684. doi: 10.1038/s41467-020-18504-7. PubMed |
| Genome-Scale CRISPR Screening for Regulators of Cell Fate Transitions. Carlini V, Gretarsson KH, Hackett JA. Methods Mol Biol. 2021;2214:91-108. doi: 10.1007/978-1-0716-0958-3_7. PubMed |
| The mechanistic role of alpha-synuclein in the nucleus: impaired nuclear function caused by familial Parkinson's disease SNCA mutations. Chen V, Moncalvo M, Tringali D, Tagliafierro L, Shriskanda A, Ilich E, Dong W, Kantor B, Chiba-Falek O. Hum Mol Genet. 2020 Nov 4;29(18):3107-3121. doi: 10.1093/hmg/ddaa183. PubMed |
| Telomere dysfunction activates YAP1 to drive tissue inflammation. Chakravarti D, Hu B, Mao X, Rashid A, Li J, Li J, Liao WT, Whitley EM, Dey P, Hou P, LaBella KA, Chang A, Wang G, Spring DJ, Deng P, Zhao D, Liang X, Lan Z, Lin Y, Sarkar S, Terranova C, Deribe YL, Blutt SE, Okhuysen P, Zhang J, Vilar E, Nielsen OH, Dupont A, Younes M, Patel KR, Shroyer NF, Rai K, Estes MK, Wang YA, Bertuch AA, DePinho RA. Nat Commun. 2020 Sep 21;11(1):4766. doi: 10.1038/s41467-020-18420-w. PubMed |
| PLRP2 selectively localizes synaptic membrane proteins via acyl-chain remodeling of phospholipids. Kuge H, Miyamoto I, Yagyu KI, Honke K. J Lipid Res. 2020 Dec;61(12):1747-1763. doi: 10.1194/jlr.RA120001087. Epub 2020 Sep 22. PubMed |
| Unique cellular protrusions mediate breast cancer cell migration by tethering to osteogenic cells. Muscarella AM, Dai W, Mitchell PG, Zhang W, Wang H, Jia L, Stossi F, Mancini MA, Chiu W, Zhang XH. NPJ Breast Cancer. 2020 Sep 7;6:42. doi: 10.1038/s41523-020-00183-8. eCollection 2020. PubMed |
| SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2. Clausen TM, Sandoval DR, Spliid CB, Pihl J, Perrett HR, Painter CD, Narayanan A, Majowicz SA, Kwong EM, McVicar RN, Thacker BE, Glass CA, Yang Z, Torres JL, Golden GJ, Bartels PL, Porell RN, Garretson AF, Laubach L, Feldman J, Yin X, Pu Y, Hauser BM, Caradonna TM, Kellman BP, Martino C, Gordts PLSM, Chanda SK, Schmidt AG, Godula K, Leibel SL, Jose J, Corbett KD, Ward AB, Carlin AF, Esko JD. Cell. 2020 Nov 12;183(4):1043-1057.e15. doi: 10.1016/j.cell.2020.09.033. Epub 2020 Sep 14. PubMed |
| FGFR1 Is Critical for RBL2 Loss-Driven Tumor Development and Requires PLCG1 Activation for Continued Growth of Small Cell Lung Cancer. Kim KB, Kim Y, Rivard CJ, Kim DW, Park KS. Cancer Res. 2020 Nov 15;80(22):5051-5062. doi: 10.1158/0008-5472.CAN-20-1453. Epub 2020 Sep 24. PubMed |
| MFSD7C switches mitochondrial ATP synthesis to thermogenesis in response to heme. Li Y, Ivica NA, Dong T, Papageorgiou DP, He Y, Brown DR, Kleyman M, Hu G, Chen WW, Sullivan LB, Del Rosario A, Hammond PT, Vander Heiden MG, Chen J. Nat Commun. 2020 Sep 24;11(1):4837. doi: 10.1038/s41467-020-18607-1. PubMed |
| A new agarose-based microsystem to investigate cell response to prolonged confinement. Prunet A, Lefort S, Delanoe-Ayari H, Laperrousaz B, Simon G, Barentin C, Saci S, Argoul F, Guyot B, Rieu JP, Gobert S, Maguer-Satta V, Riviere C. Lab Chip. 2020 Nov 7;20(21):4016-4030. doi: 10.1039/d0lc00732c. Epub 2020 Sep 25. PubMed |
| Cholesterol Pathway Inhibition Induces TGF-beta Signaling to Promote Basal Differentiation in Pancreatic Cancer. Gabitova-Cornell L, Surumbayeva A, Peri S, Franco-Barraza J, Restifo D, Weitz N, Ogier C, Goldman AR, Hartman TR, Francescone R, Tan Y, Nicolas E, Shah N, Handorf EA, Cai KQ, O'Reilly AM, Sloma I, Chiaverelli R, Moffitt RA, Khazak V, Fang CY, Golemis EA, Cukierman E, Astsaturov I. Cancer Cell. 2020 Oct 12;38(4):567-583.e11. doi: 10.1016/j.ccell.2020.08.015. Epub 2020 Sep 24. PubMed |
| In Vitro Studies to Define the Cell-Surface and Intracellular Targets of Polyarginine-Conjugated Sodium Borocaptate as a Potential Delivery Agent for Boron Neutron Capture Therapy. Fujimura A, Yasui S, Igawa K, Ueda A, Watanabe K, Hanafusa T, Ichikawa Y, Yoshihashi S, Tsuchida K, Kamiya A, Furuya S. Cells. 2020 Sep 23;9(10). pii: cells9102149. doi: 10.3390/cells9102149. PubMed |
| Plasmodium berghei sporozoites in nonreplicative vacuole are eliminated by a PI3P-mediated autophagy-independent pathway. Bindschedler A, Wacker R, Egli J, Eickel N, Schmuckli-Maurer J, Franke-Fayard BM, Janse CJ, Heussler VT. Cell Microbiol. 2021 Jan;23(1):e13271. doi: 10.1111/cmi.13271. Epub 2020 Oct 8. PubMed |
| RPS5 interacts with the rabbit hemorrhagic disease virus 3' extremities region and plays a role in virus replication. Guo H, Zhu J, Miao Q, Qi R, Tang A, Liu C, Yang H, Yuan L, Liu G. Vet Microbiol. 2020 Oct;249:108858. doi: 10.1016/j.vetmic.2020.108858. Epub 2020 Sep 18. PubMed |
| NFIA differentially controls adipogenic and myogenic gene program through distinct pathways to ensure brown and beige adipocyte differentiation. Hiraike Y, Waki H, Miyake K, Wada T, Oguchi M, Saito K, Tsutsumi S, Aburatani H, Yamauchi T, Kadowaki T. PLoS Genet. 2020 Sep 29;16(9):e1009044. doi: 10.1371/journal.pgen.1009044. eCollection 2020 Sep. PubMed |
Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant.
Yurkovetskiy L, Wang X, Pascal KE, Tomkins-Tinch C, Nyalile TP, Wang Y, Baum A, Diehl WE, Dauphin A, Carbone C, Veinotte K, Egri SB, Schaffner SF, Lemieux JE, Munro JB, Rafique A, Barve A, Sabeti PC, Kyratsous CA, Dudkina NV, Shen K, Luban J.
Cell. 2020 Sep 15. pii: S0092-8674(20)31229-0. doi: 10.1016/j.cell.2020.09.032.
PubMed
Associated Plasmids |
| Protocol for Designing Small-Molecule-Regulated Destabilizing Domains for In Vitro Use. Ramadurgum P, Hulleman JD. STAR Protoc. 2020 Sep 18;1(2). doi: 10.1016/j.xpro.2020.100069. Epub 2020 Jul 24. PubMed |
| MYC Promotes Bone Marrow Stem Cell Dysfunction in Fanconi Anemia. Rodriguez A, Zhang K, Farkkila A, Filiatrault J, Yang C, Velazquez M, Furutani E, Goldman DC, Garcia de Teresa B, Garza-Mayen G, McQueen K, Sambel LA, Molina B, Torres L, Gonzalez M, Vadillo E, Pelayo R, Fleming WH, Grompe M, Shimamura A, Hautaniemi S, Greenberger J, Frias S, Parmar K, D'Andrea AD. Cell Stem Cell. 2021 Jan 7;28(1):33-47.e8. doi: 10.1016/j.stem.2020.09.004. Epub 2020 Sep 29. PubMed |
| Identification of Cx45 as a Major Component of GJs in HeLa Cells. Choi EJ, Palacios-Prado N, Saez JC, Lee J. Biomolecules. 2020 Sep 29;10(10). pii: biom10101389. doi: 10.3390/biom10101389. PubMed |
| The DNA damage response links human squamous proliferation with differentiation. Molinuevo R, Freije A, Contreras L, Sanz JR, Gandarillas A. J Cell Biol. 2020 Nov 2;219(11):e202001063. doi: 10.1083/jcb.202001063. PubMed |
| ISG15 Connects Autophagy and IFN-gamma-Dependent Control of Toxoplasma gondii Infection in Human Cells. Bhushan J, Radke JB, Perng YC, Mcallaster M, Lenschow DJ, Virgin HW, Sibley LD. mBio. 2020 Oct 6;11(5). pii: mBio.00852-20. doi: 10.1128/mBio.00852-20. PubMed |
| A system-level approach identifies HIF-2alpha as a critical regulator of chondrosarcoma progression. Kim H, Cho Y, Kim HS, Kang D, Cheon D, Kim YJ, Chang MJ, Lee KM, Chang CB, Kang SB, Kang HG, Kim JH. Nat Commun. 2020 Oct 6;11(1):5023. doi: 10.1038/s41467-020-18817-7. PubMed |
| TNFR2 is required for RIP1-dependent cell death in human leukemia. Aguade-Gorgorio J, McComb S, Eckert C, Guinot A, Marovca B, Mezzatesta C, Jenni S, Abduli L, Schrappe M, Dobay MP, Stanulla M, von Stackelberg A, Cario G, Bourquin JP, Bornhauser BC. Blood Adv. 2020 Oct 13;4(19):4823-4833. doi: 10.1182/bloodadvances.2019000796. PubMed |
| MED19 Regulates Adipogenesis and Maintenance of White Adipose Tissue Mass by Mediating PPARgamma-Dependent Gene Expression. Dean JM, He A, Tan M, Wang J, Lu D, Razani B, Lodhi IJ. Cell Rep. 2020 Oct 6;33(1):108228. doi: 10.1016/j.celrep.2020.108228. PubMed |
| Respiratory Supercomplexes Promote Mitochondrial Efficiency and Growth in Severely Hypoxic Pancreatic Cancer. Hollinshead KER, Parker SJ, Eapen VV, Encarnacion-Rosado J, Sohn A, Oncu T, Cammer M, Mancias JD, Kimmelman AC. Cell Rep. 2020 Oct 6;33(1):108231. doi: 10.1016/j.celrep.2020.108231. PubMed |
| In vivo CRISPR/Cas9 targeting of fusion oncogenes for selective elimination of cancer cells. Martinez-Lage M, Torres-Ruiz R, Puig-Serra P, Moreno-Gaona P, Martin MC, Moya FJ, Quintana-Bustamante O, Garcia-Silva S, Carcaboso AM, Petazzi P, Bueno C, Mora J, Peinado H, Segovia JC, Menendez P, Rodriguez-Perales S. Nat Commun. 2020 Oct 8;11(1):5060. doi: 10.1038/s41467-020-18875-x. PubMed |
| Identification of a dynamic gene regulatory network required for pluripotency factor-induced reprogramming of mouse fibroblasts and hepatocytes. Papathanasiou M, Tsiftsoglou SA, Polyzos AP, Papadopoulou D, Valakos D, Klagkou E, Karagianni P, Pliatska M, Talianidis I, Agelopoulos M, Thanos D. EMBO J. 2021 Jan 4;40(1):e102236. doi: 10.15252/embj.2019102236. Epub 2020 Oct 9. PubMed |
| Efficacy of the novel tubulin polymerization inhibitor PTC-028 for myelodysplastic syndrome. Zhong C, Kayamori K, Koide S, Shinoda D, Oshima M, Nakajima-Takagi Y, Nagai Y, Mimura N, Sakaida E, Yamazaki S, Iwano S, Miyawaki A, Ito R, Tohyama K, Yamaguchi K, Furukawa Y, Lennox W, Sheedy J, Weetall M, Iwama A. Cancer Sci. 2020 Dec;111(12):4336-4347. doi: 10.1111/cas.14684. Epub 2020 Nov 2. PubMed |
| Time-Resolved Profiling Reveals ATF3 as a Novel Mediator of Endocrine Resistance in Breast Cancer. Borgoni S, Sofyali E, Soleimani M, Wilhelm H, Muller-Decker K, Will R, Noronha A, Beumers L, Verschure PJ, Yarden Y, Magnani L, van Kampen AHC, Moerland PD, Wiemann S. Cancers (Basel). 2020 Oct 11;12(10). pii: cancers12102918. doi: 10.3390/cancers12102918. PubMed |
| MLLT6 maintains PD-L1 expression and mediates tumor immune resistance. Sreevalsan S, Doring M, Paszkowski-Rogacz M, Brux M, Blanck C, Meyer M, Momburg F, Buchholz F, Theis M. EMBO Rep. 2020 Dec 3;21(12):e50155. doi: 10.15252/embr.202050155. Epub 2020 Oct 15. PubMed |
| Generation of a cost-effective cell line for support of high-throughput isolation of primary human B cells and monoclonal neutralizing antibodies. Whaley RE, Ameny S, Arkatkar T, Seese A, Wall A, Khan I, Carter JJ, Scherer EM, Rawlings DJ, Galloway DA, McElrath MJ, Cohen KW, McGuire AT. J Immunol Methods. 2021 Jan;488:112901. doi: 10.1016/j.jim.2020.112901. Epub 2020 Oct 15. PubMed |
| Functional role of the long noncoding RNA X-inactive specific transcript in leiomyoma pathogenesis. Chuang TD, Rehan A, Khorram O. Fertil Steril. 2021 Jan;115(1):238-247. doi: 10.1016/j.fertnstert.2020.07.024. Epub 2020 Oct 15. PubMed |
| The Human-Specific STING Agonist G10 Activates Type I Interferon and the NLRP3 Inflammasome in Porcine Cells. Ming SL, Zeng L, Guo YK, Zhang S, Li GL, Ma YX, Zhai YY, Chang WR, Yang L, Wang J, Yang GY, Chu BB. Front Immunol. 2020 Sep 24;11:575818. doi: 10.3389/fimmu.2020.575818. eCollection 2020. PubMed |
| Burst mitofusin activation reverses neuromuscular dysfunction in murine CMT2A. Franco A, Dang X, Walton EK, Ho JN, Zablocka B, Ly C, Miller TM, Baloh RH, Shy ME, Yoo AS, Dorn GW 2nd. Elife. 2020 Oct 19;9. pii: 61119. doi: 10.7554/eLife.61119. PubMed |
| Contribution of GATA6 to homeostasis of the human upper pilosebaceous unit and acne pathogenesis. Oules B, Philippeos C, Segal J, Tihy M, Vietri Rudan M, Cujba AM, Grange PA, Quist S, Natsuga K, Deschamps L, Dupin N, Donati G, Watt FM. Nat Commun. 2020 Oct 20;11(1):5067. doi: 10.1038/s41467-020-18784-z. PubMed |
| Enhancer Reprogramming Confers Dependence on Glycolysis and IGF Signaling in KMT2D Mutant Melanoma. Maitituoheti M, Keung EZ, Tang M, Yan L, Alam H, Han G, Singh AK, Raman AT, Terranova C, Sarkar S, Orouji E, Amin SB, Sharma S, Williams M, Samant NS, Dhamdhere M, Zheng N, Shah T, Shah A, Axelrad JB, Anvar NE, Lin YH, Jiang S, Chang EQ, Ingram DR, Wang WL, Lazar A, Lee MG, Muller F, Wang L, Ying H, Rai K. Cell Rep. 2020 Oct 20;33(3):108293. doi: 10.1016/j.celrep.2020.108293. PubMed |
| PLA2G6 guards placental trophoblasts against ferroptotic injury. Beharier O, Tyurin VA, Goff JP, Guerrero-Santoro J, Kajiwara K, Chu T, Tyurina YY, St Croix CM, Wallace CT, Parry S, Parks WT, Kagan VE, Sadovsky Y. Proc Natl Acad Sci U S A. 2020 Nov 3;117(44):27319-27328. doi: 10.1073/pnas.2009201117. Epub 2020 Oct 21. PubMed |
| XBP1 increases transactivation of somatic mutants of ESR1 and loss of XBP1 reverses endocrine resistance conferred by gain-of-function Y537S ESR1 mutation. Barua D, Abbasi B, Gupta A, Gupta S. Heliyon. 2020 Oct 10;6(10):e05217. doi: 10.1016/j.heliyon.2020.e05217. eCollection 2020 Oct. PubMed |
| Phosphoinositide 3'-Kinase gamma Facilitates Polyomavirus Infection. Clark P, Gee GV, Albright BS, Assetta B, Han Y, Atwood WJ, DiMaio D. Viruses. 2020 Oct 20;12(10). pii: v12101190. doi: 10.3390/v12101190. PubMed |
Metabolic plasticity of IDH1-mutant glioma cell lines is responsible for low sensitivity to glutaminase inhibition.
Ruiz-Rodado V, Lita A, Dowdy T, Celiku O, Saldana AC, Wang H, Yang CZ, Chari R, Li A, Zhang W, Song H, Zhang M, Ahn S, Davis D, Chen X, Zhuang Z, Herold-Mende C, Walters KJ, Gilbert MR, Larion M.
Cancer Metab. 2020 Oct 21;8:23. doi: 10.1186/s40170-020-00229-2. eCollection 2020.
PubMed
Associated Plasmids |
| CBP80/20-dependent translation initiation factor (CTIF) inhibits HIV-1 Gag synthesis by targeting the function of the viral protein Rev. Garcia-de-Gracia F, Gaete-Argel A, Riquelme-Barrios S, Pereira-Montecinos C, Rojas-Araya B, Aguilera P, Oyarzun-Arrau A, Rojas-Fuentes C, Acevedo ML, Chnaiderman J, Valiente-Echeverria F, Toro-Ascuy D, Soto-Rifo R. RNA Biol. 2021 May;18(5):745-758. doi: 10.1080/15476286.2020.1832375. Epub 2020 Oct 25. PubMed |
| SHOC2 Is a Critical Modulator of Sensitivity to EGFR-TKIs in Non-Small Cell Lung Cancer Cells. Terai H, Hamamoto J, Emoto K, Masuda T, Manabe T, Kuronuma S, Kobayashi K, Masuzawa K, Ikemura S, Nakayama S, Kawada I, Suzuki Y, Takeuchi O, Suzuki Y, Ohtsuki S, Yasuda H, Soejima K, Fukunaga K. Mol Cancer Res. 2021 Feb;19(2):317-328. doi: 10.1158/1541-7786.MCR-20-0664. Epub 2020 Oct 26. PubMed |
| ABRO1 stabilizes the deubiquitinase BRCC3 through inhibiting its degradation mediated by the E3 ubiquitin ligase WWP2. Zhang W, Tao SS, Wang T, Zhang J, Liu X, Li YT, Chen H, Zhan YQ, Yu M, Ge CH, Li CY, Ren GM, Yang XM, Yin RH. FEBS Lett. 2021 Jan;595(2):169-182. doi: 10.1002/1873-3468.13970. Epub 2020 Nov 8. PubMed |
| Activation of Clustered IFNgamma Target Genes Drives Cohesin-Controlled Transcriptional Memory. Siwek W, Tehrani SSH, Mata JF, Jansen LET. Mol Cell. 2020 Nov 5;80(3):396-409.e6. doi: 10.1016/j.molcel.2020.10.005. Epub 2020 Oct 26. PubMed |
| ATF4 links ER stress with reticulophagy in glioblastoma cells. Zielke S, Kardo S, Zein L, Mari M, Covarrubias-Pinto A, Kinzler MN, Meyer N, Stolz A, Fulda S, Reggiori F, Kogel D, van Wijk S. Autophagy. 2021 Sep;17(9):2432-2448. doi: 10.1080/15548627.2020.1827780. Epub 2020 Oct 28. PubMed |
| Targeting Subtype-Specific Metabolic Preferences in Nucleotide Biosynthesis Inhibits Tumor Growth in a Breast Cancer Model. Ogrodzinski MP, Teoh ST, Lunt SY. Cancer Res. 2021 Jan 15;81(2):303-314. doi: 10.1158/0008-5472.CAN-20-1666. Epub 2020 Oct 28. PubMed |
| Multiplexed tat-Targeting CRISPR-Cas9 Protects T Cells from Acute HIV-1 Infection with Inhibition of Viral Escape. Ophinni Y, Miki S, Hayashi Y, Kameoka M. Viruses. 2020 Oct 28;12(11). pii: v12111223. doi: 10.3390/v12111223. PubMed |
| Netrin G1 Promotes Pancreatic Tumorigenesis through Cancer-Associated Fibroblast-Driven Nutritional Support and Immunosuppression. Francescone R, Barbosa Vendramini-Costa D, Franco-Barraza J, Wagner J, Muir A, Lau AN, Gabitova L, Pazina T, Gupta S, Luong T, Rollins D, Malik R, Thapa RJ, Restifo D, Zhou Y, Cai KQ, Hensley HH, Tan Y, Kruger WD, Devarajan K, Balachandran S, Klein-Szanto AJ, Wang H, El-Deiry WS, Vander Heiden MG, Peri S, Campbell KS, Astsaturov I, Cukierman E. Cancer Discov. 2021 Feb;11(2):446-479. doi: 10.1158/2159-8290.CD-20-0775. Epub 2020 Oct 30. PubMed |
| Orthogonal SARS-CoV-2 Serological Assays Enable Surveillance of Low-Prevalence Communities and Reveal Durable Humoral Immunity. Ripperger TJ, Uhrlaub JL, Watanabe M, Wong R, Castaneda Y, Pizzato HA, Thompson MR, Bradshaw C, Weinkauf CC, Bime C, Erickson HL, Knox K, Bixby B, Parthasarathy S, Chaudhary S, Natt B, Cristan E, El Aini T, Rischard F, Campion J, Chopra M, Insel M, Sam A, Knepler JL, Capaldi AP, Spier CM, Dake MD, Edwards T, Kaplan ME, Scott SJ, Hypes C, Mosier J, Harris DT, LaFleur BJ, Sprissler R, Nikolich-Zugich J, Bhattacharya D. Immunity. 2020 Nov 17;53(5):925-933.e4. doi: 10.1016/j.immuni.2020.10.004. Epub 2020 Oct 14. PubMed |
| Circular RNA circTP63 enhances estrogen receptor-positive breast cancer progression and malignant behaviors through the miR-873-3p/FOXM1 axis. Deng Y, Xia J, Xu YE. Anticancer Drugs. 2021 Jan 1;32(1):44-52. doi: 10.1097/CAD.0000000000001010. PubMed |
| Broad genic repression domains signify enhanced silencing of oncogenes. Zhao D, Zhang L, Zhang M, Xia B, Lv J, Gao X, Wang G, Meng Q, Yi Y, Zhu S, Tomoiaga AS, Lee MG, Cooke JP, Cao Q, Chen K. Nat Commun. 2020 Nov 3;11(1):5560. doi: 10.1038/s41467-020-18913-8. PubMed |
Genome-wide CRISPR Screens Reveal Host Factors Critical for SARS-CoV-2 Infection.
Wei J, Alfajaro MM, DeWeirdt PC, Hanna RE, Lu-Culligan WJ, Cai WL, Strine MS, Zhang SM, Graziano VR, Schmitz CO, Chen JS, Mankowski MC, Filler RB, Ravindra NG, Gasque V, de Miguel FJ, Patil A, Chen H, Oguntuyo KY, Abriola L, Surovtseva YV, Orchard RC, Lee B, Lindenbach BD, Politi K, van Dijk D, Kadoch C, Simon MD, Yan Q, Doench JG, Wilen CB.
Cell. 2021 Jan 7;184(1):76-91.e13. doi: 10.1016/j.cell.2020.10.028. Epub 2020 Oct 20.
PubMed
Associated Plasmids |
Identification of Required Host Factors for SARS-CoV-2 Infection in Human Cells.
Daniloski Z, Jordan TX, Wessels HH, Hoagland DA, Kasela S, Legut M, Maniatis S, Mimitou EP, Lu L, Geller E, Danziger O, Rosenberg BR, Phatnani H, Smibert P, Lappalainen T, tenOever BR, Sanjana NE.
Cell. 2020 Oct 24. pii: S0092-8674(20)31394-5. doi: 10.1016/j.cell.2020.10.030.
PubMed
Associated Plasmids |
ZNF354C is a transcriptional repressor that inhibits endothelial angiogenic sprouting.
Oo JA, Irmer B, Gunther S, Warwick T, Palfi K, Izquierdo Ponce J, Teichmann T, Pfluger-Muller B, Gilsbach R, Brandes RP, Leisegang MS.
Sci Rep. 2020 Nov 5;10(1):19079. doi: 10.1038/s41598-020-76193-0.
PubMed
Associated Plasmids |
| Effective screening of SARS-CoV-2 neutralizing antibodies in patient serum using lentivirus particles pseudotyped with SARS-CoV-2 spike glycoprotein. Tandon R, Mitra D, Sharma P, McCandless MG, Stray SJ, Bates JT, Marshall GD. Sci Rep. 2020 Nov 5;10(1):19076. doi: 10.1038/s41598-020-76135-w. PubMed |
| Proteasome-Bound UCH37/UCHL5 Debranches Ubiquitin Chains to Promote Degradation. Deol KK, Crowe SO, Du J, Bisbee HA, Guenette RG, Strieter ER. Mol Cell. 2020 Dec 3;80(5):796-809.e9. doi: 10.1016/j.molcel.2020.10.017. Epub 2020 Nov 5. PubMed |
| Genetically Defined Syngeneic Mouse Models of Ovarian Cancer as Tools for the Discovery of Combination Immunotherapy. Iyer S, Zhang S, Yucel S, Horn H, Smith SG, Reinhardt F, Hoefsmit E, Assatova B, Casado J, Meinsohn MC, Barrasa MI, Bell GW, Perez-Villatoro F, Huhtinen K, Hynninen J, Oikkonen J, Galhenage PM, Pathania S, Hammond PT, Neel BG, Farkkila A, Pepin D, Weinberg RA. Cancer Discov. 2021 Feb;11(2):384-407. doi: 10.1158/2159-8290.CD-20-0818. Epub 2020 Nov 6. PubMed |
| CRISPR-Cas9-mediated knockout of GCN2 reveals a critical role in sensing amino acid deprivation in bovine mammary epithelial cells. Edick AM, Audette J, Burgos SA. J Dairy Sci. 2021 Jan;104(1):1123-1135. doi: 10.3168/jds.2020-18700. Epub 2020 Nov 6. PubMed |
| CEBPG promotes esophageal squamous cell carcinoma progression by enhancing PI3K-AKT signaling. Huang Y, Lin L, Shen Z, Li Y, Cao H, Peng L, Qiu Y, Cheng X, Meng M, Lu D, Yin D. Am J Cancer Res. 2020 Oct 1;10(10):3328-3344. eCollection 2020. PubMed |
| Role of Tissue Transglutaminase Catalytic and Guanosine Triphosphate-Binding Domains in Renal Cell Carcinoma Progression. Ulukan B, Bihorac A, Sipahioglu T, Kiraly R, Fesus L, Telci D. ACS Omega. 2020 Oct 20;5(43):28273-28284. doi: 10.1021/acsomega.0c04226. eCollection 2020 Nov 3. PubMed |
| Regulation of PD-L1 expression in K-ras-driven cancers through ROS-mediated FGFR1 signaling. Glorieux C, Xia X, He YQ, Hu Y, Cremer K, Robert A, Liu J, Wang F, Ling J, Chiao PJ, Huang P. Redox Biol. 2021 Jan;38:101780. doi: 10.1016/j.redox.2020.101780. Epub 2020 Nov 3. PubMed |
| An endoribonuclease-based feedforward controller for decoupling resource-limited genetic modules in mammalian cells. Jones RD, Qian Y, Siciliano V, DiAndreth B, Huh J, Weiss R, Del Vecchio D. Nat Commun. 2020 Nov 10;11(1):5690. doi: 10.1038/s41467-020-19126-9. PubMed |
| Decoding myofibroblast origins in human kidney fibrosis. Kuppe C, Ibrahim MM, Kranz J, Zhang X, Ziegler S, Perales-Paton J, Jansen J, Reimer KC, Smith JR, Dobie R, Wilson-Kanamori JR, Halder M, Xu Y, Kabgani N, Kaesler N, Klaus M, Gernhold L, Puelles VG, Huber TB, Boor P, Menzel S, Hoogenboezem RM, Bindels EMJ, Steffens J, Floege J, Schneider RK, Saez-Rodriguez J, Henderson NC, Kramann R. Nature. 2021 Jan;589(7841):281-286. doi: 10.1038/s41586-020-2941-1. Epub 2020 Nov 11. PubMed |
| Human Cytomegalovirus Interactions with the Basement Membrane Protein Nidogen 1. Kuan MI, Jaeger HK, Balemba OB, O'Dowd JM, Duricka D, Hannemann H, Marx E, Teissier N, Gabrielli L, Bonasoni MP, Keithley EM, Fortunato EA. J Virol. 2021 Jan 13;95(3). pii: JVI.01506-20. doi: 10.1128/JVI.01506-20. Print 2021 Jan 13. PubMed |
| Genome-Wide CRISPR-Cas9 Screen Reveals the Importance of the Heparan Sulfate Pathway and the Conserved Oligomeric Golgi Complex for Synthetic Double-Stranded RNA Uptake and Sindbis Virus Infection. Petitjean O, Girardi E, Ngondo RP, Lupashin V, Pfeffer S. mSphere. 2020 Nov 11;5(6). pii: 5/6/e00914-20. doi: 10.1128/mSphere.00914-20. PubMed |
| A versatile oblique plane microscope for large-scale and high-resolution imaging of subcellular dynamics. Sapoznik E, Chang BJ, Huh J, Ju RJ, Azarova EV, Pohlkamp T, Welf ES, Broadbent D, Carisey AF, Stehbens SJ, Lee KM, Marin A, Hanker AB, Schmidt JC, Arteaga CL, Yang B, Kobayashi Y, Tata PR, Kruithoff R, Doubrovinski K, Shepherd DP, Millett-Sikking A, York AG, Dean KM, Fiolka RP. Elife. 2020 Nov 12;9. pii: 57681. doi: 10.7554/eLife.57681. PubMed |
| Ubiquitination and the proteasome rather than caspase-3-mediated C-terminal cleavage are involved in the EAAT2 degradation by staurosporine-induced cellular stress. Voss TD, Gerget M, Linkus B, von Einem B, Landwehrmeyer GB, Lewerenz J. J Neurochem. 2021 May;157(4):1284-1299. doi: 10.1111/jnc.15237. Epub 2020 Dec 3. PubMed |
| A conserved acetylation switch enables pharmacological control of tubby-like protein stability. Kerek EM, Yoon KH, Luo SY, Chen J, Valencia R, Julien O, Waskiewicz AJ, Hubbard BP. J Biol Chem. 2021 Jan-Jun;296:100073. doi: 10.1074/jbc.RA120.015839. Epub 2020 Nov 23. PubMed |
| A regulatory element in the 3'-untranslated region of CEBPA is associated with myeloid/NK/T-cell leukemia. Kimura Y, Iwanaga E, Iwanaga K, Endo S, Inoue Y, Tokunaga K, Nagahata Y, Masuda K, Kawamoto H, Matsuoka M. Eur J Haematol. 2021 Mar;106(3):327-339. doi: 10.1111/ejh.13551. Epub 2020 Nov 29. PubMed |
| Loss of HCRP1 leads to upregulation of PD-L1 via STAT3 activation and is of prognostic significance in EGFR-dependent cancer. Tomasich E, Topakian T, Heller G, Udovica S, Krainer M, Marhold M. Transl Res. 2021 Apr;230:21-33. doi: 10.1016/j.trsl.2020.11.005. Epub 2020 Nov 13. PubMed |
| Mutations in GRK2 cause Jeune syndrome by impairing Hedgehog and canonical Wnt signaling. Bosakova M, Abraham SP, Nita A, Hruba E, Buchtova M, Taylor SP, Duran I, Martin J, Svozilova K, Barta T, Varecha M, Balek L, Kohoutek J, Radaszkiewicz T, Pusapati GV, Bryja V, Rush ET, Thiffault I, Nickerson DA, Bamshad MJ, Rohatgi R, Cohn DH, Krakow D, Krejci P. EMBO Mol Med. 2020 Nov 6;12(11):e11739. doi: 10.15252/emmm.201911739. Epub 2020 Oct 14. PubMed |
| Requisite Chromatin Remodeling for Myeloid and Erythroid Lineage Differentiation from Erythromyeloid Progenitors. Wu J, Krchma K, Lee HJ, Prabhakar S, Wang X, Zhao H, Xing X, Seong RH, Fremont DH, Artyomov MN, Wang T, Choi K. Cell Rep. 2020 Nov 17;33(7):108395. doi: 10.1016/j.celrep.2020.108395. PubMed |
| Protein Prenylation Drives Discrete Signaling Programs for the Differentiation and Maintenance of Effector Treg Cells. Su W, Chapman NM, Wei J, Zeng H, Dhungana Y, Shi H, Saravia J, Zhou P, Long L, Rankin S, Kc A, Vogel P, Chi H. Cell Metab. 2020 Dec 1;32(6):996-1011.e7. doi: 10.1016/j.cmet.2020.10.022. Epub 2020 Nov 17. PubMed |
| Calcineurin phosphatase activity regulates Varicella-Zoster Virus induced cell-cell fusion. Zhou M, Kamarshi V, Arvin AM, Oliver SL. PLoS Pathog. 2020 Nov 20;16(11):e1009022. doi: 10.1371/journal.ppat.1009022. eCollection 2020 Nov. PubMed |
| Stabilization of ERK-Phosphorylated METTL3 by USP5 Increases m(6)A Methylation. Sun HL, Zhu AC, Gao Y, Terajima H, Fei Q, Liu S, Zhang L, Zhang Z, Harada BT, He YY, Bissonnette MB, Hung MC, He C. Mol Cell. 2020 Nov 19;80(4):633-647.e7. doi: 10.1016/j.molcel.2020.10.026. PubMed |
| Phosphorylation of the RB C-terminus regulates condensin II release from chromatin. Kim SJ, MacDonald JI, Dick FA. J Biol Chem. 2021 Jan-Jun;296:100108. doi: 10.1074/jbc.RA120.016511. Epub 2020 Dec 3. PubMed |
| HTCC as a Polymeric Inhibitor of SARS-CoV-2 and MERS-CoV. Milewska A, Chi Y, Szczepanski A, Barreto-Duran E, Dabrowska A, Botwina P, Obloza M, Liu K, Liu D, Guo X, Ge Y, Li J, Cui L, Ochman M, Urlik M, Rodziewicz-Motowidlo S, Zhu F, Szczubialka K, Nowakowska M, Pyrc K. J Virol. 2021 Jan 28;95(4). pii: JVI.01622-20. doi: 10.1128/JVI.01622-20. Print 2021 Jan 28. PubMed |
| Mutations in Spliceosomal Genes PPIL1 and PRP17 Cause Neurodegenerative Pontocerebellar Hypoplasia with Microcephaly. Chai G, Webb A, Li C, Antaki D, Lee S, Breuss MW, Lang N, Stanley V, Anzenberg P, Yang X, Marshall T, Gaffney P, Wierenga KJ, Chung BH, Tsang MH, Pais LS, Lovgren AK, VanNoy GE, Rehm HL, Mirzaa G, Leon E, Diaz J, Neumann A, Kalverda AP, Manfield IW, Parry DA, Logan CV, Johnson CA, Bonthron DT, Valleley EMA, Issa MY, Abdel-Ghafar SF, Abdel-Hamid MS, Jennings P, Zaki MS, Sheridan E, Gleeson JG. Neuron. 2021 Jan 20;109(2):241-256.e9. doi: 10.1016/j.neuron.2020.10.035. Epub 2020 Nov 20. PubMed |
| Integrative analysis reveals novel driver genes and molecular subclasses of hepatocellular carcinoma. Yang L, Zhang Z, Sun Y, Pang S, Yao Q, Lin P, Cheng J, Li J, Ding G, Hui L, Li Y, Li H. Aging (Albany NY). 2020 Nov 20;12(23):23849-23871. doi: 10.18632/aging.104047. Epub 2020 Nov 20. PubMed |
| Receptor-mediated clustering of FIP200 bypasses the role of LC3 lipidation in autophagy. Ohnstad AE, Delgado JM, North BJ, Nasa I, Kettenbach AN, Schultz SW, Shoemaker CJ. EMBO J. 2020 Dec 15;39(24):e104948. doi: 10.15252/embj.2020104948. Epub 2020 Nov 23. PubMed |
| Reprogramming Human Fibroblasts to Induced Pluripotent Stem Cells Using the GFP-Marked Lentiviral Vectors in the Chemically Defined Medium. Shao Z, Cevallos RR, Hu K. Methods Mol Biol. 2021;2239:101-116. doi: 10.1007/978-1-0716-1084-8_7. PubMed |
| Genome-scale CRISPR screening at high sensitivity with an empirically designed sgRNA library. Henkel L, Rauscher B, Schmitt B, Winter J, Boutros M. BMC Biol. 2020 Nov 23;18(1):174. doi: 10.1186/s12915-020-00905-1. PubMed |
| Targeted intracellular degradation of SARS-CoV-2 via computationally optimized peptide fusions. Chatterjee P, Ponnapati M, Kramme C, Plesa AM, Church GM, Jacobson JM. Commun Biol. 2020 Nov 23;3(1):715. doi: 10.1038/s42003-020-01470-7. PubMed |
| Optical quantification of intracellular mass density and cell mechanics in 3D mechanical confinement. Bakhshandeh S, Taieb HM, Schlussler R, Kim K, Beck T, Taubenberger A, Guck J, Cipitria A. Soft Matter. 2021 Jan 28;17(4):853-862. doi: 10.1039/d0sm01556c. Epub 2020 Nov 24. PubMed |
| A Quantitative Live-Cell Superresolution Imaging Framework for Measuring the Mobility of Single Molecules at Sites of Virus Assembly. Groves NS, Bruns MM, van Engelenburg SB. Pathogens. 2020 Nov 21;9(11). pii: pathogens9110972. doi: 10.3390/pathogens9110972. PubMed |
| Kallikrein 13 serves as a priming protease during infection by the human coronavirus HKU1. Milewska A, Falkowski K, Kulczycka M, Bielecka E, Naskalska A, Mak P, Lesner A, Ochman M, Urlik M, Diamandis E, Prassas I, Potempa J, Kantyka T, Pyrc K. Sci Signal. 2020 Nov 24;13(659). pii: 13/659/eaba9902. doi: 10.1126/scisignal.aba9902. PubMed |
| BCCIP is required for nucleolar recruitment of eIF6 and 12S pre-rRNA production during 60S ribosome biogenesis. Ye C, Liu B, Lu H, Liu J, Rabson AB, Jacinto E, Pestov DG, Shen Z. Nucleic Acids Res. 2020 Dec 16;48(22):12817-12832. doi: 10.1093/nar/gkaa1114. PubMed |
| Relative expression of KLK5 to LEKTI is associated with aggressiveness of oral squamous cell carcinoma. Alves MG, Kodama MH, da Silva EZM, Gomes BBM, da Silva RAA, Vieira GV, Alves VM, da Fonseca CK, Santana AC, Cecilio NT, Costa MSA, Jamur MC, Oliver C, Cunha TM, Bugge TH, Braz-Silva PH, Colli LM, Sales KU. Transl Oncol. 2021 Jan;14(1):100970. doi: 10.1016/j.tranon.2020.100970. Epub 2020 Nov 28. PubMed |
| A macrophage-specific lncRNA regulates apoptosis and atherosclerosis by tethering HuR in the nucleus. Simion V, Zhou H, Haemmig S, Pierce JB, Mendes S, Tesmenitsky Y, Perez-Cremades D, Lee JF, Chen AF, Ronda N, Papotti B, Marto JA, Feinberg MW. Nat Commun. 2020 Dec 1;11(1):6135. doi: 10.1038/s41467-020-19664-2. PubMed |
| Master Regulators and Cofactors of Human Neuronal Cell Fate Specification Identified by CRISPR Gene Activation Screens. Black JB, McCutcheon SR, Dube S, Barrera A, Klann TS, Rice GA, Adkar SS, Soderling SH, Reddy TE, Gersbach CA. Cell Rep. 2020 Dec 1;33(9):108460. doi: 10.1016/j.celrep.2020.108460. PubMed |
| A brainstem peptide system activated at birth protects postnatal breathing. Shi Y, Stornetta DS, Reklow RJ, Sahu A, Wabara Y, Nguyen A, Li K, Zhang Y, Perez-Reyes E, Ross RA, Lowell BB, Stornetta RL, Funk GD, Guyenet PG, Bayliss DA. Nature. 2021 Jan;589(7842):426-430. doi: 10.1038/s41586-020-2991-4. Epub 2020 Dec 2. PubMed |
| CRISPR screen identifies genes that sensitize AML cells to double-negative T-cell therapy. Soares F, Chen B, Lee JB, Ahmed M, Ly D, Tin E, Kang H, Zeng Y, Akhtar N, Minden MD, He HH, Zhang L. Blood. 2021 Apr 22;137(16):2171-2181. doi: 10.1182/blood.2019004108. PubMed |
| Genome-wide Screens Identify Lineage- and Tumor-Specific Genes Modulating MHC-I- and MHC-II-Restricted Immunosurveillance of Human Lymphomas. Dersh D, Phelan JD, Gumina ME, Wang B, Arbuckle JH, Holly J, Kishton RJ, Markowitz TE, Seedhom MO, Fridlyand N, Wright GW, Huang DW, Ceribelli M, Thomas CJ, Lack JB, Restifo NP, Kristie TM, Staudt LM, Yewdell JW. Immunity. 2021 Jan 12;54(1):116-131.e10. doi: 10.1016/j.immuni.2020.11.002. Epub 2020 Dec 2. PubMed |
| Revealing Temozolomide Resistance Mechanisms via Genome-Wide CRISPR Libraries. Rocha CRR, Reily Rocha A, Molina Silva M, Rodrigues Gomes L, Teatin Latancia M, Andrade Tomaz M, de Souza I, Karolynne Seregni Monteiro L, Menck CFM. Cells. 2020 Dec 1;9(12). pii: cells9122573. doi: 10.3390/cells9122573. PubMed |
| Nanoparticle Vaccines Based on the Receptor Binding Domain (RBD) and Heptad Repeat (HR) of SARS-CoV-2 Elicit Robust Protective Immune Responses. Ma X, Zou F, Yu F, Li R, Yuan Y, Zhang Y, Zhang X, Deng J, Chen T, Song Z, Qiao Y, Zhan Y, Liu J, Zhang J, Zhang X, Peng Z, Li Y, Lin Y, Liang L, Wang G, Chen Y, Chen Q, Pan T, He X, Zhang H. Immunity. 2020 Dec 15;53(6):1315-1330.e9. doi: 10.1016/j.immuni.2020.11.015. Epub 2020 Nov 25. PubMed |
| Pharmacologic Screening Identifies Metabolic Vulnerabilities of CD8(+) T Cells. Drijvers JM, Gillis JE, Muijlwijk T, Nguyen TH, Gaudiano EF, Harris IS, LaFleur MW, Ringel AE, Yao CH, Kurmi K, Juneja VR, Trombley JD, Haigis MC, Sharpe AH. Cancer Immunol Res. 2021 Feb;9(2):184-199. doi: 10.1158/2326-6066.CIR-20-0384. Epub 2020 Dec 4. PubMed |
| Oligodendroglial glycolytic stress triggers inflammasome activation and neuropathology in Alzheimer's disease. Zhang X, Wang R, Hu D, Sun X, Fujioka H, Lundberg K, Chan ER, Wang Q, Xu R, Flanagan ME, Pieper AA, Qi X. Sci Adv. 2020 Dec 4;6(49). pii: 6/49/eabb8680. doi: 10.1126/sciadv.abb8680. Print 2020 Dec. PubMed |
| Growth of pancreatic cancers with hemizygous chromosomal 17p loss of MYBBP1A can be preferentially targeted by PARP inhibitors. Hsieh A, Pitarresi JR, Lerner J, Donahue G, Hsiehchen D, Rustgi AK, Zaret K. Sci Adv. 2020 Dec 4;6(49). pii: 6/49/eabc4517. doi: 10.1126/sciadv.abc4517. Print 2020 Dec. PubMed |
| Epigenetic activation of a RAS/MYC axis in H3.3K27M-driven cancer. Pajovic S, Siddaway R, Bridge T, Sheth J, Rakopoulos P, Kim B, Ryall S, Agnihotri S, Phillips L, Yu M, Li C, Milos S, Patel P, Srikanthan D, Huang A, Hawkins C. Nat Commun. 2020 Dec 4;11(1):6216. doi: 10.1038/s41467-020-19972-7. PubMed |
| Wnt16 signaling promotes osteoblast differentiation of periosteal derived cells in vitro and in vivo. Jin Y, Sun X, Pei F, Zhao Z, Mao J. PeerJ. 2020 Nov 24;8:e10374. doi: 10.7717/peerj.10374. eCollection 2020. PubMed |
| Sterol and oxysterol synthases near the ciliary base activate the Hedgehog pathway. Findakly S, Daggubati V, Garcia G, LaStella SA, Choudhury A, Tran C, Li A, Tong P, Garcia JQ, Puri N, Reiter JF, Xu L, Raleigh DR. J Cell Biol. 2021 Jan 4;220(1). pii: 211576. doi: 10.1083/jcb.202002026. PubMed |
Binding and transport of SFPQ-RNA granules by KIF5A/KLC1 motors promotes axon survival.
Fukuda Y, Pazyra-Murphy MF, Silagi ES, Tasdemir-Yilmaz OE, Li Y, Rose L, Yeoh ZC, Vangos NE, Geffken EA, Seo HS, Adelmant G, Bird GH, Walensky LD, Marto JA, Dhe-Paganon S, Segal RA.
J Cell Biol. 2021 Jan 4;220(1). pii: 211577. doi: 10.1083/jcb.202005051.
PubMed
Associated Plasmids |
| Measuring Circadian Rhythms in Human Cells. Du NH, Brown SA. Methods Mol Biol. 2021;2130:53-67. doi: 10.1007/978-1-0716-0381-9_4. PubMed |
| Searching Novel Clock Genes Using RNAi-Based Screening. Maier B, Lorenzen S, Finger AM, Herzel H, Kramer A. Methods Mol Biol. 2021;2130:103-114. doi: 10.1007/978-1-0716-0381-9_8. PubMed |
| Gene Regulatory Network Analysis and Engineering Directs Development and Vascularization of Multilineage Human Liver Organoids. Velazquez JJ, LeGraw R, Moghadam F, Tan Y, Kilbourne J, Maggiore JC, Hislop J, Liu S, Cats D, Chuva de Sousa Lopes SM, Plaisier C, Cahan P, Kiani S, Ebrahimkhani MR. Cell Syst. 2021 Jan 20;12(1):41-55.e11. doi: 10.1016/j.cels.2020.11.002. Epub 2020 Dec 7. PubMed |
| Intestinal region-specific Wnt signalling profiles reveal interrelation between cell identity and oncogenic pathway activity in cancer development. Adam RS, van Neerven SM, Pleguezuelos-Manzano C, Simmini S, Leveille N, de Groot NE, Holding AN, Markowetz F, Vermeulen L. Cancer Cell Int. 2020 Dec 3;20(1):578. doi: 10.1186/s12935-020-01661-6. PubMed |
| PD-L1 chimeric costimulatory receptor improves the efficacy of CAR-T cells for PD-L1-positive solid tumors and reduces toxicity in vivo. Liao Q, Mao Y, He H, Ding X, Zhang X, Xu J. Biomark Res. 2020 Nov 2;8(1):57. doi: 10.1186/s40364-020-00237-w. PubMed |
| Primary effusion lymphoma enhancer connectome links super-enhancers to dependency factors. Wang C, Zhang L, Ke L, Ding W, Jiang S, Li D, Narita Y, Hou I, Liang J, Li S, Xiao H, Gottwein E, Kaye KM, Teng M, Zhao B. Nat Commun. 2020 Dec 9;11(1):6318. doi: 10.1038/s41467-020-20136-w. PubMed |
Arterialization requires the timely suppression of cell growth.
Luo W, Garcia-Gonzalez I, Fernandez-Chacon M, Casquero-Garcia V, Sanchez-Munoz MS, Muhleder S, Garcia-Ortega L, Andrade J, Potente M, Benedito R.
Nature. 2021 Jan;589(7842):437-441. doi: 10.1038/s41586-020-3018-x. Epub 2020 Dec 9.
PubMed
Associated Plasmids |
| A Novel Nonsense GLI3 Variant Is Associated With Polydactyly and Syndactyly in a Family by Blocking the Sonic Hedgehog Signaling Pathway. Xiang Y, Li X, Zhan Z, Feng J, Cai H, Li Y, Fu Q, Xu Y, Jiang H, Zhang X. Front Genet. 2020 Nov 10;11:542004. doi: 10.3389/fgene.2020.542004. eCollection 2020. PubMed |
| Inhibition of Wnt signaling by Frizzled7 antibody-coated nanoshells sensitizes triple-negative breast cancer cells to the autophagy regulator chloroquine. Wang J, Dang MN, Day ES. Nano Res. 2020 Jun;13(6):1693-1703. doi: 10.1007/s12274-020-2795-8. Epub 2020 Apr 25. PubMed |
| The long non-coding RNA LUCAT1 is a negative feedback regulator of interferon responses in humans. Agarwal S, Vierbuchen T, Ghosh S, Chan J, Jiang Z, Kandasamy RK, Ricci E, Fitzgerald KA. Nat Commun. 2020 Dec 11;11(1):6348. doi: 10.1038/s41467-020-20165-5. PubMed |
| Satellite cell expansion is mediated by P-eIF2alpha-dependent Tacc3 translation. Fujita R, Jamet S, Lean G, Cheng HCM, Hebert S, Kleinman CL, Crist C. Development. 2021 Jan 20;148(2). pii: dev.194480. doi: 10.1242/dev.194480. PubMed |
Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q.
Neggers JE, Paolella BR, Asfaw A, Rothberg MV, Skipper TA, Yang A, Kalekar RL, Krill-Burger JM, Dharia NV, Kugener G, Kalfon J, Yuan C, Dumont N, Gonzalez A, Abdusamad M, Li YY, Spurr LF, Wu WW, Durbin AD, Wolpin BM, Piccioni F, Root DE, Boehm JS, Cherniack AD, Tsherniak A, Hong AL, Hahn WC, Stegmaier K, Golub TR, Vazquez F, Aguirre AJ.
Cell Rep. 2020 Dec 15;33(11):108493. doi: 10.1016/j.celrep.2020.108493.
PubMed
Associated Plasmids |
| An activity-dependent local transport regulation via degradation and synthesis of KIF17 underlying cognitive flexibility. Iwata S, Morikawa M, Takei Y, Hirokawa N. Sci Adv. 2020 Dec 16;6(51). pii: 6/51/eabc8355. doi: 10.1126/sciadv.abc8355. Print 2020 Dec. PubMed |
| Functional skeletal muscle constructs from transdifferentiated human fibroblasts. Xu B, Siehr A, Shen W. Sci Rep. 2020 Dec 16;10(1):22047. doi: 10.1038/s41598-020-78987-8. PubMed |
| USP13 interacts with cohesin and regulates its ubiquitination in human cells. He X, Kim JS, Diaz-Martinez LA, Han C, Lane WS, Budnik B, Waldman T. J Biol Chem. 2021 Jan-Jun;296:100194. doi: 10.1074/jbc.RA120.015762. Epub 2020 Dec 20. PubMed |
| Enhancing cardiac reprogramming via synthetic RNA oligonucleotides. Hu J, Hodgkinson CP, Pratt RE, Lee J, Sullenger BA, Dzau VJ. Mol Ther Nucleic Acids. 2020 Oct 27;23:55-62. doi: 10.1016/j.omtn.2020.10.034. eCollection 2021 Mar 5. PubMed |
| The TOP vector: a new high-titer lentiviral construct for delivery of sgRNAs and transgenes to primary T cells. Humes D, Rainwater S, Overbaugh J. Mol Ther Methods Clin Dev. 2020 Oct 27;20:30-38. doi: 10.1016/j.omtm.2020.10.020. eCollection 2021 Mar 12. PubMed |
| TMEM41B Is a Pan-flavivirus Host Factor. Hoffmann HH, Schneider WM, Rozen-Gagnon K, Miles LA, Schuster F, Razooky B, Jacobson E, Wu X, Yi S, Rudin CM, MacDonald MR, McMullan LK, Poirier JT, Rice CM. Cell. 2021 Jan 7;184(1):133-148.e20. doi: 10.1016/j.cell.2020.12.005. Epub 2020 Dec 9. PubMed |
| Centriolar distal appendages activate the centrosome-PIDDosome-p53 signalling axis via ANKRD26. Burigotto M, Mattivi A, Migliorati D, Magnani G, Valentini C, Roccuzzo M, Offterdinger M, Pizzato M, Schmidt A, Villunger A, Maffini S, Fava LL. EMBO J. 2021 Feb 15;40(4):e104844. doi: 10.15252/embj.2020104844. Epub 2020 Dec 22. PubMed |
| ANKRD26 recruits PIDD1 to centriolar distal appendages to activate the PIDDosome following centrosome amplification. Evans LT, Anglen T, Scott P, Lukasik K, Loncarek J, Holland AJ. EMBO J. 2021 Feb 15;40(4):e105106. doi: 10.15252/embj.2020105106. Epub 2020 Dec 22. PubMed |
| Altered glycosylation of IgG4 promotes lectin complement pathway activation in anti-PLA2R1-associated membranous nephropathy. Haddad G, Lorenzen JM, Ma H, de Haan N, Seeger H, Zaghrini C, Brandt S, Kolling M, Wegmann U, Kiss B, Pal G, Gal P, Wuthrich RP, Wuhrer M, Beck LH, Salant DJ, Lambeau G, Kistler AD. J Clin Invest. 2021 Mar 1;131(5). pii: 140453. doi: 10.1172/JCI140453. PubMed |
| High affinity nanobodies block SARS-CoV-2 spike receptor binding domain interaction with human angiotensin converting enzyme. Esparza TJ, Martin NP, Anderson GP, Goldman ER, Brody DL. Sci Rep. 2020 Dec 22;10(1):22370. doi: 10.1038/s41598-020-79036-0. PubMed |
| Clustering of desmosomal cadherins by desmoplakin is essential for cell-cell adhesion. Wanuske MT, Brantschen D, Schinner C, Studle C, Walter E, Hiermaier M, Vielmuth F, Waschke J, Spindler V. Acta Physiol (Oxf). 2021 Apr;231(4):e13609. doi: 10.1111/apha.13609. Epub 2021 Jan 19. PubMed |
| Manipulation of the human tRNA pool reveals distinct tRNA sets that act in cellular proliferation or cell cycle arrest. Aharon-Hefetz N, Frumkin I, Mayshar Y, Dahan O, Pilpel Y, Rak R. Elife. 2020 Dec 24;9. pii: 58461. doi: 10.7554/eLife.58461. PubMed |
| Massively parallel functional testing of MSH2 missense variants conferring Lynch syndrome risk. Jia X, Burugula BB, Chen V, Lemons RM, Jayakody S, Maksutova M, Kitzman JO. Am J Hum Genet. 2021 Jan 7;108(1):163-175. doi: 10.1016/j.ajhg.2020.12.003. Epub 2020 Dec 23. PubMed |
| Immunogenic Chemotherapy Enhances Recruitment of CAR-T Cells to Lung Tumors and Improves Antitumor Efficacy when Combined with Checkpoint Blockade. Srivastava S, Furlan SN, Jaeger-Ruckstuhl CA, Sarvothama M, Berger C, Smythe KS, Garrison SM, Specht JM, Lee SM, Amezquita RA, Voillet V, Muhunthan V, Yechan-Gunja S, Pillai SPS, Rader C, Houghton AM, Pierce RH, Gottardo R, Maloney DG, Riddell SR. Cancer Cell. 2021 Feb 8;39(2):193-208.e10. doi: 10.1016/j.ccell.2020.11.005. Epub 2020 Dec 24. PubMed |
| Discovery of cellular substrates of human RNA-decapping enzyme DCP2 using a stapled bicyclic peptide inhibitor. Luo Y, Schofield JA, Na Z, Hann T, Simon MD, Slavoff SA. Cell Chem Biol. 2021 Apr 15;28(4):463-474.e7. doi: 10.1016/j.chembiol.2020.12.003. Epub 2020 Dec 22. PubMed |
| ZG16 regulates PD-L1 expression and promotes local immunity in colon cancer. Meng H, Ding Y, Liu E, Li W, Wang L. Transl Oncol. 2021 Feb;14(2):101003. doi: 10.1016/j.tranon.2020.101003. Epub 2020 Dec 25. PubMed |
| A CRISPR-Cas13a Based Strategy That Tracks and Degrades Toxic RNA in Myotonic Dystrophy Type 1. Zhang N, Bewick B, Xia G, Furling D, Ashizawa T. Front Genet. 2020 Dec 10;11:594576. doi: 10.3389/fgene.2020.594576. eCollection 2020. PubMed |
| Lentiviral vector with a radiation-inducible promoter, carrying the ING4 gene, mediates radiosensitization controlled by radiotherapy in cervical cancer cells. Ma T, Guo R, Wang X, Shen WT, Zhu M, Jin YN, Xu HP. Oncol Lett. 2021 Jan;21(1):67. doi: 10.3892/ol.2020.12328. Epub 2020 Nov 25. PubMed |
| USP22 controls necroptosis by regulating receptor-interacting protein kinase 3 ubiquitination. Roedig J, Kowald L, Juretschke T, Karlowitz R, Ahangarian Abhari B, Roedig H, Fulda S, Beli P, van Wijk SJ. EMBO Rep. 2021 Feb 3;22(2):e50163. doi: 10.15252/embr.202050163. Epub 2020 Dec 28. PubMed |
| Differential Regulation of Cancer Progression by CDK4/6 Plays a Central Role in DNA Replication and Repair Pathways. Dai M, Boudreault J, Wang N, Poulet S, Daliah G, Yan G, Moamer A, Burgos SA, Sabri S, Ali S, Lebrun JJ. Cancer Res. 2021 Mar 1;81(5):1332-1346. doi: 10.1158/0008-5472.CAN-20-2121. Epub 2020 Dec 28. PubMed |
| UFMylation inhibits the proinflammatory capacity of interferon-gamma-activated macrophages. Balce DR, Wang YT, McAllaster MR, Dunlap BF, Orvedahl A, Hykes BL Jr, Droit L, Handley SA, Wilen CB, Doench JG, Orchard RC, Stallings CL, Virgin HW. Proc Natl Acad Sci U S A. 2021 Jan 5;118(1). pii: 2011763118. doi: 10.1073/pnas.2011763118. PubMed |
| Genome-wide CRISPR screen identifies regulators of MAPK and MTOR pathways mediating sorafenib resistance in acute myeloid leukemia. Damnernsawad A, Bottomly D, Kurtz SE, Eide CA, McWeeney SK, Tyner JW, Nechiporuk T. Haematologica. 2020 Dec 30;Online ahead of print. doi: 10.3324/haematol.2020.257964. PubMed |
| An Improved Protocol for the Production of Lentiviral Vectors. Brown LY, Dong W, Kantor B. STAR Protoc. 2020 Oct 27;1(3):100152. doi: 10.1016/j.xpro.2020.100152. eCollection 2020 Dec 18. PubMed |
| P2X-GCaMPs as Versatile Tools for Imaging Extracellular ATP Signaling. Ollivier M, Beudez J, Linck N, Grutter T, Compan V, Rassendren F. eNeuro. 2021 Jan 28;8(1). pii: ENEURO.0185-20.2020. doi: 10.1523/ENEURO.0185-20.2020. Print 2021 Jan-Feb. PubMed |
| LncRNA FTX Promotes Colorectal Cancer Cells Migration and Invasion by miRNA-590-5p/RBPJ Axis. Chen GQ, Liao ZM, Liu J, Li F, Huang D, Zhou YD. Biochem Genet. 2021 Apr;59(2):560-573. doi: 10.1007/s10528-020-10017-8. Epub 2021 Jan 3. PubMed |
| Transcriptional regulation of VEGFA expression in T-regulatory cells from breast cancer patients. Kajal K, Bose S, Panda AK, Chakraborty D, Chakraborty S, Pati S, Sarkar T, Dhar S, Roy D, Saha S, Sa G. Cancer Immunol Immunother. 2021 Jul;70(7):1877-1891. doi: 10.1007/s00262-020-02808-0. Epub 2021 Jan 4. PubMed |
| ZBP1 promotes LPS-induced cell death and IL-1beta release via RHIM-mediated interactions with RIPK1. Muendlein HI, Connolly WM, Magri Z, Smirnova I, Ilyukha V, Gautam A, Degterev A, Poltorak A. Nat Commun. 2021 Jan 4;12(1):86. doi: 10.1038/s41467-020-20357-z. PubMed |
| Functional Genomics Identify Distinct and Overlapping Genes Mediating Resistance to Different Classes of Heterobifunctional Degraders of Oncoproteins. Shirasaki R, Matthews GM, Gandolfi S, de Matos Simoes R, Buckley DL, Raja Vora J, Sievers QL, Bruggenthies JB, Dashevsky O, Poarch H, Tang H, Bariteau MA, Sheffer M, Hu Y, Downey-Kopyscinski SL, Hengeveld PJ, Glassner BJ, Dhimolea E, Ott CJ, Zhang T, Kwiatkowski NP, Laubach JP, Schlossman RL, Richardson PG, Culhane AC, Groen RWJ, Fischer ES, Vazquez F, Tsherniak A, Hahn WC, Levy J, Auclair D, Licht JD, Keats JJ, Boise LH, Ebert BL, Bradner JE, Gray NS, Mitsiades CS. Cell Rep. 2021 Jan 5;34(1):108532. doi: 10.1016/j.celrep.2020.108532. PubMed |
| Metastatic colorectal cancer cells maintain the TGFbeta program and use TGFBI to fuel angiogenesis. Chiavarina B, Costanza B, Ronca R, Blomme A, Rezzola S, Chiodelli P, Giguelay A, Belthier G, Doumont G, Van Simaeys G, Lacroix S, Yokobori T, Erkhem-Ochir B, Balaguer P, Cavailles V, Fabbrizio E, Di Valentin E, Gofflot S, Detry O, Jerusalem G, Goldman S, Delvenne P, Bellahcene A, Pannequin J, Castronovo V, Turtoi A. Theranostics. 2021 Jan 1;11(4):1626-1640. doi: 10.7150/thno.51507. eCollection 2021. PubMed |
| Mechanism and restoration strategy of lysosomal abnormalities induced by urinary protein overload in proximal tubule epithelial cells. Li X, Zou T, Wang S, Wu H, Wu M, Liu Z, Liu H. Dev Dyn. 2021 Jan 6. doi: 10.1002/dvdy.297. PubMed |
| Diverse viral proteases activate the NLRP1 inflammasome. Tsu BV, Beierschmitt C, Ryan AP, Agarwal R, Mitchell PS, Daugherty MD. Elife. 2021 Jan 7;10. pii: 60609. doi: 10.7554/eLife.60609. PubMed |
| The serine-48 residue of nucleolar phosphoprotein nucleophosmin-1 plays critical role in subcellular localization and interaction with porcine circovirus type 3 capsid protein. Zhou J, Li J, Li H, Zhang Y, Dong W, Jin Y, Yan Y, Gu J, Zhou J. Vet Res. 2021 Jan 7;52(1):4. doi: 10.1186/s13567-020-00876-9. PubMed |
| Ferroptosis induces membrane blebbing in placental trophoblasts. Kajiwara K, Beharier O, Chng CP, Goff JP, Ouyang Y, St Croix CM, Huang C, Kagan VE, Hsia KJ, Sadovsky Y. J Cell Sci. 2022 Mar 1;135(5). pii: jcs.255737. doi: 10.1242/jcs.255737. Epub 2021 Apr 20. PubMed |
| Inhibition of caspase-3-mediated GSDME-derived pyroptosis aids in noncancerous tissue protection of squamous cell carcinoma patients during cisplatin-based chemotherapy. Huang Z, Zhang Q, Wang Y, Chen R, Wang Y, Huang Z, Zhou G, Li H, Rui X, Jin T, Li S, Zhang Y, Huang Z. Am J Cancer Res. 2020 Dec 1;10(12):4287-4307. eCollection 2020. PubMed |
| Directly Reprogrammed Neurons Express MAPT and APP Splice Variants Pertinent to Ageing and Neurodegeneration. Habekost M, Qvist P, Denham M, Holm IE, Jorgensen AL. Mol Neurobiol. 2021 May;58(5):2075-2087. doi: 10.1007/s12035-020-02258-w. Epub 2021 Jan 7. PubMed |
| Interaction between SNAI2 and MYOD enhances oncogenesis and suppresses differentiation in Fusion Negative Rhabdomyosarcoma. Pomella S, Sreenivas P, Gryder BE, Wang L, Milewski D, Cassandri M, Baxi K, Hensch NR, Carcarino E, Song Y, Chou HC, Yohe ME, Stanton BZ, Amadio B, Caruana I, De Stefanis C, De Vito R, Locatelli F, Chen Y, Chen EY, Houghton P, Khan J, Rota R, Ignatius MS. Nat Commun. 2021 Jan 8;12(1):192. doi: 10.1038/s41467-020-20386-8. PubMed |
| SLE non-coding genetic risk variant determines the epigenetic dysfunction of an immune cell specific enhancer that controls disease-critical microRNA expression. Hou G, Harley ITW, Lu X, Zhou T, Xu N, Yao C, Qin Y, Ouyang Y, Ma J, Zhu X, Yu X, Xu H, Dai D, Ding H, Yin Z, Ye Z, Deng J, Zhou M, Tang Y, Namjou B, Guo Y, Weirauch MT, Kottyan LC, Harley JB, Shen N. Nat Commun. 2021 Jan 8;12(1):135. doi: 10.1038/s41467-020-20460-1. PubMed |
| PRMT1 enhances oncogenic arginine methylation of NONO in colorectal cancer. Yin XK, Wang YL, Wang F, Feng WX, Bai SM, Zhao WW, Feng LL, Wei MB, Qin CL, Wang F, Chen ZL, Yi HJ, Huang Y, Xie PY, Kim T, Wang YN, Hou JW, Li CW, Liu Q, Fan XJ, Hung MC, Wan XB. Oncogene. 2021 Feb;40(7):1375-1389. doi: 10.1038/s41388-020-01617-0. Epub 2021 Jan 8. PubMed |
| The TGF-beta superfamily cytokine Activin-A is induced during autoimmune neuroinflammation and drives pathogenic Th17 cell differentiation. Wu B, Zhang S, Guo Z, Bi Y, Zhou M, Li P, Seyedsadr M, Xu X, Li JL, Markovic-Plese S, Wan YY. Immunity. 2021 Feb 9;54(2):308-323.e6. doi: 10.1016/j.immuni.2020.12.010. Epub 2021 Jan 8. PubMed |
| Temperature is a key determinant of alpha- and beta-synuclein membrane interactions in neurons. Ramalingam N, Dettmer U. J Biol Chem. 2021 Jan-Jun;296:100271. doi: 10.1016/j.jbc.2021.100271. Epub 2021 Jan 9. PubMed |
| Ectopic Expression of Genotype 1 Hepatitis E Virus ORF4 Increases Genotype 3 HEV Viral Replication in Cell Culture. Yadav KK, Boley PA, Fritts Z, Kenney SP. Viruses. 2021 Jan 7;13(1). pii: v13010075. doi: 10.3390/v13010075. PubMed |
| Isolation of MERS-related coronavirus from lesser bamboo bats that uses DPP4 and infects human-DPP4-transgenic mice. Lau SKP, Fan RYY, Zhu L, Li KSM, Wong ACP, Luk HKH, Wong EYM, Lam CSF, Lo GCS, Fung J, He Z, Fok FCH, Au-Yeung RKH, Zhang L, Kok KH, Yuen KY, Woo PCY. Nat Commun. 2021 Jan 11;12(1):216. doi: 10.1038/s41467-020-20458-9. PubMed |
| Direct Intracellular Visualization of Ebola Virus-Receptor Interaction by In Situ Proximity Ligation. Mittler E, Alkutkar T, Jangra RK, Chandran K. mBio. 2021 Jan 12;12(1). pii: mBio.03100-20. doi: 10.1128/mBio.03100-20. PubMed |
| Differential effects on human cytochromes P450 by CRISPR/Cas9-induced genetic knockout of cytochrome P450 reductase and cytochrome b5 in HepaRG cells. Heintze T, Klein K, Hofmann U, Zanger UM. Sci Rep. 2021 Jan 13;11(1):1000. doi: 10.1038/s41598-020-79952-1. PubMed |
| Loss of Mediator complex subunit 13 (MED13) promotes resistance to alkylation through cyclin D1 upregulation. Rolinski M, Montaldo NP, Aksu ME, Fordyce Martin SL, Brambilla A, Kunath N, Johansen J, Erlandsen SE, Liabbak NB, Rian K, Bjoras M, Saetrom P, van Loon B. Nucleic Acids Res. 2021 Feb 22;49(3):1470-1484. doi: 10.1093/nar/gkaa1289. PubMed |
| SIX2 and SIX3 coordinately regulate functional maturity and fate of human pancreatic beta cells. Bevacqua RJ, Lam JY, Peiris H, Whitener RL, Kim S, Gu X, Friedlander MSH, Kim SK. Genes Dev. 2021 Feb 1;35(3-4):234-249. doi: 10.1101/gad.342378.120. Epub 2021 Jan 14. PubMed |
| Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy. Tajan M, Hennequart M, Cheung EC, Zani F, Hock AK, Legrave N, Maddocks ODK, Ridgway RA, Athineos D, Suarez-Bonnet A, Ludwig RL, Novellasdemunt L, Angelis N, Li VSW, Vlachogiannis G, Valeri N, Mainolfi N, Suri V, Friedman A, Manfredi M, Blyth K, Sansom OJ, Vousden KH. Nat Commun. 2021 Jan 14;12(1):366. doi: 10.1038/s41467-020-20223-y. PubMed |
| HAND1 and BARX1 Act as Transcriptional and Anatomic Determinants of Malignancy in Gastrointestinal Stromal Tumor. Hemming ML, Coy S, Lin JR, Andersen JL, Przybyl J, Mazzola E, Abdelhamid Ahmed AH, van de Rijn M, Sorger PK, Armstrong SA, Demetri GD, Santagata S. Clin Cancer Res. 2021 Mar 15;27(6):1706-1719. doi: 10.1158/1078-0432.CCR-20-3538. Epub 2021 Jan 15. PubMed |
| A CRISPR/Cas9-Engineered ARID1A-Deficient Human Gastric Cancer Organoid Model Reveals Essential and Nonessential Modes of Oncogenic Transformation. Lo YH, Kolahi KS, Du Y, Chang CY, Krokhotin A, Nair A, Sobba WD, Karlsson K, Jones SJ, Longacre TA, Mah AT, Tercan B, Sockell A, Xu H, Seoane JA, Chen J, Shmulevich I, Weissman JS, Curtis C, Califano A, Fu H, Crabtree GR, Kuo CJ. Cancer Discov. 2021 Jun;11(6):1562-1581. doi: 10.1158/2159-8290.CD-20-1109. Epub 2021 Jan 15. PubMed |
| EBF1 drives hallmark B cell gene expression by enabling the interaction of PAX5 with the MLL H3K4 methyltransferase complex. Bullerwell CE, Robichaud PP, Deprez PML, Joy AP, Wajnberg G, D'Souza D, Chacko S, Fournier S, Crapoulet N, Barnett DA, Lewis SM, Ouellette RJ. Sci Rep. 2021 Jan 15;11(1):1537. doi: 10.1038/s41598-021-81000-5. PubMed |
| m(6) A deposition is regulated by PRMT1-mediated arginine methylation of METTL14 in its disordered C-terminal region. Wang Z, Pan Z, Adhikari S, Harada BT, Shen L, Yuan W, Abeywardana T, Al-Hadid Q, Stark JM, He C, Lin L, Yang Y. EMBO J. 2021 Mar 1;40(5):e106309. doi: 10.15252/embj.2020106309. Epub 2021 Jan 18. PubMed |
| Autophagy activation, lipotoxicity and lysosomal membrane permeabilization synergize to promote pimozide- and loperamide-induced glioma cell death. Meyer N, Henkel L, Linder B, Zielke S, Tascher G, Trautmann S, Geisslinger G, Munch C, Fulda S, Tegeder I, Kogel D. Autophagy. 2021 Nov;17(11):3424-3443. doi: 10.1080/15548627.2021.1874208. Epub 2021 Jan 19. PubMed |
| Deletion of Cbl-b inhibits CD8(+) T-cell exhaustion and promotes CAR T-cell function. Kumar J, Kumar R, Kumar Singh A, Tsakem EL, Kathania M, Riese MJ, Theiss AL, Davila ML, Venuprasad K. J Immunother Cancer. 2021 Jan;9(1). pii: jitc-2020-001688. doi: 10.1136/jitc-2020-001688. PubMed |
| Tetracyclines promote survival and fitness in mitochondrial disease models. Perry EA, Bennett CF, Luo C, Balsa E, Jedrychowski M, O'Malley KE, Latorre-Muro P, Ladley RP, Reda K, Wright PM, Gygi SP, Myers AG, Puigserver P. Nat Metab. 2021 Jan;3(1):33-42. doi: 10.1038/s42255-020-00334-y. Epub 2021 Jan 18. PubMed |
CRNKL1 Is a Highly Selective Regulator of Intron-Retaining HIV-1 and Cellular mRNAs.
Xiao H, Wyler E, Milek M, Grewe B, Kirchner P, Ekici A, Silva ABOV, Jungnickl D, Full F, Thomas M, Landthaler M, Ensser A, Uberla K.
mBio. 2021 Jan 19;12(1). pii: mBio.02525-20. doi: 10.1128/mBio.02525-20.
PubMed
Associated Plasmids |
| A DYRK1B-dependent pathway suppresses rDNA transcription in response to DNA damage. Dong C, An L, Yu CH, Huen MSY. Nucleic Acids Res. 2021 Feb 22;49(3):1485-1496. doi: 10.1093/nar/gkaa1290. PubMed |
| The mitochondrial protein ERAL1 suppresses RNA virus infection by facilitating RIG-I-like receptor signaling. Li S, Kuang M, Chen L, Li Y, Liu S, Du H, Cao L, You F. Cell Rep. 2021 Jan 19;34(3):108631. doi: 10.1016/j.celrep.2020.108631. PubMed |
| Therapeutic development of group B Streptococcus meningitis by targeting a host cell signaling network involving EGFR. Zhu N, Zhang C, Prakash A, Hou Z, Liu W, She W, Morris A, Sik Kim K. EMBO Mol Med. 2021 Mar 5;13(3):e12651. doi: 10.15252/emmm.202012651. Epub 2021 Jan 21. PubMed |
| IFNbeta1 secreted by breast cancer cells undergoing chemotherapy reprograms stromal fibroblasts to support tumour growth after treatment. Maia A, Gu Z, Koch A, Berdiel-Acer M, Will R, Schlesner M, Wiemann S. Mol Oncol. 2021 May;15(5):1308-1329. doi: 10.1002/1878-0261.12905. Epub 2021 Feb 11. PubMed |
ER-directed TREX1 limits cGAS activation at micronuclei.
Mohr L, Toufektchan E, von Morgen P, Chu K, Kapoor A, Maciejowski J.
Mol Cell. 2021 Jan 12. pii: S1097-2765(20)30958-8. doi: 10.1016/j.molcel.2020.12.037.
PubMed
Associated Plasmids |
| T cell receptor-dependent S-acylation of ZAP-70 controls activation of T cells. Tewari R, Shayahati B, Fan Y, Akimzhanov AM. J Biol Chem. 2021 Jan-Jun;296:100311. doi: 10.1016/j.jbc.2021.100311. Epub 2021 Jan 19. PubMed |
| BMI1 enables extensive expansion of functional erythroblasts from human peripheral blood mononuclear cells. Liu S, Wu M, Lancelot M, Deng J, Gao Y, Roback JD, Chen T, Cheng L. Mol Ther. 2021 May 5;29(5):1918-1932. doi: 10.1016/j.ymthe.2021.01.022. Epub 2021 Jan 21. PubMed |
| Loss of G-Protein Pathway Suppressor 2 Promotes Tumor Growth Through Activation of AKT Signaling. Chan S, Smith E, Gao Y, Kwan J, Blum BC, Tilston-Lunel AM, Turcinovic I, Varelas X, Cardamone MD, Monti S, Emili A, Perissi V. Front Cell Dev Biol. 2021 Jan 7;8:608044. doi: 10.3389/fcell.2020.608044. eCollection 2020. PubMed |
| Evasion of Innate Immunity Contributes to Small Cell Lung Cancer Progression and Metastasis. Zhu M, Huang Y, Bender ME, Girard L, Kollipara R, Eglenen-Polat B, Naito Y, Savage TK, Huffman KE, Koyama S, Kumanogoh A, Minna JD, Johnson JE, Akbay EA. Cancer Res. 2021 Apr 1;81(7):1813-1826. doi: 10.1158/0008-5472.CAN-20-2808. Epub 2021 Jan 25. PubMed |
| SFPQ regulates the accumulation of RNA foci and dipeptide repeat proteins from the expanded repeat mutation in C9orf72. Malnar M, Rogelj B. J Cell Sci. 2021 Feb 19;134(4). pii: jcs.256602. doi: 10.1242/jcs.256602. PubMed |
| DHODH inhibition synergizes with DNA-demethylating agents in the treatment of myelodysplastic syndromes. Kayamori K, Nagai Y, Zhong C, Kaito S, Shinoda D, Koide S, Kuribayashi W, Oshima M, Nakajima-Takagi Y, Yamashita M, Mimura N, Becker HJ, Izawa K, Yamazaki S, Iwano S, Miyawaki A, Ito R, Tohyama K, Lennox W, Sheedy J, Weetall M, Sakaida E, Yokote K, Iwama A. Blood Adv. 2021 Jan 26;5(2):438-450. doi: 10.1182/bloodadvances.2020001461. PubMed |
| G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling. Prentzell MT, Rehbein U, Cadena Sandoval M, De Meulemeester AS, Baumeister R, Brohee L, Berdel B, Bockwoldt M, Carroll B, Chowdhury SR, von Deimling A, Demetriades C, Figlia G, de Araujo MEG, Heberle AM, Heiland I, Holzwarth B, Huber LA, Jaworski J, Kedra M, Kern K, Kopach A, Korolchuk VI, van 't Land-Kuper I, Macias M, Nellist M, Palm W, Pusch S, Ramos Pittol JM, Reil M, Reintjes A, Reuter F, Sampson JR, Scheldeman C, Siekierska A, Stefan E, Teleman AA, Thomas LE, Torres-Quesada O, Trump S, West HD, de Witte P, Woltering S, Yordanov TE, Zmorzynska J, Opitz CA, Thedieck K. Cell. 2021 Feb 4;184(3):655-674.e27. doi: 10.1016/j.cell.2020.12.024. Epub 2021 Jan 25. PubMed |
| Functional Hierarchy and Cooperation of EMT Master Transcription Factors in Breast Cancer Metastasis. Addison JB, Voronkova MA, Fugett JH, Lin CC, Linville NC, Trinh B, Livengood RH, Smolkin MB, Schaller MD, Ruppert JM, Pugacheva EN, Creighton CJ, Ivanov AV. Mol Cancer Res. 2021 May;19(5):784-798. doi: 10.1158/1541-7786.MCR-20-0532. Epub 2021 Jan 26. PubMed |
| The Novel ALG-2 Target Protein CDIP1 Promotes Cell Death by Interacting with ESCRT-I and VAPA/B. Inukai R, Mori K, Kuwata K, Suzuki C, Maki M, Takahara T, Shibata H. Int J Mol Sci. 2021 Jan 25;22(3). pii: ijms22031175. doi: 10.3390/ijms22031175. PubMed |
| IDH1 mutations induce organelle defects via dysregulated phospholipids. Lita A, Pliss A, Kuzmin A, Yamasaki T, Zhang L, Dowdy T, Burks C, de Val N, Celiku O, Ruiz-Rodado V, Nicoli ER, Kruhlak M, Andresson T, Das S, Yang C, Schmitt R, Herold-Mende C, Gilbert MR, Prasad PN, Larion M. Nat Commun. 2021 Jan 27;12(1):614. doi: 10.1038/s41467-020-20752-6. PubMed |
| TALEN outperforms Cas9 in editing heterochromatin target sites. Jain S, Shukla S, Yang C, Zhang M, Fatma Z, Lingamaneni M, Abesteh S, Lane ST, Xiong X, Wang Y, Schroeder CM, Selvin PR, Zhao H. Nat Commun. 2021 Jan 27;12(1):606. doi: 10.1038/s41467-020-20672-5. PubMed |
| Depletion of Survivin suppresses docetaxel-induced apoptosis in HeLa cells by facilitating mitotic slippage. Han TL, Sha H, Ji J, Li YT, Wu DS, Lin H, Hu B, Jiang ZX. Sci Rep. 2021 Jan 27;11(1):2283. doi: 10.1038/s41598-021-81563-3. PubMed |
| Support of BCP-ALL-cells by autologous bone marrow Th-cells involves induction of AID expression but not widespread AID off-target mutagenesis. Traxel S, Lehmann J, Richard S, Sidorov S, Niggli F, Berger C, Nadal D, Burgler S. Cancer Immunol Immunother. 2021 Jan 28. pii: 10.1007/s00262-020-02835-x. doi: 10.1007/s00262-020-02835-x. PubMed |
| A host receptor enables type 1 pilus-mediated pathogenesis of Escherichia coli pyelonephritis. McLellan LK, McAllaster MR, Kim AS, Tothova L, Olson PD, Pinkner JS, Daugherty AL, Hreha TN, Janetka JW, Fremont DH, Hultgren SJ, Virgin HW, Hunstad DA. PLoS Pathog. 2021 Jan 29;17(1):e1009314. doi: 10.1371/journal.ppat.1009314. eCollection 2021 Jan. PubMed |
| Prototypical oncogene family Myc defines unappreciated distinct lineage states of small cell lung cancer. Patel AS, Yoo S, Kong R, Sato T, Sinha A, Karam S, Bao L, Fridrikh M, Emoto K, Nudelman G, Powell CA, Beasley MB, Zhu J, Watanabe H. Sci Adv. 2021 Jan 29;7(5). pii: 7/5/eabc2578. doi: 10.1126/sciadv.abc2578. Print 2021 Jan. PubMed |
Plexin-B2 facilitates glioblastoma infiltration by modulating cell biomechanics.
Huang Y, Tejero R, Lee VK, Brusco C, Hannah T, Bertucci TB, Junqueira Alves C, Katsyv I, Kluge M, Foty R, Zhang B, Friedel CC, Dai G, Zou H, Friedel RH.
Commun Biol. 2021 Jan 29;4(1):145. doi: 10.1038/s42003-021-01667-4.
PubMed
Associated Plasmids |
| LncRNA H19 Suppresses Osteosarcomagenesis by Regulating snoRNAs and DNA Repair Protein Complexes. Xu A, Huang MF, Zhu D, Gingold JA, Bazer DA, Chang B, Wang D, Lai CC, Lemischka IR, Zhao R, Lee DF. Front Genet. 2021 Jan 15;11:611823. doi: 10.3389/fgene.2020.611823. eCollection 2020. PubMed |
| Generation of SARS-CoV-2 Spike Pseudotyped Virus for Viral Entry and Neutralization Assays: A 1-Week Protocol. Condor Capcha JM, Lambert G, Dykxhoorn DM, Salerno AG, Hare JM, Whitt MA, Pahwa S, Jayaweera DT, Shehadeh LA. Front Cardiovasc Med. 2021 Jan 15;7:618651. doi: 10.3389/fcvm.2020.618651. eCollection 2020. PubMed |
| SATB2 induction of a neural crest mesenchyme-like program drives melanoma invasion and drug resistance. Fazio M, van Rooijen E, Dang M, van de Hoek G, Ablain J, Mito JK, Yang S, Thomas A, Michael J, Fabo T, Modhurima R, Pessina P, Kaufman CK, Zhou Y, White RM, Zon LI. Elife. 2021 Feb 2;10. pii: 64370. doi: 10.7554/eLife.64370. PubMed |
| RNF168 regulates R-loop resolution and genomic stability in BRCA1/2-deficient tumors. Patel PS, Abraham KJ, Guturi KKN, Halaby MJ, Khan Z, Palomero L, Ho B, Duan S, St-Germain J, Algouneh A, Mateo F, El Ghamrasni S, Barbour H, Barnes DR, Beesley J, Sanchez O, Berman HK, Brown GW, Affar EB, Chenevix-Trench G, Antoniou AC, Arrowsmith CH, Raught B, Pujana MA, Mekhail K, Hakem A, Hakem R. J Clin Invest. 2021 Feb 1;131(3). pii: 140105. doi: 10.1172/JCI140105. PubMed |
| ATF3 downmodulates its new targets IFI6 and IFI27 to suppress the growth and migration of tongue squamous cell carcinoma cells. Xu L, Zu T, Li T, Li M, Mi J, Bai F, Liu G, Wen J, Li H, Brakebusch C, Wang X, Wu X. PLoS Genet. 2021 Feb 4;17(2):e1009283. doi: 10.1371/journal.pgen.1009283. eCollection 2021 Feb. PubMed |
| PRMT6 methylation of RCC1 regulates mitosis, tumorigenicity, and radiation response of glioblastoma stem cells. Huang T, Yang Y, Song X, Wan X, Wu B, Sastry N, Horbinski CM, Zeng C, Tiek D, Goenka A, Liu F, Brennan CW, Kessler JA, Stupp R, Nakano I, Sulman EP, Nishikawa R, James CD, Zhang W, Xu W, Hu B, Cheng SY. Mol Cell. 2021 Mar 18;81(6):1276-1291.e9. doi: 10.1016/j.molcel.2021.01.015. Epub 2021 Feb 3. PubMed |
| A comprehensive phenotypic CRISPR-Cas9 screen of the ubiquitin pathway uncovers roles of ubiquitin ligases in mitosis. Hundley FV, Sanvisens Delgado N, Marin HC, Carr KL, Tian R, Toczyski DP. Mol Cell. 2021 Mar 18;81(6):1319-1336.e9. doi: 10.1016/j.molcel.2021.01.014. Epub 2021 Feb 3. PubMed |
| PTEN is required for the migration and invasion of Ras-transformed MDCK cells. Yan L, Tsujita K, Fujita Y, Itoh T. FEBS Lett. 2021 May;595(9):1303-1312. doi: 10.1002/1873-3468.14053. Epub 2021 Feb 20. PubMed |
| Distinct roles for the RNA-binding protein Staufen1 in prostate cancer. Marcellus KA, Crawford Parks TE, Almasi S, Jasmin BJ. BMC Cancer. 2021 Feb 4;21(1):120. doi: 10.1186/s12885-021-07844-2. PubMed |
| Discovery of Zika virus host dependency factors in trophoblasts using CRISPR/Cas9 screening. Rother M, Dimmler C, Weege F, Mollenkopf HJ, Meyer TF, Naumann M. J Virol Methods. 2021 Apr;290:114085. doi: 10.1016/j.jviromet.2021.114085. Epub 2021 Feb 2. PubMed |
| NAMPT/SIRT2-mediated inhibition of the p53-p21 signaling pathway is indispensable for maintenance and hematopoietic differentiation of human iPS cells. Xu Y, Nasri M, Dannenmann B, Mir P, Zahabi A, Welte K, Morishima T, Skokowa J. Stem Cell Res Ther. 2021 Feb 5;12(1):112. doi: 10.1186/s13287-021-02144-9. PubMed |
A pentameric protein ring with novel architecture is required for herpesviral packaging.
Didychuk AL, Gates SN, Gardner MR, Strong LM, Martin A, Glaunsinger BA.
Elife. 2021 Feb 8;10. pii: 62261. doi: 10.7554/eLife.62261.
PubMed
Associated Plasmids |
| SPRTN protease-cleaved MRE11 decreases DNA repair and radiosensitises cancer cells. Na J, Newman JA, Then CK, Syed J, Vendrell I, Torrecilla I, Ellermann S, Ramadan K, Fischer R, Kiltie AE. Cell Death Dis. 2021 Feb 8;12(2):165. doi: 10.1038/s41419-021-03437-w. PubMed |
| Identification of pannexin 1-regulated genes, interactome, and pathways in rhabdomyosarcoma and its tumor inhibitory interaction with AHNAK. Xiang X, Langlois S, St-Pierre ME, Blinder A, Charron P, Graber TE, Fowler SL, Baird SD, Bennett SAL, Alain T, Cowan KN. Oncogene. 2021 Mar;40(10):1868-1883. doi: 10.1038/s41388-020-01623-2. Epub 2021 Feb 9. PubMed |
| [Levels of sgRNA as a Major Factor Affecting CRISPRi Knockdown Efficiency in K562 Cells]. Wang Y, Xie Y, Dong ZC, Jiang XJ, Gong P, Lu J, Wan F. Mol Biol (Mosk). 2021 Jan-Feb;55(1):86-95. doi: 10.31857/S0026898421010146. PubMed |
| Gain-of-function p53 protein transferred via small extracellular vesicles promotes conversion of fibroblasts to a cancer-associated phenotype. Ma S, McGuire MH, Mangala LS, Lee S, Stur E, Hu W, Bayraktar E, Villar-Prados A, Ivan C, Wu SY, Yokoi A, Dasari SK, Jennings NB, Liu J, Lopez-Berestein G, Ram P, Sood AK. Cell Rep. 2021 Feb 9;34(6):108726. doi: 10.1016/j.celrep.2021.108726. PubMed |
| A conserved long noncoding RNA, GAPLINC, modulates the immune response during endotoxic shock. Vollmers AC, Covarrubias S, Kuang D, Shulkin A, Iwuagwu J, Katzman S, Song R, Viswanathan K, Vollmers C, Wakeland E, Carpenter S. Proc Natl Acad Sci U S A. 2021 Feb 16;118(7). pii: 2016648118. doi: 10.1073/pnas.2016648118. PubMed |
| LETR1 is a lymphatic endothelial-specific lncRNA governing cell proliferation and migration through KLF4 and SEMA3C. Ducoli L, Agrawal S, Sibler E, Kouno T, Tacconi C, Hon CC, Berger SD, Mullhaupt D, He Y, Kim J, D'Addio M, Dieterich LC, Carninci P, de Hoon MJL, Shin JW, Detmar M. Nat Commun. 2021 Feb 10;12(1):925. doi: 10.1038/s41467-021-21217-0. PubMed |
| Small molecule inhibitor of OGG1 blocks oxidative DNA damage repair at telomeres and potentiates methotrexate anticancer effects. Baquero JM, Benitez-Buelga C, Rajagopal V, Zhenjun Z, Torres-Ruiz R, Muller S, Hanna BMF, Loseva O, Wallner O, Michel M, Rodriguez-Perales S, Gad H, Visnes T, Helleday T, Benitez J, Osorio A. Sci Rep. 2021 Feb 10;11(1):3490. doi: 10.1038/s41598-021-82917-7. PubMed |
The Spike D614G mutation increases SARS-CoV-2 infection of multiple human cell types.
Daniloski Z, Jordan TX, Ilmain JK, Guo X, Bhabha G, tenOever BR, Sanjana NE.
Elife. 2021 Feb 11;10. pii: 65365. doi: 10.7554/eLife.65365.
PubMed
Associated Plasmids |
| Design of genetically encoded sensors to detect nucleosome ubiquitination in live cells. Dos Santos Passos C, Choi YS, Snow CD, Yao T, Cohen RE. J Cell Biol. 2021 Apr 5;220(4). pii: 211785. doi: 10.1083/jcb.201911130. PubMed |
| NOTCH1-driven UBR7 stimulates nucleotide biosynthesis to promote T cell acute lymphoblastic leukemia. Srivastava S, Sahu U, Zhou Y, Hogan AK, Sathyan KM, Bodner J, Huang J, Wong KA, Khalatyan N, Savas JN, Ntziachristos P, Ben-Sahra I, Foltz DR. Sci Adv. 2021 Jan 27;7(5). pii: 7/5/eabc9781. doi: 10.1126/sciadv.abc9781. Print 2021 Jan. PubMed |
| A synthetic mechanogenetic gene circuit for autonomous drug delivery in engineered tissues. Nims RJ, Pferdehirt L, Ho NB, Savadipour A, Lorentz J, Sohi S, Kassab J, Ross AK, O'Conor CJ, Liedtke WB, Zhang B, McNulty AL, Guilak F. Sci Adv. 2021 Jan 27;7(5). pii: 7/5/eabd9858. doi: 10.1126/sciadv.abd9858. Print 2021 Jan. PubMed |
| The IMiD target CRBN determines HSP90 activity toward transmembrane proteins essential in multiple myeloma. Heider M, Eichner R, Stroh J, Morath V, Kuisl A, Zecha J, Lawatscheck J, Baek K, Garz AK, Rudelius M, Deuschle FC, Keller U, Lemeer S, Verbeek M, Gotze KS, Skerra A, Weber WA, Buchner J, Schulman BA, Kuster B, Fernandez-Saiz V, Bassermann F. Mol Cell. 2021 Mar 18;81(6):1170-1186.e10. doi: 10.1016/j.molcel.2020.12.046. Epub 2021 Feb 10. PubMed |
| A genome-wide CRISPR screen identifies host factors that regulate SARS-CoV-2 entry. Zhu Y, Feng F, Hu G, Wang Y, Yu Y, Zhu Y, Xu W, Cai X, Sun Z, Han W, Ye R, Qu D, Ding Q, Huang X, Chen H, Xu W, Xie Y, Cai Q, Yuan Z, Zhang R. Nat Commun. 2021 Feb 11;12(1):961. doi: 10.1038/s41467-021-21213-4. PubMed |
The ubiquitin isopeptidase USP10 deubiquitinates LC3B to increase LC3B levels and autophagic activity.
Jia R, Bonifacino JS.
J Biol Chem. 2021 Jan-Jun;296:100405. doi: 10.1016/j.jbc.2021.100405. Epub 2021 Feb 10.
PubMed
Associated Plasmids |
| Signal peptidase complex subunit 1 is an essential Zika virus host factor in placental trophoblasts. Rother M, Naumann M. Virus Res. 2021 Apr 15;296:198338. doi: 10.1016/j.virusres.2021.198338. Epub 2021 Feb 9. PubMed |
| Insights into neutralizing antibody responses in individuals exposed to SARS-CoV-2 in Chile. Beltran-Pavez C, Riquelme-Barrios S, Oyarzun-Arrau A, Gaete-Argel A, Gonzalez-Stegmaier R, Cereceda-Solis K, Aguirre A, Travisany D, Palma-Vejares R, Barriga GP, Gaggero A, Martinez-Valdebenito C, Corre NL, Ferres M, Balcells ME, Fernandez J, Ramirez E, Villarroel F, Valiente-Echeverria F, Soto-Rifo R. Sci Adv. 2021 Feb 12;7(7). pii: 7/7/eabe6855. doi: 10.1126/sciadv.abe6855. Print 2021 Feb. PubMed |
| FGF8 and BMP2 mediated dynamic regulation of dental mesenchyme proliferation and differentiation via Lhx8/Suv39h1 complex. Zhou C, Chen D, Ren J, Huang D, Li R, Luo H, Guan C, Cao Y, Wang W. J Cell Mol Med. 2021 Mar;25(6):3051-3062. doi: 10.1111/jcmm.16351. Epub 2021 Feb 13. PubMed |
| Identification of a long non-coding RNA regulator of liver carcinoma cell survival. Rybakova Y, Gonzalez JT, Bogorad R, Chauhan VP, Dong YL, Whittaker CA, Zatsepin T, Koteliansky V, Anderson DG. Cell Death Dis. 2021 Feb 15;12(2):178. doi: 10.1038/s41419-021-03453-w. PubMed |
| Palladin isoforms 3 and 4 regulate cancer-associated fibroblast pro-tumor functions in pancreatic ductal adenocarcinoma. Alexander JI, Vendramini-Costa DB, Francescone R, Luong T, Franco-Barraza J, Shah N, Gardiner JC, Nicolas E, Raghavan KS, Cukierman E. Sci Rep. 2021 Feb 15;11(1):3802. doi: 10.1038/s41598-021-82937-3. PubMed |
| Lysophospholipid acylation modulates plasma membrane lipid organization and insulin sensitivity in skeletal muscle. Ferrara PJ, Rong X, Maschek JA, Verkerke AR, Siripoksup P, Song H, Green TD, Krishnan KC, Johnson JM, Turk J, Houmard JA, Lusis AJ, Drummond MJ, McClung JM, Cox JE, Shaikh SR, Tontonoz P, Holland WL, Funai K. J Clin Invest. 2021 Apr 15;131(8). pii: 135963. doi: 10.1172/JCI135963. PubMed |
| Centrosome amplification mediates small extracellular vesicle secretion via lysosome disruption. Adams SD, Csere J, D'angelo G, Carter EP, Romao M, Arnandis T, Dodel M, Kocher HM, Grose R, Raposo G, Mardakheh F, Godinho SA. Curr Biol. 2021 Apr 12;31(7):1403-1416.e7. doi: 10.1016/j.cub.2021.01.028. Epub 2021 Feb 15. PubMed |
| Modulating HSF1 levels impacts expression of the estrogen receptor alpha and antiestrogen response. Silveira MA, Tav C, Berube-Simard FA, Cuppens T, Leclercq M, Fournier E, Cote MC, Droit A, Bilodeau S. Life Sci Alliance. 2021 Feb 16;4(5). pii: 4/5/e202000811. doi: 10.26508/lsa.202000811. Print 2021 May. PubMed |
| Telomeres reforged with non-telomeric sequences in mouse embryonic stem cells. Kim C, Sung S, Kim JS, Lee H, Jung Y, Shin S, Kim E, Seo JJ, Kim J, Kim D, Niida H, Kim VN, Park D, Lee J. Nat Commun. 2021 Feb 17;12(1):1097. doi: 10.1038/s41467-021-21341-x. PubMed |
| Autophagy buffers Ras-induced genotoxic stress enabling malignant transformation in keratinocytes primed by human papillomavirus. Cararo-Lopes E, Dias MH, da Silva MS, Zeidler JD, Vessoni AT, Reis MS, Boccardo E, Armelin HA. Cell Death Dis. 2021 Feb 18;12(2):194. doi: 10.1038/s41419-021-03476-3. PubMed |
| STIM2 Mediates Excessive Store-Operated Calcium Entry in Patient-Specific iPSC-Derived Neurons Modeling a Juvenile Form of Huntington's Disease. Vigont VA, Grekhnev DA, Lebedeva OS, Gusev KO, Volovikov EA, Skopin AY, Bogomazova AN, Shuvalova LD, Zubkova OA, Khomyakova EA, Glushankova LN, Klyushnikov SA, Illarioshkin SN, Lagarkova MA, Kaznacheyeva EV. Front Cell Dev Biol. 2021 Feb 2;9:625231. doi: 10.3389/fcell.2021.625231. eCollection 2021. PubMed |
| DGKA Mediates Resistance to PD-1 Blockade. Fu L, Li S, Xiao W, Yu K, Li S, Yuan S, Shen J, Dong X, Fang Z, Zhang J, Chen S, Li W, You H, Xia X, Kang T, Tan J, Chen G, Yang AK, Gao Y, Zhou P. Cancer Immunol Res. 2021 Apr;9(4):371-385. doi: 10.1158/2326-6066.CIR-20-0216. Epub 2021 Feb 19. PubMed |
| SARS-CoV-2 and SARS-CoV Spike-Mediated Cell-Cell Fusion Differ in Their Requirements for Receptor Expression and Proteolytic Activation. Hornich BF, Grosskopf AK, Schlagowski S, Tenbusch M, Kleine-Weber H, Neipel F, Stahl-Hennig C, Hahn AS. J Virol. 2021 Apr 12;95(9). pii: JVI.00002-21. doi: 10.1128/JVI.00002-21. Print 2021 Apr 12. PubMed |
| Genome-wide CRISPR/Cas9-knockout in human induced Pluripotent Stem Cell (iPSC)-derived macrophages. Navarro-Guerrero E, Tay C, Whalley JP, Cowley SA, Davies B, Knight JC, Ebner D. Sci Rep. 2021 Feb 19;11(1):4245. doi: 10.1038/s41598-021-82137-z. PubMed |
| miR-130a activates the VEGFR2/STAT3/HIF1alpha axis to potentiate the vasoregenerative capacity of endothelial colony-forming cells in hypoxia. Guduric-Fuchs J, Pedrini E, Lechner J, Chambers SEJ, O'Neill CL, Mendes Lopes de Melo J, Pathak V, Church RH, McKeown S, Bojdo J, Mcloughlin KJ, Stitt AW, Medina RJ. Mol Ther Nucleic Acids. 2021 Jan 20;23:968-981. doi: 10.1016/j.omtn.2021.01.015. eCollection 2021 Mar 5. PubMed |
| Differentiated glioblastoma cells accelerate tumor progression by shaping the tumor microenvironment via CCN1-mediated macrophage infiltration. Uneda A, Kurozumi K, Fujimura A, Fujii K, Ishida J, Shimazu Y, Otani Y, Tomita Y, Hattori Y, Matsumoto Y, Tsuboi N, Makino K, Hirano S, Kamiya A, Date I. Acta Neuropathol Commun. 2021 Feb 22;9(1):29. doi: 10.1186/s40478-021-01124-7. PubMed |
| Silencing of SRRM4 suppresses microexon inclusion and promotes tumor growth across cancers. Head SA, Hernandez-Alias X, Yang JS, Ciampi L, Beltran-Sastre V, Torres-Mendez A, Irimia M, Schaefer MH, Serrano L. PLoS Biol. 2021 Feb 23;19(2):e3001138. doi: 10.1371/journal.pbio.3001138. eCollection 2021 Feb. PubMed |
Efficient Immune Cell Genome Engineering with Enhanced CRISPR Editing Tools.
Chan W, Gottschalk RA, Yao Y, Pomerantz JL, Germain RN.
Immunohorizons. 2021 Feb 23;5(2):117-132. doi: 10.4049/immunohorizons.2000082.
PubMed
Associated Plasmids |
| SEC24A facilitates colocalization and Ca(2) (+) flux between the endoplasmic reticulum and mitochondria. Chidawanyika T, Chakrabarti R, Beauchemin KS, Higgs HN, Supattapone S. J Cell Sci. 2021 Mar 26;134(6). pii: jcs.249276. doi: 10.1242/jcs.249276. PubMed |
| Control of ribosomal protein synthesis by the Microprocessor complex. Jiang X, Prabhakar A, Van der Voorn SM, Ghatpande P, Celona B, Venkataramanan S, Calviello L, Lin C, Wang W, Black BL, Floor SN, Lagna G, Hata A. Sci Signal. 2021 Feb 23;14(671). pii: 14/671/eabd2639. doi: 10.1126/scisignal.abd2639. PubMed |
| Acquired cancer cell resistance to T cell bispecific antibodies and CAR T targeting HER2 through JAK2 down-modulation. Arenas EJ, Martinez-Sabadell A, Rius Ruiz I, Roman Alonso M, Escorihuela M, Luque A, Fajardo CA, Gros A, Klein C, Arribas J. Nat Commun. 2021 Feb 23;12(1):1237. doi: 10.1038/s41467-021-21445-4. PubMed |
| Accelerating target deconvolution for therapeutic antibody candidates using highly parallelized genome editing. Mattsson J, Ekdahl L, Junghus F, Ajore R, Erlandsson E, Niroula A, Pertesi M, Frendeus B, Teige I, Nilsson B. Nat Commun. 2021 Feb 24;12(1):1277. doi: 10.1038/s41467-021-21518-4. PubMed |
| In vivo CRISPR screening reveals nutrient signaling processes underpinning CD8(+) T cell fate decisions. Huang H, Zhou P, Wei J, Long L, Shi H, Dhungana Y, Chapman NM, Fu G, Saravia J, Raynor JL, Liu S, Palacios G, Wang YD, Qian C, Yu J, Chi H. Cell. 2021 Mar 4;184(5):1245-1261.e21. doi: 10.1016/j.cell.2021.02.021. Epub 2021 Feb 25. PubMed |
| Combinatorial CRISPR screen identifies fitness effects of gene paralogues. Thompson NA, Ranzani M, van der Weyden L, Iyer V, Offord V, Droop A, Behan F, Goncalves E, Speak A, Iorio F, Hewinson J, Harle V, Robertson H, Anderson E, Fu B, Yang F, Zagnoli-Vieira G, Chapman P, Del Castillo Velasco-Herrera M, Garnett MJ, Jackson SP, Adams DJ. Nat Commun. 2021 Feb 26;12(1):1302. doi: 10.1038/s41467-021-21478-9. PubMed |
| Distinct genetic pathways define pre-malignant versus compensatory clonal hematopoiesis in Shwachman-Diamond syndrome. Kennedy AL, Myers KC, Bowman J, Gibson CJ, Camarda ND, Furutani E, Muscato GM, Klein RH, Ballotti K, Liu S, Harris CE, Galvin A, Malsch M, Dale D, Gansner JM, Nakano TA, Bertuch A, Vlachos A, Lipton JM, Castillo P, Connelly J, Churpek J, Edwards JR, Hijiya N, Ho RH, Hofmann I, Huang JN, Keel S, Lamble A, Lau BW, Norkin M, Stieglitz E, Stock W, Walkovich K, Boettcher S, Brendel C, Fleming MD, Davies SM, Weller EA, Bahl C, Carter SL, Shimamura A, Lindsley RC. Nat Commun. 2021 Feb 26;12(1):1334. doi: 10.1038/s41467-021-21588-4. PubMed |
| Open-Label Study of the Influence of Food Containing the Royal Sun Mushroom, Agaricus brasiliensis KA21 (Agaricomycetes), on beta-Glucan-Specific Antibody Production in Healthy Human Volunteers. Yamanaka D, Shoda M, Matsubara T, Ishibashi KI, Motoi A, Motoi R, Motoi M, Ohno N, Adachi Y. Int J Med Mushrooms. 2021;23(2):13-28. doi: 10.1615/IntJMedMushrooms.2020037471. PubMed |
| The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals. Torrence ME, MacArthur MR, Hosios AM, Valvezan AJ, Asara JM, Mitchell JR, Manning BD. Elife. 2021 Mar 1;10. pii: 63326. doi: 10.7554/eLife.63326. PubMed |
| ACE2 receptor usage reveals variation in susceptibility to SARS-CoV and SARS-CoV-2 infection among bat species. Yan H, Jiao H, Liu Q, Zhang Z, Xiong Q, Wang BJ, Wang X, Guo M, Wang LF, Lan K, Chen Y, Zhao H. Nat Ecol Evol. 2021 May;5(5):600-608. doi: 10.1038/s41559-021-01407-1. Epub 2021 Mar 1. PubMed |
| Transcription factor competition at the gamma-globin promoters controls hemoglobin switching. Liu N, Xu S, Yao Q, Zhu Q, Kai Y, Hsu JY, Sakon P, Pinello L, Yuan GC, Bauer DE, Orkin SH. Nat Genet. 2021 Apr;53(4):511-520. doi: 10.1038/s41588-021-00798-y. Epub 2021 Mar 1. PubMed |
| Plxdc family members are novel receptors for the rhesus monkey rhadinovirus (RRV). Grosskopf AK, Schlagowski S, Fricke T, Ensser A, Desrosiers RC, Hahn AS. PLoS Pathog. 2021 Mar 3;17(3):e1008979. doi: 10.1371/journal.ppat.1008979. eCollection 2021 Mar. PubMed |
| Exosomes from human cord blood plasma accelerate cutaneous wound healing by promoting fibroblast function, angiogenesis, and M2 macrophage differentiation. Kim S, Kim Y, Hyun YS, Choi H, Kim SY, Kim TG. Biomater Sci. 2021 Apr 21;9(8):3028-3039. doi: 10.1039/d0bm01801e. Epub 2021 Mar 3. PubMed |
| Post-transcriptional regulation of antiviral gene expression by N6-methyladenosine. McFadden MJ, McIntyre ABR, Mourelatos H, Abell NS, Gokhale NS, Ipas H, Xhemalce B, Mason CE, Horner SM. Cell Rep. 2021 Mar 2;34(9):108798. doi: 10.1016/j.celrep.2021.108798. PubMed |
| Biophysical and biochemical properties of Deup1 self-assemblies: a potential driver for deuterosome formation during multiciliogenesis. Yamamoto S, Yabuki R, Kitagawa D. Biol Open. 2021 Mar 3;10(3). pii: 10/3/bio056432. doi: 10.1242/bio.056432. PubMed |
| Novel Secreted Protein of Mycoplasma bovis MbovP280 Induces Macrophage Apoptosis Through CRYAB. Zhao G, Zhu X, Zhang H, Chen Y, Schieck E, Hu C, Chen H, Guo A. Front Immunol. 2021 Feb 15;12:619362. doi: 10.3389/fimmu.2021.619362. eCollection 2021. PubMed |
| Presence of antibody-dependent cellular cytotoxicity (ADCC) against SARS-CoV-2 in COVID-19 plasma. Tso FY, Lidenge SJ, Poppe LK, Pena PB, Privatt SR, Bennett SJ, Ngowi JR, Mwaiselage J, Belshan M, Siedlik JA, Raine MA, Ochoa JB, Garcia-Diaz J, Nossaman B, Buckner L, Roberts WM, Dean MJ, Ochoa AC, West JT, Wood C. PLoS One. 2021 Mar 4;16(3):e0247640. doi: 10.1371/journal.pone.0247640. eCollection 2021. PubMed |
| In Silico, In Vitro and In Cellulo Models for Monitoring SARS-CoV-2 Spike/Human ACE2 Complex, Viral Entry and Cell Fusion. Lapaillerie D, Charlier C, Fernandes HS, Sousa SF, Lesbats P, Weigel P, Favereaux A, Guyonnet-Duperat V, Parissi V. Viruses. 2021 Feb 25;13(3). pii: v13030365. doi: 10.3390/v13030365. PubMed |
| Osteopontin Blockade Immunotherapy Increases Cytotoxic T Lymphocyte Lytic Activity and Suppresses Colon Tumor Progression. Klement JD, Poschel DB, Lu C, Merting AD, Yang D, Redd PS, Liu K. Cancers (Basel). 2021 Feb 28;13(5). pii: cancers13051006. doi: 10.3390/cancers13051006. PubMed |
| Role of Clathrin Light Chains in Regulating Invadopodia Formation. Mukenhirn M, Muraca F, Bucher D, Asberger E, Cappio Barazzone E, Cavalcanti-Adam EA, Boulant S. Cells. 2021 Feb 20;10(2). pii: cells10020451. doi: 10.3390/cells10020451. PubMed |
| Epigenetic regulation of p62/SQSTM1 overcomes the radioresistance of head and neck cancer cells via autophagy-dependent senescence induction. Lee M, Nam HY, Kang HB, Lee WH, Lee GH, Sung GJ, Han MW, Cho KJ, Chang EJ, Choi KC, Kim SW, Kim SY. Cell Death Dis. 2021 Mar 5;12(3):250. doi: 10.1038/s41419-021-03539-5. PubMed |
| ARID1A knockdown in human endothelial cells directly induces angiogenesis by regulating angiopoietin-2 secretion and endothelial cell activity. Yoodee S, Peerapen P, Plumworasawat S, Thongboonkerd V. Int J Biol Macromol. 2021 Jun 1;180:1-13. doi: 10.1016/j.ijbiomac.2021.02.218. Epub 2021 Mar 3. PubMed |
| Engineered IgG1-Fc Molecules Define Valency Control of Cell Surface Fcgamma Receptor Inhibition and Activation in Endosomes. Bailey EM, Choudhury A, Vuppula H, Ortiz DF, Schaeck J, Manning AM, Bosques CJ, Hoppe AD. Front Immunol. 2021 Feb 15;11:617767. doi: 10.3389/fimmu.2020.617767. eCollection 2020. PubMed |
| ORMDL3 Functions as a Negative Regulator of Antigen-Mediated Mast Cell Activation via an ATF6-UPR-Autophagy-Dependent Pathway. Li J, Ullah MA, Jin H, Liang Y, Lin L, Wang J, Peng X, Liao H, Li Y, Ge Y, Li L. Front Immunol. 2021 Feb 19;12:604974. doi: 10.3389/fimmu.2021.604974. eCollection 2021. PubMed |
| JMJD6 negatively regulates cytosolic RNA induced antiviral signaling by recruiting RNF5 to promote activated IRF3 K48 ubiquitination. Zhang W, Wang Q, Yang F, Zhu Z, Duan Y, Yang Y, Cao W, Zhang K, Ma J, Liu X, Zheng H. PLoS Pathog. 2021 Mar 8;17(3):e1009366. doi: 10.1371/journal.ppat.1009366. eCollection 2021 Mar. PubMed |
| C11orf95-RELA fusion drives aberrant gene expression through the unique epigenetic regulation for ependymoma formation. Ozawa T, Kaneko S, Szulzewsky F, Qiao Z, Takadera M, Narita Y, Kondo T, Holland EC, Hamamoto R, Ichimura K. Acta Neuropathol Commun. 2021 Mar 8;9(1):36. doi: 10.1186/s40478-021-01135-4. PubMed |
| Lin28 Inhibits the Differentiation from Mouse Embryonic Stem Cells to Glial Lineage Cells through Upregulation of Yap1. Luo J, Zou H, Deng L, Sun X, Yuan P, Li P. Stem Cells Int. 2021 Feb 22;2021:6674283. doi: 10.1155/2021/6674283. eCollection 2021. PubMed |
| Biofabrication of a three dimensional human-based personalized neurofibroma model. Roy V, Lamontagne R, Talagas M, Touzel-Deschenes L, Khuong HT, Saikali S, Dupre N, Gros-Louis F. Biotechnol J. 2021 Jun;16(6):e2000250. doi: 10.1002/biot.202000250. Epub 2021 Apr 7. PubMed |
| Identification of pathogenic variants in cancer genes using base editing screens with editing efficiency correction. Huang C, Li G, Wu J, Liang J, Wang X. Genome Biol. 2021 Mar 10;22(1):80. doi: 10.1186/s13059-021-02305-2. PubMed |
| A robust method for protein depletion based on gene editing. Yang Y, Wu W, Liu T, Dong L, Lei H. Methods. 2021 Oct;194:3-11. doi: 10.1016/j.ymeth.2021.03.001. Epub 2021 Mar 8. PubMed |
| SIRT3 consolidates heterochromatin and counteracts senescence. Diao Z, Ji Q, Wu Z, Zhang W, Cai Y, Wang Z, Hu J, Liu Z, Wang Q, Bi S, Huang D, Ji Z, Liu GH, Wang S, Song M, Qu J. Nucleic Acids Res. 2021 May 7;49(8):4203-4219. doi: 10.1093/nar/gkab161. PubMed |
| A novel cell culture system modeling the SARS-CoV-2 life cycle. Ju X, Zhu Y, Wang Y, Li J, Zhang J, Gong M, Ren W, Li S, Zhong J, Zhang L, Zhang QC, Zhang R, Ding Q. PLoS Pathog. 2021 Mar 12;17(3):e1009439. doi: 10.1371/journal.ppat.1009439. eCollection 2021 Mar. PubMed |
| Heparan sulfates from bat and human lung and their binding to the spike protein of SARS-CoV-2 virus. Yan L, Song Y, Xia K, He P, Zhang F, Chen S, Pouliot R, Weiss DJ, Tandon R, Bates JT, Ederer DR, Mitra D, Sharma P, Davis A, Linhardt RJ. Carbohydr Polym. 2021 May 15;260:117797. doi: 10.1016/j.carbpol.2021.117797. Epub 2021 Feb 14. PubMed |
| Creb5 establishes the competence for Prg4 expression in articular cartilage. Zhang CH, Gao Y, Jadhav U, Hung HH, Holton KM, Grodzinsky AJ, Shivdasani RA, Lassar AB. Commun Biol. 2021 Mar 12;4(1):332. doi: 10.1038/s42003-021-01857-0. PubMed |
| FLI1 Induces Megakaryopoiesis Gene Expression Through WAS/WIP-Dependent and Independent Mechanisms; Implications for Wiskott-Aldrich Syndrome. Wang C, Sample KM, Gajendran B, Kapranov P, Liu W, Hu A, Zacksenhaus E, Li Y, Hao X, Ben-David Y. Front Immunol. 2021 Feb 26;12:607836. doi: 10.3389/fimmu.2021.607836. eCollection 2021. PubMed |
| Pin1 Promotes NLRP3 Inflammasome Activation by Phosphorylation of p38 MAPK Pathway in Septic Shock. Dong R, Xue Z, Fan G, Zhang N, Wang C, Li G, Da Y. Front Immunol. 2021 Feb 25;12:620238. doi: 10.3389/fimmu.2021.620238. eCollection 2021. PubMed |
| The Crucial Role of PPARgamma-Egr-1-Pro-Inflammatory Mediators Axis in IgG Immune Complex-Induced Acute Lung Injury. Yan C, Chen J, Ding Y, Zhou Z, Li B, Deng C, Yuan D, Zhang Q, Wang X. Front Immunol. 2021 Feb 25;12:634889. doi: 10.3389/fimmu.2021.634889. eCollection 2021. PubMed |
| Sall4 and Myocd Empower Direct Cardiac Reprogramming From Adult Cardiac Fibroblasts After Injury. Zhao H, Zhang Y, Xu X, Sun Q, Yang C, Wang H, Yang J, Yang Y, Yang X, Liu Y, Zhao Y. Front Cell Dev Biol. 2021 Feb 26;9:608367. doi: 10.3389/fcell.2021.608367. eCollection 2021. PubMed |
| Effective, safe, and sustained correction of murine XLA using a UCOE-BTK promoter-based lentiviral vector. Seymour BJ, Singh S, Certo HM, Sommer K, Sather BD, Khim S, Clough C, Hale M, Pangallo J, Ryu BY, Khan IF, Adair JE, Rawlings DJ. Mol Ther Methods Clin Dev. 2021 Jan 20;20:635-651. doi: 10.1016/j.omtm.2021.01.007. eCollection 2021 Mar 12. PubMed |
| Positive feedback regulation between USP15 and ERK2 inhibits osteoarthritis progression through TGF-beta/SMAD2 signaling. Wang W, Zhu Y, Sun Z, Jin C, Wang X. Arthritis Res Ther. 2021 Mar 16;23(1):84. doi: 10.1186/s13075-021-02456-4. PubMed |
| Engineering T Cells to Express Tumoricidal MDA-7/IL24 Enhances Cancer Immunotherapy. Liu Z, Guo C, Das SK, Yu X, Pradhan AK, Li X, Ning Y, Chen S, Liu W, Windle JJ, Bear HD, Manjili MH, Fisher PB, Wang XY. Cancer Res. 2021 May 1;81(9):2429-2441. doi: 10.1158/0008-5472.CAN-20-2604. Epub 2021 Mar 16. PubMed |
| Deletion of the SARS-CoV-2 Spike Cytoplasmic Tail Increases Infectivity in Pseudovirus Neutralization Assays. Yu J, Li Z, He X, Gebre MS, Bondzie EA, Wan H, Jacob-Dolan C, Martinez DR, Nkolola JP, Baric RS, Barouch DH. J Virol. 2021 Mar 16. pii: JVI.00044-21. doi: 10.1128/JVI.00044-21. PubMed |
| Aberrant Claudin-6-Adhesion Signaling Promotes Endometrial Cancer Progression via Estrogen Receptor alpha. Kojima M, Sugimoto K, Kobayashi M, Ichikawa-Tomikawa N, Kashiwagi K, Watanabe T, Soeda S, Fujimori K, Chiba H. Mol Cancer Res. 2021 Jul;19(7):1208-1220. doi: 10.1158/1541-7786.MCR-20-0835. Epub 2021 Mar 16. PubMed |
| ACK1 is dispensable for development, skin tumor formation, and breast cancer cell proliferation. Brandao R, Kwa MQ, Yarden Y, Brakebusch C. FEBS Open Bio. 2021 Jun;11(6):1579-1592. doi: 10.1002/2211-5463.13149. Epub 2021 May 2. PubMed |
| RNA decay in processing bodies is indispensable for adipogenesis. Maeda R, Kami D, Shikuma A, Suzuki Y, Taya T, Matoba S, Gojo S. Cell Death Dis. 2021 Mar 17;12(4):285. doi: 10.1038/s41419-021-03537-7. PubMed |
| Construction of differential expression plasmids of NGF to detect its influence on PC12 cell neuronal differentiation. Liu Y, Zou L, Wang P, Zhou J, Yuan C, Wang J. Exp Ther Med. 2021 Apr;21(4):363. doi: 10.3892/etm.2021.9794. Epub 2021 Feb 14. PubMed |
| HSP90 inhibitor NVP-BEP800 affects stability of SRC kinases and growth of T-cell and B-cell acute lymphoblastic leukemias. Mshaik R, Simonet J, Georgievski A, Jamal L, Bechoua S, Ballerini P, Bellaye PS, Mlamla Z, Pais de Barros JP, Geissler A, Francin PJ, Girodon F, Garrido C, Quere R. Blood Cancer J. 2021 Mar 18;11(3):61. doi: 10.1038/s41408-021-00450-2. PubMed |
| CRISPRi screens reveal a DNA methylation-mediated 3D genome dependent causal mechanism in prostate cancer. Ahmed M, Soares F, Xia JH, Yang Y, Li J, Guo H, Su P, Tian Y, Lee HJ, Wang M, Akhtar N, Houlahan KE, Bosch A, Zhou S, Mazrooei P, Hua JT, Chen S, Petricca J, Zeng Y, Davies A, Fraser M, Quigley DA, Feng FY, Boutros PC, Lupien M, Zoubeidi A, Wang L, Walsh MJ, Wang T, Ren S, Wei GH, He HH. Nat Commun. 2021 Mar 19;12(1):1781. doi: 10.1038/s41467-021-21867-0. PubMed |
| Human Cytomegalovirus miR-US33as-5p Targets IFNAR1 to Achieve Immune Evasion During Both Lytic and Latent Infection. Zhang Q, Song X, Ma P, Lv L, Zhang Y, Deng J, Zhang Y. Front Immunol. 2021 Mar 5;12:628364. doi: 10.3389/fimmu.2021.628364. eCollection 2021. PubMed |
| Dysregulation of mitochondria-lysosome contacts by GBA1 dysfunction in dopaminergic neuronal models of Parkinson's disease. Kim S, Wong YC, Gao F, Krainc D. Nat Commun. 2021 Mar 22;12(1):1807. doi: 10.1038/s41467-021-22113-3. PubMed |
| A hierarchical regulatory network analysis of the vitamin D induced transcriptome reveals novel regulators and complete VDR dependency in monocytes. Warwick T, Schulz MH, Gunther S, Gilsbach R, Neme A, Carlberg C, Brandes RP, Seuter S. Sci Rep. 2021 Mar 22;11(1):6518. doi: 10.1038/s41598-021-86032-5. PubMed |
| Mutant ASXL1 induces age-related expansion of phenotypic hematopoietic stem cells through activation of Akt/mTOR pathway. Fujino T, Goyama S, Sugiura Y, Inoue D, Asada S, Yamasaki S, Matsumoto A, Yamaguchi K, Isobe Y, Tsuchiya A, Shikata S, Sato N, Morinaga H, Fukuyama T, Tanaka Y, Fukushima T, Takeda R, Yamamoto K, Honda H, Nishimura EK, Furukawa Y, Shibata T, Abdel-Wahab O, Suematsu M, Kitamura T. Nat Commun. 2021 Mar 23;12(1):1826. doi: 10.1038/s41467-021-22053-y. PubMed |
| Comparative analysis reveals the species-specific genetic determinants of ACE2 required for SARS-CoV-2 entry. Ren W, Zhu Y, Wang Y, Shi H, Yu Y, Hu G, Feng F, Zhao X, Lan J, Wu J, Kenney DJ, Douam F, Tong Y, Zhong J, Xie Y, Wang X, Yuan Z, Zhou D, Zhang R, Ding Q. PLoS Pathog. 2021 Mar 24;17(3):e1009392. doi: 10.1371/journal.ppat.1009392. eCollection 2021 Mar. PubMed |
| SH3BP4 promotes neuropilin-1 and alpha5-integrin endocytosis and is inhibited by Akt. Burckhardt CJ, Minna JD, Danuser G. Dev Cell. 2021 Apr 19;56(8):1164-1181.e12. doi: 10.1016/j.devcel.2021.03.009. Epub 2021 Mar 23. PubMed |
| HIF1alpha/HIF2alpha-Sox2/Klf4 promotes the malignant progression of glioblastoma via the EGFR-PI3K/AKT signalling pathway with positive feedback under hypoxia. Wang P, Zhao L, Gong S, Xiong S, Wang J, Zou D, Pan J, Deng Y, Yan Q, Wu N, Liao B. Cell Death Dis. 2021 Mar 24;12(4):312. doi: 10.1038/s41419-021-03598-8. PubMed |
WWTR1(TAZ)-CAMTA1 reprograms endothelial cells to drive epithelioid hemangioendothelioma.
Driskill JH, Zheng Y, Wu BK, Wang L, Cai J, Rakheja D, Dellinger M, Pan D.
Genes Dev. 2021 Apr 1;35(7-8):495-511. doi: 10.1101/gad.348221.120. Epub 2021 Mar 25.
PubMed
Associated Plasmids |
| A genome-scale CRISPR Cas9 dropout screen identifies synthetically lethal targets in SRC-3 inhibited cancer cells. Gilad Y, Eliaz Y, Yu Y, Dean AM, Han SJ, Qin L, O'Malley BW, Lonard DM. Commun Biol. 2021 Mar 25;4(1):399. doi: 10.1038/s42003-021-01929-1. PubMed |
| The tumor suppressor kinase DAPK3 drives tumor-intrinsic immunity through the STING-IFN-beta pathway. Takahashi M, Lio CJ, Campeau A, Steger M, Ay F, Mann M, Gonzalez DJ, Jain M, Sharma S. Nat Immunol. 2021 Apr;22(4):485-496. doi: 10.1038/s41590-021-00896-3. Epub 2021 Mar 25. PubMed |
| IgV somatic mutation of human anti-SARS-CoV-2 monoclonal antibodies governs neutralization and breadth of reactivity. de Mattos Barbosa MG, Liu H, Huynh D, Shelley G, Keller ET, Emmer BT, Sherman E, Ginsburg D, Kennedy AA, Tai AW, Wobus C, Mirabeli C, Lanigan TM, Samaniego M, Meng W, Rosenfeld AM, Prak ETL, Platt JL, Cascalho M. JCI Insight. 2021 May 10;6(9). pii: 147386. doi: 10.1172/jci.insight.147386. PubMed |
| USP22 promotes melanoma and BRAF inhibitor resistance via YAP stabilization. Wei Y, Jiang Z, Lu J. Oncol Lett. 2021 May;21(5):394. doi: 10.3892/ol.2021.12655. Epub 2021 Mar 18. PubMed |
| A Role for Polo-Like Kinase 4 in Vascular Fibroblast Cell-Type Transition. Li J, Urabe G, Huang Y, Zhang M, Wang B, Marcho L, Shen H, Kent KC, Guo LW. JACC Basic Transl Sci. 2021 Mar 22;6(3):257-283. doi: 10.1016/j.jacbts.2020.12.015. eCollection 2021 Mar. PubMed |
| Sensitivity of cells to ATR and CHK1 inhibitors requires hyperactivation of CDK2 rather than endogenous replication stress or ATM dysfunction. Ditano JP, Donahue KL, Tafe LJ, McCleery CF, Eastman A. Sci Rep. 2021 Mar 29;11(1):7077. doi: 10.1038/s41598-021-86490-x. PubMed |
| Podoplanin is required for tumor cell invasion in cutaneous squamous cell carcinoma. Schwab M, Lohr S, Schneider J, Kaiser M, Krunic D, Helbig D, Geraud C, Angel P. Exp Dermatol. 2021 Mar 30. doi: 10.1111/exd.14344. PubMed |
| A modified parachute assay for assessment of gap junction intercellular communication in placental trophoblast cells. Gingrich J, Pu Y, Veiga-Lopez A. Toxicol Mech Methods. 2021 Jun;31(5):393-399. doi: 10.1080/15376516.2021.1904072. Epub 2021 Mar 30. PubMed |
| RANK signaling increases after anti-HER2 therapy contributing to the emergence of resistance in HER2-positive breast cancer. Sanz-Moreno A, Palomeras S, Pedersen K, Morancho B, Pascual T, Galvan P, Benitez S, Gomez-Miragaya J, Ciscar M, Jimenez M, Pernas S, Petit A, Soler-Monso MT, Vinas G, Alsaleem M, Rakha EA, Green AR, Santamaria PG, Mulder C, Lemeer S, Arribas J, Prat A, Puig T, Gonzalez-Suarez E. Breast Cancer Res. 2021 Mar 30;23(1):42. doi: 10.1186/s13058-021-01390-2. PubMed |
| PPP6C negatively regulates oncogenic ERK signaling through dephosphorylation of MEK. Cho E, Lou HJ, Kuruvilla L, Calderwood DA, Turk BE. Cell Rep. 2021 Mar 30;34(13):108928. doi: 10.1016/j.celrep.2021.108928. PubMed |
| RIPK2 is an unfavorable prognosis marker and a potential therapeutic target in human kidney renal clear cell carcinoma. Li D, Tang L, Liu B, Xu S, Jin M, Bo W. Aging (Albany NY). 2021 Mar 31;13(7):10450-10467. doi: 10.18632/aging.202808. Epub 2021 Mar 31. PubMed |
| Oncogenic mutation or overexpression of oncogenic KRAS or BRAF is not sufficient to confer oncogene addiction. Ito RE, Oneyama C, Aoki K. PLoS One. 2021 Apr 1;16(4):e0249388. doi: 10.1371/journal.pone.0249388. eCollection 2021. PubMed |
| Control of endothelial quiescence by FOXO-regulated metabolites. Andrade J, Shi C, Costa ASH, Choi J, Kim J, Doddaballapur A, Sugino T, Ong YT, Castro M, Zimmermann B, Kaulich M, Guenther S, Wilhelm K, Kubota Y, Braun T, Koh GY, Grosso AR, Frezza C, Potente M. Nat Cell Biol. 2021 Apr;23(4):413-423. doi: 10.1038/s41556-021-00637-6. Epub 2021 Apr 1. PubMed |
| m(6)A-independent genome-wide METTL3 and METTL14 redistribution drives the senescence-associated secretory phenotype. Liu P, Li F, Lin J, Fukumoto T, Nacarelli T, Hao X, Kossenkov AV, Simon MC, Zhang R. Nat Cell Biol. 2021 Apr;23(4):355-365. doi: 10.1038/s41556-021-00656-3. Epub 2021 Apr 1. PubMed |
| Generation and Implementation of Reporter BHK-21 Cells for Live Imaging of Flavivirus Infection. Arias-Arias JL, Mora-Rodriguez R. Bio Protoc. 2021 Mar 5;11(5):e3942. doi: 10.21769/BioProtoc.3942. eCollection 2021 Mar 5. PubMed |
| Soluble JAM-C Ectodomain Serves as the Niche for Adipose-Derived Stromal/Stem Cells. Yamazaki M, Sugimoto K, Mabuchi Y, Yamashita R, Ichikawa-Tomikawa N, Kaneko T, Akazawa C, Hasegawa H, Imura T, Chiba H. Biomedicines. 2021 Mar 10;9(3). pii: biomedicines9030278. doi: 10.3390/biomedicines9030278. PubMed |
| Direct Generation of Immortalized Erythroid Progenitor Cell Lines from Peripheral Blood Mononuclear Cells. Bagchi A, Nath A, Thamodaran V, Ijee S, Palani D, Rajendiran V, Venkatesan V, Datari P, Pai AA, Janet NB, Balasubramanian P, Nakamura Y, Srivastava A, Mohankumar KM, Thangavel S, Velayudhan SR. Cells. 2021 Mar 1;10(3). pii: cells10030523. doi: 10.3390/cells10030523. PubMed |
| HIF-1alpha and Pro-Inflammatory Signaling Improves the Immunomodulatory Activity of MSC-Derived Extracellular Vesicles. Gomez-Ferrer M, Villanueva-Badenas E, Sanchez-Sanchez R, Sanchez-Lopez CM, Baquero MC, Sepulveda P, Dorronsoro A. Int J Mol Sci. 2021 Mar 26;22(7). pii: ijms22073416. doi: 10.3390/ijms22073416. PubMed |
| YTHDF1 Aggravates the Progression of Cervical Cancer Through m(6)A-Mediated Up-Regulation of RANBP2. Wang H, Luo Q, Kang J, Wei Q, Yang Y, Yang D, Liu X, Liu T, Yi P. Front Oncol. 2021 Mar 19;11:650383. doi: 10.3389/fonc.2021.650383. eCollection 2021. PubMed |
| The mitochondrial Ca(2+) uptake regulator, MICU1, is involved in cold stress-induced ferroptosis. Nakamura T, Ogawa M, Kojima K, Takayanagi S, Ishihara S, Hattori K, Naguro I, Ichijo H. EMBO Rep. 2021 May 5;22(5):e51532. doi: 10.15252/embr.202051532. Epub 2021 Apr 6. PubMed |
| Establishment and characterization of an immortalized epicardial cell line. Jiang H, Song S, Li J, Yin Q, Hu S, Nie Y. J Cell Mol Med. 2021 Apr 6. doi: 10.1111/jcmm.16496. PubMed |
| Gene Editing in Human Induced Pluripotent Stem Cells Using Doxycycline-Inducible CRISPR-Cas9 System. Thamodaran V, Rani S, Velayudhan SR. Methods Mol Biol. 2021 Apr 9. doi: 10.1007/7651_2021_348. PubMed |
| SARS-CoV-2 evolution in an immunocompromised host reveals shared neutralization escape mechanisms. Clark SA, Clark LE, Pan J, Coscia A, McKay LGA, Shankar S, Johnson RI, Brusic V, Choudhary MC, Regan J, Li JZ, Griffiths A, Abraham J. Cell. 2021 May 13;184(10):2605-2617.e18. doi: 10.1016/j.cell.2021.03.027. Epub 2021 Mar 16. PubMed |
| Therapeutic targeting of FOS in mutant TERT cancers through removing TERT suppression of apoptosis via regulating survivin and TRAIL-R2. Liu R, Tan J, Shen X, Jiang K, Wang C, Zhu G, Xing M. Proc Natl Acad Sci U S A. 2021 Mar 16;118(11):e2022779118. doi: 10.1073/pnas.2022779118. PubMed |
| Disruption of the MSL complex inhibits tumour maintenance by exacerbating chromosomal instability. Monserrat J, Morales Torres C, Richardson L, Wilson TS, Patel H, Domart MC, Horswell S, Song OR, Jiang M, Crawford M, Bui M, Dalal Y, Scaffidi P. Nat Cell Biol. 2021 Apr;23(4):401-412. doi: 10.1038/s41556-021-00657-2. Epub 2021 Apr 9. PubMed |
| In vivo measurement of extracellular dopamine and DOPAC in rat striatum after various dopamine-releasing drugs; implications for the origin of extracellular DOPAC. Zetterstrom T, Sharp T, Collin AK, Ungerstedt U. Eur J Pharmacol. 1988 Apr 13;148(3):327-34. PubMed |
| Directed Evolution of Stabilized Monomeric CD19 for Monovalent CAR Interaction Studies and Monitoring of CAR-T Cell Patients. Laurent E, Sieber A, Salzer B, Wachernig A, Seigner J, Lehner M, Geyeregger R, Kratzer B, Jager U, Kunert R, Pickl WF, Traxlmayr MW. ACS Synth Biol. 2021 May 21;10(5):1184-1198. doi: 10.1021/acssynbio.1c00010. Epub 2021 Apr 12. PubMed |
| Genome-wide screens uncover KDM2B as a modifier of protein binding to heparan sulfate. Weiss RJ, Spahn PN, Chiang AWT, Liu Q, Li J, Hamill KM, Rother S, Clausen TM, Hoeksema MA, Timm BM, Godula K, Glass CK, Tor Y, Gordts PLSM, Lewis NE, Esko JD. Nat Chem Biol. 2021 Jun;17(6):684-692. doi: 10.1038/s41589-021-00776-9. Epub 2021 Apr 12. PubMed |
| Protein acylation by saturated very long chain fatty acids and endocytosis are involved in necroptosis. Pradhan AJ, Lu D, Parisi LR, Shen S, Berhane IA, Galster SL, Bynum K, Monje-Galvan V, Gokcumen O, Chemler SR, Qu J, Kay JG, Atilla-Gokcumen GE. Cell Chem Biol. 2021 Sep 16;28(9):1298-1309.e7. doi: 10.1016/j.chembiol.2021.03.012. Epub 2021 Apr 12. PubMed |
| Repeated mutation of a developmental enhancer contributed to human thermoregulatory evolution. Aldea D, Atsuta Y, Kokalari B, Schaffner SF, Prasasya RD, Aharoni A, Dingwall HL, Warder B, Kamberov YG. Proc Natl Acad Sci U S A. 2021 Apr 20;118(16). pii: 2021722118. doi: 10.1073/pnas.2021722118. PubMed |
| An ultra-high-affinity small organic ligand of fibroblast activation protein for tumor-targeting applications. Millul J, Bassi G, Mock J, Elsayed A, Pellegrino C, Zana A, Dakhel Plaza S, Nadal L, Gloger A, Schmidt E, Biancofiore I, Donckele EJ, Samain F, Neri D, Cazzamalli S. Proc Natl Acad Sci U S A. 2021 Apr 20;118(16):e2101852118. doi: 10.1073/pnas.2101852118. PubMed |
| Seed-mediated RNA interference of androgen signaling and survival networks induces cell death in prostate cancer cells. Corbin JM, Georgescu C, Wren JD, Xu C, Asch AS, Ruiz-Echevarria MJ. Mol Ther Nucleic Acids. 2021 Mar 5;24:337-351. doi: 10.1016/j.omtn.2021.03.002. eCollection 2021 Jun 4. PubMed |
| Engrailed-2 is a cell autonomous regulator of neurogenesis in cultured hippocampal neural stem cells. Durens M, Soliman M, Millonig J, DiCicco-Bloom E. Dev Neurobiol. 2021 Jul;81(5):724-735. doi: 10.1002/dneu.22824. Epub 2021 May 5. PubMed |
| In situ architecture of neuronal alpha-Synuclein inclusions. Trinkaus VA, Riera-Tur I, Martinez-Sanchez A, Bauerlein FJB, Guo Q, Arzberger T, Baumeister W, Dudanova I, Hipp MS, Hartl FU, Fernandez-Busnadiego R. Nat Commun. 2021 Apr 14;12(1):2110. doi: 10.1038/s41467-021-22108-0. PubMed |
| Deficiency of Ku Induces Host Cell Exploitation in Human Cancer Cells. Saydam O, Saydam N. Front Cell Dev Biol. 2021 Mar 29;9:651818. doi: 10.3389/fcell.2021.651818. eCollection 2021. PubMed |
| SOD1 regulates ribosome biogenesis in KRAS mutant non-small cell lung cancer. Wang X, Zhang H, Sapio R, Yang J, Wong J, Zhang X, Guo JY, Pine S, Van Remmen H, Li H, White E, Liu C, Kiledjian M, Pestov DG, Steven Zheng XF. Nat Commun. 2021 Apr 15;12(1):2259. doi: 10.1038/s41467-021-22480-x. PubMed |
| Genome wide CRISPR screening reveals a role for sialylation in the tumorigenesis and chemoresistance of acute myeloid leukemia cells. Lee DH, Kang SH, Choi DS, Ko M, Choi E, Ahn H, Min H, Oh SJ, Lee MS, Park Y, Jin HS. Cancer Lett. 2021 Jul 10;510:37-47. doi: 10.1016/j.canlet.2021.04.006. Epub 2021 Apr 16. PubMed |
| Targeting Triple-Negative Breast Cancer with Combination Therapy of EGFR CAR T Cells and CDK7 Inhibition. Xia L, Zheng Z, Liu JY, Chen YJ, Ding J, Hu GS, Hu YH, Liu S, Luo WX, Xia NS, Liu W. Cancer Immunol Res. 2021 Jun;9(6):707-722. doi: 10.1158/2326-6066.CIR-20-0405. Epub 2021 Apr 19. PubMed |
| STING enhances cell death through regulation of reactive oxygen species and DNA damage. Hayman TJ, Baro M, MacNeil T, Phoomak C, Aung TN, Cui W, Leach K, Iyer R, Challa S, Sandoval-Schaefer T, Burtness BA, Rimm DL, Contessa JN. Nat Commun. 2021 Apr 19;12(1):2327. doi: 10.1038/s41467-021-22572-8. PubMed |
| Inherited deficiency of stress granule ZNFX1 in patients with monocytosis and mycobacterial disease. Le Voyer T, Neehus AL, Yang R, Ogishi M, Rosain J, Alroqi F, Alshalan M, Blumental S, Al Ali F, Khan T, Ata M, Rozen L, Demulder A, Bastard P, Gruber C, Roynard M, Seeleuthener Y, Rapaport F, Bigio B, Chrabieh M, Sng D, Berteloot L, Boddaert N, Rozenberg F, Al-Muhsen S, Bertoli-Avella A, Abel L, Bogunovic D, Marr N, Mansouri D, Al Mutairi F, Beziat V, Weil D, Mahdaviani SA, Ferster A, Zhang SY, Reversade B, Boisson-Dupuis S, Casanova JL, Bustamante J. Proc Natl Acad Sci U S A. 2021 Apr 13;118(15). pii: 2102804118. doi: 10.1073/pnas.2102804118. PubMed |
| PD-L1 tumor-intrinsic signaling and its therapeutic implication in triple-negative breast cancer. Chen C, Li S, Xue J, Qi M, Liu X, Huang Y, Hu J, Dong H, Ling K. JCI Insight. 2021 Apr 22;6(8). pii: 131458. doi: 10.1172/jci.insight.131458. PubMed |
| A BLOC-1-AP-3 super-complex sorts a cis-SNARE complex into endosome-derived tubular transport carriers. Bowman SL, Le L, Zhu Y, Harper DC, Sitaram A, Theos AC, Sviderskaya EV, Bennett DC, Raposo-Benedetti G, Owen DJ, Dennis MK, Marks MS. J Cell Biol. 2021 Jul 5;220(7). pii: 212016. doi: 10.1083/jcb.202005173. PubMed |
| BRD4 PROTAC degrader ARV-825 inhibits T-cell acute lymphoblastic leukemia by targeting 'Undruggable' Myc-pathway genes. Wu S, Jiang Y, Hong Y, Chu X, Zhang Z, Tao Y, Fan Z, Bai Z, Li X, Chen Y, Li Z, Ding X, Lv H, Du X, Lim SL, Zhang Y, Huang S, Lu J, Pan J, Hu S. Cancer Cell Int. 2021 Apr 22;21(1):230. doi: 10.1186/s12935-021-01908-w. PubMed |
| BRCA1 degradation in response to mitochondrial damage in breast cancer cells. Miyahara K, Takano N, Yamada Y, Kazama H, Tokuhisa M, Hino H, Fujita K, Barroga E, Hiramoto M, Handa H, Kuroda M, Ishikawa T, Miyazawa K. Sci Rep. 2021 Apr 22;11(1):8735. doi: 10.1038/s41598-021-87698-7. PubMed |
Co-regulation and function of FOXM1/RHNO1 bidirectional genes in cancer.
Barger CJ, Chee L, Albahrani M, Munoz-Trujillo C, Boghean L, Branick C, Odunsi K, Drapkin R, Zou L, Karpf AR.
Elife. 2021 Apr 23;10. pii: 55070. doi: 10.7554/eLife.55070.
PubMed
Associated Plasmids |
| CRISPR-based genome editing in primary human pancreatic islet cells. Bevacqua RJ, Dai X, Lam JY, Gu X, Friedlander MSH, Tellez K, Miguel-Escalada I, Bonas-Guarch S, Atla G, Zhao W, Kim SH, Dominguez AA, Qi LS, Ferrer J, MacDonald PE, Kim SK. Nat Commun. 2021 Apr 23;12(1):2397. doi: 10.1038/s41467-021-22651-w. PubMed |
| OTUD1 Activates Caspase-Independent and Caspase-Dependent Apoptosis by Promoting AIF Nuclear Translocation and MCL1 Degradation. Luo Q, Wu X, Zhao P, Nan Y, Chang W, Zhu X, Su D, Liu Z. Adv Sci (Weinh). 2021 Feb 8;8(8):2002874. doi: 10.1002/advs.202002874. eCollection 2021 Apr. PubMed |
| Pooled CRISPR-activation screening coupled with single-cell RNA-seq in mouse embryonic stem cells. Alda-Catalinas C, Eckersley-Maslin MA, Reik W. STAR Protoc. 2021 Apr 9;2(2):100426. doi: 10.1016/j.xpro.2021.100426. eCollection 2021 Jun 18. PubMed |
| Caspase-9 acts as a regulator of necroptotic cell death. Molnar T, Pallagi P, Tel B, Kiraly R, Csoma E, Jenei V, Varga Z, Gogolak P, Odile Hueber A, Mate Z, Erdelyi F, Szabo G, Pettko-Szandtner A, Bacsi A, Virag L, Maleth J, Koncz G. FEBS J. 2021 Apr 25. doi: 10.1111/febs.15898. PubMed |
| HIV-1 uncoating by release of viral cDNA from capsid-like structures in the nucleus of infected cells. Muller TG, Zila V, Peters K, Schifferdecker S, Stanic M, Lucic B, Laketa V, Lusic M, Muller B, Krausslich HG. Elife. 2021 Apr 27;10. pii: 64776. doi: 10.7554/eLife.64776. PubMed |
| Colonic epithelial adaptation to EGFR-independent growth induces chromosomal instability and is accelerated by prior injury. Chen T, Zeineldin M, Johnson BA, Dong Y, Narkar A, Li T, Zhu J, Li R, Larman TC. Neoplasia. 2021 May;23(5):488-501. doi: 10.1016/j.neo.2021.03.010. Epub 2021 Apr 24. PubMed |
| PTEN is a predictive biomarker of trastuzumab resistance and prognostic factor in HER2-overexpressing gastroesophageal adenocarcinoma. Yokoyama D, Hisamori S, Deguchi Y, Nishigori T, Okabe H, Kanaya S, Manaka D, Kadokawa Y, Hata H, Minamiguchi S, Tsunoda S, Obama K, Sakai Y. Sci Rep. 2021 Apr 27;11(1):9013. doi: 10.1038/s41598-021-88331-3. PubMed |
| Inhibition of mitochondrial translation suppresses glioblastoma stem cell growth. Sighel D, Notarangelo M, Aibara S, Re A, Ricci G, Guida M, Soldano A, Adami V, Ambrosini C, Broso F, Rosatti EF, Longhi S, Buccarelli M, D'Alessandris QG, Giannetti S, Pacioni S, Ricci-Vitiani L, Rorbach J, Pallini R, Roulland S, Amunts A, Mancini I, Modelska A, Quattrone A. Cell Rep. 2021 Apr 27;35(4):109024. doi: 10.1016/j.celrep.2021.109024. PubMed |
| PDZD8-mediated lipid transfer at contacts between the ER and late endosomes/lysosomes is required for neurite outgrowth. Gao Y, Xiong J, Chu QZ, Ji WK. J Cell Sci. 2022 Mar 1;135(5). pii: 256568. doi: 10.1242/jcs.255026. Epub 2021 Apr 20. PubMed |
| Caspase inhibition prolongs inflammation by promoting a signaling complex with activated RIPK1. Huang X, Tan S, Li Y, Cao S, Li X, Pan H, Shan B, Qian L, Yuan J. J Cell Biol. 2021 Jun 7;220(6). pii: 212035. doi: 10.1083/jcb.202007127. PubMed |
| Role of Decorin in Posterior Capsule Opacification and Eye Lens Development. Shibata S, Shibata N, Ohtsuka S, Yoshitomi Y, Kiyokawa E, Yonekura H, Singh DP, Sasaki H, Kubo E. Cells. 2021 Apr 9;10(4). pii: cells10040863. doi: 10.3390/cells10040863. PubMed |
| Selection, Expansion, and Unique Pretreatment of Allogeneic Human Natural Killer Cells with Anti-CD38 Monoclonal Antibody for Efficient Multiple Myeloma Treatment. Motais B, Charvatova S, Walek Z, Hrdinka M, Smolarczyk R, Cichon T, Czapla J, Giebel S, Simicek M, Jelinek T, Sevcikova T, Sobotka J, Koristek Z, Hajek R, Bago JR. Cells. 2021 Apr 21;10(5). pii: cells10050967. doi: 10.3390/cells10050967. PubMed |
| hTERT Downregulation Attenuates Resistance to DOX, Impairs FAK-Mediated Adhesion, and Leads to Autophagy Induction in Breast Cancer Cells. Romaniuk-Drapala A, Toton E, Konieczna N, Machnik M, Barczak W, Kowal D, Kopczynski P, Kaczmarek M, Rubis B. Cells. 2021 Apr 10;10(4). pii: cells10040867. doi: 10.3390/cells10040867. PubMed |
| Combination of Talazoparib and Palbociclib as a Potent Treatment Strategy in Bladder Cancer. Klein FG, Granier C, Zhao Y, Pan Q, Tong Z, Gschwend JE, Holm PS, Nawroth R. J Pers Med. 2021 Apr 24;11(5). pii: jpm11050340. doi: 10.3390/jpm11050340. PubMed |
Profiling the genetic determinants of chromatin accessibility with scalable single-cell CRISPR screens.
Liscovitch-Brauer N, Montalbano A, Deng J, Mendez-Mancilla A, Wessels HH, Moss NG, Kung CY, Sookdeo A, Guo X, Geller E, Jaini S, Smibert P, Sanjana NE.
Nat Biotechnol. 2021 Apr 29. pii: 10.1038/s41587-021-00902-x. doi: 10.1038/s41587-021-00902-x.
PubMed
Associated Plasmids |
| Functional landscape of SARS-CoV-2 cellular restriction. Martin-Sancho L, Lewinski MK, Pache L, Stoneham CA, Yin X, Becker ME, Pratt D, Churas C, Rosenthal SB, Liu S, Weston S, De Jesus PD, O'Neill AM, Gounder AP, Nguyen C, Pu Y, Curry HM, Oom AL, Miorin L, Rodriguez-Frandsen A, Zheng F, Wu C, Xiong Y, Urbanowski M, Shaw ML, Chang MW, Benner C, Hope TJ, Frieman MB, Garcia-Sastre A, Ideker T, Hultquist JF, Guatelli J, Chanda SK. Mol Cell. 2021 Jun 17;81(12):2656-2668.e8. doi: 10.1016/j.molcel.2021.04.008. Epub 2021 Apr 13. PubMed |
| Cut-like homeobox 1 (CUX1) tumor suppressor gene haploinsufficiency induces apoptosis evasion to sustain myeloid leukemia. Supper E, Rudat S, Iyer V, Droop A, Wong K, Spinella JF, Thomas P, Sauvageau G, Adams DJ, Wong CC. Nat Commun. 2021 Apr 30;12(1):2482. doi: 10.1038/s41467-021-22750-8. PubMed |
| Multiple interactions of the oncoprotein transcription factor MYC with the SWI/SNF chromatin remodeler. Woodley CM, Romer AS, Wang J, Guarnaccia AD, Elion DL, Maxwell JN, Guerrazzi K, McCann TS, Popay TM, Matlock BK, Flaherty DK, Lorey SL, Liu Q, Tansey WP, Weissmiller AM. Oncogene. 2021 May;40(20):3593-3609. doi: 10.1038/s41388-021-01804-7. Epub 2021 Apr 30. PubMed |
| HIF1alpha-dependent induction of the mitochondrial chaperone TRAP1 regulates bioenergetic adaptations to hypoxia. Laquatra C, Sanchez-Martin C, Dinarello A, Cannino G, Minervini G, Moroni E, Schiavone M, Tosatto S, Argenton F, Colombo G, Bernardi P, Masgras I, Rasola A. Cell Death Dis. 2021 May 1;12(5):434. doi: 10.1038/s41419-021-03716-6. PubMed |
| Quantitative proteomic analysis of extracellular vesicle subgroups isolated by an optimized method combining polymer-based precipitation and size exclusion chromatography. Martinez-Greene JA, Hernandez-Ortega K, Quiroz-Baez R, Resendis-Antonio O, Pichardo-Casas I, Sinclair DA, Budnik B, Hidalgo-Miranda A, Uribe-Querol E, Ramos-Godinez MDP, Martinez-Martinez E. J Extracell Vesicles. 2021 Apr;10(6):e12087. doi: 10.1002/jev2.12087. Epub 2021 Apr 27. PubMed |
| Host-Dependent Phenotypic Resistance to EGFR Tyrosine Kinase Inhibitors. Haga Y, Marrocco I, Noronha A, Uribe ML, Nataraj NB, Sekar A, Drago-Garcia D, Borgoni S, Lindzen M, Giri S, Wiemann S, Tsutsumi Y, Yarden Y. Cancer Res. 2021 Jul 15;81(14):3862-3875. doi: 10.1158/0008-5472.CAN-20-3555. Epub 2021 May 3. PubMed |
| G3BP1 Inhibition Alleviates Intracellular Nucleic Acid-Induced Autoimmune Responses. Cai H, Liu X, Zhang F, Han QY, Liu ZS, Xue W, Guo ZL, Zhao JM, Sun LM, Wang N, Mao J, He K, Xia T, Chen Y, Chen L, Li AL, Zhou T, Zhang XM, Li WH, Li T. J Immunol. 2021 May 15;206(10):2453-2467. doi: 10.4049/jimmunol.2001111. Epub 2021 May 3. PubMed |
| Delineating the heterogeneity of matrix-directed differentiation toward soft and stiff tissue lineages via single-cell profiling. Brielle S, Bavli D, Motzik A, Kan-Tor Y, Sun X, Kozulin C, Avni B, Ram O, Buxboim A. Proc Natl Acad Sci U S A. 2021 May 11;118(19). pii: 2016322118. doi: 10.1073/pnas.2016322118. PubMed |
| The Zinc Finger Antiviral Protein ZAP Restricts Human Cytomegalovirus and Selectively Binds and Destabilizes Viral UL4/UL5 Transcripts. Gonzalez-Perez AC, Stempel M, Wyler E, Urban C, Piras A, Hennig T, Ganskih S, Wei Y, Heim A, Landthaler M, Pichlmair A, Dolken L, Munschauer M, Erhard F, Brinkmann MM. mBio. 2021 May 4;12(3). pii: mBio.02683-20. doi: 10.1128/mBio.02683-20. PubMed |
| Structure of the full-length human Pannexin1 channel and insights into its role in pyroptosis. Zhang S, Yuan B, Lam JH, Zhou J, Zhou X, Ramos-Mandujano G, Tian X, Liu Y, Han R, Li Y, Gao X, Li M, Yang M. Cell Discov. 2021 May 4;7(1):30. doi: 10.1038/s41421-021-00259-0. PubMed |
| SAM homeostasis is regulated by CFIm-mediated splicing of MAT2A. Scarborough AM, Flaherty JN, Hunter OV, Liu K, Kumar A, Xing C, Tu BP, Conrad NK. Elife. 2021 May 5;10. pii: 64930. doi: 10.7554/eLife.64930. PubMed |
| High-Level Production of Recombinant Eukaryotic Proteins from Mammalian Cells Using Lentivirus. Behiels E, Elegheert J. Methods Mol Biol. 2021;2305:83-104. doi: 10.1007/978-1-0716-1406-8_4. PubMed |
| Development of a VRC01-class germline targeting immunogen derived from anti-idiotypic antibodies. Seydoux E, Wan YH, Feng J, Wall A, Aljedani S, Homad LJ, MacCamy AJ, Weidle C, Gray MD, Brumage L, Taylor JJ, Pancera M, Stamatatos L, McGuire AT. Cell Rep. 2021 May 4;35(5):109084. doi: 10.1016/j.celrep.2021.109084. PubMed |
| Sarcomere function activates a p53-dependent DNA damage response that promotes polyploidization and limits in vivo cell engraftment. Pettinato AM, Yoo D, VanOudenhove J, Chen YS, Cohn R, Ladha FA, Yang X, Thakar K, Romano R, Legere N, Meredith E, Robson P, Regnier M, Cotney JL, Murry CE, Hinson JT. Cell Rep. 2021 May 4;35(5):109088. doi: 10.1016/j.celrep.2021.109088. PubMed |
Photoactivated voltage imaging in tissue with an archaerhodopsin-derived reporter.
Chien MP, Brinks D, Testa-Silva G, Tian H, Phil Brooks F 3rd, Adam Y, Bloxham W, Gmeiner B, Kheifets S, Cohen AE.
Sci Adv. 2021 May 5;7(19). pii: 7/19/eabe3216. doi: 10.1126/sciadv.abe3216. Print 2021 May.
PubMed
Associated Plasmids |
| Cohesin-protein Shugoshin-1 controls cardiac automaticity via HCN4 pacemaker channel. Liu D, Song AT, Qi X, van Vliet PP, Xiao J, Xiong F, Andelfinger G, Nattel S. Nat Commun. 2021 May 5;12(1):2551. doi: 10.1038/s41467-021-22737-5. PubMed |
| Minimized combinatorial CRISPR screens identify genetic interactions in autophagy. Diehl V, Wegner M, Grumati P, Husnjak K, Schaubeck S, Gubas A, Shah VJ, Polat IH, Langschied F, Prieto-Garcia C, Muller K, Kalousi A, Ebersberger I, Brandts CH, Dikic I, Kaulich M. Nucleic Acids Res. 2021 Jun 4;49(10):5684-5704. doi: 10.1093/nar/gkab309. PubMed |
| MyD88 oligomer size functions as a physical threshold to trigger IL1R Myddosome signaling. Deliz-Aguirre R, Cao F, Gerpott FHU, Auevechanichkul N, Chupanova M, Mun Y, Ziska E, Taylor MJ. J Cell Biol. 2021 Jul 5;220(7). pii: 212080. doi: 10.1083/jcb.202012071. Epub 2021 May 6. PubMed |
| Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains. Piette BL, Alerasool N, Lin ZY, Lacoste J, Lam MHY, Qian WW, Tran S, Larsen B, Campos E, Peng J, Gingras AC, Taipale M. Mol Cell. 2021 Jun 17;81(12):2549-2565.e8. doi: 10.1016/j.molcel.2021.04.012. Epub 2021 May 5. PubMed |
| HOTAIR lncRNA promotes epithelial-mesenchymal transition by redistributing LSD1 at regulatory chromatin regions. Jarroux J, Foretek D, Bertrand C, Gabriel M, Szachnowski U, Saci Z, Guo S, Londono-Vallejo A, Pinskaya M, Morillon A. EMBO Rep. 2021 Jul 5;22(7):e50193. doi: 10.15252/embr.202050193. Epub 2021 May 6. PubMed |
| Alternative glycosylation controls endoplasmic reticulum dynamics and tubular extension in mammalian cells. Kerselidou D, Dohai BS, Nelson DR, Daakour S, De Cock N, Hassoun ZAO, Kim DK, Olivet J, El Assal DC, Jaiswal A, Alzahmi A, Saha D, Pain C, Matthijssens F, Lemaitre P, Herfs M, Chapuis J, Ghesquiere B, Vertommen D, Kriechbaumer V, Knoops K, Lopez-Iglesias C, van Zandvoort M, Lambert JC, Hanson J, Desmet C, Thiry M, Lauersen KJ, Vidal M, Van Vlierberghe P, Dequiedt F, Salehi-Ashtiani K, Twizere JC. Sci Adv. 2021 May 7;7(19). pii: 7/19/eabe8349. doi: 10.1126/sciadv.abe8349. Print 2021 May. PubMed |
| Membrane protein regulators of melanoma pulmonary colonisation identified using a CRISPRa screen and spontaneous metastasis assay in mice. van der Weyden L, Offord V, Turner G, Swiatkowska A, Speak AO, Adams DJ. G3 (Bethesda). 2021 May 7. pii: 6272227. doi: 10.1093/g3journal/jkab157. PubMed |
| Marker-free quantification of repair pathway utilization at Cas9-induced double-strand breaks. Feng W, Simpson DA, Cho JE, Carvajal-Garcia J, Smith CM, Headley KM, Hathaway N, Ramsden DA, Gupta GP. Nucleic Acids Res. 2021 May 21;49(9):5095-5105. doi: 10.1093/nar/gkab299. PubMed |
| Coiled-Coil Domain-Containing 68 Downregulation Promotes Colorectal Cancer Cell Growth by Inhibiting ITCH-Mediated CDK4 Degradation. Wang C, Li H, Wu L, Jiao X, Jin Z, Zhu Y, Fang Z, Zhang X, Huang H, Zhao L. Front Oncol. 2021 Apr 22;11:668743. doi: 10.3389/fonc.2021.668743. eCollection 2021. PubMed |
| Effects of Amyloid Precursor Protein Overexpression on NF-kappaB, Rho-GTPase and Pro-Apoptosis Bcl-2 Pathways in Neuronal Cells. Chan HH, Leong YQ, Voon SM, Pan ML, Leong CO, Lim CL, Koh RY. Rep Biochem Mol Biol. 2021 Jan;9(4):417-425. doi: 10.52547/rbmb.9.4.417. PubMed |
Longitudinal proteomic analysis of severe COVID-19 reveals survival-associated signatures, tissue-specific cell death, and cell-cell interactions.
Filbin MR, Mehta A, Schneider AM, Kays KR, Guess JR, Gentili M, Fenyves BG, Charland NC, Gonye ALK, Gushterova I, Khanna HK, LaSalle TJ, Lavin-Parsons KM, Lilley BM, Lodenstein CL, Manakongtreecheep K, Margolin JD, McKaig BN, Rojas-Lopez M, Russo BC, Sharma N, Tantivit J, Thomas MF, Gerszten RE, Heimberg GS, Hoover PJ, Lieb DJ, Lin B, Ngo D, Pelka K, Reyes M, Smillie CS, Waghray A, Wood TE, Zajac AS, Jennings LL, Grundberg I, Bhattacharyya RP, Parry BA, Villani AC, Sade-Feldman M, Hacohen N, Goldberg MB.
Cell Rep Med. 2021 May 18;2(5):100287. doi: 10.1016/j.xcrm.2021.100287. Epub 2021 May 3.
PubMed
Associated Plasmids |
| Smac mimetics and TRAIL cooperate to induce MLKL-dependent necroptosis in Burkitt's lymphoma cell lines. Koch A, Jeiler B, Roedig J, van Wijk SJL, Dolgikh N, Fulda S. Neoplasia. 2021 May;23(5):539-550. doi: 10.1016/j.neo.2021.03.003. Epub 2021 May 7. PubMed |
| Cell-surface SLC nucleoside transporters and purine levels modulate BRD4-dependent chromatin states. Li KC, Girardi E, Kartnig F, Grosche S, Pemovska T, Bigenzahn JW, Goldmann U, Sedlyarov V, Bensimon A, Schick S, Lin JG, Gurtl B, Reil D, Klavins K, Kubicek S, Sdelci S, Superti-Furga G. Nat Metab. 2021 May;3(5):651-664. doi: 10.1038/s42255-021-00386-8. Epub 2021 May 10. PubMed |
| A novel thermostable beetle luciferase based cytotoxicity assay. Choi S, Matta H, Gopalakrishnan R, Natarajan V, Gong S, Jeronimo A, Kuo WY, Bravo B, Chaudhary PM. Sci Rep. 2021 May 11;11(1):10002. doi: 10.1038/s41598-021-89404-z. PubMed |
| Depletion of kinesin motor KIF20A to target cell fate control suppresses medulloblastoma tumour growth. Qiu R, Wu J, Gudenas B, Northcott PA, Wechsler-Reya RJ, Lu Q. Commun Biol. 2021 May 11;4(1):552. doi: 10.1038/s42003-021-02075-4. PubMed |
| Delete_A Facile Method to Engineer Mutant Kras Alleles in an Isogenic Cell Background. Budagyan K, Chernoff J. Methods Mol Biol. 2021;2262:323-334. doi: 10.1007/978-1-0716-1190-6_20. PubMed |
| The inhibitory receptor TIM-3 limits activation of the cGAS-STING pathway in intra-tumoral dendritic cells by suppressing extracellular DNA uptake. de Mingo Pulido A, Hanggi K, Celias DP, Gardner A, Li J, Batista-Bittencourt B, Mohamed E, Trillo-Tinoco J, Osunmakinde O, Pena R, Onimus A, Kaisho T, Kaufmann J, McEachern K, Soliman H, Luca VC, Rodriguez PC, Yu X, Ruffell B. Immunity. 2021 Jun 8;54(6):1154-1167.e7. doi: 10.1016/j.immuni.2021.04.019. Epub 2021 May 11. PubMed |
| RIPK1 is a negative mediator in Aquaporin 1-driven triple-negative breast carcinoma progression and metastasis. Yin Z, Chen W, Yin J, Sun J, Xie Q, Wu M, Zeng F, Ren H. NPJ Breast Cancer. 2021 May 12;7(1):53. doi: 10.1038/s41523-021-00261-5. PubMed |
| Structural basis for broad coronavirus neutralization. Sauer MM, Tortorici MA, Park YJ, Walls AC, Homad L, Acton OJ, Bowen JE, Wang C, Xiong X, de van der Schueren W, Quispe J, Hoffstrom BG, Bosch BJ, McGuire AT, Veesler D. Nat Struct Mol Biol. 2021 Jun;28(6):478-486. doi: 10.1038/s41594-021-00596-4. Epub 2021 May 12. PubMed |
| SOX9-induced Generation of Functional Astrocytes Supporting Neuronal Maturation in an All-human System. Neyrinck K, Van Den Daele J, Vervliet T, De Smedt J, Wierda K, Nijs M, Vanbokhoven T, D'hondt A, Planque M, Fendt SM, Shih PY, Seibt F, Almenar JP, Kreir M, Kumar D, Broccoli V, Bultynck G, Ebneth A, Cabrera-Socorro A, Verfaillie C. Stem Cell Rev Rep. 2021 May 12. pii: 10.1007/s12015-021-10179-x. doi: 10.1007/s12015-021-10179-x. PubMed |
| Hyperbaric oxygen promotes not only glioblastoma proliferation but also chemosensitization by inhibiting HIF1alpha/HIF2alpha-Sox2. Wang P, Gong S, Pan J, Wang J, Zou D, Xiong S, Zhao L, Yan Q, Deng Y, Wu N, Liao B. Cell Death Discov. 2021 May 13;7(1):103. doi: 10.1038/s41420-021-00486-0. PubMed |
| Differentiation-related zinc finger protein 750 suppresses cell growth in esophageal squamous cell carcinoma. Ana Choi SS, Ko JM, Yu VZ, Ning L, Lung ML. Oncol Lett. 2021 Jul;22(1):513. doi: 10.3892/ol.2021.12774. Epub 2021 May 5. PubMed |
| Loss of the WNT9a ligand aggravates the rheumatoid arthritis-like symptoms in hTNF transgenic mice. Teufel S, Kockemann P, Fabritius C, Wolff LI, Bertrand J, Pap T, Hartmann C. Cell Death Dis. 2021 May 15;12(5):494. doi: 10.1038/s41419-021-03786-6. PubMed |
| G-protein coupled receptor 35 (GPR35) regulates the colonic epithelial cell response to enterotoxigenic Bacteroides fragilis. Boleij A, Fathi P, Dalton W, Park B, Wu X, Huso D, Allen J, Besharati S, Anders RA, Housseau F, Mackenzie AE, Jenkins L, Milligan G, Wu S, Sears CL. Commun Biol. 2021 May 14;4(1):585. doi: 10.1038/s42003-021-02014-3. PubMed |
| Dihydrotanshinone Inhibits Hepatocellular Carcinoma by Suppressing the JAK2/STAT3 Pathway. Hu X, Jiao F, Zhang L, Jiang Y. Front Pharmacol. 2021 Apr 29;12:654986. doi: 10.3389/fphar.2021.654986. eCollection 2021. PubMed |
| NF-kappaB c-Rel Is Dispensable for the Development but Is Required for the Cytotoxic Function of NK Cells. Vicioso Y, Wong DP, Roy NK, Das N, Zhang K, Ramakrishnan P, Parameswaran R. Front Immunol. 2021 Apr 29;12:652786. doi: 10.3389/fimmu.2021.652786. eCollection 2021. PubMed |
| KAT6A, a novel regulator of beta-catenin, promotes tumorigenicity and chemoresistance in ovarian cancer by acetylating COP1. Liu W, Zhan Z, Zhang M, Sun B, Shi Q, Luo F, Zhang M, Zhang W, Hou Y, Xiao X, Li Y, Feng H. Theranostics. 2021 Apr 15;11(13):6278-6292. doi: 10.7150/thno.57455. eCollection 2021. PubMed |
| Impairment of the ER/mitochondria compartment in human cardiomyocytes with PLN p.Arg14del mutation. Cuello F, Knaust AE, Saleem U, Loos M, Raabe J, Mosqueira D, Laufer S, Schweizer M, van der Kraak P, Flenner F, Ulmer BM, Braren I, Yin X, Theofilatos K, Ruiz-Orera J, Patone G, Klampe B, Schulze T, Piasecki A, Pinto Y, Vink A, Hubner N, Harding S, Mayr M, Denning C, Eschenhagen T, Hansen A. EMBO Mol Med. 2021 Jun 7;13(6):e13074. doi: 10.15252/emmm.202013074. Epub 2021 May 16. PubMed |
| mTOR controls endoplasmic reticulum-Golgi apparatus trafficking of VSVg in specific cell types. Koscielny A, Liszewska E, Machnicka K, Wezyk M, Kotulska K, Jaworski J. Cell Mol Biol Lett. 2021 May 18;26(1):18. doi: 10.1186/s11658-021-00262-z. PubMed |
| A virulent Bacillus cereus strain from deep-sea cold seep induces pyroptosis in a manner that involves NLRP3 inflammasome, JNK pathway, and lysosomal rupture. Zhao Y, Jiang S, Zhang J, Guan XL, Sun BG, Sun L. Virulence. 2021 Dec;12(1):1362-1376. doi: 10.1080/21505594.2021.1926649. PubMed |
| Inhibitory affinity modulation of FcgammaRIIA ligand binding by glycosphingolipids by inside-out signaling. Okubo K, Brenner MD, Cullere X, Saggu G, Patchen ML, Bose N, Mihori S, Yuan Z, Lowell CA, Zhu C, Mayadas TN. Cell Rep. 2021 May 18;35(7):109142. doi: 10.1016/j.celrep.2021.109142. PubMed |
| Cargo receptor-assisted endoplasmic reticulum export of pathogenic alpha1-antitrypsin polymers. Ordonez A, Harding HP, Marciniak SJ, Ron D. Cell Rep. 2021 May 18;35(7):109144. doi: 10.1016/j.celrep.2021.109144. PubMed |
| The metabolite alpha-KG induces GSDMC-dependent pyroptosis through death receptor 6-activated caspase-8. Zhang JY, Zhou B, Sun RY, Ai YL, Cheng K, Li FN, Wang BR, Liu FJ, Jiang ZH, Wang WJ, Zhou D, Chen HZ, Wu Q. Cell Res. 2021 Sep;31(9):980-997. doi: 10.1038/s41422-021-00506-9. Epub 2021 May 19. PubMed |
| The promiscuous binding pocket of SLC35A1 ensures redundant transport of CDP-ribitol to the Golgi. Ury B, Potelle S, Caligiore F, Whorton MR, Bommer GT. J Biol Chem. 2021 Jan-Jun;296:100789. doi: 10.1016/j.jbc.2021.100789. Epub 2021 May 18. PubMed |
| UBX Domain Protein 6 Positively Regulates JAK-STAT1/2 Signaling. Ketkar H, Harrison AG, Graziano VR, Geng T, Yang L, Vella AT, Wang P. J Immunol. 2021 Jun 1;206(11):2682-2691. doi: 10.4049/jimmunol.1901337. Epub 2021 May 21. PubMed |
| Integrin-dependent migratory switches regulate the translocation of Toxoplasma-infected dendritic cells across brain endothelial monolayers. Ross EC, Ten Hoeve AL, Barragan A. Cell Mol Life Sci. 2021 Jun;78(12):5197-5212. doi: 10.1007/s00018-021-03858-y. Epub 2021 May 22. PubMed |
| Avadomide induces degradation of ZMYM2 fusion oncoproteins in hematologic malignancies. Renneville A, Gasser JA, Grinshpun DE, Jean Beltran PM, Udeshi ND, Matyskiela ME, Clayton T, McConkey M, Viswanathan K, Tepper A, Guirguis AA, Sellar RS, Cotteret S, Marzac C, Saada V, De Botton S, Kiladjian JJ, Cayuela JM, Rolfe M, Chamberlain PP, Carr SA, Ebert BL. Blood Cancer Discov. 2021 May;2(3):250-265. doi: 10.1158/2643-3230.bcd-20-0105. Epub 2021 Mar 10. PubMed |
| Genetic manipulation of adhesion GPCR CD97/ADGRE5 modulates invasion in patient-derived glioma stem cells. Eichberg DG, Slepak TI, Pascoini AL, Komotar RJ, Ivan ME. J Neurooncol. 2021 Jul;153(3):383-391. doi: 10.1007/s11060-021-03778-8. Epub 2021 May 24. PubMed |
| ILF3 Is a Negative Transcriptional Regulator of Innate Immune Responses and Myeloid Dendritic Cell Maturation. Nazitto R, Amon LM, Mast FD, Aitchison JD, Aderem A, Johnson JS, Diercks AH. J Immunol. 2021 May 24. pii: jimmunol.2001235. doi: 10.4049/jimmunol.2001235. PubMed |
| Platelet-Derived Growth Factor Receptor-alpha Subunit Targeting Suppresses Metastasis in Advanced Thyroid Cancer In Vitro and In Vivo. Lin CL, Tsai ML, Chen YH, Liu WN, Lin CY, Hsu KW, Huang CY, Chang YJ, Wei PL, Chen SH, Huang LC, Lee CH. Biomol Ther (Seoul). 2021 Sep 1;29(5):551-561. doi: 10.4062/biomolther.2020.205. PubMed |
| Cul3 regulates cytoskeleton protein homeostasis and cell migration during a critical window of brain development. Morandell J, Schwarz LA, Basilico B, Tasciyan S, Dimchev G, Nicolas A, Sommer C, Kreuzinger C, Dotter CP, Knaus LS, Dobler Z, Cacci E, Schur FKM, Danzl JG, Novarino G. Nat Commun. 2021 May 24;12(1):3058. doi: 10.1038/s41467-021-23123-x. PubMed |
MPP8 is essential for sustaining self-renewal of ground-state pluripotent stem cells.
Muller I, Moroni AS, Shlyueva D, Sahadevan S, Schoof EM, Radzisheuskaya A, Hojfeldt JW, Tatar T, Koche RP, Huang C, Helin K.
Nat Commun. 2021 May 24;12(1):3034. doi: 10.1038/s41467-021-23308-4.
PubMed
Associated Plasmids |
| In vivo genome-wide CRISPR screen reveals breast cancer vulnerabilities and synergistic mTOR/Hippo targeted combination therapy. Dai M, Yan G, Wang N, Daliah G, Edick AM, Poulet S, Boudreault J, Ali S, Burgos SA, Lebrun JJ. Nat Commun. 2021 May 24;12(1):3055. doi: 10.1038/s41467-021-23316-4. PubMed |
| CD13 is a critical regulator of cell-cell fusion in osteoclastogenesis. Ghosh M, Kelava T, Madunic IV, Kalajzic I, Shapiro LH. Sci Rep. 2021 May 24;11(1):10736. doi: 10.1038/s41598-021-90271-x. PubMed |
| Shear-stress sensing by PIEZO1 regulates tendon stiffness in rodents and influences jumping performance in humans. Passini FS, Jaeger PK, Saab AS, Hanlon S, Chittim NA, Arlt MJ, Ferrari KD, Haenni D, Caprara S, Bollhalder M, Niederost B, Horvath AN, Gotschi T, Ma S, Passini-Tall B, Fucentese SF, Blache U, Silvan U, Weber B, Silbernagel KG, Snedeker JG. Nat Biomed Eng. 2021 Dec;5(12):1457-1471. doi: 10.1038/s41551-021-00716-x. Epub 2021 May 24. PubMed |
| Mitohormesis reprogrammes macrophage metabolism to enforce tolerance. Timblin GA, Tharp KM, Ford B, Winchester JM, Wang J, Zhu S, Khan RI, Louie SK, Iavarone AT, Ten Hoeve J, Nomura DK, Stahl A, Saijo K. Nat Metab. 2021 May;3(5):618-635. doi: 10.1038/s42255-021-00392-w. Epub 2021 May 20. PubMed |
| SYNCRIP facilitates porcine parvovirus viral DNA replication through the alternative splicing of NS1 mRNA to promote NS2 mRNA formation. Chen S, Miao B, Chen N, Chen C, Shao T, Zhang X, Chang L, Zhang X, Du Q, Huang Y, Tong D. Vet Res. 2021 May 25;52(1):73. doi: 10.1186/s13567-021-00938-6. PubMed |
| FOXM1 repression increases mitotic death upon antimitotic chemotherapy through BMF upregulation. Vaz S, Ferreira FJ, Macedo JC, Leor G, Ben-David U, Bessa J, Logarinho E. Cell Death Dis. 2021 May 25;12(6):542. doi: 10.1038/s41419-021-03822-5. PubMed |
| Phenotypic plasticity underlies local invasion and distant metastasis in colon cancer. Sacchetti A, Teeuwssen M, Verhagen M, Joosten R, Xu T, Stabile R, van der Steen B, Watson MM, Gusinac A, Kim WK, Ubink I, Van de Werken HJ, Fumagalli A, Paauwe M, Van Rheenen J, Sansom OJ, Kranenburg O, Fodde R. Elife. 2021 May 26;10. pii: 61461. doi: 10.7554/eLife.61461. PubMed |
| ELAVL1 primarily couples mRNA stability with the 3' UTRs of interferon-stimulated genes. Rothamel K, Arcos S, Kim B, Reasoner C, Lisy S, Mukherjee N, Ascano M. Cell Rep. 2021 May 25;35(8):109178. doi: 10.1016/j.celrep.2021.109178. PubMed |
| The autophagy protein Becn1 improves insulin sensitivity by promoting adiponectin secretion via exocyst binding. Kuramoto K, Kim YJ, Hong JH, He C. Cell Rep. 2021 May 25;35(8):109184. doi: 10.1016/j.celrep.2021.109184. PubMed |
| AMPKalpha loss promotes KRAS-mediated lung tumorigenesis. La Montagna M, Shi L, Magee P, Sahoo S, Fassan M, Garofalo M. Cell Death Differ. 2021 Sep;28(9):2673-2689. doi: 10.1038/s41418-021-00777-0. Epub 2021 May 26. PubMed |
| Optimal Ratio of Wnt3a Expression in Human Mesenchymal Stem Cells Promotes Axonal Regeneration in Spinal Cord Injured Rat Model. Yoon HH, Lee HJ, Min J, Kim JH, Park JH, Kim JH, Kim SW, Lee H, Jeon SR. J Korean Neurosurg Soc. 2021 Sep;64(5):705-715. doi: 10.3340/jkns.2021.0003. Epub 2021 May 28. PubMed |
| SARS-CoV-2 exacerbates proinflammatory responses in myeloid cells through C-type lectin receptors and Tweety family member 2. Lu Q, Liu J, Zhao S, Gomez Castro MF, Laurent-Rolle M, Dong J, Ran X, Damani-Yokota P, Tang H, Karakousi T, Son J, Kaczmarek ME, Zhang Z, Yeung ST, McCune BT, Chen RE, Tang F, Ren X, Chen X, Hsu JCC, Teplova M, Huang B, Deng H, Long Z, Mudianto T, Jin S, Lin P, Du J, Zang R, Su TT, Herrera A, Zhou M, Yan R, Cui J, Zhu J, Zhou Q, Wang T, Ma J, Koralov SB, Zhang Z, Aifantis I, Segal LN, Diamond MS, Khanna KM, Stapleford KA, Cresswell P, Liu Y, Ding S, Xie Q, Wang J. Immunity. 2021 Jun 8;54(6):1304-1319.e9. doi: 10.1016/j.immuni.2021.05.006. Epub 2021 May 9. PubMed |
| MicroRNA-30c delivered by bone marrow-mesenchymal stem cells induced apoptosis and diminished cell invasion in U-251 glioblastoma cell line. Mahjoor M, Afkhami H, Mollaei M, Nasr A, Shahriary S, Khorrami S. Life Sci. 2021 Aug 15;279:119643. doi: 10.1016/j.lfs.2021.119643. Epub 2021 May 25. PubMed |
| Pooled CRISPR screening in pancreatic cancer cells implicates co-repressor complexes as a cause of multiple drug resistance via regulation of epithelial-to-mesenchymal transition. Ramaker RC, Hardigan AA, Gordon ER, Wright CA, Myers RM, Cooper SJ. BMC Cancer. 2021 May 29;21(1):632. doi: 10.1186/s12885-021-08388-1. PubMed |
| Histone deficiency and accelerated replication stress in T cell aging. Kim C, Jin J, Ye Z, Jadhav RR, Gustafson CE, Hu B, Cao W, Tian L, Weyand CM, Goronzy JJ. J Clin Invest. 2021 Jun 1;131(11). pii: e143632. doi: 10.1172/JCI143632. PubMed |
| Altering transcription factor binding reveals comprehensive transcriptional kinetics of a basic gene. Popp AP, Hettich J, Gebhardt JCM. Nucleic Acids Res. 2021 Jun 21;49(11):6249-6266. doi: 10.1093/nar/gkab443. PubMed |
| Inhibitory effect on SARS-CoV-2 infection of neferine by blocking Ca(2+) -dependent membrane fusion. Yang Y, Yang P, Huang C, Wu Y, Zhou Z, Wang X, Wang S. J Med Virol. 2021 Oct;93(10):5825-5832. doi: 10.1002/jmv.27117. Epub 2021 Jun 9. PubMed |
| Role of IQGAP1 in Papillomavirus-Associated Head and Neck Tumorigenesis. Wei T, Choi S, Buehler D, Lee D, Ward-Shaw E, Anderson RA, Lambert PF. Cancers (Basel). 2021 May 10;13(9). pii: cancers13092276. doi: 10.3390/cancers13092276. PubMed |
| The Lysine Methylase SMYD3 Modulates Mesendodermal Commitment during Development. Fittipaldi R, Floris P, Proserpio V, Cotelli F, Beltrame M, Caretti G. Cells. 2021 May 18;10(5). pii: cells10051233. doi: 10.3390/cells10051233. PubMed |
| Generation and Characterization of a CRISPR/Cas9-Mediated SNAP29 Knockout in Human Fibroblasts. Martens MC, Edelkamp J, Seebode C, Schafer M, Stahlke S, Krohn S, Jung O, Murua Escobar H, Emmert S, Boeckmann L. Int J Mol Sci. 2021 May 18;22(10). pii: ijms22105293. doi: 10.3390/ijms22105293. PubMed |
| IGF1-mediated HOXA13 overexpression promotes colorectal cancer metastasis through upregulating ACLY and IGF1R. Qiao C, Huang W, Chen J, Feng W, Zhang T, Wang Y, Liu D, Ji X, Xie M, Sun M, Fan D, Wu K, Xia L. Cell Death Dis. 2021 Jun 1;12(6):564. doi: 10.1038/s41419-021-03833-2. PubMed |
Targeted delivery of CRISPR-Cas9 and transgenes enables complex immune cell engineering.
Hamilton JR, Tsuchida CA, Nguyen DN, Shy BR, McGarrigle ER, Sandoval Espinoza CR, Carr D, Blaeschke F, Marson A, Doudna JA.
Cell Rep. 2021 Jun 1;35(9):109207. doi: 10.1016/j.celrep.2021.109207.
PubMed
Associated Plasmids |
| WNT5A inhibition alters the malignant peripheral nerve sheath tumor microenvironment and enhances tumor growth. Thomson CS, Pundavela J, Perrino MR, Coover RA, Choi K, Chaney KE, Rizvi TA, Largaespada DA, Ratner N. Oncogene. 2021 Jun;40(24):4229-4241. doi: 10.1038/s41388-021-01773-x. Epub 2021 Jun 2. PubMed |
| miR-590-5p targets RMND5A and promotes migration in pancreatic adenocarcinoma cell lines. Chen S, Chen Y, Wen Y, Cai W, Zhu P, Yuan W, Li Y, Fan X, Wan Y, Li F, Zhuang J, Jiang Z, Wu X, Wang Y. Oncol Lett. 2021 Jul;22(1):532. doi: 10.3892/ol.2021.12793. Epub 2021 May 17. PubMed |
| Calcium signaling mediates a biphasic mechanoadaptive response of endothelial cells to cyclic mechanical stretch. Miroshnikova YA, Manet S, Li X, Wickstrom SA, Faurobert E, Albiges-Rizo C. Mol Biol Cell. 2021 Aug 19;32(18):1724-1736. doi: 10.1091/mbc.E21-03-0106. Epub 2021 Jun 3. PubMed |
| Src-Yap1 signaling axis controls the trophectoderm and epiblast lineage differentiation in mouse embryonic stem cells. Luo J, Zou H, Li P. Stem Cell Res. 2021 Jul;54:102413. doi: 10.1016/j.scr.2021.102413. Epub 2021 May 29. PubMed |
Non-invasive and high-throughput interrogation of exon-specific isoform expression.
Truong DJ, Phlairaharn T, Esswein B, Gruber C, Tumen D, Baligacs E, Armbrust N, Vaccaro FL, Lederer EM, Beck EM, Geilenkeuser J, Goppert S, Krumwiede L, Gratz C, Raffl G, Schwarz D, Zirngibl M, Zivanic M, Beyer M, Korner JD, Santl T, Evsyukov V, Strauss T, Schwarz SC, Hoglinger GU, Heutink P, Doll S, Conrad M, Giesert F, Wurst W, Westmeyer GG.
Nat Cell Biol. 2021 Jun;23(6):652-663. doi: 10.1038/s41556-021-00678-x. Epub 2021 Jun 3.
PubMed
Associated Plasmids |
| Reprogramming an energetic AKT-PAK5 axis boosts axon energy supply and facilitates neuron survival and regeneration after injury and ischemia. Huang N, Li S, Xie Y, Han Q, Xu XM, Sheng ZH. Curr Biol. 2021 Jul 26;31(14):3098-3114.e7. doi: 10.1016/j.cub.2021.04.079. Epub 2021 Jun 3. PubMed |
| ERK signaling mediates resistance to immunomodulatory drugs in the bone marrow microenvironment. Liu J, Hideshima T, Xing L, Wang S, Zhou W, Samur MK, Sewastianik T, Ogiya D, An G, Gao S, Yang L, Ji T, Bianchi G, Wen K, Tai YT, Munshi N, Richardson P, Carrasco R, Cang Y, Anderson KC. Sci Adv. 2021 Jun 4;7(23). pii: 7/23/eabg2697. doi: 10.1126/sciadv.abg2697. Print 2021 Jun. PubMed |
| Sunitinib and Axitinib increase secretion and glycolytic activity of small extracellular vesicles in renal cell carcinoma. Lim AR, Vincent BG, Weaver AM, Rathmell WK. Cancer Gene Ther. 2022 Jun;29(6):683-696. doi: 10.1038/s41417-021-00345-1. Epub 2021 Jun 4. PubMed |
| The RNA-binding protein HuR is a novel target of Pirh2 E3 ubiquitin ligase. Daks A, Petukhov A, Fedorova O, Shuvalov O, Kizenko A, Tananykina E, Vasileva E, Semenov O, Bottrill A, Barlev N. Cell Death Dis. 2021 Jun 5;12(6):581. doi: 10.1038/s41419-021-03871-w. PubMed |
| uc.77- Downregulation Promotes Colorectal Cancer Cell Proliferation by Inhibiting FBXW8-Mediated CDK4 Protein Degradation. Zheng Z, Hong D, Zhang X, Chang Y, Sun N, Lin Z, Li H, Huang S, Zhang R, Xie Q, Huang H, Jin H. Front Oncol. 2021 May 19;11:673223. doi: 10.3389/fonc.2021.673223. eCollection 2021. PubMed |
| Protocol for genome-scale CRISPR screening in engineered lineage reporter hPSCs to study cell fate determination. Zhou Z, Ma L, Zhang X. STAR Protoc. 2021 May 20;2(2):100548. doi: 10.1016/j.xpro.2021.100548. eCollection 2021 Jun 18. PubMed |
| A phenotypically supervised single-cell analysis protocol to study within-cell-type heterogeneity of cultured mammalian cells. Chen K, Ozturk K, Liefeld T, Reich M, Mesirov JP, Carter H, Fraley SI. STAR Protoc. 2021 May 25;2(2):100561. doi: 10.1016/j.xpro.2021.100561. eCollection 2021 Jun 18. PubMed |
| Interferon regulatory factor 7 impairs cellular metabolism in aging adipose-derived stromal cells. Nodari A, Scambi I, Peroni D, Calabria E, Benati D, Mannucci S, Manfredi M, Frontini A, Visona S, Bozzato A, Sbarbati A, Schena F, Marengo E, Krampera M, Galie M. J Cell Sci. 2021 Jun 1;134(11). pii: 269034. doi: 10.1242/jcs.256230. Epub 2021 Jun 7. PubMed |
| SORBS2 is a genetic factor contributing to cardiac malformation of 4q deletion syndrome patients. Liang F, Wang B, Geng J, You G, Fa J, Zhang M, Sun H, Chen H, Fu Q, Zhang X, Zhang Z. Elife. 2021 Jun 8;10. pii: 67481. doi: 10.7554/eLife.67481. PubMed |
| SARS-CoV-2 RNAemia and proteomic trajectories inform prognostication in COVID-19 patients admitted to intensive care. Gutmann C, Takov K, Burnap SA, Singh B, Ali H, Theofilatos K, Reed E, Hasman M, Nabeebaccus A, Fish M, McPhail MJ, O'Gallagher K, Schmidt LE, Cassel C, Rienks M, Yin X, Auzinger G, Napoli S, Mujib SF, Trovato F, Sanderson B, Merrick B, Niazi U, Saqi M, Dimitrakopoulou K, Fernandez-Leiro R, Braun S, Kronstein-Wiedemann R, Doores KJ, Edgeworth JD, Shah AM, Bornstein SR, Tonn T, Hayday AC, Giacca M, Shankar-Hari M, Mayr M. Nat Commun. 2021 Jun 7;12(1):3406. doi: 10.1038/s41467-021-23494-1. PubMed |
| HOXA13 in etiology and oncogenic potential of Barrett's esophagus. Janmaat VT, Nesteruk K, Spaander MCW, Verhaar AP, Yu B, Silva RA, Phillips WA, Magierowski M, van de Winkel A, Stadler HS, Sandoval-Guzman T, van der Laan LJW, Kuipers EJ, Smits R, Bruno MJ, Fuhler GM, Clemons NJ, Peppelenbosch MP. Nat Commun. 2021 Jun 7;12(1):3354. doi: 10.1038/s41467-021-23641-8. PubMed |
| A cell-free assay implicates a role of sphingomyelin and cholesterol in STING phosphorylation. Takahashi K, Niki T, Ogawa E, Fumika K, Nishioka Y, Sawa M, Arai H, Mukai K, Taguchi T. Sci Rep. 2021 Jun 7;11(1):11996. doi: 10.1038/s41598-021-91562-z. PubMed |
| NORAD-induced Pumilio phase separation is required for genome stability. Elguindy MM, Mendell JT. Nature. 2021 Jul;595(7866):303-308. doi: 10.1038/s41586-021-03633-w. Epub 2021 Jun 9. PubMed |
| HGK promotes metastatic dissemination in prostate cancer. Garcia-Garcia S, Rodrigo-Faus M, Fonseca N, Manzano S, Gyorffy B, Ocana A, Bragado P, Porras A, Gutierrez-Uzquiza A. Sci Rep. 2021 Jun 10;11(1):12287. doi: 10.1038/s41598-021-91292-2. PubMed |
| TP73-AS1 is induced by YY1 during TMZ treatment and highly expressed in the aging brain. Mazor G, Smirnov D, Ben David H, Khrameeva E, Toiber D, Rotblat B. Aging (Albany NY). 2021 Jun 11;13(11):14843-14861. doi: 10.18632/aging.203182. Epub 2021 Jun 11. PubMed |
| Oxytocin receptor is a promising therapeutic target of malignant mesothelioma. Kodama Y, Tanaka I, Sato T, Hori K, Gen S, Morise M, Matsubara D, Sato M, Sekido Y, Hashimoto N. Cancer Sci. 2021 Sep;112(9):3520-3532. doi: 10.1111/cas.15025. Epub 2021 Jul 4. PubMed |
| Targeting Glucose Metabolism Sensitizes Pancreatic Cancer to MEK Inhibition. Yan L, Tu B, Yao J, Gong J, Carugo A, Bristow CA, Wang Q, Zhu C, Dai B, Kang Y, Han L, Feng N, Jin Y, Fleming J, Heffernan TP, Yao W, Ying H. Cancer Res. 2021 Aug 1;81(15):4054-4065. doi: 10.1158/0008-5472.CAN-20-3792. Epub 2021 Jun 11. PubMed |
| Non-conditioned bone marrow chimeric mouse generation using culture-based enrichment of hematopoietic stem and progenitor cells. Ochi K, Morita M, Wilkinson AC, Iwama A, Yamazaki S. Nat Commun. 2021 Jun 11;12(1):3568. doi: 10.1038/s41467-021-23763-z. PubMed |
| Fatty Acids Activate the Transcriptional Coactivator YAP1 to Promote Liver Fibrosis via p38 Mitogen-Activated Protein Kinase. Salloum S, Jeyarajan AJ, Kruger AJ, Holmes JA, Shao T, Sojoodi M, Kim MH, Zhuo Z, Shroff SG, Kassa A, Corey KE, Khan SK, Lin W, Alatrakchi N, Schaefer EAK, Chung RT. Cell Mol Gastroenterol Hepatol. 2021 Jun 9;12(4):1297-1310. doi: 10.1016/j.jcmgh.2021.06.003. PubMed |
| Generation of recombinant antibodies by mammalian expression system for detecting S-metolachlor in environmental waters. Yu X, Zhang X, Xu J, Guo P, Li X, Wang H, Xu Z, Lei H, Shen X. J Hazard Mater. 2021 Sep 15;418:126305. doi: 10.1016/j.jhazmat.2021.126305. Epub 2021 Jun 5. PubMed |
| Positive natural selection of N6-methyladenosine on the RNAs of processed pseudogenes. Tan L, Cheng W, Liu F, Wang DO, Wu L, Cao N, Wang J. Genome Biol. 2021 Jun 13;22(1):180. doi: 10.1186/s13059-021-02402-2. PubMed |
| In vitro discovery of novel prokaryotic ion channel candidates for antiarrhythmic gene therapy. Wu T, Nguyen HX, Bursac N. Methods Enzymol. 2021;654:407-434. doi: 10.1016/bs.mie.2021.03.008. Epub 2021 Apr 9. PubMed |
| Extracellular signal-regulated kinase mediates chromatin rewiring and lineage transformation in lung cancer. Inoue Y, Nikolic A, Farnsworth D, Shi R, Johnson FD, Liu A, Ladanyi M, Somwar R, Gallo M, Lockwood WW. Elife. 2021 Jun 14;10. pii: 66524. doi: 10.7554/eLife.66524. PubMed |
| NLRP3 Inflammasome Assembly in Neutrophils Is Supported by PAD4 and Promotes NETosis Under Sterile Conditions. Munzer P, Negro R, Fukui S, di Meglio L, Aymonnier K, Chu L, Cherpokova D, Gutch S, Sorvillo N, Shi L, Magupalli VG, Weber ANR, Scharf RE, Waterman CM, Wu H, Wagner DD. Front Immunol. 2021 May 28;12:683803. doi: 10.3389/fimmu.2021.683803. eCollection 2021. PubMed |
| Caspase-Dependent Cleavage of DDX21 Suppresses Host Innate Immunity. Wu W, Qu Y, Yu S, Wang S, Yin Y, Liu Q, Meng C, Liao Y, Ur Rehman Z, Tan L, Song C, Qiu X, Liu W, Ding C, Sun Y. mBio. 2021 Jun 29;12(3):e0100521. doi: 10.1128/mBio.01005-21. Epub 2021 Jun 14. PubMed |
| p38 inhibition enhances TCR-T cell function and antagonizes the immunosuppressive activity of TGF-beta. Chen S, Zhang J, Shen M, Han X, Li S, Hu C, Wang W, Li L, Du L, Pang D, Tao K, Jin A. Int Immunopharmacol. 2021 Sep;98:107848. doi: 10.1016/j.intimp.2021.107848. Epub 2021 Jun 11. PubMed |
| Multiplex protein profiling method for extracellular vesicle protein detection. Sun L, Meckes DG Jr. Sci Rep. 2021 Jun 14;11(1):12477. doi: 10.1038/s41598-021-92012-6. PubMed |
| CRISPR mediated targeting of DUX4 distal regulatory element represses DUX4 target genes dysregulated in Facioscapulohumeral muscular dystrophy. Das S, Chadwick BP. Sci Rep. 2021 Jun 15;11(1):12598. doi: 10.1038/s41598-021-92096-0. PubMed |
| VPS13D interacts with VCP/p97 and negatively regulates endoplasmic reticulum-mitochondria interactions. Du Y, Wang J, Xiong J, Fang N, Ji WK. Mol Biol Cell. 2021 Aug 1;32(16):1474-1486. doi: 10.1091/mbc.E21-03-0097. Epub 2021 Jun 16. PubMed |
| Pathogenic effect of TP73 Gene Variants in People With Amyotrophic Lateral Sclerosis. Russell KL, Downie JM, Gibson SB, Tsetsou S, Keefe MD, Duran JA, Figueroa KP, Bromberg MB, Murtaugh LC, Bonkowsky JL, Pulst SM, Jorde LB. Neurology. 2021 Jun 16. pii: WNL.0000000000012285. doi: 10.1212/WNL.0000000000012285. PubMed |
| A Novel Invadopodia-Specific Marker for Invasive and Pro-Metastatic Cancer Stem Cells. Huang SS, Liao WY, Hsu CC, Chan TS, Liao TY, Yang PM, Chen LT, Sung SY, Tsai KK. Front Oncol. 2021 May 31;11:638311. doi: 10.3389/fonc.2021.638311. eCollection 2021. PubMed |
| Genome-scale CRISPR-Cas9 screen of Wnt/beta-catenin signaling identifies therapeutic targets for colorectal cancer. Wan C, Mahara S, Sun C, Doan A, Chua HK, Xu D, Bian J, Li Y, Zhu D, Sooraj D, Cierpicki T, Grembecka J, Firestein R. Sci Adv. 2021 May 19;7(21). pii: 7/21/eabf2567. doi: 10.1126/sciadv.abf2567. Print 2021 May. PubMed |
| Fusion transcripts FYN-TRAF3IP2 and KHDRBS1-LCK hijack T cell receptor signaling in peripheral T-cell lymphoma, not otherwise specified. Debackere K, Marcelis L, Demeyer S, Vanden Bempt M, Mentens N, Gielen O, Jacobs K, Broux M, Verhoef G, Michaux L, Graux C, Wlodarska I, Gaulard P, de Leval L, Tousseyn T, Cools J, Dierickx D. Nat Commun. 2021 Jun 17;12(1):3705. doi: 10.1038/s41467-021-24037-4. PubMed |
| ULK1 inhibition overcomes compromised antigen presentation and restores antitumor immunity in LKB1 mutant lung cancer. Deng J, Thennavan A, Dolgalev I, Chen T, Li J, Marzio A, Poirier JT, Peng D, Bulatovic M, Mukhopadhyay S, Silver H, Papadopoulos E, Pyon V, Thakurdin C, Han H, Li F, Li S, Ding H, Hu H, Pan Y, Weerasekara V, Jiang B, Wang ES, Ahearn I, Philips M, Papagiannakopoulos T, Tsirigos A, Rothenberg E, Gainor J, Freeman GJ, Rudin CM, Gray NS, Hammerman PS, Pagano M, Heymach JV, Perou CM, Bardeesy N, Wong KK. Nat Cancer. 2021 May;2(5):503-514. doi: 10.1038/s43018-021-00208-6. Epub 2021 May 17. PubMed |
| Mist1 Inhibits Epithelial-Mesenchymal Transition in Gastric Adenocarcinoma via Downregulating the Wnt/beta-catenin Pathway. Xie X, Zhou Z, Song Y, Zhang X, Dang C, Zhang H. J Cancer. 2021 Jun 1;12(15):4574-4584. doi: 10.7150/jca.59138. eCollection 2021. PubMed |
| BECN2 (beclin 2) Negatively Regulates Inflammasome Sensors Through ATG9A-Dependent but ATG16L1- and LC3-Independent Non-Canonical Autophagy. Deng G, Li C, Chen L, Xing C, Fu C, Qian C, Liu X, Wang HY, Zhu M, Wang RF. Autophagy. 2022 Feb;18(2):340-356. doi: 10.1080/15548627.2021.1934270. Epub 2021 Jun 21. PubMed |
| Aberrant activation of Rho/ROCK signaling in impaired polarity switching of colorectal micropapillary carcinoma. Onuma K, Sato Y, Okuyama H, Uematsu H, Homma K, Ohue M, Kondo J, Inoue M. J Pathol. 2021 Sep;255(1):84-94. doi: 10.1002/path.5748. Epub 2021 Jul 16. PubMed |
| Expression regulation and function of PD-1 and PD-L1 in T lymphoma cells. Liu MY, Klement JD, Langan CJ, van Riggelen J, Liu K. Cell Immunol. 2021 Aug;366:104397. doi: 10.1016/j.cellimm.2021.104397. Epub 2021 Jun 17. PubMed |
| CRISPR Interference (CRISPRi) and CRISPR Activation (CRISPRa) to Explore the Oncogenic lncRNA Network. Morelli E, Gulla' A, Amodio N, Taiana E, Neri A, Fulciniti M, Munshi NC. Methods Mol Biol. 2021;2348:189-204. doi: 10.1007/978-1-0716-1581-2_13. PubMed |
| DDB1 binds histone reader BRWD3 to activate the transcriptional cascade in adipogenesis and promote onset of obesity. Wang X, Wang HY, Hu GS, Tang WS, Weng L, Zhang Y, Guo H, Yao SS, Liu SY, Zhang GL, Han Y, Liu M, Zhang XD, Cen X, Shen HF, Xiao N, Liu CQ, Wang HR, Huang J, Liu W, Li P, Zhao TJ. Cell Rep. 2021 Jun 22;35(12):109281. doi: 10.1016/j.celrep.2021.109281. PubMed |
| Nuclear ADP-ribosylation drives IFNgamma-dependent STAT1alpha enhancer formation in macrophages. Gupte R, Nandu T, Kraus WL. Nat Commun. 2021 Jun 24;12(1):3931. doi: 10.1038/s41467-021-24225-2. PubMed |
Rapid generation of potent antibodies by autonomous hypermutation in yeast.
Wellner A, McMahon C, Gilman MSA, Clements JR, Clark S, Nguyen KM, Ho MH, Hu VJ, Shin JE, Feldman J, Hauser BM, Caradonna TM, Wingler LM, Schmidt AG, Marks DS, Abraham J, Kruse AC, Liu CC.
Nat Chem Biol. 2021 Jun 24. pii: 10.1038/s41589-021-00832-4. doi: 10.1038/s41589-021-00832-4.
PubMed
Associated Plasmids |
| Reduced PHLPP Expression Leads to EGFR-TKI Resistance in Lung Cancer by Activating PI3K-AKT and MAPK-ERK Dual Signaling. Wang W, Xia X, Chen K, Chen M, Meng Y, Lv D, Yang H. Front Oncol. 2021 Jun 8;11:665045. doi: 10.3389/fonc.2021.665045. eCollection 2021. PubMed |
| CHK1 inhibitor sensitizes resistant colorectal cancer stem cells to nortopsentin. Di Franco S, Parrino B, Gaggianesi M, Pantina VD, Bianca P, Nicotra A, Mangiapane LR, Lo Iacono M, Ganduscio G, Veschi V, Brancato OR, Glaviano A, Turdo A, Pillitteri I, Colarossi L, Cascioferro S, Carbone D, Pecoraro C, Fiori ME, De Maria R, Todaro M, Screpanti I, Cirrincione G, Diana P, Stassi G. iScience. 2021 May 29;24(6):102664. doi: 10.1016/j.isci.2021.102664. eCollection 2021 Jun 25. PubMed |
| Protocol to establish a lung adenocarcinoma immunotherapy allograft mouse model with FACS and immunofluorescence-based analysis of tumor response. Peng Z, Yu M, Lin J, Dong T, Zhang X, Shi M, Qin M, Li S, Guo W, Zhang H, Sun S. STAR Protoc. 2021 Jun 11;2(2):100595. doi: 10.1016/j.xpro.2021.100595. eCollection 2021 Jun 18. PubMed |
| BAP1/ASXL complex modulation regulates epithelial-mesenchymal transition during trophoblast differentiation and invasion. Perez-Garcia V, Lea G, Lopez-Jimenez P, Okkenhaug H, Burton GJ, Moffett A, Turco MY, Hemberger M. Elife. 2021 Jun 25;10. pii: 63254. doi: 10.7554/eLife.63254. PubMed |
| Low-Density Lipoprotein Receptor-Related Protein 6 Cell Surface Availability Regulates Fuel Metabolism in Astrocytes. Chow HM, Sun JK, Hart RP, Cheng KK, Hung CHL, Lau TM, Kwan KM. Adv Sci (Weinh). 2021 Aug;8(16):e2004993. doi: 10.1002/advs.202004993. Epub 2021 Jun 27. PubMed |
| The endogenous cellular protease inhibitor SPINT2 controls SARS-CoV-2 viral infection and is associated to disease severity. Ramirez Alvarez C, Kee C, Sharma AK, Thomas L, Schmidt FI, Stanifer ML, Boulant S, Herrmann C. PLoS Pathog. 2021 Jun 28;17(6):e1009687. doi: 10.1371/journal.ppat.1009687. eCollection 2021 Jun. PubMed |
Epitranscriptomic editing of the RNA N6-methyladenosine modification by dCasRx conjugated methyltransferase and demethylase.
Xia Z, Tang M, Ma J, Zhang H, Gimple RC, Prager BC, Tang H, Sun C, Liu F, Lin P, Mei Y, Du R, Rich JN, Xie Q.
Nucleic Acids Res. 2021 Jul 21;49(13):7361-7374. doi: 10.1093/nar/gkab517.
PubMed
Associated Plasmids |
| The long non-coding RNA betaFaar regulates islet beta-cell function and survival during obesity in mice. Zhang F, Yang Y, Chen X, Liu Y, Hu Q, Huang B, Liu Y, Pan Y, Zhang Y, Liu D, Liang R, Li G, Wei Q, Li L, Jin L. Nat Commun. 2021 Jun 28;12(1):3997. doi: 10.1038/s41467-021-24302-6. PubMed |
| Osmotic pressure modulates single cell cycle dynamics inducing reversible growth arrest and reactivation of human metastatic cells. Taieb HM, Garske DS, Contzen J, Gossen M, Bertinetti L, Robinson T, Cipitria A. Sci Rep. 2021 Jun 29;11(1):13455. doi: 10.1038/s41598-021-92054-w. PubMed |
| Extracellular vesicles carry SARS-CoV-2 spike protein and serve as decoys for neutralizing antibodies. Troyer Z, Alhusaini N, Tabler CO, Sweet T, de Carvalho KIL, Schlatzer DM, Carias L, King CL, Matreyek K, Tilton JC. J Extracell Vesicles. 2021 Jun;10(8):e12112. doi: 10.1002/jev2.12112. Epub 2021 Jun 18. PubMed |
| The Protein Landscape of Chronic Lymphocytic Leukemia (CLL). Meier-Abt F, Lu J, Cannizzaro E, Pohly MF, Kummer S, Pfammatter S, Kunz L, Collins BC, Nadeu F, Lee KS, Xue P, Gwerder M, Roiss M, Hullein J, Scheinost S, Dietrich S, Campo E, Huber W, Aebersold R, Zenz T. Blood. 2021 Jun 29. pii: S0006-4971(21)01293-3. doi: 10.1182/blood.2020009741. PubMed |
| A T cell redirection platform for co-targeting dual antigens on solid tumors. Enderle L, Shalaby KH, Gorelik M, Weiss A, Blazer LL, Paduch M, Cardarelli L, Kossiakoff A, Adams JJ, Sidhu SS. MAbs. 2021 Jan-Dec;13(1):1933690. doi: 10.1080/19420862.2021.1933690. PubMed |
| Zika Virus Hijacks Extracellular Vesicle Tetraspanin Pathways for Cell-to-Cell Transmission. York SB, Sun L, Cone AS, Duke LC, Cheerathodi MR, Meckes DG Jr. mSphere. 2021 Jun 30:e0019221. doi: 10.1128/mSphere.00192-21. PubMed |
| Breast tumor stiffness instructs bone metastasis via maintenance of mechanical conditioning. Watson AW, Grant AD, Parker SS, Hill S, Whalen MB, Chakrabarti J, Harman MW, Roman MR, Forte BL, Gowan CC, Castro-Portuguez R, Stolze LK, Franck C, Cusanovich DA, Zavros Y, Padi M, Romanoski CE, Mouneimne G. Cell Rep. 2021 Jun 29;35(13):109293. doi: 10.1016/j.celrep.2021.109293. PubMed |
| Revealing molecular pathways for cancer cell fitness through a genetic screen of the cancer translatome. Kuzuoglu-Ozturk D, Hu Z, Rama M, Devericks E, Weiss J, Chiang GG, Worland ST, Brenner SE, Goodarzi H, Gilbert LA, Ruggero D. Cell Rep. 2021 Jun 29;35(13):109321. doi: 10.1016/j.celrep.2021.109321. PubMed |
| Shape of promoter antisense RNAs regulates ligand-induced transcription activation. Yang F, Tanasa B, Micheletti R, Ohgi KA, Aggarwal AK, Rosenfeld MG. Nature. 2021 Jul;595(7867):444-449. doi: 10.1038/s41586-021-03589-x. Epub 2021 Jun 30. PubMed |
| NADH Fluorescence Lifetime Imaging Microscopy Reveals Selective Mitochondrial Dysfunction in Neurons Overexpressing Alzheimer's Disease-Related Proteins. Niederschweiberer MA, Schaefer PM, Singh LN, Lausser L, Bhosale D, Hesse R, Calzia E, Kestler HA, Rueck A, Wallace DC, von Einem B, von Arnim CAF. Front Mol Biosci. 2021 Jun 14;8:671274. doi: 10.3389/fmolb.2021.671274. eCollection 2021. PubMed |
| CAR T cells targeting tumor-associated exons of glypican 2 regress neuroblastoma in mice. Li N, Torres MB, Spetz MR, Wang R, Peng L, Tian M, Dower CM, Nguyen R, Sun M, Tai CH, de Val N, Cachau R, Wu X, Hewitt SM, Kaplan RN, Khan J, St Croix B, Thiele CJ, Ho M. Cell Rep Med. 2021 Jun 1;2(6):100297. doi: 10.1016/j.xcrm.2021.100297. eCollection 2021 Jun 15. PubMed |
| Microtubule Acetylation Controls MDA-MB-231 Breast Cancer Cell Invasion through the Modulation of Endoplasmic Reticulum Stress. Ko P, Choi JH, Song S, Keum S, Jeong J, Hwang YE, Kim JW, Rhee S. Int J Mol Sci. 2021 Jun 2;22(11). pii: ijms22116018. doi: 10.3390/ijms22116018. PubMed |
| Balancing the CD38 Expression on Effector and Target Cells in Daratumumab-Mediated NK Cell ADCC against Multiple Myeloma. Lejeune M, Duray E, Peipp M, Clemenceau B, Baron F, Beguin Y, Caers J. Cancers (Basel). 2021 Jun 20;13(12). pii: cancers13123072. doi: 10.3390/cancers13123072. PubMed |
| African Swine Fever Virus Ubiquitin-Conjugating Enzyme Is an Immunomodulator Targeting NF-kappaB Activation. Barrado-Gil L, Del Puerto A, Galindo I, Cuesta-Geijo MA, Garcia-Dorival I, de Motes CM, Alonso C. Viruses. 2021 Jun 17;13(6). pii: v13061160. doi: 10.3390/v13061160. PubMed |
| Overexpression of Replication-Dependent Histone Signifies a Subset of Dedifferentiated Liposarcoma with Increased Aggressiveness. Yoo Y, Park SY, Jo EB, Choi M, Lee KW, Hong D, Lee S, Lee CR, Lee Y, Um JY, Park JB, Seo SW, Choi YL, Kim S, Lee SG, Choi M. Cancers (Basel). 2021 Jun 22;13(13). pii: cancers13133122. doi: 10.3390/cancers13133122. PubMed |
| Concurrent mutations in RNA-dependent RNA polymerase and spike protein emerged as the epidemiologically most successful SARS-CoV-2 variant. Ilmjarv S, Abdul F, Acosta-Gutierrez S, Estarellas C, Galdadas I, Casimir M, Alessandrini M, Gervasio FL, Krause KH. Sci Rep. 2021 Jul 1;11(1):13705. doi: 10.1038/s41598-021-91662-w. PubMed |
| The RNA sensor MDA5 detects SARS-CoV-2 infection. Sampaio NG, Chauveau L, Hertzog J, Bridgeman A, Fowler G, Moonen JP, Dupont M, Russell RA, Noerenberg M, Rehwinkel J. Sci Rep. 2021 Jul 1;11(1):13638. doi: 10.1038/s41598-021-92940-3. PubMed |
| Acidic pH irreversibly activates the signaling enzyme SARM1. Zhao YJ, He WM, Zhao ZY, Li WH, Wang QW, Hou YN, Tan Y, Zhang D. FEBS J. 2021 Jul 2. doi: 10.1111/febs.16104. PubMed |
| Systematic analysis of SARS-CoV-2 infection of an ACE2-negative human airway cell. Puray-Chavez M, LaPak KM, Schrank TP, Elliott JL, Bhatt DP, Agajanian MJ, Jasuja R, Lawson DQ, Davis K, Rothlauf PW, Liu Z, Jo H, Lee N, Tenneti K, Eschbach JE, Shema Mugisha C, Cousins EM, Cloer EW, Vuong HR, VanBlargan LA, Bailey AL, Gilchuk P, Crowe JE Jr, Diamond MS, Hayes DN, Whelan SPJ, Horani A, Brody SL, Goldfarb D, Major MB, Kutluay SB. Cell Rep. 2021 Jul 13;36(2):109364. doi: 10.1016/j.celrep.2021.109364. Epub 2021 Jun 23. PubMed |
| Humans with inherited T cell CD28 deficiency are susceptible to skin papillomaviruses but are otherwise healthy. Beziat V, Rapaport F, Hu J, Titeux M, Bonnet des Claustres M, Bourgey M, Griffin H, Bandet E, Ma CS, Sherkat R, Rokni-Zadeh H, Louis DM, Changi-Ashtiani M, Delmonte OM, Fukushima T, Habib T, Guennoun A, Khan T, Bender N, Rahman M, About F, Yang R, Rao G, Rouzaud C, Li J, Shearer D, Balogh K, Al Ali F, Ata M, Dabiri S, Momenilandi M, Nammour J, Alyanakian MA, Leruez-Ville M, Guenat D, Materna M, Marcot L, Vladikine N, Soret C, Vahidnezhad H, Youssefian L, Saeidian AH, Uitto J, Catherinot E, Navabi SS, Zarhrate M, Woodley DT, Jeljeli M, Abraham T, Belkaya S, Lorenzo L, Rosain J, Bayat M, Lanternier F, Lortholary O, Zakavi F, Gros P, Orth G, Abel L, Pretet JL, Fraitag S, Jouanguy E, Davis MM, Tangye SG, Notarangelo LD, Marr N, Waterboer T, Langlais D, Doorbar J, Hovnanian A, Christensen N, Bossuyt X, Shahrooei M, Casanova JL. Cell. 2021 Jul 8;184(14):3812-3828.e30. doi: 10.1016/j.cell.2021.06.004. Epub 2021 Jul 1. PubMed |
| Non-Structural Protein 5 of Zika Virus Interacts with p53 in Human Neural Progenitor Cells and Induces p53-Mediated Apoptosis. Li P, Jiang H, Peng H, Zeng W, Zhong Y, He M, Xie L, Chen J, Guo D, Wu J, Li CM. Virol Sin. 2021 Jul 5. pii: 10.1007/s12250-021-00422-7. doi: 10.1007/s12250-021-00422-7. PubMed |
| The proteolytic landscape of cells exposed to non-lethal stresses is shaped by executioner caspases. Conde-Rubio MDC, Mylonas R, Widmann C. Cell Death Discov. 2021 Jun 19;7(1):164. doi: 10.1038/s41420-021-00539-4. PubMed |
| Oncogenic KRAS creates an aspartate metabolism signature in colorectal cancer cells. Doubleday PF, Fornelli L, Ntai I, Kelleher NL. FEBS J. 2021 Dec;288(23):6683-6699. doi: 10.1111/febs.16111. Epub 2021 Jul 27. PubMed |
| Receptor Switching in Newly Evolved Adeno-associated Viruses. Havlik LP, Das A, Mietzsch M, Oh DK, Ark J, McKenna R, Agbandje-McKenna M, Asokan A. J Virol. 2021 Sep 9;95(19):e0058721. doi: 10.1128/JVI.00587-21. Epub 2021 Sep 9. PubMed |
| Targeted protein degradation reveals a direct role of SPT6 in RNAPII elongation and termination. Narain A, Bhandare P, Adhikari B, Backes S, Eilers M, Dolken L, Schlosser A, Erhard F, Baluapuri A, Wolf E. Mol Cell. 2021 Aug 5;81(15):3110-3127.e14. doi: 10.1016/j.molcel.2021.06.016. Epub 2021 Jul 6. PubMed |
| The Mediator subunit MED20 organizes the early adipogenic complex to promote development of adipose tissues and diet-induced obesity. Tang WS, Weng L, Wang X, Liu CQ, Hu GS, Yin ST, Tao Y, Hong NN, Guo H, Liu W, Wang HR, Zhao TJ. Cell Rep. 2021 Jul 6;36(1):109314. doi: 10.1016/j.celrep.2021.109314. PubMed |
| Metabolic control of TFH cells and humoral immunity by phosphatidylethanolamine. Fu G, Guy CS, Chapman NM, Palacios G, Wei J, Zhou P, Long L, Wang YD, Qian C, Dhungana Y, Huang H, Kc A, Shi H, Rankin S, Brown SA, Johnson A, Wakefield R, Robinson CG, Liu X, Sheyn A, Yu J, Jackowski S, Chi H. Nature. 2021 Jul;595(7869):724-729. doi: 10.1038/s41586-021-03692-z. Epub 2021 Jul 7. PubMed |
| Prognostic role and biologic features of Musashi-2 expression in colon polyps and during colorectal cancer progression. Kharin L, Bychkov I, Karnaukhov N, Voloshin M, Fazliyeva R, Deneka A, Frantsiyants E, Kit O, Golemis E, Boumber Y. PLoS One. 2021 Jul 8;16(7):e0252132. doi: 10.1371/journal.pone.0252132. eCollection 2021. PubMed |
| The multi-functional reovirus sigma3 protein is a virulence factor that suppresses stress granule formation and is associated with myocardial injury. Guo Y, Hinchman MM, Lewandrowski M, Cross ST, Sutherland DM, Welsh OL, Dermody TS, Parker JSL. PLoS Pathog. 2021 Jul 8;17(7):e1009494. doi: 10.1371/journal.ppat.1009494. eCollection 2021 Jul. PubMed |
| The RAS GTPase RIT1 compromises mitotic fidelity through spindle assembly checkpoint suppression. Cuevas-Navarro A, Van R, Cheng A, Urisman A, Castel P, McCormick F. Curr Biol. 2021 Sep 13;31(17):3915-3924.e9. doi: 10.1016/j.cub.2021.06.030. Epub 2021 Jul 7. PubMed |
| PIAS1 potentiates the anti-EBV activity of SAMHD1 through SUMOylation. Saiada F, Zhang K, Li R. Cell Biosci. 2021 Jul 8;11(1):127. doi: 10.1186/s13578-021-00636-y. PubMed |
| lncRNA GAU1 Induces GALNT8 Overexpression and Potentiates Colorectal Cancer Progression. Tang X, Ruan H, Dong L, Li S, Wu Z, Guan M. Gastroenterol Res Pract. 2021 Jun 17;2021:5960821. doi: 10.1155/2021/5960821. eCollection 2021. PubMed |
| ARHGEF26 enhances Salmonella invasion and inflammation in cells and mice. Bourgeois JS, Wang L, Rabino AF, Everitt J, Alvarez MI, Awadia S, Wittchen ES, Garcia-Mata R, Ko DC. PLoS Pathog. 2021 Jul 9;17(7):e1009713. doi: 10.1371/journal.ppat.1009713. eCollection 2021 Jul. PubMed |
| Cholesterol auxotrophy as a targetable vulnerability in clear cell renal cell carcinoma. Riscal R, Bull CJ, Mesaros C, Finan JM, Carens M, Ho ES, Xu JP, Godfrey J, Brennan P, Johansson M, Purdue MP, Chanock SJ, Mariosa D, Timpson NJ, Vincent EE, Keith B, Blair IA, Skuli N, Simon MC. Cancer Discov. 2021 Jul 8. pii: 2159-8290.CD-21-0211. doi: 10.1158/2159-8290.CD-21-0211. PubMed |
| TMEM97 ablation aggravates oxidant-induced retinal degeneration. Shen H, Li J, Heisler-Taylor T, Makin R, Yang H, Mavlyutov TA, Gelfand B, Cebulla CM, Guo LW. Cell Signal. 2021 Oct;86:110078. doi: 10.1016/j.cellsig.2021.110078. Epub 2021 Jul 7. PubMed |
| CD3G or CD3D Knockdown in Mature, but Not Immature, T Lymphocytes Similarly Cripples the Human TCRalphabeta Complex. Garcillan B, Fuentes P, Marin AV, Megino RF, Chacon-Arguedas D, Mazariegos MS, Jimenez-Reinoso A, Munoz-Ruiz M, Laborda RG, Cardenas PP, Fernandez-Malave E, Toribio ML, Regueiro JR. Front Cell Dev Biol. 2021 Jun 25;9:608490. doi: 10.3389/fcell.2021.608490. eCollection 2021. PubMed |
| MicroRNA-324-5p-CUEDC2 Axis Mediates Gain-of-Function Mutant p53-Driven Cancer Stemness. Ghatak D, Datta A, Roychowdhury T, Chattopadhyay S, Roychoudhury S. Mol Cancer Res. 2021 Jul 13. pii: 1541-7786.MCR-20-0717. doi: 10.1158/1541-7786.MCR-20-0717. PubMed |
| circFAT1 Promotes Cancer Stemness and Immune Evasion by Promoting STAT3 Activation. Jia L, Wang Y, Wang CY. Adv Sci (Weinh). 2021 May 2;8(13):2003376. doi: 10.1002/advs.202003376. eCollection 2021 Jul. PubMed |
| HLA class-I-peptide stability mediates CD8(+) T cell immunodominance hierarchies and facilitates HLA-associated immune control of HIV. Kaseke C, Park RJ, Singh NK, Koundakjian D, Bashirova A, Garcia Beltran WF, Takou Mbah OC, Ma J, Senjobe F, Urbach JM, Nathan A, Rossin EJ, Tano-Menka R, Khatri A, Piechocka-Trocha A, Waring MT, Birnbaum ME, Baker BM, Carrington M, Walker BD, Gaiha GD. Cell Rep. 2021 Jul 13;36(2):109378. doi: 10.1016/j.celrep.2021.109378. PubMed |
| The long noncoding RNA HOTAIRM1 controlled by AML1 enhances glucocorticoid resistance by activating RHOA/ROCK1 pathway through suppressing ARHGAP18. Liang L, Gu W, Li M, Gao R, Zhang X, Guo C, Mi S. Cell Death Dis. 2021 Jul 14;12(7):702. doi: 10.1038/s41419-021-03982-4. PubMed |
| Large parental differences in chromatin organization in pancreatic beta cell line explaining diabetes susceptibility effects. Jian X, Felsenfeld G. Nat Commun. 2021 Jul 15;12(1):4338. doi: 10.1038/s41467-021-24635-2. PubMed |
| Squalene epoxidase promotes colorectal cancer cell proliferation through accumulating calcitriol and activating CYP24A1-mediated MAPK signaling. He L, Li H, Pan C, Hua Y, Peng J, Zhou Z, Zhao Y, Lin M. Cancer Commun (Lond). 2021 Aug;41(8):726-746. doi: 10.1002/cac2.12187. Epub 2021 Jul 16. PubMed |
Mutants of human ACE2 differentially promote SARS-CoV and SARS-CoV-2 spike mediated infection.
Shukla N, Roelle SM, Suzart VG, Bruchez AM, Matreyek KA.
PLoS Pathog. 2021 Jul 16;17(7):e1009715. doi: 10.1371/journal.ppat.1009715. eCollection 2021 Jul.
PubMed
Associated Plasmids |
| Glycerol-3-phosphate biosynthesis regenerates cytosolic NAD(+) to alleviate mitochondrial disease. Liu S, Fu S, Wang G, Cao Y, Li L, Li X, Yang J, Li N, Shan Y, Cao Y, Ma Y, Dong M, Liu Q, Jiang H. Cell Metab. 2021 Jul 8. pii: S1550-4131(21)00283-7. doi: 10.1016/j.cmet.2021.06.013. PubMed |
| Selective targeting of ligand-dependent and -independent signaling by GPCR conformation-specific anti-US28 intrabodies. De Groof TWM, Bergkamp ND, Heukers R, Giap T, Bebelman MP, Goeij-de Haas R, Piersma SR, Jimenez CR, Garcia KC, Ploegh HL, Siderius M, Smit MJ. Nat Commun. 2021 Jul 16;12(1):4357. doi: 10.1038/s41467-021-24574-y. PubMed |
| LFA-1 and kindlin-3 enable the collaborative transport of SLP-76 microclusters by myosin and dynein motors. Eidell KP, Lovy A, Sylvain NR, Scangarello FA, Muendlein HI, Ophir MJ, Nguyen K, Seminario MC, Bunnell SC. J Cell Sci. 2021 Aug 15;134(16). pii: 270974. doi: 10.1242/jcs.258602. Epub 2021 Aug 27. PubMed |
| Structure-Guided Design of a "Bump-and-Hole" Bromodomain-Based Degradation Tag. Nowak RP, Xiong Y, Kirmani N, Kalabathula J, Donovan KA, Eleuteri NA, Yuan JC, Fischer ES. J Med Chem. 2021 Aug 12;64(15):11637-11650. doi: 10.1021/acs.jmedchem.1c00958. Epub 2021 Jul 19. PubMed |
| BTK inhibition sensitizes Acute Lymphoblastic Leukemia to asparaginase by suppressing the Amino Acid Response pathway. Butler M, van Ingen Schenau DS, Yu J, Jenni S, Dobay MP, Hagelaar R, Vervoort BMT, Tee TM, Hoff FW, Meijerink JP, Kornblau SM, Bornhauser B, Bourquin JP, Kuiper RP, van der Meer LT, van Leeuwen FN. Blood. 2021 Jul 19. pii: S0006-4971(21)01372-0. doi: 10.1182/blood.2021011787. PubMed |
| Distinct transcription factor networks control neutrophil-driven inflammation. Khoyratty TE, Ai Z, Ballesteros I, Eames HL, Mathie S, Martin-Salamanca S, Wang L, Hemmings A, Willemsen N, von Werz V, Zehrer A, Walzog B, van Grinsven E, Hidalgo A, Udalova IA. Nat Immunol. 2021 Sep;22(9):1093-1106. doi: 10.1038/s41590-021-00968-4. Epub 2021 Jul 19. PubMed |
| Imbalanced autophagy causes synaptic deficits in a human model for neurodevelopmental disorders. Linda K, Lewerissa EI, Verboven AHA, Gabriele M, Frega M, Klein Gunnewiek TM, Devilee L, Ulferts E, Hommersom M, Oudakker A, Schoenmaker C, van Bokhoven H, Schubert D, Testa G, Koolen DA, de Vries BBA, Nadif Kasri N. Autophagy. 2022 Feb;18(2):423-442. doi: 10.1080/15548627.2021.1936777. Epub 2021 Jul 21. PubMed |
| LncRNA PVT1 promotes the progression of ovarian cancer by activating TGF-beta pathway via miR-148a-3p/AGO1 axis. Wu Y, Gu W, Han X, Jin Z. J Cell Mol Med. 2021 Sep;25(17):8229-8243. doi: 10.1111/jcmm.16700. Epub 2021 Jul 21. PubMed |
| Cytokine-induced apoptosis inhibitor 1 (CIAPIN1) accelerates vascular remodelling via p53 and JAK2-STAT3 regulation in vascular smooth muscle cells. Han JH, Heo KS, Myung CS. Br J Pharmacol. 2021 Jul 21. doi: 10.1111/bph.15631. PubMed |
| Seroprevalence of SARS-CoV-2 antibodies among rural healthcare workers. Neises JZ, Hossain MS, Sultana R, Wanniarachchi KN, Wollman JW, Nelson E, Specker BL, Hoppe AD, Lawson SR, Thiex NW. J Med Virol. 2021 Jul 21. doi: 10.1002/jmv.27224. PubMed |
| CD19/CD22 Dual-Targeted CAR T-cell Therapy for Relapsed/Refractory Aggressive B-cell Lymphoma: A Safety and Efficacy Study. Wei G, Zhang Y, Zhao H, Wang Y, Liu Y, Liang B, Wang X, Xu H, Cui J, Wu W, Zhao K, Nagler A, Chang AH, Hu Y, Huang H. Cancer Immunol Res. 2021 Sep;9(9):1061-1070. doi: 10.1158/2326-6066.CIR-20-0675. Epub 2021 Jul 21. PubMed |
| Nuclear NAD(+) homeostasis governed by NMNAT1 prevents apoptosis of acute myeloid leukemia stem cells. Shi X, Jiang Y, Kitano A, Hu T, Murdaugh RL, Li Y, Hoegenauer KA, Chen R, Takahashi K, Nakada D. Sci Adv. 2021 Jul 21;7(30). pii: 7/30/eabf3895. doi: 10.1126/sciadv.abf3895. Print 2021 Jul. PubMed |
| Machine learning approach for discrimination of genotypes based on bright-field cellular images. Suzuki G, Saito Y, Seki M, Evans-Yamamoto D, Negishi M, Kakoi K, Kawai H, Landry CR, Yachie N, Mitsuyama T. NPJ Syst Biol Appl. 2021 Jul 21;7(1):31. doi: 10.1038/s41540-021-00190-w. PubMed |
| Liposome-mediated detection of SARS-CoV-2 RNA-positive extracellular vesicles in plasma. Ning B, Huang Z, Youngquist BM, Scott JW, Niu A, Bojanowski CM, Zwezdaryk KJ, Saba NS, Fan J, Yin XM, Cao J, Lyon CJ, Li CZ, Roy CJ, Hu TY. Nat Nanotechnol. 2021 Sep;16(9):1039-1044. doi: 10.1038/s41565-021-00939-8. Epub 2021 Jul 22. PubMed |
| A conserved ubiquitin- and ESCRT-dependent pathway internalizes human lysosomal membrane proteins for degradation. Zhang W, Yang X, Chen L, Liu YY, Venkatarangan V, Reist L, Hanson P, Xu H, Wang Y, Li M. PLoS Biol. 2021 Jul 23;19(7):e3001361. doi: 10.1371/journal.pbio.3001361. eCollection 2021 Jul. PubMed |
| Deacetylation as a receptor-regulated direct activation switch for pannexin channels. Chiu YH, Medina CB, Doyle CA, Zhou M, Narahari AK, Sandilos JK, Gonye EC, Gao HY, Guo SY, Parlak M, Lorenz UM, Conrads TP, Desai BN, Ravichandran KS, Bayliss DA. Nat Commun. 2021 Jul 23;12(1):4482. doi: 10.1038/s41467-021-24825-y. PubMed |
| Human cell transformation by combined lineage conversion and oncogene expression. Sahu B, Pihlajamaa P, Zhang K, Palin K, Ahonen S, Cervera A, Ristimaki A, Aaltonen LA, Hautaniemi S, Taipale J. Oncogene. 2021 Sep;40(36):5533-5547. doi: 10.1038/s41388-021-01940-0. Epub 2021 Jul 23. PubMed |
| CRISPRi/a Screening with Human iPSCs. Nishiga M, Qi LS, Wu JC. Methods Mol Biol. 2021;2320:261-281. doi: 10.1007/978-1-0716-1484-6_23. PubMed |
| A Structural Study of the Cytoplasmic Chaperone Effect of 14-3-3 Proteins on Ataxin-1. Leysen S, Burnley RJ, Rodriguez E, Milroy LG, Soini L, Adamski CJ, Nitschke L, Davis R, Obsil T, Brunsveld L, Crabbe T, Zoghbi HY, Ottmann C, Davis JM. J Mol Biol. 2021 Sep 17;433(19):167174. doi: 10.1016/j.jmb.2021.167174. Epub 2021 Jul 21. PubMed |
| A human cell-based SARS-CoV-2 vaccine elicits potent neutralizing antibody responses and protects mice from SARS-CoV-2 challenge. He X, Ding L, Cao K, Peng H, Gu C, Li Y, Li D, Dong L, Hong X, Wang X, Fu M, Qiu C, Zhu C, Zhang Z, Song S, Wang C, Jiang Z, Xie Y, Qi Z, Zhao C, Zhao P, Zhang X, Xu J. Emerg Microbes Infect. 2021 Dec;10(1):1555-1573. doi: 10.1080/22221751.2021.1957400. PubMed |
| CRISPR/Cas9-Mediated Whole Genomic Wide Knockout Screening Identifies Specific Genes Associated With PM2.5-Induced Mineral Absorption in Liver Toxicity. Peng J, Yi B, Wang M, Tan J, Huang Z. Front Bioeng Biotechnol. 2021 Jul 7;9:669434. doi: 10.3389/fbioe.2021.669434. eCollection 2021. PubMed |
| Zinc finger antiviral protein (ZAP) inhibits small ruminant morbillivirus replication in vitro. Tang A, Tang J, Miao Q, Zhu J, Guo H, Liu C, Meng C, Li C, Chen Z, Liu G. Vet Microbiol. 2021 Sep;260:109163. doi: 10.1016/j.vetmic.2021.109163. Epub 2021 Jun 23. PubMed |
| An autoimmune disease risk variant: A trans master regulatory effect mediated by IRF1 under immune stimulation? Brandt M, Kim-Hellmuth S, Ziosi M, Gokden A, Wolman A, Lam N, Recinos Y, Daniloski Z, Morris JA, Hornung V, Schumacher J, Lappalainen T. PLoS Genet. 2021 Jul 27;17(7):e1009684. doi: 10.1371/journal.pgen.1009684. eCollection 2021 Jul. PubMed |
| Ribosome ADP-ribosylation inhibits translation and maintains proteostasis in cancers. Challa S, Khulpateea BR, Nandu T, Camacho CV, Ryu KW, Chen H, Peng Y, Lea JS, Kraus WL. Cell. 2021 Aug 19;184(17):4531-4546.e26. doi: 10.1016/j.cell.2021.07.005. Epub 2021 Jul 26. PubMed |
| The Cancer Therapy-Related Clonal Hematopoiesis Driver Gene Ppm1d Promotes Inflammation and Non-Ischemic Heart Failure in Mice. Yura Y, Miura-Yura E, Katanasaka Y, Min KD, Chavkin N, Polizio AH, Ogawa H, Horitani K, Doviak H, Evans MA, Sano M, Wang Y, Boroviak K, Philippos G, Domingues AF, Vassiliou G, Sano S, Walsh K. Circ Res. 2021 Sep 3;129(6):684-698. doi: 10.1161/CIRCRESAHA.121.319314. Epub 2021 Jul 28. PubMed |
| Galphaq activation modulates autophagy by promoting mTORC1 signaling. Cabezudo S, Sanz-Flores M, Caballero A, Tasset I, Rebollo E, Diaz A, Aragay AM, Cuervo AM, Mayor F Jr, Ribas C. Nat Commun. 2021 Jul 27;12(1):4540. doi: 10.1038/s41467-021-24811-4. PubMed |
| RalA and PLD1 promote lipid droplet growth in response to nutrient withdrawal. Hussain SS, Tran TM, Ware TB, Luse MA, Prevost CT, Ferguson AN, Kashatus JA, Hsu KL, Kashatus DF. Cell Rep. 2021 Jul 27;36(4):109451. doi: 10.1016/j.celrep.2021.109451. PubMed |
A Cre-dependent CRISPR/dCas9 system for gene expression regulation in neurons.
Carullo NVN, Hinds JE, Revanna JS, Tuscher JJ, Bauman AJ, Day JJ.
eNeuro. 2021 Jul 26. pii: ENEURO.0188-21.2021. doi: 10.1523/ENEURO.0188-21.2021.
PubMed
Associated Plasmids |
PALI1 facilitates DNA and nucleosome binding by PRC2 and triggers an allosteric activation of catalysis.
Zhang Q, Agius SC, Flanigan SF, Uckelmann M, Levina V, Owen BM, Davidovich C.
Nat Commun. 2021 Jul 28;12(1):4592. doi: 10.1038/s41467-021-24866-3.
PubMed
Associated Plasmids |
| Identification of a Three-RNA Binding Proteins (RBPs) Signature Predicting Prognosis for Breast Cancer. Liu Y, Sun H, Li X, Liu Q, Zhao Y, Li L, Xu B, Hou Y, Jin W. Front Oncol. 2021 Jul 12;11:663556. doi: 10.3389/fonc.2021.663556. eCollection 2021. PubMed |
| Inhibition of Janus Kinase 1 synergizes docetaxel sensitivity in prostate cancer cells. Nalairndran G, Chung I, Abdul Razack AH, Chung FF, Hii LW, Lim WM, Looi CK, Mai CW, Leong CO. J Cell Mol Med. 2021 Sep;25(17):8187-8200. doi: 10.1111/jcmm.16684. Epub 2021 Jul 28. PubMed |
| Direct Conversion of Human Fibroblasts to Induced Neurons. Zhou-Yang L, Eichhorner S, Karbacher L, Bohnke L, Traxler L, Mertens J. Methods Mol Biol. 2021;2352:73-96. doi: 10.1007/978-1-0716-1601-7_6. PubMed |
| Single Transcription Factor-Based Differentiation Allowing Fast and Efficient Oligodendrocyte Generation via SOX10 Overexpression. Neyrinck K, Garcia-Leon JA. Methods Mol Biol. 2021;2352:149-170. doi: 10.1007/978-1-0716-1601-7_11. PubMed |
| SKAP2 as a new regulator of oligodendroglial migration and myelin sheath formation. Ghelman J, Grewing L, Windener F, Albrecht S, Zarbock A, Kuhlmann T. Glia. 2021 Nov;69(11):2699-2716. doi: 10.1002/glia.24066. Epub 2021 Jul 29. PubMed |
| WDR5-H3K4me3 epigenetic axis regulates OPN expression to compensate PD-L1 function to promote pancreatic cancer immune escape. Lu C, Liu Z, Klement JD, Yang D, Merting AD, Poschel D, Albers T, Waller JL, Shi H, Liu K. J Immunother Cancer. 2021 Jul;9(7). pii: jitc-2021-002624. doi: 10.1136/jitc-2021-002624. PubMed |
| Small molecule inhibition of deubiquitinating enzyme JOSD1 as a novel targeted therapy for leukemias with mutant JAK2. Yang J, Weisberg EL, Liu X, Magin RS, Chan WC, Hu B, Schauer NJ, Zhang S, Lamberto I, Doherty L, Meng C, Sattler M, Cabal-Hierro L, Winer E, Stone R, Marto JA, Griffin JD, Buhrlage SJ. Leukemia. 2022 Jan;36(1):210-220. doi: 10.1038/s41375-021-01336-9. Epub 2021 Jul 29. PubMed |
| Allo-Specific Humoral Responses: New Methods for Screening Donor-Specific Antibody and Characterization of HLA-Specific Memory B Cells. Song S, Manook M, Kwun J, Jackson AM, Knechtle SJ, Kelsoe G. Front Immunol. 2021 Jul 13;12:705140. doi: 10.3389/fimmu.2021.705140. eCollection 2021. PubMed |
| AKT3-mediated IWS1 phosphorylation promotes the proliferation of EGFR-mutant lung adenocarcinomas through cell cycle-regulated U2AF2 RNA splicing. Laliotis GI, Chavdoula E, Paraskevopoulou MD, Kaba A, La Ferlita A, Singh S, Anastas V, Nair KA 2nd, Orlacchio A, Taraslia V, Vlachos I, Capece M, Hatzigeorgiou A, Palmieri D, Tsatsanis C, Alaimo S, Sehgal L, Carbone DP, Coppola V, Tsichlis PN. Nat Commun. 2021 Jul 30;12(1):4624. doi: 10.1038/s41467-021-24795-1. PubMed |
| PRMT1-dependent regulation of RNA metabolism and DNA damage response sustains pancreatic ductal adenocarcinoma. Giuliani V, Miller MA, Liu CY, Hartono SR, Class CA, Bristow CA, Suzuki E, Sanz LA, Gao G, Gay JP, Feng N, Rose JL, Tomihara H, Daniele JR, Peoples MD, Bardenhagen JP, Geck Do MK, Chang QE, Vangamudi B, Vellano C, Ying H, Deem AK, Do KA, Genovese G, Marszalek JR, Kovacs JJ, Kim M, Fleming JB, Guccione E, Viale A, Maitra A, Emilia Di Francesco M, Yap TA, Jones P, Draetta G, Carugo A, Chedin F, Heffernan TP. Nat Commun. 2021 Jul 30;12(1):4626. doi: 10.1038/s41467-021-24798-y. PubMed |
| Enhancer decommissioning imposes an epigenetic barrier to sensory hair cell regeneration. Tao L, Yu HV, Llamas J, Trecek T, Wang X, Stojanova Z, Groves AK, Segil N. Dev Cell. 2021 Sep 13;56(17):2471-2485.e5. doi: 10.1016/j.devcel.2021.07.003. Epub 2021 Jul 30. PubMed |
| Elevated LINC00909 Promotes Tumor Progression of Ovarian Cancer via Regulating the miR-23b-3p/MRC2 Axis. Yang X, Wu G, Yang F, He L, Xie X, Li L, Yang L, Ma Y, Zhang Q, Chen J, Zou S, Han Q, Wang Y, Liu S, Li J, Han B, Liu K. Oxid Med Cell Longev. 2021 Jul 21;2021:5574130. doi: 10.1155/2021/5574130. eCollection 2021. PubMed |
| Identification of response signatures for tankyrase inhibitor treatment in tumor cell lines. Mygland L, Brinch SA, Strand MF, Olsen PA, Aizenshtadt A, Lund K, Solberg NT, Lycke M, Thorvaldsen TE, Espada S, Misaghian D, Page CM, Agafonov O, Nygard S, Chi NW, Lin E, Tan J, Yu Y, Costa M, Krauss S, Waaler J. iScience. 2021 Jul 1;24(7):102807. doi: 10.1016/j.isci.2021.102807. eCollection 2021 Jul 23. PubMed |
| STING1 is essential for an RNA-virus triggered autophagy. Zhang R, Qin X, Yang Y, Zhu X, Zhao S, Zhang Z, Su Q, Zhao Z, Yin X, Meng X, Zhang Z, Li Y. Autophagy. 2022 Apr;18(4):816-828. doi: 10.1080/15548627.2021.1959086. Epub 2021 Aug 2. PubMed |
| Klotho inhibits neuronal senescence in human brain organoids. Shaker MR, Aguado J, Chaggar HK, Wolvetang EJ. NPJ Aging Mech Dis. 2021 Aug 2;7(1):18. doi: 10.1038/s41514-021-00070-x. PubMed |
| Mammalian acetate-dependent acetyl CoA synthetase 2 contains multiple protein destabilization and masking elements. Nagati JS, Kobeissy PH, Nguyen MQ, Xu M, Garcia T, Comerford SA, Hammer RE, Garcia JA. J Biol Chem. 2021 Sep;297(3):101037. doi: 10.1016/j.jbc.2021.101037. Epub 2021 Jul 31. PubMed |
| Phosphorylated cingulin localises GEF-H1 at tight junctions to protect vascular barriers in blood endothelial cells. Holzner S, Bromberger S, Wenzina J, Neumuller K, Holper TM, Petzelbauer P, Bauer W, Weber B, Schossleitner K. J Cell Sci. 2021 Sep 1;134(17). pii: 271985. doi: 10.1242/jcs.258557. Epub 2021 Sep 2. PubMed |
| CD13 orients the apical-basal polarity axis necessary for lumen formation. Wang LT, Rajah A, Brown CM, McCaffrey L. Nat Commun. 2021 Aug 4;12(1):4697. doi: 10.1038/s41467-021-24993-x. PubMed |
| Alternol triggers immunogenic cell death via reactive oxygen species generation. Li C, Zhang Y, Yan S, Zhang G, Wei W, Qi Z, Li B. Oncoimmunology. 2021 Jul 21;10(1):1952539. doi: 10.1080/2162402X.2021.1952539. eCollection 2021. PubMed |
| Ubiquitin-Like Protein UBD Promotes Cell Proliferation in Colorectal Cancer by Facilitating p53 Degradation. Su H, Qin M, Liu Q, Jin B, Shi X, Xiang Z. Front Oncol. 2021 Jul 14;11:691347. doi: 10.3389/fonc.2021.691347. eCollection 2021. PubMed |
| The biochemical basis of mitochondrial dysfunction in Zellweger Spectrum Disorder. Nuebel E, Morgan JT, Fogarty S, Winter JM, Lettlova S, Berg JA, Chen YC, Kidwell CU, Maschek JA, Clowers KJ, Argyriou C, Chen L, Wittig I, Cox JE, Roh-Johnson M, Braverman N, Bonkowsky J, Gygi SP, Rutter J. EMBO Rep. 2021 Oct 5;22(10):e51991. doi: 10.15252/embr.202051991. Epub 2021 Aug 5. PubMed |
| Responsiveness to perturbations is a hallmark of transcription factors that maintain cell identity in vitro. Mellis IA, Edelstein HI, Truitt R, Goyal Y, Beck LE, Symmons O, Dunagin MC, Linares Saldana RA, Shah PP, Perez-Bermejo JA, Padmanabhan A, Yang W, Jain R, Raj A. Cell Syst. 2021 Sep 22;12(9):885-899.e8. doi: 10.1016/j.cels.2021.07.003. Epub 2021 Aug 4. PubMed |
| ERAD components Derlin-1 and Derlin-2 are essential for postnatal brain development and motor function. Sugiyama T, Murao N, Kadowaki H, Takao K, Miyakawa T, Matsushita Y, Katagiri T, Futatsugi A, Shinmyo Y, Kawasaki H, Sakai J, Shiomi K, Nakazato M, Takeda K, Mikoshiba K, Ploegh HL, Ichijo H, Nishitoh H. iScience. 2021 Jun 19;24(7):102758. doi: 10.1016/j.isci.2021.102758. eCollection 2021 Jul 23. PubMed |
| The stressosome, a caspase-8-activating signalling complex assembled in response to cell stress in an ATG5-mediated manner. Mnich K, Koryga I, Pakos-Zebrucka K, Thomas M, Logue SE, Eriksson LA, Gorman AM, Samali A. J Cell Mol Med. 2021 Sep;25(18):8809-8820. doi: 10.1111/jcmm.16840. Epub 2021 Aug 7. PubMed |
| BioID reveals an ATG9A interaction with ATG13-ATG101 in the degradation of p62/SQSTM1-ubiquitin clusters. Kannangara AR, Poole DM, McEwan CM, Youngs JC, Weerasekara VK, Thornock AM, Lazaro MT, Balasooriya ER, Oh LM, Soderblom EJ, Lee JJ, Simmons DL, Andersen JL. EMBO Rep. 2021 Aug 9:e51136. doi: 10.15252/embr.202051136. PubMed |
| Activation of bivalent factor DLX5 cooperates with master regulator TP63 to promote squamous cell carcinoma. Huang Y, Yang Q, Zheng Y, Lin L, Xu X, Xu XE, Silva TC, Hazawa M, Peng L, Cao H, Ding Y, Lu D, Berman BP, Xu LY, Li EM, Yin D. Nucleic Acids Res. 2021 Sep 20;49(16):9246-9263. doi: 10.1093/nar/gkab679. PubMed |
| AHR mediates the aflatoxin B1 toxicity associated with hepatocellular carcinoma. Zhu Q, Ma Y, Liang J, Wei Z, Li M, Zhang Y, Liu M, He H, Qu C, Cai J, Wang X, Zeng Y, Jiao Y. Signal Transduct Target Ther. 2021 Aug 9;6(1):299. doi: 10.1038/s41392-021-00713-1. PubMed |
| Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer. Vichas A, Riley AK, Nkinsi NT, Kamlapurkar S, Parrish PCR, Lo A, Duke F, Chen J, Fung I, Watson J, Rees M, Gabel AM, Thomas JD, Bradley RK, Lee JK, Hatch EM, Baine MK, Rekhtman N, Ladanyi M, Piccioni F, Berger AH. Nat Commun. 2021 Aug 9;12(1):4789. doi: 10.1038/s41467-021-24841-y. PubMed |
| The structural dynamics of macropinosome formation and PI3-kinase-mediated sealing revealed by lattice light sheet microscopy. Quinn SE, Huang L, Kerkvliet JG, Swanson JA, Smith S, Hoppe AD, Anderson RB, Thiex NW, Scott BL. Nat Commun. 2021 Aug 10;12(1):4838. doi: 10.1038/s41467-021-25187-1. PubMed |
| Actinin BioID reveals sarcomere crosstalk with oxidative metabolism through interactions with IGF2BP2. Ladha FA, Thakar K, Pettinato AM, Legere N, Ghahremani S, Cohn R, Romano R, Meredith E, Chen YS, Hinson JT. Cell Rep. 2021 Aug 10;36(6):109512. doi: 10.1016/j.celrep.2021.109512. PubMed |
| GOT1 inhibition promotes pancreatic cancer cell death by ferroptosis. Kremer DM, Nelson BS, Lin L, Yarosz EL, Halbrook CJ, Kerk SA, Sajjakulnukit P, Myers A, Thurston G, Hou SW, Carpenter ES, Andren AC, Nwosu ZC, Cusmano N, Wisner S, Mbah NE, Shan M, Das NK, Magnuson B, Little AC, Savani MR, Ramos J, Gao T, Sastra SA, Palermo CF, Badgley MA, Zhang L, Asara JM, McBrayer SK, di Magliano MP, Crawford HC, Shah YM, Olive KP, Lyssiotis CA. Nat Commun. 2021 Aug 11;12(1):4860. doi: 10.1038/s41467-021-24859-2. PubMed |
| USP12 downregulation orchestrates a protumourigenic microenvironment and enhances lung tumour resistance to PD-1 blockade. Yang Z, Xu G, Wang B, Liu Y, Zhang L, Jing T, Tang M, Xu X, Jiao K, Xiang L, Fu Y, Tang D, Zhang X, Jin W, Zhuang G, Zhao X, Liu Y. Nat Commun. 2021 Aug 11;12(1):4852. doi: 10.1038/s41467-021-25032-5. PubMed |
| The extracellular chaperone Clusterin enhances Tau aggregate seeding in a cellular model. Yuste-Checa P, Trinkaus VA, Riera-Tur I, Imamoglu R, Schaller TF, Wang H, Dudanova I, Hipp MS, Bracher A, Hartl FU. Nat Commun. 2021 Aug 11;12(1):4863. doi: 10.1038/s41467-021-25060-1. PubMed |
| Loss of grand histone H3 lysine 27 trimethylation domains mediated transcriptional activation in esophageal squamous cell carcinoma. Yuan J, Jiang Q, Gong T, Fan D, Zhang J, Chen F, Zhu X, Wang X, Qiao Y, Chen H, Liu Z, Su J. NPJ Genom Med. 2021 Aug 11;6(1):65. doi: 10.1038/s41525-021-00232-6. PubMed |
| Export of RNA-derived modified nucleosides by equilibrative nucleoside transporters defines the magnitude of autophagy response and Zika virus replication. Shi SL, Fukuda H, Chujo T, Kouwaki T, Oshiumi H, Tomizawa K, Wei FY. RNA Biol. 2021 Oct 15;18(sup1):478-495. doi: 10.1080/15476286.2021.1960689. Epub 2021 Aug 12. PubMed |
| Discovery of ciliary G protein-coupled receptors regulating pancreatic islet insulin and glucagon secretion. Wu CT, Hilgendorf KI, Bevacqua RJ, Hang Y, Demeter J, Kim SK, Jackson PK. Genes Dev. 2021 Sep 1;35(17-18):1243-1255. doi: 10.1101/gad.348261.121. Epub 2021 Aug 12. PubMed |
| Spontaneous hydrolysis and spurious metabolic properties of alpha-ketoglutarate esters. Parker SJ, Encarnacion-Rosado J, Hollinshead KER, Hollinshead DM, Ash LJ, Rossi JAK, Lin EY, Sohn ASW, Philips MR, Jones DR, Kimmelman AC. Nat Commun. 2021 Aug 12;12(1):4905. doi: 10.1038/s41467-021-25228-9. PubMed |
| Enhanced intratumoural activity of CAR T cells engineered to produce immunomodulators under photothermal control. Miller IC, Zamat A, Sun LK, Phuengkham H, Harris AM, Gamboa L, Yang J, Murad JP, Priceman SJ, Kwong GA. Nat Biomed Eng. 2021 Nov;5(11):1348-1359. doi: 10.1038/s41551-021-00781-2. Epub 2021 Aug 12. PubMed |
| Restoration of the ATG5-dependent autophagy sensitizes DU145 prostate cancer cells to chemotherapeutic drugs. Peng K, Sun A, Zhu J, Gao J, Li Y, Shao G, Yang W, Lin Q. Oncol Lett. 2021 Sep;22(3):638. doi: 10.3892/ol.2021.12899. Epub 2021 Jul 6. PubMed |
| Enhanced cGAS-STING-dependent interferon signaling associated with mutations in ATAD3A. Lepelley A, Della Mina E, Van Nieuwenhove E, Waumans L, Fraitag S, Rice GI, Dhir A, Fremond ML, Rodero MP, Seabra L, Carter E, Bodemer C, Buhas D, Callewaert B, de Lonlay P, De Somer L, Dyment DA, Faes F, Grove L, Holden S, Hully M, Kurian MA, McMillan HJ, Suetens K, Tyynismaa H, Chhun S, Wai T, Wouters C, Bader-Meunier B, Crow YJ. J Exp Med. 2021 Oct 4;218(10). pii: 212553. doi: 10.1084/jem.20201560. Epub 2021 Aug 13. PubMed |
| Telomerase therapy reverses vascular senescence and extends lifespan in progeria mice. Mojiri A, Walther BK, Jiang C, Matrone G, Holgate R, Xu Q, Morales E, Wang G, Gu J, Wang R, Cooke JP. Eur Heart J. 2021 Nov 7;42(42):4352-4369. doi: 10.1093/eurheartj/ehab547. PubMed |
| BRD9 is a druggable component of interferon-stimulated gene expression and antiviral activity. Borold J, Eletto D, Busnadiego I, Mair NK, Moritz E, Schiefer S, Schmidt N, Petric PP, Wong WW, Schwemmle M, Hale BG. EMBO Rep. 2021 Oct 5;22(10):e52823. doi: 10.15252/embr.202152823. Epub 2021 Aug 16. PubMed |
| DDX52 knockdown inhibits the growth of prostate cancer cells by regulating c-Myc signaling. Yu W, Ma H, Li J, Ge J, Wang P, Zhou Y, Zhang J, Shi G. Cancer Cell Int. 2021 Aug 16;21(1):430. doi: 10.1186/s12935-021-02128-y. PubMed |
| NF1 regulates mesenchymal glioblastoma plasticity and aggressiveness through the AP-1 transcription factor FOSL1. Marques C, Unterkircher T, Kroon P, Oldrini B, Izzo A, Dramaretska Y, Ferrarese R, Kling E, Schnell O, Nelander S, Wagner EF, Bakiri L, Gargiulo G, Carro MS, Squatrito M. Elife. 2021 Aug 17;10. pii: 64846. doi: 10.7554/eLife.64846. PubMed |
| Placenta-derived interferon-stimulated gene 20 controls ZIKA virus infection. Ding J, Aldo P, Roberts CM, Stabach P, Liu H, You Y, Qiu X, Jeong J, Maxwell A, Lindenbach B, Braddock D, Liao A, Mor G. EMBO Rep. 2021 Oct 5;22(10):e52450. doi: 10.15252/embr.202152450. Epub 2021 Aug 18. PubMed |
| Arhgef2 regulates mitotic spindle orientation in hematopoietic stem cells and is essential for productive hematopoiesis. Chan DCH, Xu J, Vujovic A, Wong N, Gordon V, de Rooij LPMH, Moreira S, Joyce CE, La Rose J, Sandi MJ, Doble BW, Novina CD, Rottapel RK, Hope KJ. Blood Adv. 2021 Aug 24;5(16):3120-3133. doi: 10.1182/bloodadvances.2020002539. PubMed |
| TRAF6 Promoted Tumor Glycolysis in Non-Small-Cell Lung Cancer by Activating the Akt-HIFalpha Pathway. Feng L, Feng S, Nie Z, Deng Y, Xuan Y, Chen X, Lu Y, Liang L, Chen Y. Biomed Res Int. 2021 Aug 6;2021:3431245. doi: 10.1155/2021/3431245. eCollection 2021. PubMed |
| Aging-Associated Differences in Epitranscriptomic m6A Regulation in Response to Acute Cardiac Ischemia/Reperfusion Injury in Female Mice. Su X, Shen Y, Jin Y, Kim IM, Weintraub NL, Tang Y. Front Pharmacol. 2021 Aug 3;12:654316. doi: 10.3389/fphar.2021.654316. eCollection 2021. PubMed |
| Germline SUCLG2 Variants in Patients With Pheochromocytoma and Paraganglioma. Hadrava Vanova K, Pang Y, Krobova L, Kraus M, Nahacka Z, Boukalova S, Pack SD, Zobalova R, Zhu J, Huynh TT, Jochmanova I, Uher O, Hubackova S, Dvorakova S, Garrett TJ, Ghayee HK, Wu X, Schuster B, Knapp PE, Frysak Z, Hartmann I, Nilubol N, Cerny J, Taieb D, Rohlena J, Neuzil J, Yang C, Pacak K. J Natl Cancer Inst. 2022 Jan 11;114(1):130-138. doi: 10.1093/jnci/djab158. PubMed |
| Capturing membrane trafficking events during 3D angiogenic development in vitro. Francis CR, Kushner EJ. Microcirculation. 2022 Oct;29(6-7):e12726. doi: 10.1111/micc.12726. Epub 2021 Aug 29. PubMed |
| A Peptidomimetic Ligand Targeting the Chromodomain of MPP8 Reveals HRP2's Association with the HUSH Complex. Waybright JM, Clinkscales SE, Barnash KD, Budziszewski GR, Rectenwald JM, Chiarella AM, Norris-Drouin JL, Cholensky SH, Pearce KH, Herring LE, McGinty RK, Hathaway NA, James LI. ACS Chem Biol. 2021 Sep 17;16(9):1721-1736. doi: 10.1021/acschembio.1c00429. Epub 2021 Aug 20. PubMed |
| MiR-205-driven downregulation of cholesterol biosynthesis through SQLE-inhibition identifies therapeutic vulnerability in aggressive prostate cancer. Kalogirou C, Linxweiler J, Schmucker P, Snaebjornsson MT, Schmitz W, Wach S, Krebs M, Hartmann E, Puhr M, Muller A, Spahn M, Seitz AK, Frank T, Marouf H, Buchel G, Eckstein M, Kubler H, Eilers M, Saar M, Junker K, Rohrig F, Kneitz B, Rosenfeldt MT, Schulze A. Nat Commun. 2021 Aug 20;12(1):5066. doi: 10.1038/s41467-021-25325-9. PubMed |
| TDO2 Was Downregulated in Hepatocellular Carcinoma and Inhibited Cell Proliferation by Upregulating the Expression of p21 and p27. Yu C, Rao D, Zhu H, Liu Q, Huang W, Zhang L, Liang H, Song J, Ding Z. Biomed Res Int. 2021 Aug 13;2021:4708439. doi: 10.1155/2021/4708439. eCollection 2021. PubMed |
| HIV-1 Vpu Promotes Phagocytosis of Infected CD4(+) T Cells by Macrophages through Downregulation of CD47. Cong L, Sugden SM, Leclair P, Lim CJ, Pham TNQ, Cohen EA. mBio. 2021 Aug 31;12(4):e0192021. doi: 10.1128/mBio.01920-21. Epub 2021 Aug 24. PubMed |
| Caspases Switch off the m(6)A RNA Modification Pathway to Foster the Replication of a Ubiquitous Human Tumor Virus. Zhang K, Zhang Y, Maharjan Y, Sugiokto FG, Wan J, Li R. mBio. 2021 Aug 31;12(4):e0170621. doi: 10.1128/mBio.01706-21. Epub 2021 Aug 24. PubMed |
| Methods for Quantitative Assessment of Protein Degradation. Nowak RP, Yue H, Park EY, Fischer ES. Methods Mol Biol. 2021;2365:247-263. doi: 10.1007/978-1-0716-1665-9_13. PubMed |
| RUSC2 and WDR47 oppositely regulate kinesin-1-dependent distribution of ATG9A to the cell periphery. Guardia CM, Jain A, Mattera R, Friefeld A, Li Y, Bonifacino JS. Mol Biol Cell. 2021 Nov 1;32(21):ar25. doi: 10.1091/mbc.E21-06-0295. Epub 2021 Aug 25. PubMed |
| Downregulation of Hotair or LSD1 Impaired Heart Regeneration in the Neonatal Mouse. Fei Q, Qiu M, Fan G, Zhang B, Wang Q, Zhang S, Wang S, Yang B, Zhang L. DNA Cell Biol. 2021 Sep;40(9):1177-1184. doi: 10.1089/dna.2021.0095. Epub 2021 Aug 24. PubMed |
| Gain-of-function p53(R172H) mutation drives accumulation of neutrophils in pancreatic tumors, promoting resistance to immunotherapy. Siolas D, Vucic E, Kurz E, Hajdu C, Bar-Sagi D. Cell Rep. 2021 Aug 24;36(8):109578. doi: 10.1016/j.celrep.2021.109578. PubMed |
NKD2 mediates stimulation-dependent ORAI1 trafficking to augment Ca(2+) entry in T cells.
Wu B, Woo JS, Vila P, Jew M, Leung J, Sun Z, Srikanth S, Gwack Y.
Cell Rep. 2021 Aug 24;36(8):109603. doi: 10.1016/j.celrep.2021.109603.
PubMed
Associated Plasmids |
| Functional genomics atlas of synovial fibroblasts defining rheumatoid arthritis heritability. Ge X, Frank-Bertoncelj M, Klein K, McGovern A, Kuret T, Houtman M, Burja B, Micheroli R, Shi C, Marks M, Filer A, Buckley CD, Orozco G, Distler O, Morris AP, Martin P, Eyre S, Ospelt C. Genome Biol. 2021 Aug 25;22(1):247. doi: 10.1186/s13059-021-02460-6. PubMed |
| Quantification of microRNA editing using two-tailed RT-qPCR for improved biomarker discovery. Voss G, Edsjo A, Bjartell A, Ceder Y. RNA. 2021 Nov;27(11):1412-1424. doi: 10.1261/rna.078867.121. Epub 2021 Aug 25. PubMed |
| Predicting base editing outcomes with an attention-based deep learning algorithm trained on high-throughput target library screens. Marquart KF, Allam A, Janjuha S, Sintsova A, Villiger L, Frey N, Krauthammer M, Schwank G. Nat Commun. 2021 Aug 25;12(1):5114. doi: 10.1038/s41467-021-25375-z. PubMed |
| NDST3 deacetylates alpha-tubulin and suppresses V-ATPase assembly and lysosomal acidification. Tang Q, Liu M, Liu Y, Hwang RD, Zhang T, Wang J. EMBO J. 2021 Oct 1;40(19):e107204. doi: 10.15252/embj.2020107204. Epub 2021 Aug 25. PubMed |
| Disruption of RING and PHD Domains of TRIM28 Evokes Differentiation in Human iPSCs. Mazurek S, Oleksiewicz U, Czerwinska P, Wroblewska J, Klimczak M, Wiznerowicz M. Cells. 2021 Jul 29;10(8). pii: cells10081933. doi: 10.3390/cells10081933. PubMed |
| A TALE/HOX code unlocks WNT signalling response towards paraxial mesoderm. Mariani L, Guo X, Menezes NA, Drozd AM, Cakal SD, Wang Q, Ferretti E. Nat Commun. 2021 Aug 26;12(1):5136. doi: 10.1038/s41467-021-25370-4. PubMed |
Application of prime editing to the correction of mutations and phenotypes in adult mice with liver and eye diseases.
Jang H, Jo DH, Cho CS, Shin JH, Seo JH, Yu G, Gopalappa R, Kim D, Cho SR, Kim JH, Kim HH.
Nat Biomed Eng. 2021 Aug 26. pii: 10.1038/s41551-021-00788-9. doi: 10.1038/s41551-021-00788-9.
PubMed
Associated Plasmids |
Direct observation of aggregate-triggered selective autophagy in human cells.
Janssen AFJ, Korsten G, Nijenhuis W, Katrukha EA, Kapitein LC.
J Cell Sci. 2021 Oct 1;134(19). pii: 271972. doi: 10.1242/jcs.258824. Epub 2021 Oct 6.
PubMed
Associated Plasmids |
| Nanog, in Cooperation with AP1, Increases the Expression of E6/E7 Oncogenes from HPV Types 16/18. Diaz-Tejeda Y, Guido-Jimenez MC, Lopez-Carbajal H, Amador-Molina A, Mendez-Martinez R, Gariglio-Vidal P, Lizano M, Garcia-Carranca A. Viruses. 2021 Jul 28;13(8). pii: v13081482. doi: 10.3390/v13081482. PubMed |
| A Genome-Wide CRISPR/Cas9 Screen Reveals the Requirement of Host Sphingomyelin Synthase 1 for Infection with Pseudorabies Virus Mutant gD(-)Pass. Holper JE, Grey F, Baillie JK, Regan T, Parkinson NJ, Hoper D, Thamamongood T, Schwemmle M, Pannhorst K, Wendt L, Mettenleiter TC, Klupp BG. Viruses. 2021 Aug 9;13(8). pii: v13081574. doi: 10.3390/v13081574. PubMed |
| A Novel Frameshifting Inhibitor Having Antiviral Activity against Zoonotic Coronaviruses. Ahn DG, Yoon GY, Lee S, Ku KB, Kim C, Kim KD, Kwon YC, Kim GW, Kim BT, Kim SJ. Viruses. 2021 Aug 18;13(8). pii: v13081639. doi: 10.3390/v13081639. PubMed |
| Uncovering cancer vulnerabilities by machine learning prediction of synthetic lethality. Benfatto S, Sercin O, Dejure FR, Abdollahi A, Zenke FT, Mardin BR. Mol Cancer. 2021 Aug 28;20(1):111. doi: 10.1186/s12943-021-01405-8. PubMed |
| miR-200c-141 Enhances Sheep Kidney Cell Reprogramming into Pluripotent Cells by Targeting ZEB1. Zhang Y, He Y, Wu P, Hu S, Zhang Y, Chen C. Int J Stem Cells. 2021 Nov 30;14(4):423-433. doi: 10.15283/ijsc21080. PubMed |
| Epigallocatechin gallate from green tea effectively blocks infection of SARS-CoV-2 and new variants by inhibiting spike binding to ACE2 receptor. Liu J, Bodnar BH, Meng F, Khan AI, Wang X, Saribas S, Wang T, Lohani SC, Wang P, Wei Z, Luo J, Zhou L, Wu J, Luo G, Li Q, Hu W, Ho W. Cell Biosci. 2021 Aug 30;11(1):168. doi: 10.1186/s13578-021-00680-8. PubMed |
| Targeting the Atf7ip-Setdb1 Complex Augments Antitumor Immunity by Boosting Tumor Immunogenicity. Hu H, Khodadadi-Jamayran A, Dolgalev I, Cho H, Badri S, Chiriboga LA, Zeck B, Lopez De Rodas Gregorio M, Dowling CM, Labbe K, Deng J, Chen T, Zhang H, Zappile P, Chen Z, Ueberheide B, Karatza A, Han H, Ranieri M, Tang S, Jour G, Osman I, Sucker A, Schadendorf D, Tsirigos A, Schalper KA, Velcheti V, Huang HY, Jin Y, Ji H, Poirier JT, Li F, Wong KK. Cancer Immunol Res. 2021 Nov;9(11):1298-1315. doi: 10.1158/2326-6066.CIR-21-0543. Epub 2021 Aug 30. PubMed |
| The Smac mimetic BV6 cooperates with STING to induce necroptosis in apoptosis-resistant pancreatic carcinoma cells. Hannes S, Karlowitz R, van Wijk SJL. Cell Death Dis. 2021 Aug 30;12(9):816. doi: 10.1038/s41419-021-04014-x. PubMed |
Visualizing looping of two endogenous genomic loci using synthetic zinc-finger proteins with anti-FLAG and anti-HA frankenbodies in living cells.
Liu Y, Zhao N, Kanemaki MT, Yamamoto Y, Sadamura Y, Ito Y, Tokunaga M, Stasevich TJ, Kimura H.
Genes Cells. 2021 Nov;26(11):905-926. doi: 10.1111/gtc.12893. Epub 2021 Sep 20.
PubMed
Associated Plasmids |
| Hypoxia-inducible factor 1-alpha enhances the secretome to rejuvenate adult cardiosphere-derived cells. Saha P, Kim M, Tulshyan A, Guo Y, Mishra R, Li D, Civin CI, Kaushal S, Sharma S. J Thorac Cardiovasc Surg. 2021 Jul 17. pii: S0022-5223(21)01046-1. doi: 10.1016/j.jtcvs.2021.07.015. PubMed |
| Antibody-Drug Conjugate Efficacy in Neuroblastoma: Role of Payload, Resistance Mechanisms, Target Density, and Antibody Internalization. Buongervino S, Lane MV, Garrigan E, Zhelev DV, Dimitrov DS, Bosse KR. Mol Cancer Ther. 2021 Nov;20(11):2228-2239. doi: 10.1158/1535-7163.MCT-20-1034. Epub 2021 Aug 31. PubMed |
| Acquisition of aneuploidy drives mutant p53-associated gain-of-function phenotypes. Redman-Rivera LN, Shaver TM, Jin H, Marshall CB, Schafer JM, Sheng Q, Hongo RA, Beckermann KE, Wheeler FC, Lehmann BD, Pietenpol JA. Nat Commun. 2021 Aug 31;12(1):5184. doi: 10.1038/s41467-021-25359-z. PubMed |
| Targeted T cell receptor gene editing provides predictable T cell product function for immunotherapy. Muller TR, Jarosch S, Hammel M, Leube J, Grassmann S, Bernard B, Effenberger M, Andra I, Chaudhry MZ, Kauferle T, Malo A, Cicin-Sain L, Steinberger P, Feuchtinger T, Protzer U, Schumann K, Neuenhahn M, Schober K, Busch DH. Cell Rep Med. 2021 Aug 17;2(8):100374. doi: 10.1016/j.xcrm.2021.100374. eCollection 2021 Aug 17. PubMed |
| Targeted disruption of GAK stagnates autophagic flux by disturbing lysosomal dynamics. Miyazaki M, Hiramoto M, Takano N, Kokuba H, Takemura J, Tokuhisa M, Hino H, Kazama H, Miyazawa K. Int J Mol Med. 2021 Oct;48(4). pii: 195. doi: 10.3892/ijmm.2021.5028. Epub 2021 Sep 1. PubMed |
Discovery of synthetic lethal and tumor suppressor paralog pairs in the human genome.
Parrish PCR, Thomas JD, Gabel AM, Kamlapurkar S, Bradley RK, Berger AH.
Cell Rep. 2021 Aug 31;36(9):109597. doi: 10.1016/j.celrep.2021.109597.
PubMed
Associated Plasmids |
| A NSD3-targeted PROTAC suppresses NSD3 and cMyc oncogenic nodes in cancer cells. Xu C, Meng F, Park KS, Storey AJ, Gong W, Tsai YH, Gibson E, Byrum SD, Li D, Edmondson RD, Mackintosh SG, Vedadi M, Cai L, Tackett AJ, Kaniskan HU, Jin J, Wang GG. Cell Chem Biol. 2022 Mar 17;29(3):386-397.e9. doi: 10.1016/j.chembiol.2021.08.004. Epub 2021 Aug 31. PubMed |
| Cellular model system to dissect the isoform-selectivity of Akt inhibitors. Quambusch L, Depta L, Landel I, Lubeck M, Kirschner T, Nabert J, Uhlenbrock N, Weisner J, Kostka M, Levy LM, Schultz-Fademrecht C, Glanemann F, Althoff K, Muller MP, Siveke JT, Rauh D. Nat Commun. 2021 Sep 6;12(1):5297. doi: 10.1038/s41467-021-25512-8. PubMed |
| Targeting the IRE1alpha/XBP1s pathway suppresses CARM1-expressing ovarian cancer. Lin J, Liu H, Fukumoto T, Zundell J, Yan Q, Tang CA, Wu S, Zhou W, Guo D, Karakashev S, Hu CA, Sarma K, Kossenkov AV, Zhang R. Nat Commun. 2021 Sep 7;12(1):5321. doi: 10.1038/s41467-021-25684-3. PubMed |
| Cytosolic delivery of CDK4/6 inhibitor p16 protein using engineered protein crystals for cancer therapy. Yang Z, Yang M, Chow HM, Tsang SY, Lee MM, Chan MK. Acta Biomater. 2021 Nov;135:582-592. doi: 10.1016/j.actbio.2021.08.054. Epub 2021 Sep 5. PubMed |
| ZFP36L2 Role in Thyroid Functionality. Albano F, Tucci V, Blackshear PJ, Reale C, Roberto L, Russo F, Marotta P, Porreca I, Colella M, Mallardo M, de Felice M, Ambrosino C. Int J Mol Sci. 2021 Aug 29;22(17). pii: ijms22179379. doi: 10.3390/ijms22179379. PubMed |
| SHP2 as a Potential Therapeutic Target in Diffuse-Type Gastric Carcinoma Addicted to Receptor Tyrosine Kinase Signaling. Nagamura Y, Miyazaki M, Nagano Y, Tomiyama A, Ohki R, Yanagihara K, Sakai R, Yamaguchi H. Cancers (Basel). 2021 Aug 26;13(17). pii: cancers13174309. doi: 10.3390/cancers13174309. PubMed |
| Regulation and role of glycophagy in skeletal muscle energy metabolism. Heden TD, Chow LS, Hughey CC, Mashek DG. Autophagy. 2021 Sep 10:1-12. doi: 10.1080/15548627.2021.1969633. PubMed |
| Viral Manipulation of a Mechanoresponsive Signaling Axis Disassembles Processing Bodies. Castle EL, Robinson CA, Douglas P, Rinker KD, Corcoran JA. Mol Cell Biol. 2021 Oct 26;41(11):e0039921. doi: 10.1128/MCB.00399-21. Epub 2021 Sep 13. PubMed |
| Virus-induced senescence is a driver and therapeutic target in COVID-19. Lee S, Yu Y, Trimpert J, Benthani F, Mairhofer M, Richter-Pechanska P, Wyler E, Belenki D, Kaltenbrunner S, Pammer M, Kausche L, Firsching TC, Dietert K, Schotsaert M, Martinez-Romero C, Singh G, Kunz S, Niemeyer D, Ghanem R, Salzer HJF, Paar C, Mulleder M, Uccellini M, Michaelis EG, Khan A, Lau A, Schonlein M, Habringer A, Tomasits J, Adler JM, Kimeswenger S, Gruber AD, Hoetzenecker W, Steinkellner H, Purfurst B, Motz R, Di Pierro F, Lamprecht B, Osterrieder N, Landthaler M, Drosten C, Garcia-Sastre A, Langer R, Ralser M, Eils R, Reimann M, Fan DNY, Schmitt CA. Nature. 2021 Nov;599(7884):283-289. doi: 10.1038/s41586-021-03995-1. Epub 2021 Sep 13. PubMed |
| MEF2D-NR4A1-FAM134B2-mediated reticulophagy contributes to amino acid homeostasis. Shiozaki Y, Miyazaki-Anzai S, Keenan AL, Miyazaki M. Autophagy. 2021 Sep 14:1-13. doi: 10.1080/15548627.2021.1968228. PubMed |
| Therapeutic inhibition of USP9x-mediated Notch signaling in triple-negative breast cancer. Jaiswal A, Murakami K, Elia A, Shibahara Y, Done SJ, Wood SA, Donato NJ, Ohashi PS, Reedijk M. Proc Natl Acad Sci U S A. 2021 Sep 21;118(38). pii: 2101592118. doi: 10.1073/pnas.2101592118. PubMed |
Intrinsically disordered protein biosensor tracks the physical-chemical effects of osmotic stress on cells.
Cuevas-Velazquez CL, Vellosillo T, Guadalupe K, Schmidt HB, Yu F, Moses D, Brophy JAN, Cosio-Acosta D, Das A, Wang L, Jones AM, Covarrubias AA, Sukenik S, Dinneny JR.
Nat Commun. 2021 Sep 14;12(1):5438. doi: 10.1038/s41467-021-25736-8.
PubMed
Associated Plasmids |
| An active tethering mechanism controls the fate of vesicles. An SJ, Rivera-Molina F, Anneken A, Xi Z, McNellis B, Polejaev VI, Toomre D. Nat Commun. 2021 Sep 14;12(1):5434. doi: 10.1038/s41467-021-25465-y. PubMed |
| Therapeutic targeting of the PLK1-PRC1-axis triggers cell death in genomically silent childhood cancer. Li J, Ohmura S, Marchetto A, Orth MF, Imle R, Dallmayer M, Musa J, Knott MML, Holting TLB, Stein S, Funk CM, Sastre A, Alonso J, Bestvater F, Kasan M, Romero-Perez L, Hartmann W, Ranft A, Banito A, Dirksen U, Kirchner T, Cidre-Aranaz F, Grunewald TGP. Nat Commun. 2021 Sep 16;12(1):5356. doi: 10.1038/s41467-021-25553-z. PubMed |
| Generation of stable cell lines using readthrough expression from lentiviral integration. Jadav A, Truong K. Biotechnol Lett. 2021 Nov;43(11):2131-2136. doi: 10.1007/s10529-021-03186-y. Epub 2021 Sep 17. PubMed |
| Efficient Generation of Multi-gene Knockout Cell Lines and Patient-derived Xenografts Using Multi-colored Lenti-CRISPR-Cas9. Behrmann L, McComb S, Aguade-Gorgorio J, Huang Y, Hermann M, Pelczar P, Aguzzi A, Bourquin JP, Bornhauser BC. Bio Protoc. 2017 Apr 5;7(7):e2222. doi: 10.21769/BioProtoc.2222. eCollection 2017 Apr 5. PubMed |
| Critical Evaluation of Different Lysosomal Labeling Methods Used to Analyze RNA Nanocarrier Trafficking in Cells. Iqbal S, Luo B, Melamed JR, Day ES. Bioconjug Chem. 2021 Oct 20;32(10):2245-2256. doi: 10.1021/acs.bioconjchem.1c00405. Epub 2021 Sep 20. PubMed |
| The HTLV-1 viral oncoproteins Tax and HBZ reprogram the cellular mRNA splicing landscape. Vandermeulen C, O'Grady T, Wayet J, Galvan B, Maseko S, Cherkaoui M, Desbuleux A, Coppin G, Olivet J, Ben Ameur L, Kataoka K, Ogawa S, Hermine O, Marcais A, Thiry M, Mortreux F, Calderwood MA, Van Weyenbergh J, Peloponese JM, Charloteaux B, Van den Broeke A, Hill DE, Vidal M, Dequiedt F, Twizere JC. PLoS Pathog. 2021 Sep 20;17(9):e1009919. doi: 10.1371/journal.ppat.1009919. eCollection 2021 Sep. PubMed |
| PCV2 targets cGAS to inhibit type I interferon induction to promote other DNA virus infection. Wang Z, Chen J, Wu X, Ma D, Zhang X, Li R, Han C, Liu H, Yin X, Du Q, Tong D, Huang Y. PLoS Pathog. 2021 Sep 20;17(9):e1009940. doi: 10.1371/journal.ppat.1009940. eCollection 2021 Sep. PubMed |
| ATF4-mediated transcriptional regulation protects against beta-cell loss during endoplasmic reticulum stress in a mouse model. Kitakaze K, Oyadomari M, Zhang J, Hamada Y, Takenouchi Y, Tsuboi K, Inagaki M, Tachikawa M, Fujitani Y, Okamoto Y, Oyadomari S. Mol Metab. 2021 Dec;54:101338. doi: 10.1016/j.molmet.2021.101338. Epub 2021 Sep 20. PubMed |
| Acute and chronic effects of a light-activated FGF receptor in keratinocytes in vitro and in mice. Rauschendorfer T, Gurri S, Heggli I, Maddaluno L, Meyer M, Ingles-Prieto A, Janovjak H, Werner S. Life Sci Alliance. 2021 Sep 21;4(11). pii: 4/11/e202101100. doi: 10.26508/lsa.202101100. Print 2021 Nov. PubMed |
| Epicardial differentiation drives fibro-fatty remodeling in arrhythmogenic cardiomyopathy. Kohela A, van Kampen SJ, Moens T, Wehrens M, Molenaar B, Boogerd CJ, Monshouwer-Kloots J, Perini I, Goumans MJ, Smits AM, van Tintelen JP, van Rooij E. Sci Transl Med. 2021 Sep 22;13(612):eabf2750. doi: 10.1126/scitranslmed.abf2750. Epub 2021 Sep 22. PubMed |
| Liquid condensation of reprogramming factor KLF4 with DNA provides a mechanism for chromatin organization. Sharma R, Choi KJ, Quan MD, Sharma S, Sankaran B, Park H, LaGrone A, Kim JJ, MacKenzie KR, Ferreon ACM, Kim C, Ferreon JC. Nat Commun. 2021 Sep 22;12(1):5579. doi: 10.1038/s41467-021-25761-7. PubMed |
| Transposon-triggered innate immune response confers cancer resistance to the blind mole rat. Zhao Y, Oreskovic E, Zhang Q, Lu Q, Gilman A, Lin YS, He J, Zheng Z, Lu JY, Lee J, Ke Z, Ablaeva J, Sweet MJ, Horvath S, Zhang Z, Nevo E, Seluanov A, Gorbunova V. Nat Immunol. 2021 Oct;22(10):1219-1230. doi: 10.1038/s41590-021-01027-8. Epub 2021 Sep 23. PubMed |
| The identification of a shorter cyclic GMP-AMP synthase gene from chickens and bioinformatics analysis of its potential signaling in IFN regulation. Zhu W, Cheng Y, Wang Z, Ji L, Ma J, Yan Y, Wang H, Sun J. Dev Comp Immunol. 2022 Feb;127:104266. doi: 10.1016/j.dci.2021.104266. Epub 2021 Sep 23. PubMed |
| A Co-Culture-Based Multiparametric Imaging Technique to Dissect Local H2O2 Signals with Targeted HyPer7. Secilmis M, Altun HY, Pilic J, Erdogan YC, Cokluk Z, Ata BN, Sevimli G, Zaki AG, Yigit EN, Ozturk G, Malli R, Eroglu E. Biosensors (Basel). 2021 Sep 14;11(9). pii: bios11090338. doi: 10.3390/bios11090338. PubMed |
| A persistent invasive phenotype in post-hypoxic tumor cells is revealed by fate mapping and computational modeling. Rocha HL, Godet I, Kurtoglu F, Metzcar J, Konstantinopoulos K, Bhoyar S, Gilkes DM, Macklin P. iScience. 2021 Aug 4;24(9):102935. doi: 10.1016/j.isci.2021.102935. eCollection 2021 Sep 24. PubMed |
| Monocytic differentiation and AHR signaling as Primary Nodes of BET Inhibitor Response in Acute Myeloid Leukemia. Romine KA, Nechiporuk T, Bottomly D, Jeng S, McWeeney SK, Kaempf A, Corces MR, Majeti R, Tyner JW. Blood Cancer Discov. 2021 Sep;2(5):518-531. doi: 10.1158/2643-3230.BCD-21-0012. Epub 2021 Jul 1. PubMed |
| Assessing the Wnt-reactivity of cytonemes of mouse embryonic stem cells using a bioengineering approach. Junyent S, Reeves J, Habib SJ. STAR Protoc. 2021 Sep 15;2(3):100813. doi: 10.1016/j.xpro.2021.100813. eCollection 2021 Sep 17. PubMed |
| Titan Cells and Yeast Forms of Cryptococcus neoformans and Cryptococcus gattii Are Recognized by GXMR-CAR. Dos Santos MH, Machado MP, Kumaresan PR, da Silva TA. Microorganisms. 2021 Sep 5;9(9). pii: microorganisms9091886. doi: 10.3390/microorganisms9091886. PubMed |
| Efficient Inhibition of HIV Using CRISPR/Cas13d Nuclease System. Nguyen H, Wilson H, Jayakumar S, Kulkarni V, Kulkarni S. Viruses. 2021 Sep 16;13(9). pii: v13091850. doi: 10.3390/v13091850. PubMed |
| Regulatory variants at 2q33.1 confer schizophrenia risk by modulating distal gene TYW5 expression. Li S, Li J, Liu J, Wang J, Li X, Huo Y, Li Y, Liu Y, Li M, Xiao X, Luo XJ. Brain. 2022 Apr 18;145(2):770-786. doi: 10.1093/brain/awab357. PubMed |
| Beta-Pix-dynamin 2 complex promotes colorectal cancer progression by facilitating membrane dynamics. Keum S, Yang SJ, Park E, Kang T, Choi JH, Jeong J, Hwang YE, Kim JW, Park D, Rhee S. Cell Oncol (Dordr). 2021 Dec;44(6):1287-1305. doi: 10.1007/s13402-021-00637-6. Epub 2021 Sep 28. PubMed |
| Instant determination of the artemisinin from various Artemisia annua L. extracts by LC-ESI-MS/MS and their in-silico modelling and in vitro antiviral activity studies against SARS-CoV-2. Dogan K, Erol E, Didem Orhan M, Degirmenci Z, Kan T, Gungor A, Yasa B, Avsar T, Cetin Y, Durdagi S, Guzel M. Phytochem Anal. 2022 Mar;33(2):303-319. doi: 10.1002/pca.3088. Epub 2021 Sep 28. PubMed |
| Dendritic Cell-Specific Role for Pellino2 as a Mediator of TLR9 Signaling Pathway. Oleszycka E, Rodgers AM, Xu L, Moynagh PN. J Immunol. 2021 Nov 1;207(9):2325-2336. doi: 10.4049/jimmunol.2100236. Epub 2021 Sep 29. PubMed |
| Mapping Genetic Interactions in Human Cancer Cells Using a One-Step tRNA-CRISPR System. Zhang DY, Gui X, Yang X. Methods Mol Biol. 2021;2381:175-187. doi: 10.1007/978-1-0716-1740-3_9. PubMed |
| Herpes simplex virus 1 evades cellular antiviral response by inducing microRNA-24, which attenuates STING synthesis. Sharma N, Wang C, Kessler P, Sen GC. PLoS Pathog. 2021 Sep 30;17(9):e1009950. doi: 10.1371/journal.ppat.1009950. eCollection 2021 Sep. PubMed |
| Sphingosine 1-phosphate receptor type 2 positively regulates interleukin (IL)-4/IL-13-induced STAT6 phosphorylation. Okamoto Y, Kitakaze K, Takenouchi Y, Yamamoto S, Ishimaru H, Tsuboi K. Cell Signal. 2021 Dec;88:110156. doi: 10.1016/j.cellsig.2021.110156. Epub 2021 Sep 28. PubMed |
| Unraveling the hidden role of a uORF-encoded peptide as a kinase inhibitor of PKCs. Jayaram DR, Frost S, Argov C, Liju VB, Anto NP, Muraleedharan A, Ben-Ari A, Sinay R, Smoly I, Novoplansky O, Isakov N, Toiber D, Keasar C, Elkabets M, Yeger-Lotem E, Livneh E. Proc Natl Acad Sci U S A. 2021 Oct 5;118(40). pii: 2018899118. doi: 10.1073/pnas.2018899118. Epub 2021 Sep 30. PubMed |
| Development of a DELFIA method to detect oncofetal antigen ROR1-positive exosomes. Daikuzono H, Yamazaki M, Sato Y, Takahashi T, Yamagata K. Biochem Biophys Res Commun. 2021 Nov 12;578:170-176. doi: 10.1016/j.bbrc.2021.08.054. Epub 2021 Aug 24. PubMed |
| A highly potent antibody effective against SARS-CoV-2 variants of concern. Fenwick C, Turelli P, Perez L, Pellaton C, Esteves-Leuenberger L, Farina A, Campos J, Lana E, Fiscalini F, Raclot C, Pojer F, Lau K, Demurtas D, Descatoire M, Joo VS, Foglierini M, Noto A, Abdelnabi R, Foo CS, Vangeel L, Neyts J, Du W, Bosch BJ, Veldman G, Leyssen P, Thiel V, LeGrand R, Levy Y, Trono D, Pantaleo G. Cell Rep. 2021 Oct 12;37(2):109814. doi: 10.1016/j.celrep.2021.109814. Epub 2021 Sep 21. PubMed |
| Overexpression of lncRNAs with endogenous lengths and functions using a lncRNA delivery system based on transposon. Zhang Y, Huang YX, Jin X, Chen J, Peng L, Wang DL, Li Y, Yao XY, Liao JY, He JH, Hu K, Lu D, Guo Y, Yin D. J Nanobiotechnology. 2021 Oct 2;19(1):303. doi: 10.1186/s12951-021-01044-7. PubMed |
| The deubiquitinase USP11 is a versatile and conserved regulator of autophagy. Basic M, Hertel A, Bajdzienko J, Bonn F, Tellechea M, Stolz A, Kern A, Behl C, Bremm A. J Biol Chem. 2021 Nov;297(5):101263. doi: 10.1016/j.jbc.2021.101263. Epub 2021 Sep 30. PubMed |
| Myogenin controls via AKAP6 non-centrosomal microtubule-organizing center formation at the nuclear envelope. Becker R, Vergarajauregui S, Billing F, Sharkova M, Lippolis E, Mamchaoui K, Ferrazzi F, Engel FB. Elife. 2021 Oct 4;10. pii: 65672. doi: 10.7554/eLife.65672. PubMed |
| PHDs/CPT1B/VDAC1 axis regulates long-chain fatty acid oxidation in cardiomyocytes. Angelini A, Saha PK, Jain A, Jung SY, Mynatt RL, Pi X, Xie L. Cell Rep. 2021 Oct 5;37(1):109767. doi: 10.1016/j.celrep.2021.109767. PubMed |
| NEDD8-activating enzyme inhibition induces cell cycle arrest and anaphase catastrophe in malignant T-cells. Kittai AS, Danilova OV, Lam V, Liu T, Bruss N, Best S, Fan G, Danilov AV. Oncotarget. 2021 Sep 28;12(20):2068-2074. doi: 10.18632/oncotarget.28063. eCollection 2021 Sep 28. PubMed |
| A Simple, Rapid, and Cost-Effective Method for Loss-of-Function Assays in Pluripotent Cells. Covelo-Molares H, Souto Y, Fidalgo M, Guallar D. Methods Mol Biol. 2021 Oct 6. doi: 10.1007/7651_2021_434. PubMed |
A functional genetic toolbox for human tissue-derived organoids.
Sun D, Evans L, Perrone F, Sokleva V, Lim K, Rezakhani S, Lutolf M, Zilbauer M, Rawlins EL.
eLife. 2021 Oct 6;10. pii: 67886. doi: 10.7554/eLife.67886.
PubMed
Associated Plasmids |
| Zika Virus Requires the Expression of Claudin-7 for Optimal Replication in Human Endothelial Cells. Zoladek J, Legros V, Jeannin P, Chazal M, Pardigon N, Ceccaldi PE, Gessain A, Jouvenet N, Afonso PV. Front Microbiol. 2021 Sep 20;12:746589. doi: 10.3389/fmicb.2021.746589. eCollection 2021. PubMed |
| Cochlear Sox2(+) Glial Cells Are Potent Progenitors for Spiral Ganglion Neuron Reprogramming Induced by Small Molecules. Chen Z, Huang Y, Yu C, Liu Q, Qiu C, Wan G. Front Cell Dev Biol. 2021 Sep 21;9:728352. doi: 10.3389/fcell.2021.728352. eCollection 2021. PubMed |
| CCNE1 copy number is a biomarker for response to combination WEE1-ATR inhibition in ovarian and endometrial cancer models. Xu H, George E, Kinose Y, Kim H, Shah JB, Peake JD, Ferman B, Medvedev S, Murtha T, Barger CJ, Devins KM, D'Andrea K, Wubbenhorst B, Schwartz LE, Hwang WT, Mills GB, Nathanson KL, Karpf AR, Drapkin R, Brown EJ, Simpkins F. Cell Rep Med. 2021 Sep 23;2(9):100394. doi: 10.1016/j.xcrm.2021.100394. eCollection 2021 Sep 21. PubMed |
| Labeling and measuring stressed mitochondria using a PINK1-based ratiometric fluorescent sensor. Uesugi R, Ishii S, Matsuura A, Itakura E. J Biol Chem. 2021 Nov;297(5):101279. doi: 10.1016/j.jbc.2021.101279. Epub 2021 Oct 5. PubMed |
| Low-density-lipoprotein-receptor-related protein 1 mediates Notch pathway activation. Bian W, Tang M, Jiang H, Xu W, Hao W, Sui Y, Hou Y, Nie L, Zhang H, Wang C, Li N, Wang J, Qin J, Wu L, Ma X, Chen J, Wang W, Li X. Dev Cell. 2021 Oct 25;56(20):2902-2919.e8. doi: 10.1016/j.devcel.2021.09.015. Epub 2021 Oct 8. PubMed |
| hnRNPA2B1 Promotes Colon Cancer Progression via the MAPK Pathway. Tang J, Chen Z, Wang Q, Hao W, Gao WQ, Xu H. Front Genet. 2021 Sep 22;12:666451. doi: 10.3389/fgene.2021.666451. eCollection 2021. PubMed |
Replacing the SpCas9 HNH domain by deaminases generates compact base editors with an alternative targeting scope.
Villiger L, Schmidheini L, Mathis N, Rothgangl T, Marquart K, Schwank G.
Mol Ther Nucleic Acids. 2021 Aug 26;26:502-510. doi: 10.1016/j.omtn.2021.08.025. eCollection 2021 Dec 3.
PubMed
Associated Plasmids |
| Sulfation of glycosaminoglycans depends on the catalytic activity of lithium-inhibited phosphatase BPNT2 in vitro. Eisele BS, Luka Z, Wu AJ, Yang F, Hale AT, York JD. J Biol Chem. 2021 Nov;297(5):101293. doi: 10.1016/j.jbc.2021.101293. Epub 2021 Oct 8. PubMed |
| TEC kinase stabilizes PLK4 to promote liver cancer metastasis. Yeung SF, Zhou Y, Zou W, Chan WL, Ching YP. Cancer Lett. 2022 Jan 1;524:70-81. doi: 10.1016/j.canlet.2021.08.038. Epub 2021 Oct 9. PubMed |
| Transcription Factor RBPJL Is Able to Repress Notch Target Gene Expression but Is Non-Responsive to Notch Activation. Pan L, Hoffmeister P, Turkiewicz A, Huynh NND, Grosse-Berkenbusch A, Knippschild U, Gebhardt JCM, Baumann B, Borggrefe T, Oswald F. Cancers (Basel). 2021 Oct 8;13(19). pii: cancers13195027. doi: 10.3390/cancers13195027. PubMed |
| Cooperative methylation of human tRNA3Lys at positions A58 and U54 drives the early and late steps of HIV-1 replication. Fukuda H, Chujo T, Wei FY, Shi SL, Hirayama M, Kaitsuka T, Yamamoto T, Oshiumi H, Tomizawa K. Nucleic Acids Res. 2021 Nov 18;49(20):11855-11867. doi: 10.1093/nar/gkab879. PubMed |
| Specific Activation of the CD271 Intracellular Domain in Combination with Chemotherapy or Targeted Therapy Inhibits Melanoma Progression. Saltari A, Dzung A, Quadri M, Tiso N, Facchinello N, Hernandez-Barranco A, Garcia-Silva S, Nogues L, Stoffel CI, Cheng PF, Turko P, Eichhoff OM, Truzzi F, Marconi A, Pincelli C, Peinado H, Dummer R, Levesque MP. Cancer Res. 2021 Dec 1;81(23):6044-6057. doi: 10.1158/0008-5472.CAN-21-0117. Epub 2021 Oct 13. PubMed |
| Circular RNA circIPO11 drives self-renewal of liver cancer initiating cells via Hedgehog signaling. Gu Y, Wang Y, He L, Zhang J, Zhu X, Liu N, Wang J, Lu T, He L, Tian Y, Fan Z. Mol Cancer. 2021 Oct 14;20(1):132. doi: 10.1186/s12943-021-01435-2. PubMed |
Plexin-B2 orchestrates collective stem cell dynamics via actomyosin contractility, cytoskeletal tension and adhesion.
Junqueira Alves C, Dariolli R, Haydak J, Kang S, Hannah T, Wiener RJ, DeFronzo S, Tejero R, Gusella GL, Ramakrishnan A, Alves Dias R, Wojcinski A, Kesari S, Shen L, Sobie EA, Rodrigues Furtado de Mendonca JP, Azeloglu EU, Zou H, Friedel RH.
Nat Commun. 2021 Oct 14;12(1):6019. doi: 10.1038/s41467-021-26296-7.
PubMed
Associated Plasmids |
| Antiviral Potential of the Antimicrobial Drug Atovaquone against SARS-CoV-2 and Emerging Variants of Concern. Carter-Timofte ME, Arulanandam R, Kurmasheva N, Fu K, Laroche G, Taha Z, van der Horst D, Cassin L, van der Sluis RM, Palermo E, Di Carlo D, Jacobs D, Maznyi G, Azad T, Singaravelu R, Ren F, Hansen AL, Idorn M, Holm CK, Jakobsen MR, van Grevenynghe J, Hiscott J, Paludan SR, Bell JC, Seguin J, Sabourin LA, Cote M, Diallo JS, Alain T, Olagnier D. ACS Infect Dis. 2021 Nov 12;7(11):3034-3051. doi: 10.1021/acsinfecdis.1c00278. Epub 2021 Oct 18. PubMed |
| RNA-binding Protein MBNL2 regulates Cancer Cell Metastasis through MiR-182-MBNL2-AKT Pathway. Lin G, Li J, Cai J, Zhang H, Xin Q, Wang N, Xie W, Zhang Y, Xu N. J Cancer. 2021 Sep 21;12(22):6715-6726. doi: 10.7150/jca.62816. eCollection 2021. PubMed |
| Inhibition of CBP synergizes with the RNA-dependent mechanisms of Azacitidine by limiting protein synthesis. Diesch J, Le Pannerer MM, Winkler R, Casquero R, Muhar M, van der Garde M, Maher M, Herraez CM, Bech-Serra JJ, Fellner M, Rathert P, Brooks N, Zamora L, Gentilella A, de la Torre C, Zuber J, Gotze KS, Buschbeck M. Nat Commun. 2021 Oct 18;12(1):6060. doi: 10.1038/s41467-021-26258-z. PubMed |
| Human Erbb2-induced Erk activity robustly stimulates cycling and functional remodeling of rat and human cardiomyocytes. Strash N, DeLuca S, Janer Carattini GL, Heo SC, Gorsuch R, Bursac N. Elife. 2021 Oct 19;10. pii: 65512. doi: 10.7554/eLife.65512. PubMed |
| Translational repression of NMD targets by GIGYF2 and EIF4E2. Zinshteyn B, Sinha NK, Enam SU, Koleske B, Green R. PLoS Genet. 2021 Oct 19;17(10):e1009813. doi: 10.1371/journal.pgen.1009813. eCollection 2021 Oct. PubMed |
| YAP inhibition promotes endothelial cell differentiation from pluripotent stem cell through EC master transcription factor FLI1. Quan Y, Shan X, Hu M, Jin P, Ma J, Fan J, Yang J, Zhang H, Fan X, Gong Y, Li M, Wang Y. J Mol Cell Cardiol. 2022 Feb;163:81-96. doi: 10.1016/j.yjmcc.2021.10.004. Epub 2021 Oct 16. PubMed |
Redundant roles of EGFR ligands in the ERK activation waves during collective cell migration.
Lin S, Hirayama D, Maryu G, Matsuda K, Hino N, Deguchi E, Aoki K, Iwamoto R, Terai K, Matsuda M.
Life Sci Alliance. 2021 Oct 19;5(1). pii: 5/1/e202101206. doi: 10.26508/lsa.202101206. Print 2022 Jan.
PubMed
Associated Plasmids |
| Retinoic acid rewires the adrenergic core regulatory circuitry of childhood neuroblastoma. Zimmerman MW, Durbin AD, He S, Oppel F, Shi H, Tao T, Li Z, Berezovskaya A, Liu Y, Zhang J, Young RA, Abraham BJ, Look AT. Sci Adv. 2021 Oct 22;7(43):eabe0834. doi: 10.1126/sciadv.abe0834. Epub 2021 Oct 20. PubMed |
| N(6) -Methyladenosine Negatively Regulates Human Respiratory Syncytial Virus Replication. Figueroa F, Vega-Gibson A, Catrileo J, Gaete-Argel A, Riquelme-Barrios S, Alonso-Palomares LA, Tapia LI, Valiente-Echeverria F, Soto-Rifo R, Acevedo ML. Front Cell Dev Biol. 2021 Oct 4;9:739445. doi: 10.3389/fcell.2021.739445. eCollection 2021. PubMed |
| Development of a selective fluorescence-based enzyme assay for glycerophosphodiesterase family members GDE4 and GDE7. Kitakaze K, Tsuboi K, Tsuda M, Takenouchi Y, Ishimaru H, Okamoto Y. J Lipid Res. 2021;62:100141. doi: 10.1016/j.jlr.2021.100141. Epub 2021 Oct 18. PubMed |
| Steroid sulfatase deficiency causes cellular senescence and abnormal differentiation by inducing Yippee-like 3 expression in human keratinocytes. Baek HS, Kwon TU, Shin S, Kwon YJ, Chun YJ. Sci Rep. 2021 Oct 21;11(1):20867. doi: 10.1038/s41598-021-00051-w. PubMed |
| Traf2 and NCK Interacting Kinase Is a Critical Regulator of Procollagen I Trafficking and Hepatic Fibrogenesis in Mice. Buchl SC, Hanquier Z, Haak AJ, Thomason YM, Huebert RC, Shah VH, Maiers JL. Hepatol Commun. 2022 Mar;6(3):593-609. doi: 10.1002/hep4.1835. Epub 2021 Oct 22. PubMed |
| Osteocalcin attenuates oligodendrocyte differentiation and myelination via GPR37 signaling in the mouse brain. Qian Z, Li H, Yang H, Yang Q, Lu Z, Wang L, Chen Y, Li X. Sci Adv. 2021 Oct 22;7(43):eabi5811. doi: 10.1126/sciadv.abi5811. Epub 2021 Oct 22. PubMed |
| The neutralization effect of montelukast on SARS-CoV-2 is shown by multiscale in silico simulations and combined in vitro studies. Durdagi S, Avsar T, Orhan MD, Serhatli M, Balcioglu BK, Ozturk HU, Kayabolen A, Cetin Y, Aydinlik S, Bagci-Onder T, Tekin S, Demirci H, Guzel M, Akdemir A, Calis S, Oktay L, Tolu I, Butun YE, Erdemoglu E, Olkan A, Tokay N, Isik S, Ozcan A, Acar E, Buyukkilic S, Yumak Y. Mol Ther. 2022 Feb 2;30(2):963-974. doi: 10.1016/j.ymthe.2021.10.014. Epub 2021 Oct 19. PubMed |
| CRISPR activation of endogenous genes reprograms fibroblasts into cardiovascular progenitor cells for myocardial infarction therapy. Jiang L, Liang J, Huang W, Ma J, Park KH, Wu Z, Chen P, Zhu H, Ma JJ, Cai W, Paul C, Niu L, Fan GC, Wang HS, Kanisicak O, Xu M, Wang Y. Mol Ther. 2022 Jan 5;30(1):54-74. doi: 10.1016/j.ymthe.2021.10.015. Epub 2021 Oct 20. PubMed |
| Deficiency of the Lysosomal Protein CLN5 Alters Lysosomal Function and Movement. Basak I, Hansen RA, Ward ME, Hughes SM. Biomolecules. 2021 Sep 27;11(10). pii: biom11101412. doi: 10.3390/biom11101412. PubMed |
| miR-221/222 suppression induced by activation of the cAMP/PKA/CREB1 pathway is required for cAMP-induced bidirectional differentiation of glioma cells. Liu Q, Tian R, Yu P, Shu M. FEBS Lett. 2021 Nov;595(22):2829-2843. doi: 10.1002/1873-3468.14208. Epub 2021 Oct 27. PubMed |
| Effective chimeric antigen receptor T cells against SARS-CoV-2. Guo X, Kazanova A, Thurmond S, Saragovi HU, Rudd CE. iScience. 2021 Nov 19;24(11):103295. doi: 10.1016/j.isci.2021.103295. Epub 2021 Oct 16. PubMed |
| FCRL1 Regulates B Cell Receptor-Induced ERK Activation through GRB2. DeLuca JM, Murphy MK, Wang X, Wilson TJ. J Immunol. 2021 Dec 1;207(11):2688-2698. doi: 10.4049/jimmunol.2100218. Epub 2021 Oct 25. PubMed |
| Single-stranded DNA binding proteins influence APOBEC3A substrate preference. Brown AL, Collins CD, Thompson S, Coxon M, Mertz TM, Roberts SA. Sci Rep. 2021 Oct 25;11(1):21008. doi: 10.1038/s41598-021-00435-y. PubMed |
| Dnmt3a-mutated clonal hematopoiesis promotes osteoporosis. Kim PG, Niroula A, Shkolnik V, McConkey M, Lin AE, Slabicki M, Kemp JP, Bick A, Gibson CJ, Griffin G, Sekar A, Brooks DJ, Wong WJ, Cohen DN, Uddin MM, Shin WJ, Pirruccello J, Tsai JM, Agrawal M, Kiel DP, Bouxsein ML, Richards JB, Evans DM, Wein MN, Charles JF, Jaiswal S, Natarajan P, Ebert BL. J Exp Med. 2021 Dec 6;218(12). pii: 212724. doi: 10.1084/jem.20211872. Epub 2021 Oct 26. PubMed |
| Non-targeting control for MISSION shRNA library silences SNRPD3 leading to cell death or permanent growth arrest. Czarnek M, Sarad K, Karas A, Kochan J, Bereta J. Mol Ther Nucleic Acids. 2021 Sep 15;26:711-731. doi: 10.1016/j.omtn.2021.09.004. eCollection 2021 Dec 3. PubMed |
| Establishment of a pig CRISPR/Cas9 knockout library for functional gene screening in pig cells. Yu C, Zhong H, Yang X, Li G, Wu Z, Yang H. Biotechnol J. 2021 Oct 27:e2100408. doi: 10.1002/biot.202100408. PubMed |
| Defining the fetal origin of MLL-AF4 infant leukemia highlights specific fatty acid requirements. Symeonidou V, Jakobczyk H, Bashanfer S, Malouf C, Fotopoulou F, Kotecha RS, Anderson RA, Finch AJ, Ottersbach K. Cell Rep. 2021 Oct 26;37(4):109900. doi: 10.1016/j.celrep.2021.109900. PubMed |
| GCN2 adapts protein synthesis to scavenging-dependent growth. Nofal M, Wang T, Yang L, Jankowski CSR, Hsin-Jung Li S, Han S, Parsons L, Frese AN, Gitai Z, Anthony TG, Wuhr M, Sabatini DM, Rabinowitz JD. Cell Syst. 2022 Feb 16;13(2):158-172.e9. doi: 10.1016/j.cels.2021.09.014. Epub 2021 Oct 26. PubMed |
| Target Identification of Small Molecules Using Large-Scale CRISPR-Cas Mutagenesis Scanning of Essential Genes. Kwanten B, Neggers JE, Daelemans D. Methods Mol Biol. 2022;2377:43-67. doi: 10.1007/978-1-0716-1720-5_3. PubMed |
| RNA-responsive elements for eukaryotic translational control. Zhao EM, Mao AS, de Puig H, Zhang K, Tippens ND, Tan X, Ran FA, Han I, Nguyen PQ, Chory EJ, Hua TY, Ramesh P, Thompson DB, Oh CY, Zigon ES, English MA, Collins JJ. Nat Biotechnol. 2022 Apr;40(4):539-545. doi: 10.1038/s41587-021-01068-2. Epub 2021 Oct 28. PubMed |
| MI-773, a breaker of the MDM2/p53 axis, exhibits anticancer effects in neuroblastoma via downregulation of INSM1. Chen YL, Zhang ZM, Li XL, Tao YF, Wu SY, Fang F, Xie Y, Liao XM, Li G, Wu D, Wang HR, Zuo R, Cao HB, Pan JJ, Yu JJ, Zhang Z, Chu XR, Zhang YP, Feng CX, Wang JW, Lu J, Hu SY, Li ZH, Pan J. Oncol Lett. 2021 Dec;22(6):838. doi: 10.3892/ol.2021.13099. Epub 2021 Oct 18. PubMed |
| MiRNA-146a/AKT/beta-Catenin Activation Regulates Cancer Stem Cell Phenotype in Oral Squamous Cell Carcinoma by Targeting CD24. Ghuwalewala S, Ghatak D, Das S, Roy S, Das P, Butti R, Gorain M, Nath S, Kundu GC, Roychoudhury S. Front Oncol. 2021 Oct 12;11:651692. doi: 10.3389/fonc.2021.651692. eCollection 2021. PubMed |
| FACS-based protocol to assess cytotoxicity and clonogenic potential of colorectal cancer stem cells using a Wnt/beta-catenin signaling pathway reporter. Di Franco S, Zhang L, Gaggianesi M, Lo Iacono M, Medema JP, Stassi G. STAR Protoc. 2021 Oct 19;2(4):100880. doi: 10.1016/j.xpro.2021.100880. eCollection 2021 Dec 17. PubMed |
| Genetic, cellular, and structural characterization of the membrane potential-dependent cell-penetrating peptide translocation pore. Trofimenko E, Grasso G, Heulot M, Chevalier N, Deriu MA, Dubuis G, Arribat Y, Serulla M, Michel S, Vantomme G, Ory F, Dam LC, Puyal J, Amati F, Luthi A, Danani A, Widmann C. Elife. 2021 Oct 29;10. pii: 69832. doi: 10.7554/eLife.69832. PubMed |
| CHRAC1 promotes human lung cancer growth through regulating YAP transcriptional activity. Wang M, Li S, Guo W, Wang L, Huang J, Zhuo J, Lai B, Liao C, Ge T, Nie Y, Jin S, Wang M, Zhang Y, Liu Y, Li X, Zhang H. Carcinogenesis. 2022 Apr 25;43(3):264-276. doi: 10.1093/carcin/bgab103. PubMed |
| Control of osteocyte dendrite formation by Sp7 and its target gene osteocrin. Wang JS, Kamath T, Mazur CM, Mirzamohammadi F, Rotter D, Hojo H, Castro CD, Tokavanich N, Patel R, Govea N, Enishi T, Wu Y, da Silva Martins J, Bruce M, Brooks DJ, Bouxsein ML, Tokarz D, Lin CP, Abdul A, Macosko EZ, Fiscaletti M, Munns CF, Ryder P, Kost-Alimova M, Byrne P, Cimini B, Fujiwara M, Kronenberg HM, Wein MN. Nat Commun. 2021 Nov 1;12(1):6271. doi: 10.1038/s41467-021-26571-7. PubMed |
| Mitochondrial respiration contributes to the interferon gamma response in antigen-presenting cells. Kiritsy MC, McCann K, Mott D, Holland SM, Behar SM, Sassetti CM, Olive AJ. Elife. 2021 Nov 2;10. pii: 65109. doi: 10.7554/eLife.65109. PubMed |
| Anti-apoptotic MCL1 Protein Represents Critical Survival Molecule for Most Burkitt Lymphomas and BCL2-negative Diffuse Large B-cell Lymphomas. Klanova M, Kazantsev D, Pokorna E, Zikmund T, Karolova J, Behounek M, Renesova N, Sovilj D, Kelemen CD, Helman K, Jaksa R, Havranek O, Andera L, Trneny M, Klener P. Mol Cancer Ther. 2022 Jan;21(1):89-99. doi: 10.1158/1535-7163.MCT-21-0511. Epub 2021 Nov 2. PubMed |
| Ibrutinib Blocks YAP1 Activation and Reverses BRAF Inhibitor Resistance in Melanoma Cells. Misek SA, Newbury PA, Chekalin E, Paithankar S, Doseff AI, Chen B, Gallo KA, Neubig RR. Mol Pharmacol. 2022 Jan;101(1):1-12. doi: 10.1124/molpharm.121.000331. Epub 2021 Nov 3. PubMed |
| ARV-825 Demonstrates Antitumor Activity in Gastric Cancer via MYC-Targets and G2M-Checkpoint Signaling Pathways. Liao X, Qian X, Zhang Z, Tao Y, Li Z, Zhang Q, Liang H, Li X, Xie Y, Zhuo R, Chen Y, Jiang Y, Cao H, Niu J, Xue C, Ni J, Pan J, Cui D. Front Oncol. 2021 Oct 18;11:753119. doi: 10.3389/fonc.2021.753119. eCollection 2021. PubMed |
| CRISPR-based RNA-binding protein mapping in live cells. Chen B, Shi H, Zhang J, Zhou C, Han M, Jiang W, Lai Y, Tu X, Li H. Biochem Biophys Res Commun. 2021 Oct 29;583:79-85. doi: 10.1016/j.bbrc.2021.10.059. PubMed |
| CEBPG promotes acute myeloid leukemia progression by enhancing EIF4EBP1. Jiang Y, Wu SY, Chen YL, Zhang ZM, Tao YF, Xie Y, Liao XM, Li XL, Li G, Wu D, Wang HR, Zuo R, Cao HB, Pan JJ, Yu JJ, Jia SQ, Zhang Z, Chu XR, Zhang YP, Feng CX, Wang JW, Hu SY, Li ZH, Pan J, Fang F, Lu J. Cancer Cell Int. 2021 Nov 7;21(1):598. doi: 10.1186/s12935-021-02305-z. PubMed |
| Optimized protocol to create deletion in adherent cell lines using CRISPR/Cas9 system. Farooq U, Notani D. STAR Protoc. 2021 Oct 22;2(4):100857. doi: 10.1016/j.xpro.2021.100857. eCollection 2021 Dec 17. PubMed |
| A genetic screen in macrophages identifies new regulators of IFNgamma-inducible MHCII that contribute to T cell activation. Kiritsy MC, Ankley LM, Trombley J, Huizinga GP, Lord AE, Orning P, Elling R, Fitzgerald KA, Olive AJ. Elife. 2021 Nov 8;10. pii: 65110. doi: 10.7554/eLife.65110. PubMed |
| Mutation Y453F in the spike protein of SARS-CoV-2 enhances interaction with the mink ACE2 receptor for host adaption. Ren W, Lan J, Ju X, Gong M, Long Q, Zhu Z, Yu Y, Wu J, Zhong J, Zhang R, Fan S, Zhong G, Huang A, Wang X, Ding Q. PLoS Pathog. 2021 Nov 8;17(11):e1010053. doi: 10.1371/journal.ppat.1010053. eCollection 2021 Nov. PubMed |
| DeltaNp63alpha promotes Epstein-Barr virus latency in undifferentiated epithelial cells. Van Sciver N, Ohashi M, Nawandar DM, Pauly NP, Lee D, Makielski KR, Bristol JA, Tsao SW, Lambert PF, Johannsen EC, Kenney SC. PLoS Pathog. 2021 Nov 8;17(11):e1010045. doi: 10.1371/journal.ppat.1010045. eCollection 2021 Nov. PubMed |
| Molecular basis of ubiquitin-specific protease 8 autoinhibition by the WW-like domain. Kakihara K, Asamizu K, Moritsugu K, Kubo M, Kitaguchi T, Endo A, Kidera A, Ikeguchi M, Kato A, Komada M, Fukushima T. Commun Biol. 2021 Nov 8;4(1):1272. doi: 10.1038/s42003-021-02802-x. PubMed |
| The chemotherapeutic CX-5461 primarily targets TOP2B and exhibits selective activity in high-risk neuroblastoma. Pan M, Wright WC, Chapple RH, Zubair A, Sandhu M, Batchelder JE, Huddle BC, Low J, Blankenship KB, Wang Y, Gordon B, Archer P, Brady SW, Natarajan S, Posgai MJ, Schuetz J, Miller D, Kalathur R, Chen S, Connelly JP, Babu MM, Dyer MA, Pruett-Miller SM, Freeman BB 3rd, Chen T, Godley LA, Blanchard SC, Stewart E, Easton J, Geeleher P. Nat Commun. 2021 Nov 9;12(1):6468. doi: 10.1038/s41467-021-26640-x. PubMed |
| The cell-surface 5'-nucleotidase CD73 defines a functional T memory cell subset that declines with age. Fang F, Cao W, Zhu W, Lam N, Li L, Gaddam S, Wang Y, Kim C, Lambert S, Zhang H, Hu B, Farber DL, Weyand CM, Goronzy JJ. Cell Rep. 2021 Nov 9;37(6):109981. doi: 10.1016/j.celrep.2021.109981. PubMed |
| TIAM1-RAC1 promote small-cell lung cancer cell survival through antagonizing Nur77-induced BCL2 conformational change. Payapilly A, Guilbert R, Descamps T, White G, Magee P, Zhou C, Kerr A, Simpson KL, Blackhall F, Dive C, Malliri A. Cell Rep. 2021 Nov 9;37(6):109979. doi: 10.1016/j.celrep.2021.109979. PubMed |
| CRISPR/Cas9 genome editing reveals an essential role for basigin in maintaining a nonkeratinized squamous epithelium in cornea. Woodward AM, Feeley MN, Rinaldi J, Argueso P. FASEB Bioadv. 2021 Aug 30;3(11):897-908. doi: 10.1096/fba.2021-00067. eCollection 2021 Nov. PubMed |
| The specificity of the malarial VAR2CSA protein for chondroitin sulfate depends on 4-O-sulfation and ligand accessibility. Spliid CB, Toledo AG, Sanderson P, Mao Y, Gatto F, Gustavsson T, Choudhary S, Saldanha AL, Vogelsang RP, Gogenur I, Theander TG, Leach FE 3rd, Amster IJ, Esko JD, Salanti A, Clausen TM. J Biol Chem. 2021 Dec;297(6):101391. doi: 10.1016/j.jbc.2021.101391. Epub 2021 Nov 8. PubMed |
| Cotargeting of Bcl-2 and Mcl-1 shows promising antileukemic activity against AML cells including those with acquired cytarabine resistance. Liu F, Zhao Q, Su Y, Lv J, Gai Y, Liu S, Lin H, Wang Y, Wang G. Exp Hematol. 2022 Jan;105:39-49. doi: 10.1016/j.exphem.2021.10.006. Epub 2021 Nov 9. PubMed |
| Proteotoxic Stress as an Exploitable Vulnerability in Cells with Hyperactive AKT. Babagana M, Brown LR, Slabodkin HZ, Kichina JV, Kandel ES. Int J Mol Sci. 2021 Oct 21;22(21). pii: ijms222111376. doi: 10.3390/ijms222111376. PubMed |
| Integrin alpha5 mediates cancer cell-fibroblast adhesion and peritoneal dissemination of diffuse-type gastric carcinoma. Miyamoto S, Nagano Y, Miyazaki M, Nagamura Y, Sasaki K, Kawamura T, Yanagihara K, Imai T, Ohki R, Yashiro M, Tanaka M, Sakai R, Yamaguchi H. Cancer Lett. 2022 Feb 1;526:335-345. doi: 10.1016/j.canlet.2021.11.008. Epub 2021 Nov 12. PubMed |
| LIN28B alters ribosomal dynamics to promote metastasis in MYCN-driven malignancy. Missios P, da Rocha EL, Pearson DS, Philipp J, Aleman MM, Pirouz M, Farache D, Franses JW, Kubaczka C, Tsanov KM, Jha DK, Pepe-Mooney B, Powers JT, Gregory RI, Lee AS, Dominguez D, Ting DT, Daley GQ. J Clin Invest. 2021 Nov 15;131(22). pii: 145142. doi: 10.1172/JCI145142. PubMed |
| Folliculin impairs breast tumor growth by repressing TFE3-dependent induction of the Warburg effect and angiogenesis. El-Houjeiri L, Biondini M, Paquette M, Kuasne H, Pacis A, Park M, Siegel PM, Pause A. J Clin Invest. 2021 Nov 15;131(22). pii: 144871. doi: 10.1172/JCI144871. PubMed |
| Phenotyping clonal populations of glioma stem cell reveals a high degree of plasticity in response to changes of microenvironment. Innes JA, Lowe AS, Fonseca R, Aley N, El-Hassan T, Constantinou M, Lau J, Eddaoudi A, Marino S, Brandner S. Lab Invest. 2022 Feb;102(2):172-184. doi: 10.1038/s41374-021-00695-2. Epub 2021 Nov 15. PubMed |
| Homeoprotein SIX1 compromises antitumor immunity through TGF-beta-mediated regulation of collagens. Liu W, Gao M, Li L, Chen Y, Fan H, Cai Q, Shi Y, Pan C, Liu J, Cheng LS, Yang H, Cheng G. Cell Mol Immunol. 2021 Dec;18(12):2660-2672. doi: 10.1038/s41423-021-00800-x. Epub 2021 Nov 15. PubMed |
| Mitophagy mediates metabolic reprogramming of induced pluripotent stem cells undergoing endothelial differentiation. Krantz S, Kim YM, Srivastava S, Leasure JW, Toth PT, Marsboom G, Rehman J. J Biol Chem. 2021 Dec;297(6):101410. doi: 10.1016/j.jbc.2021.101410. Epub 2021 Nov 14. PubMed |
| UBR7 acts as a histone chaperone for post-nucleosomal histone H3. Hogan AK, Sathyan KM, Willis AB, Khurana S, Srivastava S, Zasadzinska E, Lee AS, Bailey AO, Gaynes MN, Huang J, Bodner J, Rosencrance CD, Wong KA, Morgan MA, Eagen KP, Shilatifard A, Foltz DR. EMBO J. 2021 Dec 15;40(24):e108307. doi: 10.15252/embj.2021108307. Epub 2021 Nov 17. PubMed |
| Evaluating Humoral Immunity against SARS-CoV-2: Validation of a Plaque-Reduction Neutralization Test and a Multilaboratory Comparison of Conventional and Surrogate Neutralization Assays. Valcourt EJ, Manguiat K, Robinson A, Lin YC, Abe KT, Mubareka S, Shigayeva A, Zhong Z, Girardin RC, DuPuis A, Payne A, McDonough K, Wang Z, Gasser R, Laumaea A, Benlarbi M, Richard J, Prevost J, Anand SP, Dimitrova K, Phillipson C, McGeer A, Gingras AC, Liang C, Petric M, Sekirov I, Morshed M, Finzi A, Drebot M, Wood H. Microbiol Spectr. 2021 Dec 22;9(3):e0088621. doi: 10.1128/Spectrum.00886-21. Epub 2021 Nov 17. PubMed |
| Targeting the spliceosome through RBM39 degradation results in exceptional responses in high-risk neuroblastoma models. Singh S, Quarni W, Goralski M, Wan S, Jin H, Van de Velde LA, Fang J, Wu Q, Abu-Zaid A, Wang T, Singh R, Craft D, Fan Y, Confer T, Johnson M, Akers WJ, Wang R, Murray PJ, Thomas PG, Nijhawan D, Davidoff AM, Yang J. Sci Adv. 2021 Nov 19;7(47):eabj5405. doi: 10.1126/sciadv.abj5405. Epub 2021 Nov 17. PubMed |
| MAD2L1 Functions As a Novel Diagnostic and Predictive Biomarker in Cholangiocarcinoma. Gao Y, Liu Y, Sun L, Ouyang X, Zhu C, Qin X. Genet Test Mol Biomarkers. 2021 Nov;25(11):685-695. doi: 10.1089/gtmb.2021.0122. PubMed |
| Locus-Conserved Circular RNA cZNF292 Controls Endothelial Cell Flow Responses. Heumuller AW, Jones AN, Mourao A, Klangwart M, Shi C, Wittig I, Fischer A, Muhly-Reinholz M, Buchmann GK, Dieterich C, Potente M, Braun T, Grote P, Jae N, Sattler M, Dimmeler S. Circ Res. 2022 Jan 7;130(1):67-79. doi: 10.1161/CIRCRESAHA.121.320029. Epub 2021 Nov 18. PubMed |
| HSP27 protects against ferroptosis of glioblastoma cells. Yuan F, Sun Q, Zhang S, Ye L, Xu Y, Xu Z, Liu B, Zhang S, Chen Q. Hum Cell. 2022 Jan;35(1):238-249. doi: 10.1007/s13577-021-00645-6. Epub 2021 Nov 17. PubMed |
Identification of proximal SUMO-dependent interactors using SUMO-ID.
Barroso-Gomila O, Trulsson F, Muratore V, Canosa I, Merino-Cacho L, Cortazar AR, Perez C, Azkargorta M, Iloro I, Carracedo A, Aransay AM, Elortza F, Mayor U, Vertegaal ACO, Barrio R, Sutherland JD.
Nat Commun. 2021 Nov 18;12(1):6671. doi: 10.1038/s41467-021-26807-6.
PubMed
Associated Plasmids |
| Defactinib inhibits PYK2 phosphorylation of IRF5 and reduces intestinal inflammation. Ryzhakov G, Almuttaqi H, Corbin AL, Berthold DL, Khoyratty T, Eames HL, Bullers S, Pearson C, Ai Z, Zec K, Bonham S, Fischer R, Jostins-Dean L, Travis SPL, Kessler BM, Udalova IA. Nat Commun. 2021 Nov 18;12(1):6702. doi: 10.1038/s41467-021-27038-5. PubMed |
| CRISPR screens unveil signal hubs for nutrient licensing of T cell immunity. Long L, Wei J, Lim SA, Raynor JL, Shi H, Connelly JP, Wang H, Guy C, Xie B, Chapman NM, Fu G, Wang Y, Huang H, Su W, Saravia J, Risch I, Wang YD, Li Y, Niu M, Dhungana Y, Kc A, Zhou P, Vogel P, Yu J, Pruett-Miller SM, Peng J, Chi H. Nature. 2021 Dec;600(7888):308-313. doi: 10.1038/s41586-021-04109-7. Epub 2021 Nov 18. PubMed |
| AMBRA1 regulates mitophagy by interacting with ATAD3A and promoting PINK1 stability. Di Rienzo M, Romagnoli A, Ciccosanti F, Refolo G, Consalvi V, Arena G, Valente EM, Piacentini M, Fimia GM. Autophagy. 2021 Nov 19:1-11. doi: 10.1080/15548627.2021.1997052. PubMed |
| Large scale discovery of coronavirus-host factor protein interaction motifs reveals SARS-CoV-2 specific mechanisms and vulnerabilities. Kruse T, Benz C, Garvanska DH, Lindqvist R, Mihalic F, Coscia F, Inturi R, Sayadi A, Simonetti L, Nilsson E, Ali M, Kliche J, Moliner Morro A, Mund A, Andersson E, McInerney G, Mann M, Jemth P, Davey NE, Overby AK, Nilsson J, Ivarsson Y. Nat Commun. 2021 Nov 19;12(1):6761. doi: 10.1038/s41467-021-26498-z. PubMed |
| Runx3 is required for oncogenic Myc upregulation in p53-deficient osteosarcoma. Otani S, Date Y, Ueno T, Ito T, Kajikawa S, Omori K, Taniuchi I, Umeda M, Komori T, Toguchida J, Ito K. Oncogene. 2022 Jan;41(5):683-691. doi: 10.1038/s41388-021-02120-w. Epub 2021 Nov 22. PubMed |
| BSG/CD147 and ACE2 receptors facilitate SARS-CoV-2 infection of human iPS cell-derived kidney podocytes. Kalejaiye TD, Bhattacharya R, Burt MA, Travieso T, Okafor AE, Mou X, Blasi M, Musah S. bioRxiv. 2021 Nov 17. doi: 10.1101/2021.11.16.468893. PubMed |
| SEC23A rescues SEC23B-deficient congenital dyserythropoietic anemia type II. King R, Lin Z, Balbin-Cuesta G, Myers G, Friedman A, Zhu G, McGee B, Saunders TL, Kurita R, Nakamura Y, Engel JD, Reddy P, Khoriaty R. Sci Adv. 2021 Nov 26;7(48):eabj5293. doi: 10.1126/sciadv.abj5293. Epub 2021 Nov 24. PubMed |
| Immuno-transcriptomic profiling of extracranial pediatric solid malignancies. Brohl AS, Sindiri S, Wei JS, Milewski D, Chou HC, Song YK, Wen X, Kumar J, Reardon HV, Mudunuri US, Collins JR, Nagaraj S, Gangalapudi V, Tyagi M, Zhu YJ, Masih KE, Yohe ME, Shern JF, Qi Y, Guha U, Catchpoole D, Orentas RJ, Kuznetsov IB, Llosa NJ, Ligon JA, Turpin BK, Leino DG, Iwata S, Andrulis IL, Wunder JS, Toledo SRC, Meltzer PS, Lau C, Teicher BA, Magnan H, Ladanyi M, Khan J. Cell Rep. 2021 Nov 23;37(8):110047. doi: 10.1016/j.celrep.2021.110047. PubMed |
| A trivalent nucleosome interaction by PHIP/BRWD2 is disrupted in neurodevelopmental disorders and cancer. Morgan MAJ, Popova IK, Vaidya A, Burg JM, Marunde MR, Rendleman EJ, Dumar ZJ, Watson R, Meiners MJ, Howard SA, Khalatyan N, Vaughan RM, Rothbart SB, Keogh MC, Shilatifard A. Genes Dev. 2021 Dec 1;35(23-24):1642-1656. doi: 10.1101/gad.348766.121. Epub 2021 Nov 24. PubMed |
| FAM72A antagonizes UNG2 to promote mutagenic repair during antibody maturation. Feng Y, Li C, Stewart JA, Barbulescu P, Seija Desivo N, Alvarez-Quilon A, Pezo RC, Perera MLW, Chan K, Tong AHY, Mohamad-Ramshan R, Berru M, Nakib D, Li G, Kardar GA, Carlyle JR, Moffat J, Durocher D, Di Noia JM, Bhagwat AS, Martin A. Nature. 2021 Dec;600(7888):324-328. doi: 10.1038/s41586-021-04144-4. Epub 2021 Nov 24. PubMed |
| Facile Fabrication of Three-Dimensional Hydrogel Film with Complex Tissue Morphology. An YH, Kim SH. Bioengineering (Basel). 2021 Oct 27;8(11). pii: bioengineering8110164. doi: 10.3390/bioengineering8110164. PubMed |
| Nanovesicles derived from bispecific CAR-T cells targeting the spike protein of SARS-CoV-2 for treating COVID-19. Zhu T, Xiao Y, Meng X, Tang L, Li B, Zhao Z, Tan Q, Shan H, Liu L, Huang X. J Nanobiotechnology. 2021 Nov 25;19(1):391. doi: 10.1186/s12951-021-01148-0. PubMed |
| Development of a BCL-xL and BCL-2 dual degrader with improved anti-leukemic activity. Lv D, Pal P, Liu X, Jia Y, Thummuri D, Zhang P, Hu W, Pei J, Zhang Q, Zhou S, Khan S, Zhang X, Hua N, Yang Q, Arango S, Zhang W, Nayak D, Olsen SK, Weintraub ST, Hromas R, Konopleva M, Yuan Y, Zheng G, Zhou D. Nat Commun. 2021 Nov 25;12(1):6896. doi: 10.1038/s41467-021-27210-x. PubMed |
| A cell-based multiplex immunoassay platform using fluorescent protein-barcoded reporter cell lines. Song S, Manook M, Kwun J, Jackson AM, Knechtle SJ, Kelsoe G. Commun Biol. 2021 Nov 25;4(1):1338. doi: 10.1038/s42003-021-02881-w. PubMed |
| Preclinical testing of chimeric antigen receptor T cells in neuroblastoma mouse models. Li N, Nguyen R, Thiele CJ, Ho M. STAR Protoc. 2021 Nov 10;2(4):100942. doi: 10.1016/j.xpro.2021.100942. eCollection 2021 Dec 17. PubMed |
| MAPK Inhibition Requires Active RAC1 Signaling to Effectively Improve Iodide Uptake by Thyroid Follicular Cells. Faria M, Domingues R, Bugalho MJ, Matos P, Silva AL. Cancers (Basel). 2021 Nov 22;13(22). pii: cancers13225861. doi: 10.3390/cancers13225861. PubMed |
| Comprehensive Analysis of microRNAs in Human Adult Erythropoiesis. Nath A, Rayabaram J, Ijee S, Bagchi A, Chaudhury AD, Roy D, Chambayil K, Singh J, Nakamura Y, Velayudhan SR. Cells. 2021 Nov 4;10(11). pii: cells10113018. doi: 10.3390/cells10113018. PubMed |
| Identification of Cellular Factors Required for SARS-CoV-2 Replication. Synowiec A, Jedrysik M, Branicki W, Klajmon A, Lei J, Owczarek K, Suo C, Szczepanski A, Wang J, Zhang P, Labaj PP, Pyrc K. Cells. 2021 Nov 13;10(11). pii: cells10113159. doi: 10.3390/cells10113159. PubMed |
| BAF complexes drive proliferation and block myogenic differentiation in fusion-positive rhabdomyosarcoma. Laubscher D, Gryder BE, Sunkel BD, Andresson T, Wachtel M, Das S, Roschitzki B, Wolski W, Wu XS, Chou HC, Song YK, Wang C, Wei JS, Wang M, Wen X, Ngo QA, Marques JG, Vakoc CR, Schafer BW, Stanton BZ, Khan J. Nat Commun. 2021 Nov 26;12(1):6924. doi: 10.1038/s41467-021-27176-w. PubMed |
Deciphering cell signaling networks with massively multiplexed biosensor barcoding.
Yang JM, Chi WY, Liang J, Takayanagi S, Iglesias PA, Huang CH.
Cell. 2021 Dec 9;184(25):6193-6206.e14. doi: 10.1016/j.cell.2021.11.005. Epub 2021 Nov 26.
PubMed
Associated Plasmids |
| ONECUT2 facilitates hepatocellular carcinoma metastasis by transcriptionally upregulating FGF2 and ACLY. Liu D, Zhang T, Chen X, Zhang B, Wang Y, Xie M, Ji X, Sun M, Huang W, Xia L. Cell Death Dis. 2021 Nov 27;12(12):1113. doi: 10.1038/s41419-021-04410-3. PubMed |
| GRAMD4 inhibits tumour metastasis by recruiting the E3 ligase ITCH to target TAK1 for degradation in hepatocellular carcinoma. Ge QY, Chen J, Li GX, Tan XL, Song J, Ning D, Mo J, Du PC, Liu QM, Liang HF, Ding ZY, Zhang XW, Zhang BX. Clin Transl Med. 2021 Nov;11(11):e635. doi: 10.1002/ctm2.635. PubMed |
| The SETDB1-TRIM28 Complex Suppresses Antitumor Immunity. Lin J, Guo D, Liu H, Zhou W, Wang C, Muller I, Kossenkov AV, Drapkin R, Bitler BG, Helin K, Zhang R. Cancer Immunol Res. 2021 Dec;9(12):1413-1424. doi: 10.1158/2326-6066.CIR-21-0754. PubMed |
| Tumor evolution selectively inactivates the core microRNA machinery for immune evasion. Song TY, Long M, Zhao HX, Zou MW, Fan HJ, Liu Y, Geng CL, Song MF, Liu YF, Chen JY, Yang YL, Zhou WR, Huang DW, Peng B, Peng ZG, Cang Y. Nat Commun. 2021 Dec 1;12(1):7003. doi: 10.1038/s41467-021-27331-3. PubMed |
| Cross-species analysis of viral nucleic acid interacting proteins identifies TAOKs as innate immune regulators. Pennemann FL, Mussabekova A, Urban C, Stukalov A, Andersen LL, Grass V, Lavacca TM, Holze C, Oubraham L, Benamrouche Y, Girardi E, Boulos RE, Hartmann R, Superti-Furga G, Habjan M, Imler JL, Meignin C, Pichlmair A. Nat Commun. 2021 Dec 1;12(1):7009. doi: 10.1038/s41467-021-27192-w. PubMed |
| A novel RNA-mediated mechanism causing down-regulation of insulating promoter interactions in human embryonic stem cells. Liu Y, Williams SG, Jones HR, Keavney BD, Choy MK. Sci Rep. 2021 Dec 1;11(1):23233. doi: 10.1038/s41598-021-02373-1. PubMed |
| Genetically edited hepatic cells expressing the NTCP-S267F variant are resistant to hepatitis B virus infection. Uchida T, Park SB, Inuzuka T, Zhang M, Allen JN, Chayama K, Liang TJ. Mol Ther Methods Clin Dev. 2021 Nov 10;23:597-605. doi: 10.1016/j.omtm.2021.11.002. eCollection 2021 Dec 10. PubMed |
| A distributed residue network permits conformational binding specificity in a conserved family of actin remodelers. Hwang T, Parker SS, Hill SM, Ilunga MW, Grant RA, Mouneimne G, Keating AE. Elife. 2021 Dec 2;10:e70601. doi: 10.7554/eLife.70601. PubMed |
| Personalized phosphoproteomics identifies functional signaling. Needham EJ, Hingst JR, Parker BL, Morrison KR, Yang G, Onslev J, Kristensen JM, Hojlund K, Ling NXY, Oakhill JS, Richter EA, Kiens B, Petersen J, Pehmoller C, James DE, Wojtaszewski JFP, Humphrey SJ. Nat Biotechnol. 2022 Apr;40(4):576-584. doi: 10.1038/s41587-021-01099-9. Epub 2021 Dec 2. PubMed |
| Apoptolidin family glycomacrolides target leukemia through inhibition of ATP synthase. Reisman BJ, Guo H, Ramsey HE, Wright MT, Reinfeld BI, Ferrell PB, Sulikowski GA, Rathmell WK, Savona MR, Plate L, Rubinstein JL, Bachmann BO. Nat Chem Biol. 2022 Apr;18(4):360-367. doi: 10.1038/s41589-021-00900-9. Epub 2021 Dec 2. PubMed |
| Large Multicohort Study Reveals a Prostate Cancer Susceptibility Allele at 5p15 Regulating TERT via Androgen Signaling-Orchestrated Chromatin Binding of E2F1 and MYC. Dong X, Zhang Q, Hao J, Xie Q, Xu B, Zhang P, Lu H, Huang Q, Yang T, Wei GH, Na R, Gao P. Front Oncol. 2021 Nov 10;11:754206. doi: 10.3389/fonc.2021.754206. eCollection 2021. PubMed |
| APEX-mediated Proximity Labeling of Proteins in Cells Targeted by Extracellular Vesicles. Song L, Chen J, Sun A, Schekman R. Bio Protoc. 2021 Nov 5;11(21):e4213. doi: 10.21769/BioProtoc.4213. eCollection 2021 Nov 5. PubMed |
| A Nucleocapsid-based Transcomplementation Cell Culture System of SARS-CoV-2 to Recapitulate the Complete Viral Life Cycle. Yu Y, Ju X, Ding Q. Bio Protoc. 2021 Nov 5;11(21):e4257. doi: 10.21769/BioProtoc.4257. eCollection 2021 Nov 5. PubMed |
| AMBRA1 promotes dsRNA- and virus-induced apoptosis through interacting with and stabilizing MAVS. Lin Y, Huang C, Gao H, Li X, Lin Q, Zhou S, Huo Z, Huang Y, Liu C, Zhang P. J Cell Sci. 2022 Jan 1;135(1). pii: 273618. doi: 10.1242/jcs.258910. Epub 2022 Jan 7. PubMed |
| Elimination of fluorescent protein immunogenicity permits modeling of metastasis in immune-competent settings. Grzelak CA, Goddard ET, Lederer EE, Rajaram K, Dai J, Shor RE, Lim AR, Kim J, Beronja S, Funnell APW, Ghajar CM. Cancer Cell. 2022 Jan 10;40(1):1-2. doi: 10.1016/j.ccell.2021.11.004. Epub 2021 Dec 2. PubMed |
| RIPK1 dephosphorylation and kinase activation by PPP1R3G/PP1gamma promote apoptosis and necroptosis. Du J, Xiang Y, Liu H, Liu S, Kumar A, Xing C, Wang Z. Nat Commun. 2021 Dec 3;12(1):7067. doi: 10.1038/s41467-021-27367-5. PubMed |
| Extracellular cathepsin Z signals through the alpha5 integrin and augments NLRP3 inflammasome activation. Campden RI, Warren AL, Greene CJ, Chiriboga JA, Arnold CR, Aggarwal D, McKenna N, Sandall CF, MacDonald JA, Yates RM. J Biol Chem. 2022 Jan;298(1):101459. doi: 10.1016/j.jbc.2021.101459. Epub 2021 Dec 2. PubMed |
| Transmembrane Protein TMEM230, a Target of Glioblastoma Therapy. Cocola C, Magnaghi V, Abeni E, Pelucchi P, Martino V, Vilardo L, Piscitelli E, Consiglio A, Grillo G, Mosca E, Gualtierotti R, Mazzaccaro D, La Sala G, Di Pietro C, Palizban M, Liuni S, DePedro G, Morara S, Nano G, Kehler J, Greve B, Noghero A, Marazziti D, Bussolino F, Bellipanni G, D'Agnano I, Gotte M, Zucchi I, Reinbold R. Front Cell Neurosci. 2021 Nov 17;15:703431. doi: 10.3389/fncel.2021.703431. eCollection 2021. PubMed |
| MG1141A as a Highly Potent Monoclonal Neutralizing Antibody Against SARS-CoV-2 Variants. Lee S, Jang S, Kang J, Park SB, Han YW, Nam H, Kim M, Lee J, Cho KJ, Kim J, Oh M, Ryu J, Seok JH, Kim Y, Lee JB, Park MS, Kim YS, Park H, Kim DS. Front Immunol. 2021 Nov 18;12:778829. doi: 10.3389/fimmu.2021.778829. eCollection 2021. PubMed |
| Single-cell characterization of CRISPR-modified transcript isoforms with nanopore sequencing. Kim HS, Grimes SM, Hooker AC, Lau BT, Ji HP. Genome Biol. 2021 Dec 6;22(1):331. doi: 10.1186/s13059-021-02554-1. PubMed |
| Identification of Drug Transporter Genomic Variants and Inhibitors That Protect Against Doxorubicin-Induced Cardiotoxicity. Magdy T, Jouni M, Kuo HH, Weddle CJ, Lyra-Leite D, Fonoudi H, Romero-Tejeda M, Gharib M, Javed H, Fajardo G, Ross CJD, Carleton BC, Bernstein D, Burridge PW. Circulation. 2022 Jan 25;145(4):279-294. doi: 10.1161/CIRCULATIONAHA.121.055801. Epub 2021 Dec 7. PubMed |
| TIFAB accelerates MLL-AF9-Induced acute myeloid leukemia through upregulation of HOXA9. Zhao J, Xiu Y, Fu L, Dong Q, Borcherding N, Wang Y, Li Q, De Silva NS, Klein U, Boyce BF, Zhao C. iScience. 2021 Nov 12;24(12):103425. doi: 10.1016/j.isci.2021.103425. eCollection 2021 Dec 17. PubMed |
| Integrated stress response regulates GDF15 secretion from adipocytes, preferentially suppresses appetite for a high-fat diet and improves obesity. Miyake M, Zhang J, Yasue A, Hisanaga S, Tsugawa K, Sakaue H, Oyadomari M, Kiyonari H, Oyadomari S. iScience. 2021 Nov 15;24(12):103448. doi: 10.1016/j.isci.2021.103448. eCollection 2021 Dec 17. PubMed |
| Inhibition of the PLK1-Coupled Cell Cycle Machinery Overcomes Resistance to Oxaliplatin in Colorectal Cancer. Yu Z, Deng P, Chen Y, Liu S, Chen J, Yang Z, Chen J, Fan X, Wang P, Cai Z, Wang Y, Hu P, Lin D, Xiao R, Zou Y, Huang Y, Yu Q, Lan P, Tan J, Wu X. Adv Sci (Weinh). 2021 Dec;8(23):e2100759. doi: 10.1002/advs.202100759. Epub 2021 Oct 28. PubMed |
| RNA modifications detection by comparative Nanopore direct RNA sequencing. Leger A, Amaral PP, Pandolfini L, Capitanchik C, Capraro F, Miano V, Migliori V, Toolan-Kerr P, Sideri T, Enright AJ, Tzelepis K, van Werven FJ, Luscombe NM, Barbieri I, Ule J, Fitzgerald T, Birney E, Leonardi T, Kouzarides T. Nat Commun. 2021 Dec 10;12(1):7198. doi: 10.1038/s41467-021-27393-3. PubMed |
| Bone marrow derived-mesenchymal stem cell improves diabetes-associated fatty liver via mitochondria transformation in mice. Bi Y, Guo X, Zhang M, Zhu K, Shi C, Fan B, Wu Y, Yang Z, Ji G. Stem Cell Res Ther. 2021 Dec 11;12(1):602. doi: 10.1186/s13287-021-02663-5. PubMed |
| BoxCar and shotgun proteomic analyses reveal molecular networks regulated by UBR5 in prostate cancer. Yan Y, Zhou B, Lee YJ, You S, Freeman MR, Yang W. Proteomics. 2022 Feb;22(4):e2100172. doi: 10.1002/pmic.202100172. Epub 2021 Dec 23. PubMed |
Rapid genome editing by CRISPR-Cas9-POLD3 fusion.
Reint G, Li Z, Labun K, Keskitalo S, Soppa I, Mamia K, Tolo E, Szymanska M, Meza-Zepeda LA, Lorenz S, Cieslar-Pobuda A, Hu X, Bordin DL, Staerk J, Valen E, Schmierer B, Varjosalo M, Taipale J, Haapaniemi E.
Elife. 2021 Dec 13;10. pii: 75415. doi: 10.7554/eLife.75415.
PubMed
Associated Plasmids |
| The OM-85 bacterial lysate inhibits SARS-CoV-2 infection of epithelial cells by downregulating SARS-CoV-2 receptor expression. Pivniouk V, Pivniouk O, DeVries A, Uhrlaub JL, Michael A, Pivniouk D, VanLinden SR, Conway MY, Hahn S, Malone SP, Ezeh P, Churko JM, Anderson D, Kraft M, Nikolich-Zugich J, Vercelli D. J Allergy Clin Immunol. 2022 Mar;149(3):923-933.e6. doi: 10.1016/j.jaci.2021.11.019. Epub 2021 Dec 10. PubMed |
| Nuclear pore protein NUP210 depletion suppresses metastasis through heterochromatin-mediated disruption of tumor cell mechanical response. Amin R, Shukla A, Zhu JJ, Kim S, Wang P, Tian SZ, Tran AD, Paul D, Cappell SD, Burkett S, Liu H, Lee MP, Kruhlak MJ, Dwyer JE, Simpson RM, Hager GL, Ruan Y, Hunter KW. Nat Commun. 2021 Dec 13;12(1):7216. doi: 10.1038/s41467-021-27451-w. PubMed |
| Peroxisomal beta-oxidation acts as a sensor for intracellular fatty acids and regulates lipolysis. Ding L, Sun W, Balaz M, He A, Klug M, Wieland S, Caiazzo R, Raverdy V, Pattou F, Lefebvre P, Lodhi IJ, Staels B, Heim M, Wolfrum C. Nat Metab. 2021 Dec;3(12):1648-1661. doi: 10.1038/s42255-021-00489-2. Epub 2021 Dec 13. PubMed |
| A minimal standardized human bone marrow microphysiological system to assess resident cell behavior during normal and pathological processes. Voeltzel T, Fossard G, Degaud M, Geistlich K, Gadot N, Jeanpierre S, Mikaelian I, Brevet M, Anginot A, Le Bousse-Kerdiles MC, Trichet V, Lefort S, Maguer-Satta V. Biomater Sci. 2022 Jan 18;10(2):485-498. doi: 10.1039/d1bm01098k. PubMed |
| Ablation of T cell-associated PD-1H enhances functionality and promotes adoptive immunotherapy. Hu L, Chen L, Xiao Z, Zheng X, Chen Y, Xian N, Cho C, Luo L, Huang G, Chen L. JCI Insight. 2022 Jan 25;7(2). pii: 148247. doi: 10.1172/jci.insight.148247. PubMed |
| Senolytic-Mediated Elimination of Head and Neck Tumor Cells Induced Into Senescence by Cisplatin. Ahmadinejad F, Bos T, Hu B, Britt E, Koblinski J, Souers AJ, Leverson JD, Faber AC, Gewirtz DA, Harada H. Mol Pharmacol. 2022 Mar;101(3):168-180. doi: 10.1124/molpharm.121.000354. Epub 2021 Dec 14. PubMed |
| Infection of wild-type mice by SARS-CoV-2 B.1.351 variant indicates a possible novel cross-species transmission route. Pan T, Chen R, He X, Yuan Y, Deng X, Li R, Yan H, Yan S, Liu J, Zhang Y, Zhang X, Yu F, Zhou M, Ke C, Ma X, Zhang H. Signal Transduct Target Ther. 2021 Dec 14;6(1):420. doi: 10.1038/s41392-021-00848-1. PubMed |
| Biallelic mutations in calcium release activated channel regulator 2A (CRACR2A) cause a primary immunodeficiency disorder. Wu B, Rice L, Shrimpton J, Lawless D, Walker K, Carter C, McKeown L, Anwar R, Doody GM, Srikanth S, Gwack Y, Savic S. Elife. 2021 Dec 15;10. pii: 72559. doi: 10.7554/eLife.72559. PubMed |
| SARS-CoV-2 spike protein harnesses SNX27-mediated endocytic recycling pathway. Zhao L, Zhong K, Zhao J, Yong X, Tong A, Jia D. MedComm (2020). 2021 Oct 8. pii: MCO292. doi: 10.1002/mco2.92. PubMed |
| Defective brown adipose tissue thermogenesis and impaired glucose metabolism in mice lacking Letmd1. Choi KM, Kim JH, Kong X, Isik M, Zhang J, Lim HW, Yoon JC. Cell Rep. 2021 Dec 14;37(11):110104. doi: 10.1016/j.celrep.2021.110104. PubMed |
| Downregulation of METTL6 mitigates cell progression, migration, invasion and adhesion in hepatocellular carcinoma by inhibiting cell adhesion molecules. Bolatkan A, Asada K, Kaneko S, Suvarna K, Ikawa N, Machino H, Komatsu M, Shiina S, Hamamoto R. Int J Oncol. 2022 Jan;60(1). pii: 4. doi: 10.3892/ijo.2021.5294. Epub 2021 Dec 16. PubMed |
| Induction of Rosette-to-Lumen stage embryoids using reprogramming paradigms in ESCs. Langkabel J, Horne A, Bonaguro L, Holsten L, Hesse T, Knaus A, Riedel Y, Becker M, Handler K, Elmzzahi T, Bassler K, Reusch N, Yeghiazarian LH, Pecht T, Saglam A, Ulas T, Aschenbrenner AC, Kaiser F, Kubaczka C, Schultze JL, Schorle H. Nat Commun. 2021 Dec 16;12(1):7322. doi: 10.1038/s41467-021-27586-w. PubMed |
| Notch1 promotes ordered revascularization through Semaphorin 3g modulation of downstream vascular patterning signalling factors. Hyun J, Lee M, Rehman J, Pajcini KV, Malik AB. J Physiol. 2022 Feb;600(3):509-530. doi: 10.1113/JP282286. Epub 2022 Jan 17. PubMed |
| VLDLR and ApoER2 are receptors for multiple alphaviruses. Clark LE, Clark SA, Lin C, Liu J, Coscia A, Nabel KG, Yang P, Neel DV, Lee H, Brusic V, Stryapunina I, Plante KS, Ahmed AA, Catteruccia F, Young-Pearse TL, Chiu IM, Llopis PM, Weaver SC, Abraham J. Nature. 2022 Feb;602(7897):475-480. doi: 10.1038/s41586-021-04326-0. Epub 2021 Dec 20. PubMed |
| RB expression confers sensitivity to CDK4/6 inhibitor-mediated radiosensitization across breast cancer subtypes. Pesch AM, Hirsh NH, Michmerhuizen AR, Jungles KM, Wilder-Romans K, Chandler BC, Liu M, Lerner LM, Nino CA, Ward C, Cobain EF, Lawrence TS, Pierce LJ, Rae JM, Speers CW. JCI Insight. 2022 Feb 8;7(3). pii: 154402. doi: 10.1172/jci.insight.154402. PubMed |
| A mechanistic basis for the malignant progression of salivary gland tumors. Taniguchi S, Tanaka Y, Elhance A, Oshimori N. iScience. 2021 Nov 25;24(12):103508. doi: 10.1016/j.isci.2021.103508. eCollection 2021 Dec 17. PubMed |
| Kaposi's sarcoma-associated herpesvirus vFLIP promotes MEndT to generate hybrid M/E state for tumorigenesis. Chen W, Ding Y, Liu D, Lu Z, Wang Y, Yuan Y. PLoS Pathog. 2021 Dec 22;17(12):e1009600. doi: 10.1371/journal.ppat.1009600. eCollection 2021 Dec. PubMed |
| Multifunctional barcoding with ClonMapper enables high-resolution study of clonal dynamics during tumor evolution and treatment. Gutierrez C, Al'Khafaji AM, Brenner E, Johnson KE, Gohil SH, Lin Z, Knisbacher BA, Durrett RE, Li S, Parvin S, Biran A, Zhang W, Rassenti L, Kipps TJ, Livak KJ, Neuberg D, Letai A, Getz G, Wu CJ, Brock A. Nat Cancer. 2021 Jul;2(7):758-772. doi: 10.1038/s43018-021-00222-8. Epub 2021 Jul 12. PubMed |
| Squalene synthase predicts poor prognosis in stage I-III colon adenocarcinoma and synergizes squalene epoxidase to promote tumor progression. Jiang H, Tang E, Chen Y, Liu H, Zhao Y, Lin M, He L. Cancer Sci. 2022 Mar;113(3):971-985. doi: 10.1111/cas.15248. Epub 2022 Jan 6. PubMed |
| Anti-SARS-CoV-2 Activity of Rhamnan Sulfate from Monostroma nitidum. Song Y, He P, Rodrigues AL, Datta P, Tandon R, Bates JT, Bierdeman MA, Chen C, Dordick J, Zhang F, Linhardt RJ. Mar Drugs. 2021 Nov 30;19(12). pii: md19120685. doi: 10.3390/md19120685. PubMed |
| Perturbation of Cellular Redox Homeostasis Dictates Divergent Effects of Polybutyl Cyanoacrylate (PBCA) Nanoparticles on Autophagy. Sonstevold T, Engedal N, Torgersen ML. Cells. 2021 Dec 6;10(12). pii: cells10123432. doi: 10.3390/cells10123432. PubMed |
| RNA uridyl transferases TUT4/7 differentially regulate miRNA variants depending on the cancer cell type. Medhi R, Price J, Furlan G, Gorges B, Sapetschnig A, Miska EA. RNA. 2022 Mar;28(3):353-370. doi: 10.1261/rna.078976.121. Epub 2021 Dec 23. PubMed |
| A protocol for imaging microvilli biogenesis on the surface of cultured porcine kidney epithelial cell monolayers. Gaeta IM, Meenderink LM, Tyska MJ. STAR Protoc. 2021 Dec 10;2(4):100998. doi: 10.1016/j.xpro.2021.100998. eCollection 2021 Dec 17. PubMed |
| MNX1-HNF1B Axis Is Indispensable for Intraductal Papillary Mucinous Neoplasm Lineages. Kato H, Tateishi K, Fujiwara H, Nakatsuka T, Yamamoto K, Kudo Y, Hayakawa Y, Nakagawa H, Tanaka Y, Ijichi H, Otsuka M, Iwadate D, Oyama H, Kanai S, Noguchi K, Suzuki T, Sato T, Hakuta R, Ishigaki K, Saito K, Saito T, Takahara N, Kishikawa T, Hamada T, Takahashi R, Miyabayashi K, Mizuno S, Kogure H, Nakai Y, Hirata Y, Toyoda A, Ichikawa K, Qu W, Morishita S, Arita J, Tanaka M, Ushiku T, Hasegawa K, Fujishiro M, Koike K. Gastroenterology. 2022 Apr;162(4):1272-1287.e16. doi: 10.1053/j.gastro.2021.12.254. Epub 2021 Dec 22. PubMed |
| Human Properdin Released By Infiltrating Neutrophils Can Modulate Influenza A Virus Infection. Varghese PM, Mukherjee S, Al-Mohanna FA, Saleh SM, Almajhdi FN, Beirag N, Alkahtani SH, Rajkumari R, Nal Rogier B, Sim RB, Idicula-Thomas S, Madan T, Murugaiah V, Kishore U. Front Immunol. 2021 Dec 9;12:747654. doi: 10.3389/fimmu.2021.747654. eCollection 2021. PubMed |
| Sulfonated Amphiphilic Poly(alpha)glutamate Amine-A Potential siRNA Nanocarrier for the Treatment of Both Chemo-Sensitive and Chemo-Resistant Glioblastoma Tumors. Krivitsky A, Pozzi S, Yeini E, Israeli Dangoor S, Zur T, Golan S, Krivitsky V, Albeck N, Pisarevsky E, Ofek P, Madi A, Satchi-Fainaro R. Pharmaceutics. 2021 Dec 20;13(12). pii: pharmaceutics13122199. doi: 10.3390/pharmaceutics13122199. PubMed |
| Peroxidasin Enhances Basal Phenotype and Inhibits Branching Morphogenesis in Breast Epithelial Progenitor Cell Line D492. Sigurdardottir AK, Jonasdottir AS, Asbjarnarson A, Helgudottir HR, Gudjonsson T, Traustadottir GA. J Mammary Gland Biol Neoplasia. 2021 Dec;26(4):321-338. doi: 10.1007/s10911-021-09507-1. Epub 2021 Dec 28. PubMed |
| The splicing factor DHX38/PRP16 is required for ovarian clear cell carcinoma tumorigenesis, as revealed by a CRISPR-Cas9 screen. Cona B, Hayashi T, Yamada A, Shimizu N, Yokota N, Nakato R, Shirahige K, Akiyama T. FEBS Open Bio. 2022 Mar;12(3):582-593. doi: 10.1002/2211-5463.13358. Epub 2022 Jan 28. PubMed |
| SIRT2 regulates mitochondrial dynamics and reprogramming via MEK1-ERK-DRP1 and AKT1-DRP1 axes. Cha Y, Kim T, Jeon J, Jang Y, Kim PB, Lopes C, Leblanc P, Cohen BM, Kim KS. Cell Rep. 2021 Dec 28;37(13):110155. doi: 10.1016/j.celrep.2021.110155. PubMed |
| GPNMB overexpression is associated with extensive bone metastasis and poor prognosis in renal cell carcinoma. Zhai JP, Liu ZH, Wang HD, Huang GL, Man LB. Oncol Lett. 2022 Jan;23(1):36. doi: 10.3892/ol.2021.13154. Epub 2021 Dec 1. PubMed |
| A Dual HiBiT-GFP-LC3 Lentiviral Reporter for Autophagy Flux Assessment. Will R, Bauer K, Kudla M, Montero-Vergara J, Wiemann S, Jendrossek V, Pena-Llopis S, Vega-Rubin-de-Celis S. Methods Mol Biol. 2022;2445:75-98. doi: 10.1007/978-1-0716-2071-7_6. PubMed |
| Measuring Autophagic Cargo Flux with Keima-Based Probes. Engedal N, Sonstevold T, Beese CJ, Selladurai S, Melcher T, Simensen JE, Frankel LB, Urbanucci A, Torgersen ML. Methods Mol Biol. 2022;2445:99-115. doi: 10.1007/978-1-0716-2071-7_7. PubMed |
| HIF1alpha/HIF2alpha induces glioma cell dedifferentiation into cancer stem cells through Sox2 under hypoxic conditions. Wang P, Gong S, Liao B, Pan J, Wang J, Zou D, Zhao L, Xiong S, Deng Y, Yan Q, Wu N. J Cancer. 2022 Jan 1;13(1):1-14. doi: 10.7150/jca.54402. eCollection 2022. PubMed |
| Specific inhibition of the NLRP3 inflammasome suppresses immune overactivation and alleviates COVID-19 like pathology in mice. Zeng J, Xie X, Feng XL, Xu L, Han JB, Yu D, Zou QC, Liu Q, Li X, Ma G, Li MH, Yao YG. EBioMedicine. 2022 Jan;75:103803. doi: 10.1016/j.ebiom.2021.103803. Epub 2021 Dec 31. PubMed |
| HDLs extract lipophilic drugs from cells. Zheng A, Dubuis G, Georgieva M, Mendes Ferreira CS, Serulla M, Del Carmen Conde Rubio M, Trofimenko E, Mercier T, Decosterd L, Widmann C. J Cell Sci. 2022 Mar 1;135(5):jcs258644. doi: 10.1242/jcs.258644. Epub 2022 Jan 31. PubMed |
| Enhancing the HSV-1-mediated antitumor immune response by suppressing Bach1. Pan C, Cai Q, Li X, Li L, Yang L, Chen Y, Liu J, Liu W, Gao M, Sui T, Wang X, Fan H, Ruan J, Shi Y, Chen S, Cheng LS, Liu J, Yang H, Cheng G. Cell Mol Immunol. 2022 Apr;19(4):516-526. doi: 10.1038/s41423-021-00824-3. Epub 2022 Jan 5. PubMed |
| Insulin sensitivity in the aged heart is improved by down-regulation of KAT7 in vivo and in vitro. Wang B, Li J, Liu L, Song G. Cell Cycle. 2022 Feb;21(3):276-288. doi: 10.1080/15384101.2021.2018811. Epub 2022 Jan 6. PubMed |
| PIP3 abundance overcomes PI3K signaling selectivity in invadopodia. Jakubik CT, Weckerly CC, Hammond GRV, Bresnick AR, Backer JM. FEBS Lett. 2022 Feb;596(4):417-426. doi: 10.1002/1873-3468.14273. Epub 2022 Jan 12. PubMed |
| A bivalent nanoparticle vaccine exhibits potent cross-protection against the variants of SARS-CoV-2. Yuan Y, Zhang X, Chen R, Li Y, Wu B, Li R, Zou F, Ma X, Wang X, Chen Q, Deng J, Zhang Y, Chen T, Lin Y, Yan S, Zhang X, Li C, Bu X, Peng Y, Ke C, Deng K, Pan T, He X, Zhang Y, Zhang H. Cell Rep. 2022 Jan 18;38(3):110256. doi: 10.1016/j.celrep.2021.110256. Epub 2021 Dec 23. PubMed |
| Multilayer microfluidic platform for the study of luminal, transmural, and interstitial flow. Lee GH, Huang SA, Aw WY, Rathod ML, Cho C, Ligler FS, Polacheck WJ. Biofabrication. 2022 Jan 25;14(2). doi: 10.1088/1758-5090/ac48e5. PubMed |
| C2cd6-encoded CatSpertau targets sperm calcium channel to Ca(2+) signaling domains in the flagellar membrane. Hwang JY, Wang H, Lu Y, Ikawa M, Chung JJ. Cell Rep. 2022 Jan 18;38(3):110226. doi: 10.1016/j.celrep.2021.110226. Epub 2022 Jan 7. PubMed |
| Circadian disruption and cisplatin chronotherapy for mammary carcinoma. Koritala BSC, Porter KI, Sarkar S, Gaddameedhi S. Toxicol Appl Pharmacol. 2022 Feb 1;436:115863. doi: 10.1016/j.taap.2022.115863. Epub 2022 Jan 5. PubMed |
| Progerin-expressing endothelial cells are unable to adapt to shear stress. Danielsson BE, Peters HC, Bathula K, Spear LM, Noll NA, Dahl KN, Conway DE. Biophys J. 2022 Feb 15;121(4):620-628. doi: 10.1016/j.bpj.2022.01.004. Epub 2022 Jan 6. PubMed |
| Functional CDKN2A assay identifies frequent deleterious alleles misclassified as variants of uncertain significance. Kimura H, Paranal RM, Nanda N, Wood LD, Eshleman JR, Hruban RH, Goggins MG, Klein AP, Roberts NJ. Elife. 2022 Jan 10;11. pii: 71137. doi: 10.7554/eLife.71137. PubMed |
| A one-step platform for screening high-efficient and minimal off-target CRISPR/Cas13 crRNAs to eradicate SARS-CoV-2 virus for treatment of COVID-19 patients. Li PY, Li SQ, Gao SG, Dong DY. Med Hypotheses. 2022 Feb;159:110754. doi: 10.1016/j.mehy.2021.110754. Epub 2022 Jan 4. PubMed |
| Axl Is Essential for in-vitro Angiogenesis Induced by Vitreous From Patients With Proliferative Diabetic Retinopathy. Wu W, Xu H, Meng Z, Zhu J, Xiong S, Xia X, Lei H. Front Med (Lausanne). 2021 Dec 23;8:787150. doi: 10.3389/fmed.2021.787150. eCollection 2021. PubMed |
| Intracellular IL-32 regulates mitochondrial metabolism, proliferation, and differentiation of malignant plasma cells. Aass KR, Mjelle R, Kastnes MH, Tryggestad SS, van den Brink LM, Aass Roseth I, Westhrin M, Zahoor M, Moen SH, Vikene Nedal TM, Buene G, Misund K, Sponaas AM, Ma Q, Sundan A, Groen RW, Slordahl TS, Waage A, Standal T. iScience. 2021 Dec 13;25(1):103605. doi: 10.1016/j.isci.2021.103605. eCollection 2022 Jan 21. PubMed |
| A bispecific monomeric nanobody induces spike trimer dimers and neutralizes SARS-CoV-2 in vivo. Hanke L, Das H, Sheward DJ, Perez Vidakovics L, Urgard E, Moliner-Morro A, Kim C, Karl V, Pankow A, Smith NL, Porebski B, Fernandez-Capetillo O, Sezgin E, Pedersen GK, Coquet JM, Hallberg BM, Murrell B, McInerney GM. Nat Commun. 2022 Jan 10;13(1):155. doi: 10.1038/s41467-021-27610-z. PubMed |
| BCOR and BCORL1 Mutations Drive Epigenetic Reprogramming and Oncogenic Signaling by Unlinking PRC1.1 from Target Genes. Schaefer EJ, Wang HC, Karp HQ, Meyer CA, Cejas P, Gearhart MD, Adelman ER, Fares I, Apffel A, Lim K, Xie Y, Gibson CJ, Schenone M, Murdock HM, Wang ES, Gondek LP, Carroll MP, Vedula RS, Winer ES, Garcia JS, Stone RM, Luskin MR, Carr SA, Long HW, Bardwell VJ, Figueroa ME, Lindsley RC. Blood Cancer Discov. 2022 Mar 1;3(2):116-135. doi: 10.1158/2643-3230.BCD-21-0115. PubMed |
| Identification and functional characterization of transcriptional activators in human cells. Alerasool N, Leng H, Lin ZY, Gingras AC, Taipale M. Mol Cell. 2022 Feb 3;82(3):677-695.e7. doi: 10.1016/j.molcel.2021.12.008. Epub 2022 Jan 10. PubMed |
| The metabolic stress-activated checkpoint LKB1-MARK3 axis acts as a tumor suppressor in high-grade serous ovarian carcinoma. Machino H, Kaneko S, Komatsu M, Ikawa N, Asada K, Nakato R, Shozu K, Dozen A, Sone K, Yoshida H, Kato T, Oda K, Osuga Y, Fujii T, von Keudell G, Saloura V, Hamamoto R. Commun Biol. 2022 Jan 11;5(1):39. doi: 10.1038/s42003-021-02992-4. PubMed |
| SCP4-STK35/PDIK1L complex is a dual phospho-catalytic signaling dependency in acute myeloid leukemia. Polyanskaya SA, Moreno RY, Lu B, Feng R, Yao Y, Irani S, Klingbeil O, Yang Z, Wei Y, Demerdash OE, Benjamin LA, Weiss MJ, Zhang YJ, Vakoc CR. Cell Rep. 2022 Jan 11;38(2):110233. doi: 10.1016/j.celrep.2021.110233. PubMed |
| Lysoptosis is an evolutionarily conserved cell death pathway moderated by intracellular serpins. Luke CJ, Markovina S, Good M, Wight IE, Thomas BJ, Linneman JM, Lanik WE, Koroleva O, Coffman MR, Miedel MT, Gong Q, Andress A, Campos Guerrero M, Wang S, Chen L, Beatty WL, Hausmann KN, White FV, Fitzpatrick JAJ, Orvedahl A, Pak SC, Silverman GA. Commun Biol. 2022 Jan 12;5(1):47. doi: 10.1038/s42003-021-02953-x. PubMed |
| SARS-CoV-2 membrane protein causes the mitochondrial apoptosis and pulmonary edema via targeting BOK. Yang Y, Wu Y, Meng X, Wang Z, Younis M, Liu Y, Wang P, Huang X. Cell Death Differ. 2022 Jul;29(7):1395-1408. doi: 10.1038/s41418-022-00928-x. Epub 2022 Jan 12. PubMed |
| Mitochondria shed their outer membrane in response to infection-induced stress. Li X, Straub J, Medeiros TC, Mehra C, den Brave F, Peker E, Atanassov I, Stillger K, Michaelis JB, Burbridge E, Adrain C, Munch C, Riemer J, Becker T, Pernas LF. Science. 2022 Jan 14;375(6577):eabi4343. doi: 10.1126/science.abi4343. Epub 2022 Jan 14. PubMed |
| RECON syndrome is a genome instability disorder caused by mutations in the DNA helicase RECQL1. Abu-Libdeh B, Jhujh SS, Dhar S, Sommers JA, Datta A, Longo GM, Grange LJ, Reynolds JJ, Cooke SL, McNee GS, Hollingworth R, Woodward BL, Ganesh AN, Smerdon SJ, Nicolae CM, Durlacher-Betzer K, Molho-Pessach V, Abu-Libdeh A, Meiner V, Moldovan GL, Roukos V, Harel T, Brosh RM Jr, Stewart GS. J Clin Invest. 2022 Mar 1;132(5). pii: 147301. doi: 10.1172/JCI147301. PubMed |
| SARS-CoV-2 mRNA vaccination elicits a robust and persistent T follicular helper cell response in humans. Mudd PA, Minervina AA, Pogorelyy MV, Turner JS, Kim W, Kalaidina E, Petersen J, Schmitz AJ, Lei T, Haile A, Kirk AM, Mettelman RC, Crawford JC, Nguyen THO, Rowntree LC, Rosati E, Richards KA, Sant AJ, Klebert MK, Suessen T, Middleton WD, Wolf J, Teefey SA, O'Halloran JA, Presti RM, Kedzierska K, Rossjohn J, Thomas PG, Ellebedy AH. Cell. 2022 Feb 17;185(4):603-613.e15. doi: 10.1016/j.cell.2021.12.026. Epub 2021 Dec 23. PubMed |
| Spindle pole body component 24 homolog potentiates tumor progression via regulation of SRY-box transcription factor 2 in clear cell renal cell carcinoma. Sun C, Wei J, Long Z, Zhao W, Huangfu Q, Xie Q, Wang B, Wen J. FASEB J. 2022 Feb;36(2):e22086. doi: 10.1096/fj.202101310R. PubMed |
| Using genetically modified extracellular vesicles as a non-invasive strategy to evaluate brain-specific cargo. Rufino-Ramos D, Lule S, Mahjoum S, Ughetto S, Cristopher Bragg D, Pereira de Almeida L, Breakefield XO, Breyne K. Biomaterials. 2022 Feb;281:121366. doi: 10.1016/j.biomaterials.2022.121366. Epub 2022 Jan 8. PubMed |
| Innate-like NKp30(+)CD8(+) T cells armed with TCR/CAR target tumor heterogeneity. Correia MP, Stojanovic A, Wels WS, Cerwenka A. Oncoimmunology. 2021 Oct 19;10(1):1973783. doi: 10.1080/2162402X.2021.1973783. eCollection 2021. PubMed |
| V-CARMA: A tool for the detection and modification of antigen-specific T cells. Guo XJ, Elledge SJ. Proc Natl Acad Sci U S A. 2022 Jan 25;119(4). pii: 2116277119. doi: 10.1073/pnas.2116277119. PubMed |
| Impaired catabolism of free oligosaccharides due to MAN2C1 variants causes a neurodevelopmental disorder. Maia N, Potelle S, Yildirim H, Duvet S, Akula SK, Schulz C, Wiame E, Gheldof A, O'Kane K, Lai A, Sermon K, Proisy M, Loget P, Attie-Bitach T, Quelin C, Fortuna AM, Soares AR, de Brouwer APM, Van Schaftingen E, Nassogne MC, Walsh CA, Stouffs K, Jorge P, Jansen AC, Foulquier F. Am J Hum Genet. 2022 Feb 3;109(2):345-360. doi: 10.1016/j.ajhg.2021.12.010. Epub 2022 Jan 18. PubMed |
| Identification of the Cysteine Protease Legumain as a Potential Chronic Hypoxia-Specific Multiple Myeloma Target Gene. Clees AS, Stolp V, Haupl B, Fuhrmann DC, Wempe F, Seibert M, Weber S, Banning A, Tikkanen R, Williams R, Brune B, Serve H, Schnutgen F, von Metzler I, Kurrle N. Cells. 2022 Jan 15;11(2). pii: cells11020292. doi: 10.3390/cells11020292. PubMed |
| STAT3 Enhances Sensitivity of Glioblastoma to Drug-Induced Autophagy-Dependent Cell Death. Remy J, Linder B, Weirauch U, Day BW, Stringer BW, Herold-Mende C, Aigner A, Krohn K, Kogel D. Cancers (Basel). 2022 Jan 11;14(2). pii: cancers14020339. doi: 10.3390/cancers14020339. PubMed |
| XRCC4 and MRE11 Roles and Transcriptional Response to Repair of TALEN-Induced Double-Strand DNA Breaks. Benjamin R, Banerjee A, Wu X, Geurink C, Buczek L, Eames D, Trimidal SG, Pluth JM, Schiller MR. Int J Mol Sci. 2022 Jan 6;23(2). pii: ijms23020593. doi: 10.3390/ijms23020593. PubMed |
| Impact of Formulation Conditions on Lipid Nanoparticle Characteristics and Functional Delivery of CRISPR RNP for Gene Knock-Out and Correction. Walther J, Wilbie D, Tissingh VSJ, Oktem M, van der Veen H, Lou B, Mastrobattista E. Pharmaceutics. 2022 Jan 17;14(1):213. doi: 10.3390/pharmaceutics14010213. PubMed |
| PGK1 represses autophagy-mediated cell death to promote the proliferation of liver cancer cells by phosphorylating PRAS40. Zhang T, Wang Y, Yu H, Zhang T, Guo L, Xu J, Wei X, Wang N, Wu Y, Wang X, Huang L. Cell Death Dis. 2022 Jan 20;13(1):68. doi: 10.1038/s41419-022-04499-0. PubMed |
| Modeling SARS-CoV-2 Infection in Mice Using Lentiviral hACE2 Vectors Infers Two Modes of Immune Responses to SARS-CoV-2 Infection. Katzman C, Israely T, Melamed S, Politi B, Sittner A, Yahalom-Ronen Y, Weiss S, Abu Rass R, Zamostiano R, Bacharach E, Ehrlich M, Paran N, Nissim L. Viruses. 2021 Dec 21;14(1). pii: v14010011. doi: 10.3390/v14010011. PubMed |
| Photodynamic Inactivation of Human Coronaviruses. Duguay BA, Herod A, Pringle ES, Monro SMA, Hetu M, Cameron CG, McFarland SA, McCormick C. Viruses. 2022 Jan 8;14(1). pii: v14010110. doi: 10.3390/v14010110. PubMed |
| Simulation of Molecular Dynamics of SARS-CoV-2 S-Protein in the Presence of Multiple Arbidol Molecules: Interactions and Binding Mode Insights. Borisevich SS, Khamitov EM, Gureev MA, Yarovaya OI, Rudometova NB, Zybkina AV, Mordvinova ED, Shcherbakov DN, Maksyutov RA, Salakhutdinov NF. Viruses. 2022 Jan 10;14(1). pii: v14010119. doi: 10.3390/v14010119. PubMed |
| KIR2DL4 promotes the proliferation of RCC cell associated with PI3K/Akt signaling activation. Ding XF, Chen J, Ma HL, Liang Y, Wang YF, Zhang HT, Li X, Chen G. Life Sci. 2022 Mar 15;293:120320. doi: 10.1016/j.lfs.2022.120320. Epub 2022 Jan 19. PubMed |
| JAM-A interacts with alpha3beta1 integrin and tetraspanins CD151 and CD9 to regulate collective cell migration of polarized epithelial cells. Tholmann S, Seebach J, Otani T, Florin L, Schnittler H, Gerke V, Furuse M, Ebnet K. Cell Mol Life Sci. 2022 Jan 24;79(2):88. doi: 10.1007/s00018-022-04140-5. PubMed |
| Golgi phosphoprotein 3 promotes angiogenesis and sorafenib resistance in hepatocellular carcinoma via upregulating exosomal miR-494-3p. Gao Y, Yin Z, Qi Y, Peng H, Ma W, Wang R, Li W. Cancer Cell Int. 2022 Jan 24;22(1):35. doi: 10.1186/s12935-022-02462-9. PubMed |
| Nucleotide biosynthesis links glutathione metabolism to ferroptosis sensitivity. Tarangelo A, Rodencal J, Kim JT, Magtanong L, Long JZ, Dixon SJ. Life Sci Alliance. 2022 Jan 24;5(4):e202101157. doi: 10.26508/lsa.202101157. Print 2022 Apr. PubMed |
| ER stress-induced cell death proceeds independently of the TRAIL-R2 signaling axis in pancreatic beta cells. Hagenlocher C, Siebert R, Taschke B, Wieske S, Hausser A, Rehm M. Cell Death Discov. 2022 Jan 24;8(1):34. doi: 10.1038/s41420-022-00830-y. PubMed |
| Identification of a STIM1 Splicing Variant that Promotes Glioblastoma Growth. Xie J, Ma G, Zhou L, He L, Zhang Z, Tan P, Huang Z, Fang S, Wang T, Lee YT, Wen S, Siwko S, Wang L, Liu J, Du Y, Zhang N, Liu X, Han L, Huang Y, Wang R, Wang Y, Zhou Y, Han W. Adv Sci (Weinh). 2022 Apr;9(11):e2103940. doi: 10.1002/advs.202103940. Epub 2022 Jan 25. PubMed |
| Systematic decomposition of sequence determinants governing CRISPR/Cas9 specificity. Fu R, He W, Dou J, Villarreal OD, Bedford E, Wang H, Hou C, Zhang L, Wang Y, Ma D, Chen Y, Gao X, Depken M, Xu H. Nat Commun. 2022 Jan 25;13(1):474. doi: 10.1038/s41467-022-28028-x. PubMed |
| Parallel functional assessment of m(6)A sites in human endodermal differentiation with base editor screens. Cheng W, Liu F, Ren Z, Chen W, Chen Y, Liu T, Ma Y, Cao N, Wang J. Nat Commun. 2022 Jan 25;13(1):478. doi: 10.1038/s41467-022-28106-0. PubMed |
| Disruption of actin dynamics induces autophagy of the eukaryotic chaperonin TRiC/CCT. Date Y, Matsuura A, Itakura E. Cell Death Discov. 2022 Jan 25;8(1):37. doi: 10.1038/s41420-022-00828-6. PubMed |
scDART-seq reveals distinct m(6)A signatures and mRNA methylation heterogeneity in single cells.
Tegowski M, Flamand MN, Meyer KD.
Mol Cell. 2022 Feb 17;82(4):868-878.e10. doi: 10.1016/j.molcel.2021.12.038. Epub 2022 Jan 25.
PubMed
Associated Plasmids |
| Genome-scale CRISPR screens identify host factors that promote human coronavirus infection. Grodzki M, Bluhm AP, Schaefer M, Tagmount A, Russo M, Sobh A, Rafiee R, Vulpe CD, Karst SM, Norris MH. Genome Med. 2022 Jan 27;14(1):10. doi: 10.1186/s13073-022-01013-1. PubMed |
| Functional Genomic Identification of Predictors of Sensitivity and Mechanisms of Resistance to Multivalent Second-Generation TRAIL-R2 Agonists. Grinkevitch V, Wappett M, Crawford N, Price S, Lees A, McCann C, McAllister K, Prehn J, Young J, Bateson J, Gallagher L, Michaut M, Iyer V, Chatzipli A, Barthorpe S, Ciznadija D, Sloma I, Wesa A, Tice DA, Wessels L, Garnett M, Longley DB, McDermott U, McDade SS. Mol Cancer Ther. 2022 Apr 1;21(4):594-606. doi: 10.1158/1535-7163.MCT-21-0532. PubMed |
| Prenatal Cadmium Exposure Alters Proliferation in Mouse CD4(+) T Cells via LncRNA Snhg7. McCall JL, Varney ME, Rice E, Dziadowicz SA, Hall C, Blethen KE, Hu G, Barnett JB, Martinez I. Front Immunol. 2022 Jan 11;12:720635. doi: 10.3389/fimmu.2021.720635. eCollection 2021. PubMed |
| Discoidin domain receptor 1 promotes hepatocellular carcinoma progression through modulation of SLC1A5 and the mTORC1 signaling pathway. Pan Y, Han M, Zhang X, He Y, Yuan C, Xiong Y, Li X, Zeng C, Lu K, Zhu H, Lu X, Liu Q, Liang H, Liao Z, Ding Z, Zhang Z, Chen X, Zhang W, Zhang B. Cell Oncol (Dordr). 2022 Feb;45(1):163-178. doi: 10.1007/s13402-022-00659-8. Epub 2022 Jan 28. PubMed |
| The SH2 domain and kinase activity of JAK2 target JAK2 to centrosome and regulate cell growth and centrosome amplification. Shahi A, Kahle J, Hopkins C, Diakonova M. PLoS One. 2022 Jan 28;17(1):e0261098. doi: 10.1371/journal.pone.0261098. eCollection 2022. PubMed |
| LncRNAs LCETRL3 and LCETRL4 at chromosome 4q12 diminish EGFR-TKIs efficiency in NSCLC through stabilizing TDP43 and EIF2S1. Li Y, Shen Y, Xie M, Wang B, Wang T, Zeng J, Hua H, Yu J, Yang M. Signal Transduct Target Ther. 2022 Jan 31;7(1):30. doi: 10.1038/s41392-021-00847-2. PubMed |
| Mesenchymal Stem Cells Derived Extracellular Vesicles Alleviate Traumatic Hemorrhagic Shock Induced Hepatic Injury via IL-10/PTPN22-Mediated M2 Kupffer Cell Polarization. Zhang Y, Zhang X, Zhang H, Song P, Pan W, Xu P, Wang G, Hu P, Wang Z, Huang K, Zhang X, Wang H, Zhang J. Front Immunol. 2022 Jan 12;12:811164. doi: 10.3389/fimmu.2021.811164. eCollection 2021. PubMed |
| m6A modifications regulate intestinal immunity and rotavirus infection. Wang A, Tao W, Tong J, Gao J, Wang J, Hou G, Qian C, Zhang G, Li R, Wang D, Ren X, Zhang K, Ding S, Flavell RA, Li H, Pan W, Zhu S. Elife. 2022 Jan 31;11. pii: 73628. doi: 10.7554/eLife.73628. PubMed |
| ALFY localizes to early endosomes and cellular protrusions to facilitate directional cell migration. Soreng K, Pankiv S, Bergsmark C, Haugsten EM, Dahl AK, de la Ballina LR, Yamamoto A, Lystad AH, Simonsen A. J Cell Sci. 2022 Feb 15;135(4):jcs259138. doi: 10.1242/jcs.259138. Epub 2022 Feb 18. PubMed |
| Aberrant expression of claudin-6 contributes to malignant potentials and drug resistance of cervical adenocarcinoma. Ito Y, Takasawa A, Takasawa K, Murakami T, Akimoto T, Kyuno D, Kawata Y, Shano K, Kirisawa K, Ota M, Aoyama T, Murata M, Sugimoto K, Chiba H, Saito T, Osanai M. Cancer Sci. 2022 Apr;113(4):1519-1530. doi: 10.1111/cas.15284. Epub 2022 Feb 13. PubMed |
| Splicing is an alternate oncogenic pathway activation mechanism in glioma. Siddaway R, Milos S, Vadivel AKA, Dobson THW, Swaminathan J, Ryall S, Pajovic S, Patel PG, Nazarian J, Becher O, Brudno M, Ramani A, Gopalakrishnan V, Hawkins C. Nat Commun. 2022 Jan 31;13(1):588. doi: 10.1038/s41467-022-28253-4. PubMed |
| RNA-binding protein complex LIN28/MSI2 enhances cancer stem cell-like properties by modulating Hippo-YAP1 signaling and independently of Let-7. Zou H, Luo J, Guo Y, Liu Y, Wang Y, Deng L, Li P. Oncogene. 2022 Mar;41(11):1657-1672. doi: 10.1038/s41388-022-02198-w. Epub 2022 Jan 31. PubMed |
| Time-resolved single-cell sequencing identifies multiple waves of mRNA decay during the mitosis-to-G1 phase transition. Krenning L, Sonneveld S, Tanenbaum M. Elife. 2022 Feb 1;11. pii: 71356. doi: 10.7554/eLife.71356. PubMed |
| Evaluation of immunosuppression protocols for MHC-matched allogeneic iPS cell-based transplantation using a mouse skin transplantation model. Kamatani T, Otsuka R, Murata T, Wada H, Takahashi T, Mori A, Murata S, Taniguchi H, Seino KI. Inflamm Regen. 2022 Feb 2;42(1):4. doi: 10.1186/s41232-021-00190-7. PubMed |
| Roles of receptor-interacting protein kinase 1 in SH-SY5Y cells with beta amyloid-induced neurotoxicity. Chan HH, Leong CO, Lim CL, Koh RY. J Cell Mol Med. 2022 Mar;26(5):1434-1444. doi: 10.1111/jcmm.17095. Epub 2022 Feb 2. PubMed |
| Gene silencing by EZH2 suppresses TGF-beta activity within the decidua to avert pregnancy-adverse wound healing at the maternal-fetal interface. Osokine I, Siewiera J, Rideaux D, Ma S, Tsukui T, Erlebacher A. Cell Rep. 2022 Feb 1;38(5):110329. doi: 10.1016/j.celrep.2022.110329. PubMed |
| Generation of individualized immunocompatible endothelial cells from HLA-I-matched human pluripotent stem cells. Song C, Wang L, Li Q, Liao B, Qiao W, Li Q, Dong N, Li L. Stem Cell Res Ther. 2022 Feb 2;13(1):48. doi: 10.1186/s13287-022-02720-7. PubMed |
| BACE2 variant identified from HSCR patient causes AD-like phenotypes in hPSC-derived brain organoids. Luo J, Zou H, Guo Y, Huang K, Ngan ES, Li P. Cell Death Discov. 2022 Feb 2;8(1):47. doi: 10.1038/s41420-022-00845-5. PubMed |
| Engineered bacterial voltage-gated sodium channel platform for cardiac gene therapy. Nguyen HX, Wu T, Needs D, Zhang H, Perelli RM, DeLuca S, Yang R, Tian M, Landstrom AP, Henriquez C, Bursac N. Nat Commun. 2022 Feb 2;13(1):620. doi: 10.1038/s41467-022-28251-6. PubMed |
| Mutational scanning identified amino acids of the CLOCK exon 19-domain essential for circadian rhythms. Abdo AN, Rintisch C, Gabriel CH, Kramer A. Acta Physiol (Oxf). 2022 Apr;234(4):e13794. doi: 10.1111/apha.13794. Epub 2022 Feb 12. PubMed |
Functional visualization of NK Cell-mediated killing of metastatic single tumor cells.
Ichise H, Tsukamoto S, Hirashima T, Konishi Y, Oki C, Tsukiji S, Iwano S, Miyawaki A, Sumiyama K, Terai K, Matsuda M.
Elife. 2022 Feb 3;11. pii: 76269. doi: 10.7554/eLife.76269.
PubMed
Associated Plasmids |
CRISPR activation and interference screens decode stimulation responses in primary human T cells.
Schmidt R, Steinhart Z, Layeghi M, Freimer JW, Bueno R, Nguyen VQ, Blaeschke F, Ye CJ, Marson A.
Science. 2022 Feb 4;375(6580):eabj4008. doi: 10.1126/science.abj4008. Epub 2022 Feb 4.
PubMed
Associated Plasmids |
| Inhibition of BCL2A1 by STAT5 inactivation overcomes resistance to targeted therapies of FLT3-ITD/D835 mutant AML. Yamatani K, Ai T, Saito K, Suzuki K, Hori A, Kinjo S, Ikeo K, Ruvolo V, Zhang W, Mak PY, Kaczkowski B, Harada H, Katayama K, Sugimoto Y, Myslinski J, Hato T, Miida T, Konopleva M, Hayashizaki Y, Carter BZ, Tabe Y, Andreeff M. Transl Oncol. 2022 Apr;18:101354. doi: 10.1016/j.tranon.2022.101354. Epub 2022 Feb 1. PubMed |
| Receptor-interacting protein kinase 2 (RIPK2) stabilizes c-Myc and is a therapeutic target in prostate cancer metastasis. Yan Y, Zhou B, Qian C, Vasquez A, Kamra M, Chatterjee A, Lee YJ, Yuan X, Ellis L, Di Vizio D, Posadas EM, Kyprianou N, Knudsen BS, Shah K, Murali R, Gertych A, You S, Freeman MR, Yang W. Nat Commun. 2022 Feb 3;13(1):669. doi: 10.1038/s41467-022-28340-6. PubMed |
| A novel chimeric antigen receptor (CAR) system using an exogenous protease, in which activation of T cells is controlled by expression patterns of cellsurface proteins on target cells. Aoyama S, Yasuda S, Li H, Watanabe D, Umezawa Y, Okada K, Nogami A, Miura O, Kawamata N. Int J Mol Med. 2022 Apr;49(4). pii: 42. doi: 10.3892/ijmm.2022.5097. Epub 2022 Feb 4. PubMed |
| Pharmacological inhibition of BACE1 suppresses glioblastoma growth by stimulating macrophage phagocytosis of tumor cells. Zhai K, Huang Z, Huang Q, Tao W, Fang X, Zhang A, Li X, Stark GR, Hamilton TA, Bao S. Nat Cancer. 2021 Nov;2(11):1136-1151. doi: 10.1038/s43018-021-00267-9. Epub 2021 Nov 8. PubMed |
| Selective multi-kinase inhibition sensitizes mesenchymal pancreatic cancer to immune checkpoint blockade by remodeling the tumor microenvironment. Falcomata C, Barthel S, Widholz SA, Schneeweis C, Montero JJ, Toska A, Mir J, Kaltenbacher T, Heetmeyer J, Swietlik JJ, Cheng JY, Teodorescu B, Reichert O, Schmitt C, Grabichler K, Coluccio A, Boniolo F, Veltkamp C, Zukowska M, Vargas AA, Paik WH, Jesinghaus M, Steiger K, Maresch R, Ollinger R, Ammon T, Baranov O, Robles MS, Rechenberger J, Kuster B, Meissner F, Reichert M, Flossdorf M, Rad R, Schmidt-Supprian M, Schneider G, Saur D. Nat Cancer. 2022 Mar;3(3):318-336. doi: 10.1038/s43018-021-00326-1. Epub 2022 Jan 31. PubMed |
| Acetate Improves the Killing of Streptococcus pneumoniae by Alveolar Macrophages via NLRP3 Inflammasome and Glycolysis-HIF-1alpha Axis. Machado MG, Patente TA, Rouille Y, Heumel S, Melo EM, Deruyter L, Pourcet B, Sencio V, Teixeira MM, Trottein F. Front Immunol. 2022 Jan 20;13:773261. doi: 10.3389/fimmu.2022.773261. eCollection 2022. PubMed |
| Generation of NKX2.5(GFP) Reporter Human iPSCs and Differentiation Into Functional Cardiac Fibroblasts. Lopez-Muneta L, Linares J, Casis O, Martinez-Ibanez L, Gonzalez Miqueo A, Bezunartea J, Sanchez de la Nava AM, Gallego M, Fernandez-Santos ME, Rodriguez-Madoz JR, Aranguren XL, Fernandez-Aviles F, Segovia JC, Prosper F, Carvajal-Vergara X. Front Cell Dev Biol. 2022 Jan 21;9:797927. doi: 10.3389/fcell.2021.797927. eCollection 2021. PubMed |
| Tousled-like kinase 2 targets ASF1 histone chaperones through client mimicry. Simon B, Lou HJ, Huet-Calderwood C, Shi G, Boggon TJ, Turk BE, Calderwood DA. Nat Commun. 2022 Feb 8;13(1):749. doi: 10.1038/s41467-022-28427-0. PubMed |
| Screening of ETO2-GLIS2-induced Super Enhancers identifies targetable cooperative dependencies in acute megakaryoblastic leukemia. Benbarche S, Lopez CK, Salataj E, Aid Z, Thirant C, Laiguillon MC, Lecourt S, Belloucif Y, Vaganay C, Antonini M, Hu J, da Silva Babinet A, Ndiaye-Lobry D, Pardieu B, Petit A, Puissant A, Chaumeil J, Mercher T, Lobry C. Sci Adv. 2022 Feb 11;8(6):eabg9455. doi: 10.1126/sciadv.abg9455. Epub 2022 Feb 9. PubMed |
| PD-L1 promotes myofibroblastic activation of hepatic stellate cells by distinct mechanisms selective for TGF-beta receptor I versus II. Sun L, Wang Y, Wang X, Navarro-Corcuera A, Ilyas S, Jalan-Sakrikar N, Gan C, Tu X, Shi Y, Tu K, Liu Q, Lou Z, Dong H, Sharpe AH, Shah VH, Kang N. Cell Rep. 2022 Feb 8;38(6):110349. doi: 10.1016/j.celrep.2022.110349. PubMed |
| Characterization of a small molecule inhibitor of disulfide reductases that induces oxidative stress and lethality in lung cancer cells. Johnson FD, Ferrarone J, Liu A, Brandstadter C, Munuganti R, Farnsworth DA, Lu D, Luu J, Sihota T, Jansen S, Nagelberg A, Shi R, Forcina GC, Zhang X, Cheng GSW, Spencer Miko SE, de Rappard-Yuswack G, Sorensen PH, Dixon SJ, Guha U, Becker K, Djaballah H, Somwar R, Varmus H, Morin GB, Lockwood WW. Cell Rep. 2022 Feb 8;38(6):110343. doi: 10.1016/j.celrep.2022.110343. PubMed |
| Combining p53 mRNA nanotherapy with immune checkpoint blockade reprograms the immune microenvironment for effective cancer therapy. Xiao Y, Chen J, Zhou H, Zeng X, Ruan Z, Pu Z, Jiang X, Matsui A, Zhu L, Amoozgar Z, Chen DS, Han X, Duda DG, Shi J. Nat Commun. 2022 Feb 9;13(1):758. doi: 10.1038/s41467-022-28279-8. PubMed |
| DDR1 promotes hepatocellular carcinoma metastasis through recruiting PSD4 to ARF6. Zhang X, Hu Y, Pan Y, Xiong Y, Zhang Y, Han M, Dong K, Song J, Liang H, Ding Z, Zhang X, Zhu H, Liu Q, Lu X, Feng Y, Chen X, Zhang Z, Zhang B. Oncogene. 2022 Mar;41(12):1821-1834. doi: 10.1038/s41388-022-02212-1. Epub 2022 Feb 9. PubMed |
| Upregulation of CD14 in mesenchymal stromal cells accelerates lipopolysaccharide-induced response and enhances antibacterial properties. Hirakawa MP, Tjahjono N, Light YK, Celebi AN, Celebi NN, Chintalapudi P, Butler KS, Branda SS, Krishnakumar R. iScience. 2022 Jan 12;25(2):103759. doi: 10.1016/j.isci.2022.103759. eCollection 2022 Feb 18. PubMed |
| A protease-activatable luminescent biosensor and reporter cell line for authentic SARS-CoV-2 infection. Gerber PP, Duncan LM, Greenwood EJ, Marelli S, Naamati A, Teixeira-Silva A, Crozier TW, Gabaev I, Zhan JR, Mulroney TE, Horner EC, Doffinger R, Willis AE, Thaventhiran JE, Protasio AV, Matheson NJ. PLoS Pathog. 2022 Feb 10;18(2):e1010265. doi: 10.1371/journal.ppat.1010265. eCollection 2022 Feb. PubMed |
| Numb/Notch/PLK1 signaling pathway mediated hyperglycemic memory in pancreatic cancer cell radioresistance and the therapeutic effects of metformin. Zhu D, Xia J, Liu C, Fang C. Cell Signal. 2022 May;93:110268. doi: 10.1016/j.cellsig.2022.110268. Epub 2022 Feb 7. PubMed |
| Cancer-cell-derived GABA promotes beta-catenin-mediated tumour growth and immunosuppression. Huang D, Wang Y, Thompson JW, Yin T, Alexander PB, Qin D, Mudgal P, Wu H, Liang Y, Tan L, Pan C, Yuan L, Wan Y, Li QJ, Wang XF. Nat Cell Biol. 2022 Feb;24(2):230-241. doi: 10.1038/s41556-021-00820-9. Epub 2022 Feb 10. PubMed |
| METTL16 exerts an m(6)A-independent function to facilitate translation and tumorigenesis. Su R, Dong L, Li Y, Gao M, He PC, Liu W, Wei J, Zhao Z, Gao L, Han L, Deng X, Li C, Prince E, Tan B, Qing Y, Qin X, Shen C, Xue M, Zhou K, Chen Z, Xue J, Li W, Qin H, Wu X, Sun M, Nam Y, Chen CW, Huang W, Horne D, Rosen ST, He C, Chen J. Nat Cell Biol. 2022 Feb;24(2):205-216. doi: 10.1038/s41556-021-00835-2. Epub 2022 Feb 10. PubMed |
| Identification of novel HPFH-like mutations by CRISPR base editing that elevate the expression of fetal hemoglobin. Ravi NS, Wienert B, Wyman SK, Bell HW, George A, Mahalingam G, Vu JT, Prasad K, Bandlamudi BP, Devaraju N, Rajendiran V, Syedbasha N, Pai AA, Nakamura Y, Kurita R, Narayanasamy M, Balasubramanian P, Thangavel S, Marepally S, Velayudhan SR, Srivastava A, DeWitt MA, Crossley M, Corn JE, Mohankumar KM. Elife. 2022 Feb 11;11. pii: 65421. doi: 10.7554/eLife.65421. PubMed |
| The Use of Three-Dimensional Cell Culture to Study Apicobasal Polarization and Lumen Formation. Roman-Fernandez A, Sandilands E, Bryant DM. Methods Mol Biol. 2022;2438:439-454. doi: 10.1007/978-1-0716-2035-9_25. PubMed |
| Follistatin promotes LIN28B-mediated supporting cell reprogramming and hair cell regeneration in the murine cochlea. Li XJ, Morgan C, Goff LA, Doetzlhofer A. Sci Adv. 2022 Feb 11;8(6):eabj7651. doi: 10.1126/sciadv.abj7651. Epub 2022 Feb 11. PubMed |
| BRD4770 functions as a novel ferroptosis inhibitor to protect against aortic dissection. Chen Y, Yi X, Huo B, He Y, Guo X, Zhang Z, Zhong X, Feng X, Fang ZM, Zhu XH, Wei X, Jiang DS. Pharmacol Res. 2022 Mar;177:106122. doi: 10.1016/j.phrs.2022.106122. Epub 2022 Feb 8. PubMed |
| DNA methyltransferase 1 (DNMT1) suppresses mitophagy and aggravates heart failure via the microRNA-152-3p/ETS1/RhoH axis. Deng Z, Yao J, Xiao N, Han Y, Wu X, Ci C, Chen K, Geng X. Lab Invest. 2022 Aug;102(8):782-793. doi: 10.1038/s41374-022-00740-8. Epub 2022 Feb 11. PubMed |
| RNA sensing via the RIG-I-like receptor LGP2 is essential for the induction of a type I IFN response in ADAR1 deficiency. Stok JE, Oosenbrug T, Ter Haar LR, Gravekamp D, Bromley CP, Zelenay S, Reis E Sousa C, van der Veen AG. EMBO J. 2022 Mar 15;41(6):e109760. doi: 10.15252/embj.2021109760. Epub 2022 Feb 14. PubMed |
| The transcriptional profile of adipose-derived stromal cells (ASC) mirrors the whitening of adipose tissue with age. Scambi I, Peroni D, Nodari A, Merigo F, Benati D, Boschi F, Mannucci S, Frontini A, Visona S, Sbarbati A, Krampera M, Galie M. Eur J Cell Biol. 2022 Apr;101(2):151206. doi: 10.1016/j.ejcb.2022.151206. Epub 2022 Feb 8. PubMed |
| Tracking of Melanoma Cell Plasticity by Transcriptional Reporters. Vidal A, Redmer T. Int J Mol Sci. 2022 Jan 21;23(3):1199. doi: 10.3390/ijms23031199. PubMed |
| The T850D Phosphomimetic Mutation in the Androgen Receptor Ligand Binding Domain Enhances Recruitment at Activation Function 2. Helsen C, Nguyen T, Vercruysse T, Wouters S, Daelemans D, Voet A, Claessens F. Int J Mol Sci. 2022 Jan 29;23(3). pii: ijms23031557. doi: 10.3390/ijms23031557. PubMed |
Base editing sensor libraries for high-throughput engineering and functional analysis of cancer-associated single nucleotide variants.
Sanchez-Rivera FJ, Diaz BJ, Kastenhuber ER, Schmidt H, Katti A, Kennedy M, Tem V, Ho YJ, Leibold J, Paffenholz SV, Barriga FM, Chu K, Goswami S, Wuest AN, Simon JM, Tsanov KM, Chakravarty D, Zhang H, Leslie CS, Lowe SW, Dow LE.
Nat Biotechnol. 2022 Feb 14. pii: 10.1038/s41587-021-01172-3. doi: 10.1038/s41587-021-01172-3.
PubMed
Associated Plasmids |
| Type III CRISPR-based RNA editing for programmable control of SARS-CoV-2 and human coronaviruses. Lin P, Shen G, Guo K, Qin S, Pu Q, Wang Z, Gao P, Xia Z, Khan N, Jiang J, Xia Q, Wu M. Nucleic Acids Res. 2022 May 6;50(8):e47. doi: 10.1093/nar/gkac016. PubMed |
| Computational identification of clonal cells in single-cell CRISPR screens. Wang Y, Xie S, Armendariz D, Hon GC. BMC Genomics. 2022 Feb 15;23(1):135. doi: 10.1186/s12864-022-08359-1. PubMed |
| Functional genomics elucidates regulatory mechanisms of Parkinson's disease-associated variants. Chen R, Liu J, Li S, Li X, Huo Y, Yao YG, Xiao X, Li M, Luo XJ. BMC Med. 2022 Feb 16;20(1):68. doi: 10.1186/s12916-022-02264-w. PubMed |
| Monitoring Virus-Induced Stress Granule Dynamics Using Long-Term Live-Cell Imaging. Magg V, Klein P, Ruggieri A. Methods Mol Biol. 2022;2428:325-348. doi: 10.1007/978-1-0716-1975-9_20. PubMed |
| KIX domain determines a selective tumor-promoting role for EP300 and its vulnerability in small cell lung cancer. Kim KB, Kabra A, Kim DW, Xue Y, Huang Y, Hou PC, Zhou Y, Miranda LJ, Park JI, Shi X, Bender TP, Bushweller JH, Park KS. Sci Adv. 2022 Feb 18;8(7):eabl4618. doi: 10.1126/sciadv.abl4618. Epub 2022 Feb 16. PubMed |
| TP53 promotes lineage commitment of human embryonic stem cells through ciliogenesis and sonic hedgehog signaling. Sivakumar S, Qi S, Cheng N, Sathe AA, Kanchwala M, Kumar A, Evers BM, Xing C, Yu H. Cell Rep. 2022 Feb 15;38(7):110395. doi: 10.1016/j.celrep.2022.110395. PubMed |
| A non-catalytic scaffolding activity of hexokinase 2 contributes to EMT and metastasis. Blaha CS, Ramakrishnan G, Jeon SM, Nogueira V, Rho H, Kang S, Bhaskar P, Terry AR, Aissa AF, Frolov MV, Patra KC, Brooks Robey R, Hay N. Nat Commun. 2022 Feb 16;13(1):899. doi: 10.1038/s41467-022-28440-3. PubMed |
| Legionella pneumophila regulates host cell motility by targeting Phldb2 with a 14-3-3zeta-dependent protease effector. Song L, Luo J, Wang H, Huang D, Tan Y, Liu Y, Wang Y, Yu K, Zhang Y, Liu X, Li D, Luo ZQ. Elife. 2022 Feb 17;11. pii: 73220. doi: 10.7554/eLife.73220. PubMed |
| Circular RNA ANAPC7 Inhibits Tumor Growth and Muscle Wasting via PHLPP2-AKT-TGF-beta Signaling Axis in Pancreatic Cancer. Shi X, Yang J, Liu M, Zhang Y, Zhou Z, Luo W, Fung KM, Xu C, Bronze MS, Houchen CW, Li M. Gastroenterology. 2022 Jun;162(7):2004-2017.e2. doi: 10.1053/j.gastro.2022.02.017. Epub 2022 Feb 14. PubMed |
| YAP/TAZ drives cell proliferation and tumour growth via a polyamine-eIF5A hypusination-LSD1 axis. Li H, Wu BK, Kanchwala M, Cai J, Wang L, Xing C, Zheng Y, Pan D. Nat Cell Biol. 2022 Mar;24(3):373-383. doi: 10.1038/s41556-022-00848-5. Epub 2022 Feb 17. PubMed |
| Cell migration orchestrates migrasome formation by shaping retraction fibers. Fan C, Shi X, Zhao K, Wang L, Shi K, Liu YJ, Li H, Ji B, Jiu Y. J Cell Biol. 2022 Apr 4;221(4). pii: 213015. doi: 10.1083/jcb.202109168. Epub 2022 Feb 18. PubMed |
| RB1 loss overrides PARP inhibitor sensitivity driven by RNASEH2B loss in prostate cancer. Miao C, Tsujino T, Takai T, Gui F, Tsutsumi T, Sztupinszki Z, Wang Z, Azuma H, Szallasi Z, Mouw KW, Zou L, Kibel AS, Jia L. Sci Adv. 2022 Feb 18;8(7):eabl9794. doi: 10.1126/sciadv.abl9794. Epub 2022 Feb 18. PubMed |
| HOTTIP-dependent R-loop formation regulates CTCF boundary activity and TAD integrity in leukemia. Luo H, Zhu G, Eshelman MA, Fung TK, Lai Q, Wang F, Zeisig BB, Lesperance J, Ma X, Chen S, Cesari N, Cogle C, Chen B, Xu B, Yang FC, So CWE, Qiu Y, Xu M, Huang S. Mol Cell. 2022 Feb 17;82(4):833-851.e11. doi: 10.1016/j.molcel.2022.01.014. PubMed |
| Quantitative Proteomic Analysis of Cervical Cancer Tissues Identifies Proteins Associated With Cancer Progression. Ramirez-Torres A, Gil J, Contreras S, Ramirez G, Valencia-Gonzalez HA, Salazar-Bustamante E, Gomez-Caudillo L, Garcia-Carranca A, Encarnacion-Guevara S. Cancer Genomics Proteomics. 2022 Mar-Apr;19(2):241-258. doi: 10.21873/cgp.20317. PubMed |
| CDK2 Inhibition Enhances Antitumor Immunity by Increasing IFN Response to Endogenous Retroviruses. Chen Y, Cai Q, Pan C, Liu W, Li L, Liu J, Gao M, Li X, Wang L, Rao Y, Yang H, Cheng G. Cancer Immunol Res. 2022 Apr 1;10(4):525-539. doi: 10.1158/2326-6066.CIR-21-0806. PubMed |
| PKP1 and MYC create a feedforward loop linking transcription and translation in squamous cell lung cancer. Boyero L, Martin-Padron J, Farez-Vidal ME, Rodriguez MI, Andrades A, Peinado P, Arenas AM, Ritore-Salazar F, Alvarez-Perez JC, Cuadros M, Medina PP. Cell Oncol (Dordr). 2022 Apr;45(2):323-332. doi: 10.1007/s13402-022-00660-1. Epub 2022 Feb 19. PubMed |
| Genetically encoded BRET-activated photodynamic therapy for the treatment of deep-seated tumors. Shramova EI, Chumakov SP, Shipunova VO, Ryabova AV, Telegin GB, Kabashin AV, Deyev SM, Proshkina GM. Light Sci Appl. 2022 Feb 21;11(1):38. doi: 10.1038/s41377-022-00729-4. PubMed |
| PARK2 regulates eIF4B-driven lymphomagenesis. Kapadia BB, Roychowdhury A, Kayastha F, Nanaji N, Gartenhaus RB. Mol Cancer Res. 2022 Feb 1. pii: 681718. doi: 10.1158/1541-7786.MCR-21-0729. PubMed |
| Melanocortin 1 receptor activation protects against alpha-synuclein pathologies in models of Parkinson's disease. Cai W, Srivastava P, Feng D, Lin Y, Vanderburg CR, Xu Y, Mclean P, Frosch MP, Fisher DE, Schwarzschild MA, Chen X. Mol Neurodegener. 2022 Feb 23;17(1):16. doi: 10.1186/s13024-022-00520-4. PubMed |
| TRACE-seq: A transgenic system for unbiased and non-invasive transcriptome profiling of living cells. Cherbonneau F, Li G, Gokulnath P, Sahu P, Prunevieille A, Kitchen R, Benichou G, Larghero J, Domian I, Das S. iScience. 2022 Jan 25;25(2):103806. doi: 10.1016/j.isci.2022.103806. eCollection 2022 Feb 18. PubMed |
| A novel mechanism for NLRP3 inflammasome activation. Zhang T, Zhao J, Liu T, Cheng W, Wang Y, Ding S, Wang R. Metabol Open. 2022 Jan 22;13:100166. doi: 10.1016/j.metop.2022.100166. eCollection 2022 Mar. PubMed |
| Regulation of influenza A virus infection by Lnc-PINK1-2:5. Pushparaj S, Zhu Z, Huang C, More S, Liang Y, Lin K, Vaddadi K, Liu L. J Cell Mol Med. 2022 Apr;26(8):2285-2298. doi: 10.1111/jcmm.17249. Epub 2022 Feb 24. PubMed |
| SF3B4 promotes ovarian cancer progression by regulating alternative splicing of RAD52. Diao Y, Li Y, Wang Z, Wang S, Li P, Kong B. Cell Death Dis. 2022 Feb 24;13(2):179. doi: 10.1038/s41419-022-04630-1. PubMed |
| ABIN1 is a signal-induced autophagy receptor that attenuates NF-kappaB activation by recognizing linear ubiquitin chains. Shinkawa Y, Imami K, Fuseya Y, Sasaki K, Ohmura K, Ishihama Y, Morinobu A, Iwai K. FEBS Lett. 2022 May;596(9):1147-1164. doi: 10.1002/1873-3468.14323. Epub 2022 Mar 4. PubMed |
| Humoral and Cellular Responses to COVID-19 Vaccines in SARS-CoV-2 Infection-Naive and -Recovered Korean Individuals. Hwang JY, Kim Y, Lee KM, Jang EJ, Woo CH, Hong CU, Choi ST, Xayaheuang S, Jang JG, Ahn JH, Park H. Vaccines (Basel). 2022 Feb 18;10(2). pii: vaccines10020332. doi: 10.3390/vaccines10020332. PubMed |
| Potential Anti-SARS-CoV-2 Activity of Pentosan Polysulfate and Mucopolysaccharide Polysulfate. Zhang F, He P, Rodrigues AL, Jeske W, Tandon R, Bates JT, Bierdeman MA, Fareed J, Dordick J, Linhardt RJ. Pharmaceuticals (Basel). 2022 Feb 21;15(2). pii: ph15020258. doi: 10.3390/ph15020258. PubMed |
| The dual role of p62 in ferroptosis of glioblastoma according to p53 status. Yuan F, Sun Q, Zhang S, Ye L, Xu Y, Deng G, Xu Z, Zhang S, Liu B, Chen Q. Cell Biosci. 2022 Feb 25;12(1):20. doi: 10.1186/s13578-022-00764-z. PubMed |
| YAP regulates an SGK1/mTORC1/SREBP-dependent lipogenic program to support proliferation and tissue growth. Vaidyanathan S, Salmi TM, Sathiqu RM, McConville MJ, Cox AG, Brown KK. Dev Cell. 2022 Mar 28;57(6):719-731.e8. doi: 10.1016/j.devcel.2022.02.004. Epub 2022 Feb 24. PubMed |
| The interactions of CAP and LYN with the insulin signaling transducer CBL play an important role in polycystic ovary syndrome. Shen H, Xu X, Fu Z, Xu C, Wang Y. Metabolism. 2022 Jun;131:155164. doi: 10.1016/j.metabol.2022.155164. Epub 2022 Feb 23. PubMed |
| Effective targeting of breast cancer stem cells by combined inhibition of Sam68 and Rad51. Turdo A, Gaggianesi M, Di Franco S, Veschi V, D'Accardo C, Porcelli G, Lo Iacono M, Pillitteri I, Verona F, Militello G, Zippo A, Poli V, Fagnocchi L, Beyes S, Stella S, Lattanzio R, Faldetta N, Lentini VL, Porcasi R, Pistone G, Bongiorno MR, Stassi G, De Maria R, Todaro M. Oncogene. 2022 Apr;41(15):2196-2209. doi: 10.1038/s41388-022-02239-4. Epub 2022 Feb 25. PubMed |
Mutation-specific reporter for optimization and enrichment of prime editing.
Schene IF, Joore IP, Baijens JHL, Stevelink R, Kok G, Shehata S, Ilcken EF, Nieuwenhuis ECM, Bolhuis DP, van Rees RCM, Spelier SA, van der Doef HPJ, Beekman JM, Houwen RHJ, Nieuwenhuis EES, Fuchs SA.
Nat Commun. 2022 Mar 1;13(1):1028. doi: 10.1038/s41467-022-28656-3.
PubMed
Associated Plasmids |
| ADAP1 promotes latent HIV-1 reactivation by selectively tuning KRAS-ERK-AP-1 T cell signaling-transcriptional axis. Ramirez NP, Lee J, Zheng Y, Li L, Dennis B, Chen D, Challa A, Planelles V, Westover KD, Alto NM, D'Orso I. Nat Commun. 2022 Mar 1;13(1):1109. doi: 10.1038/s41467-022-28772-0. PubMed |
| CD164 is a host factor for lymphocytic choriomeningitis virus entry. Bakkers MJG, Moon-Walker A, Herlo R, Brusic V, Stubbs SH, Hastie KM, Saphire EO, Kirchhausen TL, Whelan SPJ. Proc Natl Acad Sci U S A. 2022 Mar 8;119(10):e2119676119. doi: 10.1073/pnas.2119676119. Epub 2022 Mar 2. PubMed |
| ATAD3A oligomerization promotes neuropathology and cognitive deficits in Alzheimer's disease models. Zhao Y, Hu D, Wang R, Sun X, Ropelewski P, Hubler Z, Lundberg K, Wang Q, Adams DJ, Xu R, Qi X. Nat Commun. 2022 Mar 2;13(1):1121. doi: 10.1038/s41467-022-28769-9. PubMed |
| Synthetic introns enable splicing factor mutation-dependent targeting of cancer cells. North K, Benbarche S, Liu B, Pangallo J, Chen S, Stahl M, Bewersdorf JP, Stanley RF, Erickson C, Cho H, Pineda JMB, Thomas JD, Polaski JT, Belleville AE, Gabel AM, Udy DB, Humbert O, Kiem HP, Abdel-Wahab O, Bradley RK. Nat Biotechnol. 2022 Jul;40(7):1103-1113. doi: 10.1038/s41587-022-01224-2. Epub 2022 Mar 3. PubMed |
NanoLuc reporters identify COL4A5 nonsense mutations susceptible to drug-induced stop codon readthrough.
Omachi K, Kai H, Roberge M, Miner JH.
iScience. 2022 Feb 8;25(3):103891. doi: 10.1016/j.isci.2022.103891. eCollection 2022 Mar 18.
PubMed
Associated Plasmids |
| SLC35E2 promoter mutation as a prognostic marker of esophageal squamous cell carcinoma. Li Y, Feng R, Yu X, Li L, Liu Y, Zhang R, Chen X, Zhao Y, Liu Z. Life Sci. 2022 May 1;296:120447. doi: 10.1016/j.lfs.2022.120447. Epub 2022 Mar 2. PubMed |
| Concurrent Inhibition of ERK and Farnesyltransferase Suppresses the Growth of HRAS Mutant Head and Neck Squamous Cell Carcinoma. Javaid S, Schaefer A, Goodwin CM, Nguyen VV, Massey FL, Pierobon M, Gambrell-Sanders D, Waters AM, Lambert KN, Diehl JN, Hobbs GA, Wood KC, Petricoin EF, Der CJ, Cox AD. Mol Cancer Ther. 2022 May 4;21(5):762-774. doi: 10.1158/1535-7163.MCT-21-0142. PubMed |
| Integrin Beta 4E Promotes Endothelial Phenotypic Changes and Attenuates Lung Endothelial Cell Inflammatory Responses. Chen W, Gard JMC, Epshtein Y, Camp SM, Garcia JGN, Jacobson JR, Cress AE. Front Physiol. 2022 Feb 18;13:769325. doi: 10.3389/fphys.2022.769325. eCollection 2022. PubMed |
| Farnesoid X Receptor Deficiency Induces Hepatic Lipid and Glucose Metabolism Disorder via Regulation of Pyruvate Dehydrogenase Kinase 4. Deng W, Fan W, Tang T, Wan H, Zhao S, Tan Y, Oware KA, Tan J, Li J, Qu S. Oxid Med Cell Longev. 2022 Feb 24;2022:3589525. doi: 10.1155/2022/3589525. eCollection 2022. PubMed |
| Synergistic action of WDR5 and HDM2 inhibitors in SMARCB1-deficient cancer cells. Florian AC, Woodley CM, Wang J, Grieb BC, Slota MJ, Guerrazzi K, Hsu CY, Matlock BK, Flaherty DK, Lorey SL, Fesik SW, Howard GC, Liu Q, Weissmiller AM, Tansey WP. NAR Cancer. 2022 Mar 3;4(1):zcac007. doi: 10.1093/narcan/zcac007. eCollection 2022 Mar. PubMed |
| Confined migration promotes cancer metastasis through resistance to anoikis and increased invasiveness. Fanfone D, Wu Z, Mammi J, Berthenet K, Neves D, Weber K, Halaburkova A, Virard F, Bunel F, Jamard C, Hernandez-Vargas H, Tait SWG, Hennino A, Ichim G. Elife. 2022 Mar 8;11. pii: 73150. doi: 10.7554/eLife.73150. PubMed |
| Transiently expressed CRISPR/Cas9 induces wild-type dystrophin in vitro in DMD patient myoblasts carrying duplications. Pini V, Mariot V, Dumonceaux J, Counsell J, O'Neill HC, Farmer S, Conti F, Muntoni F. Sci Rep. 2022 Mar 8;12(1):3756. doi: 10.1038/s41598-022-07671-w. PubMed |
Human epigenetic and transcriptional T cell differentiation atlas for identifying functional T cell-specific enhancers.
Giles JR, Manne S, Freilich E, Oldridge DA, Baxter AE, George S, Chen Z, Huang H, Chilukuri L, Carberry M, Giles L, Weng NP, Young RM, June CH, Schuchter LM, Amaravadi RK, Xu X, Karakousis GC, Mitchell TC, Huang AC, Shi J, Wherry EJ.
Immunity. 2022 Mar 8;55(3):557-574.e7. doi: 10.1016/j.immuni.2022.02.004.
PubMed
Associated Plasmids |
| Targeted intracellular delivery of Cas13 and Cas9 nucleases using bacterial toxin-based platforms. Tian S, Liu Y, Appleton E, Wang H, Church GM, Dong M. Cell Rep. 2022 Mar 8;38(10):110476. doi: 10.1016/j.celrep.2022.110476. PubMed |
| Characterization of SARS-CoV-2 Variants B.1.617.1 (Kappa), B.1.617.2 (Delta), and B.1.618 by Cell Entry and Immune Evasion. Ren W, Ju X, Gong M, Lan J, Yu Y, Long Q, Kenney DJ, O'Connell AK, Zhang Y, Zhong J, Zhong G, Douam F, Wang X, Huang A, Zhang R, Ding Q. mBio. 2022 Apr 26;13(2):e0009922. doi: 10.1128/mbio.00099-22. Epub 2022 Mar 10. PubMed |
| Novel mutation of SIK1 gene causing a mild form of pediatric epilepsy in a Chinese patient. Xu W, Zhang W, Cui L, Shi L, Zhu B, Lyu TJ, Ma W. Metab Brain Dis. 2022 Apr;37(4):1207-1219. doi: 10.1007/s11011-022-00943-4. Epub 2022 Mar 10. PubMed |
| Loxl3 Promotes Melanoma Progression and Dissemination Influencing Cell Plasticity and Survival. Vazquez-Naharro A, Bustos-Tauler J, Floristan A, Yuste L, Oltra SS, Vinyals A, Moreno-Bueno G, Fabra A, Portillo F, Cano A, Santamaria PG. Cancers (Basel). 2022 Feb 25;14(5):1200. doi: 10.3390/cancers14051200. PubMed |
| Role of the Skin Microenvironment in Melanomagenesis: Epidermal Keratinocytes and Dermal Fibroblasts Promote BRAF Oncogene-Induced Senescence Escape in Melanocytes. Sadangi S, Milosavljevic K, Castro-Perez E, Lares M, Singh M, Altameemi S, Beebe DJ, Ayuso JM, Setaluri V. Cancers (Basel). 2022 Feb 27;14(5). pii: cancers14051233. doi: 10.3390/cancers14051233. PubMed |
| Contribution of Endothelial Laminin-Binding Integrins to Cellular Processes Associated with Angiogenesis. Xu H, LaFlamme SE. Cells. 2022 Feb 26;11(5):816. doi: 10.3390/cells11050816. PubMed |
| Immunoproteasome Activity in Chronic Lymphocytic Leukemia as a Target of the Immunoproteasome-Selective Inhibitors. Besse A, Kraus M, Mendez-Lopez M, Maurits E, Overkleeft HS, Driessen C, Besse L. Cells. 2022 Mar 1;11(5). pii: cells11050838. doi: 10.3390/cells11050838. PubMed |
| RNAi-Mediated Screen of Primary AML Cells Nominates MDM4 as a Therapeutic Target in NK-AML with DNMT3A Mutations. Sidorova OA, Sayed S, Paszkowski-Rogacz M, Seifert M, Camgoz A, Roeder I, Bornhauser M, Thiede C, Buchholz F. Cells. 2022 Mar 2;11(5). pii: cells11050854. doi: 10.3390/cells11050854. PubMed |
| MESH1 knockdown triggers proliferation arrest through TAZ repression. Sun T, Ding CC, Zhang Y, Zhang Y, Lin CC, Wu J, Setayeshpour Y, Coggins S, Shepard C, Macias E, Kim B, Zhou P, Gordan R, Chi JT. Cell Death Dis. 2022 Mar 10;13(3):221. doi: 10.1038/s41419-022-04663-6. PubMed |
| In vivo anti-tumor effect of PARP inhibition in IDH1/2 mutant MDS/AML resistant to targeted inhibitors of mutant IDH1/2. Gbyli R, Song Y, Liu W, Gao Y, Biancon G, Chandhok NS, Wang X, Fu X, Patel A, Sundaram R, Tebaldi T, Mamillapalli P, Zeidan AM, Flavell RA, Prebet T, Bindra RS, Halene S. Leukemia. 2022 May;36(5):1313-1323. doi: 10.1038/s41375-022-01536-x. Epub 2022 Mar 10. PubMed |
| H-ABC- and dystonia-causing TUBB4A mutations show distinct pathogenic effects. Krajka V, Vulinovic F, Genova M, Tanzer K, Jijumon AS, Bodakuntla S, Tennstedt S, Mueller-Fielitz H, Meier B, Janke C, Klein C, Rakovic A. Sci Adv. 2022 Mar 11;8(10):eabj9229. doi: 10.1126/sciadv.abj9229. Epub 2022 Mar 11. PubMed |
| Predicting base editing outcomes using position-specific sequence determinants. Pallaseni A, Peets EM, Koeppel J, Weller J, Vanderstichele T, Ho UL, Crepaldi L, van Leeuwen J, Allen F, Parts L. Nucleic Acids Res. 2022 Apr 8;50(6):3551-3564. doi: 10.1093/nar/gkac161. PubMed |
| BMAL1 moonlighting as a gatekeeper for LINE1 repression and cellular senescence in primates. Liang C, Ke Q, Liu Z, Ren J, Zhang W, Hu J, Wang Z, Chen H, Xia K, Lai X, Wang Q, Yang K, Li W, Wu Z, Wang C, Yan H, Jiang X, Ji Z, Ma M, Long X, Wang S, Wang H, Sun H, Belmonte JCI, Qu J, Xiang AP, Liu GH. Nucleic Acids Res. 2022 Apr 8;50(6):3323-3347. doi: 10.1093/nar/gkac146. PubMed |
Benchmarking of SpCas9 variants enables deeper base editor screens of BRCA1 and BCL2.
Sangree AK, Griffith AL, Szegletes ZM, Roy P, DeWeirdt PC, Hegde M, McGee AV, Hanna RE, Doench JG.
Nat Commun. 2022 Mar 14;13(1):1318. doi: 10.1038/s41467-022-28884-7.
PubMed
Associated Plasmids |
| Robo4 is constitutively shed by ADAMs from endothelial cells and the shed Robo4 functions to inhibit Slit3-induced angiogenesis. Xiao W, Pinilla-Baquero A, Faulkner J, Song X, Prabhakar P, Qiu H, Moremen KW, Ludwig A, Dempsey PJ, Azadi P, Wang L. Sci Rep. 2022 Mar 14;12(1):4352. doi: 10.1038/s41598-022-08227-8. PubMed |
| A JAM-A-tetraspanin-alphavbeta5 integrin complex regulates contact inhibition of locomotion. Kummer D, Steinbacher T, Tholmann S, Schwietzer MF, Hartmann C, Horenkamp S, Demuth S, Peddibhotla SSD, Brinkmann F, Kemper B, Schnekenburger J, Brandt M, Betz T, Liashkovich I, Kouzel IU, Shahin V, Corvaia N, Rottner K, Tarbashevich K, Raz E, Greune L, Schmidt MA, Gerke V, Ebnet K. J Cell Biol. 2022 Apr 4;221(4):e202105147. doi: 10.1083/jcb.202105147. Epub 2022 Mar 16. PubMed |
| HSF2 cooperates with HSF1 to drive a transcriptional program critical for the malignant state. Smith RS, Takagishi SR, Amici DR, Metz K, Gayatri S, Alasady MJ, Wu Y, Brockway S, Taiberg SL, Khalatyan N, Taipale M, Santagata S, Whitesell L, Lindquist S, Savas JN, Mendillo ML. Sci Adv. 2022 Mar 18;8(11):eabj6526. doi: 10.1126/sciadv.abj6526. Epub 2022 Mar 16. PubMed |
In vivo prime editing of a metabolic liver disease in mice.
Bock D, Rothgangl T, Villiger L, Schmidheini L, Matsushita M, Mathis N, Ioannidi E, Rimann N, Grisch-Chan HM, Kreutzer S, Kontarakis Z, Kopf M, Thony B, Schwank G.
Sci Transl Med. 2022 Mar 16;14(636):eabl9238. doi: 10.1126/scitranslmed.abl9238. Epub 2022 Mar 16.
PubMed
Associated Plasmids |
| Targeting Glycolysis in Alloreactive T Cells to Prevent Acute Graft-Versus-Host Disease While Preserving Graft-Versus-Leukemia Effect. Huang Y, Zou Y, Jiao Y, Shi P, Nie X, Huang W, Xiong C, Choi M, Huang C, Macintyre AN, Nichols A, Li F, Li CY, MacIver NJ, Cardona DM, Brennan TV, Li Z, Chao NJ, Rathmell JC, Chen BJ. Front Immunol. 2022 Feb 28;13:751296. doi: 10.3389/fimmu.2022.751296. eCollection 2022. PubMed |
| A Novel Bacterial Protease Inhibitor Adjuvant in RBD-Based COVID-19 Vaccine Formulations Containing Alum Increases Neutralizing Antibodies, Specific Germinal Center B Cells and Confers Protection Against SARS-CoV-2 Infection in Mice. Coria LM, Saposnik LM, Pueblas Castro C, Castro EF, Bruno LA, Stone WB, Perez PS, Darriba ML, Chemes LB, Alcain J, Mazzitelli I, Varese A, Salvatori M, Auguste AJ, Alvarez DE, Pasquevich KA, Cassataro J. Front Immunol. 2022 Feb 28;13:844837. doi: 10.3389/fimmu.2022.844837. eCollection 2022. PubMed |
A genome-scale screen for synthetic drivers of T cell proliferation.
Legut M, Gajic Z, Guarino M, Daniloski Z, Rahman JA, Xue X, Lu C, Lu L, Mimitou EP, Hao S, Davoli T, Diefenbach C, Smibert P, Sanjana NE.
Nature. 2022 Mar;603(7902):728-735. doi: 10.1038/s41586-022-04494-7. Epub 2022 Mar 16.
PubMed
Associated Plasmids |
| ATR and CDK4/6 inhibition target the growth of methotrexate-resistant choriocarcinoma. Georgiou M, Ntavelou P, Stokes W, Roy R, Maher GJ, Stoilova T, Choo JAMY, Rakhit CP, Martins M, Ajuh P, Horowitz N, Berkowitz RS, Elias K, Seckl MJ, Pardo OE. Oncogene. 2022 Apr;41(18):2540-2554. doi: 10.1038/s41388-022-02251-8. Epub 2022 Mar 18. PubMed |
| Persistent cell migration emerges from a coupling between protrusion dynamics and polarized trafficking. Vaidziulyte K, Mace AS, Battistella A, Beng W, Schauer K, Coppey M. Elife. 2022 Mar 18;11:e69229. doi: 10.7554/eLife.69229. PubMed |
| Precision analysis of mutant U2AF1 activity reveals deployment of stress granules in myeloid malignancies. Biancon G, Joshi P, Zimmer JT, Hunck T, Gao Y, Lessard MD, Courchaine E, Barentine AES, Machyna M, Botti V, Qin A, Gbyli R, Patel A, Song Y, Kiefer L, Viero G, Neuenkirchen N, Lin H, Bewersdorf J, Simon MD, Neugebauer KM, Tebaldi T, Halene S. Mol Cell. 2022 Mar 17;82(6):1107-1122.e7. doi: 10.1016/j.molcel.2022.02.025. PubMed |
| Estrogen receptor beta promotes endometriosis progression by upregulating CD47 expression in ectopic endometrial stromal cells. Hu L, Zhang J, Lu Y, Fu B, Hu W. J Reprod Immunol. 2022 Jun;151:103513. doi: 10.1016/j.jri.2022.103513. Epub 2022 Mar 14. PubMed |
| PINK1/TAX1BP1-directed mitophagy attenuates vascular endothelial injury induced by copper oxide nanoparticles. Fan Y, Cheng Z, Mao L, Xu G, Li N, Zhang M, Weng P, Zheng L, Dong X, Hu S, Wang B, Qin X, Jiang X, Chen C, Zhang J, Zou Z. J Nanobiotechnology. 2022 Mar 19;20(1):149. doi: 10.1186/s12951-022-01338-4. PubMed |
| Soluble ECM promotes organotypic formation in lung alveolar model. Valdoz JC, Franks NA, Cribbs CG, Jacobs DJ, Dodson EL, Knight CJ, Poulson PD, Garfield SR, Johnson BC, Hemeyer BM, Sudo MT, Saunooke JA, Kartchner BC, Saxton A, Vallecillo-Zuniga ML, Santos M, Chamberlain B, Christensen KA, Nordin GP, Narayanan AS, Raghu G, Van Ry PM. Biomaterials. 2022 Apr;283:121464. doi: 10.1016/j.biomaterials.2022.121464. Epub 2022 Mar 16. PubMed |
| Mechanisms underlying melanoma invasion as a consequence of MLK3 loss. Balinda HU, Sedgwick A, D'Souza-Schorey C. Exp Cell Res. 2022 Jun 1;415(1):113106. doi: 10.1016/j.yexcr.2022.113106. Epub 2022 Mar 18. PubMed |
| SLC35B4 Stabilizes c-MYC Protein by O-GlcNAcylation in HCC. Jiang T, Yang J, Yang H, Chen W, Ji K, Xu Y, Yu L. Front Pharmacol. 2022 Mar 2;13:851089. doi: 10.3389/fphar.2022.851089. eCollection 2022. PubMed |
| The protective role of glucocerebrosidase/ceramide in rheumatoid arthritis. Yang M, Gu J, Xu F, Wang Y, Wang H, Zhang B. Connect Tissue Res. 2022 Mar 21:1-9. doi: 10.1080/03008207.2022.2055552. PubMed |
| Shear stress switches the association of endothelial enhancers from ETV/ETS to KLF transcription factor binding sites. Tsaryk R, Yucel N, Leonard EV, Diaz N, Bondareva O, Odenthal-Schnittler M, Arany Z, Vaquerizas JM, Schnittler H, Siekmann AF. Sci Rep. 2022 Mar 21;12(1):4795. doi: 10.1038/s41598-022-08645-8. PubMed |
| Sense-and-Respond Payload Delivery Using a Novel Antigen-Inducible Promoter Improves Suboptimal CAR-T Activation. Guo T, Ma D, Lu TK. ACS Synth Biol. 2022 Apr 15;11(4):1440-1453. doi: 10.1021/acssynbio.1c00236. Epub 2022 Mar 22. PubMed |
| NOGOB receptor deficiency increases cerebrovascular permeability and hemorrhage via impairing histone acetylation-mediated CCM1/2 expression. Fang Z, Sun X, Wang X, Ma J, Palaia T, Rana U, Miao B, Ragolia L, Hu W, Miao QR. J Clin Invest. 2022 May 2;132(9). pii: 151382. doi: 10.1172/JCI151382. PubMed |
| Viperin triggers ribosome collision-dependent translation inhibition to restrict viral replication. Hsu JC, Laurent-Rolle M, Pawlak JB, Xia H, Kunte A, Hee JS, Lim J, Harris LD, Wood JM, Evans GB, Shi PY, Grove TL, Almo SC, Cresswell P. Mol Cell. 2022 May 5;82(9):1631-1642.e6. doi: 10.1016/j.molcel.2022.02.031. Epub 2022 Mar 21. PubMed |
| 1alpha,25(OH)2D3 reverses exhaustion and enhances antitumor immunity of human cytotoxic T cells. Li P, Zhu X, Cao G, Wu R, Li K, Yuan W, Chen B, Sun G, Xia X, Zhang H, Wang X, Yin Z, Lu L, Gao Y. J Immunother Cancer. 2022 Mar;10(3). pii: jitc-2021-003477. doi: 10.1136/jitc-2021-003477. PubMed |
| YTHDF1 upregulation mediates hypoxia-dependent breast cancer growth and metastasis through regulating PKM2 to affect glycolysis. Yao X, Li W, Li L, Li M, Zhao Y, Fang, Zeng X, Luo Z. Cell Death Dis. 2022 Mar 23;13(3):258. doi: 10.1038/s41419-022-04711-1. PubMed |
| The mTOR chromatin-bound interactome in prostate cancer. Dufour CR, Scholtes C, Yan M, Chen Y, Han L, Li T, Xia H, Deng Q, Vernier M, Giguere V. Cell Rep. 2022 Mar 22;38(12):110534. doi: 10.1016/j.celrep.2022.110534. PubMed |
| The RNA helicase DHX15 is a critical regulator of natural killer-cell homeostasis and functions. Wang G, Xiao X, Wang Y, Chu X, Dou Y, Minze LJ, Ghobrial RM, Zhang Z, Li XC. Cell Mol Immunol. 2022 Jun;19(6):687-701. doi: 10.1038/s41423-022-00852-7. Epub 2022 Mar 23. PubMed |
| Nuclear receptor activation shapes spatial genome organization essential for gene expression control: lessons learned from the vitamin D receptor. Warwick T, Schulz MH, Gilsbach R, Brandes RP, Seuter S. Nucleic Acids Res. 2022 Apr 22;50(7):3745-3763. doi: 10.1093/nar/gkac178. PubMed |
| Potential Metabolite Markers for Pancreatic Cancer Identified by Metabolomic Analysis of Induced Cancer-Associated Fibroblasts. Miyazaki Y, Mori N, Akagi Y, Oda T, Kida YS. Cancers (Basel). 2022 Mar 8;14(6). pii: cancers14061375. doi: 10.3390/cancers14061375. PubMed |
| MET Exon 14 Splice-Site Mutations Preferentially Activate KRAS Signaling to Drive Tumourigenesis. Lu D, Nagelberg A, Chow JL, Chen YT, Michalchuk Q, Somwar R, Lockwood WW. Cancers (Basel). 2022 Mar 8;14(6). pii: cancers14061378. doi: 10.3390/cancers14061378. PubMed |
| Human C1q Regulates Influenza A Virus Infection and Inflammatory Response via Its Globular Domain. Varghese PM, Kishore U, Rajkumari R. Int J Mol Sci. 2022 Mar 11;23(6). pii: ijms23063045. doi: 10.3390/ijms23063045. PubMed |
| A Comparative Transcriptomic Analysis Reveals That HSP90AB1 Is Involved in the Immune and Inflammatory Responses to Porcine Deltacoronavirus Infection. Zhao Y, Chen R, Xiao D, Zhang L, Song D, Wen Y, Wu R, Zhao Q, Du S, Wen X, Cao S, Huang X. Int J Mol Sci. 2022 Mar 18;23(6). pii: ijms23063280. doi: 10.3390/ijms23063280. PubMed |
| Integrative network analysis of early-stage lung adenocarcinoma identifies aurora kinase inhibition as interceptor of invasion and progression. Yoo S, Sinha A, Yang D, Altorki NK, Tandon R, Wang W, Chavez D, Lee E, Patel AS, Sato T, Kong R, Ding B, Schadt EE, Watanabe H, Massion PP, Borczuk AC, Zhu J, Powell CA. Nat Commun. 2022 Mar 24;13(1):1592. doi: 10.1038/s41467-022-29230-7. PubMed |
| Avian influenza viruses suppress innate immunity by inducing trans-transcriptional readthrough via SSU72. Zhao Y, Huang F, Zou Z, Bi Y, Yang Y, Zhang C, Liu Q, Shang D, Yan Y, Ju X, Mei S, Xie P, Li X, Tian M, Tan S, Lu H, Han Z, Liu K, Zhang Y, Liang J, Liang Z, Zhang Q, Chang J, Liu WJ, Feng C, Li T, Zhang MQ, Wang X, Gao GF, Liu Y, Jin N, Jiang C. Cell Mol Immunol. 2022 Jun;19(6):702-714. doi: 10.1038/s41423-022-00843-8. Epub 2022 Mar 24. PubMed |
| Orthogonally induced differentiation of stem cells for the programmatic patterning of vascularized organoids and bioprinted tissues. Skylar-Scott MA, Huang JY, Lu A, Ng AHM, Duenki T, Liu S, Nam LL, Damaraju S, Church GM, Lewis JA. Nat Biomed Eng. 2022 Apr;6(4):449-462. doi: 10.1038/s41551-022-00856-8. Epub 2022 Mar 24. PubMed |
| Study of Viral Photoinactivation by UV-C Light and Photosensitizer Using a Pseudotyped Model. Sadraeian M, Junior FFP, Miranda M, Galinskas J, Fernandes RS, da Cruz EF, Fu L, Zhang L, Diaz RS, Cabral-Miranda G, Guimaraes FEG. Pharmaceutics. 2022 Mar 21;14(3). pii: pharmaceutics14030683. doi: 10.3390/pharmaceutics14030683. PubMed |
| CRISPR activation screen identifies BCL-2 proteins and B3GNT2 as drivers of cancer resistance to T cell-mediated cytotoxicity. Joung J, Kirchgatterer PC, Singh A, Cho JH, Nety SP, Larson RC, Macrae RK, Deasy R, Tseng YY, Maus MV, Zhang F. Nat Commun. 2022 Mar 25;13(1):1606. doi: 10.1038/s41467-022-29205-8. PubMed |
| Guide RNAs containing universal bases enable Cas9/Cas12a recognition of polymorphic sequences. Krysler AR, Cromwell CR, Tu T, Jovel J, Hubbard BP. Nat Commun. 2022 Mar 25;13(1):1617. doi: 10.1038/s41467-022-29202-x. PubMed |
| PD-LI promotes rear retraction during persistent cell migration by altering integrin beta4 dynamics. Wang M, Xiong C, Mercurio AM. J Cell Biol. 2022 May 2;221(5):e202108083. doi: 10.1083/jcb.202108083. Epub 2022 Mar 28. PubMed |
| CRISPR Guide RNA Library Screens in Human Induced Pluripotent Stem Cells. Zhou Y, Fu Q, Shi H, Zhou G. Methods Mol Biol. 2022;2549:233-257. doi: 10.1007/7651_2021_455. PubMed |
| Ricolinostat enhances adavosertibinduced mitotic catastrophe in TP53mutated head and neck squamous cell carcinoma cells. Miyake K, Takano N, Kazama H, Kikuchi H, Hiramoto M, Tsukahara K, Miyazawa K. Int J Oncol. 2022 May;60(5). pii: 54. doi: 10.3892/ijo.2022.5344. Epub 2022 Mar 29. PubMed |
| FOXK2 promotes ovarian cancer stemness by regulating the unfolded protein response pathway. Zhang Y, Wang Y, Zhao G, Tanner EJ, Adli M, Matei D. J Clin Invest. 2022 May 16;132(10). pii: 151591. doi: 10.1172/JCI151591. PubMed |
| ESCRT-I fuels lysosomal degradation to restrict TFEB/TFE3 signaling via the Rag-mTORC1 pathway. Wrobel M, Cendrowski J, Szymanska E, Grebowicz-Maciukiewicz M, Budick-Harmelin N, Macias M, Szybinska A, Mazur M, Kolmus K, Goryca K, Dabrowska M, Paziewska A, Mikula M, Miaczynska M. Life Sci Alliance. 2022 Mar 30;5(7). pii: 5/7/e202101239. doi: 10.26508/lsa.202101239. Print 2022 Jul. PubMed |
| Genetic instability from a single S phase after whole-genome duplication. Gemble S, Wardenaar R, Keuper K, Srivastava N, Nano M, Mace AS, Tijhuis AE, Bernhard SV, Spierings DCJ, Simon A, Goundiam O, Hochegger H, Piel M, Foijer F, Storchova Z, Basto R. Nature. 2022 Apr;604(7904):146-151. doi: 10.1038/s41586-022-04578-4. Epub 2022 Mar 30. PubMed |
| Human distal lung maps and lineage hierarchies reveal a bipotent progenitor. Kadur Lakshminarasimha Murthy P, Sontake V, Tata A, Kobayashi Y, Macadlo L, Okuda K, Conchola AS, Nakano S, Gregory S, Miller LA, Spence JR, Engelhardt JF, Boucher RC, Rock JR, Randell SH, Tata PR. Nature. 2022 Apr;604(7904):111-119. doi: 10.1038/s41586-022-04541-3. Epub 2022 Mar 30. PubMed |
Sensitivity of VHL mutant kidney cancers to HIF2 inhibitors does not require an intact p53 pathway.
Stransky LA, Vigeant SM, Huang B, West D, Denize T, Walton E, Signoretti S, Kaelin WG Jr.
Proc Natl Acad Sci U S A. 2022 Apr 5;119(14):e2120403119. doi: 10.1073/pnas.2120403119. Epub 2022 Mar 31.
PubMed
Associated Plasmids |
| Folliculin promotes substrate-selective mTORC1 activity by activating RagC to recruit TFE3. Li K, Wada S, Gosis BS, Thorsheim C, Loose P, Arany Z. PLoS Biol. 2022 Mar 31;20(3):e3001594. doi: 10.1371/journal.pbio.3001594. eCollection 2022 Mar. PubMed |
| High-throughput identification of autoantibodies that target the human exoproteome. Wang EY, Dai Y, Rosen CE, Schmitt MM, Dong MX, Ferre EMN, Liu F, Yang Y, Gonzalez-Hernandez JA, Meffre E, Hinchcliff M, Koumpouras F, Lionakis MS, Ring AM. Cell Rep Methods. 2022 Feb 28;2(2). doi: 10.1016/j.crmeth.2022.100172. Epub 2022 Feb 17. PubMed |
| Altered propionate metabolism contributes to tumour progression and aggressiveness. Gomes AP, Ilter D, Low V, Drapela S, Schild T, Mullarky E, Han J, Elia I, Broekaert D, Rosenzweig A, Nagiec M, Nunes JB, Schaffer BE, Mutvei AP, Asara JM, Cantley LC, Fendt SM, Blenis J. Nat Metab. 2022 Apr;4(4):435-443. doi: 10.1038/s42255-022-00553-5. Epub 2022 Mar 31. PubMed |
| PRMT5 Interacting Partners and Substrates in Oligodendrocyte Lineage Cells. Dansu DK, Liang J, Selcen I, Zheng H, Moore DF, Casaccia P. Front Cell Neurosci. 2022 Mar 17;16:820226. doi: 10.3389/fncel.2022.820226. eCollection 2022. PubMed |
| Loss of Rnf31 and Vps4b sensitizes pancreatic cancer to T cell-mediated killing. Frey N, Tortola L, Egli D, Janjuha S, Rothgangl T, Marquart KF, Ampenberger F, Kopf M, Schwank G. Nat Commun. 2022 Apr 4;13(1):1804. doi: 10.1038/s41467-022-29412-3. PubMed |
| A functional SNP rs895819 on pre-miR-27a is associated with bipolar disorder by targeting NCAM1. Yang Y, Lu W, Ning M, Zhou X, Wan X, Mi Q, Yang X, Zhang D, Zhang Y, Jiang B, He L, Liu J, Zou Y. Commun Biol. 2022 Apr 4;5(1):309. doi: 10.1038/s42003-022-03263-6. PubMed |
| Dual-gRNA approach with limited off-target effect corrects C9ORF72 repeat expansion in vivo. Piao X, Meng D, Zhang X, Song Q, Lv H, Jia Y. Sci Rep. 2022 Apr 5;12(1):5672. doi: 10.1038/s41598-022-07746-8. PubMed |
| SARS-CoV-2 antigen exposure history shapes phenotypes and specificity of memory CD8(+) T cells. Minervina AA, Pogorelyy MV, Kirk AM, Crawford JC, Allen EK, Chou CH, Mettelman RC, Allison KJ, Lin CY, Brice DC, Zhu X, Vegesana K, Wu G, Trivedi S, Kottapalli P, Darnell D, McNeely S, Olsen SR, Schultz-Cherry S, Estepp JH, McGargill MA, Wolf J, Thomas PG. Nat Immunol. 2022 May;23(5):781-790. doi: 10.1038/s41590-022-01184-4. Epub 2022 Apr 5. PubMed |
| Enhancement of prime editing via xrRNA motif-joined pegRNA. Zhang G, Liu Y, Huang S, Qu S, Cheng D, Yao Y, Ji Q, Wang X, Huang X, Liu J. Nat Commun. 2022 Apr 6;13(1):1856. doi: 10.1038/s41467-022-29507-x. PubMed |
| STAG2 regulates interferon signaling in melanoma via enhancer loop reprogramming. Chu Z, Gu L, Hu Y, Zhang X, Li M, Chen J, Teng D, Huang M, Shen CH, Cai L, Yoshida T, Qi Y, Niu Z, Feng A, Geng S, Frederick DT, Specht E, Piris A, Sullivan RJ, Flaherty KT, Boland GM, Georgopoulos K, Liu D, Shi Y, Zheng B. Nat Commun. 2022 Apr 6;13(1):1859. doi: 10.1038/s41467-022-29541-9. PubMed |
| Lupus enhancer risk variant causes dysregulation of IRF8 through cooperative lncRNA and DNA methylation machinery. Zhou T, Zhu X, Ye Z, Wang YF, Yao C, Xu N, Zhou M, Ma J, Qin Y, Shen Y, Tang Y, Yin Z, Xu H, Zhang Y, Zang X, Ding H, Yang W, Guo Y, Harley JB, Namjou B, Kaufman KM, Kottyan LC, Weirauch MT, Hou G, Shen N. Nat Commun. 2022 Apr 6;13(1):1855. doi: 10.1038/s41467-022-29514-y. PubMed |
| Ca(2+)-activated sphingomyelin scrambling and turnover mediate ESCRT-independent lysosomal repair. Niekamp P, Scharte F, Sokoya T, Vittadello L, Kim Y, Deng Y, Sudhoff E, Hilderink A, Imlau M, Clarke CJ, Hensel M, Burd CG, Holthuis JCM. Nat Commun. 2022 Apr 6;13(1):1875. doi: 10.1038/s41467-022-29481-4. PubMed |
| Mismatch repair proteins play a role in ATR activation upon temozolomide treatment in MGMT-methylated glioblastoma. Ganesa S, Sule A, Sundaram RK, Bindra RS. Sci Rep. 2022 Apr 6;12(1):5827. doi: 10.1038/s41598-022-09614-x. PubMed |
| DAPLE orchestrates apical actomyosin assembly from junctional polarity complexes. Marivin A, Ho RX, Garcia-Marcos M. J Cell Biol. 2022 May 2;221(5):e202111002. doi: 10.1083/jcb.202111002. Epub 2022 Apr 7. PubMed |
| Multi-omic rejuvenation of human cells by maturation phase transient reprogramming. Gill D, Parry A, Santos F, Okkenhaug H, Todd CD, Hernando-Herraez I, Stubbs TM, Milagre I, Reik W. Elife. 2022 Apr 8;11:e71624. doi: 10.7554/eLife.71624. PubMed |
| Development of optimized drug-like small molecule inhibitors of the SARS-CoV-2 3CL protease for treatment of COVID-19. Liu H, Iketani S, Zask A, Khanizeman N, Bednarova E, Forouhar F, Fowler B, Hong SJ, Mohri H, Nair MS, Huang Y, Tay NES, Lee S, Karan C, Resnick SJ, Quinn C, Li W, Shion H, Xia X, Daniels JD, Bartolo-Cruz M, Farina M, Rajbhandari P, Jurtschenko C, Lauber MA, McDonald T, Stokes ME, Hurst BL, Rovis T, Chavez A, Ho DD, Stockwell BR. Nat Commun. 2022 Apr 7;13(1):1891. doi: 10.1038/s41467-022-29413-2. PubMed |
| Modification of BRCA1-associated breast cancer risk by HMMR overexpression. Mateo F, He Z, Mei L, de Garibay GR, Herranz C, Garcia N, Lorentzian A, Baiges A, Blommaert E, Gomez A, Mirallas O, Garrido-Utrilla A, Palomero L, Espin R, Extremera AI, Soler-Monso MT, Petit A, Li R, Brunet J, Chen K, Tan S, Eaves CJ, McCloskey C, Hakem R, Khokha R, Lange PF, Lazaro C, Maxwell CA, Pujana MA. Nat Commun. 2022 Apr 7;13(1):1895. doi: 10.1038/s41467-022-29335-z. PubMed |
| Ubiquitin ligase STUB1 destabilizes IFNgamma-receptor complex to suppress tumor IFNgamma signaling. Apriamashvili G, Vredevoogd DW, Krijgsman O, Bleijerveld OB, Ligtenberg MA, de Bruijn B, Boshuizen J, Traets JJH, D'Empaire Altimari D, van Vliet A, Lin CP, Visser NL, Londino JD, Sanchez-Hodge R, Oswalt LE, Altinok S, Schisler JC, Altelaar M, Peeper DS. Nat Commun. 2022 Apr 8;13(1):1923. doi: 10.1038/s41467-022-29442-x. PubMed |
| Phenotypic and molecular states of IDH1 mutation-induced CD24-positive glioma stem-like cells. Haddock S, Alban TJ, Turcan S, Husic H, Rosiek E, Ma X, Wang Y, Bale T, Desrichard A, Makarov V, Monette S, Wu W, Gardner R, Manova K, Boire A, Chan TA. Neoplasia. 2022 Jun;28:100790. doi: 10.1016/j.neo.2022.100790. Epub 2022 Apr 7. PubMed |
| Swine Interferon-Inducible Transmembrane Proteins Potently Inhibit African Swine Fever Virus Replication. Cai S, Zheng Z, Cheng J, Zhong L, Shao R, Zheng F, Lai Z, Ou J, Xu L, Zhou P, Lu G, Zhang G. Front Immunol. 2022 Mar 25;13:827709. doi: 10.3389/fimmu.2022.827709. eCollection 2022. PubMed |
| Anti-Fungal Drug Anidulafungin Inhibits SARS-CoV-2 Spike-Induced Syncytia Formation by Targeting ACE2-Spike Protein Interaction. Ahamad S, Ali H, Secco I, Giacca M, Gupta D. Front Genet. 2022 Mar 25;13:866474. doi: 10.3389/fgene.2022.866474. eCollection 2022. PubMed |
| PINCH-1 promotes IGF-1 receptor expression and skin cancer progression through inhibition of the GRB10-NEDD4 complex. Wang X, Wang R, Jiang K, Zhu M, Guo L, Wu C. Theranostics. 2022 Feb 28;12(6):2613-2630. doi: 10.7150/thno.70744. eCollection 2022. PubMed |
| Inhibition of MACC1-Induced Metastasis in Esophageal and Gastric Adenocarcinomas. Treese C, Werchan J, von Winterfeld M, Berg E, Hummel M, Timm L, Rau B, Daberkow O, Walther W, Daum S, Kobelt D, Stein U. Cancers (Basel). 2022 Mar 31;14(7):1773. doi: 10.3390/cancers14071773. PubMed |
| Enhancer RNA Transcription Is Essential for a Novel CSF1 Enhancer in Triple-Negative Breast Cancer. Lewis MW, Wisniewska K, King CM, Li S, Coffey A, Kelly MR, Regner MJ, Franco HL. Cancers (Basel). 2022 Apr 6;14(7). pii: cancers14071852. doi: 10.3390/cancers14071852. PubMed |
| Baicalein Activates Parkin-Dependent Mitophagy through NDP52 and OPTN. Ke PY, Chang CW, Hsiao YC. Cells. 2022 Mar 28;11(7). pii: cells11071132. doi: 10.3390/cells11071132. PubMed |
| NAMPT-dependent NAD(+) salvage is crucial for the decision between apoptotic and necrotic cell death under oxidative stress. Nishida T, Naguro I, Ichijo H. Cell Death Discov. 2022 Apr 11;8(1):195. doi: 10.1038/s41420-022-01007-3. PubMed |
| Genome-wide CRISPR screen identifies PRC2 and KMT2D-COMPASS as regulators of distinct EMT trajectories that contribute differentially to metastasis. Zhang Y, Donaher JL, Das S, Li X, Reinhardt F, Krall JA, Lambert AW, Thiru P, Keys HR, Khan M, Hofree M, Wilson MM, Yedier-Bayram O, Lack NA, Onder TT, Bagci-Onder T, Tyler M, Tirosh I, Regev A, Lees JA, Weinberg RA. Nat Cell Biol. 2022 Apr;24(4):554-564. doi: 10.1038/s41556-022-00877-0. Epub 2022 Apr 11. PubMed |
| Circadian Regulator CLOCK Drives Immunosuppression in Glioblastoma. Xuan W, Hsu WH, Khan F, Dunterman M, Pang L, Wainwright DA, Ahmed AU, Heimberger AB, Lesniak MS, Chen P. Cancer Immunol Res. 2022 Jun 3;10(6):770-784. doi: 10.1158/2326-6066.CIR-21-0559. PubMed |
| Imprinted SARS-CoV-2-specific memory lymphocytes define hybrid immunity. Rodda LB, Morawski PA, Pruner KB, Fahning ML, Howard CA, Franko N, Logue J, Eggenberger J, Stokes C, Golez I, Hale M, Gale M Jr, Chu HY, Campbell DJ, Pepper M. Cell. 2022 Apr 28;185(9):1588-1601.e14. doi: 10.1016/j.cell.2022.03.018. Epub 2022 Mar 17. PubMed |
| Sinomenine hydrochloride suppresses the stemness of breast cancer stem cells by inhibiting Wnt signaling pathway through down-regulation of WNT10B. Li X, Chen W, Huang L, Zhu M, Zhang H, Si Y, Li H, Luo Q, Yu B. Pharmacol Res. 2022 May;179:106222. doi: 10.1016/j.phrs.2022.106222. Epub 2022 Apr 9. PubMed |
| Stem cell conversion to the cardiac lineage requires nucleotide signalling from apoptosing cells. Fort L, Gama V, Macara IG. Nat Cell Biol. 2022 Apr;24(4):434-447. doi: 10.1038/s41556-022-00888-x. Epub 2022 Apr 12. PubMed |
| Mitolysosome exocytosis, a mitophagy-independent mitochondrial quality control in flunarizine-induced parkinsonism-like symptoms. Bao F, Zhou L, Zhou R, Huang Q, Chen J, Zeng S, Wu Y, Yang L, Qian S, Wang M, He X, Liang S, Qi J, Xiang G, Long Q, Guo J, Ying Z, Zhou Y, Zhao Q, Zhang J, Zhang D, Sun W, Gao M, Wu H, Zhao Y, Nie J, Li M, Chen Q, Chen J, Zhang X, Pan G, Zhang H, Li M, Tian M, Liu X. Sci Adv. 2022 Apr 15;8(15):eabk2376. doi: 10.1126/sciadv.abk2376. Epub 2022 Apr 13. PubMed |
| The nuclear receptor ERR cooperates with the cardiogenic factor GATA4 to orchestrate cardiomyocyte maturation. Sakamoto T, Batmanov K, Wan S, Guo Y, Lai L, Vega RB, Kelly DP. Nat Commun. 2022 Apr 13;13(1):1991. doi: 10.1038/s41467-022-29733-3. PubMed |
| Aberrant R-loop-induced replication stress in MED12-mutant uterine fibroids. Muralimanoharan S, Shamby R, Stansbury N, Schenken R, de la Pena Avalos B, Javanmardi S, Dray E, Sung P, Boyer TG. Sci Rep. 2022 Apr 13;12(1):6169. doi: 10.1038/s41598-022-10188-x. PubMed |
A Single Transcript Knockdown-Replacement Strategy Employing 5' UTR Secondary Structures to Precisely Titrate Rescue Protein Translation.
Millette MM, Holland ED, Tenpas TJ, Dent EW.
Front Genome Ed. 2022 Mar 28;4:803375. doi: 10.3389/fgeed.2022.803375. eCollection 2022.
PubMed
Associated Plasmids |
| SLC35B2 Acts in a Dual Role in the Host Sulfation Required for EV71 Infection. Guo D, Yu X, Wang D, Li Z, Zhou Y, Xu G, Yuan B, Qin Y, Chen M. J Virol. 2022 May 11;96(9):e0204221. doi: 10.1128/jvi.02042-21. Epub 2022 Apr 14. PubMed |
Inducible CRISPR activation screen for interferon-stimulated genes identifies OAS1 as a SARS-CoV-2 restriction factor.
Danziger O, Patel RS, DeGrace EJ, Rosen MR, Rosenberg BR.
PLoS Pathog. 2022 Apr 14;18(4):e1010464. doi: 10.1371/journal.ppat.1010464. eCollection 2022 Apr.
PubMed
Associated Plasmids |
| The nuclear lamina binds the EBV genome during latency and regulates viral gene expression. Caruso LB, Guo R, Keith K, Madzo J, Maestri D, Boyle S, Wasserman J, Kossenkov A, Gewurz BE, Tempera I. PLoS Pathog. 2022 Apr 14;18(4):e1010400. doi: 10.1371/journal.ppat.1010400. eCollection 2022 Apr. PubMed |
| Genome-Wide Knockout Screen Identifies EGLN3 Involving in Ammonia Neurotoxicity. Li J, Chen C, Li C, Hu Z, Tan J, Zeng L. Front Cell Dev Biol. 2022 Mar 29;10:820692. doi: 10.3389/fcell.2022.820692. eCollection 2022. PubMed |
| Ovarian cancer immunogenicity is governed by a narrow subset of progenitor tissue-resident memory T cells. Anadon CM, Yu X, Hanggi K, Biswas S, Chaurio RA, Martin A, Payne KK, Mandal G, Innamarato P, Harro CM, Mine JA, Sprenger KB, Cortina C, Powers JJ, Costich TL, Perez BA, Gatenbee CD, Prabhakaran S, Marchion D, Heemskerk MHM, Curiel TJ, Anderson AR, Wenham RM, Rodriguez PC, Conejo-Garcia JR. Cancer Cell. 2022 May 9;40(5):545-557.e13. doi: 10.1016/j.ccell.2022.03.008. Epub 2022 Apr 14. PubMed |
| MAFB promotes the malignant phenotypes by IGFBP6 in esophageal squamous cell carcinomas. Zhang S, Gong T, Nan Y, Feng R, Liu Z, Chen H. Exp Cell Res. 2022 Jul 1;416(1):113158. doi: 10.1016/j.yexcr.2022.113158. Epub 2022 Apr 14. PubMed |
| m6A and YTHDF proteins contribute to the localization of select neuronal mRNAs. Flamand MN, Meyer KD. Nucleic Acids Res. 2022 May 6;50(8):4464-4483. doi: 10.1093/nar/gkac251. PubMed |
| DENR controls JAK2 translation to induce PD-L1 expression for tumor immune evasion. Chen B, Hu J, Hu X, Chen H, Bao R, Zhou Y, Ye Y, Zhan M, Cai W, Li H, Li HB. Nat Commun. 2022 Apr 19;13(1):2059. doi: 10.1038/s41467-022-29754-y. PubMed |
| USP25 promotes pathological HIF-1-driven metabolic reprogramming and is a potential therapeutic target in pancreatic cancer. Nelson JK, Thin MZ, Evan T, Howell S, Wu M, Almeida B, Legrave N, Koenis DS, Koifman G, Sugimoto Y, Llorian Sopena M, MacRae J, Nye E, Howell M, Snijders AP, Prachalias A, Zen Y, Sarker D, Behrens A. Nat Commun. 2022 Apr 19;13(1):2070. doi: 10.1038/s41467-022-29684-9. PubMed |
| Inhibition of the succinyl dehydrogenase complex in acute myeloid leukemia leads to a lactate-fuelled respiratory metabolic vulnerability. Erdem A, Marin S, Pereira-Martins DA, Geugien M, Cunningham A, Pruis MG, Weinhauser I, Gerding A, Bakker BM, Wierenga ATJ, Rego EM, Huls G, Cascante M, Schuringa JJ. Nat Commun. 2022 Apr 19;13(1):2013. doi: 10.1038/s41467-022-29639-0. PubMed |
| A loss-of-adhesion CRISPR-Cas9 screening platform to identify cell adhesion-regulatory proteins and signaling pathways. de Rooij MFM, Thus YJ, Swier N, Beijersbergen RL, Pals ST, Spaargaren M. Nat Commun. 2022 Apr 19;13(1):2136. doi: 10.1038/s41467-022-29835-y. PubMed |
| Mitotic Spindle Positioning (MISP) is an actin bundler that selectively stabilizes the rootlets of epithelial microvilli. Morales EA, Arnaiz C, Krystofiak ES, Zanic M, Tyska MJ. Cell Rep. 2022 Apr 19;39(3):110692. doi: 10.1016/j.celrep.2022.110692. PubMed |
| The caspase-2 substrate p54nrb exhibits a multifaceted role in tumor cell death susceptibility via gene regulatory functions. Eichler M, Distler U, Nasrullah U, Krishnan A, Kaulich M, Husnjak K, Eberhardt W, Rajalingam K, Tenzer S, Pfeilschifter J, Imre G. Cell Death Dis. 2022 Apr 20;13(4):386. doi: 10.1038/s41419-022-04829-2. PubMed |
| TRMT6/61A-dependent base methylation of tRNA-derived fragments regulates gene-silencing activity and the unfolded protein response in bladder cancer. Su Z, Monshaugen I, Wilson B, Wang F, Klungland A, Ougland R, Dutta A. Nat Commun. 2022 Apr 20;13(1):2165. doi: 10.1038/s41467-022-29790-8. PubMed |
| BRAF Inhibitor Resistance Confers Increased Sensitivity to Mitotic Inhibitors. Misek SA, Foda BM, Dexheimer TS, Akram M, Conrad SE, Schmidt JC, Neubig RR, Gallo KA. Front Oncol. 2022 Apr 4;12:766794. doi: 10.3389/fonc.2022.766794. eCollection 2022. PubMed |
| PRC1 and RACGAP1 are Diagnostic Biomarkers of Early HCC and PRC1 Drives Self-Renewal of Liver Cancer Stem Cells. Liao S, Wang K, Zhang L, Shi G, Wang Z, Chen Z, Zhu P, He Q. Front Cell Dev Biol. 2022 Apr 4;10:864051. doi: 10.3389/fcell.2022.864051. eCollection 2022. PubMed |
| Secretory autophagy maintains proteostasis upon lysosome inhibition. Solvik TA, Nguyen TA, Tony Lin YH, Marsh T, Huang EJ, Wiita AP, Debnath J, Leidal AM. J Cell Biol. 2022 Jun 6;221(6). pii: 213172. doi: 10.1083/jcb.202110151. Epub 2022 Apr 21. PubMed |
| Mitochondrial dynamics regulate genome stability via control of caspase-dependent DNA damage. Cao K, Riley JS, Heilig R, Montes-Gomez AE, Vringer E, Berthenet K, Cloix C, Elmasry Y, Spiller DG, Ichim G, Campbell KJ, Gilmore AP, Tait SWG. Dev Cell. 2022 May 23;57(10):1211-1225.e6. doi: 10.1016/j.devcel.2022.03.019. Epub 2022 Apr 20. PubMed |
| Multilayered omics reveal sex- and depot-dependent adipose progenitor cell heterogeneity. Shan B, Barker CS, Shao M, Zhang Q, Gupta RK, Wu Y. Cell Metab. 2022 May 3;34(5):783-799.e7. doi: 10.1016/j.cmet.2022.03.012. Epub 2022 Apr 20. PubMed |
| Cellular abundance of sodium phosphate cotransporter SLC20A1/PiT1 and phosphate uptake are controlled post-transcriptionally by ESCRT. Zechner C, Henne WM, Sathe AA, Xing C, Hernandez G, Sun S, Cheong MC. J Biol Chem. 2022 Jun;298(6):101945. doi: 10.1016/j.jbc.2022.101945. Epub 2022 Apr 18. PubMed |
| PD-L1 signaling selectively regulates T cell lymphatic transendothelial migration. Piao W, Li L, Saxena V, Iyyathurai J, Lakhan R, Zhang Y, Lape IT, Paluskievicz C, Hippen KL, Lee Y, Silverman E, Shirkey MW, Riella LV, Blazar BR, Bromberg JS. Nat Commun. 2022 Apr 21;13(1):2176. doi: 10.1038/s41467-022-29930-0. PubMed |
| HMCES protects immunoglobulin genes specifically from deletions during somatic hypermutation. Wu L, Shukla V, Yadavalli AD, Dinesh RK, Xu D, Rao A, Schatz DG. Genes Dev. 2022 Apr 1;36(7-8):433-450. doi: 10.1101/gad.349438.122. Epub 2022 Apr 21. PubMed |
| Active endogenous retroviral elements in human pluripotent stem cells play a role in regulating host gene expression. Zhang T, Zheng R, Li M, Yan C, Lan X, Tong B, Lu P, Jiang W. Nucleic Acids Res. 2022 May 20;50(9):4959-4973. doi: 10.1093/nar/gkac265. PubMed |
| SOD1 mediates lysosome-to-mitochondria communication and its dysregulation by amyloid-beta oligomers. Norambuena A, Sun X, Wallrabe H, Cao R, Sun N, Pardo E, Shivange N, Wang DB, Post LA, Ferris HA, Hu S, Periasamy A, Bloom GS. Neurobiol Dis. 2022 Jul;169:105737. doi: 10.1016/j.nbd.2022.105737. Epub 2022 Apr 20. PubMed |
| Histone Demethylase KDM5C Drives Prostate Cancer Progression by Promoting EMT. Lemster AL, Sievers E, Pasternack H, Lazar-Karsten P, Klumper N, Sailer V, Offermann A, Bragelmann J, Perner S, Kirfel J. Cancers (Basel). 2022 Apr 8;14(8). pii: cancers14081894. doi: 10.3390/cancers14081894. PubMed |
| A protocol for CRISPR-mediated activation and repression of human endogenous retroviruses in human pluripotent stem cells. Nair VP, Mayer J, Vincendeau M. STAR Protoc. 2022 Apr 12;3(2):101281. doi: 10.1016/j.xpro.2022.101281. eCollection 2022 Jun 17. PubMed |
| An engineered ACE2 decoy neutralizes the SARS-CoV-2 Omicron variant and confers protection against infection in vivo. Ikemura N, Taminishi S, Inaba T, Arimori T, Motooka D, Katoh K, Kirita Y, Higuchi Y, Li S, Suzuki T, Itoh Y, Ozaki Y, Nakamura S, Matoba S, Standley DM, Okamoto T, Takagi J, Hoshino A. Sci Transl Med. 2022 Jun 22;14(650):eabn7737. doi: 10.1126/scitranslmed.abn7737. Epub 2022 Jun 22. PubMed |
| Reduced IRF4 expression promotes lytic phenotype in Type 2 EBV-infected B cells. Bristol JA, Brand J, Ohashi M, Eichelberg MR, Casco A, Nelson SE, Hayes M, Romero-Masters JC, Baiu DC, Gumperz JE, Johannsen EC, Dinh HQ, Kenney SC. PLoS Pathog. 2022 Apr 26;18(4):e1010453. doi: 10.1371/journal.ppat.1010453. eCollection 2022 Apr. PubMed |
| Oncohistone Mutations Occur at Functional Sites of Regulatory ADP-Ribosylation. Huang D, Camacho CV, Martire S, Nagari A, Setlem R, Gong X, Edwards AD, Chiu SP, Banaszynski LA, Kraus WL. Cancer Res. 2022 Jul 5;82(13):2361-2377. doi: 10.1158/0008-5472.CAN-22-0742. PubMed |
| lncRNA-H19 in Fibroblasts Promotes Wound Healing in Diabetes. Yu P, Guo J, Li J, Shi X, Xu N, Jiang Y, Chen W, Hu Q. Diabetes. 2022 Jul 1;71(7):1562-1578. doi: 10.2337/db21-0724. PubMed |
| Leukemia/lymphoma-related factor (LRF) or osteoclast zinc finger protein (OCZF) overexpression promotes osteoclast survival by increasing Bcl-xl mRNA: A novel regulatory mechanism mediated by the RNA binding protein SAM68. Xu X, Shobuike T, Shiraki M, Kamohara A, Hirata H, Murayama M, Mawatari D, Ueno M, Morimoto T, Kukita T, Mawatari M, Kukita A. Lab Invest. 2022 Sep;102(9):1000-1010. doi: 10.1038/s41374-022-00792-w. Epub 2022 Apr 26. PubMed |
| Development and characterization of new tools for detecting poly(ADP-ribose) in vitro and in vivo. Challa S, Ryu KW, Whitaker AL, Abshier JC, Camacho CV, Kraus WL. Elife. 2022 Apr 27;11. pii: 72464. doi: 10.7554/eLife.72464. PubMed |
| Genomewide CRISPR knockout screen identified PLAC8 as an essential factor for SADS-CoVs infection. Tse LV, Meganck RM, Araba KC, Yount BL, Shaffer KM, Hou YJ, Munt JE, Adams LE, Wykoff JA, Morowitz JM, Dong S, Magness ST, Marzluff WF, Gonzalez LM, Ehre C, Baric RS. Proc Natl Acad Sci U S A. 2022 May 3;119(18):e2118126119. doi: 10.1073/pnas.2118126119. Epub 2022 Apr 27. PubMed |
| ASCL1 activates neuronal stem cell-like lineage programming through remodeling of the chromatin landscape in prostate cancer. Nouruzi S, Ganguli D, Tabrizian N, Kobelev M, Sivak O, Namekawa T, Thaper D, Baca SC, Freedman ML, Aguda A, Davies A, Zoubeidi A. Nat Commun. 2022 Apr 27;13(1):2282. doi: 10.1038/s41467-022-29963-5. PubMed |
| A critical ETV4/Twist1/Vimentin axis in Ha-RAS-induced aggressive breast cancer. Liu W, Gajendran B, Sample KM, Wang C, Hu A, Chen B, Li Y, Zacksenhaus E, Ben-David Y. Cancer Gene Ther. 2022 Apr 27. pii: 10.1038/s41417-022-00471-4. doi: 10.1038/s41417-022-00471-4. PubMed |
| MYCN mediates cysteine addiction and sensitizes neuroblastoma to ferroptosis. Alborzinia H, Florez AF, Kreth S, Bruckner LM, Yildiz U, Gartlgruber M, Odoni DI, Poschet G, Garbowicz K, Shao C, Klein C, Meier J, Zeisberger P, Nadler-Holly M, Ziehm M, Paul F, Burhenne J, Bell E, Shaikhkarami M, Wurth R, Stainczyk SA, Wecht EM, Kreth J, Buttner M, Ishaque N, Schlesner M, Nicke B, Stresemann C, Llamazares-Prada M, Reiling JH, Fischer M, Amit I, Selbach M, Herrmann C, Wolfl S, Henrich KO, Hofer T, Trumpp A, Westermann F. Nat Cancer. 2022 Apr;3(4):471-485. doi: 10.1038/s43018-022-00355-4. Epub 2022 Apr 28. PubMed |
Endomembranes promote chromosome missegregation by ensheathing misaligned chromosomes.
Ferrandiz N, Downie L, Starling GP, Royle SJ.
J Cell Biol. 2022 Jun 6;221(6). pii: 213189. doi: 10.1083/jcb.202203021. Epub 2022 Apr 29.
PubMed
Associated Plasmids |
| Endogenous pannexin1 channels form functional intercellular cell-cell channels with characteristic voltage-dependent properties. Palacios-Prado N, Soto PA, Lopez X, Choi EJ, Marquez-Miranda V, Rojas M, Duarte Y, Lee J, Gonzalez-Nilo FD, Saez JC. Proc Natl Acad Sci U S A. 2022 May 3;119(18):e2202104119. doi: 10.1073/pnas.2202104119. Epub 2022 Apr 29. PubMed |
| Retinol Binding Protein 7 Promotes Adipogenesis in vitro and Regulates Expression of Genes Involved in Retinol Metabolism. Kim DH, Ahn J, Suh Y, Ziouzenkova O, Lee JW, Lee K. Front Cell Dev Biol. 2022 Apr 14;10:876031. doi: 10.3389/fcell.2022.876031. eCollection 2022. PubMed |
| Protein Tyrosine Phosphatase Receptor Type D Regulates Neuropathic Pain After Nerve Injury via the STING-IFN-I Pathway. Sun C, Wu G, Zhang Z, Cao R, Cui S. Front Mol Neurosci. 2022 Apr 14;15:859166. doi: 10.3389/fnmol.2022.859166. eCollection 2022. PubMed |
| In vitro and in vivo assay of the ER lipid scramblase TMEM41B. Wu L, Liu L, Xu B, Huang D, Chen XW. STAR Protoc. 2022 Apr 19;3(2):101333. doi: 10.1016/j.xpro.2022.101333. eCollection 2022 Jun 17. PubMed |
| Mechanism of Erastin-Induced Ferroptosis in MDA-MB-231 Human Breast Cancer Cells: Evidence for a Critical Role of Protein Disulfide Isomerase. Wang H, Wang P, Zhu BT. Mol Cell Biol. 2022 Jun 16;42(6):e0052221. doi: 10.1128/mcb.00522-21. Epub 2022 May 2. PubMed |
| MOZ and Menin-MLL Complexes Are Complementary Regulators of Chromatin Association and Transcriptional Output in Gastrointestinal Stromal Tumor. Hemming ML, Benson MR, Loycano MA, Anderson JA, Andersen JL, Taddei ML, Krivtsov AV, Aubrey BJ, Cutler JA, Hatton C, Sicinska E, Armstrong SA. Cancer Discov. 2022 Jul 6;12(7):1804-1823. doi: 10.1158/2159-8290.CD-21-0646. PubMed |
| Transcription Factor 4 loss-of-function is associated with deficits in progenitor proliferation and cortical neuron content. Papes F, Camargo AP, de Souza JS, Carvalho VMA, Szeto RA, LaMontagne E, Teixeira JR, Avansini SH, Sanchez-Sanchez SM, Nakahara TS, Santo CN, Wu W, Yao H, Araujo BMP, Velho PENF, Haddad GG, Muotri AR. Nat Commun. 2022 May 2;13(1):2387. doi: 10.1038/s41467-022-29942-w. PubMed |
| A T cell resilience model associated with response to immunotherapy in multiple tumor types. Zhang Y, Vu T, Palmer DC, Kishton RJ, Gong L, Huang J, Nguyen T, Chen Z, Smith C, Livak F, Paul R, Day CP, Wu C, Merlino G, Aldape K, Guan XY, Jiang P. Nat Med. 2022 Jul;28(7):1421-1431. doi: 10.1038/s41591-022-01799-y. Epub 2022 May 2. PubMed |
| Discovery and functional assessment of a novel adipocyte population driven by intracellular Wnt/beta-catenin signaling in mammals. Liu Z, Chen T, Zhang S, Yang T, Gong Y, Deng HW, Bai D, Tian W, Chen Y. Elife. 2022 May 3;11. pii: 77740. doi: 10.7554/eLife.77740. PubMed |
| Abnormal triaging of misfolded proteins by adult neuronal ceroid lipofuscinosis-associated DNAJC5/CSPalpha mutants causes lipofuscin accumulation. Lee J, Xu Y, Saidi L, Xu M, Zinsmaier K, Ye Y. Autophagy. 2022 May 4:1-20. doi: 10.1080/15548627.2022.2065618. PubMed |
| Targeted epigenomic editing ameliorates adult anxiety and excessive drinking after adolescent alcohol exposure. Bohnsack JP, Zhang H, Wandling GM, He D, Kyzar EJ, Lasek AW, Pandey SC. Sci Adv. 2022 May 6;8(18):eabn2748. doi: 10.1126/sciadv.abn2748. Epub 2022 May 4. PubMed |
| Identification of DAXX as a restriction factor of SARS-CoV-2 through a CRISPR/Cas9 screen. Mac Kain A, Maarifi G, Aicher SM, Arhel N, Baidaliuk A, Munier S, Donati F, Vallet T, Tran QD, Hardy A, Chazal M, Porrot F, OhAinle M, Carlson-Stevermer J, Oki J, Holden K, Zimmer G, Simon-Loriere E, Bruel T, Schwartz O, van der Werf S, Jouvenet N, Nisole S, Vignuzzi M, Roesch F. Nat Commun. 2022 May 4;13(1):2442. doi: 10.1038/s41467-022-30134-9. PubMed |
| Combinatorial GxGxE CRISPR screen identifies SLC25A39 in mitochondrial glutathione transport linking iron homeostasis to OXPHOS. Shi X, Reinstadler B, Shah H, To TL, Byrne K, Summer L, Calvo SE, Goldberger O, Doench JG, Mootha VK, Shen H. Nat Commun. 2022 May 5;13(1):2483. doi: 10.1038/s41467-022-30126-9. PubMed |
Comparative optimization of combinatorial CRISPR screens.
Li R, Klingbeil O, Monducci D, Young MJ, Rodriguez DJ, Bayyat Z, Dempster JM, Kesar D, Yang X, Zamanighomi M, Vakoc CR, Ito T, Sellers WR.
Nat Commun. 2022 May 5;13(1):2469. doi: 10.1038/s41467-022-30196-9.
PubMed
Associated Plasmids |
| SARS-CoV-2 Employ BSG/CD147 and ACE2 Receptors to Directly Infect Human Induced Pluripotent Stem Cell-Derived Kidney Podocytes. Kalejaiye TD, Bhattacharya R, Burt MA, Travieso T, Okafor AE, Mou X, Blasi M, Musah S. Front Cell Dev Biol. 2022 Apr 20;10:855340. doi: 10.3389/fcell.2022.855340. eCollection 2022. PubMed |
| The Chd4 subunit of the NuRD complex regulates Pdx1-controlled genes involved in beta-cell function. Davidson RK, Weaver SA, Casey N, Kanojia S, Hogarth E, Schneider Aguirre R, Sims EK, Evans-Molina C, Spaeth JM. J Mol Endocrinol. 2022 Jun 14;69(2):329-341. doi: 10.1530/JME-22-0011. PubMed |
| The AMPK-related kinase NUAK2 suppresses glutathione peroxidase 4 expression and promotes ferroptotic cell death in breast cancer cells. Singh T, Beatty A, Peterson JR. Cell Death Discov. 2022 May 6;8(1):253. doi: 10.1038/s41420-022-01044-y. PubMed |
| Lymph node colonization induces tumor-immune tolerance to promote distant metastasis. Reticker-Flynn NE, Zhang W, Belk JA, Basto PA, Escalante NK, Pilarowski GOW, Bejnood A, Martins MM, Kenkel JA, Linde IL, Bagchi S, Yuan R, Chang S, Spitzer MH, Carmi Y, Cheng J, Tolentino LL, Choi O, Wu N, Kong CS, Gentles AJ, Sunwoo JB, Satpathy AT, Plevritis SK, Engleman EG. Cell. 2022 May 26;185(11):1924-1942.e23. doi: 10.1016/j.cell.2022.04.019. Epub 2022 May 6. PubMed |
| Endothelial nitric oxide synthase (eNOS)-NO signaling axis functions to promote the growth of prostate cancer stem-like cells. Gao W, Wang Y, Yu S, Wang Z, Ma T, Chan AM, Chiu PK, Ng CF, Wu D, Chan FL. Stem Cell Res Ther. 2022 May 7;13(1):188. doi: 10.1186/s13287-022-02864-6. PubMed |
| LAG-3xPD-L1 bispecific antibody potentiates antitumor responses of T cells through dendritic cell activation. Sung E, Ko M, Won JY, Jo Y, Park E, Kim H, Choi E, Jung UJ, Jeon J, Kim Y, Ahn H, Choi DS, Choi S, Hong Y, Park H, Lee H, Son YG, Park K, Won J, Oh SJ, Lee S, Kim KP, Yoo C, Song HK, Jin HS, Jung J, Park Y. Mol Ther. 2022 Aug 3;30(8):2800-2816. doi: 10.1016/j.ymthe.2022.05.003. Epub 2022 May 6. PubMed |
| Comprehensive Target Screening and Cellular Profiling of the Cancer-Active Compound b-AP15 Indicate Abrogation of Protein Homeostasis and Organelle Dysfunction as the Primary Mechanism of Action. Gubat J, Selvaraju K, Sjostrand L, Kumar Singh D, Turkina MV, Schmierer B, Sabatier P, Zubarev RA, Linder S, D'Arcy P. Front Oncol. 2022 Apr 22;12:852980. doi: 10.3389/fonc.2022.852980. eCollection 2022. PubMed |
| Protease inhibitor Camostat Mesyalte blocks wild type SARS-CoV-2 and D614G viral entry in human engineered miniature lungs. Wu T, Rabi SA, Michaud WA, Becerra D, Gilpin SE, Mino-Kenudson M, Ott HC. Biomaterials. 2022 Jun;285:121509. doi: 10.1016/j.biomaterials.2022.121509. Epub 2022 Apr 11. PubMed |
| Genetic and compound screens uncover factors modulating cancer cell response to indisulam. Pogacar Z, Groot K, Jochems F, Dos Santos Dias M, Mulero-Sanchez A, Morris B, Roosen M, Wardak L, De Conti G, Velds A, Lieftink C, Thijssen B, Beijersbergen RL, Bernards R, Leite de Oliveira R. Life Sci Alliance. 2022 May 9;5(9):e202101348. doi: 10.26508/lsa.202101348. Print 2022 Sep. PubMed |
| Caveolin-1 temporal modulation enhances antibody drug efficacy in heterogeneous gastric cancer. Pereira PMR, Mandleywala K, Monette S, Lumish M, Tully KM, Panikar SS, Cornejo M, Mauguen A, Ragupathi A, Keltee NC, Mattar M, Janjigian YY, Lewis JS. Nat Commun. 2022 May 9;13(1):2526. doi: 10.1038/s41467-022-30142-9. PubMed |
| Ammonia stimulates SCAP/Insig dissociation and SREBP-1 activation to promote lipogenesis and tumour growth. Cheng C, Geng F, Li Z, Zhong Y, Wang H, Cheng X, Zhao Y, Mo X, Horbinski C, Duan W, Chakravarti A, Cheng X, Guo D. Nat Metab. 2022 May;4(5):575-588. doi: 10.1038/s42255-022-00568-y. Epub 2022 May 9. PubMed |
| IKAROS and MENIN coordinate therapeutically actionable leukemogenic gene expression in MLL-r acute myeloid leukemia. Aubrey BJ, Cutler JA, Bourgeois W, Donovan KA, Gu S, Hatton C, Perlee S, Perner F, Rahnamoun H, Theall ACP, Henrich JA, Zhu Q, Nowak RP, Kim YJ, Parvin S, Cremer A, Olsen SN, Eleuteri NA, Pikman Y, McGeehan GM, Stegmaier K, Letai A, Fischer ES, Liu XS, Armstrong SA. Nat Cancer. 2022 May;3(5):595-613. doi: 10.1038/s43018-022-00366-1. Epub 2022 May 9. PubMed |
| Interleukin-1 alpha and high mobility group box-1 secretion in polyinosinic:polycytidylic-induced colorectal cancer cells occur via RIPK1-dependent mechanism and participate in tumourigenesis. Cheng KJ, Mohamed EHM, Syafruddin SE, Ibrahim ZA. J Cell Commun Signal. 2022 May 9. pii: 10.1007/s12079-022-00681-3. doi: 10.1007/s12079-022-00681-3. PubMed |
| Antibodies induced by an ancestral SARS-CoV-2 strain that cross-neutralize variants from Alpha to Omicron BA.1. Windsor IW, Tong P, Lavidor O, Moghaddam AS, McKay LGA, Gautam A, Chen Y, MacDonald EA, Yoo DK, Griffths A, Wesemann DR, Harrison SC. Sci Immunol. 2022 Aug 12;7(74):eabo3425. doi: 10.1126/sciimmunol.abo3425. Epub 2022 Aug 12. PubMed |
| NSD1 mediates antagonism between SWI/SNF and polycomb complexes and is required for transcriptional activation upon EZH2 inhibition. Drosos Y, Myers JA, Xu B, Mathias KM, Beane EC, Radko-Juettner S, Mobley RJ, Larsen ME, Piccioni F, Ma X, Low J, Hansen BS, Peters ST, Bhanu NV, Dhanda SK, Chen T, Upadhyaya SA, Pruett-Miller SM, Root DE, Garcia BA, Partridge JF, Roberts CWM. Mol Cell. 2022 Jul 7;82(13):2472-2489.e8. doi: 10.1016/j.molcel.2022.04.015. Epub 2022 May 9. PubMed |
| Single-molecule tracking (SMT) and localization of SRF and MRTF transcription factors during neuronal stimulation and differentiation. Kuchler O, Gerlach J, Vomhof T, Hettich J, Steinmetz J, Gebhardt JCM, Michaelis J, Knoll B. Open Biol. 2022 May;12(5):210383. doi: 10.1098/rsob.210383. Epub 2022 May 11. PubMed |
| A genome-wide CRISPR-Cas9 knockout screen identifies essential and growth-restricting genes in human trophoblast stem cells. Dong C, Fu S, Karvas RM, Chew B, Fischer LA, Xing X, Harrison JK, Popli P, Kommagani R, Wang T, Zhang B, Theunissen TW. Nat Commun. 2022 May 10;13(1):2548. doi: 10.1038/s41467-022-30207-9. PubMed |
| Paracrine signalling between intestinal epithelial and tumour cells induces a regenerative programme. Jacquemin G, Wurmser A, Huyghe M, Sun W, Homayed Z, Merle C, Perkins M, Qasrawi F, Richon S, Dingli F, Arras G, Loew D, Vignjevic D, Pannequin J, Fre S. Elife. 2022 May 11;11. pii: 76541. doi: 10.7554/eLife.76541. PubMed |
| SETD4-mediated KU70 methylation suppresses apoptosis. Wang Y, Liu B, Lu H, Liu J, Romanienko PJ, Montelione GT, Shen Z. Cell Rep. 2022 May 10;39(6):110794. doi: 10.1016/j.celrep.2022.110794. PubMed |
| KSHV episome tethering sites on host chromosomes and regulation of latency-lytic switch by CHD4. Kumar A, Lyu Y, Yanagihashi Y, Chantarasrivong C, Majerciak V, Salemi M, Wang KH, Inagaki T, Chuang F, Davis RR, Tepper CG, Nakano K, Izumiya C, Shimoda M, Nakajima KI, Merleev A, Zheng ZM, Campbell M, Izumiya Y. Cell Rep. 2022 May 10;39(6):110788. doi: 10.1016/j.celrep.2022.110788. PubMed |
| Preclinical validation and phase I trial of 4-hydroxysalicylanilide, targeting ribonucleotide reductase mediated dNTP synthesis in multiple myeloma. Xie Y, Wang Y, Xu Z, Lu Y, Song D, Gao L, Yu D, Li B, Chen G, Zhang H, Feng Q, Zhang Y, Hu K, Huang C, Peng Y, Wu X, Mao Z, Shao J, Zhu W, Shi J. J Biomed Sci. 2022 May 12;29(1):32. doi: 10.1186/s12929-022-00813-2. PubMed |
| ALKBH5 regulates somatic cell reprogramming in a phase-specific manner. Khodeer S, Klungland A, Dahl JA. J Cell Sci. 2022 Jun 1;135(11). pii: 275396. doi: 10.1242/jcs.259824. Epub 2022 Jun 10. PubMed |
| Bioluminescent Zebrafish Transplantation Model for Drug Discovery. Hason M, Jovicic J, Vonkova I, Bojic M, Simon-Vermot T, White RM, Bartunek P. Front Pharmacol. 2022 Apr 27;13:893655. doi: 10.3389/fphar.2022.893655. eCollection 2022. PubMed |
| Epigenetic Repression of STING by MYC Promotes Immune Evasion and Resistance to Immune Checkpoint Inhibitors in Triple-Negative Breast Cancer. Lee KM, Lin CC, Servetto A, Bae J, Kandagatla V, Ye D, Kim G, Sudhan DR, Mendiratta S, Gonzalez Ericsson PI, Balko JM, Lee J, Barnes S, Malladi VS, Tabrizi S, Reddy SM, Yum S, Chang CW, Hutchinson KE, Yost SE, Yuan Y, Chen ZJ, Fu YX, Hanker AB, Arteaga CL. Cancer Immunol Res. 2022 Jul 1;10(7):829-843. doi: 10.1158/2326-6066.CIR-21-0826. PubMed |
| A diabetic milieu increases ACE2 expression and cellular susceptibility to SARS-CoV-2 infections in human kidney organoids and patient cells. Garreta E, Prado P, Stanifer ML, Monteil V, Marco A, Ullate-Agote A, Moya-Rull D, Vilas-Zornoza A, Tarantino C, Romero JP, Jonsson G, Oria R, Leopoldi A, Hagelkruys A, Gallo M, Gonzalez F, Domingo-Pedrol P, Gavalda A, Del Pozo CH, Hasan Ali O, Ventura-Aguiar P, Campistol JM, Prosper F, Mirazimi A, Boulant S, Penninger JM, Montserrat N. Cell Metab. 2022 Jun 7;34(6):857-873.e9. doi: 10.1016/j.cmet.2022.04.009. Epub 2022 May 12. PubMed |
| LINC00152 Drives a Competing Endogenous RNA Network in Human Hepatocellular Carcinoma. Pellegrino R, Castoldi M, Ticconi F, Skawran B, Budczies J, Rose F, Schwab C, Breuhahn K, Neumann UP, Gaisa NT, Loosen SH, Luedde T, Costa IG, Longerich T. Cells. 2022 May 3;11(9). pii: cells11091528. doi: 10.3390/cells11091528. PubMed |
| Inhibiting ALK2/ALK3 Signaling to Differentiate and Chemo-Sensitize Medulloblastoma. Filipponi D, Pagnuzzi-Boncompagni M, Pages G. Cancers (Basel). 2022 Apr 22;14(9). pii: cancers14092095. doi: 10.3390/cancers14092095. PubMed |
| Glycopeptide Antibiotic Teicoplanin Inhibits Cell Entry of SARS-CoV-2 by Suppressing the Proteolytic Activity of Cathepsin L. Yu F, Pan T, Huang F, Ying R, Liu J, Fan H, Zhang J, Liu W, Lin Y, Yuan Y, Yang T, Li R, Zhang X, Lv X, Chen Q, Liang A, Zou F, Liu B, Hu F, Tang X, Li L, Deng K, He X, Zhang H, Zhang Y, Ma X. Front Microbiol. 2022 Apr 28;13:884034. doi: 10.3389/fmicb.2022.884034. eCollection 2022. PubMed |
| UNC45A deficiency causes microvillus inclusion disease-like phenotype by impairing myosin VB-dependent apical trafficking. Duclaux-Loras R, Lebreton C, Berthelet J, Charbit-Henrion F, Nicolle O, Revenu de Courtils C, Waich S, Valovka T, Khiat A, Rabant M, Racine C, Guerrera IC, Baptista J, Mahe MM, Hess MW, Durel B, Lefort N, Banal C, Parisot M, Talbotec C, Lacaille F, Ecochard-Dugelay E, Demir AM, Vogel GF, Faivre L, Rodrigues A, Fowler D, Janecke AR, Muller T, Huber LA, Rodrigues-Lima F, Ruemmele FM, Uhlig HH, Del Bene F, Michaux G, Cerf-Bensussan N, Parlato M. J Clin Invest. 2022 May 16;132(10). pii: 154997. doi: 10.1172/JCI154997. PubMed |
| Time-course of host cell transcription during the HTLV-1 transcriptional burst. Kiik H, Ramanayake S, Miura M, Tanaka Y, Melamed A, Bangham CRM. PLoS Pathog. 2022 May 16;18(5):e1010387. doi: 10.1371/journal.ppat.1010387. eCollection 2022 May. PubMed |
| OCA-T1 and OCA-T2 are coactivators of POU2F3 in the tuft cell lineage. Wu XS, He XY, Ipsaro JJ, Huang YH, Preall JB, Ng D, Shue YT, Sage J, Egeblad M, Joshua-Tor L, Vakoc CR. Nature. 2022 Jul;607(7917):169-175. doi: 10.1038/s41586-022-04842-7. Epub 2022 May 16. PubMed |
| Purine nucleotide depletion prompts cell migration by stimulating the serine synthesis pathway. Soflaee MH, Kesavan R, Sahu U, Tasdogan A, Villa E, Djabari Z, Cai F, Tran DH, Vu HS, Ali ES, Rion H, O'Hara BP, Kelekar S, Hallett JH, Martin M, Mathews TP, Gao P, Asara JM, Manning BD, Ben-Sahra I, Hoxhaj G. Nat Commun. 2022 May 16;13(1):2698. doi: 10.1038/s41467-022-30362-z. PubMed |
| A novel ATG5 interaction with Ku70 potentiates DNA repair upon genotoxic stress. Demirbag-Sarikaya S, Akkoc Y, Turgut S, Erbil-Bilir S, Kocaturk NM, Dengjel J, Gozuacik D. Sci Rep. 2022 May 17;12(1):8134. doi: 10.1038/s41598-022-11704-9. PubMed |
| Lipolysis-Stimulated Lipoprotein Receptor Impairs Hepatocellular Carcinoma and Inhibits the Oncogenic Activity of YAP1 via PPPY Motif. Dong X, Zhang X, Liu P, Tian Y, Li L, Gong P. Front Oncol. 2022 May 2;12:896412. doi: 10.3389/fonc.2022.896412. eCollection 2022. PubMed |
Multiplex base- and prime-editing with drive-and-process CRISPR arrays.
Yuan Q, Gao X.
Nat Commun. 2022 May 19;13(1):2771. doi: 10.1038/s41467-022-30514-1.
PubMed
Associated Plasmids |
| SARS-CoV-2 delta variant infection in domestic dogs and cats, Thailand. Jairak W, Chamsai E, Udom K, Charoenkul K, Chaiyawong S, Techakriengkrai N, Tangwangvivat R, Suwannakarn K, Amonsin A. Sci Rep. 2022 May 19;12(1):8403. doi: 10.1038/s41598-022-12468-y. PubMed |
| Exogenous loading of extracellular vesicles, virus-like particles, and lentiviral vectors with supercharged proteins. Breyne K, Ughetto S, Rufino-Ramos D, Mahjoum S, Grandell EA, de Almeida LP, Breakefield XO. Commun Biol. 2022 May 19;5(1):485. doi: 10.1038/s42003-022-03440-7. PubMed |
| SARS-CoV-2 Permissive glioblastoma cell line for high throughput antiviral screening. Vanhulle E, Stroobants J, Provinciael B, Camps A, Noppen S, Maes P, Vermeire K. Antiviral Res. 2022 Jul;203:105342. doi: 10.1016/j.antiviral.2022.105342. Epub 2022 May 18. PubMed |
| F-box protein FBXO41 suppresses breast cancer growth by inducing autophagic cell death through facilitating proteasomal degradation of oncogene SKP2. Agrawal Y, Sharma T, Islam S, Nadkarni KS, Santra MK. Int J Biochem Cell Biol. 2022 Jun;147:106228. doi: 10.1016/j.biocel.2022.106228. Epub 2022 May 19. PubMed |
| Loss of PTEN-Induced Kinase 1 Regulates Oncogenic Ras-Driven Tumor Growth By Inhibiting Mitochondrial Fission. Zhu D, Han F, Sun L, Agnihotri SK, Hu Y, Bueler H. Front Oncol. 2022 May 5;12:893396. doi: 10.3389/fonc.2022.893396. eCollection 2022. PubMed |
| c-JUN inhibits mTORC2 and glucose uptake to promote self-renewal and obesity. Serna R, Ramrakhiani A, Hernandez JC, Chen CL, Nakagawa C, Machida T, Ray RB, Zhan X, Tahara SM, Machida K. iScience. 2022 Apr 29;25(6):104325. doi: 10.1016/j.isci.2022.104325. eCollection 2022 Jun 17. PubMed |
| Glycyrrhetinic acid restricts mitochondrial energy metabolism by targeting SHMT2. Jin X, Li L, Peng Q, Gan C, Gao L, He S, Tan S, Pu W, Liu Y, Gong Y, Yao Y, Wang G, Liu X, Gong M, Lei P, Zhang H, Qi S, Xu H, Hu H, Dong B, Peng Y, Su D, Dai L. iScience. 2022 May 4;25(5):104349. doi: 10.1016/j.isci.2022.104349. eCollection 2022 May 20. PubMed |
| TP53-inducible putative long noncoding RNAs encode functional polypeptides that suppress cell proliferation. Xu W, Liu C, Deng B, Lin P, Sun Z, Liu A, Xuan J, Li Y, Zhou K, Zhang X, Huang Q, Zhou H, He Q, Li B, Qu L, Yang J. Genome Res. 2022 Jun;32(6):1026-1041. doi: 10.1101/gr.275831.121. Epub 2022 May 24. PubMed |
| Synthetic gene circuits for preventing disruption of the circadian clock due to interleukin-1-induced inflammation. Pferdehirt L, Damato AR, Dudek M, Meng QJ, Herzog ED, Guilak F. Sci Adv. 2022 May 27;8(21):eabj8892. doi: 10.1126/sciadv.abj8892. Epub 2022 May 25. PubMed |
| Virucidal N95 Respirator Face Masks via Ultrathin Surface-Grafted Quaternary Ammonium Polymer Coatings. Sorci M, Fink TD, Sharma V, Singh S, Chen R, Arduini BL, Dovidenko K, Heldt CL, Palermo EF, Zha RH. ACS Appl Mater Interfaces. 2022 Jun 8;14(22):25135-25146. doi: 10.1021/acsami.2c04165. Epub 2022 May 25. PubMed |
| DELETE_A dual conditional CRISPR-Cas9 system to activate gene editing and reduce off-target effects in human stem cells. Park SB, Uchida T, Tilson S, Hu Z, Ma CD, Leek M, Eichner M, Hong SG, Liang TJ. Mol Ther Nucleic Acids. 2022 Apr 27;28:656-669. doi: 10.1016/j.omtn.2022.04.013. eCollection 2022 Jun 14. PubMed |
| Acquired chemoresistance drives spatial heterogeneity, chemoprotection and collective migration in pancreatic tumor spheroids. Thege FI, Cardle II, Gruber CN, Siemann MJ, Cong S, Wittmann K, Love J, Kirby BJ. PLoS One. 2022 May 26;17(5):e0267882. doi: 10.1371/journal.pone.0267882. eCollection 2022. PubMed |
| Nanchangmycin regulates FYN, PTK2, and MAPK1/3 to control the fibrotic activity of human hepatic stellate cells. Li W, Chen JY, Sun C, Sparks RP, Pantano L, Rahman RU, Moran SP, Pondick JV, Kirchner R, Wrobel D, Bieler M, Sauer A, Ho Sui SJ, Doerner JF, Rippmann JF, Mullen AC. Elife. 2022 May 26;11. pii: 74513. doi: 10.7554/eLife.74513. PubMed |
| Androgen and oestrogen receptor co-expression determines the efficacy of hormone receptor-mediated radiosensitisation in breast cancer. Michmerhuizen AR, Lerner LM, Ward C, Pesch AM, Zhang A, Schwartz R, Wilder-Romans K, Eisner JR, Rae JM, Pierce LJ, Speers CW. Br J Cancer. 2022 Sep;127(5):927-936. doi: 10.1038/s41416-022-01849-9. Epub 2022 May 26. PubMed |
Paired guide RNA CRISPR-Cas9 screening for protein-coding genes and lncRNAs involved in transdifferentiation of human B-cells to macrophages.
Arnan C, Ullrich S, Pulido-Quetglas C, Nurtdinov R, Esteban A, Blanco-Fernandez J, Aparicio-Prat E, Johnson R, Perez-Lluch S, Guigo R.
BMC Genomics. 2022 May 26;23(1):402. doi: 10.1186/s12864-022-08612-7.
PubMed
Associated Plasmids |
| Endocytic trafficking of GAS6-AXL complexes is associated with sustained AKT activation. Poswiata A, Kozik K, Miaczynska M, Zdzalik-Bielecka D. Cell Mol Life Sci. 2022 May 27;79(6):316. doi: 10.1007/s00018-022-04312-3. PubMed |
| NLRP3 licenses NLRP11 for inflammasome activation in human macrophages. Gangopadhyay A, Devi S, Tenguria S, Carriere J, Nguyen H, Jager E, Khatri H, Chu LH, Ratsimandresy RA, Dorfleutner A, Stehlik C. Nat Immunol. 2022 Jun;23(6):892-903. doi: 10.1038/s41590-022-01220-3. Epub 2022 May 27. PubMed |
| Transcription Factor NRF2 Participates in Cell Cycle Progression at the Level of G1/S and Mitotic Checkpoints. Lastra D, Escoll M, Cuadrado A. Antioxidants (Basel). 2022 May 11;11(5). pii: antiox11050946. doi: 10.3390/antiox11050946. PubMed |
| Reverting TP53 Mutation in Breast Cancer Cells: Prime Editing Workflow and Technical Considerations. Abuhamad AY, Mohamad Zamberi NN, Sheen L, Naes SM, Mohd Yusuf SNH, Ahmad Tajudin A, Mohtar MA, Amir Hamzah AS, Syafruddin SE. Cells. 2022 May 11;11(10). pii: cells11101612. doi: 10.3390/cells11101612. PubMed |
| The Deubiquitinase USP39 Promotes Esophageal Squamous Cell Carcinoma Malignancy as a Splicing Factor. Zhu X, Ma J, Lu M, Liu Z, Sun Y, Chen H. Genes (Basel). 2022 May 3;13(5). pii: genes13050819. doi: 10.3390/genes13050819. PubMed |
| Loss of SP-A in the Lung Exacerbates Pulmonary Fibrosis. Kim K, Shin D, Lee G, Bae H. Int J Mol Sci. 2022 May 10;23(10). pii: ijms23105292. doi: 10.3390/ijms23105292. PubMed |
| Regulation and Role of Neuron-Derived Hemoglobin in the Mouse Hippocampus. Lu Y, Wang J, Tang F, Pratap UP, Sareddy GR, Dhandapani KM, Capuano A, Arvanitakis Z, Vadlamudi RK, Brann DW. Int J Mol Sci. 2022 May 11;23(10). pii: ijms23105360. doi: 10.3390/ijms23105360. PubMed |
| Palmitoylethanolamide (PEA) Inhibits SARS-CoV-2 Entry by Interacting with S Protein and ACE-2 Receptor. Fonnesu R, Thunuguntla VBSC, Veeramachaneni GK, Bondili JS, La Rocca V, Filipponi C, Spezia PG, Sidoti M, Plicanti E, Quaranta P, Freer G, Pistello M, Mathai ML, Lai M. Viruses. 2022 May 17;14(5). pii: v14051080. doi: 10.3390/v14051080. PubMed |
| Inhibition of nuclear deacetylase Sirtuin-1 induces mitochondrial acetylation and calcium overload leading to cell death. Sun Y, Yang YM, Hu YY, Ouyang L, Sun ZH, Yin XF, Li N, He QY, Wang Y. Redox Biol. 2022 Jul;53:102334. doi: 10.1016/j.redox.2022.102334. Epub 2022 May 19. PubMed |
| Lnc-EST12, which is negatively regulated by mycobacterial EST12, suppresses antimycobacterial innate immunity through its interaction with FUBP3. Yao Q, Xie Y, Xu D, Qu Z, Wu J, Zhou Y, Wei Y, Xiong H, Zhang XL. Cell Mol Immunol. 2022 Aug;19(8):883-897. doi: 10.1038/s41423-022-00878-x. Epub 2022 May 30. PubMed |
| ADAP restraint of STAT1 signaling regulates macrophage phagocytosis in immune thrombocytopenia. Xiong Y, Li Y, Cui X, Zhang L, Yang X, Liu H. Cell Mol Immunol. 2022 Aug;19(8):898-912. doi: 10.1038/s41423-022-00881-2. Epub 2022 May 30. PubMed |
| Sperm-Associated Antigen 9 Promotes Influenza A Virus-Induced Cell Death via the c-Jun N-Terminal Kinase Signaling Pathway. Gui R, Zheng H, Ma L, Liu R, Lin X, Ke X, Ye C, Jian X, Chen Q. mBio. 2022 Jun 28;13(3):e0061522. doi: 10.1128/mbio.00615-22. Epub 2022 May 31. PubMed |
| Isoforms of Neuropilin-2 Denote Unique Tumor-Associated Macrophages in Breast Cancer. Dhupar R, Jones KE, Powers AA, Eisenberg SH, Ding K, Chen F, Nasarre C, Cen Z, Gong YN, LaRue AC, Yeh ES, Luketich JD, Lee AV, Oesterreich S, Lotze MT, Gemmill RM, Soloff AC. Front Immunol. 2022 Apr 27;13:830169. doi: 10.3389/fimmu.2022.830169. eCollection 2022. PubMed |
| Extracellular matrix regulates force transduction at VE-cadherin junctions. Kong X, Kapustka A, Sullivan B, Schwarz GJ, Leckband DE. Mol Biol Cell. 2022 Sep 15;33(11):ar95. doi: 10.1091/mbc.E22-03-0075. Epub 2022 Jun 2. PubMed |
| A pro-metastatic tRNA fragment drives Nucleolin oligomerization and stabilization of its bound metabolic mRNAs. Liu X, Mei W, Padmanaban V, Alwaseem H, Molina H, Passarelli MC, Tavora B, Tavazoie SF. Mol Cell. 2022 Jul 21;82(14):2604-2617.e8. doi: 10.1016/j.molcel.2022.05.008. Epub 2022 Jun 1. PubMed |
| 5'isomiR-183-5p|+2 elicits tumor suppressor activity in a negative feedback loop with E2F1. Li X, Michels BE, Tosun OE, Jung J, Kappes J, Ibing S, Nataraj NB, Sahay S, Schneider M, Worner A, Becki C, Ishaque N, Feuerbach L, Hessling B, Helm D, Will R, Yarden Y, Muller-Decker K, Wiemann S, Korner C. J Exp Clin Cancer Res. 2022 Jun 2;41(1):190. doi: 10.1186/s13046-022-02380-8. PubMed |
| SAFA facilitates chromatin opening of immune genes through interacting with anti-viral host RNAs. Cao L, Luo Y, Guo X, Liu S, Li S, Li J, Zhang Z, Zhao Y, Zhang Q, Gao F, Ji X, Gao X, Li Y, You F. PLoS Pathog. 2022 Jun 3;18(6):e1010599. doi: 10.1371/journal.ppat.1010599. eCollection 2022 Jun. PubMed |
| Histone deacetylase 3 facilitates TNFalpha-mediated NF-kappaB activation through suppressing CTSB induced RIP1 degradation and is required for host defense against bacterial infection. Yang L, Chen S, Xia J, Zhou Y, Peng L, Fan H, Han Y, Duan L, Cheng G, Yang H, Xu F. Cell Biosci. 2022 Jun 3;12(1):81. doi: 10.1186/s13578-022-00814-6. PubMed |
| Potential therapeutic targets discovery by transcriptome analysis of an in vitro human gastric signet ring carcinoma model. Yamaguchi K, Yoshihiro T, Ariyama H, Ito M, Nakano M, Semba Y, Nogami J, Tsuchihashi K, Yamauchi T, Ueno S, Isobe T, Shindo K, Moriyama T, Ohuchida K, Nakamura M, Nagao Y, Ikeda T, Hashizume M, Konomi H, Torisu T, Kitazono T, Kanayama T, Tomita H, Oda Y, Kusaba H, Maeda T, Akashi K, Baba E. Gastric Cancer. 2022 Sep;25(5):862-878. doi: 10.1007/s10120-022-01307-8. Epub 2022 Jun 4. PubMed |
| T cell stimulation remodels the latently HIV-1 infected cell population by differential activation of proviral chromatin. Lindqvist B, Jutte BB, Love L, Assi W, Roux J, Sonnerborg A, Tezil T, Verdin E, Svensson JP. PLoS Pathog. 2022 Jun 6;18(6):e1010555. doi: 10.1371/journal.ppat.1010555. eCollection 2022 Jun. PubMed |
An in-library ligation strategy and its application in CRISPR/Cas9 screening of high-order gRNA combinations.
Lu Z, Ni K, Wang Y, Zhou Y, Li Y, Yan J, Song Q, Liu M, Xu Y, Yu Z, Guo T, Ma L.
Nucleic Acids Res. 2022 Jun 24;50(11):6575-6586. doi: 10.1093/nar/gkac458.
PubMed
Associated Plasmids |
| EZH2 endorses cell plasticity to non-small cell lung cancer cells facilitating mesenchymal to epithelial transition and tumour colonization. Gallardo A, Molina A, Asenjo HG, Lopez-Onieva L, Martorell-Marugan J, Espinosa-Martinez M, Grinan-Lison C, Alvarez-Perez JC, Cara FE, Navarro-Marchal SA, Carmona-Saez P, Medina PP, Marchal JA, Granados-Principal S, Sanchez-Pozo A, Landeira D. Oncogene. 2022 Jul;41(28):3611-3624. doi: 10.1038/s41388-022-02375-x. Epub 2022 Jun 9. PubMed |
| Epoxyeicosatrienoic Acid and Prostanoid Crosstalk at the Receptor and Intracellular Signaling Levels to Maintain Vascular Tone. Malacarne PF, Bezzenberger J, Lopez M, Warwick T, Muller N, Brandes RP, Rezende F. Int J Mol Sci. 2022 May 25;23(11). pii: ijms23115939. doi: 10.3390/ijms23115939. PubMed |
| The risk variant rs11836367 contributes to breast cancer onset and metastasis by attenuating Wnt signaling via regulating NTN4 expression. Yang H, Ting X, Geng YH, Xie Y, Nierenberg JL, Huo YF, Zhou YT, Huang Y, Yu YQ, Yu XY, Li XF, Ziv E, Zhang H, Fang WG, Shen Y, Tian XX. Sci Adv. 2022 Jun 10;8(23):eabn3509. doi: 10.1126/sciadv.abn3509. Epub 2022 Jun 10. PubMed |
| Liver ductal organoids reconstruct intrahepatic biliary trees in decellularized liver grafts. Tomofuji K, Fukumitsu K, Kondo J, Horie H, Makino K, Wakama S, Ito T, Oshima Y, Ogiso S, Ishii T, Inoue M, Hatano E. Biomaterials. 2022 Jun 1;287:121614. doi: 10.1016/j.biomaterials.2022.121614. PubMed |
| Histone methyltransferase Dot1L recruits O-GlcNAc transferase to target chromatin sites to regulate histone O-GlcNAcylation. Xu B, Zhang C, Jiang A, Zhang X, Liang F, Wang X, Li D, Liu C, Liu X, Xia J, Li Y, Wang Y, Yang Z, Chen J, Zhou Y, Chen L, Sun H. J Biol Chem. 2022 Jul;298(7):102115. doi: 10.1016/j.jbc.2022.102115. Epub 2022 Jun 9. PubMed |
| Reciprocal regulation of NRF2 by autophagy and ubiquitin-proteasome modulates vascular endothelial injury induced by copper oxide nanoparticles. Li N, Du H, Mao L, Xu G, Zhang M, Fan Y, Dong X, Zheng L, Wang B, Qin X, Jiang X, Chen C, Zou Z, Zhang J. J Nanobiotechnology. 2022 Jun 11;20(1):270. doi: 10.1186/s12951-022-01486-7. PubMed |
| Defining pervasive transcription units using chromatin RNA-sequencing data. Guo Z, Liu X, Chen M. STAR Protoc. 2022 Jun 7;3(2):101442. doi: 10.1016/j.xpro.2022.101442. eCollection 2022 Jun 17. PubMed |
| Connexin 43 Hemichannels Regulate Osteoblast to Osteocyte Differentiation. Hua R, Gu S, Jiang JX. Front Cell Dev Biol. 2022 May 27;10:892229. doi: 10.3389/fcell.2022.892229. eCollection 2022. PubMed |
| Loss of YY1, a Regulator of Metabolism in Melanoma, Drives Melanoma Cell Invasiveness and Metastasis Formation. Guendisch U, Loos B, Cheng PF, Dummer R, Levesque MP, Varum S, Sommer L. Front Cell Dev Biol. 2022 May 26;10:916033. doi: 10.3389/fcell.2022.916033. eCollection 2022. PubMed |
| Antisense transcription from lentiviral gene targeting linked to an integrated stress response in colorectal cancer cells. Ha T, DiPrima M, Koparde V, Jailwala P, Ohnuki H, Feng JX, Palangat M, Larson D, Tosato G. Mol Ther Nucleic Acids. 2022 May 18;28:877-891. doi: 10.1016/j.omtn.2022.05.029. eCollection 2022 Jun 14. PubMed |
| Dynamic interaction of BRCA2 with telomeric G-quadruplexes underlies telomere replication homeostasis. Lee J, Sung K, Joo SY, Jeong JH, Kim SK, Lee H. Nat Commun. 2022 Jun 13;13(1):3396. doi: 10.1038/s41467-022-31156-z. PubMed |
| Long non-coding RNA HOTAIR regulates cytoskeleton remodeling and lipid storage capacity during adipogenesis. Potolitsyna E, Hazell Pickering S, Germier T, Collas P, Briand N. Sci Rep. 2022 Jun 16;12(1):10157. doi: 10.1038/s41598-022-14296-6. PubMed |
| BACE-1 inhibition facilitates the transition from homeostatic microglia to DAM-1. Singh N, Benoit MR, Zhou J, Das B, Davila-Velderrain J, Kellis M, Tsai LH, Hu X, Yan R. Sci Adv. 2022 Jun 17;8(24):eabo1286. doi: 10.1126/sciadv.abo1286. Epub 2022 Jun 17. PubMed |
| PBRM1 Deficiency Sensitizes Renal Cancer Cells to DNMT Inhibitor 5-Fluoro-2'-Deoxycytidine. Gu D, Dong K, Jiang A, Jiang S, Fu Z, Bao Y, Huang F, Yang C, Wang L. Front Oncol. 2022 Jun 3;12:870229. doi: 10.3389/fonc.2022.870229. eCollection 2022. PubMed |
| Tumor-derived CTF1 (cardiotrophin 1) is a critical mediator of stroma-assisted and autophagy-dependent breast cancer cell migration, invasion and metastasis. Akkoc Y, Dalci K, Karakas HE, Erbil-Bilir S, Yalav O, Sakman G, Celik F, Arikan S, Zeybek U, Ergin M, Akkiz H, Dilege E, Dengjel J, Dogan-Ekici AI, Gozuacik D. Autophagy. 2022 Jun 28:1-18. doi: 10.1080/15548627.2022.2090693. PubMed |
| A YAP/TAZ-TEAD signalling module links endothelial nutrient acquisition to angiogenic growth. Ong YT, Andrade J, Armbruster M, Shi C, Castro M, Costa ASH, Sugino T, Eelen G, Zimmermann B, Wilhelm K, Lim J, Watanabe S, Guenther S, Schneider A, Zanconato F, Kaulich M, Pan D, Braun T, Gerhardt H, Efeyan A, Carmeliet P, Piccolo S, Grosso AR, Potente M. Nat Metab. 2022 Jun;4(6):672-682. doi: 10.1038/s42255-022-00584-y. Epub 2022 Jun 20. PubMed |
| KDM5A Inhibits Antitumor Immune Responses Through Downregulation of the Antigen-Presentation Pathway in Ovarian Cancer. Liu H, Lin J, Zhou W, Moses R, Dai Z, Kossenkov AV, Drapkin R, Bitler BG, Karakashev S, Zhang R. Cancer Immunol Res. 2022 Aug 3;10(8):1028-1038. doi: 10.1158/2326-6066.CIR-22-0088. PubMed |
| IL-4 prevents adenosine-mediated immunoregulation by inhibiting CD39 expression. Fang F, Cao W, Mu Y, Okuyama H, Li L, Qiu J, Weyand CM, Goronzy JJ. JCI Insight. 2022 Jun 22;7(12):e157509. doi: 10.1172/jci.insight.157509. PubMed |
| DLGAP1-AS2-Mediated Phosphatidic Acid Synthesis Activates YAP Signaling and Confers Chemoresistance in Squamous Cell Carcinoma. Nan Y, Luo Q, Wu X, Liu S, Zhao P, Chang W, Zhou A, Liu Z. Cancer Res. 2022 Aug 16;82(16):2887-2903. doi: 10.1158/0008-5472.CAN-22-0717. PubMed |
| Targeting EP2 receptor with multifaceted mechanisms for high-risk neuroblastoma. Hou R, Yu Y, Sluter MN, Li L, Hao J, Fang J, Yang J, Jiang J. Cell Rep. 2022 Jun 21;39(12):111000. doi: 10.1016/j.celrep.2022.111000. PubMed |
| Lenalidomide bypasses CD28 co-stimulation to reinstate PD-1 immunotherapy by activating Notch signaling. Geng CL, Chen JY, Song TY, Jung JH, Long M, Song MF, Ji T, Min BS, Lee JG, Peng B, Pu YS, Fan HJ, Hao P, Zhou Q, Shin EC, Cang Y. Cell Chem Biol. 2022 Aug 18;29(8):1260-1272.e8. doi: 10.1016/j.chembiol.2022.05.012. Epub 2022 Jun 21. PubMed |
| CRISPR-mediated MECOM depletion retards tumor growth by reducing cancer stem cell properties in lung squamous cell carcinoma. Ma Y, Kang B, Li S, Xie G, Bi J, Li F, An G, Liu B, Li J, Shen Y, Xu X, Yang H, Yang Y, Gu Y, Wu N. Mol Ther. 2022 Nov 2;30(11):3341-3357. doi: 10.1016/j.ymthe.2022.06.011. Epub 2022 Jun 22. PubMed |
| Parkin, as a Regulator, Participates in Arsenic Trioxide-Triggered Mitophagy in HeLa Cells. Zhang Z, Yi J, Xie B, Chen J, Zhang X, Wang L, Wang J, Hou J, Wei H. Curr Issues Mol Biol. 2022 Jun 20;44(6):2759-2771. doi: 10.3390/cimb44060189. PubMed |
| Using CRISPR-Cas9 to Dissect Cancer Mutations in Cell Lines. Sayed S, Surun D, Mircetic J, Sidorova OA, Buchholz F. Methods Mol Biol. 2022;2508:235-260. doi: 10.1007/978-1-0716-2376-3_18. PubMed |
| Borneol Ester Derivatives as Entry Inhibitors of a Wide Spectrum of SARS-CoV-2 Viruses. Yarovaya OI, Shcherbakov DN, Borisevich SS, Sokolova AS, Gureev MA, Khamitov EM, Rudometova NB, Zybkina AV, Mordvinova ED, Zaykovskaya AV, Rogachev AD, Pyankov OV, Maksyutov RA, Salakhutdinov NF. Viruses. 2022 Jun 14;14(6). pii: v14061295. doi: 10.3390/v14061295. PubMed |
| Inhibition of Karyopherin beta1-Mediated Nuclear Import Disrupts Oncogenic Lineage-Defining Transcription Factor Activity in Small Cell Lung Cancer. Kelenis DP, Rodarte KE, Kollipara RK, Pozo K, Choudhuri SP, Spainhower KB, Wait SJ, Stastny V, Oliver TG, Johnson JE. Cancer Res. 2022 Sep 2;82(17):3058-3073. doi: 10.1158/0008-5472.CAN-21-3713. PubMed |
| Epigenomic analysis reveals a dynamic and context-specific macrophage enhancer landscape associated with innate immune activation and tolerance. Zhang P, Amarasinghe HE, Whalley JP, Tay C, Fang H, Migliorini G, Brown AC, Allcock A, Scozzafava G, Rath P, Davies B, Knight JC. Genome Biol. 2022 Jun 24;23(1):136. doi: 10.1186/s13059-022-02702-1. PubMed |
| The small GTPase RAB10 regulates endosomal recycling of the LDL receptor and transferrin receptor in hepatocytes. Khan TG, Ginsburg D, Emmer BT. J Lipid Res. 2022 Aug;63(8):100248. doi: 10.1016/j.jlr.2022.100248. Epub 2022 Jun 24. PubMed |
| P4HB UFMylation regulates mitochondrial function and oxidative stress. Zhu J, Ma X, Jing Y, Zhang G, Zhang D, Mao Z, Ma X, Liu H, Chen F. Free Radic Biol Med. 2022 Aug 1;188:277-286. doi: 10.1016/j.freeradbiomed.2022.06.237. Epub 2022 Jun 23. PubMed |
| HIF1alpha-Dependent Induction of TFRC by a Combination of Intestinal Inflammation and Systemic Iron Deficiency in Inflammatory Bowel Disease. Fagundes RR, Bourgonje AR, Hu S, Barbieri R, Jansen BH, Sinnema N, Blokzijl T, Taylor CT, Weersma RK, Faber KN, Dijkstra G. Front Physiol. 2022 Jun 8;13:889091. doi: 10.3389/fphys.2022.889091. eCollection 2022. PubMed |
| Engagement of TRAIL triggers degranulation and IFNgamma production in human natural killer cells. Hofle J, Trenkner T, Kleist N, Schwane V, Vollmers S, Barcelona B, Niehrs A, Fittje P, Huynh-Tran VH, Sauter J, Schmidt AH, Peine S, Hoelzemer A, Richert L, Altfeld M, Korner C. EMBO Rep. 2022 Aug 3;23(8):e54133. doi: 10.15252/embr.202154133. Epub 2022 Jun 27. PubMed |
| Regulatory Programs of B-cell Activation and Germinal Center Reaction Allow B-ALL Escape from CD19 CAR T-cell Therapy. Im NG, Guillaumet-Adkins A, Wal M, Rogers AJ, Frede J, Havig CC, Yang J, Anand P, Stegmann SK, Waldschmidt JM, Sotudeh N, Niu L, Voisine J, Schweiger MR, Grassberger C, Lohr JG, Knoechel B. Cancer Immunol Res. 2022 Sep 1;10(9):1055-1068. doi: 10.1158/2326-6066.CIR-21-0626. PubMed |
| SECISBP2L-Mediated Selenoprotein Synthesis Is Essential for Autonomous Regulation of Oligodendrocyte Differentiation. Dai ZM, Guo W, Yu D, Zhu XJ, Sun S, Huang H, Jiang M, Xie B, Zhang Z, Qiu M. J Neurosci. 2022 Jul 27;42(30):5860-5869. doi: 10.1523/JNEUROSCI.2141-21.2022. Epub 2022 Jun 27. PubMed |
| Degradation of GSPT1 causes TP53-independent cell death in leukemia while sparing normal hematopoietic stem cells. Sellar RS, Sperling AS, Slabicki M, Gasser JA, McConkey ME, Donovan KA, Mageed N, Adams DN, Zou C, Miller PG, Dutta RK, Boettcher S, Lin AE, Sandoval B, Quevedo Barrios VA, Kovalcik V, Koeppel J, Henderson EK, Fink EC, Yang L, Chan A, Pokharel SP, Bergstrom EJ, Burt R, Udeshi ND, Carr SA, Fischer ES, Chen CW, Ebert BL. J Clin Invest. 2022 Aug 15;132(16). pii: 153514. doi: 10.1172/JCI153514. PubMed |
Optimal LentiCRISPR-Based System for Sequential CRISPR/Cas9 Screens.
Hutcheson RL, Hayes M, Sugden B.
ACS Synth Biol. 2022 Jun 29. doi: 10.1021/acssynbio.2c00152.
PubMed
Associated Plasmids |
| Endocytosed HIV-1 Envelope Glycoprotein Traffics to Rab14(+) Late Endosomes and Lysosomes to Regulate Surface Levels in T-Cell Lines. Hoffman HK, Aguilar RS, Clark AR, Groves NS, Pezeshkian N, Bruns MM, van Engelenburg SB. J Virol. 2022 Jul 27;96(14):e0076722. doi: 10.1128/jvi.00767-22. Epub 2022 Jun 30. PubMed |
| NCOA4-Mediated Ferritinophagy Is a Pancreatic Cancer Dependency via Maintenance of Iron Bioavailability for Iron-Sulfur Cluster Proteins. Santana-Codina N, Del Rey MQ, Kapner KS, Zhang H, Gikandi A, Malcolm C, Poupault C, Kuljanin M, John KM, Biancur DE, Chen B, Das NK, Lowder KE, Hennessey CJ, Huang W, Yang A, Shah YM, Nowak JA, Aguirre AJ, Mancias JD. Cancer Discov. 2022 Sep 2;12(9):2180-2197. doi: 10.1158/2159-8290.CD-22-0043. PubMed |
| The Key Network of mRNAs and miRNAs Regulated by HIF1A in Hypoxic Hepatocellular Carcinoma Cells. Liu T, Tang J, Li X, Lin Y, Yang Y, Ma K, Hui Z, Ma H, Qin Y, Lei H, Yang Y. Front Genet. 2022 Jun 14;13:857507. doi: 10.3389/fgene.2022.857507. eCollection 2022. PubMed |
| Polo-Like Kinase 1 Regulates Chromosomal Instability and Paclitaxel Resistance in Breast Cancer Cells. Quan M, Oh Y, Cho SY, Kim JH, Moon HG. J Breast Cancer. 2022 Jun;25(3):178-192. doi: 10.4048/jbc.2022.25.e28. PubMed |
| STAT and Janus kinase targeting by human herpesvirus 8 interferon regulatory factor in the suppression of type-I interferon signaling. Xiang Q, Yang Z, Nicholas J. PLoS Pathog. 2022 Jul 1;18(7):e1010676. doi: 10.1371/journal.ppat.1010676. eCollection 2022 Jul. PubMed |
| Acetyl-Coenzyme A Synthetase 2 Potentiates Macropinocytosis and Muscle Wasting Through Metabolic Reprogramming in Pancreatic Cancer. Zhou Z, Ren Y, Yang J, Liu M, Shi X, Luo W, Fung KM, Xu C, Bronze MS, Zhang Y, Houchen CW, Li M. Gastroenterology. 2022 Nov;163(5):1281-1293.e1. doi: 10.1053/j.gastro.2022.06.058. Epub 2022 Jun 28. PubMed |
| RanGTPase links nucleo-cytoplasmic transport to the recruitment of cargoes into small extracellular vesicles. Chavan S, Khuperkar D, Lonare A, Panigrahi S, Bellare J, Rapole S, Seshadri V, Joseph J. Cell Mol Life Sci. 2022 Jul 2;79(7):392. doi: 10.1007/s00018-022-04422-y. PubMed |
| Patient-Specific Sarcoma Organoids for Personalized Translational Research: Unification of the Operating Room with Rare Cancer Research and Clinical Implications. Forsythe SD, Sivakumar H, Erali RA, Wajih N, Li W, Shen P, Levine EA, Miller KE, Skardal A, Votanopoulos KI. Ann Surg Oncol. 2022 Nov;29(12):7354-7367. doi: 10.1245/s10434-022-12086-y. Epub 2022 Jul 3. PubMed |
| Cytokine-Mediated STAT3 Transcription Supports ATGL/CGI-58-Dependent Adipocyte Lipolysis in Cancer Cachexia. Gandhi AY, Yu J, Gupta A, Guo T, Iyengar P, Infante RE. Front Oncol. 2022 Jun 15;12:841758. doi: 10.3389/fonc.2022.841758. eCollection 2022. PubMed |
| Exploring high-resolution chromatin interaction changes and functional enhancers of myogenic marker genes during myogenic differentiation. Long K, Li X, Su D, Zeng S, Li H, Zhang Y, Zhang B, Yang W, Li P, Li X, Wang X, Tang Q, Lu L, Jin L, Ma J, Li M. J Biol Chem. 2022 Aug;298(8):102149. doi: 10.1016/j.jbc.2022.102149. Epub 2022 Jul 2. PubMed |
| PRC2-Inactivating Mutations in Cancer Enhance Cytotoxic Response to DNMT1-Targeted Therapy via Enhanced Viral Mimicry. Patel AJ, Warda S, Maag JLV, Misra R, Miranda-Roman MA, Pachai MR, Lee CJ, Li D, Wang N, Bayshtok G, Fishinevich E, Meng Y, Wong EWP, Yan J, Giff E, Pappalardi MB, McCabe MT, Fletcher JA, Rudin CM, Chandarlapaty S, Scandura JM, Koche RP, Glass JL, Antonescu CR, Zheng D, Chen Y, Chi P. Cancer Discov. 2022 Sep 2;12(9):2120-2139. doi: 10.1158/2159-8290.CD-21-1671. PubMed |
Spatial regulation of AMPK signaling revealed by a sensitive kinase activity reporter.
Schmitt DL, Curtis SD, Lyons AC, Zhang JF, Chen M, He CY, Mehta S, Shaw RJ, Zhang J.
Nat Commun. 2022 Jul 5;13(1):3856. doi: 10.1038/s41467-022-31190-x.
PubMed
Associated Plasmids |
| Differential Engraftment of Parental A20 PD-L1 WT and PD-L1 KO Leukemia Cells in Semiallogeneic Recipients in the Context of PD-L1/PD-1 Interaction and NK Cell-Mediated Hybrid Resistance. Del Rio ML, Perez-Simon JA, Rodriguez-Barbosa JI. Front Immunol. 2022 Jun 20;13:887348. doi: 10.3389/fimmu.2022.887348. eCollection 2022. PubMed |
| Serum bridging molecules drive candidal invasion of human but not mouse endothelial cells. Phan QT, Solis NV, Lin J, Swidergall M, Singh S, Liu H, Sheppard DC, Ibrahim AS, Mitchell AP, Filler SG. PLoS Pathog. 2022 Jul 7;18(7):e1010681. doi: 10.1371/journal.ppat.1010681. eCollection 2022 Jul. PubMed |
| Recruitment of the CoREST transcription repressor complexes by Nerve Growth factor IB-like receptor (Nurr1/NR4A2) mediates silencing of HIV in microglial cells. Ye F, Alvarez-Carbonell D, Nguyen K, Leskov K, Garcia-Mesa Y, Sreeram S, Valadkhan S, Karn J. PLoS Pathog. 2022 Jul 7;18(7):e1010110. doi: 10.1371/journal.ppat.1010110. eCollection 2022 Jul. PubMed |
| Milademetan is a highly potent MDM2 inhibitor in Merkel cell carcinoma. Ananthapadmanabhan V, Frost TC, Soroko KM, Knott A, Magliozzi BJ, Gokhale PC, Tirunagaru VG, Doebele RC, DeCaprio JA. JCI Insight. 2022 Jul 8;7(13). pii: 160513. doi: 10.1172/jci.insight.160513. PubMed |
| Efficient Correction of Oncogenic KRAS and TP53 Mutations through CRISPR Base Editing. Sayed S, Sidorova OA, Hennig A, Augsburg M, Cortes Vesga CP, Abohawya M, Schmitt LT, Surun D, Stange DE, Mircetic J, Buchholz F. Cancer Res. 2022 Sep 2;82(17):3002-3015. doi: 10.1158/0008-5472.CAN-21-2519. PubMed |
| Mast4 determines the cell fate of MSCs for bone and cartilage development. Kim P, Park J, Lee DJ, Mizuno S, Shinohara M, Hong CP, Jeong Y, Yun R, Park H, Park S, Yang KM, Lee MJ, Jang SP, Kim HY, Lee SJ, Song SU, Park KS, Tanaka M, Ohshima H, Cho JW, Sugiyama F, Takahashi S, Jung HS, Kim SJ. Nat Commun. 2022 Jul 8;13(1):3960. doi: 10.1038/s41467-022-31697-3. PubMed |
| 3D Chromatin Organization Involving MEIS1 Factor in the cis-Regulatory Landscape of GJB2. Le Nabec A, Blotas C, Briset A, Collobert M, Ferec C, Moisan S. Int J Mol Sci. 2022 Jun 23;23(13). pii: ijms23136964. doi: 10.3390/ijms23136964. PubMed |
| Alpha-1 Antitrypsin Reduces Disease Progression in a Mouse Model of Charcot-Marie-Tooth Type 1A: A Role for Decreased Inflammation and ADAM-17 Inhibition. Zhukovsky N, Silvano M, Filloux T, Gonzalez S, Krause KH. Int J Mol Sci. 2022 Jul 3;23(13):7405. doi: 10.3390/ijms23137405. PubMed |
Dissecting protein tyrosine phosphatase signaling by engineered chemogenetic control of its activity.
Fauser J, Huyot V, Matsche J, Szynal BN, Alexeev Y, Kota P, Karginov AV.
J Cell Biol. 2022 Aug 1;221(8). pii: 213352. doi: 10.1083/jcb.202111066. Epub 2022 Jul 13.
PubMed
Associated Plasmids |
| A Novel Homozygous Stop Mutation in IL23R Causes Mendelian Susceptibility to Mycobacterial Disease. Staels F, Lorenzetti F, De Keukeleere K, Willemsen M, Gerbaux M, Neumann J, Tousseyn T, Pasciuto E, De Munter P, Bossuyt X, Gijsbers R, Liston A, Humblet-Baron S, Schrijvers R. J Clin Immunol. 2022 Nov;42(8):1638-1652. doi: 10.1007/s10875-022-01320-7. Epub 2022 Jul 13. PubMed |
| Structural basis for acyl chain control over glycosphingolipid sorting and vesicular trafficking. Schmieder SS, Tatituri R, Anderson M, Kelly K, Lencer WI. Cell Rep. 2022 Jul 12;40(2):111063. doi: 10.1016/j.celrep.2022.111063. PubMed |
| Mislocalization of protein kinase A drives pathology in Cushing's syndrome. Omar MH, Byrne DP, Jones KN, Lakey TM, Collins KB, Lee KS, Daly LA, Forbush KA, Lau HT, Golkowski M, McKnight GS, Breault DT, Lefrancois-Martinez AM, Martinez A, Eyers CE, Baird GS, Ong SE, Smith FD, Eyers PA, Scott JD. Cell Rep. 2022 Jul 12;40(2):111073. doi: 10.1016/j.celrep.2022.111073. PubMed |
| Adipocyte lysoplasmalogenase TMEM86A regulates plasmalogen homeostasis and protein kinase A-dependent energy metabolism. Cho YK, Yoon YC, Im H, Son Y, Kim M, Saha A, Choi C, Lee J, Lee S, Kim JH, Kang YP, Jung YS, Ha HK, Seong JK, Granneman JG, Kwon SW, Lee YH. Nat Commun. 2022 Jul 14;13(1):4084. doi: 10.1038/s41467-022-31805-3. PubMed |
| CLP36 promotes p53 deficient sarcoma progression through suppression of atrophin-1 interacting protein-4 (AIP-4)-dependent degradation of YAP1. Lu Y, Mu Y, Chen J, Guan X, Guo L, Wu C. Theranostics. 2022 Jul 4;12(11):5051-5068. doi: 10.7150/thno.72365. eCollection 2022. PubMed |
| SGLT2 inhibitor dapagliflozin reduces endothelial dysfunction and microvascular damage during cardiac ischemia/reperfusion injury through normalizing the XO-SERCA2-CaMKII-coffilin pathways. Ma L, Zou R, Shi W, Zhou N, Chen S, Zhou H, Chen X, Wu Y. Theranostics. 2022 Jun 27;12(11):5034-5050. doi: 10.7150/thno.75121. eCollection 2022. PubMed |
| Oncogenic BRAF induces whole-genome doubling through suppression of cytokinesis. Darp R, Vittoria MA, Ganem NJ, Ceol CJ. Nat Commun. 2022 Jul 15;13(1):4109. doi: 10.1038/s41467-022-31899-9. PubMed |
| The surfaceome of multiple myeloma cells suggests potential immunotherapeutic strategies and protein markers of drug resistance. Ferguson ID, Patino-Escobar B, Tuomivaara ST, Lin YT, Nix MA, Leung KK, Kasap C, Ramos E, Nieves Vasquez W, Talbot A, Hale M, Naik A, Kishishita A, Choudhry P, Lopez-Girona A, Miao W, Wong SW, Wolf JL, Martin TG 3rd, Shah N, Vandenberg S, Prakash S, Besse L, Driessen C, Posey AD Jr, Mullins RD, Eyquem J, Wells JA, Wiita AP. Nat Commun. 2022 Jul 15;13(1):4121. doi: 10.1038/s41467-022-31810-6. PubMed |
| Deficiency of PPP6C protects TNF-induced necroptosis through activation of TAK1. Zou Y, Zheng Q, Jiang B, Liu Y, Xu Y, Ma L, Hu Z, Wu M, Song H. Cell Death Dis. 2022 Jul 16;13(7):618. doi: 10.1038/s41419-022-05076-1. PubMed |
| Phagocytosis mediated by the human granulocyte receptor CEACAM3 is limited by the receptor-type protein tyrosine phosphatase PTPRJ. Goob G, Adrian J, Cossu C, Hauck CR. J Biol Chem. 2022 Sep;298(9):102269. doi: 10.1016/j.jbc.2022.102269. Epub 2022 Jul 16. PubMed |
| Venetoclax synergizes with gilteritinib in FLT3 wild-type high-risk acute myeloid leukemia by suppressing MCL-1. Janssen M, Schmidt C, Bruch PM, Blank MF, Rohde C, Waclawiczek A, Heid D, Renders S, Gollner S, Vierbaum L, Besenbeck B, Herbst SA, Knoll M, Kolb C, Przybylla A, Weidenauer K, Ludwig AK, Fabre M, Gu M, Schlenk RF, Stolzel F, Bornhauser M, Rollig C, Platzbecker U, Baldus C, Serve H, Sauer T, Raffel S, Pabst C, Vassiliou G, Vick B, Jeremias I, Trumpp A, Krijgsveld J, Muller-Tidow C, Dietrich S. Blood. 2022 Dec 15;140(24):2594-2610. doi: 10.1182/blood.2021014241. PubMed |
| Stress-induced perturbations in intracellular amino acids reprogram mRNA translation in osmoadaptation independently of the ISR. Krokowski D, Jobava R, Szkop KJ, Chen CW, Fu X, Venus S, Guan BJ, Wu J, Gao Z, Banaszuk W, Tchorzewski M, Mu T, Ropelewski P, Merrick WC, Mao Y, Sevval AI, Miranda H, Qian SB, Manifava M, Ktistakis NT, Vourekas A, Jankowsky E, Topisirovic I, Larsson O, Hatzoglou M. Cell Rep. 2022 Jul 19;40(3):111092. doi: 10.1016/j.celrep.2022.111092. PubMed |
| Sculpting Rupture-Free Nuclear Shapes in Fibrous Environments. Jana A, Tran A, Gill A, Kiepas A, Kapania RK, Konstantopoulos K, Nain AS. Adv Sci (Weinh). 2022 Sep;9(25):e2203011. doi: 10.1002/advs.202203011. Epub 2022 Jul 21. PubMed |
| Wnt signaling regulates hepatocyte cell division by a transcriptional repressor cascade. Jin Y, Anbarchian T, Wu P, Sarkar A, Fish M, Peng WC, Nusse R. Proc Natl Acad Sci U S A. 2022 Jul 26;119(30):e2203849119. doi: 10.1073/pnas.2203849119. Epub 2022 Jul 22. PubMed |
| SMOC2 promotes an epithelial-mesenchymal transition and a pro-metastatic phenotype in epithelial cells of renal cell carcinoma origin. Feng D, Gao P, Henley N, Dubuissez M, Chen N, Laurin LP, Royal V, Pichette V, Gerarduzzi C. Cell Death Dis. 2022 Jul 22;13(7):639. doi: 10.1038/s41419-022-05059-2. PubMed |
| A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer. Kelly MR, Wisniewska K, Regner MJ, Lewis MW, Perreault AA, Davis ES, Phanstiel DH, Parker JS, Franco HL. Nat Commun. 2022 Jul 22;13(1):4247. doi: 10.1038/s41467-022-31919-8. PubMed |
| CSTF2 Promotes Hepatocarcinogenesis and Hepatocellular Carcinoma Progression via Aerobic Glycolysis. Chen Z, Hao W, Tang J, Gao WQ, Xu H. Front Oncol. 2022 Jul 8;12:897804. doi: 10.3389/fonc.2022.897804. eCollection 2022. PubMed |
| Nicotinamide riboside alleviates cisplatin-induced peripheral neuropathy via SIRT2 activation. Acklin S, Sadhukhan R, Du W, Patra M, Cholia R, Xia F. Neurooncol Adv. 2022 Jun 27;4(1):vdac101. doi: 10.1093/noajnl/vdac101. eCollection 2022 Jan-Dec. PubMed |
| Human papillomaviruses sensitize cells to DNA damage induced apoptosis by targeting the innate immune sensor cGAS. Gusho E, Laimins LA. PLoS Pathog. 2022 Jul 25;18(7):e1010725. doi: 10.1371/journal.ppat.1010725. eCollection 2022 Jul. PubMed |
Human 5-lipoxygenase regulates transcription by association to euchromatin.
Kreiss M, Oberlis J, Seuter S, Bischoff-Kont I, Surun D, Thomas D, Gobel T, Schmid T, Radmark O, Brandes RP, Furst R, Hafner AK, Steinhilber D.
Biochem Pharmacol. 2022 Jul 22:115187. doi: 10.1016/j.bcp.2022.115187.
PubMed
Associated Plasmids |
| cGAS inhibition alleviates Alu RNA-induced immune responses and cytotoxicity in retinal pigmented epithelium. Li J, Zhang F, Bian W, Chen Y, Liu J, Liu Z, Xiong Y, Wan X. Cell Biosci. 2022 Jul 25;12(1):116. doi: 10.1186/s13578-022-00854-y. PubMed |
Endogenous spacing enables co-processing of microRNAs and efficient combinatorial RNAi.
Amen AM, Loughran RM, Huang CH, Lew RJ, Ravi A, Guan Y, Schatoff EM, Dow LE, Emerling BM, Fellmann C.
Cell Rep Methods. 2022 Jun 21;2(7):100239. doi: 10.1016/j.crmeth.2022.100239. eCollection 2022 Jul 18.
PubMed
Associated Plasmids |
| Large-scale manipulation of promoter DNA methylation reveals context-specific transcriptional responses and stability. de Mendoza A, Nguyen TV, Ford E, Poppe D, Buckberry S, Pflueger J, Grimmer MR, Stolzenburg S, Bogdanovic O, Oshlack A, Farnham PJ, Blancafort P, Lister R. Genome Biol. 2022 Jul 26;23(1):163. doi: 10.1186/s13059-022-02728-5. PubMed |
| Induced Endothelial Cell-Integrated Liver Assembloids Promote Hepatic Maturation and Therapeutic Effect on Cholestatic Liver Fibrosis. Nam D, Park MR, Lee H, Bae SC, Gerovska D, Arauzo-Bravo MJ, Zaehres H, Scholer HR, Kim JB. Cells. 2022 Jul 19;11(14):2242. doi: 10.3390/cells11142242. PubMed |
| Silver Nanoparticles Selectively Treat Neurofibromatosis Type 1-Associated Malignant Peripheral Nerve Sheath Tumors in a Neurofibromin-Dependent Manner. Alewine G, Knight J, Ghantae A, Mamrega C, Attiah B, Coover RA, Fahrenholtz CD. J Pers Med. 2022 Jun 30;12(7):1080. doi: 10.3390/jpm12071080. PubMed |
Expanded ACE2 dependencies of diverse SARS-like coronavirus receptor binding domains.
Roelle SM, Shukla N, Pham AT, Bruchez AM, Matreyek KA.
PLoS Biol. 2022 Jul 27;20(7):e3001738. doi: 10.1371/journal.pbio.3001738.
PubMed
Associated Plasmids |
| Low lamin A levels enhance confined cell migration and metastatic capacity in breast cancer. Bell ES, Shah P, Zuela-Sopilniak N, Kim D, Varlet AA, Morival JLP, McGregor AL, Isermann P, Davidson PM, Elacqua JJ, Lakins JN, Vahdat L, Weaver VM, Smolka MB, Span PN, Lammerding J. Oncogene. 2022 Sep;41(36):4211-4230. doi: 10.1038/s41388-022-02420-9. Epub 2022 Jul 27. PubMed |
| PI3K drives the de novo synthesis of coenzyme A from vitamin B5. Dibble CC, Barritt SA, Perry GE, Lien EC, Geck RC, DuBois-Coyne SE, Bartee D, Zengeya TT, Cohen EB, Yuan M, Hopkins BD, Meier JL, Clohessy JG, Asara JM, Cantley LC, Toker A. Nature. 2022 Aug;608(7921):192-198. doi: 10.1038/s41586-022-04984-8. Epub 2022 Jul 27. PubMed |
| Astrocyte immunometabolic regulation of the tumour microenvironment drives glioblastoma pathogenicity. Perelroizen R, Philosof B, Budick-Harmelin N, Chernobylsky T, Ron A, Katzir R, Shimon D, Tessler A, Adir O, Gaoni-Yogev A, Meyer T, Krivitsky A, Shidlovsky N, Madi A, Ruppin E, Mayo L. Brain. 2022 Sep 14;145(9):3288-3307. doi: 10.1093/brain/awac222. PubMed |
| The green tea catechin EGCG provides proof-of-concept for a pan-coronavirus attachment inhibitor. LeBlanc EV, Colpitts CC. Sci Rep. 2022 Jul 28;12(1):12899. doi: 10.1038/s41598-022-17088-0. PubMed |
| Mapping subcellular localizations of unannotated microproteins and alternative proteins with MicroID. Na Z, Dai X, Zheng SJ, Bryant CJ, Loh KH, Su H, Luo Y, Buhagiar AF, Cao X, Baserga SJ, Chen S, Slavoff SA. Mol Cell. 2022 Aug 4;82(15):2900-2911.e7. doi: 10.1016/j.molcel.2022.06.035. Epub 2022 Jul 28. PubMed |
| Inhibition of acylglycerol kinase sensitizes DLBCL to venetoclax via upregulation of FOXO1-mediated BCL-2 expression. Ning N, Zhang S, Wu Q, Li X, Kuang D, Duan Y, Xia M, Liu H, Weng J, Ba H, Tang Z, Cheng X, Mei H, Huang L, Ao Q, Wang G, Hu Y, Laurence A, Wang J, Wang G, Yang XP. Theranostics. 2022 Jul 18;12(12):5537-5550. doi: 10.7150/thno.72786. eCollection 2022. PubMed |
| TGFBR3 supports anoikis through suppressing ATF4 signaling. Hsu YJ, Yin YJ, Tsai KF, Jian CC, Liang ZW, Hsu CY, Wang CC. J Cell Sci. 2022 Sep 1;135(17):jcs258396. doi: 10.1242/jcs.258396. Epub 2022 Aug 30. PubMed |
| ARMS/Kidins220 regulates nociception by controlling brain-derived neurotrophic factor secretion. Sanchez-Sanchez J, Vicente-Garcia C, Canada-Garcia D, Martin-Zanca D, Arevalo JC. Pain. 2023 Mar 1;164(3):563-576. doi: 10.1097/j.pain.0000000000002741. Epub 2022 Jul 29. PubMed |
| GIGYF1 disruption associates with autism and impaired IGF-1R signaling. Chen G, Yu B, Tan S, Tan J, Jia X, Zhang Q, Zhang X, Jiang Q, Hua Y, Han Y, Luo S, Hoekzema K, Bernier RA, Earl RK, Kurtz-Nelson EC, Idleburg MJ, Madan-Khetarpal S, Clark R, Sebastian J, Fernandez-Jaen A, Alvarez S, King SD, Ramos LL, Santos MLS, Martin DM, Brooks D, Symonds JD, Cutcutache I, Pan Q, Hu Z, Yuan L, Eichler EE, Xia K, Guo H. J Clin Invest. 2022 Oct 3;132(19):e159806. doi: 10.1172/JCI159806. PubMed |
| Phenotypic heterogeneity driven by plasticity of the intermediate EMT state governs disease progression and metastasis in breast cancer. Brown MS, Abdollahi B, Wilkins OM, Lu H, Chakraborty P, Ognjenovic NB, Muller KE, Jolly MK, Christensen BC, Hassanpour S, Pattabiraman DR. Sci Adv. 2022 Aug 5;8(31):eabj8002. doi: 10.1126/sciadv.abj8002. Epub 2022 Aug 3. PubMed |
| A non-canonical vitamin K cycle is a potent ferroptosis suppressor. Mishima E, Ito J, Wu Z, Nakamura T, Wahida A, Doll S, Tonnus W, Nepachalovich P, Eggenhofer E, Aldrovandi M, Henkelmann B, Yamada KI, Wanninger J, Zilka O, Sato E, Feederle R, Hass D, Maida A, Mourao ASD, Linkermann A, Geissler EK, Nakagawa K, Abe T, Fedorova M, Proneth B, Pratt DA, Conrad M. Nature. 2022 Aug;608(7924):778-783. doi: 10.1038/s41586-022-05022-3. Epub 2022 Aug 3. PubMed |
| TREM2 Promotes Immune Evasion by Mycobacterium tuberculosis in Human Macrophages. Dabla A, Liang YC, Rajabalee N, Irwin C, Moonen CGJ, Willis JV, Berton S, Sun J. mBio. 2022 Aug 30;13(4):e0145622. doi: 10.1128/mbio.01456-22. Epub 2022 Aug 4. PubMed |
| METTL14-dependent m(6)A modification controls iNKT cell development and function. Cao L, Morgun E, Genardi S, Visvabharathy L, Cui Y, Huang H, Wang CR. Cell Rep. 2022 Aug 2;40(5):111156. doi: 10.1016/j.celrep.2022.111156. PubMed |
| Size-dependent activation of CAR-T cells. Xiao Q, Zhang X, Tu L, Cao J, Hinrichs CS, Su X. Sci Immunol. 2022 Aug 5;7(74):eabl3995. doi: 10.1126/sciimmunol.abl3995. Epub 2022 Aug 5. PubMed |
| USP22 controls type III interferon signaling and SARS-CoV-2 infection through activation of STING. Karlowitz R, Stanifer ML, Roedig J, Andrieux G, Bojkova D, Bechtel M, Smith S, Kowald L, Schubert R, Boerries M, Cinatl J Jr, Boulant S, van Wijk SJL. Cell Death Dis. 2022 Aug 6;13(8):684. doi: 10.1038/s41419-022-05124-w. PubMed |
| IDH1 mutation activates mTOR signaling pathway, promotes cell proliferation and invasion in glioma cells. Avsar T, Kose TB, Oksal MD, Turan G, Kilic T. Mol Biol Rep. 2022 Oct;49(10):9241-9249. doi: 10.1007/s11033-022-07750-1. Epub 2022 Aug 7. PubMed |
| GDF15 and ACE2 stratify COVID-19 patients according to severity while ACE2 mutations increase infection susceptibility. Torrens-Mas M, Perello-Reus CM, Trias-Ferrer N, Ibarguen-Gonzalez L, Crespi C, Galmes-Panades AM, Navas-Enamorado C, Sanchez-Polo A, Pierola-Lopetegui J, Masmiquel L, Crespi LS, Barcelo C, Gonzalez-Freire M. Front Cell Infect Microbiol. 2022 Jul 22;12:942951. doi: 10.3389/fcimb.2022.942951. eCollection 2022. PubMed |
| Genome-wide screening identified SEC61A1 as an essential factor for mycolactone-dependent apoptosis in human premonocytic THP-1 cells. Kawashima A, Kiriya M, En J, Tanigawa K, Nakamura Y, Fujiwara Y, Luo Y, Maruyama K, Watanabe S, Goto M, Suzuki K. PLoS Negl Trop Dis. 2022 Aug 8;16(8):e0010672. doi: 10.1371/journal.pntd.0010672. eCollection 2022 Aug. PubMed |
| Cooperation of Striatin 3 and MAP4K4 promotes growth and tissue invasion. Migliavacca J, Zullig B, Capdeville C, Grotzer MA, Baumgartner M. Commun Biol. 2022 Aug 8;5(1):795. doi: 10.1038/s42003-022-03708-y. PubMed |
| c-Myc plays a critical role in the antileukemic activity of the Mcl-1-selective inhibitor AZD5991 in acute myeloid leukemia. Liu S, Qiao X, Wu S, Gai Y, Su Y, Edwards H, Wang Y, Lin H, Taub JW, Wang G, Ge Y. Apoptosis. 2022 Dec;27(11-12):913-928. doi: 10.1007/s10495-022-01756-7. Epub 2022 Aug 9. PubMed |
| Acute lymphoblastic leukemia necessitates GSH-dependent ferroptosis defenses to overcome FSP1-epigenetic silencing. Pontel LB, Bueno-Costa A, Morellato AE, Carvalho Santos J, Roue G, Esteller M. Redox Biol. 2022 Jul 31;55:102408. doi: 10.1016/j.redox.2022.102408. PubMed |
| Evidence for a HURP/EB free mixed-nucleotide zone in kinetochore-microtubules. Castrogiovanni C, Inchingolo AV, Harrison JU, Dudka D, Sen O, Burroughs NJ, McAinsh AD, Meraldi P. Nat Commun. 2022 Aug 10;13(1):4704. doi: 10.1038/s41467-022-32421-x. PubMed |
| Pan-cancer analysis combined with experimental validation revealed IL4I1 as an immunological and prognostic biomarker. Rao D, Yu C, Wang T, Sheng J, Lv E, Liang H, Huang W, Dong H. Int Immunopharmacol. 2022 Oct;111:109091. doi: 10.1016/j.intimp.2022.109091. Epub 2022 Aug 8. PubMed |
| Epigenetic reader SP140 loss of function drives Crohn's disease due to uncontrolled macrophage topoisomerases. Amatullah H, Fraschilla I, Digumarthi S, Huang J, Adiliaghdam F, Bonilla G, Wong LP, Rivard ME, Beauchamp C, Mercier V, Goyette P, Sadreyev RI, Anthony RM, Rioux JD, Jeffrey KL. Cell. 2022 Aug 18;185(17):3232-3247.e18. doi: 10.1016/j.cell.2022.06.048. Epub 2022 Aug 10. PubMed |
| Identifying cell receptors for the nanoparticle protein corona using genome screens. Ngo W, Wu JLY, Lin ZP, Zhang Y, Bussin B, Granda Farias A, Syed AM, Chan K, Habsid A, Moffat J, Chan WCW. Nat Chem Biol. 2022 Sep;18(9):1023-1031. doi: 10.1038/s41589-022-01093-5. Epub 2022 Aug 11. PubMed |
| BRD4 Inhibitor GNE-987 Exerts Anticancer Effects by Targeting Super-Enhancer-Related Gene LYL1 in Acute Myeloid Leukemia. Sang X, Zhang Y, Fang F, Gao L, Tao Y, Li X, Zhang Z, Wang J, Tian Y, Li Z, Yao D, Wu Y, Chu X, Zhang K, Ma L, Lu L, Chen Y, Yu J, Zhuo R, Wu S, Zhang Z, Pan J, Hu S. J Immunol Res. 2022 Aug 1;2022:7912484. doi: 10.1155/2022/7912484. eCollection 2022. PubMed |
| Rapid and selective generation of H(2)S within mitochondria protects against cardiac ischemia-reperfusion injury. Miljkovic JL, Burger N, Gawel JM, Mulvey JF, Norman AAI, Nishimura T, Tsujihata Y, Logan A, Sauchanka O, Caldwell ST, Morris JL, Prime TA, Warrington S, Prudent J, Bates GR, Aksentijevic D, Prag HA, James AM, Krieg T, Hartley RC, Murphy MP. Redox Biol. 2022 Aug 5;55:102429. doi: 10.1016/j.redox.2022.102429. PubMed |
| Long non-coding RNA DARS-AS1 promotes tumor progression by directly suppressing PACT-mediated cellular stress. Yang L, Lin K, Zhu L, Wang H, Teng S, Huang L, Zhou S, Zhang G, Lu ZJ, Wang D. Commun Biol. 2022 Aug 15;5(1):822. doi: 10.1038/s42003-022-03778-y. PubMed |
| Regional connectivity drove bidirectional transmission of SARS-CoV-2 in the Middle East during travel restrictions. Parker E, Anderson C, Zeller M, Tibi A, Havens JL, Laroche G, Benlarbi M, Ariana A, Robles-Sikisaka R, Latif AA, Watts A, Awidi A, Jaradat SA, Gangavarapu K, Ramesh K, Kurzban E, Matteson NL, Han AX, Hughes LD, McGraw M, Spencer E, Nicholson L, Khan K, Suchard MA, Wertheim JO, Wohl S, Cote M, Abdelnour A, Andersen KG, Abu-Dayyeh I. Nat Commun. 2022 Aug 15;13(1):4784. doi: 10.1038/s41467-022-32536-1. PubMed |
| EGR2 is a hub-gene in myocardial infarction and aggravates inflammation and apoptosis in hypoxia-induced cardiomyocytes. Bo Z, Huang S, Li L, Chen L, Chen P, Luo X, Shi F, Zhu B, Shen L. BMC Cardiovasc Disord. 2022 Aug 15;22(1):373. doi: 10.1186/s12872-022-02814-3. PubMed |
| CRISPRi-mediated knock-down of PRDM1/BLIMP1 programs central memory differentiation in ex vivo-expanded human T cells. Azadbakht M, Sayadmanesh A, Nazer N, Ahmadi A, Hemmati S, Mohammadzade H, Ebrahimi M, Baharvand H, Khalaj B, Aghamaali MR, Basiri M. Bioimpacts. 2022;12(4):337-347. doi: 10.34172/bi.2021.23522. Epub 2021 Dec 7. PubMed |
| Development of a mouse salivary gland-derived mesenchymal cell line for immunological studies of murine cytomegalovirus. White TM, Stanfield BA, Bonavita CM, Rudd JS, Cardin RD. PLoS One. 2022 Aug 17;17(8):e0265479. doi: 10.1371/journal.pone.0265479. eCollection 2022. PubMed |
| Transcriptomics, regulatory syntax, and enhancer identification in mesoderm-induced ESCs at single-cell resolution. Khateb M, Perovanovic J, Ko KD, Jiang K, Feng X, Acevedo-Luna N, Chal J, Ciuffoli V, Genzor P, Simone J, Haase AD, Pourquie O, Dell'Orso S, Sartorelli V. Cell Rep. 2022 Aug 16;40(7):111219. doi: 10.1016/j.celrep.2022.111219. PubMed |
| Endocytic membrane repair by ESCRT-III controls antigen export to the cytosol during antigen cross-presentation. Gros M, Segura E, Rookhuizen DC, Baudon B, Heurtebise-Chretien S, Burgdorf N, Maurin M, Kapp EA, Simpson RJ, Kozik P, Villadangos JA, Bertrand MJM, Burbage M, Amigorena S. Cell Rep. 2022 Aug 16;40(7):111205. doi: 10.1016/j.celrep.2022.111205. PubMed |
| Erythroid lineage-specific lentiviral RNAi vectors suitable for molecular functional studies and therapeutic applications. Bagchi A, Devaraju N, Chambayil K, Rajendiran V, Venkatesan V, Sayed N, Pai AA, Nath A, David E, Nakamura Y, Balasubramanian P, Srivastava A, Thangavel S, Mohankumar KM, Velayudhan SR. Sci Rep. 2022 Aug 18;12(1):14033. doi: 10.1038/s41598-022-13783-0. PubMed |
| Epithelial-mesenchymal reprogramming by KLF4-regulated Rictor expression contributes to metastasis of non-small cell lung cancer cells. Zhou H, Guan Q, Hou X, Liu L, Zhou L, Li W, Liu H. Int J Biol Sci. 2022 Jul 18;18(13):4869-4883. doi: 10.7150/ijbs.73548. eCollection 2022. PubMed |
De novo pyrimidine synthesis is a targetable vulnerability in IDH mutant glioma.
Shi DD, Savani MR, Levitt MM, Wang AC, Endress JE, Bird CE, Buehler J, Stopka SA, Regan MS, Lin YF, Puliyappadamba VT, Gao W, Khanal J, Evans L, Lee JH, Guo L, Xiao Y, Xu M, Huang B, Jennings RB, Bonal DM, Martin-Sandoval MS, Dang T, Gattie LC, Cameron AB, Lee S, Asara JM, Kornblum HI, Mak TW, Looper RE, Nguyen QD, Signoretti S, Gradl S, Sutter A, Jeffers M, Janzer A, Lehrman MA, Zacharias LG, Mathews TP, Losman JA, Richardson TE, Cahill DP, DeBerardinis RJ, Ligon KL, Xu L, Ly P, Agar NYR, Abdullah KG, Harris IS, Kaelin WG Jr, McBrayer SK.
Cancer Cell. 2022 Sep 12;40(9):939-956.e16. doi: 10.1016/j.ccell.2022.07.011. Epub 2022 Aug 18.
PubMed
Associated Plasmids |
| RBM47 is a Critical Regulator of Mouse Embryonic Stem Cell Differentiation. Shivalingappa PKM, Singh DK, Sharma V, Arora V, Shiras A, Bapat SA. Stem Cell Rev Rep. 2023 Feb;19(2):475-490. doi: 10.1007/s12015-022-10441-w. Epub 2022 Aug 20. PubMed |
| Toxoplasma effector-induced ICAM-1 expression by infected dendritic cells potentiates transmigration across polarised endothelium. Ross EC, Hoeve ALT, Saeij JPJ, Barragan A. Front Immunol. 2022 Aug 3;13:950914. doi: 10.3389/fimmu.2022.950914. eCollection 2022. PubMed |
| Protocol for the generation of HIV-1 genomic RNA with altered levels of N (6)-methyladenosine. Phillips S, Baek A, Kim S, Chen S, Wu L. STAR Protoc. 2022 Aug 10;3(3):101616. doi: 10.1016/j.xpro.2022.101616. eCollection 2022 Sep 16. PubMed |
| Identification of potent inhibitors of SARS-CoV-2 infection by combined pharmacological evaluation and cellular network prioritization. Patten JJ, Keiser PT, Morselli-Gysi D, Menichetti G, Mori H, Donahue CJ, Gan X, Valle ID, Geoghegan-Barek K, Anantpadma M, Boytz R, Berrigan JL, Stubbs SH, Ayazika T, O'Leary C, Jalloh S, Wagner F, Ayehunie S, Elledge SJ, Anderson D, Loscalzo J, Zitnik M, Gummuluru S, Namchuk MN, Barabasi AL, Davey RA. iScience. 2022 Sep 16;25(9):104925. doi: 10.1016/j.isci.2022.104925. Epub 2022 Aug 13. PubMed |
| RAB21 controls autophagy and cellular energy homeostasis by regulating retromer-mediated recycling of SLC2A1/GLUT1. Pei Y, Lv S, Shi Y, Jia J, Ma M, Han H, Zhang R, Tan J, Zhang X. Autophagy. 2023 Apr;19(4):1070-1086. doi: 10.1080/15548627.2022.2114271. Epub 2022 Aug 21. PubMed |
| Comparative chromatin accessibility upon BDNF stimulation delineates neuronal regulatory elements. Ibarra IL, Ratnu VS, Gordillo L, Hwang IY, Mariani L, Weinand K, Hammaren HM, Heck J, Bulyk ML, Savitski MM, Zaugg JB, Noh KM. Mol Syst Biol. 2022 Aug;18(8):e10473. doi: 10.15252/msb.202110473. PubMed |
| Human coronaviruses disassemble processing bodies. Kleer M, Mulloy RP, Robinson CA, Evseev D, Bui-Marinos MP, Castle EL, Banerjee A, Mubareka S, Mossman K, Corcoran JA. PLoS Pathog. 2022 Aug 23;18(8):e1010724. doi: 10.1371/journal.ppat.1010724. eCollection 2022 Aug. PubMed |
| Cytoplasmic keratins couple with and maintain nuclear envelope integrity in colonic epithelial cells. Stenvall CA, Nystrom JH, Butler-Hallissey C, Jansson T, Heikkila TRH, Adam SA, Foisner R, Goldman RD, Ridge KM, Toivola DM. Mol Biol Cell. 2022 Nov 1;33(13):ar121. doi: 10.1091/mbc.E20-06-0387. Epub 2022 Aug 24. PubMed |
Genetic evidence that uptake of the fluorescent analog 2NBDG occurs independently of known glucose transporters.
D'Souza LJ, Wright SH, Bhattacharya D.
PLoS One. 2022 Aug 24;17(8):e0261801. doi: 10.1371/journal.pone.0261801. eCollection 2022.
PubMed
Associated Plasmids |
| RASA2 ablation in T cells boosts antigen sensitivity and long-term function. Carnevale J, Shifrut E, Kale N, Nyberg WA, Blaeschke F, Chen YY, Li Z, Bapat SP, Diolaiti ME, O'Leary P, Vedova S, Belk J, Daniel B, Roth TL, Bachl S, Anido AA, Prinzing B, Ibanez-Vega J, Lange S, Haydar D, Luetke-Eversloh M, Born-Bony M, Hegde B, Kogan S, Feuchtinger T, Okada H, Satpathy AT, Shannon K, Gottschalk S, Eyquem J, Krenciute G, Ashworth A, Marson A. Nature. 2022 Sep;609(7925):174-182. doi: 10.1038/s41586-022-05126-w. Epub 2022 Aug 24. PubMed |
| Ammonium tetrathiomolybdate triggers autophagy-dependent NRF2 activation in vascular endothelial cells. Zhang M, Qiu H, Mao L, Wang B, Li N, Fan Y, Weng P, Hu S, Dong X, Qin X, Chen C, Zou Z, Yu C, Zhang J. Cell Death Dis. 2022 Aug 25;13(8):733. doi: 10.1038/s41419-022-05183-z. PubMed |
| MicroRNA-223 Suppresses Human Hepatic Stellate Cell Activation Partly via Regulating the Actin Cytoskeleton and Alleviates Fibrosis in Organoid Models of Liver Injury. Ariyachet C, Chuaypen N, Kaewsapsak P, Chantaravisoot N, Jindatip D, Potikanond S, Tangkijvanich P. Int J Mol Sci. 2022 Aug 19;23(16):9380. doi: 10.3390/ijms23169380. PubMed |
| Decoding Functional High-Density Lipoprotein Particle Surfaceome Interactions. Frey K, Goetze S, Rohrer L, von Eckardstein A, Wollscheid B. Int J Mol Sci. 2022 Aug 22;23(16):9506. doi: 10.3390/ijms23169506. PubMed |
| scRNA-seq reveals ATPIF1 activity in control of T cell antitumor activity. Zhong G, Wang Q, Wang Y, Guo Y, Xu M, Guan Y, Zhang X, Wu M, Xu Z, Zhao W, Lian H, Wang H, Ye J. Oncoimmunology. 2022 Aug 20;11(1):2114740. doi: 10.1080/2162402X.2022.2114740. eCollection 2022. PubMed |
| S146L in MYC is a context-dependent activating substitution in cancer development. Hinds JW, Feris EJ, Wilkins OM, Deary LT, Wang X, Cole MD. PLoS One. 2022 Aug 26;17(8):e0272771. doi: 10.1371/journal.pone.0272771. eCollection 2022. PubMed |
| Exploring the mechanistic link between SF3B1 mutation and ring sideroblast formation in myelodysplastic syndrome. Ochi T, Fujiwara T, Ono K, Suzuki C, Nikaido M, Inoue D, Kato H, Onodera K, Ichikawa S, Fukuhara N, Onishi Y, Yokoyama H, Nakamura Y, Harigae H. Sci Rep. 2022 Aug 26;12(1):14562. doi: 10.1038/s41598-022-18921-2. PubMed |
| Functional map of SARS-CoV-2 3CL protease reveals tolerant and immutable sites. Iketani S, Hong SJ, Sheng J, Bahari F, Culbertson B, Atanaki FF, Aditham AK, Kratz AF, Luck MI, Tian R, Goff SP, Montazeri H, Sabo Y, Ho DD, Chavez A. Cell Host Microbe. 2022 Oct 12;30(10):1354-1362.e6. doi: 10.1016/j.chom.2022.08.003. Epub 2022 Aug 11. PubMed |
| Trip13 Depletion in Liver Cancer Induces a Lipogenic Response Contributing to Plin2-Dependent Mitotic Cell Death. Rios Garcia M, Meissburger B, Chan J, de Guia RM, Mattijssen F, Roessler S, Birkenfeld AL, Raschzok N, Riols F, Tokarz J, Giroud M, Gil Lozano M, Hartleben G, Nawroth P, Haid M, Lopez M, Herzig S, Berriel Diaz M. Adv Sci (Weinh). 2022 Oct;9(29):e2104291. doi: 10.1002/advs.202104291. Epub 2022 Aug 28. PubMed |
| Integrated multi-omics analyses identify key anti-viral host factors and pathways controlling SARS-CoV-2 infection. Hou J, Wei Y, Zou J, Jaffery R, Liang S, Zheng C, Chen K, Shi PY, Chen Y, Xie X, Peng W. Res Sq. 2022 Aug 15:rs.3.rs-1910932. doi: 10.21203/rs.3.rs-1910932/v1. Preprint. PubMed |
| Akkermansia muciniphila upregulates genes involved in maintaining the intestinal barrier function via ADP-heptose-dependent activation of the ALPK1/TIFA pathway. Martin-Gallausiaux C, Garcia-Weber D, Lashermes A, Larraufie P, Marinelli L, Teixeira V, Rolland A, Beguet-Crespel F, Brochard V, Quatremare T, Jamet A, Dore J, Gray-Owen SD, Blottiere HM, Arrieumerlou C, Lapaque N. Gut Microbes. 2022 Jan-Dec;14(1):2110639. doi: 10.1080/19490976.2022.2110639. PubMed |
| DJ-1 is an essential downstream mediator in PINK1/parkin-dependent mitophagy. Imberechts D, Kinnart I, Wauters F, Terbeek J, Manders L, Wierda K, Eggermont K, Madeiro RF, Sue C, Verfaillie C, Vandenberghe W. Brain. 2022 Dec 19;145(12):4368-4384. doi: 10.1093/brain/awac313. PubMed |
VRK1 as a synthetic lethal target in VRK2 promoter-methylated cancers of the nervous system.
So J, Mabe NW, Englinger B, Chow KH, Moyer SM, Yerrum S, Trissal MC, Marques JG, Kwon JJ, Shim B, Pal S, Panditharatna E, Quinn T, Schaefer DA, Jeong D, Mayhew DL, Hwang J, Beroukhim R, Ligon KL, Stegmaier K, Filbin MG, Hahn WC.
JCI Insight. 2022 Oct 10;7(19):e158755. doi: 10.1172/jci.insight.158755.
PubMed
Associated Plasmids |
| SMNDC1 links chromatin remodeling and splicing to regulate pancreatic hormone expression. Casteels T, Bajew S, Reinis J, Enders L, Schuster M, Fontaine F, Muller AC, Wagner BK, Bock C, Kubicek S. Cell Rep. 2022 Aug 30;40(9):111288. doi: 10.1016/j.celrep.2022.111288. PubMed |
| RBM45 is an m(6)A-binding protein that affects neuronal differentiation and the splicing of a subset of mRNAs. Choi SH, Flamand MN, Liu B, Zhu H, Hu M, Wang M, Sewell J, Holley CL, Al-Hashimi HM, Meyer KD. Cell Rep. 2022 Aug 30;40(9):111293. doi: 10.1016/j.celrep.2022.111293. PubMed |
| DEPDC5-dependent mTORC1 signaling mechanisms are critical for the anti-seizure effects of acute fasting. Yuskaitis CJ, Modasia JB, Schrotter S, Rossitto LA, Groff KJ, Morici C, Mithal DS, Chakrabarty RP, Chandel NS, Manning BD, Sahin M. Cell Rep. 2022 Aug 30;40(9):111278. doi: 10.1016/j.celrep.2022.111278. PubMed |
Production of human entorhinal stellate cell-like cells by forward programming shows an important role of Foxp1 in reprogramming.
Bergmann T, Liu Y, Skov J, Mogus L, Lee J, Pfisterer U, Handfield LF, Asenjo-Martinez A, Lisa-Vargas I, Seemann SE, Lee JTH, Patikas N, Kornum BR, Denham M, Hyttel P, Witter MP, Gorodkin J, Pers TH, Hemberg M, Khodosevich K, Hall VJ.
Front Cell Dev Biol. 2022 Aug 15;10:976549. doi: 10.3389/fcell.2022.976549. eCollection 2022.
PubMed
Associated Plasmids |
| Piezo1 stimulates mitochondrial function via cAMP signaling. Li X, Kordsmeier J, Nookaew I, Kim HN, Xiong J. FASEB J. 2022 Oct;36(10):e22519. doi: 10.1096/fj.202200300R. PubMed |
| Genome-wide in vivo screen of circulating tumor cells identifies SLIT2 as a regulator of metastasis. Xia F, Ma Y, Chen K, Duong B, Ahmed S, Atwal R, Philpott D, Ketela T, Pantea J, Lin S, Angers S, Kelley SO. Sci Adv. 2022 Sep 2;8(35):eabo7792. doi: 10.1126/sciadv.abo7792. Epub 2022 Sep 2. PubMed |
| Protein import motor complex reacts to mitochondrial misfolding by reducing protein import and activating mitophagy. Michaelis JB, Brunstein ME, Bozkurt S, Alves L, Wegner M, Kaulich M, Pohl C, Munch C. Nat Commun. 2022 Sep 2;13(1):5164. doi: 10.1038/s41467-022-32564-x. PubMed |
| Induced hepatic stem cells maintain self-renewal through the high expression of Myc coregulated by TET1 and CTCF. Wang C, Yu X, Ding S, Liu Y, Zhang H, Fu J, Yu B, Zhu H. Cell Biosci. 2022 Sep 2;12(1):143. doi: 10.1186/s13578-022-00883-7. PubMed |
| Redox regulation of RAD51 Cys319 and homologous recombination by peroxiredoxin 1. Skoko JJ, Cao J, Gaboriau D, Attar M, Asan A, Hong L, Paulsen CE, Ma H, Liu Y, Wu H, Harkness T, Furdui CM, Manevich Y, Morrison CG, Brown ET, Normolle D, Spies M, Spies MA, Carroll K, Neumann CA. Redox Biol. 2022 Oct;56:102443. doi: 10.1016/j.redox.2022.102443. Epub 2022 Aug 24. PubMed |
Generation of dual-gRNA library for combinatorial CRISPR screening of synthetic lethal gene pairs.
Tang S, Wu X, Liu J, Zhang Q, Wang X, Shao S, Gokbag B, Fan K, Liu X, Li F, Cheng L, Li L.
STAR Protoc. 2022 Aug 24;3(3):101556. doi: 10.1016/j.xpro.2022.101556. eCollection 2022 Sep 16.
PubMed
Associated Plasmids |
| Massively parallel genomic perturbations with multi-target CRISPR interrogates Cas9 activity and DNA repair at endogenous sites. Zou RS, Marin-Gonzalez A, Liu Y, Liu HB, Shen L, Dveirin RK, Luo JXJ, Kalhor R, Ha T. Nat Cell Biol. 2022 Sep;24(9):1433-1444. doi: 10.1038/s41556-022-00975-z. Epub 2022 Sep 5. PubMed |
| Indisulam synergizes with palbociclib to induce senescence through inhibition of CDK2 kinase activity. Pogacar Z, Johnson JL, Krenning L, De Conti G, Jochems F, Lieftink C, Velds A, Wardak L, Groot K, Schepers A, Wang L, Song JY, van de Ven M, van Tellingen O, Medema RH, Beijersbergen RL, Bernards R, Leite de Oliveira R. PLoS One. 2022 Sep 6;17(9):e0273182. doi: 10.1371/journal.pone.0273182. eCollection 2022. PubMed |
| Accounting for small variations in the tracrRNA sequence improves sgRNA activity predictions for CRISPR screening. DeWeirdt PC, McGee AV, Zheng F, Nwolah I, Hegde M, Doench JG. Nat Commun. 2022 Sep 6;13(1):5255. doi: 10.1038/s41467-022-33024-2. PubMed |
| Multimodal single cell sequencing implicates chromatin accessibility and genetic background in diabetic kidney disease progression. Wilson PC, Muto Y, Wu H, Karihaloo A, Waikar SS, Humphreys BD. Nat Commun. 2022 Sep 6;13(1):5253. doi: 10.1038/s41467-022-32972-z. PubMed |
| Oncohistone interactome profiling uncovers contrasting oncogenic mechanisms and identifies potential therapeutic targets in high grade glioma. Siddaway R, Canty L, Pajovic S, Milos S, Coyaud E, Sbergio SG, Vadivel Anguraj AK, Lubanszky E, Yun HY, Portante A, Carette S, Zhang C, Moran MF, Raught B, Campos EI, Hawkins C. Acta Neuropathol. 2022 Nov;144(5):1027-1048. doi: 10.1007/s00401-022-02489-2. Epub 2022 Sep 7. PubMed |
| Runx2 regulates chromatin accessibility to direct the osteoblast program at neonatal stages. Hojo H, Saito T, He X, Guo Q, Onodera S, Azuma T, Koebis M, Nakao K, Aiba A, Seki M, Suzuki Y, Okada H, Tanaka S, Chung UI, McMahon AP, Ohba S. Cell Rep. 2022 Sep 6;40(10):111315. doi: 10.1016/j.celrep.2022.111315. PubMed |
| Genetic determinants of chromatin reveal prostate cancer risk mediated by context-dependent gene regulation. Baca SC, Singler C, Zacharia S, Seo JH, Morova T, Hach F, Ding Y, Schwarz T, Huang CF, Anderson J, Fay AP, Kalita C, Groha S, Pomerantz MM, Wang V, Linder S, Sweeney CJ, Zwart W, Lack NA, Pasaniuc B, Takeda DY, Gusev A, Freedman ML. Nat Genet. 2022 Sep;54(9):1364-1375. doi: 10.1038/s41588-022-01168-y. Epub 2022 Sep 7. PubMed |
| Rab35 governs apicobasal polarity through regulation of actin dynamics during sprouting angiogenesis. Francis CR, Kincross H, Kushner EJ. Nat Commun. 2022 Sep 8;13(1):5276. doi: 10.1038/s41467-022-32853-5. PubMed |
| Development and Characterization of a Luciferase Labeled, Syngeneic Murine Model of Ovarian Cancer. Russell S, Lim F, Peters PN, Wardell SE, Whitaker R, Chang CY, Previs RA, McDonnell DP. Cancers (Basel). 2022 Aug 30;14(17):4219. doi: 10.3390/cancers14174219. PubMed |
| Modeling Colorectal Cancer Progression Reveals Niche-Dependent Clonal Selection. Vaquero-Siguero N, Schleussner N, Volk J, Mastel M, Meier J, Jackstadt R. Cancers (Basel). 2022 Aug 31;14(17):4260. doi: 10.3390/cancers14174260. PubMed |
| Inhibition of Mcl-1 Synergistically Enhances the Antileukemic Activity of Gilteritinib and MRX-2843 in Preclinical Models of FLT3-Mutated Acute Myeloid Leukemia. Wu S, Edwards H, Wang D, Liu S, Qiao X, Carter J, Wang Y, Taub JW, Wang G, Ge Y. Cells. 2022 Sep 3;11(17):2752. doi: 10.3390/cells11172752. PubMed |
| Arsenal of nanobodies shows broad-spectrum neutralization against SARS-CoV-2 variants of concern in vitro and in vivo in hamster models. Rossotti MA, van Faassen H, Tran AT, Sheff J, Sandhu JK, Duque D, Hewitt M, Wen X, Bavananthasivam J, Beitari S, Matte K, Laroche G, Giguere PM, Gervais C, Stuible M, Guimond J, Perret S, Hussack G, Langlois MA, Durocher Y, Tanha J. Commun Biol. 2022 Sep 9;5(1):933. doi: 10.1038/s42003-022-03866-z. PubMed |
| Investigation of novel de novo KCNC2 variants causing severe developmental and early-onset epileptic encephalopathy. Li L, Liu Z, Yang H, Li Y, Zeng Q, Chen L, Liu Y, Chen Y, Zhu F, Cao D, Hu J, Shen X. Seizure. 2022 Oct;101:218-224. doi: 10.1016/j.seizure.2022.09.004. Epub 2022 Sep 5. PubMed |
| Cross-species comparisons reveal resistance of human skeletal stem cells to inhibition by non-steroidal anti-inflammatory drugs. Goodnough LH, Ambrosi TH, Steininger HM, Butler MGK, Hoover MY, Choo H, Van Rysselberghe NL, Bellino MJ, Bishop JA, Gardner MJ, Chan CKF. Front Endocrinol (Lausanne). 2022 Aug 25;13:924927. doi: 10.3389/fendo.2022.924927. eCollection 2022. PubMed |
| Live-cell imaging in human colonic monolayers reveals ERK waves limit the stem cell compartment to maintain epithelial homeostasis. Pond KW, Morris JM, Alkhimenok O, Varghese RP, Cabel CR, Ellis NA, Chakrabarti J, Zavros Y, Merchant JL, Thorne CA, Paek AL. Elife. 2022 Sep 12;11:e78837. doi: 10.7554/eLife.78837. PubMed |
| GCAF(TMEM251) regulates lysosome biogenesis by activating the mannose-6-phosphate pathway. Zhang W, Yang X, Li Y, Yu L, Zhang B, Zhang J, Cho WJ, Venkatarangan V, Chen L, Burugula BB, Bui S, Wang Y, Duan C, Kitzman JO, Li M. Nat Commun. 2022 Sep 12;13(1):5351. doi: 10.1038/s41467-022-33025-1. PubMed |
| Smc5/6 silences episomal transcription by a three-step function. Abdul F, Diman A, Baechler B, Ramakrishnan D, Kornyeyev D, Beran RK, Fletcher SP, Strubin M. Nat Struct Mol Biol. 2022 Sep;29(9):922-931. doi: 10.1038/s41594-022-00829-0. Epub 2022 Sep 12. PubMed |
| ACE2-containing defensosomes serve as decoys to inhibit SARS-CoV-2 infection. Ching KL, de Vries M, Gago J, Dancel-Manning K, Sall J, Rice WJ, Barnett C, Khodadadi-Jamayran A, Tsirigos A, Liang FX, Thorpe LE, Shopsin B, Segal LN, Dittmann M, Torres VJ, Cadwell K. PLoS Biol. 2022 Sep 13;20(9):e3001754. doi: 10.1371/journal.pbio.3001754. eCollection 2022 Sep. PubMed |
| Cisplatin and gemcitabine exert opposite effects on immunotherapy with PD-1 antibody in K-ras-driven cancer. Glorieux C, Xia X, You X, Wang Z, Han Y, Yang J, Noppe G, Meester C, Ling J, Robert A, Zhang H, Li SP, Wang H, Chiao PJ, Zhang L, Li X, Huang P. J Adv Res. 2022 Sep;40:109-124. doi: 10.1016/j.jare.2021.12.005. Epub 2021 Dec 21. PubMed |
| Pathogenic variants of sphingomyelin synthase SMS2 disrupt lipid landscapes in the secretory pathway. Sokoya T, Parolek J, Foged MM, Danylchuk DI, Bozan M, Sarkar B, Hilderink A, Philippi M, Botto LD, Terhal PA, Makitie O, Piehler J, Kim Y, Burd CG, Klymchenko AS, Maeda K, Holthuis JCM. Elife. 2022 Sep 14;11:e79278. doi: 10.7554/eLife.79278. PubMed |
| SerpinB3 drives cancer stem cell survival in glioblastoma. Lauko A, Volovetz J, Turaga SM, Bayik D, Silver DJ, Mitchell K, Mulkearns-Hubert EE, Watson DC, Desai K, Midha M, Hao J, McCortney K, Steffens A, Naik U, Ahluwalia MS, Bao S, Horbinski C, Yu JS, Lathia JD. Cell Rep. 2022 Sep 13;40(11):111348. doi: 10.1016/j.celrep.2022.111348. PubMed |
| A CHCHD6-APP axis connects amyloid and mitochondrial pathology in Alzheimer's disease. Shang Y, Sun X, Chen X, Wang Q, Wang EJ, Miller E, Xu R, Pieper AA, Qi X. Acta Neuropathol. 2022 Nov;144(5):911-938. doi: 10.1007/s00401-022-02499-0. Epub 2022 Sep 14. PubMed |
| Ceramide nanoliposomes augment the efficacy of venetoclax and cytarabine in models of acute myeloid leukemia. Khokhlatchev AV, Sharma A, Deering TG, Shaw JJP, Costa-Pinheiro P, Golla U, Annageldiyev C, Cabot MC, Conaway MR, Tan SF, Ung J, Feith DJ, Loughran TP Jr, Claxton DF, Fox TE, Kester M. FASEB J. 2022 Oct;36(10):e22514. doi: 10.1096/fj.202200765R. PubMed |
| Double-strand break toxicity is chromatin context independent. Friskes A, Koob L, Krenning L, Severson TM, Koeleman ES, Vergara X, Schubert M, van den Berg J, Evers B, Manjon AG, Joosten S, Kim Y, Zwart W, Medema RH. Nucleic Acids Res. 2022 Sep 23;50(17):9930-9947. doi: 10.1093/nar/gkac758. PubMed |
| Biphasic regulation of CFTR expression by ENaC in epithelial cells: The involvement of Ca(2+)-modulated cAMP production. Wuchu F, Ma X, Que Y, Chen J, Ruan YC. Front Cell Dev Biol. 2022 Aug 30;10:781762. doi: 10.3389/fcell.2022.781762. eCollection 2022. PubMed |
| Transposon Mutagenesis Reveals RBMS3 Silencing as a Promoter of Malignant Progression of BRAFV600E-Driven Lung Tumorigenesis. Vaishnavi A, Juan J, Jacob M, Stehn C, Gardner EE, Scherzer MT, Schuman S, Van Veen JE, Murphy B, Hackett CS, Dupuy AJ, Chmura SA, van der Weyden L, Newberg JY, Liu A, Mann K, Rust AG, Weiss WA, Kinsey CG, Adams DJ, Grossmann A, Mann MB, McMahon M. Cancer Res. 2022 Nov 15;82(22):4261-4273. doi: 10.1158/0008-5472.CAN-21-3214. PubMed |
Gain-of-function genetic screens in human cells identify SLC transporters overcoming environmental nutrient restrictions.
Rebsamen M, Girardi E, Sedlyarov V, Scorzoni S, Papakostas K, Vollert M, Konecka J, Guertl B, Klavins K, Wiedmer T, Superti-Furga G.
Life Sci Alliance. 2022 Sep 16;5(11):e202201404. doi: 10.26508/lsa.202201404. Print 2022 Nov.
PubMed
Associated Plasmids |
| CRISPR-Cas9 screen in human embryonic stem cells to identify genes required for neural differentiation. Qi S, Sivakumar S, Yu H. STAR Protoc. 2022 Dec 16;3(4):101682. doi: 10.1016/j.xpro.2022.101682. Epub 2022 Sep 16. PubMed |
| Oncogenic RAS commandeers amino acid sensing machinery to aberrantly activate mTORC1 in multiple myeloma. Yang Y, Bolomsky A, Oellerich T, Chen P, Ceribelli M, Haupl B, Wright GW, Phelan JD, Huang DW, Lord JW, Van Winkle CK, Yu X, Wisniewski J, Wang JQ, Tosto FA, Beck E, Wilson K, McKnight C, Travers J, Klumpp-Thomas C, Smith GA, Pittaluga S, Maric I, Kazandjian D, Thomas CJ, Young RM. Nat Commun. 2022 Sep 17;13(1):5469. doi: 10.1038/s41467-022-33142-x. PubMed |
| Reversal of IKZF1-induced glucocorticoid resistance by dual targeting of AKT and ERK signaling pathways. Butler M, Vervoort BMT, van Ingen Schenau DS, Jongeneel L, van der Zwet JCG, Marke R, Meijerink JPP, Scheijen B, van der Meer LT, van Leeuwen FN. Front Oncol. 2022 Sep 2;12:905665. doi: 10.3389/fonc.2022.905665. eCollection 2022. PubMed |
| SOX9 maintains human foetal lung tip progenitor state by enhancing WNT and RTK signalling. Sun D, Llora Batlle O, van den Ameele J, Thomas JC, He P, Lim K, Tang W, Xu C, Meyer KB, Teichmann SA, Marioni JC, Jackson SP, Brand AH, Rawlins EL. EMBO J. 2022 Nov 2;41(21):e111338. doi: 10.15252/embj.2022111338. Epub 2022 Sep 19. PubMed |
| Thiopurines inhibit coronavirus Spike protein processing and incorporation into progeny virions. Pringle ES, Duguay BA, Bui-Marinos MP, Mulloy RP, Landreth SL, Desireddy KS, Dolliver SM, Ying S, Caddell T, Tooley TH, Slaine PD, Bearne SL, Falzarano D, Corcoran JA, Khaperskyy DA, McCormick C. PLoS Pathog. 2022 Sep 19;18(9):e1010832. doi: 10.1371/journal.ppat.1010832. eCollection 2022 Sep. PubMed |
| Autophagy-linked plasma and lysosomal membrane protein PLAC8 is a key host factor for SARS-CoV-2 entry into human cells. Ugalde AP, Bretones G, Rodriguez D, Quesada V, Llorente F, Fernandez-Delgado R, Jimenez-Clavero MA, Vazquez J, Calvo E, Tamargo-Gomez I, Marino G, Roiz-Valle D, Maeso D, Araujo-Voces M, Espanol Y, Barcelo C, Freije JM, Lopez-Soto A, Lopez-Otin C. EMBO J. 2022 Nov 2;41(21):e110727. doi: 10.15252/embj.2022110727. Epub 2022 Oct 4. PubMed |
| GABP couples oncogene signaling to telomere regulation in TERT promoter mutant cancer. McKinney AM, Mathur R, Stevers NO, Molinaro AM, Chang SM, Phillips JJ, Costello JF. Cell Rep. 2022 Sep 20;40(12):111344. doi: 10.1016/j.celrep.2022.111344. PubMed |
| Snail maintains the stem/progenitor state of skin epithelial cells and carcinomas through the autocrine effect of matricellular protein Mindin. Badarinath K, Dam B, Kataria S, Zirmire RK, Dey R, Kansagara G, Ajnabi J, Hegde A, Singh R, Masudi T, Sambath J, Sachithanandan SP, Kumar P, Gulyani A, He YW, Krishna S, Jamora C. Cell Rep. 2022 Sep 20;40(12):111390. doi: 10.1016/j.celrep.2022.111390. PubMed |
| METTL16 antagonizes MRE11-mediated DNA end resection and confers synthetic lethality to PARP inhibition in pancreatic ductal adenocarcinoma. Zeng X, Zhao F, Cui G, Zhang Y, Deshpande RA, Chen Y, Deng M, Kloeber JA, Shi Y, Zhou Q, Zhang C, Hou J, Kim W, Tu X, Yan Y, Xu Z, Chen L, Gao H, Guo G, Liu J, Zhu Q, Cao Y, Huang J, Wu Z, Zhu S, Yin P, Luo K, Mer G, Paull TT, Yuan J, Tao K, Lou Z. Nat Cancer. 2022 Sep;3(9):1088-1104. doi: 10.1038/s43018-022-00429-3. Epub 2022 Sep 22. PubMed |
| SARS-CoV-2 Production, Purification Methods and UV Inactivation for Proteomics and Structural Studies. Plavec Z, Domanska A, Liu X, Laine P, Paulin L, Varjosalo M, Auvinen P, Wolf SG, Anastasina M, Butcher SJ. Viruses. 2022 Sep 8;14(9):1989. doi: 10.3390/v14091989. PubMed |
| The Bovine Seminal Plasma Protein PDC-109 Possesses Pan-Antiviral Activity. Sperber HS, Sutter K, Muller K, Muller P, Schwarzer R. Viruses. 2022 Sep 13;14(9):2031. doi: 10.3390/v14092031. PubMed |
| RBM15 condensates modulate m(6)A modification of STYK1 to promote tumorigenesis. Jiang A, Zhang S, Wang X, Li D. Comput Struct Biotechnol J. 2022 Sep 5;20:4825-4836. doi: 10.1016/j.csbj.2022.08.068. eCollection 2022. PubMed |
| A screening-compatible live cell fluorescence resonance energy transfer-based assay for modulation of Rho GTPase activity. Muller PM, Rocks O. STAR Protoc. 2022 Dec 16;3(4):101705. doi: 10.1016/j.xpro.2022.101705. Epub 2022 Sep 22. PubMed |
| Regulatory chromatin rewiring promotes metabolic switching during adaptation to oncogenic receptor tyrosine kinase inhibition. Ogden S, Carys K, Ahmed I, Bruce J, Sharrocks AD. Oncogene. 2022 Oct;41(43):4808-4822. doi: 10.1038/s41388-022-02465-w. Epub 2022 Sep 24. PubMed |
| Inhibition of HIV-1 replication using the CRISPR/cas9-no NLS system as a prophylactic strategy. Salimi-Jeda A, Esghaei M, Hossein Keyvani, Bokharaei-Salim F, Teimoori A, Abdoli A. Heliyon. 2022 Aug 31;8(9):e10483. doi: 10.1016/j.heliyon.2022.e10483. eCollection 2022 Sep. PubMed |
| A novel oncogenic enhancer of estrogen receptor-positive breast cancer. Bao C, Duan J, Xie Y, Liu Y, Li P, Li J, Zhao H, Guo H, Men Y, Ren Y, Xu J, Wang G, Lu W. Mol Ther Nucleic Acids. 2022 Aug 24;29:836-851. doi: 10.1016/j.omtn.2022.08.029. eCollection 2022 Sep 13. PubMed |
Quantification of Genome Editing and Transcriptional Control Capabilities Reveals Hierarchies among Diverse CRISPR/Cas Systems in Human Cells.
Escobar M, Li J, Patel A, Liu S, Xu Q, Hilton IB.
ACS Synth Biol. 2022 Oct 21;11(10):3239-3250. doi: 10.1021/acssynbio.2c00156. Epub 2022 Sep 26.
PubMed
Associated Plasmids |
| Altered-Self MHC Class I Sensing via Functionally Disparate Paired NK Cell Receptors Counters Murine Cytomegalovirus gp34-Mediated Immune Evasion. Cronk JM, Dziewulska KH, Puchalski P, Crittenden RB, Hammarskjold ML, Brown MG. J Immunol. 2022 Oct 15;209(8):1545-1554. doi: 10.4049/jimmunol.2200441. Epub 2022 Sep 7. PubMed |
| Resurrecting essential amino acid biosynthesis in mammalian cells. Trolle J, McBee RM, Kaufman A, Pinglay S, Berger H, German S, Liu L, Shen MJ, Guo X, Martin JA, Pacold ME, Jones DR, Boeke JD, Wang HH. Elife. 2022 Sep 27;11:e72847. doi: 10.7554/eLife.72847. PubMed |
Translational enhancement by base editing of the Kozak sequence rescues haploinsufficiency.
Ambrosini C, Destefanis E, Kheir E, Broso F, Alessandrini F, Longhi S, Battisti N, Pesce I, Dassi E, Petris G, Cereseto A, Quattrone A.
Nucleic Acids Res. 2022 Oct 14;50(18):10756-10771. doi: 10.1093/nar/gkac799.
PubMed
Associated Plasmids |
| Generation of a recombinant version of a biologically active cell-permeant human HAND2 transcription factor from E. coli. Haridhasapavalan KK, Sundaravadivelu PK, Joshi N, Das NJ, Mohapatra A, Voorkara U, Kaveeshwar V, Thummer RP. Sci Rep. 2022 Sep 27;12(1):16129. doi: 10.1038/s41598-022-19745-w. PubMed |
| BRD4 PROTAC degrader MZ1 exerts anticancer effects in acute myeloid leukemia by targeting c-Myc and ANP32B genes. Ma L, Wang J, Zhang Y, Fang F, Ling J, Chu X, Zhang Z, Tao Y, Li X, Tian Y, Li Z, Sang X, Zhang K, Lu L, Wan X, Chen Y, Yu J, Zhuo R, Wu S, Lu J, Pan J, Hu S. Cancer Biol Ther. 2022 Dec 31;23(1):1-15. doi: 10.1080/15384047.2022.2125748. PubMed |
| Dengue activates mTORC2 signaling to counteract apoptosis and maximize viral replication. Carter CC, Mast FD, Olivier JP, Bourgeois NM, Kaushansky A, Aitchison JD. Front Cell Infect Microbiol. 2022 Sep 12;12:979996. doi: 10.3389/fcimb.2022.979996. eCollection 2022. PubMed |
| A cancer stem cell associated gene signature for predicting overall survival of hepatocellular carcinoma. Liang XY, Zhang Y, He YN, Liu XY, Ding ZH, Zhang XD, Dong MY, Du RL. Front Genet. 2022 Sep 12;13:888601. doi: 10.3389/fgene.2022.888601. eCollection 2022. PubMed |
| Host specific sensing of coronaviruses and picornaviruses by the CARD8 inflammasome. Tsu BV, Agarwal R, Gokhale NS, Kulsuptrakul J, Ryan AP, Castro LK, Beierschmitt CM, Turcotte EA, Fay EJ, Vance RE, Hyde JL, Savan R, Mitchell PS, Daugherty MD. bioRxiv. 2022 Sep 22:2022.09.21.508960. doi: 10.1101/2022.09.21.508960. Preprint. PubMed |
| Mucosal nanobody IgA as inhalable and affordable prophylactic and therapeutic treatment against SARS-CoV-2 and emerging variants. Li Q, Humphries F, Girardin RC, Wallace A, Ejemel M, Amcheslavsky A, McMahon CT, Schiller ZA, Ma Z, Cruz J, Dupuis AP, Payne AF, Maryam A, Yilmaz NK, McDonough KA, Pierce BG, Schiffer CA, Kruse AC, Klempner MS, Cavacini LA, Fitzgerald KA, Wang Y. Front Immunol. 2022 Sep 12;13:995412. doi: 10.3389/fimmu.2022.995412. eCollection 2022. PubMed |
A feedback loop between lamellipodial extension and HGF-ERK signaling specifies leader cells during collective cell migration.
Hino N, Matsuda K, Jikko Y, Maryu G, Sakai K, Imamura R, Tsukiji S, Aoki K, Terai K, Hirashima T, Trepat X, Matsuda M.
Dev Cell. 2022 Oct 10;57(19):2290-2304.e7. doi: 10.1016/j.devcel.2022.09.003. Epub 2022 Sep 28.
PubMed
Associated Plasmids |
| Human immunoglobulin repertoire analysis guides design of vaccine priming immunogens targeting HIV V2-apex broadly neutralizing antibody precursors. Willis JR, Berndsen ZT, Ma KM, Steichen JM, Schiffner T, Landais E, Liguori A, Kalyuzhniy O, Allen JD, Baboo S, Omorodion O, Diedrich JK, Hu X, Georgeson E, Phelps N, Eskandarzadeh S, Groschel B, Kubitz M, Adachi Y, Mullin TM, Alavi NB, Falcone S, Himansu S, Carfi A, Wilson IA, Yates JR 3rd, Paulson JC, Crispin M, Ward AB, Schief WR. Immunity. 2022 Nov 8;55(11):2149-2167.e9. doi: 10.1016/j.immuni.2022.09.001. Epub 2022 Sep 29. PubMed |
| Targeting inflammatory macrophages rebuilds therapeutic efficacy of DOT1L inhibition in hepatocellular carcinoma. Yang YB, Wu CY, Wang XY, Deng J, Cao WJ, Tang YZ, Wan CC, Chen ZT, Zhan WY, Shan H, Kuang DM, Wei Y. Mol Ther. 2023 Jan 4;31(1):105-118. doi: 10.1016/j.ymthe.2022.09.019. Epub 2022 Sep 30. PubMed |
| Induced retinal pigment epithelial cells with anti-epithelial-to-mesenchymal transition ability delay retinal degeneration. Tian H, Chen Z, Zhu X, Ou Q, Wang Z, Wu B, Xu JY, Jin C, Gao F, Wang J, Zhang J, Zhang J, Lu L, Xu GT. iScience. 2022 Sep 2;25(10):105050. doi: 10.1016/j.isci.2022.105050. eCollection 2022 Oct 21. PubMed |
| Expression of vimentin alters cell mechanics, cell-cell adhesion, and gene expression profiles suggesting the induction of a hybrid EMT in human mammary epithelial cells. Sivagurunathan S, Vahabikashi A, Yang H, Zhang J, Vazquez K, Rajasundaram D, Politanska Y, Abdala-Valencia H, Notbohm J, Guo M, Adam SA, Goldman RD. Front Cell Dev Biol. 2022 Sep 19;10:929495. doi: 10.3389/fcell.2022.929495. eCollection 2022. PubMed |
| Cisplatin-induced HSF1-HSP90 axis enhances the expression of functional PD-L1 in oral squamous cell carcinoma. Sasaya T, Kubo T, Murata K, Mizue Y, Sasaki K, Yanagawa J, Imagawa M, Kato H, Tsukahara T, Kanaseki T, Tamura Y, Miyazaki A, Hirohashi Y, Torigoe T. Cancer Med. 2023 Feb;12(4):4605-4615. doi: 10.1002/cam4.5310. Epub 2022 Oct 6. PubMed |
| Vitamin C epigenetically controls osteogenesis and bone mineralization. Thaler R, Khani F, Sturmlechner I, Dehghani SS, Denbeigh JM, Zhou X, Pichurin O, Dudakovic A, Jerez SS, Zhong J, Lee JH, Natarajan R, Kalajzic I, Jiang YH, Deyle DR, Paschalis EP, Misof BM, Ordog T, van Wijnen AJ. Nat Commun. 2022 Oct 6;13(1):5883. doi: 10.1038/s41467-022-32915-8. PubMed |
| Lineage-coupled clonal capture identifies clonal evolution mechanisms and vulnerabilities of BRAF(V600E) inhibition resistance in melanoma. Zhang ZY, Ding Y, Ezhilarasan R, Lhakhang T, Wang Q, Yang J, Modrek AS, Zhang H, Tsirigos A, Futreal A, Draetta GF, Verhaak RGW, Sulman EP. Cell Discov. 2022 Oct 6;8(1):102. doi: 10.1038/s41421-022-00462-7. PubMed |
| AZIN1 RNA editing alters protein interactions, leading to nuclear translocation and worse outcomes in prostate cancer. Ghalali A, Wang L, Stopsack KH, Rice JM, Wu S, Wu CL, Zetter BR, Rogers MS. Exp Mol Med. 2022 Oct;54(10):1713-1726. doi: 10.1038/s12276-022-00845-6. Epub 2022 Oct 6. PubMed |
| Oncogenic role of a developmentally regulated NTRK2 splice variant. Pattwell SS, Arora S, Nuechterlein N, Zager M, Loeb KR, Cimino PJ, Holland NC, Reche-Ley N, Bolouri H, Almiron Bonnin DA, Szulzewsky F, Phadnis VV, Ozawa T, Wagner MJ, Haffner MC, Cao J, Shendure J, Holland EC. Sci Adv. 2022 Oct 7;8(40):eabo6789. doi: 10.1126/sciadv.abo6789. Epub 2022 Oct 7. PubMed |
| CD59-Regulated Ras Compartmentalization Orchestrates Antitumor T-cell Immunity. Li L, Ding P, Lv X, Xie S, Li L, Chen J, Zhou D, Wang X, Wang Q, Zhang W, Xu Y, Lu R, Hu W. Cancer Immunol Res. 2022 Dec 2;10(12):1475-1489. doi: 10.1158/2326-6066.CIR-21-1072. PubMed |
| Deficiency of the frontotemporal dementia gene GRN results in gangliosidosis. Boland S, Swarup S, Ambaw YA, Malia PC, Richards RC, Fischer AW, Singh S, Aggarwal G, Spina S, Nana AL, Grinberg LT, Seeley WW, Surma MA, Klose C, Paulo JA, Nguyen AD, Harper JW, Walther TC, Farese RV Jr. Nat Commun. 2022 Oct 7;13(1):5924. doi: 10.1038/s41467-022-33500-9. PubMed |
| CAMSAP2 promotes colorectal cancer cell migration and invasion through activation of JNK/c-Jun/MMP-1 signaling pathway. Wang X, Liu Y, Ding Y, Feng G. Sci Rep. 2022 Oct 7;12(1):16899. doi: 10.1038/s41598-022-21345-7. PubMed |
| Activity-regulated E3 ubiquitin ligase TRIM47 modulates excitatory synapse development. Sharma G, Banerjee S. Front Mol Neurosci. 2022 Sep 21;15:943980. doi: 10.3389/fnmol.2022.943980. eCollection 2022. PubMed |
| A genome-wide screen identifies SCAI as a modulator of the UV-induced replicative stress response. Lemay JF, St-Hilaire E, Ronato DA, Gao Y, Belanger F, Gezzar-Dandashi S, Kimenyi Ishimwe AB, Sawchyn C, Levesque D, McQuaid M, Boisvert FM, Mallette FA, Masson JY, Drobetsky EA, Wurtele H. PLoS Biol. 2022 Oct 10;20(10):e3001543. doi: 10.1371/journal.pbio.3001543. eCollection 2022 Oct. PubMed |
| Tetraspanin-5-mediated MHC class I clustering is required for optimal CD8 T cell activation. Colbert JD, Cruz FM, Baer CE, Rock KL. Proc Natl Acad Sci U S A. 2022 Oct 18;119(42):e2122188119. doi: 10.1073/pnas.2122188119. Epub 2022 Oct 10. PubMed |
| A genetically encoded system for oxygen generation in living cells. Markhard AL, McCoy JG, To TL, Mootha VK. Proc Natl Acad Sci U S A. 2022 Oct 25;119(43):e2207955119. doi: 10.1073/pnas.2207955119. Epub 2022 Oct 10. PubMed |
Systematic discovery of recombinases for efficient integration of large DNA sequences into the human genome.
Durrant MG, Fanton A, Tycko J, Hinks M, Chandrasekaran SS, Perry NT, Schaepe J, Du PP, Lotfy P, Bassik MC, Bintu L, Bhatt AS, Hsu PD.
Nat Biotechnol. 2022 Oct 10. pii: 10.1038/s41587-022-01494-w. doi: 10.1038/s41587-022-01494-w.
PubMed
Associated Plasmids |
| Fast generation of forebrain oligodendrocyte spheroids from human embryonic stem cells by transcription factors. Ma L, Mei Y, Xu P, Cheng Y, You Z, Ji X, Zhuang D, Zhou W, Chen Y, Xiong M. iScience. 2022 Sep 20;25(10):105172. doi: 10.1016/j.isci.2022.105172. eCollection 2022 Oct 21. PubMed |
| Human Cytomegalovirus Utilizes Multiple Viral Proteins to Regulate the Basement Membrane Protein Nidogen 1. Kuan MI, Caruso LB, Zavala AG, Rana PSJB, O'Dowd JM, Tempera I, Fortunato EA. J Virol. 2022 Oct 26;96(20):e0133622. doi: 10.1128/jvi.01336-22. Epub 2022 Oct 11. PubMed |
| SERINC5 restricts influenza virus infectivity. Zhao F, Xu F, Liu X, Hu Y, Wei L, Fan Z, Wang L, Huang Y, Mei S, Guo L, Yang L, Cen S, Wang J, Liang C, Guo F. PLoS Pathog. 2022 Oct 12;18(10):e1010907. doi: 10.1371/journal.ppat.1010907. eCollection 2022 Oct. PubMed |
| Lineage-selective super enhancers mediate core regulatory circuitry during adipogenic and osteogenic differentiation of human mesenchymal stem cells. Wang C, Tian W, Hu SY, Di CX, He CY, Cao QL, Hao RH, Dong SS, Liu CC, Rong Y, Kang HF, Yang TL, Yang Z, Guo Y. Cell Death Dis. 2022 Oct 12;13(10):866. doi: 10.1038/s41419-022-05309-3. PubMed |
| A dominant negative mitofusin causes mitochondrial perinuclear clusters because of aberrant tethering. Sloat SR, Hoppins S. Life Sci Alliance. 2022 Oct 13;6(1):e202101305. doi: 10.26508/lsa.202101305. Print 2023 Jan. PubMed |
| Early Mechanisms of Chemoresistance in Retinoblastoma. Zhang MG, Kuznetsoff JN, Owens DA, Gallo RA, Kalahasty K, Cruz AM, Kurtenbach S, Correa ZM, Pelaez D, Harbour JW. Cancers (Basel). 2022 Oct 10;14(19):4966. doi: 10.3390/cancers14194966. PubMed |
| A novel protein RASON encoded by a lncRNA controls oncogenic RAS signaling in KRAS mutant cancers. Cheng R, Li F, Zhang M, Xia X, Wu J, Gao X, Zhou H, Zhang Z, Huang N, Yang X, Zhang Y, Shen S, Kang T, Liu Z, Xiao F, Yao H, Xu J, Yan C, Zhang N. Cell Res. 2023 Jan;33(1):30-45. doi: 10.1038/s41422-022-00726-7. Epub 2022 Oct 14. PubMed |
| HERC2 deficiency activates C-RAF/MKK3/p38 signalling pathway altering the cellular response to oxidative stress. Sala-Gaston J, Pedrazza L, Ramirez J, Martinez-Martinez A, Rawlins LE, Baple EL, Crosby AH, Mayor U, Ventura F, Rosa JL. Cell Mol Life Sci. 2022 Oct 14;79(11):548. doi: 10.1007/s00018-022-04586-7. PubMed |
| ATF4-dependent fructolysis fuels growth of glioblastoma multiforme. Chen C, Zhang Z, Liu C, Wang B, Liu P, Fang S, Yang F, You Y, Li X. Nat Commun. 2022 Oct 16;13(1):6108. doi: 10.1038/s41467-022-33859-9. PubMed |
| MYC-mediated silencing of miR-181a-5p promotes pathogenic Th17 responses by modulating AKT3-FOXO3 signaling. Chen S, Ma B, Li X, Zhang K, Wei Y, Du B, Liu X, Wei R, Li X, Nian H. iScience. 2022 Sep 23;25(10):105176. doi: 10.1016/j.isci.2022.105176. eCollection 2022 Oct 21. PubMed |
| Polarized NHE1 and SWELL1 regulate migration direction, efficiency and metastasis. Zhang Y, Li Y, Thompson KN, Stoletov K, Yuan Q, Bera K, Lee SJ, Zhao R, Kiepas A, Wang Y, Mistriotis P, Serra SA, Lewis JD, Valverde MA, Martin SS, Sun SX, Konstantopoulos K. Nat Commun. 2022 Oct 17;13(1):6128. doi: 10.1038/s41467-022-33683-1. PubMed |
| Darinaparsin (ZIO-101) enhances the sensitivity of small-cell lung cancer to PARP inhibitors. Cao GZ, Ma LY, Zhang ZH, Wang XL, Hua JH, Zhang JH, Lv Y, Zhang SB, Ou J, Lin WC. Acta Pharmacol Sin. 2023 Apr;44(4):841-852. doi: 10.1038/s41401-022-00994-4. Epub 2022 Oct 17. PubMed |
Identification and differential usage of a host metalloproteinase entry pathway by SARS-CoV-2 Delta and Omicron.
Benlarbi M, Laroche G, Fink C, Fu K, Mulloy RP, Phan A, Ariana A, Stewart CM, Prevost J, Beaudoin-Bussieres G, Daniel R, Bo Y, El Ferri O, Yockell-Lelievre J, Stanford WL, Giguere PM, Mubareka S, Finzi A, Dekaban GA, Dikeakos JD, Cote M.
iScience. 2022 Nov 18;25(11):105316. doi: 10.1016/j.isci.2022.105316. Epub 2022 Oct 10.
PubMed
Associated Plasmids |
| DNA damage contributes to age-associated differences in SARS-CoV-2 infection. Jin R, Niu C, Wu F, Zhou S, Han T, Zhang Z, Li E, Zhang X, Xu S, Wang J, Tian S, Chen W, Ye Q, Cao C, Cheng L. Aging Cell. 2022 Dec;21(12):e13729. doi: 10.1111/acel.13729. Epub 2022 Oct 18. PubMed |
| Spatial modeling reveals nuclear phosphorylation and subcellular shuttling of YAP upon drug-induced liver injury. Wehling L, Keegan L, Fernandez-Palanca P, Hassan R, Ghallab A, Schmitt J, Tang Y, Le Marois M, Roessler S, Schirmacher P, Kummer U, Hengstler JG, Sahle S, Breuhahn K. Elife. 2022 Oct 18;11:e78540. doi: 10.7554/eLife.78540. PubMed |
| Protection of Regulatory T Cells from Fragility and Inactivation in the Tumor Microenvironment. Zhang H, Tomar VS, Li J, Basavaraja R, Yan F, Gui J, McBrearty N, Costich TL, Beiting DP, Blanco MA, Conejo-Garcia JR, Saggu G, Berger A, Nefedova Y, Gabrilovich DI, Fuchs SY. Cancer Immunol Res. 2022 Dec 2;10(12):1490-1505. doi: 10.1158/2326-6066.CIR-22-0295. PubMed |
| A Genome-Wide CRISPR-Cas9 Loss-of-Function Screening to Identify Host Restriction Factors Modulating Oncolytic Virotherapy. Muscolini M, Hiscott J, Tassone E. Methods Mol Biol. 2023;2589:379-399. doi: 10.1007/978-1-0716-2788-4_25. PubMed |
| Circadian lncRNA ADIRF-AS1 binds PBAF and regulates renal clear cell tumorigenesis. Brooks R, Monzy J, Aaron B, Zhang X, Kossenkov A, Hayden J, Keeney F, Speicher DW, Zhang L, Dang CV. Cell Rep. 2022 Oct 18;41(3):111514. doi: 10.1016/j.celrep.2022.111514. PubMed |
| A Molecular Switch between Mammalian MLL Complexes Dictates Response to Menin-MLL Inhibition. Soto-Feliciano YM, Sanchez-Rivera FJ, Perner F, Barrows DW, Kastenhuber ER, Ho YJ, Carroll T, Xiong Y, Anand D, Soshnev AA, Gates L, Beytagh MC, Cheon D, Gu S, Liu XS, Krivtsov AV, Meneses M, de Stanchina E, Stone RM, Armstrong SA, Lowe SW, Allis CD. Cancer Discov. 2023 Jan 9;13(1):146-169. doi: 10.1158/2159-8290.CD-22-0416. PubMed |
| Non-enzymatic role of SOD1 in intestinal stem cell growth. Wang YC, Leng XX, Zhou CB, Lu SY, Tsang CK, Xu J, Zhang MM, Chen HM, Fang JY. Cell Death Dis. 2022 Oct 20;13(10):882. doi: 10.1038/s41419-022-05267-w. PubMed |
| KCNQ1OT1 promotes genome-wide transposon repression by guiding RNA-DNA triplexes and HP1 binding. Zhang X, Jiang Q, Li J, Zhang S, Cao Y, Xia X, Cai D, Tan J, Chen J, Han JJ. Nat Cell Biol. 2022 Nov;24(11):1617-1629. doi: 10.1038/s41556-022-01008-5. Epub 2022 Oct 20. PubMed |
| Global mapping of GalNAc-T isoform-specificities and O-glycosylation site-occupancy in a tissue-forming human cell line. Nielsen MI, de Haan N, Kightlinger W, Ye Z, Dabelsteen S, Li M, Jewett MC, Bagdonaite I, Vakhrushev SY, Wandall HH. Nat Commun. 2022 Oct 21;13(1):6257. doi: 10.1038/s41467-022-33806-8. PubMed |
| Dissecting super-enhancer driven transcriptional dependencies reveals novel therapeutic strategies and targets for group 3 subtype medulloblastoma. Li M, Han Y, Wang C, Kang W, Jiang W, Zhang L, Tang Y. J Exp Clin Cancer Res. 2022 Oct 22;41(1):311. doi: 10.1186/s13046-022-02506-y. PubMed |
| SCF(FBXW7) regulates G2-M progression through control of CCNL1 ubiquitination. O'Brien S, Kelso S, Steinhart Z, Orlicky S, Mis M, Kim Y, Lin S, Sicheri F, Angers S. EMBO Rep. 2022 Dec 6;23(12):e55044. doi: 10.15252/embr.202255044. Epub 2022 Oct 24. PubMed |
| EVI1 upregulates PTGS1 (COX1) and decreases the action of tyrosine kinase inhibitors (TKIs) in chronic myeloid leukemia cells. Vinothkumar K, Chanda S, Singh VK, Biswas S, Mohapatra S, Biswas G, Chakraborty S. Int J Hematol. 2023 Jan;117(1):110-120. doi: 10.1007/s12185-022-03465-y. Epub 2022 Oct 25. PubMed |
| Pooled image-base screening of mitochondria with microraft isolation distinguishes pathogenic mitofusin 2 mutations. Yenkin AL, Bramley JC, Kremitzki CL, Waligorski JE, Liebeskind MJ, Xu XE, Chandrasekaran VD, Vakaki MA, Bachman GW, Mitra RD, Milbrandt JD, Buchser WJ. Commun Biol. 2022 Oct 25;5(1):1128. doi: 10.1038/s42003-022-04089-y. PubMed |
| SARS-CoV-2 down-regulates ACE2 through lysosomal degradation. Lu Y, Zhu Q, Fox DM, Gao C, Stanley SA, Luo K. Mol Biol Cell. 2022 Dec 1;33(14):ar147. doi: 10.1091/mbc.E22-02-0045. Epub 2022 Oct 26. PubMed |
| Dipeptide Repeat Pathology in C9orf72-ALS Is Associated with Redox, Mitochondrial and NRF2 Pathway Imbalance. Jimenez-Villegas J, Kirby J, Mata A, Cadenas S, Turner MR, Malaspina A, Shaw PJ, Cuadrado A, Rojo AI. Antioxidants (Basel). 2022 Sep 25;11(10):1897. doi: 10.3390/antiox11101897. PubMed |
| (+)-Usnic Acid and Its Derivatives as Inhibitors of a Wide Spectrum of SARS-CoV-2 Viruses. Filimonov AS, Yarovaya OI, Zaykovskaya AV, Rudometova NB, Shcherbakov DN, Chirkova VY, Baev DS, Borisevich SS, Luzina OA, Pyankov OV, Maksyutov RA, Salakhutdinov NF. Viruses. 2022 Sep 29;14(10):2154. doi: 10.3390/v14102154. PubMed |
| Nucleoplasmic lamin C rapidly accumulates at sites of nuclear envelope rupture with BAF and cGAS. Kono Y, Adam SA, Sato Y, Reddy KL, Zheng Y, Medalia O, Goldman RD, Kimura H, Shimi T. J Cell Biol. 2022 Dec 5;221(12):e202201024. doi: 10.1083/jcb.202201024. Epub 2022 Oct 27. PubMed |
| Increased CaMKK2 Expression Is an Adaptive Response That Maintains the Fitness of Tumor-Infiltrating Natural Killer Cells. Juras PK, Racioppi L, Mukherjee D, Artham S, Gao X, Akullian D'Agostino L, Chang CY, McDonnell DP. Cancer Immunol Res. 2023 Jan 3;11(1):109-122. doi: 10.1158/2326-6066.CIR-22-0391. PubMed |
| Relating individual cell division events to single-cell ERK and Akt activity time courses. Stern AD, Smith GR, Santos LC, Sarmah D, Zhang X, Lu X, Iuricich F, Pandey G, Iyengar R, Birtwistle MR. Sci Rep. 2022 Oct 27;12(1):18077. doi: 10.1038/s41598-022-23071-6. PubMed |
| Hermansky-Pudlak syndrome type 1 causes impaired anti-microbial immunity and inflammation due to dysregulated immunometabolism. Cavounidis A, Pandey S, Capitani M, Friedrich M, Cross A, Gartner L, Aschenbrenner D, Kim-Schulze S, Lam YK, Berridge G, McGovern DPB, Kessler B, Fischer R, Klenerman P, Hester J, Issa F, Torres EA, Powrie F, Gochuico BR, Gahl WA, Cohen L, Uhlig HH. Mucosal Immunol. 2022 Jun;15(6):1431-1446. doi: 10.1038/s41385-022-00572-1. Epub 2022 Oct 27. PubMed |
| Quantitative sequencing using BID-seq uncovers abundant pseudouridines in mammalian mRNA at base resolution. Dai Q, Zhang LS, Sun HL, Pajdzik K, Yang L, Ye C, Ju CW, Liu S, Wang Y, Zheng Z, Zhang L, Harada BT, Dou X, Irkliyenko I, Feng X, Zhang W, Pan T, He C. Nat Biotechnol. 2023 Mar;41(3):344-354. doi: 10.1038/s41587-022-01505-w. Epub 2022 Oct 27. PubMed |
| The AhR-SRC axis as a therapeutic vulnerability in BRAFi-resistant melanoma. Paris A, Tardif N, Baietti FM, Berra C, Leclair HM, Leucci E, Galibert MD, Corre S. EMBO Mol Med. 2022 Dec 7;14(12):e15677. doi: 10.15252/emmm.202215677. Epub 2022 Oct 28. PubMed |
| An Engineered Paper-Based 3D Coculture Model of Pancreatic Cancer to Study the Impact of Tissue Architecture and Microenvironmental Gradients on Cell Phenotype. Cadavid JL, Latour S, Nowlan F, Co IL, Landon-Brace N, Wouters BG, Grunwald BT, Nitz M, Jackson HW, McGuigan AP. Adv Healthc Mater. 2022 Oct 29:e2201846. doi: 10.1002/adhm.202201846. PubMed |
| Defining cellular complexity in human autosomal dominant polycystic kidney disease by multimodal single cell analysis. Muto Y, Dixon EE, Yoshimura Y, Wu H, Omachi K, Ledru N, Wilson PC, King AJ, Eric Olson N, Gunawan MG, Kuo JJ, Cox JH, Miner JH, Seliger SL, Woodward OM, Welling PA, Watnick TJ, Humphreys BD. Nat Commun. 2022 Oct 30;13(1):6497. doi: 10.1038/s41467-022-34255-z. PubMed |
| Different Gene Sets Are Associated With Azacitidine Response In Vitro Versus in Myelodysplastic Syndrome Patients. Le Pannerer MM, Diesch J, Casquero R, Maher M, Garcia O, Haferlach T, Zuber J, Kundgen A, Gotze KS, Buschbeck M. Hemasphere. 2022 Oct 25;6(11):e792. doi: 10.1097/HS9.0000000000000792. eCollection 2022 Nov. PubMed |
| CRISPRi screening reveals regulators of tau pathology shared between exosomal and vesicle-free tau. Polanco JC, Akimov Y, Fernandes A, Briner A, Hand GR, van Roijen M, Balistreri G, Gotz J. Life Sci Alliance. 2022 Oct 31;6(1):e202201689. doi: 10.26508/lsa.202201689. Print 2023 Jan. PubMed |
| HIV-1 Rev-RRE functional activity in primary isolates is highly dependent on minimal context-dependent changes in Rev. Dzhivhuho G, Holsey J, Honeycutt E, O'Farrell H, Rekosh D, Hammarskjold ML, Jackson PEH. Sci Rep. 2022 Nov 1;12(1):18416. doi: 10.1038/s41598-022-21714-2. PubMed |
| Monoacylglycerol O-acyltransferase 1 lowers adipocyte differentiation capacity in vitro but does not affect adiposity in mice. Singer JM, Shew TM, Ferguson D, Renkemeyer MK, Pietka TA, Hall AM, Finck BN, Lutkewitte AJ. Obesity (Silver Spring). 2022 Nov;30(11):2122-2133. doi: 10.1002/oby.23538. PubMed |
| Coupling-dependent metabolic ultradian rhythms in confluent cells. Yang S, Yamazaki S, Cox KH, Huang YL, Miller EW, Takahashi JS. Proc Natl Acad Sci U S A. 2022 Nov 8;119(45):e2211142119. doi: 10.1073/pnas.2211142119. Epub 2022 Nov 2. PubMed |
| Reactive astrocytes transduce inflammation in a blood-brain barrier model through a TNF-STAT3 signaling axis and secretion of alpha 1-antichymotrypsin. Kim H, Leng K, Park J, Sorets AG, Kim S, Shostak A, Embalabala RJ, Mlouk K, Katdare KA, Rose IVL, Sturgeon SM, Neal EH, Ao Y, Wang S, Sofroniew MV, Brunger JM, McMahon DG, Schrag MS, Kampmann M, Lippmann ES. Nat Commun. 2022 Nov 2;13(1):6581. doi: 10.1038/s41467-022-34412-4. PubMed |
| Functional E3 ligase hotspots and resistance mechanisms to small-molecule degraders. Hanzl A, Casement R, Imrichova H, Hughes SJ, Barone E, Testa A, Bauer S, Wright J, Brand M, Ciulli A, Winter GE. Nat Chem Biol. 2023 Mar;19(3):323-333. doi: 10.1038/s41589-022-01177-2. Epub 2022 Nov 3. PubMed |
| ID1 and CEBPA coordinate epidermal progenitor cell differentiation. Kantzer CG, Yang W, Grommisch D, Vikhe Patil K, Mak KH, Shirokova V, Genander M. Development. 2022 Nov 15;149(22):dev201262. doi: 10.1242/dev.201262. Epub 2022 Nov 16. PubMed |
| Selective advantage of epigenetically disrupted cancer cells via phenotypic inertia. Loukas I, Simeoni F, Milan M, Inglese P, Patel H, Goldstone R, East P, Strohbuecker S, Mitter R, Talsania B, Tang W, Ratcliffe CDH, Sahai E, Shahrezaei V, Scaffidi P. Cancer Cell. 2023 Jan 9;41(1):70-87.e14. doi: 10.1016/j.ccell.2022.10.002. Epub 2022 Nov 3. PubMed |
| BRD9-containing non-canonical BAF complex maintains somatic cell transcriptome and acts as a barrier to human reprogramming. Sevinc K, Sevinc GG, Cavga AD, Philpott M, Kelekci S, Can H, Cribbs AP, Yildiz AB, Yilmaz A, Ayar ES, Arabaci DH, Dunford JE, Ata D, Sigua LH, Qi J, Oppermann U, Onder TT. Stem Cell Reports. 2022 Dec 13;17(12):2629-2642. doi: 10.1016/j.stemcr.2022.10.005. Epub 2022 Nov 3. PubMed |
| Pathogenic variants in SLF2 and SMC5 cause segmented chromosomes and mosaic variegated hyperploidy. Grange LJ, Reynolds JJ, Ullah F, Isidor B, Shearer RF, Latypova X, Baxley RM, Oliver AW, Ganesh A, Cooke SL, Jhujh SS, McNee GS, Hollingworth R, Higgs MR, Natsume T, Khan T, Martos-Moreno GA, Chupp S, Mathew CG, Parry D, Simpson MA, Nahavandi N, Yuksel Z, Drasdo M, Kron A, Vogt P, Jonasson A, Seth SA, Gonzaga-Jauregui C, Brigatti KW, Stegmann APA, Kanemaki M, Josifova D, Uchiyama Y, Oh Y, Morimoto A, Osaka H, Ammous Z, Argente J, Matsumoto N, Stumpel CTRM, Taylor AMR, Jackson AP, Bielinsky AK, Mailand N, Le Caignec C, Davis EE, Stewart GS. Nat Commun. 2022 Nov 4;13(1):6664. doi: 10.1038/s41467-022-34349-8. PubMed |
| A genetically encoded fluorescent biosensor for detecting itaconate with subcellular resolution in living macrophages. Sun P, Zhang Z, Wang B, Liu C, Chen C, Liu P, Li X. Nat Commun. 2022 Nov 4;13(1):6562. doi: 10.1038/s41467-022-34306-5. PubMed |
| SARS-CoV-2 mitochondriopathy in COVID-19 pneumonia exacerbates hypoxemia. Archer SL, Dasgupta A, Chen KH, Wu D, Baid K, Mamatis JE, Gonzalez V, Read A, Bentley RE, Martin AY, Mewburn JD, Dunham-Snary KJ, Evans GA, Levy G, Jones O, Al-Qazazi R, Ring B, Alizadeh E, Hindmarch CC, Rossi J, Lima PD, Falzarano D, Banerjee A, Colpitts CC. Redox Biol. 2022 Dec;58:102508. doi: 10.1016/j.redox.2022.102508. Epub 2022 Oct 13. PubMed |
| Hi-TrAC reveals division of labor of transcription factors in organizing chromatin loops. Liu S, Cao Y, Cui K, Tang Q, Zhao K. Nat Commun. 2022 Nov 5;13(1):6679. doi: 10.1038/s41467-022-34276-8. PubMed |
| Hypoxia regulates CD9 expression and dissemination of B lymphoblasts. Rouger-Gaudichon J, Cousin E, Jakobczyk H, Debaize L, Rio AG, Forestier A, Arnaud MP, Villacreces A, Praloran V, Jacamo R, Galibert MD, Troadec MB, Gandemer V. Leuk Res. 2022 Dec;123:106964. doi: 10.1016/j.leukres.2022.106964. Epub 2022 Sep 28. PubMed |
| MicroRNA Content of Ewing Sarcoma Derived Extracellular Vesicles Leads to Biomarker Potential and Identification of a Previously Undocumented EWS-FLI1 Translocation. Crow J, Samuel G, Farrow E, Gibson M, Johnston J, Guest E, Miller N, Pei D, Koestler D, Pathak H, Liang X, Mangels C, Godwin AK. Biomark Insights. 2022 Oct 31;17:11772719221132693. doi: 10.1177/11772719221132693. eCollection 2022. PubMed |
| Alternative splicing downstream of EMT enhances phenotypic plasticity and malignant behavior in colon cancer. Xu T, Verhagen M, Joosten R, Sun W, Sacchetti A, Munoz Sagredo L, Orian-Rousseau V, Fodde R. Elife. 2022 Nov 8;11:e82006. doi: 10.7554/eLife.82006. PubMed |
| Membrane Sphingomyelin in Host Cells Is Essential for Nucleocapsid Penetration into the Cytoplasm after Hemifusion during Rubella Virus Entry. Mori Y, Sakata M, Sakai S, Okamoto T, Nakatsu Y, Taguwa S, Otsuki N, Maeda Y, Hanada K, Matsuura Y, Takeda M. mBio. 2022 Dec 20;13(6):e0169822. doi: 10.1128/mbio.01698-22. Epub 2022 Nov 8. PubMed |
| Systematic discovery and functional dissection of enhancers needed for cancer cell fitness and proliferation. Chen PB, Fiaux PC, Zhang K, Li B, Kubo N, Jiang S, Hu R, Rooholfada E, Wu S, Wang M, Wang W, McVicker G, Mischel PS, Ren B. Cell Rep. 2022 Nov 8;41(6):111630. doi: 10.1016/j.celrep.2022.111630. PubMed |
| MsrB1-regulated GAPDH oxidation plays programmatic roles in shaping metabolic and inflammatory signatures during macrophage activation. Yoo HJ, Choi DW, Roh YJ, Lee YM, Lim JH, Eo S, Lee HJ, Kim NY, Kim S, Cho S, Im G, Lee BC, Kim JH. Cell Rep. 2022 Nov 8;41(6):111598. doi: 10.1016/j.celrep.2022.111598. PubMed |
| Bortezomib inhibits ZIKV/DENV by interfering with viral polyprotein cleavage via the ERAD pathway. Ci Y, Yao B, Yue K, Yang Y, Xu C, Li DF, Qin CF, Shi L. Cell Chem Biol. 2022 Oct 19:S2451-9456(22)00357-9. doi: 10.1016/j.chembiol.2022.10.003. PubMed |
| Parthenolide and arsenic trioxide co-trigger autophagy-accompanied apoptosis in hepatocellular carcinoma cells. Yi J, Gong X, Yin XY, Wang L, Hou JX, Chen J, Xie B, Chen G, Wang LN, Wang XY, Wang DC, Wei HL. Front Oncol. 2022 Oct 24;12:988528. doi: 10.3389/fonc.2022.988528. eCollection 2022. PubMed |
| Characteristics and Resistance to Cisplatin of Human Neuroblastoma Cells Co-Cultivated with Immune and Stromal Cells. Kitaeva KV, Chulpanova DS, Zhuravleva MN, Filin IY, Deviatiiarov RM, Ballard-Reisch AC, Rizvanov AA, Solovyeva VV. Bioengineering (Basel). 2022 Nov 5;9(11):655. doi: 10.3390/bioengineering9110655. PubMed |
| Novel protein complexes containing autophagy and UPS components regulate proteasome-dependent PARK2 recruitment onto mitochondria and PARK2-PARK6 activity during mitophagy. Kocaturk NM, Peker N, Eberhart K, Akkoc Y, Deveci G, Dengjel J, Gozuacik D. Cell Death Dis. 2022 Nov 10;13(11):947. doi: 10.1038/s41419-022-05339-x. PubMed |
| Divergent SARS-CoV-2 variant emerges in white-tailed deer with deer-to-human transmission. Pickering B, Lung O, Maguire F, Kruczkiewicz P, Kotwa JD, Buchanan T, Gagnier M, Guthrie JL, Jardine CM, Marchand-Austin A, Masse A, McClinchey H, Nirmalarajah K, Aftanas P, Blais-Savoie J, Chee HY, Chien E, Yim W, Banete A, Griffin BD, Yip L, Goolia M, Suderman M, Pinette M, Smith G, Sullivan D, Rudar J, Vernygora O, Adey E, Nebroski M, Goyette G, Finzi A, Laroche G, Ariana A, Vahkal B, Cote M, McGeer AJ, Nituch L, Mubareka S, Bowman J. Nat Microbiol. 2022 Dec;7(12):2011-2024. doi: 10.1038/s41564-022-01268-9. Epub 2022 Nov 10. PubMed |
| AMPK-dependent phosphorylation of MTFR1L regulates mitochondrial morphology. Tilokani L, Russell FM, Hamilton S, Virga DM, Segawa M, Paupe V, Gruszczyk AV, Protasoni M, Tabara LC, Johnson M, Anand H, Murphy MP, Hardie DG, Polleux F, Prudent J. Sci Adv. 2022 Nov 11;8(45):eabo7956. doi: 10.1126/sciadv.abo7956. Epub 2022 Nov 11. PubMed |
| Frataxin deficiency alters gene expression in Friedreich ataxia derived IPSC-neurons and cardiomyocytes. Angulo MB, Bertalovitz A, Argenziano MA, Yang J, Patel A, Zesiewicz T, McDonald TV. Mol Genet Genomic Med. 2023 Jan;11(1):e2093. doi: 10.1002/mgg3.2093. Epub 2022 Nov 11. PubMed |
| Repression of the PRELP gene is relieved by histone deacetylase inhibitors through acetylation of histone H2B lysine 5 in bladder cancer. Shozu K, Kaneko S, Shinkai N, Dozen A, Kosuge H, Nakakido M, Machino H, Takasawa K, Asada K, Komatsu M, Tsumoto K, Ohnuma SI, Hamamoto R. Clin Epigenetics. 2022 Nov 12;14(1):147. doi: 10.1186/s13148-022-01370-z. PubMed |
| Elucidation of the Role of FAM210B in Mitochondrial Metabolism and Erythropoiesis. Suzuki C, Fujiwara T, Shima H, Ono K, Saito K, Kato H, Onodera K, Ichikawa S, Fukuhara N, Onishi Y, Yokoyama H, Nakamura Y, Igarashi K, Harigae H. Mol Cell Biol. 2022 Dec 15;42(12):e0014322. doi: 10.1128/mcb.00143-22. Epub 2022 Nov 14. PubMed |
| SMA-linked SMN mutants prevent phase separation properties and SMN interactions with FMRP family members. Binda O, Juillard F, Ducassou JN, Kleijwegt C, Paris G, Didillon A, Baklouti F, Corpet A, Coute Y, Cote J, Lomonte P. Life Sci Alliance. 2022 Nov 14;6(1):e202201429. doi: 10.26508/lsa.202201429. Print 2023 Jan. PubMed |
| Single-cell transcriptomics defines an improved, validated monoculture protocol for differentiation of human iPSC to microglia. Washer SJ, Perez-Alcantara M, Chen Y, Steer J, James WS, Trynka G, Bassett AR, Cowley SA. Sci Rep. 2022 Nov 14;12(1):19454. doi: 10.1038/s41598-022-23477-2. PubMed |
| Na(+)/H(+)-exchanger 1 enhances antitumor activity of engineered NK-92 natural killer cells. Gong YY, Shao H, Li Y, Brafford P, Stine ZE, Sun J, Felsher DW, Orange JS, Albelda SM, Dang CV. Cancer Res Commun. 2022 Aug;2(8):842-856. doi: 10.1158/2767-9764.crc-22-0270. Epub 2022 Aug 22. PubMed |
| Bcl-xL inhibition radiosensitizes PIK3CA/PTEN wild-type triple negative breast cancers with low Mcl-1 expression. Pesch AM, Chandler BC, Michmerhuizen AR, Carter HM, Hirsh NH, Wilder-Romans K, Liu M, Ward T, Ritter CL, Nino CA, Jungles KM, Pierce LJ, Rae JM, Speers CW. Cancer Res Commun. 2022 Jul;2(7):679-693. doi: 10.1158/2767-9764.crc-22-0024. Epub 2022 Jul 20. PubMed |
| SARS-CoV-2 variant Alpha has a spike-dependent replication advantage over the ancestral B.1 strain in human cells with low ACE2 expression. Niemeyer D, Stenzel S, Veith T, Schroeder S, Friedmann K, Weege F, Trimpert J, Heinze J, Richter A, Jansen J, Emanuel J, Kazmierski J, Pott F, Jeworowski LM, Olmer R, Jaboreck MC, Tenner B, Papies J, Walper F, Schmidt ML, Heinemann N, Moncke-Buchner E, Baumgardt M, Hoffmann K, Widera M, Thao TTN, Balazs A, Schulze J, Mache C, Jones TC, Morkel M, Ciesek S, Hanitsch LG, Mall MA, Hocke AC, Thiel V, Osterrieder K, Wolff T, Martin U, Corman VM, Muller MA, Goffinet C, Drosten C. PLoS Biol. 2022 Nov 16;20(11):e3001871. doi: 10.1371/journal.pbio.3001871. eCollection 2022 Nov. PubMed |
| Elective nodal irradiation mitigates local and systemic immunity generated by combination radiation and immunotherapy in head and neck tumors. Darragh LB, Gadwa J, Pham TT, Van Court B, Neupert B, Olimpo NA, Nguyen K, Nguyen D, Knitz MW, Hoen M, Corbo S, Joshi M, Zhuang Y, Amann M, Wang XJ, Dow S, Kedl RM, Samedi V, Boss MK, Karam SD. Nat Commun. 2022 Nov 16;13(1):7015. doi: 10.1038/s41467-022-34676-w. PubMed |
| Colon tumour cell death causes mTOR dependence by paracrine P2X4 stimulation. Schmitt M, Ceteci F, Gupta J, Pesic M, Bottger TW, Nicolas AM, Kennel KB, Engel E, Schewe M, Callak Kirisozu A, Petrocelli V, Dabiri Y, Varga J, Ramakrishnan M, Karimova M, Ablasser A, Sato T, Arkan MC, de Sauvage FJ, Greten FR. Nature. 2022 Dec;612(7939):347-353. doi: 10.1038/s41586-022-05426-1. Epub 2022 Nov 16. PubMed |
| Reciprocal effects of mTOR inhibitors on pro-survival proteins dictate therapeutic responses in tuberous sclerosis complex. McNamara MC, Hosios AM, Torrence ME, Zhao T, Fraser C, Wilkinson M, Kwiatkowski DJ, Henske EP, Wu CL, Sarosiek KA, Valvezan AJ, Manning BD. iScience. 2022 Oct 28;25(11):105458. doi: 10.1016/j.isci.2022.105458. eCollection 2022 Nov 18. PubMed |
| Dual-fluorescent reporter for live-cell imaging of the ER during DENV infection. Corliss L, Holliday M, Lennemann NJ. Front Cell Infect Microbiol. 2022 Oct 25;12:1042735. doi: 10.3389/fcimb.2022.1042735. eCollection 2022. PubMed |
| A feasibility study of different commercially available serum-free mediums to enhance lentivirus and adeno-associated virus production in HEK 293 suspension cells. Celebi Torabfam G, Yetisgin AA, Erdem C, Cayli A, Kutlu O, Cetinel S. Cytotechnology. 2022 Dec;74(6):635-655. doi: 10.1007/s10616-022-00551-1. Epub 2022 Oct 25. PubMed |
| Cooperative binding of T cell receptor and CD4 to peptide-MHC enhances antigen sensitivity. Rushdi MN, Pan V, Li K, Choi HK, Travaglino S, Hong J, Griffitts F, Agnihotri P, Mariuzza RA, Ke Y, Zhu C. Nat Commun. 2022 Nov 17;13(1):7055. doi: 10.1038/s41467-022-34587-w. PubMed |
| Cancer cell survival depends on collagen uptake into tumor-associated stroma. Hsu KS, Dunleavey JM, Szot C, Yang L, Hilton MB, Morris K, Seaman S, Feng Y, Lutz EM, Koogle R, Tomassoni-Ardori F, Saha S, Zhang XM, Zudaire E, Bajgain P, Rose J, Zhu Z, Dimitrov DS, Cuttitta F, Emenaker NJ, Tessarollo L, St Croix B. Nat Commun. 2022 Nov 18;13(1):7078. doi: 10.1038/s41467-022-34643-5. PubMed |
| Selection of red fluorescent protein for genetic labeling of mitochondria and intercellular transfer of viable mitochondria. Taiko I, Takano C, Nomoto M, Hayashida S, Kanemaru K, Miki T. Sci Rep. 2022 Nov 18;12(1):19841. doi: 10.1038/s41598-022-24297-0. PubMed |
| Complementary anti-cancer pathways triggered by inhibition of sideroflexin 4 in ovarian cancer. Tesfay L, Paul BT, Hegde P, Brewer M, Habbani S, Jellison E, Moore T, Wu H, Torti SV, Torti FM. Sci Rep. 2022 Nov 19;12(1):19936. doi: 10.1038/s41598-022-24391-3. PubMed |
| Tissue factor-induced fibrinogenesis mediates cancer cell clustering and multiclonal peritoneal metastasis. Miyazaki M, Nakabo A, Nagano Y, Nagamura Y, Yanagihara K, Ohki R, Nakamura Y, Fukami K, Kawamoto J, Umayahara K, Sakamoto M, Iwaya K, Yamaguchi H. Cancer Lett. 2023 Jan 28;553:215983. doi: 10.1016/j.canlet.2022.215983. Epub 2022 Oct 28. PubMed |
| Identification of novel F508del-CFTR traffic correctors among triazole derivatives. Bacalhau M, Ferreira FC, Kmit A, Souza FR, da Silva VD, Pimentel AS, Amaral MD, Buarque CD, Lopes-Pacheco M. Eur J Pharmacol. 2023 Jan 5;938:175396. doi: 10.1016/j.ejphar.2022.175396. Epub 2022 Nov 19. PubMed |
| VpdC is a ubiquitin-activated phospholipase effector that regulates Legionella vacuole expansion during infection. Li X, Anderson DE, Chang YY, Jarnik M, Machner MP. Proc Natl Acad Sci U S A. 2022 Nov 29;119(48):e2209149119. doi: 10.1073/pnas.2209149119. Epub 2022 Nov 21. PubMed |
| Integration of 3D genome topology and local chromatin features uncovers enhancers underlying craniofacial-specific cartilage defects. Chen Q, Dai J, Bian Q. Sci Adv. 2022 Nov 25;8(47):eabo3648. doi: 10.1126/sciadv.abo3648. Epub 2022 Nov 23. PubMed |
| Microscopy-based phenotypic profiling of infection by Staphylococcus aureus clinical isolates reveals intracellular lifestyle as a prevalent feature. Rodrigues Lopes I, Alcantara LM, Silva RJ, Josse J, Vega EP, Cabrerizo AM, Bonhomme M, Lopez D, Laurent F, Vandenesch F, Mano M, Eulalio A. Nat Commun. 2022 Nov 22;13(1):7174. doi: 10.1038/s41467-022-34790-9. PubMed |
| MEK inhibitor resistance in lung adenocarcinoma is associated with addiction to sustained ERK suppression. Farnsworth DA, Inoue Y, Johnson FD, de Rappard-Yuswack G, Lu D, Shi R, Ma LIJ, Mattar MS, Somwar R, Ladanyi M, Unni AM, Lockwood WW. NPJ Precis Oncol. 2022 Nov 23;6(1):88. doi: 10.1038/s41698-022-00328-x. PubMed |
| Mitochondrial Factor C20orf7 Facilitates the EMT-Mediated Cancer Cell Migration and the Proliferation of Colon Cancer In Vitro and In Vivo. Liu HH, Lee CH, Hsieh YC, Zheng JH, Liu YR, Chang CH, Cho EC. Genes (Basel). 2022 Nov 14;13(11):2111. doi: 10.3390/genes13112111. PubMed |
| Nanobody derived using a peptide epitope from the spike protein receptor-binding motif inhibits entry of SARS-CoV-2 variants. Mendon N, Ganie RA, Kesarwani S, Dileep D, Sasi S, Lama P, Chandra A, Sirajuddin M. J Biol Chem. 2023 Jan;299(1):102732. doi: 10.1016/j.jbc.2022.102732. Epub 2022 Nov 22. PubMed |
| UCHL5 Promotes Proliferation and Migration of Bladder Cancer Cells by Activating c-Myc via AKT/mTOR Signaling. Cao Y, Yan X, Bai X, Tang F, Si P, Bai C, Tuoheti K, Guo L, Yisha Z, Liu T, Liu T. Cancers (Basel). 2022 Nov 10;14(22):5538. doi: 10.3390/cancers14225538. PubMed |
| Girdin Promotes Tumorigenesis and Chemoresistance in Lung Adenocarcinoma by Interacting with PKM2. Cao F, Yang D, Tang F, Lu C, He X, Chen S, Yang Z, Gong S, Sun L, Enomoto A, Takahashi M, Weng L. Cancers (Basel). 2022 Nov 19;14(22):5688. doi: 10.3390/cancers14225688. PubMed |
| LPS-Induced Inhibition of miR-143 Expression in Brown Adipocytes Promotes Thermogenesis and Fever. Liu J, Zeng D, Luo J, Wang H, Xiong J, Chen X, Chen T, Sun J, Xi Q, Zhang Y. Int J Mol Sci. 2022 Nov 9;23(22):13805. doi: 10.3390/ijms232213805. PubMed |
| Decoding molecular programs in melanoma brain metastases. Radke J, Schumann E, Onken J, Koll R, Acker G, Bodnar B, Senger C, Tierling S, Mobs M, Vajkoczy P, Vidal A, Hogler S, Kodajova P, Westphal D, Meier F, Heppner F, Kreuzer-Redmer S, Grebien F, Jurchott K, Redmer T. Nat Commun. 2022 Nov 26;13(1):7304. doi: 10.1038/s41467-022-34899-x. PubMed |
| Activation of orphan receptor GPR132 induces cell differentiation in acute myeloid leukemia. Yi C, He J, Huang D, Zhao Y, Zhang C, Ye X, Huang Y, Nussinov R, Zheng J, Liu M, Lu W. Cell Death Dis. 2022 Nov 27;13(11):1004. doi: 10.1038/s41419-022-05434-z. PubMed |
| The BRD4 Inhibitor dBET57 Exerts Anticancer Effects by Targeting Superenhancer-Related Genes in Neuroblastoma. Jia SQ, Zhuo R, Zhang ZM, Yang Y, Tao YF, Wang JW, Li XL, Xie Y, Li G, Wu D, Chen YL, Yu JJ, Feng CX, Li ZH, Zhou RF, Yang RD, Yang PC, Zhou B, Wan XM, Wu YM, Jiao WY, Zhou NN, Fang F, Pan J. J Immunol Res. 2022 Nov 16;2022:7945884. doi: 10.1155/2022/7945884. eCollection 2022. PubMed |
| mRNA 5' terminal sequences drive 200-fold differences in expression through effects on synthesis, translation and decay. van den Elzen AMG, Watson MJ, Thoreen CC. PLoS Genet. 2022 Nov 28;18(11):e1010532. doi: 10.1371/journal.pgen.1010532. eCollection 2022 Nov. PubMed |
| Loss of Gap Junction Factor Connexin 43 Results in an Increase of Exosomal Tetraspanins in Human Lung Cancer Cell Line A549. Fleck AP, Flotte AB, Si EP, Mu D. MicroPubl Biol. 2022 Nov 13;2022:10.17912/micropub.biology.000683. doi: 10.17912/micropub.biology.000683. eCollection 2022. PubMed |
| Bridged Proteolysis Targeting Chimera (PROTAC) Enables Degradation of Undruggable Targets. Xiong Y, Zhong Y, Yim H, Yang X, Park KS, Xie L, Poulikakos PI, Han X, Xiong Y, Chen X, Liu J, Jin J. J Am Chem Soc. 2022 Dec 14;144(49):22622-22632. doi: 10.1021/jacs.2c09255. Epub 2022 Nov 30. PubMed |
| SETD1A regulates transcriptional pause release of heme biosynthesis genes in leukemia. Hoshii T, Perlee S, Kikuchi S, Rahmutulla B, Fukuyo M, Masuda T, Ohtsuki S, Soga T, Nabet B, Kaneda A. Cell Rep. 2022 Nov 29;41(9):111727. doi: 10.1016/j.celrep.2022.111727. PubMed |
| Extensive androgen receptor enhancer heterogeneity in primary prostate cancers underlies transcriptional diversity and metastatic potential. Kneppers J, Severson TM, Siefert JC, Schol P, Joosten SEP, Yu IPL, Huang CF, Morova T, Altintas UB, Giambartolomei C, Seo JH, Baca SC, Carneiro I, Emberly E, Pasaniuc B, Jeronimo C, Henrique R, Freedman ML, Wessels LFA, Lack NA, Bergman AM, Zwart W. Nat Commun. 2022 Nov 30;13(1):7367. doi: 10.1038/s41467-022-35135-2. PubMed |
| IMPDH inhibition activates TLR-VCAM1 pathway and suppresses the development of MLL-fusion leukemia. Liu X, Sato N, Yabushita T, Li J, Jia Y, Tamura M, Asada S, Fujino T, Fukushima T, Yonezawa T, Tanaka Y, Fukuyama T, Tsuchiya A, Shikata S, Iwamura H, Kinouchi C, Komatsu K, Yamasaki S, Shibata T, Sasaki AT, Schibler J, Wunderlich M, O'Brien E, Mizukawa B, Mulloy JC, Sugiura Y, Takizawa H, Shibata T, Miyake K, Kitamura T, Goyama S. EMBO Mol Med. 2023 Jan 11;15(1):e15631. doi: 10.15252/emmm.202115631. Epub 2022 Dec 1. PubMed |
| The PNUTS-PP1 complex acts as an intrinsic barrier to herpesvirus KSHV gene expression and replication. Devlin AM, Shukla A, Ruiz JC, Barnes SD, Govindan A, Hunter OV, Scarborough AM, D'Orso I, Conrad NK. Nat Commun. 2022 Dec 2;13(1):7447. doi: 10.1038/s41467-022-35268-4. PubMed |
| SERPINB9 is commonly amplified and high expression in cancer cells correlates with poor immune checkpoint blockade response. Ibanez-Molero S, van Vliet A, Pozniak J, Hummelink K, Terry AM, Monkhorst K, Sanders J, Hofland I, Landeloos E, Van Herck Y, Bechter O, Kuilman T, Zhong W, Marine JC, Wessels L, Peeper DS. Oncoimmunology. 2022 Nov 29;11(1):2139074. doi: 10.1080/2162402X.2022.2139074. eCollection 2022. PubMed |
| Autophagy inhibition signals through senescence to promote tumor suppression. Peng N, Kang HH, Feng Y, Minikes AM, Jiang X. Autophagy. 2022 Dec 15:1-17. doi: 10.1080/15548627.2022.2155794. PubMed |
| Genome-wide gain-of-function screening characterized lncRNA regulators for tumor immune response. Wang Y, Zhao Y, Guo W, Yadav GS, Bhaskarla C, Wang Z, Wang X, Li S, Wang Y, Chen Y, Pattarayan D, Xie W, Li S, Lu B, Kammula US, Zhang M, Yang D. Sci Adv. 2022 Dec 9;8(49):eadd0005. doi: 10.1126/sciadv.add0005. Epub 2022 Dec 7. PubMed |
| Hypoxic activation of PFKFB4 in breast tumor microenvironment shapes metabolic and cellular plasticity to accentuate metastatic competence. Dai T, Rosario SR, Katsuta E, Sawant Dessai A, Paterson EJ, Novickis AT, Cortes Gomez E, Zhu B, Liu S, Wang H, Abrams SI, Seshadri M, Bshara W, Dasgupta S. Cell Rep. 2022 Dec 6;41(10):111756. doi: 10.1016/j.celrep.2022.111756. PubMed |
| Close relatives of MERS-CoV in bats use ACE2 as their functional receptors. Xiong Q, Cao L, Ma C, Tortorici MA, Liu C, Si J, Liu P, Gu M, Walls AC, Wang C, Shi L, Tong F, Huang M, Li J, Zhao C, Shen C, Chen Y, Zhao H, Lan K, Corti D, Veesler D, Wang X, Yan H. Nature. 2022 Dec;612(7941):748-757. doi: 10.1038/s41586-022-05513-3. Epub 2022 Dec 7. PubMed |
| Extracellular Galectin 4 Drives Immune Evasion and Promotes T-cell Apoptosis in Pancreatic Cancer. Lidstrom T, Cumming J, Gaur R, Frangsmyr L, Pateras IS, Mickert MJ, Franklin O, Forsell MNE, Arnberg N, Dongre M, Patthey C, Ohlund D. Cancer Immunol Res. 2023 Jan 3;11(1):72-92. doi: 10.1158/2326-6066.CIR-21-1088. PubMed |
| Arginine-rich C9ORF72 ALS proteins stall ribosomes in a manner distinct from a canonical ribosome-associated quality control substrate. Kriachkov V, Ormsby AR, Kusnadi EP, McWilliam HEG, Mintern JD, Amarasinghe SL, Ritchie ME, Furic L, Hatters DM. J Biol Chem. 2023 Jan;299(1):102774. doi: 10.1016/j.jbc.2022.102774. Epub 2022 Dec 5. PubMed |
| RUNX1 isoform disequilibrium promotes the development of trisomy 21-associated myeloid leukemia. Gialesaki S, Brauer-Hartmann D, Issa H, Bhayadia R, Alejo-Valle O, Verboon L, Schmell AL, Laszig S, Regenyi E, Schuschel K, Labuhn M, Ng M, Winkler R, Ihling C, Sinz A, Glass M, Huttelmaier S, Matzk S, Schmid L, Struwe FJ, Kadel SK, Reinhardt D, Yaspo ML, Heckl D, Klusmann JH. Blood. 2023 Mar 9;141(10):1105-1118. doi: 10.1182/blood.2022017619. PubMed |
| Stress-induced reversible cell-cycle arrest requires PRC2/PRC1-mediated control of mitophagy in Drosophila germline stem cells and human iPSCs. Taslim TH, Hussein AM, Keshri R, Ishibashi JR, Chan TC, Nguyen BN, Liu S, Brewer D, Harper S, Lyons S, Garver B, Dang J, Balachandar N, Jhajharia S, Castillo DD, Mathieu J, Ruohola-Baker H. Stem Cell Reports. 2023 Jan 10;18(1):269-288. doi: 10.1016/j.stemcr.2022.11.004. Epub 2022 Dec 8. PubMed |
| Bulk IgG glycosylation predicts COVID-19 severity and vaccine antibody response. Ash MK, Bhimalli PP, Cho BK, Mattamana BB, Gambut S, Tarhoni I, Fhied CL, Reyes AF, Welninski SJ, Arivalagan J, Negrao F, Goel R, Beck TL, Hope TJ, Sha BE, Goo YA, Al-Harthi L, Mamede JI, Borgia JA, Kelleher NL, Schneider JR. Cell Rep. 2022 Dec 13;41(11):111799. doi: 10.1016/j.celrep.2022.111799. Epub 2022 Nov 22. PubMed |
| Discovery of a small molecule ligand of FRS2 that inhibits invasion and tumor growth. Santhana Kumar K, Brunner C, Schuster M, Kopp LL, Gries A, Yan S, Jurt S, Moehle K, Bruns D, Grotzer M, Zerbe O, Schneider G, Baumgartner M. Cell Oncol (Dordr). 2023 Apr;46(2):331-356. doi: 10.1007/s13402-022-00753-x. Epub 2022 Dec 10. PubMed |
| CRL2(ZER1/ZYG11B) recognizes small N-terminal residues for degradation. Li Y, Zhao Y, Yan X, Ye C, Weirich S, Zhang B, Wang X, Song L, Jiang C, Jeltsch A, Dong C, Mi W. Nat Commun. 2022 Dec 10;13(1):7636. doi: 10.1038/s41467-022-35169-6. PubMed |
| The STIM1/2-Regulated Calcium Homeostasis Is Impaired in Hippocampal Neurons of the 5xFAD Mouse Model of Alzheimer's Disease. Skobeleva K, Shalygin A, Mikhaylova E, Guzhova I, Ryazantseva M, Kaznacheyeva E. Int J Mol Sci. 2022 Nov 26;23(23):14810. doi: 10.3390/ijms232314810. PubMed |
| Multi-Omics Immune Interaction Networks in Lung Cancer Tumorigenesis, Proliferation, and Survival. Ye Q, Hickey J, Summers K, Falatovich B, Gencheva M, Eubank TD, Ivanov AV, Guo NL. Int J Mol Sci. 2022 Nov 29;23(23):14978. doi: 10.3390/ijms232314978. PubMed |
| An Optogenetic-Controlled Cell Reprogramming System for Driving Cell Fate and Light-Responsive Chimeric Mice. Wang M, Liu Y, Wang Z, Qiao L, Ma X, Hu L, Kong D, Wang Y, Ye H. Adv Sci (Weinh). 2023 Feb;10(4):e2202858. doi: 10.1002/advs.202202858. Epub 2022 Dec 11. PubMed |
| Idarubicin combats abiraterone and enzalutamide resistance in prostate cells via targeting XPA protein. Zhang Y, Wei W, Li C, Yan S, Wang S, Xiao S, He C, Li J, Qi Z, Li B, Yang K, Li C. Cell Death Dis. 2022 Dec 12;13(12):1034. doi: 10.1038/s41419-022-05490-5. PubMed |
| An RNA-targeting CRISPR-Cas13d system alleviates disease-related phenotypes in Huntington's disease models. Morelli KH, Wu Q, Gosztyla ML, Liu H, Yao M, Zhang C, Chen J, Marina RJ, Lee K, Jones KL, Huang MY, Li A, Smith-Geater C, Thompson LM, Duan W, Yeo GW. Nat Neurosci. 2023 Jan;26(1):27-38. doi: 10.1038/s41593-022-01207-1. Epub 2022 Dec 12. PubMed |
| HNF1B-driven three-dimensional chromatin structure for molecular classification in pancreatic cancers. Kato H, Tateishi K, Iwadate D, Yamamoto K, Fujiwara H, Nakatsuka T, Kudo Y, Hayakawa Y, Ijichi H, Otsuka M, Kishikawa T, Takahashi R, Miyabayashi K, Nakai Y, Hirata Y, Toyoda A, Morishita S, Fujishiro M. Cancer Sci. 2023 Apr;114(4):1672-1685. doi: 10.1111/cas.15690. Epub 2022 Dec 25. PubMed |
| A COL4A4-G394S Variant and Impaired Collagen IV Trimerization in a Patient with Mild Alport Syndrome. Kohler J, Omachi K, Charu V, Miner JH, Bhalla V. Kidney360. 2022 Oct 26;3(11):1899-1908. doi: 10.34067/KID.0005472022. eCollection 2022 Nov 24. PubMed |
Macrophage NFATC2 mediates angiogenic signaling during mycobacterial infection.
Brewer WJ, Xet-Mull AM, Yu A, Sweeney MI, Walton EM, Tobin DM.
Cell Rep. 2022 Dec 13;41(11):111817. doi: 10.1016/j.celrep.2022.111817.
PubMed
Associated Plasmids |
| Opa1 and Drp1 reciprocally regulate cristae morphology, ETC function, and NAD(+) regeneration in KRas-mutant lung adenocarcinoma. Sessions DT, Kim KB, Kashatus JA, Churchill N, Park KS, Mayo MW, Sesaki H, Kashatus DF. Cell Rep. 2022 Dec 13;41(11):111818. doi: 10.1016/j.celrep.2022.111818. PubMed |
Engineered cell entry links receptor biology with single-cell genomics.
Yu B, Shi Q, Belk JA, Yost KE, Parker KR, Li R, Liu BB, Huang H, Lingwood D, Greenleaf WJ, Davis MM, Satpathy AT, Chang HY.
Cell. 2022 Dec 22;185(26):4904-4920.e22. doi: 10.1016/j.cell.2022.11.016. Epub 2022 Dec 13.
PubMed
Associated Plasmids |
| Single-cell CRISPR immune screens reveal immunological roles of tumor intrinsic factors. Hou J, Liang S, Xu C, Wei Y, Wang Y, Tan Y, Sahni N, McGrail DJ, Bernatchez C, Davies M, Li Y, Chen R, Yi SS, Chen Y, Yee C, Chen K, Peng W. NAR Cancer. 2022 Dec 9;4(4):zcac038. doi: 10.1093/narcan/zcac038. eCollection 2022 Dec. PubMed |
| HNF1B Alters an Evolutionarily Conserved Nephrogenic Program of Target Genes. Grand K, Stoltz M, Rizzo L, Rock R, Kaminski MM, Salinas G, Getwan M, Naert T, Pichler R, Lienkamp SS. J Am Soc Nephrol. 2023 Mar 1;34(3):412-432. doi: 10.1681/ASN.2022010076. Epub 2022 Dec 15. PubMed |
| KMT2D deficiency drives lung squamous cell carcinoma and hypersensitivity to RTK-RAS inhibition. Pan Y, Han H, Hu H, Wang H, Song Y, Hao Y, Tong X, Patel AS, Misirlioglu S, Tang S, Huang HY, Geng K, Chen T, Karatza A, Sherman F, Labbe KE, Yang F, Chafitz A, Peng C, Guo C, Moreira AL, Velcheti V, Lau SCM, Sui P, Chen H, Diehl JA, Rustgi AK, Bass AJ, Poirier JT, Zhang X, Ji H, Zhang H, Wong KK. Cancer Cell. 2023 Jan 9;41(1):88-105.e8. doi: 10.1016/j.ccell.2022.11.015. Epub 2022 Dec 15. PubMed |
| Nsp1 proteins of human coronaviruses HCoV-OC43 and SARS-CoV2 inhibit stress granule formation. Dolliver SM, Kleer M, Bui-Marinos MP, Ying S, Corcoran JA, Khaperskyy DA. PLoS Pathog. 2022 Dec 19;18(12):e1011041. doi: 10.1371/journal.ppat.1011041. eCollection 2022 Dec. PubMed |
| NCK1 Modulates Neuronal Actin Dynamics and Promotes Dendritic Spine, Synapse, and Memory Formation. Diab AM, Wigerius M, Quinn DP, Qi J, Shahin I, Paffile J, Krueger K, Karten B, Krueger SR, Fawcett JP. J Neurosci. 2023 Feb 8;43(6):885-901. doi: 10.1523/JNEUROSCI.0495-21.2022. Epub 2022 Dec 19. PubMed |
| mTORC1 regulates a lysosome-dependent adaptive shift in intracellular lipid species. Hosios AM, Wilkinson ME, McNamara MC, Kalafut KC, Torrence ME, Asara JM, Manning BD. Nat Metab. 2022 Dec;4(12):1792-1811. doi: 10.1038/s42255-022-00706-6. Epub 2022 Dec 19. PubMed |
| Alternative splicing liberates a cryptic cytoplasmic isoform of mitochondrial MECR that antagonizes influenza virus. Baker SF, Meistermann H, Tzouros M, Baker A, Golling S, Polster JS, Ledwith MP, Gitter A, Augustin A, Javanbakht H, Mehle A. PLoS Biol. 2022 Dec 21;20(12):e3001934. doi: 10.1371/journal.pbio.3001934. eCollection 2022 Dec. PubMed |
| A genome-wide CRISPR screen identifies CALCOCO2 as a regulator of beta cell function influencing type 2 diabetes risk. Rottner AK, Ye Y, Navarro-Guerrero E, Rajesh V, Pollner A, Bevacqua RJ, Yang J, Spigelman AF, Baronio R, Bautista A, Thomsen SK, Lyon J, Nawaz S, Smith N, Wesolowska-Andersen A, Fox JEM, Sun H, Kim SK, Ebner D, MacDonald PE, Gloyn AL. Nat Genet. 2023 Jan;55(1):54-65. doi: 10.1038/s41588-022-01261-2. Epub 2022 Dec 21. PubMed |
| BRD8 maintains glioblastoma by epigenetic reprogramming of the p53 network. Sun X, Klingbeil O, Lu B, Wu C, Ballon C, Ouyang M, Wu XS, Jin Y, Hwangbo Y, Huang YH, Somerville TDD, Chang K, Park J, Chung T, Lyons SK, Shi J, Vogel H, Schulder M, Vakoc CR, Mills AA. Nature. 2023 Jan;613(7942):195-202. doi: 10.1038/s41586-022-05551-x. Epub 2022 Dec 21. PubMed |
| Ubiquitin variants potently inhibit SARS-CoV-2 PLpro and viral replication via a novel site distal to the protease active site. van Vliet VJE, Huynh N, Pala J, Patel A, Singer A, Slater C, Chung J, van Huizen M, Teyra J, Miersch S, Luu GK, Ye W, Sharma N, Ganaie SS, Russell R, Chen C, Maynard M, Amarasinghe GK, Mark BL, Kikkert M, Sidhu SS. PLoS Pathog. 2022 Dec 22;18(12):e1011065. doi: 10.1371/journal.ppat.1011065. eCollection 2022 Dec. PubMed |
| A conformation-specific nanobody targeting the nicotinamide mononucleotide-activated state of SARM1. Hou YN, Cai Y, Li WH, He WM, Zhao ZY, Zhu WJ, Wang Q, Mai X, Liu J, Lee HC, Stjepanovic G, Zhang H, Zhao YJ. Nat Commun. 2022 Dec 22;13(1):7898. doi: 10.1038/s41467-022-35581-y. PubMed |
| ACTR5 controls CDKN2A and tumor progression in an INO80-independent manner. Xu X, Chan AKN, Li M, Liu Q, Mattson N, Pangeni Pokharel S, Chang WH, Yuan YC, Wang J, Moore RE, Pirrotte P, Wu J, Su R, Muschen M, Rosen ST, Chen J, Yang L, Chen CW. Sci Adv. 2022 Dec 23;8(51):eadc8911. doi: 10.1126/sciadv.adc8911. Epub 2022 Dec 23. PubMed |
| Immune checkpoint therapy-elicited sialylation of IgG antibodies impairs antitumorigenic type I interferon responses in hepatocellular carcinoma. Wu RQ, Lao XM, Chen DP, Qin H, Mu M, Cao WJ, Deng J, Wan CC, Zhan WY, Wang JC, Xu L, Chen MS, Gao Q, Zheng L, Wei Y, Kuang DM. Immunity. 2023 Jan 10;56(1):180-192.e11. doi: 10.1016/j.immuni.2022.11.014. Epub 2022 Dec 22. PubMed |
A Ubiquitination Cascade Regulating the Integrated Stress Response and Survival in Carcinomas.
Cervia LD, Shibue T, Borah AA, Gaeta B, He L, Leung L, Li N, Moyer SM, Shim BH, Dumont N, Gonzalez A, Bick NR, Kazachkova M, Dempster JM, Krill-Burger JM, Piccioni F, Udeshi ND, Olive ME, Carr SA, Root DE, McFarland JM, Vazquez F, Hahn WC.
Cancer Discov. 2023 Mar 1;13(3):766-795. doi: 10.1158/2159-8290.CD-22-1230.
PubMed
Associated Plasmids |
| The lncRNA LUCAT1 is elevated in inflammatory disease and restrains inflammation by regulating the splicing and stability of NR4A2. Vierbuchen T, Agarwal S, Johnson JL, Galia L, Lei X, Stein K, Olagnier D, Gaede KI, Herzmann C, Holm CK, Heine H, Pai A, O'Hara Hall A, Hoebe K, Fitzgerald KA. Proc Natl Acad Sci U S A. 2023 Jan 3;120(1):e2213715120. doi: 10.1073/pnas.2213715120. Epub 2022 Dec 28. PubMed |
| Loss of furin site enhances SARS-CoV-2 spike protein pseudovirus infection. Wang Z, Zhong K, Wang G, Lu Q, Li H, Wu Z, Zhang Z, Yang N, Zheng M, Wang Y, Nie C, Zhou L, Tong A. Gene. 2023 Mar 10;856:147144. doi: 10.1016/j.gene.2022.147144. Epub 2022 Dec 25. PubMed |
| SARS-CoV-2 replication in airway epithelia requires motile cilia and microvillar reprogramming. Wu CT, Lidsky PV, Xiao Y, Cheng R, Lee IT, Nakayama T, Jiang S, He W, Demeter J, Knight MG, Turn RE, Rojas-Hernandez LS, Ye C, Chiem K, Shon J, Martinez-Sobrido L, Bertozzi CR, Nolan GP, Nayak JV, Milla C, Andino R, Jackson PK. Cell. 2023 Jan 5;186(1):112-130.e20. doi: 10.1016/j.cell.2022.11.030. Epub 2022 Dec 2. PubMed |
| Identification of 5' upstream sequence involved in HSPBP1 gene transcription and its downregulation during HIV-1 infection. Iyer K, Mitra A, Mitra D. Virus Res. 2023 Jan 15;324:199034. doi: 10.1016/j.virusres.2022.199034. Epub 2022 Dec 26. PubMed |
| Generation of Induced Pluripotent Stem Cells from Lymphoblastoid Cell Lines by Electroporation of Episomal Vectors. Kim M, Park J, Kim S, Han DW, Shin B, Scholer HR, Kim J, Kim KP. Int J Stem Cells. 2023 Feb 28;16(1):36-43. doi: 10.15283/ijsc22177. Epub 2022 Dec 31. PubMed |
| High p62 expression suppresses the NLRP1 inflammasome and increases stress resistance in cutaneous SCC cells. Hennig P, Di Filippo M, Bilfeld G, Mellett M, Beer HD. Cell Death Dis. 2022 Dec 29;13(12):1077. doi: 10.1038/s41419-022-05530-0. PubMed |
| p53 regulates lysosomal membrane permeabilization as well as cytoprotective autophagy in response to DNA-damaging drugs. Yamashita G, Takano N, Kazama H, Tsukahara K, Miyazawa K. Cell Death Discov. 2022 Dec 29;8(1):502. doi: 10.1038/s41420-022-01293-x. PubMed |
| A novel intergenic enhancer that regulates Bdnf expression in developing cortical neurons. Brookes E, Martinez De La Cruz B, Boulasiki P, Au HYA, Varsally W, Barrington C, Hadjur S, Riccio A. iScience. 2022 Dec 1;26(1):105695. doi: 10.1016/j.isci.2022.105695. eCollection 2023 Jan 20. PubMed |
| Fine-grained, nonlinear registration of live cell movies reveals spatiotemporal organization of diffuse molecular processes. Jiang X, Isogai T, Chi J, Danuser G. PLoS Comput Biol. 2022 Dec 30;18(12):e1009667. doi: 10.1371/journal.pcbi.1009667. eCollection 2022 Dec. PubMed |
| Genetic and pharmacological modulation of DNA mismatch repair heterogeneous tumors promotes immune surveillance. Amodio V, Lamba S, Chila R, Cattaneo CM, Mussolin B, Corti G, Rospo G, Berrino E, Tripodo C, Pisati F, Bartolini A, Aquilano MC, Marsoni S, Mauri G, Marchio C, Abrignani S, Di Nicolantonio F, Germano G, Bardelli A. Cancer Cell. 2023 Jan 9;41(1):196-209.e5. doi: 10.1016/j.ccell.2022.12.003. Epub 2022 Dec 29. PubMed |
| Virus-like particle - mediated delivery of the RIG-I agonist M8 induces a type I interferon response and protects cells against viral infection. Palermo E, Alexandridi M, Di Carlo D, Muscolini M, Hiscott J. Front Cell Infect Microbiol. 2022 Dec 14;12:1079926. doi: 10.3389/fcimb.2022.1079926. eCollection 2022. PubMed |
| Expression of TRX1 optimizes the antitumor functions of human CAR T cells and confers resistance to a pro-oxidative tumor microenvironment. Balta E, Janzen N, Kirchgessner H, Toufaki V, Orlik C, Liang J, Lairikyengbam D, Abken H, Niesler B, Muller-Decker K, Ruppert T, Samstag Y. Front Immunol. 2022 Dec 14;13:1063313. doi: 10.3389/fimmu.2022.1063313. eCollection 2022. PubMed |
| RUNX2 stabilization by long non-coding RNAs contributes to hypertrophic changes in human chondrocytes. Yoon DS, Kim EJ, Cho S, Jung S, Lee KM, Park KH, Lee JW, Kim SH. Int J Biol Sci. 2023 Jan 1;19(1):13-33. doi: 10.7150/ijbs.74895. eCollection 2023. PubMed |
| Mouse embryonic stem cell-derived motor neurons are susceptible to ferroptosis. Martinez AM, Kim A, Flores CA, Rahman DF, Yang WS. FEBS Open Bio. 2023 Mar;13(3):419-433. doi: 10.1002/2211-5463.13545. Epub 2023 Jan 24. PubMed |
| Sec22b is a critical and nonredundant regulator of plasma cell maintenance. Bonaud A, Gargowitsch L, Gilbert SM, Rajan E, Canales-Herrerias P, Stockholm D, Rahman NF, Collins MO, Taskiran H, Hill DL, Alloatti A, Alouche N, Balor S, Soldan V, Gillet D, Barbier J, Bachelerie F, Smith KGC, Jellusova J, Bruhns P, Amigorena S, Balabanian K, Linterman MA, Peden AA, Espeli M. Proc Natl Acad Sci U S A. 2023 Jan 10;120(2):e2213056120. doi: 10.1073/pnas.2213056120. Epub 2023 Jan 3. PubMed |
| PAQR8 promotes breast cancer recurrence and confers resistance to multiple therapies. Chen S, Paul MR, Sterner CJ, Belka GK, Wang D, Xu P, Sreekumar A, Pan TC, Pant DK, Makhlin I, DeMichele A, Mesaros C, Chodosh LA. Breast Cancer Res. 2023 Jan 3;25(1):1. doi: 10.1186/s13058-022-01559-3. PubMed |
Small Molecule-Activated O-GlcNAcase for Spatiotemporal Removal of O-GlcNAc in Live Cells.
Ge Y, Lu H, Yang B, Woo CM.
ACS Chem Biol. 2023 Jan 4. doi: 10.1021/acschembio.2c00894.
PubMed
Associated Plasmids |
| CLASP2 recognizes tubulins exposed at the microtubule plus-end in a nucleotide state-sensitive manner. Luo W, Demidov V, Shen Q, Girao H, Chakraborty M, Maiorov A, Ataullakhanov FI, Lin C, Maiato H, Grishchuk EL. Sci Adv. 2023 Jan 4;9(1):eabq5404. doi: 10.1126/sciadv.abq5404. Epub 2023 Jan 4. PubMed |
| Metabolic regulation of species-specific developmental rates. Diaz-Cuadros M, Miettinen TP, Skinner OS, Sheedy D, Diaz-Garcia CM, Gapon S, Hubaud A, Yellen G, Manalis SR, Oldham WM, Pourquie O. Nature. 2023 Jan;613(7944):550-557. doi: 10.1038/s41586-022-05574-4. Epub 2023 Jan 4. PubMed |
| FHL3 promotes the formation of fast glycolytic muscle fibers by interacting with YY1 and muscle glycolytic metabolism. Bai W, Zhang Y, Ma J, Du M, Xu H, Wang J, Zhang L, Li W, Hou Y, Liu X, Zhang X, Peng Y, Li J, Zhan X, Jiang W, Liu S, Liu X, Li Q, Miao Y, Sui M, Yang Y, Zhang S, Xu Z, Zuo B. Cell Mol Life Sci. 2023 Jan 5;80(1):27. doi: 10.1007/s00018-022-04680-w. PubMed |
| Nuclear accumulation of host transcripts during Zika Virus Infection. Leon KE, Khalid MM, Flynn RA, Fontaine KA, Nguyen TT, Kumar GR, Simoneau CR, Tomar S, Jimenez-Morales D, Dunlap M, Kaye J, Shah PS, Finkbeiner S, Krogan NJ, Bertozzi C, Carette JE, Ott M. PLoS Pathog. 2023 Jan 5;19(1):e1011070. doi: 10.1371/journal.ppat.1011070. eCollection 2023 Jan. PubMed |
| Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome. Unda BK, Chalil L, Yoon S, Kilpatrick S, Irwin C, Xing S, Murtaza N, Cheng A, Brown C, Afonso A, McCready E, Ronen GM, Howe J, Caye-Eude A, Verloes A, Doble BW, Faivre L, Vitobello A, Scherer SW, Lu Y, Penzes P, Singh KK. Mol Psychiatry. 2023 Jan 6. doi: 10.1038/s41380-022-01937-5. PubMed |
| Efficient and error-free correction of sickle mutation in human erythroid cells using prime editor-2. George A, Ravi NS, Prasad K, Panigrahi L, Koikkara S, Rajendiran V, Devaraju N, Paul J, Pai AA, Nakamura Y, Kurita R, Balasubramanian P, Thangavel S, Marepally S, Velayudhan SR, Srivastava A, Mohankumar KM. Front Genome Ed. 2022 Dec 20;4:1085111. doi: 10.3389/fgeed.2022.1085111. eCollection 2022. PubMed |
| Proximity biotinylation to define the local environment of the protein kinase A catalytic subunit in adrenal cells. Omar MH, Lauer SM, Lau HT, Golkowski M, Ong SE, Scott JD. STAR Protoc. 2023 Jan 4;4(1):101992. doi: 10.1016/j.xpro.2022.101992. PubMed |
| Integrative characterisation of secreted factors involved in intercellular communication between prostate epithelial or cancer cells and fibroblasts. Wu Y, Clark KC, Niranjan B, Chueh AC, Horvath LG, Taylor RA, Daly RJ. Mol Oncol. 2023 Mar;17(3):469-486. doi: 10.1002/1878-0261.13376. Epub 2023 Jan 27. PubMed |
| METTL16 drives leukemogenesis and leukemia stem cell self-renewal by reprogramming BCAA metabolism. Han L, Dong L, Leung K, Zhao Z, Li Y, Gao L, Chen Z, Xue J, Qing Y, Li W, Pokharel SP, Gao M, Chen M, Shen C, Tan B, Small A, Wang K, Zhang Z, Qin X, Yang L, Wunderlich M, Zhang B, Mulloy JC, Marcucci G, Chen CW, Wei M, Su R, Chen J, Deng X. Cell Stem Cell. 2023 Jan 5;30(1):52-68.e13. doi: 10.1016/j.stem.2022.12.006. PubMed |
| A distal super-enhancer activates oncogenic ETS2 via recruiting MECOM in inflammatory bowel disease and colorectal cancer. Chen Y, Ying Y, Wang M, Ma C, Jia M, Shi L, Wang S, Zheng X, Chen W, Shu XS. Cell Death Dis. 2023 Jan 6;14(1):8. doi: 10.1038/s41419-022-05513-1. PubMed |
| Antagonistic action of GPS2 and KDM1A at enhancers governs alternative macrophage activation by interleukin 4. Huang Z, Efthymiadou A, Liang N, Fan R, Treuter E. Nucleic Acids Res. 2023 Feb 22;51(3):1067-1086. doi: 10.1093/nar/gkac1230. PubMed |
| Rewiring Lipid Metabolism by Targeting PCSK9 and HMGCR to Treat Liver Cancer. Alannan M, Trezeguet V, Amoedo ND, Rossignol R, Mahfouf W, Rezvani HR, Dittrich-Domergue F, Moreau P, Lacomme S, Gontier E, Grosset CF, Badran B, Fayyad-Kazan H, Merched AJ. Cancers (Basel). 2022 Dec 20;15(1):3. doi: 10.3390/cancers15010003. PubMed |
| Alternative splicing mediates the compensatory upregulation of MBNL2 upon MBNL1 loss-of-function. Nitschke L, Hu RC, Miller AN, Lucas L, Cooper TA. Nucleic Acids Res. 2023 Feb 22;51(3):1245-1259. doi: 10.1093/nar/gkac1219. PubMed |
| ERK phosphorylation disrupts the intramolecular interaction of capicua to promote cytoplasmic translocation of capicua and tumor growth. Park J, Park GY, Lee J, Park J, Kim S, Kim E, Park SY, Yoon JH, Lee Y. Front Mol Biosci. 2022 Dec 22;9:1030725. doi: 10.3389/fmolb.2022.1030725. eCollection 2022. PubMed |
| Repeat-associated non-AUG translation induces cytoplasmic aggregation of CAG repeat-containing RNAs. Das MR, Chang Y, Anderson R, Saunders RA, Zhang N, Tomberlin CP, Vale RD, Jain A. Proc Natl Acad Sci U S A. 2023 Jan 17;120(3):e2215071120. doi: 10.1073/pnas.2215071120. Epub 2023 Jan 9. PubMed |
| The mitophagy receptor BNIP3 is critical for the regulation of metabolic homeostasis and mitochondrial function in the nucleus pulposus cells of the intervertebral disc. Madhu V, Hernandez-Meadows M, Boneski PK, Qiu Y, Guntur AR, Kurland IJ, Barve RA, Risbud MV. Autophagy. 2023 Jun;19(6):1821-1843. doi: 10.1080/15548627.2022.2162245. Epub 2023 Jan 10. PubMed |
| MicroRNA-eQTLs in the developing human neocortex link miR-4707-3p expression to brain size. Lafferty MJ, Aygun N, Patel NK, Krupa O, Liang D, Wolter JM, Geschwind DH, de la Torre-Ubieta L, Stein JL. Elife. 2023 Jan 11;12:e79488. doi: 10.7554/eLife.79488. PubMed |
| Cytokinesis machinery promotes cell dissociation from collectively migrating strands in confinement. Law RA, Kiepas A, Desta HE, Perez Ipina E, Parlani M, Lee SJ, Yankaskas CL, Zhao R, Mistriotis P, Wang N, Gu Z, Kalab P, Friedl P, Camley BA, Konstantopoulos K. Sci Adv. 2023 Jan 13;9(2):eabq6480. doi: 10.1126/sciadv.abq6480. Epub 2023 Jan 11. PubMed |
| ZNF185 prevents stress fiber formation through the inhibition of RhoA in endothelial cells. Suzuki S, Ando F, Kitagawa S, Hara Y, Fujiki T, Mandai S, Susa K, Mori T, Sohara E, Rai T, Uchida S. Commun Biol. 2023 Jan 11;6(1):29. doi: 10.1038/s42003-023-04416-x. PubMed |
| Upregulation of LRRC8A by m(5)C modification-mediated mRNA stability suppresses apoptosis and facilitates tumorigenesis in cervical cancer. Chen Y, Zuo X, Wei Q, Xu J, Liu X, Liu S, Wang H, Luo Q, Wang Y, Yang Y, Zhao H, Xu J, Liu T, Yi P. Int J Biol Sci. 2023 Jan 1;19(2):691-704. doi: 10.7150/ijbs.79205. eCollection 2023. PubMed |
| PRR14 organizes H3K9me3-modified heterochromatin at the nuclear lamina. Kiseleva AA, Cheng YC, Smith CL, Katz RA, Poleshko A. Nucleus. 2023 Dec;14(1):2165602. doi: 10.1080/19491034.2023.2165602. PubMed |
| Loss of RREB1 in pancreatic beta cells reduces cellular insulin content and affects endocrine cell gene expression. Mattis KK, Krentz NAJ, Metzendorf C, Abaitua F, Spigelman AF, Sun H, Ikle JM, Thaman S, Rottner AK, Bautista A, Mazzaferro E, Perez-Alcantara M, Manning Fox JE, Torres JM, Wesolowska-Andersen A, Yu GZ, Mahajan A, Larsson A, MacDonald PE, Davies B, den Hoed M, Gloyn AL. Diabetologia. 2023 Apr;66(4):674-694. doi: 10.1007/s00125-022-05856-6. Epub 2023 Jan 12. PubMed |
| Exosomes mediate Coxsackievirus B3 transmission and expand the viral tropism. Fu Y, Xiong S. PLoS Pathog. 2023 Jan 12;19(1):e1011090. doi: 10.1371/journal.ppat.1011090. eCollection 2023 Jan. PubMed |
| Kaposi's sarcoma-associated herpesvirus (KSHV) utilizes the NDP52/CALCOCO2 selective autophagy receptor to disassemble processing bodies. Robinson CA, Singh GK, Kleer M, Katsademas T, Castle EL, Boudreau BQ, Corcoran JA. PLoS Pathog. 2023 Jan 12;19(1):e1011080. doi: 10.1371/journal.ppat.1011080. eCollection 2023 Jan. PubMed |
| HERC1 deficiency causes osteopenia through transcriptional program dysregulation during bone remodeling. Pedrazza L, Martinez-Martinez A, Sanchez-de-Diego C, Valer JA, Pimenta-Lopes C, Sala-Gaston J, Szpak M, Tyler-Smith C, Ventura F, Rosa JL. Cell Death Dis. 2023 Jan 12;14(1):17. doi: 10.1038/s41419-023-05549-x. PubMed |
| A non-catalytic N-terminus domain of WRN prevents mitotic telomere deprotection. Romero-Zamora D, Hayashi MT. Sci Rep. 2023 Jan 12;13(1):645. doi: 10.1038/s41598-023-27598-0. PubMed |
| Small molecule agonist of mitochondrial fusion repairs mitochondrial dysfunction. Guo Y, Zhang H, Yan C, Shen B, Zhang Y, Guo X, Sun S, Yu F, Yan J, Liu R, Zhang Q, Zhang D, Liu H, Liu Y, Zhang Y, Li W, Qin J, Lv H, Wang Z, Yuan Y, Yang JF, Zhong YT, Gao S, Zhou B, Liu L, Kong D, Hao X, Hu J, Chen Q. Nat Chem Biol. 2023 Apr;19(4):468-477. doi: 10.1038/s41589-022-01224-y. Epub 2023 Jan 12. PubMed |
| Escape from NK cell tumor surveillance by NGFR-induced lipid remodeling in melanoma. Lehmann J, Caduff N, Krzywinska E, Stierli S, Salas-Bastos A, Loos B, Levesque MP, Dummer R, Stockmann C, Munz C, Diener J, Sommer L. Sci Adv. 2023 Jan 13;9(2):eadc8825. doi: 10.1126/sciadv.adc8825. Epub 2023 Jan 13. PubMed |
| KDM6A Loss Triggers an Epigenetic Switch That Disrupts Urothelial Differentiation and Drives Cell Proliferation in Bladder Cancer. Qiu H, Makarov V, Bolzenius JK, Halstead A, Parker Y, Wang A, Iyer GV, Wise H, Kim D, Thayaparan V, Lindner DJ, Haber GP, Ting AH, Ren B, Chan TA, Arora V, Solit DB, Lee BH. Cancer Res. 2023 Mar 15;83(6):814-829. doi: 10.1158/0008-5472.CAN-22-1444. PubMed |
Genome-scale CRISPR screening in a single mouse liver.
Keys HR, Knouse KA.
Cell Genom. 2022 Dec 14;2(12):100217. doi: 10.1016/j.xgen.2022.100217. Epub 2022 Nov 15.
PubMed
Associated Plasmids |
| Expansion of interferon inducible gene pool via USP18 inhibition promotes cancer cell pyroptosis. Arimoto KI, Miyauchi S, Troutman TD, Zhang Y, Liu M, Stoner SA, Davis AG, Fan JB, Huang YJ, Yan M, Glass CK, Zhang DE. Nat Commun. 2023 Jan 17;14(1):251. doi: 10.1038/s41467-022-35348-5. PubMed |
| Massively parallel identification of mRNA localization elements in primary cortical neurons. Mendonsa S, von Kugelgen N, Dantsuji S, Ron M, Breimann L, Baranovskii A, Lodige I, Kirchner M, Fischer M, Zerna N, Bujanic L, Mertins P, Ulitsky I, Chekulaeva M. Nat Neurosci. 2023 Mar;26(3):394-405. doi: 10.1038/s41593-022-01243-x. Epub 2023 Jan 16. PubMed |
Predicting prime editing efficiency and product purity by deep learning.
Mathis N, Allam A, Kissling L, Marquart KF, Schmidheini L, Solari C, Balazs Z, Krauthammer M, Schwank G.
Nat Biotechnol. 2023 Jan 16. doi: 10.1038/s41587-022-01613-7.
PubMed
Associated Plasmids |
| CRISPR-screen identifies ZIP9 and dysregulated Zn2+ homeostasis as a cause of cancer-associated changes in glycosylation. Romer TB, Khoder-Agha F, Aasted MKM, de Haan N, Horn S, Dylander A, Zhang T, Pallesen EMH, Dabelsteen S, Wuhrer M, Hogsbro CF, Thomsen EA, Mikkelsen JG, Wandall HH. Glycobiology. 2023 Jan 16:cwad003. doi: 10.1093/glycob/cwad003. PubMed |
| Active enhancers strengthen insulation by RNA-mediated CTCF binding at chromatin domain boundaries. Islam Z, Saravanan B, Walavalkar K, Farooq U, Singh AK, Radhakrishnan S, Thakur J, Pandit A, Henikoff S, Notani D. Genome Res. 2023 Jan;33(1):1-17. doi: 10.1101/gr.276643.122. Epub 2023 Jan 17. PubMed |
| A RIPK3-independent role of MLKL in suppressing parthanatos promotes immune evasion in hepatocellular carcinoma. Jiang X, Deng W, Tao S, Tang Z, Chen Y, Tian M, Wang T, Tao C, Li Y, Fang Y, Pu C, Gao J, Wang X, Qu W, Gai X, Ding Z, Fu Y, Zheng Y, Cao S, Zhou J, Huang M, Liu W, Xu J, Fan J, Shi Y. Cell Discov. 2023 Jan 17;9(1):7. doi: 10.1038/s41421-022-00504-0. PubMed |
| CRISPR screens reveal genetic determinants of PARP inhibitor sensitivity and resistance in prostate cancer. Tsujino T, Takai T, Hinohara K, Gui F, Tsutsumi T, Bai X, Miao C, Feng C, Gui B, Sztupinszki Z, Simoneau A, Xie N, Fazli L, Dong X, Azuma H, Choudhury AD, Mouw KW, Szallasi Z, Zou L, Kibel AS, Jia L. Nat Commun. 2023 Jan 17;14(1):252. doi: 10.1038/s41467-023-35880-y. PubMed |
| Dual mTORC1/2 Inhibition Synergistically Enhances AML Cell Death in Combination with the BCL2 Antagonist Venetoclax. Satta T, Li L, Chalasani SL, Hu X, Nkwocha J, Sharma K, Kmieciak M, Rahmani M, Zhou L, Grant S. Clin Cancer Res. 2023 Apr 3;29(7):1332-1343. doi: 10.1158/1078-0432.CCR-22-2729. PubMed |
| Use of Ecto-Tagged Integrins to Monitor Integrin Exocytosis and Endocytosis. Huet-Calderwood C, Rivera-Molina F, Toomre D, Calderwood DA. Methods Mol Biol. 2023;2608:17-38. doi: 10.1007/978-1-0716-2887-4_2. PubMed |
| HER2-driven breast cancer suppression by the JNK signaling pathway. Itah Z, Chaudhry S, Raju Ponny S, Aydemir O, Lee A, Cavanagh-Kyros J, Tournier C, Muller WJ, Davis RJ. Proc Natl Acad Sci U S A. 2023 Jan 24;120(4):e2218373120. doi: 10.1073/pnas.2218373120. Epub 2023 Jan 19. PubMed |
| PXR triggers YAP-TEAD binding and Sirt2-driven YAP deacetylation and polyubiquitination to promote liver enlargement and regeneration in mice. Zhang S, Guo M, Jiang X, Tang L, Wu T, Bi G, Yang X, Fan S, Bi H. Pharmacol Res. 2023 Feb;188:106666. doi: 10.1016/j.phrs.2023.106666. Epub 2023 Jan 16. PubMed |
| IRF8 Regulates Intrinsic Ferroptosis through Repressing p53 Expression to Maintain Tumor Cell Sensitivity to Cytotoxic T Lymphocytes. Poschel DB, Kehinde-Ige M, Klement JD, Yang D, Merting AD, Savage NM, Shi H, Liu K. Cells. 2023 Jan 13;12(2):310. doi: 10.3390/cells12020310. PubMed |
| Characterization of Hepatoma-Derived Growth Factor-Related Protein 2 Interactions with Heterochromatin. Wistner SC, MacDonald IA, Stanley KA, Hathaway NA. Cells. 2023 Jan 14;12(2):325. doi: 10.3390/cells12020325. PubMed |
| Jatrophane Diterpenoids from Euphorbia peplus Linn. as Activators of Autophagy and Inhibitors of Tau Pathology. Yan Y, Zhou Q, Ran X, Lu Q, Zhang C, Peng M, Tang L, Luo R, Di Y, Hao X. Int J Mol Sci. 2023 Jan 6;24(2):1088. doi: 10.3390/ijms24021088. PubMed |
| A Missense Variation in PHACTR2 Associates with Impaired Actin Dynamics, Dilated Cardiomyopathy, and Left Ventricular Non-Compaction in Humans. Majdalani P, Levitas A, Krymko H, Slanovic L, Braiman A, Hadad U, Dabsan S, Horev A, Zarivach R, Parvari R. Int J Mol Sci. 2023 Jan 10;24(2):1388. doi: 10.3390/ijms24021388. PubMed |
| Establishment of a neutralization assay for Nipah virus using a high-titer pseudovirus system. Luo X, Wang C, Huang Y, Cong S, Tan J, Hou W, Ma F, Zheng L. Biotechnol Lett. 2023 Apr;45(4):489-498. doi: 10.1007/s10529-023-03351-5. Epub 2023 Jan 21. PubMed |
| Cell differentiation modifies the p53 transcriptional program through a combination of gene silencing and constitutive transactivation. Tatavosian R, Donovan MG, Galbraith MD, Duc HN, Szwarc MM, Joshi MU, Frieman A, Bilousova G, Cao Y, Smith KP, Song K, Rachubinski AL, Andrysik Z, Espinosa JM. Cell Death Differ. 2023 Apr;30(4):952-965. doi: 10.1038/s41418-023-01113-4. Epub 2023 Jan 21. PubMed |
| Ganoapplins A and B with an unprecedented 6/6/6/5/6-fused pentacyclic skeleton from Ganoderma inhibit Tau pathology through activating autophagy. Peng X, Luo R, Ran X, Guo Y, Yao YG, Qiu M. Bioorg Chem. 2023 Mar;132:106375. doi: 10.1016/j.bioorg.2023.106375. Epub 2023 Jan 17. PubMed |
| Enhancing adoptive T-cell therapy with fucoidan-based IL-2 delivery microcapsules. Jeon EY, Choi DS, Choi S, Won JY, Jo Y, Kim HB, Jung Y, Shin SC, Min H, Choi HW, Lee MS, Park Y, Chung JJ, Jin HS. Bioeng Transl Med. 2022 Jul 5;8(1):e10362. doi: 10.1002/btm2.10362. eCollection 2023 Jan. PubMed |
| SARS-CoV-2 Spike protein activates TMEM16F-mediated platelet procoagulant activity. Cappelletto A, Allan HE, Crescente M, Schneider E, Bussani R, Ali H, Secco I, Vodret S, Simeone R, Mascaretti L, Zacchigna S, Warner TD, Giacca M. Front Cardiovasc Med. 2023 Jan 4;9:1013262. doi: 10.3389/fcvm.2022.1013262. eCollection 2022. PubMed |
| Abl2 Kinase Differentially Regulates iGluRs Current Activity and Synaptic Localization. Kabirova M, Reichenstein M, Borovok N, Sheinin A, Gorobets D, Michaelevski I. Cell Mol Neurobiol. 2023 Aug;43(6):2785-2799. doi: 10.1007/s10571-023-01317-9. Epub 2023 Jan 23. PubMed |
| Destabilizing NF1 variants act in a dominant negative manner through neurofibromin dimerization. Young LC, Goldstein de Salazar R, Han SW, Huang ZYS, Merk A, Drew M, Darling J, Wall V, Grisshammer R, Cheng A, Allison MR, Sale MJ, Nissley DV, Esposito D, Ognjenovic J, McCormick F. Proc Natl Acad Sci U S A. 2023 Jan 31;120(5):e2208960120. doi: 10.1073/pnas.2208960120. Epub 2023 Jan 23. PubMed |
Attenuating iPSC reprogramming stress with dominant-negative BET peptides.
Hossain ME, Cevallos RR, Zhang R, Hu K.
iScience. 2022 Dec 28;26(1):105889. doi: 10.1016/j.isci.2022.105889. eCollection 2023 Jan 20.
PubMed
Associated Plasmids |
| Human VH-based chimeric antigen receptor T cells targeting glypican 3 eliminate tumors in preclinical models of HCC. Kolluri A, Li D, Li N, Duan Z, Roberts LR, Ho M. Hepatol Commun. 2023 Jan 18;7(2):e0022. doi: 10.1097/HC9.0000000000000022. eCollection 2023 Feb 1. PubMed |
| Stress granule homeostasis is modulated by TRIM21-mediated ubiquitination of G3BP1 and autophagy-dependent elimination of stress granules. Yang C, Wang Z, Kang Y, Yi Q, Wang T, Bai Y, Liu Y. Autophagy. 2023 Jul;19(7):1934-1951. doi: 10.1080/15548627.2022.2164427. Epub 2023 Jan 24. PubMed |
| Activation of the NLRP1 inflammasome in human keratinocytes by the dsDNA mimetic poly(dA:dT). Zhou JY, Sarkar MK, Okamura K, Harris JE, Gudjonsson JE, Fitzgerald KA. Proc Natl Acad Sci U S A. 2023 Jan 31;120(5):e2213777120. doi: 10.1073/pnas.2213777120. Epub 2023 Jan 24. PubMed |
| Lamin A/C phosphorylation at serine 22 is a conserved heat shock response to regulate nuclear adaptation during stress. Virtanen L, Holm E, Halme M, West G, Lindholm F, Gullmets J, Irjala J, Helio T, Padzik A, Meinander A, Eriksson JE, Taimen P. J Cell Sci. 2023 Feb 15;136(4):jcs259788. doi: 10.1242/jcs.259788. Epub 2023 Feb 27. PubMed |
| Secreted PGK1 and IGFBP2 contribute to the bystander effect of miR-10b gene editing in glioma. Zhang Y, Rabinovsky R, Wei Z, El Fatimy R, Deforzh E, Luan B, Peshkin L, Uhlmann EJ, Krichevsky AM. Mol Ther Nucleic Acids. 2023 Jan 2;31:265-275. doi: 10.1016/j.omtn.2022.12.018. eCollection 2023 Mar 14. PubMed |
| The frequency of differentiated CD3(+)CD27(-)CD28(-) T cells predicts response to CART cell therapy in diffuse large B-cell lymphoma. Worel N, Grabmeier-Pfistershammer K, Kratzer B, Schlager M, Tanzmann A, Rottal A, Kormoczi U, Porpaczy E, Staber PB, Skrabs C, Herkner H, Gudipati V, Huppa JB, Salzer B, Lehner M, Saxenhuber N, Friedberg E, Wohlfarth P, Hopfinger G, Rabitsch W, Simonitsch-Klupp I, Jager U, Pickl WF. Front Immunol. 2023 Jan 9;13:1004703. doi: 10.3389/fimmu.2022.1004703. eCollection 2022. PubMed |
| The endothelial-enriched lncRNA LINC00607 mediates angiogenic function. Boos F, Oo JA, Warwick T, Gunther S, Izquierdo Ponce J, Lopez M, Rafii D, Buchmann G, Pham MD, Msheik ZS, Li T, Seredinski S, Haydar S, Kashefiolasl S, Plate KH, Behr R, Mietsch M, Krishnan J, Pullamsetti SS, Bibli SI, Hinkel R, Baker AH, Boon RA, Schulz MH, Wittig I, Miller FJ Jr, Brandes RP, Leisegang MS. Basic Res Cardiol. 2023 Jan 26;118(1):5. doi: 10.1007/s00395-023-00978-3. PubMed |
| The selective autophagy adaptor p62/SQSTM1 forms phase condensates regulated by HSP27 that facilitate the clearance of damaged lysosomes via lysophagy. Gallagher ER, Holzbaur ELF. Cell Rep. 2023 Feb 28;42(2):112037. doi: 10.1016/j.celrep.2023.112037. Epub 2023 Jan 25. PubMed |
| MiR-130b modulates the invasive, migratory, and metastatic behavior of leiomyosarcoma. Danielson LS, Guijarro MV, Menendez S, Higgins B, Sun Q, Mittal K, Popiolek DA, Overholtzer M, Palmer GD, Hernando E. PLoS One. 2023 Jan 26;18(1):e0278844. doi: 10.1371/journal.pone.0278844. eCollection 2023. PubMed |
| Stonin 2 activates lysosomal-mTOR axis for cell survival in oral cancer. Mahapatra KK, Mishra SR, Dhiman R, Bhutia SK. Toxicol In Vitro. 2023 Apr;88:105561. doi: 10.1016/j.tiv.2023.105561. Epub 2023 Jan 23. PubMed |
| Tumor necroptosis-mediated shedding of cell surface proteins promotes metastasis of breast cancer by suppressing anti-tumor immunity. Liu Z, Choksi S, Kwon HJ, Jiao D, Liu C, Liu ZG. Breast Cancer Res. 2023 Jan 26;25(1):10. doi: 10.1186/s13058-023-01604-9. PubMed |
| A modular CRISPR screen identifies individual and combination pathways contributing to HIV-1 latency. Hsieh E, Janssens DH, Paddison PJ, Browne EP, Henikoff S, OhAinle M, Emerman M. PLoS Pathog. 2023 Jan 27;19(1):e1011101. doi: 10.1371/journal.ppat.1011101. eCollection 2023 Jan. PubMed |
| Targeting Notch1-YAP Circuit Reprograms Macrophage Polarization and Alleviates Acute Liver Injury in Mice. Yang Y, Ni M, Zong R, Yu M, Sun Y, Li J, Chen P, Li C. Cell Mol Gastroenterol Hepatol. 2023;15(5):1085-1104. doi: 10.1016/j.jcmgh.2023.01.002. Epub 2023 Jan 25. PubMed |
| Chromatin complex dependencies reveal targeting opportunities in leukemia. Najm FJ, DeWeirdt P, Moore MM, Bevill SM, El Farran CA, Macias KA, Hegde M, Waterbury AL, Liau BB, van Galen P, Doench JG, Bernstein BE. Nat Commun. 2023 Jan 27;14(1):448. doi: 10.1038/s41467-023-36150-7. PubMed |
| Regulation of beige adipocyte thermogenesis by the cold-repressed ER protein NNAT. Choi KM, Ko CY, An SM, Cho SH, Rowland DJ, Kim JH, Fasoli A, Chaudhari AJ, Bers DM, Yoon JC. Mol Metab. 2023 Mar;69:101679. doi: 10.1016/j.molmet.2023.101679. Epub 2023 Jan 25. PubMed |
| MANF stimulates autophagy and restores mitochondrial homeostasis to treat toxic proteinopathy. Kim Y, Li C, Gu C, Tycksen E, Puri A, Pietka TA, Sivapackiam J, Fang Y, Kidd K, Park SJ, Johnson BG, Kmoch S, Duffield JS, Bleyer AJ, Jackrel ME, Urano F, Sharma V, Lindahl M, Chen YM. bioRxiv [Preprint]. 2023 Jan 12:2023.01.10.523171. doi: 10.1101/2023.01.10.523171. PubMed |
| EHD1-dependent traffic of IGF-1 receptor to the cell surface is essential for Ewing sarcoma tumorigenesis and metastasis. Chakraborty S, Bhat AM, Mushtaq I, Luan H, Kalluchi A, Mirza S, Storck MD, Chaturvedi N, Lopez-Guerrero JA, Llombart-Bosch A, Machado I, Scotlandi K, Meza JL, Ghosal G, Coulter DW, Rowley JM, Band V, Mohapatra BC, Band H. bioRxiv. 2023 Mar 22:2023.01.15.524130. doi: 10.1101/2023.01.15.524130. Preprint. PubMed |
| Coupling During Collective Cell Migration is Controlled by a Vinculin Mechanochemical Switch. Shoyer TC, Gates EM, Cabe JI, Conway DE, Hoffman BD. bioRxiv. 2023 Jan 14:2023.01.13.523997. doi: 10.1101/2023.01.13.523997. Preprint. PubMed |
| Elucidation of the Molecular Basis and Cellular Functions of Vinculin-Actin Directional Catch Bonding. Campbell S, Chirasani V, Khan M, Malavade J, Dokholyan N, Hoffman B. Res Sq. 2023 Jan 12:rs.3.rs-2334490. doi: 10.21203/rs.3.rs-2334490/v1. Preprint. PubMed |
| TSC2 regulates tumor susceptibility to TRAIL-mediated T-cell killing by orchestrating mTOR signaling. Lin CP, Traets JJH, Vredevoogd DW, Visser NL, Peeper DS. EMBO J. 2023 Mar 1;42(5):e111614. doi: 10.15252/embj.2022111614. Epub 2023 Jan 30. PubMed |
| LKB1-Dependent Regulation of TPI1 Creates a Divergent Metabolic Liability between Human and Mouse Lung Adenocarcinoma. Stein BD, Ferrarone JR, Gardner EE, Chang JW, Wu D, Hollstein PE, Liang RJ, Yuan M, Chen Q, Coukos JS, Sindelar M, Ngo B, Gross SS, Shaw RJ, Zhang C, Asara JM, Moellering RE, Varmus H, Cantley LC. Cancer Discov. 2023 Apr 3;13(4):1002-1025. doi: 10.1158/2159-8290.CD-22-0805. PubMed |
| YAP1 and WWTR1 expression inversely correlates with neuroendocrine markers in Merkel cell carcinoma. Frost TC, Gartin AK, Liu M, Cheng J, Dharaneeswaran H, Keskin DB, Wu CJ, Giobbie-Hurder A, Thakuria M, DeCaprio JA. J Clin Invest. 2023 Mar 1;133(5):e157171. doi: 10.1172/JCI157171. PubMed |
| KDM6 demethylases integrate DNA repair gene regulation and loss of KDM6A sensitizes human acute myeloid leukemia to PARP and BCL2 inhibition. Boila LD, Ghosh S, Bandyopadhyay SK, Jin L, Murison A, Zeng AGX, Shaikh W, Bhowmik S, Muddineni SSNA, Biswas M, Sinha S, Chatterjee SS, Mbong N, Gan OI, Bose A, Chakraborty S, Arruda A, Kennedy JA, Mitchell A, Lechman ER, Banerjee D, Milyavsky M, Minden MD, Dick JE, Sengupta A. Leukemia. 2023 Jan 31. doi: 10.1038/s41375-023-01833-z. PubMed |
| A genome-wide CRISPR functional survey of the human phagocytosis molecular machinery. Essletzbichler P, Sedlyarov V, Frommelt F, Soulat D, Heinz LX, Stefanovic A, Neumayer B, Superti-Furga G. Life Sci Alliance. 2023 Feb 1;6(4):e202201715. doi: 10.26508/lsa.202201715. Print 2023 Apr. PubMed |
| Skeletal diseases caused by mutations in PTH1R show aberrant differentiation of skeletal progenitors due to dysregulation of DEPTOR. Csukasi F, Bosakova M, Barta T, Martin JH, Arcedo J, Barad M, Rico-Llanos GA, Zieba J, Becerra J, Krejci P, Duran I, Krakow D. Front Cell Dev Biol. 2023 Jan 16;10:963389. doi: 10.3389/fcell.2022.963389. eCollection 2022. PubMed |
| Species-specific regulation of XIST by the JPX/FTX orthologs. Rosspopoff O, Cazottes E, Huret C, Loda A, Collier AJ, Casanova M, Rugg-Gunn PJ, Heard E, Ouimette JF, Rougeulle C. Nucleic Acids Res. 2023 Mar 21;51(5):2177-2194. doi: 10.1093/nar/gkad029. PubMed |
| Syntaxin 11 Contributes to the Interferon-Inducible Restriction of Coxiella burnetii Intracellular Infection. Ganesan S, Alvarez NN, Steiner S, Fowler KM, Corona AK, Roy CR. mBio. 2023 Feb 28;14(1):e0354522. doi: 10.1128/mbio.03545-22. Epub 2023 Feb 2. PubMed |
| CCPG1 recognizes endoplasmic reticulum luminal proteins for selective ER-phagy. Ishii S, Chino H, Ode KL, Kurikawa Y, Ueda HR, Matsuura A, Mizushima N, Itakura E. Mol Biol Cell. 2023 Apr 1;34(4):ar29. doi: 10.1091/mbc.E22-09-0432. Epub 2023 Feb 3. PubMed |
Spatial regulation of the glycocalyx component podocalyxin is a switch for prometastatic function.
Roman-Fernandez A, Mansour MA, Kugeratski FG, Anand J, Sandilands E, Galbraith L, Rakovic K, Freckmann EC, Cumming EM, Park J, Nikolatou K, Lilla S, Shaw R, Strachan D, Mason S, Patel R, McGarry L, Katoch A, Campbell KJ, Nixon C, Miller CJ, Leung HY, Le Quesne J, Norman JC, Zanivan S, Blyth K, Bryant DM.
Sci Adv. 2023 Feb 3;9(5):eabq1858. doi: 10.1126/sciadv.abq1858. Epub 2023 Feb 3.
PubMed
Associated Plasmids |
| A Virus-Packageable CRISPR System Identifies Host Dependency Factors Co-Opted by Multiple HIV-1 Strains. Montoya VR, Ready TM, Felton A, Fine SR, OhAinle M, Emerman M. mBio. 2023 Feb 28;14(1):e0000923. doi: 10.1128/mbio.00009-23. Epub 2023 Feb 6. PubMed |
| Differential modularity of the mammalian Engrailed 1 enhancer network directs sweat gland development. Aldea D, Kokalari B, Atsuta Y, Dingwall HL, Zheng Y, Nace A, Cotsarelis G, Kamberov YG. PLoS Genet. 2023 Feb 6;19(2):e1010614. doi: 10.1371/journal.pgen.1010614. eCollection 2023 Feb. PubMed |
| Notch1 cortical signaling regulates epithelial architecture and cell-cell adhesion. White MJ, Jacobs KA, Singh T, Kutys ML. bioRxiv. 2023 Jan 23:2023.01.23.524428. doi: 10.1101/2023.01.23.524428. Preprint. PubMed |
| Prdm6 drives ductus arteriosus closure by promoting ductus arteriosus smooth muscle cell identity and contractility. Zou M, Mangum KD, Magin JC, Cao HH, Yarboro MT, Shelton EL, Taylor JM, Reese J, Furey TS, Mack CP. JCI Insight. 2023 Mar 8;8(5):e163454. doi: 10.1172/jci.insight.163454. PubMed |
| Murine Gammaherpesvirus 68 ORF45 Stimulates B2 Retrotransposon and Pre-tRNA Activation in a Manner Dependent on Mitogen-Activated Protein Kinase (MAPK) Signaling. Lari A, Glaunsinger BA. Microbiol Spectr. 2023 Feb 8:e0017223. doi: 10.1128/spectrum.00172-23. PubMed |
| Type I Interferonopathy due to a Homozygous Loss-of-Inhibitory Function Mutation in STAT2. Zhu G, Badonyi M, Franklin L, Seabra L, Rice GI, Anne-Boland-Auge, Deleuze JF, El-Chehadeh S, Anheim M, de Saint-Martin A, Pellegrini S, Marsh JA, Crow YJ, El-Daher MT. J Clin Immunol. 2023 May;43(4):808-818. doi: 10.1007/s10875-023-01445-3. Epub 2023 Feb 8. PubMed |
| PP2Ac/STRN4 negatively regulates STING-type I IFN signaling in tumor-associated macrophages. Ho WS, Mondal I, Xu B, Das O, Sun R, Chiou P, Cai X, Tahmasebinia F, McFadden E, Wu CY, Wu Z, Matsui W, Lim M, Meng Z, Lu RO. J Clin Invest. 2023 Mar 15;133(6):e162139. doi: 10.1172/JCI162139. PubMed |
| Fibroblast-expressed LRRC15 is a receptor for SARS-CoV-2 spike and controls antiviral and antifibrotic transcriptional programs. Loo L, Waller MA, Moreno CL, Cole AJ, Stella AO, Pop OT, Jochum AK, Ali OH, Denes CE, Hamoudi Z, Chung F, Aggarwal A, Low JKK, Patel K, Siddiquee R, Kang T, Mathivanan S, Mackay JP, Jochum W, Flatz L, Hesselson D, Turville S, Neely GG. PLoS Biol. 2023 Feb 9;21(2):e3001967. doi: 10.1371/journal.pbio.3001967. eCollection 2023 Feb. PubMed |
| ZBTB12 is a molecular barrier to dedifferentiation in human pluripotent stem cells. Han D, Liu G, Oh Y, Oh S, Yang S, Mandjikian L, Rani N, Almeida MC, Kosik KS, Jang J. Nat Commun. 2023 Feb 9;14(1):632. doi: 10.1038/s41467-023-36178-9. PubMed |
| ERdj5 protects goblet cells from endoplasmic reticulum stress-mediated apoptosis under inflammatory conditions. Jeong H, Hong EH, Ahn JH, Cho J, Jeong JH, Kim CW, Yoon BI, Koo JH, Park YY, Yang YM, Iwawaki T, Vallance BA, Chang SY, Ko HJ. Exp Mol Med. 2023 Feb;55(2):401-412. doi: 10.1038/s12276-023-00945-x. Epub 2023 Feb 9. PubMed |
The PROTECTOR strategy employs dCas orthologs to sterically shield off-target sites from CRISPR/Cas activity.
Sapozhnikov DM, Szyf M.
Sci Rep. 2023 Feb 9;13(1):2280. doi: 10.1038/s41598-023-29332-2.
PubMed
Associated Plasmids |
| Decoupling peptide binding from T cell receptor recognition with engineered chimeric MHC-I molecules. Papadaki GF, Ani O, Florio TJ, Young MC, Danon JN, Sun Y, Dersh D, Sgourakis NG. Front Immunol. 2023 Jan 25;14:1116906. doi: 10.3389/fimmu.2023.1116906. eCollection 2023. PubMed |
| Cell cycle-dependent palmitoylation of protocadherin 7 by ZDHHC5 promotes successful cytokinesis. Ozkan NE, Yigit BN, Degirmenci BS, Qureshi MH, Yapici GN, Kamacioglu A, Bavili N, Kiraz A, Ozlu N. J Cell Sci. 2023 Mar 15;136(6):jcs260266. doi: 10.1242/jcs.260266. Epub 2023 Mar 20. PubMed |
| Regulatory dissection of the severe COVID-19 risk locus introgressed by Neanderthals. Jagoda E, Marnetto D, Senevirathne G, Gonzalez V, Baid K, Montinaro F, Richard D, Falzarano D, LeBlanc EV, Colpitts CC, Banerjee A, Pagani L, Capellini TD. Elife. 2023 Feb 10;12:e71235. doi: 10.7554/eLife.71235. PubMed |
| The NOTCH-RIPK4-IRF6-ELOVL4 Axis Suppresses Squamous Cell Carcinoma. Yan Y, Gauthier MA, Malik A, Fotiadou I, Ostrovski M, Dervovic D, Ghadban L, Tsai R, Gish G, Loganathan SK, Schramek D. Cancers (Basel). 2023 Jan 25;15(3):737. doi: 10.3390/cancers15030737. PubMed |
| Repurposing the Bis-Biguanide Alexidine in Combination with Tyrosine Kinase Inhibitors to Eliminate Leukemic Stem/Progenitor Cells in Chronic Myeloid Leukemia. Muselli F, Mourgues L, Rochet N, Nebout M, Guerci A, Verhoeyen E, Krug A, Legros L, Peyron JF, Mary D. Cancers (Basel). 2023 Feb 3;15(3):995. doi: 10.3390/cancers15030995. PubMed |
| Novel Local "Off-the-Shelf" Immunotherapy for the Treatment of Myeloma Bone Disease. Charvatova S, Motais B, Czapla J, Cichon T, Smolarczyk R, Walek Z, Giebel S, Hajek R, Bago JR. Cells. 2023 Jan 30;12(3):448. doi: 10.3390/cells12030448. PubMed |
| Epigenetic Regulation of MAP3K8 in EBV-Associated Gastric Carcinoma. Roy G, Yang T, Liu S, Luo YL, Liu Y, Zhong Q. Int J Mol Sci. 2023 Jan 19;24(3):1964. doi: 10.3390/ijms24031964. PubMed |
| Role of Transcription Factor EB in Mitochondrial Dysfunction of Cisplatin-Induced Acute Kidney Injury. Wang S, Chen Y, Wu H, Li X, Xiao H, Pan Q, Liu HF. Int J Mol Sci. 2023 Feb 3;24(3):3028. doi: 10.3390/ijms24033028. PubMed |
| Targeting the E3 ligase NEDD4 as a novel therapeutic strategy for IGF1 signal pathway-driven gastric cancer. Wang K, Yu Y, Wang W, Jiang Y, Li Y, Jiang X, Qiao Y, Chen L, Zhao X, Liu J, Yang A, Li J, Zhang R. Oncogene. 2023 Mar;42(14):1072-1087. doi: 10.1038/s41388-023-02619-4. Epub 2023 Feb 11. PubMed |
| Type 1 diabetes risk genes mediate pancreatic beta cell survival in response to proinflammatory cytokines. Benaglio P, Zhu H, Okino ML, Yan J, Elgamal R, Nariai N, Beebe E, Korgaonkar K, Qiu Y, Donovan MKR, Chiou J, Wang G, Newsome J, Kaur J, Miller M, Preissl S, Corban S, Aylward A, Taipale J, Ren B, Frazer KA, Sander M, Gaulton KJ. Cell Genom. 2022 Nov 11;2(12):100214. doi: 10.1016/j.xgen.2022.100214. eCollection 2022 Dec 14. PubMed |
| m (6) A RNA methylation orchestrates transcriptional dormancy during developmental pausing. Collignon E, Cho B, Fothergill-Robinson J, Furlan G, Ross RL, Limbach PA, Ramalho-Santos M. bioRxiv. 2023 Feb 1:2023.01.30.526234. doi: 10.1101/2023.01.30.526234. Preprint. PubMed |
| High-content image-based CRISPR screening reveals regulators of 3D genome architectures. Hu M, Yang B, Jensen TB, Radda JSD, Cheng Y, Jin S, Wang S. bioRxiv. 2023 Feb 1:2023.01.31.525983. doi: 10.1101/2023.01.31.525983. Preprint. PubMed |
| A Dual Function Antibody Conjugate Enabled Photoimmunotherapy Complements Fluorescence and Photoacoustic Imaging of Head and Neck Cancer Spheroids. Saad MA, Grimaldo-Garcia S, Sweeney A, Mallidi S, Hasan T. bioRxiv. 2023 Feb 2:2023.01.30.526194. doi: 10.1101/2023.01.30.526194. Preprint. PubMed |
| CLU (clusterin) promotes mitophagic degradation of MSX2 through an AKT-DNM1L/Drp1 axis to maintain SOX2-mediated stemness in oral cancer stem cells. Praharaj PP, Patra S, Mishra SR, Mukhopadhyay S, Klionsky DJ, Patil S, Bhutia SK. Autophagy. 2023 Aug;19(8):2196-2216. doi: 10.1080/15548627.2023.2178876. Epub 2023 Mar 6. PubMed |
| CDKAL1 Drives the Maintenance of Cancer Stem-Like Cells by Assembling the eIF4F Translation Initiation Complex. Huang R, Yamamoto T, Nakata E, Ozaki T, Kurozumi K, Wei F, Tomizawa K, Fujimura A. Adv Sci (Weinh). 2023 Apr;10(12):e2206542. doi: 10.1002/advs.202206542. Epub 2023 Feb 14. PubMed |
| Cytoskeletal association of ATP citrate lyase controls the mechanodynamics of macropinocytosis. Puccini J, Wei J, Tong L, Bar-Sagi D. Proc Natl Acad Sci U S A. 2023 Feb 21;120(8):e2213272120. doi: 10.1073/pnas.2213272120. Epub 2023 Feb 14. PubMed |
| Harnessing transcriptionally driven chromosomal instability adaptation to target therapy-refractory lethal prostate cancer. Dhital B, Santasusagna S, Kirthika P, Xu M, Li P, Carceles-Cordon M, Soni RK, Li Z, Hendrickson RC, Schiewer MJ, Kelly WK, Sternberg CN, Luo J, Lujambio A, Cordon-Cardo C, Alvarez-Fernandez M, Malumbres M, Huang H, Ertel A, Domingo-Domenech J, Rodriguez-Bravo V. Cell Rep Med. 2023 Feb 21;4(2):100937. doi: 10.1016/j.xcrm.2023.100937. Epub 2023 Feb 13. PubMed |
| A genome-wide CRISPR-Cas9 knockout screen identifies FSP1 as the warfarin-resistant vitamin K reductase. Jin DY, Chen X, Liu Y, Williams CM, Pedersen LC, Stafford DW, Tie JK. Nat Commun. 2023 Feb 14;14(1):828. doi: 10.1038/s41467-023-36446-8. PubMed |
| Microphysiological model of PIK3CA-driven vascular malformations reveals a role of dysregulated Rac1 and mTORC1/2 in lesion formation. Aw WY, Cho C, Wang H, Cooper AH, Doherty EL, Rocco D, Huang SA, Kubik S, Whitworth CP, Armstrong R, Hickey AJ, Griffith B, Kutys ML, Blatt J, Polacheck WJ. Sci Adv. 2023 Feb 15;9(7):eade8939. doi: 10.1126/sciadv.ade8939. Epub 2023 Feb 15. PubMed |
| A lncRNA-encoded mitochondrial micropeptide exacerbates microglia-mediated neuroinflammation in retinal ischemia/reperfusion injury. Zheng X, Wang M, Liu S, Chen H, Li Y, Yuan F, Yang L, Qiu S, Wang H, Xie Z, Xiang M. Cell Death Dis. 2023 Feb 15;14(2):126. doi: 10.1038/s41419-023-05617-2. PubMed |
| PARP1 associates with R-loops to promote their resolution and genome stability. Laspata N, Kaur P, Mersaoui SY, Muoio D, Liu ZS, Bannister MH, Nguyen HD, Curry C, Pascal JM, Poirier GG, Wang H, Masson JY, Fouquerel E. Nucleic Acids Res. 2023 Mar 21;51(5):2215-2237. doi: 10.1093/nar/gkad066. PubMed |
| Coordinated activation of c-Src and FOXM1 drives tumor cell proliferation and breast cancer progression. Nandi I, Smith HW, Sanguin-Gendreau V, Ji L, Pacis A, Papavasiliou V, Zuo D, Nam S, Attalla SS, Kim SH, Lusson S, Kuasne H, Fortier AM, Savage P, Martinez Ramirez C, Park M, Katzenellenbogen JA, Katzenellenbogen BS, Muller WJ. J Clin Invest. 2023 Apr 3;133(7):e162324. doi: 10.1172/JCI162324. PubMed |
| Prediction of prime editing insertion efficiencies using sequence features and DNA repair determinants. Koeppel J, Weller J, Peets EM, Pallaseni A, Kuzmin I, Raudvere U, Peterson H, Liberante FG, Parts L. Nat Biotechnol. 2023 Feb 16. doi: 10.1038/s41587-023-01678-y. PubMed |
| Pathogen-driven CRISPR screens identify TREX1 as a regulator of DNA self-sensing during influenza virus infection. King CR, Liu Y, Amato KA, Schaack GA, Hu T, Smith JA, Mehle A. bioRxiv. 2023 Feb 7:2023.02.07.527556. doi: 10.1101/2023.02.07.527556. Preprint. PubMed |
| Several cell-intrinsic effectors drive type I interferon-mediated restriction of HIV-1 in primary CD4 (+) T cells. Itell HL, Humes D, Overbaugh J. bioRxiv. 2023 Feb 7:2023.02.07.527545. doi: 10.1101/2023.02.07.527545. Preprint. PubMed |
| Frataxin-deficient human brain microvascular endothelial cells lose polymerized actin and are paracellularly permeable -implications for blood-brain barrier integrity in Friedreich's Ataxia. Smith FM, Kosman DJ. bioRxiv. 2023 Feb 10:2023.02.09.527936. doi: 10.1101/2023.02.09.527936. Preprint. PubMed |
| Cardiomyocyte-fibroblast interaction regulates ferroptosis and fibrosis after myocardial injury. Mohr ME, Li S, Trouten AM, Stairley RA, Roddy PL, Liu C, Zhang M, Sucov HM, Tao G. bioRxiv. 2023 Feb 8:2023.02.07.527364. doi: 10.1101/2023.02.07.527364. Preprint. PubMed |
| Engineered MED12 mutations drive uterine fibroid-like transcriptional and metabolic programs by altering the 3D genome compartmentalization. Buyukcelebi K, Chen X, Abdula F, Duval A, Ozturk H, Seker-Polat F, Jin Q, Yin P, Feng Y, Wei JJ, Bulun S, Yue F, Adli M. Res Sq. 2023 Feb 9:rs.3.rs-2537075. doi: 10.21203/rs.3.rs-2537075/v1. Preprint. PubMed |
| eRNA profiling uncovers the enhancer landscape of oesophageal adenocarcinoma and reveals new deregulated pathways. Ahmed I, Yang SH, Ogden S, Zhang W, Li Y, Sharrocks AD. Elife. 2023 Feb 20;12:e80840. doi: 10.7554/eLife.80840. PubMed |
| Checkpoint TIPE2 Limits the Helper Functions of NK Cells in Supporting Antitumor CD8(+) T Cells. Bi J, Jin X, Zheng C, Huang C, Zhong C, Zheng X, Tian Z, Sun H. Adv Sci (Weinh). 2023 Apr;10(12):e2207499. doi: 10.1002/advs.202207499. Epub 2023 Feb 19. PubMed |
| Disruptions in endocytic traffic contribute to the activation of the NLRP3 inflammasome. Lee B, Hoyle C, Wellens R, Green JP, Martin-Sanchez F, Williams DM, Matchett BJ, Seoane PI, Bennett H, Adamson A, Lopez-Castejon G, Lowe M, Brough D. Sci Signal. 2023 Feb 21;16(773):eabm7134. doi: 10.1126/scisignal.abm7134. Epub 2023 Feb 21. PubMed |
| A group of novel VEGF splice variants as alternative therapeutic targets in renal cell carcinoma. Montemagno C, Durivault J, Gastaldi C, Dufies M, Vial V, He X, Ambrosetti D, Kamenskaya A, Negrier S, Bernhard JC, Borchiellini D, Cao Y, Pages G. Mol Oncol. 2023 Jul;17(7):1379-1401. doi: 10.1002/1878-0261.13401. Epub 2023 Apr 18. PubMed |
| Regulation of cargo exocytosis by a Reps1-Ralbp1-RalA module. Wang S, Chen X, Crisman L, Dou X, Winborn CS, Wan C, Puscher H, Yin Q, Kennedy MJ, Shen J. Sci Adv. 2023 Feb 22;9(8):eade2540. doi: 10.1126/sciadv.ade2540. Epub 2023 Feb 22. PubMed |
| A Novel CCK Receptor GPR173 Mediates Potentiation of GABAergic Inhibition. He L, Shi H, Zhang G, Peng Y, Ghosh A, Zhang M, Hu X, Liu C, Shao Y, Wang S, Chen L, Sun W, Su J, Chen X, Zhang L, Chan YS, Pei D, Tortorella M, Guo Y, Yan H, He J. J Neurosci. 2023 Mar 29;43(13):2305-2325. doi: 10.1523/JNEUROSCI.2035-22.2023. Epub 2023 Feb 22. PubMed |
| CD40 signal rewires fatty acid and glutamine metabolism for stimulating macrophage anti-tumorigenic functions. Liu PS, Chen YT, Li X, Hsueh PC, Tzeng SF, Chen H, Shi PZ, Xie X, Parik S, Planque M, Fendt SM, Ho PC. Nat Immunol. 2023 Mar;24(3):452-462. doi: 10.1038/s41590-023-01430-3. Epub 2023 Feb 23. PubMed |
| Lymphocyte activation gene 3 (Lag3) supports Foxp3 (+) Treg cell function by restraining c-Myc-dependent aerobic glycolysis. Kim D, Kim G, Yu R, Lee J, Kim S, Qiu K, Montauti E, Fang D, Chandel NS, Choi J, Min B. bioRxiv. 2023 Feb 13:2023.02.13.528371. doi: 10.1101/2023.02.13.528371. Preprint. PubMed |
| 3D Microcapsules for Human Bone Marrow Derived Mesenchymal Stem Cell Biomanufacturing in a Vertical-Wheel Bioreactor. Teryek M, Jadhav P, Bento R, Parekkadan B. bioRxiv. 2023 Feb 16:2023.02.16.528656. doi: 10.1101/2023.02.16.528656. Preprint. PubMed |
| Network-based elucidation of colon cancer drug resistance by phosphoproteomic time-series analysis. Rosenberger G, Li W, Turunen M, He J, Subramaniam PS, Pampou S, Griffin AT, Karan C, Kerwin P, Murray D, Honig B, Liu Y, Califano A. bioRxiv. 2023 Feb 16:2023.02.15.528736. doi: 10.1101/2023.02.15.528736. Preprint. PubMed |
| C9orf72 poly(PR) mediated neurodegeneration is associated with nucleolar stress. Cicardi ME, Hallgren JH, Mawrie D, Krishnamurthy K, Markandaiah SS, Nelson AT, Kankate V, Anderson EN, Pasinelli P, Pandey UB, Eischen CM, Trotti D. bioRxiv. 2023 Feb 16:2023.02.16.528809. doi: 10.1101/2023.02.16.528809. Preprint. PubMed |
| Intracellular replication of Pseudomonas aeruginosa in epithelial cells requires suppression of the caspase-4 inflammasome. Kroken AR, Klein KA, Mitchell PS, Nieto V, Jedel EJ, Evans DJ, Fleiszig SMJ. bioRxiv. 2023 Apr 28:2023.02.13.528260. doi: 10.1101/2023.02.13.528260. Preprint. PubMed |
| EVL and MIM/MTSS1 regulate actin cytoskeletal remodeling to promote dendritic filopodia in neurons. Parker SS, Ly KT, Grant AD, Sweetland J, Wang AM, Parker JD, Roman MR, Saboda K, Roe DJ, Padi M, Wolgemuth CW, Langlais P, Mouneimne G. J Cell Biol. 2023 May 1;222(5):e202106081. doi: 10.1083/jcb.202106081. Epub 2023 Feb 24. PubMed |
| Evaluation of CAR-T Cells' Cytotoxicity against Modified Solid Tumor Cell Lines. Valiullina AK, Zmievskaya EA, Ganeeva IA, Zhuravleva MN, Garanina EE, Rizvanov AA, Petukhov AV, Bulatov ER. Biomedicines. 2023 Feb 19;11(2):626. doi: 10.3390/biomedicines11020626. PubMed |
| NADK-mediated de novo NADP(H) synthesis is a metabolic adaptation essential for breast cancer metastasis. Ilter D, Drapela S, Schild T, Ward NP, Adhikari E, Low V, Asara J, Oskarsson T, Lau EK, DeNicola GM, McReynolds MR, Gomes AP. Redox Biol. 2023 May;61:102627. doi: 10.1016/j.redox.2023.102627. Epub 2023 Feb 9. PubMed |
| BdLT-Seq as a barcode decay-based method to unravel lineage-linked transcriptome plasticity. Shlyakhtina Y, Bloechl B, Portal MM. Nat Commun. 2023 Feb 25;14(1):1085. doi: 10.1038/s41467-023-36744-1. PubMed |
| Translational landscape in human early neural fate determination. Yan C, Meng Y, Yang J, Chen J, Jiang W. Development. 2023 Mar 15;150(6):dev201177. doi: 10.1242/dev.201177. Epub 2023 Mar 15. PubMed |
| Three-dimensional growth reveals fine-tuning of 5-lipoxygenase by proliferative pathways in cancer. Gobel T, Goebel B, Hyprath M, Lamminger I, Weisser H, Angioni C, Mathes M, Thomas D, Kahnt AS. Life Sci Alliance. 2023 Feb 27;6(5):e202201804. doi: 10.26508/lsa.202201804. Print 2023 May. PubMed |
| Integrative analysis of bulk and single-cell gene expression profiles to identify tumor-associated macrophage-derived CCL18 as a therapeutic target of esophageal squamous cell carcinoma. Sui X, Chen C, Zhou X, Wen X, Shi C, Chen G, Liu J, He Z, Yao Y, Li Y, Gao Y. J Exp Clin Cancer Res. 2023 Feb 27;42(1):51. doi: 10.1186/s13046-023-02612-5. PubMed |
| CAR-T Cells with Phytohemagglutinin (PHA) Provide Anti-Cancer Capacity with Better Proliferation, Rejuvenated Effector Memory, and Reduced Exhausted T Cell Frequencies. Gulden G, Sert B, Teymur T, Ay Y, Tiryaki NN, Mishra AK, Ovali E, Tarhan N, Tastan C. Vaccines (Basel). 2023 Jan 31;11(2):313. doi: 10.3390/vaccines11020313. PubMed |
| Comparison of a Genotype 1 and a Genotype 2 Macaque Foamy Virus env Gene Indicates Distinct Infectivity and Cell-Cell Fusion but Similar Tropism and Restriction of Cell Entry by Interferon-Induced Transmembrane Proteins. Fricke T, Schlagowski S, Liu S, Yang X, Fiebig U, Kaul A, Ensser A, Hahn AS. Viruses. 2023 Jan 17;15(2):262. doi: 10.3390/v15020262. PubMed |
| Euphejolkinolide A, a new ent-abietane lactone from Euphorbia peplus L. with promising biological activity in activating the autophagy-lysosomal pathway. Ran X, Lu QY, Li YY, Pu XX, Guo Y, Yuan MR, Guan SP, Sun M, Jiao L, Yao YG, Di YT, Hao XJ, Luo R. Heliyon. 2023 Feb 13;9(2):e13691. doi: 10.1016/j.heliyon.2023.e13691. eCollection 2023 Feb. PubMed |
| Identification of the mouse Kupffer cell receptors recognizing pneumococcal capsules by affinity screening. An H, Tian X, Huang Y, Zhang JR. STAR Protoc. 2023 Mar 17;4(1):102065. doi: 10.1016/j.xpro.2023.102065. Epub 2023 Jan 24. PubMed |
| CRISPR-based large-scale modeling of loss-of-function mutations to investigate mechanisms of stress resistance in cancer. Simeoni F, Loukas I, Wilson TS, Scaffidi P. STAR Protoc. 2023 Feb 11;4(1):102097. doi: 10.1016/j.xpro.2023.102097. PubMed |
| Production of CRISPRi-engineered primary human mammary epithelial cells with baboon envelope pseudotyped lentiviral vectors. Pastor S, Wicinski J, Charafe-Jauffret E, Verhoeyen E, Guittard G, Ginestier C. STAR Protoc. 2023 Jan 19;4(1):102055. doi: 10.1016/j.xpro.2023.102055. PubMed |
| The long-range interaction between two GNAS imprinting control regions delineates pseudohypoparathyroidism type 1B pathogenesis. Iwasaki Y, Aksu C, Reyes M, Ay B, He Q, Bastepe M. J Clin Invest. 2023 Apr 17;133(8):e167953. doi: 10.1172/JCI167953. PubMed |
| Localization of Kif1c mRNA to cell protrusions dictates binding partner specificity of the encoded protein. Norris ML, Mendell JT. Genes Dev. 2023 Mar 1;37(5-6):191-203. doi: 10.1101/gad.350320.122. Epub 2023 Mar 1. PubMed |
| RTP4 silencing provokes tumor-intrinsic resistance to immune checkpoint blockade in colorectal cancer. Yamamoto Y, Shimada S, Akiyama Y, Tsukihara S, Sugimoto R, Kabashima A, Tokunaga M, Kinugasa Y, Kawakami Y, Tanaka S. J Gastroenterol. 2023 Jun;58(6):540-553. doi: 10.1007/s00535-023-01969-w. Epub 2023 Mar 2. PubMed |
| Ependymal polarity defects coupled with disorganized ciliary beating drive abnormal cerebrospinal fluid flow and spine curvature in zebrafish. Xie H, Kang Y, Liu J, Huang M, Dai Z, Shi J, Wang S, Li L, Li Y, Zheng P, Sun Y, Han Q, Zhang J, Zhu Z, Xu L, Yelick PC, Cao M, Zhao C. PLoS Biol. 2023 Mar 2;21(3):e3002008. doi: 10.1371/journal.pbio.3002008. eCollection 2023 Mar. PubMed |
| P-selectin-targeted nanocarriers induce active crossing of the blood-brain barrier via caveolin-1-dependent transcytosis. Tylawsky DE, Kiguchi H, Vaynshteyn J, Gerwin J, Shah J, Islam T, Boyer JA, Boue DR, Snuderl M, Greenblatt MB, Shamay Y, Raju GP, Heller DA. Nat Mater. 2023 Mar;22(3):391-399. doi: 10.1038/s41563-023-01481-9. Epub 2023 Mar 2. PubMed |
| Endogenous retrovirus-derived enhancers confer the transcriptional regulation of human trophoblast syncytialization. Yu M, Hu X, Pan Z, Du C, Jiang J, Zheng W, Cai H, Wang Y, Deng W, Wang H, Lu J, Sun MA, Cao B. Nucleic Acids Res. 2023 Jun 9;51(10):4745-4759. doi: 10.1093/nar/gkad109. PubMed |
| Arf6 Regulates Endocytosis and Angiogenesis by Promoting Filamentous Actin Assembly. Francis CR, Bell ML, Skripnichuk MM, Kushner EJ. bioRxiv. 2023 Feb 22:2023.02.22.529543. doi: 10.1101/2023.02.22.529543. Preprint. PubMed |
| Candida albicans stimulates the formation of a multi-receptor complex that mediates epithelial cell invasion during oropharyngeal infection. Phan QT, Solis NV, Cravener MV, Swidergall M, Lin J, Huang MY, Liu H, Singh S, Ibrahim AS, Mazzone M, Mitchell AP, Filler SG. bioRxiv. 2023 Feb 23:2023.02.23.529756. doi: 10.1101/2023.02.23.529756. Preprint. PubMed |
| An autoimmune pleiotropic SNP modulates IRF5 alternative promoter usage through ZBTB3-mediated chromatin looping. Wang Z, Liang Q, Qian X, Hu B, Zheng Z, Wang J, Hu Y, Bao Z, Zhao K, Zhou Y, Feng X, Yi X, Li J, Shi J, Liu Z, Hao J, Chen K, Yu Y, Sham PC, Lu W, Wang X, Song W, Li MJ. Nat Commun. 2023 Mar 3;14(1):1208. doi: 10.1038/s41467-023-36897-z. PubMed |
| CRISPR/Cas9 mediated specific ablation of vegfa in retinal pigment epithelium efficiently regresses choroidal neovascularization. Park J, Cui G, Lee H, Jeong H, Kwak JJ, Lee J, Byeon SH. Sci Rep. 2023 Mar 6;13(1):3715. doi: 10.1038/s41598-023-29014-z. PubMed |
| C4orf19 inhibits colorectal cancer cell proliferation by competitively binding to Keap1 with TRIM25 via the USP17/Elk-1/CDK6 axis. Huang S, Li J, Wu S, Zheng Z, Wang C, Li H, Zhao L, Zhang X, Huang H, Huang C, Xie Q. Oncogene. 2023 Apr;42(17):1333-1346. doi: 10.1038/s41388-023-02656-z. Epub 2023 Mar 7. PubMed |
| TRIM28 promotes luminal cell plasticity in a mouse model of prostate cancer. Yende AS, Williams EC, Pletcher A, Helfand A, Ibeawuchi H, North TM, Latham PS, Horvath A, Shibata M. Oncogene. 2023 Apr;42(17):1347-1359. doi: 10.1038/s41388-023-02655-0. Epub 2023 Mar 8. PubMed |
| The DNA damage response pathway regulates the expression of the immune checkpoint CD47. Ghantous L, Volman Y, Hefez R, Wald O, Stern E, Friehmann T, Chajut A, Bremer E, Elhalel MD, Rachmilewitz J. Commun Biol. 2023 Mar 7;6(1):245. doi: 10.1038/s42003-023-04615-6. PubMed |
| Fumarate induces vesicular release of mtDNA to drive innate immunity. Zecchini V, Paupe V, Herranz-Montoya I, Janssen J, Wortel IMN, Morris JL, Ferguson A, Chowdury SR, Segarra-Mondejar M, Costa ASH, Pereira GC, Tronci L, Young T, Nikitopoulou E, Yang M, Bihary D, Caicci F, Nagashima S, Speed A, Bokea K, Baig Z, Samarajiwa S, Tran M, Mitchell T, Johnson M, Prudent J, Frezza C. Nature. 2023 Mar;615(7952):499-506. doi: 10.1038/s41586-023-05770-w. Epub 2023 Mar 8. PubMed |
| Structure of the Wnt-Frizzled-LRP6 initiation complex reveals the basis for coreceptor discrimination. Tsutsumi N, Hwang S, Waghray D, Hansen S, Jude KM, Wang N, Miao Y, Glassman CR, Caveney NA, Janda CY, Hannoush RN, Garcia KC. Proc Natl Acad Sci U S A. 2023 Mar 14;120(11):e2218238120. doi: 10.1073/pnas.2218238120. Epub 2023 Mar 9. PubMed |
| PVT1 inhibition stimulates anti-tumor immunity, prevents metastasis, and depletes cancer stem cells in squamous cell carcinoma. Qin Z, Zhang W, Liu S, Wang Y, Peng X, Jia L. Cell Death Dis. 2023 Mar 9;14(3):187. doi: 10.1038/s41419-023-05710-6. PubMed |
| PP6 regulation of Aurora A-TPX2 limits NDC80 phosphorylation and mitotic spindle size. Sobajima T, Kowalczyk KM, Skylakakis S, Hayward D, Fulcher LJ, Neary C, Batley C, Kurlekar S, Roberts E, Gruneberg U, Barr FA. J Cell Biol. 2023 May 1;222(5):e202205117. doi: 10.1083/jcb.202205117. Epub 2023 Mar 10. PubMed |
| FAM193A is a positive regulator of p53 activity. Szwarc MM, Guarnieri AL, Joshi M, Duc HN, Laird MC, Pandey A, Khanal S, Dohm E, Bui AK, Sullivan KD, Galbraith MD, Andrysik Z, Espinosa JM. Cell Rep. 2023 Mar 28;42(3):112230. doi: 10.1016/j.celrep.2023.112230. Epub 2023 Mar 9. PubMed |
| Silencing LCN2 suppresses oral squamous cell carcinoma progression by reducing EGFR signal activation and recycling. Huang Z, Rui X, Yi C, Chen Y, Chen R, Liang Y, Wang Y, Yao W, Xu X, Huang Z. J Exp Clin Cancer Res. 2023 Mar 11;42(1):60. doi: 10.1186/s13046-023-02618-z. PubMed |
| USP15 Represses Hepatocellular Carcinoma Progression by Regulation of Pathways of Cell Proliferation and Cell Migration: A System Biology Analysis. Ren Y, Song Z, Rieser J, Ackermann J, Koch I, Lv X, Ji T, Cai X. Cancers (Basel). 2023 Feb 21;15(5):1371. doi: 10.3390/cancers15051371. PubMed |
| Inhibition of RNA Polymerase III Augments the Anti-Cancer Properties of TNFalpha. Nair HG, Jurkiewicz A, Graczyk D. Cancers (Basel). 2023 Feb 27;15(5):1495. doi: 10.3390/cancers15051495. PubMed |
| 5-Fluorouracil Suppresses Colon Tumor through Activating the p53-Fas Pathway to Sensitize Myeloid-Derived Suppressor Cells to FasL(+) Cytotoxic T Lymphocyte Cytotoxicity. Yang Y, Zhang M, Zhang Y, Liu K, Lu C. Cancers (Basel). 2023 Mar 2;15(5):1563. doi: 10.3390/cancers15051563. PubMed |
| Isolation of Cells from Glioblastoma Multiforme Grade 4 Tumors for Infection with Zika Virus prME and ME Pseudotyped HIV-1. Pohlking C, Beier S, Formanski JP, Friese M, Schreiber M, Schwalbe B. Int J Mol Sci. 2023 Feb 24;24(5):4467. doi: 10.3390/ijms24054467. PubMed |
| Chemotherapeutic drugs elicit stemness and metabolic alteration to mediate acquired drug-resistant phenotype in acute myeloid leukemia cell lines. Illangeswaran RSS, Jebanesan DZP, Sivakumar KK, Vidhyadharan RT, Rajamani BM, Janet NB, David E, Velayudhan SR, Mathews V, Balasubramanian P. Leuk Res. 2023 May;128:107054. doi: 10.1016/j.leukres.2023.107054. Epub 2023 Mar 3. PubMed |
| Pretraining strategies for effective promoter-driven gene expression prediction. Reddy AJ, Herschl MH, Kolli S, Lu AX, Geng X, Kumar A, Hsu PD, Levine S, Ioannidis NM. bioRxiv. 2023 Feb 27:2023.02.24.529941. doi: 10.1101/2023.02.24.529941. Preprint. PubMed |
| A lncRNA identifies Irf8 enhancer element in negative feedback control of dendritic cell differentiation. Xu H, Li Z, Kuo CC, Gotz K, Look T, de Toledo MAS, Sere K, Costa IG, Zenke M. Elife. 2023 Mar 14;12:e83342. doi: 10.7554/eLife.83342. PubMed |
| Incorporating a Polyethyleneglycol Linker to Enhance the Hydrophilicity of Mitochondria-Targeted Triphenylphosphonium Constructs. Uno S, Harkiss AH, Chowdhury R, Caldwell ST, Prime TA, James AM, Gallagher B, Prudent J, Hartley RC, Murphy MP. Chembiochem. 2023 Jun 1;24(11):e202200774. doi: 10.1002/cbic.202200774. Epub 2023 May 4. PubMed |
| A multi-organoid platform identifies CIART as a key factor for SARS-CoV-2 infection. Tang X, Xue D, Zhang T, Nilsson-Payant BE, Carrau L, Duan X, Gordillo M, Tan AY, Qiu Y, Xiang J, Schwartz RE, tenOever BR, Evans T, Chen S. Nat Cell Biol. 2023 Mar;25(3):381-389. doi: 10.1038/s41556-023-01095-y. Epub 2023 Mar 13. PubMed |
| Guanylate-binding protein 1 inhibits nuclear delivery of pseudorabies virus by disrupting structure of actin filaments. Zhang X, Du Q, Chen G, Jiang Y, Huang K, Li L, Tong D, Huang Y. Vet Res. 2023 Mar 14;54(1):21. doi: 10.1186/s13567-023-01154-0. PubMed |
Participation of ATM, SMG1, and DDX5 in a DNA Damage-Induced Alternative Splicing Pathway.
McCann JJ, Fleenor DE, Chen J, Lai CH, Bass TE, Kastan MB.
Radiat Res. 2023 Apr 1;199(4):406-421. doi: 10.1667/RADE-22-00219.1.
PubMed
Associated Plasmids |
Identifying constitutive and context-specific molecular-tension-sensitive protein recruitment within focal adhesions.
Tao A, LaCroix AS, Shoyer TC, Venkatraman V, Xu KL, Feiger B, Hoffman BD.
Dev Cell. 2023 Mar 10:S1534-5807(23)00074-6. doi: 10.1016/j.devcel.2023.02.015.
PubMed
Associated Plasmids |
| Excessive transcription-replication conflicts are a vulnerability of BRCA1-mutant cancers. Patel PS, Algouneh A, Krishnan R, Reynolds JJ, Nixon KCJ, Hao J, Lee J, Feng Y, Fozil C, Stanic M, Yerlici T, Su P, Soares F, Liedtke E, Prive G, Baider GD, Pujana MA, Mekhail K, He HH, Hakem A, Stewart GS, Hakem R. Nucleic Acids Res. 2023 May 22;51(9):4341-4362. doi: 10.1093/nar/gkad172. PubMed |
| 4E-BP1 counteracts human mesenchymal stem cell senescence via maintaining mitochondrial homeostasis. He Y, Ji Q, Wu Z, Cai Y, Yin J, Zhang Y, Zhang S, Liu X, Zhang W, Liu GH, Wang S, Song M, Qu J. Protein Cell. 2023 Apr 13;14(3):202-216. doi: 10.1093/procel/pwac037. PubMed |
| VE-822 upregulates the deubiquitinase OTUD1 to stabilize FHL1 to inhibit the progression of lung adenocarcinoma. Zhang Q, Li J, Chen Z, Jiang K, Yang K, Huang F, Huang A, Zhang X, Zhang J, Wang H. Cell Oncol (Dordr). 2023 Aug;46(4):1001-1014. doi: 10.1007/s13402-023-00793-x. Epub 2023 Mar 16. PubMed |
| Activation of Hippo Pathway Damages Slit Diaphragm by Deprivation of Ajuba Proteins. Gilhaus K, Cepok C, Kamm D, Surmann B, Nedvetsky PI, Emich J, Sundukova A, Saatkamp K, Nusse H, Klingauf J, Wennmann DO, George B, Krahn MP, Pavenstadt HJ, Vollenbroker BA. J Am Soc Nephrol. 2023 Jun 1;34(6):1039-1055. doi: 10.1681/ASN.0000000000000107. Epub 2023 Mar 16. PubMed |
| HDAC3 is critical in tumor development and therapeutic resistance in Kras-mutant non-small cell lung cancer. Eichner LJ, Curtis SD, Brun SN, McGuire CK, Gushterova I, Baumgart JT, Trefts E, Ross DS, Rymoff TJ, Shaw RJ. Sci Adv. 2023 Mar 15;9(11):eadd3243. doi: 10.1126/sciadv.add3243. Epub 2023 Mar 17. PubMed |
| Endogenous but not sensory-driven activity controls migration, morphogenesis and survival of adult-born juxtaglomerular neurons in the mouse olfactory bulb. Li K, Figarella K, Su X, Kovalchuk Y, Gorzolka J, Neher JJ, Mojtahedi N, Casadei N, Hedrich UBS, Garaschuk O. Cell Mol Life Sci. 2023 Mar 18;80(4):98. doi: 10.1007/s00018-023-04753-4. PubMed |
| Honokiol acts as an AMPK complex agonist therapeutic in non-alcoholic fatty liver disease and metabolic syndrome. Tian R, Yang J, Wang X, Liu S, Dong R, Wang Z, Yang Z, Zhang Y, Cai Z, Yang H, Hu Y, She ZG, Li H, Zhou J, Zhang XJ. Chin Med. 2023 Mar 17;18(1):30. doi: 10.1186/s13020-023-00729-5. PubMed |
| Single-cell transcriptomic atlas of mouse cochlear aging. Sun G, Zheng Y, Fu X, Zhang W, Ren J, Ma S, Sun S, He X, Wang Q, Ji Z, Cheng F, Yan K, Liu Z, Belmonte JCI, Qu J, Wang S, Chai R, Liu GH. Protein Cell. 2023 Apr 13;14(3):180-201. doi: 10.1093/procel/pwac058. PubMed |
| The vascular gene Apold1 is dispensable for normal development but controls angiogenesis under pathological conditions. Fan Z, Ardicoglu R, Batavia AA, Rust R, von Ziegler L, Waag R, Zhang J, Desgeorges T, Sturman O, Dang H, Weber R, Roszkowski M, Moor AE, Schwab ME, Germain PL, Bohacek J, De Bock K. Angiogenesis. 2023 Aug;26(3):385-407. doi: 10.1007/s10456-023-09870-z. Epub 2023 Mar 18. PubMed |
| DNMT3A low-expression is correlated to poor prognosis in childhood B-ALL and confers resistance to daunorubicin on leukemic cells. Li W, Liu S, Wang C, Cui L, Zhao X, Liu W, Zhang R, Li Z. BMC Cancer. 2023 Mar 18;23(1):255. doi: 10.1186/s12885-023-10724-6. PubMed |
| High-capacity adenovector delivery of forced CRISPR-Cas9 heterodimers fosters precise chromosomal deletions in human cells. Tasca F, Brescia M, Liu J, Janssen JM, Mamchaoui K, Goncalves MAFV. Mol Ther Nucleic Acids. 2023 Feb 22;31:746-762. doi: 10.1016/j.omtn.2023.02.025. eCollection 2023 Mar 14. PubMed |
| A new method to synthesize multiple gRNA libraries and functional mapping of mammalian H3K4me3 regions. Pan C, Li R, Shui L, Xiao Z, Wang Y, Zhu J, Wu C, Zhang L, Jia J, Zheng M. Nucleic Acids Res. 2023 May 22;51(9):e50. doi: 10.1093/nar/gkad198. PubMed |
| BCL7A is silenced by hypermethylation to promote acute myeloid leukemia. Patino-Mercau JR, Balinas-Gavira C, Andrades A, Benitez-Cantos MS, Rot AE, Rodriguez MI, Alvarez-Perez JC, Cuadros M, Medina PP. Biomark Res. 2023 Mar 20;11(1):32. doi: 10.1186/s40364-023-00472-x. PubMed |
| TCF1/LEF1 triggers Wnt-dependent chemokine/cytokine-induced inflammation and cadherin pathways to drive T-ALL cell migration. Zhao P, Sun L, Zhao C. Biochem Biophys Rep. 2023 Mar 12;34:101457. doi: 10.1016/j.bbrep.2023.101457. eCollection 2023 Jul. PubMed |
| Massively parallel characterization of transcriptional regulatory elements in three diverse human cell types. Agarwal V, Inoue F, Schubach M, Martin BK, Dash PM, Zhang Z, Sohota A, Noble WS, Yardimci GG, Kircher M, Shendure J, Ahituv N. bioRxiv. 2023 Mar 6:2023.03.05.531189. doi: 10.1101/2023.03.05.531189. Preprint. PubMed |
| Dynamics of Chromatin Accessibility During Hematopoietic Stem Cell Differentiation Into Progressively Lineage-Committed Progeny. Martin EW, Rodriguez Y Baena A, Reggiardo RE, Worthington AK, Mattingly CS, Poscablo DM, Krietsch J, McManus MT, Carpenter S, Kim DH, Forsberg EC. Stem Cells. 2023 May 15;41(5):520-539. doi: 10.1093/stmcls/sxad022. PubMed |
| RBFOX2 modulates a metastatic signature of alternative splicing in pancreatic cancer. Jbara A, Lin KT, Stossel C, Siegfried Z, Shqerat H, Amar-Schwartz A, Elyada E, Mogilevsky M, Raitses-Gurevich M, Johnson JL, Yaron TM, Ovadia O, Jang GH, Danan-Gotthold M, Cantley LC, Levanon EY, Gallinger S, Krainer AR, Golan T, Karni R. Nature. 2023 May;617(7959):147-153. doi: 10.1038/s41586-023-05820-3. Epub 2023 Mar 22. PubMed |
| LncRNA HHIP-AS1 suppresses lung squamous cell carcinoma by stabilizing HHIP mRNA. Hu Z, Liu Y, Tang J, Luo R, Qin J, Mo Z, Xie J, Jiang X, Wei S, Lin C. Life Sci. 2023 May 15;321:121578. doi: 10.1016/j.lfs.2023.121578. Epub 2023 Mar 21. PubMed |
| Thymidine nucleotide metabolism controls human telomere length. Mannherz W, Agarwal S. Nat Genet. 2023 Apr;55(4):568-580. doi: 10.1038/s41588-023-01339-5. Epub 2023 Mar 23. PubMed |
| Arginine shortage induces replication stress and confers genotoxic resistance by inhibiting histone H4 translation and promoting PCNA ubiquitination. Wang YC, Kelso AA, Karamafrooz A, Chen YH, Chen WK, Cheng CT, Qi Y, Gu L, Malkas L, Taglialatela A, Kung HJ, Moldovan GL, Ciccia A, Stark JM, Ann DK. Cell Rep. 2023 Apr 25;42(4):112296. doi: 10.1016/j.celrep.2023.112296. Epub 2023 Mar 23. PubMed |
| Transcriptional activation of endogenous Oct4 via the CRISPR/dCas9 activator ameliorates Hutchinson-Gilford progeria syndrome in mice. Kim J, Hwang Y, Kim S, Chang Y, Kim Y, Kwon Y, Kim J. Aging Cell. 2023 Jun;22(6):e13825. doi: 10.1111/acel.13825. Epub 2023 Mar 25. PubMed |
| An actin filament branching surveillance system regulates cell cycle progression, cytokinesis and primary ciliogenesis. Cao M, Zou X, Li C, Lin Z, Wang N, Zou Z, Ye Y, Seemann J, Levine B, Tang Z, Zhong Q. Nat Commun. 2023 Mar 27;14(1):1687. doi: 10.1038/s41467-023-37340-z. PubMed |
| Disruption of the MYC Superenhancer Complex by Dual Targeting of FLT3 and LSD1 in Acute Myeloid Leukemia. Yashar WM, Curtiss BM, Coleman DJ, VanCampen J, Kong G, Macaraeg J, Estabrook J, Demir E, Long N, Bottomly D, McWeeney SK, Tyner JW, Druker BJ, Maxson JE, Braun TP. Mol Cancer Res. 2023 Jul 5;21(7):631-647. doi: 10.1158/1541-7786.MCR-22-0745. PubMed |
| Alpha 2-macroglobulin acts as a clearance factor in the lysosomal degradation of extracellular misfolded proteins. Tomihari A, Kiyota M, Matsuura A, Itakura E. Sci Rep. 2023 Mar 28;13(1):4680. doi: 10.1038/s41598-023-31104-x. PubMed |
| Inactivation of SARS-CoV-2 on Surfaces by Cold-Plasma-Generated Reactive Species. Thomas SV, Dienger-Stambaugh K, Jordan M, Wang Y, Hammonds J, Spearman P, Shi D. Bioengineering (Basel). 2023 Feb 21;10(3):280. doi: 10.3390/bioengineering10030280. PubMed |
| Importance of ACE2 for SARS-CoV-2 Infection of Kidney Cells. Kroll MK, Schloer S, Candan P, Korthals N, Wenzel C, Ihle H, Gilhaus K, Liedtke KR, Schofbanker M, Surmann B, Schroter R, Neugebauer U, Mall G, Oswald S, Ludwig S, Rescher U, Vollenbroker B, Ciarimboli G. Biomolecules. 2023 Mar 3;13(3):472. doi: 10.3390/biom13030472. PubMed |
| MYCN Amplification, along with Wild-Type RB1 Expression, Enhances CDK4/6 Inhibitors' Efficacy in Neuroblastoma Cells. De Rosa P, Severi F, Zadran SK, Russo M, Aloisi S, Rigamonti A, Capranico G, Milazzo G, Perini G. Int J Mol Sci. 2023 Mar 12;24(6):5408. doi: 10.3390/ijms24065408. PubMed |
CRISPR screens identify gene targets at breast cancer risk loci.
Tuano NK, Beesley J, Manning M, Shi W, Perlaza-Jimenez L, Malaver-Ortega LF, Paynter JM, Black D, Civitarese A, McCue K, Hatzipantelis A, Hillman K, Kaufmann S, Sivakumaran H, Polo JM, Reddel RR, Band V, French JD, Edwards SL, Powell DR, Chenevix-Trench G, Rosenbluh J.
Genome Biol. 2023 Mar 29;24(1):59. doi: 10.1186/s13059-023-02898-w.
PubMed
Associated Plasmids |
| Deep Mutational Scanning to Predict Escape from Bebtelovimab in SARS-CoV-2 Omicron Subvariants. Alcantara MC, Higuchi Y, Kirita Y, Matoba S, Hoshino A. Vaccines (Basel). 2023 Mar 22;11(3):711. doi: 10.3390/vaccines11030711. PubMed |
| Primate TRIM34 is a broadly-acting, TRIM5-dependent lentiviral restriction factor. Twentyman J, Khalifeh A, Felton AL, Emerman M, OhAinle M. bioRxiv. 2023 Mar 25:2023.03.24.534139. doi: 10.1101/2023.03.24.534139. Preprint. PubMed |
| Long noncoding RNA Malat1 inhibits Tead3-Nfatc1-mediated osteoclastogenesis to suppress osteoporosis and bone metastasis. Zhao Y, Teng H, Deng Y, Sheldon M, Martinez C, Zhang J, Tian A, Sun Y, Nakagawa S, Yao F, Wang H, Ma L. Res Sq. 2023 Mar 20:rs.3.rs-2405644. doi: 10.21203/rs.3.rs-2405644/v1. Preprint. PubMed |
| Mitigation of chromosome loss in clinical CRISPR-Cas9-engineered T cells. Tsuchida CA, Brandes N, Bueno R, Trinidad M, Mazumder T, Yu B, Hwang B, Chang C, Liu J, Sun Y, Hopkins CR, Parker KR, Qi Y, Satpathy AT, Stadtmauer EA, Cate JHD, Eyquem J, Fraietta JA, June CH, Chang HY, Ye CJ, Doudna JA. bioRxiv. 2023 Mar 22:2023.03.22.533709. doi: 10.1101/2023.03.22.533709. Preprint. PubMed |
| Genomic transcription factor binding site selection is edited by the chromatin remodeling factor CHD4. Takaku M, Saotome M, Poduval D, Grimm S, Nagornyuk A, Gunarathna S, Shimbo T, Wade P. Res Sq. 2023 Mar 15:rs.3.rs-2587918. doi: 10.21203/rs.3.rs-2587918/v1. Preprint. PubMed |
| Role of GD2 and its biosynthetic enzyme GD3 synthase in prostate cancer tumorigenesis. Bhat AM, Mohapatra BC, Luan H, Mushtaq I, Chakraborty S, Dutta S, Stock MD, Meza JL, Lele SM, Lin MF, Cook LM, Corey E, Morrissey C, Coulter DW, Rowley J, Datta K, Band V, Band H. bioRxiv. 2023 Apr 22:2023.03.18.533299. doi: 10.1101/2023.03.18.533299. Preprint. PubMed |
| Guide-specific loss of efficiency and off-target reduction with Cas9 variants. Zhang L, He W, Fu R, Xu H. bioRxiv. 2023 Mar 16:2023.03.16.532856. doi: 10.1101/2023.03.16.532856. Preprint. PubMed |
| Curved adhesions mediate cell attachment to soft matrix fibres in 3D. Zhang W, Lu CH, Nakamoto ML, Tsai CT, Roy AR, Lee CE, Yang Y, Jahed Z, Li X, Cui B. bioRxiv. 2023 Mar 19:2023.03.16.532975. doi: 10.1101/2023.03.16.532975. Preprint. PubMed |
| The ER membrane protein complex governs lysosomal turnover of a mitochondrial tail-anchored protein, BNIP3, to restrict mitophagy. Delgado JM, Wallace Shepard L, Lamson SW, Liu SL, Shoemaker CJ. bioRxiv [Preprint]. 2023 Mar 24:2023.03.22.533681. doi: 10.1101/2023.03.22.533681. PubMed |
| RTF2 controls replication repriming and ribonucleotide excision at the replisome. Conti BA, Ruiz PD, Broton C, Blobel NJ, Kottemann MC, Sridhar S, Lach FP, Wiley T, Sasi NK, Carroll T, Smogorzewska A. bioRxiv. 2023 Mar 13:2023.03.13.532415. doi: 10.1101/2023.03.13.532415. Preprint. PubMed |
| Activity-dependent subcellular compartmentalization of dendritic mitochondria structure in CA1 pyramidal neurons. Virga DM, Hamilton S, Osei B, Morgan A, Zamponi E, Park NJ, Hewitt VL, Zhang D, Gonzalez KC, Bloss E, Polleux F, Lewis TL. bioRxiv. 2023 Mar 26:2023.03.25.534233. doi: 10.1101/2023.03.25.534233. Preprint. PubMed |
| Shared gene targets of the ATF4 and p53 transcriptional networks. Baniulyte G, Durham SA, Merchant LE, Sammons MA. bioRxiv. 2023 Jun 5:2023.03.15.532778. doi: 10.1101/2023.03.15.532778. Preprint. PubMed |
| ZCCHC17 modulates neuronal RNA splicing and supports cognitive resilience in Alzheimer's disease. Bartosch AMW, Youth EHH, Hansen S, Kaufman ME, Xiao H, Koo SY, Ashok A, Sivakumar S, Soni RK, Dumitrescu LC, Lam TG, Ropri AS, Lee AJ, Klein HU, Vardarajan BN, Bennett DA, Young-Pearse TL, De Jager PL, Hohman TJ, Sproul AA, Teich AF. bioRxiv. 2023 Mar 21:2023.03.21.533654. doi: 10.1101/2023.03.21.533654. Preprint. PubMed |
| Cancer-derived mutation in the OGA stalk domain promotes cell malignancy through dysregulating PDLIM7 and p53. Hu CW, Wang A, Fan D, Worth M, Chen Z, Huang J, Xie J, Macdonald J, Li L, Jiang J. Res Sq [Preprint]. 2023 Mar 20:rs.3.rs-2709128. doi: 10.21203/rs.3.rs-2709128/v1. PubMed |
Overexpression screen of chromosome 21 genes reveals modulators of Sonic hedgehog signaling relevant to Down syndrome.
Moyer AJ, Fernandez FX, Li Y, Klinedinst DK, Florea LD, Kazuki Y, Oshimura M, Reeves RH.
Dis Model Mech. 2023 Apr 1;16(4):dmm049712. doi: 10.1242/dmm.049712. Epub 2023 Apr 13.
PubMed
Associated Plasmids |
Hominoid SVA-lncRNA AK057321 targets human-specific SVA retrotransposons in SCN8A and CDK5RAP2 to initiate neuronal maturation.
Nadler MJS, Chang W, Ozkaynak E, Huo Y, Nong Y, Boillot M, Johnson M, Moreno A, Matthew P Anderson.
Commun Biol. 2023 Mar 30;6(1):347. doi: 10.1038/s42003-023-04683-8.
PubMed
Associated Plasmids |
| RRM2 and CDC6 are novel effectors of XBP1-mediated endocrine resistance and predictive markers of tamoxifen sensitivity. Barua D, Sultana A, Islam MN, Cox F, Gupta A, Gupta S. BMC Cancer. 2023 Mar 30;23(1):288. doi: 10.1186/s12885-023-10745-1. PubMed |
Light-activated macromolecular phase separation modulates transcription by reconfiguring chromatin interactions.
Kim YJ, Lee M Jr, Lee YT, Jing J, Sanders JT, Botten GA, He L, Lyu J, Zhang Y, Mettlen M, Ly P, Zhou Y, Xu J.
Sci Adv. 2023 Mar 31;9(13):eadg1123. doi: 10.1126/sciadv.adg1123. Epub 2023 Mar 31.
PubMed
Associated Plasmids |
| Evolution of Immune Evasion and Host Range Expansion by the SARS-CoV-2 B.1.1.529 (Omicron) Variant. Ren W, Zhang Y, Rao J, Wang Z, Lan J, Liu K, Zhang X, Hu X, Yang C, Zhong G, Zhang R, Wang X, Shan C, Ding Q. mBio. 2023 Apr 25;14(2):e0041623. doi: 10.1128/mbio.00416-23. Epub 2023 Apr 3. PubMed |
| Regulation of human trophoblast gene expression by endogenous retroviruses. Frost JM, Amante SM, Okae H, Jones EM, Ashley B, Lewis RM, Cleal JK, Caley MP, Arima T, Maffucci T, Branco MR. Nat Struct Mol Biol. 2023 Apr;30(4):527-538. doi: 10.1038/s41594-023-00960-6. Epub 2023 Apr 3. PubMed |
| Downregulation of AC092894.1 promotes oxaliplatin resistance in colorectal cancer via the USP3/AR/RASGRP3 axis. Zheng Z, Wu M, Li H, Xu W, Yang M, Pan K, Ni Y, Jiang T, Zheng H, Jin X, Zhang Y, Ding L, Fu J. BMC Med. 2023 Apr 3;21(1):132. doi: 10.1186/s12916-023-02826-6. PubMed |
| Lovastatin inhibits erythroleukemia progression through KLF2-mediated suppression of MAPK/ERK signaling. Gao J, Hu J, Yu F, Wang C, Sheng D, Liu W, Hu A, Yu K, Xiao X, Kuang Y, Zacksenhaus E, Gajendran B, Ben-David Y. BMC Cancer. 2023 Apr 4;23(1):306. doi: 10.1186/s12885-023-10742-4. PubMed |
| AGS3 antagonizes LGN to balance oriented cell divisions and cell fate choices in mammalian epidermis. Descovich CP, Lough KJ, Jena A, Wu JJ, Yom J, Spitzer DC, Uppalapati M, Kedziora KM, Williams SE. Elife. 2023 Apr 5;12:e80403. doi: 10.7554/eLife.80403. PubMed |
| A stress-induced cilium-to-PML-NB route drives senescence initiation. Ma X, Zhang Y, Zhang Y, Zhang X, Huang Y, He K, Chen C, Hao J, Zhao D, LeBrasseur NK, Kirkland JL, Chini EN, Wei Q, Ling K, Hu J. Nat Commun. 2023 Apr 3;14(1):1840. doi: 10.1038/s41467-023-37362-7. PubMed |
| Identification of Ndfip1 as a novel negative regulator for spatial memory formation associated with increased ubiquitination of Beclin 1 and PTEN. Hsu WL, Ma YL, Chen YC, Liu YC, Cheng KM, Lee EHY. PLoS One. 2023 Apr 6;18(4):e0283908. doi: 10.1371/journal.pone.0283908. eCollection 2023. PubMed |
| Targeting HDAC11 activity by FT895 restricts EV71 replication. Xie H, Yang E, Wang C, Peng C, Ji L. Virus Res. 2023 Jun;330:199108. doi: 10.1016/j.virusres.2023.199108. Epub 2023 Apr 15. PubMed |
| Carbon nanotube recognition by human Siglec-14 provokes inflammation. Yamaguchi SI, Xie Q, Ito F, Terao K, Kato Y, Kuroiwa M, Omori S, Taniura H, Kinoshita K, Takahashi T, Toyokuni S, Kasahara K, Nakayama M. Nat Nanotechnol. 2023 Jun;18(6):628-636. doi: 10.1038/s41565-023-01363-w. Epub 2023 Apr 6. PubMed |
| Optimized whole-genome CRISPR interference screens identify ARID1A-dependent growth regulators in human induced pluripotent stem cells. Usluer S, Hallast P, Crepaldi L, Zhou Y, Urgo K, Dincer C, Su J, Noell G, Alasoo K, El Garwany O, Gerety SS, Newman B, Dovey OM, Parts L. Stem Cell Reports. 2023 May 9;18(5):1061-1074. doi: 10.1016/j.stemcr.2023.03.008. Epub 2023 Apr 6. PubMed |
| Suramin binds and inhibits infection of SARS-CoV-2 through both spike protein-heparan sulfate and ACE2 receptor interactions. Kwon PS, Xu S, Oh H, Kwon SJ, Rodrigues AL, Feroz M, Fraser K, He P, Zhang F, Hong JJ, Linhardt RJ, Dordick JS. Commun Biol. 2023 Apr 8;6(1):387. doi: 10.1038/s42003-023-04789-z. PubMed |
| Lentiviral Micro-dystrophin Gene Treatment into Late-stage mdx Mice for Duchenne Muscular Dystrophy Disease. Eren SA, Tastan C, Karadeniz KB, Turan RD, Cakirsoy D, Kancagi DD, Yilmaz SU, Oztatlici M, Oztatlici H, Ozer S, Tumentemur G, Baykal AT, Ovali E. Curr Gene Ther. 2023;23(4):304-315. doi: 10.2174/1566523223666230407091317. PubMed |
| TNF-NFkB-p53 axis restricts in vivo survival of hPSC-derived dopamine neuron. Kim TW, Koo SY, Riessland M, Cho H, Chaudhry F, Kolisnyk B, Russo MV, Saurat N, Mehta S, Garippa R, Betel D, Studer L. bioRxiv. 2023 Mar 31:2023.03.29.534819. doi: 10.1101/2023.03.29.534819. Preprint. PubMed |
| Asparagine starvation suppresses histone demethylation through iron depletion. Jiang J, Srivastava S, Liu S, Seim G, Claude R, Zhong M, Cao S, Dave U, Kapur R, Mosley AL, Zhang C, Wan J, Fan J, Zhang J. iScience. 2023 Mar 16;26(4):106425. doi: 10.1016/j.isci.2023.106425. eCollection 2023 Apr 21. PubMed |
| Targeted therapy for cisplatin-resistant lung cancer via aptamer-guided nano-zinc carriers containing USP14 siRNA. Zhao X, Wu X, Wang H, Lai S, Wang J. MedComm (2020). 2023 Apr 6;4(2):e237. doi: 10.1002/mco2.237. eCollection 2023 Apr. PubMed |
| Targeting SMYD2 inhibits prostate cancer cell growth by regulating c-Myc signaling. Li J, Wan F, Zhang J, Zheng S, Yang Y, Hong Z, Dai B. Mol Carcinog. 2023 Jul;62(7):940-950. doi: 10.1002/mc.23536. Epub 2023 Apr 10. PubMed |
| Generation of Brown Fat-Specific Knockout Mice Using a Combined Cre-LoxP, CRISPR-Cas9, and Adeno-Associated Virus Single-Guide RNA System. Tsuji T, Zhang Y, Tseng YH. J Vis Exp. 2023 Mar 24;(193):10.3791/65083. doi: 10.3791/65083. PubMed |
| Long Noncoding RNA AROD Inhibits Host Antiviral Innate Immunity via the miR-324-5p-CUEDC2 Axis. Zhang Z, Yu T, Li H, Du L, Jin Z, Peng X, Yan Y, Zhou J, Gu J. Microbiol Spectr. 2023 Jun 15;11(3):e0420622. doi: 10.1128/spectrum.04206-22. Epub 2023 Apr 10. PubMed |
| A kinesin-based approach for inducing chromosome-specific mis-segregation in human cells. Truong MA, Cane-Gasull P, de Vries SG, Nijenhuis W, Wardenaar R, Kapitein LC, Foijer F, Lens SM. EMBO J. 2023 May 15;42(10):e111559. doi: 10.15252/embj.2022111559. Epub 2023 Apr 11. PubMed |
| High-throughput screening of spike variants uncovers the key residues that alter the affinity and antigenicity of SARS-CoV-2. Luo Y, Liu S, Xue J, Yang Y, Zhao J, Sun Y, Wang B, Yin S, Li J, Xia Y, Ge F, Dong J, Guo L, Ye B, Huang W, Wang Y, Xi JJ. Cell Discov. 2023 Apr 11;9(1):40. doi: 10.1038/s41421-023-00534-2. PubMed |
| Structural basis of spike RBM-specific human antibodies counteracting broad SARS-CoV-2 variants. Shitaoka K, Higashiura A, Kawano Y, Yamamoto A, Mizoguchi Y, Hashiguchi T, Nishimichi N, Huang S, Ito A, Ohki S, Kanda M, Taniguchi T, Yoshizato R, Azuma H, Kitajima Y, Yokosaki Y, Okada S, Sakaguchi T, Yasuda T. Commun Biol. 2023 Apr 11;6(1):395. doi: 10.1038/s42003-023-04782-6. PubMed |
| A CRISPR/Cas9-Based Assay for High-Throughput Studies of Cancer-Induced Innervation. Galappaththi SL, Katz B, Howze PH 4th, Hoover G, Grelet S. Cancers (Basel). 2023 Mar 29;15(7):2026. doi: 10.3390/cancers15072026. PubMed |
| Cancer Cell-Derived PDGFB Stimulates mTORC1 Activation in Renal Carcinoma. Abuhamad AY, Mohamad Zamberi NN, Vanharanta S, Mohd Yusuf SNH, Mohtar MA, Syafruddin SE. Int J Mol Sci. 2023 Mar 29;24(7):6447. doi: 10.3390/ijms24076447. PubMed |
| CAPRIN1 Is Required for Control of Viral Replication Complexes by Interferon Gamma. Kurhade C, Kang S, Biering SB, Hwang S, Randall G. mBio. 2023 Jun 27;14(3):e0017223. doi: 10.1128/mbio.00172-23. Epub 2023 Apr 13. PubMed |
| Sphingosine Kinases Promote Ebola Virus Infection and Can Be Targeted to Inhibit Filoviruses, Coronaviruses, and Arenaviruses Using Late Endocytic Trafficking to Enter Cells. Stewart CM, Bo Y, Fu K, Chan M, Kozak R, Apperley KY, Laroche G, Daniel R, Beauchemin AM, Kobinger G, Kobasa D, Cote M. ACS Infect Dis. 2023 May 12;9(5):1064-1077. doi: 10.1021/acsinfecdis.2c00416. Epub 2023 Apr 13. PubMed |
| Cross-Platform Synaptic Network Analysis of Human Entorhinal Cortex Identifies TWF2 as a Modulator of Dendritic Spine Length. Walker CK, Greathouse KM, Tuscher JJ, Dammer EB, Weber AJ, Liu E, Curtis KA, Boros BD, Freeman CD, Seo JV, Ramdas R, Hurst C, Duong DM, Gearing M, Murchison CF, Day JJ, Seyfried NT, Herskowitz JH. J Neurosci. 2023 May 17;43(20):3764-3785. doi: 10.1523/JNEUROSCI.2102-22.2023. Epub 2023 Apr 13. PubMed |
| Quantifying requirements for mitochondrial apoptosis in CAR T killing of cancer cells. Pourzia AL, Olson ML, Bailey SR, Boroughs AC, Aryal A, Ryan J, Maus MV, Letai A. Cell Death Dis. 2023 Apr 13;14(4):267. doi: 10.1038/s41419-023-05727-x. PubMed |
Nucleocytoplasmic transport of active HER2 causes fractional escape from the DCIS-like state.
Wang L, Paudel BB, McKnight RA, Janes KA.
Nat Commun. 2023 Apr 13;14(1):2110. doi: 10.1038/s41467-023-37914-x.
PubMed
Associated Plasmids |
| The roles of toll-like receptor 4, CD33, CD68, CD69, or CD147/EMMPRIN for monocyte activation by the DAMP S100A8/S100A9. Moller A, Jauch-Speer SL, Gandhi S, Vogl T, Roth J, Fehler O. Front Immunol. 2023 Mar 28;14:1110185. doi: 10.3389/fimmu.2023.1110185. eCollection 2023. PubMed |
| Hepatocyte differentiation from mouse liver ductal organoids by transducing 4 liver-specific transcription factors. Tomofuji K, Kondo J, Onuma K, Coppo R, Horie H, Oyama K, Miyoshi E, Fukumitsu K, Ishii T, Hatano E, Inoue M. Hepatol Commun. 2023 Apr 14;7(5):e0134. doi: 10.1097/HC9.0000000000000134. eCollection 2023 May 1. PubMed |
| MALT1 paracaspase is overexpressed in hepatocellular carcinoma and promotes cancer cell survival and growth. Kurden-Pekmezci A, Cakiroglu E, Eris S, Mazi FA, Coskun-Deniz OS, Dalgic E, Oz O, Senturk S. Life Sci. 2023 Jun 15;323:121690. doi: 10.1016/j.lfs.2023.121690. Epub 2023 Apr 13. PubMed |
| CD95/Fas ligand mRNA is toxic to cells through more than one mechanism. Haluck-Kangas A, Fink M, Bartom ET, Peter ME. Mol Biomed. 2023 Apr 15;4(1):11. doi: 10.1186/s43556-023-00119-1. PubMed |
| Claudin-4-adhesion signaling drives breast cancer metabolism and progression via liver X receptor beta. Murakami-Nishimagi Y, Sugimoto K, Kobayashi M, Tachibana K, Kojima M, Okano M, Hashimoto Y, Saji S, Ohtake T, Chiba H. Breast Cancer Res. 2023 Apr 14;25(1):41. doi: 10.1186/s13058-023-01646-z. PubMed |
| PHLPP1 regulates PINK1-parkin signalling and life span. Chandra K, Swathi M, Keerthana B, Gopan S, Ghantasala JP, Joshi MB, Thondamal M, Parsa KVL. Biochim Biophys Acta Mol Basis Dis. 2023 Aug;1869(6):166718. doi: 10.1016/j.bbadis.2023.166718. Epub 2023 Apr 13. PubMed |
| TFCP2 is a transcriptional regulator of heparan sulfate assembly and melanoma cell growth. Basu A, Champagne RN, Patel NG, Nicholson ED, Weiss RJ. J Biol Chem. 2023 Jun;299(6):104713. doi: 10.1016/j.jbc.2023.104713. Epub 2023 Apr 13. PubMed |
| Simultaneous engineering of natural killer cells for CAR transgenesis and CRISPR-Cas9 knockout using retroviral particles. Jo DH, Kaczmarek S, Shin O, Wang L, Cowan J, McComb S, Lee SH. Mol Ther Methods Clin Dev. 2023 Mar 15;29:173-184. doi: 10.1016/j.omtm.2023.03.006. eCollection 2023 Jun 8. PubMed |
| Distinct roles of Bdnf I and Bdnf IV transcript variant expression in hippocampal neurons. Bach SV, Bauman AJ, Hosein D, Tuscher JJ, Ianov L, Greathouse KM, Henderson BW, Herskowitz JH, Martinowich K, Day JJ. bioRxiv. 2023 Apr 5:2023.04.05.535694. doi: 10.1101/2023.04.05.535694. Preprint. PubMed |
| Chromosomal instability can favor macrophage-mediated immune response and induce a broad, vaccination-like anti-tumor IgG response. Hayes BH, Wang M, Zhu H, Phan SH, Andrechak JC, Chang AH, Dooling LJ, Tobin MP, Marchena T, Discher DE. bioRxiv. 2023 Apr 4:2023.04.02.535275. doi: 10.1101/2023.04.02.535275. Preprint. PubMed |
The viral packaging motor potentiates Kaposi's sarcoma-associated herpesvirus gene expression late in infection.
McCollum CO, Didychuk AL, Liu D, Murray-Nerger LA, Cristea IM, Glaunsinger BA.
PLoS Pathog. 2023 Apr 17;19(4):e1011163. doi: 10.1371/journal.ppat.1011163. eCollection 2023 Apr.
PubMed
Associated Plasmids |
| Nonmuscle myosin IIB is a driver of cellular reprogramming. Balaban AE, Nguyen LTS, Parajon E, Robinson DN. Mol Biol Cell. 2023 Jun 1;34(7):ar71. doi: 10.1091/mbc.E21-08-0386. Epub 2023 Apr 19. PubMed |
| CMPK2 restricts Zika virus replication by inhibiting viral translation. Pawlak JB, Hsu JC, Xia H, Han P, Suh HW, Grove TL, Morrison J, Shi PY, Cresswell P, Laurent-Rolle M. PLoS Pathog. 2023 Apr 19;19(4):e1011286. doi: 10.1371/journal.ppat.1011286. eCollection 2023 Apr. PubMed |
| Epigenetic Control of Translation Checkpoint and Tumor Progression via RUVBL1-EEF1A1 Axis. Li M, Yang L, Chan AKN, Pokharel SP, Liu Q, Mattson N, Xu X, Chang WH, Miyashita K, Singh P, Zhang L, Li M, Wu J, Wang J, Chen B, Chan LN, Lee J, Zhang XH, Rosen ST, Muschen M, Qi J, Chen J, Hiom K, Bishop AJR, Chen CW. Adv Sci (Weinh). 2023 Jun;10(17):e2206584. doi: 10.1002/advs.202206584. Epub 2023 Apr 19. PubMed |
| Septin11 promotes hepatocellular carcinoma cell motility by activating RhoA to regulate cytoskeleton and cell adhesion. Fu L, Wang X, Yang Y, Chen M, Kuerban A, Liu H, Dong Y, Cai Q, Ma M, Wu X. Cell Death Dis. 2023 Apr 20;14(4):280. doi: 10.1038/s41419-023-05726-y. PubMed |
| The transcriptional co-activator Yap1 promotes adult hippocampal neural stem cell activation. Fan W, Jurado-Arjona J, Alanis-Lobato G, Peron S, Berger C, Andrade-Navarro MA, Falk S, Berninger B. EMBO J. 2023 Jun 1;42(11):e110384. doi: 10.15252/embj.2021110384. Epub 2023 Apr 21. PubMed |
| TUT4/7-mediated uridylation of a coronavirus subgenomic RNAs delays viral replication. Gupta A, Li Y, Chen SH, Papas BN, Martin NP, Morgan M. Commun Biol. 2023 Apr 21;6(1):438. doi: 10.1038/s42003-023-04814-1. PubMed |
| Genome-wide screen for anticancer drug resistance in haploid human embryonic stem cells. Segal E, Nissenbaum J, Peretz M, Golan-Lev T, Cashman R, Philip H, Reubinoff BE, Kopper O, Benvenisty N. Cell Prolif. 2023 Jun;56(6):e13475. doi: 10.1111/cpr.13475. Epub 2023 Apr 21. PubMed |
| Downregulation of the RNA-binding protein PUM2 facilitates MSC-driven bone regeneration and prevents OVX-induced bone loss. Yoon DS, Choi Y, Lee KM, Ko EA, Kim EJ, Park KH, Lee JW. J Biomed Sci. 2023 Apr 23;30(1):26. doi: 10.1186/s12929-023-00920-8. PubMed |
| MAPT expression is mediated by long-range interactions with cis -regulatory elements. Rogers BB, Anderson AG, Lauzon SN, Davis MN, Hauser RM, Roberts SC, Rodriguez-Nunez I, Trausch-Lowther K, Barinaga EA, Taylor JW, Mackiewicz M, Roberts BS, Cooper SJ, Rizzardi LF, Myers RM, Cochran JN. bioRxiv. 2023 Apr 11:2023.03.07.531520. doi: 10.1101/2023.03.07.531520. Preprint. PubMed |
| Tumor loss-of-function mutations in STK11/LKB1 induce cachexia. Iyengar P, Gandhi AY, Granados J, Guo T, Gupta A, Yu J, Llano EM, Zhang F, Gao A, Kandathil A, Williams D, Gao B, Girard L, Malladi VS, Shelton JM, Evers BM, Hannan R, Ahn C, Minna JD, Infante RE. JCI Insight. 2023 Apr 24;8(8):e165419. doi: 10.1172/jci.insight.165419. PubMed |
| Human DUX4 and mouse Dux interact with STAT1 and broadly inhibit interferon-stimulated gene induction. Spens AE, Sutliff NA, Bennett SR, Campbell AE, Tapscott SJ. Elife. 2023 Apr 24;12:e82057. doi: 10.7554/eLife.82057. PubMed |
| CHD-associated enhancers shape human cardiomyocyte lineage commitment. Armendariz DA, Goetsch SC, Sundarrajan A, Sivakumar S, Wang Y, Xie S, Munshi NV, Hon GC. Elife. 2023 Apr 25;12:e86206. doi: 10.7554/eLife.86206. PubMed |
| Swine IFI6 confers antiviral effects against Japanese encephalitis virus in vitro and in vivo. Qin L, Fan W, Zheng F, Chen H, Qian P, Li X. J Gen Virol. 2023 Apr;104(4). doi: 10.1099/jgv.0.001847. PubMed |
| A tissue injury sensing and repair pathway distinct from host pathogen defense. Liu S, Hur YH, Cai X, Cong Q, Yang Y, Xu C, Bilate AM, Gonzales KAU, Parigi SM, Cowley CJ, Hurwitz B, Luo JD, Tseng T, Gur-Cohen S, Sribour M, Omelchenko T, Levorse J, Pasolli HA, Thompson CB, Mucida D, Fuchs E. Cell. 2023 May 11;186(10):2127-2143.e22. doi: 10.1016/j.cell.2023.03.031. Epub 2023 Apr 24. PubMed |
| Large-scale phage-based screening reveals extensive pan-viral mimicry of host short linear motifs. Mihalic F, Simonetti L, Giudice G, Sander MR, Lindqvist R, Peters MBA, Benz C, Kassa E, Badgujar D, Inturi R, Ali M, Krystkowiak I, Sayadi A, Andersson E, Aronsson H, Soderberg O, Dobritzsch D, Petsalaki E, Overby AK, Jemth P, Davey NE, Ivarsson Y. Nat Commun. 2023 Apr 26;14(1):2409. doi: 10.1038/s41467-023-38015-5. PubMed |
| FBXL4 ubiquitin ligase deficiency promotes mitophagy by elevating NIX levels. Elcocks H, Brazel AJ, McCarron KR, Kaulich M, Husnjak K, Mortiboys H, Clague MJ, Urbe S. EMBO J. 2023 Jul 3;42(13):e112799. doi: 10.15252/embj.2022112799. Epub 2023 Apr 27. PubMed |
| Humoral and T Cell Immune Responses against SARS-CoV-2 after Primary and Homologous or Heterologous Booster Vaccinations and Breakthrough Infection: A Longitudinal Cohort Study in Malaysia. Fu JYL, Pukhari MH, Bador MK, Sam IC, Chan YF. Viruses. 2023 Mar 25;15(4):844. doi: 10.3390/v15040844. PubMed |
| ATG9 vesicles comprise the seed membrane of mammalian autophagosomes. Olivas TJ, Wu Y, Yu S, Luan L, Choi P, Guinn ED, Nag S, De Camilli PV, Gupta K, Melia TJ. J Cell Biol. 2023 Jul 3;222(7):e202208088. doi: 10.1083/jcb.202208088. Epub 2023 Apr 28. PubMed |
| Collagen I-DDR1 signaling promotes hepatocellular carcinoma cell stemness via Hippo signaling repression. Xiong YX, Zhang XC, Zhu JH, Zhang YX, Pan YL, Wu Y, Zhao JP, Liu JJ, Lu YX, Liang HF, Zhang ZG, Zhang WG. Cell Death Differ. 2023 Jul;30(7):1648-1665. doi: 10.1038/s41418-023-01166-5. Epub 2023 Apr 28. PubMed |
| m(6)A epitranscriptomic regulation of tissue homeostasis during primate aging. Wu Z, Lu M, Liu D, Shi Y, Ren J, Wang S, Jing Y, Zhang S, Zhao Q, Li H, Yu Z, Liu Z, Bi S, Wei T, Yang YG, Xiao J, Belmonte JCI, Qu J, Zhang W, Ci W, Liu GH. Nat Aging. 2023 Jun;3(6):705-721. doi: 10.1038/s43587-023-00393-2. Epub 2023 Apr 6. PubMed |
Prediction of efficiencies for diverse prime editing systems in multiple cell types.
Yu G, Kim HK, Park J, Kwak H, Cheong Y, Kim D, Kim J, Kim J, Kim HH.
Cell. 2023 Apr 21:S0092-8674(23)00331-8. doi: 10.1016/j.cell.2023.03.034.
PubMed
Associated Plasmids |
| Senecavirus A-induced glycolysis facilitates virus replication by promoting lactate production that attenuates the interaction between MAVS and RIG-I. Li H, Lin C, Qi W, Sun Z, Xie Z, Jia W, Ning Z. PLoS Pathog. 2023 May 1;19(5):e1011371. doi: 10.1371/journal.ppat.1011371. eCollection 2023 May. PubMed |
| Acetyl-CoA biosynthesis drives resistance to histone acetyltransferase inhibition. Bishop TR, Subramanian C, Bilotta EM, Garnar-Wortzel L, Ramos AR, Zhang Y, Asiaban JN, Ott CJ, Rock CO, Erb MA. Nat Chem Biol. 2023 May 1. doi: 10.1038/s41589-023-01320-7. PubMed |
| miR-21-5p prevents doxorubicin-induced cardiomyopathy by downregulating BTG2. Wang Q, Jiang F, Zhao C, Song J, Hu M, Lv Y, Duan Y, Fang W, Ding R, Qiu Y. Heliyon. 2023 Apr 19;9(5):e15451. doi: 10.1016/j.heliyon.2023.e15451. eCollection 2023 May. PubMed |
| Pharmacological chaperones restore proteostasis of epilepsy-associated GABA (A) receptor variants. Wang YJ, Seibert H, Ahn LY, Schaffer AE, Mu TW. bioRxiv. 2023 Apr 19:2023.04.18.537383. doi: 10.1101/2023.04.18.537383. Preprint. PubMed |
| "Pharmacological inhibition of CLK2 activates YAP by promoting alternative splicing of AMOTL2". Bulos ML, Grzelak EM, Li-Ma C, Chen E, Hull M, Johnson KA, Bollong MJ. bioRxiv. 2023 Apr 19:2023.04.19.537449. doi: 10.1101/2023.04.19.537449. Preprint. PubMed |
| Pharmacological Induction of mesenchymal-epithelial transition chemosensitizes breast cancer cells and prevents metastatic progression. Bagheri M, Mohamed GA, Ashick M, Saleem M, Ognjenovic NB, Lu H, Kolling FW, Wilkins OM, Das S, Croix IS, Nagaraj SH, Muller KE, Gerber SA, Miller TW, Pattabiraman DR. bioRxiv. 2023 Apr 21:2023.04.19.537586. doi: 10.1101/2023.04.19.537586. Preprint. PubMed |
| Ring finger protein 12 activates AKT signalling to promote the progression of liver cancer by interacting with EGFR. Yu C, Rao D, Wang T, Sheng J, Lv E, Zhang L, Lu X, Yu J, Liang H, Song J, Huang W. J Cell Mol Med. 2023 Jun;27(11):1523-1538. doi: 10.1111/jcmm.17757. Epub 2023 May 2. PubMed |
| Single-cell intracellular pH dynamics regulate the cell cycle by timing the G1 exit and G2 transition. Spear JS, White KA. J Cell Sci. 2023 May 15;136(10):jcs260458. doi: 10.1242/jcs.260458. Epub 2023 May 31. PubMed |
| Colocalization of Chikungunya Virus with Its Receptor MXRA8 during Cell Attachment, Internalization, and Membrane Fusion. Feng F, Bouma EM, Hu G, Zhu Y, Yu Y, Smit JM, Diamond MS, Zhang R. J Virol. 2023 May 31;97(5):e0155722. doi: 10.1128/jvi.01557-22. Epub 2023 May 1. PubMed |
| Therapeutic blocking of VEGF binding to neuropilin-2 diminishes PD-L1 expression to activate antitumor immunity in prostate cancer. Wang M, Wisniewski CA, Xiong C, Chhoy P, Goel HL, Kumar A, Zhu LJ, Li R, St Louis PA, Ferreira LM, Pakula H, Xu Z, Loda M, Jiang Z, Brehm MA, Mercurio AM. Sci Transl Med. 2023 May 3;15(694):eade5855. doi: 10.1126/scitranslmed.ade5855. Epub 2023 May 3. PubMed |
| Targeting PD-L2-RGMb overcomes microbiome-related immunotherapy resistance. Park JS, Gazzaniga FS, Wu M, Luthens AK, Gillis J, Zheng W, LaFleur MW, Johnson SB, Morad G, Park EM, Zhou Y, Watowich SS, Wargo JA, Freeman GJ, Kasper DL, Sharpe AH. Nature. 2023 May;617(7960):377-385. doi: 10.1038/s41586-023-06026-3. Epub 2023 May 3. PubMed |
| Pan-cancer analysis revealed H3K4me1 at bivalent promoters premarks DNA hypermethylation during tumor development and identified the regulatory role of DNA methylation in relation to histone modifications. Lu Y, Cao Q, Yu Y, Sun Y, Jiang X, Li X. BMC Genomics. 2023 May 4;24(1):235. doi: 10.1186/s12864-023-09341-1. PubMed |
| Targeting N-linked Glycosylation for the Therapy of Aggressive Lymphomas. Scheich S, Chen J, Liu J, Schnutgen F, Enssle JC, Ceribelli M, Thomas CJ, Choi J, Morris V, Hsiao T, Nguyen H, Wang B, Bolomsky A, Phelan JD, Corcoran S, Urlaub H, Young RM, Haupl B, Wright GW, Huang DW, Ji Y, Yu X, Xu W, Yang Y, Zhao H, Muppidi J, Pan KT, Oellerich T, Staudt LM. Cancer Discov. 2023 Aug 4;13(8):1862-1883. doi: 10.1158/2159-8290.CD-22-1401. PubMed |
Discovery of target genes and pathways at GWAS loci by pooled single-cell CRISPR screens.
Morris JA, Caragine C, Daniloski Z, Domingo J, Barry T, Lu L, Davis K, Ziosi M, Glinos DA, Hao S, Mimitou EP, Smibert P, Roeder K, Katsevich E, Lappalainen T, Sanjana NE.
Science. 2023 May 19;380(6646):eadh7699. doi: 10.1126/science.adh7699. Epub 2023 May 19.
PubMed
Associated Plasmids |
| Deoxyhypusine hydroxylase: A novel therapeutic target differentially expressed in short-term vs long-term survivors of glioblastoma. Ofek P, Yeini E, Arad G, Danilevsky A, Pozzi S, Luna CB, Dangoor SI, Grossman R, Ram Z, Shomron N, Brem H, Hyde TM, Geiger T, Satchi-Fainaro R. Int J Cancer. 2023 Aug 1;153(3):654-668. doi: 10.1002/ijc.34545. Epub 2023 May 4. PubMed |
| PRMT1 inhibition promotes ferroptosis sensitivity via ACSL1 upregulation in acute myeloid leukemia. Zhou L, Jia X, Shang Y, Sun Y, Liu Z, Liu J, Jiang W, Deng S, Yao Q, Chen J, Li H. Mol Carcinog. 2023 Aug;62(8):1119-1135. doi: 10.1002/mc.23550. Epub 2023 May 5. PubMed |
| Twist1-IRF9 Interaction Is Necessary for IFN-Stimulated Gene Anti-Zika Viral Infection. You Y, Grasso E, Alvero A, Condon J, Dimova T, Hu A, Ding J, Alexandrova M, Manchorova D, Dimitrova V, Liao A, Mor G. J Immunol. 2023 May 5:ji2300081. doi: 10.4049/jimmunol.2300081. PubMed |
| CpG dinucleotide enrichment in the influenza A virus genome as a live attenuated vaccine development strategy. Sharp CP, Thompson BH, Nash TJ, Diebold O, Pinto RM, Thorley L, Lin YT, Sives S, Wise H, Clohisey Hendry S, Grey F, Vervelde L, Simmonds P, Digard P, Gaunt ER. PLoS Pathog. 2023 May 5;19(5):e1011357. doi: 10.1371/journal.ppat.1011357. eCollection 2023 May. PubMed |
| XRN2 suppresses aberrant entry of tRNA trailers into argonaute in humans and Arabidopsis. Wilson B, Su Z, Kumar P, Dutta A. PLoS Genet. 2023 May 5;19(5):e1010755. doi: 10.1371/journal.pgen.1010755. eCollection 2023 May. PubMed |
| The adapter protein FADD provides an alternate pathway for entry into the cell cycle by regulating APC/C-Cdh1 E3 ubiquitin ligase activity. Awadia S, Sitto M, Ram S, Ji W, Liu Y, Damani R, Ray D, Lawrence TS, Galban CJ, Cappell SD, Rehemtulla A. J Biol Chem. 2023 Jun;299(6):104786. doi: 10.1016/j.jbc.2023.104786. Epub 2023 May 4. PubMed |
| Methionine consumption by cancer cells drives a progressive upregulation of PD-1 expression in CD4 T cells. Pandit M, Kil YS, Ahn JH, Pokhrel RH, Gu Y, Mishra S, Han Y, Ouh YT, Kang B, Jeong MS, Kim JO, Nam JW, Ko HJ, Chang JH. Nat Commun. 2023 May 5;14(1):2593. doi: 10.1038/s41467-023-38316-9. PubMed |
| Piezo1 opposes age-associated cortical bone loss. Li X, Zhang C, Bowman HH, Stambough JB, Stronach BM, Mears SC, Barnes LC, Ambrogini E, Xiong J. Aging Cell. 2023 Jun;22(6):e13846. doi: 10.1111/acel.13846. Epub 2023 May 5. PubMed |
| Mitochondrial citrate metabolism and efflux regulate BeWo differentiation. Mahr RM, Jena S, Nashif SK, Nelson AB, Rauckhorst AJ, Rome FI, Sheldon RD, Hughey CC, Puchalska P, Gearhart MD, Taylor EB, Crawford PA, Wernimont SA. Sci Rep. 2023 May 6;13(1):7387. doi: 10.1038/s41598-023-34435-x. PubMed |
| Anticancer effect of involucrasin A on colorectal cancer cells by modulating the Akt/MDM2/p53 pathway. Wei C, Du J, Shen Y, Wang Z, Lin Q, Chen J, Zhang F, Lin W, Wang Z, Yang Z, Ma W. Oncol Lett. 2023 Apr 12;25(6):218. doi: 10.3892/ol.2023.13804. eCollection 2023 Jun. PubMed |
| Syngeneic mouse model of human HER2+ metastatic breast cancer for the evaluation of trastuzumab emtansine combined with oncolytic rhabdovirus. Taha Z, Crupi MJF, Alluqmani N, Fareez F, Ng K, Sobh J, Lee E, Chen A, Thomson M, Spinelli MM, Ilkow CS, Bell JC, Arulanandam R, Diallo JS. Front Immunol. 2023 Apr 19;14:1181014. doi: 10.3389/fimmu.2023.1181014. eCollection 2023. PubMed |
| ZFP92, a KRAB domain zinc finger protein enriched in pancreatic islets, binds to B1/Alu SINE transposable elements and regulates retroelements and genes. Osipovich AB, Dudek KD, Trinh LT, Kim LH, Shrestha S, Cartailler JP, Magnuson MA. PLoS Genet. 2023 May 8;19(5):e1010729. doi: 10.1371/journal.pgen.1010729. eCollection 2023 May. PubMed |
| Generalized Strategy for Engineering Mammalian Cell-Compatible RNA-Based Biosensors from Random Sequence Libraries. Allchin ER, Rosch JC, Stoneman AD, Kim H, Lippmann ES. ACS Sens. 2023 May 26;8(5):2079-2086. doi: 10.1021/acssensors.3c00388. Epub 2023 May 8. PubMed |
| ptARgenOM-A Flexible Vector For CRISPR/CAS9 Nonviral Delivery. Radoua A, Pernon B, Pernet N, Jean C, Elmallah M, Guerrache A, Constantinescu AA, Hadj Hamou S, Devy J, Micheau O. Small Methods. 2023 Jul;7(7):e2300069. doi: 10.1002/smtd.202300069. Epub 2023 May 8. PubMed |
| Local Monomer Levels and Established Filaments Potentiate Non-Muscle Myosin 2 Assembly. Quintanilla MA, Patel H, Wu H, Sochacki KA, Akamatsu M, Rotty JD, Korobova F, Bear JE, Taraska JW, Oakes PW, Beach JR. bioRxiv. 2023 Apr 27:2023.04.26.538303. doi: 10.1101/2023.04.26.538303. Preprint. PubMed |
| Genome-wide analysis of CRISPR perturbations indicates that enhancers act multiplicatively and without epistatic-like interactions. Zhou J, Guruvayurappan K, Chen HV, Chen AR, McVicker G. bioRxiv. 2023 Apr 27:2023.04.26.538501. doi: 10.1101/2023.04.26.538501. Preprint. PubMed |
| The short-chain fatty acid acetate coordinates with CD30 to modulate T-cell survival. Lyu J, Li Z, Roberts JP, Qi YA, Xiong J. Mol Biol Cell. 2023 Jul 1;34(8):br11. doi: 10.1091/mbc.E23-01-0032. Epub 2023 May 10. PubMed |
| Mitotic clustering of pulverized chromosomes from micronuclei. Lin YF, Hu Q, Mazzagatti A, Valle-Inclan JE, Maurais EG, Dahiya R, Guyer A, Sanders JT, Engel JL, Nguyen G, Bronder D, Bakhoum SF, Cortes-Ciriano I, Ly P. Nature. 2023 Jun;618(7967):1041-1048. doi: 10.1038/s41586-023-05974-0. Epub 2023 May 10. PubMed |
| SELENOP modifies sporadic colorectal carcinogenesis and WNT signaling activity through LRP5/6 interactions. Pilat JM, Brown RE, Chen Z, Berle NJ, Othon AP, Washington MK, Anant SA, Kurokawa S, Ng VH, Thompson JJ, Jacobse J, Goettel JA, Lee E, Choksi YA, Lau KS, Short SP, Williams CS. J Clin Invest. 2023 Jul 3;133(13):e165988. doi: 10.1172/JCI165988. PubMed |
| METTL3 regulates alternative splicing of cell cycle-related genes via crosstalk between mRNA m(6)A modifications and splicing factors. Kim Y, Shin S, Kwon S, Moon K, Baek SV, Jo A, Kim HS, Hwang GH, Bae S, Kim YH, Cho SY, Oh JM. Am J Cancer Res. 2023 Apr 15;13(4):1443-1456. eCollection 2023. PubMed |
| A computationally designed ACE2 decoy has broad efficacy against SARS-CoV-2 omicron variants and related viruses in vitro and in vivo. Havranek B, Lindsey GW, Higuchi Y, Itoh Y, Suzuki T, Okamoto T, Hoshino A, Procko E, Islam SM. Commun Biol. 2023 May 12;6(1):513. doi: 10.1038/s42003-023-04860-9. PubMed |
| Promotive Effect of FBXO32 on the Odontoblastic Differentiation of Human Dental Pulp Stem Cells. Xu K, Liu Q, Huang W, Chu Y, Fan W, Liu J, He Y, Huang F. Int J Mol Sci. 2023 Apr 22;24(9):7708. doi: 10.3390/ijms24097708. PubMed |
| Extracellular Tau Oligomers Damage the Axon Initial Segment. Best MN, Lim Y, Ferenc NN, Kim N, Min L, Wang DB, Sharifi K, Wasserman AE, McTavish SA, Siller KH, Jones MK, Jenkins PM, Mandell JW, Bloom GS. J Alzheimers Dis. 2023;93(4):1425-1441. doi: 10.3233/JAD-221284. PubMed |
| Epigenetic landscape reveals MECOM as an endothelial lineage regulator. Lv J, Meng S, Gu Q, Zheng R, Gao X, Kim JD, Chen M, Xia B, Zuo Y, Zhu S, Zhao D, Li Y, Wang G, Wang X, Meng Q, Cao Q, Cooke JP, Fang L, Chen K, Zhang L. Nat Commun. 2023 Apr 25;14(1):2390. doi: 10.1038/s41467-023-38002-w. PubMed |
| Secreted ADAMTS-like 2 promotes myoblast differentiation by potentiating WNT signaling. Taye N, Singh M, Baldock C, Hubmacher D. Matrix Biol. 2023 Jun;120:24-42. doi: 10.1016/j.matbio.2023.05.003. Epub 2023 May 14. PubMed |
| Enhanced sensitivity of neutralizing antibody detection for different AAV serotypes using HeLa cells with overexpressed AAVR. Zheng Z, Ye J, Leng M, Gan C, Tang N, Li W, Valencia CA, Dong B, Chow HY. Front Pharmacol. 2023 Apr 27;14:1188290. doi: 10.3389/fphar.2023.1188290. eCollection 2023. PubMed |
| Integrative genomic analyses in adipocytes implicate DNA methylation in human obesity and diabetes. McAllan L, Baranasic D, Villicana S, Brown S, Zhang W, Lehne B, Adamo M, Jenkinson A, Elkalaawy M, Mohammadi B, Hashemi M, Fernandes N, Lambie N, Williams R, Christiansen C, Yang Y, Zudina L, Lagou V, Tan S, Castillo-Fernandez J, King JWD, Soong R, Elliott P, Scott J, Prokopenko I, Cebola I, Loh M, Lenhard B, Batterham RL, Bell JT, Chambers JC, Kooner JS, Scott WR. Nat Commun. 2023 May 15;14(1):2784. doi: 10.1038/s41467-023-38439-z. PubMed |
| RagD auto-activating mutations impair MiT/TFE activity in kidney tubulopathy and cardiomyopathy syndrome. Sambri I, Ferniani M, Campostrini G, Testa M, Meraviglia V, de Araujo MEG, Dokladal L, Vilardo C, Monfregola J, Zampelli N, Vecchio Blanco FD, Torella A, Ruosi C, Fecarotta S, Parenti G, Staiano L, Bellin M, Huber LA, De Virgilio C, Trepiccione F, Nigro V, Ballabio A. Nat Commun. 2023 May 15;14(1):2775. doi: 10.1038/s41467-023-38428-2. PubMed |
| Galectin-1 promotes angiogenesis and chondrogenesis during antler regeneration. Li X, Shi W, Wei G, Lv J, Wang D, Xing B, Zhou J, Zhao J, Sun H. Cell Mol Biol Lett. 2023 May 15;28(1):40. doi: 10.1186/s11658-023-00456-7. PubMed |
| Signal-Retaining Autophagy Indicator as a Quantitative Imaging Method for ER-Phagy. Jimenez-Moreno N, Salomo-Coll C, Murphy LC, Wilkinson S. Cells. 2023 Apr 11;12(8):1134. doi: 10.3390/cells12081134. PubMed |
| FLI1 Regulates Histamine Decarboxylase Expression to Control Inflammation Signaling and Leukemia Progression. Hu J, Gao J, Wang C, Liu W, Hu A, Xiao X, Kuang Y, Yu K, Gajendran B, Zacksenhaus E, Pan W, Ben-David Y. J Inflamm Res. 2023 May 10;16:2007-2020. doi: 10.2147/JIR.S401566. eCollection 2023. PubMed |
| Pseudophosphatase STYXL1 depletion enhances glucocerebrosidase trafficking to lysosomes via ER stress. Patel S, Bhatt AM, Bhansali P, Setty SRG. Traffic. 2023 Jul;24(7):254-269. doi: 10.1111/tra.12886. Epub 2023 May 17. PubMed |
| A selectivity filter in the ER membrane protein complex limits protein misinsertion at the ER. Pleiner T, Hazu M, Pinton Tomaleri G, Nguyen VN, Januszyk K, Voorhees RM. J Cell Biol. 2023 Aug 7;222(8):e202212007. doi: 10.1083/jcb.202212007. Epub 2023 May 18. PubMed |
| Differential cell-cycle control by oscillatory versus sustained Hes1 expression via p21. Maeda Y, Isomura A, Masaki T, Kageyama R. Cell Rep. 2023 May 30;42(5):112520. doi: 10.1016/j.celrep.2023.112520. Epub 2023 May 17. PubMed |
| Repurposing CRISPR/Cas to Discover SARS-CoV-2 Detecting and Neutralizing Aptamers. Zhang J, Zhu A, Mei M, Qu J, Huang Y, Shi Y, Xue M, Zhang J, Zhang R, Zhou B, Tan X, Zhao J, Wang Y. Adv Sci (Weinh). 2023 Aug;10(22):e2300656. doi: 10.1002/advs.202300656. Epub 2023 May 19. PubMed |
| IL-6 is dispensable for causing cachexia in the colon carcinoma 26 model. Kwon YY, Hui S. bioRxiv. 2023 May 2:2023.05.02.539076. doi: 10.1101/2023.05.02.539076. Preprint. PubMed |
| Keratin isoform shifts modulate motility signals during wound healing. Nanes BA, Bhatt K, Azarova E, Rajendran D, Isogai T, Dean KM, Danuser G. bioRxiv. 2023 May 5:2023.05.04.538989. doi: 10.1101/2023.05.04.538989. Preprint. PubMed |
| Mechanisms controlling membrane recruitment and activation of autoinhibited SHIP1. Waddell GL, Drew EE, Rupp HP, Hansen SD. bioRxiv. 2023 May 1:2023.04.30.538895. doi: 10.1101/2023.04.30.538895. Preprint. PubMed |
| Parallel genome-scale CRISPR screens distinguish pluripotency and self-renewal. Rosen BP, Li QV, Cho H, Liu D, Yang D, Graff S, Yan J, Luo R, Verma N, Damodaran JR, Beer MA, Sidoli S, Huangfu D. bioRxiv. 2023 May 3:2023.05.03.539283. doi: 10.1101/2023.05.03.539283. Preprint. PubMed |
| The lipase cofactor CGI58 controls placental lipolysis. Guerrero-Santoro J, Morizane M, Oh SY, Mishima T, Goff JP, Bildirici I, Sadovsky E, Ouyang Y, Tyurin VA, Tyurina YY, Kagan VE, Sadovsky Y. JCI Insight. 2023 May 22;8(10):e168717. doi: 10.1172/jci.insight.168717. PubMed |
| Structural and functional damage to neuronal nuclei caused by extracellular tau oligomers. Sun X, Eastman G, Shi Y, Saibaba S, Oliveira AK, Lukens JR, Norambuena A, Mandell JW, Bloom GS. bioRxiv. 2023 May 8:2023.05.08.539873. doi: 10.1101/2023.05.08.539873. Preprint. PubMed |
| A genome-wide screen in macrophages identifies PTEN as required for myeloid restriction of Listeria monocytogenes infection. Glover RC, Schwardt NH, Leano SE, Sanchez ME, Thomason MK, Olive AJ, Reniere ML. PLoS Pathog. 2023 May 22;19(5):e1011058. doi: 10.1371/journal.ppat.1011058. eCollection 2023 May. PubMed |
| Synthetic Epigenetic Reprogramming of Mesenchymal to Epithelial States Using the CRISPR/dCas9 Platform in Triple Negative Breast Cancer. Waryah C, Cursons J, Foroutan M, Pflueger C, Wang E, Molania R, Woodward E, Sorolla A, Wallis C, Moses C, Glas I, Magalhaes L, Thompson EW, Fearnley LG, Chaffer CL, Davis M, Papenfuss AT, Redfern A, Lister R, Esteller M, Blancafort P. Adv Sci (Weinh). 2023 Aug;10(22):e2301802. doi: 10.1002/advs.202301802. Epub 2023 May 22. PubMed |
Coupled protein quality control during nonsense-mediated mRNA decay.
Inglis AJ, Guna A, Galvez-Merchan A, Pal A, Esantsi TK, Keys HR, Frenkel EM, Oania R, Weissman JS, Voorhees RM.
J Cell Sci. 2023 May 15;136(10):jcs261216. doi: 10.1242/jcs.261216. Epub 2023 May 23.
PubMed
Associated Plasmids |
| Regulation of CD19 CAR-T cell activation based on an engineered downstream transcription factor. Lainscek D, Golob-Urbanc A, Mikolic V, Pantovic-Zalig J, Malensek S, Jerala R. Mol Ther Oncolytics. 2023 Apr 26;29:77-90. doi: 10.1016/j.omto.2023.04.005. eCollection 2023 Jun 15. PubMed |
| Actin nucleators safeguard replication forks by limiting nascent strand degradation. Nieminuszczy J, Martin PR, Broderick R, Krwawicz J, Kanellou A, Mocanu C, Bousgouni V, Smith C, Wen KK, Woodward BL, Bakal C, Shackley F, Aguilera A, Stewart GS, Vyas YM, Niedzwiedz W. Nucleic Acids Res. 2023 Jul 7;51(12):6337-6354. doi: 10.1093/nar/gkad369. PubMed |
| Dysregulation of iron homeostasis by TfR-1 renders EZH2 wild type diffuse large B-cell lymphoma resistance to EZH2 inhibition. Yu L, Wang YF, Xiao J, Shen QQ, Chi SS, Gao YL, Lin DZ, Ding J, Fang YF, Chen Y. Acta Pharmacol Sin. 2023 May 25. doi: 10.1038/s41401-023-01097-4. PubMed |
| Neddylation inhibition sensitises renal medullary carcinoma tumours to platinum chemotherapy. Shapiro DD, Zacharias NM, Tripathi DN, Karki M, Bertocchio JP, Soeung M, He R, Westerman ME, Gao J, Rao P, Lam TNA, Jonasch E, Perelli L, Cheng EH, Carugo A, Heffernan TP, Walker CL, Genovese G, Tannir NM, Karam JA, Msaouel P. Clin Transl Med. 2023 May;13(5):e1267. doi: 10.1002/ctm2.1267. PubMed |
| Phosphorylation of IWS1 by AKT maintains liposarcoma tumor heterogeneity through preservation of cancer stem cell phenotypes and mesenchymal-epithelial plasticity. Wang Y, Zhang H, La Ferlita A, Sp N, Goryunova M, Sarchet P, Hu Z, Sorkin M, Kim A, Huang H, Zhu H, Tsung A, Pollock RE, Beane JD. Oncogenesis. 2023 May 26;12(1):30. doi: 10.1038/s41389-023-00469-z. PubMed |
| Genome-scale functional genomics identify genes preferentially essential for multiple myeloma cells compared to other neoplasias. de Matos Simoes R, Shirasaki R, Downey-Kopyscinski SL, Matthews GM, Barwick BG, Gupta VA, Dupere-Richer D, Yamano S, Hu Y, Sheffer M, Dhimolea E, Dashevsky O, Gandolfi S, Ishiguro K, Meyers RM, Bryan JG, Dharia NV, Hengeveld PJ, Bruggenthies JB, Tang H, Aguirre AJ, Sievers QL, Ebert BL, Glassner BJ, Ott CJ, Bradner JE, Kwiatkowski NP, Auclair D, Levy J, Keats JJ, Groen RWJ, Gray NS, Culhane AC, McFarland JM, Dempster JM, Licht JD, Boise LH, Hahn WC, Vazquez F, Tsherniak A, Mitsiades CS. Nat Cancer. 2023 May;4(5):754-773. doi: 10.1038/s43018-023-00550-x. Epub 2023 May 26. PubMed |
| Screening of Membrane Protein Production by Comparison of Transient Expression in Insect and Mammalian Cells. Kaipa JM, Krasnoselska G, Owens RJ, van den Heuvel J. Biomolecules. 2023 May 11;13(5):817. doi: 10.3390/biom13050817. PubMed |
| ATP13A2 activates the pentose phosphate pathway to promote colorectal cancer growth though TFEB-PGD axis. Zhang F, Wu Z, Yu B, Ning Z, Lu Z, Li L, Long F, Hu Q, Zhong C, Zhang Y, Lin C. Clin Transl Med. 2023 May;13(5):e1272. doi: 10.1002/ctm2.1272. PubMed |
| Multiplex gene editing to promote cell survival using low-pH clustered regularly interspaced short palindromic repeats activation (CRISPRa) gene perturbation. Levis H, Weston J, Austin B, Larsen B, Ginley-Hidinger M, Gullbrand SE, Lawrence B, Bowles RD. Cytotherapy. 2023 May 27:S1465-3249(23)00932-5. doi: 10.1016/j.jcyt.2023.05.001. PubMed |
| A previously uncharacterized Factor Associated with Metabolism and Energy (FAME/C14orf105/CCDC198/1700011H14Rik) is related to evolutionary adaptation, energy balance, and kidney physiology. Petersen J, Englmaier L, Artemov AV, Poverennaya I, Mahmoud R, Bouderlique T, Tesarova M, Deviatiiarov R, Szilvasy-Szabo A, Akkuratov EE, Pajuelo Reguera D, Zeberg H, Kaucka M, Kastriti ME, Krivanek J, Radaszkiewicz T, Gomoryova K, Knauth S, Potesil D, Zdrahal Z, Ganji RS, Grabowski A, Buhl ME, Zikmund T, Kavkova M, Axelson H, Lindgren D, Kramann R, Kuppe C, Erdelyi F, Mate Z, Szabo G, Koehne T, Harkany T, Fried K, Kaiser J, Boor P, Fekete C, Rozman J, Kasparek P, Prochazka J, Sedlacek R, Bryja V, Gusev O, Adameyko I. Nat Commun. 2023 May 29;14(1):3092. doi: 10.1038/s41467-023-38663-7. PubMed |
| Immunogenetic Metabolomics Reveals Key Enzymes That Modulate CAR T-cell Metabolism and Function. Renauer P, Park JJ, Bai M, Acosta A, Lee WH, Lin GH, Zhang Y, Dai X, Wang G, Errami Y, Wu T, Clark P, Ye L, Yang Q, Chen S. Cancer Immunol Res. 2023 Aug 3;11(8):1068-1084. doi: 10.1158/2326-6066.CIR-22-0565. PubMed |
| Single-Cell Evolutionary Analysis Reveals Drivers of Plasticity and Mediators of Chemoresistance in Small Cell Lung Cancer. Wollenzien H, Tecleab YAA, Szczepaniak-Sloane R, Restaino A, Kareta MS. Mol Cancer Res. 2023 May 31:MCR-22-0881. doi: 10.1158/1541-7786.MCR-22-0881. PubMed |
| FIRRM/C1orf112 mediates resolution of homologous recombination intermediates in response to DNA interstrand crosslinks. Mazouzi A, Moser SC, Abascal F, van den Broek B, Del Castillo Velasco-Herrera M, van der Heijden I, Hekkelman M, Drenth AP, van der Burg E, Kroese LJ, Jalink K, Adams DJ, Jonkers J, Brummelkamp TR. Sci Adv. 2023 Jun 2;9(22):eadf4409. doi: 10.1126/sciadv.adf4409. Epub 2023 May 31. PubMed |
| RTK signalling promotes epithelial columnar cell shape and apical junction maintenance in human lung progenitor cells. Liu S, Sun D, Butler R, Rawlins EL. Development. 2023 Jun 1;150(11):dev201284. doi: 10.1242/dev.201284. Epub 2023 Jun 1. PubMed |
| Co-cultures of colon cancer cells and cancer-associated fibroblasts recapitulate the aggressive features of mesenchymal-like colon cancer. Strating E, Verhagen MP, Wensink E, Dunnebach E, Wijler L, Aranguren I, De la Cruz AS, Peters NA, Hageman JH, van der Net MMC, van Schelven S, Laoukili J, Fodde R, Roodhart J, Nierkens S, Snippert H, Gloerich M, Rinkes IB, Elias SG, Kranenburg O. Front Immunol. 2023 May 16;14:1053920. doi: 10.3389/fimmu.2023.1053920. eCollection 2023. PubMed |
| Mitochondrial-Encoded Complex I Impairment Induces a Targetable Dependency on Aerobic Fermentation in Hurthle Cell Carcinoma of the Thyroid. Frank AR, Li V, Shelton SD, Kim J, Stott GM, Neckers LM, Xie Y, Williams NS, Mishra P, McFadden DG. Cancer Discov. 2023 Aug 4;13(8):1884-1903. doi: 10.1158/2159-8290.CD-22-0982. PubMed |
| A genome-wide genetic screen identifies CYRI-B as a negative regulator of CEACAM3-mediated phagocytosis. Kuiper JWP, Krause J, Potgeter L, Adrian J, Hauck CR. J Cell Sci. 2023 Jun 1;136(11):jcs260771. doi: 10.1242/jcs.260771. Epub 2023 Jun 2. PubMed |
| Scanning mutagenesis of the voltage-gated sodium channel Na(V)1.2 using base editing. Pablo JLB, Cornett SL, Wang LA, Jo S, Brunger T, Budnik N, Hegde M, DeKeyser JM, Thompson CH, Doench JG, Lal D, George AL Jr, Pan JQ. Cell Rep. 2023 Jun 1;42(6):112563. doi: 10.1016/j.celrep.2023.112563. PubMed |
| RHOJ as a novel mechanosensitive modulator of endothelial inflammation. Liu W, Zeng Y, Huang L, Zhang X, Bi L, Fan W, Wu G. Biochem Biophys Res Commun. 2023 Aug 30;670:36-46. doi: 10.1016/j.bbrc.2023.05.099. Epub 2023 May 26. PubMed |
| Deficiency of the Polycomb Protein RYBP and TET Methylcytosine Oxidases Promotes Extensive CpG Island Hypermethylation and Malignant Transformation. Cui W, Huang Z, Jin SG, Johnson J, Lau KH, Hostetter G, Pfeifer GP. Cancer Res. 2023 Aug 1;83(15):2480-2495. doi: 10.1158/0008-5472.CAN-23-0269. PubMed |
| SETD4 Confers Cancer Stem Cell Chemoresistance in Nonsmall Cell Lung Cancer Patients via the Epigenetic Regulation of Cellular Quiescence. Wang Y, Yu Y, Yang W, Wu L, Yang Y, Lu Q, Zhou J. Stem Cells Int. 2023 May 27;2023:7367854. doi: 10.1155/2023/7367854. eCollection 2023. PubMed |
| Over-expression of ADAR1 in mice does not initiate or accelerate cancer formation in vivo. Mendez Ruiz S, Chalk AM, Goradia A, Heraud-Farlow J, Walkley CR. NAR Cancer. 2023 Jun 1;5(2):zcad023. doi: 10.1093/narcan/zcad023. eCollection 2023 Jun. PubMed |
| The PRMT5/WDR77 complex restricts hepatitis E virus replication. Ju X, Yu Y, Ren W, Dong L, Meng X, Deng H, Nan Y, Ding Q. PLoS Pathog. 2023 Jun 5;19(6):e1011434. doi: 10.1371/journal.ppat.1011434. eCollection 2023 Jun. PubMed |
| NALCN-mediated sodium influx confers metastatic prostate cancer cell invasiveness. Folcher A, Gordienko D, Iamshanova O, Bokhobza A, Shapovalov G, Kannancheri-Puthooru D, Mariot P, Allart L, Desruelles E, Spriet C, Diez R, Oullier T, Marionneau-Lambot S, Brisson L, Geraci S, Impheng H, Lehen'kyi V, Haustrate A, Mihalache A, Gosset P, Chadet S, Retif S, Laube M, Sobilo J, Lerondel S, Villari G, Serini G, Pla AF, Roger S, Fromont-Hankard G, Djamgoz M, Clezardin P, Monteil A, Prevarskaya N. EMBO J. 2023 Jul 3;42(13):e112198. doi: 10.15252/embj.2022112198. Epub 2023 Jun 6. PubMed |
| Identification of a DeltaNp63-Dependent Basal-Like A Subtype-Specific Transcribed Enhancer Program (B-STEP) in Aggressive Pancreatic Ductal Adenocarcinoma. Wang X, Kutschat AP, Aggrey-Fynn J, Hamdan FH, Graham RP, Wixom AQ, Souto Y, Ladigan-Badura S, Yonkus JA, Abdelrahman AM, Alva-Ruiz R, Gaedcke J, Strobel P, Kosinsky RL, Wegwitz F, Hermann P, Truty MJ, Siveke JT, Hahn SA, Hessmann E, Johnsen SA, Najafova Z. Mol Cancer Res. 2023 Sep 1;21(9):881-891. doi: 10.1158/1541-7786.MCR-22-0916. PubMed |
| T cell-Mediated Development of Stromal Fibroblasts with an Immune-Enhancing Chemokine Profile. Yan R, Moresco P, Gegenhuber B, Fearon DT. Cancer Immunol Res. 2023 Jun 7:OF1-OF11. doi: 10.1158/2326-6066.CIR-22-0593. PubMed |
| Host-specific sensing of coronaviruses and picornaviruses by the CARD8 inflammasome. Tsu BV, Agarwal R, Gokhale NS, Kulsuptrakul J, Ryan AP, Fay EJ, Castro LK, Beierschmitt C, Yap C, Turcotte EA, Delgado-Rodriguez SE, Vance RE, Hyde JL, Savan R, Mitchell PS, Daugherty MD. PLoS Biol. 2023 Jun 8;21(6):e3002144. doi: 10.1371/journal.pbio.3002144. eCollection 2023 Jun. PubMed |
| Generation of a new Adar1p150 (-/-) mouse demonstrates isoform-specific roles in embryonic development and adult homeostasis. Liang Z, Goradia A, Walkley CR, Heraud-Farlow JE. RNA. 2023 Sep;29(9):1325-1338. doi: 10.1261/rna.079509.122. Epub 2023 Jun 8. PubMed |
| Somatic mutations of CADM1 in aldosterone-producing adenomas and gap junction-dependent regulation of aldosterone production. Wu X, Azizan EAB, Goodchild E, Garg S, Hagiyama M, Cabrera CP, Fernandes-Rosa FL, Boulkroun S, Kuan JL, Tiang Z, David A, Murakami M, Mein CA, Wozniak E, Zhao W, Marker A, Buss F, Saleeb RS, Salsbury J, Tezuka Y, Satoh F, Oki K, Udager AM, Cohen DL, Wachtel H, King PJ, Drake WM, Gurnell M, Ceral J, Ryska A, Mustangin M, Wong YP, Tan GC, Solar M, Reincke M, Rainey WE, Foo RS, Takaoka Y, Murray SA, Zennaro MC, Beuschlein F, Ito A, Brown MJ. Nat Genet. 2023 Jun;55(6):1009-1021. doi: 10.1038/s41588-023-01403-0. Epub 2023 Jun 8. PubMed |
| Tumour mutations in long noncoding RNAs enhance cell fitness. Esposito R, Lanzos A, Uroda T, Ramnarayanan S, Buchi I, Polidori T, Guillen-Ramirez H, Mihaljevic A, Merlin BM, Mela L, Zoni E, Hovhannisyan L, McCluggage F, Medo M, Basile G, Meise DF, Zwyssig S, Wenger C, Schwarz K, Vancura A, Bosch-Guiteras N, Andrades A, Tham AM, Roemmele M, Ochsenbein AF, Riether C, Kruithof-de Julio M, Zimmer Y, Medova M, Stroka D, Fox A, Johnson R. Nat Commun. 2023 Jun 8;14(1):3342. doi: 10.1038/s41467-023-39160-7. PubMed |
| Architecture and dynamics of a desmosome-endoplasmic reticulum complex. Bharathan NK, Giang W, Hoffman CL, Aaron JS, Khuon S, Chew TL, Preibisch S, Trautman ET, Heinrich L, Bogovic J, Bennett D, Ackerman D, Park W, Petruncio A, Weigel AV, Saalfeld S, Wayne Vogl A, Stahley SN, Kowalczyk AP. Nat Cell Biol. 2023 Jun;25(6):823-835. doi: 10.1038/s41556-023-01154-4. Epub 2023 Jun 8. PubMed |
| Transcriptomic and functional analysis of ANGPTL4 overexpression in pancreatic cancer nominates targets that reverse chemoresistance. Gordon ER, Wright CA, James M, Cooper SJ. BMC Cancer. 2023 Jun 8;23(1):524. doi: 10.1186/s12885-023-11010-1. PubMed |
| Stimulator of interferon genes is required for Toll-Like Receptor-8 induced interferon response. Garcia-Martinez K, Chen J, Jones J, Woo A, Aucapina A, Brito I, Leifer CA. bioRxiv. 2023 May 16:2023.05.15.540812. doi: 10.1101/2023.05.15.540812. Preprint. PubMed |
| HIV-1 Vpr-induced DNA damage activates NF-kappaB through ATM-NEMO independent of cell cycle arrest. Sandoval C, Nisson K, Fregoso OI. bioRxiv [Preprint]. 2024 Jan 25:2023.05.23.541990. doi: 10.1101/2023.05.23.541990. PubMed |
| IGFBP7 Fuels the Glycolytic Metabolism in B-Cell Precursor Acute Lymphoblastic Leukemia by Sustaining Activation of the IGF1R-Akt-GLUT1 Axis. Artico LL, Ruas JS, Teixeira Junior JR, Migita NA, Seguchi G, Shi X, Brandalise SR, Castilho RF, Yunes JA. Int J Mol Sci. 2023 Jun 2;24(11):9679. doi: 10.3390/ijms24119679. PubMed |
| Impaired histone inheritance promotes tumor progression. Tian C, Zhou J, Li X, Gao Y, Wen Q, Kang X, Wang N, Yao Y, Jiang J, Song G, Zhang T, Hu S, Liao J, Yu C, Wang Z, Liu X, Pei X, Chan K, Liu Z, Gan H. Nat Commun. 2023 Jun 10;14(1):3429. doi: 10.1038/s41467-023-39185-y. PubMed |
| VPS37C facilitates erythroid differentiation by promoting EKLF stability. Lu Y, Ma WB, Ren GM, Liu X, Li YT, Wang T, Zhan YQ, Xiang SS, Yu M, Li CY, Yang XM, Yin RH. Biochem Biophys Res Commun. 2023 Sep 3;671:229-235. doi: 10.1016/j.bbrc.2023.06.023. Epub 2023 Jun 7. PubMed |
| Ceramide sensing by human SPT-ORMDL complex for establishing sphingolipid homeostasis. Xie T, Liu P, Wu X, Dong F, Zhang Z, Yue J, Mahawar U, Farooq F, Vohra H, Fang Q, Liu W, Wattenberg BW, Gong X. Nat Commun. 2023 Jun 13;14(1):3475. doi: 10.1038/s41467-023-39274-y. PubMed |
| High-throughput measurement of the content and properties of nano-sized bioparticles with single-particle profiler. Sych T, Schlegel J, Barriga HMG, Ojansivu M, Hanke L, Weber F, Beklem Bostancioglu R, Ezzat K, Stangl H, Plochberger B, Laurencikiene J, El Andaloussi S, Furth D, Stevens MM, Sezgin E. Nat Biotechnol. 2023 Jun 12. doi: 10.1038/s41587-023-01825-5. PubMed |
| Inhalable CAR-T cell-derived exosomes as paclitaxel carriers for treating lung cancer. Zheng W, Zhu T, Tang L, Li Z, Jiang G, Huang X. J Transl Med. 2023 Jun 12;21(1):383. doi: 10.1186/s12967-023-04206-3. PubMed |
| An Epstein-Barr virus protein interaction map reveals NLRP3 inflammasome evasion via MAVS UFMylation. Yiu SPT, Zerbe C, Vanderwall D, Huttlin EL, Weekes MP, Gewurz BE. Mol Cell. 2023 Jul 6;83(13):2367-2386.e15. doi: 10.1016/j.molcel.2023.05.018. Epub 2023 Jun 12. PubMed |
| Structural insights into Siglec-15 reveal glycosylation dependency for its interaction with T cells through integrin CD11b. Lenza MP, Egia-Mendikute L, Antonana-Vildosola A, Soares CO, Coelho H, Corzana F, Bosch A, Manisha P, Quintana JI, Oyenarte I, Unione L, Moure MJ, Azkargorta M, Atxabal U, Sobczak K, Elortza F, Sutherland JD, Barrio R, Marcelo F, Jimenez-Barbero J, Palazon A, Ereno-Orbea J. Nat Commun. 2023 Jun 13;14(1):3496. doi: 10.1038/s41467-023-39119-8. PubMed |
| Preclinical testing of miRNA-193b-3p mimic in acute myeloid leukemias. Issa H, Bhayadia R, Winkler R, Swart LE, Heckl D, Klusmann JH. Leukemia. 2023 Jul;37(7):1583-1587. doi: 10.1038/s41375-023-01937-6. Epub 2023 Jun 13. PubMed |
| Comprehensive functional characterization of SGCB coding variants predicts pathogenicity in limb-girdle muscular dystrophy type R4/2E. Li C, Wilborn J, Pittman S, Daw J, Alonso-Perez J, Diaz-Manera J, Weihl CC, Haller G. J Clin Invest. 2023 Jun 15;133(12):e168156. doi: 10.1172/JCI168156. PubMed |
| A role for microsomal glutathione transferase 1 in melanin biosynthesis and melanoma progression. Zhang J, Ye ZW, Brautigam L, Chakraborty P, Luo Z, Culpepper J, Aslam M, Zhang L, Johansson K, Haeggstrom JZ, Xu J, Olsson M, Townsend DM, Mehrotra S, Morgenstern R, Tew KD. J Biol Chem. 2023 Jun 14;299(8):104920. doi: 10.1016/j.jbc.2023.104920. PubMed |
| Reduced folate carrier 1 is present in retinal microvessels and crucial for the inner blood retinal barrier integrity. Gurler G, Belder N, Beker MC, Sever-Bahcekapili M, Uruk G, Kilic E, Yemisci M. Fluids Barriers CNS. 2023 Jun 16;20(1):47. doi: 10.1186/s12987-023-00442-3. PubMed |
| Glucose Hypometabolism Prompts RAN Translation and Exacerbates C9orf72-related ALS/FTD Phenotypes. Nelson AT, Cicardi ME, Markandaiah SS, Han J, Philp N, Welebob E, Haeusler AR, Pasinelli P, Manfredi G, Kawamata H, Trotti D. bioRxiv. 2023 Jun 7:2023.06.07.544100. doi: 10.1101/2023.06.07.544100. Preprint. PubMed |
| SMYD5 is a novel epigenetic gatekeeper of the mild hypothermia response. Rafnsdottir S, Jang K, Halldorsdottir ST, Tomasdottir A, Vinod M, Moller K, Reynisdottir T, Atladottir LH, Allison KE, He J, Zhang L, Northington FJ, Chavez-Valdez R, Anderson KJ, Bjornsson HT. bioRxiv. 2023 Jun 9:2023.05.11.540170. doi: 10.1101/2023.05.11.540170. Preprint. PubMed |
| The ototoxic drug cisplatin localises to stress granules altering their dynamics and composition. Martin JL, Terry SJ, Gale JE, Dawson SJ. J Cell Sci. 2023 Jul 15;136(14):jcs260590. doi: 10.1242/jcs.260590. Epub 2023 Jul 19. PubMed |
| A multimodal atlas of tumour metabolism reveals the architecture of gene-metabolite covariation. Benedetti E, Liu EM, Tang C, Kuo F, Buyukozkan M, Park T, Park J, Correa F, Hakimi AA, Intlekofer AM, Krumsiek J, Reznik E. Nat Metab. 2023 Jun;5(6):1029-1044. doi: 10.1038/s42255-023-00817-8. Epub 2023 Jun 19. PubMed |
| Inhibition of VEGFR2 and EGFR signaling cooperatively suppresses the proliferation of oral squamous cell carcinoma. Onda M, Ota A, Ito K, Ono T, Karnan S, Kato M, Kondo S, Furuhashi A, Hayashi T, Hosokawa Y, Kazaoka Y. Cancer Med. 2023 Jun 21. doi: 10.1002/cam4.6282. PubMed |
| TRIM21 restricts influenza A virus replication by ubiquitination-dependent degradation of M1. Lin L, Wang X, Chen Z, Deng T, Yan Y, Dong W, Huang Y, Zhou J. PLoS Pathog. 2023 Jun 21;19(6):e1011472. doi: 10.1371/journal.ppat.1011472. eCollection 2023 Jun. PubMed |
| PE-STOP: A versatile tool for installing nonsense substitutions amenable for precise reversion. Song Z, Zhang G, Huang S, Liu Y, Li G, Zhou X, Sun J, Gao P, Chen Y, Huang X, Liu J, Wang X. J Biol Chem. 2023 Aug;299(8):104942. doi: 10.1016/j.jbc.2023.104942. Epub 2023 Jun 19. PubMed |
| Altered hACE2 binding affinity and S1/S2 cleavage efficiency of SARS-CoV-2 spike protein mutants affect viral cell entry. Wang K, Pan Y, Wang D, Yuan Y, Li M, Chen Y, Bi L, Zhang XE. Virol Sin. 2023 Aug;38(4):595-605. doi: 10.1016/j.virs.2023.06.005. Epub 2023 Jun 19. PubMed |
| Micronutrient optimization for tissue engineered articular cartilage production of type II collagen. Cruz MA, Gonzalez Y, Velez Toro JA, Karimzadeh M, Rubbo A, Morris L, Medam R, Splawn T, Archer M, Fernandes RJ, Dennis JE, Kean TJ. Front Bioeng Biotechnol. 2023 Jun 6;11:1179332. doi: 10.3389/fbioe.2023.1179332. eCollection 2023. PubMed |
| Strategic self-limiting production of infectious HIV particles by CRISPR in permissive cells. Liu H, Chen C, Liao S, Sohaii DK, Cruz CRY, Burdo TH, Cradick TJ, Mehta A, Barrero C, Florez M, Gordon J, Grauzam S, Dressman J, Amini S, Bollard CM, Kaminski R, Khalili K. Mol Ther Nucleic Acids. 2023 May 19;32:1010-1025. doi: 10.1016/j.omtn.2023.04.027. eCollection 2023 Jun 13. PubMed |
| Membrane structure and internalization dynamics of human Flower isoforms hFWE3 and hFWE4 indicate a conserved endocytic role for hFWE4. Rudd JC, Maity S, Grunkemeyer JA, Snyder JC, Lovas S, Hansen LA. J Biol Chem. 2023 Jun 20;299(8):104945. doi: 10.1016/j.jbc.2023.104945. PubMed |
| Engineering B cells with customized therapeutic responses using a synthetic circuit. Page A, Delles M, Negre D, Costa C, Fusil F, Cosset FL. Mol Ther Nucleic Acids. 2023 Jun 3;33:1-14. doi: 10.1016/j.omtn.2023.05.024. eCollection 2023 Sep 12. PubMed |
| Preclinical evaluation of chimeric antigen receptor T cells targeting the carcinoembryonic antigen as a potential immunotherapy for gallbladder cancer. Lopez E, Hidalgo S, Roa E, Gomez J, Hermansen Truan C, Sanders E, Carrasco C, Pacheco R, Salazar-Onfray F, Varas-Godoy M, Borgna V, Lladser A. Oncoimmunology. 2023 Jun 22;12(1):2225291. doi: 10.1080/2162402X.2023.2225291. eCollection 2023. PubMed |
| The mitochondrial Ca(2+) channel MCU is critical for tumor growth by supporting cell cycle progression and proliferation. Fernandez Garcia E, Paudel U, Noji MC, Bowman CE, Rustgi AK, Pitarresi JR, Wellen KE, Arany Z, Weissenrieder JS, Foskett JK. Front Cell Dev Biol. 2023 Jun 8;11:1082213. doi: 10.3389/fcell.2023.1082213. eCollection 2023. PubMed |
| Interferon signaling promotes tolerance to chromosomal instability during metastatic evolution in renal cancer. Perelli L, Carbone F, Zhang L, Huang JK, Le C, Khan H, Citron F, Del Poggetto E, Gutschner T, Tomihara H, Soeung M, Minelli R, Srinivasan S, Peoples M, Lam TNA, Lundgren S, Xia R, Zhu C, Mohamed AMT, Zhang J, Sircar K, Sgambato A, Gao J, Jonasch E, Draetta GF, Futreal A, Bakouny Z, Van Allen EM, Choueiri T, Signoretti S, Msaouel P, Litchfield K, Turajlic S, Wang L, Chen YB, Di Natale RG, Hakimi AA, Giuliani V, Heffernan TP, Viale A, Bristow CA, Tannir NM, Carugo A, Genovese G. Nat Cancer. 2023 Jul;4(7):984-1000. doi: 10.1038/s43018-023-00584-1. Epub 2023 Jun 26. PubMed |
| An RNA-immunoprecipitation via CRISPR/dCas13 reveals an interaction between the SARS-CoV-2 5'UTR RNA and the process of human lipid metabolism. Shimizu Y, Bandaru S, Hara M, Young S, Sano T, Usami K, Kurano Y, Lee S, Kumagai-Takei N, Takashiba S, Sano S, Ito T. Sci Rep. 2023 Jun 27;13(1):10413. doi: 10.1038/s41598-023-36680-6. PubMed |
| Effects of the Co-Overexpression of the BCL and BDNF Genes on the Gamma-Aminobutyric Acid-Ergic Differentiation of Wharton's-Jelly-Derived Mesenchymal Stem Cells. Borkowska P, Morys J, Zielinska A, Kowalski J. Biomedicines. 2023 Jun 18;11(6):1751. doi: 10.3390/biomedicines11061751. PubMed |
| Functional Characteristics of Serum Anti-SARS-CoV-2 Antibodies against Delta and Omicron Variants after Vaccination with Sputnik V. Radion EI, Mukhin VE, Kholodova AV, Vladimirov IS, Alsaeva DY, Zhdanova AS, Ulasova NY, Bulanova NV, Makarov VV, Keskinov AA, Yudin SM. Viruses. 2023 Jun 10;15(6):1349. doi: 10.3390/v15061349. PubMed |
| The lipid transfer proteins Nir2 and Nir3 sustain phosphoinositide signaling and actin dynamics during phagocytosis. Kaba M, Carreras-Sureda A, Nunes-Hasler P, Demaurex N. J Cell Sci. 2023 Jul 15;136(14):jcs260902. doi: 10.1242/jcs.260902. Epub 2023 Jul 24. PubMed |
| KLHL7 promotes hepatocellular carcinoma progression and molecular therapy resistance by degrading RASA2. Chen L, Li Y, Chen Y. iScience. 2023 May 19;26(6):106914. doi: 10.1016/j.isci.2023.106914. eCollection 2023 Jun 16. PubMed |
| A single-nucleus transcriptomic atlas of primate liver aging uncovers the pro-senescence role of SREBP2 in hepatocytes. Yang S, Liu C, Jiang M, Liu X, Geng L, Zhang Y, Sun S, Wang K, Yin J, Ma S, Wang S, Belmonte JCI, Zhang W, Qu J, Liu GH. Protein Cell. 2024 Feb 1;15(2):98-120. doi: 10.1093/procel/pwad039. PubMed |
| Anthracyclines inhibit SARS-CoV-2 infection. Wang Z, Pan Q, Ma L, Zhao J, McIntosh F, Liu Z, Ding S, Lin R, Cen S, Finzi A, Liang C. Virus Res. 2023 Sep;334:199164. doi: 10.1016/j.virusres.2023.199164. Epub 2023 Jun 28. PubMed |
| CaMKK2 is not involved in contraction-stimulated AMPK activation and glucose uptake in skeletal muscle. Negoita F, Addinsall AB, Hellberg K, Bringas CF, Hafen PS, Sermersheim TJ, Agerholm M, Lewis CTA, Ahwazi D, Ling NXY, Larsen JK, Deshmukh AS, Hossain MA, Oakhill JS, Ochala J, Brault JJ, Sankar U, Drewry DH, Scott JW, Witczak CA, Sakamoto K. Mol Metab. 2023 Sep;75:101761. doi: 10.1016/j.molmet.2023.101761. Epub 2023 Jun 26. PubMed |
| alpha-catenin interaction with YAP/FoxM1/TEAD-induced CEP55 supports liver cancer cell migration. Tang Y, Thiess L, Weiler SME, Toth M, Rose F, Merker S, Ruppert T, Schirmacher P, Breuhahn K. Cell Commun Signal. 2023 Jun 28;21(1):162. doi: 10.1186/s12964-023-01169-2. PubMed |
The mRNA methyltransferase Mettl3 modulates cytokine mRNA stability and limits functional responses in mast cells.
Leoni C, Bataclan M, Ito-Kureha T, Heissmeyer V, Monticelli S.
Nat Commun. 2023 Jun 29;14(1):3862. doi: 10.1038/s41467-023-39614-y.
PubMed
Associated Plasmids |
| Integrative dissection of gene regulatory elements at base resolution. Chen Z, Javed N, Moore M, Wu J, Sun G, Vinyard M, Collins A, Pinello L, Najm FJ, Bernstein BE. Cell Genom. 2023 Apr 28;3(6):100318. doi: 10.1016/j.xgen.2023.100318. eCollection 2023 Jun 14. PubMed |
| Proteomics of immune cells from liver tumors reveals immunotherapy targets. Canale FP, Neumann J, von Renesse J, Loggi E, Pecoraro M, Vogel I, Zoppi G, Antonini G, Wolf T, Jin W, Zheng X, La Barba G, Birgin E, Forkel M, Nilsson T, Marone R, Mueller H, Pelletier N, Jeker LT, Civenni G, Schlapbach C, Catapano CV, Seifert L, Seifert AM, Gillessen S, De Dosso S, Cristaudi A, Rahbari NN, Ercolani G, Geiger R. Cell Genom. 2023 May 30;3(6):100331. doi: 10.1016/j.xgen.2023.100331. eCollection 2023 Jun 14. PubMed |
| Pharmacological GLUT3 salvage augments the efficacy of vitamin C-induced TET2 restoration in acute myeloid leukemia. Liu J, Min S, Kim D, Park J, Park E, Pei S, Koh Y, Shin DY, Byun JM, Ko M, Yoon SS, Hong J. Leukemia. 2023 Aug;37(8):1638-1648. doi: 10.1038/s41375-023-01954-5. Epub 2023 Jul 1. PubMed |
| Net39 protects muscle nuclei from mechanical stress during the pathogenesis of Emery-Dreifuss muscular dystrophy. Zhang Y, Ramirez-Martinez A, Chen K, McAnally JR, Cai C, Durbacz MZ, Chemello F, Wang Z, Xu L, Bassel-Duby R, Liu N, Olson EN. J Clin Invest. 2023 Jul 3;133(13):e163333. doi: 10.1172/JCI163333. PubMed |
| Common and distinct functions of mouse Dot1l in the regulation of endothelial transcriptome. Yoo H, La H, Park C, Yoo S, Lee H, Song H, Do JT, Choi Y, Hong K. Front Cell Dev Biol. 2023 Jun 15;11:1176115. doi: 10.3389/fcell.2023.1176115. eCollection 2023. PubMed |
| FOXK2 amplification and overexpression promotes breast cancer development and chemoresistance. Yu Y, Cao WM, Cheng F, Shi Z, Han L, Yi JL, da Silva EM, Dopeso H, Chen H, Yang J, Wang X, Zhang C, Zhang H. bioRxiv [Preprint]. 2023 May 30:2023.05.28.542643. doi: 10.1101/2023.05.28.542643. PubMed |
| A GPCR screening in human keratinocytes identifies that the metabolite receptor HCAR3 controls epithelial proliferation, migration, and cellular respiration. Pedro MP, Lund K, Kang SWS, Chen T, Stuelten CH, Porat-Shliom N, Iglesias-Bartolome R. bioRxiv [Preprint]. 2023 May 31:2023.05.30.542853. doi: 10.1101/2023.05.30.542853. PubMed |
| Plasticity-induced repression of Irf6 underlies acquired resistance to cancer immunotherapy. Kim IK, Diamond M, Yuan S, Kemp S, Li Q, Lin J, Li J, Norgard R, Thomas S, Merolle M, Katsuda T, Tobias J, Politi K, Vonderheide R, Stanger B. Res Sq. 2023 Jun 1:rs.3.rs-2960521. doi: 10.21203/rs.3.rs-2960521/v1. Preprint. PubMed |
| Functional glycoproteomics by integrated network assembly and partitioning. Griffin ME, Thompson JW, Xiao Y, Sweredoski MJ, Aksenfeld RB, Jensen EH, Koldobskaya Y, Schacht AL, Kim TD, Choudhry P, Lomenick B, Garbis SD, Moradian A, Hsieh-Wilson LC. bioRxiv. 2023 Jun 14:2023.06.13.541482. doi: 10.1101/2023.06.13.541482. Preprint. PubMed |
| KDM3A and KDM3B Maintain Naive Pluripotency Through the Regulation of Alternative Splicing. Dillingham CM, Cormaty H, Morgan EC, Tak AI, Esgdaille DE, Boutz PL, Sridharan R. bioRxiv [Preprint]. 2024 Jan 23:2023.05.31.543088. doi: 10.1101/2023.05.31.543088. PubMed |
| Myosin 10 uses its MyTH4 and FERM domains differentially to support two aspects of spindle pole biology required for mitotic spindle bipolarity. Yim YI, Pedrosa A, Wu X, Chinthalapudi K, Cheney RE, Hammer JA. bioRxiv [Preprint]. 2023 Jun 15:2023.06.15.545002. doi: 10.1101/2023.06.15.545002. PubMed |
| Prediction of on-target and off-target activity of CRISPR-Cas13d guide RNAs using deep learning. Wessels HH, Stirn A, Mendez-Mancilla A, Kim EJ, Hart SK, Knowles DA, Sanjana NE. Nat Biotechnol. 2023 Jul 3. doi: 10.1038/s41587-023-01830-8. PubMed |
| Genome-wide CRISPR screening reveals ADCK3 as a key regulator in sensitizing endometrial carcinoma cells to MPA therapy. Zhang Z, Zhang M, Zhou J, Wang D. Br J Cancer. 2023 Sep;129(4):601-611. doi: 10.1038/s41416-023-02347-2. Epub 2023 Jul 4. PubMed |
| ATF2 orchestrates macrophage differentiation and activation to promote antibacterial responses. Rajabalee N, Siushansian H, Weerapura M, Berton S, Berbatovci F, Hooks B, Geoffrion M, Yang D, Harper ME, Rayner K, Blais A, Sun J. J Leukoc Biol. 2023 Jul 4:qiad076. doi: 10.1093/jleuko/qiad076. PubMed |
| Melanoma-intrinsic NR2F6 activity regulates antitumor immunity. Kim H, Feng Y, Murad R, Pozniak J, Pelz C, Chen Y, Dalal B, Sears R, Sergienko E, Jackson M, Ruppin E, Herlyn M, Harris C, Marine JC, Klepsch V, Baier G, Ronai ZA. Sci Adv. 2023 Jul 7;9(27):eadf6621. doi: 10.1126/sciadv.adf6621. Epub 2023 Jul 5. PubMed |
| DHODH inhibitors sensitize to ferroptosis by FSP1 inhibition. Mishima E, Nakamura T, Zheng J, Zhang W, Mourao ASD, Sennhenn P, Conrad M. Nature. 2023 Jul;619(7968):E9-E18. doi: 10.1038/s41586-023-06269-0. Epub 2023 Jul 5. PubMed |
| Conversion of Unmodified Stem Cells to Pacemaker Cells by Overexpression of Key Developmental Genes. Karimi T, Pan Z, Potaman VN, Alt EU. Cells. 2023 May 13;12(10):1381. doi: 10.3390/cells12101381. PubMed |
| Hierarchical phosphorylation of HOXB13 by mTOR dictates its activity and oncogenic function in prostate cancer. Chen Y, Dufour CR, Han L, Li T, Xia H, Giguere V. Mol Cancer Res. 2023 Jul 6:MCR-23-0086. doi: 10.1158/1541-7786.MCR-23-0086. PubMed |
| Using Sister Chromatid Exchange Assay to Detect Homologous Recombination Deficiency in Epigenetically Deregulated Urothelial Carcinoma Cells. Rampias T, Klinakis A. Methods Mol Biol. 2023;2684:133-144. doi: 10.1007/978-1-0716-3291-8_7. PubMed |
| The ribosomal protein S6 kinase alpha-1 (RPS6KA1) induces resistance to venetoclax/azacitidine in acute myeloid leukemia. Weidenauer K, Schmidt C, Rohde C, Pauli C, Blank MF, Heid D, Waclawiczek A, Corbacioglu A, Gollner S, Lotze M, Vierbaum L, Renders S, Krijgsveld J, Raffel S, Sauer T, Trumpp A, Pabst C, Muller-Tidow C, Janssen M. Leukemia. 2023 Aug;37(8):1611-1625. doi: 10.1038/s41375-023-01951-8. Epub 2023 Jul 6. PubMed |
| The autophagic protein FYCO1 controls TNFRSF10/TRAIL receptor induced apoptosis and is inactivated by CASP8 (caspase 8). Coppola V, Marino I, Warnken U, Falchi M, Pasquini L, Biffoni M, De Maria R, Haas TL. Autophagy. 2023 Jul 7:1-19. doi: 10.1080/15548627.2023.2229656. PubMed |
| Kinome-wide CRISPR-Cas9 knockout screens revealed PLK1 as a therapeutic target for osteosarcoma. Wang R, Wang D, Bai X, Guo J, Xia S, Cheng Y, Gu Y, Wang Q, Nie J, Chen D, Liu W, Liang J. Cell Death Discov. 2023 Jul 7;9(1):231. doi: 10.1038/s41420-023-01526-7. PubMed |
| Amphetamine disrupts dopamine axon growth in adolescence by a sex-specific mechanism in mice. Reynolds LM, Hernandez G, MacGowan D, Popescu C, Nouel D, Cuesta S, Burke S, Savell KE, Zhao J, Restrepo-Lozano JM, Giroux M, Israel S, Orsini T, He S, Wodzinski M, Avramescu RG, Pokinko M, Epelbaum JG, Niu Z, Pantoja-Urban AH, Trudeau LE, Kolb B, Day JJ, Flores C. Nat Commun. 2023 Jul 7;14(1):4035. doi: 10.1038/s41467-023-39665-1. PubMed |
TMEM106B is a receptor mediating ACE2-independent SARS-CoV-2 cell entry.
Baggen J, Jacquemyn M, Persoons L, Vanstreels E, Pye VE, Wrobel AG, Calvaresi V, Martin SR, Roustan C, Cronin NB, Reading E, Thibaut HJ, Vercruysse T, Maes P, De Smet F, Yee A, Nivitchanyong T, Roell M, Franco-Hernandez N, Rhinn H, Mamchak AA, Ah Young-Chapon M, Brown E, Cherepanov P, Daelemans D.
Cell. 2023 Aug 3;186(16):3427-3442.e22. doi: 10.1016/j.cell.2023.06.005. Epub 2023 Jul 7.
PubMed
Associated Plasmids |
A novel transcription factor combination for direct reprogramming to a spontaneously contracting human cardiomyocyte-like state.
Romero-Tejeda M, Fonoudi H, Weddle CJ, DeKeyser JM, Lenny B, Fetterman KA, Magdy T, Sapkota Y, Epting C, Burridge PW.
J Mol Cell Cardiol. 2023 Jul 6:S0022-2828(23)00106-2. doi: 10.1016/j.yjmcc.2023.06.005.
PubMed
Associated Plasmids |
| Mechanisms controlling membrane recruitment and activation of the autoinhibited SHIP1 inositol 5-phosphatase. Waddell GL, Drew EE, Rupp HP, Hansen SD. J Biol Chem. 2023 Jul 7;299(8):105022. doi: 10.1016/j.jbc.2023.105022. PubMed |
| Co-targeting autophagy and NRF2 signaling triggers mitochondrial superoxide to sensitize oral cancer stem cells for cisplatin-induced apoptosis. Praharaj PP, Singh A, Patra S, Bhutia SK. Free Radic Biol Med. 2023 Jul 7;207:72-88. doi: 10.1016/j.freeradbiomed.2023.07.008. PubMed |
| The interplay of DNA repair context with target sequence predictably biasses Cas9-generated mutations. Pallaseni A, Peets EM, Girling G, Crepaldi L, Kuzmin I, Raudvere U, Peterson H, Sercin O, Mardin BR, Kosicki M, Parts L. bioRxiv. 2023 Jun 28:2023.06.28.546891. doi: 10.1101/2023.06.28.546891. Preprint. PubMed |
| Calcium dysregulation combined with mitochondrial failure and electrophysiological maturity converge in Parkinson's iPSC-dopamine neurons. Beccano-Kelly DA, Cherubini M, Mousba Y, Cramb KML, Giussani S, Caiazza MC, Rai P, Vingill S, Bengoa-Vergniory N, Ng B, Corda G, Banerjee A, Vowles J, Cowley S, Wade-Martins R. iScience. 2023 Jun 7;26(7):107044. doi: 10.1016/j.isci.2023.107044. eCollection 2023 Jul 21. PubMed |
| Engineered MED12 mutations drive leiomyoma-like transcriptional and metabolic programs by altering the 3D genome compartmentalization. Buyukcelebi K, Chen X, Abdula F, Elkafas H, Duval AJ, Ozturk H, Seker-Polat F, Jin Q, Yin P, Feng Y, Bulun SE, Wei JJ, Yue F, Adli M. Nat Commun. 2023 Jul 10;14(1):4057. doi: 10.1038/s41467-023-39684-y. PubMed |
A positively tuned voltage indicator for extended electrical recordings in the brain.
Evans SW, Shi DQ, Chavarha M, Plitt MH, Taxidis J, Madruga B, Fan JL, Hwang FJ, van Keulen SC, Suomivuori CM, Pang MM, Su S, Lee S, Hao YA, Zhang G, Jiang D, Pradhan L, Roth RH, Liu Y, Dorian CC, Reese AL, Negrean A, Losonczy A, Makinson CD, Wang S, Clandinin TR, Dror RO, Ding JB, Ji N, Golshani P, Giocomo LM, Bi GQ, Lin MZ.
Nat Methods. 2023 Jul;20(7):1104-1113. doi: 10.1038/s41592-023-01913-z. Epub 2023 Jul 6.
PubMed
Associated Plasmids |
| Combinatorial targeting of a specific EMT/MET network by macroH2A variants safeguards mesenchymal identity. Valakos D, Klagkou E, Kokkalis A, Polyzos A, Kyrilis FL, Banos A, Vatsellas G, Pliatska M, Ford E, Stravopodis DJ, Thanos D. PLoS One. 2023 Jul 11;18(7):e0288005. doi: 10.1371/journal.pone.0288005. eCollection 2023. PubMed |
| Long noncoding RNA LOC646029 functions as a ceRNA to suppress ovarian cancer progression through the miR-627-3p/SPRED1 axis. Zhao P, Wang Y, Yu X, Nan Y, Liu S, Li B, Cui Z, Liu Z. Front Med. 2023 Jul 12. doi: 10.1007/s11684-023-1004-z. PubMed |
| Dysfunction of ubiquitin protein ligase MYCBP2 leads to cell resilience in human breast cancers. Neff RA, Bosch-Gutierrez A, Sun Y, Katsyv I, Song WM, Wang M, Walsh MJ, Zhang B. NAR Cancer. 2023 Jul 10;5(3):zcad036. doi: 10.1093/narcan/zcad036. eCollection 2023 Sep. PubMed |
| LRP8-mediated selenocysteine uptake is a targetable vulnerability in MYCN-amplified neuroblastoma. Alborzinia H, Chen Z, Yildiz U, Freitas FP, Vogel FCE, Varga JP, Batani J, Bartenhagen C, Schmitz W, Buchel G, Michalke B, Zheng J, Meierjohann S, Girardi E, Espinet E, Florez AF, Dos Santos AF, Aroua N, Cheytan T, Haenlin J, Schlicker L, Xavier da Silva TN, Przybylla A, Zeisberger P, Superti-Furga G, Eilers M, Conrad M, Fabiano M, Schweizer U, Fischer M, Schulze A, Trumpp A, Friedmann Angeli JP. EMBO Mol Med. 2023 Aug 7;15(8):e18014. doi: 10.15252/emmm.202318014. Epub 2023 Jul 12. PubMed |
| SREBP-1 upregulates lipophagy to maintain cholesterol homeostasis in brain tumor cells. Geng F, Zhong Y, Su H, Lefai E, Magaki S, Cloughesy TF, Yong WH, Chakravarti A, Guo D. Cell Rep. 2023 Jul 25;42(7):112790. doi: 10.1016/j.celrep.2023.112790. Epub 2023 Jul 11. PubMed |
| Chemically induced reprogramming to reverse cellular aging. Yang JH, Petty CA, Dixon-McDougall T, Lopez MV, Tyshkovskiy A, Maybury-Lewis S, Tian X, Ibrahim N, Chen Z, Griffin PT, Arnold M, Li J, Martinez OA, Behn A, Rogers-Hammond R, Angeli S, Gladyshev VN, Sinclair DA. Aging (Albany NY). 2023 Jul 12;15(13):5966-5989. doi: 10.18632/aging.204896. Epub 2023 Jul 12. PubMed |
| Deciphering the mitophagy receptor network identifies a crucial role for OPTN (optineurin) in acute myeloid leukemia. Meyer LM, Koschade SE, Vischedyk JB, Thoelken M, Gubas A, Wegner M, Basoglu M, Knapp S, Kaulich M, Eimer S, Shaid S, Brandts CH. Autophagy. 2023 Nov;19(11):2982-2996. doi: 10.1080/15548627.2023.2230839. Epub 2023 Jul 13. PubMed |
| SARS-CoV-2 main protease cleaves MAGED2 to antagonize host antiviral defense. Ju X, Wang Z, Wang P, Ren W, Yu Y, Yu Y, Yuan B, Song J, Zhang X, Zhang Y, Xu C, Tian B, Shi Y, Zhang R, Ding Q. mBio. 2023 Aug 31;14(4):e0137323. doi: 10.1128/mbio.01373-23. Epub 2023 Jul 13. PubMed |
| Expression of low-sulfated keratan sulfate in non-mucinous ovarian carcinoma. Hoshino H, Chen YY, Inoue D, Yoshida Y, Khoo KH, Akama TO, Kobayashi M. Glycobiology. 2023 Jul 13:cwad056. doi: 10.1093/glycob/cwad056. PubMed |
| Extracellular vesicles improve GABAergic transmission in Huntington's disease iPSC-derived neurons. Beatriz M, Rodrigues RJ, Vilaca R, Egas C, Pinheiro PS, Daley GQ, Schlaeger TM, Raimundo N, Rego AC, Lopes C. Theranostics. 2023 Jun 26;13(11):3707-3724. doi: 10.7150/thno.81981. eCollection 2023. PubMed |
Liver lipophagy ameliorates nonalcoholic steatohepatitis through extracellular lipid secretion.
Minami Y, Hoshino A, Higuchi Y, Hamaguchi M, Kaneko Y, Kirita Y, Taminishi S, Nishiji T, Taruno A, Fukui M, Arany Z, Matoba S.
Nat Commun. 2023 Jul 13;14(1):4084. doi: 10.1038/s41467-023-39404-6.
PubMed
Associated Plasmids |
| STING is a cell-intrinsic metabolic checkpoint restricting aerobic glycolysis by targeting HK2. Zhang L, Jiang C, Zhong Y, Sun K, Jing H, Song J, Xie J, Zhou Y, Tian M, Zhang C, Sun X, Wang S, Cheng X, Zhang Y, Wei W, Li X, Fu B, Feng P, Wu B, Shu HB, Zhang J. Nat Cell Biol. 2023 Aug;25(8):1208-1222. doi: 10.1038/s41556-023-01185-x. Epub 2023 Jul 13. PubMed |
| Cathepsin B Is Not an Intrinsic Factor Related to Asparaginase Resistance of the Acute Lymphoblastic Leukemia REH Cell Line. Costa IM, Effer B, Costa-Silva TA, Chen C, Ciccone MF, Pessoa A, Dos Santos CO, Monteiro G. Int J Mol Sci. 2023 Jul 7;24(13):11215. doi: 10.3390/ijms241311215. PubMed |
| Polycomb repressive complex 2 binds and stabilizes NANOG to suppress differentiation-related genes to promote self-renewal. Yeh DW, Liu C, Hernandez JC, Tahara SM, Tsukamoto H, Machida K. iScience. 2023 Jun 7;26(7):107035. doi: 10.1016/j.isci.2023.107035. eCollection 2023 Jul 21. PubMed |
| LKB1 loss promotes colorectal cancer cell metastasis through regulating TNIK expression and actin cytoskeleton remodeling. Hu G, Huang N, Zhang J, Zhang D, Wang S, Zhang Y, Wang L, Du Y, Kuang S, Ma K, Zhu H, Xu N, Liu M. Mol Carcinog. 2023 Jul 14. doi: 10.1002/mc.23606. PubMed |
| RAS-dependent RAF-MAPK hyperactivation by pathogenic RIT1 is a therapeutic target in Noonan syndrome-associated cardiac hypertrophy. Cuevas-Navarro A, Wagner M, Van R, Swain M, Mo S, Columbus J, Allison MR, Cheng A, Messing S, Turbyville TJ, Simanshu DK, Sale MJ, McCormick F, Stephen AG, Castel P. Sci Adv. 2023 Jul 14;9(28):eadf4766. doi: 10.1126/sciadv.adf4766. Epub 2023 Jul 14. PubMed |
| Structural delineation and computational design of SARS-CoV-2-neutralizing antibodies against Omicron subvariants. Moriyama S, Anraku Y, Taminishi S, Adachi Y, Kuroda D, Kita S, Higuchi Y, Kirita Y, Kotaki R, Tonouchi K, Yumoto K, Suzuki T, Someya T, Fukuhara H, Kuroda Y, Yamamoto T, Onodera T, Fukushi S, Maeda K, Nakamura-Uchiyama F, Hashiguchi T, Hoshino A, Maenaka K, Takahashi Y. Nat Commun. 2023 Jul 14;14(1):4198. doi: 10.1038/s41467-023-39890-8. PubMed |
| Gain-of-function p53(R175H) blocks apoptosis in a precursor model of ovarian high-grade serous carcinoma. Haagsma J, Kolendowski B, Buensuceso A, Valdes YR, DiMattia GE, Shepherd TG. Sci Rep. 2023 Jul 14;13(1):11424. doi: 10.1038/s41598-023-38609-5. PubMed |
| The mitophagy receptor NIX induces vIRF-1 oligomerization and interaction with GABARAPL1 for the promotion of HHV-8 reactivation-induced mitophagy. Vo MT, Choi CY, Choi YB. PLoS Pathog. 2023 Jul 17;19(7):e1011548. doi: 10.1371/journal.ppat.1011548. eCollection 2023 Jul. PubMed |
| Mannose antagonizes GSDME-mediated pyroptosis through AMPK activated by metabolite GlcNAc-6P. Ai YL, Wang WJ, Liu FJ, Fang W, Chen HZ, Wu LZ, Hong X, Zhu Y, Zhang CX, Liu LY, Hong WB, Zhou B, Chen QT, Wu Q. Cell Res. 2023 Jul 17. doi: 10.1038/s41422-023-00848-6. PubMed |
| Structures of p53/BCL-2 complex suggest a mechanism for p53 to antagonize BCL-2 activity. Wei H, Wang H, Wang G, Qu L, Jiang L, Dai S, Chen X, Zhang Y, Chen Z, Li Y, Guo M, Chen Y. Nat Commun. 2023 Jul 18;14(1):4300. doi: 10.1038/s41467-023-40087-2. PubMed |
| Parkin regulates amino acid homeostasis at mitochondria-lysosome (M/L) contact sites in Parkinson's disease. Peng W, Schroder LF, Song P, Wong YC, Krainc D. Sci Adv. 2023 Jul 21;9(29):eadh3347. doi: 10.1126/sciadv.adh3347. Epub 2023 Jul 19. PubMed |
The SUMO-NIP45 pathway processes toxic DNA catenanes to prevent mitotic failure.
Hertz EPT, Vega IA, Kruse T, Wang Y, Hendriks IA, Bizard AH, Eugui-Anta A, Hay RT, Nielsen ML, Nilsson J, Hickson ID, Mailand N.
Nat Struct Mol Biol. 2023 Jul 20. doi: 10.1038/s41594-023-01045-0.
PubMed
Associated Plasmids |
| Targeting polyploid giant cancer cells potentiates a therapeutic response and overcomes resistance to PARP inhibitors in ovarian cancer. Zhang X, Yao J, Li X, Niu N, Liu Y, Hajek RA, Peng G, Westin S, Sood AK, Liu J. Sci Adv. 2023 Jul 21;9(29):eadf7195. doi: 10.1126/sciadv.adf7195. Epub 2023 Jul 21. PubMed |
| Radio-immunotherapy by (188)Re-antiCD20 and stable silencing of IGF-IR in Raji cells, new insight in treatment of lymphoma. Nasehi L, Abdolhossein Zadeh B, Rahimi H, Hossein Ghahremani M. Gene. 2023 Oct 5;882:147638. doi: 10.1016/j.gene.2023.147638. Epub 2023 Jul 20. PubMed |
| H3K27me3 of Rnf19a promotes neuroinflammatory response during Japanese encephalitis virus infection. Zhu S, Tao M, Li Y, Wang X, Zhao Z, Liu Y, Li Q, Li Q, Lu Y, Si Y, Cao S, Ye J. J Neuroinflammation. 2023 Jul 21;20(1):168. doi: 10.1186/s12974-023-02852-4. PubMed |
| Long non-coding RNA CCHE1 modulates LDHA-mediated glycolysis and confers chemoresistance to melanoma cells. Ding Z, Yang J, Wu B, Wu Y, Guo F. Cancer Metab. 2023 Jul 21;11(1):10. doi: 10.1186/s40170-023-00309-z. PubMed |
| Lipoylation is dependent on the ferredoxin FDX1 and dispensable under hypoxia in human cells. Joshi PR, Sadre S, Guo XA, McCoy JG, Mootha VK. J Biol Chem. 2023 Jul 20:105075. doi: 10.1016/j.jbc.2023.105075. PubMed |
| The anti-SARS-CoV-2 effect and mechanism of Chiehyuan herbal oral protection solution. Wu CY, Yang YH, Lin YS, Shu LH, Cheng YC, Liu HT, Lin YY, Lee IY, Shih WT, Yang PR, Tsai YY, Chang GH, Hsu CM, Yeh RA, Wu YH, Wu YH, Shen RC, Tsai MS. Heliyon. 2023 Jul 3;9(7):e17701. doi: 10.1016/j.heliyon.2023.e17701. eCollection 2023 Jul. PubMed |
| NAT10-mediated RNA acetylation enhances HNRNPUL1 mRNA stability to contribute cervical cancer progression. Long Y, Ren Y, Wei Q, Mobet Y, Liu Y, Zhao H, Liu T, Cheng L, Yi P. Int J Med Sci. 2023 Jun 26;20(8):1079-1090. doi: 10.7150/ijms.83828. eCollection 2023. PubMed |
| Autonomous action and cooperativity between the ONECUT2 transcription factor and its 3' untranslated region. Steadman K, You S, Srinivas DV, Mouakkad L, Yan Y, Kim M, Venugopal SV, Tanaka H, Freeman MR. Front Cell Dev Biol. 2023 Jul 5;11:1206259. doi: 10.3389/fcell.2023.1206259. eCollection 2023. PubMed |
| Upregulation of Somatostatin Receptor Type 2 Improves 177Lu-DOTATATE Therapy in Receptor-Deficient Pancreatic Neuroendocrine Tumor Model. Sharma R, Earla B, Baidoo KE, Zeiger MA, Madigan JP, Escorcia FE, Sadowski SM. Mol Cancer Ther. 2023 Jul 22:MCT-22-0798. doi: 10.1158/1535-7163.MCT-22-0798. PubMed |
| Functional annotation of variants of the BRCA2 gene via locally haploid human pluripotent stem cells. Li H, Bartke R, Zhao L, Verma Y, Horacek A, Rechav Ben-Natan A, Pangilinan GR, Krishnappa N, Nielsen R, Hockemeyer D. Nat Biomed Eng. 2023 Jul 24. doi: 10.1038/s41551-023-01065-7. PubMed |
| Cas phosphorylation regulates focal adhesion assembly. Kumar S, Stainer A, Dubrulle J, Simpkins C, Cooper JA. Elife. 2023 Jul 25;12:e90234. doi: 10.7554/eLife.90234. PubMed |
| microRNAs slow translating ribosomes to prevent protein misfolding in eukaryotes. Sako H, Youssef M, Elisseeva O, Akimoto T, Suzuki K, Ushida T, Yamamoto T. EMBO J. 2023 Jul 26:e112469. doi: 10.15252/embj.2022112469. PubMed |
| CBF-Beta Mitigates PI3K-Alpha-Specific Inhibitor Killing through PIM1 in PIK3CA-Mutant Gastric Cancer. Stanland LJ, Ang HX, Hoj JP, Chu Y, Tan P, Wood KC, Luftig MA. Mol Cancer Res. 2023 Nov 1;21(11):1148-1162. doi: 10.1158/1541-7786.MCR-23-0034. PubMed |
| Structural homology screens reveal host-derived poxvirus protein families impacting inflammasome activity. Boys IN, Johnson AG, Quinlan MR, Kranzusch PJ, Elde NC. Cell Rep. 2023 Aug 29;42(8):112878. doi: 10.1016/j.celrep.2023.112878. Epub 2023 Jul 25. PubMed |
| T Cells Expressing CAR Equipped With Extracellular Domain of BTLA Are Effective Against HVEM-over-expressing Melanoma Cell Lines. Kim Y, Kim JE, Lee DY, Choi JU, Park JS, Lee HK, Choi SU, Park S, Park CH. Anticancer Res. 2023 Aug;43(8):3419-3427. doi: 10.21873/anticanres.16517. PubMed |
| Exposure of iPSC-derived human microglia to brain substrates enables the generation and manipulation of diverse transcriptional states in vitro. Dolan MJ, Therrien M, Jereb S, Kamath T, Gazestani V, Atkeson T, Marsh SE, Goeva A, Lojek NM, Murphy S, White CM, Joung J, Liu B, Limone F, Eggan K, Hacohen N, Bernstein BE, Glass CK, Leinonen V, Blurton-Jones M, Zhang F, Epstein CB, Macosko EZ, Stevens B. Nat Immunol. 2023 Aug;24(8):1382-1390. doi: 10.1038/s41590-023-01558-2. Epub 2023 Jul 27. PubMed |
| Protein arginine methyltransferase 5 (PRMT5) is an actionable therapeutic target in CDK4/6 inhibitor-resistant ER+/RB-deficient breast cancer. Lin CC, Chang TC, Wang Y, Guo L, Gao Y, Bikorimana E, Lemoff A, Fang Y, Zhang H, Zhang Y, Ye D, Soria-Bretones I, Servetto A, Lee KM, Luo X, Otto J, Akamatsu H, Napolitano F, Mani R, Cescon D, Xu L, Xie Y, Mendell J, Hanker A, Arteaga C. Res Sq. 2023 Jul 10:rs.3.rs-2966905. doi: 10.21203/rs.3.rs-2966905/v1. Preprint. PubMed |
| NSD2 maintains lineage plasticity and castration-resistance in neuroendocrine prostate cancer. Li JJ, Vasciaveo A, Karagiannis D, Sun Z, Chen X, Socciarelli F, Frankenstein Z, Zou M, Pannellini T, Chen Y, Gardner K, Robinson BD, de Bono J, Abate-Shen C, Rubin MA, Loda M, Sawyers CL, Califano A, Lu C, Shen MM. bioRxiv. 2023 Jul 19:2023.07.18.549585. doi: 10.1101/2023.07.18.549585. Preprint. PubMed |
| Tumor-intrinsic LKB1-LIF signaling axis establishes a myeloid niche to promote immune evasion and tumor growth. Rashidfarrokhi A, Pillai R, Hao Y, Wu WL, Karadal-Ferrena B, Dimitriadoy SG, Cross M, Yeaton AH, Huang SM, Bhutkar AJ, Herrera A, Rajalingam S, Hayashi M, Huang KL, Bartnicki E, Zavitsanou AM, Wohlhieter CA, Leboeuf SE, Chen T, Loomis C, Mezzano V, Kulicke R, Davis FP, Stransky N, Smolen GA, Rudin CM, Moreira AL, Khanna KM, Pass HI, Wong KK, Koide S, Tsirigos A, Koralov SB, Papagiannakopoulos T. bioRxiv. 2023 Jul 17:2023.07.15.549147. doi: 10.1101/2023.07.15.549147. Preprint. PubMed |
| The Septin Cytoskeleton is Required for Plasma Membrane Repair. Prislusky MI, Lam JG, Contreras VR, Ng M, Chamberlain M, Fields M, Zhang X, Amer AO, Seveau S. bioRxiv. 2023 Jul 12:2023.07.12.548547. doi: 10.1101/2023.07.12.548547. Preprint. PubMed |
| High-throughput functional dissection of noncoding SNPs with biased allelic enhancer activity for insulin resistance-relevant phenotypes. Duan YY, Chen XF, Zhu RJ, Jia YY, Huang XT, Zhang M, Yang N, Dong SS, Zeng M, Feng Z, Zhu DL, Wu H, Jiang F, Shi W, Hu WX, Ke X, Chen H, Liu Y, Jing RH, Guo Y, Li M, Yang TL. Am J Hum Genet. 2023 Aug 3;110(8):1266-1288. doi: 10.1016/j.ajhg.2023.07.002. Epub 2023 Jul 27. PubMed |
| Integrative CRISPR Activation and Small Molecule Inhibitor Screening for lncRNA Mediating BRAF Inhibitor Resistance in Melanoma. Shamloo S, Kloetgen A, Petroulia S, Hockemeyer K, Sievers S, Tsirigos A, Aifantis I, Imig J. Biomedicines. 2023 Jul 21;11(7):2054. doi: 10.3390/biomedicines11072054. PubMed |
| Differential Inhibition of Anaplerotic Pyruvate Carboxylation and Glutaminolysis-Fueled Anabolism Underlies Distinct Toxicity of Selenium Agents in Human Lung Cancer. Fan TW, Winnike J, Al-Attar A, Belshoff AC, Lorkiewicz PK, Tan JL, Wu M, Higashi RM, Lane AN. Metabolites. 2023 Jun 21;13(7):774. doi: 10.3390/metabo13070774. PubMed |
| Genome-wide screening for regulators of degradation of insulin secretory granules with a fluorescent reporter. Kanai A, Nishida Y, Iwamoto T, Yokota M, Aoyama S, Ueki K, Ito M, Uzawa H, Iida H, Koike M, Watada H. Biochem Biophys Res Commun. 2023 Jul 20;676:132-140. doi: 10.1016/j.bbrc.2023.07.040. PubMed |
| Dual role of the adhesion G-protein coupled receptor ADRGE5/CD97 in glioblastoma invasion and proliferation. Slepak TI, Guyot M, Walters W, Eichberg DG, Ivan ME. J Biol Chem. 2023 Jul 28:105105. doi: 10.1016/j.jbc.2023.105105. PubMed |
Development of a V5-tag-directed nanobody and its implementation as an intracellular biosensor of GPCR signalling.
Zeghal M, Matte K, Venes A, Patel S, Laroche G, Sarvan S, Joshi M, Rain JC, Couture JF, Giguere PM.
J Biol Chem. 2023 Jul 28:105107. doi: 10.1016/j.jbc.2023.105107.
PubMed
Associated Plasmids |
Knockout of all ErbB-family genes delineates their roles in proliferation, survival, and migration.
Matsuda K, Hirayama D, Hino N, Kuno S, Sakaue-Sawano A, Miyawaki A, Matsuda M, Terai K.
J Cell Sci. 2023 Jul 31:jcs.261199. doi: 10.1242/jcs.261199.
PubMed
Associated Plasmids |
| Rational engineering of an improved adenosine deaminase 2 enzyme for weaponizing T-cell therapies. Cox JR, Jennings M, Lenahan C, Manion M, Courville S, Blazeck J. Immunooncol Technol. 2023 Jun 28;19:100394. doi: 10.1016/j.iotech.2023.100394. eCollection 2023 Sep. PubMed |
| MAVS Antagonizes Human Stem Cell Senescence as a Mitochondrial Stabilizer. Wang C, Yang K, Liu X, Wang S, Song M, Belmonte JCI, Qu J, Liu GH, Zhang W. Research (Wash D C). 2023 Jul 27;6:0192. doi: 10.34133/research.0192. eCollection 2023. PubMed |
| PD1 is transcriptionally regulated by LEF1 in mature T cells. Zhao P, Sun L, Zhao C, Malik S. Immunobiology. 2023 Jul 20;228(5):152708. doi: 10.1016/j.imbio.2023.152708. PubMed |
| Extra centrosomes induce PIDD1-mediated inflammation and immunosurveillance. Garcia-Carpio I, Braun VZ, Weiler ES, Leone M, Ninerola S, Barco A, Fava LL, Villunger A. EMBO J. 2023 Aug 2:e113510. doi: 10.15252/embj.2023113510. PubMed |
| The cell cycle protein MAD2 facilitates endocytosis of the serotonin transporter in the neuronal soma. Koban F, Freissmuth M. EMBO Rep. 2023 Oct 9;24(10):e53408. doi: 10.15252/embr.202153408. Epub 2023 Aug 2. PubMed |
| Skp2-mediated MLKL degradation confers cisplatin-resistant in non-small cell lung cancer cells. Zhou H, Zhou L, Guan Q, Hou X, Wang C, Liu L, Wang J, Yu X, Li W, Liu H. Commun Biol. 2023 Aug 2;6(1):805. doi: 10.1038/s42003-023-05166-6. PubMed |
| CD8(+) T cells maintain killing of MHC-I-negative tumor cells through the NKG2D-NKG2DL axis. Lerner EC, Woroniecka KI, D'Anniballe VM, Wilkinson DS, Mohan AA, Lorrey SJ, Waibl-Polania J, Wachsmuth LP, Miggelbrink AM, Jackson JD, Cui X, Raj JA, Tomaszewski WH, Cook SL, Sampson JH, Patel AP, Khasraw M, Gunn MD, Fecci PE. Nat Cancer. 2023 Sep;4(9):1258-1272. doi: 10.1038/s43018-023-00600-4. Epub 2023 Aug 3. PubMed |
| Ribosome subunit attrition and activation of the p53-MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition. Howard GC, Wang J, Rose KL, Jones C, Patel P, Tsui T, Florian AC, Vlach L, Lorey SL, Grieb BC, Smith BN, Slota MJ, Reynolds EM, Goswami S, Savona MR, Mason FM, Lee T, Fesik SW, Liu Q, Tansey WP. bioRxiv [Preprint]. 2024 Jan 10:2023.07.26.550648. doi: 10.1101/2023.07.26.550648. PubMed |
| A genome-wide single-cell 3D genome atlas of lung cancer progression. Liu M, Jin S, Agabiti SS, Jensen TB, Yang T, Radda JSD, Ruiz CF, Baldissera G, Muzumdar MD, Wang S. bioRxiv [Preprint]. 2023 Jul 24:2023.07.23.550157. doi: 10.1101/2023.07.23.550157. PubMed |
| Analysis of the complex between MBD2 and the histone deacetylase core of NuRD reveals key interactions critical for gene silencing. Leighton GO, Shang S, Hageman S, Ginder GD, Williams DC Jr. Proc Natl Acad Sci U S A. 2023 Aug 15;120(33):e2307287120. doi: 10.1073/pnas.2307287120. Epub 2023 Aug 8. PubMed |
| Inactivating TDP2 missense mutation in siblings with congenital abnormalities reminiscent of fanconi anemia. Zagnoli-Vieira G, Brazina J, Van Den Bogaert K, Huybrechts W, Molenaers G, Caldecott KW, Van Esch H. Hum Genet. 2023 Sep;142(9):1417-1427. doi: 10.1007/s00439-023-02589-3. Epub 2023 Aug 10. PubMed |
| ER-associated degradation in cystinosis pathogenesis and the prospects of precision medicine. Venkatarangan V, Zhang W, Yang X, Thoene J, Hahn SH, Li M. J Clin Invest. 2023 Oct 2;133(19):e169551. doi: 10.1172/JCI169551. PubMed |
| RXR Agonists Enhance Lenalidomide Anti-Myeloma Activity and T Cell Functions while Retaining Glucose-Lowering Effect. Wu J, Wang X, Zhang M, Mathews P, Kang Y. Cells. 2023 Aug 3;12(15):1993. doi: 10.3390/cells12151993. PubMed |
| Establishment and Molecular Characterization of an In Vitro Model for PARPi-Resistant Ovarian Cancer. Klotz DM, Schwarz FM, Dubrovska A, Schuster K, Theis M, Kruger A, Kutz O, Link T, Wimberger P, Drukewitz S, Buchholz F, Thomale J, Kuhlmann JD. Cancers (Basel). 2023 Jul 25;15(15):3774. doi: 10.3390/cancers15153774. PubMed |
| Elafin as a Prognostic Marker in Esophageal Squamous Cell Carcinoma: A Pilot Study Using Three-Dimensional Imaging and Genomic Profiling. Chen WC, Wu CC, Liu YP, Zhuo GY, Wang YK, Chen YH, Chen CC, Wang YH, Wu MT, Wu IC. Cancers (Basel). 2023 Jul 27;15(15):3825. doi: 10.3390/cancers15153825. PubMed |
| MSC.sensor: Capturing cancer cell interactions with stroma for functional profiling. Huang Y, Drakul A, Sidhu J, Rauwolf KK, Kim J, Bornhauser B, Bourquin JP. SLAS Discov. 2023 Aug 11:S2472-5552(23)00061-8. doi: 10.1016/j.slasd.2023.08.003. PubMed |
| Downregulation of DNA methylation enhances differentiation of THP-1 cells and induces M1 polarization of differentiated macrophages. Park J, Luo Y, Park JW, Kim SH, Hong YJ, Lim Y, Seo YJ, Bae J, Seo SB. Sci Rep. 2023 Aug 12;13(1):13132. doi: 10.1038/s41598-023-40362-8. PubMed |
| A Size Filter Regulates Apical Protein Sorting. de Caestecker C, Macara IG. Res Sq [Preprint]. 2023 Aug 4:rs.3.rs-3210598. doi: 10.21203/rs.3.rs-3210598/v1. PubMed |
| Mis-splicing Drives Loss of Function of p53(E224D) Point Mutation. Lock IC, Leisenring NH, Floyd W, Xu ES, Luo L, Ma Y, Mansell EC, Cardona DM, Lee CL, Kirsch DG. bioRxiv [Preprint]. 2023 Aug 3:2023.08.01.551439. doi: 10.1101/2023.08.01.551439. PubMed |
PTEN deficiency exposes a requirement for an ARF GTPase module for integrin-dependent invasion in ovarian cancer.
Nikolatou K, Sandilands E, Roman-Fernandez A, Cumming EM, Freckmann E, Lilla S, Buetow L, McGarry L, Neilson M, Shaw R, Strachan D, Miller C, Huang DT, McNeish IA, Norman JC, Zanivan S, Bryant DM.
EMBO J. 2023 Sep 18;42(18):e113987. doi: 10.15252/embj.2023113987. Epub 2023 Aug 14.
PubMed
Associated Plasmids |
| Parkin Deficiency Suppresses Antigen Presentation to Promote Tumor Immune Evasion and Immunotherapy Resistance. Perales-Linares R, Leli NM, Mohei H, Beghi S, Rivera OD, Kostopoulos N, Giglio A, George SS, Uribe-Herranz M, Costabile F, Pierini S, Pustylnikov S, Skoufos G, Barash Y, Hatzigeorgiou AG, Koumenis C, Maity A, Lotze MT, Facciabene A. Cancer Res. 2023 Nov 1;83(21):3562-3576. doi: 10.1158/0008-5472.CAN-22-2499. PubMed |
| In vivo screening characterizes chromatin factor functions during normal and malignant hematopoiesis. Lara-Astiaso D, Goni-Salaverri A, Mendieta-Esteban J, Narayan N, Del Valle C, Gross T, Giotopoulos G, Beinortas T, Navarro-Alonso M, Aguado-Alvaro LP, Zazpe J, Marchese F, Torrea N, Calvo IA, Lopez CK, Alignani D, Lopez A, Saez B, Taylor-King JP, Prosper F, Fortelny N, Huntly BJP. Nat Genet. 2023 Sep;55(9):1542-1554. doi: 10.1038/s41588-023-01471-2. Epub 2023 Aug 14. PubMed |
| Novel competitive enzyme-linked immunosorbent assay for the detection of the high-risk Human Papillomavirus 18 E6 oncoprotein. Contreras NE, Roldan JS, Castillo DS. PLoS One. 2023 Aug 15;18(8):e0290088. doi: 10.1371/journal.pone.0290088. eCollection 2023. PubMed |
| Boosting NAD preferentially blunts Th17 inflammation via arginine biosynthesis and redox control in healthy and psoriasis subjects. Han K, Singh K, Meadows AM, Sharma R, Hassanzadeh S, Wu J, Goss-Holmes H, Huffstutler RD, Teague HL, Mehta NN, Griffin JL, Tian R, Traba J, Sack MN. Cell Rep Med. 2023 Sep 19;4(9):101157. doi: 10.1016/j.xcrm.2023.101157. Epub 2023 Aug 15. PubMed |
| Pharmacological perturbation of the phase-separating protein SMNDC1. Enders L, Siklos M, Borggrafe J, Gaussmann S, Koren A, Malik M, Tomek T, Schuster M, Reinis J, Hahn E, Rukavina A, Reicher A, Casteels T, Bock C, Winter GE, Hannich JT, Sattler M, Kubicek S. Nat Commun. 2023 Aug 16;14(1):4504. doi: 10.1038/s41467-023-40124-0. PubMed |
KDM6A epigenetically regulates subtype plasticity in small cell lung cancer.
Duplaquet L, Li Y, Booker MA, Xie Y, Olsen SN, Patel RA, Hong D, Hatton C, Denize T, Walton E, Laimon YN, Li R, Jiang Y, Bronson RT, Southard J, Li S, Signoretti S, Qiu X, Cejas P, Armstrong SA, Long HW, Tolstorukov MY, Haffner MC, Oser MG.
Nat Cell Biol. 2023 Sep;25(9):1346-1358. doi: 10.1038/s41556-023-01210-z. Epub 2023 Aug 17.
PubMed
Associated Plasmids |
| XAF1 promotes anti-RNA virus immune responses by regulating chromatin accessibility. Kuang M, Zhao Y, Yu H, Li S, Liu T, Chen L, Chen J, Luo Y, Guo X, Wei X, Li Y, Zhang Z, Wang D, You F. Sci Adv. 2023 Aug 18;9(33):eadg5211. doi: 10.1126/sciadv.adg5211. Epub 2023 Aug 18. PubMed |
| TIGIT can inhibit T cell activation via ligation-induced nanoclusters, independent of CD226 co-stimulation. Worboys JD, Vowell KN, Hare RK, Ambrose AR, Bertuzzi M, Conner MA, Patel FP, Zammit WH, Gali-Moya J, Hazime KS, Jones KL, Rey C, Jonjic S, Rovis TL, Tannahill GM, Cruz De Matos GDS, Waight JD, Davis DM. Nat Commun. 2023 Aug 18;14(1):5016. doi: 10.1038/s41467-023-40755-3. PubMed |
Evaluation of the determinants for improved pluripotency induction and maintenance by engineered SOX17.
Hu H, Ho DHH, Tan DS, MacCarthy CM, Yu CH, Weng M, Scholer HR, Jauch R.
Nucleic Acids Res. 2023 Aug 23:gkad597. doi: 10.1093/nar/gkad597.
PubMed
Associated Plasmids |
| FGF1 supports glycolytic metabolism through the estrogen receptor in endocrine-resistant and obesity-associated breast cancer. Castillo-Castrejon M, Sankofi BM, Murguia SJ, Udeme AA, Cen HH, Xia YH, Thomas NS, Berry WL, Jones KL, Richard VR, Zahedi RP, Borchers CH, Johnson JD, Wellberg EA. Breast Cancer Res. 2023 Aug 22;25(1):99. doi: 10.1186/s13058-023-01699-0. PubMed |
| A genome-wide atlas of human cell morphology. Ramezani M, Bauman J, Singh A, Weisbart E, Yong J, Lozada M, Way GP, Kavari SL, Diaz C, Haghighi M, Batista TM, Perez-Schindler J, Claussnitzer M, Singh S, Cimini BA, Blainey PC, Carpenter AE, Jan CH, Neal JT. bioRxiv [Preprint]. 2023 Aug 7:2023.08.06.552164. doi: 10.1101/2023.08.06.552164. PubMed |
| SUMOylation of the m6A reader YTHDF2 by PIAS1 promotes viral RNA decay to restrict EBV replication. Sugiokto FG, Saiada F, Zhang K, Li R. bioRxiv [Preprint]. 2023 Aug 9:2023.08.08.552509. doi: 10.1101/2023.08.08.552509. PubMed |
An engineered Sox17 induces somatic to neural stem cell fate transitions independently from pluripotency reprogramming.
Weng M, Hu H, Graus MS, Tan DS, Gao Y, Ren S, Ho DHH, Langer J, Holzner M, Huang Y, Ling GS, Lai CSW, Francois M, Jauch R.
Sci Adv. 2023 Aug 25;9(34):eadh2501. doi: 10.1126/sciadv.adh2501. Epub 2023 Aug 23.
PubMed
Associated Plasmids |
| CRISPR/dCAS9-mediated DNA demethylation screen identifies functional epigenetic determinants of colorectal cancer. Tejedor JR, Penarroya A, Gancedo-Verdejo J, Santamarina-Ojeda P, Perez RF, Lopez-Tamargo S, Diez-Borge A, Alba-Linares JJ, Gonzalez-Del-Rey N, Urdinguio RG, Mangas C, Roberti A, Lopez V, Morales-Ruiz T, Ariza RR, Roldan-Arjona T, Meijon M, Valledor L, Canal MJ, Fernandez-Martinez D, Fernandez-Hevia M, Jimenez-Fonseca P, Garcia-Florez LJ, Fernandez AF, Fraga MF. Clin Epigenetics. 2023 Aug 24;15(1):133. doi: 10.1186/s13148-023-01546-1. PubMed |
Circadian clock regulator Bmal1 gates axon regeneration via Tet3 epigenetics in mouse sensory neurons.
Halawani D, Wang Y, Ramakrishnan A, Estill M, He X, Shen L, Friedel RH, Zou H.
Nat Commun. 2023 Aug 24;14(1):5165. doi: 10.1038/s41467-023-40816-7.
PubMed
Associated Plasmids |
| Cancer-cell-secreted miR-204-5p induces leptin signalling pathway in white adipose tissue to promote cancer-associated cachexia. Hu Y, Liu L, Chen Y, Zhang X, Zhou H, Hu S, Li X, Li M, Li J, Cheng S, Liu Y, Xu Y, Yan W. Nat Commun. 2023 Aug 24;14(1):5179. doi: 10.1038/s41467-023-40571-9. PubMed |
| RNAPII-dependent ATM signaling at collisions with replication forks. Einig E, Jin C, Andrioletti V, Macek B, Popov N. Nat Commun. 2023 Aug 24;14(1):5147. doi: 10.1038/s41467-023-40924-4. PubMed |
| Targeted inhibition of protein synthesis renders cancer cells vulnerable to apoptosis by unfolded protein response. Gsottberger F, Meier C, Ammon A, Parker S, Wendland K, George R, Petkovic S, Mellenthin L, Emmerich C, Lutzny-Geier G, Metzler M, Mackensen A, Chandramohan V, Muller F. Cell Death Dis. 2023 Aug 26;14(8):561. doi: 10.1038/s41419-023-06055-w. PubMed |
| Structural and functional insights into the modulation of T cell costimulation by monkeypox virus protein M2. Yang S, Wang Y, Yu F, Cheng R, Zhang Y, Zhou D, Ren X, Deng Z, Zhao H. Nat Commun. 2023 Aug 25;14(1):5186. doi: 10.1038/s41467-023-40748-2. PubMed |
| Ado-Mediated Depletion of Taurine Impairs Mitochondrial Respiratory Capacity and Alters the Chromatin Landscape of Inguinal Adipose Tissue. Tsai PY, Shui B, Lee S, Liu Y, Qu Y, Cheng C, Edwards K, Wong C, Meng-Killeen R, Soloway PD, Barrow JJ. Nutrients. 2023 Aug 11;15(16):3532. doi: 10.3390/nu15163532. PubMed |
| Phenothiazines Inhibit SARS-CoV-2 Entry through Targeting Spike Protein. Liang T, Xiao S, Wu Z, Lv X, Liu S, Hu M, Li G, Li P, Ma X. Viruses. 2023 Jul 31;15(8):1666. doi: 10.3390/v15081666. PubMed |
| Testicular germ cell tumour cells release microRNA-containing extracellular vesicles that induce phenotypic and genotypic changes in cells of the tumour microenvironment. Alonso-Crisostomo L, Trendell J, Ferraresso M, Bailey S, Ward D, Scurlock ZGL, Wenlock SC, Bastos CAP, Jugdaohsingh R, Faria NJ, Enright AJ, Scarpini CG, Coleman N, Murray MJ. Int J Cancer. 2024 Jan 15;154(2):372-388. doi: 10.1002/ijc.34697. Epub 2023 Aug 26. PubMed |
| LncRNA GAS5-hnRNPK axis inhibited ovarian cancer progression via inhibition of AKT signaling in ovarian cancer cells. Zhang T, Leng Y, Duan M, Li Z, Ma Y, Huang C, Shi Q, Wang Y, Wang C, Liu D, Zhao X, Cheng S, Liu A, Zhou Y, Liu J, Pan Z, Zhang H, Shen L, Zhao H. Discov Oncol. 2023 Aug 28;14(1):157. doi: 10.1007/s12672-023-00764-6. PubMed |
| SARS-CoV-2 spike protein induces endothelial inflammation via ACE2 independently of viral replication. Montezano AC, Camargo LL, Mary S, Neves KB, Rios FJ, Stein R, Lopes RA, Beattie W, Thomson J, Herder V, Szemiel AM, McFarlane S, Palmarini M, Touyz RM. Sci Rep. 2023 Aug 28;13(1):14086. doi: 10.1038/s41598-023-41115-3. PubMed |
| Bioluminescence Assay of Lysine Deacylase Sirtuin Activity. Van Scoyk AN, Antelope O, Franzini A, Ayer DE, Peterson RT, Pomicter AD, Owen SC, Deininger MW. bioRxiv [Preprint]. 2023 Aug 14:2023.08.10.552871. doi: 10.1101/2023.08.10.552871. PubMed |
| Characterization of enhancer activity in early human neurodevelopment using Massively parallel reporter assay (MPRA) and forebrain organoids. Capauto D, Wang Y, Wu F, Norton S, Mariani J, Inoue F, Crawford GE, Ahituv N, Abyzov A, Vaccarino FM. bioRxiv [Preprint]. 2023 Aug 14:2023.08.14.553170. doi: 10.1101/2023.08.14.553170. PubMed |
| Mechanical force regulates ligand binding and function of PD-1. Li K, Cardenas-Lizana P, Kellner AV, Yuan Z, Ahn E, Lyu J, Li Z, Salaita K, Ahmed R, Zhu C. bioRxiv [Preprint]. 2023 Aug 15:2023.08.13.553152. doi: 10.1101/2023.08.13.553152. PubMed |
| Serine protease 35 regulates the fibroblast matrisome in response to hyperosmotic stress. Sanger CS, Cernakova M, Wietecha MS, Garau Paganella L, Labouesse C, Dudaryeva OY, Roubaty C, Stumpe M, Mazza E, Tibbitt MW, Dengjel J, Werner S. Sci Adv. 2023 Sep;9(35):eadh9219. doi: 10.1126/sciadv.adh9219. Epub 2023 Aug 30. PubMed |
| CRISPR screens decode cancer cell pathways that trigger gammadelta T cell detection. Mamedov MR, Vedova S, Freimer JW, Sahu AD, Ramesh A, Arce MM, Meringa AD, Ota M, Chen PA, Hanspers K, Nguyen VQ, Takeshima KA, Rios AC, Pritchard JK, Kuball J, Sebestyen Z, Adams EJ, Marson A. Nature. 2023 Sep;621(7977):188-195. doi: 10.1038/s41586-023-06482-x. Epub 2023 Aug 30. PubMed |
| SAP30 promotes breast tumor progression by bridging the transcriptional corepressor SIN3 complex and MLL1. Bao L, Kumar A, Zhu M, Peng Y, Xing C, Wang JE, Wang Y, Luo W. J Clin Invest. 2023 Sep 1;133(17):e168362. doi: 10.1172/JCI168362. PubMed |
| The Ca(2+) channel ORAI1 is a regulator of oral cancer growth and nociceptive pain. Son GY, Tu NH, Santi MD, Loya Lopez S, Souza Bomfim GH, Vinu M, Zhou F, Chaloemtoem A, Alhariri R, Idaghdour Y, Khanna R, Ye Y, Lacruz RS. Sci Signal. 2023 Sep 5;16(801):eadf9535. doi: 10.1126/scisignal.adf9535. Epub 2023 Sep 5. PubMed |
| Recapitulation of patient-specific 3D chromatin conformation using machine learning. Xu D, Forbes AN, Cohen S, Palladino A, Karadimitriou T, Khurana E. Cell Rep Methods. 2023 Sep 25;3(9):100578. doi: 10.1016/j.crmeth.2023.100578. Epub 2023 Sep 5. PubMed |
| TGS1/PIMT regulates pro-inflammatory macrophage mediated paracrine insulin resistance: Crosstalk between macrophages and skeletal muscle cells. Challa NL, Sarkar A, Kapettu S, Phanithi PB, Chakrabarti P, Parsa KVL, Misra P. Biochim Biophys Acta Mol Basis Dis. 2024 Jan;1870(1):166878. doi: 10.1016/j.bbadis.2023.166878. Epub 2023 Sep 4. PubMed |
| Structure shows that the BIR2 domain of E3 ligase XIAP binds across the RIPK2 kinase dimer interface. Lethier M, Huard K, Hons M, Favier A, Brutscher B, Boeri Erba E, Abbott DW, Cusack S, Pellegrini E. Life Sci Alliance. 2023 Sep 6;6(11):e202201784. doi: 10.26508/lsa.202201784. Print 2023 Nov. PubMed |
Optogenetic engineering of STING signaling allows remote immunomodulation to enhance cancer immunotherapy.
Dou Y, Chen R, Liu S, Lee YT, Jing J, Liu X, Ke Y, Wang R, Zhou Y, Huang Y.
Nat Commun. 2023 Sep 6;14(1):5461. doi: 10.1038/s41467-023-41164-2.
PubMed
Associated Plasmids |
| Host-derived growth factors drive ERK phosphorylation and MCL1 expression to promote osteosarcoma cell survival during metastatic lung colonization. McAloney CA, Makkawi R, Budhathoki Y, Cannon MV, Franz EM, Gross AC, Cam M, Vetter TA, Duhen R, Davies AE, Roberts RD. Cell Oncol (Dordr). 2024 Feb;47(1):259-282. doi: 10.1007/s13402-023-00867-w. Epub 2023 Sep 7. PubMed |
| Clonal dynamics limits detection of selection in tumour xenograft CRISPR/Cas9 screens. Lee TW, Hunter FW, Tsai P, Print CG, Wilson WR, Jamieson SMF. Cancer Gene Ther. 2023 Dec;30(12):1610-1623. doi: 10.1038/s41417-023-00664-5. Epub 2023 Sep 8. PubMed |
| Targeting Oncogenic Mutant p53 and BCL-2 for Small Cell Lung Cancer Treatment. Neely V, Manchikalapudi A, Nguyen K, Dalton K, Hu B, Koblinski JE, Faber AC, Deb S, Harada H. Int J Mol Sci. 2023 Aug 23;24(17):13082. doi: 10.3390/ijms241713082. PubMed |
| Novel Function of Cancer Stem Cell Marker ALDH1A3 in Glioblastoma: Pro-Angiogenesis through Paracrine PAI-1 and IL-8. Chen Z, Will R, Kim SN, Busch MA, Dunker N, Dammann P, Sure U, Zhu Y. Cancers (Basel). 2023 Sep 4;15(17):4422. doi: 10.3390/cancers15174422. PubMed |
| SOD1 is a synthetic lethal target in PPM1D-mutant leukemia cells. Zhang L, Hsu JI, Braekeleer ED, Chen CW, Patel TD, Martell AG, Guzman AG, Wohlan K, Waldvogel SM, Urya H, Tovy A, Callen E, Murdaugh R, Richard R, Jansen S, Vissers L, de Vries BBA, Nussenzweig A, Huang S, Coarfa C, Anastas JN, Takahashi K, Vassiliou G, Goodell MA. bioRxiv [Preprint]. 2024 Jan 17:2023.08.31.555634. doi: 10.1101/2023.08.31.555634. PubMed |
| Transposable Elements Are Co-opted as Oncogenic Regulatory Elements by Lineage-Specific Transcription Factors in Prostate Cancer. Grillo G, Keshavarzian T, Linder S, Arlidge C, Mout L, Nand A, Teng M, Qamra A, Zhou S, Kron KJ, Murison A, Hawley JR, Fraser M, van der Kwast TH, Raj GV, He HH, Zwart W, Lupien M. Cancer Discov. 2023 Nov 1;13(11):2470-2487. doi: 10.1158/2159-8290.CD-23-0331. PubMed |
| SETD2 Deficiency Confers Sensitivity to Dual Inhibition of DNA Methylation and PARP in Kidney Cancer. Zhou X, Sekino Y, Li HT, Fu G, Yang Z, Zhao S, Gujar H, Zu X, Weisenberger DJ, Gill IS, Tulpule V, D'souza A, Quinn DI, Han B, Liang G. Cancer Res. 2023 Nov 15;83(22):3813-3826. doi: 10.1158/0008-5472.CAN-23-0401. PubMed |
A split and inducible adenine base editor for precise in vivo base editing.
Zeng H, Yuan Q, Peng F, Ma D, Lingineni A, Chee K, Gilberd P, Osikpa EC, Sun Z, Gao X.
Nat Commun. 2023 Sep 11;14(1):5573. doi: 10.1038/s41467-023-41331-5.
PubMed
Associated Plasmids |
| Direct measurement of engineered cancer mutations and their transcriptional phenotypes in single cells. Kim HS, Grimes SM, Chen T, Sathe A, Lau BT, Hwang GH, Bae S, Ji HP. Nat Biotechnol. 2023 Sep 11. doi: 10.1038/s41587-023-01949-8. PubMed |
| Y-27632 acts beyond ROCK inhibition to maintain epidermal stem-like cells in culture. Witkowski TA, Li B, Andersen JG, Kumar B, Mroz EA, Rocco JW. J Cell Sci. 2023 Sep 1;136(17):jcs260990. doi: 10.1242/jcs.260990. Epub 2023 Sep 12. PubMed |
| Experimental and theoretical model for the origin of coiling of cellular protrusions around fibers. Sadhu RK, Hernandez-Padilla C, Eisenbach YE, Penic S, Zhang L, Vishwasrao HD, Behkam B, Konstantopoulos K, Shroff H, Iglic A, Peles E, Nain AS, Gov NS. Nat Commun. 2023 Sep 12;14(1):5612. doi: 10.1038/s41467-023-41273-y. PubMed |
| Increased expression of BRD4 isoforms long (BRD4-L) and short (BRD4-S) promotes chemotherapy resistance in high-grade serous ovarian carcinoma. Drumond-Bock AL, Wang L, Wang L, Cybula M, Rostworowska M, Kinter M, Bieniasz M. Genes Cancer. 2023 Sep 12;14:56-76. doi: 10.18632/genesandcancer.233. eCollection 2023. PubMed |
| The FAM104 proteins VCF1/2 promote the nuclear localization of p97/VCP. Korner M, Meyer SR, Marincola G, Kern MJ, Grimm C, Schuelein-Voelk C, Fischer U, Hofmann K, Buchberger A. Elife. 2023 Sep 15;12:e92409. doi: 10.7554/eLife.92409. PubMed |
| Activation of melanocortin-1 receptor signaling in melanoma cells impairs T cell infiltration to dampen antitumor immunity. Cui Y, Miao Y, Cao L, Guo L, Cui Y, Yan C, Zeng Z, Xu M, Han T. Nat Commun. 2023 Sep 15;14(1):5740. doi: 10.1038/s41467-023-41101-3. PubMed |
| Phenylalanine-tRNA aminoacylation is compromised by ALS/FTD-associated C9orf72 C4G2 repeat RNA. Malnar Crnigoj M, Cercek U, Yin X, Ho MT, Repic Lampret B, Neumann M, Hermann A, Rouleau G, Suter B, Mayr M, Rogelj B. Nat Commun. 2023 Sep 16;14(1):5764. doi: 10.1038/s41467-023-41511-3. PubMed |
| An essential signaling function of cytoplasmic NELFB is independent of RNA polymerase II pausing. Pan H, Cheng X, Rodriguez PFG, Zhang X, Chung I, Jin VX, Li W, Hu Y, Li R. J Biol Chem. 2023 Nov;299(11):105259. doi: 10.1016/j.jbc.2023.105259. Epub 2023 Sep 17. PubMed |
| Reversing T Cell Exhaustion by Converting Membrane PD-1 to Its Soluble form in Jurkat Cells; Applying The CRISPR/Cas9 Exon Skipping Strategy. Yousefi-Najafabadi Z, Mehmandoostli Z, Asgari Y, Kaboli S, Falak R, Kardar GA. Cell J. 2023 Sep 9;25(9):633-644. doi: 10.22074/cellj.2023.1999548.1269. PubMed |
| GLUT3 promotes macrophage signaling and function via RAS-mediated endocytosis in atopic dermatitis and wound healing. Yu DM, Zhao J, Lee EE, Kim D, Mahapatra R, Rose EK, Zhou Z, Hosler C, El Kurdi A, Choe JY, Abel ED, Hoxhaj G, Westover KD, Cho RJ, Cheng JB, Wang RC. J Clin Invest. 2023 Nov 1;133(21):e170706. doi: 10.1172/JCI170706. PubMed |
| Whole-genome screens reveal regulators of differentiation state and context-dependent migration in human neutrophils. Belliveau NM, Footer MJ, Akdogan E, van Loon AP, Collins SR, Theriot JA. Nat Commun. 2023 Sep 18;14(1):5770. doi: 10.1038/s41467-023-41452-x. PubMed |
| Molecular basis for maternal inheritance of human mitochondrial DNA. Lee W, Zamudio-Ochoa A, Buchel G, Podlesniy P, Marti Gutierrez N, Puigros M, Calderon A, Tang HY, Li L, Mikhalchenko A, Koski A, Trullas R, Mitalipov S, Temiakov D. Nat Genet. 2023 Oct;55(10):1632-1639. doi: 10.1038/s41588-023-01505-9. Epub 2023 Sep 18. PubMed |
| Role of the Senescence-Associated Factor Dipeptidyl Peptidase 4 in the Pathogenesis of SARS-CoV-2 Infection. Deinhardt-Emmer S, Deshpande S, Kitazawa K, Herman AB, Bons J, Rose JP, Kumar PA, Anerillas C, Neri F, Ciotlos S, Perez K, Kose-Vogel N, Hader A, Abdelmohsen K, Loffler B, Gorospe M, Desprez PY, Melov S, Furman D, Schilling B, Campisi J. Aging Dis. 2024 May 7;15(3):1398-1415. doi: 10.14336/AD.2023.0812. PubMed |
| Genome-Wide CRISPR Screens Identify Multiple Synthetic Lethal Targets That Enhance KRASG12C Inhibitor Efficacy. Mukhopadhyay S, Huang HY, Lin Z, Ranieri M, Li S, Sahu S, Liu Y, Ban Y, Guidry K, Hu H, Lopez A, Sherman F, Tan YJ, Lee YT, Armstrong AP, Dolgalev I, Sahu P, Zhang T, Lu W, Gray NS, Christensen JG, Tang TT, Velcheti V, Khodadadi-Jamayran A, Wong KK, Neel BG. Cancer Res. 2023 Dec 15;83(24):4095-4111. doi: 10.1158/0008-5472.CAN-23-2729. PubMed |
| C-Myc-induced hypersialylation of small cell lung cancer facilitates pro-tumoral phenotypes of macrophages. Tian L, Li H, Zhao P, Liu Y, Lu Y, Zhong R, Jin Y, Tan T, Cheng Y. iScience. 2023 Aug 29;26(10):107771. doi: 10.1016/j.isci.2023.107771. eCollection 2023 Oct 20. PubMed |
| Differential nanoscale organization of excitatory synapses onto excitatory vs inhibitory neurons. Dharmasri PA, Levy AD, Blanpied TA. bioRxiv [Preprint]. 2023 Sep 7:2023.09.06.556279. doi: 10.1101/2023.09.06.556279. PubMed |
| The NCOR-HDAC3 co-repressive complex modulates the leukemogenic potential of the transcription factor ERG. Kugler E, Madiwale S, Yong D, Thoms JAI, Birger Y, Sykes DB, Schmoellerl J, Drakul A, Priebe V, Yassin M, Aqaqe N, Rein A, Fishman H, Geron I, Chen CW, Raught B, Liu Q, Ogana H, Liedke E, Bourquin JP, Zuber J, Milyavsky M, Pimanda J, Prive GG, Izraeli S. Nat Commun. 2023 Sep 21;14(1):5871. doi: 10.1038/s41467-023-41067-2. PubMed |
| FBXW2 suppresses breast tumorigenesis by targeting AKT-Moesin-SKP2 axis. Barik GK, Sahay O, Mukhopadhyay A, Manne RK, Islam S, Roy A, Nath S, Santra MK. Cell Death Dis. 2023 Sep 22;14(9):623. doi: 10.1038/s41419-023-06127-x. PubMed |
| Protocol to capture transcription factor-mediated 3D chromatin interactions using affinity tag-based BL-HiChIP. Ren R, Hua Y, Wang H. STAR Protoc. 2023 Dec 15;4(4):102589. doi: 10.1016/j.xpro.2023.102589. Epub 2023 Sep 21. PubMed |
| Synaptotagmin 1-triggered lipid signaling facilitates coupling of exo- and endocytosis. Bolz S, Kaempf N, Puchkov D, Krauss M, Russo G, Soykan T, Schmied C, Lehmann M, Muller R, Schultz C, Perrais D, Maritzen T, Haucke V. Neuron. 2023 Dec 6;111(23):3765-3774.e7. doi: 10.1016/j.neuron.2023.08.016. Epub 2023 Sep 21. PubMed |
| SCARB2 drives hepatocellular carcinoma tumor initiating cells via enhanced MYC transcriptional activity. Wang F, Gao Y, Xue S, Zhao L, Jiang H, Zhang T, Li Y, Zhao C, Wu F, Siqin T, Liu Y, Wu J, Yan Y, Yuan J, Jiang JD, Li K. Nat Commun. 2023 Sep 22;14(1):5917. doi: 10.1038/s41467-023-41593-z. PubMed |
| BAP1 promotes osteoclast function by metabolic reprogramming. Rohatgi N, Zou W, Li Y, Cho K, Collins PL, Tycksen E, Pandey G, DeSelm CJ, Patti GJ, Dey A, Teitelbaum SL. Nat Commun. 2023 Sep 22;14(1):5923. doi: 10.1038/s41467-023-41629-4. PubMed |
| Activation of CTNNB1 by deubiquitinase UCHL3-mediated stabilization facilitates bladder cancer progression. Liu T, Fan MQ, Xie XX, Shu QP, Du XH, Qi LZ, Zhang XD, Zhang MH, Shan G, Du RL, Li SZ. J Transl Med. 2023 Sep 22;21(1):656. doi: 10.1186/s12967-023-04311-3. PubMed |
| A novel CAR-T cell product targeting CD74 is an effective therapeutic approach in preclinical mantle cell lymphoma models. Chan WK, Williams J, Sorathia K, Pray B, Abusaleh K, Bian Z, Sharma A, Hout I, Nishat S, Hanel W, Sloan SL, Yasin A, Denlinger N, Zhang X, Muthusamy N, Vasu S, de Lima M, Yang Y, Baiocchi R, Alinari L. Exp Hematol Oncol. 2023 Sep 22;12(1):79. doi: 10.1186/s40164-023-00437-8. PubMed |
| ATLAS: A rationally designed anterograde transsynaptic tracer. Rivera JF, Weng W, Huang H, Rao S, Herring BE, Arnold DB. bioRxiv [Preprint]. 2023 Sep 13:2023.09.12.557425. doi: 10.1101/2023.09.12.557425. PubMed |
| Pyruvate Kinase Activity Regulates Cystine Starvation Induced Ferroptosis through Malic Enzyme 1 in Pancreatic Cancer Cells. Ensink E, Jordan T, Medeiros HCD, Thurston G, Pardal A, Yu L, Lunt SY. bioRxiv [Preprint]. 2023 Sep 17:2023.09.15.557984. doi: 10.1101/2023.09.15.557984. PubMed |
| A Meta-Atlas of the Developing Human Cortex Identifies Modules Driving Cell Subtype Specification. Nano PR, Fazzari E, Azizad D, Nguyen CV, Wang S, Kan RL, Wick B, Haeussler M, Bhaduri A. bioRxiv [Preprint]. 2023 Sep 13:2023.09.12.557406. doi: 10.1101/2023.09.12.557406. PubMed |
| Nectin-3 and shed forms of CSPG4 can serve as epithelial cell receptors for Clostridioides difficile TcdB. Childress KO, Cencer CS, Tyska MJ, Lacy DB. mBio. 2023 Oct 31;14(5):e0185723. doi: 10.1128/mbio.01857-23. Epub 2023 Sep 25. PubMed |
| KCNQ potassium channels modulate Wnt activity in gastro-oesophageal adenocarcinomas. Shorthouse D, Zhuang L, Rahrmann EP, Kosmidou C, Wickham Rahrmann K, Hall M, Greenwood B, Devonshire G, Gilbertson RJ, Fitzgerald RC, Hall BA. Life Sci Alliance. 2023 Sep 25;6(12):e202302124. doi: 10.26508/lsa.202302124. Print 2023 Dec. PubMed |
| Dissecting key regulators of transcriptome kinetics through scalable single-cell RNA profiling of pooled CRISPR screens. Xu Z, Sziraki A, Lee J, Zhou W, Cao J. Nat Biotechnol. 2023 Sep 25. doi: 10.1038/s41587-023-01948-9. PubMed |
| Tetraspanin 1 regulates papillary thyroid tumor growth and metastasis through c-Myc-mediated glycolysis. Han J, Xie C, Liu B, Wang Y, Pang R, Bi W, Sheng R, He G, Kong L, Yu J, Ding Z, Chen L, Jia J, Zhang J, Nie C. Cancer Sci. 2023 Dec;114(12):4535-4547. doi: 10.1111/cas.15970. Epub 2023 Sep 26. PubMed |
| TGS1/PIMT knockdown reduces lipid accumulation in adipocytes, limits body weight gain and promotes insulin sensitivity in mice. Edwin RK, Acharya LP, Maity SK, Chakrabarti P, Tantia O, Joshi MB, Satyamoorthy K, Parsa KVL, Misra P. Biochim Biophys Acta Mol Basis Dis. 2024 Jan;1870(1):166896. doi: 10.1016/j.bbadis.2023.166896. Epub 2023 Sep 24. PubMed |
| Reovirus infection of tumor cells reduces the expression of NKG2D ligands, leading to impaired NK-cell cytotoxicity and functionality. Khaleafi R, Zeleznjak J, Cordela S, Drucker S, Rovis TL, Jonjic S, Bar-On Y. Front Immunol. 2023 Sep 11;14:1231782. doi: 10.3389/fimmu.2023.1231782. eCollection 2023. PubMed |
| Human cytomegalovirus attenuates AKT activity by destabilizing insulin receptor substrate proteins. Domma AJ, Henderson LA, Goodrum FD, Moorman NJ, Kamil JP. J Virol. 2023 Oct 31;97(10):e0056323. doi: 10.1128/jvi.00563-23. Epub 2023 Sep 27. PubMed |
| Omicron variant neutralizing antibodies following BNT162b2 BA.4/5 versus mRNA-1273 BA.1 bivalent vaccination in patients with end-stage kidney disease. Yau K, Kurtesi A, Qi F, Delgado-Brand M, Tursun TR, Hu Q, Dhruve M, Kandel C, Enilama O, Levin A, Jiang Y, Hardy WR, Yuen DA, Perl J, Chan CT, Leis JA, Oliver MJ, Colwill K, Gingras AC, Hladunewich MA. Nat Commun. 2023 Sep 27;14(1):6041. doi: 10.1038/s41467-023-41678-9. PubMed |
| CRISPR/Cas9-Mediated CtBP1 Gene Editing Enhances Chemosensitivity and Inhibits Metastatic Potential in Esophageal Squamous Cell Carcinoma Cells. Akhtar J, Imran M, Wang G. Int J Mol Sci. 2023 Sep 13;24(18):14030. doi: 10.3390/ijms241814030. PubMed |
| A CRISPR Screen of HIV Dependency Factors Reveals That CCNT1 Is Non-Essential in T Cells but Required for HIV-1 Reactivation from Latency. Hafer TL, Felton A, Delgado Y, Srinivasan H, Emerman M. Viruses. 2023 Aug 31;15(9):1863. doi: 10.3390/v15091863. PubMed |
Curved adhesions mediate cell attachment to soft matrix fibres in three dimensions.
Zhang W, Lu CH, Nakamoto ML, Tsai CT, Roy AR, Lee CE, Yang Y, Jahed Z, Li X, Cui B.
Nat Cell Biol. 2023 Sep 28. doi: 10.1038/s41556-023-01238-1.
PubMed
Associated Plasmids |
| Magnetic Resonance Imaging of Iron Metabolism with T2* Mapping Predicts an Enhanced Clinical Response to Pharmacologic Ascorbate in Patients with GBM. Petronek MS, Monga V, Bodeker KL, Kwofie M, Lee CY, Mapuskar KA, Stolwijk JM, Zaher A, Wagner BA, Smith MC, Vollstedt S, Brown H, Chandler ML, Lorack AC, Wulfekuhle JS, Sarkaria JN, Flynn RT, Greenlee JDW, Howard MA, Smith BJ, Jones KA, Buettner GR, Cullen JJ, St-Aubin J, Buatti JM, Magnotta VA, Spitz DR, Allen BG. Clin Cancer Res. 2024 Jan 17;30(2):283-293. doi: 10.1158/1078-0432.CCR-22-3952. PubMed |
| Molecular mechanism by which RRM2-inhibitor (cholagogue osalmid) plus bafilomycin A1 cause autophagic cell death in multiple myeloma. Guo S, Xu Z, Feng Q, Zhang H, Yu D, Li B, Hu K, Gao X, Zhang Q, Yi H, Wu X, Song D, Zhu H, Cai H, Peng Y, Zhu W, Shi J. Arch Biochem Biophys. 2023 Oct 1;747:109771. doi: 10.1016/j.abb.2023.109771. Epub 2023 Sep 28. PubMed |
| Outer membrane protein 25 of Brucella suppresses TLR-mediated expression of proinflammatory cytokines through degradation of TLRs and adaptor proteins. Murugan S, Nandi BR, Mazumdar V, Joshi K, Nandini P, Namani S, Jakka P, Radhakrishnan GK. J Biol Chem. 2023 Nov;299(11):105309. doi: 10.1016/j.jbc.2023.105309. Epub 2023 Sep 29. PubMed |
| Discovering chromatin dysregulation induced by protein-coding perturbations at scale. Frenkel M, Hujoel MLA, Morris Z, Raman S. bioRxiv [Preprint]. 2023 Sep 21:2023.09.20.555752. doi: 10.1101/2023.09.20.555752. PubMed |
| Integrative PTEN Enhancer Discovery Reveals a New Model of Enhancer Organization. Cerda-Smith CG, Hutchinson HM, Liu A, Goel VY, Sept C, Kim H, Casani-Galdon S, Burkman KG, Bassil CF, Hansen AS, Aryee MJ, Johnstone SE, Eyler CE, Wood KC. bioRxiv [Preprint]. 2023 Sep 21:2023.09.20.558459. doi: 10.1101/2023.09.20.558459. PubMed |
| NSD1 supports cell growth and regulates autophagy in HPV-negative head and neck squamous cell carcinoma. Topchu I, Bychkov I, Gursel D, Makhov P, Boumber Y. bioRxiv [Preprint]. 2023 Sep 22:2023.09.19.558537. doi: 10.1101/2023.09.19.558537. PubMed |
| MTGR1 is required to maintain small intestinal stem cell populations. Williams C, Brown R, Zhao Y, Wang J, Chen Z, Blunt K, Pilat J, Parang B, Choksi Y, Lau K, Hiebert S, Short S, Jacobse J, Xu Y, Yang Y, Goettel J. Res Sq [Preprint]. 2023 Sep 21:rs.3.rs-3315071. doi: 10.21203/rs.3.rs-3315071/v1. PubMed |
| Differential Modulation of Polycomb-Associated Histone Marks by cBAF, pBAF, and gBAF Complexes. Bergwell M, Park J, Kirkland JG. bioRxiv [Preprint]. 2024 Jan 24:2023.09.23.557848. doi: 10.1101/2023.09.23.557848. PubMed |
PAM-flexible genome editing with an engineered chimeric Cas9.
Zhao L, Koseki SRT, Silverstein RA, Amrani N, Peng C, Kramme C, Savic N, Pacesa M, Rodriguez TC, Stan T, Tysinger E, Hong L, Yudistyra V, Ponnapati MR, Jacobson JM, Church GM, Jakimo N, Truant R, Jinek M, Kleinstiver BP, Sontheimer EJ, Chatterjee P.
Nat Commun. 2023 Oct 4;14(1):6175. doi: 10.1038/s41467-023-41829-y.
PubMed
Associated Plasmids |
| The Physical Biology of Nucleolus Disassembly. Pham AT, Mani M, Wang XA, Vafabakhsh R. bioRxiv [Preprint]. 2023 Sep 29:2023.09.27.559731. doi: 10.1101/2023.09.27.559731. PubMed |
| Target gene regulatory network of miR-497 in angiosarcoma. Benton A, Terwilliger E, Moriarty NM, Liu B, Murphy A, Maluvac H, Shu M, Gartenhaus LE, Janson ND, Pfeffer CM, Utturkar SM, Parkinson EI, Lanman NA, Hanna JA. bioRxiv [Preprint]. 2023 Sep 25:2023.09.24.559218. doi: 10.1101/2023.09.24.559218. PubMed |
| In situ visualization of m6A sites in cellular mRNAs. Sheehan CJ, Marayati BF, Bhatia J, Meyer KD. Nucleic Acids Res. 2023 Nov 10;51(20):e101. doi: 10.1093/nar/gkad787. PubMed |
Comprehensive split TEV based protein-protein interaction screening reveals TAOK2 as a key modulator of Hippo signalling to limit growth.
Ma X, Mandausch FJ, Wu Y, Sahoo VK, Ma W, Leoni G, Hostiuc M, Wintgens JP, Qiu J, Kannaiyan N, Rossner MJ, Wehr MC.
Cell Signal. 2024 Jan;113:110917. doi: 10.1016/j.cellsig.2023.110917. Epub 2023 Oct 7.
PubMed
Associated Plasmids |
| FAM210A is essential for cold-induced mitochondrial remodeling in brown adipocytes. Qiu J, Yue F, Zhu P, Chen J, Xu F, Zhang L, Kim KH, Snyder MM, Luo N, Xu HW, Huang F, Tao WA, Kuang S. Nat Commun. 2023 Oct 10;14(1):6344. doi: 10.1038/s41467-023-41988-y. PubMed |
| The RNA methyltransferase METTL16 enhances cholangiocarcinoma growth through PRDM15-mediated FGFR4 expression. Liu N, Zhang J, Chen W, Ma W, Wu T. J Exp Clin Cancer Res. 2023 Oct 11;42(1):263. doi: 10.1186/s13046-023-02844-5. PubMed |
Global analysis of suppressor mutations that rescue human genetic defects.
Unlu B, Pons C, Ho UL, Batte A, Aloy P, van Leeuwen J.
Genome Med. 2023 Oct 12;15(1):78. doi: 10.1186/s13073-023-01232-0.
PubMed
Associated Plasmids |
| Glycosylated Delta-receptor-binding domain mucosal vaccine elicits broadly neutralizing antibodies with protection against SARS-CoV-2 challenge. Guan X, Verma AK, Wang G, Shi J, Perlman S, Du L. iScience. 2023 Sep 27;26(10):108033. doi: 10.1016/j.isci.2023.108033. eCollection 2023 Oct 20. PubMed |
| Connective tissue mast cells store and release noradrenaline. Otani Y, Yoshikawa S, Nagao K, Tanaka T, Toyooka S, Fujimura A. J Physiol Sci. 2023 Oct 12;73(1):24. doi: 10.1186/s12576-023-00883-3. PubMed |
| Overexpression of FRA1 (FOSL1) Leads to Global Transcriptional Perturbations, Reduced Cellular Adhesion and Altered Cell Cycle Progression. Al-Khayyat W, Pirkkanen J, Dougherty J, Laframboise T, Dickinson N, Khaper N, Lees SJ, Mendonca MS, Boreham DR, Tai TC, Thome C, Tharmalingam S. Cells. 2023 Sep 24;12(19):2344. doi: 10.3390/cells12192344. PubMed |
| An Efficient and Cost-Effective Approach to Generate Functional Human Inducible Pluripotent Stem Cell-Derived Astrocytes. Gonzalez H, Narasipura SD, Shull T, Shetty A, Teppen TL, Naqib A, Al-Harthi L. Cells. 2023 Sep 26;12(19):2357. doi: 10.3390/cells12192357. PubMed |
| In Cerebellar Atrophy of 12-Month-Old ATM-Null Mice, Transcriptome Upregulations Concern Most Neurotransmission and Neuropeptide Pathways, While Downregulations Affect Prominently Itpr1, Usp2 and Non-Coding RNA. Reichlmeir M, Canet-Pons J, Koepf G, Nurieva W, Duecker RP, Doering C, Abell K, Key J, Stokes MP, Zielen S, Schubert R, Ivics Z, Auburger G. Cells. 2023 Oct 3;12(19):2399. doi: 10.3390/cells12192399. PubMed |
| PTBP2 attenuation facilitates fibroblast to neuron conversion by promoting alternative splicing of neuronal genes. Zhu B, Fisher E, Li L, Zhong P, Yan Z, Feng J. Stem Cell Reports. 2023 Nov 14;18(11):2268-2282. doi: 10.1016/j.stemcr.2023.09.012. Epub 2023 Oct 12. PubMed |
| DNA damage induces nuclear envelope rupture through ATR-mediated phosphorylation of lamin A/C. Kovacs MT, Vallette M, Wiertsema P, Dingli F, Loew D, Nader GPF, Piel M, Ceccaldi R. Mol Cell. 2023 Oct 19;83(20):3659-3668.e10. doi: 10.1016/j.molcel.2023.09.023. Epub 2023 Oct 12. PubMed |
| DNA damage induced by CDK4 and CDK6 blockade triggers anti-tumor immune responses through cGAS-STING pathway. Fan H, Liu W, Zeng Y, Zhou Y, Gao M, Yang L, Liu H, Shi Y, Li L, Ma J, Ruan J, Cao R, Jin X, Chen J, Cheng G, Yang H. Commun Biol. 2023 Oct 13;6(1):1041. doi: 10.1038/s42003-023-05412-x. PubMed |
| MANF stimulates autophagy and restores mitochondrial homeostasis to treat autosomal dominant tubulointerstitial kidney disease in mice. Kim Y, Li C, Gu C, Fang Y, Tycksen E, Puri A, Pietka TA, Sivapackiam J, Kidd K, Park SJ, Johnson BG, Kmoch S, Duffield JS, Bleyer AJ, Jackrel ME, Urano F, Sharma V, Lindahl M, Chen YM. Nat Commun. 2023 Oct 14;14(1):6493. doi: 10.1038/s41467-023-42154-0. PubMed |
| miR-199a and miR-199b facilitate diffuse gastric cancer progression by targeting Frizzled-6. Hong SA, Lee S, Park J, Hong M, Yoon JS, Lee H, Lee JH, Kim S, Won HS, Kang K, Ko YH, Ahn YH. Sci Rep. 2023 Oct 14;13(1):17480. doi: 10.1038/s41598-023-44716-0. PubMed |
| The Influence of Human IgG Subclass and Allotype on Complement Activation. Damelang T, de Taeye SW, Rentenaar R, Roya-Kouchaki K, de Boer E, Derksen NIL, van Kessel K, Lissenberg-Thunnissen S, Rooijakkers SHM, Jongerius I, Mebius MM, Schuurman J, Labrijn AF, Vidarsson G, Rispens T. J Immunol. 2023 Dec 1;211(11):1725-1735. doi: 10.4049/jimmunol.2300307. PubMed |
| Functional classification of DDOST variants of uncertain clinical significance in congenital disorders of glycosylation. Kas SM, Mundra PA, Smith DL, Marais R. Sci Rep. 2023 Oct 17;13(1):17648. doi: 10.1038/s41598-023-42178-y. PubMed |
| Spontaneous metastasis xenograft models link CD44 isoform 4 to angiogenesis, hypoxia, EMT and mitochondria-related pathways in colorectal cancer. Everest-Dass A, Nersisyan S, Maar H, Novosad V, Schroder-Schwarz J, Freytag V, Stuke JL, Beine MC, Schiecke A, Haider MT, Kriegs M, Elakad O, Bohnenberger H, Conradi LC, Raygorodskaya M, Krause L, von Itzstein M, Tonevitsky A, Schumacher U, Maltseva D, Wicklein D, Lange T. Mol Oncol. 2024 Jan;18(1):62-90. doi: 10.1002/1878-0261.13535. Epub 2023 Nov 3. PubMed |
| Hypoxia stabilizes SETDB1 to maintain genome stability. Park S, Cho JH, Kim JH, Park M, Park S, Kim SY, Kim SK, Kim K, Park SG, Park BC, Moon JH, Lee G, Kim S, Kim JA, Kim JH. Nucleic Acids Res. 2023 Nov 10;51(20):11178-11196. doi: 10.1093/nar/gkad796. PubMed |
| PCSK9 activation promotes early atherosclerosis in a vascular microphysiological system. Lee JH, Shores KL, Breithaupt JJ, Lee CS, Fodera DM, Kwon JB, Ettyreddy AR, Myers KM, Evison BJ, Suchowerska AK, Gersbach CA, Leong KW, Truskey GA. APL Bioeng. 2023 Oct 16;7(4):046103. doi: 10.1063/5.0167440. eCollection 2023 Dec. PubMed |
| A CRISPR activation screen identifies MUC-21 as critical for resistance to NK and T cell-mediated cytotoxicity. Lee DH, Ahn H, Sim HI, Choi E, Choi S, Jo Y, Yun B, Song HK, Oh SJ, Denda-Nagai K, Park CS, Irimura T, Park Y, Jin HS. J Exp Clin Cancer Res. 2023 Oct 20;42(1):272. doi: 10.1186/s13046-023-02840-9. PubMed |
| m(6)A demethylase FTO stabilizes LINK-A to exert oncogenic roles via MCM3-mediated cell-cycle progression and HIF-1alpha activation. Nan Y, Liu S, Luo Q, Wu X, Zhao P, Chang W, Zhang R, Li Y, Liu Z. Cell Rep. 2023 Oct 31;42(10):113273. doi: 10.1016/j.celrep.2023.113273. Epub 2023 Oct 19. PubMed |
| Role of ciliopathy protein TMEM107 in eye development: insights from a mouse model and retinal organoid. Dubaic M, Peskova L, Hampl M, Weissova K, Celiker C, Shylo NA, Hruba E, Kavkova M, Zikmund T, Weatherbee SD, Kaiser J, Barta T, Buchtova M. Life Sci Alliance. 2023 Oct 20;6(12):e202302073. doi: 10.26508/lsa.202302073. Print 2023 Dec. PubMed |
| A conformation-locking inhibitor of SLC15A4 with TASL proteostatic anti-inflammatory activity. Boeszoermenyi A, Bernaleau L, Chen X, Kartnig F, Xie M, Zhang H, Zhang S, Delacretaz M, Koren A, Hopp AK, Dvorak V, Kubicek S, Aletaha D, Yang M, Rebsamen M, Heinz LX, Superti-Furga G. Nat Commun. 2023 Oct 20;14(1):6626. doi: 10.1038/s41467-023-42070-3. PubMed |
| A PARP14/TARG1-Regulated RACK1 MARylation Cycle Drives Stress Granule Dynamics in Ovarian Cancer Cells. Challa S, Nandu T, Kim HB, Gong A, Renshaw CW, Li WC, Tan X, Camacho CV, Chen J, Kraus WL. bioRxiv [Preprint]. 2023 Oct 14:2023.10.13.562273. doi: 10.1101/2023.10.13.562273. PubMed |
| Development of Stable CHO-K1 Cell Lines Overexpressing Full-Length Human CD20 Antigen. Mohammadkhani N, Rahimpour A, Hoseinpoor R, Rajabibazl M. Iran Biomed J. 2023 Sep 1;27(5):269-79. doi: 10.61186/ibj.27.5.269. Epub 2023 Jul 8. PubMed |
| Tumor-repopulating cell-derived microparticles elicit cascade amplification of chemotherapy-induced antitumor immunity to boost anti-PD-1 therapy. Bie N, Yong T, Wei Z, Liang Q, Zhang X, Li S, Li X, Li J, Gan L, Yang X. Signal Transduct Target Ther. 2023 Oct 25;8(1):408. doi: 10.1038/s41392-023-01658-3. PubMed |
| ZSCAN4 interacts with PARP1 to promote DNA repair in mouse embryonic stem cells. Tsai LK, Peng M, Chang CC, Wen L, Liu L, Liang X, Chen YE, Xu J, Sung LY. Cell Biosci. 2023 Oct 24;13(1):193. doi: 10.1186/s13578-023-01140-1. PubMed |
| A SNAI2/CTCF Interaction is Required for NOTCH1 Expression in Rhabdomyosarcoma. Sreenivas P, Wang L, Wang M, Challa A, Modi P, Hensch NR, Gryder B, Chou HC, Zhao XR, Sunkel B, Moreno-Campos R, Khan J, Stanton BZ, Ignatius MS. Mol Cell Biol. 2023;43(11):547-565. doi: 10.1080/10985549.2023.2256640. Epub 2023 Nov 17. PubMed |
| The role of branched-chain aminotransferase 1 in driving glioblastoma cell proliferation and invasion varies with tumor subtype. Fala M, Ros S, Sawle A, Rao JU, Tsyben A, Tronci L, Frezza C, Mair R, Brindle KM. Neurooncol Adv. 2023 Sep 16;5(1):vdad120. doi: 10.1093/noajnl/vdad120. eCollection 2023 Jan-Dec. PubMed |
| capital ES, Cyrillicytotoxic effect of CAR-T cells against modified MCF-7 breast cancer cell line. Valiullina AK, Zmievskaya EA, Ganeeva IA, Zhuravleva MN, Garanina EE, Rizvanov AA, Petukhov AV, Bulatov ER. Mol Biol Res Commun. 2023;12(4):139-148. doi: 10.22099/mbrc.2023.47125.1820. PubMed |
| Mesothelial Cells Exhibit Characteristics of Perivascular Cells in an In Vitro Angiogenesis Assay. Koukorava C, Ward K, Ahmed K, Almaghrabi S, Dauleh S, Pereira SM, Taylor A, Haddrick M, Cross MJ, Wilm B. Cells. 2023 Oct 11;12(20):2436. doi: 10.3390/cells12202436. PubMed |
| PLK1 promotes the mitotic surveillance pathway by controlling cytosolic 53BP1 availability. Burigotto M, Vigorito V, Gliech C, Mattivi A, Ghetti S, Bisio A, Lolli G, Holland AJ, Fava LL. EMBO Rep. 2023 Dec 6;24(12):e57234. doi: 10.15252/embr.202357234. Epub 2023 Oct 27. PubMed |
| Design and deep learning of synthetic B-cell-specific promoters. Fu ZH, He SZ, Wu Y, Zhao GR. Nucleic Acids Res. 2023 Nov 27;51(21):11967-11979. doi: 10.1093/nar/gkad930. PubMed |
| Inactivation of Tumor Suppressor CYLD Inhibits Fibroblast Reprogramming to Pluripotency. Bekas N, Samiotaki M, Papathanasiou M, Mokos P, Pseftogas A, Xanthopoulos K, Thanos D, Mosialos G, Dafou D. Cancers (Basel). 2023 Oct 15;15(20):4997. doi: 10.3390/cancers15204997. PubMed |
| Human Non-Small Cell Lung Cancer-Chicken Embryo Chorioallantoic Membrane Tumor Models for Experimental Cancer Treatments. Li J, Brachtlova T, van der Meulen-Muileman IH, Kleerebezem S, Liu C, Li P, van Beusechem VW. Int J Mol Sci. 2023 Oct 21;24(20):15425. doi: 10.3390/ijms242015425. PubMed |
| Amphipathic Cell-Penetrating Peptide-Aided Delivery of Cas9 RNP for In Vitro Gene Editing and Correction. Oktem M, Mastrobattista E, de Jong OG. Pharmaceutics. 2023 Oct 20;15(10):2500. doi: 10.3390/pharmaceutics15102500. PubMed |
| Transglutaminase 2 Prevents Premature Senescence and Promotes Osteoblastic Differentiation of Mesenchymal Stem Cells through NRF2 Activation. Lee SJ, Shin JW, Kwon MA, Lee KB, Kim HJ, Lee JH, Kang HS, Jun JK, Cho SY, Kim IG. Stem Cells Int. 2023 Oct 20;2023:8815888. doi: 10.1155/2023/8815888. eCollection 2023. PubMed |
| Landscape of enhancer disruption and functional screen in melanoma cells. Wang Z, Luo M, Liang Q, Zhao K, Hu Y, Wang W, Feng X, Hu B, Teng J, You T, Li R, Bao Z, Pan W, Yang T, Zhang C, Li T, Dong X, Yi X, Liu B, Zhao L, Li M, Chen K, Song W, Yang J, Li MJ. Genome Biol. 2023 Oct 30;24(1):248. doi: 10.1186/s13059-023-03087-5. PubMed |
| ONECUT2 Activates Diverse Resistance Drivers of Androgen Receptor-Independent Heterogeneity in Prostate Cancer. Qian C, Yang Q, Rotinen M, Huang R, Kim H, Gallent B, Yan Y, Cadaneanu RM, Zhang B, Kaochar S, Freedland SJ, Posadas EM, Ellis L, Vizio DD, Morrissey C, Nelson PS, Brady L, Murali R, Campbell MJ, Yang W, Knudsen BS, Mostaghel EA, Ye H, Garraway IP, You S, Freeman MR. bioRxiv [Preprint]. 2023 Oct 12:2023.09.28.560025. doi: 10.1101/2023.09.28.560025. PubMed |
| An intronic enhancer of Cebpa regulates adipocyte differentiation and adipose tissue development via long-range loop formation. Li X, Zeng S, Chen L, Zhang Y, Li X, Zhang B, Su D, Du Q, Zhang J, Wang H, Zhong Z, Zhang J, Li P, Jiang A, Long K, Li M, Ge L. Cell Prolif. 2024 Mar;57(3):e13552. doi: 10.1111/cpr.13552. Epub 2023 Oct 31. PubMed |
| The Expression of LDL-R in CD8(+) T Cells Serves as an Early Assessment Parameter for the Production of TCR-T Cells. Wang YI, Hao YN, Shen MY, Han XJ, Wang YM, Chen SY, Wang JF, Wang W, Li TT, Jin AS. In Vivo. 2023 Nov-Dec;37(6):2480-2489. doi: 10.21873/invivo.13355. PubMed |
| In vitro formation and extended culture of highly metabolically active and contractile tissues. Bagdasarian IA, Tonmoy TI, Park BH, Morgan JT. PLoS One. 2023 Nov 1;18(11):e0293609. doi: 10.1371/journal.pone.0293609. eCollection 2023. PubMed |
Targeting the non-coding genome and temozolomide signature enables CRISPR-mediated glioma oncolysis.
Tan IL, Perez AR, Lew RJ, Sun X, Baldwin A, Zhu YK, Shah MM, Berger MS, Doudna JA, Fellmann C.
Cell Rep. 2023 Nov 28;42(11):113339. doi: 10.1016/j.celrep.2023.113339. Epub 2023 Nov 2.
PubMed
Associated Plasmids |
| Glycoengineered keratinocyte library reveals essential functions of specific glycans for all stages of HSV-1 infection. Bagdonaite I, Marinova IN, Rudjord-Levann AM, Pallesen EMH, King-Smith SL, Karlsson R, Romer TB, Chen YH, Miller RL, Olofsson S, Norden R, Bergstrom T, Dabelsteen S, Wandall HH. Nat Commun. 2023 Nov 2;14(1):7000. doi: 10.1038/s41467-023-42669-6. PubMed |
| ORAOV1, CCND1, and MIR548K Are the Driver Oncogenes of the 11q13 Amplicon in Squamous Cell Carcinoma. Mahieu CI, Mancini AG, Vikram EP, Planells-Palop V, Joseph NM, Tward AD. Mol Cancer Res. 2024 Feb 1;22(2):152-168. doi: 10.1158/1541-7786.MCR-23-0746. PubMed |
| A Metabolic Gene Survey Pinpoints Fucosylation as a Key Pathway Underlying the Suppressive Function of Regulatory T Cells in Cancer. Pinioti S, Sharma H, Flerin NC, Yu Q, Tzoumpa A, Trusso Cafarello S, De Bousser E, Callewaert N, Oldenhove G, Schlenner S, Thienpont B, Garg AD, Di Matteo M, Mazzone M. Cancer Immunol Res. 2023 Dec 1;11(12):1611-1629. doi: 10.1158/2326-6066.CIR-22-0606. PubMed |
| EZH2 inhibition stimulates repetitive element expression and viral mimicry in resting splenic B cells. Kim SJ, Kiser PK, Asfaha S, DeKoter RP, Dick FA. EMBO J. 2023 Dec 11;42(24):e114462. doi: 10.15252/embj.2023114462. Epub 2023 Nov 7. PubMed |
TEAD Inhibition Overcomes YAP1/TAZ-driven Primary and Acquired Resistance to KRASG12C Inhibitors.
Edwards AC, Stalnecker CA, Jean Morales A, Taylor KE, Klomp JE, Klomp JA, Waters AM, Sudhakar N, Hallin J, Tang TT, Olson P, Post L, Christensen JG, Cox AD, Der CJ.
Cancer Res. 2023 Nov 7. doi: 10.1158/0008-5472.CAN-23-2994.
PubMed
Associated Plasmids |
| Combining organotypic tissue culture with light-sheet microscopy (OTCxLSFM) to study glioma invasion. Haydo A, Wehle A, Herold-Mende C, Kogel D, Pampaloni F, Linder B. EMBO Rep. 2023 Dec 6;24(12):e56964. doi: 10.15252/embr.202356964. Epub 2023 Nov 8. PubMed |
| Head and neck cancer stem cell maintenance relies on mTOR signaling, specifically involving the mechanistic target of rapamycin complexes 1 and 2 (mTORC1 and mTORC2). Almeida LO, Silva LC, Emerick C, Amorim Dos Santos J, Castilho RM, Squarize CH. Arch Oral Biol. 2024 Jan;157:105840. doi: 10.1016/j.archoralbio.2023.105840. Epub 2023 Nov 1. PubMed |
| FAM222A, Part of the BET-Regulated Basal Endothelial Transcriptome, Is a Novel Determinant of Endothelial Biology and Angiogenesis-Brief Report. Tzani A, Haemmig S, Cheng HS, Perez-Cremades D, Heuschkel MA, Jamaiyar A, Singh SA, Aikawa M, Yu PB, Wang T, Sun Y, Feinberg MW, Plutzky J. Arterioscler Thromb Vasc Biol. 2024 Jan;44(1):143-155. doi: 10.1161/ATVBAHA.123.319909. Epub 2023 Nov 9. PubMed |
| Checkpoint kinase 2 controls insulin secretion and glucose homeostasis. Chong ACN, Vandana JJ, Jeng G, Li G, Meng Z, Duan X, Zhang T, Qiu Y, Duran-Struuck R, Coker K, Wang W, Li Y, Min Z, Zuo X, de Silva N, Chen Z, Naji A, Hao M, Liu C, Chen S. Nat Chem Biol. 2023 Nov 9. doi: 10.1038/s41589-023-01466-4. PubMed |
| Anticancer activity of Bacopa monnieri through apoptosis induction and mitophagy-dependent NLRP3 inflammasome inhibition in oral squamous cell carcinoma. Mishra SR, Behera BP, Singh VK, Mahapatra KK, Mundkinajeddu D, Bhat D, Minz AM, Sethi G, Efferth T, Das S, Bhutia SK. Phytomedicine. 2024 Jan;123:155157. doi: 10.1016/j.phymed.2023.155157. Epub 2023 Oct 21. PubMed |
| A combinatorial therapeutic approach to enhance FLT3-ITD AML treatment. Long J, Chen X, Shen Y, Lei Y, Mu L, Wang Z, Xiang R, Gao W, Wang L, Wang L, Jiang J, Zhang W, Lu H, Dong Y, Ding Y, Zhu H, Hong D, Sun YE, Hu J, Liang A. Cell Rep Med. 2023 Nov 21;4(11):101286. doi: 10.1016/j.xcrm.2023.101286. Epub 2023 Nov 10. PubMed |
| RACK1 promotes Shigella flexneri actin-mediated invasion, motility, and cell-to-cell spreading. Valenzuela-Valderas KN, Farrashzadeh E, Chang YY, Shi Y, Raudonis R, Leung BM, Rohde JR, Enninga J, Cheng Z. iScience. 2023 Oct 14;26(11):108216. doi: 10.1016/j.isci.2023.108216. eCollection 2023 Nov 17. PubMed |
| Molecular Determinants of Calcitriol Signaling and Sensitivity in Glioma Stem-like Cells. Rehbein S, Possmayer AL, Bozkurt S, Lotsch C, Gerstmeier J, Burger M, Momma S, Maletzki C, Classen CF, Freiman TM, Dubinski D, Lamszus K, Stringer BW, Herold-Mende C, Munch C, Kogel D, Linder B. Cancers (Basel). 2023 Oct 31;15(21):5249. doi: 10.3390/cancers15215249. PubMed |
| Integrative analysis reveals therapeutic potential of pyrvinium pamoate in Merkel cell carcinoma. Yang J, Lim JT, Victor P, Chen C, Khwaja H, Schnellmann RG, Roe DJ, Gokhale PC, DeCaprio JA, Padi M. bioRxiv [Preprint]. 2023 Nov 4:2023.11.01.565218. doi: 10.1101/2023.11.01.565218. PubMed |
| Decreased fucosylation impacts epithelial integrity and increases risk for COPD. Swaby C, Yeung-Luk B, Thapa S, Nishida K, Wally A, Ghosh B, Niederkofler A, Luk S, Girgis M, Keller A, Cortez C, Ramaswamy S, Wilmsen K, Bouche L, Dell A, Drummond MB, Putcha N, Haslam SM, Mathias R, Hansel NN, Sheng J, Sidhaye V. bioRxiv [Preprint]. 2023 Nov 2:2023.10.31.564805. doi: 10.1101/2023.10.31.564805. PubMed |
| Legionella pneumophila exploits the endo-lysosomal network for phagosome biogenesis by co-opting SUMOylated Rab7. Li C, Fu J, Shao S, Luo ZQ. bioRxiv [Preprint]. 2023 Oct 31:2023.10.31.564884. doi: 10.1101/2023.10.31.564884. PubMed |
Modular vector assembly enables rapid assessment of emerging CRISPR technologies.
McGee AV, Liu YV, Griffith AL, Szegletes ZM, Wen B, Kraus C, Miller NW, Steger RJ, Escude Velasco B, Bosch JA, Zirin JD, Viswanatha R, Sontheimer EJ, Goodale A, Greene MA, Green TM, Doench JG.
Cell Genom. 2024 Mar 13;4(3):100519. doi: 10.1016/j.xgen.2024.100519.
PubMed
Associated Plasmids |
| A partial human LCK defect causes a T cell immunodeficiency with intestinal inflammation. Lui VG, Hoenig M, Cabrera-Martinez B, Baxter RM, Garcia-Perez JE, Bailey O, Acharya A, Lundquist K, Capera J, Matusewicz P, Hartl FA, D'Abramo M, Alba J, Jacobsen EM, Niewolik D, Lorenz M, Pannicke U, Schulz AS, Debatin KM, Schamel WW, Minguet S, Gumbart JC, Dustin ML, Cambier JC, Schwarz K, Hsieh EWY. J Exp Med. 2024 Jan 1;221(1):e20230927. doi: 10.1084/jem.20230927. Epub 2023 Nov 14. PubMed |
| R-Loop Accumulation in Spliceosome Mutant Leukemias Confers Sensitivity to PARP1 Inhibition by Triggering Transcription-Replication Conflicts. Liu ZS, Sinha S, Bannister M, Song A, Arriaga-Gomez E, McKeeken AJ, Bonner EA, Hanson BK, Sarchi M, Takashima K, Zong D, Corral VM, Nguyen E, Yoo J, Chiraphapphaiboon W, Leibson C, McMahon MC, Rai S, Swisher EM, Sachs Z, Chatla S, Stirewalt DL, Deeg HJ, Skorski T, Papapetrou EP, Walter MJ, Graubert TA, Doulatov S, Lee SC, Nguyen HD. Cancer Res. 2024 Feb 15;84(4):577-597. doi: 10.1158/0008-5472.CAN-23-3239. PubMed |
| Super-enhancer driven SOX2 promotes tumor formation by chromatin re-organization in nasopharyngeal carcinoma. Liu SX, Wang C, Lin RB, Ding WY, Roy G, Wang HB, Yang T, Liu Q, Luo YL, Jin SL, Zeng MS, Zhao B, Zhong Q. EBioMedicine. 2023 Dec;98:104870. doi: 10.1016/j.ebiom.2023.104870. Epub 2023 Nov 14. PubMed |
| PAX3-FOXO1 dictates myogenic reprogramming and rhabdomyosarcoma identity in endothelial progenitors. Searcy MB, Larsen RK 4th, Stevens BT, Zhang Y, Jin H, Drummond CJ, Langdon CG, Gadek KE, Vuong K, Reed KB, Garcia MR, Xu B, Kimbrough DW, Adkins GE, Djekidel N, Porter SN, Schreiner PA, Pruett-Miller SM, Abraham BJ, Rehg JE, Hatley ME. Nat Commun. 2023 Nov 15;14(1):7291. doi: 10.1038/s41467-023-43044-1. PubMed |
| The CD2v protein of African swine fever virus inhibits macrophage migration and inflammatory cytokines expression by downregulating EGR1 expression through dampening ERK1/2 activity. Zhang M, Lv L, Luo H, Cai H, Yu L, Jiang Y, Gao F, Tong W, Li L, Li G, Zhou Y, Tong G, Liu C. Vet Res. 2023 Nov 15;54(1):106. doi: 10.1186/s13567-023-01239-w. PubMed |
| GXMR-CAR containing distinct GXM-specific single-chain variable fragment (scFv) mediated the cell activation against Cryptococcus spp. And had difference in the strength of tonic signaling. Machado MP, Dos Santos MH, Guimaraes JG, de Campos GY, Oliveira Brito PKM, Ferreira CMG, Rezende CP, Frota NF, Soares SG, Kumaresan PR, Lourenzoni MR, da Silva TA. Bioengineered. 2023 Dec;14(1):2281059. doi: 10.1080/21655979.2023.2281059. Epub 2023 Nov 18. PubMed |
| Cell-type-specific need of Ddx3 and PACT for interferon induction by RNA viruses. Sharma N, Kessler P, Sen GC. J Virol. 2023 Dec 21;97(12):e0130423. doi: 10.1128/jvi.01304-23. Epub 2023 Nov 20. PubMed |
| Direct and biologically significant interactions of human herpesvirus 8 interferon regulatory factor 1 with STAT3 and Janus kinase TYK2. Yang Z, Xiang Q, Nicholas J. PLoS Pathog. 2023 Nov 20;19(11):e1011806. doi: 10.1371/journal.ppat.1011806. eCollection 2023 Nov. PubMed |
| Wireless, battery-free, multifunctional integrated bioelectronics for respiratory pathogens monitoring and severity evaluation. Li H, Gong H, Wong TH, Zhou J, Wang Y, Lin L, Dou Y, Jia H, Huang X, Gao Z, Shi R, Huang Y, Chen Z, Park W, Li JY, Chu H, Jia S, Wu H, Wu M, Liu Y, Li D, Li J, Xu G, Chang T, Zhang B, Gao Y, Su J, Bai H, Hu J, Yiu CK, Xu C, Hu W, Huang J, Chang L, Yu X. Nat Commun. 2023 Nov 20;14(1):7539. doi: 10.1038/s41467-023-43189-z. PubMed |
| PRMT1 Inhibition Activates the Interferon Pathway to Potentiate Antitumor Immunity and Enhance Checkpoint Blockade Efficacy in Melanoma. Tao H, Jin C, Zhou L, Deng Z, Li X, Dang W, Fan S, Li B, Ye F, Lu J, Kong X, Liu C, Luo C, Zhang Y. Cancer Res. 2024 Feb 1;84(3):419-433. doi: 10.1158/0008-5472.CAN-23-1082. PubMed |
| ELOA3: A primate-specific RNA polymerase II elongation factor encoded by a tandem repeat gene cluster. Morgan MAJ, Mohammad Parast S, Iwanaszko M, Aoi Y, Yoo D, Dumar ZJ, Howard BC, Helmin KA, Liu Q, Thakur WR, Zeidner JM, Singer BD, Eichler EE, Shilatifard A. Sci Adv. 2023 Nov 24;9(47):eadj1261. doi: 10.1126/sciadv.adj1261. Epub 2023 Nov 22. PubMed |
| Retrovirus-like gag protein Arc/Arg3.1 is involved in extracellular-vesicle-mediated mRNA transfer between glioma cells. Al Othman A, Bagrov D, Rozenberg JM, Glazova O, Skryabin G, Tchevkina E, Mezentsev A, Durymanov M. Biochim Biophys Acta Gen Subj. 2024 Jan;1868(1):130522. doi: 10.1016/j.bbagen.2023.130522. Epub 2023 Nov 22. PubMed |
| Genomic analysis reveals HDAC1 regulates clinically relevant transcriptional programs in Pancreatic cancer. Wright CA, Gordon ER, Cooper SJ. BMC Cancer. 2023 Nov 23;23(1):1137. doi: 10.1186/s12885-023-11645-0. PubMed |
| Unraveling the Mechanisms of Sensitivity to Anti-FGF Therapies in Imatinib-Resistant Gastrointestinal Stromal Tumors (GIST) Lacking Secondary KIT Mutations. Boichuk S, Dunaev P, Skripova V, Galembikova A, Bikinieva F, Shagimardanova E, Gazizova G, Deviatiiarov R, Valeeva E, Mikheeva E, Vasilyeva M, Kopnin P, Strelnikov V, Kiyamova R. Cancers (Basel). 2023 Nov 9;15(22):5354. doi: 10.3390/cancers15225354. PubMed |
| The m(7)G Reader NCBP2 Promotes Pancreatic Cancer Progression by Upregulating MAPK/ERK Signaling. Xie J, Mo T, Li R, Zhang H, Liang G, Ma T, Chen J, Xie H, Wen X, Hu T, Xian Z, Pan W. Cancers (Basel). 2023 Nov 17;15(22):5454. doi: 10.3390/cancers15225454. PubMed |
| Revealing Pan-Histology Immunomodulatory Targets in Pediatric Central Nervous System Tumors. Galvin RT, Jena S, Maeser D, Gruener R, Huang RS. Cancers (Basel). 2023 Nov 17;15(22):5455. doi: 10.3390/cancers15225455. PubMed |
| Adipose-Derived Mesenchymal Stem Cell (MSC) Immortalization by Modulation of hTERT and TP53 Expression Levels. Rakhmatullina AR, Mingaleeva RN, Gafurbaeva DU, Glazunova ON, Sagdeeva AR, Bulatov ER, Rizvanov AA, Miftakhova RR. J Pers Med. 2023 Nov 20;13(11):1621. doi: 10.3390/jpm13111621. PubMed |
| Integrin-alphavbeta3 is a Therapeutically Targetable Fundamental Factor in Medulloblastoma Tumorigenicity and Radioresistance. Echavidre W, Durivault J, Gotorbe C, Blanchard T, Pagnuzzi M, Vial V, Raes F, Broisat A, Villeneuve R, Amblard R, Garnier N, Ortholan C, Faraggi M, Serrano B, Picco V, Montemagno C. Cancer Res Commun. 2023 Dec 7;3(12):2483-2496. doi: 10.1158/2767-9764.CRC-23-0298. PubMed |
| Functional engineering of human iPSC-derived parasympathetic neurons enhances responsiveness to gastrointestinal hormones. Akagi Y, Takayama Y, Nihashi Y, Yamashita A, Yoshida R, Miyamoto Y, Kida YS. FEBS Open Bio. 2024 Jan;14(1):63-78. doi: 10.1002/2211-5463.13741. Epub 2023 Dec 12. PubMed |
| CPT1A induction following epigenetic perturbation promotes MAVS palmitoylation and activation to potentiate antitumor immunity. Zhang G, Jiang P, Tang W, Wang Y, Qiu F, An J, Zheng Y, Wu D, Zhou J, Neculai D, Shi Y, Sheng W. Mol Cell. 2023 Dec 7;83(23):4370-4385.e9. doi: 10.1016/j.molcel.2023.10.043. Epub 2023 Nov 27. PubMed |
| The ELAVL3/MYCN positive feedback loop provides a therapeutic target for neuroendocrine prostate cancer. Ji Y, Zhang W, Shen K, Su R, Liu X, Ma Z, Liu B, Hu C, Xue Y, Xin Z, Yang Y, Li A, Jiang Z, Jing N, Zhu HH, Dong L, Zhu Y, Dong B, Pan J, Wang Q, Xue W. Nat Commun. 2023 Nov 28;14(1):7794. doi: 10.1038/s41467-023-43676-3. PubMed |
| hnRNPA2B1 promotes the occurrence and progression of hepatocellular carcinoma by downregulating PCK1 mRNA via a m6A RNA methylation manner. Hao W, Chen Z, Tang J, Yang R, Gao WQ, Xu H. J Transl Med. 2023 Nov 28;21(1):861. doi: 10.1186/s12967-023-04704-4. PubMed |
| Leucine-rich repeat kinase 2 (LRRK2) inhibition upregulates microtubule-associated protein 1B to ameliorate lysosomal dysfunction and parkinsonism. Chen K, Tang F, Du B, Yue ZZ, Jiao LL, Ding XL, Tuo QZ, Meng J, He SY, Dai L, Lei P, Wei XW. MedComm (2020). 2023 Nov 20;4(6):e429. doi: 10.1002/mco2.429. eCollection 2023 Dec. PubMed |
| Illuminating the mechanism and allosteric behavior of NanoLuc luciferase. Nemergut M, Pluskal D, Horackova J, Sustrova T, Tulis J, Barta T, Baatallah R, Gagnot G, Novakova V, Majerova M, Sedlackova K, Marques SM, Toul M, Damborsky J, Prokop Z, Bednar D, Janin YL, Marek M. Nat Commun. 2023 Nov 29;14(1):7864. doi: 10.1038/s41467-023-43403-y. PubMed |
| UBE2J1 is the E2 ubiquitin-conjugating enzyme regulating androgen receptor degradation and antiandrogen resistance. Rodriguez Tirado C, Wang C, Li X, Deng S, Gonzalez J, Johnson NA, Xu Y, Metang LA, Sundar Rajan M, Yang Y, Yin Y, Hofstad M, Raj GV, Zhang S, Lemoff A, He W, Fan J, Wang Y, Wang T, Mu P. Oncogene. 2024 Jan;43(4):265-280. doi: 10.1038/s41388-023-02890-5. Epub 2023 Nov 29. PubMed |
| The subset of peroxisomal tail-anchored proteins do not reach peroxisomes via ER, instead mitochondria can be involved. Somborac T, Lutfullahoglu Bal G, Fatima K, Vihinen H, Paatero A, Jokitalo E, Paavilainen VO, Konovalova S. PLoS One. 2023 Dec 1;18(12):e0295047. doi: 10.1371/journal.pone.0295047. eCollection 2023. PubMed |
| Clonal heterogeneity in ER+ breast cancer reveals the proteasome and PKC as potential therapeutic targets. Beumers L, Vlachavas EI, Borgoni S, Schwarzmuller L, Penso-Dolfin L, Michels BE, Sofyali E, Burmester S, Heiss D, Wilhelm H, Yarden Y, Helm D, Will R, Goncalves A, Wiemann S. NPJ Breast Cancer. 2023 Dec 2;9(1):97. doi: 10.1038/s41523-023-00604-4. PubMed |
| Enhancer regulatory networks globally connect non-coding breast cancer loci to cancer genes. Wang Y, Armendariz D, Wang L, Zhao H, Xie S, Hon GC. bioRxiv [Preprint]. 2023 Nov 20:2023.11.20.567880. doi: 10.1101/2023.11.20.567880. PubMed |
| The glycoprotein 5 of porcine reproductive and respiratory syndrome virus stimulates mitochondrial ROS to facilitate viral replication. Zhang S, Zeng L, Su B-Q, Yang G-Y, Wang J, Ming S-L, Chu B-B. mBio. 2023 Dec 4;14(6):e0265123. doi: 10.1128/mbio.02651-23. PubMed |
| ZCCHC17 Modulates Neuronal RNA Splicing and Supports Cognitive Resilience in Alzheimer's Disease. Bartosch AMW, Youth EHH, Hansen S, Wu Y, Buchanan HM, Kaufman ME, Xiao H, Koo SY, Ashok A, Sivakumar S, Soni RK, Dumitrescu LC, Lam TG, Ropri AS, Lee AJ, Klein HU, Vardarajan BN, Bennett DA, Young-Pearse TL, De Jager PL, Hohman TJ, Sproul AA, Teich AF. J Neurosci. 2024 Jan 17;44(3):e2324222023. doi: 10.1523/JNEUROSCI.2324-22.2023. PubMed |
| Epidermal growth factor potentiates EGFR(Y992/1173)-mediated therapeutic response of triple negative breast cancer cells to cold atmospheric plasma-activated medium. Wang P, Zhou R, Zhou R, Feng S, Zhao L, Li W, Lin J, Rajapakse A, Lee CH, Furnari FB, Burgess AW, Gunter JH, Liu G, Ostrikov KK, Richard DJ, Simpson F, Dai X, Thompson EW. Redox Biol. 2024 Feb;69:102976. doi: 10.1016/j.redox.2023.102976. Epub 2023 Nov 29. PubMed |
| Secretory GFP reconstitution labeling of neighboring cells interrogates cell-cell interactions in metastatic niches. Minegishi M, Kuchimaru T, Nishikawa K, Isagawa T, Iwano S, Iida K, Hara H, Miura S, Sato M, Watanabe S, Shiomi A, Mabuchi Y, Hamana H, Kishi H, Sato T, Sawaki D, Sato S, Hanazono Y, Suzuki A, Kohro T, Kadonosono T, Shimogori T, Miyawaki A, Takeda N, Shintaku H, Kizaka-Kondoh S, Nishimura S. Nat Commun. 2023 Dec 5;14(1):8031. doi: 10.1038/s41467-023-43855-2. PubMed |
| Leukemia-intrinsic determinants of CAR-T response revealed by iterative in vivo genome-wide CRISPR screening. Ramos A, Koch CE, Liu-Lupo Y, Hellinger RD, Kyung T, Abbott KL, Frose J, Goulet D, Gordon KS, Eidell KP, Leclerc P, Whittaker CA, Larson RC, Muscato AJ, Yates KB, Dubrot J, Doench JG, Regev A, Vander Heiden MG, Maus MV, Manguso RT, Birnbaum ME, Hemann MT. Nat Commun. 2023 Dec 5;14(1):8048. doi: 10.1038/s41467-023-43790-2. PubMed |
| RAD54L2 counters TOP2-DNA adducts to promote genome stability. D'Alessandro G, Morales-Juarez DA, Richards SL, Nitiss KC, Serrano-Benitez A, Wang J, Thomas JC, Gupta V, Voigt A, Belotserkovskaya R, Goh CG, Bowden AR, Galanty Y, Beli P, Nitiss JL, Zagnoli-Vieira G, Jackson SP. Sci Adv. 2023 Dec 8;9(49):eadl2108. doi: 10.1126/sciadv.adl2108. Epub 2023 Dec 6. PubMed |
| Risk model-guided identification of MTDH expression as a marker for ferroptosis induction therapy in head and neck squamous cell carcinoma. Wang X, Gao Y, Miao R, Li L, Nanding A, Liu Y, Zhang X. Am J Cancer Res. 2023 Nov 15;13(11):5236-5253. eCollection 2023. PubMed |
| Epstein-Barr virus induces germinal center light zone chromatin architecture and promotes survival through enhancer looping at the BCL2A1 locus. Dai J, SoRelle ED, Heckenberg E, Song L, Cable JM, Crawford GE, Luftig MA. mBio. 2024 Jan 16;15(1):e0244423. doi: 10.1128/mbio.02444-23. Epub 2023 Dec 7. PubMed |
| BRD4 binds to active cranial neural crest enhancers to regulate RUNX2 activity during osteoblast differentiation. Musa RE, Lester KL, Quickstad G, Vardabasso S, Shumate TV, Salcido RT, Ge K, Shpargel KB. Development. 2024 Jan 15;151(2):dev202110. doi: 10.1242/dev.202110. Epub 2024 Jan 24. PubMed |
| Pediatric glioma histone H3.3 K27M/G34R mutations drive abnormalities in PML nuclear bodies. Voon HPJ, Hii L, Garvie A, Udugama M, Krug B, Russo C, Chueh AC, Daly RJ, Morey A, Bell TDM, Turner SJ, Rosenbluh J, Daniel P, Firestein R, Mann JR, Collas P, Jabado N, Wong LH. Genome Biol. 2023 Dec 8;24(1):284. doi: 10.1186/s13059-023-03122-5. PubMed |
| The MYC-Regulated RNA-Binding Proteins hnRNPC and LARP1 Are Drivers of Multiple Myeloma Cell Growth and Disease Progression and Negatively Predict Patient Survival. Seibert M, Koschade SE, Stolp V, Haupl B, Wempe F, Serve H, Kurrle N, Schnutgen F, von Metzler I. Cancers (Basel). 2023 Nov 21;15(23):5508. doi: 10.3390/cancers15235508. PubMed |
| AA2P-mediated DNA demethylation synergizes with stem cell agonists to promote expansion of hematopoietic stem cells. Manesia JK, Maganti HB, Almoflehi S, Jahan S, Hasan T, Pasha R, McGregor C, Dumont N, Laganiere J, Audet J, Pineault N. Cell Rep Methods. 2023 Dec 18;3(12):100663. doi: 10.1016/j.crmeth.2023.100663. Epub 2023 Dec 8. PubMed |
| RAAS-deficient organoids indicate delayed angiogenesis as a possible cause for autosomal recessive renal tubular dysgenesis. Pode-Shakked N, Slack M, Sundaram N, Schreiber R, McCracken KW, Dekel B, Helmrath M, Kopan R. Nat Commun. 2023 Dec 9;14(1):8159. doi: 10.1038/s41467-023-43795-x. PubMed |
| A high-throughput two-cell assay for interrogating inhibitory signaling pathways in T cells. Sharma S, Whitehead T, Kotowski M, Ng EZQ, Clarke J, Leitner J, Chen YL, Santos AM, Steinberger P, Davis SJ. Life Sci Alliance. 2023 Dec 7;7(3):e202302359. doi: 10.26508/lsa.202302359. Print 2024 Mar. PubMed |
| The formation of ubiquitin rich condensates triggers recruitment of the ATG9A lipid transfer complex to initiate basal autophagy. Broadbent DG, McEwan CM, Tsang TM, Poole DM, Naylor BC, Price JC, Schmidt JC, Andersen JL. bioRxiv [Preprint]. 2023 Nov 29:2023.11.28.569058. doi: 10.1101/2023.11.28.569058. PubMed |
| GRAF1 integrates PINK1-Parkin signaling and actin dynamics to mediate cardiac mitochondrial homeostasis. Zhu Q, Combs ME, Liu J, Bai X, Wang WB, Herring LE, Liu J, Locasale JW, Bowles DE, Gross RT, Pla MM, Mack CP, Taylor JM. Nat Commun. 2023 Dec 11;14(1):8187. doi: 10.1038/s41467-023-43889-6. PubMed |
| Efficient gene editing in induced pluripotent stem cells enabled by an inducible adenine base editor with tunable expression. Nandy K, Babu D, Rani S, Joshi G, Ijee S, George A, Palani D, Premkumar C, Rajesh P, Vijayanand S, David E, Murugesan M, Velayudhan SR. Sci Rep. 2023 Dec 11;13(1):21953. doi: 10.1038/s41598-023-42174-2. PubMed |
Cell type directed design of synthetic enhancers.
Taskiran II, Spanier KI, Dickmanken H, Kempynck N, Pancikova A, Eksi EC, Hulselmans G, Ismail JN, Theunis K, Vandepoel R, Christiaens V, Mauduit D, Aerts S.
Nature. 2023 Dec 12. doi: 10.1038/s41586-023-06936-2.
PubMed
Associated Plasmids |
| The mitochondrial ATP synthase is a negative regulator of the mitochondrial permeability transition pore. Pekson R, Liang FG, Axelrod JL, Lee J, Qin D, Wittig AJH, Paulino VM, Zheng M, Peixoto PM, Kitsis RN. Proc Natl Acad Sci U S A. 2023 Dec 19;120(51):e2303713120. doi: 10.1073/pnas.2303713120. Epub 2023 Dec 13. PubMed |
| Single-Cell Transcriptomics Reveals the Heterogeneity of the Immune Landscape of IDH-Wild-Type High-Grade Gliomas. Ran X, Zheng J, Chen L, Xia Z, Wang Y, Sun C, Guo C, Lin P, Liu F, Wang C, Zhou J, Sun C, Liu Q, Ma J, Qin Z, Zhu X, Xie Q. Cancer Immunol Res. 2024 Feb 2;12(2):232-246. doi: 10.1158/2326-6066.CIR-23-0211. PubMed |
| Enhancing CAR-T cells: unleashing lasting impact potential with phytohemagglutinin activation in in vivo leukemia model. Sert B, Gulden G, Teymur T, Ay Y, Turan RD, Unaldi OM, Guzenge E, Erdil HE, Isik S, Oz P, Bozkurt I, Ozer S, Yurdakul T, Kamali O, Ovali E, Tarhan N, Tastan C. Cancer Gene Ther. 2023 Dec 14. doi: 10.1038/s41417-023-00709-9. PubMed |
Base-editing mutagenesis maps alleles to tune human T cell functions.
Schmidt R, Ward CC, Dajani R, Armour-Garb Z, Ota M, Allain V, Hernandez R, Layeghi M, Xing G, Goudy L, Dorovskyi D, Wang C, Chen YY, Ye CJ, Shy BR, Gilbert LA, Eyquem J, Pritchard JK, Dodgson SE, Marson A.
Nature. 2024 Jan;625(7996):805-812. doi: 10.1038/s41586-023-06835-6. Epub 2023 Dec 13.
PubMed
Associated Plasmids |
| USP13 drives lung squamous cell carcinoma by switching lung club cell lineage plasticity. Kwon J, Zhang J, Mok B, Allsup S, Kim C, Toretsky J, Han C. Mol Cancer. 2023 Dec 13;22(1):204. doi: 10.1186/s12943-023-01892-x. PubMed |
Molecular basis and cellular functions of vinculin-actin directional catch bonding.
Chirasani VR, Khan MAI, Malavade JN, Dokholyan NV, Hoffman BD, Campbell SL.
Nat Commun. 2023 Dec 14;14(1):8300. doi: 10.1038/s41467-023-43779-x.
PubMed
Associated Plasmids |
| PAX3-FOXO1 uses its activation domain to recruit CBP/P300 and shape RNA Pol2 cluster distribution. Asante Y, Benischke K, Osman I, Ngo QA, Wurth J, Laubscher D, Kim H, Udhayakumar B, Khan MIH, Chin DH, Porch J, Chakraborty M, Sallari R, Delattre O, Zaidi S, Morice S, Surdez D, Danielli SG, Schafer BW, Gryder BE, Wachtel M. Nat Commun. 2023 Dec 15;14(1):8361. doi: 10.1038/s41467-023-43780-4. PubMed |
| Microtubule-dependent apical polarization of basement membrane matrix mRNAs in mouse epithelial cells. Wang S, Matsumoto K, Mehlferber MM, Zhang G, Aronova MA, Yamada KM. Cells Dev. 2023 Dec 14;177:203898. doi: 10.1016/j.cdev.2023.203898. PubMed |
| RAPIDASH: A tag-free enrichment of ribosome-associated proteins reveals compositional dynamics in embryonic tissues and stimulated macrophages. Susanto TT, Hung V, Levine AG, Kerr CH, Yoo Y, Chen Y, Oses-Prieto JA, Fromm L, Fujii K, Wernig M, Burlingame AL, Ruggero D, Barna M. bioRxiv [Preprint]. 2023 Dec 7:2023.12.07.570613. doi: 10.1101/2023.12.07.570613. PubMed |
| Stimulation Strength Determined by Superantigen Dose Controls Subcellular Localization of FOXP3 Isoforms and Suppressive Function of CD4+CD25+FOXP3+ T Cells. Lee J, Park N, Nicosia M, Park JY, Pruett SB, Seo KS. J Immunol. 2024 Feb 1;212(3):421-432. doi: 10.4049/jimmunol.2300019. PubMed |
| Engrailed-1 Promotes Pancreatic Cancer Metastasis. Xu J, Roe JS, Lee E, Tonelli C, Ji KY, Younis OW, Somervile TDD, Yao M, Milazzo JP, Tiriac H, Kolarzyk AM, Lee E, Grem JL, Lazenby AJ, Grunkemeyer JA, Hollingsworth MA, Grandgenett PM, Borowsky AD, Park Y, Vakoc CR, Tuveson DA, Hwang CI. Adv Sci (Weinh). 2024 Feb;11(6):e2308537. doi: 10.1002/advs.202308537. Epub 2023 Dec 18. PubMed |
| Generation of novel in vitro flexible kidney organoid model to investigate the role of extracellular vesicles in induction of nephrogenesis. Ahmad N, Samoylenko A, Abene I, Abdelrady E, Zhyvolozhnyi A, Makieieva O, Bart G, Skovorodkin I, Vainio SJ. Cell Commun Signal. 2023 Dec 18;21(1):358. doi: 10.1186/s12964-023-01374-z. PubMed |
| High-throughput deconvolution of 3D organoid dynamics at cellular resolution for cancer pharmacology with Cellos. Mukashyaka P, Kumar P, Mellert DJ, Nicholas S, Noorbakhsh J, Brugiolo M, Courtois ET, Anczukow O, Liu ET, Chuang JH. Nat Commun. 2023 Dec 18;14(1):8406. doi: 10.1038/s41467-023-44162-6. PubMed |
| Neuronal-type-specific epigenome editing to decrease SNCA expression: Implications for precision medicine in synucleinopathies. Sun Z, Kantor B, Chiba-Falek O. Mol Ther Nucleic Acids. 2023 Nov 24;35(1):102084. doi: 10.1016/j.omtn.2023.102084. eCollection 2024 Mar 12. PubMed |
| SARS-CoV-2 NSP14 MTase activity is critical for inducing canonical NF-kappaB activation. Tofaute MJ, Weller B, Grass C, Halder H, Dohai B, Falter-Braun P, Krappmann D. Biosci Rep. 2024 Jan 31;44(1):BSR20231418. doi: 10.1042/BSR20231418. PubMed |
| Chromosome 8p engineering reveals increased metastatic potential targetable by patient-specific synthetic lethality in liver cancer. Huth T, Dreher EC, Lemke S, Fritzsche S, Sugiyanto RN, Castven D, Ibberson D, Sticht C, Eiteneuer E, Jauch A, Pusch S, Albrecht T, Goeppert B, Candia J, Wang XW, Ji J, Marquardt JU, Nahnsen S, Schirmacher P, Roessler S. Sci Adv. 2023 Dec 22;9(51):eadh1442. doi: 10.1126/sciadv.adh1442. Epub 2023 Dec 22. PubMed |
| Altered Treg Infiltration after Discoidin Domain Receptor 1 (DDR1) Inhibition and Knockout Promotes Tumor Growth in Lung Adenocarcinoma. Maitz K, Valadez-Cosmes P, Raftopoulou S, Kindler O, Kienzl M, Bolouri H, Houghton AM, Schicho R, Heinemann A, Kargl J. Cancers (Basel). 2023 Dec 8;15(24):5767. doi: 10.3390/cancers15245767. PubMed |
| Early Emerging SARS-CoV-2 Spike Mutants Are Diversified in Virologic Properties but Elicit Compromised Antibody Responses. Fan J, Li S, Zhang Y, Zheng J, Wang D, Liao Y, Cui Z, Zhao D, Barouch DH, Yu J. Viruses. 2023 Dec 9;15(12):2401. doi: 10.3390/v15122401. PubMed |
| A versatile method for the identification of senolytic compounds. Annunziata C, Castoldi F, Jan S, Ang HX, Ristovska M, Melini S, Welch R, Riedel CG, Pietrocola F. Cell Stress. 2023 Dec 11;7(12):105-111. doi: 10.15698/cst2023.12.292. eCollection 2023 Dec. PubMed |
| An impaired ubiquitin-proteasome system increases APOBEC3A abundance. Coxon M, Dennis MA, Dananberg A, Collins CD, Wilson HE, Meekma J, Savenkova MI, Ng D, Osbron CA, Mertz TM, Goodman AG, Duttke SH, Maciejowski J, Roberts SA. NAR Cancer. 2023 Dec 19;5(4):zcad058. doi: 10.1093/narcan/zcad058. eCollection 2023 Dec. PubMed |
| Endothelial Jagged1 levels and distribution are post-transcriptionally controlled by ZFP36 decay proteins. Sunshine HL, Cicchetto AC, Kaczor-Urbanowicz KE, Ma F, Pi D, Symons C, Turner M, Shukla V, Christofk HR, Vallim TA, Iruela-Arispe ML. Cell Rep. 2024 Jan 23;43(1):113627. doi: 10.1016/j.celrep.2023.113627. Epub 2023 Dec 28. PubMed |
| Impact of eIF2alpha phosphorylation on the translational landscape of mouse embryonic stem cells. Amiri M, Kiniry SJ, Possemato AP, Mahmood N, Basiri T, Dufour CR, Tabatabaei N, Deng Q, Bellucci MA, Harwalkar K, Stokes MP, Giguere V, Kaufman RJ, Yamanaka Y, Baranov PV, Tahmasebi S, Sonenberg N. Cell Rep. 2024 Jan 23;43(1):113615. doi: 10.1016/j.celrep.2023.113615. Epub 2023 Dec 29. PubMed |
| Carcinogenic Role and Clinical Significance of Histone H3-H4 Chaperone Anti-silencing Function 1 B (ASF1B) in Lung Adenocarcinoma. Song C, Song Y, Wan X, Zhao Z, Geng Q. J Cancer. 2024 Jan 1;15(1):218-231. doi: 10.7150/jca.88777. eCollection 2024. PubMed |
| Metabolic reprogramming by histone deacetylase inhibition preferentially targets NRF2-activated tumors. Karagiannis D, Wu W, Li A, Hayashi M, Chen X, Yip M, Mangipudy V, Xu X, Sanchez-Rivera FJ, Soto-Feliciano YM, Ye J, Papagiannakopoulos T, Lu C. Cell Rep. 2024 Jan 23;43(1):113629. doi: 10.1016/j.celrep.2023.113629. Epub 2023 Dec 30. PubMed |
| ARID1A deficiency promotes progression and potentiates therapeutic antitumour immunity in hepatitis B virus-related hepatocellular carcinoma. Xing T, Li L, Rao X, Zhao J, Chen Y, Ju G, Xu Y, Gao X, Dong G, Xia X, Guan Y, Zhang L, Wen Z, Liang J. BMC Gastroenterol. 2024 Jan 2;24(1):11. doi: 10.1186/s12876-023-03059-w. PubMed |
| Pharmaceutical targeting of OTUB2 sensitizes tumors to cytotoxic T cells via degradation of PD-L1. Ren W, Xu Z, Chang Y, Ju F, Wu H, Liang Z, Zhao M, Wang N, Lin Y, Xu C, Chen S, Rao Y, Lin C, Yang J, Liu P, Zhang J, Huang C, Xia N. Nat Commun. 2024 Jan 2;15(1):9. doi: 10.1038/s41467-023-44466-7. PubMed |
| Mcam inhibits macrophage-mediated development of mammary gland through non-canonical Wnt signaling. Yang X, Xu H, Yang X, Wang H, Zou L, Yang Q, Qi X, Li L, Duan H, Yan X, Fu NY, Tan J, Hou Z, Jiao B. Nat Commun. 2024 Jan 2;15(1):36. doi: 10.1038/s41467-023-44338-0. PubMed |
| Tubeimosides are pan-coronavirus and filovirus inhibitors that can block their fusion protein binding to Niemann-Pick C1. Khan I, Li S, Tao L, Wang C, Ye B, Li H, Liu X, Ahmad I, Su W, Zhong G, Wen Z, Wang J, Hua RH, Ma A, Liang J, Wan XP, Bu ZG, Zheng YH. Nat Commun. 2024 Jan 2;15(1):162. doi: 10.1038/s41467-023-44504-4. PubMed |
| Direct effects of adipocyte lipolysis on AMPK through intracellular long-chain acyl-CoA signaling. Rahman AA, Butcko AJ, Songyekutu E, Granneman JG, Mottillo EP. Sci Rep. 2024 Jan 2;14(1):19. doi: 10.1038/s41598-023-50903-w. PubMed |
| Integrated multi-omics analyses identify anti-viral host factors and pathways controlling SARS-CoV-2 infection. Hou J, Wei Y, Zou J, Jaffery R, Sun L, Liang S, Zheng N, Guerrero AM, Egan NA, Bohat R, Chen S, Zheng C, Mao X, Yi SS, Chen K, McGrail DJ, Sahni N, Shi PY, Chen Y, Xie X, Peng W. Nat Commun. 2024 Jan 2;15(1):109. doi: 10.1038/s41467-023-44175-1. PubMed |
| Surplus fatty acid synthesis increases oxidative stress in adipocytes and lnduces lipodystrophy. Weng L, Tang WS, Wang X, Gong Y, Liu C, Hong NN, Tao Y, Li KZ, Liu SN, Jiang W, Li Y, Yao K, Chen L, Huang H, Zhao YZ, Hu ZP, Lu Y, Ye H, Du X, Zhou H, Li P, Zhao TJ. Nat Commun. 2024 Jan 2;15(1):133. doi: 10.1038/s41467-023-44393-7. PubMed |
| GSK3 inhibition reduces ECM production and prevents age-related macular degeneration-like pathology. DiCesare SM, Ortega AJ, Collier GE, Daniel S, Thompson KN, McCoy MK, Posner BA, Hulleman JD. bioRxiv [Preprint]. 2023 Dec 15:2023.12.14.571757. doi: 10.1101/2023.12.14.571757. PubMed |
| Host E3 ubiquitin ligase ITCH mediates Toxoplasma gondii effector GRA35-triggered NLRP1 inflammasome activation and cell-autonomous immunity. Wang Y, Hollingsworth LR, Sangare LO, Paredes-Santos TC, Krishnamurthy S, Penn BH, Wu H, Saeij JPJ. bioRxiv [Preprint]. 2023 Dec 14:2023.12.13.571530. doi: 10.1101/2023.12.13.571530. PubMed |
Large-scale evaluation of the ability of RNA-binding proteins to activate exon inclusion.
Schmok JC, Jain M, Street LA, Tankka AT, Schafer D, Her HL, Elmsaouri S, Gosztyla ML, Boyle EA, Jagannatha P, Luo EC, Kwon EJ, Jovanovic M, Yeo GW.
Nat Biotechnol. 2024 Jan 2. doi: 10.1038/s41587-023-02014-0.
PubMed
Associated Plasmids |
| Ultrafast bisulfite sequencing detection of 5-methylcytosine in DNA and RNA. Dai Q, Ye C, Irkliyenko I, Wang Y, Sun HL, Gao Y, Liu Y, Beadell A, Perea J, Goel A, He C. Nat Biotechnol. 2024 Jan 2. doi: 10.1038/s41587-023-02034-w. PubMed |
| N-acetyltransferase 10 regulates alphavirus replication via N4-acetylcytidine (ac4C) modi fi cation of the lymphocyte antigen six family member E (LY6E) mRNA. Dang Y, Li J, Li Y, Wang Y, Zhao Y, Zhao N, Li W, Zhang H, Ye C, Ma H, Zhang L, Liu H, Dong Y, Yao M, Lei Y, Xu Z, Zhang F, Ye W. J Virol. 2024 Jan 23;98(1):e0135023. doi: 10.1128/jvi.01350-23. Epub 2024 Jan 3. PubMed |
| Cyclical palmitoylation regulates TLR9 signalling and systemic autoimmunity in mice. Ni H, Wang Y, Yao K, Wang L, Huang J, Xiao Y, Chen H, Liu B, Yang CY, Zhao J. Nat Commun. 2024 Jan 2;15(1):1. doi: 10.1038/s41467-023-43650-z. PubMed |
| Pharmacological inhibition of MYC to mitigate chemoresistance in preclinical models of squamous cell carcinoma. Liu S, Qin Z, Mao Y, Wang N, Zhang W, Wang Y, Chen Y, Jia L, Peng X. Theranostics. 2024 Jan 1;14(2):622-639. doi: 10.7150/thno.88759. eCollection 2024. PubMed |
| Transcriptional determinants of lipid mobilization in human adipocytes. Ludzki AC, Hansen M, Zareifi D, Jalkanen J, Huang Z, Omar-Hmeadi M, Renzi G, Klingelhuber F, Boland S, Ambaw YA, Wang N, Damdimopoulos A, Liu J, Jernberg T, Petrus P, Arner P, Krahmer N, Fan R, Treuter E, Gao H, Ryden M, Mejhert N. Sci Adv. 2024 Jan 5;10(1):eadi2689. doi: 10.1126/sciadv.adi2689. Epub 2024 Jan 3. PubMed |
| The low-density lipoprotein receptor promotes infection of multiple encephalitic alphaviruses. Ma H, Adams LJ, Raju S, Sariol A, Kafai NM, Janova H, Klimstra WB, Fremont DH, Diamond MS. Nat Commun. 2024 Jan 4;15(1):246. doi: 10.1038/s41467-023-44624-x. PubMed |
| Acellular scaffold-based approach for in situ genetic engineering of host T-cells in solid tumor immunotherapy. Dandia HY, Pillai MM, Sharma D, Suvarna M, Dalal N, Madhok A, Ingle A, Chiplunkar SV, Galande S, Tayalia P. Mil Med Res. 2024 Jan 4;11(1):3. doi: 10.1186/s40779-023-00503-6. PubMed |
| Hepatitis C virus E1 recruits high-density lipoprotein to support infectivity and evade antibody recognition. Casiano Matos J, Harichandran K, Tang J, Sviridov DO, Sidoti Migliore G, Suzuki M, Olano LR, Hobbs A, Kumar A, Paskel MU, Bonsignori M, Dearborn AD, Remaley AT, Marcotrigiano J. J Virol. 2024 Jan 23;98(1):e0084923. doi: 10.1128/jvi.00849-23. Epub 2024 Jan 4. PubMed |
| Targeting cancer-associated fibroblast autophagy renders pancreatic cancer eradicable with immunochemotherapy by inhibiting adaptive immune resistance. Zhang X, Lao M, Yang H, Sun K, Dong Y, He L, Jiang X, Wu H, Jiang Y, Li M, Ying H, Liu X, Xu J, Chen Y, Zhang H, Zhou R, Gao J, Bai X, Liang T. Autophagy. 2024 Jan 4:1-21. doi: 10.1080/15548627.2023.2300913. PubMed |
| Structural and functional basis of VLDLR usage by Eastern equine encephalitis virus. Adams LJ, Raju S, Ma H, Gilliland T Jr, Reed DS, Klimstra WB, Fremont DH, Diamond MS. Cell. 2024 Jan 18;187(2):360-374.e19. doi: 10.1016/j.cell.2023.11.031. Epub 2024 Jan 3. PubMed |
| Nuclear membrane protein SUN2 promotes replication of flaviviruses through modulating cytoskeleton reorganization mediated by NS1. Huang Y, Peng Q, Tian X, Chen C, Zhu X, Huang C, Huo Z, Liu Y, Yang C, Liu C, Zhang P. Nat Commun. 2024 Jan 5;15(1):296. doi: 10.1038/s41467-023-44580-6. PubMed |
| Bivalent activity of super-enhancer RNA LINC02454 controls 3D chromatin structure and regulates glioma sensitivity to temozolomide. Shi T, Guo D, Zheng Y, Wang W, Bi J, He A, Fan S, Su G, Zhao X, Zhao Z, Song Y, Sun S, Li P, Zhao Z, Shi J, Lu W, Zhang L. Cell Death Dis. 2024 Jan 4;15(1):6. doi: 10.1038/s41419-023-06392-w. PubMed |
| Shaping immune landscape of colorectal cancer by cholesterol metabolites. Bai Y, Li T, Wang Q, You W, Yang H, Xu X, Li Z, Zhang Y, Yan C, Yang L, Qiu J, Liu Y, Chen S, Wang D, Huang B, Liu K, Song BL, Wang Z, Li K, Liu X, Wang G, Yang W, Chen J, Hao P, Zhang Z, Wang Z, Zhu ZJ, Xu C. EMBO Mol Med. 2024 Feb;16(2):334-360. doi: 10.1038/s44321-023-00015-9. Epub 2024 Jan 2. PubMed |
| The mosquito effect: regulatory and effector T cells acquire cytoplasmic material from tumor cells through intercellular transfer. Hioki KA, Ryan DJ, Thesmar I, Lynch AC, Pobezinsky LA, Pobezinskaya EL. Front Immunol. 2023 Dec 20;14:1272918. doi: 10.3389/fimmu.2023.1272918. eCollection 2023. PubMed |
| Kaposi's sarcoma herpesvirus exploits the DNA damage response to circularize its genome. Li S, Liu B, Tan M, Juillard F, Szymula A, Alvarez AL, Van Sciver N, George A, Ramachandran A, Raina K, Tumuluri VS, Costa CN, Simas JP, Kaye KM. Nucleic Acids Res. 2024 Feb 28;52(4):1814-1829. doi: 10.1093/nar/gkad1224. PubMed |
| Interferon-stimulated neutrophils as a predictor of immunotherapy response. Benguigui M, Cooper TJ, Kalkar P, Schif-Zuck S, Halaban R, Bacchiocchi A, Kamer I, Deo A, Manobla B, Menachem R, Haj-Shomaly J, Vorontsova A, Raviv Z, Buxbaum C, Christopoulos P, Bar J, Lotem M, Sznol M, Ariel A, Shen-Orr SS, Shaked Y. Cancer Cell. 2024 Feb 12;42(2):253-265.e12. doi: 10.1016/j.ccell.2023.12.005. Epub 2024 Jan 4. PubMed |
| Akt activation ameliorates deficits in hippocampal-dependent memory and activity-dependent synaptic protein synthesis in an Alzheimer's disease mouse model. Kommaddi RP, Gowaikar R, P A H, Diwakar L, Singh K, Mondal A. J Biol Chem. 2024 Feb;300(2):105619. doi: 10.1016/j.jbc.2023.105619. Epub 2024 Jan 3. PubMed |
| Direct translation of incoming retroviral genomes. Koppke J, Keller LE, Stuck M, Arnow ND, Bannert N, Doellinger J, Cingoz O. Nat Commun. 2024 Jan 5;15(1):299. doi: 10.1038/s41467-023-44501-7. PubMed |
| Two somatic mutations in the androgen receptor N-terminal domain are oncogenic drivers in hepatocellular carcinoma. Ren QN, Huang DH, Zhang XN, Wang YN, Zhou YF, Zhang MY, Wang SC, Mai SJ, Wu DH, Wang HY. Commun Biol. 2024 Jan 5;7(1):22. doi: 10.1038/s42003-023-05704-2. PubMed |
| R-spondin-1 induces Axin degradation via the LRP6-CK1epsilon axis. Tan L, Yan M, Su Z, Wang H, Li H, Zhao X, Liu S, Zhang L, Sun Q, Lu D. Cell Commun Signal. 2024 Jan 5;22(1):14. doi: 10.1186/s12964-023-01456-y. PubMed |
| Fatty acid amide hydrolase drives adult mammary gland development by promoting luminal cell differentiation. Tundidor I, Seijo-Vila M, Blasco-Benito S, Rubert-Hernandez M, Moreno-Bueno G, Bindila L, de la Rosa RF, Guzman M, Sanchez C, Perez-Gomez E. Cell Death Discov. 2024 Jan 6;10(1):12. doi: 10.1038/s41420-023-01788-1. PubMed |
| DMT1-dependent endosome-mitochondria interactions regulate mitochondrial iron translocation and metastatic outgrowth. Barra J, Crosbourne I, Roberge CL, Bossardi-Ramos R, Warren JSA, Matteson K, Wang L, Jourd'heuil F, Borisov SM, Bresnahan E, Bravo-Cordero JJ, Dmitriev RI, Jourd'heuil D, Adam AP, Lamar JM, Corr DT, Barroso MM. Oncogene. 2024 Feb;43(9):650-667. doi: 10.1038/s41388-023-02933-x. Epub 2024 Jan 6. PubMed |
| TDP-43 chronic deficiency leads to dysregulation of transposable elements and gene expression by affecting R-loop and 5hmC crosstalk. Hou Y, Li Y, Xiang JF, Tilahun K, Jiang J, Corces VG, Yao B. Cell Rep. 2024 Jan 23;43(1):113662. doi: 10.1016/j.celrep.2023.113662. Epub 2024 Jan 6. PubMed |
| ATP7A-dependent copper sequestration contributes to termination of beta-CATENIN signaling during early adipogenesis. Yang H, Kabin E, Dong Y, Zhang X, Ralle M, Lutsenko S. Mol Metab. 2024 Feb;80:101872. doi: 10.1016/j.molmet.2024.101872. Epub 2024 Jan 6. PubMed |
| Trans-synaptic molecular context of NMDA receptor nanodomains. Anderson MC, Levy AD, Dharmasri PA, Metzbower SR, Blanpied TA. bioRxiv [Preprint]. 2023 Dec 23:2023.12.22.573055. doi: 10.1101/2023.12.22.573055. PubMed |
| The role of satellite cell-derived TRIM28 in mechanical load- and injury-induced myogenesis. Lin KH, Hibbert JE, Lemens JL, Torbey MM, Steinert ND, Flejsierowicz PM, Melka KM, Lares M, Setaluri V, Hornberger TA. bioRxiv [Preprint]. 2023 Dec 29:2023.12.20.572566. doi: 10.1101/2023.12.20.572566. PubMed |
| Duchenne muscular dystrophy treatment with lentiviral vector containing mini-dystrophin gene in vivo. Wang X, Zhu Y, Liu T, Zhou L, Fu Y, Zhao J, Li Y, Zheng Y, Yang X, Di X, Yang Y, He Z. MedComm (2020). 2024 Jan 6;5(1):e423. doi: 10.1002/mco2.423. eCollection 2024 Jan. PubMed |
| Modulations in the host cell proteome by the hantavirus nucleocapsid protein. Royster A, Ren S, Ali S, Mir S, Mir M. PLoS Pathog. 2024 Jan 8;20(1):e1011925. doi: 10.1371/journal.ppat.1011925. eCollection 2024 Jan. PubMed |
| Chemoproteomic development of SLC15A4 inhibitors with anti-inflammatory activity. Chiu TY, Lazar DC, Wang WW, Wozniak JM, Jadhav AM, Li W, Gazaniga N, Theofilopoulos AN, Teijaro JR, Parker CG. Nat Chem Biol. 2024 Aug;20(8):1000-1011. doi: 10.1038/s41589-023-01527-8. Epub 2024 Jan 8. PubMed |
| Targeted Protein Degradation through Recruitment of the CUL4 Complex Adaptor Protein DDB1. Meyers M, Cismoski S, Panidapu A, Chie-Leon B, Nomura DK. ACS Chem Biol. 2024 Jan 19;19(1):58-68. doi: 10.1021/acschembio.3c00487. Epub 2024 Jan 8. PubMed |
| Suppression of NBS1 Upregulates CyclinB to Induce Olaparib Sensitivity in Ovarian Cancer. Zhong A, Cheng CS, Lu RQ, Guo L. Technol Cancer Res Treat. 2024 Jan-Dec;23:15330338231212085. doi: 10.1177/15330338231212085. PubMed |
| Distinct spatiotemporal dynamics of CD8(+) T cell-derived cytokines in the tumor microenvironment. Hoekstra ME, Slagter M, Urbanus J, Toebes M, Slingerland N, de Rink I, Kluin RJC, Nieuwland M, Kerkhoven R, Wessels LFA, Schumacher TN. Cancer Cell. 2024 Jan 8;42(1):157-167.e9. doi: 10.1016/j.ccell.2023.12.010. PubMed |
| Computational prediction and experimental validation identify functionally conserved lncRNAs from zebrafish to human. Huang W, Xiong T, Zhao Y, Heng J, Han G, Wang P, Zhao Z, Shi M, Li J, Wang J, Wu Y, Liu F, Xi JJ, Wang Y, Zhang QC. Nat Genet. 2024 Jan;56(1):124-135. doi: 10.1038/s41588-023-01620-7. Epub 2024 Jan 9. PubMed |
| Passenger Gene Coamplifications Create Collateral Therapeutic Vulnerabilities in Cancer. Bei Y, Brame L, Kirchner M, Fritsche-Guenther R, Kunz S, Bhattacharya A, Rusu MC, Gurgen D, Dubios FPB, Koppke JKC, Proba J, Wittstruck N, Sidorova OA, Chamorro Gonzalez R, Dorado Garcia H, Bruckner L, Xu R, Giurgiu M, Rodriguez-Fos E, Yu Q, Spanjaard B, Koche RP, Schmitt CA, Schulte JH, Eggert A, Haase K, Kirwan J, Hagemann AIH, Mertins P, Dorr JR, Henssen AG. Cancer Discov. 2024 Mar 1;14(3):492-507. doi: 10.1158/2159-8290.CD-23-1189. PubMed |
METTL17 is an Fe-S cluster checkpoint for mitochondrial translation.
Ast T, Itoh Y, Sadre S, McCoy JG, Namkoong G, Wengrod JC, Chicherin I, Joshi PR, Kamenski P, Suess DLM, Amunts A, Mootha VK.
Mol Cell. 2024 Jan 18;84(2):359-374.e8. doi: 10.1016/j.molcel.2023.12.016. Epub 2024 Jan 9.
PubMed
Associated Plasmids |
| LATS2 condensates organize signalosomes for Hippo pathway signal transduction. Qin M, Geng E, Wang J, Yu M, Dong T, Li S, Zhang X, Lin J, Shi M, Li J, Zhang H, Chen L, Cao X, Huang L, Wang M, Li Y, Yang XP, Zhao B, Sun S. Nat Chem Biol. 2024 Jan 10. doi: 10.1038/s41589-023-01516-x. PubMed |
MRE11 liberates cGAS from nucleosome sequestration during tumorigenesis.
Cho MG, Kumar RJ, Lin CC, Boyer JA, Shahir JA, Fagan-Solis K, Simpson DA, Fan C, Foster CE, Goddard AM, Lerner LM, Ellington SW, Wang Q, Wang Y, Ho AY, Liu P, Perou CM, Zhang Q, McGinty RK, Purvis JE, Gupta GP.
Nature. 2024 Jan 10. doi: 10.1038/s41586-023-06889-6.
PubMed
Associated Plasmids |
| Transforming Growth Factor-beta/Smad Signaling Inhibits Melanoma Cancer Stem Cell Self-Renewal, Tumor Formation and Metastasis. Boudreault J, Wang N, Ghozlan M, Lebrun JJ. Cancers (Basel). 2024 Jan 3;16(1):224. doi: 10.3390/cancers16010224. PubMed |
| Activation of Young LINE-1 Elements by CRISPRa. Tong B, Sun Y. Int J Mol Sci. 2023 Dec 28;25(1):424. doi: 10.3390/ijms25010424. PubMed |
| TALK-1-mediated alterations of beta-cell mitochondrial function and insulin secretion impair glucose homeostasis on a diabetogenic diet. Graff SM, Nakhe AY, Dadi PK, Dickerson MT, Dobson JR, Zaborska KE, Ibsen CE, Butterworth RB, Vierra NC, Jacobson DA. Cell Rep. 2024 Jan 23;43(1):113673. doi: 10.1016/j.celrep.2024.113673. Epub 2024 Jan 10. PubMed |
| EBV abortive lytic cycle promotes nasopharyngeal carcinoma progression through recruiting monocytes and regulating their directed differentiation. Xu X, Zhu N, Zheng J, Peng Y, Zeng MS, Deng K, Duan C, Yuan Y. PLoS Pathog. 2024 Jan 11;20(1):e1011934. doi: 10.1371/journal.ppat.1011934. eCollection 2024 Jan. PubMed |
Pioneer and PRDM transcription factors coordinate bivalent epigenetic states to safeguard cell fate.
Matsui S, Granitto M, Buckley M, Ludwig K, Koigi S, Shiley J, Zacharias WJ, Mayhew CN, Lim HW, Iwafuchi M.
Mol Cell. 2024 Jan 4:S1097-2765(23)01026-2. doi: 10.1016/j.molcel.2023.12.007.
PubMed
Associated Plasmids |
| Disordered-to-ordered transitions in assembly factors allow the complex II catalytic subunit to switch binding partners. Sharma P, Maklashina E, Voehler M, Balintova S, Dvorakova S, Kraus M, Vanova KH, Nahacka Z, Zobalova R, Boukalova S, Cunatova K, Mracek T, Ghayee HK, Pacak K, Rohlena J, Neuzil J, Cecchini G, Iverson TM. Nat Commun. 2024 Jan 11;15(1):473. doi: 10.1038/s41467-023-44563-7. PubMed |
| TKT-PARP1 axis induces radioresistance by promoting DNA double-strand break repair in hepatocellular carcinoma. Geng L, Zhu M, Luo D, Chen H, Li B, Lao Y, An H, Wu Y, Li Y, Xia A, Shi Y, Tong Z, Lu S, Xu D, Wang X, Zhang W, Sun B, Xu Z. Oncogene. 2024 Feb;43(9):682-692. doi: 10.1038/s41388-023-02935-9. Epub 2024 Jan 12. PubMed |
| Generation and optimization of off-the-shelf immunotherapeutics targeting TCR-Vbeta2+ T cell malignancy. Ren J, Liao X, Lewis JM, Chang J, Qu R, Carlson KR, Foss F, Girardi M. Nat Commun. 2024 Jan 15;15(1):519. doi: 10.1038/s41467-024-44786-2. PubMed |
| Ribogenesis boosts controlled by HEATR1-MYC interplay promote transition into brain tumour growth. Diaz LR, Gil-Ranedo J, Jaworek KJ, Nsek N, Marques JP, Costa E, Hilton DA, Bieluczyk H, Warrington O, Hanemann CO, Futschik ME, Bossing T, Barros CS. EMBO Rep. 2024 Jan;25(1):168-197. doi: 10.1038/s44319-023-00017-1. Epub 2024 Jan 15. PubMed |
| Intrahepatic homeobox protein MSX-1 is a novel host restriction factor of hepatitis B virus. Shen Z, Zhang S, Gao Z, Yu X, Wang J, Pan S, Kang N, Liu N, Xu H, Liu M, Yang Y, Deng Q, Liu J, Xie Y, Zhang J. J Virol. 2024 Feb 20;98(2):e0134523. doi: 10.1128/jvi.01345-23. Epub 2024 Jan 16. PubMed |
| The dimeric deubiquitinase USP28 integrates 53BP1 and MYC functions to limit DNA damage. Jin C, Einig E, Xu W, Kollampally RB, Schlosser A, Flentje M, Popov N. Nucleic Acids Res. 2024 Apr 12;52(6):3011-3030. doi: 10.1093/nar/gkae004. PubMed |
| Nucleolar protein TAAP1/C22orf46 confers pro-survival signaling in non-small cell lung cancer. Doring M, Brux M, Paszkowski-Rogacz M, Guillem-Gloria PM, Buchholz F, Pisabarro MT, Theis M. Life Sci Alliance. 2024 Jan 16;7(4):e202302257. doi: 10.26508/lsa.202302257. Print 2024 Apr. PubMed |
| BMP-ACVR1 Axis is Critical for Efficacy of PRC2 Inhibitors in B-Cell Lymphoma. Liu D, Li Z, Tan D, An Y, Chu L, Chen T, Li W, Zhou A, Xiang R, Zhang L, Qu Y, Qi W. Adv Sci (Weinh). 2024 Mar;11(12):e2306499. doi: 10.1002/advs.202306499. Epub 2024 Jan 16. PubMed |
| Neuronal MAPT expression is mediated by long-range interactions with cis-regulatory elements. Rogers BB, Anderson AG, Lauzon SN, Davis MN, Hauser RM, Roberts SC, Rodriguez-Nunez I, Trausch-Lowther K, Barinaga EA, Hall PI, Knuesel MT, Taylor JW, Mackiewicz M, Roberts BS, Cooper SJ, Rizzardi LF, Myers RM, Cochran JN. Am J Hum Genet. 2024 Feb 1;111(2):259-279. doi: 10.1016/j.ajhg.2023.12.015. Epub 2024 Jan 16. PubMed |
| c-Fos regulated by TMPO/ERK axis promotes 5-FU resistance via inducing NANOG transcription in colon cancer. Gui Y, Qian X, Ding Y, Chen Q, Fangyu Ye, Ye Y, Hou Y, Yu J, Zhao L. Cell Death Dis. 2024 Jan 17;15(1):61. doi: 10.1038/s41419-024-06451-w. PubMed |
| Alternative splicing of latrophilin-3 controls synapse formation. Wang S, DeLeon C, Sun W, Quake SR, Roth BL, Sudhof TC. Nature. 2024 Feb;626(7997):128-135. doi: 10.1038/s41586-023-06913-9. Epub 2024 Jan 17. PubMed |
| Contribution of CENP-F to FOXM1-mediated discordant centromere and kinetochore transcriptional regulation. Khurana S, Foltz DR. bioRxiv [Preprint]. 2023 Dec 27:2023.12.27.573453. doi: 10.1101/2023.12.27.573453. PubMed |
| SUMOylation of the m6A reader YTHDF2 by PIAS1 promotes viral RNA decay to restrict EBV replication. Sugiokto FG, Saiada F, Zhang K, Li R. mBio. 2024 Feb 14;15(2):e0316823. doi: 10.1128/mbio.03168-23. Epub 2024 Jan 18. PubMed |
| Recruitment of BAG2 to DNAJ-PKAc scaffolds promotes cell survival and resistance to drug-induced apoptosis in fibrolamellar carcinoma. Lauer SM, Omar MH, Golkowski MG, Kenerson HL, Lee KS, Pascual BC, Lim HC, Forbush K, Smith FD, Gordan JD, Ong SE, Yeung RS, Scott JD. Cell Rep. 2024 Feb 27;43(2):113678. doi: 10.1016/j.celrep.2024.113678. Epub 2024 Jan 17. PubMed |
| USP22 overexpression fails to augment tumor formation in MMTV-ERBB2 mice but loss of function impacts MMTV promoter activity. Kuang X, Salinger A, Benavides F, Muller WJ, Dent SYR, Koutelou E. PLoS One. 2024 Jan 18;19(1):e0290837. doi: 10.1371/journal.pone.0290837. eCollection 2024. PubMed |
| A novel antagonist of the CCL5/CCR5 axis suppresses the tumor growth and metastasis of triple-negative breast cancer by CCR5-YAP1 regulation. Chen L, Xu G, Song X, Zhang L, Chen C, Xiang G, Wang S, Zhang Z, Wu F, Yang X, Zhang L, Ma X, Yu J. Cancer Lett. 2024 Feb 28;583:216635. doi: 10.1016/j.canlet.2024.216635. Epub 2024 Jan 17. PubMed |
| HIV-1 Capsid Uncoating Is a Multistep Process That Proceeds through Defect Formation Followed by Disassembly of the Capsid Lattice. Gifford LB, Melikyan GB. ACS Nano. 2024 Jan 30;18(4):2928-2947. doi: 10.1021/acsnano.3c07678. Epub 2024 Jan 19. PubMed |
| SPOP negatively regulates mTORC1 activity by ubiquitinating Sec13. Yang Y, Han YC, Cao Q, Wang X, Wei XD, Shang MD, Zhang XG, Li X, Hu B, Tian CY, Yang ZL, Liu KH, Wang JQ. Cell Signal. 2024 Apr;116:111060. doi: 10.1016/j.cellsig.2024.111060. Epub 2024 Jan 17. PubMed |
| The CUL5 E3 ligase complex negatively regulates central signaling pathways in CD8(+) T cells. Liao X, Li W, Zhou H, Rajendran BK, Li A, Ren J, Luan Y, Calderwood DA, Turk B, Tang W, Liu Y, Wu D. Nat Commun. 2024 Jan 19;15(1):603. doi: 10.1038/s41467-024-44885-0. PubMed |
| CircNUP50 is a novel therapeutic target that promotes cisplatin resistance in ovarian cancer by modulating p53 ubiquitination. Zhu Y, Liang L, Zhao Y, Li J, Zeng J, Yuan Y, Li N, Wu L. J Nanobiotechnology. 2024 Jan 19;22(1):35. doi: 10.1186/s12951-024-02295-w. PubMed |
| LDLR is used as a cell entry receptor by multiple alphaviruses. Zhai X, Li X, Veit M, Wang N, Wang Y, Merits A, Jiang Z, Qin Y, Zhang X, Qi K, Jiao H, He WT, Chen Y, Mao Y, Su S. Nat Commun. 2024 Jan 20;15(1):622. doi: 10.1038/s41467-024-44872-5. PubMed |
| Proteomic analysis of SARS-CoV-2 particles unveils a key role of G3BP proteins in viral assembly. Murigneux E, Softic L, Aube C, Grandi C, Judith D, Bruce J, Le Gall M, Guillonneau F, Schmitt A, Parissi V, Berlioz-Torrent C, Meertens L, Hansen MMK, Gallois-Montbrun S. Nat Commun. 2024 Jan 20;15(1):640. doi: 10.1038/s41467-024-44958-0. PubMed |
| LUBAC-mediated M1 Ub regulates necroptosis by segregating the cellular distribution of active MLKL. Weinelt N, Wachtershauser KN, Celik G, Jeiler B, Gollin I, Zein L, Smith S, Andrieux G, Das T, Roedig J, Feist L, Rotter B, Boerries M, Pampaloni F, van Wijk SJL. Cell Death Dis. 2024 Jan 20;15(1):77. doi: 10.1038/s41419-024-06447-6. PubMed |
| Vutiglabridin Alleviates Cellular Senescence with Metabolic Regulation and Circadian Clock in Human Dermal Fibroblasts. Heo JW, Lee HE, Lee J, Choi LS, Shin J, Mun JY, Park HS, Park SC, Nam CH. Antioxidants (Basel). 2024 Jan 16;13(1):109. doi: 10.3390/antiox13010109. PubMed |
| A Novel Anti-CD47 Nanobody Tetramer for Cancer Therapy. Ratnikova NM, Kravchenko Y, Ivanova A, Zhuchkov V, Frolova E, Chumakov S. Antibodies (Basel). 2024 Jan 2;13(1):2. doi: 10.3390/antib13010002. PubMed |
| TGFbeta and Hippo Signaling Pathways Coordinate to Promote Acinar to Ductal Metaplasia in Human Pancreas. Nipper M, Xu Y, Liu J, Yin X, Liu Z, Ye Z, Zhang J, Chen Y, Wang P. Cells. 2024 Jan 18;13(2):186. doi: 10.3390/cells13020186. PubMed |
| OPN promotes pro-inflammatory cytokine expression via ERK/JNK pathway and M1 macrophage polarization in Rosacea. Tang S, Hu H, Li M, Zhang K, Wu Q, Liu X, Wu L, Yu B, Chen X. Front Immunol. 2024 Jan 5;14:1285951. doi: 10.3389/fimmu.2023.1285951. eCollection 2023. PubMed |
| KLRG1 Cell Depletion as a Novel Therapeutic Strategy in Patients with Mature T-Cell Lymphoma Subtypes. Assatova B, Willim R, Trevisani C, Haskett G, Kariya KM, Chopra K, Park SR, Tolstorukov MY, McCabe SM, Duffy J, Louissaint A Jr, Huuhtanen J, Bhattacharya D, Mustjoki S, Koh MJ, Powers F, Morgan EA, Yang L, Pinckney B, Cotton MJ, Crabbe A, Ziemba JB, Brain I, Heavican-Foral TB, Iqbal J, Nemec R, Rider AB, Ford JG, Koh MJ, Scanlan N, Feith DJ, Loughran TP Jr, Kim WS, Choi J, Roels J, Boehme L, Putteman T, Taghon T, Barnes JA, Johnson PC, Jacobsen ED, Greenberg SA, Weinstock DM, Jain S. Clin Cancer Res. 2024 Jun 3;30(11):2514-2530. doi: 10.1158/1078-0432.CCR-23-3504. PubMed |
| Multi-Omics Profiling Identifies Microglial Annexin A2 as a Key Mediator of NF-kappaB Pro-inflammatory Signaling in Ischemic Reperfusion Injury. Tian X, Yang W, Jiang W, Zhang Z, Liu J, Tu H. Mol Cell Proteomics. 2024 Feb;23(2):100723. doi: 10.1016/j.mcpro.2024.100723. Epub 2024 Jan 20. PubMed |
| Unexpected inhibition of the lipid kinase PIKfyve reveals an epistatic role for p38 MAPKs in endolysosomal fission and volume control. Wible DJ, Parikh Z, Cho EJ, Chen MD, Jeter CR, Mukhopadhyay S, Dalby KN, Varadarajan S, Bratton SB. Cell Death Dis. 2024 Jan 22;15(1):80. doi: 10.1038/s41419-024-06423-0. PubMed |
| Hydroxynorketamine, but not ketamine, acts via alpha7 nicotinic acetylcholine receptor to control presynaptic function and gene expression. Guhathakurta D, Petruskova A, Akdas EY, Perello-Amoros B, Frischknecht R, Anni D, Weiss EM, Walter M, Fejtova A. Transl Psychiatry. 2024 Jan 22;14(1):47. doi: 10.1038/s41398-024-02744-y. PubMed |
| PD-1 signaling uncovers a pathogenic subset of T cells in inflammatory arthritis. Straube J, Bukhari S, Lerrer S, Winchester RJ, Gartshteyn Y, Henick BS, Dragovich MA, Mor A. Arthritis Res Ther. 2024 Jan 22;26(1):32. doi: 10.1186/s13075-023-03259-5. PubMed |
| Transcription Factor SATB2 Regulates Skeletal Muscle Cell Proliferation and Migration via HDAC4 in Pigs. Li F, Yan C, Yao Y, Yang Y, Liu Y, Fan D, Zhao J, Tang Z. Genes (Basel). 2024 Jan 2;15(1):65. doi: 10.3390/genes15010065. PubMed |
| HPV16 E6 Oncogene Contributes to Cancer Immune Evasion by Regulating PD-L1 Expression through a miR-143/HIF-1a Pathway. Konstantopoulos G, Leventakou D, Saltiel DR, Zervoudi E, Logotheti E, Pettas S, Karagianni K, Daiou A, Hatzistergos KE, Dafou D, Arsenakis M, Psyrri A, Kottaridi C. Viruses. 2024 Jan 12;16(1):113. doi: 10.3390/v16010113. PubMed |
| Functional Analysis of KAP1/TRIM28 Requirements for HIV-1 Transcription Activation. Randolph K, Hyder U, Challa A, Perez E, D'Orso I. Viruses. 2024 Jan 13;16(1):116. doi: 10.3390/v16010116. PubMed |
| Chimeric antigen-receptor (CAR) engineered natural killer cells in a chronic myeloid leukemia (CML) blast crisis model. Imeri J, Marcoux P, Huyghe M, Desterke C, Fantacini DMC, Griscelli F, Covas DT, de Souza LEB, Griscelli AB, Turhan AG. Front Immunol. 2024 Jan 8;14:1309010. doi: 10.3389/fimmu.2023.1309010. eCollection 2023. PubMed |
| Constitutive Endolysosomal Perforation in Neurons allows Induction of alpha-Synuclein Aggregation by Internalized Pre-Formed Fibrils. Sanyal A, Scanavachi G, Somerville E, Saminathan A, Nair A, Oikonomou A, Hatzakis NS, Kirchhausen T. bioRxiv [Preprint]. 2024 Jan 1:2023.12.30.573738. doi: 10.1101/2023.12.30.573738. PubMed |
| Mutations in the non-catalytic polyproline motif destabilize TREX1 and amplify cGAS-STING signaling. Shim A, Luan X, Zhou W, Crow Y, Maciejowski J. bioRxiv [Preprint]. 2024 Jan 4:2024.01.04.574136. doi: 10.1101/2024.01.04.574136. PubMed |
| Direct interrogation of context-dependent GPCR activity with a universal biosensor platform. Janicot R, Maziarz M, Park JC, Luebbers A, Green E, Zhao J, Philibert C, Zhang H, Layne MD, Wu JC, Garcia-Marcos M. bioRxiv [Preprint]. 2024 Jan 2:2024.01.02.573921. doi: 10.1101/2024.01.02.573921. PubMed |
| Charting Single Cell Lineage Dynamics and Mutation Networks via Homing CRISPR. Wang L, Dong W, Yin Z, Sheng J, Ezeana CF, Yang L, Yu X, Wong SS, Wan Z, Danforth RL, Han K, Gao D, Wong STC. bioRxiv [Preprint]. 2024 Jan 7:2024.01.05.574236. doi: 10.1101/2024.01.05.574236. PubMed |
| Germinal Center Cytokines Driven Epigenetic Control of Epstein-Barr Virus Latency Gene Expression. Yifei L, Jinjie Y, Beri NR, Roth LG, Ethel C, Benjamin E G. bioRxiv [Preprint]. 2024 Jan 3:2024.01.02.573986. doi: 10.1101/2024.01.02.573986. PubMed |
| D-type cyclins regulate DNA mismatch repair in the G1 and S phases of the cell cycle, maintaining genome stability. Rona G, Miwatani-Minter B, Zhang Q, Goldberg HV, Kerzhnerman MA, Howard JB, Simoneschi D, Lane E, Hobbs JW, Sassani E, Wang AA, Keegan S, Laverty DJ, Piett CG, Pongor LS, Xu ML, Andrade J, Thomas A, Sicinski P, Askenazi M, Ueberheide B, Fenyo D, Nagel ZD, Pagano M. bioRxiv [Preprint]. 2024 Jan 13:2024.01.12.575420. doi: 10.1101/2024.01.12.575420. PubMed |
| Cytoplasmic accumulation and plasma membrane association of anillin and Ect2 promote confined migration and invasion. Tran AT, Wisniewski EO, Mistriotis P, Stoletov K, Parlani M, Amitrano A, Ifemembi B, Lee SJ, Bera K, Zhang Y, Tuntithavornwat S, Afthinos A, Kiepas A, Jamieson JJ, Zuo Y, Habib D, Wu PH, Martin SS, Gerecht S, Gu L, Lewis JD, Kalab P, Friedl P, Konstantopoulos K. Res Sq [Preprint]. 2024 Jan 10:rs.3.rs-3640969. doi: 10.21203/rs.3.rs-3640969/v1. PubMed |
| RhoA activation promotes glucose uptake to elevate proliferation in MAPK inhibitor resistant melanoma cells. Murali VS, Rajendran D, Isogai T, DeBerardinis RJ, Danuser G. bioRxiv [Preprint]. 2024 Jan 11:2024.01.09.574940. doi: 10.1101/2024.01.09.574940. PubMed |
| A basally active cGAS-STING pathway limits SARS-CoV-2 replication in a subset of ACE2 positive airway cell models. Puray-Chavez M, LaPak KM, Jasuja R, Pan J, Xu J, Eschbach JE, Mohammed S, Lawson DQ, Wang Q, Brody SL, Major MB, Goldfarb D, Kutluay SB. bioRxiv [Preprint]. 2024 Jan 8:2024.01.07.574522. doi: 10.1101/2024.01.07.574522. PubMed |
| Systematic analysis of nonsense variants uncovers peptide release rate as a novel modifier of nonsense-mediated mRNA decay efficiency. Kolakada D, Fu R, Biziaev N, Shuvalov A, Lore M, Campbell AE, Cortazar MA, Sajek MP, Hesselberth JR, Mukherjee N, Alkalaeva E, Jagannathan S. bioRxiv [Preprint]. 2024 Apr 23:2024.01.10.575080. doi: 10.1101/2024.01.10.575080. PubMed |
| Loss of postsynaptic NMDARs drives nanoscale reorganization of Munc13-1 and PSD-95. Dharmasri PA, DeMarco EM, Anderson MC, Levy AD, Blanpied TA. bioRxiv [Preprint]. 2024 Jan 12:2024.01.12.574705. doi: 10.1101/2024.01.12.574705. PubMed |
| Characterizing the secretome of EGFR mutant lung adenocarcinoma. Luu JK, Johnson FD, Jajarmi J, Sihota T, Shi R, Lu D, Farnsworth D, Spencer SE, Negri GL, Morin GB, Lockwood WW. Front Oncol. 2024 Jan 8;13:1286821. doi: 10.3389/fonc.2023.1286821. eCollection 2023. PubMed |
| SLC2A9 rs16890979 reduces uric acid absorption by kidney organoids. Wu S, Li C, Li Y, Liu J, Rong C, Pei H, Li X, Zeng X, Mao W. Front Cell Dev Biol. 2024 Jan 10;11:1268226. doi: 10.3389/fcell.2023.1268226. eCollection 2023. PubMed |
| Epigenetic priming targets tumor heterogeneity to shift transcriptomic phenotype of pancreatic ductal adenocarcinoma towards a Vitamin D susceptible state. He B, Stoffel L, He CJ, Cho K, Li AM, Jiang H, Flowers BM, Nguyen KT, Wang KW, Zhao AY, Zhou MN, Ferreira S, Attardi LD, Ye J. Cell Death Dis. 2024 Jan 26;15(1):89. doi: 10.1038/s41419-024-06460-9. PubMed |
| The P124A mutation of SRP14 alters its migration on SDS-PAGE without impacting its function. Liu Y, Zhou J. Acta Biochim Biophys Sin (Shanghai). 2024 Feb 25;56(2):315-322. doi: 10.3724/abbs.2024004. PubMed |
| Loss of filamentous actin, tight junction protein expression, and paracellular barrier integrity in frataxin-deficient human brain microvascular endothelial cells-implications for blood-brain barrier physiology in Friedreich's ataxia. Smith FM, Kosman DJ. Front Mol Biosci. 2024 Jan 11;10:1299201. doi: 10.3389/fmolb.2023.1299201. eCollection 2023. PubMed |
| Nonsynonymous Mutations in Intellectual Disability and Autism Spectrum Disorder Gene PTCHD1 Disrupt N-Glycosylation and Reduce Protein Stability. Xie CTY, Pastore SF, Vincent JB, Frankland PW, Hamel PA. Cells. 2024 Jan 21;13(2):199. doi: 10.3390/cells13020199. PubMed |
Calcium transients trigger switch-like discharge of prostaglandin E(2) in an extracellular signal-regulated kinase-dependent manner.
Watabe T, Yamahira S, Takakura K, Thumkeo D, Narumiya S, Matsuda M, Terai K.
eLife. 2024 Jan 26;12:RP86727. doi: 10.7554/eLife.86727.
PubMed
Associated Plasmids |
| FBXO38 deficiency promotes lysosome-dependent STING degradation and inhibits cGAS-STING pathway activation. Wu Y, Lin Y, Shen F, Huang R, Zhang Z, Zhou M, Fang Y, Shen J, Fan X. Neoplasia. 2024 Mar;49:100973. doi: 10.1016/j.neo.2024.100973. Epub 2024 Jan 25. PubMed |
| Vascular injury activates the ELK1/SND1/SRF pathway to promote vascular smooth muscle cell proliferative phenotype and neointimal hyperplasia. Su C, Liu M, Yao X, Hao W, Ma J, Ren Y, Gao X, Xin L, Ge L, Yu Y, Wei M, Yang J. Cell Mol Life Sci. 2024 Jan 27;81(1):59. doi: 10.1007/s00018-023-05095-x. PubMed |
| Role of catecholamine synthases in the maintenance of cancer stem-like cells in malignant peripheral nerve sheath tumors. Katayama H, Fujimura A, Huang R, Otani Y, Itano T, Fujiwara T, Kunisada T, Nakata E, Ozaki T. Cancer Sci. 2024 Mar;115(3):871-882. doi: 10.1111/cas.16077. Epub 2024 Jan 26. PubMed |
| ASPM stabilizes the NOTCH intracellular domain 1 and promotes oncogenesis by blocking FBXW7 binding in hepatocellular carcinoma cells. Chan TS, Cheng LH, Hsu CC, Yang PM, Liao TY, Hsieh HY, Lin PC, HuangFu WC, Chuu CP, Tsai KK. Mol Oncol. 2024 Mar;18(3):562-579. doi: 10.1002/1878-0261.13589. Epub 2024 Jan 26. PubMed |
| Novel mechanism of drug resistance triggered by tumor-associated macrophages through Heat Shock Factor-1 activation. Nikotina AD, Vladimirova SA, Kokoreva NE, Nevdakha VA, Lazarev VF, Kuznetcova LS, Komarova EY, Suezov RV, Efremov S, Leonova E, Kartsev VG, Aksenov ND, Margulis BA, Guzhova IV. Cancer Immunol Immunother. 2024 Jan 27;73(2):25. doi: 10.1007/s00262-023-03612-2. PubMed |
| Intracellular trafficking of HIV-1 Gag via Syntaxin 6-positive compartments/vesicles: Involvement in tumor necrosis factor secretion. Tsurutani N, Momose F, Ogawa K, Sano K, Morikawa Y. J Biol Chem. 2024 Mar;300(3):105687. doi: 10.1016/j.jbc.2024.105687. Epub 2024 Jan 26. PubMed |
| Reconstitution of human PDAC using primary cells reveals oncogenic transcriptomic features at tumor onset. Xu Y, Nipper MH, Dominguez AA, Ye Z, Akanuma N, Lopez K, Deng JJ, Arenas D, Sanchez A, Sharkey FE, Court CM, Singhi AD, Wang H, Fernandez-Zapico ME, Sun LZ, Zheng S, Chen Y, Liu J, Wang P. Nat Commun. 2024 Jan 27;15(1):818. doi: 10.1038/s41467-024-45097-2. PubMed |
| Genomic transcription factor binding site selection is edited by the chromatin remodeling factor CHD4. Saotome M, Poduval DB, Grimm SA, Nagornyuk A, Gunarathna S, Shimbo T, Wade PA, Takaku M. Nucleic Acids Res. 2024 Apr 24;52(7):3607-3622. doi: 10.1093/nar/gkae025. PubMed |
| Targeted chemotherapy via HER2-based chimeric antigen receptor (CAR) engineered T-cell membrane coated polymeric nanoparticles. Yaman S, Ramachandramoorthy H, Iyer P, Chintapula U, Nguyen T, Sabnani M, Kotadia T, Ghaffari S, Pop LM, Hannan R, Weidanz JA, Nguyen KT. Bioact Mater. 2024 Jan 11;34:422-435. doi: 10.1016/j.bioactmat.2023.12.027. eCollection 2024 Apr. PubMed |
| Multiscale biophysical analysis of nucleolus disassembly during mitosis. Pham AT, Mani M, Wang X, Vafabakhsh R. Proc Natl Acad Sci U S A. 2024 Feb 6;121(6):e2312250121. doi: 10.1073/pnas.2312250121. Epub 2024 Jan 29. PubMed |
| Loss of Pip4k2c confers liver-metastatic organotropism through insulin-dependent PI3K-AKT pathway activation. Rogava M, Aprati TJ, Chi WY, Melms JC, Hug C, Davis SH, Earlie EM, Chung C, Deshmukh SK, Wu S, Sledge G, Tang S, Ho P, Amin AD, Caprio L, Gurjao C, Tagore S, Ngo B, Lee MJ, Zanetti G, Wang Y, Chen S, Ge W, Melo LMN, Allies G, Rosler J, Gibney GT, Schmitz OJ, Sykes M, Creusot RJ, Tuting T, Schadendorf D, Rocken M, Eigentler TK, Molotkov A, Mintz A, Bakhoum SF, Beyaz S, Cantley LC, Sorger PK, Meckelmann SW, Tasdogan A, Liu D, Laughney AM, Izar B. Nat Cancer. 2024 Mar;5(3):433-447. doi: 10.1038/s43018-023-00704-x. Epub 2024 Jan 29. PubMed |
| The helicase domain of human Dicer prevents RNAi-independent activation of antiviral and inflammatory pathways. Baldaccini M, Gaucherand L, Chane-Woon-Ming B, Messmer M, Gucciardi F, Pfeffer S. EMBO J. 2024 Mar;43(5):806-835. doi: 10.1038/s44318-024-00035-2. Epub 2024 Jan 29. PubMed |
| Genome-wide loss-of-function genetic screen identifies INSIG2 as the vulnerability of hepatitis B virus-integrated hepatoma cells. Fukuoka M, Kodama T, Murai K, Hikita H, Sometani E, Sung J, Shimoda A, Shigeno S, Motooka D, Nishio A, Furuta K, Tatsumi T, Yusa K, Takehara T. Cancer Sci. 2024 Mar;115(3):859-870. doi: 10.1111/cas.16070. Epub 2024 Jan 29. PubMed |
| Immortalization of American miniature horse-derived fibroblast by cell cycle regulator with normal karyotype. Tani T. PeerJ. 2024 Jan 26;12:e16832. doi: 10.7717/peerj.16832. eCollection 2024. PubMed |
| NPAS2 dampens chemo-sensitivity of lung adenocarcinoma cells by enhancing DNA damage repair. Zhang Y, Chen Y, Huang W, Zhou Y, Wang Y, Fu K, Zhuang W. Cell Death Dis. 2024 Jan 30;15(1):101. doi: 10.1038/s41419-023-06256-3. PubMed |
| Genome scale CRISPR screens identify actin capping proteins as key modulators of therapeutic responses to radiation and immunotherapy. Verma N, Renauer PA, Dong C, Xin S, Lin Q, Zhang F, Glazer PM, Chen S. bioRxiv [Preprint]. 2024 Jan 15:2024.01.14.575614. doi: 10.1101/2024.01.14.575614. PubMed |
| Gamma protocadherins in vascular endothelial cells inhibit Klf2/4 to promote atherosclerosis. Joshi D, Coon BG, Chakraborty R, Deng H, Fernandez-Tussy P, Meredith E, Traylor JG Jr, Orr AW, Fernandez-Hernando C, Schwartz MA. bioRxiv [Preprint]. 2024 Jan 21:2024.01.16.575958. doi: 10.1101/2024.01.16.575958. PubMed |
| NRAS Mutant Dictates AHCYL1-Governed ER Calcium Homeostasis for Melanoma Tumor Growth. Cai C, Tu J, Najarro J, Zhang R, Fan H, Zhang FQ, Li J, Xie Z, Su R, Dong L, Arellano N, Ciboddo M, Elf SE, Gao X, Chen J, Wu R. Mol Cancer Res. 2024 Apr 2;22(4):386-401. doi: 10.1158/1541-7786.MCR-23-0445. PubMed |
| CAG repeat expansions create splicing acceptor sites and produce aberrant repeat-containing RNAs. Anderson R, Das MR, Chang Y, Farenhem K, Schmitz CO, Jain A. Mol Cell. 2024 Feb 15;84(4):702-714.e10. doi: 10.1016/j.molcel.2024.01.006. Epub 2024 Jan 30. PubMed |
| Dimethyl alpha-Ketoglutarate Promotes the Synthesis of Collagen and Inhibits Metalloproteinases in HaCaT Cells. Yu BY, Eom DH, Kim HW, Jeong YJ, Keum YS. Biomol Ther (Seoul). 2024 Mar 1;32(2):240-248. doi: 10.4062/biomolther.2023.131. Epub 2024 Feb 1. PubMed |
| HBV promotes its replication by up-regulating RAD51C gene expression. Peng TW, Ma QF, Li J, Wang X, Zhang CH, Ma J, Li JY, Wang W, Zhu CL, Liu XH. Sci Rep. 2024 Jan 31;14(1):2607. doi: 10.1038/s41598-024-53047-7. PubMed |
| An epigenetic barrier sets the timing of human neuronal maturation. Ciceri G, Baggiolini A, Cho HS, Kshirsagar M, Benito-Kwiecinski S, Walsh RM, Aromolaran KA, Gonzalez-Hernandez AJ, Munguba H, Koo SY, Xu N, Sevilla KJ, Goldstein PA, Levitz J, Leslie CS, Koche RP, Studer L. Nature. 2024 Feb;626(8000):881-890. doi: 10.1038/s41586-023-06984-8. Epub 2024 Jan 31. PubMed |
| Liver regulatory mechanisms of noncoding variants at lipid and metabolic trait loci. Pandey GK, Vadlamudi S, Currin KW, Moxley AH, Nicholas JC, McAfee JC, Broadaway KA, Mohlke KL. HGG Adv. 2024 Apr 11;5(2):100275. doi: 10.1016/j.xhgg.2024.100275. Epub 2024 Jan 30. PubMed |
| Integrated analysis and validation reveal CYTH4 as a potential prognostic biomarker in acute myeloid leukemia. Wang H, Xiao Y, Zhou W, Li Y. Oncol Lett. 2024 Jan 16;27(3):103. doi: 10.3892/ol.2024.14236. eCollection 2024 Mar. PubMed |
| The Parkinson's disease related mutant VPS35 (D620N) amplifies the LRRK2 response to endolysosomal stress. McCarron KR, Elcocks H, Mortiboys H, Urbe S, Clague MJ. Biochem J. 2024 Feb 21;481(4):265-278. doi: 10.1042/BCJ20230492. PubMed |
| PNMA2 forms immunogenic non-enveloped virus-like capsids associated with paraneoplastic neurological syndrome. Xu J, Erlendsson S, Singh M, Holling GA, Regier M, Ibiricu I, Einstein J, Hantak MP, Day GS, Piquet AL, Smith TL, Clardy SL, Whiteley AM, Feschotte C, Briggs JAG, Shepherd JD. Cell. 2024 Feb 15;187(4):831-845.e19. doi: 10.1016/j.cell.2024.01.009. Epub 2024 Jan 31. PubMed |
| One-pot DTECT enables rapid and efficient capture of genetic signatures for precision genome editing and clinical diagnostics. Baudrier L, Benamozig O, Langley J, Chopra S, Kalashnikova T, Benaoudia S, Singh G, Mahoney DJ, Wright NAM, Billon P. Cell Rep Methods. 2024 Feb 26;4(2):100698. doi: 10.1016/j.crmeth.2024.100698. Epub 2024 Jan 31. PubMed |
| The chromatin-associated lncREST ensures effective replication stress response by promoting the assembly of fork signaling factors. Statello L, Fernandez-Justel JM, Gonzalez J, Montes M, Ranieri A, Goni E, Mas AM, Huarte M. Nat Commun. 2024 Feb 1;15(1):978. doi: 10.1038/s41467-024-45183-5. PubMed |
| Nuclear to cytoplasmic transport is a druggable dependency in MYC-driven hepatocellular carcinoma. Deutzmann A, Sullivan DK, Dhanasekaran R, Li W, Chen X, Tong L, Mahauad-Fernandez WD, Bell J, Mosley A, Koehler AN, Li Y, Felsher DW. Nat Commun. 2024 Feb 1;15(1):963. doi: 10.1038/s41467-024-45128-y. PubMed |
| METTL16 promotes liver cancer stem cell self-renewal via controlling ribosome biogenesis and mRNA translation. Xue M, Dong L, Zhang H, Li Y, Qiu K, Zhao Z, Gao M, Han L, Chan AKN, Li W, Leung K, Wang K, Pokharel SP, Qing Y, Liu W, Wang X, Ren L, Bi H, Yang L, Shen C, Chen Z, Melstrom L, Li H, Timchenko N, Deng X, Huang W, Rosen ST, Tian J, Xu L, Diao J, Chen CW, Chen J, Shen B, Chen H, Su R. J Hematol Oncol. 2024 Feb 1;17(1):7. doi: 10.1186/s13045-024-01526-9. PubMed |
| Cooperation between PRMT1 and PRMT6 drives lung cancer health disparities among Black/African American men. Wu PY, Van Scoyk M, McHale SS, Chou CF, Riddick G, Farouq K, Hu B, Kraskauskiene V, Koblinski J, Lyons C, Rijal A, Vudatha V, Zhang D, Trevino JG, Shah RD, Nana-Sinkam P, Huang Y, Ma SF, Noth I, Hughes-Halbert C, Seewaldt VL, Chen CY, Winn RA. iScience. 2024 Jan 11;27(2):108858. doi: 10.1016/j.isci.2024.108858. eCollection 2024 Feb 16. PubMed |
| The neuronal transcription factor MEIS2 is a calpain-2 protease target. Muller T, Reichlmeir M, Hau AC, Wittig I, Schulte D. J Cell Sci. 2024 Feb 15;137(4):jcs261482. doi: 10.1242/jcs.261482. Epub 2024 Feb 28. PubMed |
Notch3 directs differentiation of brain mural cells from human pluripotent stem cell-derived neural crest.
Gastfriend BD, Snyder ME, Holt HE, Daneman R, Palecek SP, Shusta EV.
Sci Adv. 2024 Feb 2;10(5):eadi1737. doi: 10.1126/sciadv.adi1737. Epub 2024 Feb 2.
PubMed
Associated Plasmids |
| Discoveries of GPR39 as an evolutionarily conserved receptor for bile acids and of its involvement in biliary acute pancreatitis. Zi Z, Rao Y. Sci Adv. 2024 Feb 2;10(5):eadj0146. doi: 10.1126/sciadv.adj0146. Epub 2024 Feb 2. PubMed |
| 3D bioprinting of human neural tissues with functional connectivity. Yan Y, Li X, Gao Y, Mathivanan S, Kong L, Tao Y, Dong Y, Li X, Bhattacharyya A, Zhao X, Zhang SC. Cell Stem Cell. 2024 Feb 1;31(2):260-274.e7. doi: 10.1016/j.stem.2023.12.009. PubMed |
| Micronucleus is not a potent inducer of the cGAS/STING pathway. Sato Y, Hayashi MT. Life Sci Alliance. 2024 Feb 2;7(4):e202302424. doi: 10.26508/lsa.202302424. Print 2024 Apr. PubMed |
| IkappaBzeta is a dual-use coactivator of NF-kappaB and POU transcription factors. Alpsoy A, Wu XS, Pal S, Klingbeil O, Kumar P, El Demerdash O, Nalbant B, Vakoc CR. Mol Cell. 2024 Mar 21;84(6):1149-1157.e7. doi: 10.1016/j.molcel.2024.01.007. Epub 2024 Feb 2. PubMed |
| Alternative polyadenylation determines the functional landscape of inverted Alu repeats. Ku J, Lee K, Ku D, Kim S, Lee J, Bang H, Kim N, Do H, Lee H, Lim C, Han J, Lee YS, Kim Y. Mol Cell. 2024 Mar 21;84(6):1062-1077.e9. doi: 10.1016/j.molcel.2024.01.008. Epub 2024 Feb 2. PubMed |
| Effect of Octamer-Binding Transcription Factor 4 Overexpression on the Neural Induction of Human Dental Pulp Stem Cells. Gancheva MR, Kremer K, Breen J, Arthur A, Hamilton-Bruce A, Thomas P, Gronthos S, Koblar S. Stem Cell Rev Rep. 2024 Apr;20(3):797-815. doi: 10.1007/s12015-024-10678-7. Epub 2024 Feb 5. PubMed |
| The host RNA polymerase II C-terminal domain is the anchor for replication of the influenza virus genome. Krischuns T, Arragain B, Isel C, Paisant S, Budt M, Wolff T, Cusack S, Naffakh N. Nat Commun. 2024 Feb 5;15(1):1064. doi: 10.1038/s41467-024-45205-2. PubMed |
| A novel class of inhibitors that disrupts the stability of integrin heterodimers identified by CRISPR-tiling-instructed genetic screens. Mattson NM, Chan AKN, Miyashita K, Mukhaleva E, Chang WH, Yang L, Ma N, Wang Y, Pokharel SP, Li M, Liu Q, Xu X, Chen R, Singh P, Zhang L, Elsayed Z, Chen B, Keen D, Pirrotte P, Rosen ST, Chen J, LaBarge MA, Shively JE, Vaidehi N, Rockne RC, Feng M, Chen CW. Nat Struct Mol Biol. 2024 Mar;31(3):465-475. doi: 10.1038/s41594-024-01211-y. Epub 2024 Feb 5. PubMed |
| Sterile inflammation via TRPM8 RNA-dependent TLR3-NF-kB/IRF3 activation promotes antitumor immunity in prostate cancer. Alaimo A, Genovesi S, Annesi N, De Felice D, Subedi S, Macchia A, La Manna F, Ciani Y, Vannuccini F, Mugoni V, Notarangelo M, Libergoli M, Broso F, Taulli R, Ala U, Savino A, Cortese M, Mirzaaghaei S, Poli V, Bonapace IM, Papotti MG, Molinaro L, Doglioni C, Caffo O, Anesi A, Nagler M, Bertalot G, Carbone FG, Barbareschi M, Basso U, Dassi E, Pizzato M, Romanel A, Demichelis F, Kruithof-de Julio M, Lunardi A. EMBO J. 2024 Mar;43(5):780-805. doi: 10.1038/s44318-024-00040-5. Epub 2024 Feb 5. PubMed |
| Genome-wide quantification of copy-number aberration impact on gene expression in ovarian high-grade serous carcinoma. Jamalzadeh S, Dai J, Lavikka K, Li Y, Jiang J, Huhtinen K, Virtanen A, Oikkonen J, Hietanen S, Hynninen J, Vaharautio A, Hakkinen A, Hautaniemi S. BMC Cancer. 2024 Feb 5;24(1):173. doi: 10.1186/s12885-024-11895-6. PubMed |
| SETDB1 promotes progression through upregulation of SF3B4 expression and regulates the immunity in ovarian cancer. Yang H, Sui L, Cai C, Chu H, Diao Y. J Ovarian Res. 2024 Feb 5;17(1):34. doi: 10.1186/s13048-024-01358-8. PubMed |
| Differential histone acetylation and super-enhancer regulation underlie melanoma cell dedifferentiation. Mendelson K, Martin TC, Nguyen CB, Hsu M, Xu J, Lang C, Dummer R, Saenger Y, Messina JL, Sondak VK, Desman G, Hasson D, Bernstein E, Parsons RE, Celebi JT. JCI Insight. 2024 Feb 6;9(6):e166611. doi: 10.1172/jci.insight.166611. PubMed |
| The cyclimids: Degron-inspired cereblon binders for targeted protein degradation. Ichikawa S, Payne NC, Xu W, Chang CF, Vallavoju N, Frome S, Flaxman HA, Mazitschek R, Woo CM. Cell Chem Biol. 2024 Jun 20;31(6):1162-1175.e10. doi: 10.1016/j.chembiol.2024.01.003. Epub 2024 Feb 5. PubMed |
| A clinically applicable connectivity signature for glioblastoma includes the tumor network driver CHI3L1. Hai L, Hoffmann DC, Wagener RJ, Azorin DD, Hausmann D, Xie R, Huppertz MC, Hiblot J, Sievers P, Heuer S, Ito J, Cebulla G, Kourtesakis A, Kaulen LD, Ratliff M, Mandelbaum H, Jung E, Jabali A, Horschitz S, Ernst KJ, Reibold D, Warnken U, Venkataramani V, Will R, Suva ML, Herold-Mende C, Sahm F, Winkler F, Schlesner M, Wick W, Kessler T. Nat Commun. 2024 Feb 6;15(1):968. doi: 10.1038/s41467-024-45067-8. PubMed |
| USP54 is a potential therapeutic target in castration-resistant prostate cancer. Zhou C, Zhang X, Ma H, Zhou Y, Meng Y, Chen C, Shi G, Yu W, Zhang J. BMC Urol. 2024 Feb 6;24(1):32. doi: 10.1186/s12894-024-01418-7. PubMed |
| Integrating leiomyoma genetics, epigenomics, and single-cell transcriptomics reveals causal genetic variants, genes, and cell types. Buyukcelebi K, Duval AJ, Abdula F, Elkafas H, Seker-Polat F, Adli M. Nat Commun. 2024 Feb 7;15(1):1169. doi: 10.1038/s41467-024-45382-0. PubMed |
| Tracing back primed resistance in cancer via sister cells. Dai J, Zheng S, Falco MM, Bao J, Eriksson J, Pikkusaari S, Forsten S, Jiang J, Wang W, Gao L, Perez-Villatoro F, Dufva O, Saeed K, Wang Y, Amiryousefi A, Farkkila A, Mustjoki S, Kauppi L, Tang J, Vaharautio A. Nat Commun. 2024 Feb 7;15(1):1158. doi: 10.1038/s41467-024-45478-7. PubMed |
| A small-molecule degrader selectively inhibits the growth of ALK-rearranged lung cancer with ceritinib resistance. Li X, Wang Z, Chen C, Yang F, Liu P, Fang S, Wang B, Chen S, Li X. iScience. 2024 Jan 26;27(2):109015. doi: 10.1016/j.isci.2024.109015. eCollection 2024 Feb 16. PubMed |
| A microglia clonal inflammatory disorder in Alzheimer's Disease. Vicario R, Fragkogianni S, Weber L, Lazarov T, Hu Y, Hayashi SY, Craddock BP, Socci ND, Alberdi A, Baako A, Ay O, Ogishi M, Lopez-Rodrigo E, Kappagantula R, Viale A, Iacobuzio-Donahue CA, Zhou T, Ransohoff RM, Chesworth R, Bank NB, Abdel-Wahab O, Boisson B, Elemento O, Casanova JL, Miller WT, Geissmann F. bioRxiv [Preprint]. 2024 Jan 25:2024.01.25.577216. doi: 10.1101/2024.01.25.577216. PubMed |
| Human vascular organoids with a mosaic AKT1 mutation recapitulate Proteus syndrome. He S, Zhu Y, Chauhan S, Tavakol DN, Lee JH, Berris RB, Xu C, Lee JH, Lee C, Cai S, McElroy S, Vunjak-Novakovic G, Tomer R, Azizi E, Xu B, Lao YH, Leong KW. bioRxiv [Preprint]. 2024 Jan 27:2024.01.26.577324. doi: 10.1101/2024.01.26.577324. PubMed |
| PREX1 improves homeostatic proliferation to maintain a naive CD4+ T cell compartment in older age. Zhang H, Okuyama H, Jain A, Jadhav RR, Wu B, Sturmlechner I, Morales J, Ohtsuki S, Weyand CM, Goronzy JJ. JCI Insight. 2024 Feb 8;9(5):e172848. doi: 10.1172/jci.insight.172848. PubMed |
| The acidic intrinsically disordered region of the inflammatory mediator HMGB1 mediates fuzzy interactions with CXCL12. Mantonico MV, De Leo F, Quilici G, Colley LS, De Marchis F, Crippa M, Mezzapelle R, Schulte T, Zucchelli C, Pastorello C, Carmeno C, Caprioglio F, Ricagno S, Giachin G, Ghitti M, Bianchi ME, Musco G. Nat Commun. 2024 Feb 8;15(1):1201. doi: 10.1038/s41467-024-45505-7. PubMed |
| Preclinical evaluation of CRISPR-based therapies for Noonan syndrome caused by deep-intronic LZTR1 variants. Knauer C, Haltern H, Schoger E, Kugler S, Roos L, Zelarayan LC, Hasenfuss G, Zimmermann WH, Wollnik B, Cyganek L. Mol Ther Nucleic Acids. 2024 Jan 23;35(1):102123. doi: 10.1016/j.omtn.2024.102123. eCollection 2024 Mar 12. PubMed |
| Development of Chromosome 1q+ Specific Treatment for Highest Risk Pediatric Posterior Fossa Ependymoma. Griesinger AM, Calzadilla AJ, Grimaldo E, Donson AM, Amani V, Pierce AM, Steiner J, Kargar S, Serkova NJ, Bertrand KC, Wright KD, Vibhakar R, Hankinson T, Handler M, Lindsay HB, Foreman NK, Dorris K. Clin Cancer Res. 2024 Apr 15;30(8):1544-1554. doi: 10.1158/1078-0432.CCR-23-3156. PubMed |
| Retrospective identification of cell-intrinsic factors that mark pluripotency potential in rare somatic cells. Jain N, Goyal Y, Dunagin MC, Cote CJ, Mellis IA, Emert B, Jiang CL, Dardani IP, Reffsin S, Arnett M, Yang W, Raj A. Cell Syst. 2024 Feb 21;15(2):109-133.e10. doi: 10.1016/j.cels.2024.01.001. Epub 2024 Feb 8. PubMed |
| Integrative high-throughput enhancer surveying and functional verification divulges a YY2-condensed regulatory axis conferring risk for osteoporosis. Chen XF, Duan YY, Jia YY, Dong QH, Shi W, Zhang Y, Dong SS, Li M, Liu Z, Chen F, Huang XT, Hao RH, Zhu DL, Jing RH, Guo Y, Yang TL. Cell Genom. 2024 Mar 13;4(3):100501. doi: 10.1016/j.xgen.2024.100501. Epub 2024 Feb 8. PubMed |
| Mitochondrial outer membrane integrity regulates a ubiquitin-dependent and NF-kappaB-mediated inflammatory response. Vringer E, Heilig R, Riley JS, Black A, Cloix C, Skalka G, Montes-Gomez AE, Aguado A, Lilla S, Walczak H, Gyrd-Hansen M, Murphy DJ, Huang DT, Zanivan S, Tait SW. EMBO J. 2024 Mar;43(6):904-930. doi: 10.1038/s44318-024-00044-1. Epub 2024 Feb 9. PubMed |
| Involucrasin B Inhibits the Proliferation of Caco-2 Cells by Regulating the TGFbeta/SMAD2-3-4 Pathway. Wang Z, Lin W, Shi M, Hou Y, Liu J, Huang Z, Zhang X, Yang Y, Liu B, Yang Z, Ma W. Molecules. 2024 Feb 1;29(3):686. doi: 10.3390/molecules29030686. PubMed |
| Schwann cell promotes macrophage recruitment through IL-17B/IL-17RB pathway in injured peripheral nerves. Huang Y, Wu L, Zhao Y, Guo J, Li R, Ma S, Ying Z. Cell Rep. 2024 Feb 27;43(2):113753. doi: 10.1016/j.celrep.2024.113753. Epub 2024 Feb 10. PubMed |
| Culture substrate stiffness impacts human myoblast contractility-dependent proliferation and nuclear envelope wrinkling. Nguyen J, Wang L, Lei W, Hu Y, Gulati N, Chavez-Madero C, Ahn H, Ginsberg HJ, Krawetz R, Brandt M, Betz T, Gilbert PM. J Cell Sci. 2024 Mar 15;137(6):jcs261666. doi: 10.1242/jcs.261666. Epub 2024 Mar 27. PubMed |
| A methylation-phosphorylation switch controls EZH2 stability and hematopoiesis. Guo P, Lim RC, Rajawasam K, Trinh T, Sun H, Zhang H. Elife. 2024 Feb 12;13:e86168. doi: 10.7554/eLife.86168. PubMed |
| NSD1 supports cell growth and regulates autophagy in HPV-negative head and neck squamous cell carcinoma. Topchu I, Bychkov I, Gursel D, Makhov P, Boumber Y. Cell Death Discov. 2024 Feb 13;10(1):75. doi: 10.1038/s41420-024-01842-6. PubMed |
| Exploiting epigenetic targets to overcome taxane resistance in prostate cancer. Cevatemre B, Bulut I, Dedeoglu B, Isiklar A, Syed H, Bayram OY, Bagci-Onder T, Acilan C. Cell Death Dis. 2024 Feb 12;15(2):132. doi: 10.1038/s41419-024-06422-1. PubMed |
| NS1-mediated enhancement of MVC transcription and replication promoted by KAT5/H4K12ac. Zhang X, Guo J, Xu H, Ding S, Liu L, Chen Z, Yang J, Liu Y, Hao H, Huang F, Qiu J, Guan W, Sun Y, Liu H. J Virol. 2024 Mar 19;98(3):e0169523. doi: 10.1128/jvi.01695-23. Epub 2024 Feb 13. PubMed |
| Discovery and characterization of anti-cancer peptides from a random peptide library. Puvvula PK, Moon AM. PLoS One. 2024 Feb 13;19(2):e0293072. doi: 10.1371/journal.pone.0293072. eCollection 2024. PubMed |
| Programmable RNA writing with trans-splicing. Schmitt-Ulms C, Kayabolen A, Manero-Carranza M, Zhou N, Donnelly K, Nuccio SP, Kato K, Nishimasu H, Gootenberg JS, Abudayyeh OO. bioRxiv [Preprint]. 2024 Feb 1:2024.01.31.578223. doi: 10.1101/2024.01.31.578223. PubMed |
| Kinome-Wide Synthetic Lethal Screen Identifies PANK4 as a Modulator of Temozolomide Resistance in Glioblastoma. Vella V, Ditsiou A, Chalari A, Eravci M, Wooller SK, Gagliano T, Bani C, Kerschbamer E, Karakostas C, Xu B, Zhang Y, Pearl FMG, Lopez G, Peng L, Stebbing J, Klinakis A, Giamas G. Adv Sci (Weinh). 2024 Apr;11(15):e2306027. doi: 10.1002/advs.202306027. Epub 2024 Feb 14. PubMed |
| Local monomer levels and established filaments potentiate non-muscle myosin 2 assembly. Quintanilla MA, Patel H, Wu H, Sochacki KA, Chandrasekar S, Akamatsu M, Rotty JD, Korobova F, Bear JE, Taraska JW, Oakes PW, Beach JR. J Cell Biol. 2024 Apr 1;223(4):e202305023. doi: 10.1083/jcb.202305023. Epub 2024 Feb 14. PubMed |
| SP3-induced Timeless transcription contributes to cell growth of lung adenocarcinoma cells. Tian P, Du D, Yang L, Zhou N, Tao L. PLoS One. 2024 Feb 14;19(2):e0298295. doi: 10.1371/journal.pone.0298295. eCollection 2024. PubMed |
Uncovering receptor-ligand interactions using a high-avidity CRISPR activation screening platform.
Yang L, Sheets TP, Feng Y, Yu G, Bajgain P, Hsu KS, So D, Seaman S, Lee J, Lin L, Evans CN, Guest MR, Chari R, St Croix B.
Sci Adv. 2024 Feb 16;10(7):eadj2445. doi: 10.1126/sciadv.adj2445. Epub 2024 Feb 14.
PubMed
Associated Plasmids |
| Epigenetic regulation of CD38/CD48 by KDM6A mediates NK cell response in multiple myeloma. Liu J, Xing L, Li J, Wen K, Liu N, Liu Y, Wu G, Wang S, Ogiya D, Song TY, Kurata K, Penailillo J, Morelli E, Wang T, Hong X, Gulla A, Tai YT, Munshi N, Richardson P, Carrasco R, Hideshima T, Anderson KC. Nat Commun. 2024 Feb 14;15(1):1367. doi: 10.1038/s41467-024-45561-z. PubMed |
| Genetic determinants of micronucleus formation in vivo. Adams DJ, Barlas B, McIntyre RE, Salguero I, van der Weyden L, Barros A, Vicente JR, Karimpour N, Haider A, Ranzani M, Turner G, Thompson NA, Harle V, Olvera-Leon R, Robles-Espinoza CD, Speak AO, Geisler N, Weninger WJ, Geyer SH, Hewinson J, Karp NA, Fu B, Yang F, Kozik Z, Choudhary J, Yu L, van Ruiten MS, Rowland BD, Lelliott CJ, Del Castillo Velasco-Herrera M, Verstraten R, Bruckner L, Henssen AG, Rooimans MA, de Lange J, Mohun TJ, Arends MJ, Kentistou KA, Coelho PA, Zhao Y, Zecchini H, Perry JRB, Jackson SP, Balmus G. Nature. 2024 Mar;627(8002):130-136. doi: 10.1038/s41586-023-07009-0. Epub 2024 Feb 14. PubMed |
| Targeted inhibition of SCF(SKP2) confers anti-tumor activities resulting in a survival benefit in osteosarcoma. Wang J, Ferrena A, Zhang R, Singh S, Viscarret V, Al-Harden W, Aldahamsheh O, Borjihan H, Singla A, Yaguare S, Tingling J, Zi X, Lo Y, Gorlick R, Schwartz EL, Zhao H, Yang R, Geller DS, Zheng D, Hoang BH. Oncogene. 2024 Mar;43(13):962-975. doi: 10.1038/s41388-024-02942-4. Epub 2024 Feb 14. PubMed |
| Mesothelin Secretion by Pancreatic Cancer Cells Co-opts Macrophages and Promotes Metastasis. Luckett T, Abudula M, Ireland L, Glenn M, Bellomo G, Stafferton R, Halloran C, Ghaneh P, Jones R, Schmid MC, Mielgo A. Cancer Res. 2024 Feb 15;84(4):527-544. doi: 10.1158/0008-5472.CAN-23-1542. PubMed |
| The phosphatidylinositol-5' phosphatase synaptojanin1 limits integrin-mediated invasion of Staphylococcus aureus. Shi Y, Muenzner P, Schanz-Jurinka S, Hauck CR. Microbiol Spectr. 2024 Apr 2;12(4):e0200623. doi: 10.1128/spectrum.02006-23. Epub 2024 Feb 15. PubMed |
| VPS13C regulates phospho-Rab10-mediated lysosomal function in human dopaminergic neurons. Schrӧder LF, Peng W, Gao G, Wong YC, Schwake M, Krainc D. J Cell Biol. 2024 May 6;223(5):e202304042. doi: 10.1083/jcb.202304042. Epub 2024 Feb 15. PubMed |
| Clinical, immunohistochemical, and genetic characterization of splice-altering biallelic DES variants: Therapeutic implications. Geist Hauserman J, Laverty CG, Donkervoort S, Hu Y, Silverstein S, Neuhaus SB, Saade D, Vaughn G, Malicki D, Kaur R, Li Y, Luo Y, Liu P, Burr P, Foley AR, Mohassel P, Bonnemann CG. HGG Adv. 2024 Apr 11;5(2):100274. doi: 10.1016/j.xhgg.2024.100274. Epub 2024 Feb 2. PubMed |
| Experimental evidence for cancer resistance in a bat species. Hua R, Ma YS, Yang L, Hao JJ, Hua QY, Shi LY, Yao XQ, Zhi HY, Liu Z. Nat Commun. 2024 Feb 15;15(1):1401. doi: 10.1038/s41467-024-45767-1. PubMed |
| Shared and distinct mechanisms of UBA1 inactivation across different diseases. Collins JC, Magaziner SJ, English M, Hassan B, Chen X, Balanda N, Anderson M, Lam A, Fernandez-Pol S, Kwong B, Greenberg PL, Terrier B, Likhite ME, Kosmider O, Wang Y, Samara NL, Walters KJ, Beck DB, Werner A. EMBO J. 2024 May;43(10):1919-1946. doi: 10.1038/s44318-024-00046-z. Epub 2024 Feb 15. PubMed |
| Induction of stearoyl-CoA desaturase confers cell density-dependent ferroptosis resistance in melanoma. Shirahama H, Tani Y, Tsukahara S, Okamoto Y, Hasebe A, Noda T, Ando S, Ushijima M, Matsuura M, Tomida A. J Cell Biochem. 2024 Apr;125(4):e30542. doi: 10.1002/jcb.30542. Epub 2024 Feb 16. PubMed |
| Tsyn-Seq: a T-cell Synapse-Based Antigen Identification Platform. Jin Y, Miyama T, Brown A, Hayase T, Song X, Singh AK, Huang L, Flores II, McDaniel LK, Glover I, Halsey TM, Prasad R, Chapa V, Ahmed S, Zhang J, Rai K, Peterson CB, Lizee G, Karmouch J, Hayase E, Molldrem JJ, Chang CC, Tsai WB, Jenq RR. Cancer Immunol Res. 2024 May 2;12(5):530-543. doi: 10.1158/2326-6066.CIR-23-0467. PubMed |
| A regulatory element associated to NAFLD in the promoter of DIO1 controls LDL-C, HDL-C and triglycerides in hepatic cells. Castillejo-Lopez C, Barcenas-Walls JR, Cavalli M, Larsson A, Wadelius C. Lipids Health Dis. 2024 Feb 16;23(1):48. doi: 10.1186/s12944-024-02029-9. PubMed |
| PAF1c links S-phase progression to immune evasion and MYC function in pancreatic carcinoma. Gaballa A, Gebhardt-Wolf A, Krenz B, Mattavelli G, John M, Cossa G, Andreani S, Schulein-Volk C, Montesinos F, Vidal R, Kastner C, Ade CP, Kneitz B, Gasteiger G, Gallant P, Rosenfeldt M, Riedel A, Eilers M. Nat Commun. 2024 Feb 16;15(1):1446. doi: 10.1038/s41467-024-45760-8. PubMed |
| Characterization of enhancer activity in early human neurodevelopment using Massively Parallel Reporter Assay (MPRA) and forebrain organoids. Capauto D, Wang Y, Wu F, Norton S, Mariani J, Inoue F, Crawford GE, Ahituv N, Abyzov A, Vaccarino FM. Sci Rep. 2024 Feb 16;14(1):3936. doi: 10.1038/s41598-024-54302-7. PubMed |
| Tropomyosin1 isoforms underlie epithelial to mesenchymal plasticity, metastatic dissemination, and resistance to chemotherapy in high-grade serous ovarian cancer. Xu T, Verhagen MP, Teeuwssen M, Sun W, Joosten R, Sacchetti A, Ewing-Graham PC, Jansen MPHM, Boere IA, Bryce NS, Zeng J, Treutlein HR, Hook J, Hardeman EC, Gunning PW, Fodde R. Cell Death Differ. 2024 Mar;31(3):360-377. doi: 10.1038/s41418-024-01267-9. Epub 2024 Feb 16. PubMed |
| Pan-cancer Genomic Analysis of AXL Mutations Reveals a Novel, Recurrent, Functionally Activating AXL W451C Alteration Specific to Myxofibrosarcoma. Williams EA, Vegas I, El-Senduny FF, Zhang J, Mata DA, Hiemenz MC, Hughes SR, Sa BC, Kraft GP, Gorbatov N, Foley-Peres K, Sanchez EZ, Milikowski C, Williams KJ, Ross JS, Kurzrock R, Montgomery EA, Lombard DB, Kumar S. Am J Surg Pathol. 2024 Jun 1;48(6):699-707. doi: 10.1097/PAS.0000000000002191. Epub 2024 Feb 19. PubMed |
| Sparse CBX2 nucleates many Polycomb proteins to promote facultative heterochromatinization of Polycomb target genes. Ingersoll S, Trouth A, Luo X, Espinoza A, Wen J, Tucker J, Astatike K, Phiel CJ, Kutateladze TG, Wu TP, Ramachandran S, Ren X. bioRxiv [Preprint]. 2024 Feb 5:2024.02.05.578969. doi: 10.1101/2024.02.05.578969. PubMed |
| Persistent tailoring of MSC activation through genetic priming. Beauregard MA, Bedford GC, Brenner DA, Sanchez Solis LD, Nishiguchi T, Abhimanyu, Longlax SC, Mahata B, Veiseh O, Wenzel PL, DiNardo AR, Hilton IB, Diehl MR. bioRxiv [Preprint]. 2024 Feb 7:2024.02.01.578489. doi: 10.1101/2024.02.01.578489. PubMed |
| Epigenomic analyses identify FOXM1 as a key regulator of anti-tumor immune response in esophageal adenocarcinoma. Ziman B, Yang Q, Zheng Y, Sheth M, Nam C, Zhao H, Zhang L, Hu B, Bhowmick NA, Sinha UK, Lin DC. Cell Death Dis. 2024 Feb 19;15(2):152. doi: 10.1038/s41419-024-06488-x. PubMed |
| PKCmu promotes keratinocyte cell migration through Cx43 phosphorylation-mediated suppression of intercellular communication. Pun R, Cavanaugh AM, Aldrich E, Tran O, Rudd JC, Hansen LA, North BJ. iScience. 2024 Jan 29;27(3):109033. doi: 10.1016/j.isci.2024.109033. eCollection 2024 Mar 15. PubMed |
| Host E3 ubiquitin ligase ITCH mediates Toxoplasma gondii effector GRA35-triggered NLRP1 inflammasome activation and cell-autonomous immunity. Wang Y, Hollingsworth LR, Sangare LO, Paredes-Santos TC, Krishnamurthy S, Penn BH, Wu H, Saeij JPJ. mBio. 2024 Mar 13;15(3):e0330223. doi: 10.1128/mbio.03302-23. Epub 2024 Feb 20. PubMed |
| The NP protein of Newcastle disease virus dictates its oncolytic activity by regulating viral mRNA translation efficiency. Liao T, Chen Y, Guo L, Zhu S, Zhan T, Lu X, Xu H, Hu Z, Hu J, Gu M, Liu X, Wang X, Hu S, Liu X. PLoS Pathog. 2024 Feb 20;20(2):e1012027. doi: 10.1371/journal.ppat.1012027. eCollection 2024 Feb. PubMed |
| Resistance of HNSCC cell models to pan-FGFR inhibition depends on the EMT phenotype associating with clinical outcome. Broghammer F, Korovina I, Gouda M, Celotti M, van Es J, Lange I, Brunner C, Mircetic J, Coppes RP, Gires O, Dahl A, Seifert M, Cordes N. Mol Cancer. 2024 Feb 21;23(1):39. doi: 10.1186/s12943-024-01954-8. PubMed |
| Plasticity-induced repression of Irf6 underlies acquired resistance to cancer immunotherapy in pancreatic ductal adenocarcinoma. Kim IK, Diamond MS, Yuan S, Kemp SB, Kahn BM, Li Q, Lin JH, Li J, Norgard RJ, Thomas SK, Merolle M, Katsuda T, Tobias JW, Baslan T, Politi K, Vonderheide RH, Stanger BZ. Nat Commun. 2024 Feb 20;15(1):1532. doi: 10.1038/s41467-024-46048-7. PubMed |
| Chronic endoplasmic reticulum stress in myotonic dystrophy type 2 promotes autoimmunity via mitochondrial DNA release. Rosing S, Ullrich F, Meisterfeld S, Schmidt F, Mlitzko L, Croon M, Nattrass RG, Eberl N, Mahlberg J, Schlee M, Wieland A, Simon P, Hilbig D, Reuner U, Rapp A, Bremser J, Mirtschink P, Drukewitz S, Zillinger T, Beissert S, Paeschke K, Hartmann G, Trifunovic A, Bartok E, Gunther C. Nat Commun. 2024 Feb 20;15(1):1534. doi: 10.1038/s41467-024-45535-1. PubMed |
| Downregulation of praja2 restrains endocytosis and boosts tyrosine kinase receptors in kidney cancer. Rinaldi L, Chiuso F, Senatore E, Borzacchiello D, Lignitto L, Iannucci R, Donne RD, Fuggi M, Reale C, Russo F, Russo NA, Giurato G, Rizzo F, Sellitto A, Santangelo M, De Biase D, Paciello O, D'Ambrosio C, Amente S, Garbi C, Dalla E, Scaloni A, Weisz A, Ambrosino C, Insabato L, Feliciello A. Commun Biol. 2024 Feb 20;7(1):208. doi: 10.1038/s42003-024-05823-4. PubMed |
| The role of microRNA-325-3p as a critical player in cell death in NSCs and astrocytes. Lee Y, Lee SW, Jeong D, Lee HJ, Ko K. Front Cell Dev Biol. 2024 Jan 16;11:1223987. doi: 10.3389/fcell.2023.1223987. eCollection 2023. PubMed |
| Serotonin Receptor HTR2B Facilitates Colorectal Cancer Metastasis via CREB1-ZEB1 Axis-Mediated Epithelial-Mesenchymal Transition. Li T, Wei L, Zhang X, Fu B, Zhou Y, Yang M, Cao M, Chen Y, Tan Y, Shi Y, Wu L, Xuan C, Du Q, Hu R. Mol Cancer Res. 2024 Jun 4;22(6):538-554. doi: 10.1158/1541-7786.MCR-23-0513. PubMed |
| Selective CDK7 Inhibition Suppresses Cell Cycle Progression and MYC Signaling While Enhancing Apoptosis in Therapy-resistant Estrogen Receptor-positive Breast Cancer. Guarducci C, Nardone A, Russo D, Nagy Z, Heraud C, Grinshpun A, Zhang Q, Freelander A, Leventhal MJ, Feit A, Cohen Feit G, Feiglin A, Liu W, Hermida-Prado F, Kesten N, Ma W, De Angelis C, Morlando A, O'Donnell M, Naumenko S, Huang S, Nguyen QD, Huang Y, Malorni L, Bergholz JS, Zhao JJ, Fraenkel E, Lim E, Schiff R, Shapiro GI, Jeselsohn R. Clin Cancer Res. 2024 May 1;30(9):1889-1905. doi: 10.1158/1078-0432.CCR-23-2975. PubMed |
| SRRM2 phase separation drives assembly of nuclear speckle subcompartments. Zhang M, Gu Z, Guo S, Sun Y, Ma S, Yang S, Guo J, Fang C, Shu L, Ge Y, Chen Z, Wang B. Cell Rep. 2024 Mar 26;43(3):113827. doi: 10.1016/j.celrep.2024.113827. Epub 2024 Feb 20. PubMed |
| Cullin-RING ligases employ geometrically optimized catalytic partners for substrate targeting. Li J, Purser N, Liwocha J, Scott DC, Byers HA, Steigenberger B, Hill S, Tripathi-Giesgen I, Hinkle T, Hansen FM, Prabu JR, Radhakrishnan SK, Kirkpatrick DS, Reichermeier KM, Schulman BA, Kleiger G. Mol Cell. 2024 Apr 4;84(7):1304-1320.e16. doi: 10.1016/j.molcel.2024.01.022. Epub 2024 Feb 20. PubMed |
| Thalamocortical organoids enable in vitro modeling of 22q11.2 microdeletion associated with neuropsychiatric disorders. Shin D, Kim CN, Ross J, Hennick KM, Wu SR, Paranjape N, Leonard R, Wang JC, Keefe MG, Pavlovic BJ, Donohue KC, Moreau C, Wigdor EM, Larson HH, Allen DE, Cadwell CR, Bhaduri A, Popova G, Bearden CE, Pollen AA, Jacquemont S, Sanders SJ, Haussler D, Wiita AP, Frost NA, Sohal VS, Nowakowski TJ. Cell Stem Cell. 2024 Mar 7;31(3):421-432.e8. doi: 10.1016/j.stem.2024.01.010. Epub 2024 Feb 20. PubMed |
| Host ZCCHC3 blocks HIV-1 infection and production through a dual mechanism. Yi B, Tanaka YL, Cornish D, Kosako H, Butlertanaka EP, Sengupta P, Lippincott-Schwartz J, Hultquist JF, Saito A, Yoshimura SH. iScience. 2024 Feb 5;27(3):109107. doi: 10.1016/j.isci.2024.109107. eCollection 2024 Mar 15. PubMed |
A versatile CRISPR-Cas13d platform for multiplexed transcriptomic regulation and metabolic engineering in primary human T cells.
Tieu V, Sotillo E, Bjelajac JR, Chen C, Malipatlolla M, Guerrero JA, Xu P, Quinn PJ, Fisher C, Klysz D, Mackall CL, Qi LS.
Cell. 2024 Feb 29;187(5):1278-1295.e20. doi: 10.1016/j.cell.2024.01.035. Epub 2024 Feb 21.
PubMed
Associated Plasmids |
| CD73 mitigates ZEB1 expression in papillary thyroid carcinoma. Vedovatto S, Oliveira FD, Pereira LC, Scheffel TB, Beckenkamp LR, Bertoni APS, Wink MR, Lenz G. Cell Commun Signal. 2024 Feb 22;22(1):145. doi: 10.1186/s12964-024-01522-z. PubMed |
| Prolonged overexpression of PLK4 leads to formation of centriole rosette clusters that are connected via canonical centrosome linker proteins. Ozcan SC, Kalkan BM, Cicek E, Canbaz AA, Acilan C. Sci Rep. 2024 Feb 22;14(1):4370. doi: 10.1038/s41598-024-53985-2. PubMed |
| Modeling the precise interaction of glioblastoma with human brain region-specific organoids. Fan Q, Wang H, Gu T, Liu H, Deng P, Li B, Yang H, Mao Y, Shao Z. iScience. 2024 Feb 5;27(3):109111. doi: 10.1016/j.isci.2024.109111. eCollection 2024 Mar 15. PubMed |
| Effect of hypoxia‑HIF‑1alpha‑periostin axis in thyroid cancer. Yang Y, Wu J, Zhu H, Shi X, Liu J, Li Y, Wang M. Oncol Rep. 2024 Apr;51(4):57. doi: 10.3892/or.2024.8716. Epub 2024 Feb 23. PubMed |
| Modulation of Type 5 Metabotropic Glutamate Receptor-Mediated Intracellular Calcium Mobilization by Regulator of G Protein Signaling 4 (RGS4) in Cultured Astrocytes. Beckers P, Doyen PJ, Hermans E. Cells. 2024 Feb 6;13(4):291. doi: 10.3390/cells13040291. PubMed |
| Development of Virus-like Particle Plant-Based Vaccines against Avian H5 and H9 Influenza A Viruses. Elbohy OA, Iqbal M, Daly JM, Dunham SP. Vet Sci. 2024 Feb 18;11(2):93. doi: 10.3390/vetsci11020093. PubMed |
| Therapeutic targeting Tudor domains in leukemia via CRISPR-Scan Assisted Drug Discovery. Chan AKN, Han L, Delaney CD, Wang X, Mukhaleva E, Li M, Yang L, Pokharel SP, Mattson N, Garcia M, Wang B, Xu X, Zhang L, Singh P, Elsayed Z, Chen R, Kuang B, Wang J, Yuan YC, Chen B, Chan LN, Rosen ST, Horne D, Muschen M, Chen J, Vaidehi N, Armstrong SA, Su R, Chen CW. Sci Adv. 2024 Feb 23;10(8):eadk3127. doi: 10.1126/sciadv.adk3127. Epub 2024 Feb 23. PubMed |
| Restoration of miR-299-3p promotes macrophage phagocytosis and suppresses malignant phenotypes in breast cancer carcinogenesis via dual-targeting CD47 and ABCE1. Tong S, Zhu Y, Leng Y, Wu Y, Xiao X, Zhao W, Tan S. Int Immunopharmacol. 2024 Mar 30;130:111708. doi: 10.1016/j.intimp.2024.111708. Epub 2024 Feb 22. PubMed |
| Super-sectioning with multi-sheet reversible saturable optical fluorescence transitions (RESOLFT) microscopy. Boden A, Ollech D, York AG, Millett-Sikking A, Testa I. Nat Methods. 2024 May;21(5):882-888. doi: 10.1038/s41592-024-02196-8. Epub 2024 Feb 23. PubMed |
| Quantitative MRI Evaluation of Ferritin Overexpression in Non-Small-Cell Lung Cancer. Singhania M, Zaher A, Pulliam CF, Bayanbold K, Searby CC, Schoenfeld JD, Mapuskar KA, Fath MA, Allen BG, Spitz DR, Petronek MS. Int J Mol Sci. 2024 Feb 18;25(4):2398. doi: 10.3390/ijms25042398. PubMed |
| Epigenetic Targeting to Overcome Radioresistance in Head and Neck Cancer. Schniewind I, Besso MJ, Klicker S, Schwarz FM, Hadiwikarta WW, Richter S, Lock S, Linge A, Krause M, Dubrovska A, Baumann M, Kurth I, Peitzsch C. Cancers (Basel). 2024 Feb 9;16(4):730. doi: 10.3390/cancers16040730. PubMed |
| ANLN Promotes the Proliferation and Migration of Gallbladder Cancer Cells via STRA6-Mediated Activation of PI3K/AKT Signaling. Zhu X, Zhang Y, Bian R, Zhu J, Shi W, Ye Y. Cancers (Basel). 2024 Feb 11;16(4):752. doi: 10.3390/cancers16040752. PubMed |
| Transduction Efficiency of Zika Virus E Protein Pseudotyped HIV-1gfp and Its Oncolytic Activity Tested in Primary Glioblastoma Cell Cultures. Formanski JP, Ngo HD, Grunwald V, Pohlking C, Jonas JS, Wohlers D, Schwalbe B, Schreiber M. Cancers (Basel). 2024 Feb 17;16(4):814. doi: 10.3390/cancers16040814. PubMed |
| The Nitro Group Reshapes the Effects of Pyrido[3,4-g]quinazoline Derivatives on DYRK/CLK Activity and RNA Splicing in Glioblastoma Cells. Borisevich SS, Aksinina TE, Ilyina MG, Shender VO, Anufrieva KS, Arapidi GP, Antipova NV, Anizon F, Esvan YJ, Giraud F, Tatarskiy VV, Moreau P, Shakhparonov MI, Pavlyukov MS, Shtil AA. Cancers (Basel). 2024 Feb 19;16(4):834. doi: 10.3390/cancers16040834. PubMed |
| Optimized protocol for CRISPR knockout of human iPSC-derived macrophages. Navarro-Guerrero E, Baronio R, Tay C, Knight JC, Ebner DV. STAR Protoc. 2024 Mar 15;5(1):102903. doi: 10.1016/j.xpro.2024.102903. Epub 2024 Feb 23. PubMed |
| Polypyrimidine tract-binding protein 3/insulin-like growth factor 2 mRNA-binding proteins 3/high-mobility group A1 axis promotes renal cancer growth and metastasis. Wang Q, Chen F, He Y, Gao Y, Wang J, Chu S, Xie P, Zhong J, Shan H, Bai J, Hou P. iScience. 2024 Feb 9;27(3):109158. doi: 10.1016/j.isci.2024.109158. eCollection 2024 Mar 15. PubMed |
| Pseudotyped virus infection of multiplexed ACE2 libraries reveals SARS-CoV-2 variant shifts in receptor usage. Shukla N, Roelle SM, Snell JC, DelSignore O, Bruchez AM, Matreyek KA. bioRxiv [Preprint]. 2024 Feb 14:2024.02.13.580056. doi: 10.1101/2024.02.13.580056. PubMed |
| Scalable and Efficient Generation of Mouse Primordial Germ Cell-like Cells. Ding X, Li L, Gao J, Yi D, Schimenti JC. bioRxiv [Preprint]. 2024 Feb 15:2024.02.15.580543. doi: 10.1101/2024.02.15.580543. PubMed |
| KDM6A Regulates Immune Response Genes in Multiple Myeloma. Dupere-Richer D, Riva A, Maji S, Barwick BG, Roman HC, Sobh A, Quickstad G, Li J, De U, Piper C, Kulis M, Ezponda T, Martin-Subero JI, Tonon G, Zhang W, Mitsiades CS, Boise LH, Bennett RL, Licht JD. bioRxiv [Preprint]. 2024 Feb 12:2024.02.12.579179. doi: 10.1101/2024.02.12.579179. PubMed |
| Translational response to mitochondrial stresses is orchestrated by tRNA modifications. Rashad S, Al-Mesitef S, Mousa A, Zhou Y, Ando D, Sun G, Fukuuchi T, Iwasaki Y, Xiang J, Byrne SR, Sun J, Maekawa M, Saigusa D, Begley TJ, Dedon PC, Niizuma K. bioRxiv [Preprint]. 2024 Feb 14:2024.02.14.580389. doi: 10.1101/2024.02.14.580389. PubMed |
| Targeting autophagy overcomes cancer-intrinsic resistance to CAR-T immunotherapy in B-cell malignancies. Tang L, Zhang H, Zhou F, Wei Q, Du M, Wu J, Li C, Luo W, Zhou J, Wang X, Chen Z, Zhang Y, Huang Z, Wu Z, Wen Y, Jiang H, Liao D, Kou H, Xiong W, Mei H, Hu Y. Cancer Commun (Lond). 2024 Mar;44(3):408-432. doi: 10.1002/cac2.12525. Epub 2024 Feb 26. PubMed |
| ACKR3 Proximity Labeling Identifies Novel G protein- and beta-arrestin-independent GPCR Interacting Proteins. Hicks C, Gardner J, Eiger DS, Camarda ND, Pham U, Dhar S, Rodriguez H, Chundi A, Rajagopal S. bioRxiv [Preprint]. 2024 Jan 28:2024.01.27.577545. doi: 10.1101/2024.01.27.577545. PubMed |
Framework for in vivo T cell screens.
Milling LE, Markson SC, Tjokrosurjo Q, Derosia NM, Streeter ISL, Hickok GH, Lemmen AM, Nguyen TH, Prathima P, Fithian W, Schwartz MA, Hacohen N, Doench JG, LaFleur MW, Sharpe AH.
J Exp Med. 2024 Apr 1;221(4):e20230699. doi: 10.1084/jem.20230699. Epub 2024 Feb 27.
PubMed
Associated Plasmids |
Direct interrogation of context-dependent GPCR activity with a universal biosensor platform.
Janicot R, Maziarz M, Park JC, Zhao J, Luebbers A, Green E, Philibert CE, Zhang H, Layne MD, Wu JC, Garcia-Marcos M.
Cell. 2024 Feb 16:S0092-8674(24)00065-5. doi: 10.1016/j.cell.2024.01.028.
PubMed
Associated Plasmids |
| AF1q is a universal marker of neuroblastoma that sustains N-Myc expression and drives tumorigenesis. Oskouian B, Lee JY, Asgharzadeh S, Khan R, Zhang M, Weisbrod JR, Choi YJ, Puri L, Aguilar AE, Zhao P, Saba JD. Oncogene. 2024 Apr;43(16):1203-1213. doi: 10.1038/s41388-024-02980-y. Epub 2024 Feb 27. PubMed |
| Quantifying Fluorescence Lifetime Responsiveness of Environment-Sensitive Probes for Membrane Fluidity Measurements. Ragaller F, Sjule E, Urem YB, Schlegel J, El R, Urbancic D, Urbancic I, Blom H, Sezgin E. J Phys Chem B. 2024 Mar 7;128(9):2154-2167. doi: 10.1021/acs.jpcb.3c07006. Epub 2024 Feb 28. PubMed |
| NOVA1 acts as an oncogenic RNA-binding protein to regulate cholesterol homeostasis in human glioblastoma cells. Saito Y, Yang Y, Saito M, Park CY, Funato K, Tabar V, Darnell RB. Proc Natl Acad Sci U S A. 2024 Mar 5;121(10):e2314695121. doi: 10.1073/pnas.2314695121. Epub 2024 Feb 28. PubMed |
| Bile Acid Metabolism Mediates Cholesterol Homeostasis and Promotes Tumorigenesis in Clear Cell Renal Cell Carcinoma. Riscal R, Gardner SM, Coffey NJ, Carens M, Mesaros C, Xu JP, Xue Y, Davis L, Demczyszyn S, Vogt A, Olia A, Finan JM, Godfrey J, Schultz DC, Blair IA, Keith B, Marmorstein R, Skuli N, Simon MC. Cancer Res. 2024 May 15;84(10):1570-1582. doi: 10.1158/0008-5472.CAN-23-0821. PubMed |
| Hypoxia-induced immortalization of primary cells depends on Tfcp2L1 expression. Otero-Albiol D, Santos-Pereira JM, Lucena-Cacace A, Clemente-Gonzalez C, Munoz-Galvan S, Yoshida Y, Carnero A. Cell Death Dis. 2024 Feb 28;15(2):177. doi: 10.1038/s41419-024-06567-z. PubMed |
| Integration of transcription regulation and functional genomic data reveals lncRNA SNHG6's role in hematopoietic differentiation and leukemia. Hazan JM, Amador R, Ali-Nasser T, Lahav T, Shotan SR, Steinberg M, Cohen Z, Aran D, Meiri D, Assaraf YG, Guigo R, Bester AC. J Biomed Sci. 2024 Feb 28;31(1):27. doi: 10.1186/s12929-024-01015-8. PubMed |
| PB2 residue 473 contributes to the mammalian virulence of H7N9 avian influenza virus by modulating viral polymerase activity via ANP32A. Zhang M, Liu M, Chen H, Qiu T, Jin X, Fu W, Teng Q, Zhao C, Xu J, Li Z, Zhang X. J Virol. 2024 Mar 19;98(3):e0194423. doi: 10.1128/jvi.01944-23. Epub 2024 Feb 29. PubMed |
| The SARS-CoV-2 Spike is a virulence determinant and plays a major role on the attenuated phenotype of Omicron virus in a feline model of infection. Martins M, Nooruzzaman M, Cunningham JL, Ye C, Caserta LC, Jackson N, Martinez-Sobrido L, Fang Y, Diel DG. J Virol. 2024 Mar 19;98(3):e0190223. doi: 10.1128/jvi.01902-23. Epub 2024 Feb 29. PubMed |
| The immunopathological landscape of human pre-TCRalpha deficiency: From rare to common variants. Materna M, Delmonte OM, Bosticardo M, Momenilandi M, Conrey PE, Charmeteau-De Muylder B, Bravetti C, Bellworthy R, Cederholm A, Staels F, Ganoza CA, Darko S, Sayed S, Le Floc'h C, Ogishi M, Rinchai D, Guenoun A, Bolze A, Khan T, Gervais A, Kruger R, Voller M, Palterer B, Sadeghi-Shabestari M, Langlois de Septenville A, Schramm CA, Shah S, Tello-Cajiao JJ, Pala F, Amini K, Campos JS, Lima NS, Eriksson D, Levy R, Seeleuthner Y, Jyonouchi S, Ata M, Al Ali F, Stittrich A, Deswarte C, Pereira A, Megret J, Le Voyer T, Bastard P, Berteloot L, Dussiot M, Vladikine N, Cardenas PP, Jouanguy E, Alqahtani M, Hasan A, Thanaraj TA, Rosain J, Al Qureshah F, Sabato V, Alyanakian MA, Leruez-Ville M, Rozenberg F, Haddad E, Regueiro JR, Toribio ML, Kelsen JR, Salehi M, Nasiri S, Torabizadeh M, Rokni-Zadeh H, Changi-Ashtiani M, Vatandoost N, Moravej H, Akrami SM, Mazloomrezaei M, Cobat A, Meyts I, Toyofuku E, Nishimura M, Moriya K, Mizukami T, Imai K, Abel L, Malissen B, Al-Mulla F, Alkuraya FS, Parvaneh N, von Bernuth H, Beetz C, Davi F, Douek DC, Cheynier R, Langlais D, Landegren N, Marr N, Morio T, Shahrooei M, Schrijvers R, Henrickson SE, Luche H, Notarangelo LD, Casanova JL, Beziat V. Science. 2024 Mar;383(6686):eadh4059. doi: 10.1126/science.adh4059. Epub 2024 Mar 1. PubMed |
| Sensory nerve release of CGRP increases tumor growth in HNSCC by suppressing TILs. Darragh LB, Nguyen A, Pham TT, Idlett-Ali S, Knitz MW, Gadwa J, Bukkapatnam S, Corbo S, Olimpo NA, Nguyen D, Van Court B, Neupert B, Yu J, Ross RB, Corbisiero M, Abdelazeem KNM, Maroney SP, Galindo DC, Mukdad L, Saviola A, Joshi M, White R, Alhiyari Y, Samedi V, Van Bokhoven A, St John M, Karam SD. Med. 2024 Mar 8;5(3):254-270.e8. doi: 10.1016/j.medj.2024.02.002. Epub 2024 Feb 28. PubMed |
| OrthoID: profiling dynamic proteomes through time and space using mutually orthogonal chemical tools. Lee A, Sung G, Shin S, Lee SY, Sim J, Nhung TTM, Nghi TD, Park SK, Sathieshkumar PP, Kang I, Mun JY, Kim JS, Rhee HW, Park KM, Kim K. Nat Commun. 2024 Feb 29;15(1):1851. doi: 10.1038/s41467-024-46034-z. PubMed |
| Advanced glycation end products promote meniscal calcification by activating the mTOR-ATF4 positive feedback loop. Yang S, Xie J, Pan Z, Guan H, Tu Y, Ye Y, Huang S, Fu S, Li K, Huang Z, Li X, Shi Z, Li L, Zhang Y. Exp Mol Med. 2024 Mar;56(3):630-645. doi: 10.1038/s12276-024-01190-6. Epub 2024 Mar 1. PubMed |
| CAMSAPs and nucleation-promoting factors control microtubule release from gamma-TuRC. Rai D, Song Y, Hua S, Stecker K, Monster JL, Yin V, Stucchi R, Xu Y, Zhang Y, Chen F, Katrukha EA, Altelaar M, Heck AJR, Wieczorek M, Jiang K, Akhmanova A. Nat Cell Biol. 2024 Mar;26(3):404-420. doi: 10.1038/s41556-024-01366-2. Epub 2024 Feb 29. PubMed |
| A common cellular response to broad splicing perturbations is characterized by metabolic transcript downregulation driven by the Mdm2-p53 axis. Varineau JE, Calo E. Dis Model Mech. 2024 Feb 1;17(2):dmm050356. doi: 10.1242/dmm.050356. Epub 2024 Mar 1. PubMed |
| Stromal Pbrm1 mediates chromatin remodeling necessary for embryo implantation in the mouse uterus. Xin Q, Feng I, Yu G, Dean J. J Clin Invest. 2024 Mar 1;134(5):e174194. doi: 10.1172/JCI174194. PubMed |
| Interferon lambda restricts herpes simplex virus skin disease by suppressing neutrophil-mediated pathology. Philip DT, Goins NM, Catanzaro NJ, Misumi I, Whitmire JK, Atkins HM, Lazear HM. mBio. 2024 Apr 10;15(4):e0262323. doi: 10.1128/mbio.02623-23. Epub 2024 Mar 1. PubMed |
| The CARD8 inflammasome dictates HIV/SIV pathogenesis and disease progression. Wang Q, Clark KM, Tiwari R, Raju N, Tharp GK, Rogers J, Harris RA, Raveendran M, Bosinger SE, Burdo TH, Silvestri G, Shan L. Cell. 2024 Feb 29;187(5):1223-1237.e16. doi: 10.1016/j.cell.2024.01.048. PubMed |
| Coculture with macrophages alters ferroptosis susceptibility of triple-negative cancer cells. Konishi H, Haga Y, Okumura M, Tsujino H, Higashisaka K, Tsutsumi Y. Cell Death Discov. 2024 Mar 1;10(1):108. doi: 10.1038/s41420-024-01884-w. PubMed |
| Fatty acid-binding proteins 3, 7, and 8 bind cholesterol and facilitate its egress from lysosomes. Fang XX, Wei P, Zhao K, Sheng ZC, Song BL, Yin L, Luo J. J Cell Biol. 2024 Apr 1;223(4):e202211062. doi: 10.1083/jcb.202211062. Epub 2024 Mar 1. PubMed |
| RTF2 controls replication repriming and ribonucleotide excision at the replisome. Conti BA, Ruiz PD, Broton C, Blobel NJ, Kottemann MC, Sridhar S, Lach FP, Wiley TF, Sasi NK, Carroll T, Smogorzewska A. Nat Commun. 2024 Mar 2;15(1):1943. doi: 10.1038/s41467-024-45947-z. PubMed |
| Human paraneoplastic antigen Ma2 (PNMA2) forms icosahedral capsids that can be engineered for mRNA delivery. Madigan V, Zhang Y, Raghavan R, Wilkinson ME, Faure G, Puccio E, Segel M, Lash B, Macrae RK, Zhang F. Proc Natl Acad Sci U S A. 2024 Mar 12;121(11):e2307812120. doi: 10.1073/pnas.2307812120. Epub 2024 Mar 4. PubMed |
| Trans-lesion synthesis and mismatch repair pathway crosstalk defines chemoresistance and hypermutation mechanisms in glioblastoma. Cheng X, An J, Lou J, Gu Q, Ding W, Droby GN, Wang Y, Wang C, Gao Y, Anand JR, Shelton A, Satterlee AB, Mann B, Hsiao YC, Liu CW, Lu K, Hingtgen S, Wang J, Liu Z, Miller CR, Wu D, Vaziri C, Yang Y. Nat Commun. 2024 Mar 4;15(1):1957. doi: 10.1038/s41467-024-45979-5. PubMed |
| Development and application of an indirect ELISA for detection of antibodies against emerging atypical porcine pestivirus. Song H, Gao X, Li J, Dong X, Fu Y, Shao L, Zhang J, Qiu HJ, Luo Y. Virol J. 2024 Mar 4;21(1):53. doi: 10.1186/s12985-024-02330-0. PubMed |
| Comparative analysis of human, rodent and snake deltavirus replication. Khalfi P, Denis Z, McKellar J, Merolla G, Chavey C, Ursic-Bedoya J, Soppa L, Szirovicza L, Hetzel U, Dufourt J, Leyrat C, Goldmann N, Goto K, Verrier E, Baumert TF, Glebe D, Courgnaud V, Gregoire D, Hepojoki J, Majzoub K. PLoS Pathog. 2024 Mar 5;20(3):e1012060. doi: 10.1371/journal.ppat.1012060. eCollection 2024 Mar. PubMed |
| ABCG2 transporter reduces protein aggregation in cigarette smoke condensate-exposed A549 lung cancer cells. Ajenu EO, Seideneck AM, Pandellapalli E, Shinsky EM, Humphries CL, Aparicio NL, Sharma M, Marden JH, Krasilnikova MM. PLoS One. 2024 Mar 5;19(3):e0297661. doi: 10.1371/journal.pone.0297661. eCollection 2024. PubMed |
| OSGN-1 is a conserved flavin-containing monooxygenase required to stabilize the intercellular bridge in late cytokinesis. Goupil E, Lacroix L, Briere J, Guga S, Saba-El-Leil MK, Meloche S, Labbe JC. Proc Natl Acad Sci U S A. 2024 Mar 12;121(11):e2308570121. doi: 10.1073/pnas.2308570121. Epub 2024 Mar 5. PubMed |
| Lactate dehydrogenase A regulates tumor-macrophage symbiosis to promote glioblastoma progression. Khan F, Lin Y, Ali H, Pang L, Dunterman M, Hsu WH, Frenis K, Grant Rowe R, Wainwright DA, McCortney K, Billingham LK, Miska J, Horbinski C, Lesniak MS, Chen P. Nat Commun. 2024 Mar 5;15(1):1987. doi: 10.1038/s41467-024-46193-z. PubMed |
| Neuronal miR-9 promotes HSV-1 epigenetic silencing and latency by repressing Oct-1 and Onecut family genes. Deng Y, Lin Y, Chen S, Xiang Y, Chen H, Qi S, Oh HS, Das B, Komazin-Meredith G, Pesola JM, Knipe DM, Coen DM, Pan D. Nat Commun. 2024 Mar 5;15(1):1991. doi: 10.1038/s41467-024-46057-6. PubMed |
| Non-cytopathic bovine viral diarrhea virus (BVDV) inhibits innate immune responses via induction of mitophagy. Li Z, Zhang Y, Zhao B, Xue Q, Wang C, Wan S, Wang J, Chen X, Qi X. Vet Res. 2024 Mar 5;55(1):27. doi: 10.1186/s13567-024-01284-z. PubMed |
| KLF7 regulates super-enhancer-driven IGF2BP2 overexpression to promote the progression of head and neck squamous cell carcinoma. Cai H, Liang J, Jiang Y, Wang Z, Li H, Wang W, Wang C, Hou J. J Exp Clin Cancer Res. 2024 Mar 5;43(1):69. doi: 10.1186/s13046-024-02996-y. PubMed |
| Atlas of cardiac endothelial cell enhancer elements linking the mineralocorticoid receptor to pathological gene expression. Deng L, Pollmeier L, Bednarz R, Cao C, Laurette P, Wirth L, Mamazhakypov A, Bode C, Hein L, Gilsbach R, Lother A. Sci Adv. 2024 Mar 8;10(10):eadj5101. doi: 10.1126/sciadv.adj5101. Epub 2024 Mar 6. PubMed |
| Urolithin A Hijacks ERK1/2-ULK1 Cascade to Improve CD8(+) T Cell Fitness for Antitumor Immunity. Ma S, Wu Q, Wu W, Tian Y, Zhang J, Chen C, Sheng X, Zhao F, Ding L, Wang T, Zhao L, Xie Y, Wang Y, Yue X, Wu Z, Wei J, Zhang K, Liang X, Gao L, Wang H, Wang G, Li C, Ma C. Adv Sci (Weinh). 2024 May;11(18):e2310065. doi: 10.1002/advs.202310065. Epub 2024 Mar 6. PubMed |
| Interplay Between Intracellular Transport Dynamics and Liquid‒Liquid Phase Separation. Zhang ML, Zhang Z, Niu XZ, Ti HY, Zhou YX, Gao B, Li Y, Liu JL, Chen X, Li H. Adv Sci (Weinh). 2024 May;11(19):e2308338. doi: 10.1002/advs.202308338. Epub 2024 Mar 6. PubMed |
| Targeting CCL2/CCR2 Signaling Overcomes MEK Inhibitor Resistance in Acute Myeloid Leukemia. Modak RV, de Oliveira Rebola KG, McClatchy J, Mohammadhosseini M, Damnernsawad A, Kurtz SE, Eide CA, Wu G, Laderas T, Nechiporuk T, Gritsenko MA, Hansen JR, Hutchinson C, Gosline SJC, Piehowski P, Bottomly D, Short N, Rodland K, McWeeney SK, Tyner JW, Agarwal A. Clin Cancer Res. 2024 May 15;30(10):2245-2259. doi: 10.1158/1078-0432.CCR-23-2654. PubMed |
| FAM81A is a postsynaptic protein that regulates the condensation of postsynaptic proteins via liquid-liquid phase separation. Kaizuka T, Hirouchi T, Saneyoshi T, Shirafuji T, Collins MO, Grant SGN, Hayashi Y, Takumi T. PLoS Biol. 2024 Mar 7;22(3):e3002006. doi: 10.1371/journal.pbio.3002006. eCollection 2024 Mar. PubMed |
| In vivo genome-wide CRISPR screening identifies CITED2 as a driver of prostate cancer bone metastasis. Arriaga JM, Ronaldson-Bouchard K, Picech F, Nunes de Almeida F, Afari S, Chhouri H, Vunjak-Novakovic G, Abate-Shen C. Oncogene. 2024 Apr;43(17):1303-1315. doi: 10.1038/s41388-024-02995-5. Epub 2024 Mar 7. PubMed |
| Repeat DNA methylation is modulated by adherens junction signaling. Brenner LM, Meyer F, Yang H, Kohler AR, Bashtrykov P, Guo M, Jeltsch A, Lungu C, Olayioye MA. Commun Biol. 2024 Mar 7;7(1):286. doi: 10.1038/s42003-024-05990-4. PubMed |
| S100A9(+)CD14(+) monocytes contribute to anti-PD-1 immunotherapy resistance in advanced hepatocellular carcinoma by attenuating T cell-mediated antitumor function. Tu X, Chen L, Zheng Y, Mu C, Zhang Z, Wang F, Ren Y, Duan Y, Zhang H, Tong Z, Liu L, Sun X, Zhao P, Wang L, Feng X, Fang W, Liu X. J Exp Clin Cancer Res. 2024 Mar 8;43(1):72. doi: 10.1186/s13046-024-02985-1. PubMed |
| Organelle resolved proteomics uncovers PLA2R1 as a novel cell surface marker required for chordoma growth. Khan S, Zuccato JA, Ignatchenko V, Singh O, Govindarajan M, Waas M, Mejia-Guerrero S, Gao A, Zadeh G, Kislinger T. Acta Neuropathol Commun. 2024 Mar 7;12(1):39. doi: 10.1186/s40478-024-01751-w. PubMed |
| Predicting transcription factor activity using prior biological information. Yashar WM, Estabrook J, Holly HD, Somers J, Nikolova O, Babur O, Braun TP, Demir E. iScience. 2024 Feb 5;27(3):109124. doi: 10.1016/j.isci.2024.109124. eCollection 2024 Mar 15. PubMed |
| Human papillomavirus-16 E6 activates the pentose phosphate pathway to promote cervical cancer cell proliferation by inhibiting G6PD lactylation. Meng Q, Zhang Y, Sun H, Yang X, Hao S, Liu B, Zhou H, Wang Y, Xu ZX. Redox Biol. 2024 May;71:103108. doi: 10.1016/j.redox.2024.103108. Epub 2024 Mar 1. PubMed |
| ARID1A orchestrates SWI/SNF-mediated sequential binding of transcription factors with ARID1A loss driving pre-memory B cell fate and lymphomagenesis. Barisic D, Chin CR, Meydan C, Teater M, Tsialta I, Mlynarczyk C, Chadburn A, Wang X, Sarkozy M, Xia M, Carson SE, Raggiri S, Debek S, Pelzer B, Durmaz C, Deng Q, Lakra P, Rivas M, Steidl C, Scott DW, Weng AP, Mason CE, Green MR, Melnick A. Cancer Cell. 2024 Apr 8;42(4):583-604.e11. doi: 10.1016/j.ccell.2024.02.010. Epub 2024 Mar 7. PubMed |
| SMARCA4 is a haploinsufficient B cell lymphoma tumor suppressor that fine-tunes centrocyte cell fate decisions. Deng Q, Lakra P, Gou P, Yang H, Meydan C, Teater M, Chin C, Zhang W, Dinh T, Hussein U, Li X, Rojas E, Liu W, Reville PK, Kizhakeyil A, Barisic D, Parsons S, Wilson A, Henderson J, Scull B, Gurumurthy C, Vega F, Chadburn A, Cuglievan B, El-Mallawany NK, Allen C, Mason C, Melnick A, Green MR. Cancer Cell. 2024 Apr 8;42(4):605-622.e11. doi: 10.1016/j.ccell.2024.02.011. Epub 2024 Mar 7. PubMed |
CDK-independent role of D-type cyclins in regulating DNA mismatch repair.
Rona G, Miwatani-Minter B, Zhang Q, Goldberg HV, Kerzhnerman MA, Howard JB, Simoneschi D, Lane E, Hobbs JW, Sassani E, Wang AA, Keegan S, Laverty DJ, Piett CG, Pongor LS, Xu ML, Andrade J, Thomas A, Sicinski P, Askenazi M, Ueberheide B, Fenyo D, Nagel ZD, Pagano M.
Mol Cell. 2024 Feb 29:S1097-2765(24)00129-1. doi: 10.1016/j.molcel.2024.02.010.
PubMed
Associated Plasmids |
| Adipose tissue peroxisomal lipid synthesis orchestrates obesity and insulin resistance through LXR-dependent lipogenesis. Kleiboeker B, He A, Tan M, Lu D, Hu D, Liu X, Goodarzi P, Hsu FF, Razani B, Semenkovich CF, Lodhi IJ. Mol Metab. 2024 Apr;82:101913. doi: 10.1016/j.molmet.2024.101913. Epub 2024 Mar 7. PubMed |
| Activity-dependent compartmentalization of dendritic mitochondria morphology through local regulation of fusion-fission balance in neurons in vivo. Virga DM, Hamilton S, Osei B, Morgan A, Kneis P, Zamponi E, Park NJ, Hewitt VL, Zhang D, Gonzalez KC, Russell FM, Grahame Hardie D, Prudent J, Bloss E, Losonczy A, Polleux F, Lewis TL Jr. Nat Commun. 2024 Mar 8;15(1):2142. doi: 10.1038/s41467-024-46463-w. PubMed |
An optogenetic method for the controlled release of single molecules.
Kashyap P, Bertelli S, Cao F, Kostritskaia Y, Blank F, Srikanth NA, Schlack-Leigers C, Saleppico R, Bierhuizen D, Lu X, Nickel W, Campbell RE, Plested AJR, Stauber T, Taylor MJ, Ewers H.
Nat Methods. 2024 Mar 8. doi: 10.1038/s41592-024-02204-x.
PubMed
Associated Plasmids |
| PRMT1 promotes pancreatic cancer development and resistance to chemotherapy. Ku B, Eisenbarth D, Baek S, Jeong TK, Kang JG, Hwang D, Noh MG, Choi C, Choi S, Seol T, Kim H, Kim YH, Woo SM, Kong SY, Lim DS. Cell Rep Med. 2024 Mar 19;5(3):101461. doi: 10.1016/j.xcrm.2024.101461. Epub 2024 Mar 8. PubMed |
| FLI1 induces erythroleukemia through opposing effects on UBASH3A and UBASH3B expression. Wang J, Wang C, Hu A, Yu K, Kuang Y, Gajendran B, Zacksenhaus E, Sample KM, Xiao X, Liu W, Ben-David Y. BMC Cancer. 2024 Mar 9;24(1):326. doi: 10.1186/s12885-024-12075-2. PubMed |
| Mi-2beta promotes immune evasion in melanoma by activating EZH2 methylation. Li C, Wang Z, Yao L, Lin X, Jian Y, Li Y, Zhang J, Shao J, Tran PD, Hagman JR, Cao M, Cong Y, Li HY, Goding CR, Xu ZX, Liao X, Miao X, Cui R. Nat Commun. 2024 Mar 9;15(1):2163. doi: 10.1038/s41467-024-46422-5. PubMed |
| Suppressing APOE4-induced mortality and cellular damage by targeting VHL. Jiang WI, Cao Y, Xue Y, Ji Y, Winer BY, Zhang M, Singhal NS, Pierce JT, Chen S, Ma DK. bioRxiv [Preprint]. 2024 May 10:2024.02.28.582664. doi: 10.1101/2024.02.28.582664. PubMed |
| (13)C-SpaceM: Spatial single-cell isotope tracing reveals heterogeneity of de novo fatty acid synthesis in cancer. Buglakova E, Ekelof M, Schwaiger-Haber M, Schlicker L, Molenaar MR, Mohammed S, Stuart L, Eisenbarth A, Hilsenstein V, Patti GJ, Schulze A, Snaebjornsson MT, Alexandrov T. bioRxiv [Preprint]. 2024 Feb 28:2023.08.18.553810. doi: 10.1101/2023.08.18.553810. PubMed |
| Molecular density-accelerated binding-site maturation underlies CENP-T-dependent kinetochore assembly. Tarasovetc EV, Sissoko GB, Mukhina AS, Maiorov A, Ataullakhanov FI, Cheeseman IM, Grishchuk EL. bioRxiv [Preprint]. 2024 Feb 26:2024.02.25.581584. doi: 10.1101/2024.02.25.581584. PubMed |
| The loss of OPA1 accelerates intervertebral disc degeneration and osteoarthritis in aged mice. Risbud M, Madhu V, Hernandez-Meadows M, Coleman A, Sao K, Inguito K, Haslam O, Boneski P, Sesaki H, Collins J. Res Sq [Preprint]. 2024 Feb 20:rs.3.rs-3950044. doi: 10.21203/rs.3.rs-3950044/v1. PubMed |
| Non-linear transcriptional responses to gradual modulation of transcription factor dosage. Domingo J, Minaeva M, Morris JA, Ziosi M, Sanjana NE, Lappalainen T. bioRxiv [Preprint]. 2024 Mar 3:2024.03.01.582837. doi: 10.1101/2024.03.01.582837. PubMed |
| Paxillin phase separation promotes focal adhesion assembly and integrin signaling. Liang P, Wu Y, Zheng S, Zhang J, Yang S, Wang J, Ma S, Zhang M, Gu Z, Liu Q, Jiang W, Xing Q, Wang B. J Cell Biol. 2024 Apr 1;223(4):e202209027. doi: 10.1083/jcb.202209027. Epub 2024 Mar 11. PubMed |
| USP22 regulates APL differentiation via PML-RARalpha stabilization and IFN repression. Kowald L, Roedig J, Karlowitz R, Wagner K, Smith S, Juretschke T, Beli P, Muller S, van Wijk SJL. Cell Death Discov. 2024 Mar 11;10(1):128. doi: 10.1038/s41420-024-01894-8. PubMed |
| Mitochondrial metabolism sustains CD8(+) T cell migration for an efficient infiltration into solid tumors. Simula L, Fumagalli M, Vimeux L, Rajnpreht I, Icard P, Birsen G, An D, Pendino F, Rouault A, Bercovici N, Damotte D, Lupo-Mansuet A, Alifano M, Alves-Guerra MC, Donnadieu E. Nat Commun. 2024 Mar 11;15(1):2203. doi: 10.1038/s41467-024-46377-7. PubMed |
| RNA expression of 6 genes from metastatic mucosal gastric cancer serves as the global prognostic marker for gastric cancer with functional validation. Suh YS, Lee J, George J, Seol D, Jeong K, Oh SY, Bang C, Jun Y, Kong SH, Lee HJ, Kim JI, Kim WH, Yang HK, Lee C. Br J Cancer. 2024 May;130(9):1571-1584. doi: 10.1038/s41416-024-02642-6. Epub 2024 Mar 11. PubMed |
| The role of Smarcad1 in retroviral repression in mouse embryonic stem cells. Bren I, Tal A, Strauss C, Schlesinger S. Mob DNA. 2024 Mar 11;15(1):4. doi: 10.1186/s13100-024-00314-z. PubMed |
| Cardiomyocyte-fibroblast interaction regulates ferroptosis and fibrosis after myocardial injury. Mohr ME, Li S, Trouten AM, Stairley RA, Roddy PL, Liu C, Zhang M, Sucov HM, Tao G. iScience. 2024 Feb 15;27(3):109219. doi: 10.1016/j.isci.2024.109219. eCollection 2024 Mar 15. PubMed |
| Protocol for the isolation of tumor cell-derived extracellular vesicles followed by in vivo metastasis assessment in a murine ovarian cancer model. Mittal S, Kumar S, Gupta P, Singh M, Chaluvally-Raghavan P, Pradeep S. STAR Protoc. 2024 Jun 21;5(2):102943. doi: 10.1016/j.xpro.2024.102943. Epub 2024 Mar 11. PubMed |
| Evaluation of the Role of AXL in Fusion-positive Pediatric Rhabdomyosarcoma Identifies the Small-molecule Inhibitor Bemcentinib (BGB324) as Potent Chemosensitizer. Danielli SG, Wurth J, Morice S, Kisele S, Surdez D, Delattre O, Bode PK, Wachtel M, Schafer BW. Mol Cancer Ther. 2024 Jun 4;23(6):864-876. doi: 10.1158/1535-7163.MCT-23-0285. PubMed |
| Inhalation of ACE2-expressing lung exosomes provides prophylactic protection against SARS-CoV-2. Wang Z, Hu S, Popowski KD, Liu S, Zhu D, Mei X, Li J, Hu Y, Dinh PC, Wang X, Cheng K. Nat Commun. 2024 Mar 12;15(1):2236. doi: 10.1038/s41467-024-45628-x. PubMed |
| TRIM33 Is a Co-Regulator of Estrogen Receptor Alpha. Romo BA, Karakyriakou B, Cressey L, Brauer BL, Yang H, Warren A, Johnson AL, Kettenbach AN, Miller TW. Cancers (Basel). 2024 Feb 20;16(5):845. doi: 10.3390/cancers16050845. PubMed |
| Induction of Multiple Alternative Mitogenic Signaling Pathways Accompanies the Emergence of Drug-Tolerant Cancer Cells. Celeste FV, Powers S. Cancers (Basel). 2024 Feb 29;16(5):1001. doi: 10.3390/cancers16051001. PubMed |
| Deletion of Sarcolemmal Membrane-Associated Protein Isoform 3 (SLMAP3) in Cardiac Progenitors Delays Embryonic Growth of Myocardium without Affecting Hippo Pathway. Rehmani T, Dias AP, Kamal M, Salih M, Tuana BS. Int J Mol Sci. 2024 Mar 1;25(5):2888. doi: 10.3390/ijms25052888. PubMed |
| The Impact of SLC2A8 RNA Interference on Glucose Uptake and the Transcriptome of Human Trophoblast Cells. Lipka A, Paukszto L, Kennedy VC, Tanner AR, Majewska M, Anthony RV. Cells. 2024 Feb 24;13(5):391. doi: 10.3390/cells13050391. PubMed |
| N-cadherin dynamically regulates pediatric glioma cell migration in complex environments. Kim D, Olson JM, Cooper JA. J Cell Biol. 2024 Jun 3;223(6):e202401057. doi: 10.1083/jcb.202401057. Epub 2024 Mar 13. PubMed |
| DPM1 modulates desmosomal adhesion and epidermal differentiation through SERPINB5. Rathod M, Franz H, Beyersdorfer V, Wanuske MT, Leal-Fischer K, Hanns P, Studle C, Zimmermann A, Buczak K, Schinner C, Spindler V. J Cell Biol. 2024 Apr 1;223(4):e202305006. doi: 10.1083/jcb.202305006. Epub 2024 Mar 13. PubMed |
| Bile acids modified by the intestinal microbiota promote colorectal cancer growth by suppressing CD8(+) T cell effector functions. Cong J, Liu P, Han Z, Ying W, Li C, Yang Y, Wang S, Yang J, Cao F, Shen J, Zeng Y, Bai Y, Zhou C, Ye L, Zhou R, Guo C, Cang C, Kasper DL, Song X, Dai L, Sun L, Pan W, Zhu S. Immunity. 2024 Apr 9;57(4):876-889.e11. doi: 10.1016/j.immuni.2024.02.014. Epub 2024 Mar 12. PubMed |
| RNF166 promotes colorectal cancer progression by recognizing and destabilizing poly-ADP-ribosylated angiomotins. Li Y, Zhang X, Liu N, Liu R, Zhang W, Chen L, Chen Y. Cell Death Dis. 2024 Mar 13;15(3):211. doi: 10.1038/s41419-024-06595-9. PubMed |
| PRMT5 is an actionable therapeutic target in CDK4/6 inhibitor-resistant ER+/RB-deficient breast cancer. Lin CC, Chang TC, Wang Y, Guo L, Gao Y, Bikorimana E, Lemoff A, Fang YV, Zhang H, Zhang Y, Ye D, Soria-Bretones I, Servetto A, Lee KM, Luo X, Otto JJ, Akamatsu H, Napolitano F, Mani R, Cescon DW, Xu L, Xie Y, Mendell JT, Hanker AB, Arteaga CL. Nat Commun. 2024 Mar 13;15(1):2287. doi: 10.1038/s41467-024-46495-2. PubMed |
| PRODH safeguards human naive pluripotency by limiting mitochondrial oxidative phosphorylation and reactive oxygen species production. Chen C, Liu Q, Chen W, Gong Z, Kang B, Sui M, Huang L, Wang YJ. EMBO Rep. 2024 Apr;25(4):2015-2044. doi: 10.1038/s44319-024-00110-z. Epub 2024 Mar 13. PubMed |
| p53 modulates kinase inhibitor resistance and lineage plasticity in NF1-related MPNSTs. Grit JL, McGee LE, Tovar EA, Essenburg CJ, Wolfrum E, Beddows I, Williams K, Sheridan RTC, Schipper JL, Adams M, Arumugam M, Vander Woude T, Gurunathan S, Field JM, Wulfkuhle J, Petricoin EF 3rd, Graveel CR, Steensma MR. Oncogene. 2024 May;43(19):1411-1430. doi: 10.1038/s41388-024-03000-9. Epub 2024 Mar 13. PubMed |
| Inhibition of BRD4 Attenuates ER Stress-induced Renal Ischemic-Reperfusion Injury. Diaz-Bulnes P, Rodriguez RM, Banon-Maneus E, Saiz ML, Bernet CR, Corte-Iglesias V, Ramirez-Bajo MJ, Lazo-Rodriguez M, Tamargo-Gomez I, Rodrigues-Diez RR, Sanz AB, Diaz-Corte C, Ruiz-Ortega M, Diekmann F, Aransay AM, Lopez-Larrea C, Suarez-Alvarez B. Int J Biol Sci. 2024 Feb 11;20(5):1547-1562. doi: 10.7150/ijbs.83040. eCollection 2024. PubMed |
| Mitophagy defect mediates the aging-associated hallmarks in Hutchinson-Gilford progeria syndrome. Sun Y, Xu L, Li Y, Jia S, Wang G, Cen X, Xu Y, Cao Z, Wang J, Shen N, Hu L, Zhang J, Mao J, Xia H, Liu Z, Fu X. Aging Cell. 2024 Jun;23(6):e14143. doi: 10.1111/acel.14143. Epub 2024 Mar 14. PubMed |
Continuous evolution of compact protein degradation tags regulated by selective molecular glues.
Mercer JAM, DeCarlo SJ, Roy Burman SS, Sreekanth V, Nelson AT, Hunkeler M, Chen PJ, Donovan KA, Kokkonda P, Tiwari PK, Shoba VM, Deb A, Choudhary A, Fischer ES, Liu DR.
Science. 2024 Mar 15;383(6688):eadk4422. doi: 10.1126/science.adk4422. Epub 2024 Mar 15.
PubMed
Associated Plasmids |
| The sirtuin-associated human senescence program converges on the activation of placenta-specific gene PAPPA. Bi S, Jiang X, Ji Q, Wang Z, Ren J, Wang S, Yu Y, Wang R, Liu Z, Liu J, Hu J, Sun G, Wu Z, Diao Z, Li J, Sun L, Izpisua Belmonte JC, Zhang W, Liu GH, Qu J. Dev Cell. 2024 Apr 22;59(8):991-1009.e12. doi: 10.1016/j.devcel.2024.02.008. Epub 2024 Mar 13. PubMed |
| The cholesterol biosynthesis enzyme FAXDC2 couples Wnt/beta-catenin to RTK/MAPK signaling. Madan B, Wadia SR, Patnaik S, Harmston N, Tan E, Tan IBH, Nes WD, Petretto E, Virshup DM. J Clin Invest. 2024 Jan 23;134(6):e171222. doi: 10.1172/JCI171222. PubMed |
| Vasorin Exocytosed from Glioma Cells Facilitates Angiogenesis via VEGFR2/AKT Signaling Pathway. Zhong Y, Kang H, Ma Z, Li J, Qin Z, Zhang Z, Li P, Zhong Y, Wang L. Mol Cancer Res. 2024 Jul 2;22(7):668-681. doi: 10.1158/1541-7786.MCR-23-0469. PubMed |
| De novo steroidogenesis in tumor cells drives bone metastasis and osteoclastogenesis. Sandor LF, Huh JB, Benko P, Hiraga T, Poliska S, Dobo-Nagy C, Simpson JP, Homer NZM, Mahata B, Gyori DS. Cell Rep. 2024 Mar 26;43(3):113936. doi: 10.1016/j.celrep.2024.113936. Epub 2024 Mar 13. PubMed |
| ATF3-CBS signaling axis coordinates ferroptosis and tumorigenesis in colorectal cancer. Liu J, Lu X, Zeng S, Fu R, Wang X, Luo L, Huang T, Deng X, Zheng H, Ma S, Ning D, Zong L, Lin SH, Zhang Y. Redox Biol. 2024 May;71:103118. doi: 10.1016/j.redox.2024.103118. Epub 2024 Mar 8. PubMed |
| PLEKHM2 deficiency induces impaired mitochondrial clearance and elevated ROS levels in human iPSC-derived cardiomyocytes. Zhang J, Peng Y, Fu W, Wang R, Cao J, Li S, Tian X, Li Z, Hua C, Zhai Y, Liu Y, Liu M, Sun J, Li X, Zhao X, Dong J. Cell Death Discov. 2024 Mar 15;10(1):142. doi: 10.1038/s41420-024-01907-6. PubMed |
| Activation of Bivalent Gene POU4F1 Promotes and Maintains Basal-like Breast Cancer. Zhang J, Miao N, Lao L, Deng W, Wang J, Zhu X, Huang Y, Lin H, Zeng W, Zhang W, Tan L, Yuan X, Zeng X, Zhu J, Chen X, Song E, Yang L, Nie Y, Huang D. Adv Sci (Weinh). 2024 May;11(20):e2307660. doi: 10.1002/advs.202307660. Epub 2024 Mar 16. PubMed |
| Long noncoding RNA Malat1 protects against osteoporosis and bone metastasis. Zhao Y, Ning J, Teng H, Deng Y, Sheldon M, Shi L, Martinez C, Zhang J, Tian A, Sun Y, Nakagawa S, Yao F, Wang H, Ma L. Nat Commun. 2024 Mar 16;15(1):2384. doi: 10.1038/s41467-024-46602-3. PubMed |
| Circadian coupling of mitochondria in a deep-diving mammal. Ciccone C, Kante F, Folkow LP, Hazlerigg DG, West AC, Wood SH. J Exp Biol. 2024 Apr 1;227(7):jeb246990. doi: 10.1242/jeb.246990. Epub 2024 Apr 8. PubMed |
| c-Rel is a Novel Oncogene in Lung Squamous Cell Carcinoma Regulating Cell Proliferation and Migration. Luo R, Liu Q, Hu Z, Dai W, Huang S, Xie J, Wei S, Lin C. J Cancer. 2024 Mar 4;15(8):2329-2339. doi: 10.7150/jca.93766. eCollection 2024. PubMed |
| TRIM28 facilitates type I interferon activation by targeting TBK1. Hua F, Nass T Jr, Parvatiyar K. Front Immunol. 2024 Mar 1;15:1279920. doi: 10.3389/fimmu.2024.1279920. eCollection 2024. PubMed |
| Centriole structural integrity defects are a crucial feature of Hydrolethalus Syndrome. Curinha A, Huang Z, Anglen T, Strong MA, Gliech CR, Jewett CE, Friskes A, Holland AJ. bioRxiv [Preprint]. 2024 Mar 6:2024.03.06.583733. doi: 10.1101/2024.03.06.583733. PubMed |
| Activation of the imprinted Prader-Willi Syndrome locus by CRISPR-based epigenome editing. Rohm D, Black JB, McCutcheon SR, Barrera A, Morone DJ, Nuttle X, de Esch CE, Tai DJC, Talkowski ME, Iglesias N, Gersbach CA. bioRxiv [Preprint]. 2024 Mar 4:2024.03.03.583177. doi: 10.1101/2024.03.03.583177. PubMed |
| Streptococcus pneumoniae extracellular vesicles aggravate alveolar epithelial barrier disruption via autophagic degradation of OCLN (occludin). Cui L, Yang R, Huo D, Li L, Qu X, Wang J, Wang X, Liu H, Chen H, Wang X. Autophagy. 2024 Jul;20(7):1577-1596. doi: 10.1080/15548627.2024.2330043. Epub 2024 Apr 21. PubMed |
| Ferritin heavy chain supports stability and function of the regulatory T cell lineage. Wu Q, Carlos AR, Braza F, Bergman ML, Kitoko JZ, Bastos-Amador P, Cuadrado E, Martins R, Oliveira BS, Martins VC, Scicluna BP, Landry JJ, Jung FE, Ademolue TW, Peitzsch M, Almeida-Santos J, Thompson J, Cardoso S, Ventura P, Slot M, Rontogianni S, Ribeiro V, Domingues VDS, Cabral IA, Weis S, Groth M, Ameneiro C, Fidalgo M, Wang F, Demengeot J, Amsen D, Soares MP. EMBO J. 2024 Apr;43(8):1445-1483. doi: 10.1038/s44318-024-00064-x. Epub 2024 Mar 18. PubMed |
| XPA tumor variant leads to defects in NER that sensitize cells to cisplatin. Blee AM, Gallagher KS, Kim HS, Kim M, Kharat SS, Troll CR, D'Souza A, Park J, Neufer PD, Scharer OD, Chazin WJ. NAR Cancer. 2024 Mar 18;6(1):zcae013. doi: 10.1093/narcan/zcae013. eCollection 2024 Mar. PubMed |
| MAP3K1 regulates female reproductive tract development. Kimura E, Mongan M, Xiao B, Christianto A, Wang J, Carreira VS, Bolon B, Zhang X, Burns KA, Biesiada J, Medvedovic M, Puga A, Xia Y. Dis Model Mech. 2024 Mar 1;17(3):dmm050669. doi: 10.1242/dmm.050669. Epub 2024 Mar 28. PubMed |
| Rho GTPase signaling and mDia facilitate endocytosis via presynaptic actin. Oevel K, Hohensee S, Kumar A, Rosas-Brugada I, Bartolini F, Soykan T, Haucke V. Elife. 2024 Mar 19;12:RP92755. doi: 10.7554/eLife.92755. PubMed |
| The Toxoplasma monocarboxylate transporters are involved in the metabolism within the apicoplast and are linked to parasite survival. Dong H, Yang J, He K, Zheng WB, Lai DH, Liu J, Ding HY, Wu RB, Brown KM, Hide G, Lun ZR, Zhu XQ, Long S. Elife. 2024 Mar 19;12:RP88866. doi: 10.7554/eLife.88866. PubMed |
| SMARCAL1 ubiquitylation controls its association with RPA-coated ssDNA and promotes replication fork stability. Yates M, Marois I, St-Hilaire E, Ronato DA, Djerir B, Brochu C, Morin T, Hammond-Martel I, Gezzar-Dandashi S, Casimir L, Drobetsky E, Cappadocia L, Masson JY, Wurtele H, Marechal A. PLoS Biol. 2024 Mar 19;22(3):e3002552. doi: 10.1371/journal.pbio.3002552. eCollection 2024 Mar. PubMed |
| RBBP6 maintains glioblastoma stem cells through CPSF3-dependent alternative polyadenylation. Lin P, Chen W, Long Z, Yu J, Yang J, Xia Z, Wu Q, Min X, Tang J, Cui Y, Liu F, Wang C, Zheng J, Li W, Rich JN, Li L, Xie Q. Cell Discov. 2024 Mar 19;10(1):32. doi: 10.1038/s41421-024-00654-3. PubMed |
| Inhibition of CERS1 in skeletal muscle exacerbates age-related muscle dysfunction. Wohlwend M, Laurila PP, Goeminne LJE, Lima T, Daskalaki I, Li X, von Alvensleben G, Crisol B, Mangione R, Gallart-Ayala H, Lalou A, Burri O, Butler S, Morris J, Turner N, Ivanisevic J, Auwerx J. Elife. 2024 Mar 20;12:RP90522. doi: 10.7554/eLife.90522. PubMed |
| SARS-CoV-2 Orf6 is positioned in the nuclear pore complex by Rae1 to inhibit nucleocytoplasmic transport. Makio T, Zhang K, Love N, Mast FD, Liu X, Elaish M, Hobman T, Aitchison JD, Fontoura BMA, Wozniak RW. Mol Biol Cell. 2024 May 1;35(5):ar62. doi: 10.1091/mbc.E23-10-0386. Epub 2024 Mar 20. PubMed |
| DNAJB1-PRKACA fusion neoantigens elicit rare endogenous T cell responses that potentiate cell therapy for fibrolamellar carcinoma. Kirk AM, Crawford JC, Chou CH, Guy C, Pandey K, Kozlik T, Shah RK, Chung S, Nguyen P, Zhang X, Wang J, Bell M, Mettelman RC, Allen EK, Pogorelyy MV, Kim H, Minervina AA, Awad W, Bajracharya R, White T, Long D Jr, Gordon B, Morrison M, Glazer ES, Murphy AJ, Jiang Y, Fitzpatrick EA, Yarchoan M, Sethupathy P, Croft NP, Purcell AW, Federico SM, Stewart E, Gottschalk S, Zamora AE, DeRenzo C, Strome SE, Thomas PG. Cell Rep Med. 2024 Mar 19;5(3):101469. doi: 10.1016/j.xcrm.2024.101469. PubMed |
| STAT3 couples activated tyrosine kinase signaling to the oncogenic core transcriptional regulatory circuitry of anaplastic large cell lymphoma. Prutsch N, He S, Berezovskaya A, Durbin AD, Dharia NV, Maher KA, Matthews JD, Hare L, Turner SD, Stegmaier K, Kenner L, Merkel O, Look AT, Abraham BJ, Zimmerman MW. Cell Rep Med. 2024 Mar 19;5(3):101472. doi: 10.1016/j.xcrm.2024.101472. PubMed |
| A structure-based designed small molecule depletes hRpn13(Pru) and a select group of KEN box proteins. Lu X, Chandravanshi M, Sabbasani VR, Gaikwad S, Hughitt VK, Gyabaah-Kessie N, Scroggins BT, Das S, Myint W, Clapp ME, Schwieters CD, Dyba MA, Bolhuis DL, Koscielniak JW, Andresson T, Emanuele MJ, Brown NG, Matsuo H, Chari R, Citrin DE, Mock BA, Swenson RE, Walters KJ. Nat Commun. 2024 Mar 20;15(1):2485. doi: 10.1038/s41467-024-46644-7. PubMed |
| Overexpression of Wnt5a promoted the protective effect of mesenchymal stem cells on Lipopolysaccharide-induced endothelial cell injury via activating PI3K/AKT signaling pathway. Guo M, Li S, Li C, Mao X, Tian L, Yang X, Xu C, Zeng M. BMC Infect Dis. 2024 Mar 20;24(1):335. doi: 10.1186/s12879-024-09204-4. PubMed |
| Dux activates metabolism-lactylation-MET network during early iPSC reprogramming with Brg1 as the histone lactylation reader. Hu X, Huang X, Yang Y, Sun Y, Zhao Y, Zhang Z, Qiu D, Wu Y, Wu G, Lei L. Nucleic Acids Res. 2024 Jun 10;52(10):5529-5548. doi: 10.1093/nar/gkae183. PubMed |
| Reprograming skin fibroblasts into Sertoli cells: a patient-specific tool to understand effects of genetic variants on gonadal development. Parivesh A, Delot E, Reyes A, Ryan J, Bhattacharya S, Harley V, Vilain E. Biol Sex Differ. 2024 Mar 22;15(1):24. doi: 10.1186/s13293-024-00599-y. PubMed |
| Acod1 expression in cancer cells promotes immune evasion through the generation of inhibitory peptides. Schofield JH, Longo J, Sheldon RD, Albano E, Ellis AE, Hawk MA, Murphy S, Duong L, Rahmy S, Lu X, Jones RG, Schafer ZT. Cell Rep. 2024 Apr 23;43(4):113984. doi: 10.1016/j.celrep.2024.113984. Epub 2024 Mar 24. PubMed |
| Development of a novel prostate Cancer-Stroma Sphere (CSS) model for In Vitro tumor microenvironment studies. Rakhmatullina AR, Zolotykh MA, Filina YV, Mingaleeva RN, Sagdeeva AR, Boulygina EA, Gafurbaeva DU, Bulatov ER, Rizvanov AA, Miftakhova RR. Transl Oncol. 2024 Jun;44:101930. doi: 10.1016/j.tranon.2024.101930. Epub 2024 Mar 22. PubMed |
| Activation of the insulin receptor by insulin-like growth factor 2. An W, Hall C, Li J, Hung A, Wu J, Park J, Wang L, Bai XC, Choi E. Nat Commun. 2024 Mar 23;15(1):2609. doi: 10.1038/s41467-024-46990-6. PubMed |
| Generation and utilization of endostatin-sensitive cell lines for assessing the biological activity of endostatin. Qin X, An Y, Li X, Huang F, Zhou Y, Pei D, Bi H, Shi X, Fan W, Ding Y, Li S, Li S, Wang J. MedComm (2020). 2024 Mar 23;5(4):e506. doi: 10.1002/mco2.506. eCollection 2024 Apr. PubMed |
| Oncogenic Roles of Laminin Subunit Gamma-2 in Intrahepatic Cholangiocarcinoma via Promoting EGFR Translation. Zhang J, Ji F, Tan Y, Zhao L, Zhao Y, Liu J, Shao L, Shi J, Ye M, He X, Jin J, Zhao B, Huang J, Roessler S, Zheng X, Ji J. Adv Sci (Weinh). 2024 Jun;11(21):e2309010. doi: 10.1002/advs.202309010. Epub 2024 Mar 25. PubMed |
| Hippo-signaling-controlled MHC class I antigen processing and presentation pathway potentiates antitumor immunity. Peng L, Zhou L, Li H, Zhang X, Li S, Wang K, Yang M, Ma X, Zhang D, Xiang S, Duan Y, Wang T, Sun C, Wang C, Lu D, Qian M, Wang Z. Cell Rep. 2024 Apr 23;43(4):114003. doi: 10.1016/j.celrep.2024.114003. Epub 2024 Mar 23. PubMed |
| Long-term Multimodal Recording Reveals Epigenetic Adaptation Routes in Dormant Breast Cancer Cells. Rosano D, Sofyali E, Dhiman H, Ghirardi C, Ivanoiu D, Heide T, Vingiani A, Bertolotti A, Pruneri G, Canale E, Dewhurst HF, Saha D, Slaven N, Barozzi I, Li T, Zemlyanskiy G, Phillips H, James C, Gyorffy B, Lynn C, Cresswell GD, Rehman F, Noberini R, Bonaldi T, Sottoriva A, Magnani L. Cancer Discov. 2024 May 1;14(5):866-889. doi: 10.1158/2159-8290.CD-23-1161. PubMed |
| Induction of immortal-like and functional CAR T cells by defined factors. Wang L, Jin G, Zhou Q, Liu Y, Zhao X, Li Z, Yin N, Peng M. J Exp Med. 2024 May 6;221(5):e20232368. doi: 10.1084/jem.20232368. Epub 2024 Mar 26. PubMed |
| Differential carbonic anhydrase activities control EBV-induced B-cell transformation and lytic cycle reactivation. Malik S, Biswas J, Sarkar P, Nag S, Gain C, Ghosh Roy S, Bhattacharya B, Ghosh D, Saha A. PLoS Pathog. 2024 Mar 26;20(3):e1011998. doi: 10.1371/journal.ppat.1011998. eCollection 2024 Mar. PubMed |
| Pooled CRISPR screening of high-content cellular phenotypes using ghost cytometry. Tsubouchi A, An Y, Kawamura Y, Yanagihashi Y, Nakayama H, Murata Y, Teranishi K, Ishiguro S, Aburatani H, Yachie N, Ota S. Cell Rep Methods. 2024 Mar 25;4(3):100737. doi: 10.1016/j.crmeth.2024.100737. PubMed |
| HSP47 Increases the Expression of Type I Collagen in Fibroblasts through IRE1alpha Activation, XBP1 Splicing, and Nuclear Translocation of beta-Catenin. Ham SY, Pyo MJ, Kang M, Kim YS, Lee DH, Chung JH, Lee ST. Cells. 2024 Mar 17;13(6):527. doi: 10.3390/cells13060527. PubMed |
| NPEPPS Is a Druggable Driver of Platinum Resistance. Jones RT, Scholtes M, Goodspeed A, Akbarzadeh M, Mohapatra S, Feldman LE, Vekony H, Jean A, Tilton CB, Orman MV, Romal S, Deiter C, Kan TW, Xander N, Araki SP, Joshi M, Javaid M, Clambey ET, Layer R, Laajala TD, Parker SJ, Mahmoudi T, Zuiverloon TCM, Theodorescu D, Costello JC. Cancer Res. 2024 May 15;84(10):1699-1718. doi: 10.1158/0008-5472.CAN-23-1976. PubMed |
| Activation of endogenous retroviruses and induction of viral mimicry by MEK1/2 inhibition in pancreatic cancer. Cortesi A, Gandolfi F, Arco F, Di Chiaro P, Valli E, Polletti S, Noberini R, Gualdrini F, Attanasio S, Citron F, Ho IL, Shah R, Yen EY, Spinella MC, Ronzoni S, Rodighiero S, Mitro N, Bonaldi T, Ghisletti S, Monticelli S, Viale A, Diaferia GR, Natoli G. Sci Adv. 2024 Mar 29;10(13):eadk5386. doi: 10.1126/sciadv.adk5386. Epub 2024 Mar 27. PubMed |
| iNOS is necessary for GBP-mediated T. gondii clearance in murine macrophages via vacuole nitration and intravacuolar network collapse. Zhao XY, Lempke SL, Urban Arroyo JC, Brown IG, Yin B, Magaj MM, Holness NK, Smiley J, Redemann S, Ewald SE. Nat Commun. 2024 Mar 27;15(1):2698. doi: 10.1038/s41467-024-46790-y. PubMed |
| PIP4K2B Protein Regulation by NSD1 in HPV-Negative Head and Neck Squamous Cell Carcinoma. Topchu I, Bychkov I, Roshchina E, Makhov P, Boumber Y. Cancers (Basel). 2024 Mar 17;16(6):1180. doi: 10.3390/cancers16061180. PubMed |
| Identification and Validation of a PEX5-Dependent Signature for Prognostic Prediction in Glioma. Qin X, Wang B, Lu X, Song Y, Wang W. Biomolecules. 2024 Mar 6;14(3):314. doi: 10.3390/biom14030314. PubMed |
| Silver Nanoparticles Selectively Treat Neurofibromatosis Type 1-Associated Plexiform Neurofibroma Cells at Doses That Do Not Affect Patient-Matched Schwann Cells. Attiah B, Alewine G, Easter MK, Coover RA, Fahrenholtz CD. Pharmaceutics. 2024 Mar 7;16(3):371. doi: 10.3390/pharmaceutics16030371. PubMed |
| Viral Epitope Scanning Reveals Correlation between Seasonal HCoVs and SARS-CoV-2 Antibody Responses among Cancer and Non-Cancer Patients. Lidenge SJ, Yalcin D, Bennett SJ, Ngalamika O, Kweyamba BB, Mwita CJ, Tso FY, Mwaiselage J, West JT, Wood C. Viruses. 2024 Mar 13;16(3):448. doi: 10.3390/v16030448. PubMed |
| The genetically modified human foreskin fibroblast cell line (YhFF#8) stably expressing Cas9 gene: A lab resource report. Soheilipour F, Boozarpour S, Aghaei S, Farashahi Yazd E. Int J Reprod Biomed. 2024 Feb 23;22(1):61-68. doi: 10.18502/ijrm.v22i1.15243. eCollection 2024 Jan. PubMed |
| A Crosstalk between the Receptor Tyrosine Kinase-Like Orphan Receptors ROR1/2 and S1P Signaling Pathways in Lung Cancer. Nema R, Pandey R, Kumar A. Asian Pac J Cancer Prev. 2024 Mar 1;25(3):725-733. doi: 10.31557/APJCP.2024.25.3.725. PubMed |
| Comprehensive mutational scanning of EGFR reveals TKI sensitivities of extracellular domain mutants. Hayes TK, Aquilanti E, Persky NS, Yang X, Kim EE, Brenan L, Goodale AB, Alan D, Sharpe T, Shue RE, Westlake L, Golomb L, Silverman BR, Morris MD, Fisher TR, Beyene E, Li YY, Cherniack AD, Piccioni F, Hicks JK, Chi AS, Cahill DP, Dietrich J, Batchelor TT, Root DE, Johannessen CM, Meyerson M. Nat Commun. 2024 Mar 28;15(1):2742. doi: 10.1038/s41467-024-45594-4. PubMed |
| CRISPR/Cas9 targeting of passenger single nucleotide variants in haploinsufficient or essential genes expands cancer therapy prospects. Kim H, Han JH, Kim H, Kim M, Jo SI, Lee N, Cha S, Oh MJ, Choi G, Kim HS. Sci Rep. 2024 Mar 28;14(1):7436. doi: 10.1038/s41598-024-58094-8. PubMed |
| The nuclear import receptor Kapbeta2 modifies neurotoxicity mediated by poly(GR) in C9orf72-linked ALS/FTD. Cicardi ME, Kankate V, Sriramoji S, Krishnamurthy K, Markandaiah SS, Verdone BM, Girdhar A, Nelson A, Rivas LB, Boehringer A, Haeusler AR, Pasinelli P, Guo L, Trotti D. Commun Biol. 2024 Mar 28;7(1):376. doi: 10.1038/s42003-024-06071-2. PubMed |
| Initiation of a ZAKalpha-dependent ribotoxic stress response by the innate immunity endoribonuclease RNase L. Xi J, Snieckute G, Martinez JF, Arendrup FSW, Asthana A, Gaughan C, Lund AH, Bekker-Jensen S, Silverman RH. Cell Rep. 2024 Apr 23;43(4):113998. doi: 10.1016/j.celrep.2024.113998. Epub 2024 Mar 28. PubMed |
| Gene-expression memory-based prediction of cell lineages from scRNA-seq datasets. Eisele AS, Tarbier M, Dormann AA, Pelechano V, Suter DM. Nat Commun. 2024 Mar 29;15(1):2744. doi: 10.1038/s41467-024-47158-y. PubMed |
| DEAD box RNA helicase 5 is a new pro-viral host factor for Sindbis virus infection. Messmer M, Pierson L, Pasquier C, Djordjevic N, Chicher J, Hammann P, Pfeffer S, Girardi E. Virol J. 2024 Mar 29;21(1):76. doi: 10.1186/s12985-024-02349-3. PubMed |
| VISTA drives macrophages towards a pro-tumoral phenotype that promotes cancer cell phagocytosis yet down-regulates T cell responses. Lin Y, Choukrani G, Dubbel L, Rockstein L, Freile JA, Qi Y, Wiersma V, Zhang H, Koch KW, Ammatuna E, Schuringa JJ, van Meerten T, Huls G, Bremer E. Exp Hematol Oncol. 2024 Mar 29;13(1):35. doi: 10.1186/s40164-024-00501-x. PubMed |
| BRCA1 and 53BP1 regulate reprogramming efficiency by mediating DNA repair pathway choice at replication-associated double-strand breaks. Georgieva D, Wang N, Taglialatela A, Jerabek S, Reczek CR, Lim PX, Sung J, Du Q, Horiguchi M, Jasin M, Ciccia A, Baer R, Egli D. Cell Rep. 2024 Apr 23;43(4):114006. doi: 10.1016/j.celrep.2024.114006. Epub 2024 Mar 30. PubMed |
| Spastin locally amplifies microtubule dynamics to pattern the axon for presynaptic cargo delivery. Aiken J, Holzbaur ELF. Curr Biol. 2024 Apr 22;34(8):1687-1704.e8. doi: 10.1016/j.cub.2024.03.010. Epub 2024 Mar 29. PubMed |
| TM4SF19-mediated control of lysosomal activity in macrophages contributes to obesity-induced inflammation and metabolic dysfunction. Choi C, Jeong YL, Park KM, Kim M, Kim S, Jo H, Lee S, Kim H, Choi G, Choi YH, Seong JK, Namgoong S, Chung Y, Jung YS, Granneman JG, Hyun YM, Kim JK, Lee YH. Nat Commun. 2024 Mar 30;15(1):2779. doi: 10.1038/s41467-024-47108-8. PubMed |
| An integrated framework for prognosis prediction and drug response modeling in colorectal liver metastasis drug discovery. Zhou X, Qian Y, Ling C, He Z, Shi P, Gao Y, Sui X. J Transl Med. 2024 Mar 30;22(1):321. doi: 10.1186/s12967-024-05127-5. PubMed |
| Methyl-CpG binding domain protein 2 (Mbd2) drives breast cancer progression through the modulation of epithelial-to-mesenchymal transition. Mahmood N, Arakelian A, Szyf M, Rabbani SA. Exp Mol Med. 2024 Apr;56(4):959-974. doi: 10.1038/s12276-024-01205-2. Epub 2024 Apr 1. PubMed |
| CROPseq-multi: a versatile solution for multiplexed perturbation and decoding in pooled CRISPR screens. Walton RT, Qin Y, Blainey PC. bioRxiv [Preprint]. 2024 Mar 17:2024.03.17.585235. doi: 10.1101/2024.03.17.585235. PubMed |
| Integrated in vivo functional screens and multi-omics analyses identify alpha-2,3-sialylation as essential for melanoma maintenance. Agrawal P, Chen S, de Pablos A, Jame-Chenarboo F, Miera Saenz de Vega E, Darvishian F, Osman I, Lujambio A, Mahal LK, Hernando E. bioRxiv [Preprint]. 2024 Mar 12:2024.03.08.584072. doi: 10.1101/2024.03.08.584072. PubMed |
| Functional genetics reveals modulators of anti-microtubule drug sensitivity. Su KC, Radul E, Maier NK, Tsang MJ, Goul C, Moodie B, Keys HR, Cheeseman IM. bioRxiv [Preprint]. 2024 Mar 13:2024.03.12.584469. doi: 10.1101/2024.03.12.584469. PubMed |
| Unconventional human CD61 pairing with CD103 promotes TCR signaling and antigen-specific T cell cytotoxicity. Hamid MHBA, Cespedes PF, Jin C, Chen JL, Gileadi U, Antoun E, Liang Z, Gao F, Teague R, Manoharan N, Maldonado-Perez D, Khalid-Alham N, Cerundolo L, Ciaoca R, Hester SS, Pinto-Fernandez A, Draganov SD, Vendrell I, Liu G, Yao X, Kvalvaag A, Dominey-Foy DCC, Nanayakkara C, Kanellakis N, Chen YL, Waugh C, Clark SA, Clark K, Sopp P, Rahman NM, Verrill C, Kessler BM, Ogg G, Fernandes RA, Fisher R, Peng Y, Dustin ML, Dong T. Nat Immunol. 2024 May;25(5):834-846. doi: 10.1038/s41590-024-01802-3. Epub 2024 Apr 1. PubMed |
| Glucose controls lipolysis through Golgi PtdIns4P-mediated regulation of ATGL. Ding L, Huwyler F, Long F, Yang W, Binz J, Wernle K, Pfister M, Klug M, Balaz M, Ukropcova B, Ukropec J, Wu C, Wang T, Gao M, Clavien PA, Dutkowski P, Tibbitt MW, Wolfrum C. Nat Cell Biol. 2024 Apr;26(4):552-566. doi: 10.1038/s41556-024-01386-y. Epub 2024 Apr 1. PubMed |
| Ether lipids influence cancer cell fate by modulating iron uptake. Henry WS, Muller S, Yang JS, Innes-Gold S, Das S, Reinhardt F, Sigmund K, Phadnis VV, Wan Z, Eaton E, Sampaio JL, Bell GW, Viravalli A, Hammond PT, Kamm RD, Cohen AE, Boehnke N, Hsu VW, Levental KR, Rodriguez R, Weinberg RA. bioRxiv [Preprint]. 2024 Mar 21:2024.03.20.585922. doi: 10.1101/2024.03.20.585922. PubMed |
| Activating Point Mutations in the MET Kinase Domain Represent a Unique Molecular Subset of Lung Cancer and Other Malignancies Targetable with MET Inhibitors. Pecci F, Nakazawa S, Ricciuti B, Harada G, Lee JK, Alessi JV, Barrichello A, Vaz VR, Lamberti G, Di Federico A, Gandhi MM, Gazgalis D, Feng WW, Jiang J, Baldacci S, Locquet MA, Gottlieb FH, Chen MF, Lee E, Haradon D, Smokovich A, Voligny E, Nguyen T, Goel VK, Zimmerman Z, Atwal S, Wang X, Bahcall M, Heist RS, Iqbal S, Gandhi N, Elliott A, Vanderwalde AM, Ma PC, Halmos B, Liu SV, Che J, Schrock AB, Drilon A, Janne PA, Awad MM. Cancer Discov. 2024 Aug 2;14(8):1440-1456. doi: 10.1158/2159-8290.CD-23-1217. PubMed |
| PARP2 promotes Break Induced Replication-mediated telomere fragility in response to replication stress. Muoio D, Laspata N, Dannenberg RL, Curry C, Darkoa-Larbi S, Hedglin M, Uttam S, Fouquerel E. Nat Commun. 2024 Apr 2;15(1):2857. doi: 10.1038/s41467-024-47222-7. PubMed |
| LRP1 facilitates hepatic glycogenesis by improving the insulin signaling pathway in HFD-fed mice. Guo X, Pu J, Tang Z, Jia C, Yang F, Liu T, Ding Y. Animal Model Exp Med. 2024 Oct;7(5):696-706. doi: 10.1002/ame2.12408. Epub 2024 Apr 3. PubMed |
| Recurrent mutations in tumor suppressor FBXW7 bypass Wnt/beta-catenin addiction in cancer. Zhong Z, Virshup DM. Sci Adv. 2024 Apr 5;10(14):eadk1031. doi: 10.1126/sciadv.adk1031. Epub 2024 Apr 3. PubMed |
| Targeting the GPI transamidase subunit GPAA1 abrogates the CD24 immune checkpoint in ovarian cancer. Mishra AK, Ye T, Banday S, Thakare RP, Su CT, Pham NNH, Ali A, Kulshreshtha A, Chowdhury SR, Simone TM, Hu K, Zhu LJ, Eisenhaber B, Deibler SK, Simin K, Thompson PR, Kelliher MA, Eisenhaber F, Malonia SK, Green MR. Cell Rep. 2024 Apr 23;43(4):114041. doi: 10.1016/j.celrep.2024.114041. Epub 2024 Apr 3. PubMed |
| Structural basis of ligand specificity and channel activation in an insect gustatory receptor. Frank HM, Walujkar S, Walsh RM Jr, Laursen WJ, Theobald DL, Garrity PA, Gaudet R. Cell Rep. 2024 Apr 23;43(4):114035. doi: 10.1016/j.celrep.2024.114035. Epub 2024 Apr 3. PubMed |
| Telomere dysfunction alters intestinal stem cell dynamics to promote cancer. LaBella KA, Hsu WH, Li J, Qi Y, Liu Y, Liu J, Wu CC, Liu Y, Song Z, Lin Y, Blecher JM, Jiang S, Shang X, Han J, Spring DJ, Zhang J, Xia Y, DePinho RA. Dev Cell. 2024 Jun 3;59(11):1475-1486.e5. doi: 10.1016/j.devcel.2024.03.020. Epub 2024 Apr 3. PubMed |
| An adapted protocol to derive microglia from stem cells and its application in the study of CSF1R-related disorders. Dorion MF, Casas D, Shlaifer I, Yaqubi M, Fleming P, Karpilovsky N, Chen CX, Nicouleau M, Piscopo VEC, MacDougall EJ, Alluli A, Goldsmith TM, Schneider A, Dorion S, Aprahamian N, MacDonald A, Thomas RA, Dudley RWR, Hall JA, Fon EA, Antel JP, Stratton JA, Durcan TM, La Piana R, Healy LM. Mol Neurodegener. 2024 Apr 5;19(1):31. doi: 10.1186/s13024-024-00723-x. PubMed |
| Single-nucleus transcriptomics uncovers a geroprotective role of YAP in primate gingival aging. Hu Q, Zhang B, Jing Y, Ma S, Hu L, Li J, Zheng Y, Xin Z, Peng J, Wang S, Cheng B, Qu J, Zhang W, Liu GH, Wang S. Protein Cell. 2024 Jul 20;15(8):612-632. doi: 10.1093/procel/pwae017. PubMed |
| Generation of Connexin-Expressing Stable Cell Pools. Tettey-Matey A, Di Pietro C, Donati V, Mammano F, Marazziti D. Methods Mol Biol. 2024;2801:147-176. doi: 10.1007/978-1-0716-3842-2_12. PubMed |
| Tumor cell-intrinsic epigenetic dysregulation shapes cancer-associated fibroblasts heterogeneity to metabolically support pancreatic cancer. Niu N, Shen X, Wang Z, Chen Y, Weng Y, Yu F, Tang Y, Lu P, Liu M, Wang L, Sun Y, Yang M, Shen B, Jin J, Lu Z, Jiang K, Shi Y, Xue J. Cancer Cell. 2024 May 13;42(5):869-884.e9. doi: 10.1016/j.ccell.2024.03.005. Epub 2024 Apr 4. PubMed |
| GGT5 facilitates migration and invasion through the induction of epithelial-mesenchymal transformation in gastric cancer. Luo Z, Chen Y, Chen B, Zhao Z, Wu R, Ren J. BMC Med Genomics. 2024 Apr 5;17(1):82. doi: 10.1186/s12920-024-01856-0. PubMed |
| Human iPSC 4R tauopathy model uncovers modifiers of tau propagation. Parra Bravo C, Giani AM, Madero-Perez J, Zhao Z, Wan Y, Samelson AJ, Wong MY, Evangelisti A, Cordes E, Fan L, Ye P, Zhu D, Pozner T, Mercedes M, Patel T, Yarahmady A, Carling GK, Sterky FH, Lee VMY, Lee EB, DeTure M, Dickson DW, Sharma M, Mok SA, Luo W, Zhao M, Kampmann M, Gong S, Gan L. Cell. 2024 May 9;187(10):2446-2464.e22. doi: 10.1016/j.cell.2024.03.015. Epub 2024 Apr 5. PubMed |
| Generation of human cerebral organoids with a structured outer subventricular zone. Walsh RM, Luongo R, Giacomelli E, Ciceri G, Rittenhouse C, Verrillo A, Galimberti M, Bocchi VD, Wu Y, Xu N, Mosole S, Muller J, Vezzoli E, Jungverdorben J, Zhou T, Barker RA, Cattaneo E, Studer L, Baggiolini A. Cell Rep. 2024 Apr 23;43(4):114031. doi: 10.1016/j.celrep.2024.114031. Epub 2024 Apr 6. PubMed |
| NLRP3 Cys126 palmitoylation by ZDHHC7 promotes inflammasome activation. Yu T, Hou D, Zhao J, Lu X, Greentree WK, Zhao Q, Yang M, Conde DG, Linder ME, Lin H. Cell Rep. 2024 Apr 23;43(4):114070. doi: 10.1016/j.celrep.2024.114070. Epub 2024 Apr 6. PubMed |
| Long non-coding RNA RAD51-AS1 promotes the tumorigenesis of ovarian cancer by elevating EIF5A2 expression. Zhao L, Huang J, Liu W, Su X, Zhao B, Wang X, He X. J Cancer Res Clin Oncol. 2024 Apr 7;150(4):179. doi: 10.1007/s00432-024-05671-z. PubMed |
| The subcommissural organ regulates brain development via secreted peptides. Zhang T, Ai D, Wei P, Xu Y, Bi Z, Ma F, Li F, Chen XJ, Zhang Z, Zou X, Guo Z, Zhao Y, Li JL, Ye M, Feng Z, Zhang X, Zheng L, Yu J, Li C, Tu T, Zeng H, Lei J, Zhang H, Hong T, Zhang L, Luo B, Li Z, Xing C, Jia C, Li L, Sun W, Ge WP. bioRxiv [Preprint]. 2024 Mar 31:2024.03.30.587415. doi: 10.1101/2024.03.30.587415. PubMed |
| The Scribble/SGEF/Dlg1 complex regulates the stability of apical junctions in epithelial cells. Rabino A, Awadia S, Ali N, Edson A, Garcia-Mata R. bioRxiv [Preprint]. 2024 Mar 27:2024.03.26.586884. doi: 10.1101/2024.03.26.586884. PubMed |
| Patient-derived response estimates from zero-passage organoids of luminal breast cancer. Przanowska RK, Labban N, Przanowski P, Hawes RB, Atkins KA, Showalter SL, Janes KA. bioRxiv [Preprint]. 2024 Mar 27:2024.03.24.586432. doi: 10.1101/2024.03.24.586432. PubMed |
| Human long noncoding RNA, VILMIR, is induced by major respiratory viral infections and modulates the host interferon response. John K, Huntress I, Smith E, Chou H, Tollison TS, Covarrubias S, Crisci E, Carpenter S, Peng X. bioRxiv [Preprint]. 2024 Mar 29:2024.03.25.586578. doi: 10.1101/2024.03.25.586578. PubMed |
| Mutational scanning of CRX classifies clinical variants and reveals biochemical properties of the transcriptional effector domain. Shepherdson JL, Granas DM, Li J, Shariff Z, Plassmeyer SP, Holehouse AS, White MA, Cohen BA. bioRxiv [Preprint]. 2024 Mar 27:2024.03.21.585809. doi: 10.1101/2024.03.21.585809. PubMed |
| Disruption of G-quadruplex dynamicity by BRCA2 abrogation instigates phase separation and break-induced replication at telomeres. Lee JJ, Kim H, Park H, Lee U, Kim C, Lee M, Shin Y, Jung JJ, Lee HB, Han W, Lee H. Nucleic Acids Res. 2024 Jun 10;52(10):5756-5773. doi: 10.1093/nar/gkae251. PubMed |
| Identifying human pre-mRNA cleavage and polyadenylation factors by genome-wide CRISPR screens using a dual fluorescence readthrough reporter. Ni Z, Ahmed N, Nabeel-Shah S, Guo X, Pu S, Song J, Marcon E, Burke GL, Tong AHY, Chan K, Ha KCH, Blencowe BJ, Moffat J, Greenblatt JF. Nucleic Acids Res. 2024 May 8;52(8):4483-4501. doi: 10.1093/nar/gkae240. PubMed |
| GHITM regulates malignant phenotype and sensitivity to PD-1 blockade of renal cancer cells via Notch signalling. Huang S, Liu J, Hu J, Hou Y, Hu M, Zhang B, Luo H, Fu S, Chen Y, Liu X, Chen Z, Wang L. J Cell Mol Med. 2024 Apr;28(8):e18290. doi: 10.1111/jcmm.18290. PubMed |
| SLC38A2 promotes cell proliferation and invasion by promoting glutamine metabolism in adenomyosis. Wu K, Gong W, Hu JC, Duan YC, Ke HH, Chen L. Exp Ther Med. 2024 Mar 21;27(5):218. doi: 10.3892/etm.2024.12506. eCollection 2024 May. PubMed |
| ISG12a promotes immunotherapy of HBV-associated hepatocellular carcinoma through blocking TRIM21/AKT/beta-catenin/PD-L1 axis. Deng R, Tian R, Li X, Xu Y, Li Y, Wang X, Li H, Wang L, Xu B, Yang D, Tang S, Xue B, Zuo C, Zhu H. iScience. 2024 Mar 19;27(4):109533. doi: 10.1016/j.isci.2024.109533. eCollection 2024 Apr 19. PubMed |
| ZNF397 Deficiency Triggers TET2-Driven Lineage Plasticity and AR-Targeted Therapy Resistance in Prostate Cancer. Xu Y, Yang Y, Wang Z, Sjostrom M, Jiang Y, Tang Y, Cheng S, Deng S, Wang C, Gonzalez J, Johnson NA, Li X, Li X, Metang LA, Mukherji A, Xu Q, Tirado CR, Wainwright G, Yu X, Barnes S, Hofstad M, Chen Y, Zhu H, Hanker AB, Raj GV, Zhu G, He HH, Wang Z, Arteaga CL, Liang H, Feng FY, Wang Y, Wang T, Mu P. Cancer Discov. 2024 Aug 2;14(8):1496-1521. doi: 10.1158/2159-8290.CD-23-0539. PubMed |
| Genetic interactions reveal distinct biological and therapeutic implications in breast cancer. Lin CJ, Jin X, Ma D, Chen C, Ou-Yang Y, Pei YC, Zhou CZ, Qu FL, Wang YJ, Liu CL, Fan L, Hu X, Shao ZM, Jiang YZ. Cancer Cell. 2024 Apr 8;42(4):701-719.e12. doi: 10.1016/j.ccell.2024.03.006. PubMed |
| BLM helicase unwinds lagging strand substrates to assemble the ALT telomere damage response. Jiang H, Zhang T, Kaur H, Shi T, Krishnan A, Kwon Y, Sung P, Greenberg RA. Mol Cell. 2024 May 2;84(9):1684-1698.e9. doi: 10.1016/j.molcel.2024.03.011. Epub 2024 Apr 8. PubMed |
| Pharmacological induction of chromatin remodeling drives chemosensitization in triple-negative breast cancer. Bagheri M, Mohamed GA, Mohamed Saleem MA, Ognjenovic NB, Lu H, Kolling FW, Wilkins OM, Das S, LaCroix IS, Nagaraj SH, Muller KE, Gerber SA, Miller TW, Pattabiraman DR. Cell Rep Med. 2024 Apr 16;5(4):101504. doi: 10.1016/j.xcrm.2024.101504. Epub 2024 Apr 8. PubMed |
| The clinical utility and diagnostic implementation of human subject cell transdifferentiation followed by RNA sequencing. Li S, Zhao S, Sinson JC, Bajic A, Rosenfeld JA, Neeley MB, Pena M, Worley KC, Burrage LC, Weisz-Hubshman M, Ketkar S, Craigen WJ, Clark GD, Lalani S, Bacino CA, Machol K, Chao HT, Potocki L, Emrick L, Sheppard J, Nguyen MTT, Khoramnia A, Hernandez PP, Nagamani SC, Liu Z, Eng CM, Lee B, Liu P. Am J Hum Genet. 2024 May 2;111(5):841-862. doi: 10.1016/j.ajhg.2024.03.007. Epub 2024 Apr 8. PubMed |
| Abemaciclib and Vacuolin-1 decrease aggregate-prone TDP-43 accumulation by accelerating autophagic flux. Tanaka Y, Kozuma L, Hino H, Takeya K, Eto M. Biochem Biophys Rep. 2024 Apr 1;38:101705. doi: 10.1016/j.bbrep.2024.101705. eCollection 2024 Jul. PubMed |
Messenger RNA transport on lysosomal vesicles maintains axonal mitochondrial homeostasis and prevents axonal degeneration.
De Pace R, Ghosh S, Ryan VH, Sohn M, Jarnik M, Rezvan Sangsari P, Morgan NY, Dale RK, Ward ME, Bonifacino JS.
Nat Neurosci. 2024 Apr 10. doi: 10.1038/s41593-024-01619-1.
PubMed
Associated Plasmids |
| CBX7C⋅PHC2 interaction facilitates PRC1 assembly and modulates its phase separation properties. Guan S, Tang J, Ma X, Miao R, Cheng B. iScience. 2024 Mar 21;27(4):109548. doi: 10.1016/j.isci.2024.109548. eCollection 2024 Apr 19. PubMed |
| Cooperative interaction of interferon regulatory factor -1 and bromodomain-containing protein 4 on RNA polymerase activation for intrinsic innate immunity. Xu X, Qiao D, Brasier AR. Front Immunol. 2024 Mar 27;15:1366235. doi: 10.3389/fimmu.2024.1366235. eCollection 2024. PubMed |
| A CRISPRi/a screening platform to study cellular nutrient transport in diverse microenvironments. Chidley C, Darnell AM, Gaudio BL, Lien EC, Barbeau AM, Vander Heiden MG, Sorger PK. Nat Cell Biol. 2024 May;26(5):825-838. doi: 10.1038/s41556-024-01402-1. Epub 2024 Apr 11. PubMed |
| HERC5 downregulation in non-small cell lung cancer is associated with altered energy metabolism and metastasis. Schneegans S, Loptien J, Mojzisch A, Loreth D, Kretz O, Raschdorf C, Hanssen A, Gocke A, Siebels B, Gunasekaran K, Ding Y, Oliveira-Ferrer L, Brylka L, Schinke T, Schluter H, Paatero I, Voss H, Werner S, Pantel K, Wikman H. J Exp Clin Cancer Res. 2024 Apr 11;43(1):110. doi: 10.1186/s13046-024-03020-z. PubMed |
| Identification of Four Mouse FcRn Splice Variants and FcRn-Specific Vesicles. Haddad G, Blaine J. Cells. 2024 Mar 29;13(7):594. doi: 10.3390/cells13070594. PubMed |
| Unveiling IL6R and MYC as Targeting Biomarkers in Imatinib-Resistant Chronic Myeloid Leukemia through Advanced Non-Invasive Apoptosis Detection Sensor Version 2 Detection. Lee CH, Hsu KW, Hsieh YY, Li WT, Long Y, Lin CY, Chen SH. Cells. 2024 Apr 2;13(7):616. doi: 10.3390/cells13070616. PubMed |
| Porcine reproductive and respiratory syndrome virus 2 hijacks CMA-mediated lipolysis through upregulation of small GTPase RAB18. Li GL, Han YQ, Su BQ, Yu HS, Zhang S, Yang GY, Wang J, Liu F, Ming SL, Chu BB. PLoS Pathog. 2024 Apr 12;20(4):e1012123. doi: 10.1371/journal.ppat.1012123. eCollection 2024 Apr. PubMed |
| Augmented ERO1alpha upon mTORC1 activation induces ferroptosis resistance and tumor progression via upregulation of SLC7A11. Wang Z, Zong H, Liu W, Lin W, Sun A, Ding Z, Chen X, Wan X, Liu Y, Hu Z, Zhang H, Li H, Liu Y, Li D, Zhang S, Zha X. J Exp Clin Cancer Res. 2024 Apr 13;43(1):112. doi: 10.1186/s13046-024-03039-2. PubMed |
| Synergy between BRD9- and IKZF3-Targeting as a Therapeutic Strategy for Multiple Myeloma. Chowdhury B, Garg S, Ni W, Sattler M, Sanchez D, Meng C, Akatsu T, Stone R, Forrester W, Harrington E, Buhrlage SJ, Griffin JD, Weisberg E. Cancers (Basel). 2024 Mar 28;16(7):1319. doi: 10.3390/cancers16071319. PubMed |
| FL118 Is a Potent Therapeutic Agent against Chronic Myeloid Leukemia Resistant to BCR-ABL Inhibitors through Targeting RNA Helicase DDX5. Takeda K, Ohta S, Nagao M, Kobayashi E, Tago K, Funakoshi-Tago M. Int J Mol Sci. 2024 Mar 26;25(7):3693. doi: 10.3390/ijms25073693. PubMed |
| Transmembrane Protein TMEM230, Regulator of Glial Cell Vascular Mimicry and Endothelial Cell Angiogenesis in High-Grade Heterogeneous Infiltrating Gliomas and Glioblastoma. Cocola C, Abeni E, Martino V, Piscitelli E, Pelucchi P, Mosca E, Chiodi A, Mohamed T, Palizban M, Porta G, Palizban H, Nano G, Acquati F, Bruno A, Greve B, Gerovska D, Magnaghi V, Mazzaccaro D, Bertalot G, Kehler J, Balbino C, Arauzo-Bravo MJ, Gotte M, Zucchi I, Reinbold RA. Int J Mol Sci. 2024 Apr 3;25(7):3967. doi: 10.3390/ijms25073967. PubMed |
| Squalene-epoxidase-catalyzed 24(S),25-epoxycholesterol synthesis promotes trained-immunity-mediated antitumor activity. Liu Y, Wang Z, Jin H, Cui L, Huo B, Xie C, Li J, Ding H, Zhang H, Xiong W, Li M, Zhang H, Guo H, Li C, Wang T, Wang X, He W, Wang Z, Bei JX, Huang P, Liu J, Xia X. Cell Rep. 2024 Apr 23;43(4):114094. doi: 10.1016/j.celrep.2024.114094. Epub 2024 Apr 11. PubMed |
| SHIP inhibition mediates select TREM2-induced microglial functions. Ramakrishnan GS, Berry WL, Pacherille A, Kerr WG, Chisholm JD, Pedicone C, Humphrey MB. Mol Immunol. 2024 Jun;170:35-45. doi: 10.1016/j.molimm.2024.04.002. Epub 2024 Apr 12. PubMed |
| Targeting high circDNA2v levels in colorectal cancer induces cellular senescence and elicits an anti-tumor secretome. Wu S, Dai X, Xia Y, Zhao Q, Zhao H, Shi Z, Yin X, Liu X, Zhang A, Yao Z, Zhang H, Li Q, Thorne RF, Zhang S, Sheng W, Hu W, Gu H. Cell Rep. 2024 Apr 23;43(4):114111. doi: 10.1016/j.celrep.2024.114111. Epub 2024 Apr 12. PubMed |
| A mechanism that transduces lysosomal damage signals to stress granule formation for cell survival. Duran J, Poolsup S, Allers L, Lemus MR, Cheng Q, Pu J, Salemi M, Phinney B, Jia J. bioRxiv [Preprint]. 2024 Apr 2:2024.03.29.587368. doi: 10.1101/2024.03.29.587368. PubMed |
| Photophysics-informed two-photon voltage imaging using FRET-opsin voltage indicators. Brooks FP 3rd, Davis HC, Park P, Qi Y, Cohen AE. bioRxiv [Preprint]. 2024 Apr 2:2024.04.01.587540. doi: 10.1101/2024.04.01.587540. PubMed |
| The RNA-binding protein RBMS3 inhibits the progression of colon cancer by regulating the stability of LIMS1 mRNA. Li Y, Wang S, Li G, Gao C, Cui Z, Cong M, Hu J, Zhang M, Jin X, Sun H, Kong D. Cancer Med. 2024 Apr;13(7):e7129. doi: 10.1002/cam4.7129. PubMed |
| Latent Epstein-Barr virus infection collaborates with Myc over-expression in normal human B cells to induce Burkitt-like Lymphomas in mice. Bristol JA, Nelson SE, Ohashi M, Casco A, Hayes M, Ranheim EA, Pawelski AS, Singh DR, Hodson DJ, Johannsen EC, Kenney SC. PLoS Pathog. 2024 Apr 15;20(4):e1012132. doi: 10.1371/journal.ppat.1012132. eCollection 2024 Apr. PubMed |
| Abscisic acid signaling through LANCL2 and PPARgamma induces activation of p38MAPK resulting in dormancy of prostate cancer metastatic cells. Parajuli KR, Jung Y, Taichman RS. Oncol Rep. 2024 Mar;51(3):39. doi: 10.3892/or.2024.8698. Epub 2024 Jan 12. PubMed |
| Differential nanoscale organization of excitatory synapses onto excitatory vs. inhibitory neurons. Dharmasri PA, Levy AD, Blanpied TA. Proc Natl Acad Sci U S A. 2024 Apr 23;121(17):e2315379121. doi: 10.1073/pnas.2315379121. Epub 2024 Apr 16. PubMed |
| Efficient deletion of microRNAs using CRISPR/Cas9 with dual guide RNAs. Ijee S, Chambayil K, Chaudhury AD, Bagchi A, Modak K, Das S, Benjamin ESB, Rani S, Paul DZ, Nath A, Roy D, Palani D, Priyanka S, Ravichandran R, Kumary BK, Sivamani Y, S V, Babu D, Nakamura Y, Thamodaran V, Balasubramanian P, Velayudhan SR. Front Mol Biosci. 2024 Apr 2;10:1295507. doi: 10.3389/fmolb.2023.1295507. eCollection 2023. PubMed |
| circRNA-PTPN4 mediated regulation of FOXO3 and ZO-1 expression: implications for blood-brain barrier integrity and cognitive function in uremic encephalopathy. Liu Y, Qin Y, Zhang Y. Cell Biol Toxicol. 2024 Apr 17;40(1):22. doi: 10.1007/s10565-024-09865-6. PubMed |
| A p85 isoform switch enhances PI3K activation on endosomes by a MAP4- and PI3P-dependent mechanism. Thapa N, Chen M, Cryns VL, Anderson R. Cell Rep. 2024 May 28;43(5):114119. doi: 10.1016/j.celrep.2024.114119. Epub 2024 Apr 16. PubMed |
| TAK1 inhibition leads to RIPK1-dependent apoptosis in immune-activated cancers. Damhofer H, Tatar T, Southgate B, Scarneo S, Agger K, Shlyueva D, Uhrbom L, Morrison GM, Hughes PF, Haystead T, Pollard SM, Helin K. Cell Death Dis. 2024 Apr 17;15(4):273. doi: 10.1038/s41419-024-06654-1. PubMed |
| epHero - a tandem-fluorescent probe to track the fate of apoptotic cells during efferocytosis. Singh S, Bensalem J, Hein LK, Casey A, Makinen VP, Sargeant TJ. Cell Death Discov. 2024 Apr 17;10(1):179. doi: 10.1038/s41420-024-01952-1. PubMed |
| Modulation of alveolar macrophage and mitochondrial fitness by medicinal plant-derived nanovesicles to mitigate acute lung injury and viral pneumonia. Ye L, Gao Y, Mok SWF, Liao W, Wang Y, Chen C, Yang L, Zhang J, Shi L. J Nanobiotechnology. 2024 Apr 18;22(1):190. doi: 10.1186/s12951-024-02473-w. PubMed |
| RBM22 regulates RNA polymerase II 5' pausing, elongation rate, and termination by coordinating 7SK-P-TEFb complex and SPT5. Du X, Qin W, Yang C, Dai L, San M, Xia Y, Zhou S, Wang M, Wu S, Zhang S, Zhou H, Li F, He F, Tang J, Chen JY, Zhou Y, Xiao R. Genome Biol. 2024 Apr 19;25(1):102. doi: 10.1186/s13059-024-03242-6. PubMed |
| Classification and functional characterization of regulators of intracellular STING trafficking identified by genome-wide optical pooled screening. Gentili M, Carlson RJ, Liu B, Hellier Q, Andrews J, Qin Y, Blainey PC, Hacohen N. bioRxiv [Preprint]. 2024 Apr 9:2024.04.07.588166. doi: 10.1101/2024.04.07.588166. PubMed |
| The neuroendocrine transition in prostate cancer is dynamic and dependent on ASCL1. Romero R, Chu T, Gonzalez-Robles TJ, Smith P, Xie Y, Kaur H, Yoder S, Zhao H, Mao C, Kang W, Pulina MV, Lawrence KE, Gopalan A, Zaidi S, Yoo K, Choi J, Fan N, Gerstner O, Karthaus WR, DeStanchina E, Ruggles KV, Westcott PMK, Chaligne R, Pe'er D, Sawyers CL. bioRxiv [Preprint]. 2024 Apr 11:2024.04.09.588557. doi: 10.1101/2024.04.09.588557. PubMed |
| CK2alpha-mediated phosphorylation of GRP94 facilitates the metastatic cascade in triple-negative breast cancer. Kim HY, Kim YM, Hong S. Cell Death Discov. 2024 Apr 22;10(1):185. doi: 10.1038/s41420-024-01956-x. PubMed |
| NKX2-5 regulates vessel remodeling in scleroderma-associated pulmonary arterial hypertension. Papaioannou I, Dritsoula A, Kang P, Baliga RS, Trinder SL, Cook E, Shiwen X, Hobbs AJ, Denton CP, Abraham DJ, Ponticos M. JCI Insight. 2024 Apr 23;9(10):e164191. doi: 10.1172/jci.insight.164191. PubMed |
| Sedentary behavior in mice induces metabolic inflexibility by suppressing skeletal muscle pyruvate metabolism. Siripoksup P, Cao G, Cluntun AA, Maschek JA, Pearce Q, Brothwell MJ, Jeong MY, Eshima H, Ferrara PJ, Opurum PC, Mahmassani ZS, Peterlin AD, Watanabe S, Walsh MA, Taylor EB, Cox JE, Drummond MJ, Rutter J, Funai K. J Clin Invest. 2024 Apr 23;134(11):e167371. doi: 10.1172/JCI167371. PubMed |
| Integrated drug profiling and CRISPR screening identify BCR::ABL1-independent vulnerabilities in chronic myeloid leukemia. Adnan Awad S, Dufva O, Klievink J, Karjalainen E, Ianevski A, Pietarinen P, Kim D, Potdar S, Wolf M, Lotfi K, Aittokallio T, Wennerberg K, Porkka K, Mustjoki S. Cell Rep Med. 2024 May 21;5(5):101521. doi: 10.1016/j.xcrm.2024.101521. Epub 2024 Apr 22. PubMed |
| Targeting NRAS via miR-1304-5p or farnesyltransferase inhibition confers sensitivity to ALK inhibitors in ALK-mutant neuroblastoma. Pucci P, Lee LC, Han M, Matthews JD, Jahangiri L, Schlederer M, Manners E, Sorby-Adams A, Kaggie J, Trigg RM, Steel C, Hare L, James ER, Prokoph N, Ducray SP, Merkel O, Rifatbegovic F, Luo J, Taschner-Mandl S, Kenner L, Burke GAA, Turner SD. Nat Commun. 2024 Apr 23;15(1):3422. doi: 10.1038/s41467-024-47771-x. PubMed |
| BAG3 regulates cilia homeostasis of glioblastoma via its WW domain. Roth C, Paulini L, Hoffmann ME, Mosler T, Dikic I, Brunschweiger A, Korschgen H, Behl C, Linder B, Kogel D. Biofactors. 2024 Apr 24. doi: 10.1002/biof.2060. PubMed |
| IGSF8 is an innate immune checkpoint and cancer immunotherapy target. Li Y, Wu X, Sheng C, Liu H, Liu H, Tang Y, Liu C, Ding Q, Xie B, Xiao X, Zheng R, Yu Q, Guo Z, Ma J, Wang J, Gao J, Tian M, Wang W, Zhou J, Jiang L, Gu M, Shi S, Paull M, Yang G, Yang W, Landau S, Bao X, Hu X, Liu XS, Xiao T. Cell. 2024 May 23;187(11):2703-2716.e23. doi: 10.1016/j.cell.2024.03.039. Epub 2024 Apr 23. PubMed |
Synthetic protein circuits for programmable control of mammalian cell death.
Xia S, Lu AC, Tobin V, Luo K, Moeller L, Shon DJ, Du R, Linton JM, Sui M, Horns F, Elowitz MB.
Cell. 2024 Apr 16:S0092-8674(24)00347-7. doi: 10.1016/j.cell.2024.03.031.
PubMed
Associated Plasmids |
| Genome-wide CRISPR screens identify the YAP/TEAD axis as a driver of persister cells in EGFR mutant lung cancer. Pfeifer M, Brammeld JS, Price S, Pilling J, Bhavsar D, Farcas A, Bateson J, Sundarrajan A, Miragaia RJ, Guan N, Arnold S, Tariq L, Grondine M, Talbot S, Guerriero ML, O'Neill DJ, Young J, Company C, Dunn S, Thorpe H, Martin MJ, Maratea K, Barrell D, Ahdesmaki M, Mettetal JT, Brownell J, McDermott U. Commun Biol. 2024 Apr 24;7(1):497. doi: 10.1038/s42003-024-06190-w. PubMed |
| Ribosomal S6 kinase 2-forkhead box protein O4 signaling pathway plays an essential role in melanogenesis. Jeung D, Lee GE, Chen W, Byun J, Nam SB, Park YM, Lee HS, Kang HC, Lee JY, Kim KD, Hong YS, Lee CJ, Kim DJ, Cho YY. Sci Rep. 2024 Apr 24;14(1):9440. doi: 10.1038/s41598-024-60165-9. PubMed |
| Spatiotemporal proteomic profiling of cellular responses to NLRP3 agonists. Hollingsworth LR, Veeraraghavan P, Paulo JA, Harper JW, Rauch I. bioRxiv [Preprint]. 2024 Apr 20:2024.04.19.590338. doi: 10.1101/2024.04.19.590338. PubMed |
| Tumorigenesis driven by the BRAF(V600E) oncoprotein requires secondary mutations that overcome its feedback inhibition of migration and invasion. Gadal S, Boyer JA, Roy SF, Outmezguine NA, Sharma M, Li H, Fan N, Chan E, Romin Y, Barlas A, Chang Q, Pancholi P, Timaul NM, Overholtzer M, Yaeger R, Manova-Todorova K, de Stanchina E, Bosenberg M, Rosen N. bioRxiv [Preprint]. 2024 Apr 20:2023.11.21.568071. doi: 10.1101/2023.11.21.568071. PubMed |
| DOT1-like histone lysine methyltransferase is critical for adult vessel maintenance and functions. Lee H, Han DW, La H, Park C, Kang K, Kwon O, Uhm SJ, Song H, Do JT, Choi Y, Hong K. Anim Biosci. 2024 Sep;37(9):1635-1643. doi: 10.5713/ab.23.0402. Epub 2024 Apr 24. PubMed |
| CRISPR-Cas9 screening identifies INTS3 as an anti-apoptotic RNA-binding protein and therapeutic target for colorectal cancer. Wang Z, Zhang C, Guo J, Yang Y, Li P, Wang Z, Liu S, Zhang L, Zeng X, Zhai J, Wang X, Zhao Q, Chen Z, Zhu P, He Q. iScience. 2024 Apr 6;27(5):109676. doi: 10.1016/j.isci.2024.109676. eCollection 2024 May 17. PubMed |
| Establishment and Characterization of SV40 T-Antigen Immortalized Porcine Muscle Satellite Cell. Ni M, He J, Li T, Zhao G, Ji Z, Ren F, Leng J, Wu M, Huang R, Li P, Hou L. Cells. 2024 Apr 18;13(8):703. doi: 10.3390/cells13080703. PubMed |
| Positive selection CRISPR screens reveal a druggable pocket in an oligosaccharyltransferase required for inflammatory signaling to NF-kappaB. Lampson BL, Ramiotarez AS, Baro M, He L, Hegde M, Koduri V, Pfaff JL, Hanna RE, Kowal J, Shirole NH, He Y, Doench JG, Contessa JN, Locher KP, Kaelin WG Jr. Cell. 2024 Apr 25;187(9):2209-2223.e16. doi: 10.1016/j.cell.2024.03.022. PubMed |
| Collagen IV assembly is influenced by fluid flow in kidney cell-derived matrices. Tian P, Koudis NM, Morais MRPT, Pickard A, Fresquet M, Adamson A, Derby B, Lennon R. Cells Dev. 2024 Apr 24:203923. doi: 10.1016/j.cdev.2024.203923. PubMed |
| IL-6 promotes tumor growth through immune evasion but is dispensable for cachexia. Kwon YY, Hui S. EMBO Rep. 2024 Jun;25(6):2592-2609. doi: 10.1038/s44319-024-00144-3. Epub 2024 Apr 26. PubMed |
| SCF(FBXW11) Complex Targets Interleukin-17 Receptor A for Ubiquitin-Proteasome-Mediated Degradation. Jin B, Moududee SA, Ge D, Zhou P, Wang AR, Liu YZ, You Z. Biomedicines. 2024 Mar 28;12(4):755. doi: 10.3390/biomedicines12040755. PubMed |
| Chromatin Profiles Are Prognostic of Clinical Response to Bortezomib-Containing Chemotherapy in Pediatric Acute Myeloid Leukemia: Results from the COG AAML1031 Trial. van Dijk AD, Hoff FW, Qiu Y, Hubner SE, Go RL, Ruvolo VR, Leonti AR, Gerbing RB, Gamis AS, Aplenc R, Kolb EA, Alonzo TA, Meshinchi S, de Bont ESJM, Horton TM, Kornblau SM. Cancers (Basel). 2024 Apr 9;16(8):1448. doi: 10.3390/cancers16081448. PubMed |
| Missing WD40 Repeats in ATG16L1 Delays Canonical Autophagy and Inhibits Noncanonical Autophagy. Tang J, Fang D, Zhong J, Li M. Int J Mol Sci. 2024 Apr 19;25(8):4493. doi: 10.3390/ijms25084493. PubMed |
| Residue K28 of Zika Virus NS5 Protein Is Implicated in Virus Replication and Antagonism of STAT2. Peng NYG, Sng JDJ, Setoh YX, Khromykh AA. Microorganisms. 2024 Mar 26;12(4):660. doi: 10.3390/microorganisms12040660. PubMed |
| Loss of NEDD8 in cancer cells causes vulnerability to immune checkpoint blockade in triple-negative breast cancer. Papakyriacou I, Kutkaite G, Rubies Bedos M, Nagarajan D, Alford LP, Menden MP, Mao Y. Nat Commun. 2024 Apr 27;15(1):3581. doi: 10.1038/s41467-024-47987-x. PubMed |
| MHC class I-dressing is mediated via phosphatidylserine recognition and is enhanced by polyI:C. Hori A, Toyoura S, Fujiwara M, Taniguchi R, Kano Y, Yamano T, Hanayama R, Nakayama M. iScience. 2024 Apr 10;27(5):109704. doi: 10.1016/j.isci.2024.109704. eCollection 2024 May 17. PubMed |
| Ribosome subunit attrition and activation of the p53-MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition. Howard GC, Wang J, Rose KL, Jones C, Patel P, Tsui T, Florian AC, Vlach L, Lorey SL, Grieb BC, Smith BN, Slota MJ, Reynolds EM, Goswami S, Savona MR, Mason FM, Lee T, Fesik S, Liu Q, Tansey WP. Elife. 2024 Apr 29;12:RP90683. doi: 10.7554/eLife.90683. PubMed |
| Germinal center cytokine driven epigenetic control of Epstein-Barr virus latency gene expression. Liao Y, Yan J, Beri NR, Giulino-Roth L, Cesarman E, Gewurz BE. PLoS Pathog. 2024 Apr 29;20(4):e1011939. doi: 10.1371/journal.ppat.1011939. eCollection 2024 Apr. PubMed |
| Glucose hypometabolism prompts RAN translation and exacerbates C9orf72-related ALS/FTD phenotypes. Nelson AT, Cicardi ME, Markandaiah SS, Han JY, Philp NJ, Welebob E, Haeusler AR, Pasinelli P, Manfredi G, Kawamata H, Trotti D. EMBO Rep. 2024 May;25(5):2479-2510. doi: 10.1038/s44319-024-00140-7. Epub 2024 Apr 29. PubMed |
| Germline cis variant determines epigenetic regulation of the anti-cancer drug metabolism gene dihydropyrimidine dehydrogenase (DPYD). Zhang T, Ambrodji A, Huang H, Bouchonville KJ, Etheridge AS, Schmidt RE, Bembenek BM, Temesgen ZB, Wang Z, Innocenti F, Stroka D, Diasio RB, Largiader CR, Offer SM. Elife. 2024 Apr 30;13:RP94075. doi: 10.7554/eLife.94075. PubMed |
| GPATCH8 modulates mutant SF3B1 mis-splicing and pathogenicity in hematologic malignancies. Benbarche S, Pineda JMB, Galvis LB, Biswas J, Liu B, Wang E, Zhang Q, Hogg SJ, Lyttle K, Dahi A, Lewis AM, Sarchi M, Rahman J, Fox N, Ai Y, Mehta S, Garippa R, Ortiz-Pacheco J, Li Z, Monetti M, Stanley RF, Doulatov S, Bradley RK, Abdel-Wahab O. Mol Cell. 2024 May 16;84(10):1886-1903.e10. doi: 10.1016/j.molcel.2024.04.006. Epub 2024 Apr 29. PubMed |
| The Mediator Med23 controls a transcriptional switch for muscle stem cell proliferation and differentiation in muscle regeneration. Fang Y, Yuan C, Li C, Lu C, Yu W, Wang G. Cell Rep. 2024 May 28;43(5):114177. doi: 10.1016/j.celrep.2024.114177. Epub 2024 Apr 30. PubMed |
| SETDB1 modulates the TGFbeta response in Duchenne muscular dystrophy myotubes. Granados A, Zamperoni M, Rapone R, Moulin M, Boyarchuk E, Bouyioukos C, Del Maestro L, Joliot V, Negroni E, Mohamed M, Piquet S, Bigot A, Le Grand F, Albini S, Ait-Si-Ali S. Sci Adv. 2024 May 3;10(18):eadj8042. doi: 10.1126/sciadv.adj8042. Epub 2024 May 1. PubMed |
| The role of age-associated alpha-synuclein aggregation in a conditional transgenic mouse model of Parkinson's disease: Implications for Lewy body formation. Li J, Ng KW, Sung CC, Chung KKK. J Neurochem. 2024 Jul;168(7):1215-1236. doi: 10.1111/jnc.16122. Epub 2024 May 1. PubMed |
| The epigenetic regulators EP300/CREBBP represent promising therapeutic targets in MLL-rearranged acute myeloid leukemia. Wu W, Jiang Y, Xing D, Zhai Y, Sun H, He X, Luo K, Xu P, Pan F, Dong G, Ren G, Zhao Z. Cell Death Discov. 2024 May 1;10(1):206. doi: 10.1038/s41420-024-01940-5. PubMed |
| An intricate regulatory circuit between FLI1 and GATA1/GATA2/LDB1/ERG dictates erythroid vs. megakaryocytic differentiation. Wang C, Hu M, Yu K, Liu W, Hu A, Kuang Y, Huang L, Gajendran B, Zacksenhaus E, Xiao X, Ben-David Y. Mol Med Rep. 2024 Jun;29(6):107. doi: 10.3892/mmr.2024.13231. Epub 2024 May 2. PubMed |
| KSHV genome harbors both constitutive and lytically induced enhancers. Roy Chowdhury N, Gurevich V, Shamay M. J Virol. 2024 Jun 13;98(6):e0017924. doi: 10.1128/jvi.00179-24. Epub 2024 May 2. PubMed |
Epistatic interactions between NMD and TRP53 control progenitor cell maintenance and brain size.
Lin L, Zhao J, Kubota N, Li Z, Lam YL, Nguyen LP, Yang L, Pokharel SP, Blue SM, Yee BA, Chen R, Yeo GW, Chen CW, Chen L, Zheng S.
Neuron. 2024 Jul 3;112(13):2157-2176.e12. doi: 10.1016/j.neuron.2024.04.006. Epub 2024 May 1.
PubMed
Associated Plasmids |
| Expression of nuclear receptor co‑activator 7 protein is associated with poor prognosis of breast cancer. Peng Z, Li Y, Xia S, Dai Q, Yin L, Chen M, Yang W, Shao G, Lin Q. Oncol Lett. 2024 Apr 23;27(6):278. doi: 10.3892/ol.2024.14411. eCollection 2024 Jun. PubMed |
| The anti-leprosy drug clofazimine reduces polyQ toxicity through activation of PPARgamma. Li X, Hernandez I, Koyuncu S, Kis B, Haggblad M, Lidemalm L, Abbas AA, Bendeguz S, Goblos A, Brautigam L, Lucas JJ, Carreras-Puigvert J, Huhn D, Pircs K, Vilchez D, Fernandez-Capetillo O. EBioMedicine. 2024 May;103:105124. doi: 10.1016/j.ebiom.2024.105124. Epub 2024 May 2. PubMed |
| TCF19 promotes cell proliferation and tumor formation in lung cancer by activating the Raf/MEK/ERK signaling pathway. Tian Y, Xin S, Wan Z, Dong H, Liu L, Fan Z, Li T, Peng F, Xiong Y, Han Y. Transl Oncol. 2024 Jul;45:101978. doi: 10.1016/j.tranon.2024.101978. Epub 2024 May 2. PubMed |
| FLT3L governs the development of partially overlapping hematopoietic lineages in humans and mice. Momenilandi M, Levy R, Sobrino S, Li J, Lagresle-Peyrou C, Esmaeilzadeh H, Fayand A, Le Floc'h C, Guerin A, Della Mina E, Shearer D, Delmonte OM, Yatim A, Mulder K, Mancini M, Rinchai D, Denis A, Neehus AL, Balogh K, Brendle S, Rokni-Zadeh H, Changi-Ashtiani M, Seeleuthner Y, Deswarte C, Bessot B, Cremades C, Materna M, Cederholm A, Ogishi M, Philippot Q, Beganovic O, Ackermann M, Wuyts M, Khan T, Fouere S, Herms F, Chanal J, Palterer B, Bruneau J, Molina TJ, Leclerc-Mercier S, Pretet JL, Youssefian L, Vahidnezhad H, Parvaneh N, Claeys KG, Schrijvers R, Luka M, Perot P, Fourgeaud J, Nourrisson C, Poirier P, Jouanguy E, Boisson-Dupuis S, Bustamante J, Notarangelo LD, Christensen N, Landegren N, Abel L, Marr N, Six E, Langlais D, Waterboer T, Ginhoux F, Ma CS, Tangye SG, Meyts I, Lachmann N, Hu J, Shahrooei M, Bossuyt X, Casanova JL, Beziat V. Cell. 2024 May 23;187(11):2817-2837.e31. doi: 10.1016/j.cell.2024.04.009. Epub 2024 May 3. PubMed |
| Molecular targets of glucocorticoids that elucidate their therapeutic efficacy in aggressive lymphomas. Choi J, Ceribelli M, Phelan JD, Haupl B, Huang DW, Wright GW, Hsiao T, Morris V, Ciccarese F, Wang B, Corcoran S, Scheich S, Yu X, Xu W, Yang Y, Zhao H, Zhou J, Zhang G, Muppidi J, Inghirami GG, Oellerich T, Wilson WH, Thomas CJ, Staudt LM. Cancer Cell. 2024 May 13;42(5):833-849.e12. doi: 10.1016/j.ccell.2024.04.007. Epub 2024 May 2. PubMed |
| Modeling and therapeutic targeting of t(8;21) AML with/without TP53 deficiency. Zhang W, Li J, Yamamoto K, Goyama S. Int J Hematol. 2024 Aug;120(2):186-193. doi: 10.1007/s12185-024-03783-3. Epub 2024 May 3. PubMed |
| ETV4 is a mechanical transducer linking cell crowding dynamics to lineage specification. Yang S, Golkaram M, Oh S, Oh Y, Cho Y, Yoe J, Ju S, Lalli MA, Park SY, Lee Y, Jang J. Nat Cell Biol. 2024 Jun;26(6):903-916. doi: 10.1038/s41556-024-01415-w. Epub 2024 May 3. PubMed |
| The MYCN oncoprotein is an RNA-binding accessory factor of the nuclear exosome targeting complex. Papadopoulos D, Ha SA, Fleischhauer D, Uhl L, Russell TJ, Mikicic I, Schneider K, Brem A, Valanju OR, Cossa G, Gallant P, Schuelein-Voelk C, Maric HM, Beli P, Buchel G, Vos SM, Eilers M. Mol Cell. 2024 Jun 6;84(11):2070-2086.e20. doi: 10.1016/j.molcel.2024.04.007. Epub 2024 May 3. PubMed |
| Heat shock protein 72 supports extracellular matrix production in metastatic mammary tumors. Lang BJ, Holton KM, Guerrero-Gimenez ME, Okusha Y, Magahis PT, Shi A, Neguse M, Venkatesh S, Nhu AM, Gestwicki JE, Calderwood SK. Cell Stress Chaperones. 2024 Jun;29(3):456-471. doi: 10.1016/j.cstres.2024.04.006. Epub 2024 May 3. PubMed |
| USP20 deubiquitinates and stabilizes the reticulophagy receptor RETREG1/FAM134B to drive reticulophagy. Zhang M, Wang Z, Zhao Q, Yang Q, Bai J, Yang C, Zhang ZR, Liu Y. Autophagy. 2024 Aug;20(8):1780-1797. doi: 10.1080/15548627.2024.2347103. Epub 2024 May 12. PubMed |
| Morphological basis of the lung adenocarcinoma subtypes. Zha L, Matsu-Ura T, Sluka JP, Murakawa T, Tsuta K. iScience. 2024 Apr 12;27(5):109742. doi: 10.1016/j.isci.2024.109742. eCollection 2024 May 17. PubMed |
| ISWI chromatin remodeling complexes recruit NSD2 and H3K36me2 in pericentromeric heterochromatin. Goto N, Suke K, Yonezawa N, Nishihara H, Handa T, Sato Y, Kujirai T, Kurumizaka H, Yamagata K, Kimura H. J Cell Biol. 2024 Aug 5;223(8):e202310084. doi: 10.1083/jcb.202310084. Epub 2024 May 6. PubMed |
| The interaction of GRP78 and Zika virus E and NS1 proteins occurs in a chaperone-client manner. Sornjai W, Promma P, Priewkhiew S, Ramphan S, Jaratsittisin J, Jinagool P, Wikan N, Greenwood M, Murphy D, Smith DR. Sci Rep. 2024 May 6;14(1):10407. doi: 10.1038/s41598-024-61195-z. PubMed |
| AKAP8 promotes ovarian cancer progression and antagonizes PARP inhibitor sensitivity through regulating hnRNPUL1 transcription. Mobet Y, Wang H, Wei Q, Liu X, Yang D, Zhao H, Yang Y, Ngono Ngane RA, Souopgui J, Xu J, Liu T, Yi P. iScience. 2024 Apr 16;27(5):109744. doi: 10.1016/j.isci.2024.109744. eCollection 2024 May 17. PubMed |
| Phospholipase PLA2G7 is complementary to GPX4 in mitigating punicic-acid-induced ferroptosis in prostate cancer cells. Vermonden P, Martin M, Glowacka K, Neefs I, Ecker J, Horing M, Liebisch G, Debier C, Feron O, Larondelle Y. iScience. 2024 Apr 18;27(5):109774. doi: 10.1016/j.isci.2024.109774. eCollection 2024 May 17. PubMed |
| Functional genomics screens reveal a role for TBC1D24 and SV2B in antibody-dependent enhancement of dengue virus infection. Belmont L, Contreras M, Cartwright-Acar CH, Marceau CD, Agrawal A, Levoir LM, Lubow J, Goo L. bioRxiv [Preprint]. 2024 Apr 27:2024.04.26.591029. doi: 10.1101/2024.04.26.591029. PubMed |
| SFTSV nucleoprotein mediates DNA sensor cGAS degradation to suppress cGAS-dependent antiviral responses. Jiang Z-z, Chu M, Yan L-n, Zhang W-k, Li B, Xu J, Zhao Z-x, Han H-J, Zhou C-m, Yu X-j. Microbiol Spectr. 2024 Jun 4;12(6):e0379623. doi: 10.1128/spectrum.03796-23. Epub 2024 May 7. PubMed |
| Genomic context- and H2AK119 ubiquitination-dependent inheritance of human Polycomb silencing. Shafiq TA, Yu J, Feng W, Zhang Y, Zhou H, Paulo JA, Gygi SP, Moazed D. Sci Adv. 2024 May 10;10(19):eadl4529. doi: 10.1126/sciadv.adl4529. Epub 2024 May 8. PubMed |
| CDKN2A/B Homozygous Deletion Sensitizes IDH-Mutant Glioma to CDK4/6 Inhibition. Nasser AM, Melamed L, Wetzel EA, Chang JC, Nagashima H, Kitagawa Y, Muzyka L, Wakimoto H, Cahill DP, Miller JJ. Clin Cancer Res. 2024 Jul 15;30(14):2996-3005. doi: 10.1158/1078-0432.CCR-24-0562. PubMed |
| Direct reprogramming of fibroblasts into functional hepatocytes via CRISPRa activation of endogenous Gata4 and Foxa3. Li J, Li R, Bai X, Zhang W, Nie Y, Hu S. Chin Med J (Engl). 2024 Jun 5;137(11):1351-1359. doi: 10.1097/CM9.0000000000003088. Epub 2024 May 9. PubMed |
| Identification of WNK1 as a therapeutic target to suppress IgH/MYC expression in multiple myeloma. Ye T, Mishra AK, Banday S, Li R, Hu K, Coleman MM, Shan Y, Chowdhury SR, Zhou L, Pak ML, Simone TM, Malonia SK, Zhu LJ, Kelliher MA, Green MR. Cell Rep. 2024 May 28;43(5):114211. doi: 10.1016/j.celrep.2024.114211. Epub 2024 May 8. PubMed |
| Resf1 is a compound G4 quadruplex-associated tumor suppressor for triple negative breast cancer. Majocha MR, Jackson DE, Ha NH, Amin R, Pangracova M, Ross CR, Yang HH, Lee MP, Hunter KW. PLoS Genet. 2024 May 9;20(5):e1011236. doi: 10.1371/journal.pgen.1011236. eCollection 2024 May. PubMed |
| An ATP13A1-assisted topogenesis pathway for folding multi-spanning membrane proteins. Ji J, Cui MK, Zou R, Wu MZ, Ge MX, Li J, Zhang ZR. Mol Cell. 2024 May 16;84(10):1917-1931.e15. doi: 10.1016/j.molcel.2024.04.010. Epub 2024 May 8. PubMed |
| Activating innate immune responses repolarizes hPSC-derived CAR macrophages to improve anti-tumor activity. Shen J, Lyu S, Xu Y, Zhang S, Li L, Li J, Mou J, Xie L, Tang K, Wen W, Peng X, Yang Y, Shi Y, Li X, Wang M, Li X, Wang J, Cheng T. Cell Stem Cell. 2024 Jul 5;31(7):1003-1019.e9. doi: 10.1016/j.stem.2024.04.012. Epub 2024 May 8. PubMed |
| Network-based elucidation of colon cancer drug resistance mechanisms by phosphoproteomic time-series analysis. Rosenberger G, Li W, Turunen M, He J, Subramaniam PS, Pampou S, Griffin AT, Karan C, Kerwin P, Murray D, Honig B, Liu Y, Califano A. Nat Commun. 2024 May 9;15(1):3909. doi: 10.1038/s41467-024-47957-3. PubMed |
| The IL-6 signaling pathway contributes critically to the immunomodulatory mechanism of human decidua-derived mesenchymal stromal cells. Na H, Im KI, Kim N, Lee J, Gil S, Min GJ, Cho SG. iScience. 2024 Apr 18;27(5):109783. doi: 10.1016/j.isci.2024.109783. eCollection 2024 May 17. PubMed |
| CD133 Stimulates Cell Proliferation via the Upregulation of Amphiregulin in Melanoma. Simbulan-Rosenthal CM, Islam N, Haribabu Y, Alobaidi R, Shalamzari A, Graham G, Kuo LW, Sykora P, Rosenthal DS. Cells. 2024 May 2;13(9):777. doi: 10.3390/cells13090777. PubMed |
| TruD technology for the study of epi- and endothelial tubes in vitro. Hansen SH. PLoS One. 2024 May 10;19(5):e0301099. doi: 10.1371/journal.pone.0301099. eCollection 2024. PubMed |
| TFPI from erythroblasts drives heme production in central macrophages promoting erythropoiesis in polycythemia. Ma JK, Su LD, Feng LL, Li JL, Pan L, Danzeng Q, Li Y, Shang T, Zhan XL, Chen SY, Ying S, Hu JR, Chen XQ, Zhang Q, Liang T, Lu XJ. Nat Commun. 2024 May 10;15(1):3976. doi: 10.1038/s41467-024-48328-8. PubMed |
| SP2509, a specific antagonist of LSD1, exhibits antiviral properties against Porcine epidemic diarrhea virus. Zhao X, Zhang Y, Qu S, Tang W, He T, Li P, Zheng X. BMC Vet Res. 2024 May 10;20(1):187. doi: 10.1186/s12917-024-04052-5. PubMed |
| EGCG Disrupts the LIN28B/Let-7 Interaction and Reduces Neuroblastoma Aggressiveness. Cocchi S, Greco V, Sidarovich V, Vigna J, Broso F, Corallo D, Zasso J, Re A, Rosatti EF, Longhi S, Defant A, Ladu F, Sanna V, Adami V, D'Agostino VG, Sturlese M, Sechi M, Aveic S, Mancini I, Sighel D, Quattrone A. Int J Mol Sci. 2024 Apr 27;25(9):4795. doi: 10.3390/ijms25094795. PubMed |
| DDX18 Facilitates the Tumorigenesis of Lung Adenocarcinoma by Promoting Cell Cycle Progression through the Upregulation of CDK4. Feng B, Wang X, Qiu D, Sun H, Deng J, Tan Y, Ji K, Xu S, Zhang S, Tang C. Int J Mol Sci. 2024 May 1;25(9):4953. doi: 10.3390/ijms25094953. PubMed |
| Metabolic regulator ERRgamma governs gastric stem cell differentiation into acid-secreting parietal cells. Adkins-Threats M, Arimura S, Huang YZ, Divenko M, To S, Mao H, Zeng Y, Hwang JY, Burclaff JR, Jain S, Mills JC. Cell Stem Cell. 2024 Jun 6;31(6):886-903.e8. doi: 10.1016/j.stem.2024.04.016. Epub 2024 May 10. PubMed |
| Polymorphic residues in HLA-B that mediate HIV control distinctly modulate peptide interactions with both TCR and KIR molecules. Tano-Menka R, Singh NK, Muzhingi I, Li X, Mandanas MV, Kaseke C, Crain CR, Zhang A, Ogunshola FJ, Vecchiarello L, Piechocka-Trocha A, Bashirova A, Birnbaum ME, Carrington M, Walker BD, Gaiha GD. Structure. 2024 May 7:S0969-2126(24)00141-2. doi: 10.1016/j.str.2024.04.015. PubMed |
| Valrubicin-loaded immunoliposomes for specific vesicle-mediated cell death in the treatment of hematological cancers. Georgievski A, Bellaye PS, Tournier B, Choubley H, Pais de Barros JP, Herbst M, Beduneau A, Callier P, Collin B, Vegran F, Ballerini P, Garrido C, Quere R. Cell Death Dis. 2024 May 11;15(5):328. doi: 10.1038/s41419-024-06715-5. PubMed |
| Targeted sequencing for hereditary breast and ovarian cancer in BRCA1/2-negative families reveals complex genetic architecture and phenocopies. Plowman JN, Matoy EJ, Uppala LV, Draves SB, Watson CJ, Sefranek BA, Stacey ML, Anderson SP, Belshan MA, Blue EE, Huff CD, Fu Y, Stessman HAF. HGG Adv. 2024 Jul 18;5(3):100306. doi: 10.1016/j.xhgg.2024.100306. Epub 2024 May 10. PubMed |
| Cyclin-dependent kinase 12 deficiency reprogrammes cellular metabolism to alleviate ferroptosis potential and promote the progression of castration-resistant prostate cancer. Zhang H, Zhou Y, Feng Y, Hou W, Chen Y, Xing Z, Zhang Y, Wei Q, Yin Y, Guo J, Hu H. Clin Transl Med. 2024 May;14(5):e1678. doi: 10.1002/ctm2.1678. PubMed |
| CLEC4D as a Novel Prognostic Marker Boosts the Proliferation and Migration of Gastric Cancer via the NF-kappaB/AKT Signaling Pathway. Yang Y, Zhang M, Cai F, Ma G, Zhang RP, Yin Y, Deng J. Int J Gen Med. 2024 May 6;17:1923-1935. doi: 10.2147/IJGM.S458228. eCollection 2024. PubMed |
| Legionella pneumophila exploits the endo-lysosomal network for phagosome biogenesis by co-opting SUMOylated Rab7. Li C, Fu J, Shao S, Luo ZQ. PLoS Pathog. 2024 May 13;20(5):e1011783. doi: 10.1371/journal.ppat.1011783. eCollection 2024 May. PubMed |
| Tumors cells with mismatch repair deficiency induce hyperactivation of pyroptosis resistant to cell membrane damage but are more sensitive to co-treatment of IFN-gamma and TNF-alpha to PANoptosis. Li H, Ni H, Li Y, Zhou A, Qin X, Li Y, Che L, Mo H, Qin C, Li J. Cell Death Discov. 2024 May 13;10(1):227. doi: 10.1038/s41420-024-01984-7. PubMed |
| Cell type specific long non-coding RNA targets identified by integrative analysis of single-cell and bulk colorectal cancer transcriptomes. Mihaljevic A, Rubin PD, Chouvardas P, Esposito R. Sci Rep. 2024 May 13;14(1):10939. doi: 10.1038/s41598-024-61430-7. PubMed |
| N6-methyladenosine modification of KLF2 may contribute to endothelial-to-mesenchymal transition in pulmonary hypertension. Kang K, Xiang J, Zhang X, Xie Y, Zhou M, Zeng L, Zhuang J, Kuang J, Lin Y, Hu B, Xiong Q, Yin Q, Su Q, Liao X, Wang J, Niu Y, Liu C, Tian J, Gou D. Cell Mol Biol Lett. 2024 May 13;29(1):69. doi: 10.1186/s11658-024-00590-w. PubMed |
| Comparing chemical transfection, electroporation, and lentiviral vector transduction to achieve optimal transfection conditions in the Vero cell line. Jamour P, Jamali A, Langeroudi AG, Sharafabad BE, Abdoli A. BMC Mol Cell Biol. 2024 May 13;25(1):15. doi: 10.1186/s12860-024-00511-x. PubMed |
| ALK inhibitors suppress HCC and synergize with anti-PD-1 therapy and ABT-263 in preclinical models. Bugide S, Reddy DS, Malvi P, Gupta R, Wajapeyee N. iScience. 2024 Apr 23;27(5):109800. doi: 10.1016/j.isci.2024.109800. eCollection 2024 May 17. PubMed |
| FBXO22 is a potential therapeutic target for recurrent chondrosarcoma. Xin B, Chen H, Zhu Z, Guan Q, Bai G, Yang C, Zou W, Gao X, Li L, Liu T. J Bone Oncol. 2024 May 1;46:100605. doi: 10.1016/j.jbo.2024.100605. eCollection 2024 Jun. PubMed |
| Genome-wide CRISPR screens in spheroid culture reveal that the tumor suppressor LKB1 inhibits growth via the PIKFYVE lipid kinase. Ferrarone JR, Thomas J, Unni AM, Zheng Y, Nagiec MJ, Gardner EE, Mashadova O, Li K, Koundouros N, Montalbano A, Mustafa M, Cantley LC, Blenis J, Sanjana NE, Varmus H. Proc Natl Acad Sci U S A. 2024 May 21;121(21):e2403685121. doi: 10.1073/pnas.2403685121. Epub 2024 May 14. PubMed |
| mTORC1 regulates cell survival under glucose starvation through 4EBP1/2-mediated translational reprogramming of fatty acid metabolism. Levy T, Voeltzke K, Hruby L, Alasad K, Bas Z, Snaebjornsson M, Marciano R, Scharov K, Planque M, Vriens K, Christen S, Funk CM, Hassiepen C, Kahler A, Heider B, Picard D, Lim JKM, Stefanski A, Bendrin K, Vargas-Toscano A, Kahlert UD, Stuhler K, Remke M, Elkabets M, Grunewald TGP, Reichert AS, Fendt SM, Schulze A, Reifenberger G, Rotblat B, Leprivier G. Nat Commun. 2024 May 14;15(1):4083. doi: 10.1038/s41467-024-48386-y. PubMed |
| Conserved role of hnRNPL in alternative splicing of epigenetic modifiers enables B cell activation. Subramani PG, Fraszczak J, Helness A, Estall JL, Moroy T, Di Noia JM. EMBO Rep. 2024 Jun;25(6):2662-2697. doi: 10.1038/s44319-024-00152-3. Epub 2024 May 14. PubMed |
| PSMD9 promotes the malignant progression of hepatocellular carcinoma by interacting with c-Cbl to activate EGFR signaling and recycling. Su Y, Meng L, Ge C, Liu Y, Zhang C, Yang Y, Tian W, Tian H. J Exp Clin Cancer Res. 2024 May 14;43(1):142. doi: 10.1186/s13046-024-03062-3. PubMed |
CRISPR-Cas13d screens identify KILR, a breast cancer risk-associated lncRNA that regulates DNA replication and repair.
Wang L, Bitar M, Lu X, Jacquelin S, Nair S, Sivakumaran H, Hillman KM, Kaufmann S, Ziegman R, Casciello F, Gowda H, Rosenbluh J, Edwards SL, French JD.
Mol Cancer. 2024 May 15;23(1):101. doi: 10.1186/s12943-024-02021-y.
PubMed
Associated Plasmids |
| PAX6 promotes neuroendocrine phenotypes of prostate cancer via enhancing MET/STAT5A-mediated chromatin accessibility. Jing N, Du X, Liang Y, Tao Z, Bao S, Xiao H, Dong B, Gao WQ, Fang YX. J Exp Clin Cancer Res. 2024 May 15;43(1):144. doi: 10.1186/s13046-024-03064-1. PubMed |
| CD38 restrains the activity of extracellular cGAMP in a model of multiple myeloma. Cuollo L, Di Cristofano S, Sandomenico A, Iaccarino E, Oliver A, Zingoni A, Cippitelli M, Fionda C, Petillo S, Kosta A, Tassinari V, Petrucci MT, Fazio F, Ruvo M, Santoni A, Raimondo D, Soriani A. iScience. 2024 Apr 25;27(5):109814. doi: 10.1016/j.isci.2024.109814. eCollection 2024 May 17. PubMed |
| PCDH17 restricts dendritic spine morphogenesis by regulating ROCK2-dependent control of the actin cytoskeleton, modulating emotional behavior. Yu L, Zeng F, Fan M, Zhang K, Duan J, Tan Y, Liao P, Wen J, Wang C, Wang M, Yuan J, Pang X, Huang Y, Zhang Y, Li JD, Zhang Z, Hu Z. Zool Res. 2024 May 18;45(3):535-550. doi: 10.24272/j.issn.2095-8137.2024.055. PubMed |
| Oncogene EVI1 drives acute myeloid leukemia via a targetable interaction with CTBP2. Pastoors D, Havermans M, Mulet-Lazaro R, Brian D, Noort W, Grasel J, Hoogenboezem R, Smeenk L, Demmers JAA, Milsom MD, Enver T, Groen RWJ, Bindels E, Delwel R. Sci Adv. 2024 May 17;10(20):eadk9076. doi: 10.1126/sciadv.adk9076. Epub 2024 May 15. PubMed |
| HPV16-miRNAs exert oncogenic effects through enhancers in human cervical cancer. Wang Y, Wang X, Liu Y, He Y, Duan X, Li Q, Huang Y, Xu G, Lu Q. Cancer Cell Int. 2024 May 15;24(1):172. doi: 10.1186/s12935-024-03364-8. PubMed |
| linc-ADAIN, a human adipose lincRNA, regulates adipogenesis by modulating KLF5 and IL-8 mRNA stability. O'Reilly ME, Ho S, Coronel J, Zhu L, Liu W, Xue C, Kim E, Cynn E, Matias CV, Soni RK, Wang C, Ionita-Laza I, Bauer RC, Ross L, Zhang Y, Corvera S, Fried SK, Reilly MP. Cell Rep. 2024 May 28;43(5):114240. doi: 10.1016/j.celrep.2024.114240. Epub 2024 May 14. PubMed |
| CXCL16-dependent scavenging of oxidized lipids by islet macrophages promotes differentiation of pathogenic CD8(+) T cells in diabetic autoimmunity. Srivastava N, Hu H, Peterson OJ, Vomund AN, Stremska M, Zaman M, Giri S, Li T, Lichti CF, Zakharov PN, Zhang B, Abumrad NA, Chen YG, Ravichandran KS, Unanue ER, Wan X. Immunity. 2024 Jul 9;57(7):1629-1647.e8. doi: 10.1016/j.immuni.2024.04.017. Epub 2024 May 15. PubMed |
| Endocardial HDAC3 is required for myocardial trabeculation. Jang J, Bentsen M, Kim YJ, Kim E, Garg V, Cai CL, Looso M, Li D. Nat Commun. 2024 May 16;15(1):4166. doi: 10.1038/s41467-024-48362-6. PubMed |
| Downregulation of HNF4A enables transcriptomic reprogramming during the hepatic acute-phase response. Ehle C, Iyer-Bierhoff A, Wu Y, Xing S, Kiehntopf M, Mosig AS, Godmann M, Heinzel T. Commun Biol. 2024 May 16;7(1):589. doi: 10.1038/s42003-024-06288-1. PubMed |
| Nanobody-based CAR NK cells for possible immunotherapy of MICA(+) tumors. Verhaar ER, van Keizerswaard WJC, Knoflook A, Balligand T, Ploegh HL. PNAS Nexus. 2024 May 6;3(5):pgae184. doi: 10.1093/pnasnexus/pgae184. eCollection 2024 May. PubMed |
| Somatic structural variants drive distinct modes of oncogenesis in melanoma. Conway JR, Gillani R, Crowdis J, Reardon B, Park J, Han S, Titchen B, Benamar M, Haq R, Van Allen EM. J Clin Invest. 2024 May 14;134(13):e177270. doi: 10.1172/JCI177270. PubMed |
| Non-canonical substrate recognition by the human WDR26-CTLH E3 ligase regulates prodrug metabolism. Gottemukkala KV, Chrustowicz J, Sherpa D, Sepic S, Vu DT, Karayel O, Papadopoulou EC, Gross A, Schorpp K, von Gronau S, Hadian K, Murray PJ, Mann M, Schulman BA, Alpi AF. Mol Cell. 2024 May 16;84(10):1948-1963.e11. doi: 10.1016/j.molcel.2024.04.014. PubMed |
| Unraveling ETC complex I function in ferroptosis reveals a potential ferroptosis-inducing therapeutic strategy for LKB1-deficient cancers. Mao C, Lei G, Horbath A, Wang M, Lu Z, Yan Y, Liu X, Kondiparthi L, Chen X, Cheng J, Li Q, Xu Z, Zhuang L, Fang B, Marszalek JR, Poyurovsky MV, Olszewski K, Gan B. Mol Cell. 2024 May 16;84(10):1964-1979.e6. doi: 10.1016/j.molcel.2024.04.009. PubMed |
| Inhibitors of dermatan sulfate epimerase 1 decreased accumulation of glycosaminoglycans in mucopolysaccharidosis type I fibroblasts. Maccarana M, Li B, Li H, Fang J, Yu M, Li JP. Glycobiology. 2024 Apr 24;34(6):cwae025. doi: 10.1093/glycob/cwae025. PubMed |
| The increase of long noncoding RNA Fendrr in hepatocytes contributes to liver fibrosis by promoting IL-6 production. Kang Z, Wang C, Shao F, Deng H, Sun Y, Ren Z, Zhang W, Ding Z, Zhang J, Zang Y. J Biol Chem. 2024 Jun;300(6):107376. doi: 10.1016/j.jbc.2024.107376. Epub 2024 May 16. PubMed |
| Testis-specific serine kinase 6 (TSSK6) is abnormally expressed in colorectal cancer and promotes oncogenic behaviors. Delgado M, Gallegos Z, Stippec S, McGlynn K, Cobb MH, Whitehurst AW. J Biol Chem. 2024 Jun;300(6):107380. doi: 10.1016/j.jbc.2024.107380. Epub 2024 May 16. PubMed |
| Novel markers of MCL1 inhibitor sensitivity in triple-negative breast cancer cells. Duan L, Tadi MJ, O'Hara KM, Maki CG. J Biol Chem. 2024 Jun;300(6):107375. doi: 10.1016/j.jbc.2024.107375. Epub 2024 May 16. PubMed |
| Post-translational digital data encoding into the genomes of mammalian cell populations. Callisto A, Strutz J, Leeper K, Kalhor R, Church G, Tyo KEJ, Bhan N. bioRxiv [Preprint]. 2024 Dec 9:2024.05.12.591851. doi: 10.1101/2024.05.12.591851. PubMed |
| Context dependent activity of p63-bound gene regulatory elements. McCann AA, Baniulyte G, Woodstock DL, Sammons MA. bioRxiv [Preprint]. 2024 May 12:2024.05.09.593326. doi: 10.1101/2024.05.09.593326. PubMed |
| Daily glucocorticoids promote glioblastoma growth and circadian synchrony to the host. Gonzalez-Aponte MF, Damato AR, Simon T, Aripova N, Darby F, Rubin JB, Herzog ED. bioRxiv [Preprint]. 2024 May 6:2024.05.03.592418. doi: 10.1101/2024.05.03.592418. PubMed |
Pseudotyped virus infection of multiplexed ACE2 libraries reveals SARS-CoV-2 variant shifts in receptor usage.
Shukla N, Roelle SM, Snell JC, DelSignore O, Bruchez AM, Matreyek KA.
PLoS Pathog. 2024 May 20;20(5):e1012044. doi: 10.1371/journal.ppat.1012044.
PubMed
Associated Plasmids |
| Deprivation of methionine inhibits osteosarcoma growth and metastasis via C1orf112-mediated regulation of mitochondrial functions. Zhang X, Zhao Z, Wang X, Zhang S, Zhao Z, Feng W, Xu L, Nie J, Li H, Liu J, Xiao G, Zhang Y, Li H, Lu M, Mai J, Zhou S, Zhao AZ, Li F. Cell Death Dis. 2024 May 20;15(5):349. doi: 10.1038/s41419-024-06727-1. PubMed |
| Targeting c-Myc transactivation by LMNA inhibits tRNA processing essential for malate-aspartate shuttle and tumour progression. Wang J, Hong M, Cheng Y, Wang X, Li D, Chen G, Bao B, Song J, Du X, Yang C, Zheng L, Tong Q. Clin Transl Med. 2024 May;14(5):e1680. doi: 10.1002/ctm2.1680. PubMed |
| Oncogenic fatty acid oxidation senses circadian disruption in sleep-deficiency-enhanced tumorigenesis. Peng F, Lu J, Su K, Liu X, Luo H, He B, Wang C, Zhang X, An F, Lv D, Luo Y, Su Q, Jiang T, Deng Z, He B, Xu L, Guo T, Xiang J, Gu C, Wang L, Xu G, Xu Y, Li M, Kelley KW, Cui B, Liu Q. Cell Metab. 2024 Jul 2;36(7):1598-1618.e11. doi: 10.1016/j.cmet.2024.04.018. Epub 2024 May 20. PubMed |
| SDHAF1 confers metabolic resilience to aging hematopoietic stem cells by promoting mitochondrial ATP production. Watanuki S, Kobayashi H, Sugiura Y, Yamamoto M, Karigane D, Shiroshita K, Sorimachi Y, Morikawa T, Fujita S, Shide K, Haraguchi M, Tamaki S, Mikawa T, Kondoh H, Nakano H, Sumiyama K, Nagamatsu G, Goda N, Okamoto S, Nakamura-Ishizu A, Shimoda K, Suematsu M, Suda T, Takubo K. Cell Stem Cell. 2024 Aug 1;31(8):1145-1161.e15. doi: 10.1016/j.stem.2024.04.023. Epub 2024 May 20. PubMed |
| Priming with LSD1 inhibitors promotes the persistence and antitumor effect of adoptively transferred T cells. Qiu F, Jiang P, Zhang G, An J, Ruan K, Lyu X, Zhou J, Sheng W. Nat Commun. 2024 May 21;15(1):4327. doi: 10.1038/s41467-024-48607-4. PubMed |
| FBXO42 activity is required to prevent mitotic arrest, spindle assembly checkpoint activation and lethality in glioblastoma and other cancers. Hoellerbauer P, Kufeld M, Arora S, Mitchell K, Girard EJ, Herman JA, Olson JM, Paddison PJ. NAR Cancer. 2024 May 20;6(2):zcae021. doi: 10.1093/narcan/zcae021. eCollection 2024 Jun. PubMed |
| The beta-arrestin1/endothelin axis bolsters ovarian fibroblast-dependent invadosome activity and cancer cell metastatic potential. Del Rio D, Masi I, Caprara V, Ottavi F, Albertini Petroni G, Salvati E, Trisciuoglio D, Giannitelli SM, Bagnato A, Mauri E, Spadaro F, Rosano L. Cell Death Dis. 2024 May 22;15(5):358. doi: 10.1038/s41419-024-06730-6. PubMed |
| Opportunistic pathogen Porphyromonas gingivalis targets the LC3B-ceramide complex and mediates lethal mitophagy resistance in oral tumors. Sheridan M, Chowdhury N, Wellslager B, Oleinik N, Kassir MF, Lee HG, Engevik M, Peterson Y, Pandruvada S, Szulc ZM, Yilmaz O, Ogretmen B. iScience. 2024 Apr 30;27(6):109860. doi: 10.1016/j.isci.2024.109860. eCollection 2024 Jun 21. PubMed |
| PKMYT1 Is a Marker of Treatment Response and a Therapeutic Target for CDK4/6 Inhibitor-Resistance in ER+ Breast Cancer. Chen A, Kim BJ, Mitra A, Vollert CT, Lei JT, Fandino D, Anurag M, Holt MV, Gou X, Pilcher JB, Goetz MP, Northfelt DW, Hilsenbeck SG, Marshall CG, Hyer ML, Papp R, Yin SY, De Angelis C, Schiff R, Fuqua SAW, Ma CX, Foulds CE, Ellis MJ. Mol Cancer Ther. 2024 Oct 1;23(10):1494-1510. doi: 10.1158/1535-7163.MCT-23-0564. PubMed |
| CRISPRi screens identify the lncRNA, LOUP, as a multifunctional locus regulating macrophage differentiation and inflammatory signaling. Halasz H, Malekos E, Covarrubias S, Yitiz S, Montano C, Sudek L, Katzman S, Liu SJ, Horlbeck MA, Namvar L, Weissman JS, Carpenter S. Proc Natl Acad Sci U S A. 2024 May 28;121(22):e2322524121. doi: 10.1073/pnas.2322524121. Epub 2024 May 23. PubMed |
| A synthetic lethal dependency on casein kinase 2 in response to replication-perturbing therapeutics in RB1-deficient cancer cells. Bulanova D, Akimov Y, Senkowski W, Oikkonen J, Gall-Mas L, Timonen S, Elmadani M, Hynninen J, Hautaniemi S, Aittokallio T, Wennerberg K. Sci Adv. 2024 May 24;10(21):eadj1564. doi: 10.1126/sciadv.adj1564. Epub 2024 May 23. PubMed |
| Vaccination with nanoparticles displaying gH/gL from Epstein-Barr virus elicits limited cross-protection against rhesus lymphocryptovirus. Edwards KR, Schmidt K, Homad LJ, Kher GM, Xu G, Rodrigues KA, Ben-Akiva E, Abbott J, Prlic M, Newell EW, De Rosa SC, Irvine DJ, Pancera M, McGuire AT. Cell Rep Med. 2024 Jun 18;5(6):101587. doi: 10.1016/j.xcrm.2024.101587. Epub 2024 May 22. PubMed |
| Glial fibrillary acidic protein is pathologically modified in Alexander disease. Lin NH, Jian WS, Snider N, Perng MD. J Biol Chem. 2024 Jul;300(7):107402. doi: 10.1016/j.jbc.2024.107402. Epub 2024 May 21. PubMed |
| The tardigrade-derived mitochondrial abundant heat soluble protein improves adipose-derived stem cell survival against representative stressors. Rolsma JL, Darch W, Higgins NC, Morgan JT. Sci Rep. 2024 May 23;14(1):11834. doi: 10.1038/s41598-024-62693-w. PubMed |
| LncRNA IRAIN overcomes imatinib resistance in chronic myeloid leukemia via NF-kappaB/CD44 pathway inhibition. Wang X, Hou Y, Lyu Y, Zhou J, Zhang X, Hassani MA, Huang D, Zhao Z, Zhou D, Xie F, Zhang X, Yan J. iScience. 2024 Apr 30;27(6):109851. doi: 10.1016/j.isci.2024.109851. eCollection 2024 Jun 21. PubMed |
| Exogenous Metabolic Modulators Improve Response to Carboplatin in Triple-Negative Breast Cancer. Ho AN, Kiesel VA, Gates CE, Brosnan BH, Connelly SP, Glenny EM, Cozzo AJ, Hursting SD, Coleman MF. Cells. 2024 May 9;13(10):806. doi: 10.3390/cells13100806. PubMed |
| A RIPK1-specific PROTAC degrader achieves potent antitumor activity by enhancing immunogenic cell death. Mannion J, Gifford V, Bellenie B, Fernando W, Ramos Garcia L, Wilson R, John SW, Udainiya S, Patin EC, Tiu C, Smith A, Goicoechea M, Craxton A, Moraes de Vasconcelos N, Guppy N, Cheung KJ, Cundy NJ, Pierrat O, Brennan A, Roumeliotis TI, Benstead-Hume G, Alexander J, Muirhead G, Layzell S, Lyu W, Roulstone V, Allen M, Baldock H, Legrand A, Gabel F, Serrano-Aparicio N, Starling C, Guo H, Upton J, Gyrd-Hansen M, MacFarlane M, Seddon B, Raynaud F, Roxanis I, Harrington K, Haider S, Choudhary JS, Hoelder S, Tenev T, Meier P. Immunity. 2024 Jul 9;57(7):1514-1532.e15. doi: 10.1016/j.immuni.2024.04.025. Epub 2024 May 23. PubMed |
| CXCL8 Knockout: A Key to Resisting Pasteurella multocida Toxin-Induced Cytotoxicity. Yuan J, Zhao Q, Li J, Wen Y, Wu R, Zhao S, Lang YF, Yan QG, Huang X, Du S, Cao SJ. Int J Mol Sci. 2024 May 14;25(10):5330. doi: 10.3390/ijms25105330. PubMed |
| Identification of an Immunodominant B-Cell Epitope in African Swine Fever Virus p30 Protein and Evidence of p30 Antibody-Mediated Antibody Dependent Cellular Cytotoxicity. Noll JCG, Rani R, Butt SL, Fernandes MHV, do Nascimento GM, Martins M, Caserta LC, Covaleda L, Diel DG. Viruses. 2024 May 10;16(5):758. doi: 10.3390/v16050758. PubMed |
| Modulation of Paracellular Permeability in SARS-CoV-2 Blood-to-Brain Transcytosis. Martinez TE, Mayilsamy K, Mohapatra SS, Mohapatra S. Viruses. 2024 May 15;16(5):785. doi: 10.3390/v16050785. PubMed |
| In vitro assessment of thyroid peroxidase inhibition by chemical exposure: comparison of cell models and detection methods. Liu R, Novak J, Hilscherova K. Arch Toxicol. 2024 Aug;98(8):2631-2645. doi: 10.1007/s00204-024-03766-7. Epub 2024 May 25. PubMed |
| CRACD loss induces neuroendocrine cell plasticity of lung adenocarcinoma. Kim B, Zhang S, Huang Y, Ko KP, Jung YS, Jang J, Zou G, Zhang J, Jun S, Kim KB, Park KS, Park JI. Cell Rep. 2024 Jun 25;43(6):114286. doi: 10.1016/j.celrep.2024.114286. Epub 2024 May 25. PubMed |
| Identification and Pharmacological Targeting of Treatment-Resistant, Stem-like Breast Cancer Cells for Combination Therapy. Worley J, Noh H, You D, Turunen MM, Ding H, Paull E, Griffin AT, Grunn A, Zhang M, Guillan K, Bush EC, Brosius SJ, Hibshoosh H, Mundi PS, Sims P, Dalerba P, Dela Cruz FS, Kung AL, Califano A. bioRxiv [Preprint]. 2024 May 16:2023.11.08.562798. doi: 10.1101/2023.11.08.562798. PubMed |
| TERC promotes non-small cell lung cancer progression by facilitating the nuclear localization of TERT. Sun H, Li X, Long Q, Wang X, Zhu W, Chen E, Zhou W, Yang H, Huang C, Deng W, Chen M. iScience. 2024 May 3;27(6):109869. doi: 10.1016/j.isci.2024.109869. eCollection 2024 Jun 21. PubMed |
| Small molecule conjugates with selective estrogen receptor beta agonism promote anti-aging benefits in metabolism and skin recovery. Zahr T, Boda VK, Ge J, Yu L, Wu Z, Que J, Li W, Qiang L. Acta Pharm Sin B. 2024 May;14(5):2137-2152. doi: 10.1016/j.apsb.2024.01.014. Epub 2024 Jan 29. PubMed |
| A fluorescence-based sensor for calibrated measurement of protein kinase stability in live cells. Paul JW 3rd, Muratcioglu S, Kuriyan J. Protein Sci. 2024 Jun;33(6):e5023. doi: 10.1002/pro.5023. PubMed |
| Proximal protein landscapes of the type I interferon signaling cascade reveal negative regulation by PJA2. Schiefer S, Hale BG. Nat Commun. 2024 May 27;15(1):4484. doi: 10.1038/s41467-024-48800-5. PubMed |
| CircPIAS1 promotes hepatocellular carcinoma progression by inhibiting ferroptosis via the miR-455-3p/NUPR1/FTH1 axis. Zhang XY, Li SS, Gu YR, Xiao LX, Ma XY, Chen XR, Wang JL, Liao CH, Lin BL, Huang YH, Lian YF. Mol Cancer. 2024 May 28;23(1):113. doi: 10.1186/s12943-024-02030-x. PubMed |
| Ferredoxin 1: a gatekeeper in halting lung adenocarcinoma progression through activation of the GPRIN2 signaling pathway. Liu M, Wu S, Wu H, Zhou Y, Zhang X, Zhu D, Jiang J. J Transl Med. 2024 May 27;22(1):510. doi: 10.1186/s12967-024-05277-6. PubMed |
| CCR5-overexpressing mesenchymal stem cells protect against experimental autoimmune uveitis: insights from single-cell transcriptome analysis. Yuan F, Zhang R, Li J, Lei Q, Wang S, Jiang F, Guo Y, Xiang M. J Neuroinflammation. 2024 May 27;21(1):136. doi: 10.1186/s12974-024-03134-3. PubMed |
| Identification of a Fully Human Antibody VH Domain Targeting Anaplastic Lymphoma Kinase (ALK) with Applications in ALK-Positive Solid Tumor Immunotherapy. Chen C, Sun Z, Wang Z, Shin S, Berrios A, Mellors JW, Dimitrov DS, Li W. Antibodies (Basel). 2024 May 7;13(2):39. doi: 10.3390/antib13020039. PubMed |
| FOXA3 regulates cholesterol metabolism to compensate for low uptake during the progression of lung adenocarcinoma. Wang D, Cao Y, Meng M, Qiu J, Ni C, Guo X, Li Y, Liu S, Yu J, Guo M, Wang J, Du B, Qiu W, Xie C, Zhao B, Ma X, Cheng X, Xu L. PLoS Biol. 2024 May 28;22(5):e3002621. doi: 10.1371/journal.pbio.3002621. eCollection 2024 May. PubMed |
| Her2 amplification, Rel-A, and Bach1 can influence APOBEC3A expression in breast cancer cells. Dennis M, Hurley A, Bray N, Cordero C, Ilagan J, Mertz TM, Roberts SA. PLoS Genet. 2024 May 28;20(5):e1011293. doi: 10.1371/journal.pgen.1011293. eCollection 2024 May. PubMed |
| An essential role for EROS in redox-dependent endothelial signal transduction. Waldeck-Weiermair M, Das AA, Covington TA, Yadav S, Kaynert J, Guo R, Balendran P, Thulabandu VR, Pandey AK, Spyropoulos F, Thomas DC, Michel T. Redox Biol. 2024 Jul;73:103214. doi: 10.1016/j.redox.2024.103214. Epub 2024 May 24. PubMed |
| Pseudorabies virus hijacks the Rab6 protein to promote viral assembly and egress. Liang DG, Guo YK, Zhao SB, Yang GY, Han YQ, Chu BB, Ming SL. Vet Res. 2024 May 28;55(1):68. doi: 10.1186/s13567-024-01328-4. PubMed |
| ePRINT: exonuclease assisted mapping of protein-RNA interactions. Hawkins S, Mondaini A, Namboori SC, Nguyen GG, Yeo GW, Javed A, Bhinge A. Genome Biol. 2024 May 28;25(1):140. doi: 10.1186/s13059-024-03271-1. PubMed |
| Selective regulation of chemosensitivity in glioblastoma by phosphatidylinositol 3-kinase beta. Pridham KJ, Hutchings KR, Beck P, Liu M, Xu E, Saechin E, Bui V, Patel C, Solis J, Huang L, Tegge A, Kelly DF, Sheng Z. iScience. 2024 May 7;27(6):109921. doi: 10.1016/j.isci.2024.109921. eCollection 2024 Jun 21. PubMed |
| Carboplatin restricts peste des petits ruminants virus replication by suppressing the STING-mediated autophagy. Zhang R, Hu Z, Wei D, Li R, Li Y, Zhang Z. Front Vet Sci. 2024 May 15;11:1383927. doi: 10.3389/fvets.2024.1383927. eCollection 2024. PubMed |
| Proteolytic cleavage and inactivation of the TRMT1 tRNA modification enzyme by SARS-CoV-2 main protease. Zhang K, Eldin P, Ciesla JH, Briant L, Lentini JM, Ramos J, Cobb J, Munger J, Fu D. Elife. 2024 May 30;12:RP90316. doi: 10.7554/eLife.90316. PubMed |
| TBK1 is ubiquitinated by TRIM5alpha to assemble mitophagy machinery. Saha B, Olsvik H, Williams GL, Oh S, Evjen G, Sjottem E, Mandell MA. Cell Rep. 2024 Jun 25;43(6):114294. doi: 10.1016/j.celrep.2024.114294. Epub 2024 May 29. PubMed |
| TMPRSS2-mediated SARS-CoV-2 uptake boosts innate immune activation, enhances cytopathology, and drives convergent virus evolution. Qu B, Miskey C, Gomer A, Kleinert RDV, Ibanez SC, Eberle R, Ebenig A, Postmus D, Nocke MK, Herrmann M, Itotia TK, Herrmann ST, Heinen N, Hock S, Hastert FD, von Rhein C, Schurmann C, Li X, van Zandbergen G, Widera M, Ciesek S, Schnierle BS, Tarr AW, Steinmann E, Goffinet C, Pfaender S, Locker JK, Muhlebach MD, Todt D, Brown RJP. Proc Natl Acad Sci U S A. 2024 Jun 4;121(23):e2407437121. doi: 10.1073/pnas.2407437121. Epub 2024 May 30. PubMed |
| Epithelial aPKC deficiency leads to stem cell loss preceding metaplasia in colorectal cancer initiation. Kinoshita H, Martinez-Ordonez A, Cid-Diaz T, Han Q, Duran A, Muta Y, Zhang X, Linares JF, Nakanishi Y, Kasashima H, Yashiro M, Maeda K, Albaladejo-Gonzalez A, Torres-Moreno D, Garcia-Solano J, Conesa-Zamora P, Inghirami G, Diaz-Meco MT, Moscat J. Dev Cell. 2024 May 23:S1534-5807(24)00299-5. doi: 10.1016/j.devcel.2024.05.001. PubMed |
| ZFYVE19 deficiency: a ciliopathy involving failure of cell division, with cell death. Yang J, Zhang YN, Wang RX, Hao CZ, Qiu Y, Chi H, Luan WS, Tang H, Zhang XJ, Sun X, Sheps JA, Ling V, Cao M, Wang JS. J Med Genet. 2024 Jul 19;61(8):750-758. doi: 10.1136/jmg-2023-109779. PubMed |
| Precise correction of a spectrum of beta-thalassemia mutations in coding and non-coding regions by base editors. Prasad K, Devaraju N, George A, Ravi NS, Paul J, Mahalingam G, Rajendiran V, Panigrahi L, Venkatesan V, Lakhotiya K, Periyasami Y, Pai AA, Nakamura Y, Kurita R, Balasubramanian P, Thangavel S, Velayudhan SR, Newby GA, Marepally S, Srivastava A, Mohankumar KM. Mol Ther Nucleic Acids. 2024 May 3;35(2):102205. doi: 10.1016/j.omtn.2024.102205. eCollection 2024 Jun 11. PubMed |
| A pseudoautosomal glycosylation disorder prompts the revision of dolichol biosynthesis. Wilson MP, Kentache T, Althoff CR, Schulz C, de Bettignies G, Mateu Cabrera G, Cimbalistiene L, Burnyte B, Yoon G, Costain G, Vuillaumier-Barrot S, Cheillan D, Rymen D, Rychtarova L, Hansikova H, Bury M, Dewulf JP, Caligiore F, Jaeken J, Cantagrel V, Van Schaftingen E, Matthijs G, Foulquier F, Bommer GT. Cell. 2024 Jul 11;187(14):3585-3601.e22. doi: 10.1016/j.cell.2024.04.041. Epub 2024 May 30. PubMed |
| FGD5 in basal cells induces CXCL14 secretion that initiates a feedback loop to promote murine mammary epithelial growth and differentiation. Zhang T, Zhao C, Li Y, Wu J, Wang F, Yu J, Wang Z, Gao Y, Zhao L, Liu Y, Yan Y, Li X, Gao H, Hu Z, Cui B, Li K. Dev Cell. 2024 May 25:S1534-5807(24)00324-1. doi: 10.1016/j.devcel.2024.05.007. PubMed |
| Targeting MYC effector functions in pancreatic cancer by inhibiting the ATPase RUVBL1/2. Vogt M, Dudvarski Stankovic N, Cruz Garcia Y, Hofstetter J, Schneider K, Kuybu F, Hauck T, Adhikari B, Hamann A, Rocca Y, Grysczyk L, Martin B, Gebhardt-Wolf A, Wiegering A, Diefenbacher M, Gasteiger G, Knapp S, Saur D, Eilers M, Rosenfeldt M, Erhard F, Vos SM, Wolf E. Gut. 2024 Aug 8;73(9):1509-1528. doi: 10.1136/gutjnl-2023-331519. PubMed |
| ZDHHC20-mediated S-palmitoylation of YTHDF3 stabilizes MYC mRNA to promote pancreatic cancer progression. Zhang H, Sun Y, Wang Z, Huang X, Tang L, Jiang K, Jin X. Nat Commun. 2024 May 31;15(1):4642. doi: 10.1038/s41467-024-49105-3. PubMed |
| Regulation of TSC2 lysosome translocation and mitochondrial turnover by TSC2 acetylation status. Marques P, Burillo J, Gonzalez-Blanco C, Jimenez B, Garcia G, Garcia-Aguilar A, Iglesias-Fortes S, Lockwood A, Guillen C. Sci Rep. 2024 May 31;14(1):12521. doi: 10.1038/s41598-024-63525-7. PubMed |
| STIL facilitates the development and malignant progression of triple-negative breast cancer through activation of Fanconi anemia pathway via interacting with KLF16. Wang M, Pan B, Hu Y, Gao J, Hou L, Yu Z, Li M, Zhao Z. Transl Oncol. 2024 Aug;46:102010. doi: 10.1016/j.tranon.2024.102010. Epub 2024 May 31. PubMed |
| Area postrema neurons mediate interleukin-6 function in cancer cachexia. Sun Q, van de Lisdonk D, Ferrer M, Gegenhuber B, Wu M, Park Y, Tuveson DA, Tollkuhn J, Janowitz T, Li B. Nat Commun. 2024 Jun 1;15(1):4682. doi: 10.1038/s41467-024-48971-1. PubMed |
| Galectin-3-Binding Protein Inhibits Extracellular Heparan 6-O-Endosulfatase Sulf-2. Panigrahi A, Benicky J, Aljuhani R, Mukherjee P, Novakova Z, Barinka C, Goldman R. Mol Cell Proteomics. 2024 Jul;23(7):100793. doi: 10.1016/j.mcpro.2024.100793. Epub 2024 Jun 1. PubMed |
| Polyomavirus ALTOs, but not MTs, downregulate viral early gene expression by activating the NF-kappaB pathway. Salisbury NJH, Amonkar S, Vinueza JL, Carter JJ, Roman A, Galloway DA. bioRxiv [Preprint]. 2024 May 25:2024.05.24.595774. doi: 10.1101/2024.05.24.595774. PubMed |
| Absence of c-Maf and IL-10 enables Type I IFN enhancement of innate responses to low-dose LPS in alveolar macrophages. Lim PN, Cervantes MM, Pham LK, Doherty S, Tufts A, Dubey D, Mai D, Aderem A, Diercks AH, Rothchild AC. bioRxiv [Preprint]. 2024 May 26:2024.05.22.594428. doi: 10.1101/2024.05.22.594428. PubMed |
| A genome-scale screen identifies sulfated glycosaminoglycans as pivotal in epithelial cell damage by Candida albicans. Lin J, Miao J, Schaefer KG, Russell CM, Pyron RJ, Zhang F, Phan QT, Solis-Swidergall NV, Liu H, Tashiro M, Dordick JS, Linhardt RJ, Yeaman MR, King GM, Barrera FN, Peters BM, Filler SG. bioRxiv [Preprint]. 2024 May 23:2024.05.23.595417. doi: 10.1101/2024.05.23.595417. PubMed |
| Hippo-PKCzeta-NFkappaB signaling axis: A druggable modulator of chondrocyte responses to mechanical stress. Cai X, Warburton C, Perez OF, Wang Y, Ho L, Finelli C, Ehlen QT, Wu C, Rodriguez CD, Kaplan L, Best TM, Huang CY, Meng Z. iScience. 2024 May 15;27(6):109983. doi: 10.1016/j.isci.2024.109983. eCollection 2024 Jun 21. PubMed |
Crosstalk between Regnase-1 and -3 shapes mast cell survival and cytokine expression.
Bataclan M, Leoni C, Moro SG, Pecoraro M, Wong EH, Heissmeyer V, Monticelli S.
Life Sci Alliance. 2024 Jun 3;7(8):e202402784. doi: 10.26508/lsa.202402784. Print 2024 Aug.
PubMed
Associated Plasmids |
| PPIA dictates NRF2 stability to promote lung cancer progression. Lu W, Cui J, Wang W, Hu Q, Xue Y, Liu X, Gong T, Lu Y, Ma H, Yang X, Feng B, Wang Q, Zhang N, Xu Y, Liu M, Nussinov R, Cheng F, Ji H, Huang J. Nat Commun. 2024 Jun 3;15(1):4703. doi: 10.1038/s41467-024-48364-4. PubMed |
| The small tumor antigen of Merkel cell polyomavirus accomplishes cellular transformation by uniquely localizing to the nucleus despite the absence of a known nuclear localization signal. Thevenin KR, Tieche IS, Di Benedetto CE, Schrager M, Dye KN. Virol J. 2024 Jun 3;21(1):125. doi: 10.1186/s12985-024-02395-x. PubMed |
| Identification of an HLA-A*11:01-restricted neoepitope of mutant PIK3CA and its specific T cell receptors for cancer immunotherapy targeting hotspot driver mutations. Shen M, Chen S, Han X, Hao Y, Wang J, Li L, Chen T, Wang B, Zou L, Zhang T, Zhang W, Han X, Wang W, Yu H, Li K, Liu S, Jin A. Cancer Immunol Immunother. 2024 Jun 4;73(8):150. doi: 10.1007/s00262-024-03729-y. PubMed |
| Cancer-specific epigenome identifies oncogenic hijacking by nuclear factor I family proteins for medulloblastoma progression. Shiraishi R, Cancila G, Kumegawa K, Torrejon J, Basili I, Bernardi F, Silva PBGD, Wang W, Chapman O, Yang L, Jami M, Nishitani K, Arai Y, Xiao Z, Yu H, Lo Re V, Marsaud V, Talbot J, Lombard B, Loew D, Jingu M, Okonechnikov K, Sone M, Motohashi N, Aoki Y, Pfister SM, Chavez L, Hoshino M, Maruyama R, Ayrault O, Kawauchi D. Dev Cell. 2024 May 31:S1534-5807(24)00330-7. doi: 10.1016/j.devcel.2024.05.013. PubMed |
| Genome-wide CRISPR/Cas9 screen reveals JunB downmodulation of HIV co-receptor CXCR4. Schulze WJ, Gregory DA, Johnson MC, Lange MJ. Front Microbiol. 2024 May 20;15:1342444. doi: 10.3389/fmicb.2024.1342444. eCollection 2024. PubMed |
| Decreased Tiam1-mediated Rac1 activation is responsible for impaired directional persistence of chondrocyte migration in microtia. Wu Y, Liu W, Li J, Shi H, Ma S, Wang D, Pan B, Xiao R, Jiang H, Liu X. J Cell Mol Med. 2024 Jun;28(11):e18443. doi: 10.1111/jcmm.18443. PubMed |
| A targetable PRR11-DHODH axis drives ferroptosis- and temozolomide-resistance in glioblastoma. Miao Z, Xu L, Gu W, Ren Y, Li R, Zhang S, Chen C, Wang H, Ji J, Chen J. Redox Biol. 2024 Jul;73:103220. doi: 10.1016/j.redox.2024.103220. Epub 2024 May 30. PubMed |
| Targeting dependency on a paralog pair of CBP/p300 against de-repression of KREMEN2 in SMARCB1-deficient cancers. Sasaki M, Kato D, Murakami K, Yoshida H, Takase S, Otsubo T, Ogiwara H. Nat Commun. 2024 Jun 5;15(1):4770. doi: 10.1038/s41467-024-49063-w. PubMed |
Apoptosis signal-regulating kinase 1 promotes inflammation in senescence and aging.
Odawara T, Yamauchi S, Ichijo H.
Commun Biol. 2024 Jun 5;7(1):691. doi: 10.1038/s42003-024-06386-0.
PubMed
Associated Plasmids |
| Targeting the DYRK1A kinase prevents cancer progression and metastasis and promotes cancer cells response to G1/S targeting chemotherapy drugs. Laham AJ, El-Awady R, Saber-Ayad M, Wang N, Yan G, Boudreault J, Ali S, Lebrun JJ. NPJ Precis Oncol. 2024 Jun 5;8(1):128. doi: 10.1038/s41698-024-00614-w. PubMed |
| Toll-like receptor 4 signaling activation domains promote CAR T cell function against solid tumors. Mikolic V, Pantovic-Zalig J, Malensek S, Sever M, Lainscek D, Jerala R. Mol Ther Oncol. 2024 May 14;32(2):200815. doi: 10.1016/j.omton.2024.200815. eCollection 2024 Jun 20. PubMed |
| DUSP4 enhances therapeutic sensitivity in HER2-positive breast cancer by inhibiting the G6PD pathway and ROS metabolism by interacting with ALDOB. Wang X, Chi W, Ma Y, Zhang Q, Xue J, Shao ZM, Xiu B, Wu J, Chi Y. Transl Oncol. 2024 Aug;46:102016. doi: 10.1016/j.tranon.2024.102016. Epub 2024 Jun 5. PubMed |
| A CD36-dependent non-canonical lipid metabolism program promotes immune escape and resistance to hypomethylating agent therapy in AML. Guo HZ, Feng RX, Zhang YJ, Yu YH, Lu W, Liu JJ, Yang SX, Zhao C, Zhang ZL, Yu SH, Jin H, Qian SX, Li JY, Zhu J, Shi J. Cell Rep Med. 2024 Jun 18;5(6):101592. doi: 10.1016/j.xcrm.2024.101592. Epub 2024 Jun 5. PubMed |
| NSUN2/YBX1 promotes the progression of breast cancer by enhancing HGH1 mRNA stability through m(5)C methylation. Zhang X, An K, Ge X, Sun Y, Wei J, Ren W, Wang H, Wang Y, Du Y, He L, Li O, Zhou S, Shi Y, Ren T, Yang YG, Kan Q, Tian X. Breast Cancer Res. 2024 Jun 6;26(1):94. doi: 10.1186/s13058-024-01847-0. PubMed |
| Time-resolved fate mapping identifies the intestinal upper crypt zone as an origin of Lgr5+ crypt base columnar cells. Capdevila C, Miller J, Cheng L, Kornberg A, George JJ, Lee H, Botella T, Moon CS, Murray JW, Lam S, Calderon RI, Malagola E, Whelan G, Lin CS, Han A, Wang TC, Sims PA, Yan KS. Cell. 2024 Jun 6;187(12):3039-3055.e14. doi: 10.1016/j.cell.2024.05.001. PubMed |
| Caspase-4 promotes metastasis and interferon-gamma-induced pyroptosis in lung adenocarcinoma. Chiba Y, Doi T, Obayashi K, Sumida K, Nagasaka S, Wang KY, Yamasaki K, Masago K, Matsushita H, Kuroda H, Yatera K, Endo M. Commun Biol. 2024 Jun 7;7(1):699. doi: 10.1038/s42003-024-06402-3. PubMed |
| The interaction between RIPK1 and FADD controls perinatal lethality and inflammation. Rodriguez DA, Tummers B, Shaw JJP, Quarato G, Weinlich R, Cripps J, Fitzgerald P, Janke LJ, Pelletier S, Crawford JC, Green DR. Cell Rep. 2024 Jun 25;43(6):114335. doi: 10.1016/j.celrep.2024.114335. Epub 2024 Jun 8. PubMed |
| MTFP1 controls mitochondrial fusion to regulate inner membrane quality control and maintain mtDNA levels. Tabara LC, Burr SP, Frison M, Chowdhury SR, Paupe V, Nie Y, Johnson M, Villar-Azpillaga J, Viegas F, Segawa M, Anand H, Petkevicius K, Chinnery PF, Prudent J. Cell. 2024 Jul 11;187(14):3619-3637.e27. doi: 10.1016/j.cell.2024.05.017. Epub 2024 Jun 7. PubMed |
| Pure estrogen receptor antagonists potentiate capecitabine activity in ESR1-mutant breast cancer. Grinshpun A, Russo D, Ma W, Verma A, Hermida-Prado F, Sherman S, Gaglia G, Kabraji S, Kirkner G, Hughes ME, Lin NU, Sandusky Z, Nardone A, Guarducci C, Nguyen QD, Santagata S, Nagy Z, Jeselsohn R. NPJ Breast Cancer. 2024 Jun 8;10(1):42. doi: 10.1038/s41523-024-00647-1. PubMed |
| SLO2.1/NALCN Functional Complex Activity in Mouse Myometrial Smooth Muscle Cells During Pregnancy. Ferreira JJ, Kent LN, McCarthy R, Butler A, Ma X, Peramsetty N, Amazu C, Zhang A, Whitter GC, England SK, Santi CM. bioRxiv [Preprint]. 2024 Jun 2:2024.05.29.596465. doi: 10.1101/2024.05.29.596465. PubMed |
| Mitochondrial Calcium Signaling Regulates Branched-Chain Amino Acid Catabolism in Fibrolamellar Carcinoma. Marsh NM, MacEwen MJS, Chea J, Kenerson HL, Kwong AA, Locke TM, Miralles FJ, Sapre T, Gozali N, Atilla-Gokcumen GE, Ong SE, Scott JD, Yeung RS, Sancak Y. bioRxiv [Preprint]. 2024 May 28:2024.05.27.596106. doi: 10.1101/2024.05.27.596106. PubMed |
| Emergence of activation or repression in transcriptional control under a fixed molecular context. Martinez-Corral R, Friedrich D, Fromel R, Velten L, Gunawardena J, DePace AH. bioRxiv [Preprint]. 2024 Jun 2:2024.05.29.596388. doi: 10.1101/2024.05.29.596388. PubMed |
| Alpha-defensin binding expands human adenovirus tropism. Zhao C, Porter JM, Burke PC, Arnberg N, Smith JG. bioRxiv [Preprint]. 2024 May 30:2024.05.30.596681. doi: 10.1101/2024.05.30.596681. PubMed |
| Engineered Self-Regulating Macrophages for Targeted Anti-inflammatory Drug Delivery. Klimak M, Cimino A, Lenz K, Springer L, Collins K, Harasymowicz N, Xu N, Pham C, Guilak F. Res Sq [Preprint]. 2024 May 31:rs.3.rs-4385938. doi: 10.21203/rs.3.rs-4385938/v1. PubMed |
| Neratinib, a pan ERBB/HER inhibitor, restores sensitivity of PTEN-null, BRAFV600E melanoma to BRAF/MEK inhibition. DuBose E, Bevill SM, Mitchell DK, Sciaky N, Golitz BT, Dixon SAH, Rhodes SD, Bear JE, Johnson GL, Angus SP. Front Oncol. 2024 May 16;14:1191217. doi: 10.3389/fonc.2024.1191217. eCollection 2024. PubMed |
| Retrotransposons in Werner syndrome-derived macrophages trigger type I interferon-dependent inflammation in an atherosclerosis model. Paul SK, Oshima M, Patil A, Sone M, Kato H, Maezawa Y, Kaneko H, Fukuyo M, Rahmutulla B, Ouchi Y, Tsujimura K, Nakanishi M, Kaneda A, Iwama A, Yokote K, Eto K, Takayama N. Nat Commun. 2024 Jun 10;15(1):4772. doi: 10.1038/s41467-024-48663-w. PubMed |
| MYG1 drives glycolysis and colorectal cancer development through nuclear-mitochondrial collaboration. Chen J, Duan S, Wang Y, Ling Y, Hou X, Zhang S, Liu X, Long X, Lan J, Zhou M, Xu H, Zheng H, Zhou J. Nat Commun. 2024 Jun 11;15(1):4969. doi: 10.1038/s41467-024-49221-0. PubMed |
| The integrin CD11b inhibits MSU-induced NLRP3 inflammasome activation in macrophages and protects mice against MSU-induced joint inflammation. Ehirchiou D, Bernabei I, Pandian VD, Nasi S, Chobaz V, Castelblanco M, So A, Martinon F, Li X, Acha-Orbea H, Hugle T, Zhang L, Busso N. Arthritis Res Ther. 2024 Jun 11;26(1):119. doi: 10.1186/s13075-024-03350-5. PubMed |
| TNF-NF-kappaB-p53 axis restricts in vivo survival of hPSC-derived dopamine neurons. Kim TW, Koo SY, Riessland M, Chaudhry F, Kolisnyk B, Cho HS, Russo MV, Saurat N, Mehta S, Garippa R, Betel D, Studer L. Cell. 2024 Jul 11;187(14):3671-3689.e23. doi: 10.1016/j.cell.2024.05.030. Epub 2024 Jun 11. PubMed |
| GD2 and its biosynthetic enzyme GD3 synthase promote tumorigenesis in prostate cancer by regulating cancer stem cell behavior. Bhat AM, Mohapatra BC, Luan H, Mushtaq I, Chakraborty S, Kumar S, Wu W, Nolan B, Dutta S, Storck MD, Schott M, Meza JL, Lele SM, Lin MF, Cook LM, Corey E, Morrissey C, Coulter DW, Rowley MJ, Natarajan A, Datta K, Band V, Band H. Sci Rep. 2024 Jun 12;14(1):13523. doi: 10.1038/s41598-024-60052-3. PubMed |
| N6-methyladenosine-driven miR-143/145-KLF4 circuit orchestrates the phenotypic switch of pulmonary artery smooth muscle cells. Kang K, Sun C, Li H, Liu X, Deng J, Chen S, Zeng L, Chen J, Liu X, Kuang J, Xiang J, Cheng J, Liao X, Lin M, Zhang X, Zhan C, Liu S, Wang J, Niu Y, Liu C, Liang C, Zhu J, Liang S, Tang H, Gou D. Cell Mol Life Sci. 2024 Jun 12;81(1):256. doi: 10.1007/s00018-024-05304-1. PubMed |
| APOBEC3-related mutations in the spike protein-encoding region facilitate SARS-CoV-2 evolution. Shen J, Xu X, Fan J, Chen H, Zhao Y, Huang W, Liu W, Zhang Z, Cui Q, Li Q, Niu Z, Jiang D, Cao G. Heliyon. 2024 May 29;10(11):e32139. doi: 10.1016/j.heliyon.2024.e32139. eCollection 2024 Jun 15. PubMed |
| Transcriptional synergy in human aortic endothelial cells is vulnerable to combination p300/CBP and BET bromodomain inhibition. Bracken RC, Davison LM, Buehler DP, Fulton ME, Carson EE, Sheng Q, Stolze LK, Guillermier C, Steinhauser ML, Brown JD. iScience. 2024 May 16;27(6):110011. doi: 10.1016/j.isci.2024.110011. eCollection 2024 Jun 21. PubMed |
| Gain-of-function human UNC93B1 variants cause systemic lupus erythematosus and chilblain lupus. David C, Arango-Franco CA, Badonyi M, Fouchet J, Rice GI, Didry-Barca B, Maisonneuve L, Seabra L, Kechiche R, Masson C, Cobat A, Abel L, Talouarn E, Beziat V, Deswarte C, Livingstone K, Paul C, Malik G, Ross A, Adam J, Walsh J, Kumar S, Bonnet D, Bodemer C, Bader-Meunier B, Marsh JA, Casanova JL, Crow YJ, Manoury B, Fremond ML, Bohlen J, Lepelley A. J Exp Med. 2024 Aug 5;221(8):e20232066. doi: 10.1084/jem.20232066. Epub 2024 Jun 13. PubMed |
| Epigenomic signatures of sarcomatoid differentiation to guide the treatment of renal cell carcinoma. El Zarif T, Semaan K, Eid M, Seo JH, Garinet S, Davidsohn MP, Sahgal P, Fortunato B, Canniff J, Nassar AH, Abou Alaiwi S, Bakouny Z, Lakshminarayanan G, Savignano H, Lyons K, Matar S, Ali A, Saad E, Saliby RM, Cordeiro P, Zhang Z, El Ahmar N, Laimon YN, Labaki C, Shah V, Freeman D, O'Toole J, Lee GM, Hwang J, Pomerantz M, Signoretti S, Van Allen EM, Xie W, Berchuck JE, Viswanathan SR, Braun DA, Choueiri TK, Freedman ML, Baca SC. Cell Rep. 2024 Jun 25;43(6):114350. doi: 10.1016/j.celrep.2024.114350. Epub 2024 Jun 12. PubMed |
| An autoinhibitory switch of the LSD1 disordered region controls enhancer silencing. Waterbury AL, Kwok HS, Lee C, Narducci DN, Freedy AM, Su C, Raval S, Reiter AH, Hawkins W, Lee K, Li J, Hoenig SM, Vinyard ME, Cole PA, Hansen AS, Carr SA, Papanastasiou M, Liau BB. Mol Cell. 2024 Jun 20;84(12):2238-2254.e11. doi: 10.1016/j.molcel.2024.05.017. Epub 2024 Jun 12. PubMed |
| Collagen density regulates tip-stalk cell rearrangement during angiogenesis via cellular bioenergetics. Wang W, Zanotelli MR, Sabo LN, Fabiano ED, Goldfield NM, Le C, Techasiriwan EP, Lopez S, Berestesky ED, Reinhart-King CA. APL Bioeng. 2024 Jun 10;8(2):026120. doi: 10.1063/5.0195249. eCollection 2024 Jun. PubMed |
| Targeted eradication of EBV-positive cancer cells by CRISPR/dCas9-mediated EBV reactivation in combination with ganciclovir. Sugiokto FG, Li R. mBio. 2024 Jul 17;15(7):e0079524. doi: 10.1128/mbio.00795-24. Epub 2024 Jun 14. PubMed |
| Library-Assisted Evolution in Eukaryotic Cells Yield Adenine Base Editors with Enhanced Editing Specificity. Hsiao S, Chen S, Jiang Y, Wang Q, Yang Y, Lai Y, Zhong T, Liao J, Wu Y. Adv Sci (Weinh). 2024 Aug;11(30):e2309004. doi: 10.1002/advs.202309004. Epub 2024 Jun 14. PubMed |
| UM171 suppresses breast cancer progression by inducing KLF2. Ran X, Hu A, Kuang Y, Wang C, Liu W, Xiao X, Zacksenhaus E, Yu X, Ben-David Y. Breast Cancer Res Treat. 2024 Sep;207(2):405-415. doi: 10.1007/s10549-024-07372-0. Epub 2024 Jun 14. PubMed |
| Electron transport chain inhibition increases cellular dependence on purine transport and salvage. Wu Z, Bezwada D, Cai F, Harris RC, Ko B, Sondhi V, Pan C, Vu HS, Nguyen PT, Faubert B, Cai L, Chen H, Martin-Sandoval M, Do D, Gu W, Zhang Y, Zhang Y, Brooks B, Kelekar S, Zacharias LG, Oaxaca KC, Patricio JS, Mathews TP, Garcia-Bermudez J, Ni M, DeBerardinis RJ. Cell Metab. 2024 Jul 2;36(7):1504-1520.e9. doi: 10.1016/j.cmet.2024.05.014. Epub 2024 Jun 13. PubMed |
| Golgi dispersal in cancer stem cells promotes chemoresistance of colorectal cancer via the Golgi stress response. Li Y, Mu L, Li Y, Mi Y, Hu Y, Li X, Tao D, Qin J. Cell Death Dis. 2024 Jun 15;15(6):417. doi: 10.1038/s41419-024-06817-0. PubMed |
| G6PD and ACSL3 are synthetic lethal partners of NF2 in Schwann cells. Kyrkou A, Valla R, Zhang Y, Ambrosi G, Laier S, Muller-Decker K, Boutros M, Teleman AA. Nat Commun. 2024 Jun 15;15(1):5115. doi: 10.1038/s41467-024-49298-7. PubMed |
| Building a novel TRUCK by harnessing the endogenous IFN-gamma promoter for cytokine expression. Ma L, Zhang K, Xu J, Wang J, Jiang T, Du X, Zhang J, Huang J, Ren F, Liu D, Xue W, Kan D, Yao M, Liang Y, Jason-Sun H. Mol Ther. 2024 Aug 7;32(8):2728-2740. doi: 10.1016/j.ymthe.2024.06.017. Epub 2024 Jun 15. PubMed |
| Interferon regulatory factor 4 modulates epigenetic silencing and cancer-critical pathways in melanoma cells. Sobhiafshar U, Cakici B, Yilmaz E, Yildiz Ayhan N, Hedaya L, Ayhan MC, Yerinde C, Alankus YB, Gurkaslar HK, Firat-Karalar EN, Emre NCT. Mol Oncol. 2024 Oct;18(10):2423-2448. doi: 10.1002/1878-0261.13672. Epub 2024 Jun 16. PubMed |
| Tensin 4 facilitates aerobic glycolysis, migration and invasion of colorectal cancer cells through the beta‑catenin/c‑Myc signaling pathway. Wang Y, Lu Y, Xu C. Oncol Lett. 2024 Jun 3;28(2):356. doi: 10.3892/ol.2024.14489. eCollection 2024 Aug. PubMed |
| Tight Junction Component Occludin Binds to FIP5 to Regulate Endosome Trafficking and Mitotic Spindle Function. Zhang Z, Chen J, Ma R, Xu C, Lu Y, Zhou J, Xia K, Lu P. Adv Sci (Weinh). 2024 Aug;11(30):e2308822. doi: 10.1002/advs.202308822. Epub 2024 Jun 17. PubMed |
| Expression of modified FcgammaRI enables myeloid cells to elicit robust tumor-specific cytotoxicity. Farhat-Younis L, Na M, Zarfin A, Khateeb A, Santana-Magal N, Richter A, Gutwillig A, Rasoulouniriana D, Gleiberman A, Beck L, Giger T, Ashkenazi A, Barzel A, Rider P, Carmi Y. Elife. 2024 Jun 17;12:RP91999. doi: 10.7554/eLife.91999. PubMed |
| A Novel AMPK Inhibitor Sensitizes Pancreatic Cancer Cells to Ferroptosis Induction. Schneider C, Hilbert J, Genevaux F, Hofer S, Krauss L, Schicktanz F, Contreras CT, Jansari S, Papargyriou A, Richter T, Alfayomy AM, Falcomata C, Schneeweis C, Orben F, Ollinger R, Wegwitz F, Boshnakovska A, Rehling P, Muller D, Strobel P, Ellenrieder V, Conradi L, Hessmann E, Ghadimi M, Grade M, Wirth M, Steiger K, Rad R, Kuster B, Sippl W, Reichert M, Saur D, Schneider G. Adv Sci (Weinh). 2024 Aug;11(31):e2307695. doi: 10.1002/advs.202307695. Epub 2024 Jun 17. PubMed |
| Latrophilin-2 mediates fluid shear stress mechanotransduction at endothelial junctions. Tanaka K, Chen M, Prendergast A, Zhuang Z, Nasiri A, Joshi D, Hintzen J, Chung M, Kumar A, Mani A, Koleske A, Crawford J, Nicoli S, Schwartz MA. EMBO J. 2024 Aug;43(15):3175-3191. doi: 10.1038/s44318-024-00142-0. Epub 2024 Jun 17. PubMed |
| DUSP6 inhibition overcomes neuregulin/HER3-driven therapy tolerance in HER2+ breast cancer. Momeny M, Tienhaara M, Sharma M, Chakroborty D, Varjus R, Takala I, Merisaari J, Padzik A, Vogt A, Paatero I, Elenius K, Laajala TD, Kurppa KJ, Westermarck J. EMBO Mol Med. 2024 Jul;16(7):1603-1629. doi: 10.1038/s44321-024-00088-0. Epub 2024 Jun 17. PubMed |
| Sterol-like drugs potentiate statin-triggered prostate cancer cell death by inhibiting SREBP2 nuclear translocation. Dos Santos DZ, Elbaz M, Branchard E, Schormann W, Brown CE, Meek AR, Njar VCO, Hamilton RJ, Reed MA, Andrews DW, Penn LZ. Biomed Pharmacother. 2024 Aug;177:116934. doi: 10.1016/j.biopha.2024.116934. Epub 2024 Jun 17. PubMed |
| Integrative genomics identifies SHPRH as a tumor suppressor gene in lung adenocarcinoma that regulates DNA damage response. Nagelberg AL, Sihota TS, Chuang YC, Shi R, Chow JLM, English J, MacAulay C, Lam S, Lam WL, Lockwood WW. Br J Cancer. 2024 Aug;131(3):534-550. doi: 10.1038/s41416-024-02755-y. Epub 2024 Jun 18. PubMed |
| Characterization of beta-Hydroxybutyrate as a Cell Autonomous Fuel for Active Excitatory and Inhibitory Neurons: beta-Hydroxybutyrate as a Fuel for Active Neurons. Bredvik K, Liu C, Ryan TA. bioRxiv [Preprint]. 2024 Jun 9:2024.06.08.598077. doi: 10.1101/2024.06.08.598077. PubMed |
| gamma-secretase facilitates retromer-mediated retrograde transport. Takeo Y, Crite M, DiMaio D. bioRxiv [Preprint]. 2024 Jun 7:2024.06.07.597932. doi: 10.1101/2024.06.07.597932. PubMed |
| Crosstalk of MAP3K1 and EGFR signaling mediates gene-environment interactions that block developmental tissue closure. Wang J, Xiao B, Kimura E, Mongan M, Hsu WW, Medvedovic M, Puga A, Xia Y. J Biol Chem. 2024 Jul;300(7):107486. doi: 10.1016/j.jbc.2024.107486. Epub 2024 Jun 18. PubMed |
| Therapy-induced secretion of spliceosomal components mediates pro-survival crosstalk between ovarian cancer cells. Shender VO, Anufrieva KS, Shnaider PV, Arapidi GP, Pavlyukov MS, Ivanova OM, Malyants IK, Stepanov GA, Zhuravlev E, Ziganshin RH, Butenko IO, Bukato ON, Klimina KM, Veselovsky VA, Grigorieva TV, Malanin SY, Aleshikova OI, Slonov AV, Babaeva NA, Ashrafyan LA, Khomyakova E, Evtushenko EG, Lukina MM, Wang Z, Silantiev AS, Nushtaeva AA, Kharlampieva DD, Lazarev VN, Lashkin AI, Arzumanyan LK, Petrushanko IY, Makarov AA, Lebedeva OS, Bogomazova AN, Lagarkova MA, Govorun VM. Nat Commun. 2024 Jun 19;15(1):5237. doi: 10.1038/s41467-024-49512-6. PubMed |
| RNASeq highlights ATF6 pathway regulators for CHO cell engineering with different impacts of ATF6beta and WFS1 knockdown on fed-batch production of IgG(1). Rives D, Peak C, Blenner MA. Sci Rep. 2024 Jun 19;14(1):14141. doi: 10.1038/s41598-024-64767-1. PubMed |
| Novel role of NCoR1 in impairing spatial memory through the mediation of a novel interacting protein DEC2. Cheng KM, Hsu WL, Ma YL, Liu YC, Lee EHY. Cell Mol Life Sci. 2024 Jun 20;81(1):273. doi: 10.1007/s00018-024-05321-0. PubMed |
| Alpha-defensin binding expands human adenovirus tropism. Zhao C, Porter JM, Burke PC, Arnberg N, Smith JG. PLoS Pathog. 2024 Jun 20;20(6):e1012317. doi: 10.1371/journal.ppat.1012317. eCollection 2024 Jun. PubMed |
| CREB1 promotes expression of immune checkpoint HLA-E leading to immune escape in multiple myeloma. Ismael A, Robinette AJ, Huric L, Schuetz J, Dona K, Benson D, Cocucci E, Cottini F. Leukemia. 2024 Aug;38(8):1777-1786. doi: 10.1038/s41375-024-02303-w. Epub 2024 Jun 20. PubMed |
| Metallothionein 3 Potentiates Pulmonary Artery Smooth Muscle Cell Proliferation by Promoting Zinc-MTF1-ATG5 Axis-mediated Autophagosome Formation. Xiong T, Li Y, Yang M, Huo B, Guo X, Liu L, Huang Y, Zhu X, Hu Q, Wei X, Jiang DS, Yi X. Int J Biol Sci. 2024 May 11;20(8):2904-2921. doi: 10.7150/ijbs.92992. eCollection 2024. PubMed |
| Acetyl-NPKY of integrin-beta1 binds KINDLIN2 to control endothelial cell proliferation and junctional integrity. Sidibe A, Mykuliak VV, Zhang P, Hytonen VP, Wu J, Wehrle-Haller B. iScience. 2024 May 28;27(6):110129. doi: 10.1016/j.isci.2024.110129. eCollection 2024 Jun 21. PubMed |
| The receptor protein tyrosine phosphatase PTPRK promotes intestinal repair and catalysis-independent tumour suppression. Young KA, Wojdyla K, Lai T, Mulholland KE, Aldaz Casanova S, Antrobus R, Andrews SR, Biggins L, Mahler-Araujo B, Barton PR, Anderson KR, Fearnley GW, Sharpe HJ. J Cell Sci. 2024 Jul 15;137(14):jcs261914. doi: 10.1242/jcs.261914. Epub 2024 Jul 22. PubMed |
| ELM2-SANT Domain-Containing Scaffolding Protein 1 Regulates Differentiation and Maturation of Cardiomyocytes Derived From Human-Induced Pluripotent Stem Cells. Lu YA, Sun J, Wang L, Wang M, Wu Y, Getachew A, Matthews RC, Li H, Peng WG, Zhang J, Lu R, Zhou Y. J Am Heart Assoc. 2024 Jul 2;13(13):e034816. doi: 10.1161/JAHA.124.034816. Epub 2024 Jun 21. PubMed |
| IRF4 requires ARID1A to establish plasma cell identity in multiple myeloma. Bolomsky A, Ceribelli M, Scheich S, Rinaldi K, Huang DW, Chakraborty P, Pham L, Wright GW, Hsiao T, Morris V, Choi J, Phelan JD, Holewinski RJ, Andresson T, Wisniewski J, Riley D, Pittaluga S, Hill E, Thomas CJ, Muppidi J, Young RM. Cancer Cell. 2024 Jul 8;42(7):1185-1201.e14. doi: 10.1016/j.ccell.2024.05.026. Epub 2024 Jun 20. PubMed |
| Widespread chromatin context-dependencies of DNA double-strand break repair proteins. Vergara X, Manjon AG, de Haas M, Morris B, Schep R, Leemans C, Friskes A, Beijersbergen RL, Sanders MA, Medema RH, van Steensel B. Nat Commun. 2024 Jun 22;15(1):5334. doi: 10.1038/s41467-024-49232-x. PubMed |
| Protocol to identify defined reprogramming factor expression using a factor-indexing single-nuclei multiome sequencing approach. Fei L, Zhang K, Hautaniemi S, Sahu B. STAR Protoc. 2024 Sep 20;5(3):103148. doi: 10.1016/j.xpro.2024.103148. Epub 2024 Jun 22. PubMed |
| A highly effective ferritin-based divalent nanoparticle vaccine shields Syrian hamsters against lethal Nipah virus. Yin C, Yao YF, Yang P, Liu H, Gao G, Peng Y, Chen M, Lu M, Zhang X, Guo W, Zhang Z, Hu X, Yuan Z, Shan C. Front Immunol. 2024 Jun 6;15:1387811. doi: 10.3389/fimmu.2024.1387811. eCollection 2024. PubMed |
| Reduced decay-accelerating factor expression promotes complement-mediated cystogenesis in murine ADPKD. Bin S, Yoo M, Molinari P, Gentile M, Budge K, Cantarelli C, Khan Y, La Manna G, Baldwin WM, Dvorina N, Cravedi P, Gusella GL. JCI Insight. 2024 May 23;9(12):e175220. doi: 10.1172/jci.insight.175220. PubMed |
| SMAD4 depletion contributes to endocrine resistance by integrating ER and ERBB signaling in HR + HER2- breast cancer. Li K, Shu D, Li H, Lan A, Zhang W, Tan Z, Huang M, Tomasi ML, Jin A, Yu H, Shen M, Liu S. Cell Death Dis. 2024 Jun 24;15(6):444. doi: 10.1038/s41419-024-06838-9. PubMed |
| Construction and immunogenicity of SARS-CoV-2 virus-like particle expressed by recombinant baculovirus BacMam. Nguyen HT, Falzarano D, Gerdts V, Liu Q. Microbiol Spectr. 2024 Aug 6;12(8):e0095924. doi: 10.1128/spectrum.00959-24. Epub 2024 Jun 25. PubMed |
| Injury-induced Foxm1 expression in the mouse kidney drives epithelial proliferation by a cyclin F-dependent mechanism. Noonan ML, Muto Y, Yoshimura Y, Leckie-Harre A, Wu H, Kalinichenko VV, Humphreys BD, Chang-Panesso M. JCI Insight. 2024 Jun 25;9(15):e175416. doi: 10.1172/jci.insight.175416. PubMed |
Genome-scale exon perturbation screens uncover exons critical for cell fitness.
Xiao MS, Damodaran AP, Kumari B, Dickson E, Xing K, On TA, Parab N, King HE, Perez AR, Guiblet WM, Duncan G, Che A, Chari R, Andresson T, Vidigal JA, Weatheritt RJ, Aregger M, Gonatopoulos-Pournatzis T.
Mol Cell. 2024 Jul 11;84(13):2553-2572.e19. doi: 10.1016/j.molcel.2024.05.024. Epub 2024 Jun 24.
PubMed
Associated Plasmids |
Efficient, specific, and combinatorial control of endogenous exon splicing with dCasRx-RBM25.
Li JD, Taipale M, Blencowe BJ.
Mol Cell. 2024 Jul 11;84(13):2573-2589.e5. doi: 10.1016/j.molcel.2024.05.028. Epub 2024 Jun 24.
PubMed
Associated Plasmids |
| PELI2 is a negative regulator of STING signaling that is dynamically repressed during viral infection. Ritchie C, Li L. Mol Cell. 2024 Jul 11;84(13):2423-2435.e5. doi: 10.1016/j.molcel.2024.06.001. Epub 2024 Jun 24. PubMed |
| Hypoxia-Induced Long Noncoding RNA HIF1A-AS2 Regulates Stability of MHC Class I Protein in Head and Neck Cancer. Liao TT, Chen YH, Li ZY, Hsiao AC, Huang YL, Hao RX, Tai SK, Chu PY, Shih JW, Kung HJ, Yang MH. Cancer Immunol Res. 2024 Oct 1;12(10):1468-1484. doi: 10.1158/2326-6066.CIR-23-0622. PubMed |
| Transcription Factor-Mediated Generation of Dopaminergic Neurons from Human iPSCs-A Comparison of Methods. McDonald KO, Lyons NMA, Gray LKC, Xu JB, Schoderboeck L, Hughes SM, Basak I. Cells. 2024 Jun 11;13(12):1016. doi: 10.3390/cells13121016. PubMed |
| Use of FRET-Sensor 'Mermaid' to Detect Subtle Changes in Membrane Potential of Primary Mouse PASMCs. Dartsch RC, Kraut S, Mayer T, Gabel A, Dietrich A, Weissmann N, Fuchs B, Knoepp F. Cells. 2024 Jun 20;13(12):1070. doi: 10.3390/cells13121070. PubMed |
pLxIS-containing domains are biochemically flexible regulators of interferons and metabolism.
Landau LM, Chaudhary N, Tien YC, Rogozinska M, Joshi S, Yao C, Crowley J, Hullahalli K, Campbell IW, Waldor MK, Haigis M, Kagan JC.
Mol Cell. 2024 Jul 11;84(13):2436-2454.e10. doi: 10.1016/j.molcel.2024.05.030. Epub 2024 Jun 25.
PubMed
Associated Plasmids |
| Systematic transcriptome profiling of hPSC-derived osteoblasts unveils CORIN's mastery in governing osteogenesis through CEBPD modulation. Zhu D, Huang MF, Xu A, Gao X, Huang YW, Phan TTT, Lu L, Chi TY, Dai Y, Pang LK, Gingold JA, Tu J, Huo Z, Bazer DA, Shoemaker R, Wang J, Ambrose CG, Shen J, Kameoka J, Zhao Z, Wang LL, Zhang Y, Zhao R, Lee DF. J Biol Chem. 2024 Aug;300(8):107494. doi: 10.1016/j.jbc.2024.107494. Epub 2024 Jun 24. PubMed |
| METTL3-mediated chromatin contacts promote stress granule phase separation through metabolic reprogramming during senescence. Wang C, Tanizawa H, Hill C, Havas A, Zhang Q, Liao L, Hao X, Lei X, Wang L, Nie H, Qi Y, Tian B, Gardini A, Kossenkov AV, Goldman A, Berger SL, Noma KI, Adams PD, Zhang R. Nat Commun. 2024 Jun 26;15(1):5410. doi: 10.1038/s41467-024-49745-5. PubMed |
| Nuclear rupture induced by capillary constriction forces promotes differential effects on metastatic and normal breast cells. Perea Paizal J, Au SH, Bakal C. Sci Rep. 2024 Jun 26;14(1):14793. doi: 10.1038/s41598-024-64733-x. PubMed |
| Cytoprotective Role of Autophagy in CDIP1 Expression-Induced Apoptosis in MCF-7 Breast Cancer Cells. Inukai R, Mori K, Maki M, Takahara T, Shibata H. Int J Mol Sci. 2024 Jun 13;25(12):6520. doi: 10.3390/ijms25126520. PubMed |
| Modeling of Intracellular Taurine Levels Associated with Ovarian Cancer Reveals Activation of p53, ERK, mTOR and DNA-Damage-Sensing-Dependent Cell Protection. Centeno D, Farsinejad S, Kochetkova E, Volpari T, Gladych-Macioszek A, Klupczynska-Gabryszak A, Polotaye T, Greenberg M, Kung D, Hyde E, Alshehri S, Pavlovic T, Sullivan W, Plewa S, Vakifahmetoglu-Norberg H, Monsma FJ Jr, Muller PAJ, Matysiak J, Zaborowski MP, DiFeo A, Norberg E, Martin LA, Iwanicki M. Nutrients. 2024 Jun 9;16(12):1816. doi: 10.3390/nu16121816. PubMed |
| Tripartite Motif-Containing Protein 65 (TRIM65) Inhibits Hepatitis B Virus Transcription. Shen S, Yan R, Xie Z, Yu X, Liang H, You Q, Zhang H, Hou J, Zhang X, Liu Y, Sun J, Guo H. Viruses. 2024 May 31;16(6):890. doi: 10.3390/v16060890. PubMed |
| Declining Levels of Neutralizing Antibodies to SARS-CoV-2 Omicron Variants Are Enhanced by Hybrid Immunity and Original/Omicron Bivalent Vaccination. Walmsley S, Nabipoor M, Qi F, Lovblom LE, Ravindran R, Colwill K, Dayam RM, Tursun TR, Silva A, Gingras AC, On Behalf Of The STOPCoV Team. Vaccines (Basel). 2024 May 22;12(6):564. doi: 10.3390/vaccines12060564. PubMed |
| A Unique mRNA Vaccine Elicits Protective Efficacy against the SARS-CoV-2 Omicron Variant and SARS-CoV. Guan X, Verma AK, Wang G, Roy A, Perlman S, Du L. Vaccines (Basel). 2024 Jun 1;12(6):605. doi: 10.3390/vaccines12060605. PubMed |
| S2 Peptide-Conjugated SARS-CoV-2 Virus-like Particles Provide Broad Protection against SARS-CoV-2 Variants of Concern. Heo CK, Lim WH, Moon KB, Yang J, Kim SJ, Kim HS, Kim DJ, Cho EW. Vaccines (Basel). 2024 Jun 18;12(6):676. doi: 10.3390/vaccines12060676. PubMed |
| ONECUT2 acts as a lineage plasticity driver in adenocarcinoma as well as neuroendocrine variants of prostate cancer. Qian C, Yang Q, Rotinen M, Huang R, Kim H, Gallent B, Yan Y, Cadaneanu RM, Zhang B, Kaochar S, Freedland SJ, Posadas EM, Ellis L, Di Vizio D, Morrissey C, Nelson PS, Brady L, Murali R, Campbell MJ, Yang W, Knudsen BS, Mostaghel EA, Ye H, Garraway IP, You S, Freeman MR. Nucleic Acids Res. 2024 Jul 22;52(13):7740-7760. doi: 10.1093/nar/gkae547. PubMed |
| Casein kinase 1alpha mediates phosphorylation of the Merkel cell polyomavirus large T antigen for beta-TrCP destruction complex interaction and subsequent degradation. Pham AM, Kwun HJ. mBio. 2024 Aug 14;15(8):e0111724. doi: 10.1128/mbio.01117-24. Epub 2024 Jun 28. PubMed |
| MicroRNA-384 radiosensitizes human non-small cell lung cancer by impairing DNA damage response and repair signaling, which is inhibited by NF-kappaB. Sun Y, Wang J, Qiu M, Zhao J, Zou F, Meng M, Jiang X, Yuan Z, Mi Z, Wu Z. Cancer Biol Med. 2024 Jun 27;21(11):1050-66. doi: 10.20892/j.issn.2095-3941.2024.0146. PubMed |
| The centrosomal protein FGFR1OP controls myosin function in murine intestinal epithelial cells. Trsan T, Peng V, Krishna C, Ohara TE, Beatty WL, Sudan R, Kanai M, Krishnamoorthy P, Rodrigues PF, Fachi JL, Grajales-Reyes G, Jaeger N, Fitzpatrick JAJ, Cella M, Gilfillan S, Nakata T, Jaiswal A, Stappenbeck TS, Daly MJ, Xavier RJ, Colonna M. Dev Cell. 2024 Sep 23;59(18):2460-2476.e10. doi: 10.1016/j.devcel.2024.06.001. Epub 2024 Jun 27. PubMed |
| PRPF40A induces inclusion of exons in GC-rich regions important for human myeloid cell differentiation. Tan CW, Sim DY, Zhen Y, Tian H, Koh J, Roca X. Nucleic Acids Res. 2024 Aug 27;52(15):8800-8814. doi: 10.1093/nar/gkae557. PubMed |
| BACH1 inhibits senescence, obesity, and short lifespan by ferroptotic FGF21 secretion. Nishizawa H, Matsumoto M, Yamanaka M, Irikura R, Nakajima K, Tada K, Nakayama Y, Konishi M, Itoh N, Funayama R, Nakayama K, Igarashi K. Cell Rep. 2024 Jul 23;43(7):114403. doi: 10.1016/j.celrep.2024.114403. Epub 2024 Jun 27. PubMed |
| Translocational attenuation mediated by the PERK-SRP14 axis is a protective mechanism of unfolded protein response. Liu Y, Gu Y, Chen Y, Wang X, Zhou G, Li J, Wang M, Fang S, Yang Y. Cell Rep. 2024 Jul 23;43(7):114402. doi: 10.1016/j.celrep.2024.114402. Epub 2024 Jun 27. PubMed |
| Cathepsin L induces cellular senescence by upregulating CUX1 and p16(INK4a). Wu Y, Jiang D, Liu Q, Yan S, Liu X, Wu T, Sun W, Li G. Aging (Albany NY). 2024 Jun 18;16(13):10749-10764. doi: 10.18632/aging.205955. Epub 2024 Jun 18. PubMed |
| Chemo-small extracellular vesicles released in cisplatin-resistance ovarian cancer cells are regulated by the lysosomal function. Cerda-Troncoso C, Grunenwald F, Arias-Munoz E, Cavieres VA, Caceres-Verschae A, Hernandez S, Gaete-Ramirez B, Alvarez-Astudillo F, Acuna RA, Ostrowski M, Burgos PV, Varas-Godoy M. J Extracell Biol. 2024 May 30;3(6):e157. doi: 10.1002/jex2.157. eCollection 2024 Jun. PubMed |
| TRMT10A dysfunction perturbs codon translation of initiator methionine and glutamine and impairs brain functions in mice. Tresky R, Miyamoto Y, Nagayoshi Y, Yabuki Y, Araki K, Takahashi Y, Komohara Y, Ge H, Nishiguchi K, Fukuda T, Kaneko H, Maeda N, Matsuura J, Iwasaki S, Sakakida K, Shioda N, Wei FY, Tomizawa K, Chujo T. Nucleic Acids Res. 2024 Aug 27;52(15):9230-9246. doi: 10.1093/nar/gkae520. PubMed |
| YTHDC1 m(6)A-dependent and m(6)A-independent functions converge to preserve the DNA damage response. Elvira-Blazquez D, Fernandez-Justel JM, Arcas A, Statello L, Goni E, Gonzalez J, Ricci B, Zaccara S, Raimondi I, Huarte M. EMBO J. 2024 Aug;43(16):3494-3522. doi: 10.1038/s44318-024-00153-x. Epub 2024 Jul 1. PubMed |
| The histamine receptor H1 acts as an alternative receptor for SARS-CoV-2. Yu F, Liu X, Ou H, Li X, Liu R, Lv X, Xiao S, Hu M, Liang T, Chen T, Wei X, Zhang Z, Liu S, Liu H, Zhu Y, Liu G, Tu T, Li P, Zhang H, Pan T, Ma X. mBio. 2024 Aug 14;15(8):e0108824. doi: 10.1128/mbio.01088-24. Epub 2024 Jul 2. PubMed |
| IFNgamma mediates the resistance of tumor cells to distinct NK cell subsets. Hofman T, Ng SW, Garces-Lazaro I, Heigwer F, Boutros M, Cerwenka A. J Immunother Cancer. 2024 Jul 1;12(7):e009410. doi: 10.1136/jitc-2024-009410. PubMed |
| An HIV-1 CRISPR-Cas9 membrane trafficking screen reveals a role for PICALM intersecting endolysosomes and immunity. Guizar P, Abdalla AL, Monette A, Davis K, Caballero RE, Niu M, Liu X, Ajibola O, Murooka TT, Liang C, Mouland AJ. iScience. 2024 May 27;27(6):110131. doi: 10.1016/j.isci.2024.110131. eCollection 2024 Jun 21. PubMed |
| YAP1 Suppression by ZDHHC7 Is Associated with Ferroptosis Resistance and Poor Prognosis in Ovarian Clear Cell Carcinoma. Furutake Y, Yamaguchi K, Yamanoi K, Kitamura S, Takamatsu S, Taki M, Ukita M, Hosoe Y, Murakami R, Abiko K, Horie A, Hamanishi J, Baba T, Matsumura N, Mandai M. Mol Cancer Ther. 2024 Nov 4;23(11):1652-1665. doi: 10.1158/1535-7163.MCT-24-0145. PubMed |
| Hsp47 promotes biogenesis of multi-subunit neuroreceptors in the endoplasmic reticulum. Wang YJ, Di XJ, Zhang PP, Chen X, Williams MP, Han DY, Nashmi R, Henderson BJ, Moss FJ, Mu TW. Elife. 2024 Jul 4;13:e84798. doi: 10.7554/eLife.84798. PubMed |
| ALDH1A3-acetaldehyde metabolism potentiates transcriptional heterogeneity in melanoma. Lu Y, Travnickova J, Badonyi M, Rambow F, Coates A, Khan Z, Marques J, Murphy LC, Garcia-Martinez P, Marais R, Louphrasitthiphol P, Chan AHY, Schofield CJ, von Kriegsheim A, Marsh JA, Pavet V, Sansom OJ, Illingworth RS, Patton EE. Cell Rep. 2024 Jul 23;43(7):114406. doi: 10.1016/j.celrep.2024.114406. Epub 2024 Jul 3. PubMed |
| USP9X inhibits metastasis in pulmonary sarcomatoid carcinoma by regulating epithelial-mesenchymal transition, angiogenesis and immune infiltration. Feng Q, Liu Q, Liu Z, Xu J, Yang Y, Zhu Y, Lu G, Xu G, Wu D, Wang F, Liu B, Wang W, Ding X. Transl Oncol. 2024 Sep;47:101950. doi: 10.1016/j.tranon.2024.101950. Epub 2024 Jul 3. PubMed |
| The two-faced role of RNA methyltransferase METTL3 on cellular response to cisplatin in head and neck squamous cell carcinoma in vitro model. Ostrowska K, Rawluszko-Wieczorek AA, Ostapowicz J, Suchorska WM, Golusinski W. Front Oncol. 2024 Jun 19;14:1402126. doi: 10.3389/fonc.2024.1402126. eCollection 2024. PubMed |
| Elevating PLK1 overcomes BETi resistance in prostate cancer via triggering BRD4 phosphorylation-dependent degradation in mitosis. Zhang Y, Fong KW, Mao F, Wang R, Allison DB, Napier D, He D, Liu J, Zhang Y, Chen J, Kong Y, Li C, Li G, Liu J, Li Z, Zhu H, Wang C, Liu X. Cell Rep. 2024 Jul 23;43(7):114431. doi: 10.1016/j.celrep.2024.114431. Epub 2024 Jul 4. PubMed |
Clonal Lineage Tracing with Somatic Delivery of Recordable Barcodes Reveals Migration Histories of Metastatic Prostate Cancer.
Serio RN, Scheben A, Lu B, Gargiulo DV, Patruno L, Buckholtz CL, Chaffee RJ, Jibilian MC, Persaud SG, Staklinski SJ, Hassett R, Brault LM, Ramazzotti D, Barbieri CE, Siepel AC, Nowak DG.
Cancer Discov. 2024 Jul 5. doi: 10.1158/2159-8290.CD-23-1332.
PubMed
Associated Plasmids |
| The septin cytoskeleton is required for plasma membrane repair. Prislusky MI, Lam JGT, Contreras VR, Ng M, Chamberlain M, Pathak-Sharma S, Fields M, Zhang X, Amer AO, Seveau S. EMBO Rep. 2024 Sep;25(9):3870-3895. doi: 10.1038/s44319-024-00195-6. Epub 2024 Jul 5. PubMed |
| Plakophilin 4 controls the spatio-temporal activity of RhoA at adherens junctions to promote cortical actin ring formation and tissue tension. Muller L, Keil R, Glass M, Hatzfeld M. Cell Mol Life Sci. 2024 Jul 6;81(1):291. doi: 10.1007/s00018-024-05329-6. PubMed |
| KAT6A Condensates Impair PARP1 Trapping of PARP Inhibitors in Ovarian Cancer. Zhan Z, Zhang J, Liang H, Wang C, Hong L, Liu W. Adv Sci (Weinh). 2024 Sep;11(34):e2400140. doi: 10.1002/advs.202400140. Epub 2024 Jul 8. PubMed |
| Replicative senescence is ATM driven, reversible, and accelerated by hyperactivation of ATM at normoxia. Stuart A, de Lange T. bioRxiv [Preprint]. 2024 Jun 26:2024.06.24.600514. doi: 10.1101/2024.06.24.600514. PubMed |
| Crosstalk between epitranscriptomic and epigenomic modifications and its implication in human diseases. Li C, Chen K, Fang Q, Shi S, Nan J, He J, Yin Y, Li X, Li J, Hou L, Hu X, Kellis M, Han X, Xiong X. Cell Genom. 2024 Aug 14;4(8):100605. doi: 10.1016/j.xgen.2024.100605. Epub 2024 Jul 8. PubMed |
| A non-canonical role for a small nucleolar RNA in ribosome biogenesis and senescence. Cheng Y, Wang S, Zhang H, Lee JS, Ni C, Guo J, Chen E, Wang S, Acharya A, Chang TC, Buszczak M, Zhu H, Mendell JT. Cell. 2024 Aug 22;187(17):4770-4789.e23. doi: 10.1016/j.cell.2024.06.019. Epub 2024 Jul 8. PubMed |
| The IRE1alpha/XBP1 signaling axis drives myoblast fusion in adult skeletal muscle. Joshi AS, Tomaz da Silva M, Roy A, Koike TE, Wu M, Castillo MB, Gunaratne PH, Liu Y, Iwawaki T, Kumar A. EMBO Rep. 2024 Aug;25(8):3627-3650. doi: 10.1038/s44319-024-00197-4. Epub 2024 Jul 9. PubMed |
| Simple aneuploidy evades p53 surveillance and promotes niche factor-independent growth in human intestinal organoids. Johnson BA, Liu AZ, Bi T, Dong Y, Li T, Zhou D, Narkar A, Wu Y, Sun SX, Larman TC, Zhu J, Li R. Mol Biol Cell. 2024 Aug 1;35(8):br15. doi: 10.1091/mbc.E24-04-0166. Epub 2024 Jul 10. PubMed |
| SART3 reads methylarginine-marked glycine- and arginine-rich motifs. Wang Y, Zhou J, He W, Fu R, Shi L, Dang NK, Liu B, Xu H, Cheng X, Bedford MT. Cell Rep. 2024 Jul 23;43(7):114459. doi: 10.1016/j.celrep.2024.114459. Epub 2024 Jul 9. PubMed |
| Synthetic lethal CRISPR screen identifies a cancer cell-intrinsic role of PD-L1 in regulation of vulnerability to ferroptosis. Feng YY, Li YC, Liu HM, Xu R, Liu YT, Zhang W, Yang HY, Chen G. Cell Rep. 2024 Jul 23;43(7):114477. doi: 10.1016/j.celrep.2024.114477. Epub 2024 Jul 11. PubMed |
| The hydrophobicity of the CARD8 N-terminus tunes inflammasome activation. Tsamouri LP, Hsiao JC, Wang Q, Geeson MB, Huang HC, Nambiar DR, Zou M, Ball DP, Chui AJ, Bachovchin DA. Cell Chem Biol. 2024 Sep 19;31(9):1699-1713.e8. doi: 10.1016/j.chembiol.2024.06.004. Epub 2024 Jul 10. PubMed |
| Metabolic Profiling of Cochlear Organoids Identifies alpha-Ketoglutarate and NAD(+) as Limiting Factors for Hair Cell Reprogramming. Liu Q, Zhang L, Chen Z, He Y, Huang Y, Qiu C, Zhu C, Zhou D, Gan Z, Gao X, Wan G. Adv Sci (Weinh). 2024 Sep;11(34):e2308032. doi: 10.1002/advs.202308032. Epub 2024 Jul 11. PubMed |
| Loss of Lamin A leads to the nuclear translocation of AGO2 and compromised RNA interference. Lobo V, Nowak I, Fernandez C, Correa Muler AI, Westholm JO, Huang HC, Fabrik I, Huynh HT, Shcherbinina E, Poyraz M, Hartlova A, Benhalevy D, Angeletti D, Sarshad AA. Nucleic Acids Res. 2024 Sep 9;52(16):9917-9935. doi: 10.1093/nar/gkae589. PubMed |
| Local vascular Klotho mediates diabetes-induced atherosclerosis via ERK1/2 and PI3-kinase-dependent signaling pathways. Ajay AK, Zhu LJ, Zhao L, Liu Q, Ding Y, Chang YC, Shah SI, Hsiao LL. Atherosclerosis. 2024 Sep;396:118531. doi: 10.1016/j.atherosclerosis.2024.118531. Epub 2024 Jul 3. PubMed |
| Mutation-induced LZTR1 polymerization provokes cardiac pathology in recessive Noonan syndrome. Busley AV, Gutierrez-Gutierrez O, Hammer E, Koitka F, Mirzaiebadizi A, Steinegger M, Pape C, Bohmer L, Schroeder H, Kleinsorge M, Engler M, Cirstea IC, Gremer L, Willbold D, Altmuller J, Marbach F, Hasenfuss G, Zimmermann WH, Ahmadian MR, Wollnik B, Cyganek L. Cell Rep. 2024 Jul 23;43(7):114448. doi: 10.1016/j.celrep.2024.114448. Epub 2024 Jul 13. PubMed |
| Renal protection after hemorrhagic shock in rats: Possible involvement of SUMOylation. Oliveira FRMB, Sousa Soares E, Pillmann Ramos H, Lattig-Tunnemann G, Harms C, Cimarosti H, Sordi R. Biochem Pharmacol. 2024 Sep;227:116425. doi: 10.1016/j.bcp.2024.116425. Epub 2024 Jul 14. PubMed |
| Co-option of mitochondrial nucleic acid sensing pathways by HSV-1 UL12.5 for reactivation from latent Infection. Cuddy SR, Flores ME, Krakowiak PA, Whitford AL, Dochnal SA, Babnis A, Miyake T, Tigano M, Engel DA, Cliffe AR. bioRxiv [Preprint]. 2024 Jul 9:2024.07.06.601241. doi: 10.1101/2024.07.06.601241. PubMed |
| Reduced adipocyte glutaminase activity promotes energy expenditure and metabolic health. Lecoutre S, Maqdasy S, Rizo-Roca D, Renzi G, Vlassakev I, Alaeddine LM, Higos R, Jalkanen J, Zhong J, Zareifi DS, Frendo-Cumbo S, Massier L, Hodek O, Juvany M, Moritz T, de Castro Barbosa T, Omar-Hmeadi M, Lopez-Yus M, Merabtene F, Abatan JB, Marcelin G, El Hachem EJ, Rouault C, Bergo MO, Petrus P, Zierath JR, Clement K, Krook A, Mejhert N, Ryden M. Nat Metab. 2024 Jul;6(7):1329-1346. doi: 10.1038/s42255-024-01083-y. Epub 2024 Jul 15. PubMed |
| Repression of mRNA translation initiation by GIGYF1 via disrupting the eIF3-eIF4G1 interaction. Choi JH, Luo J, Hesketh GG, Guo S, Pistofidis A, Ladak RJ, An Y, Naeli P, Alain T, Schmeing TM, Gingras AC, Duchaine T, Zhang X, Sonenberg N, Jafarnejad SM. Sci Adv. 2024 Jul 19;10(29):eadl5638. doi: 10.1126/sciadv.adl5638. Epub 2024 Jul 17. PubMed |
| In vivo single-cell CRISPR uncovers distinct TNF programmes in tumour evolution. Renz PF, Ghoshdastider U, Baghai Sain S, Valdivia-Francia F, Khandekar A, Ormiston M, Bernasconi M, Dure C, Kretz JA, Lee M, Hyams K, Forny M, Pohly M, Ficht X, Ellis SJ, Moor AE, Sendoel A. Nature. 2024 Aug;632(8024):419-428. doi: 10.1038/s41586-024-07663-y. Epub 2024 Jul 17. PubMed |
| Activation of the PERK/eIF2alpha axis is a pivotal prerequisite of taxanes to cancer cell apoptosis and renders synergism to overcome paclitaxel resistance in breast cancer cells. Cai W, Rong D, Ding J, Zhang X, Wang Y, Fang Y, Xiao J, Yang S, Wang H. Cancer Cell Int. 2024 Jul 17;24(1):249. doi: 10.1186/s12935-024-03443-w. PubMed |
| Regulation of the DLC3 tumor suppressor by a novel phosphoswitch. Frey Y, Lungu C, Meyer F, Hauth F, Hahn D, Kersten C, Heller V, Franz-Wachtel M, Macek B, Barsukov I, Olayioye MA. iScience. 2024 Jun 6;27(7):110203. doi: 10.1016/j.isci.2024.110203. eCollection 2024 Jul 19. PubMed |
| The TDP-43/TP63 Positive Feedback Circuit Promotes Esophageal Squamous Cell Carcinoma Progression. Li W, Yang Y, Huang L, Yu X, Wang T, Zhang N, Yang M. Adv Sci (Weinh). 2024 Sep;11(35):e2402913. doi: 10.1002/advs.202402913. Epub 2024 Jul 18. PubMed |
| Unveiling the oncogenic role of LZTS1 in colorectal cancer. Xu Y, Pepe D, Yao S, Boudhan L, Verbandt S, Pu T, Creemers JWM, Liu M, Tejpar S, He Z, Zhu J, Wang Y. J Cell Mol Med. 2024 Jul;28(14):e18441. doi: 10.1111/jcmm.18441. PubMed |
| The splicing factor CCAR1 regulates the Fanconi anemia/BRCA pathway. Harada N, Asada S, Jiang L, Nguyen H, Moreau L, Marina RJ, Adelman K, Iyer DR, D'Andrea AD. Mol Cell. 2024 Jul 25;84(14):2618-2633.e10. doi: 10.1016/j.molcel.2024.06.031. Epub 2024 Jul 17. PubMed |
| Combined inhibition of KRAS(G12C) and mTORC1 kinase is synergistic in non-small cell lung cancer. Kitai H, Choi PH, Yang YC, Boyer JA, Whaley A, Pancholi P, Thant C, Reiter J, Chen K, Markov V, Taniguchi H, Yamaguchi R, Ebi H, Evans J, Jiang J, Lee B, Wildes D, de Stanchina E, Smith JAM, Singh M, Rosen N. Nat Commun. 2024 Jul 19;15(1):6076. doi: 10.1038/s41467-024-50063-z. PubMed |
| Nup358 restricts ER-mitochondria connectivity by modulating mTORC2/Akt/GSK3beta signalling. Kalarikkal M, Saikia R, Oliveira L, Bhorkar Y, Lonare A, Varshney P, Dhamale P, Majumdar A, Joseph J. EMBO Rep. 2024 Oct;25(10):4226-4251. doi: 10.1038/s44319-024-00204-8. Epub 2024 Jul 18. PubMed |
| Efficient Genome Editing with Chimeric Oligonucleotide-Directed Editing. Nguyen LT, Rakestraw NR, Pizzano BLM, Young CB, Huang Y, Beerensson KT, Fang A, Antal SG, Anamisis KV, Peggs CMD, Yan J, Jing Y, Burdine RD, Adamson B, Toettcher JE, Myhrvold C, Jain PK. bioRxiv [Preprint]. 2024 Jul 10:2024.07.09.602710. doi: 10.1101/2024.07.09.602710. PubMed |
| Acute BRCAness Induction and AR Signaling Blockage through CDK12/7/9 Degradation Enhances PARP Inhibitor Sensitivity in Prostate Cancer. Gui F, Jiang B, Jiang J, He Z, Tsujino T, Takai T, Arai S, Pana C, Kollermann J, Bradshaw GA, Eisert R, Kalocsay M, Fassl A, Balk SP, Kibel AS, Jia L. bioRxiv [Preprint]. 2024 Nov 7:2024.07.09.602803. doi: 10.1101/2024.07.09.602803. PubMed |
| Tau phosphorylation suppresses oxidative stress-induced mitophagy via FKBP8 receptor modulation. Isei MO, Crockett M, Chen E, Rodwell-Bullock J, Caroll T, Girardi PA, Nehrke K, Johnson GV. bioRxiv [Preprint]. 2024 Jul 9:2024.07.05.602170. doi: 10.1101/2024.07.05.602170. PubMed |
| Protocol for transducing human primary epithelial prostate cells and patient-derived organoids with high efficiency. Jobin C, Harvey M, Lacouture A, Weidmann C, Neveu B, Pouliot F, Audet-Walsh E. STAR Protoc. 2024 Sep 20;5(3):103200. doi: 10.1016/j.xpro.2024.103200. Epub 2024 Jul 18. PubMed |
| Mammalian SWI/SNF complex activity regulates POU2F3 and constitutes a targetable dependency in small cell lung cancer. Duplaquet L, So K, Ying AW, Pal Choudhuri S, Li X, Xu GD, Li Y, Qiu X, Li R, Singh S, Wu XS, Hamilton S, Chien VD, Liu Q, Qi J, Somerville TDD, Heiling HM, Mazzola E, Lee Y, Zoller T, Vakoc CR, Doench JG, Forrester WC, Abrams T, Long HW, Niederst MJ, Drapkin BJ, Kadoch C, Oser MG. Cancer Cell. 2024 Aug 12;42(8):1352-1369.e13. doi: 10.1016/j.ccell.2024.06.012. Epub 2024 Jul 18. PubMed |
| Host cell CRISPR genomics and modelling reveal shared metabolic vulnerabilities in the intracellular development of Plasmodium falciparum and related hemoparasites. Maurizio M, Masid M, Woods K, Caldelari R, Doench JG, Naguleswaran A, Joly D, Gonzalez-Fernandez M, Zemp J, Borteele M, Hatzimanikatis V, Heussler V, Rottenberg S, Olias P. Nat Commun. 2024 Jul 21;15(1):6145. doi: 10.1038/s41467-024-50405-x. PubMed |
| Molecular insights into degron recognition by CRL5(ASB7) ubiquitin ligase. Zhou M, Wang X, Li J, Ma J, Bao Z, Yan X, Zhang B, Liu T, Yu Y, Mi W, Dong C. Nat Commun. 2024 Jul 22;15(1):6177. doi: 10.1038/s41467-024-50556-x. PubMed |
| Targeting RBM39 through indisulam induced mis-splicing of mRNA to exert anti-cancer effects in T-cell acute lymphoblastic leukemia. Ji T, Yang Y, Yu J, Yin H, Chu X, Yang P, Xu L, Wang X, Hu S, Li Y, Wu X, Liu W, Zhou B, Wang W, Zhang S, Cheng W, Chen Y, Shi L, Li Z, Zhuo R, Zhang Y, Tao Y, Wu D, Li X, Zhang Z, Fan JJ, Pan J, Lu J. J Exp Clin Cancer Res. 2024 Jul 24;43(1):205. doi: 10.1186/s13046-024-03130-8. PubMed |
| LACTB suppresses liver cancer progression through regulation of ferroptosis. Zeng K, Huang N, Liu N, Deng X, Mu Y, Zhang X, Zhang J, Zhang C, Li Y, Li Z. Redox Biol. 2024 Sep;75:103270. doi: 10.1016/j.redox.2024.103270. Epub 2024 Jul 18. PubMed |
| MTGR1 is required to maintain small intestinal stem cell populations. Short SP, Brown RE, Chen Z, Pilat JM, McElligott BA, Meenderink LM, Bickart AC, Blunt KM, Jacobse J, Wang J, Simmons AJ, Xu Y, Yang Y, Parang B, Choksi YA, Goettel JA, Lau KS, Hiebert SW, Williams CS. Cell Death Differ. 2024 Sep;31(9):1170-1183. doi: 10.1038/s41418-024-01346-x. Epub 2024 Jul 25. PubMed |
| Shifts in receptors during submergence of an encephalitic arbovirus. Li W, Plante JA, Lin C, Basu H, Plung JS, Fan X, Boeckers JM, Oros J, Buck TK, Anekal PV, Hanson WA, Varnum H, Wells A, Mann CJ, Tjang LV, Yang P, Reyna RA, Mitchell BM, Shinde DP, Walker JL, Choi SY, Brusic V, Llopis PM, Weaver SC, Umemori H, Chiu IM, Plante KS, Abraham J. Nature. 2024 Aug;632(8025):614-621. doi: 10.1038/s41586-024-07740-2. Epub 2024 Jul 24. PubMed |
| beta-catenin mediates endodermal commitment of human ES cells via distinct transactivation functions. Ma X, Dai L, Tan C, Li J, He X, Wang Y, Xue J, Huang M, Ren J, Xia Y, Wu Q, Zhao H, Chan WY, Feng B. Cell Biosci. 2024 Jul 24;14(1):96. doi: 10.1186/s13578-024-01279-5. PubMed |
| Cytidine triphosphate synthase 1-mediated metabolic reprogramming promotes proliferation and drug resistance in multiple myeloma. Huang H, Chen Y, Li Y, Zheng X, Shu L, Tian L, Lin H, Liang Y. Heliyon. 2024 Jun 20;10(13):e33001. doi: 10.1016/j.heliyon.2024.e33001. eCollection 2024 Jul 15. PubMed |
| VHL loss enhances antitumor immunity by activating the anti-viral DNA-sensing pathway. Jiao M, Hu M, Pan D, Liu X, Bao X, Kim J, Li F, Li CY. iScience. 2024 Jun 15;27(7):110285. doi: 10.1016/j.isci.2024.110285. eCollection 2024 Jul 19. PubMed |
| Metastatic breast cancer cells are metabolically reprogrammed to maintain redox homeostasis during metastasis. Biondini M, Lehuede C, Tabaries S, Annis MG, Pacis A, Ma EH, Tam C, Hsu BE, Audet-Delage Y, Abu-Thuraia A, Girondel C, Sabourin V, Totten SP, de Sa Tavares Russo M, Bridon G, Avizonis D, Guiot MC, St-Pierre J, Ursini-Siegel J, Jones R, Siegel PM. Redox Biol. 2024 Sep;75:103276. doi: 10.1016/j.redox.2024.103276. Epub 2024 Jul 20. PubMed |
| Olanzapine suppresses mPFC activity-norepinephrine releasing to alleviate CLOCK-enhanced cancer stemness under chronic stress. Lu J, Zhang X, Su K, Luo H, Liu C, Yang Y, He B, Wang C, Zhao Z, Liu X, Wang X, Meng P, Lv D, Wang C, Kelley KW, Wang L, Cui B, Liu Q, Peng F. Cell Commun Signal. 2024 Jul 25;22(1):375. doi: 10.1186/s12964-024-01747-y. PubMed |
| Tumoral Interferon Beta Induces an Immune-Stimulatory Phenotype in Tumor-Associated Macrophages in Melanoma Brain Metastases. Gellert J, Agardy DA, Kumar S, Kourtesakis A, Boschert T, Jahne K, Breckwoldt MO, Bunse L, Wick W, Davies MA, Platten M, Bunse T. Cancer Res Commun. 2024 Aug 1;4(8):2189-2202. doi: 10.1158/2767-9764.CRC-24-0024. PubMed |
| Initial Characterization of WDR5B Reveals a Role in the Proliferation of Retinal Pigment Epithelial Cells. Bailey JK, Ma D, Clegg DO. Cells. 2024 Jul 13;13(14):1189. doi: 10.3390/cells13141189. PubMed |
| Developing Device of Death Operation (DODO) to Detect Apoptosis in 2D and 3D Cultures. Zhang Z, Sun Z, Liu JL. Cells. 2024 Jul 20;13(14):1224. doi: 10.3390/cells13141224. PubMed |
Polysome collapse and RNA condensation fluidize the cytoplasm.
Xie Y, Shu T, Liu T, Spindler MC, Mahamid J, Hocky GM, Gresham D, Holt LJ.
Mol Cell. 2024 Jul 25;84(14):2698-2716.e9. doi: 10.1016/j.molcel.2024.06.024.
PubMed
Associated Plasmids |
| SARS-CoV-2 Accessory Protein ORF8 Targets the Dimeric IgA Receptor pIgR. Laprise F, Arduini A, Duguay M, Pan Q, Liang C. Viruses. 2024 Jun 22;16(7):1008. doi: 10.3390/v16071008. PubMed |
| Glucocorticoid receptor controls atopic dermatitis inflammation via functional interactions with P63 and autocrine signaling in epidermal keratinocytes. Sevilla LM, Pons-Alonso O, Gallego A, Azkargorta M, Elortza F, Perez P. Cell Death Dis. 2024 Jul 28;15(7):535. doi: 10.1038/s41419-024-06926-w. PubMed |
| Modulations of the mTORC2-GATA3 axis by an isorhamnetin activated endosomal-lysosomal system of the J774.1 macrophage-like cell line. Sakai M, Ohnishi K, Masuda M, Harumoto E, Fukuda T, Ohnishi A, Ishii S, Ohminami H, Yamanaka-Okumura H, Ohashi K, Itakura E, Horikawa K, Yonemura S, Hara T, Taketani Y. J Clin Biochem Nutr. 2024 Jul;75(1):24-32. doi: 10.3164/jcbn.24-22. Epub 2024 Mar 20. PubMed |
| DCAF16-Based Covalent Handle for the Rational Design of Monovalent Degraders. Lim M, Cong TD, Orr LM, Toriki ES, Kile AC, Papatzimas JW, Lee E, Lin Y, Nomura DK. ACS Cent Sci. 2024 May 17;10(7):1318-1331. doi: 10.1021/acscentsci.4c00286. eCollection 2024 Jul 24. PubMed |
| A genome-wide CRISPR/Cas9 screen identifies calreticulin as a selective repressor of ATF6alpha. Tung J, Huang L, George G, Harding HP, Ron D, Ordonez A. Elife. 2024 Jul 29;13:RP96979. doi: 10.7554/eLife.96979. PubMed |
| Deubiquitinase USP9x regulates the proline biosynthesis pathway in non-small cell lung cancer. Becirovic T, Zhang B, Lindskog C, Norberg E, Vakifahmetoglu-Norberg H, Kaminskyy VO, Kochetkova E. Cell Death Discov. 2024 Jul 29;10(1):342. doi: 10.1038/s41420-024-02111-2. PubMed |
| Altered ribosomal profile in acquired resistance and reversal associates with pathological response to chemotherapy in inflammatory breast cancer. Devi GR, Pai P, Lee S, Foster MW, Sannareddy DS, Bertucci F, Ueno N, Van Laere S. NPJ Breast Cancer. 2024 Jul 29;10(1):65. doi: 10.1038/s41523-024-00664-0. PubMed |
| The deubiquitinase OTUD1 stabilizes NRF2 to alleviate hepatic ischemia/reperfusion injury. Zhang Q, Chen Z, Li J, Huang K, Ding Z, Chen B, Ren T, Xu P, Wang G, Zhang H, Zhang XD, Zhang J, Wang H. Redox Biol. 2024 Sep;75:103287. doi: 10.1016/j.redox.2024.103287. Epub 2024 Jul 26. PubMed |
| Harnessing DNA replication stress to target RBM10 deficiency in lung adenocarcinoma. Machour FE, R Abu-Zhayia E, Kamar J, Barisaac AS, Simon I, Ayoub N. Nat Commun. 2024 Jul 30;15(1):6417. doi: 10.1038/s41467-024-50882-0. PubMed |
| mTORC2-driven chromatin cGAS mediates chemoresistance through epigenetic reprogramming in colorectal cancer. Lv G, Wang Q, Lin L, Ye Q, Li X, Zhou Q, Kong X, Deng H, You F, Chen H, Wu S, Yuan L. Nat Cell Biol. 2024 Sep;26(9):1585-1596. doi: 10.1038/s41556-024-01473-0. Epub 2024 Jul 30. PubMed |
| The Derlin-1-Stat5b axis maintains homeostasis of adult hippocampal neurogenesis. Murao N, Matsuda T, Kadowaki H, Matsushita Y, Tanimoto K, Katagiri T, Nakashima K, Nishitoh H. EMBO Rep. 2024 Aug;25(8):3678-3706. doi: 10.1038/s44319-024-00205-7. Epub 2024 Jul 30. PubMed |
| SMARCA4 controls state plasticity in small cell lung cancer through regulation of neuroendocrine transcription factors and REST splicing. Redin E, Sridhar H, Zhan YA, Pereira Mello B, Zhong H, Durani V, Sabet A, Manoj P, Linkov I, Qiu J, Koche RP, de Stanchina E, Astorkia M, Betel D, Quintanal-Villalonga A, Rudin CM. J Hematol Oncol. 2024 Jul 30;17(1):58. doi: 10.1186/s13045-024-01572-3. PubMed |
| Sub-genomic flaviviral RNA elements increase the stability and abundance of recombinant AAV vector transcripts. Meganck RM, Ogurlu R, Liu J, Moller-Tank S, Tse V, Blondel LO, Rosales A, Hall AC, Vincent HA, Moorman NJ, Marzluff WF, Asokan A. J Virol. 2024 Aug 20;98(8):e0009524. doi: 10.1128/jvi.00095-24. Epub 2024 Jul 31. PubMed |
| SMYD5 is a regulator of the mild hypothermia response. Rafnsdottir S, Jang K, Halldorsdottir ST, Vinod M, Tomasdottir A, Moller K, Halldorsdottir K, Reynisdottir T, Atladottir LH, Allison KE, Ostacolo K, He J, Zhang L, Northington FJ, Magnusdottir E, Chavez-Valdez R, Anderson KJ, Bjornsson HT. Cell Rep. 2024 Aug 27;43(8):114554. doi: 10.1016/j.celrep.2024.114554. Epub 2024 Jul 30. PubMed |
| Protocol for establishing inducible CRISPR interference system for multiple-gene silencing in human pluripotent stem cells. Matsui S, Shiley JR, Granitto M, Ludwig K, Buckley M, Koigi S, Mirizio G, Hu YC, Mayhew CN, Iwafuchi M. STAR Protoc. 2024 Sep 20;5(3):103221. doi: 10.1016/j.xpro.2024.103221. Epub 2024 Jul 31. PubMed |
| RNA variant assessment using transactivation and transdifferentiation. Nicolas-Martinez EC, Robinson O, Pflueger C, Gardner A, Corbett MA, Ritchie T, Kroes T, van Eyk CL, Scheffer IE, Hildebrand MS, Barnier JV, Rousseau V, Genevieve D, Haushalter V, Piton A, Denomme-Pichon AS, Bruel AL, Nambot S, Isidor B, Grigg J, Gonzalez T, Ghedia S, Marchant RG, Bournazos A, Wong WK, Webster RI, Evesson FJ, Jones KJ, Cooper ST, Lister R, Gecz J, Jolly LA. Am J Hum Genet. 2024 Aug 8;111(8):1673-1699. doi: 10.1016/j.ajhg.2024.06.018. Epub 2024 Jul 30. PubMed |
| GDNF/GFRA1 signaling contributes to chemo- and radioresistance in glioblastoma. Avenel ICN, Ewald JD, Ariey-Bonnet J, Kristensen IH, Petterson SA, Thesbjerg MN, Burton M, Thomassen M, Wennerberg K, Michaelsen SR, Kristensen BW. Sci Rep. 2024 Jul 31;14(1):17639. doi: 10.1038/s41598-024-68626-x. PubMed |
| Inhibition of BCAT1-mediated cytosolic leucine metabolism regulates Th17 responses via the mTORC1-HIF1alpha pathway. Kang YJ, Song W, Lee SJ, Choi SA, Chae S, Yoon BR, Kim HY, Lee JH, Kim C, Cho JY, Kim HJ, Lee WW. Exp Mol Med. 2024 Aug;56(8):1776-1790. doi: 10.1038/s12276-024-01286-z. Epub 2024 Aug 1. PubMed |
| CRISPR perfect adaptation for robust control of cellular immune and apoptotic responses. Zhang Y, Zhang S. Nucleic Acids Res. 2024 Sep 9;52(16):10005-10016. doi: 10.1093/nar/gkae665. PubMed |
| Targeting Catechol-O-Methyltransferase Induces Mitochondrial Dysfunction and Enhances the Efficacy of Radiotherapy in Glioma. Jiao M, Pirozzi CJ, Yu C, Bao X, Hu M, Pan D, Littleton S, Reynolds N, Saban DR, Li F, Li CY. Cancer Res. 2024 Nov 4;84(21):3640-3656. doi: 10.1158/0008-5472.CAN-24-0134. PubMed |
| The BET PROTAC inhibitor GNE-987 displays anti-tumor effects by targeting super-enhancers regulated gene in osteosarcoma. Wu D, Yin H, Yang C, Zhang Z, Fang F, Wang J, Li X, Xie Y, Hu X, Zhuo R, Chen Y, Yu J, Li T, Li G, Pan J. BMC Cancer. 2024 Aug 1;24(1):928. doi: 10.1186/s12885-024-12691-y. PubMed |
| A platform to deliver single and bi-specific Cas9/guide RNA to perturb genes in vitro and in vivo. Li YJ, Chien SH, Huang R, Herrmann A, Zhao Q, Li PC, Zhang C, Martincuks A, Santiago NL, Zong K, Swiderski P, Okimoto RA, Song M, Rodriguez L, Forman SJ, Wang X, Yu H. Mol Ther. 2024 Oct 2;32(10):3629-3649. doi: 10.1016/j.ymthe.2024.07.025. Epub 2024 Jul 31. PubMed |
| UNC13B regulates the sensitivity of Wilms' tumor cells to doxorubicin by modulating lysosomes. Chen X, Bao Y, Sun G, Wang X, Zhu J. Oncol Lett. 2024 Jul 22;28(3):446. doi: 10.3892/ol.2024.14579. eCollection 2024 Sep. PubMed |
| Optimized reporters for multiplexed detection of transcription factor activity. Trauernicht M, Filipovska T, Rastogi C, van Steensel B. bioRxiv [Preprint]. 2024 Jul 26:2024.07.26.605239. doi: 10.1101/2024.07.26.605239. PubMed |
| A spectrum of clinically-identified cysteine mutations in fibulin-3 (EFEMP1) highlight its disulfide bonding complexity and potential to induce stress response activation. Collier GE, Hulleman JD. bioRxiv [Preprint]. 2024 Jul 23:2024.07.22.604634. doi: 10.1101/2024.07.22.604634. PubMed |
| Optogenetically modified human embryonic stem cell-derived otic neurons establish functional synaptic connection with cochlear nuclei. Chen Y, Mu W, Wu Y, Xu J, Li X, Hu H, Wang S, Wang D, Hui B, Wang L, Dong Y, Chen W. J Tissue Eng. 2024 Jul 31;15:20417314241265198. doi: 10.1177/20417314241265198. eCollection 2024 Jan-Dec. PubMed |
| SETDB1 suppresses NK cell-mediated immunosurveillance in acute myeloid leukemia with granulo-monocytic differentiation. Chang YH, Yamamoto K, Fujino T, Wang TW, Sugimoto E, Zhang W, Yabushita T, Suzaki K, Pietsch EC, Weir BA, Crescenzo R, Cowley GS, Attar R, Philippar U, Wunderlich M, Mizukawa B, Zheng Y, Enomoto Y, Imai Y, Kitamura T, Goyama S. Cell Rep. 2024 Aug 27;43(8):114536. doi: 10.1016/j.celrep.2024.114536. Epub 2024 Aug 2. PubMed |
| Targeting fatty acid oxidation enhances response to HER2-targeted therapy. Nandi I, Ji L, Smith HW, Avizonis D, Papavasiliou V, Lavoie C, Pacis A, Attalla S, Sanguin-Gendreau V, Muller WJ. Nat Commun. 2024 Aug 3;15(1):6587. doi: 10.1038/s41467-024-50998-3. PubMed |
| TERT upstream promoter methylation regulates TERT expression and acts as a therapeutic target in TERT promoter mutation-negative thyroid cancer. Li S, Hu G, Chen Y, Sang Y, Tang Q, Liu R. Cancer Cell Int. 2024 Aug 3;24(1):271. doi: 10.1186/s12935-024-03459-2. PubMed |
| Proximity labeling reveals dynamic changes in the SQSTM1 protein network. Rondon-Ortiz AN, Zhang L, Ash PEA, Basu A, Puri S, van der Spek SJF, Wang Z, Dorrian L, Emili A, Wolozin B. J Biol Chem. 2024 Sep;300(9):107621. doi: 10.1016/j.jbc.2024.107621. Epub 2024 Aug 3. PubMed |
Purinosomes spatially co-localize with mitochondrial transporters.
Sha Z, Benkovic SJ.
J Biol Chem. 2024 Aug 2;300(9):107620. doi: 10.1016/j.jbc.2024.107620.
PubMed
Associated Plasmids |
| Construction of an IFNAR1 knockout MDBK cell line using CRISPR/Cas9 and its effect on bovine virus replication. Geng Y, Jiang C, Yang H, Xia Q, Xu X, Yang K, Yuan X, Chen J, Chen Y, Chen X, Zhang L, Hu C, Guo A. Front Immunol. 2024 Jul 19;15:1404649. doi: 10.3389/fimmu.2024.1404649. eCollection 2024. PubMed |
| Single-cell sensor analyses reveal signaling programs enabling Ras-G12C drug resistance. Zhang JZ, Ong SE, Baker D, Maly DJ. Nat Chem Biol. 2025 Jan;21(1):47-58. doi: 10.1038/s41589-024-01684-4. Epub 2024 Aug 5. PubMed |
| Repurposing NAMPT Inhibitors for Germinal Center B Cell-Like Diffuse Large B-Cell Lymphoma. Scuoppo C, Cai B, Ofori K, Scholze H, Kumar R, D'Alessandro A, Basso K, Pasqualucci L, Dalla-Favera R. Blood Cancer Discov. 2024 Nov 1;5(6):417-427. doi: 10.1158/2643-3230.BCD-24-0020. PubMed |
| Colchicine-mediated selective autophagic degradation of HBV core proteins inhibits HBV replication and HBV-related hepatocellular carcinoma progression. Zhang H, Su X, Gu L, Tan M, Liu Y, Xu K, Ren J, Chen J, Li Z, Cheng S. Cell Death Discov. 2024 Aug 6;10(1):352. doi: 10.1038/s41420-024-02122-z. PubMed |
Programmable protein stabilization with language model-derived peptide guides.
Hong L, Ye T, Wang TZ, Srijay D, Zhao L, Watson R, Vincoff S, Chen T, Kholina K, Goel S, DeLisa MP, Chatterjee P.
Nat Commun. 2025 Apr 15;16(1):3555. doi: 10.1038/s41467-025-58872-6.
PubMed
Associated Plasmids |
| Actin networks modulate heterogeneous NF-kappaB dynamics in response to TNFalpha. Butera F, Sero JE, Dent LG, Bakal C. Elife. 2024 Aug 7;13:e86042. doi: 10.7554/eLife.86042. PubMed |
| Oncogenic transcription factors instruct promoter-enhancer hubs in individual triple negative breast cancer cells. Zhao J, Zhou Y, Tzelepis I, Burget NG, Shi J, Faryabi RB. Sci Adv. 2024 Aug 9;10(32):eadl4043. doi: 10.1126/sciadv.adl4043. Epub 2024 Aug 7. PubMed |
| Dopaminylation of endothelial TPI1 suppresses ferroptotic angiocrine signals to promote lung regeneration over fibrosis. Mo C, Li H, Yan M, Xu S, Wu J, Li J, Yang X, Li Y, Yang J, Su X, Liu J, Wu C, Wang Y, Dong H, Chen L, Dai L, Zhang M, Pu Q, Yang L, Ye T, Cao Z, Ding BS. Cell Metab. 2024 Aug 6;36(8):1839-1857.e12. doi: 10.1016/j.cmet.2024.07.008. PubMed |
| SYNGAP1 deficiency disrupts synaptic neoteny in xenotransplanted human cortical neurons in vivo. Vermaercke B, Iwata R, Wierda K, Boubakar L, Rodriguez P, Ditkowska M, Bonin V, Vanderhaeghen P. Neuron. 2024 Sep 25;112(18):3058-3068.e8. doi: 10.1016/j.neuron.2024.07.007. Epub 2024 Aug 6. PubMed |
| SNORD88B-mediated WRN nucleolar trafficking drives self-renewal in liver cancer initiating cells and hepatocarcinogenesis. Gu Y, Yi Z, Zhou Z, Wang J, Li S, Zhu P, Liu N, Xu Y, He L, Wang Y, Fan Z. Nat Commun. 2024 Aug 7;15(1):6730. doi: 10.1038/s41467-024-50987-6. PubMed |
| Exome-wide association study identifies KDELR3 mutations in extreme myopia. Yuan J, Zhuang YY, Liu X, Zhang Y, Li K, Chen ZJ, Li D, Chen H, Liang J, Yao Y, Yu X, Zhuo R, Zhao F, Zhou X, Yu X, Qu J, Su J. Nat Commun. 2024 Aug 7;15(1):6703. doi: 10.1038/s41467-024-50580-x. PubMed |
| Molecular mimicry in multisystem inflammatory syndrome in children. Bodansky A, Mettelman RC, Sabatino JJ Jr, Vazquez SE, Chou J, Novak T, Moffitt KL, Miller HS, Kung AF, Rackaityte E, Zamecnik CR, Rajan JV, Kortbawi H, Mandel-Brehm C, Mitchell A, Wang CY, Saxena A, Zorn K, Yu DJL, Pogorelyy MV, Awad W, Kirk AM, Asaki J, Pluvinage JV, Wilson MR, Zambrano LD, Campbell AP, Thomas PG, Randolph AG, Anderson MS, DeRisi JL. Nature. 2024 Aug;632(8025):622-629. doi: 10.1038/s41586-024-07722-4. Epub 2024 Aug 7. PubMed |
| GSK3 inhibition reduces ECM production and prevents age-related macular degeneration-like pathology. DiCesare SM, Ortega AJ, Collier GE, Daniel S, Thompson KN, McCoy MK, Posner BA, Hulleman JD. JCI Insight. 2024 Aug 8;9(15):e178050. doi: 10.1172/jci.insight.178050. PubMed |
| FDA-approved disulfiram inhibits the NLRP3 inflammasome by regulating NLRP3 palmitoylation. Xu J, Pickard JM, Nunez G. Cell Rep. 2024 Aug 27;43(8):114609. doi: 10.1016/j.celrep.2024.114609. Epub 2024 Aug 7. PubMed |
| TDP-43 dysfunction leads to bioenergetic failure and lipid metabolic rewiring in human cells. Ceron-Codorniu M, Torres P, Fernandez-Bernal A, Rico-Rios S, Serrano JC, Miralles MP, Beltran M, Garcera A, Soler RM, Pamplona R, Portero-Otin M. Redox Biol. 2024 Sep;75:103301. doi: 10.1016/j.redox.2024.103301. Epub 2024 Aug 5. PubMed |
| Sugar-mediated non-canonical ubiquitination impairs Nrf1/NFE2L1 activation. Yoshida Y, Takahashi T, Ishii N, Matsuo I, Takahashi S, Inoue H, Endo A, Tsuchiya H, Okada M, Ando C, Suzuki T, Dohmae N, Saeki Y, Tanaka K, Suzuki T. Mol Cell. 2024 Aug 22;84(16):3115-3127.e11. doi: 10.1016/j.molcel.2024.07.013. Epub 2024 Aug 7. PubMed |
| Histone-methyltransferase KMT2D deficiency impairs the Fanconi anemia/BRCA pathway upon glycolytic inhibition in squamous cell carcinoma. Liu W, Cao H, Wang J, Elmusrati A, Han B, Chen W, Zhou P, Li X, Keysar S, Jimeno A, Wang CY. Nat Commun. 2024 Aug 8;15(1):6755. doi: 10.1038/s41467-024-50861-5. PubMed |
| Oxysterole-binding protein targeted by SARS-CoV-2 viral proteins regulates coronavirus replication. Ma-Lauer Y, Li P, Niemeyer D, Richter A, Pusl K, von Brunn B, Ru Y, Xiang C, Schwinghammer S, Liu J, Baral P, Berthold EJ, Qiu H, Roy A, Kremmer E, Flaswinkel H, Drosten C, Jin Z, von Brunn A. Front Cell Infect Microbiol. 2024 Jul 25;14:1383917. doi: 10.3389/fcimb.2024.1383917. eCollection 2024. PubMed |
| The divergent effects of G3BP orthologs on human stress granule assembly imply a centric role for the core protein interaction network. Yao Z, Liu Y, Chen Q, Chen X, Zhu Z, Song S, Ma X, Yang P. Cell Rep. 2024 Aug 27;43(8):114617. doi: 10.1016/j.celrep.2024.114617. Epub 2024 Aug 8. PubMed |
| Enhancing homology-directed repair efficiency with HDR-boosting modular ssDNA donor. Jin YY, Zhang P, Liu LL, Zhao X, Hu XQ, Liu SZ, Li ZK, Liu Q, Wang JQ, Hao DL, Zhang ZQ, Chen HZ, Liu DP. Nat Commun. 2024 Aug 10;15(1):6843. doi: 10.1038/s41467-024-50788-x. PubMed |
Proximity analysis of native proteomes reveals phenotypic modifiers in a mouse model of autism and related neurodevelopmental conditions.
Gao Y, Shonai D, Trn M, Zhao J, Soderblom EJ, Garcia-Moreno SA, Gersbach CA, Wetsel WC, Dawson G, Velmeshev D, Jiang YH, Sloofman LG, Buxbaum JD, Soderling SH.
Nat Commun. 2024 Aug 9;15(1):6801. doi: 10.1038/s41467-024-51037-x.
PubMed
Associated Plasmids |
| CHD4 R975H mutant activates tumorigenic pathways and promotes stemness and M2-like macrophage polarization in endometrial cancer. Zhang Q, Zhu F, Tong Y, Shi D, Zhang J. Sci Rep. 2024 Aug 10;14(1):18617. doi: 10.1038/s41598-024-69233-6. PubMed |
| CD177 is a novel IgG Fc receptor and CD177 genetic variants affect IgG-mediated function. Li Y, Wu J. Front Immunol. 2024 Jul 26;15:1418539. doi: 10.3389/fimmu.2024.1418539. eCollection 2024. PubMed |
| Protocol for establishing inducible CRISPRd system for blocking transcription factor-binding sites in human pluripotent stem cells. Matsui S, Shiley JR, Buckley M, Lim HW, Hu YC, Mayhew CN, Iwafuchi M. STAR Protoc. 2024 Sep 20;5(3):103233. doi: 10.1016/j.xpro.2024.103233. Epub 2024 Aug 11. PubMed |
| Strong capacity of differentiated PD-L1 CAR-modified UCB-CD34(+) cells and PD-L1 CAR-modified UCB-CD34(+)-derived NK cells in killing target cells and restoration of the anti-tumor function of PD-1-high exhausted T Cells. Ghaedrahmati F, Akbari V, Seyedhosseini-Ghaheh H, Esmaeil N. Stem Cell Res Ther. 2024 Aug 13;15(1):257. doi: 10.1186/s13287-024-03871-5. PubMed |
| A potential therapeutic strategy based on acute oxidative stress induction for wild-type NRF2/KEAP1 lung squamous cell carcinoma. Sanchez-Ortega M, Garrido A, Cirauqui C, Sanz-Gonzalez L, Hernandez MC, Gonzalez-Garcia A, Obregon K, Ferrer I, Paz-Ares L, Carrera AC. Redox Biol. 2024 Sep;75:103305. doi: 10.1016/j.redox.2024.103305. Epub 2024 Aug 8. PubMed |
| SARS-CoV-2 N protein-induced Dicer, XPO5, SRSF3, and hnRNPA3 downregulation causes pneumonia. Luo YW, Zhou JP, Ji H, Xu D, Zheng A, Wang X, Dai Z, Luo Z, Cao F, Wang XY, Bai Y, Chen D, Chen Y, Wang Q, Yang Y, Zhang X, Chiu S, Peng X, Huang AL, Tang KF. Nat Commun. 2024 Aug 13;15(1):6964. doi: 10.1038/s41467-024-51192-1. PubMed |
| Polyomavirus ALTOs, but not MTs, downregulate viral early gene expression by activating the NF-kappaB pathway. Salisbury NJH, Amonkar S, Landazuri Vinueza J, Carter JJ, Roman A, Galloway DA. Proc Natl Acad Sci U S A. 2024 Aug 20;121(34):e2403133121. doi: 10.1073/pnas.2403133121. Epub 2024 Aug 14. PubMed |
| Primate-specific BTN3A2 protects against SARS-CoV-2 infection by interacting with and reducing ACE2. Xu L, Yu D, Xu M, Liu Y, Yang LX, Zou QC, Feng XL, Li MH, Sheng N, Yao YG. EBioMedicine. 2024 Sep;107:105281. doi: 10.1016/j.ebiom.2024.105281. Epub 2024 Aug 13. PubMed |
| OPA1 promotes ferroptosis by augmenting mitochondrial ROS and suppressing an integrated stress response. Liang FG, Zandkarimi F, Lee J, Axelrod JL, Pekson R, Yoon Y, Stockwell BR, Kitsis RN. Mol Cell. 2024 Aug 22;84(16):3098-3114.e6. doi: 10.1016/j.molcel.2024.07.020. Epub 2024 Aug 13. PubMed |
| HLTF resolves G4s and promotes G4-induced replication fork slowing to maintain genome stability. Bai G, Endres T, Kuhbacher U, Mengoli V, Greer BH, Peacock EM, Newton MD, Stanage T, Dello Stritto MR, Lungu R, Crossley MP, Sathirachinda A, Cortez D, Boulton SJ, Cejka P, Eichman BF, Cimprich KA. Mol Cell. 2024 Aug 22;84(16):3044-3060.e11. doi: 10.1016/j.molcel.2024.07.018. Epub 2024 Aug 13. PubMed |
| Generation of a conditional cellular senescence model using proximal tubule cells and fibroblasts from human kidneys. Shao X, Xu H, Kim H, Ljaz S, Beier F, Jankowski V, Lellig M, Vankann L, Werner JN, Chen L, Ziegler S, Kuppe C, Zenke M, Schneider RK, Hayat S, Saritas T, Kramann R. Cell Death Discov. 2024 Aug 14;10(1):364. doi: 10.1038/s41420-024-02131-y. PubMed |
| Satellite cell-derived TRIM28 is pivotal for mechanical load- and injury-induced myogenesis. Lin KH, Hibbert JE, Flynn CG, Lemens JL, Torbey MM, Steinert ND, Flejsierowicz PM, Melka KM, Lindley GT, Lares M, Setaluri V, Wagers AJ, Hornberger TA. EMBO Rep. 2024 Sep;25(9):3812-3841. doi: 10.1038/s44319-024-00227-1. Epub 2024 Aug 14. PubMed |
| The epithelial Na(+) channel (ENaC) in ovarian granulosa cells modulates Ca(2+) mobilization and gonadotrophin signaling for estrogen homeostasis and female fertility. Ma X, Xu R, Chen J, Wang S, Hu P, Wu Y, Que Y, Du W, Cai X, Chen H, Guo J, Li TC, Ruan YC. Cell Commun Signal. 2024 Aug 14;22(1):398. doi: 10.1186/s12964-024-01778-5. PubMed |
| A primate-specific endogenous retroviral envelope protein sequesters SFRP2 to regulate human cardiomyocyte development. Zhang R, Wu M, Xiang D, Zhu J, Zhang Q, Zhong H, Peng Y, Wang Z, Ma G, Li G, Liu F, Ye W, Shi R, Zhou X, Babarinde IA, Su H, Chen J, Zhang X, Qin D, Hutchins AP, Pei D, Li D. Cell Stem Cell. 2024 Sep 5;31(9):1298-1314.e8. doi: 10.1016/j.stem.2024.07.006. Epub 2024 Aug 14. PubMed |
| Evolutionary and functional analyses reveal a role for the RHIM in tuning RIPK3 activity across vertebrates. Fay EJ, Isterabadi K, Rezanka CM, Le J, Daugherty MD. bioRxiv [Preprint]. 2025 Jan 31:2024.05.09.593370. doi: 10.1101/2024.05.09.593370. PubMed |
| TBK1 and IKKepsilon protect target cells from IFNgamma-mediated T cell killing via an inflammatory apoptotic mechanism. Sun ND, Carr AR, Krogman EN, Chawla Y, Zhong J, Guttormson MC, Chan M, Hsu MA, Dong H, Bogunovic D, Pandey A, Rogers LM, Ting AT. bioRxiv [Preprint]. 2024 Aug 8:2024.08.06.606693. doi: 10.1101/2024.08.06.606693. PubMed |
| Translation efficiency covariation across cell types is a conserved organizing principle of mammalian transcriptomes. Liu Y, Rao S, Hoskins I, Geng M, Zhao Q, Chacko J, Ghatpande V, Qi K, Persyn L, Wang J, Zheng D, Zhong Y, Park D, Cenik ES, Agarwal V, Ozadam H, Cenik C. bioRxiv [Preprint]. 2025 Jan 18:2024.08.11.607360. doi: 10.1101/2024.08.11.607360. PubMed |
| An enhanced Eco1 retron editor enables precision genome engineering in human cells from a single-copy integrated lentivirus. Cattle MA, Aguado LC, Sze S, Wang DY, Papagiannakopoulos T, Smith S, Rice CM, Schneider WM, Poirier JT. bioRxiv [Preprint]. 2024 Aug 7:2024.08.05.606586. doi: 10.1101/2024.08.05.606586. PubMed |
| A high-throughput microfabricated platform for rapid quantification of metastatic potential. Bhattacharya S, Ettela A, Haydak J, Hobson CM, Stern A, Yoo M, Chew TL, Gusella GL, Gallagher EJ, Hone JC, Azeloglu EU. Sci Adv. 2024 Aug 16;10(33):eadk0015. doi: 10.1126/sciadv.adk0015. Epub 2024 Aug 16. PubMed |
| SelK promotes glioblastoma cell proliferation by inhibiting beta-TrCP1 mediated ubiquitin-dependent degradation of CDK4. Li J, Zhao L, Wu Z, Huang S, Wang J, Chang Y, Liu L, Jin H, Lu J, Huang C, Xie Q, Huang H, Su Z. J Exp Clin Cancer Res. 2024 Aug 19;43(1):231. doi: 10.1186/s13046-024-03157-x. PubMed |
| An i-motif-regulated enhancer, eRNA and adjacent lncRNA affect Lhb expression through distinct mechanisms in a sex-specific context. Refael T, Sudman M, Golan G, Pnueli L, Naik S, Preger-Ben Noon E, Henn A, Kaplan A, Melamed P. Cell Mol Life Sci. 2024 Aug 19;81(1):361. doi: 10.1007/s00018-024-05398-7. PubMed |
| CRISPR screening uncovers a long-range enhancer for ONECUT1 in pancreatic differentiation and links a diabetes risk variant. Kaplan SJ, Wong W, Yan J, Pulecio J, Cho HS, Li Q, Zhao J, Leslie-Iyer J, Kazakov J, Murphy D, Luo R, Dey KK, Apostolou E, Leslie CS, Huangfu D. Cell Rep. 2024 Aug 27;43(8):114640. doi: 10.1016/j.celrep.2024.114640. Epub 2024 Aug 21. PubMed |
| Influenza vaccination stimulates maturation of the human T follicular helper cell response. Schattgen SA, Turner JS, Ghonim MA, Crawford JC, Schmitz AJ, Kim H, Zhou JQ, Awad W, Mettelman RC, Kim W, McIntire KM, Haile A, Klebert MK, Suessen T, Middleton WD, Teefey SA, Presti RM, Ellebedy AH, Thomas PG. Nat Immunol. 2024 Sep;25(9):1742-1753. doi: 10.1038/s41590-024-01926-6. Epub 2024 Aug 20. PubMed |
| Engineered mitochondria exert potent antitumor immunity as a cancer vaccine platform. Luo J, Mo F, Zhang Z, Hong W, Lan T, Cheng Y, Fang C, Bi Z, Qin F, Yang J, Zhang Z, Li X, Que H, Wang J, Chen S, Wu Y, Yang L, Li J, Wang W, Chen C, Wei X. Cell Mol Immunol. 2024 Nov;21(11):1251-1265. doi: 10.1038/s41423-024-01203-4. Epub 2024 Aug 20. PubMed |
| Soluble Tim-3 serves as a tumor prognostic marker and therapeutic target for CD8(+) T cell exhaustion and anti-PD-1 resistance. Chen C, Zhao F, Peng J, Zhao D, Xu L, Li H, Ma S, Peng X, Sheng X, Sun Y, Wang T, Dong H, Ding Y, Wu Z, Liang X, Gao L, Wang H, Ma C, Li C. Cell Rep Med. 2024 Aug 20;5(8):101686. doi: 10.1016/j.xcrm.2024.101686. PubMed |
| Time-of-day effects of cancer drugs revealed by high-throughput deep phenotyping. Ector C, Schmal C, Didier J, De Landtsheer S, Finger AM, Muller-Marquardt F, Schulte JH, Sauter T, Keilholz U, Herzel H, Kramer A, Granada AE. Nat Commun. 2024 Aug 22;15(1):7205. doi: 10.1038/s41467-024-51611-3. PubMed |
| RNA interacts with topoisomerase I to adjust DNA topology. Bhola M, Abe K, Orozco P, Rahnamoun H, Avila-Lopez P, Taylor E, Muhammad N, Liu B, Patel P, Marko JF, Starner AC, He C, Van Nostrand EL, Mondragon A, Lauberth SM. Mol Cell. 2024 Sep 5;84(17):3192-3208.e11. doi: 10.1016/j.molcel.2024.07.032. Epub 2024 Aug 21. PubMed |
| Role of a holo-insertase complex in the biogenesis of biophysically diverse ER membrane proteins. Page KR, Nguyen VN, Pleiner T, Tomaleri GP, Wang ML, Guna A, Hazu M, Wang TY, Chou TF, Voorhees RM. Mol Cell. 2024 Sep 5;84(17):3302-3319.e11. doi: 10.1016/j.molcel.2024.08.005. Epub 2024 Aug 21. PubMed |
| A novel lncRNA GM47544 modulates triglyceride metabolism by inducing ubiquitination-dependent protein degradation of APOC3. Xiao Q, Wang L, Wang J, Wang M, Wang DW, Ding H. Mol Metab. 2024 Oct;88:102011. doi: 10.1016/j.molmet.2024.102011. Epub 2024 Aug 20. PubMed |
| Targeting Gsk3a reverses immune evasion to enhance immunotherapy in hepatocellular carcinoma. Zheng X, Yang L, Shen X, Pan J, Chen Y, Chen J, Wang H, Meng J, Chen Z, Xie S, Li Y, Zhu B, Zhu W, Qin L, Lu L. J Immunother Cancer. 2024 Aug 21;12(8):e009642. doi: 10.1136/jitc-2024-009642. PubMed |
| EZH2 represses mesenchymal genes and upholds the epithelial state of breast carcinoma cells. Gallardo A, Lopez-Onieva L, Belmonte-Reche E, Fernandez-Rengel I, Serrano-Prados A, Molina A, Sanchez-Pozo A, Landeira D. Cell Death Dis. 2024 Aug 22;15(8):609. doi: 10.1038/s41419-024-07011-y. PubMed |
| Specific multivalent molecules boost CRISPR-mediated transcriptional activation. Chen R, Shi X, Yao X, Gao T, Huang G, Ning D, Cao Z, Xu Y, Liang W, Tian SZ, Zhu Q, Fang L, Zheng M, Hu Y, Cui H, Chen W. Nat Commun. 2024 Aug 22;15(1):7222. doi: 10.1038/s41467-024-51694-y. PubMed |
| A plug-and-play monofunctional platform for targeted degradation of extracellular proteins and vesicles. Yao S, Wang Y, Tang Q, Yin Y, Geng Y, Xu L, Liang S, Xiang J, Fan J, Tang J, Liu J, Shao S, Shen Y. Nat Commun. 2024 Aug 22;15(1):7237. doi: 10.1038/s41467-024-51720-z. PubMed |
| Alveolar epithelial cells mitigate neutrophilic inflammation in lung injury through regulating mitochondrial fatty acid oxidation. Chung KP, Cheng CN, Chen YJ, Hsu CL, Huang YL, Hsieh MS, Kuo HC, Lin YT, Juan YH, Nakahira K, Chen YF, Liu WL, Ruan SY, Chien JY, Plataki M, Cloonan SM, Carmeliet P, Choi AMK, Kuo CH, Yu CJ. Nat Commun. 2024 Aug 22;15(1):7241. doi: 10.1038/s41467-024-51683-1. PubMed |
| ACAD10 and ACAD11 allow entry of 4-hydroxy fatty acids into beta-oxidation. Paquay S, Duraffourd J, Bury M, Heremans IP, Caligiore F, Gerin I, Stroobant V, Jacobs J, Pinon A, Graff J, Vertommen D, Van Schaftingen E, Dewulf JP, Bommer GT. Cell Mol Life Sci. 2024 Aug 22;81(1):367. doi: 10.1007/s00018-024-05397-8. PubMed |
| CRISPR-Cas9 screening develops an epigenetic and transcriptional gene signature for risk stratification and target prediction in neuroblastoma. Zhang L, Mo J, Shi H, Xiong J, Aierken Y, Chen F, Tang Y, Zhao K, Lv Z, Tan K. Front Cell Dev Biol. 2024 Aug 8;12:1433008. doi: 10.3389/fcell.2024.1433008. eCollection 2024. PubMed |
| Association with TFIIIC limits MYCN localisation in hubs of active promoters and chromatin accumulation of non-phosphorylated RNA polymerase II. Vidal R, Leen E, Herold S, Muller M, Fleischhauer D, Schulein-Volk C, Papadopoulos D, Roschert I, Uhl L, Ade CP, Gallant P, Bayliss R, Eilers M, Buchel G. Elife. 2024 Aug 23;13:RP94407. doi: 10.7554/eLife.94407. PubMed |
| CRISPR screening identifies PRMT1 as a key pro-ferroptotic gene via a two-layer regulatory mechanism. Zhang X, Duan Y, Li S, Zhang Z, Peng L, Ma X, Wang T, Xiang S, Chen G, Zhou D, Lu D, Qian M, Wang Z. Cell Rep. 2024 Sep 24;43(9):114662. doi: 10.1016/j.celrep.2024.114662. Epub 2024 Aug 22. PubMed |
| Comparative time-series multi-omics analyses suggest H1.2 involvement in anoxic adaptation and cancer resistance. Du J, Liu W, Li M, Li Z, Li X, Dai Y, Liu G, Wang X, Zhu P, Gladyshev VN, Zhou X. PLoS Biol. 2024 Aug 23;22(8):e3002778. doi: 10.1371/journal.pbio.3002778. eCollection 2024 Aug. PubMed |
| Histone chaperone HIRA, promyelocytic leukemia protein, and p62/SQSTM1 coordinate to regulate inflammation during cell senescence. Dasgupta N, Lei X, Shi CH, Arnold R, Teneche MG, Miller KN, Rajesh A, Davis A, Anschau V, Campos AR, Gilson R, Havas A, Yin S, Chua ZM, Liu T, Proulx J, Alcaraz M, Rather MI, Baeza J, Schultz DC, Yip KY, Berger SL, Adams PD. Mol Cell. 2024 Sep 5;84(17):3271-3287.e8. doi: 10.1016/j.molcel.2024.08.006. Epub 2024 Aug 22. PubMed |
| Lipid synthesis, triggered by PPARgamma T166 dephosphorylation, sustains reparative function of macrophages during tissue repair. Zuo S, Wang Y, Bao H, Zhang Z, Yang N, Jia M, Zhang Q, Jian A, Ji R, Zhang L, Lu Y, Huang Y, Shen P. Nat Commun. 2024 Aug 23;15(1):7269. doi: 10.1038/s41467-024-51736-5. PubMed |
| Neuroprotective Effects of VGLUT1 Inhibition in HT22 Cells Overexpressing VGLUT1 Under Oxygen Glucose Deprivation Conditions. Pomierny B, Krzyzanowska W, Skorkowska A, Budziszewska B, Pera J. Neuromolecular Med. 2024 Aug 23;26(1):35. doi: 10.1007/s12017-024-08803-3. PubMed |
| Knockout of the WD40 domain of ATG16L1 enhances foot and mouth disease virus replication. Wu X, Yang Y, Ru Y, Hao R, Zhao D, Ren R, Lu B, Li Y, Sun S, Zheng H, Wang W. BMC Genomics. 2024 Aug 23;25(1):796. doi: 10.1186/s12864-024-10703-6. PubMed |
| Immune suppression by human thymus-derived effector Tregs relies on glucose/lactate-fueled fatty acid synthesis. de Kivit S, Mensink M, Kostidis S, Derks RJE, Zaal EA, Heijink M, Verleng LJ, de Vries E, Schrama E, Blomberg N, Berkers CR, Giera M, Borst J. Cell Rep. 2024 Sep 24;43(9):114681. doi: 10.1016/j.celrep.2024.114681. Epub 2024 Aug 23. PubMed |
| RAD21 promotes oncogenesis and lethal progression of prostate cancer. Su XA, Stopsack KH, Schmidt DR, Ma D, Li Z, Scheet PA, Penney KL, Lotan TL, Abida W, DeArment EG, Lu K, Janas T, Hu S, Vander Heiden MG, Loda M, Boselli M, Amon A, Mucci LA. Proc Natl Acad Sci U S A. 2024 Sep 3;121(36):e2405543121. doi: 10.1073/pnas.2405543121. Epub 2024 Aug 27. PubMed |
Engineering acyclovir-induced RNA nanodevices for reversible and tunable control of aptamer function.
Hagen T, Litke JL, Nasir N, Hou Q, Jaffrey SR.
Cell Chem Biol. 2024 Aug 23:S2451-9456(24)00319-2. doi: 10.1016/j.chembiol.2024.07.017.
PubMed
Associated Plasmids |
| The PARP inhibitor rucaparib blocks SARS-CoV-2 virus binding to cells and the immune reaction in models of COVID-19. Papp H, Toth E, Bovari-Biri J, Banfai K, Juhasz P, Mahdi M, Russo LC, Bajusz D, Sipos A, Petri L, Szalai TV, Kemeny A, Madai M, Kuczmog A, Batta G, Mozner O, Vasko D, Hirsch E, Bohus P, Mehes G, Tozser J, Curtin NJ, Helyes Z, Toth A, Hoch NC, Jakab F, Keseru GM, Pongracz JE, Bai P. Br J Pharmacol. 2024 Dec;181(23):4782-4803. doi: 10.1111/bph.17305. Epub 2024 Aug 27. PubMed |
| Tumor-associated macrophage-derived itaconic acid contributes to nasopharyngeal carcinoma progression by promoting immune escape via TET2. Zhang X, Qian S, Wu P, Yu B, Yin D, Peng X, Li S, Xiao Z, Xie Z. Cell Commun Signal. 2024 Aug 27;22(1):413. doi: 10.1186/s12964-024-01799-0. PubMed |
| Identification and Characterization of Novel Small-Molecule Enhancers of the CUL3(LZTR1) E3 Ligase KRAS Complex. Piech S, Bruschweiler S, Westphalen J, Siess KM, Garcia Murias J, Konrat R, Bigenzahn JW, Superti-Furga G. ACS Chem Biol. 2024 Sep 20;19(9):1942-1952. doi: 10.1021/acschembio.4c00077. Epub 2024 Aug 28. PubMed |
| Inhibition of TOPORS ubiquitin ligase augments the efficacy of DNA hypomethylating agents through DNMT1 stabilization. Kaito S, Aoyama K, Oshima M, Tsuchiya A, Miyota M, Yamashita M, Koide S, Nakajima-Takagi Y, Kozuka-Hata H, Oyama M, Yogo T, Yabushita T, Ito R, Ueno M, Hirao A, Tohyama K, Li C, Kawabata KC, Yamaguchi K, Furukawa Y, Kosako H, Yoshimi A, Goyama S, Nannya Y, Ogawa S, Agger K, Helin K, Yamazaki S, Koseki H, Doki N, Harada Y, Harada H, Nishiyama A, Nakanishi M, Iwama A. Nat Commun. 2024 Aug 28;15(1):7359. doi: 10.1038/s41467-024-50498-4. PubMed |
| TOPORS E3 ligase mediates resistance to hypomethylating agent cytotoxicity in acute myeloid leukemia cells. Truong P, Shen S, Joshi S, Islam MI, Zhong L, Raftery MJ, Afrasiabi A, Alinejad-Rokny H, Nguyen M, Zou X, Bhuyan GS, Sarowar CH, Ghodousi ES, Stonehouse O, Mohamed S, Toscan CE, Connerty P, Kakadia PM, Bohlander SK, Michie KA, Larsson J, Lock RB, Walkley CR, Thoms JAI, Jolly CJ, Pimanda JE. Nat Commun. 2024 Aug 28;15(1):7360. doi: 10.1038/s41467-024-51646-6. PubMed |
| Tuberculosis in otherwise healthy adults with inherited TNF deficiency. Arias AA, Neehus AL, Ogishi M, Meynier V, Krebs A, Lazarov T, Lee AM, Arango-Franco CA, Yang R, Orrego J, Corcini Berndt M, Rojas J, Li H, Rinchai D, Erazo-Borras L, Han JE, Pillay B, Ponsin K, Chaldebas M, Philippot Q, Bohlen J, Rosain J, Le Voyer T, Janotte T, Amarajeeva K, Soudee C, Brollo M, Wiegmann K, Marquant Q, Seeleuthner Y, Lee D, Laine C, Kloos D, Bailey R, Bastard P, Keating N, Rapaport F, Khan T, Moncada-Velez M, Carmona MC, Obando C, Alvarez J, Catano JC, Martinez-Rosado LL, Sanchez JP, Tejada-Giraldo M, L'Honneur AS, Agudelo ML, Perez-Zapata LJ, Arboleda DM, Alzate JF, Cabarcas F, Zuluaga A, Pelham SJ, Ensser A, Schmidt M, Velasquez-Lopera MM, Jouanguy E, Puel A, Kronke M, Ghirardello S, Borghesi A, Pahari S, Boisson B, Pittaluga S, Ma CS, Emile JF, Notarangelo LD, Tangye SG, Marr N, Lachmann N, Salvator H, Schlesinger LS, Zhang P, Glickman MS, Nathan CF, Geissmann F, Abel L, Franco JL, Bustamante J, Casanova JL, Boisson-Dupuis S. Nature. 2024 Sep;633(8029):417-425. doi: 10.1038/s41586-024-07866-3. Epub 2024 Aug 28. PubMed |
| Pharmacogenomic discovery of genetically targeted cancer therapies optimized against clinical outcomes. Truesdell P, Chang J, Coto Villa D, Dai M, Zhao Y, McIlwain R, Young S, Hiley S, Craig AW, Babak T. NPJ Precis Oncol. 2024 Aug 28;8(1):186. doi: 10.1038/s41698-024-00673-z. PubMed |
| The RNA Demethylases ALKBH5 and FTO Regulate the Translation of ATF4 mRNA in Sorafenib-Treated Hepatocarcinoma Cells. Adjibade P, Di-Marco S, Gallouzi IE, Mazroui R. Biomolecules. 2024 Aug 1;14(8):932. doi: 10.3390/biom14080932. PubMed |
| Doxycycline-Mediated Control of Cyclin D2 Overexpression in Human-Induced Pluripotent Stem Cells. Qiao A, Wei Y, Liu Y, Kahn-Krell A, Ye L, Nguyen T, Zhang J. Int J Mol Sci. 2024 Aug 9;25(16):8714. doi: 10.3390/ijms25168714. PubMed |
| Development of a Bmi1+ Cardiac Mouse Progenitor Immortalized Model to Unravel the Relationship with Its Protective Vascular Endothelial Niche. Albericio G, Higuera M, Araque P, Sanchez C, Herrero D, Garcia-Brenes MA, Formentini L, Toran JL, Mora C, Bernad A. Int J Mol Sci. 2024 Aug 13;25(16):8815. doi: 10.3390/ijms25168815. PubMed |
| Hsp70 Negatively Regulates Autophagy via Governing AMPK Activation, and Dual Hsp70-Autophagy Inhibition Induces Synergetic Cell Death in NSCLC Cells. Alhasan B, Gladova YA, Sverchinsky DV, Aksenov ND, Margulis BA, Guzhova IV. Int J Mol Sci. 2024 Aug 22;25(16):9090. doi: 10.3390/ijms25169090. PubMed |
| MOF-mediated PRDX1 acetylation regulates inflammatory macrophage activation. Chen HR, Sun Y, Mittler G, Rumpf T, Shvedunova M, Grosschedl R, Akhtar A. Cell Rep. 2024 Sep 24;43(9):114682. doi: 10.1016/j.celrep.2024.114682. Epub 2024 Aug 28. PubMed |
| The ULK1 effector BAG2 regulates autophagy initiation by modulating AMBRA1 localization. Sankar DS, Kaeser-Pebernard S, Vionnet C, Favre S, de Oliveira Marchioro L, Pillet B, Zhou J, Stumpe M, Kovacs WJ, Kressler D, Antonioli M, Fimia GM, Dengjel J. Cell Rep. 2024 Sep 24;43(9):114689. doi: 10.1016/j.celrep.2024.114689. Epub 2024 Aug 27. PubMed |
| PD-1 signaling limits expression of phospholipid phosphatase 1 and promotes intratumoral CD8(+) T cell ferroptosis. Ping Y, Shan J, Qin H, Li F, Qu J, Guo R, Han D, Jing W, Liu Y, Liu J, Liu Z, Li J, Yue D, Wang F, Wang L, Zhang B, Huang B, Zhang Y. Immunity. 2024 Sep 10;57(9):2122-2139.e9. doi: 10.1016/j.immuni.2024.08.003. Epub 2024 Aug 28. PubMed |
| Mannose receptor (MRC1) mediates uptake of dextran in macrophages via receptor-mediated endocytosis. Wollman J, Wanniarachchi K, Pradhan B, Huang L, Kerkvliet JG, Hoppe AD, Thiex NW. bioRxiv [Preprint]. 2024 Aug 13:2024.08.13.607841. doi: 10.1101/2024.08.13.607841. PubMed |
| Inhibition of ULK1/2 and KRAS(G12C) controls tumor growth in preclinical models of lung cancer. Ghazi PC, O'Toole KT, Srinivas Boggaram S, Scherzer MT, Silvis MR, Zhang Y, Bogdan M, Smith BD, Lozano G, Flynn DL, Snyder EL, Kinsey CG, McMahon M. Elife. 2024 Aug 30;13:RP96992. doi: 10.7554/eLife.96992. PubMed |
| CD14 is a decision-maker between Fas-mediated death and inflammation. Magri Z, Jetton D, Muendlein HI, Connolly WM, Russell H, Smirnova I, Sharma S, Bunnell S, Poltorak A. Cell Rep. 2024 Sep 24;43(9):114685. doi: 10.1016/j.celrep.2024.114685. Epub 2024 Aug 30. PubMed |
| Rab27a GTPase and its effector Myosin Va are host factors required for efficient Oropouche virus cell egress. Concha JO, Gutierrez K, Barbosa N, Rodrigues RL, de Carvalho AN, Tavares LA, Rudd JS, Costa CS, Andrade BYG, Espreafico EM, Crump CM, daSilva LLP. PLoS Pathog. 2024 Aug 30;20(8):e1012504. doi: 10.1371/journal.ppat.1012504. eCollection 2024 Aug. PubMed |
| A bispecific antibody targeting EGFR and AXL delays resistance to osimertinib. Simoni-Nieves A, Lindzen M, Giri S, Gupta N, Chatterjee R, Selvadurai BR, Van Daele M, Love D, Haga Y, Romaniello D, Salame TM, Zerbib M, Oren R, Tsutsumi Y, Lauriola M, Marrocco I, Yarden Y. Cell Rep Med. 2024 Sep 17;5(9):101703. doi: 10.1016/j.xcrm.2024.101703. Epub 2024 Aug 30. PubMed |
| Pharmacological chaperones restore proteostasis of epilepsy-associated GABA(A) receptor variants. Wang YJ, Seibert H, Ahn LY, Schaffer AE, Mu TW. Pharmacol Res. 2024 Oct;208:107356. doi: 10.1016/j.phrs.2024.107356. Epub 2024 Aug 30. PubMed |
| Multi-omic lineage tracing predicts the transcriptional, epigenetic and genetic determinants of cancer evolution. Nadalin F, Marzi MJ, Pirra Piscazzi M, Fuentes-Bravo P, Procaccia S, Climent M, Bonetti P, Rubolino C, Giuliani B, Papatheodorou I, Marioni JC, Nicassio F. Nat Commun. 2024 Sep 1;15(1):7609. doi: 10.1038/s41467-024-51424-4. PubMed |
| Integrin alpha2 is an early marker for osteoclast differentiation that contributes to key steps in osteoclastogenesis. Brockhaus K, Hemsen I, Jauch-Speer SL, Niland S, Vogl T, Eble JA. Front Cell Dev Biol. 2024 Aug 15;12:1448725. doi: 10.3389/fcell.2024.1448725. eCollection 2024. PubMed |
| Direct detection of endogenous Galphai activity in cells with a sensitive conformational biosensor. Luebbers A, Janicot R, Zhao J, Philibert CE, Garcia-Marcos M. bioRxiv [Preprint]. 2024 Aug 22:2024.08.21.609006. doi: 10.1101/2024.08.21.609006. PubMed |
| RBN-2397, a PARP7 Inhibitor, Synergizes with Paclitaxel to Inhibit Proliferation and Migration of Ovarian Cancer Cells. Spirtos AN, Aljardali MW, Challa S, Koul S, Lea JS, Kraus WL, Camacho CV. bioRxiv [Preprint]. 2024 Sep 5:2024.08.20.608802. doi: 10.1101/2024.08.20.608802. PubMed |
| The SWI/SNF PBAF complex facilitates REST occupancy at repressive chromatin. Grossi E, Nguyen CB, Carcamo S, Moran S, Callau VK, Filipescu D, Hasson D, Bernstein E. bioRxiv [Preprint]. 2024 Aug 23:2024.08.23.609212. doi: 10.1101/2024.08.23.609212. PubMed |
| Restraint of melanoma progression by cells in the local skin environment. Ma Y, Tagore M, Hunter MV, Huang TH, Montal E, Weiss JM, White RM. bioRxiv [Preprint]. 2024 Aug 19:2024.08.15.608067. doi: 10.1101/2024.08.15.608067. PubMed |
| Robust Double Emulsions for Multicolor Fluorescence-Activated Cell Sorting. Ding Y, Zoppi G, Antonini G, Geiger R, deMello AJ. Anal Chem. 2024 Sep 17;96(37):14809-14818. doi: 10.1021/acs.analchem.4c02363. Epub 2024 Sep 4. PubMed |
| Endothelial gamma-protocadherins inhibit KLF2 and KLF4 to promote atherosclerosis. Joshi D, Coon BG, Chakraborty R, Deng H, Yang Z, Babar MU, Fernandez-Tussy P, Meredith E, Attanasio J, Joshi N, Traylor JG Jr, Orr AW, Fernandez-Hernando C, Libreros S, Schwartz MA. Nat Cardiovasc Res. 2024 Sep;3(9):1035-1048. doi: 10.1038/s44161-024-00522-z. Epub 2024 Sep 4. PubMed |
| GABAergic neuronal lineage development determines clinically actionable targets in diffuse hemispheric glioma, H3G34-mutant. Liu I, Alencastro Veiga Cruzeiro G, Bjerke L, Rogers RF, Grabovska Y, Beck A, Mackay A, Barron T, Hack OA, Quezada MA, Molinari V, Shaw ML, Perez-Somarriba M, Temelso S, Raynaud F, Ruddle R, Panditharatna E, Englinger B, Mire HM, Jiang L, Nascimento A, LaBelle J, Haase R, Rozowsky J, Neyazi S, Baumgartner AC, Castellani S, Hoffman SE, Cameron A, Morrow M, Nguyen QD, Pericoli G, Madlener S, Mayr L, Dorfer C, Geyeregger R, Rota C, Ricken G, Ligon KL, Alexandrescu S, Cartaxo RT, Lau B, Uphadhyaya S, Koschmann C, Braun E, Danan-Gotthold M, Hu L, Siletti K, Sundstrom E, Hodge R, Lein E, Agnihotri S, Eisenstat DD, Stapleton S, King A, Bleil C, Mastronuzzi A, Cole KA, Waanders AJ, Montero Carcaboso A, Schuller U, Hargrave D, Vinci M, Carceller F, Haberler C, Slavc I, Linnarsson S, Gojo J, Monje M, Jones C, Filbin MG. Cancer Cell. 2024 Aug 27:S1535-6108(24)00305-2. doi: 10.1016/j.ccell.2024.08.006. PubMed |
| Circular RNA HMGCS1 sponges MIR4521 to aggravate type 2 diabetes-induced vascular endothelial dysfunction. Zhang M, Du G, Xie L, Xu Y, Chen W. Elife. 2024 Sep 5;13:RP97267. doi: 10.7554/eLife.97267. PubMed |
| Combinatorial targeting of glutamine metabolism and lysosomal-based lipid metabolism effectively suppresses glioblastoma. Zhong Y, Geng F, Mazik L, Yin X, Becker AP, Mohammed S, Su H, Xing E, Kou Y, Chiang CY, Fan Y, Guo Y, Wang Q, Li PK, Mo X, Lefai E, He L, Cheng X, Zhang X, Chakravarti A, Guo D. Cell Rep Med. 2024 Sep 17;5(9):101706. doi: 10.1016/j.xcrm.2024.101706. Epub 2024 Sep 4. PubMed |
| Inhibitory co-receptor Lag3 supports Foxp3(+) regulatory T cell function by restraining Myc-dependent metabolic programming. Kim D, Kim G, Yu R, Lee J, Kim S, Gleason MR, Qiu K, Montauti E, Wang LL, Fang D, Choi J, Chandel NS, Weinberg S, Min B. Immunity. 2024 Nov 12;57(11):2634-2650.e5. doi: 10.1016/j.immuni.2024.08.008. Epub 2024 Sep 4. PubMed |
| Acyl-coenzyme a binding protein (ACBP) - a risk factor for cancer diagnosis and an inhibitor of immunosurveillance. Montegut L, Liu P, Zhao L, Perez-Lanzon M, Chen H, Mao M, Zhang S, Derosa L, Naour JL, Lambertucci F, Mingoia S, Nogueira-Recalde U, Mena-Osuna R, Herranz-Montoya I, Djouder N, Baulande S, Pan H, Joseph A, Messaoudene M, Routy B, Fidelle M, Ben Ahmed T, Caron O, Busson P, Boulate D, Deschasaux-Tanguy M, Arnault N, Pol JG, Piaggio E, Touvier M, Zitvogel L, Delaloge S, Martins I, Kroemer G. Mol Cancer. 2024 Sep 6;23(1):187. doi: 10.1186/s12943-024-02098-5. PubMed |
| Human Smc5/6 recognises transcription-generated positive DNA supercoils. Diman A, Panis G, Castrogiovanni C, Prados J, Baechler B, Strubin M. Nat Commun. 2024 Sep 6;15(1):7805. doi: 10.1038/s41467-024-50646-w. PubMed |
Small-molecule GSDMD agonism in tumors stimulates antitumor immunity without toxicity.
Fontana P, Du G, Zhang Y, Zhang H, Vora SM, Hu JJ, Shi M, Tufan AB, Healy LB, Xia S, Lee DJ, Li Z, Baldominos P, Ru H, Luo HR, Agudo J, Lieberman J, Wu H.
Cell. 2024 Sep 2:S0092-8674(24)00898-5. doi: 10.1016/j.cell.2024.08.007.
PubMed
Associated Plasmids |
| The SW480 cell line as a model of resident and migrating colon cancer stem cells. Verhagen MP, Xu T, Stabile R, Joosten R, Tucci FA, van Royen M, Trerotola M, Alberti S, Sacchetti A, Fodde R. iScience. 2024 Aug 5;27(9):110658. doi: 10.1016/j.isci.2024.110658. eCollection 2024 Sep 20. PubMed |
| USP26 as a hepatitis B virus-induced deubiquitinase primes hepatocellular carcinogenesis by epigenetic remodeling. Ma M, Yi L, Pei Y, Zhang Q, Tong C, Zhao M, Chen Y, Zhu J, Zhang W, Yao F, Yang P, Zhang P. Nat Commun. 2024 Sep 9;15(1):7856. doi: 10.1038/s41467-024-52201-z. PubMed |
| Spatial single-cell isotope tracing reveals heterogeneity of de novo fatty acid synthesis in cancer. Buglakova E, Ekelof M, Schwaiger-Haber M, Schlicker L, Molenaar MR, Shahraz M, Stuart L, Eisenbarth A, Hilsenstein V, Patti GJ, Schulze A, Snaebjornsson MT, Alexandrov T. Nat Metab. 2024 Sep;6(9):1695-1711. doi: 10.1038/s42255-024-01118-4. Epub 2024 Sep 9. PubMed |
| New ZNHIT3 Variants Disrupting snoRNP Assembly Cause Prenatal PEHO Syndrome with Isolated Hydrops. Rahman ML, Bonnard AA, Wang F, Ruaud L, Guimiot F, Li Y, Defer I, Wang Y, Marchand V, Motorin Y, Yao B, Drunat S, Ghalei H. medRxiv [Preprint]. 2024 Aug 26:2024.08.26.24312490. doi: 10.1101/2024.08.26.24312490. PubMed |
Genetically encoded fluorescent reporter for polyamines.
Sharma P, Kim CY, Keys HR, Imada S, Joseph AB, Ferro L, Kunchok T, Anderson R, Yilmaz O, Weng JK, Jain A.
bioRxiv [Preprint]. 2024 Nov 17:2024.08.24.609500. doi: 10.1101/2024.08.24.609500.
PubMed
Associated Plasmids |
| SLC35A2 modulates paramyxovirus fusion events during infection. Yang Y, Wang Y, Campbell DE, Lee HW, Wang L, Baldridge M, Lopez CB. bioRxiv [Preprint]. 2024 Aug 27:2024.08.27.609835. doi: 10.1101/2024.08.27.609835. PubMed |
| Mitochondrial reprogramming by activating OXPHOS via glutamine metabolism in African American patients with bladder cancer. Kami Reddy KR, Piyarathna DWB, Park JH, Putluri V, Amara CS, Kamal AHM, Xu J, Kraushaar D, Huang S, Jung SY, Eberlin LS, Johnson JR, Kittles RA, Ballester LY, Parsawar K, Siddiqui MM, Gao J, Langer Gramer A, Bollag RJ, Terris MK, Lotan Y, Creighton CJ, Lerner SP, Sreekumar A, Kaipparettu BA, Putluri N. JCI Insight. 2024 Sep 10;9(17):e172336. doi: 10.1172/jci.insight.172336. PubMed |
| DBT is a metabolic switch for maintenance of proteostasis under proteasomal impairment. Hwang RD, Lu Y, Tang Q, Periz G, Park G, Li X, Xiang Q, Liu Y, Zhang T, Wang J. Elife. 2024 Sep 10;12:RP91002. doi: 10.7554/eLife.91002. PubMed |
| Non-redundant roles for the human mRNA decapping cofactor paralogs DCP1a and DCP1b. Vukovic I, Barnada SM, Ruffin JW, Karlin J, Lokareddy RK, Cingolani G, McMahon SB. Life Sci Alliance. 2024 Sep 10;7(11):e202402938. doi: 10.26508/lsa.202402938. Print 2024 Nov. PubMed |
| HDAC/H3K27ac-mediated transcription of NDUFA3 exerts protective effects on high glucose-treated human nucleus pulposus cells through improving mitochondrial function. Zheng C, Guo D, Zhang T, Hu W, Zhang B, Feng H, Gao Y, Yang G. Sci Rep. 2024 Sep 10;14(1):21165. doi: 10.1038/s41598-024-71810-8. PubMed |
| Terminal alpha1,2-fucosylation of glycosphingolipids by FUT1 is a key regulator in early cell-fate decisions. Chen S, Hayoun-Neeman D, Nagar M, Pinyan S, Hadad L, Yaacobov L, Alon L, Shachar LE, Swissa T, Kryukov O, Gershoni-Yahalom O, Rosental B, Cohen S, Lichtenstein RG. EMBO Rep. 2024 Oct;25(10):4433-4464. doi: 10.1038/s44319-024-00243-1. Epub 2024 Sep 10. PubMed |
| Development of ketobenzothiazole-based peptidomimetic TMPRSS13 inhibitors with low nanomolar potency. Joushomme A, Desilets A, Champagne W, Hassanzadeh M, Lemieux G, Gravel-Trudeau A, Lepage M, Lafreniere S, Froehlich U, List K, Boudreault PL, Leduc R. bioRxiv [Preprint]. 2024 Aug 29:2024.08.28.609965. doi: 10.1101/2024.08.28.609965. PubMed |
| Structural and systems characterization of phosphorylation on metabolic enzymes identifies sex-specific metabolic reprogramming in obesity. Tamir TY, Chaudhary S, Li AX, Trojan SE, Flower CT, Vo P, Cui Y, Davis JC, Mukkamala RS, Venditti FN, Hillis AL, Toker A, Vander Heiden MG, Spinelli JB, Kennedy NJ, Davis RJ, White FM. bioRxiv [Preprint]. 2024 Aug 29:2024.08.28.609894. doi: 10.1101/2024.08.28.609894. PubMed |
| RAPIDASH: Tag-free enrichment of ribosome-associated proteins reveals composition dynamics in embryonic tissue, cancer cells, and macrophages. Susanto TT, Hung V, Levine AG, Chen Y, Kerr CH, Yoo Y, Oses-Prieto JA, Fromm L, Zhang Z, Lantz TC, Fujii K, Wernig M, Burlingame AL, Ruggero D, Barna M. Mol Cell. 2024 Sep 19;84(18):3545-3563.e25. doi: 10.1016/j.molcel.2024.08.023. Epub 2024 Sep 10. PubMed |
| CCDC113 promotes colorectal cancer tumorigenesis and metastasis via TGF-beta signaling pathway. Hou C, Yang Y, Wang P, Xie H, Jin S, Zhao L, Wu G, Xing H, Chen H, Liu B, Du C, Sun X, He L. Cell Death Dis. 2024 Sep 11;15(9):666. doi: 10.1038/s41419-024-07036-3. PubMed |
| Organization of a functional glycolytic metabolon on mitochondria for metabolic efficiency. Wang H, Vant JW, Zhang A, Sanchez RG, Wu Y, Micou ML, Luczak V, Whiddon Z, Carlson NM, Yu SB, Jabbo M, Yoon S, Abushawish AA, Ghassemian M, Masubuchi T, Gan Q, Watanabe S, Griffis ER, Hammarlund M, Singharoy A, Pekkurnaz G. Nat Metab. 2024 Sep;6(9):1712-1735. doi: 10.1038/s42255-024-01121-9. Epub 2024 Sep 11. PubMed |
| Divergent iron regulatory states contribute to heterogeneity in breast cancer aggressiveness. Leineweber WD, Rowell MZ, Ranamukhaarachchi SK, Walker A, Li Y, Villazon J, Mestre-Farrera A, Hu Z, Yang J, Shi L, Fraley SI. iScience. 2024 Aug 3;27(9):110661. doi: 10.1016/j.isci.2024.110661. eCollection 2024 Sep 20. PubMed |
| Glaesserella parasuis serotype 4 exploits fibronectin via RlpA for tracheal colonization following porcine circovirus type 2 infection. Guo M, Li Y, Tang J, Wang Q, Wang Q, Zhou H, Lin H, Ma Z, Fan H. PLoS Pathog. 2024 Sep 12;20(9):e1012513. doi: 10.1371/journal.ppat.1012513. eCollection 2024 Sep. PubMed |
| Engineered model of heart tissue repair for exploring fibrotic processes and therapeutic interventions. Yang P, Zhu L, Wang S, Gong J, Selvaraj JN, Ye L, Chen H, Zhang Y, Wang G, Song W, Li Z, Cai L, Zhang H, Zhang D. Nat Commun. 2024 Sep 12;15(1):7996. doi: 10.1038/s41467-024-52221-9. PubMed |
| A metabolic crosstalk between liposarcoma and muscle sustains tumor growth. Manteaux G, Amsel A, Riquier-Morcant B, Prieto Romero J, Gayte L, Fourneaux B, Larroque M, Gruel N, Quignot C, Perot G, Jacq S, Cisse MY, Pomies P, Sengenes C, Chibon F, Heuillet M, Bellvert F, Watson S, Carrere S, Firmin N, Riscal R, Linares LK. Nat Commun. 2024 Sep 12;15(1):7940. doi: 10.1038/s41467-024-51827-3. PubMed |
| Transiently formed nucleus-to-cilium microtubule arrays mediate senescence initiation in a KIFC3-dependent manner. Robichaud JH, Zhang Y, Chen C, He K, Huang Y, Zhang X, Sun X, Ma X, Hardiman G, Morrison CG, Dong Z, LeBrasseur NK, Ling K, Hu J. Nat Commun. 2024 Sep 12;15(1):7977. doi: 10.1038/s41467-024-52363-w. PubMed |
| SIRT1-mediated deacetylation of FOXO3 enhances mitophagy and drives hormone resistance in endometrial cancer. Wei X, Xiong X, Wang P, Zhang S, Peng D. Mol Med. 2024 Sep 12;30(1):147. doi: 10.1186/s10020-024-00915-7. PubMed |
| c-Myc alone is enough to reprogram fibroblasts into functional macrophages. Li S, Chen G, Huang X, Zhang Y, Shen S, Feng H, Li Y. J Hematol Oncol. 2024 Sep 12;17(1):83. doi: 10.1186/s13045-024-01605-x. PubMed |
| Bisecting GlcNAc modification reverses the chemoresistance via attenuating the function of P-gp. Tan Z, Ning L, Cao L, Zhou Y, Li J, Yang Y, Lin S, Ren X, Xue X, Kang H, Li X, Guan F. Theranostics. 2024 Aug 19;14(13):5184-5199. doi: 10.7150/thno.93879. eCollection 2024. PubMed |
| MEK Inhibitors Lead to PDGFR Pathway Upregulation and Sensitize Tumors to RAF Dimer Inhibitors in NF1-Deficient Malignant Peripheral Nerve Sheath Tumor. Miranda-Roman MA, Lee CJ, Fishinevich E, Ran L, Patel AJ, Yan J, Khudoynazarova MN, Warda S, Pachai MR, Chen Y, Chi P. Clin Cancer Res. 2024 Nov 15;30(22):5154-5165. doi: 10.1158/1078-0432.CCR-24-1750. PubMed |
| RUNX1 interacts with lncRNA SMANTIS to regulate monocytic cell functions. Weiss LM, Warwick T, Zehr S, Gunther S, Wolf S, Schmachtel T, Izquierdo Ponce J, Palfi K, Teichmann T, Schneider A, Stotzel J, Knapp S, Weigert A, Savai R, Rieger MA, Oellerich T, Wittig I, Oo JA, Brandes RP, Leisegang MS. Commun Biol. 2024 Sep 13;7(1):1131. doi: 10.1038/s42003-024-06794-2. PubMed |
| In vivo CAR T cell therapy against angioimmunoblastic T cell lymphoma. Krug A, Saidane A, Martinello C, Fusil F, Michels A, Buchholz CJ, Ricci JE, Verhoeyen E. J Exp Clin Cancer Res. 2024 Sep 14;43(1):262. doi: 10.1186/s13046-024-03179-5. PubMed |
| PDCD10 Is a Key Player in TMZ-Resistance and Tumor Cell Regrowth: Insights into Its Underlying Mechanism in Glioblastoma Cells. Zhu Y, Kim SN, Chen ZR, Will R, Zhong RD, Dammann P, Sure U. Cells. 2024 Aug 28;13(17):1442. doi: 10.3390/cells13171442. PubMed |
| The Inhibiting Effect of GB-2, (+)-Catechin, Theaflavin, and Theaflavin 3-Gallate on Interaction between ACE2 and SARS-CoV-2 EG.5.1 and HV.1 Variants. Lu CK, Lung J, Shu LH, Liu HT, Wu YH, Lin YS, Yang YH, Wu YH, Wu CY. Int J Mol Sci. 2024 Aug 31;25(17):9498. doi: 10.3390/ijms25179498. PubMed |
| Dynamic phosphorylation of FOXA1 by Aurora B guides post-mitotic gene reactivation. Zhang T, Liu S, Durojaye O, Xiong F, Fang Z, Ullah T, Fu C, Sun B, Jiang H, Xia P, Wang Z, Yao X, Liu X. Cell Rep. 2024 Sep 24;43(9):114739. doi: 10.1016/j.celrep.2024.114739. Epub 2024 Sep 13. PubMed |
| Modeling antisense oligonucleotide therapy in MECP2 duplication syndrome human iPSC-derived neurons reveals gene expression programs responsive to MeCP2 levels. Bajikar SS, Sztainberg Y, Trostle AJ, Tirumala HP, Wan YW, Harrop CL, Bengtsson JD, Carvalho CMB, Pehlivan D, Suter B, Neul JL, Liu Z, Jafar-Nejad P, Rigo F, Zoghbi HY. Hum Mol Genet. 2024 Nov 8;33(22):1986-2001. doi: 10.1093/hmg/ddae135. PubMed |
| Protein UFMylation regulates early events during ribosomal DNA-damage response. Panichnantakul P, Aguilar LC, Daynard E, Guest M, Peters C, Vogel J, Oeffinger M. Cell Rep. 2024 Sep 24;43(9):114738. doi: 10.1016/j.celrep.2024.114738. Epub 2024 Sep 14. PubMed |
| ATM phosphorylation of CD98HC increases antiporter membrane localization and prevents chronic toxic glutamate accumulation in Ataxia telangiectasia. Bishop A, Romero JC, Tonapi S, Parihar M, Loranc E, Miller H, Lawrence L, Bassani N, Robledo D, Cao L, Nie J, Kanda K, Stoja A, Garcia N, Gorthi A, Stoveken B, Lane A, Fan T, Cassel T, Zha S, Musi N. Res Sq [Preprint]. 2024 Sep 5:rs.3.rs-4947457. doi: 10.21203/rs.3.rs-4947457/v1. PubMed |
| Persistent tailoring of MSC activation through genetic priming. Beauregard MA, Bedford GC, Brenner DA, Sanchez Solis LD, Nishiguchi T, Abhimanyu, Longlax SC, Mahata B, Veiseh O, Wenzel PL, DiNardo AR, Hilton IB, Diehl MR. Mol Ther Methods Clin Dev. 2024 Aug 8;32(3):101316. doi: 10.1016/j.omtm.2024.101316. eCollection 2024 Sep 12. PubMed |
| Claudin-4 remodeling of nucleus-cell cycle crosstalk maintains ovarian tumor genome stability and drives resistance to genomic instability-inducing agents. Villagomez FR, Lang J, Nunez-Avellaneda D, Behbakht K, Dimmick HL, Webb P, Nephew KP, Neville M, Woodruff ER, Bitler BG. bioRxiv [Preprint]. 2024 Sep 7:2024.09.04.611120. doi: 10.1101/2024.09.04.611120. PubMed |
| USP37 prevents premature disassembly of stressed replisomes by TRAIP. Kochenova OV, D'Alessandro G, Pilger D, Schmid E, Richards SL, Garcia MR, Jhujh SS, Voigt A, Gupta V, Carnie CJ, Wu RA, Gueorguieva N, Stewart GS, Walter JC, Jackson SP. bioRxiv [Preprint]. 2024 Sep 4:2024.09.03.611025. doi: 10.1101/2024.09.03.611025. PubMed |
| Cis-Regulatory Element and Transcription Factor Circuitry Required for Cell-Type Specific Expression of FOXP3. Umhoefer JM, Arce MM, Whalen S, Dajani R, Goudy L, Kasinathan S, Belk JA, Zhang W, Zhou R, Subramanya S, Hernandez R, Tran C, Kirthivasan N, Freimer JW, Mowery CT, Nguyen V, Ota M, Gowen BG, Simeonov DR, Curie GL, Li Z, Corn JE, Chang HY, Gilbert LA, Satpathy AT, Pollard KS, Marson A. bioRxiv [Preprint]. 2025 Jan 14:2024.08.30.610436. doi: 10.1101/2024.08.30.610436. PubMed |
| Contribution of A1 to macrophage survival in cooperation with MCL-1 and BCL-X(L) in a murine cell model of myeloid differentiation. Vier J, Hacker G, Kirschnek S. Cell Death Dis. 2024 Sep 16;15(9):677. doi: 10.1038/s41419-024-07064-z. PubMed |
| A feedback loop between plakophilin 4 and YAP signaling regulates keratinocyte differentiation. Muller L, Gutschner T, Hatzfeld M. iScience. 2024 Aug 19;27(9):110762. doi: 10.1016/j.isci.2024.110762. eCollection 2024 Sep 20. PubMed |
| ADAMTS12 promotes fibrosis by restructuring extracellular matrix to enable activation of injury-responsive fibroblasts. Hoeft K, Koch L, Ziegler S, Zhang L, Luetke S, Tanzer MC, Mohanta D, Schumacher D, Schreibing F, Long Q, Kim H, Klinkhammer BM, Schikarski C, Maryam S, Baens M, Hermann J, Krieg S, Peisker F, De Laporte L, Schaefer GJ, Menzel S, Jankowski J, Humphreys BD, Wahida A, Schneider RK, Versele M, Boor P, Mann M, Sengle G, Hayat S, Kramann R. J Clin Invest. 2024 Sep 17;134(18):e170246. doi: 10.1172/JCI170246. PubMed |
| CRISPR/Cas13d targeting suppresses repeat-associated non-AUG translation of C9orf72 hexanucleotide repeat RNA. Liu H, Zhao XF, Lu YN, Hayes LR, Wang J. J Clin Invest. 2024 Sep 17;134(21):e179016. doi: 10.1172/JCI179016. PubMed |
| Development of an antigen-based approach to noninvasively image CAR T cells in real time and as a predictive tool. Frose J, Rowley J, Farid AS, Rakhshandehroo T, Leclerc P, Mak H, Allen H, Moravej H, Munaretto L, Millan-Barea L, Codet E, Glockner H, Jacobson C, Hemann M, Rashidian M. Sci Adv. 2024 Sep 20;10(38):eadn3816. doi: 10.1126/sciadv.adn3816. Epub 2024 Sep 18. PubMed |
| Epstein-Barr virus induces host shutoff extensively via BGLF5-independent mechanisms. Casco A, Ohashi M, Johannsen E. Cell Rep. 2024 Oct 22;43(10):114743. doi: 10.1016/j.celrep.2024.114743. Epub 2024 Sep 18. PubMed |
| Identification of genes supporting cold resistance of mammalian cells: lessons from a hibernator. Sone M, Mitsuhashi N, Sugiura Y, Matsuoka Y, Maeda R, Yamauchi A, Okahashi R, Yamashita J, Sone K, Enju S, Anegawa D, Yamaguchi Y. Cell Death Dis. 2024 Sep 19;15(9):685. doi: 10.1038/s41419-024-07059-w. PubMed |
| MFSD7C protects hemolysis-induced lung impairments by inhibiting ferroptosis. Wang H, You X, Wang J, Chen X, Gao Y, Wang M, Zhang W, Zhang J, Yu Y, Han B, Qi M, Liu X, Lou H, Dong T. Nat Commun. 2024 Sep 19;15(1):8226. doi: 10.1038/s41467-024-52537-6. PubMed |
| ARID1A overexpression inhibits colorectal cancer cell migration through the regulation of epithelial‑mesenchymal transition. Wanna-Udom S, Aluksanasuwan S, Somsuan K, Mongkolwat W, Sakulsak N. Mol Med Rep. 2024 Nov;30(5):201. doi: 10.3892/mmr.2024.13325. Epub 2024 Sep 20. PubMed |
| Dynamic chromatin architecture identifies new autoimmune-associated enhancers for IL2 and novel genes regulating CD4+ T cell activation. Pahl MC, Sharma P, Thomas RM, Thompson Z, Mount Z, Pippin JA, Morawski PA, Sun P, Su C, Campbell D, Grant SFA, Wells AD. Elife. 2024 Sep 20;13:RP96852. doi: 10.7554/eLife.96852. PubMed |
| CircHIPK3 regulates cementoblast differentiation via the miR-10b-5p/DOHH/NF-kappaB axis. Zhang G, Tao Z, Li B, Zhu J, Mo L, Cao Z, Du M, He H. Cell Signal. 2024 Dec;124:111427. doi: 10.1016/j.cellsig.2024.111427. Epub 2024 Sep 18. PubMed |
| Identification of Cables1 as a critical host factor that promotes ALV-J replication via genome-wide CRISPR/Cas9 gene knockout screening. Liu P, Jiang J, Chen Y, Gao F, Wang S, Yu M, Liu Y, Guo R, Zhang L, Xu Z, Wang C, Qi X, Zhang Y, Cui H, Duan Y, Wu S, Gao Y. J Biol Chem. 2024 Nov;300(11):107804. doi: 10.1016/j.jbc.2024.107804. Epub 2024 Sep 21. PubMed |
| METTL18 functions as a Phenotypic Regulator in Src-Dependent Oncogenic Responses of HER2-Negative Breast Cancer. Kim HG, Kim JH, Kim KH, Yoo BC, Kang SU, Kim YB, Kim S, Paik HJ, Lee JE, Nam SJ, Parameswaran N, Han JW, Manavalan B, Cho JY. Int J Biol Sci. 2024 Sep 3;20(12):4731-4749. doi: 10.7150/ijbs.96487. eCollection 2024. PubMed |
| SARS-CoV-2 ORF10 hijacking ubiquitination machinery reveals potential unique drug targeting sites. Zhu K, Song L, Wang L, Hua L, Luo Z, Wang T, Qin B, Yuan S, Gao X, Mi W, Cui S. Acta Pharm Sin B. 2024 Sep;14(9):4164-4173. doi: 10.1016/j.apsb.2024.05.018. Epub 2024 May 22. PubMed |
| EspH utilizes phosphoinositide and Rab binding domains to interact with plasma membrane infection sites and Rab GTPases. Nandi I, Ramachandran RP, Shalev DE, Schneidman-Duhovny D, Shtuhin-Rahav R, Melamed-Book N, Zlotkin-Rivkin E, Rouvinski A, Rosenshine I, Aroeti B. Gut Microbes. 2024 Jan-Dec;16(1):2400575. doi: 10.1080/19490976.2024.2400575. Epub 2024 Sep 23. PubMed |
| SIRT6 loss causes intervertebral disc degeneration in mice by promoting senescence and SASP status. Ramteke P, Watson B, Toci M, Tran VA, Johnston S, Tsingas M, Barve RA, Mitra R, Loeser RF, Collins JA, Risbud MV. bioRxiv [Preprint]. 2024 Sep 9:2024.09.09.612072. doi: 10.1101/2024.09.09.612072. PubMed |
| PIP5K-Ras bistability initiates plasma membrane symmetry breaking to regulate cell polarity and migration. Deng Y, Banerjee T, Pal DS, Banerjee P, Zhan H, Borleis J, Igleias PA, Devreotes PN. bioRxiv [Preprint]. 2024 Sep 15:2024.09.15.613115. doi: 10.1101/2024.09.15.613115. PubMed |
| A sustained calcium response mediated by IP3 receptor anchoring to the desmosome is essential for apoptotic cell elimination. Cho Y, Koyama-Honda I, Tanimura A, Matsuzawa K, Ikenouchi J. Curr Biol. 2024 Oct 21;34(20):4835-4844.e4. doi: 10.1016/j.cub.2024.08.057. Epub 2024 Sep 23. PubMed |
| Death-associated protein kinase 3 modulates migration and invasion of triple-negative breast cancer cells. Wang J, Tran-Huynh AM, Kim BJ, Chan DW, Holt MV, Fandino D, Yu X, Qi X, Wang J, Zhang W, Wu YH, Anurag M, Zhang XHF, Zhang B, Cheng C, Foulds CE, Ellis MJ. PNAS Nexus. 2024 Sep 12;3(9):pgae401. doi: 10.1093/pnasnexus/pgae401. eCollection 2024 Sep. PubMed |
| Hydrogen sulfide-mediated persulfidation regulates homocysteine metabolism and enhances ferroptosis in non-small cell lung cancer. Zheng H, Chen H, Cai Y, Shen M, Li X, Han Y, Deng X, Cao H, Liu J, Li H, Liu B, Li G, Wang X, Chen H, Hou J, Lin SH, Zong L, Zhang Y. Mol Cell. 2024 Oct 17;84(20):4016-4030.e6. doi: 10.1016/j.molcel.2024.08.035. Epub 2024 Sep 24. PubMed |
| Interleukin-34-orchestrated tumor-associated macrophage reprogramming is required for tumor immune escape driven by p53 inactivation. Nian Z, Dou Y, Shen Y, Liu J, Du X, Jiang Y, Zhou Y, Fu B, Sun R, Zheng X, Tian Z, Wei H. Immunity. 2024 Oct 8;57(10):2344-2361.e7. doi: 10.1016/j.immuni.2024.08.015. Epub 2024 Sep 24. PubMed |
| Mutational scanning of CRX classifies clinical variants and reveals biochemical properties of the transcriptional effector domain. Shepherdson JL, Granas DM, Li J, Shariff Z, Plassmeyer SP, Holehouse AS, White MA, Cohen BA. Genome Res. 2024 Oct 29;34(10):1540-1552. doi: 10.1101/gr.279415.124. PubMed |
| Saturation mutagenesis-reinforced functional assays for disease-related genes. Ma K, Huang S, Ng KK, Lake NJ, Joseph S, Xu J, Lek A, Ge L, Woodman KG, Koczwara KE, Cohen J, Ho V, O'Connor CL, Brindley MA, Campbell KP, Lek M. Cell. 2024 Nov 14;187(23):6707-6724.e22. doi: 10.1016/j.cell.2024.08.047. Epub 2024 Sep 25. PubMed |
| Droplet-based functional CRISPR screening of cell-cell interactions by SPEAC-seq. Faust Akl C, Linnerbauer M, Li Z, Lee HG, Clark IC, Wheeler MA, Quintana FJ. Nat Protoc. 2025 Feb;20(2):440-461. doi: 10.1038/s41596-024-01056-1. Epub 2024 Sep 26. PubMed |
| SIK2 Controls the Homeostatic Character of the POMC Secretome Acutely in Response to Pharmacological ER Stress Induction. Turkuner MS, Yazici A, Ozcan F. Cells. 2024 Sep 17;13(18):1565. doi: 10.3390/cells13181565. PubMed |
| mTOR/miR-142-3p/PRAS40 signaling cascade is critical for tuberous sclerosis complex-associated renal cystogenesis. Zhao S, Hao S, Zhou J, Chen X, Zhang T, Qi Z, Zhang T, Jalal S, Zhai C, Yin L, Bo Y, Teng H, Wang Y, Gao D, Zhang H, Huang L. Cell Mol Biol Lett. 2024 Sep 27;29(1):125. doi: 10.1186/s11658-024-00638-x. PubMed |
| NoxO1 Determines the Level of ROS Formation by the Nox1-Centered NADPH Oxidase. Hebchen DM, Spaeth M, Muller N, Schroder K. Antioxidants (Basel). 2024 Sep 14;13(9):1113. doi: 10.3390/antiox13091113. PubMed |
| Gallium Uncouples Iron Metabolism to Enhance Glioblastoma Radiosensitivity. Owusu SB, Zaher A, Ahenkorah S, Pandya DN, Wadas TJ, Petronek MS. Int J Mol Sci. 2024 Sep 18;25(18):10047. doi: 10.3390/ijms251810047. PubMed |
| The Autophagy Receptor SQSTM1/p62 Is a Restriction Factor of HCMV Infection. Kramer N, Mato UG, Krauter S, Buscher N, Afifi A, Herhaus L, Florin L, Plachter B, Zimmermann C. Viruses. 2024 Sep 10;16(9):1440. doi: 10.3390/v16091440. PubMed |
| Clustered macrophages cooperate to eliminate tumors via coordinated intrudopodia. Dooling LJ, Anlas AA, Tobin MP, Ontko NM, Marchena T, Wang M, Andrechak JC, Discher DE. bioRxiv [Preprint]. 2024 Sep 20:2024.09.19.613918. doi: 10.1101/2024.09.19.613918. PubMed |
| Hypoxia-induced TGFBI maintains glioma stem cells by stabilizing EphA2. Chen Z, Wang J, Peng P, Liu G, Dong M, Zhang X, Zhang Y, Yang X, Wan L, Xiang W, Zhang S, Zhang B, Wu Q, Yu X, Wan F. Theranostics. 2024 Sep 9;14(15):5778-5792. doi: 10.7150/thno.95141. eCollection 2024. PubMed |
| The Y498T499-SARS-CoV-2 spike (S) protein interacts poorly with rat ACE2 and does not affect the rat lung. Green AL, De Bellis D, Cowell E, Lenchine RV, Penn T, Kris LP, McEvoy-May J, Bihari S, Dixon DL, Carr JM. Access Microbiol. 2024 Sep 27;6(9):000839.v3. doi: 10.1099/acmi.0.000839.v3. eCollection 2024. PubMed |
| Corrigendum to "A retrospective study on the clinical and molecular outcomes of calpainopathy in a Turkish patient cohort": [Turkish Journal of Medical Sciences 54 (1) 2024 86-98]. Sahin IO, Karatas E, Demir M, Tan B, Per H, Ozkul Y, Dundar M. Turk J Med Sci. 2024 Sep 30;54(4):880. doi: 10.55730/1300-0144.5861. eCollection 2024. PubMed |
| CRISPR-Cas9 screens reveal regulators of ageing in neural stem cells. Ruetz TJ, Pogson AN, Kashiwagi CM, Gagnon SD, Morton B, Sun ED, Na J, Yeo RW, Leeman DS, Morgens DW, Tsui CK, Li A, Bassik MC, Brunet A. Nature. 2024 Oct;634(8036):1150-1159. doi: 10.1038/s41586-024-07972-2. Epub 2024 Oct 2. PubMed |
| High specificity of engineered T cells with third generation CAR (CD28-4-1BB-CD3-zeta) based on biotin-bound monomeric streptavidin for potential tumor immunotherapy. Gallego-Valle J, Perez-Fernandez VA, Rosales-Magallares J, Gil-Manso S, Castella M, Gonzalez-Navarro EA, Correa-Rocha R, Juan M, Pion M. Front Immunol. 2024 Sep 19;15:1448752. doi: 10.3389/fimmu.2024.1448752. eCollection 2024. PubMed |
| De novo GTP synthesis is a metabolic vulnerability for the interception of brain metastases. Kieliszek AM, Mobilio D, Bassey-Archibong BI, Johnson JW, Piotrowski ML, de Araujo ED, Sedighi A, Aghaei N, Escudero L, Ang P, Gwynne WD, Zhang C, Quaile A, McKenna D, Subapanditha M, Tokar T, Vaseem Shaikh M, Zhai K, Chafe SC, Gunning PT, Montenegro-Burke JR, Venugopal C, Magolan J, Singh SK. Cell Rep Med. 2024 Oct 15;5(10):101755. doi: 10.1016/j.xcrm.2024.101755. Epub 2024 Oct 4. PubMed |
| Gene therapy for diffuse pleural mesotheliomas in preclinical models by concurrent expression of NF2 and SuperHippo. Zhu R, Liu X, Zhang X, Zhong Z, Qi S, Jin R, Gu Y, Wang Y, Ling C, Chen K, Ye D, Yu FX. Cell Rep Med. 2024 Oct 15;5(10):101763. doi: 10.1016/j.xcrm.2024.101763. Epub 2024 Oct 4. PubMed |
| Modeling high-risk Wilms tumors enables the discovery of therapeutic vulnerability. Ma G, Gao A, Chen J, Liu P, Sarda R, Gulliver J, Wang Y, Joiner C, Hu M, Kim EJ, Yeger H, Le HD, Chen X, Li WJ, Xu W. Cell Rep Med. 2024 Oct 15;5(10):101770. doi: 10.1016/j.xcrm.2024.101770. Epub 2024 Oct 4. PubMed |
| The VLDLR entry receptor is required for the pathogenesis of multiple encephalitic alphaviruses. Palakurty S, Raju S, Sariol A, Chong Z, Wagoner N, Ma H, Zimmerman O, Adams LJ, Carmona C, Liu Z, Fremont DH, Whelan SPJ, Klimstra WB, Diamond MS. Cell Rep. 2024 Oct 22;43(10):114809. doi: 10.1016/j.celrep.2024.114809. Epub 2024 Oct 5. PubMed |
| Enhancer reprogramming underlies therapeutic utility of a SMARCA2 degrader in SMARCA4 mutant cancer. Kotagiri S, Blazanin N, Xi Y, Han Y, Qudratullah M, Liang X, Wang Y, Pandey P, Mazhar H, Lam TN, Singh AK, Wang J, Lissanu Y. Cell Chem Biol. 2024 Dec 19;31(12):2069-2084.e9. doi: 10.1016/j.chembiol.2024.09.004. Epub 2024 Oct 7. PubMed |
| Targeting RSV-neutralizing B cell receptors with anti-idiotypic antibodies. Scharffenberger SC, Wan YH, Homad LJ, Kher G, Haynes AM, Poudel B, Sinha IR, Aldridge N, Pai A, Bibby M, Chhan CB, Davis AR, Moodie Z, Palacio MB, Escolano A, McElrath MJ, Boonyaratanakornkit J, Pancera M, McGuire AT. Cell Rep. 2024 Oct 22;43(10):114811. doi: 10.1016/j.celrep.2024.114811. Epub 2024 Oct 8. PubMed |
| ICP22-defined condensates mediate RNAPII deubiquitylation by UL36 and promote HSV-1 transcription. Qi H, Yin M, Xiong F, Ren X, Chen K, Qin HB, Wang E, Chen G, Yang L, Liu LD, Zhang H, Cao X, Fraser NW, Luo MH, Zeng WB, Zhou J. Cell Rep. 2024 Oct 22;43(10):114792. doi: 10.1016/j.celrep.2024.114792. Epub 2024 Oct 9. PubMed |
| Disruption of cellular plasticity by repeat RNAs in human pancreatic cancer. You E, Danaher P, Lu C, Sun S, Zou L, Phillips IE, Rojas AS, Ho NI, Song Y, Raabe MJ, Xu KH, Richieri PM, Li H, Aston N, Porter RL, Patel BK, Nieman LT, Schurman N, Hudson BM, North K, Church SE, Deshpande V, Liss AS, Kim TK, Cui Y, Kim Y, Greenbaum BD, Aryee MJ, Ting DT. Cell. 2024 Dec 12;187(25):7232-7247.e23. doi: 10.1016/j.cell.2024.09.024. Epub 2024 Oct 8. PubMed |
| Multi-omic human pancreatic islet endoplasmic reticulum and cytokine stress response mapping provides type 2 diabetes genetic insights. Sokolowski EK, Kursawe R, Selvam V, Bhuiyan RM, Thibodeau A, Zhao C, Spracklen CN, Ucar D, Stitzel ML. Cell Metab. 2024 Nov 5;36(11):2468-2488.e7. doi: 10.1016/j.cmet.2024.09.006. Epub 2024 Oct 8. PubMed |
| Endocrine persistence in ER+ breast cancer is accompanied by metabolic vulnerability in oxidative phosphorylation. Tau S, Chamberlin MD, Yang H, Marotti JD, Roberts AM, Carmichael MM, Cressey L, Dragnev C, Demidenko E, Hampsch RA, Soucy SM, Kolling F, Samkoe KS, Alvarez JV, Kettenbach AN, Miller TW. bioRxiv [Preprint]. 2024 Sep 27:2024.09.26.615177. doi: 10.1101/2024.09.26.615177. PubMed |
| Cytotoxicity of Activator Expression in CRISPR-based Transcriptional Activation Systems. Maddineni A, Liang Z, Jambardi S, Roy S, Tycko J, Patil A, Manzano M, Gottwein E. bioRxiv [Preprint]. 2024 Sep 23:2024.09.23.614524. doi: 10.1101/2024.09.23.614524. PubMed |
| TRIM33 promotes glycolysis through regulating P53 K48-linked ubiquitination to promote esophageal squamous cell carcinoma growth. Xia T, Meng L, Xu G, Sun H, Chen H. Cell Death Dis. 2024 Oct 10;15(10):740. doi: 10.1038/s41419-024-07137-z. PubMed |
| Mitochondrial MOF regulates energy metabolism in heart failure via ATP5B hyperacetylation. Hu Y, Zheng Y, Liu C, You Y, Wu Y, Wang P, Wu Y, Ba H, Lu J, Yuan Y, Liu P, Mao Y. Cell Rep. 2024 Oct 22;43(10):114839. doi: 10.1016/j.celrep.2024.114839. Epub 2024 Oct 10. PubMed |
| Single cell atlas reveals multilayered metabolic heterogeneity across tumour types. Zhou Z, Dong D, Yuan Y, Luo J, Liu XD, Chen LY, Wang G, Yin Y. EBioMedicine. 2024 Nov;109:105389. doi: 10.1016/j.ebiom.2024.105389. Epub 2024 Oct 10. PubMed |
| Long-term breast cancer response to CDK4/6 inhibition defined by TP53-mediated geroconversion. Kudo R, Safonov A, Jones C, Moiso E, Dry JR, Shao H, Nag S, da Silva EM, Yildirim SY, Li Q, O'Connell E, Patel P, Will M, Fushimi A, Benitez M, Bradic M, Fan L, Nakshatri H, Sudhan DR, Denz CR, Huerga Sanchez I, Reis-Filho JS, Goel S, Koff A, Weigelt B, Khan QJ, Razavi P, Chandarlapaty S. Cancer Cell. 2024 Nov 11;42(11):1919-1935.e9. doi: 10.1016/j.ccell.2024.09.009. Epub 2024 Oct 10. PubMed |
| The two major splice variants of scavenger receptor BI differ by their interactions with lipoproteins and cellular localization in endothelial cells. Potapenko A, Frey K, Schlumpf E, Robert J, Wollscheid B, von Eckardstein A, Rohrer L. J Lipid Res. 2024 Nov;65(11):100665. doi: 10.1016/j.jlr.2024.100665. Epub 2024 Oct 10. PubMed |
| SATB1 prevents immune cell infiltration by regulating chromatin organization and gene expression of a chemokine gene cluster in T cells. Wang B, Bian Q. Commun Biol. 2024 Oct 11;7(1):1304. doi: 10.1038/s42003-024-07021-8. PubMed |
| Ehbp1 orchestrates orderly sorting of Wnt/Wingless to the basolateral and apical cell membranes. Gao Y, Feng J, Zhang Y, Yi M, Zhang L, Yan Y, Zhu AJ, Liu M. EMBO Rep. 2024 Nov;25(11):5053-5079. doi: 10.1038/s44319-024-00289-1. Epub 2024 Oct 14. PubMed |
| Synaptic neoteny of human cortical neurons requires species-specific balancing of SRGAP2-SYNGAP1 cross-inhibition. Libe-Philippot B, Iwata R, Recupero AJ, Wierda K, Bernal Garcia S, Hammond L, van Benthem A, Limame R, Ditkowska M, Beckers S, Gaspariunaite V, Peze-Heidsieck E, Remans D, Charrier C, Theys T, Polleux F, Vanderhaeghen P. Neuron. 2024 Oct 9:S0896-6273(24)00645-7. doi: 10.1016/j.neuron.2024.08.021. PubMed |
| CRISPR screens unveil nutrient-dependent lysosomal and mitochondrial nodes impacting intestinal tissue-resident memory CD8(+) T cell formation. Raynor JL, Collins N, Shi H, Guy C, Saravia J, Ah Lim S, Chapman NM, Zhou P, Wang Y, Sun Y, Risch I, Hu H, Kc A, Sun R, Shrestha S, Huang H, Connelly JP, Pruett-Miller SM, Reina-Campos M, Goldrath AW, Belkaid Y, Chi H. Immunity. 2024 Nov 12;57(11):2597-2614.e13. doi: 10.1016/j.immuni.2024.09.013. Epub 2024 Oct 14. PubMed |
| Enhanced kinase translocation reporters for simultaneous real-time measurement of PKA, ERK, and Ca(2). Tsai SJ, Gong Y, Dabbs A, Zahra F, Xu J, Geske A, Caterina MJ, Gould SJ. bioRxiv [Preprint]. 2024 Oct 2:2024.09.30.615856. doi: 10.1101/2024.09.30.615856. PubMed |
| Lighting up arginine metabolism reveals its functional diversity in physiology and pathology. Li R, Li Y, Jiang K, Zhang L, Li T, Zhao A, Zhang Z, Xia Y, Ge K, Chen Y, Wang C, Tang W, Liu S, Lin X, Song Y, Mei J, Xiao C, Wang A, Zou Y, Li X, Chen X, Ju Z, Jia W, Loscalzo J, Sun Y, Fang W, Yang Y, Zhao Y. Cell Metab. 2025 Jan 7;37(1):291-304.e9. doi: 10.1016/j.cmet.2024.09.011. Epub 2024 Oct 15. PubMed |
| Redirecting the pioneering function of FOXA1 with covalent small molecules. Won SJ, Zhang Y, Reinhardt CJ, Hargis LM, MacRae NS, DeMeester KE, Njomen E, Remsberg JR, Melillo B, Cravatt BF, Erb MA. Mol Cell. 2024 Nov 7;84(21):4125-4141.e10. doi: 10.1016/j.molcel.2024.09.024. Epub 2024 Oct 15. PubMed |
| PD-L1 protects tumor-associated dendritic cells from ferroptosis during immunogenic chemotherapy. Xiao K, Zhang S, Peng Q, Du Y, Yao X, Ng II, Tang H. Cell Rep. 2024 Nov 26;43(11):114868. doi: 10.1016/j.celrep.2024.114868. Epub 2024 Oct 17. PubMed |
| Opposing regulation of the STING pathway in hepatic stellate cells by NBR1 and p62 determines the progression of hepatocellular carcinoma. Nishimura S, Linares JF, L'Hermitte A, Duran A, Cid-Diaz T, Martinez-Ordonez A, Ruiz-Martinez M, Kudo Y, Marzio A, Heikenwalder M, Roberts LR, Diaz-Meco MT, Moscat J. Mol Cell. 2024 Dec 5;84(23):4660-4676.e10. doi: 10.1016/j.molcel.2024.09.026. Epub 2024 Oct 17. PubMed |
| Glutamine sensing licenses cholesterol synthesis. Garcia BM, Melchinger P, Medeiros T, Hendrix S, Prabhu K, Corrado M, Kingma J, Gorbatenko A, Deshwal S, Veronese M, Scorrano L, Pearce E, Giavalisco P, Zelcer N, Pernas L. EMBO J. 2024 Dec;43(23):5837-5856. doi: 10.1038/s44318-024-00269-0. Epub 2024 Oct 21. PubMed |
| TRPC3-mediated NFATc1 calcium signaling promotes triple negative breast cancer migration through regulating glypican-6 and focal adhesion. Wang Y, Zhuang X, Qi Y, Yiu L, Li Z, Chan YW, Liu X, Tsang SY. Pflugers Arch. 2025 Feb;477(2):253-272. doi: 10.1007/s00424-024-03030-y. Epub 2024 Oct 22. PubMed |
| P-stalk ribosomes act as master regulators of cytokine-mediated processes. Dopler A, Alkan F, Malka Y, van der Kammen R, Hoefakker K, Taranto D, Kocabay N, Mimpen I, Ramirez C, Malzer E, Isaeva OI, Kerkhoff M, Gangaev A, Silva J, Ramalho S, Hoekman L, Altelaar M, Beijersbergen R, Akkari L, Yewdell JW, Kvistborg P, Faller WJ. Cell. 2024 Nov 27;187(24):6981-6993.e23. doi: 10.1016/j.cell.2024.09.039. Epub 2024 Oct 21. PubMed |
| Single-cell multi-modal integrative analyses highlight functional dynamic gene regulatory networks directing human cardiac development. Holman AR, Tran S, Destici E, Farah EN, Li T, Nelson AC, Engler AJ, Chi NC. Cell Genom. 2024 Nov 13;4(11):100680. doi: 10.1016/j.xgen.2024.100680. Epub 2024 Oct 21. PubMed |
| Protocol to identify E3 ligases amenable to biodegraders using a cell-based screening. Sorbara M, Cristol M, Cornebois A, Desrumeaux K, Cordelier P, Bery N. STAR Protoc. 2024 Dec 20;5(4):103413. doi: 10.1016/j.xpro.2024.103413. Epub 2024 Oct 24. PubMed |
| Deciphering the Landscape of GATA-Mediated Transcriptional Regulation in Gastric Cancer. Begolli R, Patouna A, Vardakas P, Xagara A, Apostolou K, Kouretas D, Giakountis A. Antioxidants (Basel). 2024 Oct 18;13(10):1267. doi: 10.3390/antiox13101267. PubMed |
| Wnt specifically induces FZD5/8 endocytosis and degradation and the involvement of RSPO-ZNRF3/RNF43 and DVL. Luo D, Zheng J, Lv S, Sheng R, Chen M, He X, Zhang X. bioRxiv [Preprint]. 2024 Oct 18:2024.10.18.619000. doi: 10.1101/2024.10.18.619000. PubMed |
| Manipulation of DHPS activity affects dendritic morphology and expression of synaptic proteins in primary rat cortical neurons. Cavalli P, Raffauf A, Passarella S, Helmuth M, Dieterich DC, Landgraf P. Front Cell Neurosci. 2024 Oct 14;18:1465011. doi: 10.3389/fncel.2024.1465011. eCollection 2024. PubMed |
| Palmitoylation licenses RIPK1 kinase activity and cytotoxicity in the TNF pathway. Zhang N, Liu J, Guo R, Yan L, Yang Y, Shi C, Zhang M, Shan B, Li W, Gu J, Xu D. Mol Cell. 2024 Nov 21;84(22):4419-4435.e10. doi: 10.1016/j.molcel.2024.10.002. Epub 2024 Oct 28. PubMed |
| Inhibiting EZH2 targets atypical teratoid rhabdoid tumor by triggering viral mimicry via both RNA and DNA sensing pathways. Feng S, Marhon SA, Sokolowski DJ, D'Costa A, Soares F, Mehdipour P, Ishak C, Loo Yau H, Ettayebi I, Patel PS, Chen R, Liu J, Zuzarte PC, Ho KC, Ho B, Ning S, Huang A, Arrowsmith CH, Wilson MD, Simpson JT, De Carvalho DD. Nat Commun. 2024 Oct 29;15(1):9321. doi: 10.1038/s41467-024-53515-8. PubMed |
| Deciphering the regulatory mechanisms and biological implications of ARID1A missense mutations in cancer. Liu F, Ying J, Yang K, Xiong X, Yang N, Wang S, Zhao W, Zhu H, Yu M, Wu J, Yang J, Wang X, Sun X. Cell Rep. 2024 Nov 26;43(11):114916. doi: 10.1016/j.celrep.2024.114916. Epub 2024 Oct 30. PubMed |
| DPP an extracellular matrix molecule induces Wnt5a mediated signaling to promote the differentiation of adult stem cells into odontogenic lineage. Chen Y, Petho A, Ganapathy A, George A. Sci Rep. 2024 Oct 31;14(1):26187. doi: 10.1038/s41598-024-76069-7. PubMed |
| Automated live-cell single-molecule tracking in enteroid monolayers reveals transcription factor dynamics probing lineage-determining function. Walther N, Anantakrishnan S, Graham TGW, Dailey GM, Tjian R, Darzacq X. Cell Rep. 2024 Nov 26;43(11):114914. doi: 10.1016/j.celrep.2024.114914. Epub 2024 Oct 30. PubMed |
| Tumor-suppressive activities for pogo transposable element derived with KRAB domain via ribosome biogenesis restriction. Tu Z, Bassal MA, Bell GW, Zhang Y, Hu Y, Quintana LM, Gokul D, Tenen DG, Karnoub AE. Mol Cell. 2024 Nov 7;84(21):4209-4223.e6. doi: 10.1016/j.molcel.2024.09.025. Epub 2024 Oct 30. PubMed |
| A framework for target discovery in rare cancers. Li B, Sadagopan A, Li J, Wu Y, Cui Y, Konda P, Weiss CN, Choueiri TK, Doench JG, Viswanathan SR. bioRxiv [Preprint]. 2024 Nov 20:2024.10.24.620074. doi: 10.1101/2024.10.24.620074. PubMed |
| Suppression of non-muscle myosin II boosts T cell cytotoxicity against tumors. Yang Y, Wen D, Lin F, Song X, Pang R, Sun W, Yu D, Zhang Z, Yu T, Kong J, Zhang L, Cao X, Liao W, Wang D, Yang Q, Liang J, Zhang N, Li K, Xiong C, Liu Y. Sci Adv. 2024 Nov;10(44):eadp0631. doi: 10.1126/sciadv.adp0631. Epub 2024 Nov 1. PubMed |
| Selective degradation of multimeric proteins by TRIM21-based molecular glue and PROTAC degraders. Lu P, Cheng Y, Xue L, Ren X, Xu X, Chen C, Cao L, Li J, Wu Q, Sun S, Hou J, Jia W, Wang W, Ma Y, Jiang Z, Li C, Qi X, Huang N, Han T. Cell. 2024 Dec 12;187(25):7126-7142.e20. doi: 10.1016/j.cell.2024.10.015. Epub 2024 Nov 1. PubMed |
| A LANA peptide inhibits tumor growth by inducing CHD4 protein cleavage and triggers cell death. Miura H, Wang KH, Inagaki T, Chuang F, Shimoda M, Izumiya C, Watanabe T, Davis RR, Tepper CG, Komaki S, Nakajima KI, Kumar A, Izumiya Y. Cell Chem Biol. 2024 Nov 21;31(11):1909-1925.e7. doi: 10.1016/j.chembiol.2024.10.003. Epub 2024 Nov 1. PubMed |
| Extracellular vesicle-packaged PD-L1 impedes macrophage-mediated antibacterial immunity in preexisting malignancy. Zhang HJ, Zhu L, Xie QH, Zhang LZ, Liu JY, Feng YY, Chen ZK, Xia HF, Fu QY, Yu ZL, Chen G. Cell Rep. 2024 Nov 26;43(11):114903. doi: 10.1016/j.celrep.2024.114903. Epub 2024 Oct 28. PubMed |
| Oncolytic viruses alter the biogenesis of tumor extracellular vesicles and influence their immunogenicity. Hirigoyen U, Guilbaud C, Krejbich M, Fouet M, Fresquet J, Arnaud B, Com E, Pineau C, Cadiou G, Burlaud-Gaillard J, Erbs P, Fradin D, Labarriere N, Fonteneau JF, Petithomme T, Boisgerault N. Mol Ther Oncol. 2024 Sep 26;32(4):200887. doi: 10.1016/j.omton.2024.200887. eCollection 2024 Dec 19. PubMed |
| Identification and characterization of host factor VCPIP1 as a multi-functional positive regulator of hepatitis B virus. Kang N, Liu N, Liu M, Zhang S, Yang Y, Hou J, Tan D, Gao Z, Xie Y, Shen Z, Liu J. J Virol. 2024 Dec 17;98(12):e0158124. doi: 10.1128/jvi.01581-24. Epub 2024 Nov 4. PubMed |
| LMAN1 serves as a cargo receptor for thrombopoietin. Everett LA, Lin Z, Friedman A, Tang VT, Myers G, Balbin-Cuesta G, King R, Zhu G, McGee B, Khoriaty R. JCI Insight. 2024 Dec 20;9(24):e175704. doi: 10.1172/jci.insight.175704. PubMed |
| BPDCN MYB fusions regulate cell cycle genes, impair differentiation, and induce myeloid-dendritic cell leukemia. Booth CAG, Bouyssou JM, Togami K, Armand O, Rivas HG, Yan K, Rice S, Cheng S, Lachtara EM, Bourquin JP, Kentsis A, Rheinbay E, DeCaprio JA, Lane AA. JCI Insight. 2024 Dec 20;9(24):e183889. doi: 10.1172/jci.insight.183889. PubMed |
| Type III interferons induce pyroptosis in gut epithelial cells and impair mucosal repair. Jena KK, Mambu J, Boehmer D, Sposito B, Millet V, de Sousa Casal J, Muendlein HI, Spreafico R, Fenouil R, Spinelli L, Wurbel S, Riquier C, Galland F, Naquet P, Chasson L, Elkins M, Mitsialis V, Ketelut-Carneiro N, Bugda Gwilt K, Thiagarajah JR, Ruan HB, Lin Z, Lien E, Shao F, Chou J, Poltorak A, Ordovas-Montanes J, Fitzgerald KA, Snapper SB, Broggi A, Zanoni I. Cell. 2024 Dec 26;187(26):7533-7550.e23. doi: 10.1016/j.cell.2024.10.010. Epub 2024 Nov 4. PubMed |
| Multimodal targeting chimeras enable integrated immunotherapy leveraging tumor-immune microenvironment. Lin F, Yin S, Zhang Z, Yu Y, Fang H, Liang Z, Zhu R, Zhou H, Li J, Cao K, Guo W, Qin S, Zhang Y, Lu C, Li H, Liu S, Zhang H, Ye B, Lin J, Li Y, Kang X, Xi JJ, Chen PR. Cell. 2024 Dec 26;187(26):7470-7491.e32. doi: 10.1016/j.cell.2024.10.016. Epub 2024 Nov 5. PubMed |
| Bioluminescence assay of lysine deacylase sirtuin activity. Van Scoyk AN, Antelope O, Ayer DE, Peterson RT, Pomicter AD, Owen SC, Deininger MW. Cell Chem Biol. 2024 Nov 21;31(11):2002-2014.e4. doi: 10.1016/j.chembiol.2024.10.006. Epub 2024 Nov 7. PubMed |
Rapid parallel reconstruction and specificity screening of hundreds of T cell receptors.
Afeyan AB, Wu CJ, Oliveira G.
Nat Protoc. 2024 Nov 8. doi: 10.1038/s41596-024-01061-4.
PubMed
Associated Plasmids |
| Nuclear receptor E75/NR1D2 promotes tumor malignant transformation by integrating Hippo and Notch pathways. Wang X, Guo Y, Lin P, Yu M, Song S, Xu W, Kong D, Wang Y, Zhang Y, Lu F, Xie Q, Ma X. EMBO J. 2024 Dec;43(24):6336-6363. doi: 10.1038/s44318-024-00290-3. Epub 2024 Nov 8. PubMed |
| A platform of functional studies of ESCC-associated gene mutations identifies the roles of TGFBR2 in ESCC progression and metastasis. Wang J, Du J, Luo X, Guo L, Liu Y, Zhou J, Zou Y, Lu Z, Pan X, Chen X, Zhong A, Wan X, Wang L, Liu H, Dai S, Zhang S, Xiong X, Tan P, Wang M, Wu B, Zhang Q, Wang Y, Zhang M, Lu R, Lin H, Li Y, Li Y, Han Z, Chen L, Hu B, Liu Y, Na F, Chen C. Cell Rep. 2024 Nov 26;43(11):114952. doi: 10.1016/j.celrep.2024.114952. Epub 2024 Nov 10. PubMed |
Transcriptome-scale RNA-targeting CRISPR screens reveal essential lncRNAs in human cells.
Liang WW, Muller S, Hart SK, Wessels HH, Mendez-Mancilla A, Sookdeo A, Choi O, Caragine CM, Corman A, Lu L, Kolumba O, Williams B, Sanjana NE.
Cell. 2024 Dec 26;187(26):7637-7654.e29. doi: 10.1016/j.cell.2024.10.021. Epub 2024 Nov 11.
PubMed
Associated Plasmids |
| ARF alters PAF1 complex integrity to selectively repress oncogenic transcription programs upon p53 loss. Wang J, Fendler NL, Shukla A, Wu SY, Challa A, Lee J, Joachimiak LA, Minna JD, Chiang CM, Vos SM, D'Orso I. Mol Cell. 2024 Dec 5;84(23):4538-4557.e12. doi: 10.1016/j.molcel.2024.10.020. Epub 2024 Nov 11. PubMed |
| Calcium signaling from damaged lysosomes induces cytoprotective stress granules. Duran J, Salinas JE, Wheaton RP, Poolsup S, Allers L, Rosas-Lemus M, Chen L, Cheng Q, Pu J, Salemi M, Phinney B, Ivanov P, Lystad AH, Bhaskar K, Rajaiya J, Perkins DJ, Jia J. EMBO J. 2024 Dec;43(24):6410-6443. doi: 10.1038/s44318-024-00292-1. Epub 2024 Nov 12. PubMed |
| Adaptor protein 3BP2 regulates gene expression in addition to the ubiquitination and proteolytic activity of MALT1 in dectin-1-stimulated cells. Tsubokawa A, Chihara K, Chihara Y, Takeuchi K, Fujieda S, Sada K. J Biol Chem. 2024 Dec;300(12):107980. doi: 10.1016/j.jbc.2024.107980. Epub 2024 Nov 13. PubMed |
Low-affinity ligands of the epidermal growth factor receptor are long-range signal transmitters in collective cell migration of epithelial cells.
Deguchi E, Lin S, Hirayama D, Matsuda K, Tanave A, Sumiyama K, Tsukiji S, Otani T, Furuse M, Sorkin A, Matsuda M, Terai K.
Cell Rep. 2024 Nov 14;43(11):114986. doi: 10.1016/j.celrep.2024.114986.
PubMed
Associated Plasmids |
| Pericancerous cross-presentation to cytotoxic T lymphocytes impairs immunotherapeutic efficacy in hepatocellular carcinoma. Huang CX, Lao XM, Wang XY, Ren YZ, Lu YT, Shi W, Wang YZ, Wu CY, Xu L, Chen MS, Gao Q, Liu L, Wei Y, Kuang DM. Cancer Cell. 2024 Dec 9;42(12):2082-2097.e10. doi: 10.1016/j.ccell.2024.10.012. Epub 2024 Nov 14. PubMed |
| Altered sphingolipid biosynthetic flux and lipoprotein trafficking contribute to trans-fat-induced atherosclerosis. Gengatharan JM, Handzlik MK, Chih ZY, Ruchhoeft ML, Secrest P, Ashley EL, Green CR, Wallace M, Gordts PLSM, Metallo CM. Cell Metab. 2025 Jan 7;37(1):274-290.e9. doi: 10.1016/j.cmet.2024.10.016. Epub 2024 Nov 14. PubMed |
Chemical tools to expand the ligandable proteome: Diversity-oriented synthesis-based photoreactive stereoprobes.
Ogasawara D, Konrad DB, Tan ZY, Carey KL, Luo J, Won SJ, Li H, Carter TR, DeMeester KE, Njomen E, Schreiber SL, Xavier RJ, Melillo B, Cravatt BF.
Cell Chem Biol. 2024 Nov 7:S2451-9456(24)00440-9. doi: 10.1016/j.chembiol.2024.10.005.
PubMed
Associated Plasmids |
| Targeting the aminopeptidase ERAP enhances antitumor immunity by disrupting the NKG2A-HLA-E inhibitory checkpoint. Tsao HW, Anderson S, Finn KJ, Perera JJ, Pass LF, Schneider EM, Jiang A, Fetterman R, Chuong CL, Kozuma K, Stickler MM, Creixell M, Klaeger S, Phulphagar KM, Rachimi S, Verzani EK, Olsson N, Dubrot J, Pech MF, Silkworth W, Lane-Reticker SK, Allen PM, Ibrahim K, Knudsen NH, Cheng AY, Long AH, Ebrahimi-Nik H, Kim SY, Du PP, Iracheta-Vellve A, Robitschek EJ, Suermondt JSMT, Davis TGR, Wolfe CH, Atluri T, Olander KE, Rush JS, Sundberg TB, McAllister FE, Abelin JG, Firestone A, Stokoe D, Carr SA, Harding FA, Yates KB, Manguso RT. Immunity. 2024 Dec 10;57(12):2863-2878.e12. doi: 10.1016/j.immuni.2024.10.013. Epub 2024 Nov 18. PubMed |
| Human genetics identify convergent signals in mitochondrial LACTB-mediated lipid metabolism in cardiovascular-kidney-metabolic syndrome. Li S, Liu H, Hu H, Ha E, Prasad P, Jenkins BC, Das US, Mukherjee S, Shishikura K, Hu R, Rader DJ, Pei L, Baur JA, Matthews ML, FitzGerald GA, McReynolds MR, Susztak K. Cell Metab. 2025 Jan 7;37(1):154-168.e7. doi: 10.1016/j.cmet.2024.10.007. Epub 2024 Nov 18. PubMed |
| Crosstalk between paralogs and isoforms influences p63-dependent regulatory element activity. Baniulyte G, McCann AA, Woodstock DL, Sammons MA. Nucleic Acids Res. 2024 Dec 11;52(22):13812-13831. doi: 10.1093/nar/gkae1143. PubMed |
| Host specific sphingomyelin is critical for replication of diverse RNA viruses. Han S, Ye X, Yang J, Peng X, Jiang X, Li J, Zheng X, Zhang X, Zhang Y, Zhang L, Wang W, Li J, Xin W, Zhang X, Xiao G, Peng K, Zhang L, Du X, Zhou L, Liu W, Li H. Cell Chem Biol. 2024 Dec 19;31(12):2052-2068.e11. doi: 10.1016/j.chembiol.2024.10.009. Epub 2024 Nov 19. PubMed |
| Gliocidin is a nicotinamide-mimetic prodrug that targets glioblastoma. Chen YJ, Iyer SV, Hsieh DC, Li B, Elias HK, Wang T, Li J, Ganbold M, Lien MC, Peng YC, Xie XP, Jayewickreme CD, van den Brink MRM, Brady SF, Lim SK, Parada LF. Nature. 2024 Dec;636(8042):466-473. doi: 10.1038/s41586-024-08224-z. Epub 2024 Nov 20. PubMed |
| A pan-family screen of nuclear receptors in immunocytes reveals ligand-dependent inflammasome control. Wang Y, Zhang Y, Kim K, Han J, Okin D, Jiang Z, Yang L, Subramaniam A, Means TK, Nestle FO, Fitzgerald KA, Randolph GJ, Lesser CF, Kagan JC, Mathis D, Benoist C. Immunity. 2024 Dec 10;57(12):2737-2754.e12. doi: 10.1016/j.immuni.2024.10.010. Epub 2024 Nov 20. PubMed |
| Cancer cells restrict immunogenicity of retrotransposon expression via distinct mechanisms. Sun S, You E, Hong J, Hoyos D, Del Priore I, Tsanov KM, Mattagajasingh O, Di Gioacchino A, Marhon SA, Chacon-Barahona J, Li H, Jiang H, Hozeifi S, Rosas-Bringas O, Xu KH, Song Y, Lang ER, Rojas AS, Nieman LT, Patel BK, Murali R, Chanda P, Karacay A, Vabret N, De Carvalho DD, Zenklusen D, LaCava J, Lowe SW, Ting DT, Iacobuzio-Donahue CA, Solovyov A, Greenbaum BD. Immunity. 2024 Dec 10;57(12):2879-2894.e11. doi: 10.1016/j.immuni.2024.10.015. Epub 2024 Nov 21. PubMed |
Interleukin-1alpha release during necrotic-like cell death generates myeloid-driven immunosuppression that restricts anti-tumor immunity.
Hanggi K, Li J, Gangadharan A, Liu X, Celias DP, Osunmakinde O, Keske A, Davis J, Ahmad F, Giron A, Anadon CM, Gardner A, DeNardo DG, Shaw TI, Beg AA, Yu X, Ruffell B.
Cancer Cell. 2024 Nov 13:S1535-6108(24)00402-1. doi: 10.1016/j.ccell.2024.10.014.
PubMed
Associated Plasmids |
| Inceptor binds to and directs insulin towards lysosomal degradation in beta cells. Siehler J, Bilekova S, Chapouton P, Dema A, Albanese P, Tamara S, Jain C, Sterr M, Enos SJ, Chen C, Malhotra C, Villalba A, Schomann L, Bhattacharya S, Feng J, Akgun Canan M, Ribaudo F, Ansarullah, Burtscher I, Ahlbrecht C, Plettenburg O, Kurth T, Scharfmann R, Speier S, Scheltema RA, Lickert H. Nat Metab. 2024 Dec;6(12):2374-2390. doi: 10.1038/s42255-024-01164-y. Epub 2024 Nov 25. PubMed |
| Breast Cancer Subtype-Specific Organotropism Is Dictated by FOXF2-Regulated Metastatic Dormancy and Recovery. Jiang WJ, Zhou TH, Huang HJ, Li LS, Tan H, Zhang R, Wang QS, Feng YM. Cancer Res. 2025 Feb 17;85(4):644-659. doi: 10.1158/0008-5472.CAN-24-0479. PubMed |
Glucose limitation protects cancer cells from apoptosis induced by pyrimidine restriction and replication inhibition.
Nam M, Xia W, Mir AH, Jerrett A, Spinelli JB, Huang TT, Possemato R.
Nat Metab. 2024 Dec;6(12):2338-2353. doi: 10.1038/s42255-024-01166-w. Epub 2024 Nov 26.
PubMed
Associated Plasmids |
| DNA Methylation in the CYP3A Distal Regulatory Region (DRR) Is Associated with the Expression of CYP3A5 and CYP3A7 in Human Liver Samples. Collins JM, Wang D. Molecules. 2024 Nov 16;29(22):5407. doi: 10.3390/molecules29225407. PubMed |
| A Novel Tax-Responsive Reporter T-Cell Line to Analyze Infection of HTLV-1. Heym S, Krebs P, Ott K, Donhauser N, Kemeter LM, Simon F, Millen S, Thoma-Kress AK. Pathogens. 2024 Nov 19;13(11):1015. doi: 10.3390/pathogens13111015. PubMed |
| Blocking WNT7A Enhances MHC-I Antigen Presentation and Enhances the Effectiveness of Immune Checkpoint Blockade Therapy. Sun J, Wang P, Yi Z, Wu Y, Wei Y, Fang H, Song D, Chen Y, Du H, Huang J, Li Q, Yang D, Ren G, Li H. Cancer Immunol Res. 2025 Mar 4;13(3):400-416. doi: 10.1158/2326-6066.CIR-24-0484. PubMed |
| UHRF1 ubiquitin ligase activity supports the maintenance of low-density CpG methylation. Tiedemann RL, Hrit J, Du Q, Wiseman AK, Eden HE, Dickson BM, Kong X, Chomiak AA, Vaughan RM, Tibben BM, Hebert JM, David Y, Zhou W, Baylin SB, Jones PA, Clark SJ, Rothbart SB. Nucleic Acids Res. 2024 Dec 11;52(22):13733-13756. doi: 10.1093/nar/gkae1105. PubMed |
| Phase separation of chimeric antigen receptor promotes immunological synapse maturation and persistent cytotoxicity. Xu X, Chen H, Ren Z, Xu X, Wu W, Yang H, Wang J, Zhang Y, Zhou Q, Li H, Zhang S, Wang H, Xu C. Immunity. 2024 Dec 10;57(12):2755-2771.e8. doi: 10.1016/j.immuni.2024.11.005. Epub 2024 Nov 27. PubMed |
| Kinome-wide CRISPR-Cas9 screens revealed EXOSC10 as a positive regulator of TGF-beta signaling. Wang D, Zhang X, Guo J, Liu W, Zhou Y, Wang R. Biochem Biophys Rep. 2024 Nov 12;40:101864. doi: 10.1016/j.bbrep.2024.101864. eCollection 2024 Dec. PubMed |
| Claudin-4 Stabilizes the Genome via Nuclear and Cell-Cycle Remodeling to Support Ovarian Cancer Cell Survival. Villagomez FR, Lang J, Nunez-Avellaneda D, Behbakht K, Dimmick HL, Webb PG, Nephew KP, Neville M, Woodruff ER, Bitler BG. Cancer Res Commun. 2025 Jan 1;5(1):39-53. doi: 10.1158/2767-9764.CRC-24-0558. PubMed |
| Widespread neuroanatomical integration and distinct electrophysiological properties of glioma-innervating neurons. Hsieh AL, Ganesh S, Kula T, Irshad M, Ferenczi EA, Wang W, Chen YC, Hu SH, Li Z, Joshi S, Haigis MC, Sabatini BL. Proc Natl Acad Sci U S A. 2024 Dec 10;121(50):e2417420121. doi: 10.1073/pnas.2417420121. Epub 2024 Dec 4. PubMed |
| Single-cell analysis reveals host S phase drives large T antigen expression during BK polyomavirus infection. Needham JM, Perritt SE, Thompson SR. PLoS Pathog. 2024 Dec 5;20(12):e1012663. doi: 10.1371/journal.ppat.1012663. eCollection 2024 Dec. PubMed |
| Optimized reporters for multiplexed detection of transcription factor activity. Trauernicht M, Filipovska T, Rastogi C, van Steensel B. Cell Syst. 2024 Dec 18;15(12):1107-1122.e7. doi: 10.1016/j.cels.2024.11.003. Epub 2024 Dec 6. PubMed |
| Gain-of-Function Chromatin Remodeling Activity of Oncogenic FOXL2C134W Reprograms Glucocorticoid Receptor Occupancy to Drive Granulosa Cell Tumors. Welte T, Vuttaradhi VK, Khlebus EY, Brodsky A, Flores Legarreta A, Celestino J, Powell RT, Stephan CC, Nguyen N, Li J, Takamatsu S, Calzoncinth K, Sood AK, Gershenson DM, Futreal PA, Lawson B, Hillman RT. Cancer Res. 2025 Mar 3;85(5):875-893. doi: 10.1158/0008-5472.CAN-24-2341. PubMed |
| Fusobacterium nucleatum promotes colorectal cancer through neogenesis of tumor stem cells. Wang Q, Hu T, Zhang Q, Zhang Y, Dong X, Jin Y, Li J, Guo Y, Guo F, Chen Z, Zhong P, Yang Y, Ma Y. J Clin Invest. 2025 Feb 3;135(3):e181595. doi: 10.1172/JCI181595. PubMed |
Restricting lysine normalizes toxic catabolites associated with ALDH7A1 deficiency in cells and mice.
Johal AS, Al-Shekaili HH, Abedrabbo M, Kehinde AZ, Towriss M, Koe JC, Hewton KG, Thomson SB, Ciernia AV, Leavitt B, Parker SJ.
Cell Rep. 2024 Dec 24;43(12):115069. doi: 10.1016/j.celrep.2024.115069. Epub 2024 Dec 10.
PubMed
Associated Plasmids |
| Mitochondrial transplantation rescues Ca(2+) homeostasis imbalance and myocardial hypertrophy in SLC25A3-related hypertrophic cardiomyopathy. Li S, Zhang J, Fu W, Cao J, Li Z, Tian X, Yang M, Zhao J, Wang C, Liu Y, Liu M, Zhao X, Li X, Dong J, Qi Y. Cell Rep. 2024 Dec 24;43(12):115065. doi: 10.1016/j.celrep.2024.115065. Epub 2024 Dec 12. PubMed |
| Nzf2 promotes oligodendrocyte differentiation and regeneration via repressing HDAC1-mediated histone deacetylation. Xu X, Fang M, Chen L, Huang H, Dai ZM, Yang J, Qiu M. Sci Adv. 2024 Dec 13;10(50):eadf8405. doi: 10.1126/sciadv.adf8405. Epub 2024 Dec 13. PubMed |
| Inhibiting intracellular CD28 in cancer cells enhances antitumor immunity and overcomes anti-PD-1 resistance via targeting PD-L1. Yang Z, Liu X, Zhu J, Chai Y, Cong B, Li B, Gao W, Hu Y, Wen M, Liu Y, Fu L, Cao X. Cancer Cell. 2025 Jan 13;43(1):86-102.e10. doi: 10.1016/j.ccell.2024.11.008. Epub 2024 Dec 12. PubMed |
| Daily glucocorticoids promote glioblastoma growth and circadian synchrony to the host. Gonzalez-Aponte MF, Damato AR, Simon T, Aripova N, Darby F, Jeon MS, Luo J, Rubin JB, Herzog ED. Cancer Cell. 2025 Jan 13;43(1):144-160.e7. doi: 10.1016/j.ccell.2024.11.012. Epub 2024 Dec 12. PubMed |
| Canonical androgen response element motifs are tumor suppressive regulatory elements in the prostate. Chen X, Augello MA, Liu D, Lin K, Hakansson A, Sjostrom M, Khani F, Deonarine LD, Liu Y, Travascio-Green J, Wu J, Chan UI, Owiredu J, Loda M, Feng FY, Robinson BD, Davicioni E, Sboner A, Barbieri CE. Nat Commun. 2024 Dec 13;15(1):10675. doi: 10.1038/s41467-024-53734-z. PubMed |
| Control of Epithelial Tissue Organization by mRNA Localization. Mason DE, Madsen TD, Gasparski AN, Jiwnani N, Lechler T, Weigert R, Iglesias-Bartolome R, Mili S. bioRxiv [Preprint]. 2024 Dec 2:2024.12.02.626432. doi: 10.1101/2024.12.02.626432. PubMed |
| Ubiquitin Ligase ITCH Regulates Life Cycle of SARS-CoV-2 Virus. Xiang Q, Wouters C, Chang P, Lu YN, Liu M, Wang H, Yang J, Pekosz A, Zhang Y, Wang J. bioRxiv [Preprint]. 2024 Dec 5:2024.12.04.624804. doi: 10.1101/2024.12.04.624804. PubMed |
| Molecular Insights into the Regulation of GNPTAB by TMEM251. Yang X, Doray B, Venkatarangan V, Jennings BC, Henn D, Liang J, Zhao H, Zhang W, Zhang B, Yu L, Chen L, Kornfeld S, Li M. bioRxiv [Preprint]. 2024 Dec 5:2024.12.05.627003. doi: 10.1101/2024.12.05.627003. PubMed |
| SLMO transfers phosphatidylserine between the outer and inner mitochondrial membrane in Drosophila. Zhao S, Jiang X, Li N, Wang T. PLoS Biol. 2024 Dec 16;22(12):e3002941. doi: 10.1371/journal.pbio.3002941. eCollection 2024 Dec. PubMed |
| A High-Throughput Neurosphere-Based Colony Formation Assay to Test Drug and Radiation Sensitivity of Different Patient-Derived Glioblastoma Lines. Kumar M, Nassour-Caswell LC, Alrefai H, Anderson JC, Schanel TL, Hicks PH, Cardan R, Willey CD. Cells. 2024 Dec 3;13(23):1995. doi: 10.3390/cells13231995. PubMed |
| Broccoli Sprout Extract Suppresses Particulate-Matter-Induced Matrix-Metalloproteinase (MMP)-1 and Cyclooxygenase (COX)-2 Expression in Human Keratinocytes by Direct Targeting of p38 MAP Kinase. Yun J, Kim JE. Nutrients. 2024 Nov 30;16(23):4156. doi: 10.3390/nu16234156. PubMed |
| An Unbiased Approach to Identifying Cellular Reprogramming-Inducible Enhancers. Klagkou E, Valakos D, Foutadakis S, Polyzos A, Papadopoulou A, Vatsellas G, Thanos D. Int J Mol Sci. 2024 Dec 6;25(23):13128. doi: 10.3390/ijms252313128. PubMed |
| Multiome Perturb-seq unlocks scalable discovery of integrated perturbation effects on the transcriptome and epigenome. Metzner E, Southard KM, Norman TM. Cell Syst. 2025 Jan 15;16(1):101161. doi: 10.1016/j.cels.2024.12.002. Epub 2024 Dec 16. PubMed |
| CPNE7 promotes colorectal tumorigenesis by interacting with NONO to initiate ZFP42 transcription. Zhao L, Sun X, Hou C, Yang Y, Wang P, Xu Z, Chen Z, Zhang X, Wu G, Chen H, Xing H, Xie H, He L, Jin S, Liu B. Cell Death Dis. 2024 Dec 18;15(12):896. doi: 10.1038/s41419-024-07288-z. PubMed |
| USP39 regulates pyruvate handling in non-small cell lung cancer. Becirovic T, Zhang B, Vakifahmetoglu-Norberg H, Kaminskyy VO, Kochetkova E, Norberg E. Cell Death Discov. 2024 Dec 18;10(1):502. doi: 10.1038/s41420-024-02264-0. PubMed |
| Overexpression of ELF3 in the PTEN-deficient lung epithelium promotes lung cancer development by inhibiting ferroptosis. Yuan Z, Han X, Xiao M, Zhu T, Xu Y, Tang Q, Lian C, Wang Z, Li J, Wang B, Li C, Xiang X, Jin R, Liu Y, Yu X, Zhang K, Li S, Ray M, Li R, Gruzdev A, Shao S, Shao F, Wang H, Lian W, Tang Y, Chen D, Lei Y, Jin X, Li Q, Long W, Huang H, DeMayo FJ, Liu J. Cell Death Dis. 2024 Dec 18;15(12):897. doi: 10.1038/s41419-024-07274-5. PubMed |
| MACC1 ablation suppresses the dedifferentiation process of non-CSCs in lung cancer through stabilizing KLF4. Li Z, Wang S, Guo T, Yan X, Chen C, Zhang W, Zhao J, Zhang J, Zhao S, Wang Y, Qi Y, Gu C. Cell Death Discov. 2024 Dec 18;10(1):494. doi: 10.1038/s41420-024-02256-0. PubMed |
| Selenoprotein O Promotes Melanoma Metastasis and Regulates Mitochondrial Complex II Activity. Nascentes Melo LM, Sabatier M, Ramesh V, Szylo KJ, Fraser CS, Pon A, Mitchell EC, Servage KA, Allies G, Westedt IV, Cansiz F, Krystkiewicz J, Kutritz A, Schadendorf D, Morrison SJ, Ubellacker JM, Sreelatha A, Tasdogan A. Cancer Res. 2025 Mar 3;85(5):942-955. doi: 10.1158/0008-5472.CAN-23-2194. PubMed |
| Modeling vascular dynamics at the initial stage of endochondral ossification on a microfluidic chip using a human embryonic-stem-cell-derived organoid. Kesharwani A, Tani S, Nishikawa M, Sakai Y, Okada H, Ohba S, Chung UI, Hojo H. Regen Ther. 2024 Dec 4;28:90-100. doi: 10.1016/j.reth.2024.11.018. eCollection 2025 Mar. PubMed |
| Cancer mutations rewire the RNA methylation specificity of METTL3-METTL14. Zhang C, Scott RL, Tunes L, Hsieh MH, Wang P, Kumar A, Khadgi BB, Yang YY, Doxtader Lacy KA, Herrell E, Zhang X, Evers B, Wang Y, Xing C, Zhu H, Nam Y. Sci Adv. 2024 Dec 20;10(51):eads4750. doi: 10.1126/sciadv.ads4750. Epub 2024 Dec 20. PubMed |
| Glutathione peroxidase 4 overexpression induces anomalous subdiffusion and impairs glioblastoma cell growth. Teferi N, Ekanayake A, Owusu SB, Moninger TO, Sarkaria JN, Tivanski AV, Petronek MS. J Biol Eng. 2024 Dec 21;18(1):72. doi: 10.1186/s13036-024-00472-x. PubMed |
| TGFbeta signaling sensitizes MEKi-resistant human melanoma to targeted therapy-induced apoptosis. Loos B, Salas-Bastos A, Nordin A, Debbache J, Stierli S, Cheng PF, Rufli S, Wyss C, Levesque MP, Dummer R, Wong WW, Pascolo S, Cantu C, Sommer L. Cell Death Dis. 2024 Dec 21;15(12):925. doi: 10.1038/s41419-024-07305-1. PubMed |
| Transcription factors form a ternary complex with NIPBL/MAU2 to localize cohesin at enhancers. Fettweis G, Wagh K, Stavreva DA, Jimenez-Panizo A, Kim S, Lion M, Alegre-Marti A, Rinaldi L, Johnson TA, Krishnamurthy M, Wang L, Ball DA, Karpova TS, Upadhyaya A, Vertommen D, Recio JF, Estebanez-Perpina E, Dequiedt F, Hager GL. bioRxiv [Preprint]. 2025 Feb 19:2024.12.09.627537. doi: 10.1101/2024.12.09.627537. PubMed |
| Programming the elongation of mammalian cell aggregates with synthetic gene circuits. Courte J, Chung C, Jain N, Salazar C, Phuchane N, Grosser S, Lam C, Morsut L. bioRxiv [Preprint]. 2024 Dec 11:2024.12.11.627621. doi: 10.1101/2024.12.11.627621. PubMed |
| Nuclear Control of Mitochondrial Homeostasis and Venetoclax Efficacy in AML via COX4I1. Zhang L, Zhang H, Wang TY, Li M, Chan AKN, Kang H, Foong LC, Liu Q, Pokharel SP, Mattson NM, Singh P, Elsayed Z, Kuang B, Wang X, Rosen ST, Chen J, Yang L, Chou TF, Su R, Chen CD. Adv Sci (Weinh). 2025 Feb;12(6):e2404620. doi: 10.1002/advs.202404620. Epub 2024 Dec 23. PubMed |
| T-cadherin modulates adipogenic differentiation in mesenchymal stem cells: insights into ligand interactions. Sysoeva V, Semina E, Klimovich P, Kulebyakin K, Dzreyan V, Sotskaya E, Shchipova A, Popov V, Shilova A, Brodsky I, Khabibullin N, Voloshin N, Tkachuk V, Rubina K. Front Cell Dev Biol. 2024 Dec 9;12:1446363. doi: 10.3389/fcell.2024.1446363. eCollection 2024. PubMed |
| RBIS regulates ribosome biogenesis to affect progression in lung adenocarcinoma. Pan H, Liao L, Xu S, Xu Y, Chai W, Liu X, Li J, Cao Y, Sun L, Liu Q, Yan M. J Transl Med. 2024 Dec 25;22(1):1147. doi: 10.1186/s12967-024-05886-1. PubMed |
| Upregulated YTHDC1 mediates trophoblastic dysfunction inducing preterm birth in ART conceptions through enhanced RPL37 translation. Li W, Zhang Q, Ni M, Li B, Chen Z, Shen Q, Lin Z, Cheng C, Yao D, Qi S, Ding X, Shen H, Liu X, Tang Z, Huang X, Zhao J, Liu Z. Cell Mol Life Sci. 2024 Dec 27;82(1):17. doi: 10.1007/s00018-024-05467-x. PubMed |
| Mechanism of enhancing chemotherapy efficacy in pancreatic ductal adenocarcinoma with paricalcitol and hydroxychloroquine. Nagaraju GP, Saddala MS, Foote JB, Khaliq AM, Masood A, Golivi Y, Bandi DSR, Sarvesh S, Reddy SP, Switchenko J, Carstens JL, Akce M, Herting C, Alese OB, Yoon KJ, Manne U, Bhasin MK, Lesinski GB, Sukhatme VP, El-Rayes BF. Cell Rep Med. 2025 Jan 21;6(1):101881. doi: 10.1016/j.xcrm.2024.101881. Epub 2024 Dec 26. PubMed |
| Targeting mitochondrial RNAs enhances the efficacy of the DNA-demethylating agents. Tan S, Kim S, Kim Y. Sci Rep. 2024 Dec 28;14(1):30767. doi: 10.1038/s41598-024-80834-z. PubMed |
| Efficacy of glutathione inhibitor eprenetapopt against the vulnerability of glutathione metabolism in SMARCA4-, SMARCB1- and PBRM1-deficient cancer cells. Sasaki M, Ogiwara H. Sci Rep. 2024 Dec 28;14(1):31321. doi: 10.1038/s41598-024-82753-5. PubMed |
| Loss of YTHDC1 m(6)A reading function promotes invasiveness in urothelial carcinoma of the bladder. Xu J, Koch J, Schmidt C, Nientiedt M, Neuberger M, Erben P, Michel MS, Rodriguez-Paredes M, Lyko F. Exp Mol Med. 2025 Feb;57(1):118-130. doi: 10.1038/s12276-024-01377-x. Epub 2025 Jan 1. PubMed |
| Co-essentiality analysis identifies PRR12 as a cohesin interacting protein and contributor to genomic integrity. Nguyen AL, Smith EM, Cheeseman IM. Dev Cell. 2025 Apr 21;60(8):1217-1233.e7. doi: 10.1016/j.devcel.2024.12.015. Epub 2024 Dec 31. PubMed |
| Tau is a receptor with low affinity for glucocorticoids and is required for glucocorticoid-induced bone loss. Fu W, Chen M, Wang K, Chen Y, Cui Y, Xie Y, Lei ZN, Hu W, Sun G, Huang G, He C, Fretz J, Hettinghouse A, Liu R, Cai X, Zhang M, Chen Y, Jiang N, He M, Wiznia DH, Xu H, Chen ZS, Chen L, Tang K, Zhou H, Liu CJ. Cell Res. 2025 Jan;35(1):23-44. doi: 10.1038/s41422-024-01016-0. Epub 2025 Jan 2. PubMed |
| Oncogenic RARgamma isoforms promote head and neck cancer proliferation through vinexin-beta-mediated cell cycle acceleration and autocrine activation of EGFR signal. Su YC, Wu SY, Hsu KF, Jiang SS, Kuo PC, Shiau AL, Wu CL, Wang YK, Hsiao JR. Int J Biol Sci. 2025 Jan 1;21(1):1-16. doi: 10.7150/ijbs.100351. eCollection 2025. PubMed |
| Long non-coding RNAs direct the SWI/SNF complex to cell type-specific enhancers. Oo JA, Warwick T, Palfi K, Lam F, McNicoll F, Prieto-Garcia C, Gunther S, Cao C, Zhou Y, Gavrilov AA, Razin SV, Cabrera-Orefice A, Wittig I, Pullamsetti SS, Kurian L, Gilsbach R, Schulz MH, Dikic I, Muller-McNicoll M, Brandes RP, Leisegang MS. Nat Commun. 2025 Jan 2;16(1):131. doi: 10.1038/s41467-024-55539-6. PubMed |
| Inhalable nanovesicles loaded with a STING agonist enhance CAR-T cell activity against solid tumors in the lung. Zhu T, Xiao Y, Chen Z, Ding H, Chen S, Jiang G, Huang X. Nat Commun. 2025 Jan 2;16(1):262. doi: 10.1038/s41467-024-55751-4. PubMed |
| Constitutive activation of the Src-family kinases Fgr and Hck enhances the tumor burden of acute myeloid leukemia cells in immunocompromised mice. Shu ST, Chen L, Gonzalez-Areizaga G, Smithgall TE. Sci Rep. 2025 Jan 2;15(1):174. doi: 10.1038/s41598-024-83740-6. PubMed |
| TRIM32 regulates insulin sensitivity by controlling insulin receptor degradation in the liver. Thakur S, Rawat P, Dehury B, Mondal P. EMBO Rep. 2025 Feb;26(3):791-809. doi: 10.1038/s44319-024-00348-7. Epub 2025 Jan 2. PubMed |
| Viral oncogene EBNALP regulates YY1 DNA binding and alters host 3D genome organization. Wang C, Leong MM, Ding W, Narita Y, Liu X, Wang H, Yiu SPT, Lee J, Zhao KRS, Cui A, Gewurz B, Hammerschmidt W, Teng M, Zhao B. EMBO Rep. 2025 Feb;26(3):810-835. doi: 10.1038/s44319-024-00357-6. Epub 2025 Jan 2. PubMed |
| Positive feedback between arginine methylation of YAP and methionine transporter SLC43A2 drives anticancer drug resistance. Hong XL, Huang CK, Qian H, Ding CH, Liu F, Hong HY, Liu SQ, Wu SH, Zhang X, Xie WF. Nat Commun. 2025 Jan 2;16(1):87. doi: 10.1038/s41467-024-55769-8. PubMed |
| MCTS2 and distinct eIF2D roles in uORF-dependent translation regulation revealed by in vitro re-initiation assays. Meurs R, De Matos M, Bothe A, Guex N, Weber T, Teleman AA, Ban N, Gatfield D. EMBO J. 2025 Feb;44(3):854-876. doi: 10.1038/s44318-024-00347-3. Epub 2025 Jan 2. PubMed |
| Tau phosphorylation suppresses oxidative stress-induced mitophagy via FKBP8 receptor modulation. Isei MO, Crockett M, Chen E, Rodwell-Bullock J, Carroll T, Girardi PA, Nehrke K, Johnson GVW. PLoS One. 2025 Jan 3;20(1):e0307358. doi: 10.1371/journal.pone.0307358. eCollection 2025. PubMed |
| Hepatitis B virus hijacks MRE11-RAD50-NBS1 complex to form its minichromosome. Zhao K, Wang J, Wang Z, Wang M, Li C, Xu Z, Zhan Q, Guo F, Cheng X, Xia Y. PLoS Pathog. 2025 Jan 3;21(1):e1012824. doi: 10.1371/journal.ppat.1012824. eCollection 2025 Jan. PubMed |
| Systematic functional characterization of non-coding regulatory SNPs associated with central obesity. Dong SS, Duan YY, Zhu RJ, Jia YY, Chen JX, Huang XT, Tang SH, Yu K, Shi W, Chen XF, Jiang F, Hao RH, Liu Y, Liu Z, Guo Y, Yang TL. Am J Hum Genet. 2025 Jan 2;112(1):116-134. doi: 10.1016/j.ajhg.2024.11.005. PubMed |
| Circulating tumor cell plasticity determines breast cancer therapy resistance via neuregulin 1-HER3 signaling. Wurth R, Donato E, Michel LL, Saini M, Becker L, Cheytan T, Doncevic D, Messmer T, Gutjahr E, Weber R, Klein C, Alborzinia H, Yildiz U, Vogel V, Hlevnjak M, Kozyulina P, Neuberth SJ, Schwerd-Kleine P, Jakab S, Pfarr N, Angeles AK, Laut AK, Karpova D, Falcone M, Hardt O, Theek B, Wagner CV, Becker M, Wagner S, Haselmayr M, Schmitt A, Muller-Tidow C, Riethdorf S, Pantel K, Zapatka M, Sultmann H, Herrmann C, Thewes V, Lichter P, Schneeweiss A, Sprick MR, Trumpp A. Nat Cancer. 2025 Jan;6(1):67-85. doi: 10.1038/s43018-024-00882-2. Epub 2025 Jan 3. PubMed |
| The proximity-based protein interactome and regulatory logics of the transcription factor p65 NF-kappaB/RELA. Leib L, Juli J, Jurida L, Mayr-Buro C, Priester J, Weiser H, Wirth S, Hanel S, Heylmann D, Weber A, Schmitz ML, Papantonis A, Bartkuhn M, Wilhelm J, Linne U, Meier-Soelch J, Kracht M. EMBO Rep. 2025 Feb;26(4):1144-1183. doi: 10.1038/s44319-024-00339-8. Epub 2025 Jan 3. PubMed |
| Nonhuman primate antigenic cartography of SARS-CoV-2. Rossler A, Netzl A, Lasrado N, Chaudhari J, Muhlemann B, Wilks SH, Kimpel J, Smith DJ, Barouch DH. Cell Rep. 2025 Jan 28;44(1):115140. doi: 10.1016/j.celrep.2024.115140. Epub 2025 Jan 3. PubMed |
| Gut microbiota protect against colorectal tumorigenesis through lncRNA Snhg9. Wang M, Liu K, Bao W, Hang B, Chen X, Zhu X, Li G, Liu L, Xiang H, Hu H, Lu Y, Song Z, Chen J, Wang Y. Dev Cell. 2025 Apr 7;60(7):1008-1017.e7. doi: 10.1016/j.devcel.2024.12.013. Epub 2025 Jan 3. PubMed |
| SLC7A5 is required for cancer cell growth under arginine-limited conditions. Dunlap KN, Bender A, Bowles A, Bott AJ, Tay J, Grossmann AH, Rutter J, Ducker GS. Cell Rep. 2025 Jan 28;44(1):115130. doi: 10.1016/j.celrep.2024.115130. Epub 2025 Jan 3. PubMed |
| Fate erasure logic of gene networks underlying direct neuronal conversion of somatic cells by microRNAs. Cates K, Yuan L, Yang Y, Yoo AS. Cell Rep. 2025 Jan 28;44(1):115153. doi: 10.1016/j.celrep.2024.115153. Epub 2025 Jan 4. PubMed |
| RACK1 MARylation regulates translation and stress granules in ovarian cancer cells. Challa S, Nandu T, Kim HB, Gong X, Renshaw CW, Li WC, Tan X, Aljardali MW, Camacho CV, Chen J, Kraus WL. J Cell Biol. 2025 Feb 3;224(2):e202401101. doi: 10.1083/jcb.202401101. Epub 2025 Jan 6. PubMed |
Transsulfuration pathway activation attenuates oxidative stress and ferroptosis in sickle primary erythroblasts and transgenic mice.
Xi C, Pang J, Xue W, Cui Y, Jiang N, Zhi W, Shi H, Horuzsko A, Pace BS, Zhu X.
Commun Biol. 2025 Jan 6;8(1):15. doi: 10.1038/s42003-024-07424-7.
PubMed
Associated Plasmids |
| G6PD deficiency triggers dopamine loss and the initiation of Parkinson's disease pathogenesis. Stykel MG, Siripala SV, Soubeyrand E, Coackley CL, Lu P, Camargo S, Thevasenan S, Figueroa GB, So RWL, Stuart E, Panchal R, Akrioti EK, Joseph JT, Haji-Ghassemi O, Taoufik E, Akhtar TA, Watts JC, Ryan SD. Cell Rep. 2025 Jan 28;44(1):115178. doi: 10.1016/j.celrep.2024.115178. Epub 2025 Jan 7. PubMed |
| Photophysics-informed two-photon voltage imaging using FRET-opsin voltage indicators. Brooks FP 3rd, Gong D, Davis HC, Park P, Qi Y, Cohen AE. Sci Adv. 2025 Jan 10;11(2):eadp5763. doi: 10.1126/sciadv.adp5763. Epub 2025 Jan 8. PubMed |
| Chlamydia trachomatis impairs T cell priming by inducing dendritic cell death. Mao H, Dumas EK, Starnbach MN. Infect Immun. 2025 Feb 18;93(2):e0040224. doi: 10.1128/iai.00402-24. Epub 2025 Jan 8. PubMed |
| hnRNPU-mediated pathogenic alternative splicing drives gastric cancer progression. Jin G, Song Y, Fang S, Yan M, Yang Z, Shao Y, Zhao K, Liu M, Wang Z, Guo Z, Dong Z. J Exp Clin Cancer Res. 2025 Jan 7;44(1):8. doi: 10.1186/s13046-024-03264-9. PubMed |
| Inosine monophosphate dehydrogenase 2 (IMPDH2) modulates response to therapy and chemo-resistance in triple negative breast cancer. da Silva Fernandes T, Gillard BM, Dai T, Martin JC, Chaudhry KA, Dugas SM, Fisher AA, Sharma P, Wu R, Attwood KM, Dasgupta S, Takabe K, Rosario SR, Bianchi-Smiraglia A. Sci Rep. 2025 Jan 7;15(1):1061. doi: 10.1038/s41598-024-85094-5. PubMed |
| Single-molecule analysis reveals that IPMK enhances the DNA-binding activity of the transcription factor SRF. Ahn H, Yu J, Ryu K, Ryu J, Kim S, Park JY, Kim JK, Jung I, An H, Hong S, Kim E, Park K, Ahn M, Min S, Jung I, Lee D, Lee T, Byun Y, Song JJ, Kim J, Cho WK, Lee G, Kim S. Nucleic Acids Res. 2025 Jan 7;53(1):gkae1281. doi: 10.1093/nar/gkae1281. PubMed |
| KLF5 loss sensitizes cells to ATR inhibition and is synthetic lethal with ARID1A deficiency. Awwad SW, Doyle C, Coulthard J, Bader AS, Gueorguieva N, Lam S, Gupta V, Belotserkovskaya R, Tran TA, Balasubramanian S, Jackson SP. Nat Commun. 2025 Jan 8;16(1):480. doi: 10.1038/s41467-024-55637-5. PubMed |
| Intestinal TM6SF2 protects against metabolic dysfunction-associated steatohepatitis through the gut-liver axis. Zhang X, Lau HC, Ha S, Liu C, Liang C, Lee HW, Ng QW, Zhao Y, Ji F, Zhou Y, Pan Y, Song Y, Zhang Y, Lo JCY, Cheung AHK, Wu J, Li X, Xu H, Wong CC, Wong VW, Yu J. Nat Metab. 2025 Jan;7(1):102-119. doi: 10.1038/s42255-024-01177-7. Epub 2025 Jan 8. PubMed |
| alpha-catenin phosphorylation is elevated during mitosis to resist apical rounding and epithelial barrier leak. Le PM, Quinn JM, Flozak AS, Steffeck AWT, Huang CF, Gottardi CJ. Biol Open. 2025 Jan 15;14(1):bio061726. doi: 10.1242/bio.061726. Epub 2025 Jan 8. PubMed |
| RNF7-Mediated ROS Targets Malignant Phenotype and Radiotherapy Sensitivity in Glioma With Different IDH1 Genotypes. Tao Y, Shi Z, Liang X, Zheng Y, Dai L, Li X, Li Z, Liang W, Bai G, Li H, Lyu Y, Li J, Zhang T, Hu W, Zhou S, Shan Q, Fu X, Wang X. Mol Carcinog. 2025 Apr;64(4):652-667. doi: 10.1002/mc.23876. Epub 2025 Jan 9. PubMed |
| DCAF13-mediated K63-linked ubiquitination of RNA polymerase I promotes uncontrolled proliferation in Breast Cancer. Yang ZZ, Yang B, Yan H, Ma X, Tian B, Zheng B, Chen YX, Dong YM, Deng J, Zhan Z, Shi Y, Zhang JY, Lu D, He JH, Zhang Y, Hu K, Zhu S, Zhou K, Zhang YC, Zheng Y, Yin D, Liao JY. Nat Commun. 2025 Jan 9;16(1):557. doi: 10.1038/s41467-025-55851-9. PubMed |
| MDM2 functions as a timer reporting the length of mitosis. Fulcher LJ, Sobajima T, Batley C, Gibbs-Seymour I, Barr FA. Nat Cell Biol. 2025 Feb;27(2):262-272. doi: 10.1038/s41556-024-01592-8. Epub 2025 Jan 9. PubMed |
| Identification of a distal enhancer of Ucp1 essential for thermogenesis and mitochondrial function in brown fat. Su D, Jiang T, Song Y, Li D, Zhan S, Zhong T, Guo J, Li L, Zhang H, Wang L. Commun Biol. 2025 Jan 9;8(1):31. doi: 10.1038/s42003-025-07468-3. PubMed |
| Mesenchymal stromal cells promote the formation of lung cancer organoids via Kindlin-2. Sui Z, Wu X, Wang J, Tan S, Zhao C, Yu Z, Wu C, Wang X, Guo L. Stem Cell Res Ther. 2025 Jan 9;16(1):7. doi: 10.1186/s13287-024-04128-x. PubMed |
| Nuclear N-WASP Induces Actin Polymerization in the Nucleus with Cortactin as an Essential Factor. Jiang X, Mohapatra P, Rossing M, Zheng W, Zbodakova O, Thatte JV, Sorensen CS, Le Phan TH, Brakebusch C. Cells. 2025 Jan 6;14(1):59. doi: 10.3390/cells14010059. PubMed |
| The adaptor protein Miro1 modulates horizontal transfer of mitochondria in mouse melanoma models. Novak J, Nahacka Z, Oliveira GL, Brisudova P, Dubisova M, Dvorakova S, Miklovicova S, Dalecka M, Puttrich V, Grycova L, Magalhaes-Novais S, Correia CM, Levoux J, Stepanek L, Prochazka J, Svec D, Reguera DP, Lopez-Domenech G, Zobalova R, Sedlacek R, Terp MG, Gammage PA, Lansky Z, Kittler J, Oliveira PJ, Ditzel HJ, Berridge MV, Rodriguez AM, Boukalova S, Rohlena J, Neuzil J. Cell Rep. 2025 Jan 28;44(1):115154. doi: 10.1016/j.celrep.2024.115154. Epub 2025 Jan 9. PubMed |
| Flap endonuclease 1 repairs DNA-protein cross-links via ADP-ribosylation-dependent mechanisms. Sun Y, Jenkins LM, El Touny LH, Zhu L, Yang X, Jo U, Escobedo L, Maity TK, Saha LK, Uribe I, Saha S, Takeda S, Leung AKL, Cheng K, Pommier Y. Sci Adv. 2025 Jan 10;11(2):eads2919. doi: 10.1126/sciadv.ads2919. Epub 2025 Jan 10. PubMed |
| Molecular basis for the stepwise and faithful maturation of the 20S proteasome. Han Y, Han Q, Tang Q, Zhang Y, Liu K. Sci Adv. 2025 Jan 10;11(2):eadr7943. doi: 10.1126/sciadv.adr7943. Epub 2025 Jan 10. PubMed |
| SLC35A2 gene product modulates paramyxovirus fusion events during infection. Yang Y, Wang Y, Campbell DE, Lee HW, Beatty W, Wang L, Baldridge M, Lopez CB. PLoS Pathog. 2025 Jan 10;21(1):e1012531. doi: 10.1371/journal.ppat.1012531. eCollection 2025 Jan. PubMed |
| In-depth inference of transcriptional regulatory networks reveals NPM1 as a therapeutic ribosomal regulator in MYC-amplified medulloblastoma. Chen T, Chen H, Xia M, Liao Y, Li H, Dong X, Lin Y, Zhou W. NPJ Precis Oncol. 2025 Jan 10;9(1):10. doi: 10.1038/s41698-024-00792-7. PubMed |
| SRC enhanced cisplatin resistance in bladder cancer by reprogramming glycolysis and pentose phosphate pathway. Gong Y, Gao D, Shi Y, Fan G, Yu X, Yang E, Cheng H, Tian J, Ding H, Liu S, Fu S, Tao Y, Shui Y, Cheng L, Li L, Wang Z. Commun Biol. 2025 Jan 10;8(1):36. doi: 10.1038/s42003-024-07284-1. PubMed |
| Pharmacological or genetic inhibition of LTCC promotes cardiomyocyte proliferation through inhibition of calcineurin activity. Devilee LAC, Salama ABM, Miller JM, Reid JD, Ou Q, Baraka NM, Abou Farraj K, Jamal M, Nong Y, Rosengart TK, Andres D, Satin J, Mohamed TMA, Hudson JE, Abouleisa RRE. NPJ Regen Med. 2025 Jan 11;10(1):1. doi: 10.1038/s41536-025-00389-z. PubMed |
| NVP-2, in combination with Orlistat, represents a promising therapeutic strategy for acute myeloid leukemia. Zhu Q, Cheng J, Gao Y, Zhang Z, Pan J, Su X, Fei D, Cai L, Yu J, Chen Y, Jiao W, Wu D, Li X, Xiao P. Cancer Biol Ther. 2025 Dec;26(1):2450859. doi: 10.1080/15384047.2025.2450859. Epub 2025 Jan 12. PubMed |
| Molecular basis for shifted receptor recognition by an encephalitic arbovirus. Fan X, Li W, Oros J, Plung JS, Plante JA, Basu H, Nagappan-Chettiar S, Boeckers JM, Tjang LV, Mann CJ, Brusic V, Buck TK, Varnum H, Yang P, Malcolm LM, Choi SY, de Souza WM, Chiu IM, Umemori H, Weaver SC, Plante KS, Abraham J. bioRxiv [Preprint]. 2025 Jan 2:2025.01.01.631009. doi: 10.1101/2025.01.01.631009. PubMed |
| Oncogenic role of RARG rearrangements in acute myeloid leukemia resembling acute promyelocytic leukemia. Wang F, Zhao L, Tan Y, Cen X, Gao H, Jiang H, Liu Y, Li Y, Zhang T, Zhao C, Shi T, Xu G, Wang C, Hu J, Li X, Qin YZ, Wang K, Zhu HH, Li K. Nat Commun. 2025 Jan 13;16(1):617. doi: 10.1038/s41467-024-55047-7. PubMed |
| Enhanced kinase translocation reporters for simultaneous real-time measurement of PKA, ERK, and calcium. Tsai SJ, Gong Y, Dabbs A, Zahra F, Xu J, Geske A, Caterina MJ, Gould SJ. J Biol Chem. 2025 Mar;301(3):108183. doi: 10.1016/j.jbc.2025.108183. Epub 2025 Jan 13. PubMed |
| Transcription factor EB (TFEB) activity increases resistance of TNBC stem cells to metabolic stress. Soleimani M, Duchow M, Goyal R, Somma A, Kaoud TS, Dalby KN, Kowalski J, Eckhardt SG, Van Den Berg C. Life Sci Alliance. 2025 Jan 15;8(3):e202302259. doi: 10.26508/lsa.202302259. Print 2025 Mar. PubMed |
| Herpesviruses mimic zygotic genome activation to promote viral replication. Neugebauer E, Walter S, Tan J, Drayman N, Franke V, van Gent M, Pennisi S, Veratti P, Stein KS, Welker I, Tay S, Verjans GMGM, Timmers HTM, Akalin A, Landthaler M, Ensser A, Wyler E, Full F. Nat Commun. 2025 Jan 16;16(1):710. doi: 10.1038/s41467-025-55928-5. PubMed |
| Massively parallel characterization of transcriptional regulatory elements. Agarwal V, Inoue F, Schubach M, Penzar D, Martin BK, Dash PM, Keukeleire P, Zhang Z, Sohota A, Zhao J, Georgakopoulos-Soares I, Noble WS, Yardimci GG, Kulakovskiy IV, Kircher M, Shendure J, Ahituv N. Nature. 2025 Mar;639(8054):411-420. doi: 10.1038/s41586-024-08430-9. Epub 2025 Jan 15. PubMed |
| A novel human fetal lung-derived alveolar organoid model reveals mechanisms of surfactant protein C maturation relevant to interstitial lung disease. Lim K, Rutherford EN, Delpiano L, He P, Lin W, Sun D, Van den Boomen DJH, Edgar JR, Bang JH, Predeus A, Teichmann SA, Marioni JC, Matesic LE, Lee JH, Lehner PJ, Marciniak SJ, Rawlins EL, Dickens JA. EMBO J. 2025 Feb;44(3):639-664. doi: 10.1038/s44318-024-00328-6. Epub 2025 Jan 15. PubMed |
| ALKBH5 suppresses gastric cancer tumorigenesis and metastasis by inhibiting the translation of uncapped WRAP53 RNA isoforms in an m6A-dependent manner. Zheng Z, Lin F, Zhao B, Chen G, Wei C, Chen X, Nie R, Zhang R, Zhao Z, Zhou Z, Li Y, Dai W, Lin Y, Chen Y. Mol Cancer. 2025 Jan 15;24(1):19. doi: 10.1186/s12943-024-02223-4. PubMed |
| Identification of novel KRAS(G12D) neoantigen specific TCRs and a strategy to eliminate off-target recognition. Han X, Han X, Hao Y, Wang B, Li L, Chen S, Zou L, Huang J, Chen T, Wang W, Liu S, Jin A, Shen M. J Transl Med. 2025 Jan 17;23(1):78. doi: 10.1186/s12967-025-06094-1. PubMed |
| Kaposi's sarcoma-associated herpesvirus (KSHV) gB dictates a low-pH endocytotic entry pathway as revealed by a dual-fluorescent virus system and a rhesus monkey rhadinovirus expressing KSHV gB. Liu S, Schlagowski S, Grosskopf AK, Khizanishvili N, Yang X, Wong SW, Guzman EM, Backovic M, Scribano S, Cordsmeier A, Ensser A, Hahn AS. PLoS Pathog. 2025 Jan 16;21(1):e1012846. doi: 10.1371/journal.ppat.1012846. eCollection 2025 Jan. PubMed |
| Protocol for evaluating humoral immune responses in mice following SARS-CoV-2 vaccination. Zhang Y, Li S, Yu J. STAR Protoc. 2025 Mar 21;6(1):103548. doi: 10.1016/j.xpro.2024.103548. Epub 2025 Jan 15. PubMed |
| Nb-FAR-1: A key developmental protein affects lipid droplet accumulation and cuticle formation in Nippostrongylus brasiliensis. Qi W, Shen F, Wang C, Wen J, Pan X, Zhao Z, Xiao L, Feng Y, Yuan D. PLoS Negl Trop Dis. 2025 Jan 17;19(1):e0012769. doi: 10.1371/journal.pntd.0012769. eCollection 2025 Jan. PubMed |
| Large Donor CRISPR for Whole-Coding Sequence Replacement of Cell Adhesion Molecule LRRTM2. Pollitt SL, Levy AD, Anderson MC, Blanpied TA. J Neurosci. 2025 Feb 12;45(7):e1461242024. doi: 10.1523/JNEUROSCI.1461-24.2024. PubMed |
| Human ACE2 transgenic pigs are susceptible to SARS-CoV-2 and develop COVID-19-like disease. Chau LF, Lillico S, Opriessnig T, Blake R, Tardy L, Lee CH, Maxwell S, Warren C, Thornton E, Mclaughlin CL, McLachlan G, Tait-Burkard C, Fletcher S, Anderson S, Brown S, Gibbard L, Tzelos T, MacMillan-Christensen D, Baillie JK, Dorward DA, Griffiths DJ, Grey F. Nat Commun. 2025 Jan 17;16(1):766. doi: 10.1038/s41467-024-54615-1. PubMed |
| Decoding the m(6)A epitranscriptomic landscape for biotechnological applications using a direct RNA sequencing approach. Liu C, Liang H, Wan AH, Xiao M, Sun L, Yu Y, Yan S, Deng Y, Liu R, Fang J, Wang Z, He W, Wan G. Nat Commun. 2025 Jan 18;16(1):798. doi: 10.1038/s41467-025-56173-6. PubMed |
| Enhancer regulatory networks globally connect non-coding breast cancer loci to cancer genes. Wang Y, Armendariz DA, Wang L, Zhao H, Xie S, Hon GC. Genome Biol. 2025 Jan 17;26(1):10. doi: 10.1186/s13059-025-03474-0. PubMed |
| Construction of a Vero cell line expression human KREMEN1 for the development of CVA6 vaccines. Zhang D, Zou Y, Wu J, Xu L, Ke Z, Wu Y, Zhou Z, Fang M, Chen L, Xu H, Chu J, Xia N, Zhu R, Cheng T. Virol J. 2025 Jan 17;22(1):12. doi: 10.1186/s12985-024-02618-1. PubMed |
| 19S proteasome loss causes monopolar spindles through ubiquitin-independent KIF11 degradation. Marescal O, Cheeseman IM. bioRxiv [Preprint]. 2025 Jan 9:2025.01.08.632038. doi: 10.1101/2025.01.08.632038. PubMed |
| BRAT1 - a new therapeutic target for glioblastoma. Haydo A, Schmidt J, Crider A, Kogler T, Ertl J, Hehlgans S, Hoffmann ME, Rathore R, Gullulu O, Wang Y, Zhang X, Herold-Mende C, Pampaloni F, Tegeder I, Dikic I, Dai M, Rodel F, Kogel D, Linder B. Cell Mol Life Sci. 2025 Jan 21;82(1):52. doi: 10.1007/s00018-024-05553-0. PubMed |
| Comprehensive analysis of H3K27me3 LOCKs under different DNA methylation contexts reveal epigenetic redistribution in tumorigenesis. Liang Y, Liu M, Liu B, Ziman B, Peng G, Mao Q, Wang X, Jiang L, Lin DC, Zheng Y. Epigenetics Chromatin. 2025 Jan 20;18(1):6. doi: 10.1186/s13072-025-00570-0. PubMed |
| Loss of SMAD1 in acute myeloid leukemia with KMT2A::AFF1 and KMT2A::MLLT3 fusion genes. Dietsche L, Stirm K, Lysenko V, Schneidawind C, Tzankov A, Muller A, Theocharides APA. Front Oncol. 2025 Jan 6;14:1481713. doi: 10.3389/fonc.2024.1481713. eCollection 2024. PubMed |
| High CDC20 levels increase sensitivity of cancer cells to MPS1 inhibitors. Zheng S, Raz L, Zhou L, Cohen-Sharir Y, Tian R, Ippolito MR, Gianotti S, Saad R, Wardenaar R, Broekhuis M, Suarez Peredo Rodriguez M, Wobben S, van den Brink A, Bakker P, Santaguida S, Foijer F, Ben-David U. EMBO Rep. 2025 Feb;26(4):1036-1061. doi: 10.1038/s44319-024-00363-8. Epub 2025 Jan 21. PubMed |
| Co-isolation of human donor eye cells and development of oncogene-mutated melanocytes to study uveal melanoma. Chen Y, Jin E, Abdouh M, Bonneil E, Jimenez Cruz DA, Tsering T, Zhou Q, Fuentes-Rodriguez A, Bartolomucci A, Goyeneche A, Landreville S, Burnier MN, Burnier JV. BMC Biol. 2025 Jan 21;23(1):16. doi: 10.1186/s12915-025-02118-w. PubMed |
| Ergothioneine improves healthspan of aged animals by enhancing cGPDH activity through CSE-dependent persulfidation. Petrovic D, Slade L, Paikopoulos Y, D'Andrea D, Savic N, Stancic A, Miljkovic JL, Vignane T, Drekolia MK, Mladenovic D, Sutulovic N, Refeyton A, Kolakovic M, Jovanovic VM, Zivanovic J, Miler M, Vellecco V, Brancaleone V, Bucci M, Casey AM, Yu C, Kasarla SS, Smith KW, Kalfe-Yildiz A, Stenzel M, Miranda-Vizuete A, Hergenroder R, Phapale P, Stanojlovic O, Ivanovic-Burmazovic I, Vlaski-Lafarge M, Bibli SI, Murphy MP, Otasevic V, Filipovic MR. Cell Metab. 2025 Feb 4;37(2):542-556.e14. doi: 10.1016/j.cmet.2024.12.008. Epub 2025 Jan 21. PubMed |
| Rapid and scalable personalized ASO screening in patient-derived organoids. Means JC, Martinez-Bengochea AL, Louiselle DA, Nemechek JM, Perry JM, Farrow EG, Pastinen T, Younger ST. Nature. 2025 Feb;638(8049):237-243. doi: 10.1038/s41586-024-08462-1. Epub 2025 Jan 22. PubMed |
| A novel peptide encoded by circSRCAP confers resistance to enzalutamide by inhibiting the ubiquitin-dependent degradation of AR-V7 in castration-resistant prostate cancer. Meng X, Wu Q, Cao C, Yang W, Chu S, Guo H, Qi S, Bai J. J Transl Med. 2025 Jan 23;23(1):108. doi: 10.1186/s12967-025-06115-z. PubMed |
| Multidimensional, integrative profiling identifies BCL2L1 methylation as a predictor of MCL1 dependency in pediatric malignancies. Adjumain S, Daniel P, Sun CX, Bradshaw G, Chew NJ, Tsui V, Lee H, Loi M, Zhukova N, Habarakada D, Yoel A, Vaghjiani VG, Game S, Ludlow LE, Neeman N, Sweet-Cordero EA, Eisenstat DD, Cain JE, Firestein R. JCI Insight. 2025 Jan 23;10(2):e184601. doi: 10.1172/jci.insight.184601. PubMed |
| MSC-sEVs exacerbate senescence by transferring bisecting GlcNAcylated GPNMB. Ma Y, Zhao C, Feng J, Gou J, Kang E, Guan F, Wu Q, Li X. Stem Cell Res Ther. 2025 Jan 23;16(1):23. doi: 10.1186/s13287-025-04140-9. PubMed |
| Subtype-specific human endogenous retrovirus K102 envelope protein is a novel serum immunosuppressive biomarker of cancer. Gong Q, Xu R. Front Immunol. 2025 Jan 9;15:1533740. doi: 10.3389/fimmu.2024.1533740. eCollection 2024. PubMed |
| The TLR7/9 adaptors TASL and TASL2 mediate IRF5-dependent antiviral responses and autoimmunity in mouse. Drobek A, Bernaleau L, Delacretaz M, Calderon Copete S, Royer-Chardon C, Longepierre M, Monguio-Tortajada M, Korzeniowski J, Rotman S, Marquis J, Rebsamen M. Nat Commun. 2025 Jan 24;16(1):967. doi: 10.1038/s41467-024-55692-y. PubMed |
| SLC25A38 is required for mitochondrial pyridoxal 5'-phosphate (PLP) accumulation. Pena IA, Shi JS, Chang SM, Yang J, Block S, Adelmann CH, Keys HR, Ge P, Bathla S, Witham IH, Sienski G, Nairn AC, Sabatini DM, Lewis CA, Kory N, Vander Heiden MG, Heiman M. Nat Commun. 2025 Jan 24;16(1):978. doi: 10.1038/s41467-025-56130-3. PubMed |
| miR-224 activates cancer-associated fibroblasts to enhance lung cancer cell migration and invasion by targeting Akirin1. Oh S, Lee S, Cheon I, Ahn YH. Sci Rep. 2025 Jan 24;15(1):3050. doi: 10.1038/s41598-024-82189-x. PubMed |
| Proteomic profiling identifies upregulation of aurora kinases causing resistance to taxane-type chemotherapy in triple negative breast cancer. Ning B, Liu C, Kucukdagli AC, Zhang J, Jing H, Zhou Z, Zhang Y, Dong Y, Chen Y, Guo H, Xu J. Sci Rep. 2025 Jan 25;15(1):3211. doi: 10.1038/s41598-025-87315-x. PubMed |
| Atovaquone and selinexor as a novel combination treatment option in acute myeloid leukemia. Weiss S, Zdarsky B, Witalisz-Siepracka A, Edtmayer S, Holzer A, Heindl K, Casanova E, Podar K, Stoiber D. Cancer Lett. 2025 Mar 31;613:217501. doi: 10.1016/j.canlet.2025.217501. Epub 2025 Jan 24. PubMed |
| gamma-secretase facilitates retromer-mediated retrograde transport. Takeo Y, Crite M, Mehmood K, DiMaio D. J Cell Sci. 2025 Feb 15;138(4):JCS263538. doi: 10.1242/jcs.263538. Epub 2025 Feb 20. PubMed |
| Harnessing Extracellular Vesicles for Stabilized and Functional IL-10 Delivery in Macrophage Immunomodulation. Saleh NA, Gagea MA, Vitija X, Janovic T, Schmidt JC, Deng CX, Kanada M. bioRxiv [Preprint]. 2025 Jan 18:2025.01.14.633016. doi: 10.1101/2025.01.14.633016. PubMed |
| A mitochondria-to-nucleus regulation mediated by the nuclear-translocated mitochondrial lncRNAs. Li J, Bai R, Zhou Y, Song X, Li L. PLoS Genet. 2025 Jan 27;21(1):e1011580. doi: 10.1371/journal.pgen.1011580. eCollection 2025 Jan. PubMed |
| A compendium of Amplification-Related Gain Of Sensitivity genes in human cancer. Rendo V, Schubert M, Khuu N, Suarez Peredo Rodriguez MF, Whyte D, Ling X, van den Brink A, Huang K, Swift M, He Y, Zerbib J, Smith R, Raaijmakers J, Bandopadhayay P, Guenther LM, Hwang JH, Iniguez A, Moody S, Seo JH, Stover EH, Garraway L, Hahn WC, Stegmaier K, Medema RH, Chowdhury D, Colome-Tatche M, Ben-David U, Beroukhim R, Foijer F. Nat Commun. 2025 Jan 27;16(1):1077. doi: 10.1038/s41467-025-56301-2. PubMed |
| A genome-wide atlas of human cell morphology. Ramezani M, Weisbart E, Bauman J, Singh A, Yong J, Lozada M, Way GP, Kavari SL, Diaz C, Leardini E, Jetley G, Pagnotta J, Haghighi M, Batista TM, Perez-Schindler J, Claussnitzer M, Singh S, Cimini BA, Blainey PC, Carpenter AE, Jan CH, Neal JT. Nat Methods. 2025 Mar;22(3):621-633. doi: 10.1038/s41592-024-02537-7. Epub 2025 Jan 27. PubMed |
| CRM1 regulates androgen receptor stability and impacts DNA repair pathways in prostate cancer, independent of the androgen receptor. Kumar R, Mendonca J, Shetty A, Yang Y, Owoyemi O, Wilson L, Boyapati K, Topiwala D, Thomas N, Nguyen H, Luo J, Paller CJ, Denmeade SR, Carducci MA, Kachhap SK. FASEB J. 2025 Jan 31;39(2):e70342. doi: 10.1096/fj.202400490R. PubMed |
| Inhibition of triglyceride metabolism-associated enhancers alters lipid deposition during adipocyte differentiation. Zeng S, Li Z, Li X, Du Q, Zhang Y, Zhong Z, Wang H, Zhang S, Li P, Li H, Chen L, Jiang A, Shang P, Li M, Long K. FASEB J. 2025 Jan 31;39(2):e70347. doi: 10.1096/fj.202401137R. PubMed |
| Deciphering the interplay between SETD2 mediated H3K36me3 and RNA N6-methyladenosine in clear cell renal cell carcinoma (ccRCC). Shaikh S, Zhao X, Wagner RT, Pan X, Hlady RA, Wang L, Ho TH, Robertson KD. Epigenetics. 2025 Dec;20(1):2456418. doi: 10.1080/15592294.2025.2456418. Epub 2025 Jan 28. PubMed |
Cell-free assays reveal that the HIV-1 capsid protects reverse transcripts from cGAS immune sensing.
Scott TM, Arnold LM, Powers JA, McCann DA, Rowe AB, Christensen DE, Pereira MJ, Zhou W, Torrez RM, Iwasa JH, Kranzusch PJ, Sundquist WI, Johnson JS.
PLoS Pathog. 2025 Jan 28;21(1):e1012206. doi: 10.1371/journal.ppat.1012206.
PubMed
Associated Plasmids |
| A study on the production of extracellular vesicles derived from novel immortalized human placental mesenchymal stromal cells. Tong Y, Sun J, Jiang X, Jia X, Xiao H, Wang H, Yang G. Sci Rep. 2025 Jan 28;15(1):3568. doi: 10.1038/s41598-025-87371-3. PubMed |
| TDP-43 nuclear retention is antagonized by hypo-phosphorylation of its C-terminus in the cytoplasm. Rabhi C, Babault N, Martin C, Desforges B, Maucuer A, Joshi V, Pankivskyi S, Feng Y, Bollot G, Rattenbach R, Pastre D, Bouhss A. Commun Biol. 2025 Jan 28;8(1):136. doi: 10.1038/s42003-025-07456-7. PubMed |
| c-JUN: a chromatin repressor that limits mesoderm differentiation in human pluripotent stem cells. Zhang R, Li G, Zhang Q, Wang Z, Xiang D, Zhang X, Chen J, Hutchins AP, Qin D, Su H, Pei D, Li D. Nucleic Acids Res. 2025 Jan 24;53(3):gkaf001. doi: 10.1093/nar/gkaf001. PubMed |
| The Histone Demethylase LSD1/ZNF217/CoREST Complex is a Major Restriction Factor of Epstein-Barr Virus Lytic Reactivation. Liao Y, Yan J, Kong I, Li Z, Ding W, Clark S, Giulino-Roth L, Gewurz BE. Res Sq [Preprint]. 2025 Jan 13:rs.3.rs-5649616. doi: 10.21203/rs.3.rs-5649616/v1. PubMed |
| Sodium valproate enhances efficacy of NKG2D CAR-T cells against glioblastoma. Liu J, Dai K, Saliu MA, Salisu MD, Gan J, Afolabi LO, Yan D, Zhang G, Liu M, Wan X. Front Immunol. 2025 Jan 14;15:1519777. doi: 10.3389/fimmu.2024.1519777. eCollection 2024. PubMed |
| Establishment of a human ovarian endometrioid carcinoma cell line by constitutive expression of cyclin-dependent kinase 4, cyclin D1 and telomerase reverse transcriptase. Hoshino H, Akama TO, Inoue D, Moritani S, Shigeto S, Matsuda K, Yoshida H, Yonemoto N, Fukushima M, Yoshida Y, Kobayashi M. Hum Cell. 2025 Jan 29;38(2):47. doi: 10.1007/s13577-025-01176-0. PubMed |
| Spherical harmonics texture extraction for versatile analysis of biological objects. Gros O, Passmore JB, Borst NO, Kutra D, Nijenhuis W, Fuqua T, Kapitein LC, Crocker JM, Kreshuk A, Kohler S. PLoS Comput Biol. 2025 Jan 29;21(1):e1012349. doi: 10.1371/journal.pcbi.1012349. eCollection 2025 Jan. PubMed |
| Targeting pancreatic cancer glutamine dependency confers vulnerability to GPX4-dependent ferroptosis. Shen X, Chen Y, Tang Y, Lu P, Liu M, Mao T, Weng Y, Yu F, Liu Y, Tang Y, Wang L, Niu N, Xue J. Cell Rep Med. 2025 Feb 18;6(2):101928. doi: 10.1016/j.xcrm.2025.101928. Epub 2025 Jan 28. PubMed |
| Bat genomes illuminate adaptations to viral tolerance and disease resistance. Morales AE, Dong Y, Brown T, Baid K, Kontopoulos D-, Gonzalez V, Huang Z, Ahmed AW, Bhuinya A, Hilgers L, Winkler S, Hughes G, Li X, Lu P, Yang Y, Kirilenko BM, Devanna P, Lama TM, Nissan Y, Pippel M, Davalos LM, Vernes SC, Puechmaille SJ, Rossiter SJ, Yovel Y, Prescott JB, Kurth A, Ray DA, Lim BK, Myers E, Teeling EC, Banerjee A, Irving AT, Hiller M. Nature. 2025 Feb;638(8050):449-458. doi: 10.1038/s41586-024-08471-0. Epub 2025 Jan 29. PubMed |
| G3BP1 ribonucleoprotein complexes regulate focal adhesion protein mobility and cell migration. Boraas LC, Hu M, Martino P, Thornton L, Vejnar CE, Zhen G, Zeng L, Parker DM, Cox AL, Giraldez AJ, Su X, Mayr C, Wang S, Nicoli S. Cell Rep. 2025 Feb 25;44(2):115237. doi: 10.1016/j.celrep.2025.115237. Epub 2025 Feb 1. PubMed |
| Pharmacological ascorbate combined with rucosopasem selectively radio-chemo-sensitizes NSCLC via generation of H(2)O(2). Pulliam CF, Fath MA, Sho S, Johnson ST, Wagner BA, Singhania M, Kalen AL, Bayanbold K, Solst SR, Allen BG, George BN, Caster JM, Buettner GR, Riley DP, Keene JL, Beardsley RA, Spitz DR. Redox Biol. 2025 Mar;80:103505. doi: 10.1016/j.redox.2025.103505. Epub 2025 Jan 23. PubMed |
| EZH2 serves as a viable therapeutic target for myeloma-induced osteolytic bone destruction. Liu R, Li Z, Chen R, Fang Z, Liu Z, Liu H. Nat Commun. 2025 Jan 31;16(1):1206. doi: 10.1038/s41467-025-56506-5. PubMed |
| Targeting ABCD1-ACOX1-MET/IGF1R axis suppresses multiple myeloma. Han Z, Yan Z, Ma Z, Wang Y, Beus M, Lu J, Weidenhammer LB, Lakhani K, Lee J, Civils JD, Furdui CM, Liu L, Wu J, Kang Y, Bieberich E, Boise LH, Nikiforov MA. Leukemia. 2025 Mar;39(3):720-733. doi: 10.1038/s41375-025-02522-9. Epub 2025 Jan 30. PubMed |
| A novel mannan-specific chimeric antigen receptor M-CAR redirects T cells to interact with Candida spp. hyphae and Rhizopus oryzae spores. Guimaraes JG, de Campos GY, Machado MP, Oliveira Brito PKM, Dos Reis TF, Goldman GH, Bonini Palma PV, de Campos Fraga-Silva TF, Cavallin DCU, Venturini J, da Silva TA. Bioengineered. 2025 Dec;16(1):2458786. doi: 10.1080/21655979.2025.2458786. Epub 2025 Feb 1. PubMed |
| Vaccine-induced T cell receptor T cell therapy targeting a glioblastoma stemness antigen. Chih YC, Dietsch AC, Koopmann P, Ma X, Agardy DA, Zhao B, De Roia A, Kourtesakis A, Kilian M, Kramer C, Suwala AK, Stenzinger M, Boenig H, Blum A, Pienkowski VM, Aman K, Becker JP, Feldmann H, Bunse T, Harbottle R, Riemer AB, Liu HK, Etminan N, Sahm F, Ratliff M, Wick W, Platten M, Green EW, Bunse L. Nat Commun. 2025 Feb 1;16(1):1262. doi: 10.1038/s41467-025-56547-w. PubMed |
| Effective in vivo binding energy landscape illustrates kinetic stability of RBPJ-DNA binding. Huynh D, Hoffmeister P, Friedrich T, Zhang K, Bartkuhn M, Ferrante F, Giaimo BD, Kovall RA, Borggrefe T, Oswald F, Gebhardt JCM. Nat Commun. 2025 Feb 1;16(1):1259. doi: 10.1038/s41467-025-56515-4. PubMed |
| Genome-scale spatial mapping of the Hodgkin lymphoma microenvironment identifies tumor cell survival factors. Shanmugam V, Tokcan N, Chafamo D, Sullivan S, Borji M, Martin H, Newton G, Nadaf N, Hanbury S, Barrera I, Cable D, Weir J, Ashenberg O, Pinkus G, Rodig S, Uhler C, Macosko E, Shipp M, Louissaint A Jr, Chen F, Golub T. bioRxiv [Preprint]. 2025 Jan 25:2025.01.24.631210. doi: 10.1101/2025.01.24.631210. PubMed |
| Signal peptide-independent secretion of keratin-19 by pancreatic cancer cells. Moresco P, Kastan JP, Yang JI, Prabakar R, Minicozzi F, Adams DW, Cifani P, Tuveson DA, Fearon DT. bioRxiv [Preprint]. 2025 Jan 20:2025.01.18.633717. doi: 10.1101/2025.01.18.633717. PubMed |
| Protein phosphatase EYA1 regulates the dephosphorylation and turnover of BCL2L12 to promote glioma development. Wei T, Lin R, Lu Y, Jin DY, Zhang J, Sham MH. Int J Biol Sci. 2025 Jan 13;21(3):1081-1096. doi: 10.7150/ijbs.99619. eCollection 2025. PubMed |
| Comprehensive Pan-Cancer Analysis of RAC1 Decoding the Impact on Cancer Prognosis and B cell immune Regulation. Shao Z, Ren H, Wang X, Zhang Q, Xue J, Chi Y, Xiu B, Wu J. Int J Med Sci. 2025 Jan 13;22(3):662-679. doi: 10.7150/ijms.104488. eCollection 2025. PubMed |
| Skeletal muscle stem cells modulate niche function in Duchenne muscular dystrophy mouse through YY1-CCL5 axis. Li Y, Li C, Sun Q, Liu X, Chen F, Cheung Y, Zhao Y, Xie T, Chazaud B, Sun H, Wang H. Nat Commun. 2025 Feb 3;16(1):1324. doi: 10.1038/s41467-025-56474-w. PubMed |
| Host factor PLAC8 is required for pancreas infection by SARS-CoV-2. Ibarguen-Gonzalez L, Heller S, Lopez-Garcia D, Dietenberger H, Barth TF, Gallego P, Fernandez-Cadenas I, Alzate-Pinol S, Crespi C, Mena-Guerrero JA, Cisneros-Barroso E, Ugalde AP, Bretones G, Steenblock C, Kleger A, DeDiego ML, Barcelo C. Commun Med (Lond). 2025 Feb 3;5(1):34. doi: 10.1038/s43856-025-00745-6. PubMed |
| Development and characterization of a double-fluorescent HIV-1 reporter cellular model to tackle the Rev-dependent export pathway. Wadas J, Ali H, Osiecka A, Dorman A, Pyrc K, Kula-Pacurar A. Microbiol Spectr. 2025 Mar 4;13(3):e0190324. doi: 10.1128/spectrum.01903-24. Epub 2025 Feb 4. PubMed |
| Molecular control of PDPNhi macrophage subset induction by ADAP as a host defense in sepsis. Zhang P, Wang X, Yang X, Liu H. JCI Insight. 2025 Feb 4;10(6):e186456. doi: 10.1172/jci.insight.186456. PubMed |
| Multi-locus CRISPRi targeting with a single truncated guide RNA. Moore MM, Wekhande S, Issner R, Collins A, Cruz AJ, Liu YV, Javed N, Casani-Galdon S, Buenrostro JD, Epstein CB, Mattei E, Doench JG, Bernstein BE, Shoresh N, Najm FJ. Nat Commun. 2025 Feb 4;16(1):1357. doi: 10.1038/s41467-025-56144-x. PubMed |
| N-Cadherin based adhesion and Rac1 activity regulate tension polarization in the actin cortex. Moazzeni S, Kyker-Snowman K, Cohen RI, Wang H, Li R, Shreiber DI, Zahn JD, Shi Z, Lin H. Sci Rep. 2025 Feb 4;15(1):4296. doi: 10.1038/s41598-025-88537-9. PubMed |
| Brd7 loss reawakens dormant metastasis initiating cells in lung by forging an immunosuppressive niche. Mondal J, Zhang J, Qing F, Li S, Kumar D, Huse JT, Giancotti FG. Nat Commun. 2025 Feb 5;16(1):1378. doi: 10.1038/s41467-025-56347-2. PubMed |
SKI complex loss renders 9p21.3-deleted or MSI-H cancers dependent on PELO.
Borck PC, Boyle I, Jankovic K, Bick N, Foster K, Lau AC, Parker-Burns LI, Lubicki DA, Li T, Borah AA, Lofaso NJ, Das Sharma S, Chan T, Kishen RV, Adeagbo A, Raghavan S, Aquilanti E, Prensner JR, Krill-Burger JM, Golub TR, Campbell CD, Dempster JM, Chan EM, Vazquez F.
Nature. 2025 Feb 5. doi: 10.1038/s41586-024-08509-3.
PubMed
Associated Plasmids |
| SETD2 loss-of-function uniquely sensitizes cells to epigenetic targeting of NSD1-directed H3K36 methylation. Wagner RT, Hlady RA, Pan X, Wang L, Kim S, Zhao X, El Khoury LY, Shaikh S, Zhong J, Lee JH, Grembecka J, Cierpicki T, Ho TH, Robertson KD. Genome Biol. 2025 Feb 5;26(1):22. doi: 10.1186/s13059-025-03483-z. PubMed |
| Host 3' flap endonuclease Mus81 plays a critical role in trimming the terminal redundancy of hepatitis B virus relaxed circular DNA during covalently closed circular DNA formation. Zhang H, Long Q, Liu Y, Marchetti AL, Liu CD, Sun N, Guo H. PLoS Pathog. 2025 Feb 6;21(2):e1012918. doi: 10.1371/journal.ppat.1012918. eCollection 2025 Feb. PubMed |
| Methylstat sensitizes ovarian cancer cells to PARP-inhibition by targeting the histone demethylases JMJD1B/C. Schwarz FM, Klotz DM, Yang R, Brux M, Buchholz F, Harb H, Link T, Wimberger P, Theis M, Kuhlmann JD. Cancer Gene Ther. 2025 Mar;32(3):286-296. doi: 10.1038/s41417-025-00874-z. Epub 2025 Feb 6. PubMed |
| Targeted detection of endogenous LINE-1 proteins and ORF2p interactions. Nielsen MI, Wolters JC, Bringas OGR, Jiang H, Di Stefano LH, Oghbaie M, Hozeifi S, Nitert MJ, van Pijkeren A, Smit M, Ter Morsche L, Mourtzinos A, Deshpande V, Taylor MS, Chait BT, LaCava J. Mob DNA. 2025 Feb 6;16(1):3. doi: 10.1186/s13100-024-00339-4. PubMed |
| Antibody-Dependent Cellular Cytotoxicity of iPS Cell-Derived Natural Killer T Cells by Anti-GD2 mAb for Neuroblastoma. Nishimura K, Aoki T, Kobayashi M, Takami M, Ozaki K, Ogawa K, Hongxuan W, Shimizu D, Katsumi D, Yoshizawa H, Komatsu S, Takatani T, Hirahara K, Koseki H, Hishiki T, Motohashi S. Cancer Sci. 2025 Apr;116(4):884-896. doi: 10.1111/cas.70008. Epub 2025 Feb 6. PubMed |
| Genome-scale CRISPR/Cas9 screening reveals the role of PSMD4 in colibactin-mediated cell cycle arrest. Dougherty MW, Hoffmann RM, Hernandez MC, Airan Y, Gharaibeh RZ, Herzon SB, Yang Y, Jobin C. mSphere. 2025 Mar 25;10(3):e0069224. doi: 10.1128/msphere.00692-24. Epub 2025 Feb 7. PubMed |
| A synthetic chronogenetic gene circuit for programmed circadian drug delivery. Pferdehirt L, Damato AR, Lenz KL, Gonzalez-Aponte MF, Palmer D, Meng QJ, Herzog ED, Guilak F. Nat Commun. 2025 Feb 7;16(1):1457. doi: 10.1038/s41467-025-56584-5. PubMed |
| Mutations in the kinesin KIF12 promote MASH in humans and mice by disrupting lipogenic enzyme turnover. Etemad A, Tanaka Y, Wang S, Slae M, Sultan M, Elpeleg O, Hirokawa N. EMBO J. 2025 Mar;44(6):1608-1640. doi: 10.1038/s44318-025-00366-8. Epub 2025 Feb 7. PubMed |
| GNE-317 Reverses MSN-Mediated Proneural-to-Mesenchymal Transition and Suppresses Chemoradiotherapy Resistance in Glioblastoma via PI3K/mTOR. Yang YC, Jin XY, Yang LL, Xu X, Xie Y, Ai YD, Li XC, Ma YC, Xu CL, Li Q, Ge XL, Yi TL, Jiang T, Wang XG, Piao YZ, Jin X. Adv Sci (Weinh). 2025 Mar;12(12):e2412517. doi: 10.1002/advs.202412517. Epub 2025 Feb 7. PubMed |
| Combined inhibition of focal adhesion kinase and RAF/MEK elicits synergistic inhibition of melanoma growth and reduces metastases. Almazan J, Turapov T, Kircher DA, Stanley KA, Culver K, Medellin AP, Field MN, Parkman GL, Colman H, Coma S, Pachter JA, Holmen SL. Cell Rep Med. 2025 Feb 18;6(2):101943. doi: 10.1016/j.xcrm.2025.101943. Epub 2025 Feb 7. PubMed |
| FNDC5/irisin mitigates the cardiotoxic impacts of cancer chemotherapeutics by modulating ROS-dependent and -independent mechanisms. Kumar M, Sengar AS, Lye A, Kumar P, Mukherjee S, Kumar D, Das P, Chatterjee S, Stewart A, Maity B. Redox Biol. 2025 Mar;80:103527. doi: 10.1016/j.redox.2025.103527. Epub 2025 Feb 4. PubMed |
| Dual roles of exostosin glycosyltransferase 1 in Zika virus infection. Ling J, Khan A, Denkewitz M, Maccarana M, Lundkvist A, Li JP, Li J. Virulence. 2025 Dec;16(1):2458681. doi: 10.1080/21505594.2025.2458681. Epub 2025 Feb 10. PubMed |
| Generation of RNA aptamers against chikungunya virus E2 envelope protein. Goto K, Amano R, Ichinose A, Michishita A, Hamada M, Nakamura Y, Takahashi M. J Virol. 2025 Mar 18;99(3):e0209524. doi: 10.1128/jvi.02095-24. Epub 2025 Feb 10. PubMed |
| MAP1LC3C repression reduces CIITA- and HLA class II expression in non-small cell lung cancer. Barbeau LMO, Beelen NA, Savelkouls KG, Keulers TGH, Wieten L, Rouschop KMA. PLoS One. 2025 Feb 10;20(2):e0316716. doi: 10.1371/journal.pone.0316716. eCollection 2025. PubMed |
| SOCS1 Protects Acute Myeloid Leukemia against Allogeneic T Cell-Mediated Cytotoxicity. Tin E, Rutella S, Khatri I, Na Y, Yan Y, MacLean N, Vadakekolathu J, Minden MD, Schimmer AD, Lee J, Zhang L. Blood Cancer Discov. 2025 May 5;6(3):217-232. doi: 10.1158/2643-3230.BCD-24-0140. PubMed |
| Equine adult, fetal and ESC-tenocytes have differential migratory, proliferative and gene expression responses to factors upregulated in the injured tendon. Beaumont RE, Smith EJ, David C, Paterson YZ, Faull E, Guest DJ. Cells Dev. 2025 Mar;181:204003. doi: 10.1016/j.cdev.2025.204003. Epub 2025 Feb 8. PubMed |
| Multi-omics analyses reveal biological and clinical insights in recurrent stage I non-small cell lung cancer. Wang C, Li J, Chen J, Wang Z, Zhu G, Song L, Wu J, Li C, Qiu R, Chen X, Zhang L, Li W. Nat Commun. 2025 Feb 10;16(1):1477. doi: 10.1038/s41467-024-55068-2. PubMed |
| Tribbles Pseudokinase 3 Converts Sorafenib Therapy to Neutrophil-Mediated Lung Metastasis in Hepatocellular Carcinoma. Wang XY, Liao Y, Wang RQ, Lu YT, Wang YZ, Xin YQ, Kuang DM, Lao XM, Xu J, Zhou ZL, Hu K. Adv Sci (Weinh). 2025 Apr;12(13):e2413682. doi: 10.1002/advs.202413682. Epub 2025 Feb 11. PubMed |
| Integrative analysis reveals therapeutic potential of pyrvinium pamoate in Merkel cell carcinoma. Yang J, Lim JT, Santiago Raj PV, Corona MG, Chen C, Khawaja H, Pan Q, Paine-Murrieta GD, Schnellmann RG, Roe DJ, Gokhale PC, DeCaprio JA, Padi M. J Clin Invest. 2025 Feb 11;135(7):e177724. doi: 10.1172/JCI177724. PubMed |
Biomolecular condensation of human IDRs initiates endogenous transcription via intrachromosomal looping or high-density promoter localization.
Li J, Liu S, Kim S, Goell J, Drum ZA, Flores JP, Ma AJ, Mahata B, Escobar M, Raterink A, Ahn JH, Teran ER, Guerra-Resendez RS, Zhou Y, Yu B, Diehl MR, Wang GG, Gustavsson AK, Phanstiel DH, Hilton IB.
Nucleic Acids Res. 2025 Feb 8;53(4):gkaf056. doi: 10.1093/nar/gkaf056.
PubMed
Associated Plasmids |
| Pooled screening for CAR function identifies novel IL-13Ralpha2-targeted CARs for treatment of glioblastoma. Gordon KS, Perez CR, Garmilla A, Lam MSY, Aw JJY, Datta A, Lauffenburger DA, Pavesi A, Birnbaum ME. J Immunother Cancer. 2025 Feb 11;13(2):e009574. doi: 10.1136/jitc-2024-009574. PubMed |
Genomic mediators of acquired resistance to immunotherapy in metastatic melanoma.
Schiantarelli J, Benamar M, Park J, Sax HE, Oliveira G, Bosma-Moody A, Campbell KM, Liu D, Johnson DB, Rodig S, Wu CJ, Hodi FS, Ribas A, Van Allen E, Haq R.
Cancer Cell. 2025 Feb 10;43(2):308-316.e6. doi: 10.1016/j.ccell.2025.01.009.
PubMed
Associated Plasmids |
| Aberrant expression of GTPase-activating protein ARAP1 triggers circular dorsal ruffles associated with malignancy in hepatocellular carcinoma Hep3B cells. Sun X, Li Y, He Y, Cheng L, Wang L, Wei J, Chen J, Du L, Shen Z, Xie Y, Midgley AC, Jiang W, Yoshida S. Cell Commun Signal. 2025 Feb 11;23(1):75. doi: 10.1186/s12964-025-02084-4. PubMed |
| Single-cell and spatial-resolved profiling reveals cancer-associated fibroblast heterogeneity in colorectal cancer metabolic subtypes. Wang Y, Qiu X, Li Q, Qin J, Ye L, Zhang X, Huang X, Wen X, Wang Z, He W, Di Y, Zhou Q. J Transl Med. 2025 Feb 11;23(1):175. doi: 10.1186/s12967-025-06103-3. PubMed |
| Dysfunctional mechanotransduction regulates the progression of PIK3CA-driven vascular malformations. Aw WY, Sawhney A, Rathod M, Whitworth CP, Doherty EL, Madden E, Lu J, Westphal K, Stack R, Polacheck WJ. APL Bioeng. 2025 Feb 5;9(1):016106. doi: 10.1063/5.0234507. eCollection 2025 Mar. PubMed |
| Protocol for the purification and analysis of nuclear UFMylated proteins. Panichnantakul P, Oeffinger M. STAR Protoc. 2025 Mar 21;6(1):103634. doi: 10.1016/j.xpro.2025.103634. Epub 2025 Feb 10. PubMed |
| Fungal Als proteins hijack host death effector domains to promote inflammasome signaling. Zhou T, Solis NV, Marshall M, Yao Q, Pearlman E, Filler SG, Liu H. Nat Commun. 2025 Feb 12;16(1):1562. doi: 10.1038/s41467-025-56657-5. PubMed |
| Intrinsic electrical activity drives small-cell lung cancer progression. Peinado P, Stazi M, Ballabio C, Margineanu MB, Li Z, Colon CI, Hsieh MS, Pal Choudhuri S, Stastny V, Hamilton S, Le Marois A, Collingridge J, Conrad L, Chen Y, Ng SR, Magendantz M, Bhutkar A, Chen JS, Sahai E, Drapkin BJ, Jacks T, Vander Heiden MG, Kopanitsa MV, Robinson HPC, Li L. Nature. 2025 Mar;639(8055):765-775. doi: 10.1038/s41586-024-08575-7. Epub 2025 Feb 12. PubMed |
| Promyelocytic Leukemia Protein (PML) Regulates Stem Cell Pluripotency Through Novel Sumoylation Targets. Spanou S, Makatounakis T, Filippopoulou C, Dougalis G, Stamatakis G, Nikolaou C, Samiotaki M, Chachami G, Papamatheakis J, Kretsovali A. Int J Mol Sci. 2025 Jan 28;26(3):1145. doi: 10.3390/ijms26031145. PubMed |
| STT3B promotes porcine epidemic diarrhea virus replication by regulating N-glycosylation of PEDV S protein. Zhu H, Lou J, Yang Z, Bai J, Jiang P, Wang X, Liu X. J Virol. 2025 Mar 18;99(3):e0001825. doi: 10.1128/jvi.00018-25. Epub 2025 Feb 13. PubMed |
Activation of the imprinted Prader-Willi syndrome locus by CRISPR-based epigenome editing.
Rohm D, Black JB, McCutcheon SR, Barrera A, Berry SS, Morone DJ, Nuttle X, de Esch CE, Tai DJC, Talkowski ME, Iglesias N, Gersbach CA.
Cell Genom. 2025 Feb 12;5(2):100770. doi: 10.1016/j.xgen.2025.100770.
PubMed
Associated Plasmids |
Comprehensive dissection of cis-regulatory elements in a 2.8 Mb topologically associated domain in six human cancers.
Caragine CM, Le VT, Mustafa M, Diaz BJ, Morris JA, Muller S, Mendez-Mancilla A, Geller E, Liscovitch-Brauer N, Sanjana NE.
Nat Commun. 2025 Feb 13;16(1):1611. doi: 10.1038/s41467-025-56568-5.
PubMed
Associated Plasmids |
| HIF1alpha controls steroidogenesis under acute hypoxic stress. Ariyeloye S, Watts D, Jaykar MT, Ermis C, Kruger A, Kaden D, Stepien BK, Alexaki VI, Peitzsch M, Bechmann N, Mirtschink P, El-Armouche A, Wielockx B. Cell Commun Signal. 2025 Feb 13;23(1):86. doi: 10.1186/s12964-025-02080-8. PubMed |
| LINC01235 Promotes Clonal Evolution through DNA Replication Licensing-Induced Chromosomal Instability in Breast Cancer. Zhang Q, Wang X, Shao Z, Zhang Y, Zhang L, Chen M, Zhou X, Zhu H, Zhou Y, Lu X, Li P, Chi W, Li L, Shao ZM, Huang S, Xue J, Chi Y, Wu J, Xiu B. Adv Sci (Weinh). 2025 Apr;12(14):e2413527. doi: 10.1002/advs.202413527. Epub 2025 Feb 14. PubMed |
| Inhibition of the Integrated stress response by Epstein-Barr virus oncoprotein LMP1 attenuates epithelial cell differentiation and lytic viral reactivation. Singh DR, Zhang Y, White SJ, Nelson SE, Fogarty SA, Pawelski AS, Kansra AS, Kenney SC. PLoS Pathog. 2025 Feb 14;21(2):e1012934. doi: 10.1371/journal.ppat.1012934. eCollection 2025 Feb. PubMed |
Evaluation of Cas13d as a tool for genetic interaction mapping.
El Kassem G, Hillmer J, Boettcher M.
Nat Commun. 2025 Feb 14;16(1):1631. doi: 10.1038/s41467-025-56747-4.
PubMed
Associated Plasmids |
| CRISPR screening identifies regulators of enhancer-mediated androgen receptor transcription in advanced prostate cancer. Xiang RR, Lee SA, Tyndall CF, Bhatia AR, Yin J, Singler C, Hauk BJ, Kipp MP, Takeda DY. Cell Rep. 2025 Feb 25;44(2):115312. doi: 10.1016/j.celrep.2025.115312. Epub 2025 Feb 14. PubMed |
| Antisense oligonucleotide-mediated TRA2beta poison exon inclusion induces the expression of a lncRNA with anti-tumor effects. Leclair NK, Brugiolo M, Park S, Devoucoux M, Urbanski L, Angarola BL, Yurieva M, Anczukow O. Nat Commun. 2025 Feb 15;16(1):1670. doi: 10.1038/s41467-025-56913-8. PubMed |
| CPT1A-mediated MFF succinylation promotes stemness maintenance in ovarian cancer stem cells. Zhu Y, Chen S, Su H, Meng Y, Zang C, Ning P, Hu L, Shao H. Commun Biol. 2025 Feb 16;8(1):250. doi: 10.1038/s42003-025-07720-w. PubMed |
| Helicobacter pylori CagA elevates FTO to induce gastric cancer progression via a "hit-and-run" paradigm. He B, Hu Y, Wu Y, Wang C, Gao L, Gong C, Li Z, Gao N, Yang H, Xiao Y, Yang S. Cancer Commun (Lond). 2025 May;45(5):608-631. doi: 10.1002/cac2.70004. Epub 2025 Feb 17. PubMed |
| Immunogenicity of virus-like particle vaccine candidates against SARS-CoV-2 infection. Nguyen HT, Garg R, Kroeker A, Gerdts V, Falzarano D, Liu Q. Access Microbiol. 2025 Feb 17;7(2):000925.v3. doi: 10.1099/acmi.0.000925.v3. eCollection 2025. PubMed |
| PARP7 inhibits type I interferon signaling to prevent autoimmunity and lung disease. Jeltema D, Knox K, Dobbs N, Tang Z, Xing C, Araskiewicz A, Yang K, Siordia IR, Matthews J, Cohen M, Yan N. J Exp Med. 2025 May 5;222(5):e20241184. doi: 10.1084/jem.20241184. Epub 2025 Feb 19. PubMed |
| A window-of-opportunity trial reveals mechanisms of response and resistance to navtemadlin in patients with recurrent glioblastoma. Rendo V, Lee EQ, Bossi C, Khuu N, Rudek MA, Pal S, Azazmeh N, Rashid R, Lin JR, Cusick M, Reynolds ARN, Fassinou ACR, Ayoub G, Malinowski S, Lapinskas E, Pisano W, Jeang J, Stopka SA, Regan MS, Spetz J, Desai A, Lieberman F, Palanichamy K, Fisher JD, Pelton K, Huang RY, Sarosiek KA, Nabors LB, Holdhoff M, Danda N, Strowd R, Desideri S, Walbert T, Ye X, Chakravarti A, Sorger PK, Santagata S, Agar NYR, Grossman SA, Alexander BM, Wen PY, Ligon KL, Beroukhim R. Sci Transl Med. 2025 Feb 19;17(786):eadn6274. doi: 10.1126/scitranslmed.adn6274. Epub 2025 Feb 19. PubMed |
| Tumour-wide RNA splicing aberrations generate actionable public neoantigens. Kwok DW, Stevers NO, Etxeberria I, Nejo T, Colton Cove M, Chen LH, Jung J, Okada K, Lakshmanachetty S, Gallus M, Barpanda A, Hong C, Chan GKL, Liu J, Wu SH, Ramos E, Yamamichi A, Watchmaker PB, Ogino H, Saijo A, Du A, Grishanina NR, Woo J, Diaz A, Hervey-Jumper SL, Chang SM, Phillips JJ, Wiita AP, Klebanoff CA, Costello JF, Okada H. Nature. 2025 Mar;639(8054):463-473. doi: 10.1038/s41586-024-08552-0. Epub 2025 Feb 19. PubMed |
| Cullin-RING ligase BioE3 reveals molecular-glue-induced neosubstrates and rewiring of the endogenous Cereblon ubiquitome. Merino-Cacho L, Barroso-Gomila O, Pozo-Rodriguez M, Muratore V, Guinea-Perez C, Serrano A, Perez C, Cano-Lopez S, Urcullu A, Azkargorta M, Iloro I, Galdeano C, Juarez-Jimenez J, Mayor U, Elortza F, Barrio R, Sutherland JD. Cell Commun Signal. 2025 Feb 19;23(1):101. doi: 10.1186/s12964-025-02091-5. PubMed |
| Epigenetic priming promotes acquisition of tyrosine kinase inhibitor resistance and oncogene amplification in human lung cancer. Starble RM, Sun EG, Gbyli R, Radda J, Lu J, Jensen TB, Sun N, Khudaverdyan N, Hu B, Melnick MA, Zhao S, Roper N, Wang GG, Song J, Politi K, Wang S, Xiao AZ. bioRxiv [Preprint]. 2025 Jan 27:2025.01.26.634826. doi: 10.1101/2025.01.26.634826. PubMed |
| Molecular determinants of RNase MRP specificity and function. Smith EM, Ly J, Haug S, Cheeseman IM. bioRxiv [Preprint]. 2025 Jan 28:2025.01.28.635360. doi: 10.1101/2025.01.28.635360. PubMed |
| Massively parallel assessment of gene regulatory activity at human cortical structure associated variants. Matoba N, McAfee JC, Krupa O, Bell J, Le BD, Valone JM, Crawford GE, Won H, Stein JL. bioRxiv [Preprint]. 2025 Feb 13:2025.02.08.635393. doi: 10.1101/2025.02.08.635393. PubMed |
| Haplotype rather than single causal variants effects contribute to regulatory gene expression associations in human myeloid cells. Greenwood E, Cao M, Lee CM, Liu A, Moyo B, Bao G, Gibson G. bioRxiv [Preprint]. 2025 Jan 30:2025.01.30.635675. doi: 10.1101/2025.01.30.635675. PubMed |
| Multiplex, multimodal mapping of variant effects in secreted proteins. Popp NA, Powell RL, Wheelock MK, Holmes KJ, Zapp BD, Sheldon KM, Fletcher SN, Wu X, Fayer S, Rubin AF, Lannert KW, Chang AT, Sheehan JP, Johnsen JM, Fowler DM. bioRxiv [Preprint]. 2025 Jan 29:2024.04.01.587474. doi: 10.1101/2024.04.01.587474. PubMed |
| TRIP13 protects pancreatic cancer cells against intrinsic and therapy-induced DNA replication stress. Anand JR, Droby GN, Joseph S, Patel U, Zhang X, Klomp JA, Der CJ, Purvis JE, Wolff SC, Bowser J, Vaziri C. bioRxiv [Preprint]. 2025 Jan 27:2025.01.26.634889. doi: 10.1101/2025.01.26.634889. PubMed |
| Higher throughput assays for understanding the pathogenicity of variants of unknown significance (VUS) in the RPE65 gene. Pormehr LA, Manian KV, Cho HE, Comander J. bioRxiv [Preprint]. 2025 Feb 5:2025.01.31.635952. doi: 10.1101/2025.01.31.635952. PubMed |
| Single-cell sequencing elucidates the mechanism of NUSAP1 in glioma and its diagnostic and prognostic significance. Zhao MY, Shen ZL, Dai H, Xu WY, Wang LN, Gu Y, Zhao JH, Yu TH, Wang CZ, Xu JF, Chen GJ, Chen DH, Hong WM, Zhang F. Front Immunol. 2025 Feb 5;16:1512867. doi: 10.3389/fimmu.2025.1512867. eCollection 2025. PubMed |
| Mechanism of Centrosomal Protein 55 (CEP55) Loading Into Exosomes. Dahlstroem C, Barezani J, Li J, Sopelniak K, Muhs S, Schneider C, Thunauer R, Reimer R, Windhorst S. J Extracell Vesicles. 2025 Feb;14(2):e70046. doi: 10.1002/jev2.70046. PubMed |
| Development of ketobenzothiazole-based peptidomimetic TMPRSS13 inhibitors with low nanomolar potency. Joushomme A, Desilets A, Champagne W, Hassanzadeh M, Lemieux G, Gravel-Trudeau A, Lepage M, Lafreniere S, Froehlich U, List K, Boudreault PL, Leduc R. J Enzyme Inhib Med Chem. 2025 Dec;40(1):2466841. doi: 10.1080/14756366.2025.2466841. Epub 2025 Feb 20. PubMed |
| Lanatoside C activates the E3 ligase STUB1 to inhibit FOXP3 transcriptional activity and promote antitumor immunity. Zhou Q, Yang T, Yu X, Li B, Liu J, Mao Y, Guo R, Feng Z, Zhou L, Zeng G, Li N, Liang J, Liu L, Feng P, Shu HB, Chen L. EMBO Mol Med. 2025 Mar;17(3):563-588. doi: 10.1038/s44321-025-00200-y. Epub 2025 Feb 20. PubMed |
| Restraint of inflammasome-driven cytokine responses through the mRNA stability protein TTP. O'Keefe ME, Kondolf HC, De Santis S, Pizarro TT, Abbott DW. Cell Rep. 2025 Mar 25;44(3):115340. doi: 10.1016/j.celrep.2025.115340. Epub 2025 Feb 20. PubMed |
| Rapid and high-throughput screening of proteolysis targeting chimeras using a dual-reporter system expressing fluorescence protein and luciferase. Meng S, Meng Y, Yang X, Yu W, Li B, Liu T, Zhang J, Ren X, Zhang L. BMC Biol. 2025 Feb 21;23(1):51. doi: 10.1186/s12915-025-02153-7. PubMed |
| Integration of single-cell and bulk RNA sequencing to identify a distinct tumor stem cells and construct a novel prognostic signature for evaluating prognosis and immunotherapy in LUAD. Zhao F, Chen M, Wu T, Ji M, Li F. J Transl Med. 2025 Feb 22;23(1):222. doi: 10.1186/s12967-025-06243-6. PubMed |
| Distinct outcomes from targeted perturbations of the multi-subunit SCF(Skp2) E3 ubiquitin ligase in blocking Trp53/Rb1-null prostate tumorigenesis. Xue Y, Zhu L, Karan S, Locker JD, Branch C, Zhang J, Hoang B, Maianti JP, Zhao H, Schwartz EL. Commun Biol. 2025 Feb 22;8(1):278. doi: 10.1038/s42003-025-07662-3. PubMed |
| CCCTC-binding factor N-terminal domain regulates clustered protocadherin gene expression by enhancing cohesin processivity. Zhang Y, Wu Q. J Biol Chem. 2025 Apr;301(4):108337. doi: 10.1016/j.jbc.2025.108337. Epub 2025 Feb 21. PubMed |
| A functional map of phosphoprotein phosphatase regulation identifies an evolutionary conserved reductase for the catalytic metal ions. Meeusen B, Ambjorn SM, Veis J, Riley RC, Vit G, Brauer BL, Moller MH, Greiner EC, Chan CB, Weisser MB, Garvanska DH, Zhu H, Davey NE, Kettenbach AN, Ogris E, Nilsson J. bioRxiv [Preprint]. 2025 Feb 16:2025.02.12.637884. doi: 10.1101/2025.02.12.637884. PubMed |
| Optical Pooled Screening for the Discovery of Regulators of the Alternative Lengthening of Telomeres Pathway. Quintanilla I, Azeroglu B, Sagar MAK, Stracker TH, Denchi EL, Pegoraro G. bioRxiv [Preprint]. 2025 Feb 16:2025.02.15.638448. doi: 10.1101/2025.02.15.638448. PubMed |
| A novel alpha-synuclein K58N missense variant in a patient with Parkinson's disease. Al-Azzani M, Weber S, Ramalingam N, Ramon M, Shvachiy L, Mestre G, Zech M, Sicking K, de Opakua AI, Jayanthi V, Amaral L, Agarwal A, Chandran A, Chaves SR, Winkelmann J, Trenkwalder C, Schwager M, Pauli S, Dettmer U, Fernandez CO, Lautenschlager J, Zweckstetter M, Busnadiego RF, Mollenhauer B, Outeiro TF. medRxiv [Preprint]. 2025 Feb 14:2025.02.07.25321793. doi: 10.1101/2025.02.07.25321793. PubMed |
| The Glycosyltransferase XYLT1 Activates NF-kappaB Signaling to Promote Metastasis of Early-Stage Lung Adenocarcinoma. Han J, Du J, Li X, Zhou Q, Zeng J, Lin JT, Zhou W, Cai J, Ye Y, Yang B, Wang J, Zhou X, Lian R, Yang Y, Zhu X, Guan H, Liu L, Cai J, Wu J, Li Y, Li M, Tian H. Cancer Res. 2025 May 2;85(9):1628-1643. doi: 10.1158/0008-5472.CAN-24-1893. PubMed |
| Tumorigenesis Driven by BRAFV600E Requires Secondary Mutations That Overcome Its Feedback Inhibition of RAC1 and Migration. Gadal S, Boyer JA, Roy SF, Outmezguine NA, Sharma M, Li H, Fan N, Chan E, Romin Y, Barlas A, Chang Q, Pancholi P, Timaul NM, Overholtzer M, Yaeger R, Manova-Todorova K, de Stanchina E, Bosenberg MW, Rosen N. Cancer Res. 2025 May 2;85(9):1611-1627. doi: 10.1158/0008-5472.CAN-24-2220. PubMed |
| Circadian clock features define novel subtypes among breast cancer cells and shape drug sensitivity. Ector C, Didier J, De Landtsheer S, Nordentoft MS, Schmal C, Keilholz U, Herzel H, Kramer A, Sauter T, Granada AE. Mol Syst Biol. 2025 Apr;21(4):315-340. doi: 10.1038/s44320-025-00092-7. Epub 2025 Feb 24. PubMed |
| TMEM97 governs partial epithelial-mesenchymal transition of retinal pigment epithelial cells via the CTNND2-ADAM10 axis. Li J, Nagasaka Y, Shen H, Zhou X, Ma J, Trevisan-Silva D, Sherman NE, Ambati J, Gelfand BD, Guo LW. Mol Ther Nucleic Acids. 2025 Jan 21;36(1):102460. doi: 10.1016/j.omtn.2025.102460. eCollection 2025 Mar 11. PubMed |
| Combinational Inhibition of MEK and AKT Synergistically Induces Melanoma Stem Cell Apoptosis and Blocks NRAS Tumor Growth. Alobaidi R, Islam N, Olkey T, Haribabu Y, Shamo M, Sykora P, Simbulan-Rosenthal CM, Rosenthal DS. Cells. 2025 Feb 10;14(4):248. doi: 10.3390/cells14040248. PubMed |
| ATF3-SLC7A7 Axis Regulates mTORC1 Signaling to Suppress Lipogenesis and Tumorigenesis in Hepatocellular Carcinoma. Zhang Q, Zhu F, Tong Y, Huang Y, Zhang J. Cells. 2025 Feb 11;14(4):253. doi: 10.3390/cells14040253. PubMed |
| RNF20 dual regulation of MDA5 signaling to maintain immune homeostasis in chickens. Wang J, Liu Q, Zhang K, Zhao S, Shao Q, Fu F, Ma J, Wang Z, Yan Y-x, Wang H, Sun J, Cheng Y. J Virol. 2025 Mar 18;99(3):e0200824. doi: 10.1128/jvi.02008-24. Epub 2025 Feb 25. PubMed |
| Engineering of CD8(+) T cells with an HIV-specific synthetic notch receptor to secrete broadly therapeutic antibodies for combining antiviral humoral and cellular immune responses. Meng L, Zhao H, Chang S, Li W, Tian Y, Wang R, Wang L, Gu T, Wu J, Yu B, Wang C, Yu X. mBio. 2025 Apr 9;16(4):e0383924. doi: 10.1128/mbio.03839-24. Epub 2025 Feb 25. PubMed |
| Genome-wide profiling of N6-methyladenosine-modified pseudogene-derived long noncoding RNAs reveals the tumour-promoting and innate immune-restraining function of RPS15AP12 in ovarian cancer. Xu J, Ren Y, Lu J, Qin F, Yang D, Tang C, Yang Y, Xu J, Liu T, Yi P. Clin Transl Med. 2025 Mar;15(3):e70249. doi: 10.1002/ctm2.70249. PubMed |
| Impaired MC3T3-E1 osteoblast differentiation triggered by oncogenic HRAS is rescued by the farnesyltransferase inhibitor Tipifarnib. Andrasch Y, Ireri MM, Gander J, Timm AS, Chennappan S, Fidan M, Engler M, Cirstea IC. Sci Rep. 2025 Feb 26;15(1):6832. doi: 10.1038/s41598-025-91592-x. PubMed |
| Glutathione peroxidase 4 (GPX4) and obesity interact to impact tumor progression and treatment response in triple negative breast cancer. Devericks EN, Brosnan BH, Ho AN, Glenny EM, Malian HM, Teegarden D, Wendt MK, Coleman MF, Hursting SD. Cancer Metab. 2025 Feb 25;13(1):11. doi: 10.1186/s40170-025-00380-8. PubMed |
| Stbd1 stimulates AMPK signaling and alleviates insulin resistance in an in vitro hepatocyte model. Theodoulou A, Speckmann T, Potamiti L, Baba O, Morita T, Drousiotou A, Panayiotidis MI, Schurmann A, Petrou PP. FEBS J. 2025 Jun;292(11):2882-2901. doi: 10.1111/febs.70040. Epub 2025 Feb 25. PubMed |
| Association of Selected STAT Inhibitors with Prolactin-Induced Protein (PIP) in Breast Cancer. Jablonska K, Kmiecik A, Nowinska K, Piotrowska A, Suchanski J, Ratajczak-Wielgomas K, Partynska A, Romanowicz H, Smolarz B, Matkowski R, Dziegiel P. Int J Mol Sci. 2025 Feb 7;26(4):1416. doi: 10.3390/ijms26041416. PubMed |
| The IGF2BP1 oncogene is a druggable m(6)A-dependent enhancer of YAP1-driven gene expression in ovarian cancer. Schott A, Simon T, Muller S, Rausch A, Busch B, Glass M, Misiak D, Dipto M, Elrewany H, Peters LM, Tripathee S, Ghazy E, Muller F, Rolnik RB, Lederer M, Hmedat A, Vetter M, Wallwiener M, Sippl W, Huttelmaier S, Bley N. NAR Cancer. 2025 Feb 24;7(1):zcaf006. doi: 10.1093/narcan/zcaf006. eCollection 2025 Mar. PubMed |
| Local soft niches in mechanically heterogeneous primary tumors promote brain metastasis via mechanotransduction-mediated HDAC3 activity. Tang K, Zheng Y, Hu G, Xin Y, Li K, Zhang C, Chen X, Zhang B, Li X, Hu B, Jia Q, Zheng YP, Yang M, Tan Y. Sci Adv. 2025 Feb 28;11(9):eadq2881. doi: 10.1126/sciadv.adq2881. Epub 2025 Feb 26. PubMed |
| NGF regulates survival and differentiation of umbilical mesenchymal stem/stromal cells into GABAergic, dopaminergic and cholinergic lineages. Borkowska P, Kowalczyk M, Zielinska A, Poskrobko K, Rother MB, Paul-Samojedny M, Kowalski J. Eur J Pharm Sci. 2025 May 1;208:107053. doi: 10.1016/j.ejps.2025.107053. Epub 2025 Feb 24. PubMed |
| Dysregulation of mitochondrial alpha-ketoglutarate dehydrogenase leads to elevated lipid peroxidation in CHCHD2-linked Parkinson's disease models. Gao G, Shi Y, Deng HX, Krainc D. Nat Commun. 2025 Feb 26;16(1):1982. doi: 10.1038/s41467-025-57142-9. PubMed |
| A benchmark comparison of CRISPRn guide-RNA design algorithms and generation of small single and dual-targeting libraries to boost screening efficiency. Lukasiak S, Kalinka A, Gupta N, Papadopoulos A, Saeed K, McDermott U, Hannon GJ, Ross-Thriepland D, Walter D. BMC Genomics. 2025 Feb 26;26(1):198. doi: 10.1186/s12864-025-11386-3. PubMed |
| Maintenance of p-eIF2alpha levels by the eIF2B complex is vital for colorectal cancer. Skapik IP, Giacomelli C, Hahn S, Deinlein H, Gallant P, Diebold M, Biayna J, Hendricks A, Olimski L, Otto C, Kastner C, Wolf E, Schulein-Volk C, Maurus K, Rosenwald A, Schleussner N, Jackstadt RF, Schlegel N, Germer CT, Bushell M, Eilers M, Schmidt S, Wiegering A. EMBO J. 2025 Apr;44(7):2075-2105. doi: 10.1038/s44318-025-00381-9. Epub 2025 Feb 27. PubMed |
| Accumulation of Damaging Lipids in the Arf1-Ablated Neurons Promotes Neurodegeneration through Releasing mtDNA and Activating Inflammatory Pathways in Microglia. Li X, Jin S, Wang D, Wu Y, Tang X, Liu Y, Yao T, Han S, Sun L, Wang Y, Hou SX. Adv Sci (Weinh). 2025 Apr;12(16):e2414260. doi: 10.1002/advs.202414260. Epub 2025 Feb 28. PubMed |
| Norovirus co-opts NINJ1 for selective protein secretion. Song J, Zhang L, Moon S, Fang A, Wang G, Gheshm N, Loeb SA, Cao P, Wallace JR, Alfajaro MM, Strine MS, Beatty WL, Jamieson AM, Orchard RC, Robinson BA, Nice TJ, Wilen CB, Orvedahl A, Reese TA, Lee S. Sci Adv. 2025 Feb 28;11(9):eadu7985. doi: 10.1126/sciadv.adu7985. Epub 2025 Feb 28. PubMed |
| Metabolic engineering to facilitate anti-tumor immunity. Schild T, Wallisch P, Zhao Y, Wang YT, Haughton L, Chirayil R, Pierpont K, Chen K, Nunes-Violante S, Cross J, de Stanchina E, Thompson CB, Scheinberg DA, Perry JSA, Keshari KR. Cancer Cell. 2025 Mar 10;43(3):552-562.e9. doi: 10.1016/j.ccell.2025.02.004. Epub 2025 Feb 27. PubMed |
| Bone morphogenetic protein (BMP) signaling determines neuroblastoma cell fate and sensitivity to retinoic acid. Pan M, Zhang Y, Wright WC, Liu X, Passaia B, Currier D, Low J, Chapple RH, Steele JA, Connelly JP, Ju B, Plyler E, Lu M, Loughran AJ, Yang L, Abraham BJ, Pruett-Miller SM, Freeman B 3rd, Campbell GE, Dyer MA, Chen T, Stewart E, Koo S, Sheppard H, Easton J, Geeleher P. Nat Commun. 2025 Feb 28;16(1):2036. doi: 10.1038/s41467-025-57185-y. PubMed |
| ACSS2 drives senescence-associated secretory phenotype by limiting purine biosynthesis through PAICS acetylation. Yang L, You J, Yang X, Jiao R, Xu J, Zhang Y, Mi W, Zhu L, Ye Y, Ren R, Min D, Tang M, Chen L, Li F, Liu P. Nat Commun. 2025 Feb 28;16(1):2071. doi: 10.1038/s41467-025-57334-3. PubMed |
| Serotonergic Psychedelics Rapidly Modulate Evoked Glutamate Release in Cultured Cortical Neurons. Petruskova A, Guhathakurta D, Akdas EY, Perello-Amoros B, Frischknecht R, Weiss EM, Palenicek T, Fejtova A. J Neurochem. 2025 Mar;169(3):e70020. doi: 10.1111/jnc.70020. PubMed |
HIF regulates multiple translated endogenous retroviruses: Implications for cancer immunotherapy.
Jiang Q, Braun DA, Clauser KR, Ramesh V, Shirole NH, Duke-Cohan JE, Nabilsi N, Kramer NJ, Forman C, Lippincott IE, Klaeger S, Phulphagar KM, Chea V, Kim N, Vanasse AP, Saad E, Parsons T, Carr-Reynolds M, Carulli I, Pinjusic K, Jiang Y, Li R, Syamala S, Rachimi S, Verzani EK, Stevens JD, Lane WJ, Camp SY, Meli K, Pappalardi MB, Herbert ZT, Qiu X, Cejas P, Long HW, Shukla SA, Van Allen EM, Choueiri TK, Churchman LS, Abelin JG, Gurer C, MacBeath G, Childs RW, Carr SA, Keskin DB, Wu CJ, Kaelin WG Jr.
Cell. 2025 Feb 25:S0092-8674(25)00156-4. doi: 10.1016/j.cell.2025.01.046.
PubMed
Associated Plasmids |
| Integrated computational analysis identifies therapeutic targets with dual action in cancer cells and T cells. Luo C, Zhang R, Guo R, Wu L, Xue T, He Y, Jin Y, Zhao Y, Zhang Z, Zhang P, Ye S, Li X, Li D, Zhang W, Wang C, Lai L, Pan-Hammarstrom Q, Wucherpfennig KW, Gao Z, Pan D, Zeng Z. Immunity. 2025 Mar 11;58(3):745-765.e9. doi: 10.1016/j.immuni.2025.02.007. Epub 2025 Feb 28. PubMed |
| The NF1 tumor suppressor regulates PD-L1 and immune evasion in melanoma. Berry D, Moldoveanu D, Rajkumar S, Lajoie M, Lin T, Tchelougou D, Sakthivel S, Sharon I, Bernard A, Pelletier S, Ripstein Y, Spatz A, Miller WH, Jamal R, Lapointe R, Mes-Masson AM, Petrecca K, Meguerditchian AN, Richardson K, Wang B, Chergui M, Guiot MC, Watters K, Stagg J, Schmeing TM, Rodier F, Turcotte S, Mihalcioiu C, Meterissian S, Watson IR. Cell Rep. 2025 Mar 25;44(3):115365. doi: 10.1016/j.celrep.2025.115365. Epub 2025 Mar 1. PubMed |
| Suppression of the LKB1-AMPK-SLC7A11-GSH signaling pathway sensitizes NSCLC to albumin-bound paclitaxel via oxidative stress. Rong D, Gao L, Chen Y, Gao XZ, Tang M, Tang H, Gao Y, Lu G, Ling ZQ, Shen HM. Redox Biol. 2025 Apr;81:103567. doi: 10.1016/j.redox.2025.103567. Epub 2025 Feb 25. PubMed |
| Screening the human druggable genome identifies ABHD17B as an anti-fibrotic target in hepatic stellate cells. Li W, Sparks RP, Sun C, Yang Y, Pantano L, Kirchner R, Arghiani N, Weilheimer A, Toles BJ, Chen JY, Moran SP, Barrera V, Li Z, Zhou P, Brassil ML, Wrobel D, Ho Sui SJ, Aspnes G, Schuler M, Smith J, Medoff BD, Zhou C, Boustany-Kari CM, Rippmann JF, Santos DM, Doerner JF, Mullen AC. Nat Commun. 2025 Mar 2;16(1):2109. doi: 10.1038/s41467-025-56900-z. PubMed |
| Dickkopf-1 promotes tumor progression of gefitinib- resistant non-small cell lung cancer through cancer cell-fibroblast interactions. Choi M, Choi YJ, Lee YJ, Lee Y, Chung JH, Kang KW. Exp Hematol Oncol. 2025 Mar 1;14(1):24. doi: 10.1186/s40164-025-00616-9. PubMed |
| Synergistic RAS-MAPK and AKT Activation in MYC-Driven Tumors via Adjacent PVT1 Rearrangements. Tiwari A, Paithane U, Friedlein J, Tashiro K, Saulnier O, Barbosa K, Trinh Q, Hall B, Saha S, Soni A, Nakashima T, Bobkov A, Fujimoto LM, Murad R, Maurya S, Saraswat M, Sarmashghi S, Lange JT, Wu S, Masihi MB, Ghosh S, Hemmati G, Chapman O, Hendrikse L, James B, Luebeck J, Eisemann T, Tzaridis T, Rohila D, Leary R, Varshney J, Konety B, Dehm SM, Kawakami Y, Beroukhim R, Largaespada DA, Stein L, Chavez L, Suzuki H, Weiss WA, Zhao J, Deshpande A, Wechsler-Reya RJ, Taylor MD, Bagchi A. bioRxiv [Preprint]. 2025 Feb 22:2025.02.17.638454. doi: 10.1101/2025.02.17.638454. PubMed |
| CHIP protects lysosomes from CLN4 mutant-induced membrane damages. Lee J, Zou J, Binti Mazli WNA, Chin N, Jarnik M, Saidi L, Xu Y, Replogle J, Ward M, Bonifacino J, Zheng W, Hao L, Ye Y. bioRxiv [Preprint]. 2025 Feb 19:2025.02.18.638932. doi: 10.1101/2025.02.18.638932. PubMed |
| CellFIE: Integrating Pathway Discovery With Pooled Profiling of Perturbations Uncovers Pathways of Huntington's Disease, Including Genetic Modifiers of Neuronal Development and Morphology. Kang B, Murphy M, Ng CW, Leventhal MJ, Huynh N, Im E, Danquah S, Housman DE, Nehme R, Farhi SL, Fraenkel E. bioRxiv [Preprint]. 2025 Feb 22:2025.02.19.639023. doi: 10.1101/2025.02.19.639023. PubMed |
| Pyrimethamine and a potent analogue WCDD115 inhibit NRF2 by suppressing DHFR and one-carbon metabolism. Chembo J, Bowman BM, Lapak K, Wilkerson E, Paiboonrungruang C, Cho K, Medcalf MR, Patti GJ, Dolle RE, Chen X, Zolkind P, Major MB. bioRxiv [Preprint]. 2025 Feb 17:2025.02.13.637433. doi: 10.1101/2025.02.13.637433. PubMed |
| An RNA Splicing System that Excises Transposons from Animal mRNAs. Zhao LW, Nardone C, Paulo JA, Elledge SJ, Kennedy S. bioRxiv [Preprint]. 2025 Feb 17:2025.02.14.638102. doi: 10.1101/2025.02.14.638102. PubMed |
| Proximity proteomics reveals a mechanism of fatty acid transfer at lipid droplet-mitochondria- endoplasmic reticulum contact sites. Bezawork-Geleta A, Devereux CJ, Keenan SN, Lou J, Cho E, Nie S, De Souza DP, Narayana VK, Siddall NA, Rodrigues CHM, Portelli S, Zheng T, Nim HT, Ramialison M, Hime GR, Dodd GT, Hinde E, Ascher DB, Stroud DA, Watt MJ. Nat Commun. 2025 Mar 3;16(1):2135. doi: 10.1038/s41467-025-57405-5. PubMed |
| Nematode serine protease inhibitor SPI-I8 negatively regulates host NF-kappaB signalling by hijacking MKRN1-mediated polyubiquitination of RACK1. Wu F, Chen Y, Chen X, Tong D, Zhou J, Du Z, Yao C, Yang Y, Du A, Ma G. Commun Biol. 2025 Mar 3;8(1):356. doi: 10.1038/s42003-025-07803-8. PubMed |
| Packaged delivery of CRISPR-Cas9 ribonucleoproteins accelerates genome editing. Karp H, Zoltek M, Wasko K, Vazquez AL, Brim J, Ngo W, Schepartz A, Doudna JA. Nucleic Acids Res. 2025 Feb 27;53(5):gkaf105. doi: 10.1093/nar/gkaf105. PubMed |
| Gut dysbiosis conveys psychological stress to activate LRP5/beta-catenin pathway promoting cancer stemness. Cui B, Luo H, He B, Liu X, Lv D, Zhang X, Su K, Zheng S, Lu J, Wang C, Yang Y, Zhao Z, Liu X, Wang X, Zhao Y, Nie X, Jiang Y, Zhang Z, Liu C, Chen X, Cai A, Lv Z, Liu Z, An F, Zhang Y, Yan Q, Kelley KW, Xu G, Xu L, Liu Q, Peng F. Signal Transduct Target Ther. 2025 Mar 5;10(1):79. doi: 10.1038/s41392-025-02159-1. PubMed |
| p53 regulates DREAM complex-mediated repression in a p21-independent manner. Agrawal R, Sengupta S. EMBO J. 2025 Apr;44(8):2279-2297. doi: 10.1038/s44318-025-00402-7. Epub 2025 Mar 4. PubMed |
| Deletion of Xist repeat B disrupts cell cycle and asymmetric cell division through Usp9x hyperactivation in mice. Liang M, Zhang L, Gong H, Yang L, Wang H, Song N, Lai L, Xie W, Li Z. Nucleic Acids Res. 2025 Feb 27;53(5):gkaf142. doi: 10.1093/nar/gkaf142. PubMed |
| Mis-splicing drives loss of function of p53E224D point mutation. Lock IC, Leisenring NH, Floyd W, Xu ES, Luo L, Ma Y, Mansell EC, Cardona DM, Lee CL, Kirsch DG. PLoS One. 2025 Mar 5;20(3):e0318856. doi: 10.1371/journal.pone.0318856. eCollection 2025. PubMed |
| Structure-function relationship of ASH1L and histone H3K36 and H3K4 methylation. Vann KR, Sharma R, Hsu CC, Devoucoux M, Tencer AH, Zeng L, Lin K, Zhu L, Li Q, Lachance C, Ospina RR, Tong Q, Cheung KL, Yang S, Biswas S, Xuan H, Gatchalian J, Alamillo L, Wang J, Jang SM, Klein BJ, Lu Y, Ernst P, Strahl BD, Rothbart SB, Walsh MJ, Cleary ML, Cote J, Shi X, Zhou MM, Kutateladze TG. Nat Commun. 2025 Mar 6;16(1):2235. doi: 10.1038/s41467-025-57556-5. PubMed |
| The TCF4 Gene Regulates Apoptosis of Corneal Endothelial Cells in Fuchs Endothelial Corneal Dystrophy. Nakagawa T, Honda T, Yuasa T, Nishiuchi G, Sato M, Tokunaga A, Nakahara M, Tourtas T, Schlotzer-Schrehardt U, Kruse F, Padmanabhan P, Chatterjee A, Sathe G, Ghose V, Janakiraman N, Blake DJ, Koizumi N, Elchuri S, Okumura N. Invest Ophthalmol Vis Sci. 2025 Mar 3;66(3):16. doi: 10.1167/iovs.66.3.16. PubMed |
| Enhancing Prime Editing Efficiency Through Modulation of Methylation on the Newly Synthesized DNA Strand and Prolonged Expression. Han X, Xu X, Xiong Y, Zhao G, He R, Su Y, Li S, Zhao C, Xi X, Zhao Y, Xu X, Xie S, Wang H, Li X, Zhao S, Ruan J. Adv Sci (Weinh). 2025 May;12(17):e2417790. doi: 10.1002/advs.202417790. Epub 2025 Mar 7. PubMed |
| Heme oxygenase 1‑overexpressing bone marrow mesenchymal stem cell‑derived exosomes suppress interleukin‑1 beta‑induced apoptosis and aging of nucleus pulposus cells. Zhang H, Zhang D, Wang H, Liu Y, Ding W, Fan G, Meng X. Mol Med Rep. 2025 May;31(5):116. doi: 10.3892/mmr.2025.13481. Epub 2025 Mar 7. PubMed |
| Rac1 overexpression promotes Treg-derived cytokines to mediate choroidal neovascularization in wet age-related macular degeneration. Li J, Ren Y, Li H, Zheng Z. Braz J Med Biol Res. 2025 Mar 3;58:e14187. doi: 10.1590/1414-431X2024e14187. eCollection 2025. PubMed |
| Isocyanic acid-mediated NLRP3 carbamoylation reduces NLRP3-NEK7 interaction and limits inflammasome activation. Zhang Z, Chen C, Liu C, Sun P, Liu P, Fang S, Li X. Sci Adv. 2025 Mar 7;11(10):eadq4266. doi: 10.1126/sciadv.adq4266. Epub 2025 Mar 7. PubMed |
| Targeted nanoparticle delivery system for tumor-associated macrophage reprogramming to enhance TNBC therapy. Dong X, Wang X, Zheng X, Jiang H, Liu L, Ma N, Wang S. Cell Biol Toxicol. 2025 Mar 8;41(1):58. doi: 10.1007/s10565-025-10001-1. PubMed |
| Single extracellular vesicle detection assay identifies membrane-associated alpha-synuclein as an early-stage biomarker in Parkinson's disease. Yan S, Zhang W, Li X, Dutta S, Castle AR, Liu Y, Sahoo A, Lam CL, Gatford NJF, Hu MT, Li CZ, Jiang C, Shu B, Tofaris GK. Cell Rep Med. 2025 Mar 18;6(3):101999. doi: 10.1016/j.xcrm.2025.101999. Epub 2025 Mar 7. PubMed |
| HRP2 regulating MICU1-mediated Ca(2+) overload to dictate chemoresistance of multiple myeloma. Li Q, Peng Z, Lin L, Zhang Z, Ma J, Chen L, Liu S, Gao S, Jia L, Wang J, Cao Z, Zhao X, Liu Z, Wang Y. Neoplasia. 2025 Apr;62:101150. doi: 10.1016/j.neo.2025.101150. Epub 2025 Mar 8. PubMed |
| Resistance to Radiation Enhances Metastasis by Altering RNA Metabolism. Kumar A, Kishimoto K, Goel HL, Wisniewski CA, Li R, Pacheco B, Zhu LJ, Flavahan WA, Mercurio AM. bioRxiv [Preprint]. 2025 Feb 25:2025.02.19.638943. doi: 10.1101/2025.02.19.638943. PubMed |
| Multiplexed in vivo base editing identifies functional gene-variant-context interactions. Acosta J, Johnson GA, Gould SI, Dong K, Lendner Y, Detres D, Atwa O, Bulkens J, Gruber S, Contreras ME, Wuest AN, Narendra VK, Hemann MT, Sanchez-Rivera FJ. bioRxiv [Preprint]. 2025 Feb 26:2025.02.23.639770. doi: 10.1101/2025.02.23.639770. PubMed |
| Succinate dehydrogenase activity supports de novo purine synthesis. Nengroo MA, Klein AT, Carr HS, Vidal-Cruchez O, Sahu U, McGrail DJ, Sahni N, Gao P, Asara JM, Shah H, Mendillo ML, Ben-Sahra I. bioRxiv [Preprint]. 2025 Mar 1:2025.02.26.640389. doi: 10.1101/2025.02.26.640389. PubMed |
| A genome wide CRISPR screen reveals novel determinants of long-lived plasma cell secretory capacity. D'Souza LJ, Young JN, Coffman H, Petrow EP Jr, Bhattacharya D. bioRxiv [Preprint]. 2025 Mar 2:2025.02.28.640639. doi: 10.1101/2025.02.28.640639. PubMed |
| Harnessing transcriptional regulation of alternative end-joining to predict cancer treatment. Espin R, Medina-Jover F, Siguenza-Andrade J, Farran-Matas S, Mateo F, Figueras A, Sanz RT, Vicent GP, Shabbir A, Ruiz-Auladell L, Racionero-Andres E, Garcia I, Baiges A, Franco-Luzon L, Martinez-Tebar A, Pardo-Cea MA, Martinez-Iniesta M, Wang XC, Cuyas E, Menendez JA, Lopez-Cerda M, Munoz P, Richaud I, Raya A, Fabregat I, Villanueva A, Serrat X, Ceron J, Alemany M, Guix I, Herencia-Ropero A, Serra V, Krishnan R, Mekhail K, Hakem R, Bruna J, Barcellos-Hoff MH, Vinals F, Aytes A, Pujana MA. NAR Cancer. 2025 Mar 7;7(1):zcaf007. doi: 10.1093/narcan/zcaf007. eCollection 2025 Mar. PubMed |
| TNF inhibits NKCC2 phosphorylation by a calcineurin-dependent pathway. Hao S, Lasaracina AP, Epps J, Ferreri NR. Am J Physiol Renal Physiol. 2025 Apr 1;328(4):F489-F500. doi: 10.1152/ajprenal.00251.2024. Epub 2025 Mar 10. PubMed |
| CRB2 depletion induces YAP signaling and disrupts mechanosensing in podocytes. Sun Y, Kronenberg NM, Sethi SK, Dash SN, Kovalik ME, Sempowski B, Strickland S, Raina R, Sperati CJ, Tian X, Ishibe S, Hall G, Gather MC. Am J Physiol Renal Physiol. 2025 Apr 1;328(4):F578-F595. doi: 10.1152/ajprenal.00318.2024. Epub 2025 Mar 10. PubMed |
| Antibody reactivity against EBNA1 and GlialCAM differentiates multiple sclerosis patients from healthy controls. Sattarnezhad N, Kockum I, Thomas OG, Liu Y, Ho PP, Barrett AK, Comanescu AI, Wijeratne TU, Utz PJ, Alfredsson L, Steinman L, Robinson WH, Olsson T, Lanz TV. Proc Natl Acad Sci U S A. 2025 Mar 18;122(11):e2424986122. doi: 10.1073/pnas.2424986122. Epub 2025 Mar 10. PubMed |
| A positive feedback loop between SMAD3 and PINK1 in regulation of mitophagy. Tang M, Rong D, Gao X, Lu G, Tang H, Wang P, Shao NY, Xia D, Feng XH, He WF, Chen W, Lu JH, Liu W, Shen HM. Cell Discov. 2025 Mar 11;11(1):22. doi: 10.1038/s41421-025-00774-4. PubMed |
| Suppression of stress granule formation is a vulnerability imposed by mutant p53. Thoenen E, Ranjan A, Parrales A, Nishikawa S, Dixon DA, Oka S, Iwakuma T. Nat Commun. 2025 Mar 10;16(1):2365. doi: 10.1038/s41467-025-57539-6. PubMed |
| BET degraders reveal BRD4 disruption of 7SK and P-TEFb is critical for effective reactivation of latent HIV in CD4+ T-cells. Turner A-MW, Bashore FM, Falcinelli SD, Fox JA, Keller AL, Fenton AD, Geyer RF, Allard B, Kirchherr JL, Archin NM, James LI, Margolis DM. J Virol. 2025 Apr 15;99(4):e0177724. doi: 10.1128/jvi.01777-24. Epub 2025 Mar 11. PubMed |
| Epigenetic deprogramming by disruption of CIZ1-RNA nuclear assemblies in early-stage breast cancers. Turvey GL, Lopez de Alba E, Stewart E, Cook H, Alalti A, Gawne RT, Ainscough JF, Mason AS, Coverley D. J Cell Biol. 2025 May 5;224(5):e202409123. doi: 10.1083/jcb.202409123. Epub 2025 Mar 11. PubMed |
| Protocol for the simultaneous activation and lentiviral transduction of primary human T cells with artificial T cell receptors. Tan JYM, Tan JC, Wang C, Wu L, Gascoigne NRJ, Bhatt S. STAR Protoc. 2025 Mar 21;6(1):103685. doi: 10.1016/j.xpro.2025.103685. Epub 2025 Mar 10. PubMed |
| miR-204-5p Protects Nephrin from Enzymatic Degradation in Cultured Mouse Podocytes Treated with Nephrotoxic Serum. Haddad G, Blaine J. Cells. 2025 Mar 1;14(5):364. doi: 10.3390/cells14050364. PubMed |
| Collaborative role of two distinct cilium-specific cytoskeletal systems in driving Hedgehog-responsive transcription factor trafficking. Ku PI, Sreeja JS, Chadha A, Williams DS, Engelke MF, Subramanian R. Sci Adv. 2025 Mar 14;11(11):eadt5439. doi: 10.1126/sciadv.adt5439. Epub 2025 Mar 12. PubMed |
| Splenic red pulp macrophages eliminate the liver-resistant Streptococcus pneumoniae from the blood circulation of mice. An H, Huang Y, Zhao Z, Li K, Meng J, Huang X, Tian X, Zhou H, Wu J, Dai Q, Zhang JR. Sci Adv. 2025 Mar 14;11(11):eadq6399. doi: 10.1126/sciadv.adq6399. Epub 2025 Mar 12. PubMed |
| Lipoylation inhibition enhances radiation control of lung cancer by suppressing homologous recombination DNA damage repair. Chiang JC, Shang Z, Rosales T, Cai L, Chen WM, Cai F, Vu H, Minna JD, Ni M, Davis AJ, Timmerman RD, DeBerardinis RJ, Zhang Y. Sci Adv. 2025 Mar 14;11(11):eadt1241. doi: 10.1126/sciadv.adt1241. Epub 2025 Mar 12. PubMed |
| Targeting USP8 causes synthetic lethality through degradation of FGFR2 in ARID1A-deficient ovarian clear cell carcinoma. Saito R, Fukushima M, Sasaki M, Okamoto A, Ogiwara H. NPJ Precis Oncol. 2025 Mar 12;9(1):69. doi: 10.1038/s41698-025-00850-8. PubMed |
| MYC ecDNA promotes intratumour heterogeneity and plasticity in PDAC. Fiorini E, Malinova A, Schreyer D, Pasini D, Bevere M, Alessio G, Rosa D, D'Agosto S, Azzolin L, Milite S, Andreani S, Lupo F, Veghini L, Grimaldi S, Pedron S, Castellucci M, Nourse C, Salvia R, Malleo G, Ruzzenente A, Guglielmi A, Milella M, Lawlor RT, Luchini C, Agostini A, Carbone C, Pilarsky C, Sottoriva A, Scarpa A, Tuveson DA, Bailey P, Corbo V. Nature. 2025 Apr;640(8059):811-820. doi: 10.1038/s41586-025-08721-9. Epub 2025 Mar 12. PubMed |
| Crip2 affects vascular development by fine-tuning endothelial cell aggregation and proliferation. Yang S, Zhang X, Li X, Li H. Cell Mol Life Sci. 2025 Mar 13;82(1):110. doi: 10.1007/s00018-025-05624-w. PubMed |
| CXCR4 Inhibition Enhances the Efficacy of CD19 Monoclonal Antibody-Mediated Extermination of B-Cell Lymphoma. Khunti N, Kumar M, Datta M, Harelimana JD, Harms M, Albers D, Kirchhoff F, Munch J, Stenger S, Buske C, Maity PC. Int J Mol Sci. 2025 Feb 26;26(5):2024. doi: 10.3390/ijms26052024. PubMed |
| The Selective 3-MST Inhibitor I3MT-3 Works as a Potent Caspase-1 Inhibitor. Otani K, Komatsu R, Noguchi T, Suzuki W, Hirata Y, Matsuzawa A. Int J Mol Sci. 2025 Mar 2;26(5):2237. doi: 10.3390/ijms26052237. PubMed |
| Combined Therapy Targeting MET and Pro-HGF Activation Shows Significant Therapeutic Effect Against Liver Metastasis of CRPC. Kimura S, Iwano S, Akioka T, Kuchimaru T, Kawaguchi M, Fukushima T, Sato Y, Kataoka H, Kamoto T, Mukai S, Sawada A. Int J Mol Sci. 2025 Mar 5;26(5):2308. doi: 10.3390/ijms26052308. PubMed |
| Comprehensive genomic dependency landscape of a human colon cancer organoid. Khalili S, Mohseninia A, Liu C, Banister CE, Heine P, Khazan M, Morrison SE, Gokare P, Cowley GS, Weir BA, Pocalyko D, Bachman KE, Buckhaults PJ. Commun Biol. 2025 Mar 14;8(1):436. doi: 10.1038/s42003-025-07822-5. PubMed |
| Genome-wide screening in human embryonic stem cells identifies genes and pathways involved in the p53 pathway. Haddad A, Golan-Lev T, Benvenisty N, Goldberg M. Mol Med. 2025 Mar 13;31(1):97. doi: 10.1186/s10020-025-01141-5. PubMed |
| Enhanced therapeutic efficacy of anti-PD-1 blockade by targeting LAMP2A inhibits lysosomal degradation of STING and TBK1. Wang X, Zhang D, Xiao J, Wang L, Wang J, Cui X, Tan J, Liu Y, Miao S. Theranostics. 2025 Feb 18;15(7):3207-3222. doi: 10.7150/thno.103426. eCollection 2025. PubMed |
| Targeting platinum-resistant ovarian cancer by disrupting histone and RAD51 lactylation. Sun C, Li X, Teng Q, Liu X, Song L, Schioth HB, Wu H, Ma X, Zhang Z, Qi C, Zhang H, Song K, Zhang Q, Kong B. Theranostics. 2025 Feb 10;15(7):3055-3075. doi: 10.7150/thno.104858. eCollection 2025. PubMed |
| Glioblastoma progression is hindered by melatonin-primed mesenchymal stromal cells through dynamic intracellular and extracellular reorganizations. Olmedo-Moreno L, Panadero-Moron C, Sierra-Parraga JM, Bueno-Fernandez R, Norton ES, Aguilera Y, Mellado-Damas N, Garcia-Tarraga P, Morales-Gallel R, Antequera-Martinez M, Duran RV, Ferrer-Lozano J, Escames G, Garcia-Verdugo JM, Martin-Montalvo A, Guerrero-Cazares H, Capilla-Gonzalez V. Theranostics. 2025 Feb 10;15(7):3076-3097. doi: 10.7150/thno.104143. eCollection 2025. PubMed |
| A microglia clonal inflammatory disorder in Alzheimer's disease. Vicario R, Fragkogianni S, Weber L, Lazarov T, Hu Y, Hayashi SY, Craddock B, Socci ND, Alberdi A, Baako A, Ay O, Ogishi M, Lopez-Rodrigo E, Kappagantula R, Viale A, Iacobuzio-Donahue CA, Zhou T, Ransohoff RM, Chesworth R, Abdel-Wahab O, Boisson B, Elemento O, Casanova JL, Miller WT, Geissmann F. Elife. 2025 Mar 14;13:RP96519. doi: 10.7554/eLife.96519. PubMed |
| The E3 ubiquitin ligase RNF126 facilitates quality control of unimported mitochondrial membrane proteins. Liu D, Huo XY, Zhang X, Zhang ZR. J Biol Chem. 2025 Apr;301(4):108403. doi: 10.1016/j.jbc.2025.108403. Epub 2025 Mar 12. PubMed |
| USP7 V517F mutation as a mechanism of inhibitor resistance. Miao YL, Fan F, Cheng YJ, Jia L, Song SS, Huan XJ, Bao XB, Ding J, Yu X, He JX. Nat Commun. 2025 Mar 14;16(1):2526. doi: 10.1038/s41467-025-56981-w. PubMed |
| NLRP4 unlocks an NK/macrophages-centered ecosystem to suppress non-small cell lung cancer. Meng Z, Li J, Wang H, Cao Z, Lu W, Niu X, Yang Y, Li Z, Wang Y, Lu S. Biomark Res. 2025 Mar 14;13(1):44. doi: 10.1186/s40364-025-00756-4. PubMed |
| VIPAS39 confers ferroptosis resistance in epithelial ovarian cancer through exporting ACSL4. Jiang Y, Li J, Wang T, Gu X, Li X, Liu Z, Yue W, Li M. EBioMedicine. 2025 Apr;114:105646. doi: 10.1016/j.ebiom.2025.105646. Epub 2025 Mar 14. PubMed |
| Crohn's Disease-associated variant in laccase domain containing 1 (LACC1) modulates T cell gene expression, metabolism and T cell function. Li Y, Ascui G, Dicker M, Riffelmacher T, Chandra V, Schmiedel B, Chou TF, Vijayanand P, Kronenberg M. Nat Commun. 2025 Mar 15;16(1):2577. doi: 10.1038/s41467-025-57744-3. PubMed |
| Ubiquinol-mediated suppression of mitochondria-associated ferroptosis is a targetable function of lactate dehydrogenase B in cancer. Deng H, Zhao L, Ge H, Gao Y, Fu Y, Lin Y, Masoodi M, Losmanova T, Medova M, Ott J, Su M, Wang W, Peng RW, Dorn P, Marti TM. Nat Commun. 2025 Mar 16;16(1):2597. doi: 10.1038/s41467-025-57906-3. PubMed |
| Correlative In Situ Cryo-ET Reveals Cellular and Viral Remodeling Associated with Selective HIV-1 Core Nuclear Import. Hou Z, Shen Y, Fronik S, Shen J, Shi J, Xu J, Chen L, Hardenbrook N, Thompson C, Neumann S, Engelman AN, Aiken C, Zhang P. bioRxiv [Preprint]. 2025 Mar 4:2025.03.04.641496. doi: 10.1101/2025.03.04.641496. PubMed |
| The costimulatory domain influences CD19 CAR-T cell resistance development in B-cell malignancies. Krawczyk M, Fernandez-Fuentes N, Fidyt K, Winiarski T, Pepek M, Graczyk-Jarzynka A, Davis J, Bousquets-Munoz P, Puente XS, Menendez P, Benard E, Walchli S, Thomas-Tikhonenko A, Winiarska M. bioRxiv [Preprint]. 2025 Mar 4:2025.02.28.640707. doi: 10.1101/2025.02.28.640707. PubMed |
| A comprehensive map of missense trafficking variants in rhodopsin and their response to pharmacologic correction. Manian KV, Ludwig CH, Zhao Y, Abell N, Yang X, Root DE, Albert ML, Comander J. bioRxiv [Preprint]. 2025 Mar 4:2025.02.27.640335. doi: 10.1101/2025.02.27.640335. PubMed |
| CRISPR screening reveals ZNF217 as a vulnerability in high-risk B-cell acute lymphoblastic leukemia. Qin X, Zhou K, Dong L, Yang L, Li W, Chen Z, Shen C, Han L, Li Y, Chan AKN, Pokharel SP, Qing Y, Chen M, Wang K, Leung K, Sau L, Chen CW, Deng X, Su R, Chen J. Theranostics. 2025 Feb 18;15(8):3234-3256. doi: 10.7150/thno.100295. eCollection 2025. PubMed |
| Ubiquitination of gasdermin D N-terminal domain directs its membrane translocation and pore formation during pyroptosis. Chu X, Zhang T, Bukhari I, Hu M, Xu J, Xing Y, Liang X, Zhang Z, Zheng P. Cell Death Dis. 2025 Mar 17;16(1):181. doi: 10.1038/s41419-025-07475-6. PubMed |
| A CPC-shelterin-BTR axis regulates mitotic telomere deprotection. Romero-Zamora D, Rogers S, Low RRJ, Page SG, Lane BJE, Kosaka S, Robinson AB, French L, Lamm N, Ishikawa F, Hayashi MT, Cesare AJ. Nat Commun. 2025 Mar 17;16(1):2277. doi: 10.1038/s41467-025-57456-8. PubMed |
| Trans-Golgi network tethering factors regulate TBK1 trafficking and promote the STING-IFN-I pathway. Wang J, Niu S, Hu X, Li T, Liu S, Tu Y, Shang Z, Zhao L, Xu P, Lin J, Chen L, Billadeau DD, Jia D. Cell Discov. 2025 Mar 18;11(1):23. doi: 10.1038/s41421-024-00763-z. PubMed |
| Spatial control of m(6)A deposition on enhancer and promoter RNAs through co-acetylation of METTL3 and H3K27 on chromatin. Huang X, Zhang J, Cun Y, Ye M, Ren Z, Guo W, Ma X, Liu J, Luo W, Sun X, Shao J, Wu Z, Zhu X, Wang J. Mol Cell. 2025 Apr 3;85(7):1349-1365.e10. doi: 10.1016/j.molcel.2025.02.016. Epub 2025 Mar 17. PubMed |
| Guanine nucleotide biosynthesis blockade impairs MLL complex formation and sensitizes leukemias to menin inhibition. Shi X, Li M, Liu Z, Tiessen J, Li Y, Zhou J, Zhu Y, Mahesula S, Ding Q, Tan L, Feng M, Kageyama Y, Hara Y, Tao JJ, Luo X, Patras KA, Lorenzi PL, Huang S, Stevens AM, Takahashi K, Issa GC, Samee MAH, Agathocleous M, Nakada D. Nat Commun. 2025 Mar 18;16(1):2641. doi: 10.1038/s41467-025-57544-9. PubMed |
| POT, an optogenetics-based endogenous protein degradation system. Chen Y, Wang S, Zhang L, Peng D, Huang K, Ji B, Fu J, Xu Y. Commun Biol. 2025 Mar 18;8(1):455. doi: 10.1038/s42003-025-07919-x. PubMed |
| RNA-binding protein SAMD4A targets FGF2 to regulate cardiomyocyte lineage specification from human embryonic stem cells. Yi N, Wang HR, Zhu YP, Xiao T, Lin Q, Liu H, Meng YL, Sun YZ, Lin F, Hu SY, Cao HM, Zhang JF, Peng LY, Li L. Stem Cell Res Ther. 2025 Mar 18;16(1):144. doi: 10.1186/s13287-025-04269-7. PubMed |
| Overlapping and distinct functions of SPT6, PNUTS, and PCF11 in regulating transcription termination. Bejjani F, Segeral E, Mosca K, Lecourieux A, Bakail M, Hamoudi M, Emiliani S. Nucleic Acids Res. 2025 Feb 27;53(5):gkaf179. doi: 10.1093/nar/gkaf179. PubMed |
| LncRNA APTR amplification serves as a potential glioma biomarker and promotes glioma progression via miR-6734-5p/ TCF7/LEF1 axis. Chen H, Huang M, Li J, Zhang S, Sun C, Luo W, Yu L. Noncoding RNA Res. 2025 Feb 22;12:42-55. doi: 10.1016/j.ncrna.2025.02.007. eCollection 2025 Jun. PubMed |
| Tumor Cell-Expressed Herpesvirus Entry Mediator Regulates Proliferation and Adaptive Immunity in Ovarian Cancer. Lu Y, Zhang Y, Li W, Jiang H, Wang J, Guo X. Immun Inflamm Dis. 2025 Mar;13(3):e70175. doi: 10.1002/iid3.70175. PubMed |
| Genome-wide CRISPR screen identifies IRF1 and TFAP4 as transcriptional regulators of Galectin-9 in T cell acute lymphoblastic leukemia. Wiggers CRM, Yuzuguldu B, Tadros NG, Heavican-Foral TB, Cho EY, Eisenbies ZC, Ozdemir M, Kulp SB, Chae YC, Gutierrez A, Lohr JG, Knoechel B. Sci Adv. 2025 Mar 21;11(12):eads8351. doi: 10.1126/sciadv.ads8351. Epub 2025 Mar 19. PubMed |
| Bioengineering the metabolic network of CAR T cells with GLP-1 and Urolithin A increases persistence and long-term anti-tumor activity. Akhtar A, Shakir M, Ansari MS, Divya, Faizan MI, Chauhan V, Singh A, Alam R, Azmi I, Sharma S, Pracha M, Uddin IM, Bashir U, Shahni SN, Chaudhuri R, Albogami S, Ganguly R, Sagar S, Singh VP, Kharya G, Srivastava AK, Mabalirajan U, Roy SS, Rahman I, Ahmad T. Cell Rep Med. 2025 Mar 18;6(3):102021. doi: 10.1016/j.xcrm.2025.102021. PubMed |
| VDAC2 loss elicits tumour destruction and inflammation for cancer therapy. Yuan S, Sun R, Shi H, Chapman NM, Hu H, Guy C, Rankin S, Kc A, Palacios G, Meng X, Sun X, Zhou P, Yang X, Gottschalk S, Chi H. Nature. 2025 Apr;640(8060):1062-1071. doi: 10.1038/s41586-025-08732-6. Epub 2025 Mar 19. PubMed |
| Enhancement of functional insulin-producing cell differentiation from embryonic stem cells through MST1-silencing. Song H, Li J, Yang H, Kong B, Xu Y, Li X, Li H. Diabetol Metab Syndr. 2025 Mar 20;17(1):93. doi: 10.1186/s13098-025-01666-z. PubMed |
| Next Generation Aqueous Two-Phase System for Gentle, Effective, and Timely Extracellular Vesicle Isolation and Transcriptomic Analysis. Su B, Jeyhani M, Thillainadesan G, Sheng M, Wunsche R, Dayarathna T, Cimolai K, Weng H, Jerzak KJ, Liu SK, Tsai SSH, Leong HS. J Extracell Vesicles. 2025 Mar;14(3):e70058. doi: 10.1002/jev2.70058. PubMed |
| Elevated VRK1 levels after androgen deprivation therapy promote prostate cancer progression by upregulating YAP1 expression. Meng Y, Ge J, Zhou C, Ma H, Chen C, Zhou Y, Hu X, Xu Y, Wang X, Shi G, Yu W, Zhang J. J Cancer Res Clin Oncol. 2025 Mar 20;151(3):116. doi: 10.1007/s00432-025-06168-z. PubMed |
| Targeting COPA to Enhance Erdafitinib Sensitivity in FGFR-Altered Bladder Cancer. Zhao H, Gao X, Jiang Y, Yu Y, Wang L, Sun J, Wang M, Xiong X, Huang C, Zhang H, Jiang G. Adv Sci (Weinh). 2025 May;12(18):e2413209. doi: 10.1002/advs.202413209. Epub 2025 Mar 20. PubMed |
| Pyruvate metabolism enzyme DLAT promotes tumorigenesis by suppressing leucine catabolism. Wang N, Lu S, Cao Z, Li H, Xu J, Zhou Q, Yin H, Qian Q, Zhang X, Tao M, Jiang Q, Zhou P, Zheng L, Han L, Li H, Yin L, Gu Y, Dou X, Sun H, Wang W, Piao HL, Li F, Xu Y, Yang W, Chen S, Liu J. Cell Metab. 2025 Jun 3;37(6):1381-1399.e9. doi: 10.1016/j.cmet.2025.02.008. Epub 2025 Mar 19. PubMed |
| Targeting PI3K inhibitor resistance in breast cancer with metabolic drugs. Gremke N, Besong I, Stroh A, von Wichert L, Witt M, Elmshauser S, Wanzel M, Fromm MF, Taudte RV, Schmatloch S, Karn T, Reinisch M, Hirmas N, Loibl S, Wundisch T, Litmeyer AS, Jank P, Denkert C, Griewing S, Wagner U, Stiewe T. Signal Transduct Target Ther. 2025 Mar 21;10(1):92. doi: 10.1038/s41392-025-02180-4. PubMed |
| Light-induced expression of gRNA allows for optogenetic gene editing of T lymphocytes in vivo. Pulgarin DV, Pelo N, Ferrandiz L, Trselic T, Nyberg WA, Bowlin G, Espinosa A. Nucleic Acids Res. 2025 Mar 20;53(6):gkaf213. doi: 10.1093/nar/gkaf213. PubMed |
| TRIP13 protects pancreatic cancer cells against intrinsic and therapy-induced DNA replication stress. Anand JR, Droby GN, Joseph S, Patel U, Zhang X, Klomp JA, Der CJ, Purvis JE, Wolff SC, Bowser JL, Vaziri C. NAR Cancer. 2025 Mar 20;7(1):zcaf009. doi: 10.1093/narcan/zcaf009. eCollection 2025 Mar. PubMed |
| Bioinformatics Identification of Lactate-Associated Genes in Hepatocellular Carcinoma: G6PD's Role in Immune Modulation. Qu HR, Wang CQ, Sun SJ, Zhang WW, Liu CH, Du XS, Shu YY, Wang XC, Pan Q, Luo FL, Wu HY, Zhang XL, Liu M. Cancer Med. 2025 Mar;14(6):e70801. doi: 10.1002/cam4.70801. PubMed |
| Small-molecule RNA therapeutics to target prostate cancer. Kuzuoglu-Ozturk D, Nguyen HG, Xue L, Figueredo E, Subramanyam V, Liu I, Bonitto K, Noronha A, Dabrowska A, Cowan JE, Oses-Prieto JA, Burlingame AL, Worland ST, Carroll PR, Ruggero D. Cancer Cell. 2025 May 12;43(5):841-855.e8. doi: 10.1016/j.ccell.2025.02.027. Epub 2025 Mar 20. PubMed |
| Dicer deficiency affects microglial function during demyelination and impairs remyelination. Tripathi A, Rai NK, Perles A, Courtney H, Jones C, Sapra A, Plemel J, Dutta R. Neurobiol Dis. 2025 May;208:106879. doi: 10.1016/j.nbd.2025.106879. Epub 2025 Mar 20. PubMed |
| LL37 complexed to double-stranded RNA induces RIG-I-like receptor signalling and Gasdermin E activation facilitating IL-36gamma release from keratinocytes. Keller J, Danis J, Krehl I, Girousi E, Satoh TK, Meier-Schiesser B, Kemeny L, Szell M, Wong WW, Pascolo S, French LE, Kundig TM, Mellett M. Cell Death Dis. 2025 Mar 22;16(1):198. doi: 10.1038/s41419-025-07537-9. PubMed |
| Single-cell sequencing combined with urinary multi-omics analysis reveals that the non-invasive biomarker PRDX5 regulates bladder cancer progression through ferroptosis signaling. Wan S, Li KP, Chen SY, Wang CY, Cheng K, Yang JW, Ding LY, Che TJ, Liu SH, Yang L. BMC Cancer. 2025 Mar 24;25(1):533. doi: 10.1186/s12885-025-13881-y. PubMed |
| Dual CARM1-and IKZF3-targeting: A novel approach to multiple myeloma therapy synergy between CARM1 inhibition and IMiDs. Ni W, Garg S, Chowdhury B, Sattler M, Sanchez D, Meng C, Akatsu T, Donovan KA, Qi J, Wang MY, Starnbach CA, Liu X, Guzman MT, Teh WP, Stone R, Griffin JD, Buhrlage S, Weisberg E. Mol Ther Oncol. 2025 Feb 20;33(1):200952. doi: 10.1016/j.omton.2025.200952. eCollection 2025 Mar 20. PubMed |
| A large-scale sORF screen identifies putative microproteins involved in cancer cell fitness. Schlesinger D, Dirks C, Navarro C, Lafranchi L, Spinner A, Raja GL, Mun-Sum Tong G, Eirich J, Martinez TF, Elsasser SJ. iScience. 2025 Jan 23;28(3):111884. doi: 10.1016/j.isci.2025.111884. eCollection 2025 Mar 21. PubMed |
| ORMDL3 restrains type I interferon signaling and anti-tumor immunity by promoting RIG-I degradation. Zeng Q, Yao C, Zhang S, Mao Y, Wang J, Wang Z, Sheng C, Chen S. Elife. 2025 Mar 24;13:RP101973. doi: 10.7554/eLife.101973. PubMed |
PI(3,4,5)P3-mediated Cdc42 activation regulates macrophage podosome assembly.
Qi Y, Yu CH.
Cell Mol Life Sci. 2025 Mar 24;82(1):127. doi: 10.1007/s00018-025-05664-2.
PubMed
Associated Plasmids |
| Human long noncoding RNA VILMIR is induced by major respiratory viral infections and modulates the host interferon response. John K, Huntress I, Smith E, Chou H, Tollison TS, Covarrubias S, Crisci E, Carpenter S, Peng X. J Virol. 2025 Apr 15;99(4):e0014125. doi: 10.1128/jvi.00141-25. Epub 2025 Mar 25. PubMed |
| Targeting legumain-mediated cell-cell interaction sensitizes glioblastoma to immunotherapy in preclinical models. Pang L, Guo S, Huang Y, Khan F, Liu Y, Zhou F, Lathia JD, Chen P. J Clin Invest. 2025 Mar 25;135(10):e186034. doi: 10.1172/JCI186034. eCollection 2025 May 15. PubMed |
| SOD2 is a regulator of proteasomal degradation promoting an adaptive cellular starvation response. Ibrahim NK, Schreek S, Cinar B, Stasche AS, Lee SH, Zeug A, Dolgner T, Niessen J, Ponimaskin E, Shcherbata H, Fehlhaber B, Bourquin JP, Bornhauser B, Stanulla M, Pich A, Gutierrez A, Hinze L. Cell Rep. 2025 Apr 22;44(4):115434. doi: 10.1016/j.celrep.2025.115434. Epub 2025 Mar 24. PubMed |
| PI3Kbeta functions as a protein kinase to promote cellular protein O-GlcNAcylation and acetyl-CoA production for tumor growth. He X, Chen D, Liu G, Wu Q, Zhao H, Guo D, Jiang X, Li M, Meng Y, Yin Y, Ye X, Luo S, Xia Y, Hunter T, Lu Z. Mol Cell. 2025 Apr 3;85(7):1411-1425.e8. doi: 10.1016/j.molcel.2025.02.024. Epub 2025 Mar 24. PubMed |
| The ER-phagy receptor FAM134B is targeted by Salmonella Typhimurium to promote infection. Gatica D, Alsaadi RM, El Hamra R, Li B, Mueller R, Miyazaki M, Sun Q, Sad S, Russell RC. Nat Commun. 2025 Mar 25;16(1):2923. doi: 10.1038/s41467-025-58035-7. PubMed |
| FOXM1 expression reverts aging chromatin profiles through repression of the senescence-associated pioneer factor AP-1. Ferreira FJ, Galhardo M, Nogueira JM, Teixeira J, Logarinho E, Bessa J. Nat Commun. 2025 Mar 25;16(1):2931. doi: 10.1038/s41467-025-57503-4. PubMed |
| Identification of a SNAI1 enhancer RNA that drives cancer cell plasticity. Fan C, Wang Q, Krijger PHL, Cats D, Selle M, Khorosjutina O, Dhanjal S, Schmierer B, Mei H, de Laat W, Ten Dijke P. Nat Commun. 2025 Mar 25;16(1):2890. doi: 10.1038/s41467-025-58032-w. PubMed |
| The actin and microtubule network regulator WHAMM is identified as a key kidney disease risk gene. Mukhi D, Kolligundla LP, Doke T, Silva MA, Liu H, Palmer M, Susztak K. Cell Rep. 2025 Apr 22;44(4):115462. doi: 10.1016/j.celrep.2025.115462. Epub 2025 Mar 25. PubMed |
| Reelin marks cocaine-activated striatal neurons, promotes neuronal excitability, and regulates cocaine reward. Brida KL, Jorgensen ET, Robert A Phillips Iii, Newman CE, Tuscher JJ, Morring EK, Zipperly ME, Ianov L, Montgomery KD, Tippani M, Hyde TM, Maynard KR, Martinowich K, Day JJ. Sci Adv. 2025 Mar 28;11(13):eads4441. doi: 10.1126/sciadv.ads4441. Epub 2025 Mar 26. PubMed |
| The transcription factor MEF2C restrains microglial overactivation by inhibiting kinase CDK2. Hu X, Wu J, Shi L, Wang F, He K, Tan P, Hu Y, Yang Y, Wang D, Ma T, Ding S. Immunity. 2025 Apr 8;58(4):946-960.e10. doi: 10.1016/j.immuni.2025.02.026. Epub 2025 Mar 25. PubMed |
| Amplified dosage of the NKX2-1 lineage transcription factor controls its oncogenic role in lung adenocarcinoma. Pulice JL, Meyerson M. Mol Cell. 2025 Apr 3;85(7):1311-1329.e16. doi: 10.1016/j.molcel.2025.03.001. Epub 2025 Mar 25. PubMed |
| Multimodal SARS-CoV-2 interactome sketches the virus-host spatial organization. Dugied G, Laurent EM, Attia M, Gimeno JP, Bachiri K, Samavarchi-Tehrani P, Donati F, Rahou Y, Munier S, Amara F, Dos Santos M, Soler N, Volant S, Pietrosemoli N, Gingras AC, Pavlopoulos GA, van der Werf S, Falter-Braun P, Aloy P, Jacob Y, Komarova A, Sofianatos Y, Coyaud E, Demeret C. Commun Biol. 2025 Mar 26;8(1):501. doi: 10.1038/s42003-025-07933-z. PubMed |
| m(6)A modification regulates cell proliferation via reprogramming the balance between glycolysis and pentose phosphate pathway. Xi JF, Liu BD, Tang GR, Ren ZH, Chen HX, Lan YL, Yin F, Li Z, Cheng WS, Wang J, Chen L, Yuan SC, Zhang Z, Luo GZ. Commun Biol. 2025 Mar 26;8(1):496. doi: 10.1038/s42003-025-07937-9. PubMed |
| Glycosylation Regulation by TMEM230 in Aging and Autoimmunity. Piscitelli E, Abeni E, Balbino C, Angeli E, Cocola C, Pelucchi P, Palizban M, Diaspro A, Gotte M, Zucchi I, Reinbold RA. Int J Mol Sci. 2025 Mar 7;26(6):2412. doi: 10.3390/ijms26062412. PubMed |
| Interplay Between TGFbeta1 Signaling and Cancer-Testis Antigen MAGEB2: A New Thorn in Cancer's Side? Colemon A, Romney CV, Jones AD, Bagsby C, Jackson R, Ramanathan S. Int J Mol Sci. 2025 Mar 9;26(6):2448. doi: 10.3390/ijms26062448. PubMed |
| The Infectivity and Pathogenicity Characteristics of a Recombinant Porcine Epidemic Diarrhea Virus, CHFJFQ. Feng Z, Zhao H, Li Z, Lin M, Huang W, Liu C, Shen Y, Chen Q. Viruses. 2025 Mar 12;17(3):401. doi: 10.3390/v17030401. PubMed |
| KPNA5 Suppresses Malignant Progression of Ovarian Cancer Through Importing the PTPN4 Into the Nucleus. Hu Y, Zhou J, Ling X, Zhao K, Huang P, Gao M, Li X, Sun M, Zou Y, Feng G. Cancer Med. 2025 Apr;14(7):e70731. doi: 10.1002/cam4.70731. PubMed |
| Eph Receptors Activate Myeloid Checkpoint Receptor LILRB5 to Support Tumor Development. He Y, Zhang C, Tan L, Deng M, Liu X, Huang R, Yang X, Xie J, Lou Q, Fang M, Smith C, John S, Xiong W, Li X, Lewis C, Homsi J, Gupta A, Zhang N, An Z, Zhang CC. Cancer Immunol Res. 2025 Jun 4;13(6):821-835. doi: 10.1158/2326-6066.CIR-24-0737. PubMed |
| Three-dimensional regulatory hubs support oncogenic programs in glioblastoma. Breves SL, Di Giammartino DC, Nicholson J, Cirigliano S, Mahmood SR, Lee UJ, Martinez-Fundichely A, Jungverdorben J, Singhania R, Rajkumar S, Kirou R, Studer L, Khurana E, Polyzos A, Fine HA, Apostolou E. Mol Cell. 2025 Apr 3;85(7):1330-1348.e6. doi: 10.1016/j.molcel.2025.03.007. Epub 2025 Mar 26. PubMed |
| Metabolic constraint of human telomere length by nucleotide salvage efficiency. Mannherz W, Crompton A, Lampl N, Agarwal S. Nat Commun. 2025 Mar 27;16(1):3000. doi: 10.1038/s41467-025-58221-7. PubMed |
| Praja2 controls P-body assembly and translation in glioblastoma by non-proteolytic ubiquitylation of DDX6. Senatore E, Avolio R, Rinaldi L, Chiuso F, Oliva MA, D'Ambrosio C, Bianco AG, Dalla E, Pagnotta SM, Flammia R, Ambrosino C, Memoli D, Turacchio G, Mimoune SI, Toiron Y, Audebert S, Camoin L, Lignitto L, Scaloni A, Arcella A, Feliciello A. EMBO Rep. 2025 May;26(9):2347-2377. doi: 10.1038/s44319-025-00425-5. Epub 2025 Mar 27. PubMed |
A stress-dependent TDP-43 SUMOylation program preserves neuronal function.
Suk TR, Part CE, Zhang JL, Nguyen TT, Heer MM, Caballero-Gomez A, Grybas VS, McKeever PM, Nguyen B, Ali T, Callaghan SM, Woulfe JM, Robertson J, Rousseaux MWC.
Mol Neurodegener. 2025 Mar 28;20(1):38. doi: 10.1186/s13024-025-00826-z.
PubMed
Associated Plasmids |
| Drosophila and human Headcase define a new family of ribonucleotide granule proteins required for stress response. Ricolo D, Casanova J, Giannios P. Sci Adv. 2025 Mar 28;11(13):eads2086. doi: 10.1126/sciadv.ads2086. Epub 2025 Mar 28. PubMed |
| YY1-induced transcription of AKR1C3 activates the Hedgehog signalling pathway to enhance lenalidomide resistance and glycolytic activity in multiple myeloma cells. Chen Y, Zhang A, Wang Y, Qi D, Peng C, Liang Z, Guo J, Gu Y. Clin Exp Med. 2025 Mar 29;25(1):99. doi: 10.1007/s10238-025-01619-w. PubMed |
| Single-cell multi-omics analysis reveals the mechanism of action of a novel antioxidant polyphenol nanoparticle loaded with STAT3 agonist in mediating cardiomyocyte ferroptosis to ameliorate age-related heart failure. Zheng H, Tian Y, Li D, Liang Y. J Nanobiotechnology. 2025 Mar 29;23(1):258. doi: 10.1186/s12951-025-03317-x. PubMed |
| Retinoic acid enhances gammadelta T cell cytotoxicity in nasopharyngeal carcinoma by reversing immune exhaustion. Liu G, Quan Q, Pan L, Duan H, Zhang G, Li K, Zhu X, Zhang D, Li P, Zhao J. Cell Commun Signal. 2025 Mar 29;23(1):156. doi: 10.1186/s12964-025-02161-8. PubMed |
| SWI/SNF complex-mediated ZNF410 cooperative binding maintains chromatin accessibility and enhancer activity. Xu S, Peng C, Ren R, Lu H, Zhao H, Xia S, Shen Y, Xu B, Zhang H, Cheng X, Blobel GA, Lan X. Cell Rep. 2025 Apr 22;44(4):115476. doi: 10.1016/j.celrep.2025.115476. Epub 2025 Mar 28. PubMed |
| NEDD4 E3 ligase-catalyzed NAMPT ubiquitination and autophagy activation are essential for pyroptosis-independent NAMPT secretion in human monocytes. Rodriguez M, Xu H, Hernandez A, Ingraham J, Canizales J, Arce FT, Camp SM, Briggs S, Ooi A, Burke JM, Song JH, Garcia JGN. Cell Commun Signal. 2025 Mar 30;23(1):157. doi: 10.1186/s12964-025-02164-5. PubMed |
| CREB-family transcription factors and vasopressin-mediated regulation of Aqp2 gene transcription. Murillo-de-Ozores AR, Chen L, Ou SM, Park E, Khan S, Raghuram V, Yang CR, Chou CL, Knepper MA. bioRxiv [Preprint]. 2025 Mar 13:2025.03.10.642395. doi: 10.1101/2025.03.10.642395. PubMed |
| IL-6 underlies microenvironment immunosuppression and resistance to therapy in glioblastoma. Young JS, Cho NW, Lucas CG, Najem H, Mirchia K, Chen WC, Seo K, Zakimi N, Daggubati V, Casey-Clyde T, Nguyen MP, Chen A, Phillips JJ, Ozawa T, Aghi MK, Taylor JW, DeRisi JL, Bhaduri A, Berger MS, Heimberger AB, Butowski N, Spitzer MH, Raleigh DR. bioRxiv [Preprint]. 2025 Mar 14:2025.03.12.642800. doi: 10.1101/2025.03.12.642800. PubMed |
| Delta-catenin is required for cell proliferation in virus positive Merkel cell carcinoma cell lines but not in human fibroblasts. Vinueza JL, Salisbury NJH, Dye KN, Roman A, Galloway DA. bioRxiv [Preprint]. 2025 Mar 14:2025.03.12.642815. doi: 10.1101/2025.03.12.642815. PubMed |
| Microenvironmental arginine restriction sensitizes pancreatic cancers to polyunsaturated fatty acids by suppression of lipid synthesis. Jonker PB, Sadullozoda M, Cognet G, Saab JJA, Sokol KH, Wu VX, Kumari D, Sheehan C, Ozgurses ME, Agovino D, Croley G, Patel SA, Bock-Hughes A, Macleod KF, Shah H, Coloff JL, Lien EC, Muir A. bioRxiv [Preprint]. 2025 Mar 13:2025.03.10.642426. doi: 10.1101/2025.03.10.642426. PubMed |
| HTLV-1 Tax induces PINK1-Parkin-dependent mitophagy to mitigate activation of the cGAS-STING pathway. Mohanty S, Suklabaidya S, Mnatsakanyan N, Jacobson S, Harhaj EW. bioRxiv [Preprint]. 2025 Mar 15:2025.03.15.643451. doi: 10.1101/2025.03.15.643451. PubMed |
| The Prolonged Half-Life of the p53 Missense Variant R248Q Promotes Accumulation and Heterotetramer Formation with Wild-Type p53 to Exert the Dominant-Negative Effect. Klemm N, Schimmer RR, Konrad NK, Thelen F, Fullin J, Topcu E, Koch C, Treacy M, Leventhal MJ, Buhler MM, Lysenko V, Theocharides APA, Kurppa KJ, Balabanov S, Baubec T, Krivtsov AV, Miller PG, Armstrong SA, Ebert BL, Manz MG, Nombela-Arrieta C, Boettcher S. Cancer Res. 2025 Jun 2;85(11):1978-1996. doi: 10.1158/0008-5472.CAN-24-1136. PubMed |
| SIRT5-mediated desuccinylation of PPA2 enhances HIF-1alpha-dependent adaptation to hypoxic stress and colorectal cancer metastasis. Zhang X, Di Y, Wang Y, Qin J, Ye L, Wen X, Ke Z, Wang Z, He W. EMBO J. 2025 May;44(9):2514-2540. doi: 10.1038/s44318-025-00416-1. Epub 2025 Mar 31. PubMed |
| C1Q(+) TPP1(+) macrophages promote colon cancer progression through SETD8-driven p53 methylation. Veschi V, Verona F, Di Bella S, Turdo A, Gaggianesi M, Di Franco S, Mangiapane LR, Modica C, Lo Iacono M, Bianca P, Brancato OR, D'Accardo C, Porcelli G, Lentini VL, Sperduti I, Sciacca E, Fitzgerald P, Lopez-Perez D, Martine P, Brown K, Giannini G, Appella E, Stassi G, Todaro M. Mol Cancer. 2025 Mar 31;24(1):102. doi: 10.1186/s12943-025-02293-y. PubMed |
| CRISPR screens with trastuzumab emtansine in HER2-positive breast cancer cell lines reveal new insights into drug resistance. Lipert BA, Siemens KN, Khan A, Airey R, Dam GH, Lu M, Flinterman M, Yong Q, Lee TW, Hunter FW, Jamieson SMF. Breast Cancer Res. 2025 Mar 31;27(1):48. doi: 10.1186/s13058-025-02000-1. PubMed |
| Antigenic cancer persister cells survive direct T cell attack. Wang MX, Mauch BE, Williams AF, Barazande-Pour T, Araujo Hoffmann F, Harris SH, Lathrop CP, Turkal CE, Yung BS, Paw MH, Gervasio DAG, Tran T, Stuhlfire AE, Guo T, Daniels GA, Park SJ, Gutkind JS, Hangauer MJ. bioRxiv [Preprint]. 2025 Mar 17:2025.03.14.643359. doi: 10.1101/2025.03.14.643359. PubMed |
| RAB5 is a host dependency factor for the generation of SARS-CoV-2 replication organelles. Chen Y, Klute S, Sparrer KMJ, Serra-Moreno R. mBio. 2025 May 14;16(5):e0331424. doi: 10.1128/mbio.03314-24. Epub 2025 Apr 1. PubMed |
| SLO2.1/NALCN Functional Complex Activity in Mouse Myometrial Smooth Muscle Cells During Pregnancy. Ferreira JJ, Kent LN, McCarthy R, Butler A, Ma X, Peramsetty N, Amazu C, Zhang A, Whitter GC, Li E, England SK, Santi CM. J Cell Physiol. 2025 Apr;240(4):e70024. doi: 10.1002/jcp.70024. PubMed |
| Papillomavirus-like particles as vectors for ex vivo gene therapy of the skin. Diversi F, Dabin J, Mazza E, Rinaldin M, de Castro Reis F, Hackett JA, Heppenstall PA. Mol Ther Nucleic Acids. 2025 Mar 5;36(2):102501. doi: 10.1016/j.omtn.2025.102501. eCollection 2025 Jun 10. PubMed |
| Siglec-15 is a putative receptor for porcine epidemic diarrhea virus infection. Feng Z, Fu Y, Yang S, Zhao H, Lin M, Liu C, Huang W, He X, Chen Y, Chen J, Shen Y, Li Z, Chen Q. Cell Mol Life Sci. 2025 Apr 2;82(1):136. doi: 10.1007/s00018-025-05672-2. PubMed |
| The MFN2 Q367H variant reveals a novel pathomechanism connected to mtDNA-mediated inflammation. Zaman M, Sharma G, Almutawa W, Soule TG, Sabouny R, Joel M, Mohan A, Chute C, Joseph JT, Pfeffer G, Shutt TE. Life Sci Alliance. 2025 Apr 2;8(6):e202402921. doi: 10.26508/lsa.202402921. Print 2025 Jun. PubMed |
| Covalent adduct Grob fragmentation underlies LSD1 demethylase-specific inhibitor mechanism of action and resistance. Waterbury AL, Caroli J, Zhang O, Tuttle PR, Liu C, Li J, Park JS, Hoenig SM, Barone M, Furui A, Mattevi A, Liau BB. Nat Commun. 2025 Apr 2;16(1):3156. doi: 10.1038/s41467-025-57477-3. PubMed |
| The impact of a high fat diet and platelet activation on pre-metastatic niche formation. Hergueta-Redondo M, Sanchez-Redondo S, Hurtado B, Santos V, Perez-Martinez M, Ximenez-Embun P, McDowell SAC, Mazariegos MS, Mata G, Torres-Ruiz R, Rodriguez-Perales S, Martinez L, Grana-Castro O, Megias D, Quail D, Quintela-Fandino M, Peinado H. Nat Commun. 2025 Apr 2;16(1):2897. doi: 10.1038/s41467-025-57938-9. PubMed |
| Genome-wide CRISPR screen identifies BUB1 kinase as a druggable vulnerability in malignant pleural mesothelioma. Cakiroglu E, Eris S, Oz O, Karakulah G, Senturk S. Cell Death Dis. 2025 Apr 3;16(1):241. doi: 10.1038/s41419-025-07587-z. PubMed |
| Advanced hydrogel mesh platform with neural stem cells and human umbilical vein endothelial cells for enhanced axonal regeneration. Kim JT, Han SW, Youn DH, Jung H, Lee EH, Kang SM, Cho YJ, Jeon JP. APL Bioeng. 2025 Apr 1;9(2):026101. doi: 10.1063/5.0244057. eCollection 2025 Jun. PubMed |
| RAF1 kinase contributes to autophagic lysosome reformation. Toifl S, Didusch S, Ehrenreiter K, Desideri E, Dorard C, Baccarini M. Cell Rep. 2025 Apr 22;44(4):115490. doi: 10.1016/j.celrep.2025.115490. Epub 2025 Apr 3. PubMed |
| Changes in adrenoceptor expression level contribute to the cellular plasticity of glioblastoma cells. Asaka Y, Masumoto T, Uneda A, Chin VD, Otani Y, Pena T, Katayama H, Itano T, Ando T, Huang R, Fujimura A. J Physiol Sci. 2025 Mar 28;75(2):100016. doi: 10.1016/j.jphyss.2025.100016. PubMed |
| G0S2 modulates normal vitreous-induced proliferation in endothelial cells. Yin Y, Pu L, Yang X, Zhu Y, Chen F, Wu C, Lei H, Wu W. Commun Biol. 2025 Apr 4;8(1):560. doi: 10.1038/s42003-025-07955-7. PubMed |
| Heritable maintenance of chromatin modifications confers transcriptional memory of interferon-gamma signaling. Mikulski P, Tehrani SSH, Kogan A, Abdul-Zani I, Shell E, James L, Ryan BJ, Jansen LET. Nat Struct Mol Biol. 2025 Apr 4. doi: 10.1038/s41594-025-01522-8. PubMed |
| PLK1 blockade enhances the anti-tumor effect of MAPK inhibition in pancreatic ductal adenocarcinoma. Zhao B, Fang R, Schurmann H, Hemmer EJ, Mayer GL, Trajkovic-Arsic M, Althoff K, Yang J, Godfrey L, Liffers ST, Savvatakis K, Dorsch M, Gruner BM, Hahn S, Remke M, Lueong SS, Siveke JT. Cell Rep. 2025 Apr 22;44(4):115541. doi: 10.1016/j.celrep.2025.115541. Epub 2025 Apr 5. PubMed |
| CDX2 downregulation regulates intrinsic WNT pathway activation, dictating metastasis in APC and CTNNB1 wildtype colorectal cancer. Wouters VM, Helderman RFCPA, Cameron K, van der Hooff SR, Torang A, van den Bergh S, Jackstadt R, Sansom OJ, van Neerven SM, Medema JP. Oncogene. 2025 Jul;44(25):2091-2102. doi: 10.1038/s41388-025-03365-5. Epub 2025 Apr 6. PubMed |
| A targeted CRISPR screen identifies ETS1 as a regulator of HIV-1 latency. Ashokkumar M, Hafer TL, Felton A, Archin NM, Margolis DM, Emerman M, Browne EP. PLoS Pathog. 2025 Apr 8;21(4):e1012467. doi: 10.1371/journal.ppat.1012467. eCollection 2025 Apr. PubMed |
| The evolution of AKAPs and emergence of PKA isotype selective anchoring determinants. Falcone JI, Cleveland KH, Kang M, Odle BJ, Forbush KA, Scott JD. J Biol Chem. 2025 May;301(5):108480. doi: 10.1016/j.jbc.2025.108480. Epub 2025 Apr 6. PubMed |
| Bisphenol S Exposure and MASLD: A Mechanistic Study in Mice. Li S, Fan Y, Tang M, Wu X, Bai S, Yang X, Zhang X, Lu C, Ji C, Wade PA, Wang X, Gu W, Du G, Qin Y. Environ Health Perspect. 2025 May;133(5):57009. doi: 10.1289/EHP17057. Epub 2025 May 14. PubMed |
EIF3D safeguards the homeostasis of key signaling pathways in human primed pluripotency.
Okubo C, Nakamura M, Sato M, Shichino Y, Mito M, Takashima Y, Iwasaki S, Takahashi K.
Sci Adv. 2025 Apr 11;11(15):eadq5484. doi: 10.1126/sciadv.adq5484. Epub 2025 Apr 9.
PubMed
Associated Plasmids |
| Cross-talks between Metabolic and Translational Controls during Beige Adipocyte Differentiation. Youn D, Kim B, Jeong D, Lee JY, Kim S, Sumberzul D, Ginting RP, Lee MW, Song JH, Park YS, Kim Y, Oh CM, Lee M, Cho J. Nat Commun. 2025 Apr 9;16(1):3373. doi: 10.1038/s41467-025-58665-x. PubMed |
| An unconventional autophagic pathway that inhibits ATP secretion during apoptotic cell death. Terraza-Silvestre E, Villamuera R, Bandera-Linero J, Letek M, Ona-Sanchez D, Ramon-Barros C, Moyano-Jimeno C, Pimentel-Muinos FX. Nat Commun. 2025 Apr 10;16(1):3409. doi: 10.1038/s41467-025-58619-3. PubMed |
| Genetic modulation of rare earth nanoparticle biotransformation shapes biological outcomes. Tian M, Wu D, Gou X, Li R, Zhang X. Nat Commun. 2025 Apr 11;16(1):3429. doi: 10.1038/s41467-025-58520-z. PubMed |
| Perturb-tracing enables high-content screening of multi-scale 3D genome regulators. Cheng Y, Hu M, Yang B, Jensen TB, Zhang Y, Yang T, Yu R, Ma Z, Radda JSD, Jin S, Zang C, Wang S. Nat Methods. 2025 May;22(5):950-961. doi: 10.1038/s41592-025-02652-z. Epub 2025 Apr 10. PubMed |
| Increased mGluR5 in somatostatin-positive interneurons mediates deactivation of the mPFC in a mouse model of neuropathic pain. Jang M, Lee J, Kim SH, Yoon SH, Kim MH, Lee YS, Kim SK, Chung G, Kim SJ. Exp Mol Med. 2025 Apr;57(4):888-899. doi: 10.1038/s12276-025-01435-y. Epub 2025 Apr 10. PubMed |
| Multipotent neural stem cells originating from neuroepithelium exist outside the mouse central nervous system. Han D, Xu W, Jeong HW, Park H, Weyer K, Tsytsyura Y, Stehling M, Wu G, Lan G, Kim KP, Renner H, Han DW, Chen Y, Gerovska D, Arauzo-Bravo MJ, Klingauf J, Schwamborn JC, Adams RH, Liu P, Scholer HR. Nat Cell Biol. 2025 Apr;27(4):605-618. doi: 10.1038/s41556-025-01641-w. Epub 2025 Apr 10. PubMed |
| MEIS1 knockdown upregulates WNT signaling pathway genes in esophageal squamous cell carcinoma. Hosseini N, Forghanifard MM. BMC Med Genomics. 2025 Apr 10;18(1):69. doi: 10.1186/s12920-025-02134-3. PubMed |
| CLEC12A-directed immunocytokine with target cell-restricted IL-15 activity for treatment of acute myeloid leukemia. Klimovich B, Anton L, Jung J, Lim Y, Lee B, Won J, Zekri L, Chashchina A, Pflugler M, Heitmann JS, Jung G, Salih HR. Front Immunol. 2025 Mar 27;16:1561823. doi: 10.3389/fimmu.2025.1561823. eCollection 2025. PubMed |
| Library-based single-cell analysis of CAR signaling reveals drivers of in vivo persistence. Perez CR, Garmilla A, Nilsson A, Baghdassarian HM, Gordon KS, Lima LG, Smith BE, Maus MV, Lauffenburger DA, Birnbaum ME. Cell Syst. 2025 May 21;16(5):101260. doi: 10.1016/j.cels.2025.101260. Epub 2025 Apr 10. PubMed |
| Endogenous protein S100A14 stabilizes glutaminase to render hepatocellular carcinoma resistant to sorafenib. Wang M, Li Y, Su J, Dong X, Liu A, Yang Y, Tang X, Chen R, Li Q, Wang H, Xiao H. J Transl Med. 2025 Apr 11;23(1):435. doi: 10.1186/s12967-025-06333-5. PubMed |
| A genome-wide screen identifies genes required for erythroid differentiation. Myers G, Friedman A, Yu L, Pourmandi N, Kerpet C, Ito MA, Saba R, Tang V, Ozel AB, Bergin IL, Johnson CN, Ku CJ, Wang Y, Balbin-Cuesta G, Lim KC, Lin Z, Drysdale C, McGee B, Kurita R, Nakamura Y, Liu X, Siemieniak D, Singh SA, Lyssiotis CA, Maillard I, Weisman LS, Engel JD, Khoriaty R. Nat Commun. 2025 Apr 12;16(1):3488. doi: 10.1038/s41467-025-58739-w. PubMed |
| SRPK1 Activation Facilitates Gli3(S664) Phosphorylation and Promotes Metastasis in Esophageal Squamous Cell Carcinoma. Ding Y, Qin J, Zhang M, Wu H, Liu C, Guo Y, Wu W, Jiang Y, Zhang C, Ma Y, Chen X, Lu J, Liu K, Dong Z, Zhao J, Qiao Y. Mol Carcinog. 2025 Jul;64(7):1168-1181. doi: 10.1002/mc.23913. Epub 2025 Apr 13. PubMed |
| The RBM39 degrader indisulam inhibits acute megakaryoblastic leukemia by altering the alternative splicing of ZMYND8. Yang Y, Li Z, Yang Y, Xiao P, He Z, Zhang Z, Li Y, Shi L, Wang X, Tao Y, Fan J, Zhang F, Yang C, Yao F, Ji T, Zhang Y, Zhou B, Yu J, Guo A, Wei Z, Jiao W, Wu Y, Li Y, Wu D, Wu Y, Gao L, Hu Y, Pan J, Hu S, Yang X. Cell Biosci. 2025 Apr 13;15(1):46. doi: 10.1186/s13578-025-01380-3. PubMed |
| RNF138 regulates skeletal muscle differentiation via the Wnt/beta-catenin signaling pathway. Wang W, Wang Z, Li R, Huang W, Ling Q, Li X, Li Z, Cao M, Zhang Z, Sun Q, Liang Z, Zhang HA, Jiang X, Lin C, Chen Y, Zhao B, Zhao Y, Pan JA, Peng X. Theranostics. 2025 Mar 18;15(10):4446-4464. doi: 10.7150/thno.110925. eCollection 2025. PubMed |
| ALDH1A3 Regulates Cellular Senescence and Senescence-Associated Secretome in Prostate Cancer. Wang S, Wang L, Zhao Y. Cancers (Basel). 2025 Mar 31;17(7):1184. doi: 10.3390/cancers17071184. PubMed |
| Programmable protein stabilization with language model-derived peptide guides. Hong L, Ye T, Wang TZ, Srijay D, Liu H, Zhao L, Watson R, Vincoff S, Chen T, Kholina K, Goel S, DeLisa MP, Chatterjee P. Nat Commun. 2025 Apr 15;16(1):3555. doi: 10.1038/s41467-025-58872-6. PubMed |
| Lysosomal lipid peroxidation contributes to ferroptosis induction via lysosomal membrane permeabilization. Saimoto Y, Kusakabe D, Morimoto K, Matsuoka Y, Kozakura E, Kato N, Tsunematsu K, Umeno T, Kiyotani T, Matsumoto S, Tsuji M, Hirayama T, Nagasawa H, Uchida K, Karasawa S, Jutanom M, Yamada KI. Nat Commun. 2025 Apr 15;16(1):3554. doi: 10.1038/s41467-025-58909-w. PubMed |
| N-Glycosylation Modification of Fzd4 Is Essential for the Fzd4-Wnt-beta-Catenin Signalling Axis. Ji T, Li X, Li J, Wang G. J Cell Mol Med. 2025 Apr;29(7):e70539. doi: 10.1111/jcmm.70539. PubMed |
| Pan-cancer analysis of CHRDL1 expression and its mechanistic role in inhibiting EMT via the TGF-beta pathway in lung adenocarcinoma. Dong H, Tian Y, Xin S, Guo Y, Jiang S, Wan Z, Wang H, Han Y. Front Cell Dev Biol. 2025 Mar 31;13:1557761. doi: 10.3389/fcell.2025.1557761. eCollection 2025. PubMed |
| Myogenic IGFBP5 levels in rhabdomyosarcoma are nourished by mesenchymal stromal cells and regulate growth arrest and apoptosis. Zhang Y, Katkhada K, Meng LZ, Zhao B, Tong S, Chaabane W, Kallai A, Tobin NP, Ostman A, Mega A, Ehnman M. Cell Commun Signal. 2025 Apr 15;23(1):184. doi: 10.1186/s12964-025-02171-6. PubMed |
| Single-guide RNA Cas9 and enhanced-deletion Cas9 rescue a recurrent USH2A-related splicing defect. De Angeli P, Spaag S, Shliaga S, Flores-Tufino A, Ritter M, Nasri M, Stingl K, Kuhlewein L, Wissinger B, Kohl S. Mol Ther Nucleic Acids. 2025 Mar 21;36(2):102523. doi: 10.1016/j.omtn.2025.102523. eCollection 2025 Jun 10. PubMed |
| Complete Loss of PAX4 causes Transient Neonatal Diabetes in Humans. Russ-Silsby J, Lee Y, Rajesh V, Amoli M, Mirhosseini NA, Godbole T, Johnson MB, Ibarra DE, Sun H, Krentz NAJ, Wakeling MN, Flanagan SE, Hattersley AT, Gloyn AL, De Franco E. medRxiv [Preprint]. 2025 Apr 3:2025.04.01.25324926. doi: 10.1101/2025.04.01.25324926. PubMed |
| Unraveling the Role of NeuroD2 in Ischemic Pathophysiology: Insight into Neuroprotection Mechanisms Associated with AKT Survival Kinase. Bolat B, Bayraktaroglu C, Degirmenci Z, Cerah E, Sali M, Kolcu E, Bars DN, Aydin C, Abasova F, Alisoy A, Atali HE, Beker MC, Celik U, Beker M. Neuromolecular Med. 2025 Apr 16;27(1):28. doi: 10.1007/s12017-025-08852-2. PubMed |
| Functional characterization of all CDKN2A missense variants and comparison to in silico models of pathogenicity. Kimura H, Lahouel K, Tomasetti C, Roberts NJ. Elife. 2025 Apr 16;13:RP95347. doi: 10.7554/eLife.95347. PubMed |
| Co-targeting BMI1 and MYC to eliminate cancer stem cells in squamous cell carcinoma. Qin Z, Liu S, Zheng Y, Wang Y, Chen Y, Peng X, Jia L. Cell Rep Med. 2025 May 20;6(5):102077. doi: 10.1016/j.xcrm.2025.102077. Epub 2025 Apr 15. PubMed |
| Loss of VHL-mediated pRb regulation promotes clear cell renal cell carcinoma. Akuma M, Kim M, Zhu C, Wiljer E, Gaudreau-Lapierre A, Patterson LD, Egevad L, Tanguay S, Trinkle-Mulcahy L, Stanford WL, Riazalhosseini Y, Russell RC. Cell Death Dis. 2025 Apr 16;16(1):307. doi: 10.1038/s41419-025-07623-y. PubMed |
| Elevated mitochondrial membrane potential is a therapeutic vulnerability in Dnmt3a-mutant clonal hematopoiesis. Young KA, Hosseini M, Mistry JJ, Morganti C, Mills TS, Cai X, James BT, Nye GJ, Fournier NR, Voisin V, Chegini A, Schimmer AD, Bader GD, Egan G, Mansour MR, Challen GA, Pietras EM, Fisher-Wellman KH, Ito K, Chan SM, Trowbridge JJ. Nat Commun. 2025 Apr 16;16(1):3306. doi: 10.1038/s41467-025-57238-2. PubMed |
| Comparative single-cell transcriptomic profiling of patient-derived renal carcinoma cells in cellular and animal models of kidney cancer. Huang R, Kee L, Gont A, Meens J, Ferens FG, Irwin MS, Ailles L, Yuzwa SA, Robinson CM, Ohh M. FEBS Open Bio. 2025 Apr 16. doi: 10.1002/2211-5463.70022. PubMed |
| The G protein-coupled receptor GPR89A is a novel potential therapeutic target to overcome cisplatin resistance in NSCLC Calu1 cells. Guler Kara H, Dogan E, Bozok V, Aktan C, Cakiroglu E, Eroglu Z, Aygunes Jafari D, Korkmaz KS, Senturk S, Kosova B. FEBS J. 2025 Jul;292(14):3755-3770. doi: 10.1111/febs.70099. Epub 2025 Apr 17. PubMed |
| Targeting the cuproptosis‑associated gene COL22A1 in glioblastoma using EMD‑1204831 and kaempferol. Chen Y, Zhang Y, Yang H, Liu Q, Sui R, Shi J, Liang H, Liu J, Xu H, Piao H. Int J Oncol. 2025 May;66(5):38. doi: 10.3892/ijo.2025.5744. Epub 2025 Apr 17. PubMed |
| MFRP is a molecular hub that organizes the apical membrane of RPE cells by engaging in interactions with specific proteins and lipids. Tworak A, Smidak R, Rodrigues Menezes C, Du SW, Suh S, Choi EH, Imanishi SS, Dong Z, Lewandowski D, Fong KE, Grigorean G, Pinto AFM, Xu Q, Skowronska-Krawczyk D, Blackshaw S, Imanishi Y, Palczewski K. Proc Natl Acad Sci U S A. 2025 Apr 22;122(16):e2425523122. doi: 10.1073/pnas.2425523122. Epub 2025 Apr 18. PubMed |
Genetically encoded tool for manipulation of DeltaPsim identifies its role as the driver of ISR induced by ATP synthase dysfunction.
Choe M, Ekvik AE, Stalnaker G, Shin HR, Titov DV.
Cell Chem Biol. 2025 Apr 17;32(4):620-630.e6. doi: 10.1016/j.chembiol.2025.03.007.
PubMed
Associated Plasmids |
| Circular RMST cooperates with lineage-driving transcription factors to govern neuroendocrine transdifferentiation. Teng M, Guo J, Xu X, Ci X, Mo Y, Kohen Y, Ni Z, Chen S, Guo WY, Bakht M, Ku S, Sigouros M, Luo W, Macarios CM, Xia Z, Chen M, Ul Haq S, Yang W, Berlin A, van der Kwast T, Ellis L, Zoubeidi A, Zheng G, Ming J, Wang Y, Cui H, Lok BH, Raught B, Beltran H, Qin J, He HH. Cancer Cell. 2025 May 12;43(5):891-904.e10. doi: 10.1016/j.ccell.2025.03.027. Epub 2025 Apr 17. PubMed |
| Temozolomide promotes glioblastoma stemness expression through senescence-associated reprogramming via HIF1alpha/HIF2alpha regulation. Wang P, Liao B, Gong S, Guo H, Zhao L, Liu J, Wu N. Cell Death Dis. 2025 Apr 19;16(1):317. doi: 10.1038/s41419-025-07617-w. PubMed |
| SLIRP amplifies antiviral signaling via positive feedback regulation and contributes to autoimmune diseases. Ku D, Yang Y, Park Y, Jang D, Lee N, Lee YK, Lee K, Lee J, Han YB, Jang S, Choi SR, Ha YJ, Choi YS, Jeong WJ, Lee YJ, Lee KJ, Cha S, Kim Y. Cell Rep. 2025 May 27;44(5):115588. doi: 10.1016/j.celrep.2025.115588. Epub 2025 Apr 19. PubMed |
| Reversible downregulation of HLA class I in adenoid cystic carcinoma. Li A, Gonda BL, Codd EM, von Paternos A, Mitchell DR, Herrmann MD, Kalyan P, Flynn SE, Dzu TQ, Gao C, Zhang E, Mendel JJ, Thierauf JC, Sadow PM, Denize T, Yang D, Fintelmann FJ, Fordham JA, Merkin RD, Bhan AK, Huang YC, Raizer J, Faquin WC, Faden DL, Gao X, Park JC, Wirth LJ, Kaluziak ST, Iafrate AJ. J Immunother Cancer. 2025 Apr 20;13(4):e011380. doi: 10.1136/jitc-2024-011380. PubMed |
Far-red chemigenetic kinase biosensors enable multiplexed and super-resolved imaging of signaling networks.
Frei MS, Sanchez SA, He X, Liu L, Schneider F, Wang Z, Hakozaki H, Li Y, Lyons AC, Rohm TV, Olefsky JM, Shi L, Schoneberg J, Fraser SE, Mehta S, Wang Y, Zhang J.
Nat Biotechnol. 2025 Apr 21. doi: 10.1038/s41587-025-02642-8.
PubMed
Associated Plasmids |
| Integrated analysis of molecular atlases unveils modules driving developmental cell subtype specification in the human cortex. Nano PR, Fazzari E, Azizad D, Martija A, Nguyen CV, Wang S, Giang V, Kan RL, Yoo J, Wick B, Haeussler M, Bhaduri A. Nat Neurosci. 2025 May;28(5):949-963. doi: 10.1038/s41593-025-01933-2. Epub 2025 Apr 21. PubMed |
| SAMHD1 knockout hiPSC model enables high lentiviral transduction efficiency in myeloid cell types. Li H, Afroze M, Arora G, Federman S, Shevade K, Yang YA, Nguyen P, Esanov R, Przybyla L, Litterman A, Shafer S. Front Genet. 2025 Apr 7;16:1574545. doi: 10.3389/fgene.2025.1574545. eCollection 2025. PubMed |
| Calcineurin-mediated regulation of growth-associated protein 43 is essential for neurite and synapse formation and protects against alpha-synuclein-induced degeneration. Grebenik E, Zaichick S, Caraveo G. Front Aging Neurosci. 2025 Apr 7;17:1566465. doi: 10.3389/fnagi.2025.1566465. eCollection 2025. PubMed |
| Reshaping the chromatin landscape in HUVECs from small-for-gestational-age newborns. Yan L, Zhou Z, Chen S, Feng X, Mao J, Luo F, Zhu J, Chen X, Hu Y, Wang Y, Wu B, Du L, Wang C, Gong L, Zhu Y. JCI Insight. 2025 Apr 22;10(8):e186812. doi: 10.1172/jci.insight.186812. eCollection 2025 Apr 22. PubMed |
| NEDDylation regulates CD8+ T cell metabolism and anti-tumor immunity. Jimenez-Lasheras B, Velasco-Beltran P, Egia-Mendikute L, Perez-Gutierrez L, Lee SY, de Blas A, Garcia Del Rio A, Zanetti SR, Antonana-Vildosola A, Barreira-Manrique A, Bosch A, Etxaniz Diaz de Durana J, Prieto-Fernandez E, Serrano-Macia M, Goikoetxea-Usandizaga N, Azkargorta M, Elortza F, Gruber T, Peer S, Baier G, Woodhoo A, Martinez-Chantar ML, Palazon A. Cancer Immunol Res. 2025 Apr 22. doi: 10.1158/2326-6066.CIR-24-0127. PubMed |
| Fluorescence-barcoded cell lines stably expressing membrane-anchored influenza neuraminidases. Finney J, Kuraoka M, Song S, Watanabe A, Liang X, Liao D, Moody MA, Walter EB, Harrison SC, Kelsoe G. Vaccine. 2025 May 22;56:127157. doi: 10.1016/j.vaccine.2025.127157. Epub 2025 Apr 21. PubMed |
| SFSWAP is a negative regulator of OGT intron detention and global pre-mRNA splicing. Govindan A, Conrad NK. Elife. 2025 Apr 23;13:RP104439. doi: 10.7554/eLife.104439. PubMed |
| Acute BRCAness induction and AR pathway blockage through CDK12/7/9 degradation enhances PARP inhibitor sensitivity in prostate cancer. Gui F, Jiang B, Jiang J, He Z, Tsujino T, Takai T, Arai S, Pana C, Kollermann J, Bradshaw GA, Eisert R, Kalocsay M, Fassl A, Balk SP, Kibel AS, Jia L. Sci Adv. 2025 Apr 25;11(17):eadu0847. doi: 10.1126/sciadv.adu0847. Epub 2025 Apr 23. PubMed |
| In vivo functional screens reveal KEAP1 loss as a driver of chemoresistance in small cell lung cancer. Brumage L, Best S, Hippe DS, Grunblatt E, Chanana P, Wu F, Lee MC, Ying Z, Ibrahim A, Chung JH, Vigil A, Fatherree J, Beronja S, Paddison P, Sullivan L, Nabet B, MacPherson D. Sci Adv. 2025 Apr 25;11(17):eadq7084. doi: 10.1126/sciadv.adq7084. Epub 2025 Apr 23. PubMed |
| IKAROS levels are associated with antigen escape in CD19- and CD22-targeted therapies for B-cell malignancies. Domizi P, Sarno J, Jager A, Merchant M, Pacheco KZB, Yamada-Hunter SA, Rotiroti MC, Liu Y, Baskar R, Reynolds WD, Sworder BJ, Sahaf B, Bendall SC, Mullighan CG, Alizadeh AA, Leahy AB, Myers RM, Yates B, Wang HW, Shah NN, Majzner RG, Mackall CL, Grupp SA, Barrett DM, Sotillo E, Davis KL. Nat Commun. 2025 Apr 23;16(1):3800. doi: 10.1038/s41467-025-58868-2. PubMed |
| Abnormal phosphorylation of human LRH1 at Ser510 predicts poor prognosis and promotes cell viability in lung squamous cell carcinoma. Mine H, Sugimoto K, Kobayashi M, Takagi H, Okabe N, Muto S, Kobayashi Y, Hashimoto Y, Suzuki H, Chiba H. BMC Cancer. 2025 Apr 23;25(1):764. doi: 10.1186/s12885-025-14160-6. PubMed |
| TRIM52 maintains cellular fitness and is under tight proteolytic control by multiple giant E3 ligases. Shulkina A, Hacker K, Ehrmann JF, Budroni V, Mandlbauer A, Bock J, Grabarczyk DB, Edobor G, Cochella L, Clausen T, Versteeg GA. Nat Commun. 2025 Apr 24;16(1):3894. doi: 10.1038/s41467-025-59129-y. PubMed |
| The mechanism of YAP/TAZ transactivation and dual targeting for cancer therapy. Yu M, Wang J, Zhang X, Zhang H, Li C, Li J, Lin J, Zheng J, Huang L, Li Y, Sun S. Nat Commun. 2025 Apr 24;16(1):3855. doi: 10.1038/s41467-025-59309-w. PubMed |
| SLAYER: a computational framework for identifying synthetic lethal interactions through integrated analysis of cancer dependencies. Cohen Z, Petrenko E, Barisaac AS, Abu-Zhayia ER, Yanovich-Ben-Uriel C, Ayoub N, Aran D. NAR Genom Bioinform. 2025 Apr 24;7(2):lqaf052. doi: 10.1093/nargab/lqaf052. eCollection 2025 Jun. PubMed |
| N-terminomics and proteomics analysis of Calpain-2 reveal key proteolytic processing of metabolic and cell adhesion proteins. Kapilan A, Bulluss M, Ziegler AR, Dabaja M, Derakhshani A, Anowai A, Armstrong V, Campden R, Young D, Sun YJ, Scott NE, Edgington-Mitchell LE, Mahajan VB, Dufour A. Protein Sci. 2025 May;34(5):e70144. doi: 10.1002/pro.70144. PubMed |
| Regulatory T Cell Mimicry by a Subset of Mesenchymal GBM Stem Cells Suppresses CD4 and CD8 Cells. Johnson AL, Khela HS, Korleski J, Sall S, Li Y, Zhou W, Smith-Connor K, Laterra J, Lopez-Bertoni H. Cells. 2025 Apr 14;14(8):592. doi: 10.3390/cells14080592. PubMed |
| Loss of neurofibromin induces inflammatory macrophage phenotypic switch and retinal neovascularization via GLUT1 activation. Zaidi Y, Tritz R, Zaidi N, Nabi F, Zaidi SAH, Morsy A, Harris V, Racine R, Hudson FZ, Bordan Z, Kennard S, Batori R, Huo Y, Csanyi G, Belin de Chantemele EJ, Lei K, Boulis NM, Fulton DJ, Khan RH, Caldwell RB, Stansfield BK. Cell Rep. 2025 May 27;44(5):115625. doi: 10.1016/j.celrep.2025.115625. Epub 2025 Apr 24. PubMed |
| Protecting centrosomes from fracturing enables efficient cell navigation. Schmitt MT, Kroll J, Ruiz-Fernandez MJA, Hauschild R, Ghosh S, Kameritsch P, Merrin J, Schmid J, Stefanowski K, Thomae AW, Cheng J, Oztan GN, Konopka P, Ortega GC, Penz T, Bach L, Baumjohann D, Bock C, Straub T, Meissner F, Kiermaier E, Renkawitz J. Sci Adv. 2025 Apr 25;11(17):eadx4047. doi: 10.1126/sciadv.adx4047. Epub 2025 Apr 25. PubMed |
| Single influenza A viruses induce nanoscale cellular reprogramming at the virus-cell interface. Broich L, Wullenkord H, Osman MK, Fu Y, Musken M, Reuther P, Bronstrup M, Sieben C. Nat Commun. 2025 Apr 25;16(1):3846. doi: 10.1038/s41467-025-58935-8. PubMed |
| Design and Characterization of Inhibitors of Cell-Mediated Degradation of APOBEC3G That Decrease HIV-1 Infectivity. Sawyer AM, Vaca CC, Malik N, Clerc I, Craft J, Hudson H, Scholtes GK, Schiltz GE, Roh M, Song C, D'Aquila RT. Viruses. 2025 Apr 1;17(4):514. doi: 10.3390/v17040514. PubMed |
| Characterization of Nanobody Binding to Distinct Regions of the SARS-CoV-2 Spike Protein by Flow Virometry. Maltseva M, Rossotti MA, Tanha J, Langlois MA. Viruses. 2025 Apr 15;17(4):571. doi: 10.3390/v17040571. PubMed |
| Ephrin B1 and B2 Mediate Cedar Virus Entry into Egyptian Fruit Bat Cells. Lenhard L, Muller M, Diederich S, Loerzer L, Friedrichs V, Kollner B, Finke S, Dorhoi A, Pei G. Viruses. 2025 Apr 16;17(4):573. doi: 10.3390/v17040573. PubMed |
| Targeted protein degraders of SARS-CoV-2 Mpro are more active than enzymatic inhibition alone with activity against nirmatrelvir resistant virus. Pan B, Mountford SJ, Kiso M, Anderson DE, Papadakis G, Jarman KE, Tilmanis DR, Maher B, Tran T, Shortt J, Yamayoshi S, Kawaoka Y, Thompson PE, Greenall SA, Warner N. Commun Med (Lond). 2025 Apr 26;5(1):140. doi: 10.1038/s43856-025-00863-1. PubMed |
| TPX2 promotes papillary renal cell carcinoma progression by forming a ceRNA with LINC00894. Ding Z, Ying W, Yan Y, Zhao Y, Liu C, Ma L. BMC Med Genomics. 2025 Apr 28;18(1):80. doi: 10.1186/s12920-025-02120-9. PubMed |
| Nuclear mitochondrial acetyl-CoA acetyltransferase 1 orchestrates natural killer cell-dependent antitumor immunity in colorectal cancer. Wei C, Liao K, Chen HJ, Xiao ZX, Meng Q, Liu ZK, Lu YX, Sheng H, Mo HY, Wu QN, Han Y, Zeng ZL, Guan XY, Luo HY, Ju HQ, Xu RH. Signal Transduct Target Ther. 2025 Apr 28;10(1):138. doi: 10.1038/s41392-025-02221-y. PubMed |
| Modulation of RASD2 by miRNA-485-5p Drives Thyroid Cancer Progression and Metastasis. Li XY, Sun JP, Guo H, Fan XQ, Zhang SS, Wang B, Yu N, Li QH. Kaohsiung J Med Sci. 2025 Jun;41(6):e70028. doi: 10.1002/kjm2.70028. Epub 2025 Apr 28. PubMed |
| N-acetyl-l-leucine lowers pS129-synuclein and improves synaptic function in models of Parkinson's disease. Song P, Franchini R, Chen C, Duong B, Wang YZ, Savas J, Parisiadou L, Krainc D. Res Sq [Preprint]. 2025 Apr 9:rs.3.rs-6298077. doi: 10.21203/rs.3.rs-6298077/v1. PubMed |
| Dynamic activation of rAAV transgene expression by a small molecule that recruits endogenous transcriptional machinery. Wasserman SR, Muron S, Lee HR, Routh ML, Hepperla AJ, Scoville DM, Huber A, Umana JD, Pereira NE, Foley CA, James LI, Hathaway NA. Nucleic Acids Res. 2025 Apr 22;53(8):gkaf345. doi: 10.1093/nar/gkaf345. PubMed |
| Efficient Generation of Megakaryocyte Progenitors and Platelets From HSPCs via JAK2/STAT3 Signaling. Liu H, Wang L, Liu J, Yuan H, Zhang K, Qiu Y, Zhu F. Adv Sci (Weinh). 2025 Jun;12(23):e2500612. doi: 10.1002/advs.202500612. Epub 2025 Apr 29. PubMed |
| A multi-strategy antimicrobial discovery approach reveals new ways to treat Chlamydia. Olander M, Rea Vazquez D, Meier K, Singh A, Silva de Sousa A, Puertolas-Balint F, Milivojevic M, Mooij L, Fredlund J, Calpe Bosch E, Rayon Diaz M, Lundgren M, van der Wal K, Zhu S, Mateus A, Schroeder BO, Lohman JR, Sixt BS. PLoS Biol. 2025 Apr 29;23(4):e3003123. doi: 10.1371/journal.pbio.3003123. eCollection 2025 Apr. PubMed |
Model-guided design of microRNA-based gene circuits supports precise dosage of transgenic cargoes into diverse primary cells.
Love KS, Johnstone CP, Peterman EL, Gaglione S, Birnbaum ME, Galloway KE.
Cell Syst. 2025 Apr 22:101269. doi: 10.1016/j.cels.2025.101269.
PubMed
Associated Plasmids |
| SNX17 mediates STAT3 activation to promote hepatocellular carcinoma progression via a retromer dependent mechanism. Liu Y, Tian W, Ge C, Zhang C, Huang Z, Zhang C, Yang Y, Tian H. Int J Biol Sci. 2025 Mar 31;21(6):2762-2779. doi: 10.7150/ijbs.110506. eCollection 2025. PubMed |
| Nonproteolytic ubiquitination regulates chromatin occupancy by the NCoR/SMRT/HDAC3 corepressor complex in MCF-7 breast cancer cells. Ferrero G, Cardamone MD, Luca F, Bourk E, Ricci L, Liu W, Gao Y, Burrone G, Muhammad A, Chan S, Smith E, Fan TC, Cutrupi S, Garcia-Bassets I, De Bortoli M, Rosenfeld MG, Perissi V. Proc Natl Acad Sci U S A. 2025 May 6;122(18):e2502805122. doi: 10.1073/pnas.2502805122. Epub 2025 Apr 30. PubMed |
| Implementing complex nucleic acid circuits in living cells. Sun J, Xiong X, Lai W, Wu Z, Wang H, Yang L, Xue N, Yao Q, Song G, Zhao Y, Li L, Wang F, Fan C, Pei H. Sci Adv. 2025 May 2;11(18):eadv6512. doi: 10.1126/sciadv.adv6512. Epub 2025 Apr 30. PubMed |
| Allelic effects on KLHL17 expression underlie a pancreatic cancer genome-wide association signal at chr1p36.33. Connelly KE, Hullin K, Abdolalizadeh E, Zhong J, Eiser D, O'Brien A, Collins I, Das S, Duncan G, Chanock SJ, Stolzenberg-Solomon RZ, Klein AP, Wolpin BM, Hoskins JW, Andresson T, Smith JP, Amundadottir LT. Nat Commun. 2025 Apr 30;16(1):4055. doi: 10.1038/s41467-025-59109-2. PubMed |
| The suppressive role of GLS in radiosensitivity and irradiation-induced immune response in LUAD: integrating bioinformatics and experimental insights. Jiang P, Jiang Z, Li S, Li YX, Chen Y, Li X. Front Immunol. 2025 Apr 16;16:1582587. doi: 10.3389/fimmu.2025.1582587. eCollection 2025. PubMed |
| Multi-omics landscape of alternative splicing in diffuse midline glioma reveals immune- and neural-driven subtypes with implications for spliceosome-targeted therapy. Liu C, Liu Y, Lin H, Zhang C, Zhang B, Song H, Fan X, Lyu Y, Yang H, Mao Y. Front Immunol. 2025 Apr 16;16:1587009. doi: 10.3389/fimmu.2025.1587009. eCollection 2025. PubMed |
| FLT4 activation promotes acute lymphoid leukemia survival through stabilization of MDM2/MDMX and inactivation of p53. Haferssas D, Dubuissez M, Barrera-Chimal J, Messmer C, Affar EB, Larrivee B, Liu XS, Gerarduzzi C. Oncogenesis. 2025 May 2;14(1):14. doi: 10.1038/s41389-025-00552-7. PubMed |
| Zic family member 5 promotes RIO kinase 3 expression to enhance pancreatic cancer survival. Satow R, Kashiwaba Y, Okao M, Takano S, Aiga Y, Yoneda A, Hosomichi K, Fukami K. FEBS J. 2025 May 3. doi: 10.1111/febs.70125. PubMed |
| The Integrated Stress Response Pathway Coordinates Translational Control of Multiple Immune Checkpoints in Lung Cancer. Thomas-Jardin S, Suresh S, Arce A, Novaresi N, Deng Q, Stein E, Thomas L, Lewis C, Ahn C, Evers BM, Akbay EA, Salvatierra ME, Lu W, Khan K, Solis Soto LM, Wistuba II, Minna JD, O'Donnell KA. Cancer Res. 2025 May 6. doi: 10.1158/0008-5472.CAN-24-3844. PubMed |
| mTORC1 cooperates with tRNA wobble modification to sustain the protein synthesis machinery. Hermann J, Bortecen T, Kalis R, Kowar A, Pechincha C, Vogt V, Schneider M, Helm D, Krijgsveld J, Loayza-Puch F, Zuber J, Palm W. Nat Commun. 2025 May 6;16(1):4201. doi: 10.1038/s41467-025-59185-4. PubMed |
| m(6)A/IGF2BP3-driven serine biosynthesis fuels AML stemness and metabolic vulnerability. Huang F, Wang Y, Zhang X, Gao W, Li J, Yang Y, Mo H, Prince E, Long Y, Hu J, Jiang C, Kang Y, Chen Z, Hu YC, Zeng C, Yang L, Chen CW, Chen J, Huang H, Weng H. Nat Commun. 2025 May 6;16(1):4214. doi: 10.1038/s41467-025-58966-1. PubMed |
| hsa-miR-5688 inhibits FOXC1-OCT4/SOX2 feedforward loop that drives chemoresistance in breast cancer stem cells. Dutta A, Chakraborty S, Bhattacharya A, Basak U, Pati S, Mukherjee S, Guha D, Banerjee S, Chaudhuri NR, Sarkar D, Jana K, Sa G, Dastidar SG, Das T. Mol Ther Oncol. 2025 Apr 8;33(2):200982. doi: 10.1016/j.omton.2025.200982. eCollection 2025 Jun 18. PubMed |
| Engineering Chromosome Bridges Through CRISPR/Cas9 to Decipher the Impact of Intercentromeric Distance on Resolution Dynamics. Anglada T, Rodriguez-Munoz M, Pulido-Artola N, Genesca A. FASEB J. 2025 May 15;39(9):e70599. doi: 10.1096/fj.202402258RR. PubMed |
| Sirt6 deficiency promotes senescence and age-associated intervertebral disc degeneration in mice. Ramteke P, Watson B, Toci M, Tran VA, Johnston S, Tsingas M, Barve RA, Mitra R, Loeser RF, Collins JA, Risbud MV. Bone Res. 2025 May 8;13(1):50. doi: 10.1038/s41413-025-00422-3. PubMed |
| p97/VCP is required for piecemeal autophagy of aggresomes. Korner M, Muller P, Das H, Kraus F, Pfeuffer T, Spielhaupter S, Oeljeklaus S, Schulein-Volk C, Harper JW, Warscheid B, Buchberger A. Nat Commun. 2025 May 7;16(1):4243. doi: 10.1038/s41467-025-59556-x. PubMed |
| A novel exploration of COL11A1's role in regulating myeloid-derived suppressor cell activation within the colon cancer microenvironment. Niu W, Du X, Song Y, Guo L, Liu B, Tong X. J Pharm Anal. 2025 Apr;15(4):101181. doi: 10.1016/j.jpha.2024.101181. Epub 2025 Jan 2. PubMed |
| Phagosomal RNA sensing through TLR8 controls susceptibility to tuberculosis. Maserumule C, Passemar C, Oh OSH, Hegyi K, Brown K, Weimann A, Dinan A, Davila S, Klapholz C, Bryant J, Verma D, Gadwa J, Krishnananthasivam S, Vongtongsalee K, Kendall E, Trelles A, Hibberd ML, Sanz J, Bertol J, Vazquez-Iniesta L, Andi K, Kumar SS, Ordway D, Prados-Rosales R, MacAry PA, Floto RA. Cell Rep. 2025 May 27;44(5):115657. doi: 10.1016/j.celrep.2025.115657. Epub 2025 May 6. PubMed |
| Antisense oligonucleotides directed against App and Rab5 normalized endosomal Rab activity and reversed DS-AD-linked degenerative phenotypes in the Dp16 mouse model of Down syndrome. Chen XQ, Zuo X, Becker A, Mante M, Florio JB, Jadhav SG, Albay R, Johnstone A, Karachentsev D, Rissman R, Zhao H, Dowdy SF, Mobley WC. Alzheimers Dement. 2025 May;21(5):e70022. doi: 10.1002/alz.70022. PubMed |
| Hyperactivation of RAB5 disrupts the endosomal Rab cascade leading to endolysosomal dysregulation in Down syndrome: A necessary role for increased APP gene dose. Chen XQ, Zuo X, Becker A, Mobley WC. Alzheimers Dement. 2025 May;21(5):e70046. doi: 10.1002/alz.70046. PubMed |
| Innovative evaluation of selinexor and JQ1 synergy in leukemia therapy via C-MYC inhibition. Wang PH, Hu CH, Fan JQ, He JJ, Deng TF, Xu YL, Dai YJ, Wang SQ. J Transl Med. 2025 May 8;23(1):520. doi: 10.1186/s12967-025-06525-z. PubMed |
| Predicting adenine base editing efficiencies in different cellular contexts by deep learning. Kissling L, Mollaysa A, Janjuha S, Mathis N, Marquart KF, Weber Y, Moon WJ, Lin PJC, Fan SHY, Muramatsu H, Vadovics M, Allam A, Pardi N, Tam YK, Krauthammer M, Schwank G. Genome Biol. 2025 May 8;26(1):115. doi: 10.1186/s13059-025-03586-7. PubMed |
| PDZ domains of PATJ facilitate immunological synapse formation to promote T cell activation. Xiong X, Wang D, Xu L, Chen S, He J, Zhang X, Fang Z, Zhang J, Li W, Zhou P. J Immunother Cancer. 2025 May 7;13(5):e010966. doi: 10.1136/jitc-2024-010966. PubMed |
| LCMR1 deficiency exacerbates LPS‑induced lung injury in lung‑on‑a‑chip and mouse models. Mo Z, Su C, Liu J, Ren J, Liu L, Wang Y, Li Y, Li C, Yang Z, Ma X, Chen L. Mol Med Rep. 2025 Jul;32(1):189. doi: 10.3892/mmr.2025.13554. Epub 2025 May 9. PubMed |
| The m((5))C methyltransferase NSUN2 promotes progression of acute myeloid leukemia by regulating serine metabolism. Li S, Liu Y, Wu X, Pan M, Zhao H, Hong Y, Zhang Q, Hu S, Ouyang A, Li G, Wu M, Fan S, Jia Z, Zhao S, Wu G, Gao X, Yang Z, Chen Z. Cell Rep. 2025 May 27;44(5):115661. doi: 10.1016/j.celrep.2025.115661. Epub 2025 May 8. PubMed |
| Immunosequencing identifies signatures of T cell responses for early detection of nasopharyngeal carcinoma. Zhang S, Zhou Y, Liu Z, Wang Y, Zhou X, Chen H, Zhang X, Chen Y, Feng Q, Ye X, Xie S, Zeng MS, Zhai W, Zeng YX, Cao S, Li G, Xu M. Cancer Cell. 2025 May 6:S1535-6108(25)00168-0. doi: 10.1016/j.ccell.2025.04.009. PubMed |
| Design principles of cell-state-specific enhancers in hematopoiesis. Fromel R, Ruhle J, Bernal Martinez A, Szu-Tu C, Pacheco Pastor F, Martinez-Corral R, Velten L. Cell. 2025 Jun 12;188(12):3202-3218.e21. doi: 10.1016/j.cell.2025.04.017. Epub 2025 May 8. PubMed |
| KAT5 regulates neurodevelopmental states associated with G0-like populations in glioblastoma. Mihalas AB, Arora S, O'Connor SA, Feldman HM, Cucinotta CE, Mitchell K, Bassett J, Kim D, Jin K, Hoellerbauer P, Delegard J, Ling M, Jenkins W, Kufeld M, Corrin P, Carter L, Tsukiyama T, Aronow B, Plaisier CL, Patel AP, Paddison PJ. Nat Commun. 2025 May 9;16(1):4327. doi: 10.1038/s41467-025-59503-w. PubMed |
| Hypoxia and HIF-1 inhibition enhance lentiviral transduction efficiency: a novel strategy for gene delivery optimization. Huo Q, Wang W, Dai J, Yuan X, Yu D, Xu B, Chi Y, Li H, Pei XL, Zhu G, Zhang L. BMC Biotechnol. 2025 May 10;25(1):34. doi: 10.1186/s12896-025-00969-3. PubMed |
| SLK is mutated in individuals with a neurodevelopmental disorder. Alabdi L, Altuwaijri N, Zhu JY, Efthymiou S, Lee H, Duan J, Salem I, Yu P, Abdullah NL, Alzahrani F, Xu Q, Felemban MM, Alfaifi A, Rahman F, Christoforou M, Maqbool S, Martinez-Agosto JA, Alsaif HS, Hashem M, Helaby R, Alsulaiman A, Maroofian R, Houlden H, Arold ST, Ibrahim LA, Han Z, Alkuraya FS. EBioMedicine. 2025 Jun;116:105725. doi: 10.1016/j.ebiom.2025.105725. Epub 2025 May 9. PubMed |
| A multimodal screening platform for endogenous dipeptide repeat proteins in C9orf72 patient iPSC neurons. Holbling BV, Gupta Y, Marchi PM, Atilano ML, Flower M, Urena E, Goulden RA, Dobbs HK, Katona E, Mikheenko A, Giblin A, Awan AR, Fisher-Ward CL, O'Brien N, Vaizoglu D, Kempthorne L, Wilson KM, Gittings LM, Carcole M, Ruepp MD, Mizielinska S, Partridge L, Fratta P, Tabrizi SJ, Selvaraj BT, Chandran S, Armstrong E, Whiting P, Isaacs AM. Cell Rep. 2025 May 27;44(5):115695. doi: 10.1016/j.celrep.2025.115695. Epub 2025 May 10. PubMed |
| Condensation-dependent multivalent interactions of EB1 and CENP-R regulate chromosome oscillations in mitosis. Hu C, Hu Q, Yang T, Xu P, Xiong F, Wang X, Wang C, Jiang K, Hill DL, Xue L, Tao C, Fu C, Zhang L, Liu D, Xiang S, Zang J, Wang Z, Yao X, Liu X. Cell Rep. 2025 May 27;44(5):115560. doi: 10.1016/j.celrep.2025.115560. Epub 2025 May 9. PubMed |
| IRE1alpha promotes phagosomal calcium flux to enhance macrophage fungicidal activity. McFadden MJ, Reynolds MB, Michmerhuizen BC, Olafsson EB, Marshall SM, Davis FA, Schultz TL, Iwawaki T, Sexton JZ, O'Riordan MXD, O'Meara TR. Cell Rep. 2025 May 27;44(5):115694. doi: 10.1016/j.celrep.2025.115694. Epub 2025 May 9. PubMed |
| A dual-fluorescence assay for gene delivery vehicle screening in macrophages with an inflammation-inducible reporter construct. Ivy A, Bess SN, Agrawal S, Kochar V, Stokes AL, Muldoon TJ, Nelson CE. BMC Methods. 2025;2(1):8. doi: 10.1186/s44330-025-00030-x. Epub 2025 May 8. PubMed |
| SARS-CoV-2 ORF3a drives dynamic dense body formation for optimal viral infectivity. Hartmann S, Radochonski L, Ye C, Martinez-Sobrido L, Chen J. Nat Commun. 2025 May 12;16(1):4393. doi: 10.1038/s41467-025-59475-x. PubMed |
| Reannotation of cancer mutations based on expressed RNA transcripts reveals functional non-coding mutations in melanoma. Pepe D, Janssens X, Timcheva K, Marron-Linares GM, Verbelen B, Konstantakos V, De Groote D, De Bie J, Verhasselt A, Dewaele B, Godderis A, Cools C, Franco-Tolsau M, Royaert J, Verbeeck J, Kampen KR, Subramanian K, Cabrerizo Granados D, Menschaert G, De Keersmaecker K. Am J Hum Genet. 2025 Jun 5;112(6):1447-1467. doi: 10.1016/j.ajhg.2025.04.005. Epub 2025 May 12. PubMed |
| Profiling triple-negative breast cancer-specific super-enhancers identifies high-risk mesenchymal development subtype and BETi-Targetable vulnerabilities. Chen QS, Cai RZ, Wang Y, Liang GH, Zhang KM, Yang XY, Yang D, Zhao DC, Zhu XF, Deng R, Tang J. Mol Cancer. 2025 May 13;24(1):141. doi: 10.1186/s12943-025-02342-6. PubMed |
| Suppression of Ovarian Cancer Cell Proliferation Is Associated with Upregulation of Cell-Matrix Adhesion Programs and Integrin-beta4-Induced Cell Protection from Cisplatin. Farsinejad S, Centeno D, Savas-Carstens J, Polotaye T, Pavlovic T, Babvey P, Muranen T, Miedziarek C, Jasinski P, Dziabaszewska E, Zaborowski MP, Lum PY, Martin LA, Iwanicki MP. Cancers (Basel). 2025 Apr 27;17(9):1472. doi: 10.3390/cancers17091472. PubMed |
| TurboID Labeling and Analysis of Proteins in the Primary Cilium. Liu X, Ge X. Bio Protoc. 2025 May 5;15(9):e5303. doi: 10.21769/BioProtoc.5303. eCollection 2025 May 5. PubMed |
| AHCYL1 mediates the tumor-promoting effect of PREX2 in non-small cell lung carcinoma. Lei M, Yeung YT, Nie W, Yang R, Li J, Chen H, Zhao R, Liu K, Dong Z. Theranostics. 2025 Apr 21;15(12):5772-5789. doi: 10.7150/thno.108654. eCollection 2025. PubMed |
| Dipyridamole Acts as Clinical Ferroptosis Inhibitor to Prevent from Tissue Injury. Zhuang X, Shi S, Liu S, Jiao Y, Huang B, Yang Y, Yang L, Yang X, Wang H, Liang C, Song D, Yu H, Zou D, Sun Q, Yang S, Yin C, Li J, Liu Y, Min J, Wang F, Nian Y, Du L, Chu B. Adv Sci (Weinh). 2025 Jun;12(23):e2500566. doi: 10.1002/advs.202500566. Epub 2025 May 14. PubMed |
| Identification of a Biomarker Panel in Extracellular Vesicles Derived From Non-Small Cell Lung Cancer (NSCLC) Through Proteomic Analysis and Machine Learning. Yuan Y, Jiang H, Xue R, Feng XJ, Liu BF, Li L, Peng B, Ren CS, Li SM, Li N, Li M, Wang DB, Zhang XE. J Extracell Vesicles. 2025 May;14(5):e70078. doi: 10.1002/jev2.70078. PubMed |
| Incomplete paralog compensation generates selective dependency on TRA2A in cancer. Lee AR, Tangiyan A, Singh I, Choi PS. PLoS Genet. 2025 May 14;21(5):e1011685. doi: 10.1371/journal.pgen.1011685. eCollection 2025 May. PubMed |
| Epstein-Barr virus latent membrane protein 1 subverts IMPDH pathways to drive B-cell oncometabolism. Burton EM, Maestri D, White S, Liang JH, Mitra B, Asara JM, Gewurz BE. PLoS Pathog. 2025 May 14;21(5):e1013092. doi: 10.1371/journal.ppat.1013092. eCollection 2025 May. PubMed |
| Inherited deficiency of DIAPH1 identifies a DNA double strand break repair pathway regulated by gamma-actin. Woodward BL, Lahiri S, Chauhan AS, Garcia MR, Goodley LE, Clarke TL, Pal M, Agathanggelou A, Jhujh SS, Ganesh AN, Hollins FM, Deforie VG, Maroofian R, Efthymiou S, Meinhardt A, Mathew CG, Simpson MA, Mefford HC, Faqeih EA, Rosenzweig SD, Volpi S, Di Matteo G, Cancrini C, Scardamaglia A, Shackley F, Davies EG, Ibrahim S, Arkwright PD, Zaki MS, Stankovic T, Taylor AMR, Mazur AJ, Di Donato N, Houlden H, Rothenberg E, Stewart GS. Nat Commun. 2025 May 14;16(1):4491. doi: 10.1038/s41467-025-59553-0. PubMed |
| IGFBP3 enhances adipose-derived stem cell function in soft tissue injury repair via ITGB1 and ERK pathway activation. Tian S, Yu H, Yang R, Wang H, Zhao B, Wang D. Cell Biol Toxicol. 2025 May 15;41(1):85. doi: 10.1007/s10565-025-10024-8. PubMed |
| RBM15-mediated metabolic reprogramming boosts immune response in colorectal cancer. Wang C, Chen M, Chen P, Han J, Hu H, Chen J, Wu Q, Zhao D, Wang T, Zhou J, Li Q, Zhou R, Wen Y, Yang J, Shi M, Wang Y. Front Immunol. 2025 Apr 30;16:1515568. doi: 10.3389/fimmu.2025.1515568. eCollection 2025. PubMed |
| DEPP1: A prognostic biomarker linked to stroma‑rich and immunosuppressive microenvironment, promoting oxaliplatin resistance in gastric cancer. Qiu X, Pan T, Kuang T, Shen Y, Zheng Y, Geng H, Ni B, Xia X, Zhu C, Zhang Z, Cao H, Tu L. Oncol Rep. 2025 Jul;54(1):82. doi: 10.3892/or.2025.8915. Epub 2025 May 16. PubMed |
| Calpains orchestrate secretion of annexin-containing microvesicles during membrane repair. Williams JK, Ngo JM, Murugupandiyan A, Croall DE, Hartzell HC, Schekman R. J Cell Biol. 2025 Jul 7;224(7):e202408159. doi: 10.1083/jcb.202408159. Epub 2025 May 16. PubMed |
| Chromatin modification abnormalities by CHD7 and KMT2C loss promote medulloblastoma progression. Wang W, Kumegawa K, Chapman OS, Shiraishi R, Xiao Z, Okonechnikov K, Sun Y, Pfister SM, Feng W, Uesaka N, Hoshino M, Takahashi S, Korshunov A, Chavez L, Maruyama R, Kawauchi D. Cell Rep. 2025 May 27;44(5):115673. doi: 10.1016/j.celrep.2025.115673. Epub 2025 May 19. PubMed |
| Targeting WEE1 in tumor-associated dendritic cells potentiates antitumor immunity via the cGAS/STING pathway. Ng II, Zhang Z, Xiao K, Ye M, Tian T, Zhu Y, He Y, Chu L, Tang H. Cell Rep. 2025 Jun 24;44(6):115733. doi: 10.1016/j.celrep.2025.115733. Epub 2025 May 20. PubMed |
| Targeting COL5A1 enhances anoikis thus attenuating malignancy of glioblastoma via inhibiting the Wnt/beta-catenin signaling pathway. Zhou M, Wu W, Wang Y, Zhang B, Zhao X, Zhou H, Cao Y, Wu P, Wang M, Wang J. J Neurooncol. 2025 Aug;174(1):97-109. doi: 10.1007/s11060-025-05036-7. Epub 2025 May 22. PubMed |
| Division of labor among H3K4 methyltransferases defines distinct facets of homeostatic plasticity. Tsukahara T, Kethireddy S, Bonefas KM, Chen A, Sutton BLM, Bandow K, Dou Y, Iwase S, Sutton MA. Cell Rep. 2025 Jun 24;44(6):115746. doi: 10.1016/j.celrep.2025.115746. Epub 2025 May 21. PubMed |
| PUS10-induced tRNA fragmentation impacts retrotransposon-driven inflammation. Madej M, Ngoc PCT, Muthukumar S, Konturek-Ciesla A, Tucciarone S, Germanos A, Ashworth C, Kotarsky K, Ghosh S, Fan Z, Fritz H, Pascual-Gonzalez I, Huerta A, Guzzi N, Colazzo A, Beneventi G, Lee HM, Ciesla M, Douse C, Kato H, Swaminathan V, Agace WW, Castellanos-Rubio A, Salomoni P, Bryder D, Bellodi C. Cell Rep. 2025 Jun 24;44(6):115735. doi: 10.1016/j.celrep.2025.115735. Epub 2025 May 21. PubMed |
| HBV sequence integrated to enhancer acting as oncogenic driver epigenetically promotes hepatocellular carcinoma development. Chen L, Li W, Zai W, Zheng X, Meng X, Yao Q, Li W, Liang Y, Ye M, Zhou K, Liu M, Yang Z, Mao Z, Wei H, Yang S, Shi G, Yuan Z, Yu W. J Exp Clin Cancer Res. 2025 May 22;44(1):155. doi: 10.1186/s13046-025-03413-8. PubMed |
| Delta-catenin is required for cell proliferation in virus-positive Merkel cell carcinoma cell lines but not in human fibroblasts. Landazuri Vinueza J, Salisbury NJH, Dye KN, Roman A, Galloway DA. mBio. 2025 Jun 11;16(6):e0083225. doi: 10.1128/mbio.00832-25. Epub 2025 May 23. PubMed |
| Engineered vasculature induces functional maturation of pluripotent stem cell-derived islet organoids. Jun Y, Nguyen-Ngoc KV, Sai S, Bender RHF, Gong W, Kravets V, Zhu H, Hatch CJ, Schlichting M, Gaetani R, Mallick M, Hachey SJ, Christman KL, George SC, Hughes CCW, Sander M. Dev Cell. 2025 May 20:S1534-5807(25)00262-X. doi: 10.1016/j.devcel.2025.04.024. PubMed |
| hnRNPL phase separation activates PIK3CB transcription and promotes glycolysis in ovarian cancer. Qin F, Wang Y, Yang C, Ren Y, Wei Q, Tang Y, Xu J, Wang H, Luo F, Luo Q, Luo X, Liu X, Yang D, Zuo X, Yang Y, Cheng C, Xu J, Wang W, Liu T, Yi P. Nat Commun. 2025 May 24;16(1):4828. doi: 10.1038/s41467-025-60115-7. PubMed |
| Targeting the Exonic Circular OGT RNA/O-GlcNAc Transferase/Forkhead Box C1 Axis Inhibits Asparagine- and Alanine-Mediated Ferroptosis Repression in Neuroblastoma Progression. Li Q, Cheng Y, Yang C, Tian M, Wang X, Li D, Li X, Qu J, Zhou S, Zheng L, Tong Q. Research (Wash D C). 2025 May 23;8:0703. doi: 10.34133/research.0703. eCollection 2025. PubMed |
| NXPE1 alters the sialoglycome by acetylating sialic acids in the human colon. Lee BS, Cook A, Sur S, Dobbyn L, Popoli M, Khalili S, Zhou S, Bettegowda C, Papadopoulos N, Gabrielson K, Buckhaults P, Vogelstein B, Kinzler KW, Wyhs N. Nat Commun. 2025 May 27;16(1):4912. doi: 10.1038/s41467-025-59671-9. PubMed |
| Evolutionary and functional analyses reveal a role for the RHIM in tuning RIPK3 activity across vertebrates. Fay EJ, Isterabadi K, Rezanka CM, Le J, Daugherty MD. Elife. 2025 May 28;13:RP102301. doi: 10.7554/eLife.102301. PubMed |
| Machine-learning-assisted universal protein activation in living mice. Wang X, Liu Y, Wang Z, Zeng X, Ngai WSC, Wang J, Zhang H, Xie X, Zhu R, Fan X, Wang C, Chen PR. Cell. 2025 Jul 10;188(14):3696-3714.e24. doi: 10.1016/j.cell.2025.05.006. Epub 2025 May 27. PubMed |
| IGF2BP1 restricts the induction of human primordial germ cell fate in an m(6)A-dependent manner. Zhang J, Gu Y, Tong L, Feng B, Dong S, Shao Q, Chen Y, Tu H, Wang Z, Wang Y, Li X, Yu H, Lin Z, Wang X, Li Z, Ai Z, Xiang Y, Jiang Z, Jin Z, Li Z, Chen Y, Shen Z, Huang C, Liu J, Liu J, Xu P, Yu Y, Xia P, Liang H, Huang H, Chen D. Cell Stem Cell. 2025 Jul 3;32(7):1122-1138.e13. doi: 10.1016/j.stem.2025.05.001. Epub 2025 May 27. PubMed |
| Combined therapy with DR5-targeting antibody-drug conjugate and CDK inhibitors as a strategy for advanced colorectal cancer. Zhou D, Tang E, Wang W, Xiao Y, Huang J, Liu J, Zheng C, Zhang K, Hu R, Wang F, Xiong P, Chu X, Li W, Liu D, Zeng X, Zheng D, Wang L, Zheng Y, Zhang S. Cell Rep Med. 2025 Jun 17;6(6):102158. doi: 10.1016/j.xcrm.2025.102158. Epub 2025 May 30. PubMed |
| Coiled-coil-domain-mediated TRIM E3 protein condensation modulates enzymatic activity and functional specificity. Chen Q, Yang P. Cell Rep. 2025 Jun 24;44(6):115766. doi: 10.1016/j.celrep.2025.115766. Epub 2025 May 30. PubMed |
| BRCA2 reversion mutation-independent resistance to PARP inhibition through impaired DNA prereplication complex function. Pappas K, Ferrari M, Smith P, Nandakumar S, Khan Z, Young SB, LaClair J, Russo MV, Huang-Hobbs E, Schultz N, Abida W, Karthaus W, Jasin M, L Sawyers C. Proc Natl Acad Sci U S A. 2025 Jun 10;122(23):e2426743122. doi: 10.1073/pnas.2426743122. Epub 2025 Jun 3. PubMed |
| NFATC2/SERPINE1/JAK3/STAT3 signaling feedback loop in gastric cancer: immune evasion and anti-PD-1 resistance. Yang Z, Zhong D, Hu X, Chen W, Liao Y, He X. Cell Biol Toxicol. 2025 Jun 13;41(1):102. doi: 10.1007/s10565-025-10050-6. PubMed |
| HNF4A promotes tumor progression in gastric cancer by transcriptional activation of KIF2C. Lu H, Gan JH, Zhou LQ, Yuan YW, Zhou Q, Xin L. Clin Exp Med. 2025 Jun 14;25(1):205. doi: 10.1007/s10238-025-01748-2. PubMed |
| RSK1-driven TRIM28/E2F1 feedback loop promotes castration-resistant prostate cancer progression. Kim M, Liu J, Zhang Y, Wang R, Goettl R, Grasso J, Allison DB, Wang C, Gao T, Liu X, Fong KW. J Clin Invest. 2025 Jun 16;135(12):e185119. doi: 10.1172/JCI185119. eCollection 2025 Jun 16. PubMed |
| Repurposing MDM2 inhibitor RG7388 for TP53-mutant NSCLC: a p53-independent pyroptotic mechanism via ROS/p-p38/NOXA/caspase-3/GSDME axis. Tang G, Cao X, Chen J, Hui F, Xu N, Jiang Y, Lu H, Xiao H, Liang X, Ma M, Qian Y, Liu D, Wang Z, Liu S, Yu G, Sun L. Cell Death Dis. 2025 Jun 17;16(1):452. doi: 10.1038/s41419-025-07770-2. PubMed |
| Extracellular vesicles derived from mature dendritic cells loaded with cDC1-specific chemokine XCL1 combined with chemotherapy-induced ICD for the treatment of castration-resistant prostate cancer. Fan Z, Wang Z, Zhang H, Zhang H, Zhao R, Zhu S, Liu X. Cancer Immunol Immunother. 2025 Jun 18;74(8):242. doi: 10.1007/s00262-025-04070-8. PubMed |
| PI3K-dependent GAB1/Erk phosphorylation renders head and neck squamous cell carcinoma sensitive to PI3Kalpha inhibitors. Zhang X, Xu J, Wang X, Xu L, Zhang X, Wang Y, Jiang S, Zhang Y, Ding J, Qing C, Meng L. Cell Death Dis. 2025 Jun 18;16(1):457. doi: 10.1038/s41419-025-07767-x. PubMed |
| USP37 prevents premature disassembly of stressed replisomes by TRAIP. Kochenova OV, D'Alessandro G, Pilger D, Schmid E, Richards SL, Garcia MR, Jhujh SS, Voigt A, Gupta V, Carnie CJ, Alex Wu R, Gueorguieva N, Lam S, Stewart GS, Walter JC, Jackson SP. Nat Commun. 2025 Jun 18;16(1):5333. doi: 10.1038/s41467-025-60139-z. PubMed |
| Protocol to implement saturation mutagenesis-reinforced functional assays to resolve small-sized variants in disease-related genes. Gauthier LO, Wang Z, Ng KK, Huang S, Mao Y, Lek M, Ma K. STAR Protoc. 2025 Jun 19;6(3):103909. doi: 10.1016/j.xpro.2025.103909. PubMed |
| Endothelial soluble epoxide hydrolase links polyunsaturated fatty acid metabolism to oxidative stress and atherosclerosis progression. Cao M, Li M, Li X, Li Y, Chen Y, Drekolia MK, Cheng X, Lagos FD, Bibli SI, Hu J. Redox Biol. 2025 Jun 14;85:103730. doi: 10.1016/j.redox.2025.103730. PubMed |
High-content image-based pooled screens reveal regulators of synaptogenesis.
Le A, Biederer T, Blainey PC.
Cell Rep. 2025 Jun 24;44(7):115889. doi: 10.1016/j.celrep.2025.115889.
PubMed
Associated Plasmids |
| De novo assembly of RNA m(6)A modification factors into viral genome-associated nuclear bodies drives HCMV RNA accumulation. Grande RC, Lin CC, Cammer M, Emesom ED, Khurram MA, Boutell C, Denes LT, Lionnet T, Wilson AC, Mohr I. Cell Rep. 2025 Jul 22;44(7):115826. doi: 10.1016/j.celrep.2025.115826. Epub 2025 Jun 24. PubMed |
| RIPK1 senses S-adenosylmethionine scarcity to drive cell death and inflammation. Chen Z, Gu X, Chen H, Zhang H, Liu J, Yang X, Cai Y, Zhang M, Yan L, Yang Y, Shan B, Zhu ZJ, Zhang Y, Gu J, Xu D. Cell Metab. 2025 Aug 5;37(8):1732-1749.e9. doi: 10.1016/j.cmet.2025.05.014. Epub 2025 Jun 25. PubMed |
| Phenotypic screens for SIRPA expression reveal RAB21 as a general regulator of macrophage surface identity. Granda Farias A, Feng B, Khan S, Ngo W, Wu JLY, Aguilera-Uribe M, Grewal S, Mero P, Singh SK, Kislinger T, Chan WCW, Moffat J. Cell Rep. 2025 Jul 22;44(7):115921. doi: 10.1016/j.celrep.2025.115921. Epub 2025 Jun 27. PubMed |
| Tailoring a novel colorectal cancer stem cell-targeted therapy by inhibiting the SMYD3/c-MYC axis. Lepore Signorile M, Di Nicola E, Forte G, Sanese P, Fasano C, Disciglio V, De Marco K, Latrofa M, De Cecco L, Ficorilli M, Lucchetta M, Torchia E, Dossena C, Bianco G, Spilotro V, Ferroni C, Labarile N, Armentano R, Albano F, Mestice A, Gigante G, Lantone V, Lantone G, Vincenti L, Del Rio A, Varchi G, Grossi V, Simone C. Signal Transduct Target Ther. 2025 Jun 30;10(1):206. doi: 10.1038/s41392-025-02290-z. PubMed |
| Klf5-adjacent super-enhancer functions as a 3D genome structure-dependent transcriptional driver to safeguard ESC identity. Su G, Chen B, Song Y, Yin Q, Wang W, Zhao X, Fan S, Lian J, Li D, Bi J, Li P, Zhao Z, Zhang L, Shi J, Lu W. Nat Commun. 2025 Jul 1;16(1):5540. doi: 10.1038/s41467-025-60389-x. PubMed |
| Spatially resolved C1QC(+) macrophage-CD4(+) T cell niche in colorectal cancer microenvironment: implications for immunotherapy response. Zhang H, Hong L, Dong Z, Xin S, Lin B, Cheng J, Tian W, Li B, Wang J, Liu X, Liu C, Jin Y, Feng Y, Su G, Sun X, Liu Q, Dai X, Gao Y, Tong Z, Liu L, Zhu X, Zheng Y, Zhao P, Guo T, Fang W, Bao X. Cell Discov. 2025 Jul 1;11(1):60. doi: 10.1038/s41421-025-00811-2. PubMed |
| p62 mRNA suppresses NLRP1 expression in cutaneous SCC cells through miR-34a-5p. Hennig P, Turko P, Di Filippo M, Levesque MP, Kundig T, Beer HD. Cell Death Dis. 2025 Jul 1;16(1):465. doi: 10.1038/s41419-025-07785-9. PubMed |
| CFAP100 couples microtubule glutamylation to spindle pole integrity in keratinocytes to promote epidermal development. Sun S, Wang Z, Xu Z, Wang Z, Sun J, Li K, Liu M, Zhao H, Liu P, Zhou J. Nat Commun. 2025 Jul 1;16(1):5591. doi: 10.1038/s41467-025-60677-6. PubMed |
| Enhanced reverse zoonotic potential and immune evasion by omicron JN.1 variant. Hu J, Zan F, He Y, Ou X, Tang X, Liu Y, Lu X, Li P, Mu Z, Dong S, Chen Y, Tan L, Cao M, Liu P, Tsz-Tai Yuen T, Lu J, Qian Z. iScience. 2025 Jun 6;28(7):112824. doi: 10.1016/j.isci.2025.112824. eCollection 2025 Jul 18. PubMed |
| Legionella pneumophila modulates the host cytoskeleton by an effector of transglutaminase activity. Liu Y, Liu Y, Luo ZQ. mLife. 2025 Jun 18;4(3):232-248. doi: 10.1002/mlf2.70013. eCollection 2025 Jun. PubMed |
| Enhancing CAR-T Cell Metabolic Fitness and Memory Phenotype for Improved Efficacy against Hepatocellular Carcinoma. You J, Yang X, Zhao J, Chen H, Tang Y, Ouyang D, Liu Y, Wang Y, Xie S, Chen Y, Liao J, Xiang T, Xia J, Yang C, Weng D. Int J Biol Sci. 2025 Jun 20;21(9):4231-4251. doi: 10.7150/ijbs.110406. eCollection 2025. PubMed |
| Coupling of glucose metabolism with mitophagy via O-GlcNAcylation of PINK1. Xu Z, Gao X, Rong D, Wang J, Gao L, Tang M, Chen Y, Zhang Y, Xie L, Wang L, Lu G, Lu JH, Liu W, Shen HM. Int J Biol Sci. 2025 Jun 20;21(9):4252-4269. doi: 10.7150/ijbs.112672. eCollection 2025. PubMed |
| WNT5B regulates myogenesis and fiber type conversion by affecting mRNA stability. Fan D, Yao Y, Yan C, Li F, Yang Y, Xie B, Tang Z. Int J Biol Sci. 2025 Jun 9;21(9):3934-3948. doi: 10.7150/ijbs.102309. eCollection 2025. PubMed |
| Various anthracyclines exhibit differential cytotoxic effects related to CBR1-induced resistance in lung cancer cells. Piska K, Koczurkiewicz-Adamczyk P, Kochanowski P, Bobis-Wozowicz S, Wladyka B, Pekala E. Med Oncol. 2025 Jul 8;42(8):315. doi: 10.1007/s12032-025-02893-0. PubMed |
| RBM14 enhances transcriptional activity of p23 regulating CXCL1 expression to induce lung cancer metastasis. Zhang W, Peng Y, Zhou M, Qian L, Che Y, Chen J, Zhang W, He C, Qi M, Shu X, Tian M, Tian X, Tian Y, Deng S, Wang Y, Huo X, Yu Z, Ma X. Acta Pharm Sin B. 2025 Jun;15(6):3059-3072. doi: 10.1016/j.apsb.2025.03.048. Epub 2025 Apr 4. PubMed |
A proximity-labeling-based approach to directly detect mRNA delivery to specific subcellular locations.
Smart AD, Hughes ME, Ruiz Velasco AD, Hori N, Stolnik S, Jopling CL.
Mol Ther Nucleic Acids. 2025 Jun 24;36(3):102602. doi: 10.1016/j.omtn.2025.102602. eCollection 2025 Sep 9.
PubMed
Associated Plasmids |
| METTL3-mediated m(6)A methylation of lncRNA PVT1 promotes the progression of oral squamous cell carcinoma via the miR-185-5p/SERPINB4 axis. Chen C, Li J, Yang B, Kong L, Zhang D, Guo J, Zhou L, Bai G, Zhao H, Meng Z. Am J Cancer Res. 2025 Jun 25;15(6):2872-2889. doi: 10.62347/HERV8396. eCollection 2025. PubMed |
| Expression of DNAJB1-PRKACA oncogene suppresses the differentiation potential of liver progenitor organoids towards a hepatocyte lineage. DiPietro E, Bharath N, Karski M, Durfee O, Sherman MS, Ma Q, Sun L, Farghli AR, Smith CJ, Kycia I, Sethupathy P, Goessling W, Rogers MS, Vakili K. Sci Rep. 2025 Jul 16;15(1):25796. doi: 10.1038/s41598-025-11028-4. PubMed |
If you have published an article using this material, please email us at [email protected] to have your article added to this page.