pMD2.G Citations (6384)
Originally described in: Trono Lab Packaging and Envelope PlasmidsUnpublished
Articles Citing pMD2.G
| Articles |
|---|
| New cell lines from mouse epiblast share defining features with human embryonic stem cells. Tesar PJ, Chenoweth JG, Brook FA, Davies TJ, Evans EP, Mack DL, Gardner RL, McKay RD. Nature. 2007 Jul 12. 448(7150):196-9. PubMed |
| Determination of the transforming activities of adenovirus oncogenes. Nevels M, Dobner T. Methods Mol Med. 2007;131:187-95. PubMed |
| Up-regulation of c-FLIP short by NFAT contributes to apoptosis resistance of short-term activated T cells. Ueffing N, Schuster M, Keil E, Schulze-Osthoff K, Schmitz I. Blood. 2008 Aug 1;112(3):690-8. doi: 10.1182/blood-2008-02-141382. Epub 2008 May 28. PubMed |
| CCL2 protects prostate cancer PC3 cells from autophagic death via phosphatidylinositol 3-kinase/AKT-dependent survivin up-regulation. Roca H, Varsos Z, Pienta KJ. J Biol Chem. 2008 Sep 5;283(36):25057-73. doi: 10.1074/jbc.M801073200. Epub 2008 Jul 8. PubMed |
| Feeder-free culture of human embryonic stem cells in conditioned medium for efficient genetic modification. Braam SR, Denning C, Matsa E, Young LE, Passier R, Mummery CL. Nat Protoc. 2008;3(9):1435-43. doi: 10.1038/nprot.2008.140. PubMed |
| The scaffold protein JSAP1 regulates proliferation and differentiation of cerebellar granule cell precursors by modulating JNK signaling. Sato T, Torashima T, Sugihara K, Hirai H, Asano M, Yoshioka K. Mol Cell Neurosci. 2008 Dec;39(4):569-78. doi: 10.1016/j.mcn.2008.08.003. Epub 2008 Aug 30. PubMed |
| Functional involvement of RINF, retinoid-inducible nuclear factor (CXXC5), in normal and tumoral human myelopoiesis. Pendino F, Nguyen E, Jonassen I, Dysvik B, Azouz A, Lanotte M, Segal-Bendirdjian E, Lillehaug JR. Blood. 2009 Apr 2;113(14):3172-81. doi: 10.1182/blood-2008-07-170035. Epub 2009 Jan 30. PubMed |
| A functional genomic screen identifies cellular cofactors of hepatitis C virus replication. Tai AW, Benita Y, Peng LF, Kim SS, Sakamoto N, Xavier RJ, Chung RT. Cell Host Microbe. 2009 Mar 19;5(3):298-307. doi: 10.1016/j.chom.2009.02.001. PubMed |
| In vitro and in vivo validation of human and goat chondrocyte labeling by green fluorescent protein lentivirus transduction. Miot S, Gianni-Barrera R, Pelttari K, Acharya C, Mainil-Varlet P, Juelke H, Jaquiery C, Candrian C, Barbero A, Martin I. Tissue Eng Part C Methods. 2010 Feb;16(1):11-21. doi: 10.1089/ten.TEC.2008.0698. PubMed |
| TNFAIP3 (A20) is a tumor suppressor gene in Hodgkin lymphoma and primary mediastinal B cell lymphoma. Schmitz R, Hansmann ML, Bohle V, Martin-Subero JI, Hartmann S, Mechtersheimer G, Klapper W, Vater I, Giefing M, Gesk S, Stanelle J, Siebert R, Kuppers R. J Exp Med. 2009 May 11;206(5):981-9. doi: 10.1084/jem.20090528. Epub 2009 Apr 20. PubMed |
| Tumor microvasculature supports proliferation and expansion of glioma-propagating cells. Borovski T, Verhoeff JJ, ten Cate R, Cameron K, de Vries NA, van Tellingen O, Richel DJ, van Furth WR, Medema JP, Sprick MR. Int J Cancer. 2009 Sep 1;125(5):1222-30. doi: 10.1002/ijc.24408. PubMed |
| Molecular dissection of the ILK-PINCH-parvin triad reveals a fundamental role for the ILK kinase domain in the late stages of focal-adhesion maturation. Stanchi F, Grashoff C, Nguemeni Yonga CF, Grall D, Fassler R, Van Obberghen-Schilling E. J Cell Sci. 2009 Jun 1;122(Pt 11):1800-11. doi: 10.1242/jcs.044602. Epub 2009 May 12. PubMed |
| In vivo genetic manipulation of the rat trophoblast cell lineage using lentiviral vector delivery. Lee DS, Rumi MA, Konno T, Soares MJ. Genesis. 2009 Jul;47(7):433-9. doi: 10.1002/dvg.20518. PubMed |
| Sequential cooperation of CD2 and CD48 in the buildup of the early TCR signalosome. Muhammad A, Schiller HB, Forster F, Eckerstorfer P, Geyeregger R, Leksa V, Zlabinger GJ, Sibilia M, Sonnleitner A, Paster W, Stockinger H. J Immunol. 2009 Jun 15;182(12):7672-80. doi: 10.4049/jimmunol.0800691. PubMed |
| Tubulin polymerization-promoting protein (TPPP/p25) is critical for oligodendrocyte differentiation. Lehotzky A, Lau P, Tokesi N, Muja N, Hudson LD, Ovadi J. Glia. 2010 Jan 15;58(2):157-68. doi: 10.1002/glia.20909. PubMed |
| Long term non-invasive imaging of embryonic stem cells using reporter genes. Sun N, Lee A, Wu JC. Nat Protoc. 2009;4(8):1192-201. doi: 10.1038/nprot.2009.100. Epub 2009 Jul 23. PubMed |
| Transforming growth-interacting factor (TGIF) regulates proliferation and differentiation of human myeloid leukemia cells. Hamid R, Brandt SJ. Mol Oncol. 2009 Dec;3(5-6):451-63. doi: 10.1016/j.molonc.2009.07.004. Epub 2009 Jul 29. PubMed |
| Variegation and silencing in a lentiviral-based murine transgenic model. Baup D, Fraga L, Pernot E, Van Acker A, Vanherck AS, Breckpot K, Thielemans K, Schurmans S, Moser M, Leo O. Transgenic Res. 2010 Jun;19(3):399-414. doi: 10.1007/s11248-009-9318-4. Epub 2009 Aug 23. PubMed |
| Multipurpose modular lentiviral vectors for RNA interference and transgene expression. Kesireddy V, van der Ven PF, Furst DO. Mol Biol Rep. 2010 Jul;37(6):2863-70. doi: 10.1007/s11033-009-9840-8. Epub 2009 Oct 2. PubMed |
| Amyotrophic lateral sclerosis-linked mutant SOD1 sequesters Hu antigen R (HuR) and TIA-1-related protein (TIAR): implications for impaired post-transcriptional regulation of vascular endothelial growth factor. Lu L, Wang S, Zheng L, Li X, Suswam EA, Zhang X, Wheeler CG, Nabors LB, Filippova N, King PH. J Biol Chem. 2009 Dec 4. 284(49):33989-98. PubMed |
| Developmental regulation of the composite CAG promoter activity in the murine T lymphocyte cell lineage. Baup D, Moser M, Schurmans S, Leo O. Genesis. 2009 Dec;47(12):799-804. doi: 10.1002/dvg.20569. PubMed |
| Inducible APOBEC3G-Vif double stable cell line as a high-throughput screening platform to identify antiviral compounds. Nowotny B, Schneider T, Pradel G, Schirmeister T, Rethwilm A, Kirschner M. Antimicrob Agents Chemother. 2010 Jan;54(1):78-87. doi: 10.1128/AAC.00775-09. Epub 2009 Oct 19. PubMed |
| Reversibly immortalized human olfactory ensheathing glia from an elderly donor maintain neuroregenerative capacity. Lim F, Martin-Bermejo MJ, Garcia-Escudero V, Gallego-Hernandez MT, Garcia-Gomez A, Rabano A, Diaz-Nido J, Avila J, Moreno-Flores MT. Glia. 2010 Apr;58(5):546-58. doi: 10.1002/glia.20944. PubMed |
| Transcription factors RUNX1 and RUNX3 in the induction and suppressive function of Foxp3+ inducible regulatory T cells. Klunker S, Chong MM, Mantel PY, Palomares O, Bassin C, Ziegler M, Ruckert B, Meiler F, Akdis M, Littman DR, Akdis CA. J Exp Med. 2009 Nov 23;206(12):2701-15. doi: 10.1084/jem.20090596. Epub 2009 Nov 16. PubMed |
| Prevention of senescence progression in reversibly immortalized human ensheathing glia permits their survival after deimmortalization. García-Escudero V, García-Gómez A, Gargini R, Martín-Bermejo MJ, Langa E, de Yébenes JG, Delicado A, Avila J, Moreno-Flores MT, Lim F. Mol Ther. 2010 Feb . 18(2):394-403. PubMed |
| Cocal-pseudotyped lentiviral vectors resist inactivation by human serum and efficiently transduce primate hematopoietic repopulating cells. Trobridge GD, Wu RA, Hansen M, Ironside C, Watts KL, Olsen P, Beard BC, Kiem HP. Mol Ther. 2010 Apr;18(4):725-33. doi: 10.1038/mt.2009.282. Epub 2009 Dec 8. PubMed |
| Lentiviral gene transduction in human and mouse NK cell lines. Savan R, Chan T, Young HA. Methods Mol Biol. 2010;612:209-21. doi: 10.1007/978-1-60761-362-6_14. PubMed |
| HEF1 is a crucial mediator of the proliferative effects of prostaglandin E(2) on colon cancer cells. Xia D, Holla VR, Wang D, Menter DG, DuBois RN. Cancer Res. 2010 Jan 15;70(2):824-31. doi: 10.1158/0008-5472.CAN-09-2105. Epub 2010 Jan 12. PubMed |
Gateway-compatible lentiviral transfer vectors for ubiquitin promoter driven expression of fluorescent fusion proteins.
Krupka N, Strappe P, Gotz J, Ittner LM.
Plasmid. 2010 May;63(3):155-60. doi: 10.1016/j.plasmid.2010.01.002. Epub 2010 Feb 2.
PubMed
Associated Plasmids |
| An inducible Tet-Off-H2B-GFP lentiviral reporter vector for detection and in vivo isolation of label-retaining cells. Falkowska-Hansen B, Kollar J, Gruner BM, Schanz M, Boukamp P, Siveke J, Rethwilm A, Kirschner M. Exp Cell Res. 2010 Jul 1;316(11):1885-95. doi: 10.1016/j.yexcr.2010.02.015. Epub 2010 Feb 18. PubMed |
| Tumor necrosis factor receptor superfamily member 19 (TNFRSF19) regulates differentiation fate of human mesenchymal (stromal) stem cells through canonical Wnt signaling and C/EBP. Qiu W, Hu Y, Andersen TE, Jafari A, Li N, Chen W, Kassem M. J Biol Chem. 2010 May 7;285(19):14438-49. doi: 10.1074/jbc.M109.052001. Epub 2010 Mar 11. PubMed |
| Lentiviral vector-mediated transgenesis in human embryonic stem cells. Du ZW, Zhang SC. Methods Mol Biol. 2010;614:127-34. doi: 10.1007/978-1-60761-533-0_8. PubMed |
| Aire regulates the expression of differentiation-associated genes and self-renewal of embryonic stem cells. Gu B, Zhang J, Chen Q, Tao B, Wang W, Zhou Y, Chen L, Liu Y, Zhang M. Biochem Biophys Res Commun. 2010 Apr 2. 394(2):418-23. PubMed |
| Pbx1 represses osteoblastogenesis by blocking Hoxa10-mediated recruitment of chromatin remodeling factors. Gordon JA, Hassan MQ, Saini S, Montecino M, van Wijnen AJ, Stein GS, Stein JL, Lian JB. Mol Cell Biol. 2010 Jul;30(14):3531-41. doi: 10.1128/MCB.00889-09. Epub 2010 May 3. PubMed |
| Differential splicing of the apoptosis-associated speck like protein containing a caspase recruitment domain (ASC) regulates inflammasomes. Bryan NB, Dorfleutner A, Kramer SJ, Yun C, Rojanasakul Y, Stehlik C. J Inflamm (Lond). 2010 May 18;7:23. doi: 10.1186/1476-9255-7-23. PubMed |
| The cell-specific induction of CXC chemokine ligand 9 mediated by IFN-gamma in microglia of the central nervous system is determined by the myeloid transcription factor PU.1. Ellis SL, Gysbers V, Manders PM, Li W, Hofer MJ, Muller M, Campbell IL. J Immunol. 2010 Aug 1;185(3):1864-77. doi: 10.4049/jimmunol.1000900. Epub 2010 Jun 28. PubMed |
| A novel, retromer-independent role for sorting nexins 1 and 2 in RhoG-dependent membrane remodeling. Prosser DC, Tran D, Schooley A, Wendland B, Ngsee JK. Traffic. 2010 Oct;11(10):1347-62. doi: 10.1111/j.1600-0854.2010.01100.x. PubMed |
| EGFR/Met association regulates EGFR TKI resistance in breast cancer. Mueller KL, Yang ZQ, Haddad R, Ethier SP, Boerner JL. J Mol Signal. 2010 Jul 12;5:8. doi: 10.1186/1750-2187-5-8. PubMed |
| Two functionally distinct isoforms of TL1A (TNFSF15) generated by differential ectodomain shedding. Muck C, Herndler-Brandstetter D, Micutkova L, Grubeck-Loebenstein B, Jansen-Durr P. J Gerontol A Biol Sci Med Sci. 2010 Nov;65(11):1165-80. doi: 10.1093/gerona/glq129. Epub 2010 Jul 30. PubMed |
| A neuroregenerative human ensheathing glia cell line with conditional rapid growth. Garcia-Escudero V, Gargini R, Gallego-Hernandez MT, Garcia-Gomez A, Martin-Bermejo MJ, Simon D, Delicado A, Moreno-Flores MT, Avila J, Lim F. Cell Transplant. 2011;20(2):153-66. doi: 10.3727/096368910X522108. Epub 2010 Aug 18. PubMed |
| Expression of miR-33 from an SREBP2 intron inhibits cholesterol export and fatty acid oxidation. Gerin I, Clerbaux LA, Haumont O, Lanthier N, Das AK, Burant CF, Leclercq IA, MacDougald OA, Bommer GT. J Biol Chem. 2010 Oct 29;285(44):33652-61. doi: 10.1074/jbc.M110.152090. Epub 2010 Aug 22. PubMed |
| Stable overexpression of miRNAs in bone marrow-derived murine mast cells using lentiviral expression vectors. Mayoral RJ, Monticelli S. Methods Mol Biol. 2010;667:205-14. doi: 10.1007/978-1-60761-811-9_14. PubMed |
| Incremental genetic perturbations to MCM2-7 expression and subcellular distribution reveal exquisite sensitivity of mice to DNA replication stress. Chuang CH, Wallace MD, Abratte C, Southard T, Schimenti JC. PLoS Genet. 2010 Sep 9;6(9):e1001110. doi: 10.1371/journal.pgen.1001110. PubMed |
| Syntaxin 3 is necessary for cAMP- and cGMP-regulated exocytosis of CFTR: implications for enterotoxigenic diarrhea. Collaco A, Marathe J, Kohnke H, Kravstov D, Ameen N. Am J Physiol Cell Physiol. 2010 Dec;299(6):C1450-60. doi: 10.1152/ajpcell.00029.2010. Epub 2010 Sep 15. PubMed |
| Role for PKC delta in Fenretinide-Mediated Apoptosis in Lymphoid Leukemia Cells. Ruvolo VR, Karanjeet KB, Schuster TF, Brown R, Deng Y, Hinchcliffe E, Ruvolo PP. J Signal Transduct. 2010 Jan 1;2010:584657. PubMed |
| ATR and ATRIP are recruited to herpes simplex virus type 1 replication compartments even though ATR signaling is disabled. Mohni KN, Livingston CM, Cortez D, Weller SK. J Virol. 2010 Dec;84(23):12152-64. doi: 10.1128/JVI.01643-10. Epub 2010 Sep 22. PubMed |
| Induced pluripotent stem cell models of the genomic imprinting disorders Angelman and Prader-Willi syndromes. Chamberlain SJ, Chen PF, Ng KY, Bourgois-Rocha F, Lemtiri-Chlieh F, Levine ES, Lalande M. Proc Natl Acad Sci U S A. 2010 Oct 12;107(41):17668-73. doi: 10.1073/pnas.1004487107. Epub 2010 Sep 27. PubMed |
| Dual selection mechanisms drive efficient single-gene reverse genetics for rotavirus. Trask SD, Taraporewala ZF, Boehme KW, Dermody TS, Patton JT. Proc Natl Acad Sci U S A. 2010 Oct 26;107(43):18652-7. doi: 10.1073/pnas.1011948107. Epub 2010 Oct 11. PubMed |
| The SR-BI partner PDZK1 facilitates hepatitis C virus entry. Eyre NS, Drummer HE, Beard MR. PLoS Pathog. 2010 Oct 7;6(10):e1001130. doi: 10.1371/journal.ppat.1001130. PubMed |
| Silencing of CDK5 reduces neurofibrillary tangles in transgenic alzheimer's mice. Piedrahita D, Hernandez I, Lopez-Tobon A, Fedorov D, Obara B, Manjunath BS, Boudreau RL, Davidson B, Laferla F, Gallego-Gomez JC, Kosik KS, Cardona-Gomez GP. J Neurosci. 2010 Oct 20;30(42):13966-76. doi: 10.1523/JNEUROSCI.3637-10.2010. PubMed |
| Combining theoretical analysis and experimental data generation reveals IRF9 as a crucial factor for accelerating interferon alpha-induced early antiviral signalling. Maiwald T, Schneider A, Busch H, Sahle S, Gretz N, Weiss TS, Kummer U, Klingmuller U. FEBS J. 2010 Nov;277(22):4741-54. doi: 10.1111/j.1742-4658.2010.07880.x. Epub 2010 Oct 21. PubMed |
Large intergenic non-coding RNA-RoR modulates reprogramming of human induced pluripotent stem cells.
Loewer S, Cabili MN, Guttman M, Loh YH, Thomas K, Park IH, Garber M, Curran M, Onder T, Agarwal S, Manos PD, Datta S, Lander ES, Schlaeger TM, Daley GQ, Rinn JL.
Nat Genet. 2010 Dec;42(12):1113-7. Epub 2010 Nov 7.
PubMed
Associated Plasmids |
| The TRAF-interacting protein (TRIP) is a regulator of keratinocyte proliferation. Almeida S, Ryser S, Obarzanek-Fojt M, Hohl D, Huber M. J Invest Dermatol. 2011 Feb;131(2):349-57. doi: 10.1038/jid.2010.329. Epub 2010 Nov 11. PubMed |
| Prolylcarboxypeptidase regulates proliferation, autophagy, and resistance to 4-hydroxytamoxifen-induced cytotoxicity in estrogen receptor-positive breast cancer cells. Duan L, Motchoulski N, Danzer B, Davidovich I, Shariat-Madar Z, Levenson VV. J Biol Chem. 2011 Jan 28;286(4):2864-76. doi: 10.1074/jbc.M110.143271. Epub 2010 Nov 17. PubMed |
| T cell receptor (TCR)-induced tyrosine phosphorylation dynamics identifies THEMIS as a new TCR signalosome component. Brockmeyer C, Paster W, Pepper D, Tan CP, Trudgian DC, McGowan S, Fu G, Gascoigne NR, Acuto O, Salek M. J Biol Chem. 2011 Mar 4;286(9):7535-47. doi: 10.1074/jbc.M110.201236. Epub 2010 Dec 28. PubMed |
| Akt1 deletion prevents lung tumorigenesis by mutant K-ras. Hollander MC, Maier CR, Hobbs EA, Ashmore AR, Linnoila RI, Dennis PA. Oncogene. 2011 Apr 14;30(15):1812-21. doi: 10.1038/onc.2010.556. Epub 2011 Jan 17. PubMed |
| Human umbilical cord-derived Schwann-like cell transplantation combined with neurotrophin-3 administration in dyskinesia of rats with spinal cord injury. Yan-Wu G, Yi-Quan K, Ming L, Ying-Qian C, Xiao-Dan J, Shi-Zhong Z, Wang-Ming Z, Chuan-Zhi D. Neurochem Res. 2011 May;36(5):783-92. doi: 10.1007/s11064-011-0402-9. Epub 2011 Jan 18. PubMed |
| Senescence-associated heterochromatin foci are dispensable for cellular senescence, occur in a cell type- and insult-dependent manner and follow expression of p16(ink4a). Kosar M, Bartkova J, Hubackova S, Hodny Z, Lukas J, Bartek J. Cell Cycle. 2011 Feb 1;10(3):457-68. Epub 2011 Feb 1. PubMed |
| Yes-associated protein (YAP) transcriptional coactivator functions in balancing growth and differentiation in skin. Zhang H, Pasolli HA, Fuchs E. Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2270-5. doi: 10.1073/pnas.1019603108. Epub 2011 Jan 24. PubMed |
| JNK signaling promotes intestinal tumorigenesis through activation of mTOR complex 1 in Apc(Delta716) mice. Fujishita T, Aoki M, Taketo MM. Gastroenterology. 2011 May;140(5):1556-63.e6. doi: 10.1053/j.gastro.2011.02.007. Epub 2011 Feb 12. PubMed |
| High-throughput screening of microscale pitted substrate topographies for enhanced nonviral transfection efficiency in primary human fibroblasts. Adler AF, Speidel AT, Christoforou N, Kolind K, Foss M, Leong KW. Biomaterials. 2011 May;32(14):3611-9. doi: 10.1016/j.biomaterials.2011.01.040. Epub 2011 Feb 21. PubMed |
| Recapitulation of premature ageing with iPSCs from Hutchinson-Gilford progeria syndrome. Liu GH, Barkho BZ, Ruiz S, Diep D, Qu J, Yang SL, Panopoulos AD, Suzuki K, Kurian L, Walsh C, Thompson J, Boue S, Fung HL, Sancho-Martinez I, Zhang K, Yates J 3rd, Izpisua Belmonte JC. Nature. 2011 Apr 14;472(7342):221-5. doi: 10.1038/nature09879. Epub 2011 Feb 23. PubMed |
| The neuronal differentiation factor NeuroD1 downregulates the neuronal repellent factor Slit2 expression and promotes cell motility and tumor formation of neuroblastoma. Huang P, Kishida S, Cao D, Murakami-Tonami Y, Mu P, Nakaguro M, Koide N, Takeuchi I, Onishi A, Kadomatsu K. Cancer Res. 2011 Apr 15;71(8):2938-48. doi: 10.1158/0008-5472.CAN-10-3524. Epub 2011 Feb 24. PubMed |
| SirT3 suppresses hypoxia inducible factor 1alpha and tumor growth by inhibiting mitochondrial ROS production. Bell EL, Emerling BM, Ricoult SJ, Guarente L. Oncogene. 2011 Jun 30;30(26):2986-96. doi: 10.1038/onc.2011.37. Epub 2011 Feb 28. PubMed |
| Somatic coding mutations in human induced pluripotent stem cells. Gore A, Li Z, Fung HL, Young JE, Agarwal S, Antosiewicz-Bourget J, Canto I, Giorgetti A, Israel MA, Kiskinis E, Lee JH, Loh YH, Manos PD, Montserrat N, Panopoulos AD, Ruiz S, Wilbert ML, Yu J, Kirkness EF, Izpisua Belmonte JC, Rossi DJ, Thomson JA, Eggan K, Daley GQ, Goldstein LS, Zhang K. Nature. 2011 Mar 3;471(7336):63-7. doi: 10.1038/nature09805. PubMed |
| S1P lyase regulates DNA damage responses through a novel sphingolipid feedback mechanism. Kumar A, Oskouian B, Fyrst H, Zhang M, Paris F, Saba JD. Cell Death Dis. 2011 Feb 10;2:e119. doi: 10.1038/cddis.2011.3. PubMed |
| Lentiviral vector mediated modification of mesenchymal stem cells & enhanced survival in an in vitro model of ischaemia. McGinley L, McMahon J, Strappe P, Barry F, Murphy M, O'Toole D, O'Brien T. Stem Cell Res Ther. 2011 Mar 7;2(2):12. doi: 10.1186/scrt53. PubMed |
| Mutation and loss of expression of ARID1A in uterine low-grade endometrioid carcinoma. Guan B, Mao TL, Panuganti PK, Kuhn E, Kurman RJ, Maeda D, Chen E, Jeng YM, Wang TL, Shih IeM. Am J Surg Pathol. 2011 May;35(5):625-32. doi: 10.1097/PAS.0b013e318212782a. PubMed |
| Anthrax lethal factor activates K(+) channels to induce IL-1beta secretion in macrophages. Thomas J, Epshtein Y, Chopra A, Ordog B, Ghassemi M, Christman JW, Nattel S, Cook JL, Levitan I. J Immunol. 2011 May 1;186(9):5236-43. doi: 10.4049/jimmunol.1001078. Epub 2011 Mar 18. PubMed |
| Histone demethylase JMJD2B functions as a co-factor of estrogen receptor in breast cancer proliferation and mammary gland development. Kawazu M, Saso K, Tong KI, McQuire T, Goto K, Son DO, Wakeham A, Miyagishi M, Mak TW, Okada H. PLoS One. 2011 Mar 18;6(3):e17830. doi: 10.1371/journal.pone.0017830. PubMed |
| HIV infection enhances TRAIL-induced cell death in macrophage by down-regulating decoy receptor expression and generation of reactive oxygen species. Zhu DM, Shi J, Liu S, Liu Y, Zheng D. PLoS One. 2011 Apr 5;6(4):e18291. doi: 10.1371/journal.pone.0018291. PubMed |
| The NLR adaptor ASC/PYCARD regulates DUSP10, mitogen-activated protein kinase (MAPK), and chemokine induction independent of the inflammasome. Taxman DJ, Holley-Guthrie EA, Huang MT, Moore CB, Bergstralh DT, Allen IC, Lei Y, Gris D, Ting JP. J Biol Chem. 2011 Jun 3;286(22):19605-16. doi: 10.1074/jbc.M111.221077. Epub 2011 Apr 12. PubMed |
| Efficient preparation and labeling of human induced pluripotent stem cells by nanotechnology. Ruan J, Shen J, Wang Z, Ji J, Song H, Wang K, Liu B, Li J, Cui D. Int J Nanomedicine. 2011;6:425-35. doi: 10.2147/IJN.S16498. Epub 2011 Feb 21. PubMed |
| mTORC1 inhibition increases neurotensin secretion and gene expression through activation of the MEK/ERK/c-Jun pathway in the human endocrine cell line BON. Li J, Liu J, Song J, Wang X, Weiss HL, Townsend CM Jr, Gao T, Evers BM. Am J Physiol Cell Physiol. 2011 Jul;301(1):C213-26. doi: 10.1152/ajpcell.00067.2011. Epub 2011 Apr 20. PubMed |
| Human cytomegalovirus IE1 protein elicits a type II interferon-like host cell response that depends on activated STAT1 but not interferon-gamma. Knoblach T, Grandel B, Seiler J, Nevels M, Paulus C. PLoS Pathog. 2011 Apr;7(4):e1002016. doi: 10.1371/journal.ppat.1002016. Epub 2011 Apr 14. PubMed |
| Modeling initiation of Ewing sarcoma in human neural crest cells. von Levetzow C, Jiang X, Gwye Y, von Levetzow G, Hung L, Cooper A, Hsu JH, Lawlor ER. PLoS One. 2011 Apr 29;6(4):e19305. doi: 10.1371/journal.pone.0019305. PubMed |
| The function of hypoxia-inducible factor (HIF) is independent of the endoplasmic reticulum protein OS-9. Brockmeier U, Platzek C, Schneider K, Patak P, Bernardini A, Fandrey J, Metzen E. PLoS One. 2011 Apr 29;6(4):e19151. doi: 10.1371/journal.pone.0019151. PubMed |
| Epigenetic regulation of early osteogenesis and mineralized tissue formation by a HOXA10-PBX1-associated complex. Gordon JA, Hassan MQ, Koss M, Montecino M, Selleri L, van Wijnen AJ, Stein JL, Stein GS, Lian JB. Cells Tissues Organs. 2011;194(2-4):146-50. doi: 10.1159/000324790. Epub 2011 May 19. PubMed |
| Deptor knockdown enhances mTOR Activity and protein synthesis in myocytes and ameliorates disuse muscle atrophy. Kazi AA, Hong-Brown L, Lang SM, Lang CH. Mol Med. 2011 Sep-Oct;17(9-10):925-36. doi: 10.2119/molmed.2011.00070. Epub 2011 May 19. PubMed |
| Transforming growth factor beta controls CCN3 expression in nucleus pulposus cells of the intervertebral disc. Tran CM, Smith HE, Symes A, Rittie L, Perbal B, Shapiro IM, Risbud MV. Arthritis Rheum. 2011 Oct;63(10):3022-31. doi: 10.1002/art.30468. PubMed |
| Faster generation of hiPSCs by coupling high-titer lentivirus and column-based positive selection. Dick E, Matsa E, Young LE, Darling D, Denning C. Nat Protoc. 2011 Jun;6(6):701-14. doi: 10.1038/nprot.2011.320. Epub 2011 May 5. PubMed |
| Lipid raft localization of EGFR alters the response of cancer cells to the EGFR tyrosine kinase inhibitor gefitinib. Irwin ME, Mueller KL, Bohin N, Ge Y, Boerner JL. J Cell Physiol. 2011 Sep;226(9):2316-28. doi: 10.1002/jcp.22570. PubMed |
| Stable knockdown of MYCN by lentivirus-based RNAi inhibits human neuroblastoma cells growth in vitro and in vivo. Jiang R, Xue S, Jin Z. Biochem Biophys Res Commun. 2011 Jul 1;410(2):364-70. doi: 10.1016/j.bbrc.2011.06.020. Epub 2011 Jun 12. PubMed |
| L-3-Phosphoserine phosphatase (PSPH) regulates cutaneous squamous cell carcinoma proliferation independent of L-serine biosynthesis. Bachelor MA, Lu Y, Owens DM. J Dermatol Sci. 2011 Sep;63(3):164-72. doi: 10.1016/j.jdermsci.2011.06.001. Epub 2011 Jun 22. PubMed |
| Hypoxia leads to Na,K-ATPase downregulation via Ca(2+) release-activated Ca(2+) channels and AMPK activation. Gusarova GA, Trejo HE, Dada LA, Briva A, Welch LC, Hamanaka RB, Mutlu GM, Chandel NS, Prakriya M, Sznajder JI. Mol Cell Biol. 2011 Sep;31(17):3546-56. doi: 10.1128/MCB.05114-11. Epub 2011 Jul 5. PubMed |
| Lentiviral-mediated knockdown during ex vivo erythropoiesis of human hematopoietic stem cells. Palii CG, Pasha R, Brand M. J Vis Exp. 2011 Jul 16;(53). pii: 2813. doi: 10.3791/2813. PubMed |
| Endothelial cells create a stem cell niche in glioblastoma by providing NOTCH ligands that nurture self-renewal of cancer stem-like cells. Zhu TS, Costello MA, Talsma CE, Flack CG, Crowley JG, Hamm LL, He X, Hervey-Jumper SL, Heth JA, Muraszko KM, DiMeco F, Vescovi AL, Fan X. Cancer Res. 2011 Sep 15;71(18):6061-72. doi: 10.1158/0008-5472.CAN-10-4269. Epub 2011 Jul 25. PubMed |
| Transduction of human cells with polymer-complexed ecotropic lentivirus for enhanced biosafety. Barrilleaux B, Knoepfler P. J Vis Exp. 2011 Jul 24;(53). pii: 2822. doi: 10.3791/2822. PubMed |
| Derivation of induced pluripotent stem cells by lentiviral transduction. Nethercott HE, Brick DJ, Schwartz PH. Methods Mol Biol. 2011;767:67-85. doi: 10.1007/978-1-61779-201-4_6. PubMed |
| CYP2S1 and CYP2W1 mediate 2-(3,4-dimethoxyphenyl)-5-fluorobenzothiazole (GW-610, NSC 721648) sensitivity in breast and colorectal cancer cells. Tan BS, Tiong KH, Muruhadas A, Randhawa N, Choo HL, Bradshaw TD, Stevens MF, Leong CO. Mol Cancer Ther. 2011 Oct;10(10):1982-92. doi: 10.1158/1535-7163.MCT-11-0391. Epub 2011 Aug 10. PubMed |
Effect of Ser-129 phosphorylation on interaction of alpha-synuclein with synaptic and cellular membranes.
Visanji NP, Wislet-Gendebien S, Oschipok LW, Zhang G, Aubert I, Fraser PE, Tandon A.
J Biol Chem. 2011 Oct 14;286(41):35863-73. Epub 2011 Aug 17.
PubMed
Associated Plasmids |
| Loss of transcription factor KLF5 in the context of p53 ablation drives invasive progression of human squamous cell cancer. Yang Y, Nakagawa H, Tetreault MP, Billig J, Victor N, Goyal A, Sepulveda AR, Katz JP. Cancer Res. 2011 Oct 15;71(20):6475-84. doi: 10.1158/0008-5472.CAN-11-1702. Epub 2011 Aug 25. PubMed |
| Dickkopf-3 maintains the PANC-1 human pancreatic tumor cells in a dedifferentiated state. Zenzmaier C, Hermann M, Hengster P, Berger P. Int J Oncol. 2012 Jan;40(1):40-6. doi: 10.3892/ijo.2011.1180. Epub 2011 Aug 29. PubMed |
ARID1A, a factor that promotes formation of SWI/SNF-mediated chromatin remodeling, is a tumor suppressor in gynecologic cancers.
Guan B, Wang TL, Shih IeM.
Cancer Res. 2011 Nov 1;71(21):6718-27. Epub 2011 Sep 7.
PubMed
Associated Plasmids |
| Daedalus: a robust, turnkey platform for rapid production of decigram quantities of active recombinant proteins in human cell lines using novel lentiviral vectors. Bandaranayake AD, Correnti C, Ryu BY, Brault M, Strong RK, Rawlings DJ. Nucleic Acids Res. 2011 Nov;39(21):e143. doi: 10.1093/nar/gkr706. Epub 2011 Sep 12. PubMed |
| FOSL1 is integral to establishing the maternal-fetal interface. Kent LN, Rumi MA, Kubota K, Lee DS, Soares MJ. Mol Cell Biol. 2011 Dec;31(23):4801-13. doi: 10.1128/MCB.05780-11. Epub 2011 Sep 26. PubMed |
| Inhibition of mTOR kinase by AZD8055 can antagonize chemotherapy-induced cell death through autophagy induction and down-regulation of p62/sequestosome 1. Huang S, Yang ZJ, Yu C, Sinicrope FA. J Biol Chem. 2011 Nov 18;286(46):40002-12. doi: 10.1074/jbc.M111.297432. Epub 2011 Sep 23. PubMed |
| DNA mismatch repair proteins are required for efficient herpes simplex virus 1 replication. Mohni KN, Mastrocola AS, Bai P, Weller SK, Heinen CD. J Virol. 2011 Dec;85(23):12241-53. doi: 10.1128/JVI.05487-11. Epub 2011 Sep 28. PubMed |
| HIF-1alpha and HIF-2alpha degradation is differentially regulated in nucleus pulposus cells of the intervertebral disc. Fujita N, Chiba K, Shapiro IM, Risbud MV. J Bone Miner Res. 2012 Feb;27(2):401-12. doi: 10.1002/jbmr.538. PubMed |
| The asparaginyl hydroxylase factor-inhibiting HIF is essential for tumor growth through suppression of the p53-p21 axis. Pelletier J, Dayan F, Durivault J, Ilc K, Pecou E, Pouyssegur J, Mazure NM. Oncogene. 2012 Jun 14;31(24):2989-3001. doi: 10.1038/onc.2011.471. Epub 2011 Oct 17. PubMed |
| Suppression of BCL-2 synergizes cisplatin sensitivity in nasopharyngeal carcinoma cells. Low SY, Tan BS, Choo HL, Tiong KH, Khoo AS, Leong CO. Cancer Lett. 2012 Jan 28;314(2):166-75. doi: 10.1016/j.canlet.2011.09.025. Epub 2011 Oct 8. PubMed |
| Disruption of Wnt planar cell polarity signaling by aberrant accumulation of the MetAP-2 substrate Rab37. Sundberg TB, Darricarrere N, Cirone P, Li X, McDonald L, Mei X, Westlake CJ, Slusarski DC, Beynon RJ, Crews CM. Chem Biol. 2011 Oct 28;18(10):1300-11. doi: 10.1016/j.chembiol.2011.07.020. PubMed |
| FGF signalling inhibits neural induction in human embryonic stem cells. Greber B, Coulon P, Zhang M, Moritz S, Frank S, Muller-Molina AJ, Arauzo-Bravo MJ, Han DW, Pape HC, Scholer HR. EMBO J. 2011 Nov 15;30(24):4874-84. doi: 10.1038/emboj.2011.407. PubMed |
| Excitation-induced ataxin-3 aggregation in neurons from patients with Machado-Joseph disease. Koch P, Breuer P, Peitz M, Jungverdorben J, Kesavan J, Poppe D, Doerr J, Ladewig J, Mertens J, Tuting T, Hoffmann P, Klockgether T, Evert BO, Wullner U, Brustle O. Nature. 2011 Nov 23;480(7378):543-6. doi: 10.1038/nature10671. PubMed |
| Defining MAP3 kinases required for MDA-MB-231 cell tumor growth and metastasis. Cronan MR, Nakamura K, Johnson NL, Granger DA, Cuevas BD, Wang JG, Mackman N, Scott JE, Dohlman HG, Johnson GL. Oncogene. 2012 Aug 23;31(34):3889-900. doi: 10.1038/onc.2011.544. Epub 2011 Dec 5. PubMed |
| GABAergic circuits mediate the reinforcement-related signals of striatal cholinergic interneurons. English DF, Ibanez-Sandoval O, Stark E, Tecuapetla F, Buzsaki G, Deisseroth K, Tepper JM, Koos T. Nat Neurosci. 2011 Dec 11;15(1):123-30. doi: 10.1038/nn.2984. PubMed |
| Development of immortalized hepatocyte-like cells from hMSCs. Wongkajornsilp A, Sa-Ngiamsuntorn K, Hongeng S. Methods Mol Biol. 2012;826:73-87. doi: 10.1007/978-1-61779-468-1_7. PubMed |
Efficient conversion of astrocytes to functional midbrain dopaminergic neurons using a single polycistronic vector.
Addis RC, Hsu FC, Wright RL, Dichter MA, Coulter DA, Gearhart JD.
PLoS One. 2011;6(12):e28719. doi: 10.1371/journal.pone.0028719. Epub 2011 Dec 9.
PubMed
Associated Plasmids |
Modulation of Wnt/beta-catenin signaling in human embryonic stem cells using a 3-D microwell array.
Azarin SM, Lian X, Larson EA, Popelka HM, de Pablo JJ, Palecek SP.
Biomaterials. 2012 Mar;33(7):2041-9. Epub 2011 Dec 15.
PubMed
Associated Plasmids |
| Pygo2 regulates histone gene expression and H3 K56 acetylation in human mammary epithelial cells. Gu B, Watanabe K, Dai X. Cell Cycle. 2012 Jan 1;11(1):79-87. doi: 10.4161/cc.11.1.18402. Epub 2012 Jan 1. PubMed |
| The role of c-FLIP splice variants in urothelial tumours. Ewald F, Ueffing N, Brockmann L, Hader C, Telieps T, Schuster M, Schulz WA, Schmitz I. Cell Death Dis. 2011 Dec 22;2:e245. doi: 10.1038/cddis.2011.131. PubMed |
| IGF2BP1 promotes cell migration by regulating MK5 and PTEN signaling. Stohr N, Kohn M, Lederer M, Glass M, Reinke C, Singer RH, Huttelmaier S. Genes Dev. 2012 Jan 15;26(2):176-89. doi: 10.1101/gad.177642.111. PubMed |
| The cyclin-like protein Spy1/RINGO promotes mammary transformation and is elevated in human breast cancer. Al Sorkhy M, Ferraiuolo RM, Jalili E, Malysa A, Fratiloiu AR, Sloane BF, Porter LA. BMC Cancer. 2012 Jan 26;12:45. doi: 10.1186/1471-2407-12-45. PubMed |
| The aryl hydrocarbon receptor contributes to the proliferation of human medulloblastoma cells. Dever DP, Opanashuk LA. Mol Pharmacol. 2012 May;81(5):669-78. doi: 10.1124/mol.111.077305. Epub 2012 Feb 6. PubMed |
| Outgrowth of single oncogene-expressing cells from suppressive epithelial environments. Leung CT, Brugge JS. Nature. 2012 Feb 8;482(7385):410-3. doi: 10.1038/nature10826. PubMed |
| Retinoblastoma tumor-suppressor protein phosphorylation and inactivation depend on direct interaction with Pin1. Rizzolio F, Lucchetti C, Caligiuri I, Marchesi I, Caputo M, Klein-Szanto AJ, Bagella L, Castronovo M, Giordano A. Cell Death Differ. 2012 Jul;19(7):1152-61. doi: 10.1038/cdd.2011.202. Epub 2012 Feb 10. PubMed |
| Impairment of lysosomal integrity by B10, a glycosylated derivative of betulinic acid, leads to lysosomal cell death and converts autophagy into a detrimental process. Gonzalez P, Mader I, Tchoghandjian A, Enzenmuller S, Cristofanon S, Basit F, Debatin KM, Fulda S. Cell Death Differ. 2012 Aug;19(8):1337-46. doi: 10.1038/cdd.2012.10. Epub 2012 Feb 17. PubMed |
| Angiogenic properties of myofibroblasts isolated from normal human skin wounds. Mayrand D, Laforce-Lavoie A, Larochelle S, Langlois A, Genest H, Roy M, Moulin VJ. Angiogenesis. 2012 Jun;15(2):199-212. doi: 10.1007/s10456-012-9253-5. Epub 2012 Feb 18. PubMed |
| Real-time bioluminescence and tomographic imaging of gastric cancer in a novel orthotopic mouse model. Hu H, Liu J, Yao L, Yin J, Su N, Liu X, Cao F, Liang J, Nie Y, Wu K. Oncol Rep. 2012 Jun;27(6):1937-43. doi: 10.3892/or.2012.1713. Epub 2012 Mar 7. PubMed |
| Expression of prolyl hydroxylases (PHDs) is selectively controlled by HIF-1 and HIF-2 proteins in nucleus pulposus cells of the intervertebral disc: distinct roles of PHD2 and PHD3 proteins in controlling HIF-1alpha activity in hypoxia. Fujita N, Markova D, Anderson DG, Chiba K, Toyama Y, Shapiro IM, Risbud MV. J Biol Chem. 2012 May 11;287(20):16975-86. doi: 10.1074/jbc.M111.334466. Epub 2012 Mar 26. PubMed |
| Pathogen-induced human TH17 cells produce IFN-gamma or IL-10 and are regulated by IL-1beta. Zielinski CE, Mele F, Aschenbrenner D, Jarrossay D, Ronchi F, Gattorno M, Monticelli S, Lanzavecchia A, Sallusto F. Nature. 2012 Apr 26;484(7395):514-8. doi: 10.1038/nature10957. PubMed |
| IL1beta induces mesenchymal stem cells migration and leucocyte chemotaxis through NF-kappaB. Carrero R, Cerrada I, Lledo E, Dopazo J, Garcia-Garcia F, Rubio MP, Trigueros C, Dorronsoro A, Ruiz-Sauri A, Montero JA, Sepulveda P. Stem Cell Rev. 2012 Sep;8(3):905-16. doi: 10.1007/s12015-012-9364-9. PubMed |
| Heightened expression of MICA enhances the cytotoxicity of NK cells or CD8+T cells to human corneal epithelium in vitro. Hong J, Qiu T, Qian T, Li G, Yu X, Chen J, Le Q, Sun X, Xu J. BMC Ophthalmol. 2012 Apr 4;12:6. doi: 10.1186/1471-2415-12-6. PubMed |
| RGB marking with lentiviral vectors for multicolor clonal cell tracking. Weber K, Thomaschewski M, Benten D, Fehse B. Nat Protoc. 2012 Apr 5;7(5):839-49. doi: 10.1038/nprot.2012.026. PubMed |
| Zfp296 is a novel, pluripotent-specific reprogramming factor. Fischedick G, Klein DC, Wu G, Esch D, Hoing S, Han DW, Reinhardt P, Hergarten K, Tapia N, Scholer HR, Sterneckert JL. PLoS One. 2012;7(4):e34645. doi: 10.1371/journal.pone.0034645. Epub 2012 Apr 2. PubMed |
| Human-induced pluripotent stem cells form functional neurons and improve recovery after grafting in stroke-damaged brain. Oki K, Tatarishvili J, Wood J, Koch P, Wattananit S, Mine Y, Monni E, Tornero D, Ahlenius H, Ladewig J, Brustle O, Lindvall O, Kokaia Z. Stem Cells. 2012 Jun;30(6):1120-33. doi: 10.1002/stem.1104. PubMed |
| Carbonic anhydrase III regulates peroxisome proliferator-activated receptor-gamma2. Mitterberger MC, Kim G, Rostek U, Levine RL, Zwerschke W. Exp Cell Res. 2012 May 1;318(8):877-86. doi: 10.1016/j.yexcr.2012.02.011. Epub 2012 Feb 28. PubMed |
| Myosin Ia is required for CFTR brush border membrane trafficking and ion transport in the mouse small intestine. Kravtsov DV, Caputo C, Collaco A, Hoekstra N, Egan ME, Mooseker MS, Ameen NA. Traffic. 2012 Aug;13(8):1072-82. doi: 10.1111/j.1600-0854.2012.01368.x. Epub 2012 May 8. PubMed |
| Nanotopography as modulator of human mesenchymal stem cell function. Kulangara K, Yang Y, Yang J, Leong KW. Biomaterials. 2012 Jul;33(20):4998-5003. doi: 10.1016/j.biomaterials.2012.03.053. Epub 2012 Apr 18. PubMed |
| Aire promotes the self-renewal of embryonic stem cells through Lin28. Bin G, Jiarong Z, Shihao W, Xiuli S, Cheng X, Liangbiao C, Ming Z. Stem Cells Dev. 2012 Oct 10;21(15):2878-90. doi: 10.1089/scd.2012.0097. Epub 2012 Jun 11. PubMed |
Identification of the human PMR1 mRNA endonuclease as an alternatively processed product of the gene for peroxidasin-like protein.
Gu SQ, Bakthavachalu B, Han J, Patil DP, Otsuka Y, Guda C, Schoenberg DR.
RNA. 2012 Jun;18(6):1186-96. doi: 10.1261/rna.031369.111. Epub 2012 Apr 27.
PubMed
Associated Plasmids |
| LASS2 enhances chemosensitivity of breast cancer by counteracting acidic tumor microenvironment through inhibiting activity of V-ATPase proton pump. Fan S, Niu Y, Tan N, Wu Z, Wang Y, You H, Ke R, Song J, Shen Q, Wang W, Yao G, Shu H, Lin H, Yao M, Zhang Z, Gu J, Qin W. Oncogene. 2013 Mar 28;32(13):1682-90. doi: 10.1038/onc.2012.183. Epub 2012 May 14. PubMed |
| Identification of novel human damage response proteins targeted through yeast orthology. Svensson JP, Fry RC, Wang E, Somoza LA, Samson LD. PLoS One. 2012;7(5):e37368. doi: 10.1371/journal.pone.0037368. Epub 2012 May 16. PubMed |
| DLK1(PREF1) is a negative regulator of adipogenesis in CD105(+)/CD90(+)/CD34(+)/CD31(-)/FABP4(-) adipose-derived stromal cells from subcutaneous abdominal fat pats of adult women. Mitterberger MC, Lechner S, Mattesich M, Kaiser A, Probst D, Wenger N, Pierer G, Zwerschke W. Stem Cell Res. 2012 Jul;9(1):35-48. doi: 10.1016/j.scr.2012.04.001. Epub 2012 Apr 17. PubMed |
| Smad3 controls beta-1,3-glucuronosyltransferase 1 expression in rat nucleus pulposus cells: implications of dysregulated expression in disc disease. Wu Q, Wang J, Skubutyte R, Kepler CK, Huang Z, Anderson DG, Shapiro IM, Risbud MV. Arthritis Rheum. 2012 Oct;64(10):3324-33. doi: 10.1002/art.34570. PubMed |
| Morphology of axonal projections from the high vocal center to vocal motor cortex in songbirds. Yip ZC, Miller-Sims VC, Bottjer SW. J Comp Neurol. 2012 Aug 15;520(12):2742-56. doi: 10.1002/cne.23084. PubMed |
| gamma-Secretase inhibition promotes cell death, Noxa upregulation, and sensitization to BH3 mimetic ABT-737 in human breast cancer cells. Seveno C, Loussouarn D, Brechet S, Campone M, Juin P, Barille-Nion S. Breast Cancer Res. 2012 Jun 15;14(3):R96. PubMed |
| A versatile lentiviral expression system to identify mammalian protein-protein interactions. Mak AB, Moffat J. Methods. 2012 Aug;57(4):409-16. doi: 10.1016/j.ymeth.2012.06.005. Epub 2012 Jun 17. PubMed |
| Inverted Alu dsRNA structures do not affect localization but can alter translation efficiency of human mRNAs independent of RNA editing. Capshew CR, Dusenbury KL, Hundley HA. Nucleic Acids Res. 2012 Sep 1;40(17):8637-45. Epub 2012 Jun 25. PubMed |
| Iterative capped assembly: rapid and scalable synthesis of repeat-module DNA such as TAL effectors from individual monomers. Briggs AW, Rios X, Chari R, Yang L, Zhang F, Mali P, Church GM. Nucleic Acids Res. 2012 Aug;40(15):e117. doi: 10.1093/nar/gks624. Epub 2012 Jun 26. PubMed |
| Fibroblast-secreted hepatocyte growth factor mediates epidermal growth factor receptor tyrosine kinase inhibitor resistance in triple-negative breast cancers through paracrine activation of Met. Mueller KL, Madden JM, Zoratti GL, Kuperwasser C, List K, Boerner JL. Breast Cancer Res. 2012 Jul 12;14(4):R104. doi: 10.1186/bcr3224. PubMed |
| Role of mismatch repair enzymes in GAA.TTC triplet-repeat expansion in Friedreich ataxia induced pluripotent stem cells. Du J, Campau E, Soragni E, Ku S, Puckett JW, Dervan PB, Gottesfeld JM. J Biol Chem. 2012 Aug 24;287(35):29861-72. doi: 10.1074/jbc.M112.391961. Epub 2012 Jul 13. PubMed |
| Expression of the PTTG1 oncogene is associated with aggressive clear cell renal cell carcinoma. Wondergem B, Zhang Z, Huang D, Ong CK, Koeman J, Hof DV, Petillo D, Ooi A, Anema J, Lane B, Kahnoski RJ, Furge KA, Teh BT. Cancer Res. 2012 Sep 1;72(17):4361-71. doi: 10.1158/0008-5472.CAN-11-2330. Epub 2012 Jul 17. PubMed |
| Cytokine secretion by CD4+ T cells at the immunological synapse requires Cdc42-dependent local actin remodeling but not microtubule organizing center polarity. Chemin K, Bohineust A, Dogniaux S, Tourret M, Guegan S, Miro F, Hivroz C. J Immunol. 2012 Sep 1;189(5):2159-68. doi: 10.4049/jimmunol.1200156. Epub 2012 Jul 20. PubMed |
| ASC-dependent RIP2 kinase regulates reduced PGE2 production in chronic periodontitis. Taxman DJ, Lei Y, Zhang S, Holley-Guthrie E, Offenbacher S, Ting JP. J Dent Res. 2012 Sep;91(9):877-82. doi: 10.1177/0022034512454541. Epub 2012 Jul 24. PubMed |
| Synthesis and evaluation of hybrid drugs for a potential HIV/AIDS-malaria combination therapy. Aminake MN, Mahajan A, Kumar V, Hans R, Wiesner L, Taylor D, de Kock C, Grobler A, Smith PJ, Kirschner M, Rethwilm A, Pradel G, Chibale K. Bioorg Med Chem. 2012 Sep 1;20(17):5277-89. doi: 10.1016/j.bmc.2012.06.038. Epub 2012 Jun 29. PubMed |
| Genetic background affects induced pluripotent stem cell generation. Schnabel LV, Abratte CM, Schimenti JC, Southard TL, Fortier LA. Stem Cell Res Ther. 2012 Aug 3;3(4):30. doi: 10.1186/scrt121. PubMed |
| Inhibiting adipose tissue lipogenesis reprograms thermogenesis and PPARgamma activation to decrease diet-induced obesity. Lodhi IJ, Yin L, Jensen-Urstad AP, Funai K, Coleman T, Baird JH, El Ramahi MK, Razani B, Song H, Fu-Hsu F, Turk J, Semenkovich CF. Cell Metab. 2012 Aug 8;16(2):189-201. PubMed |
| Autophagy is a protective response to ethanol neurotoxicity. Chen G, Ke Z, Xu M, Liao M, Wang X, Qi Y, Zhang T, Frank JA, Bower KA, Shi X, Luo J. Autophagy. 2012 Nov;8(11):1577-89. doi: 10.4161/auto.21376. Epub 2012 Aug 9. PubMed |
| Androgen receptor serine 81 mediates Pin1 interaction and activity. La Montagna R, Caligiuri I, Maranta P, Lucchetti C, Esposito L, Paggi MG, Toffoli G, Rizzolio F, Giordano A. Cell Cycle. 2012 Sep 15;11(18):3415-20. doi: 10.4161/cc.21730. Epub 2012 Aug 16. PubMed |
| Elevating SOX2 levels deleteriously affects the growth of medulloblastoma and glioblastoma cells. Cox JL, Wilder PJ, Desler M, Rizzino A. PLoS One. 2012;7(8):e44087. doi: 10.1371/journal.pone.0044087. Epub 2012 Aug 28. PubMed |
| Prolyl hydroxylase 3 (PHD3) modulates catabolic effects of tumor necrosis factor-alpha (TNF-alpha) on cells of the nucleus pulposus through co-activation of nuclear factor kappaB (NF-kappaB)/p65 signaling. Fujita N, Gogate SS, Chiba K, Toyama Y, Shapiro IM, Risbud MV. J Biol Chem. 2012 Nov 16;287(47):39942-53. doi: 10.1074/jbc.M112.375964. Epub 2012 Sep 4. PubMed |
| Autophagy plays a protective role in endoplasmic reticulum stress-mediated pancreatic beta cell death. Bartolome A, Guillen C, Benito M. Autophagy. 2012 Dec;8(12):1757-68. doi: 10.4161/auto.21994. Epub 2012 Sep 5. PubMed |
| Mouse models for tumor metastasis. Yang S, Zhang JJ, Huang XY. Methods Mol Biol. 2012;928:221-8. doi: 10.1007/978-1-62703-008-3_17. PubMed |
| AIF-mediated caspase-independent necroptosis requires ATM and DNA-PK-induced histone H2AX Ser139 phosphorylation. Baritaud M, Cabon L, Delavallee L, Galan-Malo P, Gilles ME, Brunelle-Navas MN, Susin SA. Cell Death Dis. 2012 Sep 13;3:e390. doi: 10.1038/cddis.2012.120. PubMed |
| Mechanism of capsaicin receptor TRPV1-mediated toxicity in pain-sensing neurons focusing on the effects of Na(+)/Ca(2+) fluxes and the Ca(2+)-binding protein calretinin. Pecze L, Blum W, Schwaller B. Biochim Biophys Acta. 2013 Jul;1833(7):1680-91. doi: 10.1016/j.bbamcr.2012.08.018. Epub 2012 Sep 5. PubMed |
| The ablation of EZH2 uncovers its crucial role in rhabdomyosarcoma formation. Marchesi I, Fiorentino FP, Rizzolio F, Giordano A, Bagella L. Cell Cycle. 2012 Oct 15;11(20):3828-36. doi: 10.4161/cc.22025. Epub 2012 Sep 14. PubMed |
p53 mutation alters the effect of the esophageal tumor suppressor KLF5 on keratinocyte proliferation.
Yang Y, Tarapore RS, Jarmel MH, Tetreault MP, Katz JP.
Cell Cycle. 2012 Nov 1;11(21):4033-9. doi: 10.4161/cc.22265. Epub 2012 Sep 18.
PubMed
Associated Plasmids |
| Calcium-permeable alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors trigger neuronal nitric-oxide synthase activation to promote nerve cell death in an Src kinase-dependent fashion. Socodato R, Santiago FN, Portugal CC, Domingues AF, Santiago AR, Relvas JB, Ambrosio AF, Paes-de-Carvalho R. J Biol Chem. 2012 Nov 9;287(46):38680-94. doi: 10.1074/jbc.M112.353961. Epub 2012 Sep 19. PubMed |
| Codon-usage-based inhibition of HIV protein synthesis by human schlafen 11. Li M, Kao E, Gao X, Sandig H, Limmer K, Pavon-Eternod M, Jones TE, Landry S, Pan T, Weitzman MD, David M. Nature. 2012 Nov 1;491(7422):125-8. doi: 10.1038/nature11433. Epub 2012 Sep 23. PubMed |
| The cellular ataxia telangiectasia-mutated kinase promotes epstein-barr virus lytic reactivation in response to multiple different types of lytic reactivation-inducing stimuli. Hagemeier SR, Barlow EA, Meng Q, Kenney SC. J Virol. 2012 Dec;86(24):13360-70. doi: 10.1128/JVI.01850-12. Epub 2012 Sep 26. PubMed |
| Low molecular weight dextran sulfate binds to human myoblasts and improves their survival after transplantation in mice. Laumonier T, Pradier A, Hoffmeyer P, Kindler V, Menetrey J. Cell Transplant. 2013;22(7):1213-26. doi: 10.3727/096368912X657224. Epub 2012 Oct 1. PubMed |
| Synergistic antitumor effects of endostar in combination with oxaliplatin via inhibition of HIF and CXCR4 in the colorectal cell line SW1116. Jin F, Ji H, Jia C, Brockmeier U, Hermann DM, Metzen E, Zhu Y, Chi B. PLoS One. 2012;7(10):e47161. doi: 10.1371/journal.pone.0047161. Epub 2012 Oct 10. PubMed |
| Defining Akt actions in muscle differentiation. Gardner S, Anguiano M, Rotwein P. Am J Physiol Cell Physiol. 2012 Dec 15;303(12):C1292-300. doi: 10.1152/ajpcell.00259.2012. Epub 2012 Oct 17. PubMed |
| Functional analysis of in-frame indel ARID1A mutations reveals new regulatory mechanisms of its tumor suppressor functions. Guan B, Gao M, Wu CH, Wang TL, Shih IeM. Neoplasia. 2012 Oct;14(10):986-93. PubMed |
| Influenza virus induces apoptosis via BAD-mediated mitochondrial dysregulation. Tran AT, Cortens JP, Du Q, Wilkins JA, Coombs KM. J Virol. 2013 Jan;87(2):1049-60. doi: 10.1128/JVI.02017-12. Epub 2012 Nov 7. PubMed |
| Loss of NF1 expression in human endothelial cells promotes autonomous proliferation and altered vascular morphogenesis. Bajaj A, Li QF, Zheng Q, Pumiglia K. PLoS One. 2012;7(11):e49222. doi: 10.1371/journal.pone.0049222. Epub 2012 Nov 7. PubMed |
| Impact of sustained RNAi-mediated suppression of cellular cofactor Tat-SF1 on HIV-1 replication in CD4+ T cells. Green VA, Arbuthnot P, Weinberg MS. Virol J. 2012 Nov 15;9:272. doi: 10.1186/1743-422X-9-272. PubMed |
| Comparison of mixed and lamellar coculture spatial arrangements for tissue engineering capillary networks in vitro. Peters EB, Christoforou N, Leong KW, Truskey GA. Tissue Eng Part A. 2013 Mar;19(5-6):697-706. doi: 10.1089/ten.tea.2011.0704. Epub 2012 Nov 21. PubMed |
| Role of early B-cell factor 1 (EBF1) in Hodgkin lymphoma. Bohle V, Doring C, Hansmann ML, Kuppers R. Leukemia. 2013 Mar;27(3):671-9. doi: 10.1038/leu.2012.280. Epub 2012 Oct 1. PubMed |
| Insulin inhibits cardiac mesoderm, not mesendoderm, formation during cardiac differentiation of human pluripotent stem cells and modulation of canonical Wnt signaling can rescue this inhibition. Lian X, Zhang J, Zhu K, Kamp TJ, Palecek SP. Stem Cells. 2013 Mar;31(3):447-57. doi: 10.1002/stem.1289. PubMed |
| Alpharetroviral vector-mediated gene therapy for X-CGD: functional correction and lack of aberrant splicing. Kaufmann KB, Brendel C, Suerth JD, Mueller-Kuller U, Chen-Wichmann L, Schwable J, Pahujani S, Kunkel H, Schambach A, Baum C, Grez M. Mol Ther. 2013 Mar;21(3):648-61. doi: 10.1038/mt.2012.249. Epub 2012 Dec 4. PubMed |
| Tissue-specific interaction of Per1/2 and Dec2 in the regulation of fibroblast circadian rhythms. Tsang AH, Sanchez-Moreno C, Bode B, Rossner MJ, Garaulet M, Oster H. J Biol Rhythms. 2012 Dec;27(6):478-89. doi: 10.1177/0748730412462838. PubMed |
| Tumor necrosis factor alpha- and interleukin-1beta-dependent induction of CCL3 expression by nucleus pulposus cells promotes macrophage migration through CCR1. Wang J, Tian Y, Phillips KL, Chiverton N, Haddock G, Bunning RA, Cross AK, Shapiro IM, Le Maitre CL, Risbud MV. Arthritis Rheum. 2013 Mar;65(3):832-42. doi: 10.1002/art.37819. PubMed |
| Directed cardiomyocyte differentiation from human pluripotent stem cells by modulating Wnt/beta-catenin signaling under fully defined conditions. Lian X, Zhang J, Azarin SM, Zhu K, Hazeltine LB, Bao X, Hsiao C, Kamp TJ, Palecek SP. Nat Protoc. 2013 Jan;8(1):162-75. doi: 10.1038/nprot.2012.150. Epub 2012 Dec 20. PubMed |
| Ribosomal protein S25 dependency reveals a common mechanism for diverse internal ribosome entry sites and ribosome shunting. Hertz MI, Landry DM, Willis AE, Luo G, Thompson SR. Mol Cell Biol. 2013 Mar;33(5):1016-26. doi: 10.1128/MCB.00879-12. Epub 2012 Dec 28. PubMed |
| RNA-interacting proteins act as site-specific repressors of ADAR2-mediated RNA editing and fluctuate upon neuronal stimulation. Tariq A, Garncarz W, Handl C, Balik A, Pusch O, Jantsch MF. Nucleic Acids Res. 2013 Feb 1;41(4):2581-93. doi: 10.1093/nar/gks1353. Epub 2012 Dec 28. PubMed |
| Gene-specific factors determine mitotic expression and bookmarking via alternate regulatory elements. Arampatzi P, Gialitakis M, Makatounakis T, Papamatheakis J. Nucleic Acids Res. 2013 Feb 1;41(4):2202-15. doi: 10.1093/nar/gks1365. Epub 2013 Jan 8. PubMed |
| Role of C/EBPbeta-LAP and C/EBPbeta-LIP in early adipogenic differentiation of human white adipose-derived progenitors and at later stages in immature adipocytes. Lechner S, Mitterberger MC, Mattesich M, Zwerschke W. Differentiation. 2013 Jan;85(1-2):20-31. doi: 10.1016/j.diff.2012.11.001. Epub 2013 Jan 11. PubMed |
| RNAi-mediated gene function analysis in skin. Beronja S, Fuchs E. Methods Mol Biol. 2013;961:351-61. doi: 10.1007/978-1-62703-227-8_23. PubMed |
| An analysis and validation pipeline for large-scale RNAi-based screens. Plank M, Hu G, Silva AS, Wood SH, Hesketh EE, Janssens G, Macedo A, de Magalhaes JP, Church GM. Sci Rep. 2013;3:1076. doi: 10.1038/srep01076. Epub 2013 Jan 16. PubMed |
| Nonviral direct conversion of primary mouse embryonic fibroblasts to neuronal cells. Adler AF, Grigsby CL, Kulangara K, Wang H, Yasuda R, Leong KW. Mol Ther Nucleic Acids. 2012 Jul 10;1:e32. doi: 10.1038/mtna.2012.25. PubMed |
| alpha-Synuclein membrane association is regulated by the Rab3a recycling machinery and presynaptic activity. Chen RH, Wislet-Gendebien S, Samuel F, Visanji NP, Zhang G, Marsilio D, Langman T, Fraser PE, Tandon A. J Biol Chem. 2013 Mar 15;288(11):7438-49. doi: 10.1074/jbc.M112.439497. Epub 2013 Jan 23. PubMed |
| A high-throughput screen to identify enhancers of ADAR-mediated RNA-editing. Garncarz W, Tariq A, Handl C, Pusch O, Jantsch MF. RNA Biol. 2013 Feb;10(2):192-204. doi: 10.4161/rna.23208. Epub 2013 Jan 25. PubMed |
| Identification of CDCP1 as a hypoxia-inducible factor 2alpha (HIF-2alpha) target gene that is associated with survival in clear cell renal cell carcinoma patients. Emerling BM, Benes CH, Poulogiannis G, Bell EL, Courtney K, Liu H, Choo-Wing R, Bellinger G, Tsukazawa KS, Brown V, Signoretti S, Soltoff SP, Cantley LC. Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3483-8. doi: 10.1073/pnas.1222435110. Epub 2013 Feb 1. PubMed |
| Hypertonic stress promotes autophagy and microtubule-dependent autophagosomal clusters. Nunes P, Ernandez T, Roth I, Qiao X, Strebel D, Bouley R, Charollais A, Ramadori P, Foti M, Meda P, Feraille E, Brown D, Hasler U. Autophagy. 2013 Apr;9(4):550-67. doi: 10.4161/auto.23662. Epub 2013 Feb 4. PubMed |
| The prolyl isomerase Pin1 acts synergistically with CDK2 to regulate the basal activity of estrogen receptor alpha in breast cancer. Lucchetti C, Caligiuri I, Toffoli G, Giordano A, Rizzolio F. PLoS One. 2013;8(2):e55355. doi: 10.1371/journal.pone.0055355. Epub 2013 Feb 4. PubMed |
| CD44 is involved in mineralization of dental pulp cells. Chen KL, Huang YY, Lung J, Yeh YY, Yuan K. J Endod. 2013 Mar;39(3):351-6. doi: 10.1016/j.joen.2012.11.043. Epub 2013 Jan 16. PubMed |
| Identification of tribbles-1 as a novel binding partner of Foxp3 in regulatory T cells. Dugast E, Kiss-Toth E, Docherty L, Danger R, Chesneau M, Pichard V, Judor JP, Pettre S, Conchon S, Soulillou JP, Brouard S, Ashton-Chess J. J Biol Chem. 2013 Apr 5;288(14):10051-60. doi: 10.1074/jbc.M112.448654. Epub 2013 Feb 15. PubMed |
| GRB2-mediated recruitment of THEMIS to LAT is essential for thymocyte development. Paster W, Brockmeyer C, Fu G, Simister PC, de Wet B, Martinez-Riano A, Hoerter JA, Feller SM, Wulfing C, Gascoigne NR, Acuto O. J Immunol. 2013 Apr 1;190(7):3749-56. doi: 10.4049/jimmunol.1203389. Epub 2013 Mar 4. PubMed |
| Canonical Wnt signaling induces BMP-4 to specify slow myofibrogenesis of fetal myoblasts. Kuroda K, Kuang S, Taketo MM, Rudnicki MA. Skelet Muscle. 2013 Mar 5;3(1):5. doi: 10.1186/2044-5040-3-5. PubMed |
| Hypoxia-inducible factor (HIF)-1alpha and CCN2 form a regulatory circuit in hypoxic nucleus pulposus cells: CCN2 suppresses HIF-1alpha level and transcriptional activity. Tran CM, Fujita N, Huang BL, Ong JR, Lyons KM, Shapiro IM, Risbud MV. J Biol Chem. 2013 May 3;288(18):12654-66. doi: 10.1074/jbc.M112.448860. Epub 2013 Mar 24. PubMed |
| The ULb' region of the human cytomegalovirus genome confers an increased requirement for the viral protein kinase UL97. Wang D, Li G, Schauflinger M, Nguyen CC, Hall ED, Yurochko AD, von Einem J, Kamil JP. J Virol. 2013 Jun;87(11):6359-76. doi: 10.1128/JVI.03477-12. Epub 2013 Mar 27. PubMed |
| Sigma-1 receptor regulates early steps of viral RNA replication at the onset of hepatitis C virus infection. Friesland M, Mingorance L, Chung J, Chisari FV, Gastaminza P. J Virol. 2013 Jun;87(11):6377-90. doi: 10.1128/JVI.03557-12. Epub 2013 Mar 27. PubMed |
| A systematic approach to the establishment and characterization of endothelial progenitor cells for gene therapy. Werling NJ, Thorpe R, Zhao Y. Hum Gene Ther Methods. 2013 Jun;24(3):171-84. doi: 10.1089/hgtb.2012.146. Epub 2013 Apr 30. PubMed |
| Nutrient-dependent phosphorylation channels lipid synthesis to regulate PPARalpha. Jensen-Urstad AP, Song H, Lodhi IJ, Funai K, Yin L, Coleman T, Semenkovich CF. J Lipid Res. 2013 Jul;54(7):1848-59. doi: 10.1194/jlr.M036103. Epub 2013 Apr 13. PubMed |
| DISC1-ATF4 transcriptional repression complex: dual regulation of the cAMP-PDE4 cascade by DISC1. Soda T, Frank C, Ishizuka K, Baccarella A, Park YU, Flood Z, Park SK, Sawa A, Tsai LH. Mol Psychiatry. 2013 Aug;18(8):898-908. doi: 10.1038/mp.2013.38. Epub 2013 Apr 16. PubMed |
| Inflammatory cytokines induce NOTCH signaling in nucleus pulposus cells: implications in intervertebral disc degeneration. Wang H, Tian Y, Wang J, Phillips KL, Binch AL, Dunn S, Cross A, Chiverton N, Zheng Z, Shapiro IM, Le Maitre CL, Risbud MV. J Biol Chem. 2013 Jun 7;288(23):16761-74. doi: 10.1074/jbc.M112.446633. Epub 2013 Apr 15. PubMed |
Optimization of direct fibroblast reprogramming to cardiomyocytes using calcium activity as a functional measure of success.
Addis RC, Ifkovits JL, Pinto F, Kellam LD, Esteso P, Rentschler S, Christoforou N, Epstein JA, Gearhart JD.
J Mol Cell Cardiol. 2013 Apr 13;60C:97-106. doi: 10.1016/j.yjmcc.2013.04.004.
PubMed
Associated Plasmids |
| Lipid droplet-binding protein TIP47 regulates hepatitis C Virus RNA replication through interaction with the viral NS5A protein. Vogt DA, Camus G, Herker E, Webster BR, Tsou CL, Greene WC, Yen TS, Ott M. PLoS Pathog. 2013;9(4):e1003302. doi: 10.1371/journal.ppat.1003302. Epub 2013 Apr 11. PubMed |
| Calretinin is essential for mesothelioma cell growth/survival in vitro: a potential new target for malignant mesothelioma therapy? Blum W, Schwaller B. Int J Cancer. 2013 Nov;133(9):2077-88. doi: 10.1002/ijc.28218. Epub 2013 Jul 9. PubMed |
| Inflammatory cytokines associated with degenerative disc disease control aggrecanase-1 (ADAMTS-4) expression in nucleus pulposus cells through MAPK and NF-kappaB. Tian Y, Yuan W, Fujita N, Wang J, Wang H, Shapiro IM, Risbud MV. Am J Pathol. 2013 Jun;182(6):2310-21. doi: 10.1016/j.ajpath.2013.02.037. Epub 2013 Apr 17. PubMed |
| 6-Shogaol inhibits breast and colon cancer cell proliferation through activation of peroxisomal proliferator activated receptor gamma (PPARgamma). Tan BS, Kang O, Mai CW, Tiong KH, Khoo AS, Pichika MR, Bradshaw TD, Leong CO. Cancer Lett. 2013 Aug 9;336(1):127-39. doi: 10.1016/j.canlet.2013.04.014. Epub 2013 Apr 21. PubMed |
| Evidence for tankyrases as antineoplastic targets in lung cancer. Busch AM, Johnson KC, Stan RV, Sanglikar A, Ahmed Y, Dmitrovsky E, Freemantle SJ. BMC Cancer. 2013 Apr 28;13:211. doi: 10.1186/1471-2407-13-211. PubMed |
| Prox1 directly interacts with LSD1 and recruits the LSD1/NuRD complex to epigenetically co-repress CYP7A1 transcription. Ouyang H, Qin Y, Liu Y, Xie Y, Liu J. PLoS One. 2013 Apr 23;8(4):e62192. doi: 10.1371/journal.pone.0062192. Print 2013. PubMed |
| Efficacious proteasome/HDAC inhibitor combination therapy for primary effusion lymphoma. Bhatt S, Ashlock BM, Toomey NL, Diaz LA, Mesri EA, Lossos IS, Ramos JC. J Clin Invest. 2013 Jun;123(6):2616-28. doi: 10.1172/JCI64503. Epub 2013 May 1. PubMed |
| BAG3 induction is required to mitigate proteotoxicity via selective autophagy following inhibition of constitutive protein degradation pathways. Rapino F, Jung M, Fulda S. Oncogene. 2014 Mar 27;33(13):1713-24. doi: 10.1038/onc.2013.110. Epub 2013 May 6. PubMed |
| Dyskeratosis congenita mutations in dyskerin SUMOylation consensus sites lead to impaired telomerase RNA accumulation and telomere defects. Brault ME, Lauzon C, Autexier C. Hum Mol Genet. 2013 Sep 1;22(17):3498-507. doi: 10.1093/hmg/ddt204. Epub 2013 May 8. PubMed |
| The B-cell-specific transcription factor and master regulator Pax5 promotes Epstein-Barr virus latency by negatively regulating the viral immediate early protein BZLF1. Raver RM, Panfil AR, Hagemeier SR, Kenney SC. J Virol. 2013 Jul;87(14):8053-63. doi: 10.1128/JVI.00546-13. Epub 2013 May 15. PubMed |
| Keratins control intercellular adhesion involving PKC-alpha-mediated desmoplakin phosphorylation. Kroger C, Loschke F, Schwarz N, Windoffer R, Leube RE, Magin TM. J Cell Biol. 2013 May 27;201(5):681-92. doi: 10.1083/jcb.201208162. Epub 2013 May 20. PubMed |
| Isolation, genetic manipulation, and transplantation of canine spermatogonial stem cells: progress toward transgenesis through the male germ-line. Harkey MA, Asano A, Zoulas ME, Torok-Storb B, Nagashima J, Travis A. Reproduction. 2013 Jun 14;146(1):75-90. doi: 10.1530/REP-13-0086. Print 2013 Jul. PubMed |
| Increased mutagenic joining of enzymatically-induced DNA double-strand breaks in high-charge and energy particle irradiated human cells. Li Z, Hudson FZ, Wang H, Wang Y, Bian Z, Murnane JP, Dynan WS. Radiat Res. 2013 Jul;180(1):17-24. doi: 10.1667/RR3332.1. Epub 2013 May 21. PubMed |
| Focal adhesion kinase is required for IGF-I-mediated growth of skeletal muscle cells via a TSC2/mTOR/S6K1-associated pathway. Crossland H, Kazi AA, Lang CH, Timmons JA, Pierre P, Wilkinson DJ, Smith K, Szewczyk NJ, Atherton PJ. Am J Physiol Endocrinol Metab. 2013 Jul 15;305(2):E183-93. doi: 10.1152/ajpendo.00541.2012. Epub 2013 May 21. PubMed |
| A robust strategy for negative selection of Cre-loxP recombination-based excision of transgenes in induced pluripotent stem cells. Chakraborty S, Christoforou N, Fattahi A, Herzog RW, Leong KW. PLoS One. 2013 May 22;8(5):e64342. doi: 10.1371/journal.pone.0064342. Print 2013. PubMed |
| Inhibiting Polo-like kinase 1 causes growth reduction and apoptosis in pediatric acute lymphoblastic leukemia cells. Hartsink-Segers SA, Exalto C, Allen M, Williamson D, Clifford SC, Horstmann M, Caron HN, Pieters R, Den Boer ML. Haematologica. 2013 Oct;98(10):1539-46. doi: 10.3324/haematol.2013.084434. Epub 2013 Jun 10. PubMed |
| Oxidative stress inhibits adhesion and transendothelial migration, and induces apoptosis and senescence of induced pluripotent stem cells. Wu Y, Zhang X, Kang X, Li N, Wang R, Hu T, Xiang M, Wang X, Yuan W, Chen A, Meng D, Chen S. Clin Exp Pharmacol Physiol. 2013 Sep;40(9):626-34. doi: 10.1111/1440-1681.12141. PubMed |
| Chemerin neutralization blocks hematopoietic stem cell osteoclastogenesis. Muruganandan S, Dranse HJ, Rourke JL, McMullen NM, Sinal CJ. Stem Cells. 2013 Oct;31(10):2172-82. doi: 10.1002/stem.1450. PubMed |
| The pluripotency factor nanog promotes breast cancer tumorigenesis and metastasis. Lu X, Mazur SJ, Lin T, Appella E, Xu Y. Oncogene. 2014 May 15;33(20):2655-64. doi: 10.1038/onc.2013.209. Epub 2013 Jun 17. PubMed |
| A loss-of-function screen for phosphatases that regulate neurite outgrowth identifies PTPN12 as a negative regulator of TrkB tyrosine phosphorylation. Ambjorn M, Dubreuil V, Miozzo F, Nigon F, Moller B, Issazadeh-Navikas S, Berg J, Lees M, Sap J. PLoS One. 2013 Jun 13;8(6):e65371. doi: 10.1371/journal.pone.0065371. Print 2013. PubMed |
| Fibulin-2 is a driver of malignant progression in lung adenocarcinoma. Baird BN, Schliekelman MJ, Ahn YH, Chen Y, Roybal JD, Gill BJ, Mishra DK, Erez B, O'Reilly M, Yang Y, Patel M, Liu X, Thilaganathan N, Larina IV, Dickinson ME, West JL, Gibbons DL, Liu DD, Kim MP, Hicks JM, Wistuba II, Hanash SM, Kurie JM. PLoS One. 2013 Jun 10;8(6):e67054. doi: 10.1371/journal.pone.0067054. Print 2013. PubMed |
| Technical advance: actin CytoFRET, a novel FRET flow cytometry method for detection of actin dynamics in resting and activated T cell. Larbret F, Dubois N, Brau F, Guillemot E, Mahiddine K, Tartare-Deckert S, Verhasselt V, Deckert M. J Leukoc Biol. 2013 Sep;94(3):531-9. doi: 10.1189/jlb.0113022. Epub 2013 Jun 21. PubMed |
| Cyclin-dependent kinase 1-dependent phosphorylation of cAMP response element-binding protein decreases chromatin occupancy. Trinh AT, Kim SH, Chang HY, Mastrocola AS, Tibbetts RS. J Biol Chem. 2013 Aug 16;288(33):23765-75. doi: 10.1074/jbc.M113.464057. Epub 2013 Jun 27. PubMed |
| NGF upregulates the plasminogen activation inhibitor-1 in neurons via the calcineurin/NFAT pathway and the Down syndrome-related proteins DYRK1A and RCAN1 attenuate this effect. Stefos GC, Soppa U, Dierssen M, Becker W. PLoS One. 2013 Jun 25;8(6):e67470. doi: 10.1371/journal.pone.0067470. Print 2013. PubMed |
| Application of multiplexed kinase inhibitor beads to study kinome adaptations in drug-resistant leukemia. Cooper MJ, Cox NJ, Zimmerman EI, Dewar BJ, Duncan JS, Whittle MC, Nguyen TA, Jones LS, Ghose Roy S, Smalley DM, Kuan PF, Richards KL, Christopherson RI, Jin J, Frye SV, Johnson GL, Baldwin AS, Graves LM. PLoS One. 2013 Jun 24;8(6):e66755. doi: 10.1371/journal.pone.0066755. Print 2013. PubMed |
| The RNA-binding protein fused in sarcoma (FUS) functions downstream of poly(ADP-ribose) polymerase (PARP) in response to DNA damage. Mastrocola AS, Kim SH, Trinh AT, Rodenkirch LA, Tibbetts RS. J Biol Chem. 2013 Aug 23;288(34):24731-41. doi: 10.1074/jbc.M113.497974. Epub 2013 Jul 5. PubMed |
| The DNA damage checkpoint precedes activation of ARF in response to escalating oncogenic stress during tumorigenesis. Evangelou K, Bartkova J, Kotsinas A, Pateras IS, Liontos M, Velimezi G, Kosar M, Liloglou T, Trougakos IP, Dyrskjot L, Andersen CL, Papaioannou M, Drosos Y, Papafotiou G, Hodny Z, Sosa-Pineda B, Wu XR, Klinakis A, Orntoft T, Lukas J, Bartek J, Gorgoulis VG. Cell Death Differ. 2013 Nov;20(11):1485-97. doi: 10.1038/cdd.2013.76. Epub 2013 Jul 12. PubMed |
| The Pitx2:miR-200c/141:noggin pathway regulates Bmp signaling and ameloblast differentiation. Cao H, Jheon A, Li X, Sun Z, Wang J, Florez S, Zhang Z, McManus MT, Klein OD, Amendt BA. Development. 2013 Aug;140(16):3348-59. doi: 10.1242/dev.089193. Epub 2013 Jul 17. PubMed |
| Fine time course expression analysis identifies cascades of activation and repression and maps a putative regulator of mammalian sex determination. Munger SC, Natarajan A, Looger LL, Ohler U, Capel B. PLoS Genet. 2013;9(7):e1003630. doi: 10.1371/journal.pgen.1003630. Epub 2013 Jul 11. PubMed |
| Transcriptional repression of Bim by a novel YY1-RelA complex is essential for the survival and growth of Multiple Myeloma. Potluri V, Noothi SK, Vallabhapurapu SD, Yoon SO, Driscoll JJ, Lawrie CH, Vallabhapurapu S. PLoS One. 2013 Jul 10;8(7):e66121. doi: 10.1371/journal.pone.0066121. Print 2013. PubMed |
| Neuropathic and inflammatory pain are modulated by tuberoinfundibular peptide of 39 residues. Dimitrov EL, Kuo J, Kohno K, Usdin TB. Proc Natl Acad Sci U S A. 2013 Aug 6;110(32):13156-61. doi: 10.1073/pnas.1306342110. Epub 2013 Jul 22. PubMed |
| GRP78-targeting subtilase cytotoxin sensitizes cancer cells to photodynamic therapy. Firczuk M, Gabrysiak M, Barankiewicz J, Domagala A, Nowis D, Kujawa M, Jankowska-Steifer E, Wachowska M, Glodkowska-Mrowka E, Korsak B, Winiarska M, Golab J. Cell Death Dis. 2013 Jul 25;4:e741. doi: 10.1038/cddis.2013.265. PubMed |
| Impairment of endothelial-myocardial interaction increases the susceptibility of cardiomyocytes to ischemia/reperfusion injury. Leucker TM, Ge ZD, Procknow J, Liu Y, Shi Y, Bienengraeber M, Warltier DC, Kersten JR. PLoS One. 2013 Jul 22;8(7):e70088. doi: 10.1371/journal.pone.0070088. Print 2013. PubMed |
| pRb controls estrogen receptor alpha protein stability and activity. Caligiuri I, Toffoli G, Giordano A, Rizzolio F. Oncotarget. 2013 Jun;4(6):875-83. PubMed |
| Pid1 induces insulin resistance in both human and mouse skeletal muscle during obesity. Bonala S, McFarlane C, Ang J, Lim R, Lee M, Chua H, Lokireddy S, Sreekanth P, Leow MK, Meng KC, Shyong TE, Lee YS, Gluckman PD, Sharma M, Kambadur R. Mol Endocrinol. 2013 Sep;27(9):1518-35. doi: 10.1210/me.2013-1048. Epub 2013 Aug 8. PubMed |
| Length-dependent CTG.CAG triplet-repeat expansion in myotonic dystrophy patient-derived induced pluripotent stem cells. Du J, Campau E, Soragni E, Jespersen C, Gottesfeld JM. Hum Mol Genet. 2013 Dec 20;22(25):5276-87. doi: 10.1093/hmg/ddt386. Epub 2013 Aug 9. PubMed |
| Rab18 binds to hepatitis C virus NS5A and promotes interaction between sites of viral replication and lipid droplets. Salloum S, Wang H, Ferguson C, Parton RG, Tai AW. PLoS Pathog. 2013;9(8):e1003513. doi: 10.1371/journal.ppat.1003513. Epub 2013 Aug 1. PubMed |
| Knockdown of specific host factors protects against influenza virus-induced cell death. Tran AT, Rahim MN, Ranadheera C, Kroeker A, Cortens JP, Opanubi KJ, Wilkins JA, Coombs KM. Cell Death Dis. 2013 Aug 15;4:e769. doi: 10.1038/cddis.2013.296. PubMed |
| The zinc finger transcription factor ZXDC activates CCL2 gene expression by opposing BCL6-mediated repression. Ramsey JE, Fontes JD. Mol Immunol. 2013 Dec;56(4):768-80. doi: 10.1016/j.molimm.2013.07.001. Epub 2013 Aug 14. PubMed |
| Mesenchymal stem cell survival in the infarcted heart is enhanced by lentivirus vector-mediated heat shock protein 27 expression. McGinley LM, McMahon J, Stocca A, Duffy A, Flynn A, O'Toole D, O'Brien T. Hum Gene Ther. 2013 Oct;24(10):840-51. doi: 10.1089/hum.2011.009. PubMed |
| Noninvasive visualization of tumor growth in a human colorectal liver metastases xenograft model using bioluminescence in vivo imaging. Thalheimer A, Korb D, Bonicke L, Wiegering A, Muhling B, Schneider M, Koch S, Riedel SS, Germer CT, Beilhack A, Brandlein S, Otto C. J Surg Res. 2013 Nov;185(1):143-51. doi: 10.1016/j.jss.2013.03.024. Epub 2013 Mar 30. PubMed |
| FMRP regulates actin filament organization via the armadillo protein p0071. Nolze A, Schneider J, Keil R, Lederer M, Huttelmaier S, Kessels MM, Qualmann B, Hatzfeld M. RNA. 2013 Nov;19(11):1483-96. doi: 10.1261/rna.037945.112. Epub 2013 Sep 23. PubMed |
| Secreted Frizzled-related protein potentiation versus inhibition of Wnt3a/beta-catenin signaling. Xavier CP, Melikova M, Chuman Y, Uren A, Baljinnyam B, Rubin JS. Cell Signal. 2014 Jan;26(1):94-101. doi: 10.1016/j.cellsig.2013.09.016. Epub 2013 Sep 28. PubMed |
| Thalamic neuropeptide mediating the effects of nursing on lactation and maternal motivation. Cservenak M, Szabo ER, Bodnar I, Leko A, Palkovits M, Nagy GM, Usdin TB, Dobolyi A. Psychoneuroendocrinology. 2013 Dec;38(12):3070-84. doi: 10.1016/j.psyneuen.2013.09.004. Epub 2013 Sep 14. PubMed |
| Determination of the transforming activities of adenovirus oncogenes. Speiseder T, Nevels M, Dobner T. Methods Mol Biol. 2014;1089:105-15. doi: 10.1007/978-1-62703-679-5_8. PubMed |
| Role of JunB in adenosine A2B receptor-mediated vascular endothelial growth factor production. Ryzhov S, Biktasova A, Goldstein AE, Zhang Q, Biaggioni I, Dikov MM, Feoktistov I. Mol Pharmacol. 2014 Jan;85(1):62-73. doi: 10.1124/mol.113.088567. Epub 2013 Oct 17. PubMed |
| Doxycycline-regulated GDNF expression promotes axonal regeneration and functional recovery in transected peripheral nerve. Shakhbazau A, Mohanty C, Shcharbin D, Bryszewska M, Caminade AM, Majoral JP, Alant J, Midha R. J Control Release. 2013 Dec 28;172(3):841-51. doi: 10.1016/j.jconrel.2013.10.004. Epub 2013 Oct 17. PubMed |
| Depletion of a putatively druggable class of phosphatidylinositol kinases inhibits growth of p53-null tumors. Emerling BM, Hurov JB, Poulogiannis G, Tsukazawa KS, Choo-Wing R, Wulf GM, Bell EL, Shim HS, Lamia KA, Rameh LE, Bellinger G, Sasaki AT, Asara JM, Yuan X, Bullock A, Denicola GM, Song J, Brown V, Signoretti S, Cantley LC. Cell. 2013 Nov 7;155(4):844-57. doi: 10.1016/j.cell.2013.09.057. PubMed |
Parallel measurement of dynamic changes in translation rates in single cells.
Han K, Jaimovich A, Dey G, Ruggero D, Meyuhas O, Sonenberg N, Meyer T.
Nat Methods. 2014 Jan;11(1):86-93. doi: 10.1038/nmeth.2729. Epub 2013 Nov 10.
PubMed
Associated Plasmids |
| Establishing isogenic inducible cell lines using founder reporter lines and recombinase-mediated cassette exchange. Guan B, Magomi T, Wang TL, Shih IeM. Biotechniques. 2013 Nov;55(5):233-42. doi: 10.2144/000114098. PubMed |
| In vitro expansion and genetic modification of gastrointestinal stem cells in spheroid culture. Miyoshi H, Stappenbeck TS. Nat Protoc. 2013 Dec;8(12):2471-82. doi: 10.1038/nprot.2013.153. Epub 2013 Nov 14. PubMed |
| Adherens junction formation inhibits lentivirus entry and gene transfer. Padmashali R, You H, Karnik N, Lei P, Andreadis ST. PLoS One. 2013 Nov 13;8(11):e79265. doi: 10.1371/journal.pone.0079265. eCollection 2013. PubMed |
| Increased expression of S100A6 promotes cell proliferation and migration in human hepatocellular carcinoma. Li Z, Tang M, Ling B, Liu S, Zheng Y, Nie C, Yuan Z, Zhou L, Guo G, Tong A, Wei Y. J Mol Med (Berl). 2014 Mar;92(3):291-303. doi: 10.1007/s00109-013-1104-3. Epub 2013 Nov 27. PubMed |
| Human keratinocyte cultures in the investigation of early steps of human papillomavirus infection. Griffin LM, Cicchini L, Xu T, Pyeon D. Methods Mol Biol. 2014;1195:219-38. doi: 10.1007/7651_2013_49. PubMed |
| A tumor suppressor function for the lipid phosphatase INPP4B in melanocytic neoplasms. Perez-Lorenzo R, Gill KZ, Shen CH, Zhao FX, Zheng B, Schulze HJ, Silvers DN, Brunner G, Horst BA. J Invest Dermatol. 2014 May;134(5):1359-68. doi: 10.1038/jid.2013.511. Epub 2013 Nov 28. PubMed |
| Reduced expression of the chromatin remodeling gene ARID1A enhances gastric cancer cell migration and invasion via downregulation of E-cadherin transcription. Yan HB, Wang XF, Zhang Q, Tang ZQ, Jiang YH, Fan HZ, Sun YH, Yang PY, Liu F. Carcinogenesis. 2014 Apr;35(4):867-76. doi: 10.1093/carcin/bgt398. Epub 2013 Nov 30. PubMed |
| The small GTPase Arf6 is essential for the Tram/Trif pathway in TLR4 signaling. Van Acker T, Eyckerman S, Vande Walle L, Gerlo S, Goethals M, Lamkanfi M, Bovijn C, Tavernier J, Peelman F. J Biol Chem. 2014 Jan 17;289(3):1364-76. doi: 10.1074/jbc.M113.499194. Epub 2013 Dec 2. PubMed |
| A potassium leak channel silences hyperactive neurons and ameliorates status epilepticus. Dey D, Eckle VS, Vitko I, Sullivan KA, Lasiecka ZM, Winckler B, Stornetta RL, Williamson JM, Kapur J, Perez-Reyes E. Epilepsia. 2014 Feb;55(2):203-13. doi: 10.1111/epi.12472. Epub 2013 Dec 2. PubMed |
| Visualizing of signaling proteins on endosomes utilizing knockdown and reconstitution approach. Jeoung M, Galperin E. Methods Enzymol. 2014;534:47-63. doi: 10.1016/B978-0-12-397926-1.00003-2. PubMed |
| Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging. Gomes AP, Price NL, Ling AJ, Moslehi JJ, Montgomery MK, Rajman L, White JP, Teodoro JS, Wrann CD, Hubbard BP, Mercken EM, Palmeira CM, de Cabo R, Rolo AP, Turner N, Bell EL, Sinclair DA. Cell. 2013 Dec 19;155(7):1624-38. doi: 10.1016/j.cell.2013.11.037. PubMed |
| Quantitation of DNA double-strand break resection intermediates in human cells. Zhou Y, Caron P, Legube G, Paull TT. Nucleic Acids Res. 2014 Feb;42(3):e19. doi: 10.1093/nar/gkt1309. Epub 2013 Dec 19. PubMed |
| Pore-exposed tyrosine residues of P-glycoprotein are important hydrogen-bonding partners for drugs. Donmez Cakil Y, Khunweeraphong N, Parveen Z, Schmid D, Artaker M, Ecker GF, Sitte HH, Pusch O, Stockner T, Chiba P. Mol Pharmacol. 2014 Mar;85(3):420-8. doi: 10.1124/mol.113.088526. Epub 2013 Dec 23. PubMed |
| mTOR target NDRG1 confers MGMT-dependent resistance to alkylating chemotherapy. Weiler M, Blaes J, Pusch S, Sahm F, Czabanka M, Luger S, Bunse L, Solecki G, Eichwald V, Jugold M, Hodecker S, Osswald M, Meisner C, Hielscher T, Rubmann P, Pfenning PN, Ronellenfitsch M, Kempf T, Schnolzer M, Abdollahi A, Lang F, Bendszus M, von Deimling A, Winkler F, Weller M, Vajkoczy P, Platten M, Wick W. Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):409-14. doi: 10.1073/pnas.1314469111. Epub 2013 Dec 23. PubMed |
| A human torque teno virus encodes a microRNA that inhibits interferon signaling. Kincaid RP, Burke JM, Cox JC, de Villiers EM, Sullivan CS. PLoS Pathog. 2013;9(12):e1003818. doi: 10.1371/journal.ppat.1003818. Epub 2013 Dec 19. PubMed |
| BET bromodomain inhibition triggers apoptosis of NF1-associated malignant peripheral nerve sheath tumors through Bim induction. Patel AJ, Liao CP, Chen Z, Liu C, Wang Y, Le LQ. Cell Rep. 2014 Jan 16;6(1):81-92. doi: 10.1016/j.celrep.2013.12.001. Epub 2013 Dec 27. PubMed |
| The FOS transcription factor family differentially controls trophoblast migration and invasion. Renaud SJ, Kubota K, Rumi MA, Soares MJ. J Biol Chem. 2014 Feb 21;289(8):5025-39. doi: 10.1074/jbc.M113.523746. Epub 2013 Dec 30. PubMed |
Tight control of hypoxia-inducible factor-alpha transient dynamics is essential for cell survival in hypoxia.
Bagnall J, Leedale J, Taylor SE, Spiller DG, White MR, Sharkey KJ, Bearon RN, See V.
J Biol Chem. 2014 Feb 28;289(9):5549-64. doi: 10.1074/jbc.M113.500405. Epub 2014 Jan 6.
PubMed
Associated Plasmids |
| Inhibition of stearoyl-coA desaturase selectively eliminates tumorigenic Nanog-positive cells: improving the safety of iPS cell transplantation to myocardium. Zhang L, Pan Y, Qin G, Chen L, Chatterjee TK, Weintraub NL, Tang Y. Cell Cycle. 2014;13(5):762-71. doi: 10.4161/cc.27677. Epub 2014 Jan 6. PubMed |
| microRNAs miR-27a and miR-27b directly regulate liver dihydropyrimidine dehydrogenase expression through two conserved binding sites. Offer SM, Butterfield GL, Jerde CR, Fossum CC, Wegner NJ, Diasio RB. Mol Cancer Ther. 2014 Mar;13(3):742-51. doi: 10.1158/1535-7163.MCT-13-0878. Epub 2014 Jan 8. PubMed |
| Dystrophin-deficient cardiomyocytes derived from human urine: new biologic reagents for drug discovery. Guan X, Mack DL, Moreno CM, Strande JL, Mathieu J, Shi Y, Markert CD, Wang Z, Liu G, Lawlor MW, Moorefield EC, Jones TN, Fugate JA, Furth ME, Murry CE, Ruohola-Baker H, Zhang Y, Santana LF, Childers MK. Stem Cell Res. 2014 Mar;12(2):467-80. doi: 10.1016/j.scr.2013.12.004. Epub 2013 Dec 23. PubMed |
| CCN2 suppresses catabolic effects of interleukin-1beta through alpha5beta1 and alphaVbeta3 integrins in nucleus pulposus cells: implications in intervertebral disc degeneration. Tran CM, Schoepflin ZR, Markova DZ, Kepler CK, Anderson DG, Shapiro IM, Risbud MV. J Biol Chem. 2014 Mar 14;289(11):7374-87. doi: 10.1074/jbc.M113.526111. Epub 2014 Jan 24. PubMed |
| All-trans-retinoic acid antagonizes the Hedgehog pathway by inducing patched. Busch AM, Galimberti F, Nehls KE, Roengvoraphoj M, Sekula D, Li B, Guo Y, Direnzo J, Fiering SN, Spinella MJ, Robbins DJ, Memoli VA, Freemantle SJ, Dmitrovsky E. Cancer Biol Ther. 2014 Apr;15(4):463-72. doi: 10.4161/cbt.27821. Epub 2014 Feb 4. PubMed |
| Oxysterol-binding protein is a phosphatidylinositol 4-kinase effector required for HCV replication membrane integrity and cholesterol trafficking. Wang H, Perry JW, Lauring AS, Neddermann P, De Francesco R, Tai AW. Gastroenterology. 2014 May;146(5):1373-85.e1-11. doi: 10.1053/j.gastro.2014.02.002. Epub 2014 Feb 8. PubMed |
| Importance of CD44 in the proliferation and mineralization of periodontal ligament cells. Yeh Y, Yang Y, Yuan K. J Periodontal Res. 2014 Dec;49(6):827-35. doi: 10.1111/jre.12170. Epub 2014 Feb 12. PubMed |
The PYRIN domain-only protein POP3 inhibits ALR inflammasomes and regulates responses to infection with DNA viruses.
Khare S, Ratsimandresy RA, de Almeida L, Cuda CM, Rellick SL, Misharin AV, Wallin MC, Gangopadhyay A, Forte E, Gottwein E, Perlman H, Reed JC, Greaves DR, Dorfleutner A, Stehlik C.
Nat Immunol. 2014 Apr;15(4):343-53. doi: 10.1038/ni.2829. Epub 2014 Feb 16.
PubMed
Associated Plasmids |
| deltaNp63 has a role in maintaining epithelial integrity in airway epithelium. Arason AJ, Jonsdottir HR, Halldorsson S, Benediktsdottir BE, Bergthorsson JT, Ingthorsson S, Baldursson O, Sinha S, Gudjonsson T, Magnusson MK. PLoS One. 2014 Feb 12;9(2):e88683. doi: 10.1371/journal.pone.0088683. eCollection 2014. PubMed |
| Design and analysis of site-specific single-strand nicking endonucleases for gene correction. Metzger MJ, Certo MT. Methods Mol Biol. 2014;1114:237-44. doi: 10.1007/978-1-62703-761-7_15. PubMed |
| Generation of transgene-free mouse induced pluripotent stem cells using an excisable lentiviral system. Varga E, Nemes C, Davis RP, Ujhelly O, Klincumhom N, Polgar Z, Muenthaisong S, Pirity MK, Dinnyes A. Exp Cell Res. 2014 Apr 1;322(2):335-44. doi: 10.1016/j.yexcr.2014.02.006. Epub 2014 Feb 18. PubMed |
| Inhibition of mTORC1 induces loss of E-cadherin through AKT/GSK-3beta signaling-mediated upregulation of E-cadherin repressor complexes in non-small cell lung cancer cells. Kim EY, Kim A, Kim SK, Kim HJ, Chang J, Ahn CM, Chang YS. Respir Res. 2014 Feb 26;15:26. doi: 10.1186/1465-9921-15-26. PubMed |
| Adipose tissue-derived stem cell secreted IGF-1 protects myoblasts from the negative effect of myostatin. Gehmert S, Wenzel C, Loibl M, Brockhoff G, Huber M, Krutsch W, Nerlich M, Gosau M, Klein S, Schreml S, Prantl L, Gehmert S. Biomed Res Int. 2014;2014:129048. doi: 10.1155/2014/129048. Epub 2014 Jan 23. PubMed |
| The Vac14-interaction network is linked to regulators of the endolysosomal and autophagic pathway. Schulze U, Vollenbroker B, Braun DA, Van Le T, Granado D, Kremerskothen J, Franzel B, Klosowski R, Barth J, Fufezan C, Wolters DA, Pavenstadt H, Weide T. Mol Cell Proteomics. 2014 Jun;13(6):1397-411. doi: 10.1074/mcp.M113.034108. Epub 2014 Feb 27. PubMed |
| RIP1 maintains DNA integrity and cell proliferation by regulating PGC-1alpha-mediated mitochondrial oxidative phosphorylation and glycolysis. Chen W, Wang Q, Bai L, Chen W, Wang X, Tellez CS, Leng S, Padilla MT, Nyunoya T, Belinsky SA, Lin Y. Cell Death Differ. 2014 Jul;21(7):1061-70. doi: 10.1038/cdd.2014.25. Epub 2014 Feb 28. PubMed |
| Inhibition of TGFbeta signaling increases direct conversion of fibroblasts to induced cardiomyocytes. Ifkovits JL, Addis RC, Epstein JA, Gearhart JD. PLoS One. 2014 Feb 26;9(2):e89678. doi: 10.1371/journal.pone.0089678. eCollection 2014. PubMed |
| Specific calcineurin targeting in macrophages confers resistance to inflammation via MKP-1 and p38. Escolano A, Martinez-Martinez S, Alfranca A, Urso K, Izquierdo HM, Delgado M, Martin F, Sabio G, Sancho D, Gomez-del Arco P, Redondo JM. EMBO J. 2014 May 16;33(10):1117-33. doi: 10.1002/embj.201386369. Epub 2014 Mar 3. PubMed |
| Cocaine disrupts histamine H3 receptor modulation of dopamine D1 receptor signaling: sigma1-D1-H3 receptor complexes as key targets for reducing cocaine's effects. Moreno E, Moreno-Delgado D, Navarro G, Hoffmann HM, Fuentes S, Rosell-Vilar S, Gasperini P, Rodriguez-Ruiz M, Medrano M, Mallol J, Cortes A, Casado V, Lluis C, Ferre S, Ortiz J, Canela E, McCormick PJ. J Neurosci. 2014 Mar 5;34(10):3545-58. doi: 10.1523/JNEUROSCI.4147-13.2014. PubMed |
| Production, purification and titration of a lentivirus-based vector for gene delivery purposes. Nasri M, Karimi A, Allahbakhshian Farsani M. Cytotechnology. 2014 Dec;66(6):1031-8. doi: 10.1007/s10616-013-9652-5. Epub 2014 Mar 6. PubMed |
| Inter-cellular exchange of cellular components via VE-cadherin-dependent trans-endocytosis. Sakurai T, Woolls MJ, Jin SW, Murakami M, Simons M. PLoS One. 2014 Mar 6;9(6):e90736. doi: 10.1371/journal.pone.0090736. eCollection 2014. PubMed |
| hCLE/C14orf166 associates with DDX1-HSPC117-FAM98B in a novel transcription-dependent shuttling RNA-transporting complex. Perez-Gonzalez A, Pazo A, Navajas R, Ciordia S, Rodriguez-Frandsen A, Nieto A. PLoS One. 2014 Mar 7;9(3):e90957. doi: 10.1371/journal.pone.0090957. eCollection 2014. PubMed |
| SAA1 polymorphisms are associated with variation in antiangiogenic and tumor-suppressive activities in nasopharyngeal carcinoma. Lung HL, Man OY, Yeung MC, Ko JM, Cheung AK, Law EW, Yu Z, Shuen WH, Tung E, Chan SH, Bangarusamy DK, Cheng Y, Yang X, Kan R, Phoon Y, Chan KC, Chua D, Kwong DL, Lee AW, Ji MF, Lung ML. Oncogene. 2015 Feb 12;34(7):878-89. doi: 10.1038/onc.2014.12. Epub 2014 Mar 10. PubMed |
| GP73 is upregulated by hepatitis C virus (HCV) infection and enhances HCV secretion. Hu L, Yao W, Wang F, Rong X, Peng T. PLoS One. 2014 Mar 7;9(3):e90553. doi: 10.1371/journal.pone.0090553. eCollection 2014. PubMed |
| The Hippo transducer TAZ interacts with the SWI/SNF complex to regulate breast epithelial lineage commitment. Skibinski A, Breindel JL, Prat A, Galvan P, Smith E, Rolfs A, Gupta PB, Labaer J, Kuperwasser C. Cell Rep. 2014 Mar 27;6(6):1059-72. doi: 10.1016/j.celrep.2014.02.038. Epub 2014 Mar 6. PubMed |
| Sphingosine Phosphate Lyase Regulates Murine Embryonic Stem Cell Proliferation and Pluripotency through an S1P/STAT3 Signaling Pathway. Smith GS, Kumar A, Saba JD. Biomolecules. 2013 Jun 24;3(3):351-368. PubMed |
| EMP1, a novel poor prognostic factor in pediatric leukemia regulates prednisolone resistance, cell proliferation, migration and adhesion. Aries IM, Jerchel IS, van den Dungen RE, van den Berk LC, Boer JM, Horstmann MA, Escherich G, Pieters R, den Boer ML. Leukemia. 2014 Sep;28(9):1828-37. doi: 10.1038/leu.2014.80. Epub 2014 Feb 20. PubMed |
| A protective antigen mutation increases the pH threshold of anthrax toxin receptor 2-mediated pore formation. Dennis MK, Mogridge J. Biochemistry. 2014 Apr 8;53(13):2166-71. doi: 10.1021/bi5000756. Epub 2014 Mar 25. PubMed |
| MiR-92a regulates viability and angiogenesis of endothelial cells under oxidative stress. Zhang L, Zhou M, Qin G, Weintraub NL, Tang Y. Biochem Biophys Res Commun. 2014 Apr 18;446(4):952-8. doi: 10.1016/j.bbrc.2014.03.035. Epub 2014 Mar 17. PubMed |
RPTPalpha controls epithelial adherens junctions, linking E-cadherin engagement to c-Src-mediated phosphorylation of cortactin.
Truffi M, Dubreuil V, Liang X, Vacaresse N, Nigon F, Han SP, Yap AS, Gomez GA, Sap J.
J Cell Sci. 2014 Jun 1;127(Pt 11):2420-32. doi: 10.1242/jcs.134379. Epub 2014 Mar 20.
PubMed
Associated Plasmids |
| Expressed glycosylphosphatidylinositol-anchored horseradish peroxidase identifies co-clustering molecules in individual lipid raft domains. Miyagawa-Yamaguchi A, Kotani N, Honke K. PLoS One. 2014 Mar 26;9(3):e93054. doi: 10.1371/journal.pone.0093054. eCollection 2014. PubMed |
| Evolutionary and molecular facts link the WWC protein family to Hippo signaling. Wennmann DO, Schmitz J, Wehr MC, Krahn MP, Koschmal N, Gromnitza S, Schulze U, Weide T, Chekuri A, Skryabin BV, Gerke V, Pavenstadt H, Duning K, Kremerskothen J. Mol Biol Evol. 2014 Jul;31(7):1710-23. doi: 10.1093/molbev/msu115. Epub 2014 Mar 27. PubMed |
| Myostatin knockdown and its effect on myogenic gene expression program in stably transfected goat myoblasts. Patel AK, Tripathi AK, Patel UA, Shah RK, Joshi CG. In Vitro Cell Dev Biol Anim. 2014 Aug;50(7):587-96. doi: 10.1007/s11626-014-9743-4. Epub 2014 Mar 28. PubMed |
| Activation of neural cell fate programs toward direct conversion of adult human fibroblasts into tri-potent neural progenitors using OCT-4. Mitchell RR, Szabo E, Benoit YD, Case DT, Mechael R, Alamilla J, Lee JH, Fiebig-Comyn A, Gillespie DC, Bhatia M. Stem Cells Dev. 2014 Aug 15;23(16):1937-46. doi: 10.1089/scd.2014.0023. Epub 2014 May 13. PubMed |
| Generation and characterization of induced pluripotent stem cells from Aid-deficient mice. Shimamoto R, Amano N, Ichisaka T, Watanabe A, Yamanaka S, Okita K. PLoS One. 2014 Apr 9;9(4):e94735. doi: 10.1371/journal.pone.0094735. eCollection 2014. PubMed |
| CDK2-dependent phosphorylation of Suv39H1 is involved in control of heterochromatin replication during cell cycle progression. Park SH, Yu SE, Chai YG, Jang YK. Nucleic Acids Res. 2014 Jun;42(10):6196-207. doi: 10.1093/nar/gku263. Epub 2014 Apr 11. PubMed |
| Evaluation of apoptosis induction by concomitant inhibition of MEK, mTOR, and Bcl-2 in human acute myelogenous leukemia cells. Zhang W, Ruvolo VR, Gao C, Zhou L, Bornmann W, Tsao T, Schober WD, Smith P, Guichard S, Konopleva M, Andreeff M. Mol Cancer Ther. 2014 Jul;13(7):1848-59. doi: 10.1158/1535-7163.MCT-13-0576. Epub 2014 Apr 16. PubMed |
| Pancreatic beta-cell failure mediated by mTORC1 hyperactivity and autophagic impairment. Bartolome A, Kimura-Koyanagi M, Asahara S, Guillen C, Inoue H, Teruyama K, Shimizu S, Kanno A, Garcia-Aguilar A, Koike M, Uchiyama Y, Benito M, Noda T, Kido Y. Diabetes. 2014 Sep;63(9):2996-3008. doi: 10.2337/db13-0970. Epub 2014 Apr 16. PubMed |
| Transdifferentiation of mouse fibroblasts and hepatocytes to functional neurons. Marro S, Yang N. Methods Mol Biol. 2014;1150:237-46. doi: 10.1007/978-1-4939-0512-6_16. PubMed |
| "Triplet" polycistronic vectors encoding Gata4, Mef2c, and Tbx5 enhances postinfarct ventricular functional improvement compared with singlet vectors. Mathison M, Singh VP, Gersch RP, Ramirez MO, Cooney A, Kaminsky SM, Chiuchiolo MJ, Nasser A, Yang J, Crystal RG, Rosengart TK. J Thorac Cardiovasc Surg. 2014 Oct;148(4):1656-1664.e2. doi: 10.1016/j.jtcvs.2014.03.033. Epub 2014 Mar 27. PubMed |
| Increased genomic integrity of an improved protein-based mouse induced pluripotent stem cell method compared with current viral-induced strategies. Park H, Kim D, Kim CH, Mills RE, Chang MY, Iskow RC, Ko S, Moon JI, Choi HW, Man Yoo PS, Do JT, Han MJ, Lee EG, Jung JK, Zhang C, Lanza R, Kim KS. Stem Cells Transl Med. 2014 May;3(5):599-609. doi: 10.5966/sctm.2013-0149. Epub 2014 Apr 24. PubMed |
| Tissue-engineered cartilage with inducible and tunable immunomodulatory properties. Glass KA, Link JM, Brunger JM, Moutos FT, Gersbach CA, Guilak F. Biomaterials. 2014 Jul;35(22):5921-31. doi: 10.1016/j.biomaterials.2014.03.073. Epub 2014 Apr 22. PubMed |
| Murine norovirus: propagation, quantification, and genetic manipulation. Hwang S, Alhatlani B, Arias A, Caddy SL, Christodoulou C, Cunha JB, Emmott E, Gonzalez-Hernandez M, Kolawole A, Lu J, Rippinger C, Sorgeloos F, Thorne L, Vashist S, Goodfellow I, Wobus CE. Curr Protoc Microbiol. 2014 May 1;33:15K.2.1-61. doi: 10.1002/9780471729259.mc15k02s33. PubMed |
| Impact of an altered PROX1 expression on clinicopathology, prognosis and progression in renal cell carcinoma. Lv T, Liu Y, Zhang J, Xu L, Zhu Y, Yin H, An H, Lin Z, Xie Y, Chen L. PLoS One. 2014 May 5;9(5):e95996. doi: 10.1371/journal.pone.0095996. eCollection 2014. PubMed |
| Polymerase I and transcript release factor (PTRF) regulates adipocyte differentiation and determines adipose tissue expandability. Perez-Diaz S, Johnson LA, DeKroon RM, Moreno-Navarrete JM, Alzate O, Fernandez-Real JM, Maeda N, Arbones-Mainar JM. FASEB J. 2014 Aug;28(8):3769-79. doi: 10.1096/fj.14-251165. Epub 2014 May 8. PubMed |
| Long intergenic non-coding RNA HOTAIRM1 regulates cell cycle progression during myeloid maturation in NB4 human promyelocytic leukemia cells. Zhang X, Weissman SM, Newburger PE. RNA Biol. 2014;11(6):777-87. Epub 2014 Apr 24. PubMed |
| SIRT2 induces the checkpoint kinase BubR1 to increase lifespan. North BJ, Rosenberg MA, Jeganathan KB, Hafner AV, Michan S, Dai J, Baker DJ, Cen Y, Wu LE, Sauve AA, van Deursen JM, Rosenzweig A, Sinclair DA. EMBO J. 2014 Jul 1;33(13):1438-53. doi: 10.15252/embj.201386907. Epub 2014 May 12. PubMed |
| Quantitative proteomic analysis of host-virus interactions reveals a role for Golgi brefeldin A resistance factor 1 (GBF1) in dengue infection. Carpp LN, Rogers RS, Moritz RL, Aitchison JD. Mol Cell Proteomics. 2014 Nov;13(11):2836-54. doi: 10.1074/mcp.M114.038984. Epub 2014 May 22. PubMed |
| MST4 promotes hepatocellular carcinoma epithelial-mesenchymal transition and metastasis via activation of the p-ERK pathway. Lin ZH, Wang L, Zhang JB, Liu Y, Li XQ, Guo L, Zhang B, Zhu WW, Ye QH. Int J Oncol. 2014 Aug;45(2):629-40. doi: 10.3892/ijo.2014.2455. Epub 2014 May 22. PubMed |
| FIH-1-Mint3 axis does not control HIF-1 transcriptional activity in nucleus pulposus cells. Hirose Y, Johnson ZI, Schoepflin ZR, Markova DZ, Chiba K, Toyama Y, Shapiro IM, Risbud MV. J Biol Chem. 2014 Jul 25;289(30):20594-605. PubMed |
| Nrf2, a regulator of the proteasome, controls self-renewal and pluripotency in human embryonic stem cells. Jang J, Wang Y, Kim HS, Lalli MA, Kosik KS. Stem Cells. 2014 Oct;32(10):2616-25. doi: 10.1002/stem.1764. PubMed |
| Autophagy promotes resistance to photodynamic therapy-induced apoptosis selectively in colorectal cancer stem-like cells. Wei MF, Chen MW, Chen KC, Lou PJ, Lin SY, Hung SC, Hsiao M, Yao CJ, Shieh MJ. Autophagy. 2014 Jul;10(7):1179-92. doi: 10.4161/auto.28679. Epub 2014 Apr 29. PubMed |
| Molecular neuroimaging of post-injury plasticity. Jouroukhin Y, Nonyane BA, Gilad AA, Pelled G. J Mol Neurosci. 2014 Dec;54(4):630-8. doi: 10.1007/s12031-014-0347-y. Epub 2014 Jun 10. PubMed |
| Sorting cells for basal and induced autophagic flux by quantitative ratiometric flow cytometry. Gump JM, Thorburn A. Autophagy. 2014 Jul;10(7):1327-34. doi: 10.4161/auto.29394. Epub 2014 Jun 5. PubMed |
| Inhibition of glutathione peroxidase mediates the collateral sensitivity of multidrug-resistant cells to tiopronin. Hall MD, Marshall TS, Kwit AD, Miller Jenkins LM, Dulcey AE, Madigan JP, Pluchino KM, Goldsborough AS, Brimacombe KR, Griffiths GL, Gottesman MM. J Biol Chem. 2014 Aug 1;289(31):21473-89. doi: 10.1074/jbc.M114.581702. Epub 2014 Jun 14. PubMed |
| 17beta-estradiol regulates giant vesicle formation via estrogen receptor-alpha in human breast cancer cells. Wright PK, Jones SB, Ardern N, Ward R, Clarke RB, Sotgia F, Lisanti MP, Landberg G, Lamb R. Oncotarget. 2014 May 30;5(10):3055-65. PubMed |
| The prolyl peptidases PRCP/PREP regulate IRS-1 stability critical for rapamycin-induced feedback activation of PI3K and AKT. Duan L, Ying G, Danzer B, Perez RE, Shariat-Madar Z, Levenson VV, Maki CG. J Biol Chem. 2014 Aug 1;289(31):21694-705. doi: 10.1074/jbc.M114.550038. Epub 2014 Jun 16. PubMed |
| IL-17 and GM-CSF expression are antagonistically regulated by human T helper cells. Noster R, Riedel R, Mashreghi MF, Radbruch H, Harms L, Haftmann C, Chang HD, Radbruch A, Zielinski CE. Sci Transl Med. 2014 Jun 18;6(241):241ra80. doi: 10.1126/scitranslmed.3008706. PubMed |
| Presynaptic clathrin levels are a limiting factor for synaptic transmission. Lopez-Murcia FJ, Royle SJ, Llobet A. J Neurosci. 2014 Jun 18;34(25):8618-29. doi: 10.1523/JNEUROSCI.5081-13.2014. PubMed |
Generation of mouse models of myeloid malignancy with combinatorial genetic lesions using CRISPR-Cas9 genome editing.
Heckl D, Kowalczyk MS, Yudovich D, Belizaire R, Puram RV, McConkey ME, Thielke A, Aster JC, Regev A, Ebert BL.
Nat Biotechnol. 2014 Jun 22. doi: 10.1038/nbt.2951.
PubMed
Associated Plasmids |
| Assessing the efficacy of nano- and micro-sized magnetic particles as contrast agents for MRI cell tracking. Taylor A, Herrmann A, Moss D, See V, Davies K, Williams SR, Murray P. PLoS One. 2014 Jun 24;9(6):e100259. doi: 10.1371/journal.pone.0100259. eCollection 2014. PubMed |
| Quantitative phosphoproteomics reveals novel phosphorylation events in insulin signaling regulated by protein phosphatase 1 regulatory subunit 12A. Zhang X, Ma D, Caruso M, Lewis M, Qi Y, Yi Z. J Proteomics. 2014 Sep 23;109:63-75. doi: 10.1016/j.jprot.2014.06.010. Epub 2014 Jun 25. PubMed |
| PKCzeta and PKMzeta are overexpressed in TCF3-rearranged paediatric acute lymphoblastic leukaemia and are associated with increased thiopurine sensitivity. Hartsink-Segers SA, Beaudoin JJ, Luijendijk MW, Exalto C, Pieters R, Den Boer ML. Leukemia. 2015 Feb;29(2):304-11. doi: 10.1038/leu.2014.210. Epub 2014 Jul 3. PubMed |
| ERbeta- and prostaglandin E2-regulated pathways integrate cell proliferation via Ras-like and estrogen-regulated growth inhibitor in endometriosis. Monsivais D, Dyson MT, Yin P, Coon JS, Navarro A, Feng G, Malpani SS, Ono M, Ercan CM, Wei JJ, Pavone ME, Su E, Bulun SE. Mol Endocrinol. 2014 Aug;28(8):1304-15. doi: 10.1210/me.2013-1421. Epub 2014 Jul 3. PubMed |
| Live cell imaging of primary rat neonatal cardiomyocytes following adenoviral and lentiviral transduction using confocal spinning disk microscopy. Sakurai T, Lanahan A, Woolls MJ, Li N, Tirziu D, Murakami M. J Vis Exp. 2014 Jun 24;(88):e51666. doi: 10.3791/51666. PubMed |
| Sirtuin1 (Sirt1) promotes cortical bone formation by preventing beta-catenin sequestration by FoxO transcription factors in osteoblast progenitors. Iyer S, Han L, Bartell SM, Kim HN, Gubrij I, de Cabo R, O'Brien CA, Manolagas SC, Almeida M. J Biol Chem. 2014 Aug 29;289(35):24069-78. doi: 10.1074/jbc.M114.561803. Epub 2014 Jul 7. PubMed |
| Par3-mInsc and Galphai3 cooperate to promote oriented epidermal cell divisions through LGN. Williams SE, Ratliff LA, Postiglione MP, Knoblich JA, Fuchs E. Nat Cell Biol. 2014 Aug;16(8):758-69. doi: 10.1038/ncb3001. Epub 2014 Jul 13. PubMed |
| CREB SUMOylation by the E3 ligase PIAS1 enhances spatial memory. Chen YC, Hsu WL, Ma YL, Tai DJ, Lee EH. J Neurosci. 2014 Jul 16;34(29):9574-89. doi: 10.1523/JNEUROSCI.4302-13.2014. PubMed |
| Differential requirements of arrestin-3 and clathrin for ligand-dependent and -independent internalization of human G protein-coupled receptor 40. Qian J, Wu C, Chen X, Li X, Ying G, Jin L, Ma Q, Li G, Shi Y, Zhang G, Zhou N. Cell Signal. 2014 Nov;26(11):2412-23. doi: 10.1016/j.cellsig.2014.07.019. Epub 2014 Jul 16. PubMed |
| Oncogenic role of Merlin/NF2 in glioblastoma. Guerrero PA, Yin W, Camacho L, Marchetti D. Oncogene. 2015 May 14;34(20):2621-30. doi: 10.1038/onc.2014.185. Epub 2014 Jul 21. PubMed |
| Lentiviral gene transduction of mouse and human hematopoietic stem cells. van Til NP, Wagemaker G. Methods Mol Biol. 2014;1185:311-9. doi: 10.1007/978-1-4939-1133-2_21. PubMed |
| Tumor necrosis factor-alpha- and interleukin-1beta-dependent matrix metalloproteinase-3 expression in nucleus pulposus cells requires cooperative signaling via syndecan 4 and mitogen-activated protein kinase-NF-kappaB axis: implications in inflammatory disc disease. Wang X, Wang H, Yang H, Li J, Cai Q, Shapiro IM, Risbud MV. Am J Pathol. 2014 Sep;184(9):2560-72. doi: 10.1016/j.ajpath.2014.06.006. Epub 2014 Jul 22. PubMed |
| A home-brew real-time PCR assay for reliable detection and quantification of mature miR-122. Naderi M, Abdul Tehrani H, Soleimani M, Shabani I, Hashemi SM. Appl Immunohistochem Mol Morphol. 2015 Sep;23(8):601-6. doi: 10.1097/PAI.0000000000000125. PubMed |
| Analysis of transcription factor network underlying 3T3-L1 adipocyte differentiation. Choi K, Ghaddar B, Moya C, Shi H, Sridharan GV, Lee K, Jayaraman A. PLoS One. 2014 Jul 30;9(7):e100177. doi: 10.1371/journal.pone.0100177. eCollection 2014. PubMed |
| SOX2 is a cancer-specific regulator of tumour initiating potential in cutaneous squamous cell carcinoma. Siegle JM, Basin A, Sastre-Perona A, Yonekubo Y, Brown J, Sennett R, Rendl M, Tsirigos A, Carucci JA, Schober M. Nat Commun. 2014 Jul 31;5:4511. doi: 10.1038/ncomms5511. PubMed |
| StUbEx: Stable tagged ubiquitin exchange system for the global investigation of cellular ubiquitination. Akimov V, Henningsen J, Hallenborg P, Rigbolt KT, Jensen SS, Nielsen MM, Kratchmarova I, Blagoev B. J Proteome Res. 2014 Sep 5;13(9):4192-204. doi: 10.1021/pr500549h. Epub 2014 Aug 15. PubMed |
| An essential role for the K+-dependent Na+/Ca2+-exchanger, NCKX4, in melanocortin-4-receptor-dependent satiety. Li XF, Lytton J. J Biol Chem. 2014 Sep 12;289(37):25445-59. doi: 10.1074/jbc.M114.564450. Epub 2014 Aug 5. PubMed |
| Porcine reproductive and respiratory syndrome virus counteracts the porcine intrinsic virus restriction factors-IFITM1 and Tetherin in MARC-145 cells. Wang X, Li C, Zhou L, Zhang N, Wang X, Ge X, Guo X, Yang H. Virus Res. 2014 Oct 13;191:92-100. doi: 10.1016/j.virusres.2014.07.025. Epub 2014 Aug 4. PubMed |
| An acetate switch regulates stress erythropoiesis. Xu M, Nagati JS, Xie J, Li J, Walters H, Moon YA, Gerard RD, Huang CL, Comerford SA, Hammer RE, Horton JD, Chen R, Garcia JA. Nat Med. 2014 Sep;20(9):1018-26. doi: 10.1038/nm.3587. Epub 2014 Aug 10. PubMed |
| Myeloid-specific disruption of tyrosine phosphatase Shp2 promotes alternative activation of macrophages and predisposes mice to pulmonary fibrosis. Tao B, Jin W, Xu J, Liang Z, Yao J, Zhang Y, Wang K, Cheng H, Zhang X, Ke Y. J Immunol. 2014 Sep 15;193(6):2801-11. doi: 10.4049/jimmunol.1303463. Epub 2014 Aug 15. PubMed |
| PGE2-induced colon cancer growth is mediated by mTORC1. Dufour M, Faes S, Dormond-Meuwly A, Demartines N, Dormond O. Biochem Biophys Res Commun. 2014 Sep 5;451(4):587-91. doi: 10.1016/j.bbrc.2014.08.032. Epub 2014 Aug 13. PubMed |
| Human somatic cell mutagenesis creates genetically tractable sarcomas. Molyneux SD, Waterhouse PD, Shelton D, Shao YW, Watling CM, Tang QL, Harris IS, Dickson BC, Tharmapalan P, Sandve GK, Zhang X, Bailey SD, Berman H, Wunder JS, Izsvak Z, Lupien M, Mak TW, Khokha R. Nat Genet. 2014 Sep;46(9):964-72. doi: 10.1038/ng.3065. Epub 2014 Aug 17. PubMed |
| Phosphorylation site dynamics of early T-cell receptor signaling. Chylek LA, Akimov V, Dengjel J, Rigbolt KT, Hu B, Hlavacek WS, Blagoev B. PLoS One. 2014 Aug 22;9(8):e104240. doi: 10.1371/journal.pone.0104240. eCollection 2014. PubMed |
| Label-free, live optical imaging of reprogrammed bipolar disorder patient-derived cells reveals a functional correlate of lithium responsiveness. Wang JL, Shamah SM, Sun AX, Waldman ID, Haggarty SJ, Perlis RH. Transl Psychiatry. 2014 Aug 26;4:e428. doi: 10.1038/tp.2014.72. PubMed |
| Pcgf6, a polycomb group protein, regulates mesodermal lineage differentiation in murine ESCs and functions in iPS reprogramming. Zdzieblo D, Li X, Lin Q, Zenke M, Illich DJ, Becker M, Muller AM. Stem Cells. 2014 Dec;32(12):3112-25. doi: 10.1002/stem.1826. PubMed |
| Spatial control of Cdc42 signalling by a GM130-RasGRF complex regulates polarity and tumorigenesis. Baschieri F, Confalonieri S, Bertalot G, Di Fiore PP, Dietmaier W, Leist M, Crespo P, Macara IG, Farhan H. Nat Commun. 2014 Sep 11;5:4839. doi: 10.1038/ncomms5839. PubMed |
| Lipid phosphate phosphatase-1 expression in cancer cells attenuates tumor growth and metastasis in mice. Tang X, Benesch MG, Dewald J, Zhao YY, Patwardhan N, Santos WL, Curtis JM, McMullen TP, Brindley DN. J Lipid Res. 2014 Nov;55(11):2389-400. doi: 10.1194/jlr.M053462. Epub 2014 Sep 10. PubMed |
| HBZ stimulates brain-derived neurotrophic factor/TrkB autocrine/paracrine signaling to promote survival of human T-cell leukemia virus type 1-Infected T cells. Polakowski N, Terol M, Hoang K, Nash I, Laverdure S, Gazon H, Belrose G, Mesnard JM, Cesaire R, Peloponese JM, Lemasson I. J Virol. 2014 Nov;88(22):13482-94. doi: 10.1128/JVI.02285-14. Epub 2014 Sep 10. PubMed |
| Interleukin-like epithelial-to-mesenchymal transition inducer activity is controlled by proteolytic processing and plasminogen-urokinase plasminogen activator receptor system-regulated secretion during breast cancer progression. Csiszar A, Kutay B, Wirth S, Schmidt U, Macho-Maschler S, Schreiber M, Alacakaptan M, Vogel GF, Aumayr K, Huber LA, Beug H. Breast Cancer Res. 2014 Sep 9;16(5):433. doi: 10.1186/s13058-014-0433-7. PubMed |
| CERS2 suppresses tumor cell invasion and is associated with decreased V-ATPase and MMP-2/MMP-9 activities in breast cancer. Fan SH, Wang YY, Lu J, Zheng YL, Wu DM, Zhang ZF, Shan Q, Hu B, Li MQ, Cheng W. J Cell Biochem. 2015 Apr;116(4):502-13. doi: 10.1002/jcb.24978. PubMed |
| A robust transfection reagent for the transfection of CHO and HEK293 cells and production of recombinant proteins and lentiviral particles - PTG1. Goncalves C, Gross F, Guegan P, Cheradame H, Midou P. Biotechnol J. 2014 Nov;9(11):1380-8. doi: 10.1002/biot.201400324. Epub 2014 Oct 15. PubMed |
DDX3 DEAD-box RNA helicase is a host factor that restricts hepatitis B virus replication at the transcriptional level.
Ko C, Lee S, Windisch MP, Ryu WS.
J Virol. 2014 Dec;88(23):13689-98. doi: 10.1128/JVI.02035-14. Epub 2014 Sep 17.
PubMed
Associated Plasmids |
| Study of galectins in tumor immunity: strategies and methods. Cerliani JP, Dalotto-Moreno T, Compagno D, Dergan-Dylon LS, Laderach DJ, Gentilini L, Croci DO, Mendez-Huergo SP, Toscano MA, Salatino M, Rabinovich GA. Methods Mol Biol. 2015;1207:249-68. doi: 10.1007/978-1-4939-1396-1_16. PubMed |
| Activation of the RIG-I pathway during influenza vaccination enhances the germinal center reaction, promotes T follicular helper cell induction, and provides a dose-sparing effect and protective immunity. Kulkarni RR, Rasheed MA, Bhaumik SK, Ranjan P, Cao W, Davis C, Marisetti K, Thomas S, Gangappa S, Sambhara S, Murali-Krishna K. J Virol. 2014 Dec;88(24):13990-4001. doi: 10.1128/JVI.02273-14. Epub 2014 Sep 24. PubMed |
| Bortezomib sensitizes primary meningioma cells to TRAIL-induced apoptosis by enhancing formation of the death-inducing signaling complex. Koschny R, Boehm C, Sprick MR, Haas TL, Holland H, Xu LX, Krupp W, Mueller WC, Bauer M, Koschny T, Keller M, Sinn P, Meixensberger J, Walczak H, Ganten TM. J Neuropathol Exp Neurol. 2014 Nov;73(11):1034-46. doi: 10.1097/NEN.0000000000000129. PubMed |
| ETS1 is a genome-wide effector of RAS/ERK signaling in epithelial cells. Plotnik JP, Budka JA, Ferris MW, Hollenhorst PC. Nucleic Acids Res. 2014 Oct 29;42(19):11928-40. doi: 10.1093/nar/gku929. Epub 2014 Oct 7. PubMed |
| A PTCH1 homolog transcriptionally activated by p53 suppresses Hedgehog signaling. Chung JH, Larsen AR, Chen E, Bunz F. J Biol Chem. 2014 Nov 21;289(47):33020-31. doi: 10.1074/jbc.M114.597203. Epub 2014 Oct 8. PubMed |
| The SNAI1 3'UTR functions as a sponge for multiple migration-/invasion-related microRNAs. Li J, Yu H, Xi M, Ma D, Lu X. Tumour Biol. 2015 Feb;36(2):1067-72. doi: 10.1007/s13277-014-2733-z. Epub 2014 Oct 19. PubMed |
| Vascular channels formed by subpopulations of PECAM1+ melanoma cells. Dunleavey JM, Xiao L, Thompson J, Kim MM, Shields JM, Shelton SE, Irvin DM, Brings VE, Ollila DW, Brekken RA, Dayton PA, Melero-Martin JM, Dudley AC. Nat Commun. 2014 Oct 22;5:5200. doi: 10.1038/ncomms6200. PubMed |
| Robo4 vaccines induce antibodies that retard tumor growth. Zhuang X, Ahmed F, Zhang Y, Ferguson HJ, Steele JC, Steven NM, Nagy Z, Heath VL, Toellner KM, Bicknell R. Angiogenesis. 2015 Jan;18(1):83-95. doi: 10.1007/s10456-014-9448-z. Epub 2014 Oct 28. PubMed |
| Functional analysis of prognostic gene expression network genes in metastatic breast cancer models. Geiger TR, Ha NH, Faraji F, Michael HT, Rodriguez L, Walker RC, Green JE, Simpson RM, Hunter KW. PLoS One. 2014 Nov 4;9(11):e111813. doi: 10.1371/journal.pone.0111813. eCollection 2014. PubMed |
| Regulation of RAB5C is important for the growth inhibitory effects of MiR-509 in human precursor-B acute lymphoblastic leukemia. Tan YS, Kim M, Kingsbury TJ, Civin CI, Cheng WC. PLoS One. 2014 Nov 4;9(11):e111777. doi: 10.1371/journal.pone.0111777. eCollection 2014. PubMed |
| The protein phosphatase 2A inhibitor LB100 sensitizes ovarian carcinoma cells to cisplatin-mediated cytotoxicity. Chang KE, Wei BR, Madigan JP, Hall MD, Simpson RM, Zhuang Z, Gottesman MM. Mol Cancer Ther. 2015 Jan;14(1):90-100. doi: 10.1158/1535-7163.MCT-14-0496. Epub 2014 Nov 5. PubMed |
| The Hippo pathway is controlled by Angiotensin II signaling and its reactivation induces apoptosis in podocytes. Wennmann DO, Vollenbroker B, Eckart AK, Bonse J, Erdmann F, Wolters DA, Schenk LK, Schulze U, Kremerskothen J, Weide T, Pavenstadt H. Cell Death Dis. 2014 Nov 13;5:e1519. doi: 10.1038/cddis.2014.476. PubMed |
| Stable suppression of myostatin gene expression in goat fetal fibroblast cells by lentiviral vector-mediated RNAi. Patel UA, Patel AK, Joshi CG. Biotechnol Prog. 2015 Mar;31(2):452-9. doi: 10.1002/btpr.2022. Epub 2014 Nov 24. PubMed |
| Inhibition of class I HDACs abrogates the dominant effect of MLL-AF4 by activation of wild-type MLL. Ahmad K, Katryniok C, Scholz B, Merkens J, Loscher D, Marschalek R, Steinhilber D. Oncogenesis. 2014 Nov 17;3:e127. doi: 10.1038/oncsis.2014.39. PubMed |
| MNKs act as a regulatory switch for eIF4E1 and eIF4E3 driven mRNA translation in DLBCL. Landon AL, Muniandy PA, Shetty AC, Lehrmann E, Volpon L, Houng S, Zhang Y, Dai B, Peroutka R, Mazan-Mamczarz K, Steinhardt J, Mahurkar A, Becker KG, Borden KL, Gartenhaus RB. Nat Commun. 2014 Nov 18;5:5413. doi: 10.1038/ncomms6413. PubMed |
| Functional implications of a psychiatric risk variant within CACNA1C in induced human neurons. Yoshimizu T, Pan JQ, Mungenast AE, Madison JM, Su S, Ketterman J, Ongur D, McPhie D, Cohen B, Perlis R, Tsai LH. Mol Psychiatry. 2015 Feb;20(2):162-9. doi: 10.1038/mp.2014.143. Epub 2014 Nov 18. PubMed |
| Silencing long noncoding RNAs with genome-editing tools. Gutschner T. Methods Mol Biol. 2015;1239:241-50. doi: 10.1007/978-1-4939-1862-1_13. PubMed |
| Andes virus nucleocapsid protein interrupts protein kinase R dimerization to counteract host interference in viral protein synthesis. Wang Z, Mir MA. J Virol. 2015 Feb;89(3):1628-39. doi: 10.1128/JVI.02347-14. Epub 2014 Nov 19. PubMed |
| Cellular differentiation regulator BLIMP1 induces Epstein-Barr virus lytic reactivation in epithelial and B cells by activating transcription from both the R and Z promoters. Reusch JA, Nawandar DM, Wright KL, Kenney SC, Mertz JE. J Virol. 2015 Feb;89(3):1731-43. doi: 10.1128/JVI.02781-14. Epub 2014 Nov 19. PubMed |
| Prediction and quantification of bioactive microbiota metabolites in the mouse gut. Sridharan GV, Choi K, Klemashevich C, Wu C, Prabakaran D, Pan LB, Steinmeyer S, Mueller C, Yousofshahi M, Alaniz RC, Lee K, Jayaraman A. Nat Commun. 2014 Nov 20;5:5492. doi: 10.1038/ncomms6492. PubMed |
| Inhibition of autophagy as a new means of improving chemotherapy efficiency in high-LC3B triple-negative breast cancers. Lefort S, Joffre C, Kieffer Y, Givel AM, Bourachot B, Zago G, Bieche I, Dubois T, Meseure D, Vincent-Salomon A, Camonis J, Mechta-Grigoriou F. Autophagy. 2014;10(12):2122-42. doi: 10.4161/15548627.2014.981788. PubMed |
| Mitochondrial DNA haplogroup B5 confers genetic susceptibility to Alzheimer's disease in Han Chinese. Bi R, Zhang W, Yu D, Li X, Wang HZ, Hu QX, Zhang C, Lu W, Ni J, Fang Y, Li T, Yao YG. Neurobiol Aging. 2015 Mar;36(3):1604.e7-16. doi: 10.1016/j.neurobiolaging.2014.10.009. Epub 2014 Oct 22. PubMed |
| A role for the mitochondrial pyruvate carrier as a repressor of the Warburg effect and colon cancer cell growth. Schell JC, Olson KA, Jiang L, Hawkins AJ, Van Vranken JG, Xie J, Egnatchik RA, Earl EG, DeBerardinis RJ, Rutter J. Mol Cell. 2014 Nov 6;56(3):400-13. doi: 10.1016/j.molcel.2014.09.026. Epub 2014 Oct 21. PubMed |
| Deficiency in the mitochondrial apoptotic pathway reveals the toxic potential of autophagy under ER stress conditions. Deegan S, Saveljeva S, Logue SE, Pakos-Zebrucka K, Gupta S, Vandenabeele P, Bertrand MJ, Samali A. Autophagy. 2014;10(11):1921-36. doi: 10.4161/15548627.2014.981790. PubMed |
| Xylosyltransferase-1 expression is refractory to inhibition by the inflammatory cytokines tumor necrosis factor alpha and IL-1beta in nucleus pulposus cells: novel regulation by AP-1, Sp1, and Sp3. Ye W, Zhou J, Markova DZ, Tian Y, Li J, Anderson DG, Shapiro IM, Risbud MV. Am J Pathol. 2015 Feb;185(2):485-95. doi: 10.1016/j.ajpath.2014.09.021. Epub 2014 Dec 2. PubMed |
| Increasing cisplatin sensitivity by schedule-dependent inhibition of AKT and Chk1. Duan L, Perez RE, Hansen M, Gitelis S, Maki CG. Cancer Biol Ther. 2014;15(12):1600-12. doi: 10.4161/15384047.2014.961876. PubMed |
| Dysregulated autophagy in the RPE is associated with increased susceptibility to oxidative stress and AMD. Mitter SK, Song C, Qi X, Mao H, Rao H, Akin D, Lewin A, Grant M, Dunn W Jr, Ding J, Bowes Rickman C, Boulton M. Autophagy. 2014;10(11):1989-2005. doi: 10.4161/auto.36184. PubMed |
| c-Src deactivation by the polyphenol 3-O-caffeoylquinic acid abrogates reactive oxygen species-mediated glutamate release from microglia and neuronal excitotoxicity. Socodato R, Portugal CC, Canedo T, Domith I, Oliveira NA, Paes-de-Carvalho R, Relvas JB, Cossenza M. Free Radic Biol Med. 2015 Feb;79:45-55. doi: 10.1016/j.freeradbiomed.2014.11.019. Epub 2014 Dec 5. PubMed |
| The neutral sphingomyelinase pathway regulates packaging of the prion protein into exosomes. Guo BB, Bellingham SA, Hill AF. J Biol Chem. 2015 Feb 6;290(6):3455-67. doi: 10.1074/jbc.M114.605253. Epub 2014 Dec 10. PubMed |
| Knockdown of the Cell Cycle Inhibitor p21 Enhances Cartilage Formation by Induced Pluripotent Stem Cells. Diekman BO, Thakore PI, O'Connor SK, Willard VP, Brunger JM, Christoforou N, Leong KW, Gersbach CA, Guilak F. Tissue Eng Part A. 2015 Apr;21(7-8):1261-74. doi: 10.1089/ten.TEA.2014.0240. Epub 2015 Jan 23. PubMed |
| Sirtuin 4 is a lipoamidase regulating pyruvate dehydrogenase complex activity. Mathias RA, Greco TM, Oberstein A, Budayeva HG, Chakrabarti R, Rowland EA, Kang Y, Shenk T, Cristea IM. Cell. 2014 Dec 18;159(7):1615-25. doi: 10.1016/j.cell.2014.11.046. PubMed |
| A THEMIS:SHP1 complex promotes T-cell survival. Paster W, Bruger AM, Katsch K, Gregoire C, Roncagalli R, Fu G, Gascoigne NR, Nika K, Cohnen A, Feller SM, Simister PC, Molder KC, Cordoba SP, Dushek O, Malissen B, Acuto O. EMBO J. 2015 Feb 3;34(3):393-409. doi: 10.15252/embj.201387725. Epub 2014 Dec 22. PubMed |
| Fanconi anemia gene editing by the CRISPR/Cas9 system. Osborn MJ, Gabriel R, Webber BR, DeFeo AP, McElroy AN, Jarjour J, Starker CG, Wagner JE, Joung JK, Voytas DF, von Kalle C, Schmidt M, Blazar BR, Tolar J. Hum Gene Ther. 2015 Feb;26(2):114-26. doi: 10.1089/hum.2014.111. PubMed |
| Reversal of Mutant KRAS-Mediated Apoptosis Resistance by Concurrent Noxa/Bik Induction and Bcl-2/Bcl-xL Antagonism in Colon Cancer Cells. Okamoto K, Zaanan A, Kawakami H, Huang S, Sinicrope FA. Mol Cancer Res. 2015 Apr;13(4):659-69. doi: 10.1158/1541-7786.MCR-14-0476. Epub 2014 Dec 29. PubMed |
| Inhibition of autophagic turnover in beta-cells by fatty acids and glucose leads to apoptotic cell death. Mir SU, George NM, Zahoor L, Harms R, Guinn Z, Sarvetnick NE. J Biol Chem. 2015 Mar 6;290(10):6071-85. doi: 10.1074/jbc.M114.605345. Epub 2014 Dec 29. PubMed |
| Role of the clathrin adaptor PICALM in normal hematopoiesis and polycythemia vera pathophysiology. Ishikawa Y, Maeda M, Pasham M, Aguet F, Tacheva-Grigorova SK, Masuda T, Yi H, Lee SU, Xu J, Teruya-Feldstein J, Ericsson M, Mullally A, Heuser J, Kirchhausen T, Maeda T. Haematologica. 2015 Apr;100(4):439-51. doi: 10.3324/haematol.2014.119537. Epub 2014 Dec 31. PubMed |
| Characterization and modeling of Ca(2+) oscillations in mouse primary mesothelial cells. Pecze L, Schwaller B. Biochim Biophys Acta. 2015 Mar;1854(3):632-45. doi: 10.1016/j.bbamcr.2014.12.025. Epub 2014 Dec 30. PubMed |
| Endoplasmic reticulum stress induces ligand-independent TNFR1-mediated necroptosis in L929 cells. Saveljeva S, Mc Laughlin SL, Vandenabeele P, Samali A, Bertrand MJ. Cell Death Dis. 2015 Jan 8;6:e1587. doi: 10.1038/cddis.2014.548. PubMed |
| Retinoid X receptors orchestrate osteoclast differentiation and postnatal bone remodeling. Menendez-Gutierrez MP, Roszer T, Fuentes L, Nunez V, Escolano A, Redondo JM, De Clerck N, Metzger D, Valledor AF, Ricote M. J Clin Invest. 2015 Feb;125(2):809-23. doi: 10.1172/JCI77186. Epub 2015 Jan 9. PubMed |
| Filamin C, a dysregulated protein in cancer revealed by label-free quantitative proteomic analyses of human gastric cancer cells. Qiao J, Cui SJ, Xu LL, Chen SJ, Yao J, Jiang YH, Peng G, Fang CY, Yang PY, Liu F. Oncotarget. 2015 Jan 20;6(2):1171-89. PubMed |
| Expression of the potential therapeutic target CXXC5 in primary acute myeloid leukemia cells - high expression is associated with adverse prognosis as well as altered intracellular signaling and transcriptional regulation. Bruserud O, Reikvam H, Fredly H, Skavland J, Hagen KM, van Hoang TT, Brenner AK, Kadi A, Astori A, Gjertsen BT, Pendino F. Oncotarget. 2015 Feb 20;6(5):2794-811. PubMed |
| A novel cytostatic form of autophagy in sensitization of non-small cell lung cancer cells to radiation by vitamin D and the vitamin D analog, EB 1089. Sharma K, Goehe RW, Di X, Hicks MA 2nd, Torti SV, Torti FM, Harada H, Gewirtz DA. Autophagy. 2014;10(12):2346-61. doi: 10.4161/15548627.2014.993283. PubMed |
| Prolyl-4-hydroxylase domain protein 2 controls NF-kappaB/p65 transactivation and enhances the catabolic effects of inflammatory cytokines on cells of the nucleus pulposus. Li J, Yuan W, Jiang S, Ye W, Yang H, Shapiro IM, Risbud MV. J Biol Chem. 2015 Mar 13;290(11):7195-207. doi: 10.1074/jbc.M114.611483. Epub 2015 Jan 29. PubMed |
| YAP-mediated induction of monoacylglycerol lipase restrains oncogenic transformation. Tang ED, Wang CY. Cell Signal. 2015 Apr;27(4):836-40. doi: 10.1016/j.cellsig.2015.01.011. Epub 2015 Jan 28. PubMed |
| Production and use of lentivirus to selectively transduce primary oligodendrocyte precursor cells for in vitro myelination assays. Peckham HM, Ferner AH, Giuffrida L, Murray SS, Xiao J. J Vis Exp. 2015 Jan 12;(95):52179. doi: 10.3791/52179. PubMed |
| FoxO3a suppresses the senescence of cardiac microvascular endothelial cells by regulating the ROS-mediated cell cycle. Qi XF, Chen ZY, Xia JB, Zheng L, Zhao H, Pi LQ, Park KS, Kim SK, Lee KJ, Cai DQ. J Mol Cell Cardiol. 2015 Apr;81:114-26. doi: 10.1016/j.yjmcc.2015.01.022. Epub 2015 Feb 2. PubMed |
| UBE3C promotes growth and metastasis of renal cell carcinoma via activating Wnt/beta-catenin pathway. Wen JL, Wen XF, Li RB, Jin YC, Wang XL, Zhou L, Chen HX. PLoS One. 2015 Feb 6;10(2):e0115622. doi: 10.1371/journal.pone.0115622. eCollection 2015. PubMed |
| DNA damage-induced regulatory interplay between DAXX, p53, ATM kinase and Wip1 phosphatase. Brazina J, Svadlenka J, Macurek L, Andera L, Hodny Z, Bartek J, Hanzlikova H. Cell Cycle. 2015;14(3):375-87. doi: 10.4161/15384101.2014.988019. PubMed |
| Lysyl hydroxylase 2 induces a collagen cross-link switch in tumor stroma. Chen Y, Terajima M, Yang Y, Sun L, Ahn YH, Pankova D, Puperi DS, Watanabe T, Kim MP, Blackmon SH, Rodriguez J, Liu H, Behrens C, Wistuba II, Minelli R, Scott KL, Sanchez-Adams J, Guilak F, Pati D, Thilaganathan N, Burns AR, Creighton CJ, Martinez ED, Zal T, Grande-Allen KJ, Yamauchi M, Kurie JM. J Clin Invest. 2015 Mar 2;125(3):1147-62. doi: 10.1172/JCI74725. Epub 2015 Feb 9. PubMed |
| The functional interactome of PYHIN immune regulators reveals IFIX is a sensor of viral DNA. Diner BA, Li T, Greco TM, Crow MS, Fuesler JA, Wang J, Cristea IM. Mol Syst Biol. 2015 Feb 9;11(1):787. doi: 10.15252/msb.20145808. PubMed |
| PROX1 promotes hepatocellular carcinoma proliferation and sorafenib resistance by enhancing beta-catenin expression and nuclear translocation. Liu Y, Ye X, Zhang JB, Ouyang H, Shen Z, Wu Y, Wang W, Wu J, Tao S, Yang X, Qiao K, Zhang J, Liu J, Fu Q, Xie Y. Oncogene. 2015 Feb 16. doi: 10.1038/onc.2015.7. PubMed |
| Cryopreservation of microencapsulated murine mesenchymal stem cells genetically engineered to secrete erythropoietin. Gurruchaga H, Ciriza J, Saenz Del Burgo L, Rodriguez-Madoz JR, Santos E, Prosper F, Hernandez RM, Orive G, Pedraz JL. Int J Pharm. 2015 May 15;485(1-2):15-24. doi: 10.1016/j.ijpharm.2015.02.047. Epub 2015 Feb 20. PubMed |
| ICAM1 depletion reduces spinal metastasis formation in vivo and improves neurological outcome. Broggini T, Czabanka M, Piffko A, Harms C, Hoffmann C, Mrowka R, Wenke F, Deutsch U, Grotzinger C, Vajkoczy P. Eur Spine J. 2015 Feb 25. PubMed |
Novel lentiviral-inducible transgene expression systems and versatile single-plasmid reporters for in vitro and in vivo cancer biology studies.
Shuen WH, Kan R, Yu Z, Lung HL, Lung ML.
Cancer Gene Ther. 2015 Feb 27. doi: 10.1038/cgt.2015.9.
PubMed
Associated Plasmids |
| MicroRNA-22 regulates smooth muscle cell differentiation from stem cells by targeting methyl CpG-binding protein 2. Zhao H, Wen G, Huang Y, Yu X, Chen Q, Afzal TA, Luong le A, Zhu J, Ye S, Zhang L, Xiao Q. Arterioscler Thromb Vasc Biol. 2015 Apr;35(4):918-29. doi: 10.1161/ATVBAHA.114.305212. Epub 2015 Feb 26. PubMed |
| Potent degradation of neuronal miRNAs induced by highly complementary targets. de la Mata M, Gaidatzis D, Vitanescu M, Stadler MB, Wentzel C, Scheiffele P, Filipowicz W, Grosshans H. EMBO Rep. 2015 Apr;16(4):500-11. doi: 10.15252/embr.201540078. Epub 2015 Feb 27. PubMed |
Highly efficient Cas9-mediated transcriptional programming.
Chavez A, Scheiman J, Vora S, Pruitt BW, Tuttle M, P R Iyer E, Lin S, Kiani S, Guzman CD, Wiegand DJ, Ter-Ovanesyan D, Braff JL, Davidsohn N, Housden BE, Perrimon N, Weiss R, Aach J, Collins JJ, Church GM.
Nat Methods. 2015 Mar 2. doi: 10.1038/nmeth.3312.
PubMed
Associated Plasmids |
| Fatty acid elongase 7 catalyzes lipidome remodeling essential for human cytomegalovirus replication. Purdy JG, Shenk T, Rabinowitz JD. Cell Rep. 2015 Mar 3;10(8):1375-85. doi: 10.1016/j.celrep.2015.02.003. Epub 2015 Feb 26. PubMed |
| Stemness factor Sall4 is required for DNA damage response in embryonic stem cells. Xiong J, Todorova D, Su NY, Kim J, Lee PJ, Shen Z, Briggs SP, Xu Y. J Cell Biol. 2015 Mar 2;208(5):513-20. doi: 10.1083/jcb.201408106. PubMed |
| Rad51-mediated replication fork reversal is a global response to genotoxic treatments in human cells. Zellweger R, Dalcher D, Mutreja K, Berti M, Schmid JA, Herrador R, Vindigni A, Lopes M. J Cell Biol. 2015 Mar 2;208(5):563-79. doi: 10.1083/jcb.201406099. PubMed |
| CD47 agonist peptides induce programmed cell death in refractory chronic lymphocytic leukemia B cells via PLCgamma1 activation: evidence from mice and humans. Martinez-Torres AC, Quiney C, Attout T, Boullet H, Herbi L, Vela L, Barbier S, Chateau D, Chapiro E, Nguyen-Khac F, Davi F, Le Garff-Tavernier M, Moumne R, Sarfati M, Karoyan P, Merle-Beral H, Launay P, Susin SA. PLoS Med. 2015 Mar 3;12(3):e1001796. doi: 10.1371/journal.pmed.1001796. eCollection 2015 Mar. PubMed |
| DNA damage shifts circadian clock time via Hausp-dependent Cry1 stabilization. Papp SJ, Huber AL, Jordan SD, Kriebs A, Nguyen M, Moresco JJ, Yates JR, Lamia KA. Elife. 2015 Mar 10;4. doi: 10.7554/eLife.04883. PubMed |
Plexin-B2 promotes invasive growth of malignant glioma.
Le AP, Huang Y, Pingle SC, Kesari S, Wang H, Yong RL, Zou H, Friedel RH.
Oncotarget. 2015 Mar 30;6(9):7293-304.
PubMed
Associated Plasmids |
| NIK is required for NF-kappaB-mediated induction of BAG3 upon inhibition of constitutive protein degradation pathways. Rapino F, Abhari BA, Jung M, Fulda S. Cell Death Dis. 2015 Mar 12;6:e1692. doi: 10.1038/cddis.2014.584. PubMed |
| Selective Distal Enhancer Control of the Mmp13 Gene Identified through Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR) Genomic Deletions. Meyer MB, Benkusky NA, Pike JW. J Biol Chem. 2015 Apr 24;290(17):11093-107. doi: 10.1074/jbc.M115.648394. Epub 2015 Mar 15. PubMed |
| IFI44 suppresses HIV-1 LTR promoter activity and facilitates its latency. Power D, Santoso N, Dieringer M, Yu J, Huang H, Simpson S, Seth I, Miao H, Zhu J. Virology. 2015 Jul;481:142-50. doi: 10.1016/j.virol.2015.02.046. Epub 2015 Mar 14. PubMed |
| miR-191 promotes tumorigenesis of human colorectal cancer through targeting C/EBPbeta. Zhang XF, Li KK, Gao L, Li SZ, Chen K, Zhang JB, Wang D, Tu RF, Zhang JX, Tao KX, Wang G, Zhang XD. Oncotarget. 2015 Feb 28;6(6):4144-58. PubMed |
| Modeling and study of the mechanism of dilated cardiomyopathy using induced pluripotent stem cells derived from individuals with Duchenne muscular dystrophy. Lin B, Li Y, Han L, Kaplan AD, Ao Y, Kalra S, Bett GC, Rasmusson RL, Denning C, Yang L. Dis Model Mech. 2015 May;8(5):457-66. doi: 10.1242/dmm.019505. Epub 2015 Mar 19. PubMed |
| Borna disease virus phosphoprotein modulates epigenetic signaling in neurons to control viral replication. Bonnaud EM, Szelechowski M, Betourne A, Foret C, Thouard A, Gonzalez-Dunia D, Malnou CE. J Virol. 2015 Jun;89(11):5996-6008. doi: 10.1128/JVI.00454-15. Epub 2015 Mar 25. PubMed |
| Sustained regeneration of high-volume adipose tissue for breast reconstruction using computer aided design and biomanufacturing. Chhaya MP, Melchels FP, Holzapfel BM, Baldwin JG, Hutmacher DW. Biomaterials. 2015 Jun;52:551-60. doi: 10.1016/j.biomaterials.2015.01.025. Epub 2015 Mar 18. PubMed |
| CCM2-CCM3 interaction stabilizes their protein expression and permits endothelial network formation. Draheim KM, Li X, Zhang R, Fisher OS, Villari G, Boggon TJ, Calderwood DA. J Cell Biol. 2015 Mar 30;208(7):987-1001. doi: 10.1083/jcb.201407129. PubMed |
| TGF-beta suppression of HBV RNA through AID-dependent recruitment of an RNA exosome complex. Liang G, Liu G, Kitamura K, Wang Z, Chowdhury S, Monjurul AM, Wakae K, Koura M, Shimadu M, Kinoshita K, Muramatsu M. PLoS Pathog. 2015 Apr 2;11(4):e1004780. doi: 10.1371/journal.ppat.1004780. eCollection 2015 Apr. PubMed |
| Caveolin-1 is transcribed from a hypermethylated promoter to mediate colonocyte differentiation and apoptosis. Dasgupta N, Kumar Thakur B, Ta A, Das S. Exp Cell Res. 2015 Jun 10;334(2):323-36. doi: 10.1016/j.yexcr.2015.03.020. Epub 2015 Apr 1. PubMed |
Rationally Designed MicroRNA-Based Genetic Classifiers Target Specific Neurons in the Brain.
Sayeg MK, Weinberg BH, Cha SS, Goodloe M, Wong WW, Han X.
ACS Synth Biol. 2015 Apr 13.
PubMed
Associated Plasmids |
| Repeated ER-endosome contacts promote endosome translocation and neurite outgrowth. Raiborg C, Wenzel EM, Pedersen NM, Olsvik H, Schink KO, Schultz SW, Vietri M, Nisi V, Bucci C, Brech A, Johansen T, Stenmark H. Nature. 2015 Apr 9;520(7546):234-8. doi: 10.1038/nature14359. PubMed |
| Latent transforming growth factor-beta binding proteins (LTBP-1 and LTBP-2) and gingiva keratinization. Chiang MS, Yang JR, Liao SC, Hsu CC, Hsu CW, Yuan K. Oral Dis. 2015 Apr 10. doi: 10.1111/odi.12344. PubMed |
| Methods of Reprogramming to Induced Pluripotent Stem Cell Associated with Chromosomal Integrity and Delineation of a Chromosome 5q Candidate Region for Growth Advantage. Sobol M, Raykova D, Cavelier L, Khalfallah A, Schuster J, Dahl N. Stem Cells Dev. 2015 Sep 1;24(17):2032-40. doi: 10.1089/scd.2015.0061. Epub 2015 May 18. PubMed |
| A pooled shRNA screen for regulators of primary mammary stem and progenitor cells identifies roles for Asap1 and Prox1. Sheridan JM, Ritchie ME, Best SA, Jiang K, Beck TJ, Vaillant F, Liu K, Dickins RA, Smyth GK, Lindeman GJ, Visvader JE. BMC Cancer. 2015 Apr 3;15:221. doi: 10.1186/s12885-015-1187-z. PubMed |
| alpha6beta1- and alphaV-integrins are required for long-term self-renewal of murine embryonic stem cells in the absence of LIF. Cattavarayane S, Palovuori R, Tanjore Ramanathan J, Manninen A. BMC Cell Biol. 2015 Feb 27;16:3. doi: 10.1186/s12860-015-0051-y. PubMed |
| Loss of GM130 in breast cancer cells and its effects on cell migration, invasion and polarity. Baschieri F, Uetz-von Allmen E, Legler DF, Farhan H. Cell Cycle. 2015;14(8):1139-47. doi: 10.1080/15384101.2015.1007771. PubMed |
| Quantification of cell fusion events human breast cancer cells and breast epithelial cells using a Cre-LoxP-based double fluorescence reporter system. Mohr M, Tosun S, Arnold WH, Edenhofer F, Zanker KS, Dittmar T. Cell Mol Life Sci. 2015 Apr 22. PubMed |
| Single-step cloning-screening method: a new tool for developing and studying high-titer viral vector producer cells. Rodrigues AF, Formas-Oliveira AS, Guerreiro MR, Tomas HA, Alves PM, Coroadinha AS. Gene Ther. 2015 Sep;22(9):685-95. doi: 10.1038/gt.2015.44. Epub 2015 May 4. PubMed |
| Viral-mediated Labeling and Transplantation of Medial Ganglionic Eminence (MGE) Cells for In Vivo Studies. Vogt D, Wu PR, Sorrells SF, Arnold C, Alvarez-Buylla A, Rubenstein JL. J Vis Exp. 2015 Apr 23;(98). doi: 10.3791/52740. PubMed |
| An alternative pluripotent state confers interspecies chimaeric competency. Wu J, Okamura D, Li M, Suzuki K, Luo C, Ma L, He Y, Li Z, Benner C, Tamura I, Krause MN, Nery JR, Du T, Zhang Z, Hishida T, Takahashi Y, Aizawa E, Kim NY, Lajara J, Guillen P, Campistol JM, Esteban CR, Ross PJ, Saghatelian A, Ren B, Ecker JR, Izpisua Belmonte JC. Nature. 2015 May 21;521(7552):316-21. doi: 10.1038/nature14413. Epub 2015 May 6. PubMed |
| Overexpression of the Promigratory and Prometastatic PTK7 Receptor Is Associated with an Adverse Clinical Outcome in Colorectal Cancer. Lhoumeau AC, Martinez S, Boher JM, Monges G, Castellano R, Goubard A, Doremus M, Poizat F, Lelong B, de Chaisemartin C, Bardin F, Viens P, Raoul JL, Prebet T, Aurrand-Lions M, Borg JP, Goncalves A. PLoS One. 2015 May 11;10(5):e0123768. doi: 10.1371/journal.pone.0123768. eCollection 2015. PubMed |
| Inhibition of histone methyltransferases SUV39H1 and G9a leads to neuroprotection in an in vitro model of cerebral ischemia. Schweizer S, Harms C, Lerch H, Flynn J, Hecht J, Yildirim F, Meisel A, Marschenz S. J Cereb Blood Flow Metab. 2015 May 13. doi: 10.1038/jcbfm.2015.99. PubMed |
| Reduced efficiency of sarcolipin-dependent respiration in myocytes from humans with severe obesity. Paran CW, Verkerke AR, Heden TD, Park S, Zou K, Lawson HA, Song H, Turk J, Houmard JA, Funai K. Obesity (Silver Spring). 2015 Jul;23(7):1440-9. doi: 10.1002/oby.21123. Epub 2015 May 13. PubMed |
| Mechanisms of clonal evolution in childhood acute lymphoblastic leukemia. Swaminathan S, Klemm L, Park E, Papaemmanuil E, Ford A, Kweon SM, Trageser D, Hasselfeld B, Henke N, Mooster J, Geng H, Schwarz K, Kogan SC, Casellas R, Schatz DG, Lieber MR, Greaves MF, Muschen M. Nat Immunol. 2015 Jul;16(7):766-74. doi: 10.1038/ni.3160. Epub 2015 May 18. PubMed |
| Regulation of autophagic cell death by glycogen synthase kinase-3beta in adult hippocampal neural stem cells following insulin withdrawal. Ha S, Ryu HY, Chung KM, Baek SH, Kim EK, Yu SW. Mol Brain. 2015 May 19;8:30. doi: 10.1186/s13041-015-0119-9. PubMed |
| The schizophrenia risk gene product miR-137 alters presynaptic plasticity. Siegert S, Seo J, Kwon EJ, Rudenko A, Cho S, Wang W, Flood Z, Martorell AJ, Ericsson M, Mungenast AE, Tsai LH. Nat Neurosci. 2015 Jul;18(7):1008-16. doi: 10.1038/nn.4023. Epub 2015 May 25. PubMed |
| Generation of X-CGD cells for vector evaluation from healthy donor CD34(+) HSCs by shRNA-mediated knock down of gp91(phox). Brendel C, Kaufmann KB, Krattenmacher A, Pahujani S, Grez M. Mol Ther Methods Clin Dev. 2014 Aug 27;1:14037. doi: 10.1038/mtm.2014.37. eCollection 2014. PubMed |
| Comparative analysis of lentiviral vectors and modular protein nanovectors for traumatic brain injury gene therapy. Negro-Demontel ML, Saccardo P, Giacomini C, Yanez-Munoz RJ, Ferrer-Miralles N, Vazquez E, Villaverde A, Peluffo H. Mol Ther Methods Clin Dev. 2014 Oct 15;1:14047. doi: 10.1038/mtm.2014.47. eCollection 2014. PubMed |
| Death of Neurons following Injury Requires Conductive Neuronal Gap Junction Channels but Not a Specific Connexin. Fontes JD, Ramsey J, Polk JM, Koop A, Denisova JV, Belousov AB. PLoS One. 2015 May 27;10(5):e0125395. doi: 10.1371/journal.pone.0125395. eCollection 2015. PubMed |
| Coronary Artery Disease Associated Transcription Factor TCF21 Regulates Smooth Muscle Precursor Cells That Contribute to the Fibrous Cap. Nurnberg ST, Cheng K, Raiesdana A, Kundu R, Miller CL, Kim JB, Arora K, Carcamo-Oribe I, Xiong Y, Tellakula N, Nanda V, Murthy N, Boisvert WA, Hedin U, Perisic L, Aldi S, Maegdefessel L, Pjanic M, Owens GK, Tallquist MD, Quertermous T. PLoS Genet. 2015 May 28;11(5):e1005155. doi: 10.1371/journal.pgen.1005155. eCollection 2015 May. PubMed |
| Human Induced Pluripotent Stem Cell-Derived Microvesicles Transmit RNAs and Proteins to Recipient Mature Heart Cells Modulating Cell Fate and Behavior. Bobis-Wozowicz S, Kmiotek K, Sekula M, Kedracka-Krok S, Kamycka E, Adamiak M, Jankowska U, Madetko-Talowska A, Sarna M, Bik-Multanowski M, Kolcz J, Boruczkowski D, Madeja Z, Dawn B, Zuba-Surma EK. Stem Cells. 2015 Jun 1. doi: 10.1002/stem.2078. PubMed |
| E2F1-Mediated Induction of NFYB Attenuates Apoptosis via Joint Regulation of a Pro-Survival Transcriptional Program. Jiang X, Nevins JR, Shats I, Chi JT. PLoS One. 2015 Jun 3;10(6):e0127951. doi: 10.1371/journal.pone.0127951. eCollection 2015. PubMed |
Akt signaling dynamics in individual cells.
Gross SM, Rotwein P.
J Cell Sci. 2015 Jun 3. pii: jcs.168773.
PubMed
Associated Plasmids |
| Lentiviral transduction of mammary epithelial cells. Iggo R, Richard E. Methods Mol Biol. 2015;1293:137-60. doi: 10.1007/978-1-4939-2519-3_8. PubMed |
| Spastin and ESCRT-III coordinate mitotic spindle disassembly and nuclear envelope sealing. Vietri M, Schink KO, Campsteijn C, Wegner CS, Schultz SW, Christ L, Thoresen SB, Brech A, Raiborg C, Stenmark H. Nature. 2015 Jun 11;522(7555):231-5. doi: 10.1038/nature14408. Epub 2015 Jun 3. PubMed |
| Reprogramming fibroblasts toward cardiomyocytes, neural stem cells and hepatocytes by cell activation and signaling-directed lineage conversion. Zhu S, Wang H, Ding S. Nat Protoc. 2015 Jul;10(7):959-73. doi: 10.1038/nprot.2015.059. Epub 2015 Jun 4. PubMed |
| Forward Programming of Cardiac Stem Cells by Homogeneous Transduction with MYOCD plus TBX5. Belian E, Noseda M, Abreu Paiva MS, Leja T, Sampson R, Schneider MD. PLoS One. 2015 Jun 5;10(6):e0125384. doi: 10.1371/journal.pone.0125384. eCollection 2015. PubMed |
| Evidence that synthetic lethality underlies the mutual exclusivity of oncogenic KRAS and EGFR mutations in lung adenocarcinoma. Unni AM, Lockwood WW, Zejnullahu K, Lee-Lin SQ, Varmus H. Elife. 2015 Jun 5;4:e06907. doi: 10.7554/eLife.06907. PubMed |
| Decoy receptors block TRAIL sensitivity at a supracellular level: the role of stromal cells in controlling tumour TRAIL sensitivity. O'Leary L, van der Sloot AM, Reis CR, Deegan S, Ryan AE, Dhami SP, Murillo LS, Cool RH, de Sampaio PC, Thompson K, Murphy G, Quax WJ, Serrano L, Samali A, Szegezdi E. Oncogene. 2015 Jun 8. doi: 10.1038/onc.2015.180. PubMed |
| Identification of bromodomain-containing protein-4 as a novel marker and epigenetic target in mast cell leukemia. Wedeh G, Cerny-Reiterer S, Eisenwort G, Herrmann H, Blatt K, Hadzijusufovic E, Sadovnik I, Mullauer L, Schwaab J, Hoffmann T, Bradner JE, Radia D, Sperr WR, Hoermann G, Reiter A, Horny HP, Zuber J, Arock M, Valent P. Leukemia. 2015 Jun 9. doi: 10.1038/leu.2015.138. PubMed |
| Tryptophan derivatives regulate the transcription of Oct4 in stem-like cancer cells. Cheng J, Li W, Kang B, Zhou Y, Song J, Dan S, Yang Y, Zhang X, Li J, Yin S, Cao H, Yao H, Zhu C, Yi W, Zhao Q, Xu X, Zheng M, Zheng S, Li L, Shen B, Wang YJ. Nat Commun. 2015 Jun 10;6:7209. doi: 10.1038/ncomms8209. PubMed |
| MYBL2 guides autophagy suppressor VDAC2 in the developing ovary to inhibit autophagy through a complex of VDAC2-BECN1-BCL2L1 in mammals. Yuan J, Zhang Y, Sheng Y, Fu X, Cheng H, Zhou R. Autophagy. 2015;11(7):1081-98. doi: 10.1080/15548627.2015.1040970. PubMed |
| Arylsulfatase A Overexpressing Human iPSC-derived Neural Cells Reduce CNS Sulfatide Storage in a Mouse Model of Metachromatic Leukodystrophy. Doerr J, Bockenhoff A, Ewald B, Ladewig J, Eckhardt M, Gieselmann V, Matzner U, Brustle O, Koch P. Mol Ther. 2015 Jun 10. doi: 10.1038/mt.2015.106. PubMed |
| Lysine-specific demethylase (LSD1/KDM1A) and MYCN cooperatively repress tumor suppressor genes in neuroblastoma. Amente S, Milazzo G, Sorrentino MC, Ambrosio S, Di Palo G, Lania L, Perini G, Majello B. Oncotarget. 2015 Jun 10;6(16):14572-83. PubMed |
| Transcriptional co-factor Transducin beta-like (TBL) 1 acts as a checkpoint in pancreatic cancer malignancy. Stoy C, Sundaram A, Rios Garcia M, Wang X, Seibert O, Zota A, Wendler S, Mannle D, Hinz U, Sticht C, Muciek M, Gretz N, Rose AJ, Greiner V, Hofmann TG, Bauer A, Hoheisel J, Berriel Diaz M, Gaida MM, Werner J, Schafmeier T, Strobel O, Herzig S. EMBO Mol Med. 2015 Jun 12;7(8):1048-62. doi: 10.15252/emmm.201404837. PubMed |
| Parkinson-causing alpha-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation. Dettmer U, Newman AJ, Soldner F, Luth ES, Kim NC, von Saucken VE, Sanderson JB, Jaenisch R, Bartels T, Selkoe D. Nat Commun. 2015 Jun 16;6:7314. doi: 10.1038/ncomms8314. PubMed |
| Lhx8 mediated Wnt and TGFbeta pathways in tooth development and regeneration. Zhou C, Yang G, Chen M, Wang C, He L, Xiang L, Chen D, Ling J, Mao JJ. Biomaterials. 2015 Sep;63:35-46. doi: 10.1016/j.biomaterials.2015.06.004. Epub 2015 Jun 3. PubMed |
| Binding of the sphingolipid S1P to hTERT stabilizes telomerase at the nuclear periphery by allosterically mimicking protein phosphorylation. Panneer Selvam S, De Palma RM, Oaks JJ, Oleinik N, Peterson YK, Stahelin RV, Skordalakes E, Ponnusamy S, Garrett-Mayer E, Smith CD, Ogretmen B. Sci Signal. 2015 Jun 16;8(381):ra58. doi: 10.1126/scisignal.aaa4998. PubMed |
| Pellino-1 positively regulates Toll-like Receptor (TLR) 2 and TLR4 signaling and is suppressed upon induction of endotoxin tolerance. Murphy M, Xiong Y, Pattabiraman G, Qiu F, Medvedev AE. J Biol Chem. 2015 Jun 16. pii: jbc.M115.640128. PubMed |
| The ORF61 protein encoded by Simian Varicella Virus and Varicella Zoster Virus inhibits NFkappaB signaling by interfering with IkappaBalpha degradation. Whitmer T, Malouli D, Uebelhoer LS, DeFilippis VR, Fruh K, Verweij MC. J Virol. 2015 Jun 17. pii: JVI.01149-15. PubMed |
| Induction of functional Brm protein from Brm knockout mice. Thompson KW, Marquez SB, Lu L, Reisman D. Oncoscience. 2015 Apr 18;2(4):349-61. eCollection 2015. PubMed |
| IGF1R/IRS1 signaling confers pathogenic activity on breast tumor cells lacking REST. Meyer K, Albaugh B, Schoenike B, Roopra A. Mol Cell Biol. 2015 Jun 22. pii: MCB.01149-14. PubMed |
| Expression of the multidrug transporter P-glycoprotein is inversely related to that of apoptosis-associated endogenous TRAIL. Souza PS, Madigan JP, Gillet JP, Kapoor K, Ambudkar SV, Maia RC, Gottesman MM, Leung Fung K. Exp Cell Res. 2015 Jun 19. pii: S0014-4827(15)30013-6. doi: 10.1016/j.yexcr.2015.06.005. PubMed |
| CRISPR-mediated genotypic and phenotypic correction of a chronic granulomatous disease mutation in human iPS cells. Flynn R, Grundmann A, Renz P, Hanseler W, James WS, Cowley SA, Moore MD. Exp Hematol. 2015 Oct;43(10):838-848.e3. doi: 10.1016/j.exphem.2015.06.002. Epub 2015 Jun 19. PubMed |
| Lack of Rybp in Mouse Embryonic Stem Cells Impairs Cardiac Differentiation. Ujhelly O, Szabo V, Kovacs G, Vajda F, Mallok S, Prorok J, Acsai K, Hegedus Z, Krebs S, Dinnyes A, Pirity MK. Stem Cells Dev. 2015 Jun 25. PubMed |
| mPGES-1 in prostate cancer controls stemness and amplifies EGFR-driven oncogenicity. Finetti F, Terzuoli E, Giachetti A, Santi R, Villari D, Hanaka H, Radmark O, Ziche M, Donnini S. Endocr Relat Cancer. 2015 Jun 25. pii: ERC-15-0277. PubMed |
| Early growth response gene (EGR)-1 regulates leukotriene D4-induced cytokine transcription in Hodgkin lymphoma cells. Han H, Xue-Franzen Y, Miao X, Nagy E, Li N, Xu D, Sjoberg J, Bjorkholm M, Claesson HE. Prostaglandins Other Lipid Mediat. 2015 Jun 23. pii: S1098-8823(15)00075-1. doi: 10.1016/j.prostaglandins.2015.06.004. PubMed |
| DEAD-box RNA helicase DDX23 modulates glioma malignancy via elevating miR-21 biogenesis. Yin J, Park G, Lee JE, Choi EY, Park JY, Kim TH, Park N, Jin X, Jung JE, Shin D, Hong JH, Kim H, Yoo H, Lee SH, Kim YJ, Park JB, Kim JH. Brain. 2015 Sep;138(Pt 9):2553-70. doi: 10.1093/brain/awv167. Epub 2015 Jun 29. PubMed |
| MicroRNA-665 Regulates Dentinogenesis through MicroRNA-Mediated Silencing and Epigenetic Mechanisms. Heair HM, Kemper AG, Roy B, Lopes HB, Rashid H, Clarke JC, Afreen LK, Ferraz E, Kim E, Javed A, Beloti M, MacDougall M, Hassan M. Mol Cell Biol. 2015 Jun 29. pii: MCB.00093-15. PubMed |
| Gene Silencing by RNAi in Mammalian Cells. Ponthan F, Yusoff NM, Soria NM, Heidenreich O, Coffey K. Curr Protoc Mol Biol. 2015 Jul 1;111:26.2.1-26.2.17. doi: 10.1002/0471142727.mb2602s111. PubMed |
| Increased titer and reduced lactate accumulation in recombinant retrovirus production through the down-regulation of HIF1 and PDK. Rodrigues AF, Guerreiro MR, Formas-Oliveira AS, Fernandes P, Blechert AK, Genzel Y, Alves PM, Hu WS, Coroadinha AS. Biotechnol Bioeng. 2015 Jul 1. doi: 10.1002/bit.25691. PubMed |
| ATP binding by NLRP7 is required for inflammasome activation in response to bacterial lipopeptides. Radian AD, Khare S, Chu LH, Dorfleutner A, Stehlik C. Mol Immunol. 2015 Jul 1. pii: S0161-5890(15)00437-X. doi: 10.1016/j.molimm.2015.06.013. PubMed |
NKX2-5 mutations causative for congenital heart disease retain functionality and are directed to hundreds of targets.
Bouveret R, Waardenberg AJ, Schonrock N, Ramialison M, Doan T, de Jong D, Bondue A, Kaur G, Mohamed S, Fonoudi H, Chen CM, Wouters MA, Bhattacharya S, Plachta N, Dunwoodie SL, Chapman G, Blanpain C, Harvey RP.
Elife. 2015 Jul 6;4. doi: 10.7554/eLife.06942.
PubMed
Associated Plasmids |
| LMAN1 (ERGIC-53) is a potential carrier protein for matrix metalloproteinase-9 glycoprotein secretion. Duellman T, Burnett J, Shin A, Yang J. Biochem Biophys Res Commun. 2015 Jul 3. pii: S0006-291X(15)30222-9. doi: 10.1016/j.bbrc.2015.06.164. PubMed |
| Myogenic induction of adult and pluripotent stem cells using recombinant proteins. Perini I, Elia I, Lo Nigro A, Ronzoni F, Berardi E, Grosemans H, Fukada S, Sampaolesi M. Biochem Biophys Res Commun. 2015 Aug 28;464(3):755-61. doi: 10.1016/j.bbrc.2015.07.022. Epub 2015 Jul 8. PubMed |
| Use of Ferritin Expression, Regulated by Neural Cell-Specific Promoters in Human Adipose Tissue-Derived Mesenchymal Stem Cells, to Monitor Differentiation with Magnetic Resonance Imaging In Vitro. Song C, Wang J, Mo C, Mu S, Jiang X, Li X, Zhong S, Zhao Z, Zhou G. PLoS One. 2015 Jul 15;10(7):e0132480. doi: 10.1371/journal.pone.0132480. eCollection 2015. PubMed |
| Exosome-mediated microRNA signaling from breast cancer cells is altered by the anti-angiogenesis agent docosahexaenoic acid (DHA). Hannafon BN, Carpenter KJ, Berry WL, Janknecht R, Dooley WC, Ding WQ. Mol Cancer. 2015 Jul 16;14:133. doi: 10.1186/s12943-015-0400-7. PubMed |
| Mutant p53-R273H mediates cancer cell survival and anoikis resistance through AKT-dependent suppression of BCL2-modifying factor (BMF). Tan BS, Tiong KH, Choo HL, Chung FF, Hii LW, Tan SH, Yap IK, Pani S, Khor NT, Wong SF, Rosli R, Cheong SK, Leong CO. Cell Death Dis. 2015 Jul 16;6:e1826. doi: 10.1038/cddis.2015.191. PubMed |
| Expression of an estrogen-regulated variant transcript of the peroxisomal branched chain fatty acid oxidase ACOX2 in breast carcinomas. Bjorklund SS, Kristensen VN, Seiler M, Kumar S, Alnaes GI, Ming Y, Kerrigan J, Naume B, Sachidanandam R, Bhanot G, Borresen-Dale AL, Ganesan S. BMC Cancer. 2015 Jul 17;15:524. doi: 10.1186/s12885-015-1510-8. PubMed |
| Overexpression of the MRI Reporter Genes Ferritin and Transferrin Receptor Affect Iron Homeostasis and Produce Limited Contrast in Mesenchymal Stem Cells. Pereira SM, Moss D, Williams SR, Murray P, Taylor A. Int J Mol Sci. 2015 Jul 8;16(7):15481-96. doi: 10.3390/ijms160715481. PubMed |
| A Genome-wide CRISPR Screen in Primary Immune Cells to Dissect Regulatory Networks. Parnas O, Jovanovic M, Eisenhaure TM, Herbst RH, Dixit A, Ye CJ, Przybylski D, Platt RJ, Tirosh I, Sanjana NE, Shalem O, Satija R, Raychowdhury R, Mertins P, Carr SA, Zhang F, Hacohen N, Regev A. Cell. 2015 Jul 30;162(3):675-86. doi: 10.1016/j.cell.2015.06.059. Epub 2015 Jul 16. PubMed |
| Spontaneous Cell Competition in Immortalized Mammalian Cell Lines. Penzo-Mendez AI, Chen YJ, Li J, Witze ES, Stanger BZ. PLoS One. 2015 Jul 22;10(7):e0132437. doi: 10.1371/journal.pone.0132437. eCollection 2015. PubMed |
| Polarity Protein Scrib Facilitates Endothelial Inflammatory Signaling. Kruse C, Kurz AR, Palfi K, Humbert PO, Sperandio M, Brandes RP, Fork C, Michaelis UR. Arterioscler Thromb Vasc Biol. 2015 Sep;35(9):1954-62. doi: 10.1161/ATVBAHA.115.305678. Epub 2015 Jul 23. PubMed |
| RhoB upregulation leads to either apoptosis or cytostasis through differential target selection. Marlow LA, Bok I, Smallridge RC, Copland JA. Endocr Relat Cancer. 2015 Oct;22(5):777-92. doi: 10.1530/ERC-14-0302. Epub 2015 Jul 23. PubMed |
| The role of frataxin in doxorubicin-mediated cardiac hypertrophy. Mouli S, Nanayakkara G, AlAlasmari A, Eldoumani H, Fu X, Berlin A, Lohani M, Nie B, Arnold RD, Kavazis A, Smith F, Beyers R, Denney T, Dhanasekaran M, Zhong J, Quindry J, Amin R. Am J Physiol Heart Circ Physiol. 2015 Sep;309(5):H844-59. doi: 10.1152/ajpheart.00182.2015. Epub 2015 Jul 24. PubMed |
Adhesion to fibronectin regulates Hippo signaling via the FAK-Src-PI3K pathway.
Kim NG, Gumbiner BM.
J Cell Biol. 2015 Aug 3;210(3):503-15. doi: 10.1083/jcb.201501025. Epub 2015 Jul 27.
PubMed
Associated Plasmids |
| alpha-5 Laminin Synthesized by Human Pluripotent Stem Cells Promotes Self-Renewal. Laperle A, Hsiao C, Lampe M, Mortier J, Saha K, Palecek SP, Masters KS. Stem Cell Reports. 2015 Aug 11;5(2):195-206. doi: 10.1016/j.stemcr.2015.06.009. Epub 2015 Jul 30. PubMed |
| Scalable Electrophysiological Investigation of iPS Cell-Derived Cardiomyocytes Obtained by a Lentiviral Purification Strategy. Friedrichs S, Malan D, Voss Y, Sasse P. J Clin Med. 2015 Jan 8;4(1):102-23. doi: 10.3390/jcm4010102. PubMed |
Genetic determinants of FOXM1 overexpression in epithelial ovarian cancer and functional contribution to cell cycle progression.
Barger CJ, Zhang W, Hillman J, Stablewski AB, Higgins MJ, Vanderhyden BC, Odunsi K, Karpf AR.
Oncotarget. 2015 Jul 16.
PubMed
Associated Plasmids |
| The Mutant KRAS Gene Up-regulates BCL-XL Protein via STAT3 to Confer Apoptosis Resistance That Is Reversed by BIM Protein Induction and BCL-XL Antagonism. Zaanan A, Okamoto K, Kawakami H, Khazaie K, Huang S, Sinicrope FA. J Biol Chem. 2015 Sep 25;290(39):23838-49. doi: 10.1074/jbc.M115.657833. Epub 2015 Aug 5. PubMed |
| Separating myoblast differentiation from muscle cell fusion using IGF-I and the p38 MAP kinase inhibitor SB202190. Gardner S, Gross SM, David LL, Klimek JE, Rotwein P. Am J Physiol Cell Physiol. 2015 Oct 1;309(7):C491-500. doi: 10.1152/ajpcell.00184.2015. Epub 2015 Aug 5. PubMed |
| Nutlin-3 sensitizes nasopharyngeal carcinoma cells to cisplatin-induced cytotoxicity. Voon YL, Ahmad M, Wong PF, Husaini R, Ng WT, Leong CO, Lane DP, Khoo AS. Oncol Rep. 2015 Oct;34(4):1692-700. doi: 10.3892/or.2015.4177. Epub 2015 Aug 5. PubMed |
| CFTR inactivation by lentiviral vector-mediated RNA interference and CRISPR-Cas9 genome editing in human airway epithelial cells. Bellec J, Bacchetta M, Losa D, Anegon I, Chanson M, Nguyen TH. Curr Gene Ther. 2015;15(5):447-59. PubMed |
| Atypical protein kinase C induces cell transformation by disrupting Hippo/Yap signaling. Archibald A, Al-Masri M, Liew-Spilger A, McCaffrey L. Mol Biol Cell. 2015 Oct 15;26(20):3578-95. doi: 10.1091/mbc.E15-05-0265. Epub 2015 Aug 12. PubMed |
| Mucosally transplanted mesenchymal stem cells stimulate intestinal healing by promoting angiogenesis. Manieri NA, Mack MR, Himmelrich MD, Worthley DL, Hanson EM, Eckmann L, Wang TC, Stappenbeck TS. J Clin Invest. 2015 Sep;125(9):3606-18. doi: 10.1172/JCI81423. Epub 2015 Aug 17. PubMed |
| Antisense-miR-21 enhances differentiation/apoptosis and reduces cancer stemness state on anaplastic thyroid cancer. Haghpanah V, Fallah P, Tavakoli R, Naderi M, Samimi H, Soleimani M, Larijani B. Tumour Biol. 2015 Aug 20. PubMed |
| Optimization of a multiplex CRISPR/Cas system for use as an antiviral therapeutic. Kennedy EM, Kornepati AV, Mefferd AL, Marshall JB, Tsai K, Bogerd HP, Cullen BR. Methods. 2015 Dec;91:82-6. doi: 10.1016/j.ymeth.2015.08.012. Epub 2015 Aug 17. PubMed |
| Retroviral Transduction of T Cells and T Cell Precursors. Simmons A, Alberola-Ila J. Methods Mol Biol. 2016;1323:99-108. doi: 10.1007/978-1-4939-2809-5_8. PubMed |
| Nuclear Localization of DNAJB6 Is Associated With Survival of Patients With Esophageal Cancer and Reduces AKT Signaling and Proliferation of Cancer Cells. Yu VZ, Wong VC, Dai W, Ko JM, Lam AK, Chan KW, Samant RS, Lung HL, Shuen WH, Law S, Chan YP, Lee NP, Tong DK, Law TT, Lee VH, Lung ML. Gastroenterology. 2015 Dec;149(7):1825-1836.e5. doi: 10.1053/j.gastro.2015.08.025. Epub 2015 Aug 22. PubMed |
| JAM-A regulates cortical dynein localization through Cdc42 to control planar spindle orientation during mitosis. Tuncay H, Brinkmann BF, Steinbacher T, Schurmann A, Gerke V, Iden S, Ebnet K. Nat Commun. 2015 Aug 26;6:8128. doi: 10.1038/ncomms9128. PubMed |
| CD45+ Cells Present Within Mesenchymal Stem Cell Populations Affect Network Formation of Blood-Derived Endothelial Outgrowth Cells. Peters EB, Christoforou N, Moore E, West JL, Truskey GA. Biores Open Access. 2015 Jan 1;4(1):75-88. doi: 10.1089/biores.2014.0029. eCollection 2015. PubMed |
| Pellino-3 promotes endotoxin tolerance and acts as a negative regulator of TLR2 and TLR4 signaling. Murphy MB, Xiong Y, Pattabiraman G, Manavalan TT, Qiu F, Medvedev AE. J Leukoc Biol. 2015 Dec;98(6):963-74. doi: 10.1189/jlb.2VMA0515-229RR. Epub 2015 Aug 26. PubMed |
| Predicting the molecular role of MEIS1 in esophageal squamous cell carcinoma. Rad A, Farshchian M, Forghanifard MM, Matin MM, Bahrami AR, Geerts D, A'rabi A, Memar B, Abbaszadegan MR. Tumour Biol. 2015 Aug 28. PubMed |
| Mutation of the BRCA1 SQ-cluster results in aberrant mitosis, reduced homologous recombination, and a compensatory increase in non-homologous end joining. Beckta JM, Dever SM, Gnawali N, Khalil A, Sule A, Golding SE, Rosenberg E, Narayanan A, Kehn-Hall K, Xu B, Povirk LF, Valerie K. Oncotarget. 2015 Sep 29;6(29):27674-87. doi: 10.18632/oncotarget.4876. PubMed |
| p53-regulated autophagy is controlled by glycolysis and determines cell fate. Duan L, Perez RE, Davaadelger B, Dedkova EN, Blatter LA, Maki CG. Oncotarget. 2015 Sep 15;6(27):23135-56. PubMed |
| Release of Vesicular Stomatitis Virus Spike Protein G-Pseudotyped Lentivirus from the Host Cell Is Impaired upon Low-Density Lipoprotein Receptor Overexpression. Otahal A, Fuchs R, Al-Allaf FA, Blaas D. J Virol. 2015 Nov;89(22):11723-6. doi: 10.1128/JVI.01869-15. Epub 2015 Sep 2. PubMed |
| Transcriptome Profiling Reveals Degree of Variability in Induced Pluripotent Stem Cell Lines: Impact for Human Disease Modeling. Schuster J, Halvardson J, Pilar Lorenzo L, Ameur A, Sobol M, Raykova D, Anneren G, Feuk L, Dahl N. Cell Reprogram. 2015 Oct;17(5):327-37. doi: 10.1089/cell.2015.0009. Epub 2015 Sep 8. PubMed |
| The Interferon-induced Transmembrane Proteins, IFITM1, IFITM2, and IFITM3 Inhibit Hepatitis C Virus Entry. Narayana SK, Helbig KJ, McCartney EM, Eyre NS, Bull RA, Eltahla A, Lloyd AR, Beard MR. J Biol Chem. 2015 Oct 23;290(43):25946-59. doi: 10.1074/jbc.M115.657346. Epub 2015 Sep 9. PubMed |
| Structural centrosome aberrations favor proliferation by abrogating microtubule-dependent tissue integrity of breast epithelial mammospheres. Schnerch D, Nigg EA. Oncogene. 2015 Sep 14. doi: 10.1038/onc.2015.332. PubMed |
| miR-128 represses L1 retrotransposition by binding directly to L1 RNA. Hamdorf M, Idica A, Zisoulis DG, Gamelin L, Martin C, Sanders KJ, Pedersen IM. Nat Struct Mol Biol. 2015 Oct;22(10):824-31. doi: 10.1038/nsmb.3090. Epub 2015 Sep 14. PubMed |
| The TRAF-interacting protein (TRAIP) is a novel E2F target with peak expression in mitosis. Chapard C, Hohl D, Huber M. Oncotarget. 2015 Aug 28;6(25):20933-45. PubMed |
| Global Transcriptome Analysis Reveals That Poly(ADP-Ribose) Polymerase 1 Regulates Gene Expression through EZH2. Martin KA, Cesaroni M, Denny MF, Lupey LN, Tempera I. Mol Cell Biol. 2015 Dec;35(23):3934-44. doi: 10.1128/MCB.00635-15. Epub 2015 Sep 14. PubMed |
MicroRNA-based conversion of human fibroblasts into striatal medium spiny neurons.
Richner M, Victor MB, Liu Y, Abernathy D, Yoo AS.
Nat Protoc. 2015 Oct;10(10):1543-55. doi: 10.1038/nprot.2015.102. Epub 2015 Sep 17.
PubMed
Associated Plasmids |
| Basal cells of the human airways acquire mesenchymal traits in idiopathic pulmonary fibrosis and in culture. Jonsdottir HR, Arason AJ, Palsson R, Franzdottir SR, Gudbjartsson T, Isaksson HJ, Gudmundsson G, Gudjonsson T, Magnusson MK. Lab Invest. 2015 Dec;95(12):1418-28. doi: 10.1038/labinvest.2015.114. Epub 2015 Sep 21. PubMed |
| Exogenous marker-engineered mesenchymal stem cells detect cancer and metastases in a simple blood assay. Liu L, Zhang SX, Aeran R, Liao W, Lu M, Polovin G, Pone EJ, Zhao W. Stem Cell Res Ther. 2015 Sep 21;6:181. doi: 10.1186/s13287-015-0151-9. PubMed |
| Routes of Ca2+ Shuttling during Ca2+ Oscillations: FOCUS ON THE ROLE OF MITOCHONDRIAL Ca2+ HANDLING AND CYTOSOLIC Ca2+ BUFFERS. Pecze L, Blum W, Schwaller B. J Biol Chem. 2015 Nov 20;290(47):28214-30. doi: 10.1074/jbc.M115.663179. Epub 2015 Sep 22. PubMed |
| OTX2 is a therapeutic target for retinoblastoma and may function as a common factor between C-MYC, CRX, and phosphorylated RB pathways. Li J, Di C, Jing J, Di Q, Nakhla J, Adamson DC. Int J Oncol. 2015 Nov;47(5):1703-10. doi: 10.3892/ijo.2015.3179. Epub 2015 Sep 23. PubMed |
Direct Induction of Trophoblast Stem Cells from Murine Fibroblasts.
Kubaczka C, Senner CE, Cierlitza M, Arauzo-Bravo MJ, Kuckenberg P, Peitz M, Hemberger M, Schorle H.
Cell Stem Cell. 2015 Sep 22. pii: S1934-5909(15)00360-4. doi: 10.1016/j.stem.2015.08.005.
PubMed
Associated Plasmids |
| LKB1 loss promotes endometrial cancer progression via CCL2-dependent macrophage recruitment. Pena CG, Nakada Y, Saatcioglu HD, Aloisio GM, Cuevas I, Zhang S, Miller DS, Lea JS, Wong KK, DeBerardinis RJ, Amelio AL, Brekken RA, Castrillon DH. J Clin Invest. 2015 Nov 2;125(11):4063-76. doi: 10.1172/JCI82152. Epub 2015 Sep 28. PubMed |
| EMMPRIN regulates tumor growth and metastasis by recruiting bone marrow-derived cells through paracrine signaling of SDF-1 and VEGF. Chen Y, Gou X, Kong DK, Wang X, Wang J, Chen Z, Huang C, Zhou J. Oncotarget. 2015 Oct 20;6(32):32575-85. doi: 10.18632/oncotarget.5331. PubMed |
| Competitive Inhibition of the Endoplasmic Reticulum Signal Peptidase by Non-cleavable Mutant Preprotein Cargos. Cui J, Chen W, Sun J, Guo H, Madley R, Xiong Y, Pan X, Wang H, Tai AW, Weiss MA, Arvan P, Liu M. J Biol Chem. 2015 Nov 20;290(47):28131-40. doi: 10.1074/jbc.M115.692350. Epub 2015 Oct 7. PubMed |
| Succination is Increased on Select Proteins in the Brainstem of the NADH dehydrogenase (ubiquinone) Fe-S protein 4 (Ndufs4) Knockout Mouse, a Model of Leigh Syndrome. Piroli GG, Manuel AM, Clapper AC, Walla MD, Baatz JE, Palmiter RD, Quintana A, Frizzell N. Mol Cell Proteomics. 2016 Feb;15(2):445-61. doi: 10.1074/mcp.M115.051516. Epub 2015 Oct 8. PubMed |
| The role of APC/C in replication stress and origin of genomic instability. Greil C, Krohs J, Schnerch D, Follo M, Felthaus J, Engelhardt M, Wasch R. Oncogene. 2015 Oct 12. doi: 10.1038/onc.2015.367. PubMed |
| MFG-E8 Is Critical for Embryonic Stem Cell-Mediated T Cell Immunomodulation. Tan Y, AlKhamees B, Jia D, Li L, Couture JF, Figeys D, Jinushi M, Wang L. Stem Cell Reports. 2015 Nov 10;5(5):741-52. doi: 10.1016/j.stemcr.2015.09.005. Epub 2015 Oct 8. PubMed |
| Transcriptional repression by the HDAC4-RelB-p52 complex regulates multiple myeloma survival and growth. Vallabhapurapu SD, Noothi SK, Pullum DA, Lawrie CH, Pallapati R, Potluri V, Kuntzen C, Khan S, Plas DR, Orlowski RZ, Chesi M, Kuehl WM, Bergsagel PL, Karin M, Vallabhapurapu S. Nat Commun. 2015 Oct 12;6:8428. doi: 10.1038/ncomms9428. PubMed |
| Reliable and inexpensive expression of large, tagged, exogenous proteins in murine bone marrow-derived macrophages using a second generation lentiviral system. Miller MR, Blystone SD. J Biol Methods. 2015;2(3):e23. PubMed |
| Targeting of BCL2 Family Proteins with ABT-199 and Homoharringtonine Reveals BCL2- and MCL1-Dependent Subgroups of Diffuse Large B-Cell Lymphoma. Klanova M, Andera L, Brazina J, Svadlenka J, Benesova S, Soukup J, Prukova D, Vejmelkova D, Jaksa R, Helman K, Vockova P, Lateckova L, Molinsky J, Maswabi BC, Alam M, Kodet R, Pytlik R, Trneny M, Klener P. Clin Cancer Res. 2015 Oct 14. PubMed |
| Knockdown of GLP-1 Receptors in Vagal Afferents Affects Normal Food Intake and Glycemia. Krieger JP, Arnold M, Pettersen KG, Lossel P, Langhans W, Lee SJ. Diabetes. 2016 Jan;65(1):34-43. doi: 10.2337/db15-0973. Epub 2015 Oct 15. PubMed |
| Targeting mitochondrial RNA polymerase in acute myeloid leukemia. Bralha FN, Liyanage SU, Hurren R, Wang X, Son MH, Fung TA, Chingcuanco FB, Tung AY, Andreazza AC, Psarianos P, Schimmer AD, Salmena L, Laposa RR. Oncotarget. 2015 Nov 10;6(35):37216-28. doi: 10.18632/oncotarget.6129. PubMed |
| Interferon Kappa Inhibits Human Papillomavirus 31 Transcription by Inducing Sp100 Proteins. Habiger C, Jager G, Walter M, Iftner T, Stubenrauch F. J Virol. 2015 Oct 21;90(2):694-704. doi: 10.1128/JVI.02137-15. PubMed |
| TrkA is amplified in malignant melanoma patients and induces an anti-proliferative response in cell lines. Pasini L, Re A, Tebaldi T, Ricci G, Boi S, Adami V, Barbareschi M, Quattrone A. BMC Cancer. 2015 Oct 24;15:777. doi: 10.1186/s12885-015-1791-y. PubMed |
Highly specific epigenome editing by CRISPR-Cas9 repressors for silencing of distal regulatory elements.
Thakore PI, D'Ippolito AM, Song L, Safi A, Shivakumar NK, Kabadi AM, Reddy TE, Crawford GE, Gersbach CA.
Nat Methods. 2015 Dec;12(12):1143-9. doi: 10.1038/nmeth.3630. Epub 2015 Oct 26.
PubMed
Associated Plasmids |
| Skeletal Muscle Phospholipid Metabolism Regulates Insulin Sensitivity and Contractile Function. Funai K, Lodhi IJ, Spears LD, Yin L, Song H, Klein S, Semenkovich CF. Diabetes. 2016 Feb;65(2):358-70. doi: 10.2337/db15-0659. Epub 2015 Oct 28. PubMed |
| Identification of short-form RON as a novel intrinsic resistance mechanism for anti-MET therapy in MET-positive gastric cancer. Wu Z, Zhang Z, Ge X, Lin Y, Dai C, Chang J, Liu X, Geng R, Wang C, Chen H, Sun M, Guo W, Li J. Oncotarget. 2015 Dec 1;6(38):40519-34. doi: 10.18632/oncotarget.5816. PubMed |
| Combinatorial BTK and MALT1 inhibition augments killing of CD79 mutant diffuse large B cell lymphoma. Nagel D, Bognar M, Eitelhuber AC, Kutzner K, Vincendeau M, Krappmann D. Oncotarget. 2015 Dec 8;6(39):42232-42. doi: 10.18632/oncotarget.6273. PubMed |
| Differentiation of human ESCs to retinal ganglion cells using a CRISPR engineered reporter cell line. Sluch VM, Davis CH, Ranganathan V, Kerr JM, Krick K, Martin R, Berlinicke CA, Marsh-Armstrong N, Diamond JS, Mao HQ, Zack DJ. Sci Rep. 2015 Nov 13;5:16595. doi: 10.1038/srep16595. PubMed |
| The leukodystrophy protein FAM126A (hyccin) regulates PtdIns(4)P synthesis at the plasma membrane. Baskin JM, Wu X, Christiano R, Oh MS, Schauder CM, Gazzerro E, Messa M, Baldassari S, Assereto S, Biancheri R, Zara F, Minetti C, Raimondi A, Simons M, Walther TC, Reinisch KM, De Camilli P. Nat Cell Biol. 2016 Jan;18(1):132-8. doi: 10.1038/ncb3271. Epub 2015 Nov 16. PubMed |
| Fat4 suppression induces Yap translocation accounting for the promoted proliferation and migration of gastric cancer cells. Ma L, Cui J, Xi H, Bian S, Wei B, Chen L. Cancer Biol Ther. 2016;17(1):36-47. doi: 10.1080/15384047.2015.1108488. PubMed |
| ETS family transcriptional regulators drive chromatin dynamics and malignancy in squamous cell carcinomas. Yang H, Schramek D, Adam RC, Keyes BE, Wang P, Zheng D, Fuchs E. Elife. 2015 Nov 21;4. pii: e10870. doi: 10.7554/eLife.10870. PubMed |
| Targeting p300 Addiction in CBP-Deficient Cancers Causes Synthetic Lethality by Apoptotic Cell Death due to Abrogation of MYC Expression. Ogiwara H, Sasaki M, Mitachi T, Oike T, Higuchi S, Tominaga Y, Kohno T. Cancer Discov. 2016 Apr;6(4):430-45. doi: 10.1158/2159-8290.CD-15-0754. Epub 2015 Nov 24. PubMed |
| Non-epigenetic function of HDAC8 in regulating breast cancer stem cells by maintaining Notch1 protein stability. Chao MW, Chu PC, Chuang HC, Shen FH, Chou CC, Hsu EC, Himmel LE, Huang HL, Tu HJ, Kulp SK, Teng CM, Chen CS. Oncotarget. 2016 Jan 12;7(2):1796-807. doi: 10.18632/oncotarget.6427. PubMed |
| PTEN deficiency reprogrammes human neural stem cells towards a glioblastoma stem cell-like phenotype. Duan S, Yuan G, Liu X, Ren R, Li J, Zhang W, Wu J, Xu X, Fu L, Li Y, Yang J, Zhang W, Bai R, Yi F, Suzuki K, Gao H, Esteban CR, Zhang C, Izpisua Belmonte JC, Chen Z, Wang X, Jiang T, Qu J, Tang F, Liu GH. Nat Commun. 2015 Dec 3;6:10068. doi: 10.1038/ncomms10068. PubMed |
| alpha-synuclein interacts with SOD1 and promotes its oligomerization. Helferich AM, Ruf WP, Grozdanov V, Freischmidt A, Feiler MS, Zondler L, Ludolph AC, McLean PJ, Weishaupt JH, Danzer KM. Mol Neurodegener. 2015 Dec 8;10:66. doi: 10.1186/s13024-015-0062-3. PubMed |
| The Notch and Wnt pathways regulate stemness and differentiation in human fallopian tube organoids. Kessler M, Hoffmann K, Brinkmann V, Thieck O, Jackisch S, Toelle B, Berger H, Mollenkopf HJ, Mangler M, Sehouli J, Fotopoulou C, Meyer TF. Nat Commun. 2015 Dec 8;6:8989. doi: 10.1038/ncomms9989. PubMed |
| Deregulated KLF4 Expression in Myeloid Leukemias Alters Cell Proliferation and Differentiation through MicroRNA and Gene Targets. Morris VA, Cummings CL, Korb B, Boaglio S, Oehler VG. Mol Cell Biol. 2015 Dec 7;36(4):559-73. doi: 10.1128/MCB.00712-15. PubMed |
| A Common CCK-B Receptor Intronic Variant in Pancreatic Adenocarcinoma in a Hungarian Cohort. Balazs A, Nemeth BC, Ordog B, Hegyi E, Hritz I, Czako L, Czimmer J, Godi S, Csiszko A, Rakonczay Z Jr, Parniczky A, Izbeki F, Halasz A, Kahan Z, Hegyi P, Sahin-Toth M. Pancreas. 2016 Apr;45(4):541-5. doi: 10.1097/MPA.0000000000000539. PubMed |
| Characterization of a Novel Human-Specific STING Agonist that Elicits Antiviral Activity Against Emerging Alphaviruses. Sali TM, Pryke KM, Abraham J, Liu A, Archer I, Broeckel R, Staverosky JA, Smith JL, Al-Shammari A, Amsler L, Sheridan K, Nilsen A, Streblow DN, DeFilippis VR. PLoS Pathog. 2015 Dec 8;11(12):e1005324. doi: 10.1371/journal.ppat.1005324. eCollection 2015 Dec. PubMed |
| Transduction of an immortalized olfactory ensheathing glia cell line with the green fluorescent protein (GFP) gene: Evaluation of its neuroregenerative capacity as a proof of concept. Plaza N, Simon D, Sierra J, Moreno-Flores MT. Neurosci Lett. 2016 Jan 26;612:25-31. doi: 10.1016/j.neulet.2015.12.001. Epub 2015 Dec 3. PubMed |
| C/EBPgamma is a critical regulator of cellular stress response networks through heterodimerization with ATF4. Huggins CJ, Mayekar MK, Martin N, Saylor KL, Gonit M, Jailwala P, Kasoji M, Haines DC, Quinones OA, Johnson PF. Mol Cell Biol. 2015 Dec 14. pii: MCB.00911-15. PubMed |
| A Gene Expression Signature Associated with Overall Survival in Patients with Hepatocellular Carcinoma Suggests a New Treatment Strategy. Gillet JP, Andersen JB, Madigan JP, Varma S, Bagni RK, Powell K, Burgan WE, Wu CP, Calcagno AM, Ambudkar SV, Thorgeirsson SS, Gottesman MM. Mol Pharmacol. 2016 Feb;89(2):263-72. doi: 10.1124/mol.115.101360. Epub 2015 Dec 14. PubMed |
| Specific induction of endogenous viral restriction factors using CRISPR/Cas-derived transcriptional activators. Bogerd HP, Kornepati AV, Marshall JB, Kennedy EM, Cullen BR. Proc Natl Acad Sci U S A. 2015 Dec 29;112(52):E7249-56. doi: 10.1073/pnas.1516305112. Epub 2015 Dec 14. PubMed |
| TBX3 Knockdown Decreases Reprogramming Efficiency of Human Cells. Klingenstein M, Raab S, Achberger K, Kleger A, Liebau S, Linta L. Stem Cells Int. 2016;2016:6759343. doi: 10.1155/2016/6759343. Epub 2015 Nov 30. PubMed |
| Upregulation of EMMPRIN (OX47) in Rat Dorsal Root Ganglion Contributes to the Development of Mechanical Allodynia after Nerve Injury. Wang Q, Sun Y, Ren Y, Gao Y, Tian L, Liu Y, Pu Y, Gou X, Chen Y, Lu Y. Neural Plast. 2015;2015:249756. doi: 10.1155/2015/249756. Epub 2015 Nov 30. PubMed |
| Manipulation of the N-terminal sequence of the Borna disease virus X protein improves its mitochondrial targeting and neuroprotective potential. Ferre CA, Davezac N, Thouard A, Peyrin JM, Belenguer P, Miquel MC, Gonzalez-Dunia D, Szelechowski M. FASEB J. 2015 Dec 23. pii: fj.15-279620. PubMed |
| Genome-Wide Transcriptional Regulation Mediated by Biochemically Distinct SWI/SNF Complexes. Raab JR, Resnick S, Magnuson T. PLoS Genet. 2015 Dec 30;11(12):e1005748. doi: 10.1371/journal.pgen.1005748. eCollection 2015 Dec. PubMed |
| PARK2 enhancement is able to compensate mitophagy alterations found in sporadic Alzheimer's disease. Martin-Maestro P, Gargini R, Perry G, Avila J, Garcia-Escudero V. Hum Mol Genet. 2016 Feb 15;25(4):792-806. doi: 10.1093/hmg/ddv616. Epub 2015 Dec 31. PubMed |
| The Polymerase Activity of Mammalian DNA Pol zeta Is Specifically Required for Cell and Embryonic Viability. Lange SS, Tomida J, Boulware KS, Bhetawal S, Wood RD. PLoS Genet. 2016 Jan 4;12(1):e1005759. doi: 10.1371/journal.pgen.1005759. eCollection 2016 Jan. PubMed |
| CRISPR Technology for Genome Activation and Repression in Mammalian Cells. Du D, Qi LS. Cold Spring Harb Protoc. 2016 Jan 4;2016(1):pdb.prot090175. doi: 10.1101/pdb.prot090175. PubMed |
| A Conserved Interaction between a C-Terminal Motif in Norovirus VPg and the HEAT-1 Domain of eIF4G Is Essential for Translation Initiation. Leen EN, Sorgeloos F, Correia S, Chaudhry Y, Cannac F, Pastore C, Xu Y, Graham SC, Matthews SJ, Goodfellow IG, Curry S. PLoS Pathog. 2016 Jan 6;12(1):e1005379. doi: 10.1371/journal.ppat.1005379. eCollection 2016 Jan. PubMed |
| Inhibition of Canonical NF-kappaB Signaling by a Small Molecule Targeting NEMO-Ubiquitin Interaction. Vincendeau M, Hadian K, Messias AC, Brenke JK, Halander J, Griesbach R, Greczmiel U, Bertossi A, Stehle R, Nagel D, Demski K, Velvarska H, Niessing D, Geerlof A, Sattler M, Krappmann D. Sci Rep. 2016 Jan 7;6:18934. doi: 10.1038/srep18934. PubMed |
| Epithelial but not stromal expression of collagen alpha-1(III) is a diagnostic and prognostic indicator of colorectal carcinoma. Wang XQ, Tang ZX, Yu D, Cui SJ, Jiang YH, Zhang Q, Wang J, Yang PY, Liu F. Oncotarget. 2016 Feb 23;7(8):8823-38. doi: 10.18632/oncotarget.6815. PubMed |
| Research Resource: Genetic Labeling of Human Islet Alpha Cells. Pauerstein PT, Park KM, Peiris HS, Wang J, Kim SK. Mol Endocrinol. 2016 Feb;30(2):248-53. doi: 10.1210/me.2015-1220. Epub 2016 Jan 8. PubMed |
| C9orf72 promoter hypermethylation is reduced while hydroxymethylation is acquired during reprogramming of ALS patient cells. Esanov R, Belle KC, van Blitterswijk M, Belzil VV, Rademakers R, Dickson DW, Petrucelli L, Boylan KB, Dykxhoorn DM, Wuu J, Benatar M, Wahlestedt C, Zeier Z. Exp Neurol. 2016 Mar;277:171-7. doi: 10.1016/j.expneurol.2015.12.022. Epub 2015 Dec 31. PubMed |
| Haploinsufficiency of BAZ1B contributes to Williams syndrome through transcriptional dysregulation of neurodevelopmental pathways. Lalli MA, Jang J, Park JC, Wang Y, Guzman E, Zhou H, Audouard M, Bridges D, Tovar KR, Papuc SM, Tutulan-Cunita AC, Huang Y, Budisteanu M, Arghir A, Kosik KS. Hum Mol Genet. 2016 Jan 10. pii: ddw010. PubMed |
| Epithelial-to-Mesenchymal Transition of RPE Cells In Vitro Confers Increased beta1,6-N-Glycosylation and Increased Susceptibility to Galectin-3 Binding. Priglinger CS, Obermann J, Szober CM, Merl-Pham J, Ohmayer U, Behler J, Gruhn F, Kreutzer TC, Wertheimer C, Geerlof A, Priglinger SG, Hauck SM. PLoS One. 2016 Jan 13;11(1):e0146887. doi: 10.1371/journal.pone.0146887. eCollection 2016. PubMed |
| Disease causing mutations in inverted formin 2 regulate its binding to G-actin, F-actin capping protein (CapZ alpha-1) and profilin 2. Rollason R, Wherlock M, Heath JA, Heesom KJ, Saleem MA, Welsh GI. Biosci Rep. 2016 Jan 13;36(1):e00302. doi: 10.1042/BSR20150252. PubMed |
| Human pluripotent stem cell culture density modulates YAP signaling. Hsiao C, Lampe M, Nillasithanukroh S, Han W, Lian X, Palecek SP. Biotechnol J. 2016 Jan 14. doi: 10.1002/biot.201500374. PubMed |
| Oncogenic CARMA1 couples NF-kappaB and beta-catenin signaling in diffuse large B-cell lymphomas. Bognar MK, Vincendeau M, Erdmann T, Seeholzer T, Grau M, Linnemann JR, Ruland J, Scheel CH, Lenz P, Ott G, Lenz G, Hauck SM, Krappmann D. Oncogene. 2016 Jan 18. doi: 10.1038/onc.2015.493. PubMed |
| Mitofusin 2 maintains haematopoietic stem cells with extensive lymphoid potential. Luchsinger LL, de Almeida MJ, Corrigan DJ, Mumau M, Snoeck HW. Nature. 2016 Jan 28;529(7587):528-31. doi: 10.1038/nature16500. Epub 2016 Jan 20. PubMed |
| Live imaging of microtubule dynamics in organotypic hippocampal slice cultures. Schatzle P, Kapitein LC, Hoogenraad CC. Methods Cell Biol. 2016;131:107-26. doi: 10.1016/bs.mcb.2015.06.006. Epub 2015 Sep 3. PubMed |
| Induced Pluripotent Stem Cells of Microtus levis x Microtus arvalis Vole Hybrids: Conditions Necessary for Their Generation and Self-Renewal. Grigor'eva EV, Shevchenko AI, Medvedev SP, Mazurok NA, Zhelezova AI, Zakian SM. Acta Naturae. 2015 Oct-Dec;7(4):56-69. PubMed |
| TFEB and TFE3 are novel components of the integrated stress response. Martina JA, Diab HI, Brady OA, Puertollano R. EMBO J. 2016 Mar 1;35(5):479-95. doi: 10.15252/embj.201593428. Epub 2016 Jan 25. PubMed |
| Mitochondrial genome variations and functional characterization in Han Chinese families with schizophrenia. Bi R, Tang J, Zhang W, Li X, Chen SY, Yu D, Chen X, Yao YG. Schizophr Res. 2016 Jan 25. pii: S0920-9964(16)30011-1. doi: 10.1016/j.schres.2016.01.011. PubMed |
| Staufen1 Regulates Multiple Alternative Splicing Events either Positively or Negatively in DM1 Indicating Its Role as a Disease Modifier. Bondy-Chorney E, Crawford Parks TE, Ravel-Chapuis A, Klinck R, Rocheleau L, Pelchat M, Chabot B, Jasmin BJ, Cote J. PLoS Genet. 2016 Jan 29;12(1):e1005827. doi: 10.1371/journal.pgen.1005827. eCollection 2016 Jan. PubMed |
| T-cell libraries allow simple parallel generation of multiple peptide-specific human T-cell clones. Theaker SM, Rius C, Greenshields-Watson A, Lloyd A, Trimby A, Fuller A, Miles JJ, Cole DK, Peakman M, Sewell AK, Dolton G. J Immunol Methods. 2016 Jan 27. pii: S0022-1759(16)30014-X. doi: 10.1016/j.jim.2016.01.014. PubMed |
| Agonist-induced activation of histamine H3 receptor signals to extracellular signal-regulated kinases 1 and 2 through PKC-, PLD-, and EGFR-dependent mechanisms. Lai X, Ye L, Liao Y, Jin L, Ma Q, Lu B, Sun Y, Shi Y, Zhou N. J Neurochem. 2016 Apr;137(2):200-15. doi: 10.1111/jnc.13559. Epub 2016 Mar 10. PubMed |
| Opposing Roles of JNK and p38 in Lymphangiogenesis in Melanoma. Puujalka E, Heinz M, Hoesel B, Friedl P, Schweighofer B, Wenzina J, Pirker C, Schmid JA, Loewe R, Wagner EF, Berger W, Petzelbauer P. J Invest Dermatol. 2016 May;136(5):967-77. doi: 10.1016/j.jid.2016.01.020. Epub 2016 Jan 30. PubMed |
| WNT/beta-catenin signaling mediates human neural crest induction via a pre-neural border intermediate. Leung AW, Murdoch B, Salem AF, Prasad MS, Gomez GA, Garcia-Castro MI. Development. 2016 Feb 1;143(3):398-410. doi: 10.1242/dev.130849. PubMed |
| Regulation of Nuclear Receptor Nur77 by miR-124. Tenga A, Beard JA, Takwi A, Wang YM, Chen T. PLoS One. 2016 Feb 3;11(2):e0148433. doi: 10.1371/journal.pone.0148433. eCollection 2016. PubMed |
| MeCP2 SUMOylation rescues Mecp2-mutant-induced behavioural deficits in a mouse model of Rett syndrome. Tai DJ, Liu YC, Hsu WL, Ma YL, Cheng SJ, Liu SY, Lee EH. Nat Commun. 2016 Feb 4;7:10552. doi: 10.1038/ncomms10552. PubMed |
| Microtubules Inhibit E-Cadherin Adhesive Activity by Maintaining Phosphorylated p120-Catenin in a Colon Carcinoma Cell Model. Maiden SL, Petrova YI, Gumbiner BM. PLoS One. 2016 Feb 4;11(2):e0148574. doi: 10.1371/journal.pone.0148574. eCollection 2016. PubMed |
| Lysophosphatidic acid activates Arf6 to promote the mesenchymal malignancy of renal cancer. Hashimoto S, Mikami S, Sugino H, Yoshikawa A, Hashimoto A, Onodera Y, Furukawa S, Handa H, Oikawa T, Okada Y, Oya M, Sabe H. Nat Commun. 2016 Feb 8;7:10656. doi: 10.1038/ncomms10656. PubMed |
| Feedback activation of neurofibromin terminates growth factor-induced Ras activation. Hennig A, Markwart R, Wolff K, Schubert K, Cui Y, Prior IA, Esparza-Franco MA, Ladds G, Rubio I. Cell Commun Signal. 2016 Feb 9;14:5. doi: 10.1186/s12964-016-0128-z. PubMed |
| The Endoplasmic Reticulum Chaperone Calnexin Is a NADPH Oxidase NOX4 Interacting Protein. Prior KK, Wittig I, Leisegang MS, Groenendyk J, Weissmann N, Michalak M, Jansen-Durr P, Shah AM, Brandes RP. J Biol Chem. 2016 Mar 25;291(13):7045-59. doi: 10.1074/jbc.M115.710772. Epub 2016 Feb 9. PubMed |
| beta-catenin-independent WNT signaling and Ki67 in contrast to the estrogen receptor status are prognostic and associated with poor prognosis in breast cancer liver metastases. Bleckmann A, Conradi LC, Menck K, Schmick NA, Schubert A, Rietkotter E, Arackal J, Middel P, Schambony A, Liersch T, Homayounfar K, Beissbarth T, Klemm F, Binder C, Pukrop T. Clin Exp Metastasis. 2016 Apr;33(4):309-23. doi: 10.1007/s10585-016-9780-3. Epub 2016 Feb 9. PubMed |
| The Sigma-2 Receptor and Progesterone Receptor Membrane Component 1 are Different Binding Sites Derived From Independent Genes. Chu UB, Mavlyutov TA, Chu ML, Yang H, Schulman A, Mesangeau C, McCurdy CR, Guo LW, Ruoho AE. EBioMedicine. 2015 Oct 19;2(11):1806-13. doi: 10.1016/j.ebiom.2015.10.017. eCollection 2015 Nov. PubMed |
| GemC1 controls multiciliogenesis in the airway epithelium. Arbi M, Pefani DE, Kyrousi C, Lalioti ME, Kalogeropoulou A, Papanastasiou AD, Taraviras S, Lygerou Z. EMBO Rep. 2016 Mar;17(3):400-13. doi: 10.15252/embr.201540882. Epub 2016 Feb 4. PubMed |
| Progesterone receptor (PR) polyproline domain (PPD) mediates inhibition of epidermal growth factor receptor (EGFR) signaling in non-small cell lung cancer cells. Kawprasertsri S, Pietras RJ, Marquez-Garban DC, Boonyaratanakornkit V. Cancer Lett. 2016 May 1;374(2):279-91. doi: 10.1016/j.canlet.2016.02.014. Epub 2016 Feb 15. PubMed |
NBR1 enables autophagy-dependent focal adhesion turnover.
Kenific CM, Stehbens SJ, Goldsmith J, Leidal AM, Faure N, Ye J, Wittmann T, Debnath J.
J Cell Biol. 2016 Feb 29;212(5):577-590. Epub 2016 Feb 22.
PubMed
Associated Plasmids |
| Integrin-linked kinase as a novel molecular switch of the IL-6-NF-kappaB signaling loop in breast cancer. Hsu EC, Kulp SK, Huang HL, Tu HJ, Chao MW, Tseng YC, Yang MC, Salunke SB, Sullivan NJ, Chen WC, Zhang J, Teng CM, Fu WM, Sun D, Wicha MS, Shapiro CL, Chen CS. Carcinogenesis. 2016 Apr;37(4):430-42. doi: 10.1093/carcin/bgw020. Epub 2016 Feb 19. PubMed |
| Specifically modified Env immunogens activate B-cell precursors of broadly neutralizing HIV-1 antibodies in transgenic mice. McGuire AT, Gray MD, Dosenovic P, Gitlin AD, Freund NT, Petersen J, Correnti C, Johnsen W, Kegel R, Stuart AB, Glenn J, Seaman MS, Schief WR, Strong RK, Nussenzweig MC, Stamatatos L. Nat Commun. 2016 Feb 24;7:10618. doi: 10.1038/ncomms10618. PubMed |
| GATA3-dependent cellular reprogramming requires activation-domain dependent recruitment of a chromatin remodeler. Takaku M, Grimm SA, Shimbo T, Perera L, Menafra R, Stunnenberg HG, Archer TK, Machida S, Kurumizaka H, Wade PA. Genome Biol. 2016 Feb 27;17:36. doi: 10.1186/s13059-016-0897-0. PubMed |
| Radiosensitization by PARP Inhibition in DNA Repair Proficient and Deficient Tumor Cells: Proliferative Recovery in Senescent Cells. Alotaibi M, Sharma K, Saleh T, Povirk LF, Hendrickson EA, Gewirtz DA. Radiat Res. 2016 Mar;185(3):229-45. doi: 10.1667/RR14202.1. Epub 2016 Mar 2. PubMed |
| Neuronal Orphan G-Protein Coupled Receptor Proteins Mediate Plasmalogens-Induced Activation of ERK and Akt Signaling. Hossain MS, Mineno K, Katafuchi T. PLoS One. 2016 Mar 2;11(3):e0150846. doi: 10.1371/journal.pone.0150846. eCollection 2016. PubMed |
| LKB1 inhibits the proliferation of gastric cancer cells by suppressing the nuclear translocation of Yap and beta-catenin. Ma LG, Bian SB, Cui JX, Xi HQ, Zhang KC, Qin HZ, Zhu XM, Chen L. Int J Mol Med. 2016 Apr;37(4):1039-48. doi: 10.3892/ijmm.2016.2494. Epub 2016 Feb 19. PubMed |
| Editing of mouse and human immunoglobulin genes by CRISPR-Cas9 system. Cheong TC, Compagno M, Chiarle R. Nat Commun. 2016 Mar 9;7:10934. doi: 10.1038/ncomms10934. PubMed |
| Stable and Efficient Genetic Modification of Cells in the Adult Mouse V-SVZ for the Analysis of Neural Stem Cell Autonomous and Non-autonomous Effects. Porlan E, Marti-Prado B, Consiglio A, Farinas I. J Vis Exp. 2016 Feb 17;(108). doi: 10.3791/53282. PubMed |
| An integrin beta4-EGFR unit promotes hepatocellular carcinoma lung metastases by enhancing anchorage independence through activation of FAK-AKT pathway. Leng C, Zhang ZG, Chen WX, Luo HP, Song J, Dong W, Zhu XR, Chen XP, Liang HF, Zhang BX. Cancer Lett. 2016 Jun 28;376(1):188-96. doi: 10.1016/j.canlet.2016.03.023. Epub 2016 Mar 17. PubMed |
| Ultrahigh-throughput Generation and Characterization of Cellular Aggregates in Laser-ablated Microwells of Poly(dimethylsiloxane). Albritton JL, Roybal JD, Paulsen SJ, Calafat N, Flores-Zaher JA, Farach-Carson MC, Gibbons DL, Miller JS. RSC Adv. 2016 Jan 1;6(11):8980-8991. Epub 2016 Jan 12. PubMed |
| Hypoxia-regulated gene expression explains differences between melanoma cell line-derived xenografts and patient-derived xenografts. Bhadury J, Einarsdottir BO, Podraza A, Bagge RO, Stierner U, Ny L, Davila Lopez M, Nilsson JA. Oncotarget. 2016 Apr 26;7(17):23801-11. doi: 10.18632/oncotarget.8181. PubMed |
| Enhancing DPYSL3 gene expression via a promoter-targeted small activating RNA approach suppresses cancer cell motility and metastasis. Li C, Jiang W, Hu Q, Li LC, Dong L, Chen R, Zhang Y, Tang Y, Thrasher JB, Liu CB, Li B. Oncotarget. 2016 Mar 23. doi: 10.18632/oncotarget.8290. PubMed |
| PCGF2 negatively regulates arsenic trioxide-induced PML-RARA protein degradation via UBE2I inhibition in NB4 cells. Jo S, Lee YL, Kim S, Lee H, Chung H. Biochim Biophys Acta. 2016 Jul;1863(7 Pt A):1499-509. doi: 10.1016/j.bbamcr.2016.03.019. Epub 2016 Mar 24. PubMed |
| P53- and mevalonate pathway-driven malignancies require Arf6 for metastasis and drug resistance. Hashimoto A, Oikawa T, Hashimoto S, Sugino H, Yoshikawa A, Otsuka Y, Handa H, Onodera Y, Nam JM, Oneyama C, Okada M, Fukuda M, Sabe H. J Cell Biol. 2016 Apr 11;213(1):81-95. doi: 10.1083/jcb.201510002. Epub 2016 Apr 4. PubMed |
| Complex Regulation Pattern of IRF3 Activation Revealed by a Novel Dimerization Reporter System. Wang Z, Ji J, Peng D, Ma F, Cheng G, Qin FX. J Immunol. 2016 May 15;196(10):4322-30. doi: 10.4049/jimmunol.1502458. Epub 2016 Apr 4. PubMed |
| Circadian factors BMAL1 and RORalpha control HIF-1alpha transcriptional activity in nucleus pulposus cells: implications in maintenance of intervertebral disc health. Suyama K, Silagi ES, Choi H, Sakabe K, Mochida J, Shapiro IM, Risbud MV. Oncotarget. 2016 Mar 31. doi: 10.18632/oncotarget.8521. PubMed |
| Large-scale production of megakaryocytes from human pluripotent stem cells by chemically defined forward programming. Moreau T, Evans AL, Vasquez L, Tijssen MR, Yan Y, Trotter MW, Howard D, Colzani M, Arumugam M, Wu WH, Dalby A, Lampela R, Bouet G, Hobbs CM, Pask DC, Payne H, Ponomaryov T, Brill A, Soranzo N, Ouwehand WH, Pedersen RA, Ghevaert C. Nat Commun. 2016 Apr 7;7:11208. doi: 10.1038/ncomms11208. PubMed |
| Development of Third-generation Cocal Envelope Producer Cell Lines for Robust Lentiviral Gene Transfer into Hematopoietic Stem Cells and T-cells. Humbert O, Gisch DW, Wohlfahrt ME, Adams AB, Greenberg PD, Schmitt TM, Trobridge GD, Kiem HP. Mol Ther. 2016 May 24. doi: 10.1038/mt.2016.70. PubMed |
| Infection of epithelial cells with Chlamydia trachomatis inhibits TNF-induced apoptosis at the level of receptor internalisation while leaving non-apoptotic TNF-signalling intact. Kontchou CW, Tzivelekidis T, Gentle IE, Hacker G. Cell Microbiol. 2016 Apr 8. doi: 10.1111/cmi.12598. PubMed |
| Thyroid follicle development requires Smad1/5- and endothelial cell-dependent basement membrane assembly. Villacorte M, Delmarcelle AS, Lernoux M, Bouquet M, Lemoine P, Bolsee J, Umans L, de Sousa Lopes SC, Van Der Smissen P, Sasaki T, Bommer G, Henriet P, Refetoff S, Lemaigre FP, Zwijsen A, Courtoy PJ, Pierreux CE. Development. 2016 Jun 1;143(11):1958-70. doi: 10.1242/dev.134171. Epub 2016 Apr 11. PubMed |
| ExtraPEG: A Polyethylene Glycol-Based Method for Enrichment of Extracellular Vesicles. Rider MA, Hurwitz SN, Meckes DG Jr. Sci Rep. 2016 Apr 12;6:23978. doi: 10.1038/srep23978. PubMed |
| Development of Rabies Virus-Like Particles for Vaccine Applications: Production, Characterization, and Protection Studies. Fontana D, Etcheverrigaray M, Kratje R, Prieto C. Methods Mol Biol. 2016;1403:155-66. doi: 10.1007/978-1-4939-3387-7_7. PubMed |
| PPARgamma Is Activated during Congenital Cytomegalovirus Infection and Inhibits Neuronogenesis from Human Neural Stem Cells. Rolland M, Li X, Sellier Y, Martin H, Perez-Berezo T, Rauwel B, Benchoua A, Bessieres B, Aziza J, Cenac N, Luo M, Casper C, Peschanski M, Gonzalez-Dunia D, Leruez-Ville M, Davrinche C, Chavanas S. PLoS Pathog. 2016 Apr 14;12(4):e1005547. doi: 10.1371/journal.ppat.1005547. eCollection 2016 Apr. PubMed |
| Per2 induction limits lymphoid-biased haematopoietic stem cells and lymphopoiesis in the context of DNA damage and ageing. Wang J, Morita Y, Han B, Niemann S, Loffler B, Rudolph KL. Nat Cell Biol. 2016 May;18(5):480-90. doi: 10.1038/ncb3342. Epub 2016 Apr 18. PubMed |
| CD99 isoforms regulate CD1a expression in human monocyte-derived DCs through ATF-2/CREB-1 phosphorylation. Mahiddine K, Mallavialle A, Bziouech H, Larbret F, Bernard A, Bernard G. Eur J Immunol. 2016 Jun;46(6):1460-71. doi: 10.1002/eji.201546143. Epub 2016 May 6. PubMed |
| The Herpes Simplex Virus Virion Host Shutoff Protein Enhances Translation of Viral True Late mRNAs Independently of Suppressing Protein Kinase R and Stress Granule Formation. Dauber B, Poon D, Dos Santos T, Duguay BA, Mehta N, Saffran HA, Smiley JR. J Virol. 2016 Jun 10;90(13):6049-57. doi: 10.1128/JVI.03180-15. Print 2016 Jul 1. PubMed |
| Enhanced direct conversion of fibroblasts into hepatocyte-like cells by Kdm2b. Zakikhan K, Pournasr B, Nassiri-Asl M, Baharvand H. Biochem Biophys Res Commun. 2016 May 20;474(1):97-103. doi: 10.1016/j.bbrc.2016.04.076. Epub 2016 Apr 19. PubMed |
| In Vitro Differentiation of Mouse Granulocytes. Reinhart R, Wicki S, Kaufmann T. Methods Mol Biol. 2016;1419:95-107. doi: 10.1007/978-1-4939-3581-9_8. PubMed |
| A convenient and effective strategy for the enrichment of tumor-initiating cell properties in prostate cancer cells. Zhang Y, Huang Y, Jin Z, Li X, Li B, Xu P, Huang P, Liu C. Tumour Biol. 2016 Apr 25. PubMed |
| The orphan nuclear receptor NR4A2 is part of a p53-microRNA-34 network. Beard JA, Tenga A, Hills J, Hoyer JD, Cherian MT, Wang YD, Chen T. Sci Rep. 2016 Apr 28;6:25108. doi: 10.1038/srep25108. PubMed |
Methods for Efficient Elimination of Mitochondrial DNA from Cultured Cells.
Spadafora D, Kozhukhar N, Chouljenko VN, Kousoulas KG, Alexeyev MF.
PLoS One. 2016 May 2;11(5):e0154684. doi: 10.1371/journal.pone.0154684. eCollection 2016.
PubMed
Associated Plasmids |
| The mitochondrial calcium uniporter regulates breast cancer progression via HIF-1alpha. Tosatto A, Sommaggio R, Kummerow C, Bentham RB, Blacker TS, Berecz T, Duchen MR, Rosato A, Bogeski I, Szabadkai G, Rizzuto R, Mammucari C. EMBO Mol Med. 2016 May 2;8(5):569-85. doi: 10.15252/emmm.201606255. PubMed |
TET2 Regulates Mast Cell Differentiation and Proliferation through Catalytic and Non-catalytic Activities.
Montagner S, Leoni C, Emming S, Della Chiara G, Balestrieri C, Barozzi I, Piccolo V, Togher S, Ko M, Rao A, Natoli G, Monticelli S.
Cell Rep. 2016 May 17;15(7):1566-79. doi: 10.1016/j.celrep.2016.04.044. Epub 2016 May 5.
PubMed
Associated Plasmids |
| The three Type 2A protein phosphatases, PP2Ac, PP4c and PP6c, are differentially regulated by Alpha4. LeNoue-Newton ML, Wadzinski BE, Spiller BW. Biochem Biophys Res Commun. 2016 Jun 17;475(1):64-9. doi: 10.1016/j.bbrc.2016.05.036. Epub 2016 May 8. PubMed |
| TFEB and TFE3 cooperate in the regulation of the innate immune response in activated macrophages. Pastore N, Brady OA, Diab HI, Martina JA, Sun L, Huynh T, Lim JA, Zare H, Raben N, Ballabio A, Puertollano R. Autophagy. 2016 May 12:1-19. PubMed |
| Targeting by AutophaGy proteins (TAG): Targeting of IFNG-inducible GTPases to membranes by the LC3 conjugation system of autophagy. Park S, Choi J, Biering SB, Dominici E, Williams LE, Hwang S. Autophagy. 2016 Jul 2;12(7):1153-67. doi: 10.1080/15548627.2016.1178447. Epub 2016 May 12. PubMed |
| The antitumor toxin CD437 is a direct inhibitor of DNA polymerase alpha. Han T, Goralski M, Capota E, Padrick SB, Kim J, Xie Y, Nijhawan D. Nat Chem Biol. 2016 Jul;12(7):511-5. doi: 10.1038/nchembio.2082. Epub 2016 May 16. PubMed |
| Fibroblast growth factor receptor 4 (FGFR4) and fibroblast growth factor 19 (FGF19) autocrine enhance breast cancer cells survival. Tiong KH, Tan BS, Choo HL, Chung FF, Hii LW, Tan SH, Khor NT, Wong SF, See SJ, Tan YF, Rosli R, Cheong SK, Leong CO. Oncotarget. 2016 Sep 6;7(36):57633-57650. doi: 10.18632/oncotarget.9328. PubMed |
| ISPD produces CDP-ribitol used by FKTN and FKRP to transfer ribitol phosphate onto alpha-dystroglycan. Gerin I, Ury B, Breloy I, Bouchet-Seraphin C, Bolsee J, Halbout M, Graff J, Vertommen D, Muccioli GG, Seta N, Cuisset JM, Dabaj I, Quijano-Roy S, Grahn A, Van Schaftingen E, Bommer GT. Nat Commun. 2016 May 19;7:11534. doi: 10.1038/ncomms11534. PubMed |
| MYC Is a Crucial Mediator of TGFbeta-Induced Invasion in Basal Breast Cancer. Cichon MA, Moruzzi ME, Shqau TA, Miller E, Mehner C, Ethier SP, Copland JA, Radisky ES, Radisky DC. Cancer Res. 2016 Jun 15;76(12):3520-30. doi: 10.1158/0008-5472.CAN-15-3465. Epub 2016 Apr 13. PubMed |
| Opposing Regulation of the EGF Receptor: A Molecular Switch Controlling Cytomegalovirus Latency and Replication. Buehler J, Zeltzer S, Reitsma J, Petrucelli A, Umashankar M, Rak M, Zagallo P, Schroeder J, Terhune S, Goodrum F. PLoS Pathog. 2016 May 24;12(5):e1005655. doi: 10.1371/journal.ppat.1005655. eCollection 2016 May. PubMed |
| Low-Affinity Neurotrophin Receptor p75 Promotes the Transduction of Targeted Lentiviral Vectors to Cholinergic Neurons of Rat Basal Forebrain. Antyborzec I, O'Leary VB, Dolly JO, Ovsepian SV. Neurotherapeutics. 2016 Oct;13(4):859-870. PubMed |
| Measuring IL-1beta Processing by Bioluminescence Sensors II: The iGLuc System. Bartok E, Kampes M, Hornung V. Methods Mol Biol. 2016;1417:97-113. doi: 10.1007/978-1-4939-3566-6_6. PubMed |
| Forced expression of Hnf4a induces hepatic gene activation through directed differentiation. Yahoo N, Pournasr B, Rostamzadeh J, Fathi F. Biochem Biophys Res Commun. 2016 Aug 5;476(4):313-8. doi: 10.1016/j.bbrc.2016.05.119. Epub 2016 May 24. PubMed |
| A C-terminally truncated mouse Best3 splice variant targets and alters the ion balance in lysosome-endosome hybrids and the endoplasmic reticulum. Wu L, Sun Y, Ma L, Zhu J, Zhang B, Pan Q, Li Y, Liu H, Diao A, Li Y. Sci Rep. 2016 Jun 6;6:27332. doi: 10.1038/srep27332. PubMed |
| Atg7 suppression enhances chemotherapeutic agent sensitivity and overcomes stroma-mediated chemoresistance in acute myeloid leukemia. Piya S, Kornblau SM, Ruvolo VR, Mu H, Ruvolo PP, McQueen T, Davis RE, Hail N Jr, Kantarjian H, Andreeff M, Borthakur G. Blood. 2016 Jun 7. pii: blood-2016-01-692244. PubMed |
| shRNA-Induced Gene Knockdown In Vivo to Investigate Neutrophil Function. Basit A, Tang W, Wu D. Methods Mol Biol. 2016;1407:169-77. doi: 10.1007/978-1-4939-3480-5_13. PubMed |
Co-repressor CBFA2T2 regulates pluripotency and germline development.
Tu S, Narendra V, Yamaji M, Vidal SE, Rojas LA, Wang X, Kim SY, Garcia BA, Tuschl T, Stadtfeld M, Reinberg D.
Nature. 2016 Jun 8;534(7607):387-90. doi: 10.1038/nature18004.
PubMed
Associated Plasmids |
| Cell-death-inducing DFFA-like Effector B Contributes to the Assembly of Hepatitis C Virus (HCV) Particles and Interacts with HCV NS5A. Cai H, Yao W, Li L, Li X, Hu L, Mai R, Peng T. Sci Rep. 2016 Jun 10;6:27778. doi: 10.1038/srep27778. PubMed |
| TMEM16F Regulates Baseline Phosphatidylserine Exposure and Cell Viability in Human Embryonic Kidney Cells. Schenk LK, Schulze U, Henke S, Weide T, Pavenstadt H. Cell Physiol Biochem. 2016;38(6):2452-63. doi: 10.1159/000445596. Epub 2016 Jun 13. PubMed |
| N-cadherin is Key to Expression of the Nucleus Pulposus Cell Phenotype under Selective Substrate Culture Conditions. Hwang PY, Jing L, Chen J, Lim FL, Tang R, Choi H, Cheung KM, Risbud MV, Gersbach CA, Guilak F, Leung VY, Setton LA. Sci Rep. 2016 Jun 13;6:28038. doi: 10.1038/srep28038. PubMed |
| Suppression of Spleen Tyrosine Kinase (Syk) by Histone Deacetylation Promotes, Whereas BAY61-3606, a Synthetic Syk Inhibitor Abrogates Colonocyte Apoptosis by ERK Activation. Dasgupta N, Thakur BK, Ta A, Dutta P, Das S. J Cell Biochem. 2016 Jun 13. doi: 10.1002/jcb.25625. PubMed |
| MicroRNA-181b inhibits thrombin-mediated endothelial activation and arterial thrombosis by targeting caspase recruitment domain family member 10. Lin J, He S, Sun X, Franck G, Deng Y, Yang D, Haemmig S, Wara AK, Icli B, Li D, Feinberg MW. FASEB J. 2016 Jun 13. pii: fj.201500163R. PubMed |
| The Rac-GAP alpha2-chimaerin regulates hippocampal dendrite and spine morphogenesis. Valdez CM, Murphy GG, Beg AA. Mol Cell Neurosci. 2016 Jun 11;75:14-26. doi: 10.1016/j.mcn.2016.06.002. PubMed |
| Engineering of Isogenic Cells Deficient for MR1 with a CRISPR/Cas9 Lentiviral System: Tools To Study Microbial Antigen Processing and Presentation to Human MR1-Restricted T Cells. Laugel B, Lloyd A, Meermeier EW, Crowther MD, Connor TR, Dolton G, Miles JJ, Burrows SR, Gold MC, Lewinsohn DM, Sewell AK. J Immunol. 2016 Jun 15. pii: 1501402. PubMed |
| Preventing Plasmon Coupling between Gold Nanorods Improves the Sensitivity of Photoacoustic Detection of Labeled Stem Cells in Vivo. Comenge J, Fragueiro O, Sharkey J, Taylor A, Held M, Burton NC, Park BK, Wilm B, Murray P, Brust M, Levy R. ACS Nano. 2016 Jul 26;10(7):7106-16. doi: 10.1021/acsnano.6b03246. Epub 2016 Jun 20. PubMed |
AMPK-SKP2-CARM1 signalling cascade in transcriptional regulation of autophagy.
Shin HR, Kim H, Oh S, Lee JG, Kee M, Ko HJ, Kweon MN, Won KJ, Baek SH.
Nature. 2016 Jun 15. doi: 10.1038/nature18014.
PubMed
Associated Plasmids |
| Autophagy regulates spermatid differentiation via degradation of PDLIM1. Shang Y, Wang H, Jia P, Zhao H, Liu C, Liu W, Song Z, Xu Z, Yang L, Wang Y, Li W. Autophagy. 2016 Sep;12(9):1575-92. doi: 10.1080/15548627.2016.1192750. Epub 2016 Jun 16. PubMed |
| Hypoxia promotes noncanonical autophagy in nucleus pulposus cells independent of MTOR and HIF1A signaling. Choi H, Merceron C, Mangiavini L, Seifert EL, Schipani E, Shapiro IM, Risbud MV. Autophagy. 2016 Sep;12(9):1631-46. doi: 10.1080/15548627.2016.1192753. Epub 2016 Jun 17. PubMed |
| Conditional RNAi Using the Lentiviral GLTR System. Pfeiffenberger E, Sigl R, Geley S. Methods Mol Biol. 2016;1448:121-38. doi: 10.1007/978-1-4939-3753-0_10. PubMed |
| Dynamic Imaging Reveals Coordinate Effects of Cyclic Stretch and Substrate Stiffness on Endothelial Integrity. Dan A, Huang RB, Leckband DE. Ann Biomed Eng. 2016 Jun 17. PubMed |
| Chromatin remodeling gene AT-rich interactive domain-containing protein 1A suppresses gastric cancer cell proliferation by targeting PIK3CA and PDK1. Zhang Q, Yan HB, Wang J, Cui SJ, Wang XQ, Jiang YH, Feng L, Yang PY, Liu F. Oncotarget. 2016 Jul 19;7(29):46127-46141. doi: 10.18632/oncotarget.10060. PubMed |
| The C9orf72 protein interacts with Rab1a and the ULK1 complex to regulate initiation of autophagy. Webster CP, Smith EF, Bauer CS, Moller A, Hautbergue GM, Ferraiuolo L, Myszczynska MA, Higginbottom A, Walsh MJ, Whitworth AJ, Kaspar BK, Meyer K, Shaw PJ, Grierson AJ, De Vos KJ. EMBO J. 2016 Jun 22. pii: e201694401. PubMed |
| Agonist-Activated Bombyx Corazonin Receptor Is Internalized via an Arrestin-Dependent and Clathrin-Independent Pathway. Yang J, Shen Z, Jiang X, Yang H, Huang H, Jin L, Chen Y, Shi L, Zhou N. Biochemistry. 2016 Jul 19;55(28):3874-87. doi: 10.1021/acs.biochem.6b00250. Epub 2016 Jul 8. PubMed |
| Angiopoietin-2 promotes ER+ breast cancer cell survival in bone marrow niche. Han HH, Kim BG, Lee JH, Kang S, Kim JE, Cho NH. Endocr Relat Cancer. 2016 Aug;23(8):609-23. doi: 10.1530/ERC-16-0086. Epub 2016 Jun 27. PubMed |
| A PBX1 transcriptional network controls dopaminergic neuron development and is impaired in Parkinson's disease. Villaescusa JC, Li B, Toledo EM, Rivetti di Val Cervo P, Yang S, Stott SR, Kaiser K, Islam S, Gyllborg D, Laguna-Goya R, Landreh M, Lonnerberg P, Falk A, Bergman T, Barker RA, Linnarsson S, Selleri L, Arenas E. EMBO J. 2016 Sep 15;35(18):1963-78. doi: 10.15252/embj.201593725. Epub 2016 Jun 28. PubMed |
| Multiple genetically engineered humanized microenvironments in a single mouse. Lee J, Heckl D, Parekkadan B. Biomater Res. 2016 Jun 28;20:19. doi: 10.1186/s40824-016-0066-2. eCollection 2016. PubMed |
| Practical Considerations for Using Pooled Lentiviral CRISPR Libraries. McDade JR, Waxmonsky NC, Swanson LE, Fan M. Curr Protoc Mol Biol. 2016 Jul 1;115:31.5.1-31.5.13. doi: 10.1002/cpmb.8. PubMed |
| Evaluation of AD-MSC (adipose-derived mesenchymal stem cells) as a vehicle for IFN-beta delivery in experimental autoimmune encephalomyelitis. Mohammadzadeh A, Pourfathollah AA, Shahrokhi S, Fallah A, Tahoori MT, Amari A, Forouzandeh M, Soleimani M. Clin Immunol. 2016 Aug;169:98-106. doi: 10.1016/j.clim.2016.06.015. Epub 2016 Jul 1. PubMed |
| The Interferon-Stimulated Gene Ifitm3 Restricts West Nile Virus Infection and Pathogenesis. Gorman MJ, Poddar S, Farzan M, Diamond MS. J Virol. 2016 Aug 26;90(18):8212-25. doi: 10.1128/JVI.00581-16. Print 2016 Sep 15. PubMed |
| Halofuginone and artemisinin synergistically arrest cancer cells at the G1/G0 phase by upregulating p21Cip1 and p27Kip1. Chen G, Gong R, Shi X, Yang D, Zhang G, Lu A, Yue J, Bian Z. Oncotarget. 2016 Aug 2;7(31):50302-50314. doi: 10.18632/oncotarget.10367. PubMed |
| Zbtb1 Safeguards Genome Integrity and Prevents p53-Mediated Apoptosis in Proliferating Lymphoid Progenitors. Cao X, Lu Y, Zhang X, Kovalovsky D. J Immunol. 2016 Aug 15;197(4):1199-211. doi: 10.4049/jimmunol.1600013. Epub 2016 Jul 8. PubMed |
| Evaluation of Immortalized AVPV- and Arcuate-Specific Neuronal Kisspeptin Cell Lines to Elucidate Potential Mechanisms of Estrogen Responsiveness and Temporal Gene Expression in Females. Jacobs DC, Veitch RE, Chappell PE. Endocrinology. 2016 Sep;157(9):3410-9. doi: 10.1210/en.2016-1294. Epub 2016 Jul 13. PubMed |
| Assessment of Anti-TNF-alpha Activities in Keratinocytes Expressing Inducible TNF- alpha: A Novel Tool for Anti-TNF-alpha Drug Screening. Udommethaporn S, Tencomnao T, McGowan EM, Boonyaratanakornkit V. PLoS One. 2016 Jul 14;11(7):e0159151. doi: 10.1371/journal.pone.0159151. eCollection 2016. PubMed |
| Transcription factor NFE2L2/NRF2 is a regulator of macroautophagy genes. Pajares M, Jimenez-Moreno N, Garcia-Yague AJ, Escoll M, de Ceballos ML, Van Leuven F, Rabano A, Yamamoto M, Rojo AI, Cuadrado A. Autophagy. 2016 Oct 2;12(10):1902-1916. Epub 2016 Jul 18. PubMed |
| A USP28-53BP1-p53-p21 signaling axis arrests growth after centrosome loss or prolonged mitosis. Lambrus BG, Daggubati V, Uetake Y, Scott PM, Clutario KM, Sluder G, Holland AJ. J Cell Biol. 2016 Jul 18;214(2):143-53. doi: 10.1083/jcb.201604054. PubMed |
| Epstein-Barr Virus Oncoprotein LMP1 Mediates Epigenetic Changes in Host Gene Expression through PARP1. Martin KA, Lupey LN, Tempera I. J Virol. 2016 Sep 12;90(19):8520-30. doi: 10.1128/JVI.01180-16. Print 2016 Oct 1. PubMed |
| The Interferon-Stimulated Gene IFITM3 Restricts Infection and Pathogenesis of Arthritogenic and Encephalitic Alphaviruses. Poddar S, Hyde JL, Gorman MJ, Farzan M, Diamond MS. J Virol. 2016 Sep 12;90(19):8780-94. doi: 10.1128/JVI.00655-16. Print 2016 Oct 1. PubMed |
| AMP-activated protein kinase is involved in the activation of the Fanconi anemia/BRCA pathway in response to DNA interstrand crosslinks. Chun MJ, Kim S, Hwang SK, Kim BS, Kim HG, Choi HI, Kim JH, Goh SH, Lee CH. Oncotarget. 2016 Aug 16;7(33):53642-53653. doi: 10.18632/oncotarget.10686. PubMed |
| VE-cadherin interacts with cell polarity protein Pals1 to regulate vascular lumen formation. Brinkmann BF, Steinbacher T, Hartmann C, Kummer D, Pajonczyk D, Mirzapourshafiyi F, Nakayama M, Weide T, Gerke V, Ebnet K. Mol Biol Cell. 2016 Sep 15;27(18):2811-21. doi: 10.1091/mbc.E16-02-0127. Epub 2016 Jul 27. PubMed |
| Ubiquitously expressed genes participate in cell-specific functions via alternative promoter usage. Feng G, Tong M, Xia B, Luo GZ, Wang M, Xie D, Wan H, Zhang Y, Zhou Q, Wang XJ. EMBO Rep. 2016 Sep;17(9):1304-13. doi: 10.15252/embr.201541476. Epub 2016 Jul 27. PubMed |
| EZH2-mediated Puma gene repression regulates non-small cell lung cancer cell proliferation and cisplatin-induced apoptosis. Liu H, Li W, Yu X, Gao F, Duan Z, Ma X, Tan S, Yuan Y, Liu L, Wang J, Zhou X, Yang Y. Oncotarget. 2016 Aug 30;7(35):56338-56354. doi: 10.18632/oncotarget.10841. PubMed |
| Regulation of B-cell development and tolerance by different members of the miR-17 approximately 92 family microRNAs. Lai M, Gonzalez-Martin A, Cooper AB, Oda H, Jin HY, Shepherd J, He L, Zhu J, Nemazee D, Xiao C. Nat Commun. 2016 Aug 2;7:12207. doi: 10.1038/ncomms12207. PubMed |
| Axitinib blocks Wnt/beta-catenin signaling and directs asymmetric cell division in cancer. Qu Y, Gharbi N, Yuan X, Olsen JR, Blicher P, Dalhus B, Brokstad KA, Lin B, Oyan AM, Zhang W, Kalland KH, Ke X. Proc Natl Acad Sci U S A. 2016 Aug 16;113(33):9339-44. doi: 10.1073/pnas.1604520113. Epub 2016 Aug 1. PubMed |
| Human ULK1 Variation and Susceptibility to Mycobacterium tuberculosis Infection. Horne DJ, Graustein AD, Shah JA, Peterson G, Savlov M, Steele S, Narita M, Hawn TR. J Infect Dis. 2016 Oct 15;214(8):1260-7. doi: 10.1093/infdis/jiw347. Epub 2016 Aug 2. PubMed |
| Microfluidic device for the formation of optically excitable, three-dimensional, compartmentalized motor units. Uzel SG, Platt RJ, Subramanian V, Pearl TM, Rowlands CJ, Chan V, Boyer LA, So PT, Kamm RD. Sci Adv. 2016 Aug 3;2(8):e1501429. doi: 10.1126/sciadv.1501429. eCollection 2016 Aug. PubMed |
| Optimal Lentivirus Production and Cell Culture Conditions Necessary to Successfully Transduce Primary Human Bronchial Epithelial Cells. Baumlin-Schmid N, Salathe M, Fregien NL. J Vis Exp. 2016 Jul 22;(113). doi: 10.3791/54176. PubMed |
| Protocol for the Direct Conversion of Murine Embryonic Fibroblasts into Trophoblast Stem Cells. Kubaczka C, Schorle H. J Vis Exp. 2016 Jul 25;(113). doi: 10.3791/54277. PubMed |
| CXCR4 Overexpression in Human Adipose Tissue-Derived Stem Cells Improves Homing and Engraftment in an Animal Limb Ischemia Model. Kim M, Kim DI, Kim EK, Kim CW. Cell Transplant. 2017 Feb 16;26(2):191-204. doi: 10.3727/096368916X692708. Epub 2016 Aug 5. PubMed |
| MCPIP-1, Alias Regnase-1, Controls Epithelial Inflammation by Posttranscriptional Regulation of IL-8 Production. Dobosz E, Wilamowski M, Lech M, Bugara B, Jura J, Potempa J, Koziel J. J Innate Immun. 2016;8(6):564-578. Epub 2016 Aug 12. PubMed |
| PTEN loss is associated with a poor response to trastuzumab in HER2-overexpressing gastroesophageal adenocarcinoma. Deguchi Y, Okabe H, Oshima N, Hisamori S, Minamiguchi S, Muto M, Sakai Y. Gastric Cancer. 2016 Aug 12. PubMed |
| STAT3-induced WDR1 overexpression promotes breast cancer cell migration. Lee JH, Kim JE, Kim BG, Han HH, Kang S, Cho NH. Cell Signal. 2016 Nov;28(11):1753-60. doi: 10.1016/j.cellsig.2016.08.006. Epub 2016 Aug 10. PubMed |
| PPP2R5B, a regulatory subunit of PP2A, contributes to adipocyte insulin resistance. Beg M, Srivastava A, Shankar K, Varshney S, Rajan S, Gupta A, Kumar D, Gaikwad AN. Mol Cell Endocrinol. 2016 Dec 5;437:97-107. doi: 10.1016/j.mce.2016.08.016. Epub 2016 Aug 10. PubMed |
| Exposure to human immunodeficiency virus/hepatitis C virus in hepatic and stellate cell lines reveals cooperative profibrotic transcriptional activation between viruses and cell types. Salloum S, Holmes JA, Jindal R, Bale SS, Brisac C, Alatrakchi N, Lidofsky A, Kruger AJ, Fusco DN, Luther J, Schaefer EA, Lin W, Yarmush ML, Chung RT. Hepatology. 2016 Dec;64(6):1951-1968. doi: 10.1002/hep.28766. Epub 2016 Oct 5. PubMed |
| Novel biomarkers of resistance of pancreatic cancer cells to oncolytic vesicular stomatitis virus. Hastie E, Cataldi M, Moerdyk-Schauwecker MJ, Felt SA, Steuerwald N, Grdzelishvili VZ. Oncotarget. 2016 Sep 20;7(38):61601-61618. doi: 10.18632/oncotarget.11202. PubMed |
| Long noncoding RNA C17orf91 is a potential prognostic marker and functions as an oncogene in ovarian cancer. Li J, Yu H, Xi M, Lu X. J Ovarian Res. 2016 Aug 17;9(1):49. doi: 10.1186/s13048-016-0258-3. PubMed |
| TSC2 N-terminal lysine acetylation status affects to its stability modulating mTORC1 signaling and autophagy. Garcia-Aguilar A, Guillen C, Nellist M, Bartolome A, Benito M. Biochim Biophys Acta. 2016 Nov;1863(11):2658-2667. doi: 10.1016/j.bbamcr.2016.08.006. Epub 2016 Aug 16. PubMed |
| Protein phosphatase 2A regulatory subunit B56beta modulates erythroid differentiation. Wu J, Wang J, Zeng X, Chen Y, Xia J, Wang S, Huang Z, Chen W, Shen Z. Biochem Biophys Res Commun. 2016 Sep 23;478(3):1179-84. doi: 10.1016/j.bbrc.2016.08.090. Epub 2016 Aug 17. PubMed |
| Telomerase reverse transcriptase induces basal and amino acid starvation-induced autophagy through mTORC1. Ali M, Devkota S, Roh JI, Lee J, Lee HW. Biochem Biophys Res Commun. 2016 Sep 23;478(3):1198-204. doi: 10.1016/j.bbrc.2016.08.094. Epub 2016 Aug 18. PubMed |
| A Role for Nuclear F-Actin Induction in Human Cytomegalovirus Nuclear Egress. Wilkie AR, Lawler JL, Coen DM. MBio. 2016 Aug 23;7(4). pii: e01254-16. doi: 10.1128/mBio.01254-16. PubMed |
| RALB provides critical survival signals downstream of Ras in acute myeloid leukemia. Eckfeldt CE, Pomeroy EJ, Lee RD, Hazen KS, Lee LA, Moriarity BS, Largaespada DA. Oncotarget. 2016 Oct 4;7(40):65147-65156. doi: 10.18632/oncotarget.11431. PubMed |
| Cell-Type-Specific Alternative Splicing Governs Cell Fate in the Developing Cerebral Cortex. Zhang X, Chen MH, Wu X, Kodani A, Fan J, Doan R, Ozawa M, Ma J, Yoshida N, Reiter JF, Black DL, Kharchenko PV, Sharp PA, Walsh CA. Cell. 2016 Aug 25;166(5):1147-1162.e15. doi: 10.1016/j.cell.2016.07.025. PubMed |
| Histone H3K27 Trimethylation Modulates 5-Fluorouracil Resistance by Inhibiting PU.1 Binding to the DPYD Promoter. Wu R, Nie Q, Tapper EE, Jerde CR, Dunlap GS, Shrestha S, Elraiyah TA, Offer SM, Diasio RB. Cancer Res. 2016 Nov 1;76(21):6362-6373. Epub 2016 Aug 30. PubMed |
| Natural Killer Cell Evasion Is Essential for Infection by Rhesus Cytomegalovirus. Sturgill ER, Malouli D, Hansen SG, Burwitz BJ, Seo S, Schneider CL, Womack JL, Verweij MC, Ventura AB, Bhusari A, Jeffries KM, Legasse AW, Axthelm MK, Hudson AW, Sacha JB, Picker LJ, Fruh K. PLoS Pathog. 2016 Aug 31;12(8):e1005868. doi: 10.1371/journal.ppat.1005868. eCollection 2016 Aug. PubMed |
| High-Throughput Screening of Tyrosine Kinase Inhibitor Resistant Genes in CML. Ma L, Roderick J, Kelliher MA, Green MR. Methods Mol Biol. 2016;1465:159-73. doi: 10.1007/978-1-4939-4011-0_14. PubMed |
| Roles for E-cadherin cell surface regulation in cancer. Petrova YI, Schecterson L, Gumbiner BM. Mol Biol Cell. 2016 Nov 1;27(21):3233-3244. Epub 2016 Aug 31. PubMed |
| Deregulation of the Hippo pathway in mouse mammary stem cells promotes mammary tumorigenesis. Li H, Gumbiner BM. Mamm Genome. 2016 Dec;27(11-12):556-564. Epub 2016 Sep 6. PubMed |
| PtdIns(4,5)P2 signaling regulates ATG14 and autophagy. Tan X, Thapa N, Liao Y, Choi S, Anderson RA. Proc Natl Acad Sci U S A. 2016 Sep 27;113(39):10896-901. doi: 10.1073/pnas.1523145113. Epub 2016 Sep 12. PubMed |
| Tbx3 fosters pancreatic cancer growth by increased angiogenesis and activin/nodal-dependent induction of stemness. Perkhofer L, Walter K, Costa IG, Carrasco MC, Eiseler T, Hafner S, Genze F, Zenke M, Bergmann W, Illing A, Hohwieler M, Kohntop R, Lin Q, Holzmann KH, Seufferlein T, Wagner M, Liebau S, Hermann PC, Kleger A, Muller M. Stem Cell Res. 2016 Sep;17(2):367-378. doi: 10.1016/j.scr.2016.08.007. Epub 2016 Aug 10. PubMed |
| Involvement of peroxisome proliferator activated receptor-gamma in the anti-inflammatory effects of atorvastatin in oxygen-glucose deprivation/reperfusion-stimulated RAW264.7 murine macrophages. Li HY, Su YY, Zhang YF, Liu ZQ, Hua BJ. Mol Med Rep. 2016 Nov;14(5):4055-4062. doi: 10.3892/mmr.2016.5742. Epub 2016 Sep 15. PubMed |
| Chronic Kappa opioid receptor activation modulates NR2B: Implication in treatment resistant depression. Dogra S, Kumar A, Umrao D, Sahasrabuddhe AA, Yadav PN. Sci Rep. 2016 Sep 16;6:33401. doi: 10.1038/srep33401. PubMed |
| An alternative splicing program promotes adipose tissue thermogenesis. Vernia S, Edwards YJ, Han MS, Cavanagh-Kyros J, Barrett T, Kim JK, Davis RJ. Elife. 2016 Sep 16;5. pii: e17672. doi: 10.7554/eLife.17672. PubMed |
| Localized translation regulates cell adhesion and transendothelial migration. Bergeman J, Caillier A, Houle F, Gagne LM, Huot ME. J Cell Sci. 2016 Nov 1;129(21):4105-4117. Epub 2016 Sep 16. PubMed |
| Targeting the metabolic pathway of human colon cancer overcomes resistance to TRAIL-induced apoptosis. Carr RM, Qiao G, Qin J, Jayaraman S, Prabhakar BS, Maker AV. Cell Death Discov. 2016 Sep 12;2:16067. doi: 10.1038/cddiscovery.2016.67. eCollection 2016. PubMed |
| Cadm3 (Necl-1) interferes with the activation of the PI3 kinase/Akt signaling cascade and inhibits Schwann cell myelination in vitro. Chen MS, Kim H, Jagot-Lacoussiere L, Maurel P. Glia. 2016 Dec;64(12):2247-2262. doi: 10.1002/glia.23072. Epub 2016 Sep 23. PubMed |
| PD-1 mediates functional exhaustion of activated NK cells in patients with Kaposi sarcoma. Beldi-Ferchiou A, Lambert M, Dogniaux S, Vely F, Vivier E, Olive D, Dupuy S, Levasseur F, Zucman D, Lebbe C, Sene D, Hivroz C, Caillat-Zucman S. Oncotarget. 2016 Nov 8;7(45):72961-72977. doi: 10.18632/oncotarget.12150. PubMed |
| Endogenous TRPV1 stimulation leads to the activation of the inositol phospholipid pathway necessary for sustained Ca2+ oscillations. Pecze L, Blum W, Henzi T, Schwaller B. Biochim Biophys Acta. 2016 Dec;1863(12):2905-2915. doi: 10.1016/j.bbamcr.2016.09.013. Epub 2016 Sep 20. PubMed |
| AEG-1 promotes mesenchymal transition through the activation of Rho GTPases in human glioblastoma cells. Park SY, Choi M, Park D, Jeong M, Ahn KS, Lee J, Fisher PB, Yun M, Lee SG. Oncol Rep. 2016 Nov;36(5):2641-2646. doi: 10.3892/or.2016.5106. Epub 2016 Sep 19. PubMed |
| Gene expression elucidates functional impact of polygenic risk for schizophrenia. Fromer M, Roussos P, Sieberts SK, Johnson JS, Kavanagh DH, Perumal TM, Ruderfer DM, Oh EC, Topol A, Shah HR, Klei LL, Kramer R, Pinto D, Gumus ZH, Cicek AE, Dang KK, Browne A, Lu C, Xie L, Readhead B, Stahl EA, Xiao J, Parvizi M, Hamamsy T, Fullard JF, Wang YC, Mahajan MC, Derry JM, Dudley JT, Hemby SE, Logsdon BA, Talbot K, Raj T, Bennett DA, De Jager PL, Zhu J, Zhang B, Sullivan PF, Chess A, Purcell SM, Shinobu LA, Mangravite LM, Toyoshiba H, Gur RE, Hahn CG, Lewis DA, Haroutunian V, Peters MA, Lipska BK, Buxbaum JD, Schadt EE, Hirai K, Roeder K, Brennand KJ, Katsanis N, Domenici E, Devlin B, Sklar P. Nat Neurosci. 2016 Nov;19(11):1442-1453. doi: 10.1038/nn.4399. Epub 2016 Sep 26. PubMed |
| SPINK6 Promotes Metastasis of Nasopharyngeal Carcinoma via Binding and Activation of Epithelial Growth Factor Receptor. Zheng LS, Yang JP, Cao Y, Peng LX, Sun R, Xie P, Wang MY, Meng DF, Luo DH, Zou X, Chen MY, Mai HQ, Guo L, Guo X, Shao JY, Huang BJ, Zhang W, Qian CN. Cancer Res. 2017 Jan 15;77(2):579-589. doi: 10.1158/0008-5472.CAN-16-1281. Epub 2016 Sep 26. PubMed |
| Functional receptor molecules CD300lf and CD300ld within the CD300 family enable murine noroviruses to infect cells. Haga K, Fujimoto A, Takai-Todaka R, Miki M, Doan YH, Murakami K, Yokoyama M, Murata K, Nakanishi A, Katayama K. Proc Natl Acad Sci U S A. 2016 Oct 11;113(41):E6248-E6255. Epub 2016 Sep 28. PubMed |
| mTOR and neuronal cell cycle reentry: How impaired brain insulin signaling promotes Alzheimer's disease. Norambuena A, Wallrabe H, McMahon L, Silva A, Swanson E, Khan SS, Baerthlein D, Kodis E, Oddo S, Mandell JW, Bloom GS. Alzheimers Dement. 2016 Sep 29. pii: S1552-5260(16)32895-3. doi: 10.1016/j.jalz.2016.08.015. PubMed |
| LDB1 overexpression is a negative prognostic factor in colorectal cancer. Garcia SA, Swiersy A, Radhakrishnan P, Branchi V, Kanth Nanduri L, Gyorffy B, Betzler AM, Bork U, Kahlert C, Reissfelder C, Rahbari NN, Weitz J, Scholch S. Oncotarget. 2016 Dec 20;7(51):84258-84270. doi: 10.18632/oncotarget.12481. PubMed |
| Construction of Conveniently Screening pLKO.1-TRC Vector Tagged with TurboGFP. Xu J, Zhu W, Guo Y, Jiang C, Hussain N, Meng L, Lu S. Appl Biochem Biotechnol. 2016 Oct 11. PubMed |
| L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity. Geiger R, Rieckmann JC, Wolf T, Basso C, Feng Y, Fuhrer T, Kogadeeva M, Picotti P, Meissner F, Mann M, Zamboni N, Sallusto F, Lanzavecchia A. Cell. 2016 Oct 20;167(3):829-842.e13. doi: 10.1016/j.cell.2016.09.031. Epub 2016 Oct 13. PubMed |
| Snail1-dependent p53 repression regulates expansion and activity of tumour-initiating cells in breast cancer. Ni T, Li XY, Lu N, An T, Liu ZP, Fu R, Lv WC, Zhang YW, Xu XJ, Grant Rowe R, Lin YS, Scherer A, Feinberg T, Zheng XQ, Chen BA, Liu XS, Guo QL, Wu ZQ, Weiss SJ. Nat Cell Biol. 2016 Nov;18(11):1221-1232. doi: 10.1038/ncb3425. Epub 2016 Oct 17. PubMed |
| Engineering prokaryotic channels for control of mammalian tissue excitability. Nguyen HX, Kirkton RD, Bursac N. Nat Commun. 2016 Oct 18;7:13132. doi: 10.1038/ncomms13132. PubMed |
| A pH- and ionic strength-dependent conformational change in the neck region regulates DNGR-1 function in dendritic cells. Hanc P, Schulz O, Fischbach H, Martin SR, Kjaer S, Reis E Sousa C. EMBO J. 2016 Nov 15;35(22):2484-2497. Epub 2016 Oct 17. PubMed |
| Single Amino Acid Substitution N659D in HIV-2 Envelope Glycoprotein (Env) Impairs Viral Release and Hampers BST-2 Antagonism. Dufrasne FE, Lombard C, Goubau P, Ruelle J. Viruses. 2016 Oct 14;8(10). pii: E285. PubMed |
| HOXB4 Gene Expression Is Regulated by CDX2 in Intestinal Epithelial Cells. Jorgensen S, Coskun M, Homburg KM, Pedersen OB, Troelsen JT. PLoS One. 2016 Oct 18;11(10):e0164555. doi: 10.1371/journal.pone.0164555. eCollection 2016. PubMed |
| Mechanisms of leukemia resistance to antibody dependent cellular cytotoxicity. Dubrovsky L, Brea EJ, Pankov D, Casey E, Dao T, Liu C, Scheinberg DA. Oncoimmunology. 2016 Aug 3;5(9):e1211221. eCollection 2016. PubMed |
| SIKs control osteocyte responses to parathyroid hormone. Wein MN, Liang Y, Goransson O, Sundberg TB, Wang J, Williams EA, O'Meara MJ, Govea N, Beqo B, Nishimori S, Nagano K, Brooks DJ, Martins JS, Corbin B, Anselmo A, Sadreyev R, Wu JY, Sakamoto K, Foretz M, Xavier RJ, Baron R, Bouxsein ML, Gardella TJ, Divieti-Pajevic P, Gray NS, Kronenberg HM. Nat Commun. 2016 Oct 19;7:13176. doi: 10.1038/ncomms13176. PubMed |
| Complementary Roles of Estrogen-Related Receptors in Brown Adipocyte Thermogenic Function. Gantner ML, Hazen BC, Eury E, Brown EL, Kralli A. Endocrinology. 2016 Dec;157(12):4770-4781. Epub 2016 Oct 20. PubMed |
| MIR144* inhibits antimicrobial responses against Mycobacterium tuberculosis in human monocytes and macrophages by targeting the autophagy protein DRAM2. Kim JK, Lee HM, Park KS, Shin DM, Kim TS, Kim YS, Suh HW, Kim SY, Kim IS, Kim JM, Son JW, Sohn KM, Jung SS, Chung C, Han SB, Yang CS, Jo EK. Autophagy. 2016 Oct 20:1-19. doi: 10.1080/15548627.2016.1241922. PubMed |
| RNA-binding protein QKI-5 inhibits the proliferation of clear cell renal cell carcinoma via post-transcriptional stabilization of RASA1 mRNA. Zhang RL, Yang JP, Peng LX, Zheng LS, Xie P, Wang MY, Cao Y, Zhang ZL, Zhou FJ, Qian CN, Bao YX. Cell Cycle. 2016 Nov 16;15(22):3094-3104. Epub 2016 Oct 21. PubMed |
| Toxic PR Poly-Dipeptides Encoded by the C9orf72 Repeat Expansion Target LC Domain Polymers. Lin Y, Mori E, Kato M, Xiang S, Wu L, Kwon I, McKnight SL. Cell. 2016 Oct 20;167(3):789-802.e12. doi: 10.1016/j.cell.2016.10.003. PubMed |
| The Hippo pathway regulates human megakaryocytic differentiation. Lorthongpanich C, Jiamvoraphong N, Supraditaporn K, Klaihmon P, U-Pratya Y, Issaragrisil S. Thromb Haemost. 2017 Jan 5;117(1):116-126. doi: 10.1160/TH16-07-0564. Epub 2016 Oct 27. PubMed |
| Role of FAST Kinase Domains 3 (FASTKD3) in Post-transcriptional Regulation of Mitochondrial Gene Expression. Boehm E, Zornoza M, Jourdain AA, Delmiro Magdalena A, Garcia-Consuegra I, Torres Merino R, Orduna A, Martin MA, Martinou JC, De la Fuente MA, Simarro M. J Biol Chem. 2016 Dec 9;291(50):25877-25887. Epub 2016 Oct 27. PubMed |
| The Andes Virus Nucleocapsid Protein Directs Basal Endothelial Cell Permeability by Activating RhoA. Gorbunova EE, Simons MJ, Gavrilovskaya IN, Mackow ER. MBio. 2016 Oct 25;7(5). pii: e01747-16. doi: 10.1128/mBio.01747-16. PubMed |
| Eomeshi NK Cells in Human Liver Are Long-Lived and Do Not Recirculate but Can Be Replenished from the Circulation. Cuff AO, Robertson FP, Stegmann KA, Pallett LJ, Maini MK, Davidson BR, Male V. J Immunol. 2016 Dec 1;197(11):4283-4291. Epub 2016 Oct 21. PubMed |
| The role of gigaxonin in the degradation of the glial-specific intermediate filament protein GFAP. Lin NH, Huang YS, Opal P, Goldman RD, Messing A, Perng MD. Mol Biol Cell. 2016 Dec 15;27(25):3980-3990. Epub 2016 Oct 26. PubMed |
| Developmental mechanisms of stripe patterns in rodents. Mallarino R, Henegar C, Mirasierra M, Manceau M, Schradin C, Vallejo M, Beronja S, Barsh GS, Hoekstra HE. Nature. 2016 Nov 24;539(7630):518-523. doi: 10.1038/nature20109. Epub 2016 Nov 2. PubMed |
| HIF-KDM3A-MMP12 regulatory circuit ensures trophoblast plasticity and placental adaptations to hypoxia. Chakraborty D, Cui W, Rosario GX, Scott RL, Dhakal P, Renaud SJ, Tachibana M, Rumi MA, Mason CW, Krieg AJ, Soares MJ. Proc Natl Acad Sci U S A. 2016 Nov 15;113(46):E7212-E7221. Epub 2016 Nov 2. PubMed |
| CRISPR/Cas9 editing of induced pluripotent stem cells for engineering inflammation-resistant tissues. Brunger JM, Zutshi A, Willard VP, Gersbach CA, Guilak F. Arthritis Rheumatol. 2016 Nov 3. doi: 10.1002/art.39982. PubMed |
| Human 15-lipoxygenase-1 is a regulator of dendritic-cell spreading and podosome formation. Han H, Liang X, Ekberg M, Kritikou JS, Brunnstrom A, Pelcman B, Matl M, Miao X, Andersson M, Yuan X, Schain F, Parvin S, Melin E, Sjoberg J, Xu D, Westerberg LS, Bjorkholm M, Claesson HE. FASEB J. 2016 Oct 17. pii: fj.201600679RR. PubMed |
| Cellular effects of fluorodeoxyglucose: Global changes in the lipidome and alteration in intracellular transport. Kavaliauskiene S, Torgersen ML, Lingelem AB, Klokk TI, Lintonen T, Simolin H, Ekroos K, Skotland T, Sandvig K. Oncotarget. 2016 Nov 29;7(48):79885-79900. doi: 10.18632/oncotarget.13089. PubMed |
| Fluorescence Reporter-Based Genome-Wide RNA Interference Screening to Identify Alternative Splicing Regulators. Misra A, Green MR. Methods Mol Biol. 2017;1507:1-12. PubMed |
| Notch regulates BMP responsiveness and lateral branching in vessel networks via SMAD6. Mouillesseaux KP, Wiley DS, Saunders LM, Wylie LA, Kushner EJ, Chong DC, Citrin KM, Barber AT, Park Y, Kim JD, Samsa LA, Kim J, Liu J, Jin SW, Bautch VL. Nat Commun. 2016 Nov 11;7:13247. doi: 10.1038/ncomms13247. PubMed |
| Targeted depletion of PIK3R2 induces regression of lung squamous cell carcinoma. Vallejo-Diaz J, Olazabal-Moran M, Cariaga-Martinez AE, Pajares MJ, Flores JM, Pio R, Montuenga LM, Carrera AC. Oncotarget. 2016 Dec 20;7(51):85063-85078. doi: 10.18632/oncotarget.13195. PubMed |
| A Highly Conserved Residue in HIV-1 Nef Alpha Helix 2 Modulates Protein Expression. Johnson AL, Dirk BS, Coutu M, Haeryfar SM, Arts EJ, Finzi A, Dikeakos JD. mSphere. 2016 Nov 9;1(6). pii: e00288-16. eCollection 2016 Nov-Dec. PubMed |
| Tumors overexpressing RNF168 show altered DNA repair and responses to genotoxic treatments, genomic instability and resistance to proteotoxic stress. Chroma K, Mistrik M, Moudry P, Gursky J, Liptay M, Strauss R, Skrott Z, Vrtel R, Bartkova J, Kramara J, Bartek J. Oncogene. 2016 Nov 14. doi: 10.1038/onc.2016.392. PubMed |
| Dual loss of succinate dehydrogenase (SDH) and complex I activity is necessary to recapitulate the metabolic phenotype of SDH mutant tumors. Lorendeau D, Rinaldi G, Boon R, Spincemaille P, Metzger K, Jager C, Christen S, Dong X, Kuenen S, Voordeckers K, Verstreken P, Cassiman D, Vermeersch P, Verfaillie C, Hiller K, Fendt SM. Metab Eng. 2016 Nov 12. pii: S1096-7176(16)30217-8. doi: 10.1016/j.ymben.2016.11.005. PubMed |
In vivo genome editing via CRISPR/Cas9 mediated homology-independent targeted integration.
Suzuki K, Tsunekawa Y, Hernandez-Benitez R, Wu J, Zhu J, Kim EJ, Hatanaka F, Yamamoto M, Araoka T, Li Z, Kurita M, Hishida T, Li M, Aizawa E, Guo S, Chen S, Goebl A, Soligalla RD, Qu J, Jiang T, Fu X, Jafari M, Esteban CR, Berggren WT, Lajara J, Nunez-Delicado E, Guillen P, Campistol JM, Matsuzaki F, Liu GH, Magistretti P, Zhang K, Callaway EM, Zhang K, Belmonte JC.
Nature. 2016 Dec 1;540(7631):144-149. doi: 10.1038/nature20565. Epub 2016 Nov 16.
PubMed
Associated Plasmids |
| SPRTN is a mammalian DNA-binding metalloprotease that resolves DNA-protein crosslinks. Lopez-Mosqueda J, Maddi K, Prgomet S, Kalayil S, Marinovic-Terzic I, Terzic J, Dikic I. Elife. 2016 Nov 17;5. pii: e21491. doi: 10.7554/eLife.21491. PubMed |
| Knockdown of PTRF ameliorates adipocyte differentiation and functionality of human mesenchymal stem cells. Perez-Diaz S, Garcia-Rodriguez B, Gonzalez-Irazabal Y, Valero M, Lagos-Lizan J, Arbones-Mainar JM. Am J Physiol Cell Physiol. 2017 Jan 1;312(1):C83-C91. doi: 10.1152/ajpcell.00246.2016. Epub 2016 Nov 16. PubMed |
| miRNAsong: a web-based tool for generation and testing of miRNA sponge constructs in silico. Barta T, Peskova L, Hampl A. Sci Rep. 2016 Nov 18;6:36625. doi: 10.1038/srep36625. PubMed |
| Low p16INK4a Expression in Early Passage Human Prostate Basal Epithelial Cells Enables Immortalization by Telomerase Expression Alone. Graham MK, Principessa L, Antony L, Meeker AK, Isaacs JT. Prostate. 2016 Nov 8. doi: 10.1002/pros.23276. PubMed |
| Modularized Gold Nanocarriers for TAT-Mediated Delivery of siRNA. Huang X, Lai Y, Braun GB, Reich NO. Small. 2016 Nov 18. doi: 10.1002/smll.201602473. PubMed |
| Epigenetic Activation of WNT5A Drives Glioblastoma Stem Cell Differentiation and Invasive Growth. Hu B, Wang Q, Wang YA, Hua S, Sauve CG, Ong D, Lan ZD, Chang Q, Ho YW, Monasterio MM, Lu X, Zhong Y, Zhang J, Deng P, Tan Z, Wang G, Liao WT, Corley LJ, Yan H, Zhang J, You Y, Liu N, Cai L, Finocchiaro G, Phillips JJ, Berger MS, Spring DJ, Hu J, Sulman EP, Fuller GN, Chin L, Verhaak RG, DePinho RA. Cell. 2016 Nov 17;167(5):1281-1295.e18. doi: 10.1016/j.cell.2016.10.039. PubMed |
| Emerin suppresses Notch signaling by restricting the Notch intracellular domain to the nuclear membrane. Lee B, Lee TH, Shim J. Biochim Biophys Acta. 2017 Feb;1864(2):303-313. doi: 10.1016/j.bbamcr.2016.11.013. Epub 2016 Nov 16. PubMed |
| Pan-cancer analysis of somatic copy-number alterations implicates IRS4 and IGF2 in enhancer hijacking. Weischenfeldt J, Dubash T, Drainas AP, Mardin BR, Chen Y, Stutz AM, Waszak SM, Bosco G, Halvorsen AR, Raeder B, Efthymiopoulos T, Erkek S, Siegl C, Brenner H, Brustugun OT, Dieter SM, Northcott PA, Petersen I, Pfister SM, Schneider M, Solberg SK, Thunissen E, Weichert W, Zichner T, Thomas R, Peifer M, Helland A, Ball CR, Jechlinger M, Sotillo R, Glimm H, Korbel JO. Nat Genet. 2017 Jan;49(1):65-74. doi: 10.1038/ng.3722. Epub 2016 Nov 21. PubMed |
| RNA Sequencing Reveals a Role of TonEBP Transcription Factor in Regulation of Pro-inflammatory Genes in Response to Hyperosmolarity in Healthy Nucleus Pulposus Cells: A HOMEOSTATIC RESPONSE? Johnson ZI, Shapiro IM, Risbud MV. J Biol Chem. 2016 Dec 23;291(52):26686-26697. doi: 10.1074/jbc.M116.757732. Epub 2016 Nov 8. PubMed |
| Merkel Cell Polyomavirus Small T Antigen Promotes Pro-Glycolytic Metabolic Perturbations Required for Transformation. Berrios C, Padi M, Keibler MA, Park DE, Molla V, Cheng J, Lee SM, Stephanopoulos G, Quackenbush J, DeCaprio JA. PLoS Pathog. 2016 Nov 23;12(11):e1006020. doi: 10.1371/journal.ppat.1006020. eCollection 2016 Nov. PubMed |
| Cell-Type-Specific Chromatin States Differentially Prime Squamous Cell Carcinoma Tumor-Initiating Cells for Epithelial to Mesenchymal Transition. Latil M, Nassar D, Beck B, Boumahdi S, Wang L, Brisebarre A, Dubois C, Nkusi E, Lenglez S, Checinska A, Vercauteren Drubbel A, Devos M, Declercq W, Yi R, Blanpain C. Cell Stem Cell. 2016 Nov 16. pii: S1934-5909(16)30359-9. doi: 10.1016/j.stem.2016.10.018. PubMed |
| The anti-tumor drug 2-hydroxyoleic acid (Minerval) stimulates signaling and retrograde transport. Torgersen ML, Klokk TI, Kavaliauskiene S, Klose C, Simons K, Skotland T, Sandvig K. Oncotarget. 2016 Dec 27;7(52):86871-86888. doi: 10.18632/oncotarget.13508. PubMed |
| Scleraxis is essential for tendon differentiation by equine embryonic stem cells and in equine fetal tenocytes. Bavin E, Atkinson F, Barsby T, Guest D. Stem Cells Dev. 2016 Nov 29. PubMed |
| Molecular imaging with engineered physiology. Desai M, Slusarczyk AL, Chapin A, Barch M, Jasanoff A. Nat Commun. 2016 Dec 2;7:13607. doi: 10.1038/ncomms13607. PubMed |
| The tumor suppressor FLCN mediates an alternate mTOR pathway to regulate browning of adipose tissue. Wada S, Neinast M, Jang C, Ibrahim YH, Lee G, Babu A, Li J, Hoshino A, Rowe GC, Rhee J, Martina JA, Puertollano R, Blenis J, Morley M, Baur JA, Seale P, Arany Z. Genes Dev. 2016 Nov 15;30(22):2551-2564. Epub 2016 Dec 2. PubMed |
Young adult born neurons enhance hippocampal dependent performance via influences on bilateral networks.
Zhuo JM, Tseng HA, Desai M, Bucklin ME, Mohammed AI, Robinson NT, Boyden ES, Rangel LM, Jasanoff AP, Gritton HJ, Han X.
Elife. 2016 Dec 3;5. pii: e22429. doi: 10.7554/eLife.22429.
PubMed
Associated Plasmids |
| Tuberous sclerosis complex inactivation disrupts melanogenesis via mTORC1 activation. Cao J, Tyburczy ME, Moss J, Darling TN, Widlund HR, Kwiatkowski DJ. J Clin Invest. 2017 Jan 3;127(1):349-364. doi: 10.1172/JCI84262. Epub 2016 Dec 5. PubMed |
| hMYH and hMTH1 cooperate for survival in mismatch repair defective T-cell acute lymphoblastic leukemia. Eshtad S, Mavajian Z, Rudd SG, Visnes T, Bostrom J, Altun M, Helleday T. Oncogenesis. 2016 Dec 5;5(12):e275. doi: 10.1038/oncsis.2016.72. PubMed |
| Acidic tumor microenvironment abrogates the efficacy of mTORC1 inhibitors. Faes S, Duval AP, Planche A, Uldry E, Santoro T, Pythoud C, Stehle JC, Horlbeck J, Letovanec I, Riggi N, Demartines N, Dormond O. Mol Cancer. 2016 Dec 5;15(1):78. PubMed |
| PET imaging-guided chemogenetic silencing reveals a critical role of primate rostromedial caudate in reward evaluation. Nagai Y, Kikuchi E, Lerchner W, Inoue KI, Ji B, Eldridge MA, Kaneko H, Kimura Y, Oh-Nishi A, Hori Y, Kato Y, Hirabayashi T, Fujimoto A, Kumata K, Zhang MR, Aoki I, Suhara T, Higuchi M, Takada M, Richmond BJ, Minamimoto T. Nat Commun. 2016 Dec 6;7:13605. doi: 10.1038/ncomms13605. PubMed |
| SFPQ*NONO and XLF function separately and together to promote DNA double-strand break repair via canonical nonhomologous end joining. Jaafar L, Li Z, Li S, Dynan WS. Nucleic Acids Res. 2016 Dec 6. pii: gkw1209. PubMed |
| EGF induces epithelial-mesenchymal transition and cancer stem-like cell properties in human oral cancer cells via promoting Warburg effect. Xu Q, Zhang Q, Ishida Y, Hajjar S, Tang X, Shi H, Dang CV, Le AD. Oncotarget. 2017 Feb 7;8(6):9557-9571. doi: 10.18632/oncotarget.13771. PubMed |
| Proteome-Scale Investigation of Protein Allosteric Regulation Perturbed by Somatic Mutations in 7,000 Cancer Genomes. Shen Q, Cheng F, Song H, Lu W, Zhao J, An X, Liu M, Chen G, Zhao Z, Zhang J. Am J Hum Genet. 2017 Jan 5;100(1):5-20. doi: 10.1016/j.ajhg.2016.09.020. Epub 2016 Dec 8. PubMed |
| Fyn kinase regulates translation in mammalian mitochondria. Koc EC, Miller-Lee JL, Koc H. Biochim Biophys Acta. 2017 Mar;1861(3):533-540. doi: 10.1016/j.bbagen.2016.12.004. Epub 2016 Dec 7. PubMed |
| Different Use of Cell Surface Glycosaminoglycans As Adherence Receptors to Corneal Cells by Gram Positive and Gram Negative Pathogens. Garcia B, Merayo-Lloves J, Rodriguez D, Alcalde I, Garcia-Suarez O, Alfonso JF, Baamonde B, Fernandez-Vega A, Vazquez F, Quiros LM. Front Cell Infect Microbiol. 2016 Nov 30;6:173. eCollection 2016. PubMed |
| CD63 regulates Epstein-Barr virus LMP1 exosomal packaging, enhancement of vesicle production, and non-canonical NF-kappaB signaling. Hurwitz SN, Nkosi D, Conlon MM, York SB, Liu X, Tremblay DC, Meckes DG Jr. J Virol. 2016 Dec 14. pii: JVI.02251-16. PubMed |
Perturb-Seq: Dissecting Molecular Circuits with Scalable Single-Cell RNA Profiling of Pooled Genetic Screens.
Dixit A, Parnas O, Li B, Chen J, Fulco CP, Jerby-Arnon L, Marjanovic ND, Dionne D, Burks T, Raychowdhury R, Adamson B, Norman TM, Lander ES, Weissman JS, Friedman N, Regev A.
Cell. 2016 Dec 15;167(7):1853-1866.e17. doi: 10.1016/j.cell.2016.11.038.
PubMed
Associated Plasmids |
| Caspase-2-mediated cell death is required for deleting aneuploid cells. Dawar S, Lim Y, Puccini J, White M, Thomas P, Bouchier-Hayes L, Green DR, Dorstyn L, Kumar S. Oncogene. 2016 Dec 19. doi: 10.1038/onc.2016.423. PubMed |
| Ras oncogene-independent activation of RALB signaling is a targetable mechanism of escape from NRAS(V12) oncogene addiction in acute myeloid leukemia. Pomeroy EJ, Lee LA, Lee RD, Schirm DK, Temiz NA, Ma J, Gruber TA, Diaz-Flores E, Moriarity BS, Downing JR, Shannon KM, Largaespada DA, Eckfeldt CE. Oncogene. 2016 Dec 19. doi: 10.1038/onc.2016.471. PubMed |
In vivo high-throughput profiling of CRISPR-Cpf1 activity.
Kim HK, Song M, Lee J, Menon AV, Jung S, Kang YM, Choi JW, Woo E, Koh HC, Nam JW, Kim H.
Nat Methods. 2016 Dec 19. doi: 10.1038/nmeth.4104.
PubMed
Associated Plasmids |
| A Photoactivatable Innate Immune Receptor for Optogenetic Inflammation. Moser BA, Esser-Kahn AP. ACS Chem Biol. 2016 Dec 29. doi: 10.1021/acschembio.6b01012. PubMed |
| Nuclear Localization of Integrin Cytoplasmic Associated Protein-1 Influences beta1 Integrin Activation and Recruits Krev/ Interaction Trapped-1 to the Nucleus. Draheim KM, Huet-Calderwood C, Simon B, Calderwood DA. J Biol Chem. 2016 Dec 21. pii: jbc.M116.762393. doi: 10.1074/jbc.M116.762393. PubMed |
| Metabolic Characterization of Intact Cells Reveals Intracellular Amyloid Beta but Not Its Precursor Protein to Reduce Mitochondrial Respiration. Schaefer PM, von Einem B, Walther P, Calzia E, von Arnim CA. PLoS One. 2016 Dec 22;11(12):e0168157. doi: 10.1371/journal.pone.0168157. eCollection 2016. PubMed |
| Zika virus infection induces mitosis abnormalities and apoptotic cell death of human neural progenitor cells. Souza BS, Sampaio GL, Pereira CS, Campos GS, Sardi SI, Freitas LA, Figueira CP, Paredes BD, Nonaka CK, Azevedo CM, Rocha VP, Bandeira AC, Mendez-Otero R, Dos Santos RR, Soares MB. Sci Rep. 2016 Dec 23;6:39775. doi: 10.1038/srep39775. PubMed |
| An enzymatic assay based on luciferase Ebola virus-like particles for evaluation of virolytic activity of antimicrobial peptides. Peskova M, Heger Z, Janda P, Adam V, Pekarik V. Peptides. 2016 Dec 22;88:87-96. doi: 10.1016/j.peptides.2016.12.015. PubMed |
| Prohibitin 2 Is an Inner Mitochondrial Membrane Mitophagy Receptor. Wei Y, Chiang WC, Sumpter R Jr, Mishra P, Levine B. Cell. 2017 Jan 12;168(1-2):224-238.e10. doi: 10.1016/j.cell.2016.11.042. Epub 2016 Dec 22. PubMed |
| Non-human Primate Schlafen11 Inhibits Production of Both Host and Viral Proteins. Stabell AC, Hawkins J, Li M, Gao X, David M, Press WH, Sawyer SL. PLoS Pathog. 2016 Dec 27;12(12):e1006066. doi: 10.1371/journal.ppat.1006066. eCollection 2016 Dec. PubMed |
| Proteins that interact with calgranulin B in the human colon cancer cell line HCT-116. Myung JK, Yeo SG, Kim KH, Baek KS, Shin D, Kim JH, Cho JY, Yoo BC. Oncotarget. 2017 Jan 24;8(4):6819-6832. doi: 10.18632/oncotarget.14301. PubMed |
Inhibition of CRISPR-Cas9 with Bacteriophage Proteins.
Rauch BJ, Silvis MR, Hultquist JF, Waters CS, McGregor MJ, Krogan NJ, Bondy-Denomy J.
Cell. 2016 Dec 22. pii: S0092-8674(16)31683-X. doi: 10.1016/j.cell.2016.12.009.
PubMed
Associated Plasmids |
| Nipbl Interacts with Zfp609 and the Integrator Complex to Regulate Cortical Neuron Migration. van den Berg DL, Azzarelli R, Oishi K, Martynoga B, Urban N, Dekkers DH, Demmers JA, Guillemot F. Neuron. 2016 Dec 20. pii: S0896-6273(16)30915-1. doi: 10.1016/j.neuron.2016.11.047. PubMed |
| Rational Design of Selective Allosteric Inhibitors of PHGDH and Serine Synthesis with Anti-tumor Activity. Wang Q, Liberti MV, Liu P, Deng X, Liu Y, Locasale JW, Lai L. Cell Chem Biol. 2016 Dec 20. pii: S2451-9456(16)30436-6. doi: 10.1016/j.chembiol.2016.11.013. PubMed |
| Cytosolic Fc receptor TRIM21 inhibits seeded tau aggregation. McEwan WA, Falcon B, Vaysburd M, Clift D, Oblak AL, Ghetti B, Goedert M, James LC. Proc Natl Acad Sci U S A. 2017 Jan 17;114(3):574-579. doi: 10.1073/pnas.1607215114. Epub 2017 Jan 3. PubMed |
| A screen for Fli-1 transcriptional modulators identifies PKC agonists that induce erythroid to megakaryocytic differentiation and suppress leukemogenesis. Liu T, Yao Y, Zhang G, Wang Y, Deng B, Song J, Li X, Han F, Xiao X, Yang J, Xia L, Li YJ, Plachynta M, Zhang M, Yan C, Mu S, Luo H, Zacksenhaus E, Hao X, Ben-David Y. Oncotarget. 2017 Mar 7;8(10):16728-16743. doi: 10.18632/oncotarget.14377. PubMed |
| Reprogramming Mouse Embryonic Fibroblasts with Transcription Factors to Induce a Hemogenic Program. Daniel MG, Pereira CF, Bernitz JM, Lemischka IR, Moore K. J Vis Exp. 2016 Dec 16;(118). doi: 10.3791/54372. PubMed |
| Annexin A8 promotes VEGF-A driven endothelial cell sprouting. Heitzig N, Brinkmann BF, Koerdt SN, Rosso G, Shahin V, Rescher U. Cell Adh Migr. 2017 Jan 6:1-13. doi: 10.1080/19336918.2016.1264559. PubMed |
| Oxidized nucleotide insertion by pol beta confounds ligation during base excision repair. Caglayan M, Horton JK, Dai DP, Stefanick DF, Wilson SH. Nat Commun. 2017 Jan 9;8:14045. doi: 10.1038/ncomms14045. PubMed |
| APC/C Dysfunction Limits Excessive Cancer Chromosomal Instability. Sansregret L, Patterson JO, Dewhurst S, Lopez-Garcia C, Koch A, McGranahan N, Chao WC, Barry DJ, Rowan A, Instrell R, Horswell S, Way M, Howell M, Singleton MR, Medema RH, Nurse P, Petronczki M, Swanton C. Cancer Discov. 2017 Jan 9. doi: 10.1158/2159-8290.CD-16-0645. PubMed |
| Highly Expandable Human iPS Cell-Derived Neural Progenitor Cells (NPC) and Neurons for Central Nervous System Disease Modeling and High-Throughput Screening. Cheng C, Fass DM, Folz-Donahue K, MacDonald ME, Haggarty SJ. Curr Protoc Hum Genet. 2017 Jan 11;92:21.8.1-21.8.21. doi: 10.1002/cphg.33. PubMed |
| Translation from unconventional 5' start sites drives tumour initiation. Sendoel A, Dunn JG, Rodriguez EH, Naik S, Gomez NC, Hurwitz B, Levorse J, Dill BD, Schramek D, Molina H, Weissman JS, Fuchs E. Nature. 2017 Jan 26;541(7638):494-499. doi: 10.1038/nature21036. Epub 2017 Jan 11. PubMed |
| Alternative lengthening of telomeres can be maintained by preferential elongation of lagging strands. Min J, Wright WE, Shay JW. Nucleic Acids Res. 2017 Mar 17;45(5):2615-2628. doi: 10.1093/nar/gkw1295. PubMed |
| The E3 ubiquitin ligase NEDD4 is an LC3-interactive protein and regulates autophagy. Sun A, Wei J, Childress C, Shaw JH 4th, Peng K, Shao G, Yang W, Lin Q. Autophagy. 2017 Mar 4;13(3):522-537. doi: 10.1080/15548627.2016.1268301. Epub 2017 Jan 13. PubMed |
| De-immunized and Functional Therapeutic (DeFT) versions of a long lasting recombinant alpha interferon for antiviral therapy. Mufarrege EF, Giorgetti S, Etcheverrigaray M, Terry F, Martin W, De Groot AS. Clin Immunol. 2017 Jan 10;176:31-41. doi: 10.1016/j.clim.2017.01.003. PubMed |
| Human AML-iPSCs Reacquire Leukemic Properties after Differentiation and Model Clonal Variation of Disease. Chao MP, Gentles AJ, Chatterjee S, Lan F, Reinisch A, Corces MR, Xavy S, Shen J, Haag D, Chanda S, Sinha R, Morganti RM, Nishimura T, Ameen M, Wu H, Wernig M, Wu JC, Majeti R. Cell Stem Cell. 2017 Mar 2;20(3):329-344.e7. doi: 10.1016/j.stem.2016.11.018. Epub 2017 Jan 12. PubMed |
| Glioblastoma Cancer Stem Cells Evade Innate Immune Suppression of Self-Renewal through Reduced TLR4 Expression. Alvarado AG, Thiagarajan PS, Mulkearns-Hubert EE, Silver DJ, Hale JS, Alban TJ, Turaga SM, Jarrar A, Reizes O, Longworth MS, Vogelbaum MA, Lathia JD. Cell Stem Cell. 2017 Apr 6;20(4):450-461.e4. doi: 10.1016/j.stem.2016.12.001. Epub 2017 Jan 12. PubMed |
| Systematic evaluation of markers used for the identification of human induced pluripotent stem cells. Bharathan SP, Manian KV, Aalam SM, Palani D, Deshpande PA, Pratheesh MD, Srivastava A, Velayudhan SR. Biol Open. 2017 Jan 15;6(1):100-108. doi: 10.1242/bio.022111. PubMed |
| JunB regulates angiogenesis and neurovascular parallel alignment in mouse embryonic skin. Yoshitomi Y, Ikeda T, Saito H, Yoshitake Y, Ishigaki Y, Hatta T, Kato N, Yonekura H. J Cell Sci. 2017 Mar 1;130(5):916-926. doi: 10.1242/jcs.196303. Epub 2017 Jan 17. PubMed |
| Dopamine promotes NMDA receptor hypofunction in the retina through D1 receptor-mediated Csk activation, Src inhibition and decrease of GluN2B phosphorylation. Socodato R, Santiago FN, Portugal CC, Domith I, Encarnacao TG, Loiola EC, Ventura AL, Cossenza M, Relvas JB, Castro NG, Paes-de-Carvalho R. Sci Rep. 2017 Jan 18;7:40912. doi: 10.1038/srep40912. PubMed |
Pooled CRISPR screening with single-cell transcriptome readout.
Datlinger P, Rendeiro AF, Schmidl C, Krausgruber T, Traxler P, Klughammer J, Schuster LC, Kuchler A, Alpar D, Bock C.
Nat Methods. 2017 Jan 18. doi: 10.1038/nmeth.4177.
PubMed
Associated Plasmids |
| TRIM8 regulates stemness in glioblastoma through PIAS3-STAT3. Zhang C, Mukherjee S, Tucker-Burden C, Ross JL, Chau MJ, Kong J, Brat DJ. Mol Oncol. 2017 Mar;11(3):280-294. doi: 10.1002/1878-0261.12034. Epub 2017 Feb 15. PubMed |
| Lysosome-Dependent Activation of Human Dendritic Cells by the Vaccine Adjuvant QS-21. Welsby I, Detienne S, N'Kuli F, Thomas S, Wouters S, Bechtold V, De Wit D, Gineste R, Reinheckel T, Elouahabi A, Courtoy PJ, Didierlaurent AM, Goriely S. Front Immunol. 2017 Jan 5;7:663. doi: 10.3389/fimmu.2016.00663. eCollection 2016. PubMed |
| Psoriasin has divergent effects on the innate immune responses of murine glial cells. Jansen S, Kress E, Fragoulis A, Wruck CJ, Wolf R, Grotzinger J, Michalek M, Pufe T, Tauber SC, Brandenburg LO. J Neurochem. 2017 Apr;141(1):86-99. doi: 10.1111/jnc.13959. Epub 2017 Feb 27. PubMed |
An Argonaute phosphorylation cycle promotes microRNA-mediated silencing.
Golden RJ, Chen B, Li T, Braun J, Manjunath H, Chen X, Wu J, Schmid V, Chang TC, Kopp F, Ramirez-Martinez A, Tagliabracci VS, Chen ZJ, Xie Y, Mendell JT.
Nature. 2017 Feb 9;542(7640):197-202. doi: 10.1038/nature21025. Epub 2017 Jan 23.
PubMed
Associated Plasmids |
| Interaction with ZMYND11 mediates opposing roles of Ras-responsive transcription factors ETS1 and ETS2. Plotnik JP, Hollenhorst PC. Nucleic Acids Res. 2017 May 5;45(8):4452-4462. doi: 10.1093/nar/gkx039. PubMed |
| Nectin-like 4 Complexes with Choline Transporter-like Protein-1 and Regulates Schwann Cell Choline Homeostasis and Lipid Biogenesis in Vitro. Heffernan C, Jain MR, Liu T, Kim H, Barretto K, Li H, Maurel P. J Biol Chem. 2017 Mar 17;292(11):4484-4498. doi: 10.1074/jbc.M116.747816. Epub 2017 Jan 24. PubMed |
| Physiologic and genetic evidence links hemopexin to triglycerides in mice and humans. Lawson HA, Zayed M, Wayhart JP, Fabbrini E, Love-Gregory L, Klein S, Semenkovich CF. Int J Obes (Lond). 2017 Apr;41(4):631-638. doi: 10.1038/ijo.2017.19. Epub 2017 Jan 25. PubMed |
| The Genetic Basis of Hepatosplenic T-cell Lymphoma. McKinney M, Moffitt AB, Gaulard P, Travert M, De Leval L, Nicolae A, Raffeld M, Jaffe ES, Pittaluga S, Xi L, Heavican T, Iqbal J, Belhadj K, Delfau-Larue MH, Fataccioli V, Czader MB, Lossos IS, Chapman-Fredricks JR, Richards KL, Fedoriw Y, Ondrejka SL, Hsi ED, Low L, Weisenburger D, Chan WC, Mehta-Shah N, Horwitz S, Bernal-Mizrachi L, Flowers CR, Beaven AW, Parihar M, Baseggio L, Parrens M, Moreau A, Sujobert P, Pilichowska M, Evens AM, Chadburn A, Au-Yeung RK, Srivastava G, Choi WW, Goodlad JR, Aurer I, Basic-Kinda S, Gascoyne RD, Davis NS, Li G, Zhang J, Rajagopalan D, Reddy A, Love C, Levy S, Zhuang Y, Datta J, Dunson DB, Dave SS. Cancer Discov. 2017 Apr;7(4):369-379. doi: 10.1158/2159-8290.CD-16-0330. Epub 2017 Jan 25. PubMed |
| Interspecies Chimerism with Mammalian Pluripotent Stem Cells. Wu J, Platero-Luengo A, Sakurai M, Sugawara A, Gil MA, Yamauchi T, Suzuki K, Bogliotti YS, Cuello C, Morales Valencia M, Okumura D, Luo J, Vilarino M, Parrilla I, Soto DA, Martinez CA, Hishida T, Sanchez-Bautista S, Martinez-Martinez ML, Wang H, Nohalez A, Aizawa E, Martinez-Redondo P, Ocampo A, Reddy P, Roca J, Maga EA, Esteban CR, Berggren WT, Nunez Delicado E, Lajara J, Guillen I, Guillen P, Campistol JM, Martinez EA, Ross PJ, Izpisua Belmonte JC. Cell. 2017 Jan 26;168(3):473-486.e15. doi: 10.1016/j.cell.2016.12.036. PubMed |
| Mutations in tropomyosin 4 underlie a rare form of human macrothrombocytopenia. Pleines I, Woods J, Chappaz S, Kew V, Foad N, Ballester-Beltran J, Aurbach K, Lincetto C, Lane RM, Schevzov G, Alexander WS, Hilton DJ, Astle WJ, Downes K, Nurden P, Westbury SK, Mumford AD, Obaji SG, Collins PW, Delerue F, Ittner LM, Bryce NS, Holliday M, Lucas CA, Hardeman EC, Ouwehand WH, Gunning PW, Turro E, Tijssen MR, Kile BT. J Clin Invest. 2017 Mar 1;127(3):814-829. doi: 10.1172/JCI86154. Epub 2017 Jan 30. PubMed |
| Mouse Stbd1 is N-myristoylated and affects ER-mitochondria association and mitochondrial morphology. Demetriadou A, Morales-Sanfrutos J, Nearchou M, Baba O, Kyriacou K, Tate EW, Drousiotou A, Petrou PP. J Cell Sci. 2017 Mar 1;130(5):903-915. doi: 10.1242/jcs.195263. Epub 2017 Jan 30. PubMed |
| Visualization of aging-associated chromatin alterations with an engineered TALE system. Ren R, Deng L, Xue Y, Suzuki K, Zhang W, Yu Y, Wu J, Sun L, Gong X, Luan H, Yang F, Ju Z, Ren X, Wang S, Tang H, Geng L, Zhang W, Li J, Qiao J, Xu T, Qu J, Liu GH. Cell Res. 2017 Apr;27(4):483-504. doi: 10.1038/cr.2017.18. Epub 2017 Jan 31. PubMed |
| Metalloprotease-disintegrin ADAM12 actively promotes the stem cell-like phenotype in claudin-low breast cancer. Duhachek-Muggy S, Qi Y, Wise R, Alyahya L, Li H, Hodge J, Zolkiewska A. Mol Cancer. 2017 Feb 1;16(1):32. doi: 10.1186/s12943-017-0599-6. PubMed |
| Genome Editing Reveals Glioblastoma Addiction to MicroRNA-10b. El Fatimy R, Subramanian S, Uhlmann EJ, Krichevsky AM. Mol Ther. 2017 Feb 1;25(2):368-378. doi: 10.1016/j.ymthe.2016.11.004. PubMed |
Dnmt3a restrains mast cell inflammatory responses.
Leoni C, Montagner S, Rinaldi A, Bertoni F, Polletti S, Balestrieri C, Monticelli S.
Proc Natl Acad Sci U S A. 2017 Feb 6. pii: 201616420. doi: 10.1073/pnas.1616420114.
PubMed
Associated Plasmids |
| Epigenetic regulation of HDAC1 SUMOylation as an endogenous neuroprotection against Abeta toxicity in a mouse model of Alzheimer's disease. Tao CC, Hsu WL, Ma YL, Cheng SJ, Lee EH. Cell Death Differ. 2017 Apr;24(4):597-614. doi: 10.1038/cdd.2016.161. Epub 2017 Feb 10. PubMed |
| Diet-induced obesity links to ER positive breast cancer progression via LPA/PKD-1-CD36 signaling-mediated microvascular remodeling. Dong L, Yuan Y, Opansky C, Chen Y, Aguilera-Barrantes I, Wu S, Yuan R, Cao Q, Cheng YC, Sahoo D, Silverstein RL, Ren B. Oncotarget. 2017 Apr 4;8(14):22550-22562. doi: 10.18632/oncotarget.15123. PubMed |
| E3 ubiquitin ligase Pirh2 enhances tumorigenic properties of human non-small cell lung carcinoma cells. Daks A, Petukhov A, Fedorova O, Shuvalov O, Merkulov V, Vasileva E, Antonov A, Barlev NA. Genes Cancer. 2016 Nov;7(11-12):383-393. doi: 10.18632/genesandcancer.123. PubMed |
| Inhibition of serotonin receptor type 1 in acute myeloid leukemia impairs leukemia stem cell functionality: a promising novel therapeutic target. Etxabe A, Lara-Castillo MC, Cornet-Masana JM, Banus-Mulet A, Nomdedeu M, Torrente MA, Pratcorona M, Diaz-Beya M, Esteve J, Risueno RM. Leukemia. 2017 Nov;31(11):2288-2302. doi: 10.1038/leu.2017.52. Epub 2017 Feb 14. PubMed |
| Method for Dual Viral Vector Mediated CRISPR-Cas9 Gene Disruption in Primary Human Endothelial Cells. Gong H, Liu M, Klomp J, Merrill BJ, Rehman J, Malik AB. Sci Rep. 2017 Feb 15;7:42127. doi: 10.1038/srep42127. PubMed |
| Jerantinine A induces tumor-specific cell death through modulation of splicing factor 3b subunit 1 (SF3B1). Chung FF, Tan PF, Raja VJ, Tan BS, Lim KH, Kam TS, Hii LW, Tan SH, See SJ, Tan YF, Wong LZ, Yam WK, Mai CW, Bradshaw TD, Leong CO. Sci Rep. 2017 Feb 15;7:42504. doi: 10.1038/srep42504. PubMed |
| HOXC8 regulates self-renewal, differentiation and transformation of breast cancer stem cells. Shah M, Cardenas R, Wang B, Persson J, Mongan NP, Grabowska A, Allegrucci C. Mol Cancer. 2017 Feb 16;16(1):38. doi: 10.1186/s12943-017-0605-z. PubMed |
| Restriction of Human Cytomegalovirus Replication by ISG15, a Host Effector Regulated by cGAS-STING Double-Stranded-DNA Sensing. Bianco C, Mohr I. J Virol. 2017 Apr 13;91(9). pii: JVI.02483-16. doi: 10.1128/JVI.02483-16. Print 2017 May 1. PubMed |
| Expression level is a key determinant of E2F1-mediated cell fate. Shats I, Deng M, Davidovich A, Zhang C, Kwon JS, Manandhar D, Gordan R, Yao G, You L. Cell Death Differ. 2017 Apr;24(4):626-637. doi: 10.1038/cdd.2017.12. Epub 2017 Feb 17. PubMed |
| The CRISPR/Cas9 system efficiently reverts the tumorigenic ability of BCR/ABL in vitro and in a xenograft model of chronic myeloid leukemia. Garcia-Tunon I, Hernandez-Sanchez M, Ordonez JL, Alonso-Perez V, Alamo-Quijada M, Benito R, Guerrero C, Hernandez-Rivas JM, Sanchez-Martin M. Oncotarget. 2017 Apr 18;8(16):26027-26040. doi: 10.18632/oncotarget.15215. PubMed |
| Mitochondrial damage elicits a TCDD-inducible poly(ADP-ribose) polymerase-mediated antiviral response. Kozaki T, Komano J, Kanbayashi D, Takahama M, Misawa T, Satoh T, Takeuchi O, Kawai T, Shimizu S, Matsuura Y, Akira S, Saitoh T. Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):2681-2686. doi: 10.1073/pnas.1621508114. Epub 2017 Feb 17. PubMed |
| Enhancement of beta-Globin Gene Expression in Thalassemic IVS2-654 Induced Pluripotent Stem Cell-Derived Erythroid Cells by Modified U7 snRNA. Phanthong P, Borwornpinyo S, Kitiyanant N, Jearawiriyapaisarn N, Nuntakarn L, Saetan J, Nualkaew T, Sa-Ngiamsuntorn K, Anurathapan U, Dinnyes A, Kitiyanant Y, Hongeng S. Stem Cells Transl Med. 2017 Apr;6(4):1059-1069. doi: 10.1002/sctm.16-0121. Epub 2017 Feb 18. PubMed |
| MELK expression in ovarian cancer correlates with poor outcome and its inhibition by OTSSP167 abrogates proliferation and viability of ovarian cancer cells. Kohler RS, Kettelhack H, Knipprath-Meszaros AM, Fedier A, Schoetzau A, Jacob F, Heinzelmann-Schwarz V. Gynecol Oncol. 2017 Apr;145(1):159-166. doi: 10.1016/j.ygyno.2017.02.016. Epub 2017 Feb 14. PubMed |
| Critical threshold levels of DNA methyltransferase 1 are required to maintain DNA methylation across the genome in human cancer cells. Cai Y, Tsai HC, Yen RC, Zhang YW, Kong X, Wang W, Xia L, Baylin SB. Genome Res. 2017 Apr;27(4):533-544. doi: 10.1101/gr.208108.116. Epub 2017 Feb 23. PubMed |
| Hyperglycemia-Induced Changes in ZIP7 and ZnT7 Expression Cause Zn2+ Release From the Sarco(endo)plasmic Reticulum and Mediate ER Stress in the Heart. Tuncay E, Bitirim VC, Durak A, Carrat GRJ, Taylor KM, Rutter GA, Turan B. Diabetes. 2017 May;66(5):1346-1358. doi: 10.2337/db16-1099. Epub 2017 Feb 23. PubMed |
| Upregulation of CD147 Promotes Metastasis of Cholangiocarcinoma by Modulating the Epithelial-to-Mesenchymal Transitional Process. Dana P, Kariya R, Vaeteewoottacharn K, Sawanyawisuth K, Seubwai W, Matsuda K, Okada S, Wongkham S. Oncol Res. 2017 Aug 7;25(7):1047-1059. doi: 10.3727/096504016X14813899000565. Epub 2016 Dec 15. PubMed |
| YOD1/TRAF6 association balances p62-dependent IL-1 signaling to NF-kappaB. Schimmack G, Schorpp K, Kutzner K, Gehring T, Brenke JK, Hadian K, Krappmann D. Elife. 2017 Feb 28;6. pii: e22416. doi: 10.7554/eLife.22416. PubMed |
| A Comprehensive TALEN-Based Knockout Library for Generating Human-Induced Pluripotent Stem Cell-Based Models for Cardiovascular Diseases. Karakikes I, Termglinchan V, Cepeda DA, Lee J, Diecke S, Hendel A, Itzhaki I, Ameen M, Shrestha R, Wu H, Ma N, Shao NY, Seeger T, Woo N, Wilson KD, Matsa E, Porteus MH, Sebastiano V, Wu JC. Circ Res. 2017 May 12;120(10):1561-1571. doi: 10.1161/CIRCRESAHA.116.309948. Epub 2017 Feb 28. PubMed |
Rapid and efficient generation of oligodendrocytes from human induced pluripotent stem cells using transcription factors.
Ehrlich M, Mozafari S, Glatza M, Starost L, Velychko S, Hallmann AL, Cui QL, Schambach A, Kim KP, Bachelin C, Marteyn A, Hargus G, Johnson RM, Antel J, Sterneckert J, Zaehres H, Scholer HR, Baron-Van Evercooren A, Kuhlmann T.
Proc Natl Acad Sci U S A. 2017 Mar 14;114(11):E2243-E2252. doi: 10.1073/pnas.1614412114. Epub 2017 Feb 28.
PubMed
Associated Plasmids |
| Linking of mPGES-1 and iNOS activates stem-like phenotype in EGFR-driven epithelial tumor cells. Terzuoli E, Finetti F, Costanza F, Giachetti A, Ziche M, Donnini S. Nitric Oxide. 2017 Jun 1;66:17-29. doi: 10.1016/j.niox.2017.02.010. Epub 2017 Mar 1. PubMed |
| Reactive Oxygen Species-Mediated Loss of Synaptic Akt1 Signaling Leads to Deficient Activity-Dependent Protein Translation Early in Alzheimer's Disease. Ahmad F, Singh K, Das D, Gowaikar R, Shaw E, Ramachandran A, Rupanagudi KV, Kommaddi RP, Bennett DA, Ravindranath V. Antioxid Redox Signal. 2017 Apr 12. doi: 10.1089/ars.2016.6860. PubMed |
| Focal Adhesion Kinase as a Potential Target in AML and MDS. Carter BZ, Mak PY, Wang X, Yang H, Garcia-Manero G, Mak DH, Mu H, Ruvolo VR, Qiu Y, Coombes K, Zhang N, Ragon B, Weaver DT, Pachter JA, Kornblau S, Andreeff M. Mol Cancer Ther. 2017 Jun;16(6):1133-1144. doi: 10.1158/1535-7163.MCT-16-0719. Epub 2017 Mar 7. PubMed |
| Integrin-beta4 identifies cancer stem cell-enriched populations of partially mesenchymal carcinoma cells. Bierie B, Pierce SE, Kroeger C, Stover DG, Pattabiraman DR, Thiru P, Liu Donaher J, Reinhardt F, Chaffer CL, Keckesova Z, Weinberg RA. Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):E2337-E2346. doi: 10.1073/pnas.1618298114. Epub 2017 Mar 7. PubMed |
| The Novel Toll-Like Receptor 2 Agonist SUP3 Enhances Antigen Presentation and T Cell Activation by Dendritic Cells. Guo X, Wu N, Shang Y, Liu X, Wu T, Zhou Y, Liu X, Huang J, Liao X, Wu L. Front Immunol. 2017 Feb 21;8:158. doi: 10.3389/fimmu.2017.00158. eCollection 2017. PubMed |
| Reconstituting development of pancreatic intraepithelial neoplasia from primary human pancreas duct cells. Lee J, Snyder ER, Liu Y, Gu X, Wang J, Flowers BM, Kim YJ, Park S, Szot GL, Hruban RH, Longacre TA, Kim SK. Nat Commun. 2017 Mar 8;8:14686. doi: 10.1038/ncomms14686. PubMed |
DUX4-induced dsRNA and MYC mRNA stabilization activate apoptotic pathways in human cell models of facioscapulohumeral dystrophy.
Shadle SC, Zhong JW, Campbell AE, Conerly ML, Jagannathan S, Wong CJ, Morello TD, van der Maarel SM, Tapscott SJ.
PLoS Genet. 2017 Mar 8;13(3):e1006658. doi: 10.1371/journal.pgen.1006658. eCollection 2017 Mar.
PubMed
Associated Plasmids |
| PPAR-alpha Activation Mediates Innate Host Defense through Induction of TFEB and Lipid Catabolism. Kim YS, Lee HM, Kim JK, Yang CS, Kim TS, Jung M, Jin HS, Kim S, Jang J, Oh GT, Kim JM, Jo EK. J Immunol. 2017 Apr 15;198(8):3283-3295. doi: 10.4049/jimmunol.1601920. Epub 2017 Mar 8. PubMed |
| GARLH Family Proteins Stabilize GABAA Receptors at Synapses. Yamasaki T, Hoyos-Ramirez E, Martenson JS, Morimoto-Tomita M, Tomita S. Neuron. 2017 Mar 8;93(5):1138-1152.e6. doi: 10.1016/j.neuron.2017.02.023. PubMed |
| CRISPR-Cas9 system-driven site-specific selection pressure on Herpes simplex virus genomes. Li Z, Bi Y, Xiao H, Sun L, Ren Y, Li Y, Chen C, Cun W. Virus Res. 2017 Mar 6. pii: S0168-1702(16)30694-3. doi: 10.1016/j.virusres.2017.03.010. PubMed |
| Depletion of oxaloacetate decarboxylase FAHD1 inhibits mitochondrial electron transport and induces cellular senescence in human endothelial cells. Petit M, Koziel R, Etemad S, Pircher H, Jansen-Durr P. Exp Gerontol. 2017 Jun;92:7-12. doi: 10.1016/j.exger.2017.03.004. Epub 2017 Mar 8. PubMed |
Optogenetic control with a photocleavable protein, PhoCl.
Zhang W, Lohman AW, Zhuravlova Y, Lu X, Wiens MD, Hoi H, Yaganoglu S, Mohr MA, Kitova EN, Klassen JS, Pantazis P, Thompson RJ, Campbell RE.
Nat Methods. 2017 Mar 13. doi: 10.1038/nmeth.4222.
PubMed
Associated Plasmids |
| Reduction of Ether-Type Glycerophospholipids, Plasmalogens, by NF-kappaB Signal Leading to Microglial Activation. Hossain MS, Abe Y, Ali F, Youssef M, Honsho M, Fujiki Y, Katafuchi T. J Neurosci. 2017 Apr 12;37(15):4074-4092. doi: 10.1523/JNEUROSCI.3941-15.2017. Epub 2017 Mar 14. PubMed |
| PSMA redirects cell survival signaling from the MAPK to the PI3K-AKT pathways to promote the progression of prostate cancer. Caromile LA, Dortche K, Rahman MM, Grant CL, Stoddard C, Ferrer FA, Shapiro LH. Sci Signal. 2017 Mar 14;10(470). pii: 10/470/eaag3326. doi: 10.1126/scisignal.aag3326. PubMed |
| ORAI2 modulates store-operated calcium entry and T cell-mediated immunity. Vaeth M, Yang J, Yamashita M, Zee I, Eckstein M, Knosp C, Kaufmann U, Karoly Jani P, Lacruz RS, Flockerzi V, Kacskovics I, Prakriya M, Feske S. Nat Commun. 2017 Mar 15;8:14714. doi: 10.1038/ncomms14714. PubMed |
DND1 maintains germline stem cells via recruitment of the CCR4-NOT complex to target mRNAs.
Yamaji M, Jishage M, Meyer C, Suryawanshi H, Der E, Yamaji M, Garzia A, Morozov P, Manickavel S, McFarland HL, Roeder RG, Hafner M, Tuschl T.
Nature. 2017 Mar 23;543(7646):568-572. doi: 10.1038/nature21690. Epub 2017 Mar 15.
PubMed
Associated Plasmids |
| Quantifying 3D chemotaxis in microfluidic-based chips with step gradients of collagen hydrogel concentrations. Del Amo C, Borau C, Movilla N, Asin J, Garcia-Aznar JM. Integr Biol (Camb). 2017 Apr 18;9(4):339-349. doi: 10.1039/c7ib00022g. PubMed |
| Tumor Suppressor PTPRJ Is a Target of miR-155 in Colorectal Cancer. Zhang XF, Tu R, Li K, Ye P, Cui X. J Cell Biochem. 2017 Mar 18. doi: 10.1002/jcb.25995. PubMed |
| Silencing of the small GTPase DIRAS3 induces cellular senescence in human white adipose stromal/progenitor cells. Ejaz A, Mattesich M, Zwerschke W. Aging (Albany NY). 2017 Mar 17;9(3):860-879. doi: 10.18632/aging.101197. PubMed |
| Transcription factor NF-kappa B represses ANT1 transcription and leads to mitochondrial dysfunctions. Zhang C, Jiang H, Wang P, Liu H, Sun X. Sci Rep. 2017 Mar 20;7:44708. doi: 10.1038/srep44708. PubMed |
| Combinatorial CRISPR-Cas9 screens for de novo mapping of genetic interactions. Shen JP, Zhao D, Sasik R, Luebeck J, Birmingham A, Bojorquez-Gomez A, Licon K, Klepper K, Pekin D, Beckett AN, Sanchez KS, Thomas A, Kuo CC, Du D, Roguev A, Lewis NE, Chang AN, Kreisberg JF, Krogan N, Qi L, Ideker T, Mali P. Nat Methods. 2017 Jun;14(6):573-576. doi: 10.1038/nmeth.4225. Epub 2017 Mar 20. PubMed |
| Hepatocyte nuclear factor 1alpha downregulates HBV gene expression and replication by activating the NF-kappaB signaling pathway. Lin J, Gu C, Shen Z, Liu Y, Wang W, Tao S, Cui X, Liu J, Xie Y. PLoS One. 2017 Mar 20;12(3):e0174017. doi: 10.1371/journal.pone.0174017. eCollection 2017. PubMed |
| The H3K27 demethylase, Utx, regulates adipogenesis in a differentiation stage-dependent manner. Ota K, Tong KI, Goto K, Tomida S, Komuro A, Wang Z, Nishio K, Okada H. PLoS One. 2017 Mar 20;12(3):e0173713. doi: 10.1371/journal.pone.0173713. eCollection 2017. PubMed |
| Using Protein-Fragment Complementation Assays (PCA) and Peptide Arrays to Study Telomeric Protein-Protein Interactions. Ma W, Lee OH, Kim H, Songyang Z. Methods Mol Biol. 2017;1587:147-160. doi: 10.1007/978-1-4939-6892-3_15. PubMed |
| Bovine trophectoderm cells induced from bovine fibroblasts with induced pluripotent stem cell reprogramming factors. Talbot NC, Sparks WO, Phillips CE, Ealy AD, Powell AM, Caperna TJ, Garrett WM, Donovan DM, Blomberg LA. Mol Reprod Dev. 2017 Jun;84(6):468-485. doi: 10.1002/mrd.22797. Epub 2017 Apr 12. PubMed |
Genome-scale CRISPR-Cas9 knockout and transcriptional activation screening.
Joung J, Konermann S, Gootenberg JS, Abudayyeh OO, Platt RJ, Brigham MD, Sanjana NE, Zhang F.
Nat Protoc. 2017 Apr;12(4):828-863. doi: 10.1038/nprot.2017.016. Epub 2017 Mar 23.
PubMed
Associated Plasmids |
| Geometry-dependent functional changes in iPSC-derived cardiomyocytes probed by functional imaging and RNA sequencing. Werley CA, Chien MP, Gaublomme J, Shekhar K, Butty V, Yi BA, Kralj JM, Bloxham W, Boyer LA, Regev A, Cohen AE. PLoS One. 2017 Mar 23;12(3):e0172671. doi: 10.1371/journal.pone.0172671. eCollection 2017. PubMed |
| Requirement of cytosolic phospholipase A2 gamma in lipid droplet formation. Su X, Liu S, Zhang X, Lam SM, Hu X, Zhou Y, Chen J, Wang Y, Wu C, Shui G, Lu M, Pei R, Chen X. Biochim Biophys Acta. 2017 Jul;1862(7):692-705. doi: 10.1016/j.bbalip.2017.03.007. Epub 2017 Mar 21. PubMed |
A DNA-Based T Cell Receptor Reveals a Role for Receptor Clustering in Ligand Discrimination.
Taylor MJ, Husain K, Gartner ZJ, Mayor S, Vale RD.
Cell. 2017 Mar 23;169(1):108-119.e20. doi: 10.1016/j.cell.2017.03.006.
PubMed
Associated Plasmids |
| Polo-like kinase 1 expression is suppressed by CCAAT/enhancer-binding protein alpha to mediate colon carcinoma cell differentiation and apoptosis. Dasgupta N, Thakur BK, Ta A, Das S, Banik G, Das S. Biochim Biophys Acta. 2017 Jul;1861(7):1777-1787. doi: 10.1016/j.bbagen.2017.03.015. Epub 2017 Mar 21. PubMed |
NRAS destines tumor cells to the lungs.
Giannou AD, Marazioti A, Kanellakis NI, Giopanou I, Lilis I, Zazara DE, Ntaliarda G, Kati D, Armenis V, Giotopoulou GA, Krontira AC, Lianou M, Agalioti T, Vreka M, Papageorgopoulou M, Fouzas S, Kardamakis D, Psallidas I, Spella M, Stathopoulos GT.
EMBO Mol Med. 2017 May;9(5):672-686. doi: 10.15252/emmm.201606978.
PubMed
Associated Plasmids |
| Reporter Systems to Study HTLV-1 Transmission. Gross C, Thoma-Kress AK. Methods Mol Biol. 2017;1582:33-46. doi: 10.1007/978-1-4939-6872-5_3. PubMed |
| Analyzing trapped protein complexes by Virotrap and SFINX. Titeca K, Van Quickelberghe E, Samyn N, De Sutter D, Verhee A, Gevaert K, Tavernier J, Eyckerman S. Nat Protoc. 2017 May;12(5):881-898. doi: 10.1038/nprot.2017.014. Epub 2017 Mar 30. PubMed |
| Sedentary lifestyle related exosomal release of Hotair from gluteal-femoral fat promotes intestinal cell proliferation. Lu X, Bai D, Liu X, Zhou C, Yang G. Sci Rep. 2017 Mar 31;7:45648. doi: 10.1038/srep45648. PubMed |
CRISPR-Cas9 epigenome editing enables high-throughput screening for functional regulatory elements in the human genome.
Klann TS, Black JB, Chellappan M, Safi A, Song L, Hilton IB, Crawford GE, Reddy TE, Gersbach CA.
Nat Biotechnol. 2017 Apr 3. doi: 10.1038/nbt.3853.
PubMed
Associated Plasmids |
| FKBP65-dependent peptidyl-prolyl isomerase activity potentiates the lysyl hydroxylase 2-driven collagen cross-link switch. Chen Y, Terajima M, Banerjee P, Guo H, Liu X, Yu J, Yamauchi M, Kurie JM. Sci Rep. 2017 Apr 5;7:46021. doi: 10.1038/srep46021. PubMed |
| Mutation of the Human Circadian Clock Gene CRY1 in Familial Delayed Sleep Phase Disorder. Patke A, Murphy PJ, Onat OE, Krieger AC, Ozcelik T, Campbell SS, Young MW. Cell. 2017 Apr 6;169(2):203-215.e13. doi: 10.1016/j.cell.2017.03.027. PubMed |
| Pyroptosis and Apoptosis Pathways Engage in Bidirectional Crosstalk in Monocytes and Macrophages. Taabazuing CY, Okondo MC, Bachovchin DA. Cell Chem Biol. 2017 Apr 20;24(4):507-514.e4. doi: 10.1016/j.chembiol.2017.03.009. Epub 2017 Apr 6. PubMed |
| Crystal structure of Zen4 in the apo state reveals a missing conformation of kinesin. Guan R, Zhang L, Su QP, Mickolajczyk KJ, Chen GY, Hancock WO, Sun Y, Zhao Y, Chen Z. Nat Commun. 2017 Apr 10;8:14951. doi: 10.1038/ncomms14951. PubMed |
| Regulation of spindle integrity and mitotic fidelity by BCCIP. Huhn SC, Liu J, Ye C, Lu H, Jiang X, Feng X, Ganesan S, White E, Shen Z. Oncogene. 2017 Aug 17;36(33):4750-4766. doi: 10.1038/onc.2017.92. Epub 2017 Apr 10. PubMed |
| GP73 represses host innate immune response to promote virus replication by facilitating MAVS and TRAF6 degradation. Zhang X, Zhu C, Wang T, Jiang H, Ren Y, Zhang Q, Wu K, Liu F, Liu Y, Wu J. PLoS Pathog. 2017 Apr 10;13(4):e1006321. doi: 10.1371/journal.ppat.1006321. eCollection 2017 Apr. PubMed |
| Generation of an induced pluripotent stem cell line that mimics the disease phenotypes from a patient with Fanconi anemia by conditional complementation. Bharathan SP, Nandy K, Palani D, Janet A NB, Natarajan K, George B, Srivastava A, Velayudhan SR. Stem Cell Res. 2017 Apr;20:54-57. doi: 10.1016/j.scr.2017.02.006. Epub 2017 Feb 22. PubMed |
| In Vivo Enrichment of Diabetogenic T Cells. Thelin MA, Kissler S, Vigneault F, Watters AL, White D, Koshy ST, Vermillion SA, Mooney DJ, Serwold T, Ali OA. Diabetes. 2017 Aug;66(8):2220-2229. doi: 10.2337/db16-0946. Epub 2017 Apr 10. PubMed |
| Induction of functional dopamine neurons from human astrocytes in vitro and mouse astrocytes in a Parkinson's disease model. Rivetti di Val Cervo P, Romanov RA, Spigolon G, Masini D, Martin-Montanez E, Toledo EM, La Manno G, Feyder M, Pifl C, Ng YH, Sanchez SP, Linnarsson S, Wernig M, Harkany T, Fisone G, Arenas E. Nat Biotechnol. 2017 May;35(5):444-452. doi: 10.1038/nbt.3835. Epub 2017 Apr 10. PubMed |
| Hoxa9 and Meis1 Cooperatively Induce Addiction to Syk Signaling by Suppressing miR-146a in Acute Myeloid Leukemia. Mohr S, Doebele C, Comoglio F, Berg T, Beck J, Bohnenberger H, Alexe G, Corso J, Strobel P, Wachter A, Beissbarth T, Schnutgen F, Cremer A, Haetscher N, Gollner S, Rouhi A, Palmqvist L, Rieger MA, Schroeder T, Bonig H, Muller-Tidow C, Kuchenbauer F, Schutz E, Green AR, Urlaub H, Stegmaier K, Humphries RK, Serve H, Oellerich T. Cancer Cell. 2017 Apr 10;31(4):549-562.e11. doi: 10.1016/j.ccell.2017.03.001. PubMed |
| Nucleotide-binding oligomerization domain (NOD) signaling defects and cell death susceptibility cannot be uncoupled in X-linked inhibitor of apoptosis (XIAP)-driven inflammatory disease. Chirieleison SM, Marsh RA, Kumar P, Rathkey JK, Dubyak GR, Abbott DW. J Biol Chem. 2017 Jun 9;292(23):9666-9679. doi: 10.1074/jbc.M117.781500. Epub 2017 Apr 12. PubMed |
| Epithelial-Mesenchymal Micro-niches Govern Stem Cell Lineage Choices. Yang H, Adam RC, Ge Y, Hua ZL, Fuchs E. Cell. 2017 Apr 20;169(3):483-496.e13. doi: 10.1016/j.cell.2017.03.038. Epub 2017 Apr 13. PubMed |
| Synthesis and Degradation of Adenosine 5'-Tetraphosphate by Nicotinamide and Nicotinate Phosphoribosyltransferases. Amici A, Grolla AA, Del Grosso E, Bellini R, Bianchi M, Travelli C, Garavaglia S, Sorci L, Raffaelli N, Ruggieri S, Genazzani AA, Orsomando G. Cell Chem Biol. 2017 May 18;24(5):553-564.e4. doi: 10.1016/j.chembiol.2017.03.010. Epub 2017 Apr 13. PubMed |
| A tiling-deletion-based genetic screen for cis-regulatory element identification in mammalian cells. Diao Y, Fang R, Li B, Meng Z, Yu J, Qiu Y, Lin KC, Huang H, Liu T, Marina RJ, Jung I, Shen Y, Guan KL, Ren B. Nat Methods. 2017 Jun;14(6):629-635. doi: 10.1038/nmeth.4264. Epub 2017 Apr 17. PubMed |
| Effects of altered sialic acid biosynthesis on N-linked glycan branching and cell surface interactions. Pham ND, Pang PC, Krishnamurthy S, Wands AM, Grassi P, Dell A, Haslam SM, Kohler JJ. J Biol Chem. 2017 Jun 9;292(23):9637-9651. doi: 10.1074/jbc.M116.764597. Epub 2017 Apr 19. PubMed |
| A 3D in vitro model of the human breast duct: a method to unravel myoepithelial-luminal interactions in the progression of breast cancer. Carter EP, Gopsill JA, Gomm JJ, Jones JL, Grose RP. Breast Cancer Res. 2017 Apr 21;19(1):50. doi: 10.1186/s13058-017-0843-4. PubMed |
Nitric oxide-regulated proteolysis of human CYP2B6 via the ubiquitin-proteasome system.
Lee CM, Tripathi S, Morgan ET.
Free Radic Biol Med. 2017 Jul;108:478-486. doi: 10.1016/j.freeradbiomed.2017.04.015. Epub 2017 Apr 17.
PubMed
Associated Plasmids |
| Bone-in-culture array as a platform to model early-stage bone metastases and discover anti-metastasis therapies. Wang H, Tian L, Goldstein A, Liu J, Lo HC, Sheng K, Welte T, Wong STC, Gugala Z, Stossi F, Zong C, Li Z, Mancini MA, Zhang XH. Nat Commun. 2017 Apr 21;8:15045. doi: 10.1038/ncomms15045. PubMed |
| TIR-domain-containing adapter-inducing interferon-beta (TRIF) forms filamentous structures, whose pro-apoptotic signalling is terminated by autophagy. Gentle IE, McHenry KT, Weber A, Metz A, Kretz O, Porter D, Hacker G. FEBS J. 2017 Jul;284(13):1987-2003. doi: 10.1111/febs.14091. Epub 2017 May 19. PubMed |
| Age-dependent functional crosstalk between cardiac fibroblasts and cardiomyocytes in a 3D engineered cardiac tissue. Li Y, Asfour H, Bursac N. Acta Biomater. 2017 Jun;55:120-130. doi: 10.1016/j.actbio.2017.04.027. Epub 2017 Apr 25. PubMed |
| PARP1 restricts Epstein Barr Virus lytic reactivation by binding the BZLF1 promoter. Lupey-Green LN, Moquin SA, Martin KA, McDevitt SM, Hulse M, Caruso LB, Pomerantz RT, Miranda JL, Tempera I. Virology. 2017 Jul;507:220-230. doi: 10.1016/j.virol.2017.04.006. Epub 2017 Apr 26. PubMed |
| Gli1+ Mesenchymal Stromal Cells Are a Key Driver of Bone Marrow Fibrosis and an Important Cellular Therapeutic Target. Schneider RK, Mullally A, Dugourd A, Peisker F, Hoogenboezem R, Van Strien PMH, Bindels EM, Heckl D, Busche G, Fleck D, Muller-Newen G, Wongboonsin J, Ventura Ferreira M, Puelles VG, Saez-Rodriguez J, Ebert BL, Humphreys BD, Kramann R. Cell Stem Cell. 2017 Jun 1;20(6):785-800.e8. doi: 10.1016/j.stem.2017.03.008. Epub 2017 Apr 27. PubMed |
| JNK-associated scattered growth of YD-10B oral squamous carcinoma cells while maintaining the epithelial phenotype. Lee G, Kim HM. Biochem Biophys Res Commun. 2017 Jun 10;487(4):862-867. doi: 10.1016/j.bbrc.2017.04.142. Epub 2017 Apr 27. PubMed |
| A Novel Agonist of the TRIF Pathway Induces a Cellular State Refractory to Replication of Zika, Chikungunya, and Dengue Viruses. Pryke KM, Abraham J, Sali TM, Gall BJ, Archer I, Liu A, Bambina S, Baird J, Gough M, Chakhtoura M, Haddad EK, Kirby IT, Nilsen A, Streblow DN, Hirsch AJ, Smith JL, DeFilippis VR. MBio. 2017 May 2;8(3). pii: e00452-17. doi: 10.1128/mBio.00452-17. PubMed |
| Aberrant caveolin-1-mediated Smad signaling and proliferation identified by analysis of adenine 474 deletion mutation (c.474delA) in patient fibroblasts: a new perspective on the mechanism of pulmonary hypertension. Marsboom G, Chen Z, Yuan Y, Zhang Y, Tiruppathi C, Loyd JE, Austin ED, Machado RF, Minshall RD, Rehman J, Malik AB. Mol Biol Cell. 2017 May 1;28(9):1177-1185. doi: 10.1091/mbc.E16-11-0790. PubMed |
| Primary cilia control the maturation of tubular lumen in renal collecting duct epithelium. Ernandez T, Komarynets O, Chassot A, Sougoumarin S, Soulie P, Wang Y, Montesano R, Feraille E. Am J Physiol Cell Physiol. 2017 Jul 1;313(1):C94-C107. doi: 10.1152/ajpcell.00290.2016. Epub 2017 May 3. PubMed |
| Releasing Syntaphilin Removes Stressed Mitochondria from Axons Independent of Mitophagy under Pathophysiological Conditions. Lin MY, Cheng XT, Tammineni P, Xie Y, Zhou B, Cai Q, Sheng ZH. Neuron. 2017 May 3;94(3):595-610.e6. doi: 10.1016/j.neuron.2017.04.004. PubMed |
| The role of ORF3 accessory protein in replication of cell-adapted porcine epidemic diarrhea virus (PEDV). Wongthida P, Liwnaree B, Wanasen N, Narkpuk J, Jongkaewwattana A. Arch Virol. 2017 May 4. doi: 10.1007/s00705-017-3390-5. PubMed |
| CHD1 regulates cell fate determination by activation of differentiation-induced genes. Baumgart SJ, Najafova Z, Hossan T, Xie W, Nagarajan S, Kari V, Ditzel N, Kassem M, Johnsen SA. Nucleic Acids Res. 2017 May 5. doi: 10.1093/nar/gkx377. PubMed |
| Linear ubiquitination of cytosolic Salmonella Typhimurium activates NF-kappaB and restricts bacterial proliferation. van Wijk SJL, Fricke F, Herhaus L, Gupta J, Hotte K, Pampaloni F, Grumati P, Kaulich M, Sou YS, Komatsu M, Greten FR, Fulda S, Heilemann M, Dikic I. Nat Microbiol. 2017 May 8;2:17066. doi: 10.1038/nmicrobiol.2017.66. PubMed |
| Electrophysiological Properties and Viability of Neonatal Rat Ventricular Myocyte Cultures with Inducible ChR2 Expression. Li Q, Ni RR, Hong H, Goh KY, Rossi M, Fast VG, Zhou L. Sci Rep. 2017 May 8;7(1):1531. doi: 10.1038/s41598-017-01723-2. PubMed |
| CHD4 Has Oncogenic Functions in Initiating and Maintaining Epigenetic Suppression of Multiple Tumor Suppressor Genes. Xia L, Huang W, Bellani M, Seidman MM, Wu K, Fan D, Nie Y, Cai Y, Zhang YW, Yu LR, Li H, Zahnow CA, Xie W, Chiu Yen RW, Rassool FV, Baylin SB. Cancer Cell. 2017 May 8;31(5):653-668.e7. doi: 10.1016/j.ccell.2017.04.005. PubMed |
| Cap-binding protein 4EHP effects translation silencing by microRNAs. Chapat C, Jafarnejad SM, Matta-Camacho E, Hesketh GG, Gelbart IA, Attig J, Gkogkas CG, Alain T, Stern-Ginossar N, Fabian MR, Gingras AC, Duchaine TF, Sonenberg N. Proc Natl Acad Sci U S A. 2017 May 23;114(21):5425-5430. doi: 10.1073/pnas.1701488114. Epub 2017 May 9. PubMed |
| Protein Phosphatase 2A (PP2A) Regulates EG5 to Control Mitotic Progression. Liu Y, Zhang Z, Liang H, Zhao X, Liang L, Wang G, Yang J, Jin Y, McNutt MA, Yin Y. Sci Rep. 2017 May 9;7(1):1630. doi: 10.1038/s41598-017-01915-w. PubMed |
| Sensing of HIV-1 Entry Triggers a Type I Interferon Response in Human Primary Macrophages. Decalf J, Desdouits M, Rodrigues V, Gobert FX, Gentili M, Marques-Ladeira S, Chamontin C, Mougel M, Cunha de Alencar B, Benaroch P. J Virol. 2017 Jul 12;91(15). pii: e00147-17. doi: 10.1128/JVI.00147-17. Print 2017 Aug 1. PubMed |
| Deletion of the Vaccinia Virus I2 Protein Interrupts Virion Morphogenesis, Leading to Retention of the Scaffold Protein and Mislocalization of Membrane-Associated Entry Proteins. Hyun SI, Weisberg A, Moss B. J Virol. 2017 Jul 12;91(15). pii: e00558-17. doi: 10.1128/JVI.00558-17. Print 2017 Aug 1. PubMed |
| PHD3 is a transcriptional coactivator of HIF-1alpha in nucleus pulposus cells independent of the PKM2-JMJD5 axis. Schoepflin ZR, Silagi ES, Shapiro IM, Risbud MV. FASEB J. 2017 May 11. pii: fj.201601291R. doi: 10.1096/fj.201601291R. PubMed |
| Integrase-Deficient Lentiviral Vector as an All-in-One Platform for Highly Efficient CRISPR/Cas9-Mediated Gene Editing. Ortinski PI, O'Donovan B, Dong X, Kantor B. Mol Ther Methods Clin Dev. 2017 Apr 19;5:153-164. doi: 10.1016/j.omtm.2017.04.002. eCollection 2017 Jun 16. PubMed |
| Structure based discovery of clomifene as a potent inhibitor of cancer-associated mutant IDH1. Zheng M, Sun W, Gao S, Luan S, Li D, Chen R, Zhang Q, Chen L, Huang J, Li H. Oncotarget. 2017 Jul 4;8(27):44255-44265. doi: 10.18632/oncotarget.17464. PubMed |
| Glucose Can Epigenetically Alter the Gene Expression of Neurotrophic Factors in the Murine Brain Cells. Hossain MS, Oomura Y, Katafuchi T. Mol Neurobiol. 2017 May 13. doi: 10.1007/s12035-017-0578-3. PubMed |
| A clinical drug library screen identifies clobetasol propionate as an NRF2 inhibitor with potential therapeutic efficacy in KEAP1 mutant lung cancer. Choi EJ, Jung BJ, Lee SH, Yoo HS, Shin EA, Ko HJ, Chang S, Kim SY, Jeon SM. Oncogene. 2017 Sep 14;36(37):5285-5295. doi: 10.1038/onc.2017.153. Epub 2017 May 15. PubMed |
| Role of NF-E2 related factor 2 (Nrf2) on chemotherapy resistance in acute myeloid leukemia (AML) and the effect of pharmacological inhibition of Nrf2. Karathedath S, Rajamani BM, Musheer Aalam SM, Abraham A, Varatharajan S, Krishnamurthy P, Mathews V, Velayudhan SR, Balasubramanian P. PLoS One. 2017 May 15;12(5):e0177227. doi: 10.1371/journal.pone.0177227. eCollection 2017. PubMed |
Mutant KRAS promotes malignant pleural effusion formation.
Agalioti T, Giannou AD, Krontira AC, Kanellakis NI, Kati D, Vreka M, Pepe M, Spella M, Lilis I, Zazara DE, Nikolouli E, Spiropoulou N, Papadakis A, Papadia K, Voulgaridis A, Harokopos V, Stamou P, Meiners S, Eickelberg O, Snyder LA, Antimisiaris SG, Kardamakis D, Psallidas I, Marazioti A, Stathopoulos GT.
Nat Commun. 2017 May 16;8:15205. doi: 10.1038/ncomms15205.
PubMed
Associated Plasmids |
| A dual phenotype of MDA-MB-468 cancer cells reveals mutual regulation of tensin3 and adhesion plasticity. Vess A, Blache U, Leitner L, Kurz ARM, Ehrenpfordt A, Sixt M, Posern G. J Cell Sci. 2017 Jul 1;130(13):2172-2184. doi: 10.1242/jcs.200899. Epub 2017 May 17. PubMed |
| E2F1 inhibits circulating cholesterol clearance by regulating Pcsk9 expression in the liver. Lai Q, Giralt A, Le May C, Zhang L, Cariou B, Denechaud PD, Fajas L. JCI Insight. 2017 May 18;2(10). pii: 89729. doi: 10.1172/jci.insight.89729. PubMed |
| Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells. Wei HH, Liu Y, Wang Y, Lu Q, Yang X, Li J, Wang Z. J Vis Exp. 2017 Apr 26;(122). doi: 10.3791/54967. PubMed |
Homology-mediated end joining-based targeted integration using CRISPR/Cas9.
Yao X, Wang X, Hu X, Liu Z, Liu J, Zhou H, Shen X, Wei Y, Huang Z, Ying W, Wang Y, Nie YH, Zhang CC, Li S, Cheng L, Wang Q, Wu Y, Huang P, Sun Q, Shi L, Yang H.
Cell Res. 2017 May 19. doi: 10.1038/cr.2017.76.
PubMed
Associated Plasmids |
| Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function. Sakamaki JI, Wilkinson S, Hahn M, Tasdemir N, O'Prey J, Clark W, Hedley A, Nixon C, Long JS, New M, Van Acker T, Tooze SA, Lowe SW, Dikic I, Ryan KM. Mol Cell. 2017 May 18;66(4):517-532.e9. doi: 10.1016/j.molcel.2017.04.027. PubMed |
| Shedding of host autophagic proteins from the parasitophorous vacuolar membrane of Plasmodium berghei. Agop-Nersesian C, De Niz M, Niklaus L, Prado M, Eickel N, Heussler VT. Sci Rep. 2017 May 19;7(1):2191. doi: 10.1038/s41598-017-02156-7. PubMed |
| The N-terminus of the prion protein is a toxic effector regulated by the C-terminus. Wu B, McDonald AJ, Markham K, Rich CB, McHugh KP, Tatzelt J, Colby DW, Millhauser GL, Harris DA. Elife. 2017 May 20;6. pii: e23473. doi: 10.7554/eLife.23473. PubMed |
| CRISPR/Cas9 - Mediated Precise Targeted Integration In Vivo Using a Double Cut Donor with Short Homology Arms. Yao X, Wang X, Liu J, Hu X, Shi L, Shen X, Ying W, Sun X, Wang X, Huang P, Yang H. EBioMedicine. 2017 Jun;20:19-26. doi: 10.1016/j.ebiom.2017.05.015. Epub 2017 May 11. PubMed |
| A novel isoform of TET1 that lacks a CXXC domain is overexpressed in cancer. Good CR, Madzo J, Patel B, Maegawa S, Engel N, Jelinek J, Issa JJ. Nucleic Acids Res. 2017 May 22. doi: 10.1093/nar/gkx435. PubMed |
| Polylactide- and polycaprolactone-based substrates enhance angiogenic potential of human umbilical cord-derived mesenchymal stem cells in vitro - implications for cardiovascular repair. Sekula M, Domalik-Pyzik P, Morawska-Chochol A, Bobis-Wozowicz S, Karnas E, Noga S, Boruczkowski D, Adamiak M, Madeja Z, Chlopek J, Zuba-Surma EK. Mater Sci Eng C Mater Biol Appl. 2017 Aug 1;77:521-533. doi: 10.1016/j.msec.2017.03.281. Epub 2017 Mar 30. PubMed |
| cGAS is essential for cellular senescence. Yang H, Wang H, Ren J, Chen Q, Chen ZJ. Proc Natl Acad Sci U S A. 2017 Jun 6;114(23):E4612-E4620. doi: 10.1073/pnas.1705499114. Epub 2017 May 22. PubMed |
| Discovery of Stromal Regulatory Networks that Suppress Ras-Sensitized Epithelial Cell Proliferation. Liu H, Dowdle JA, Khurshid S, Sullivan NJ, Bertos N, Rambani K, Mair M, Daniel P, Wheeler E, Tang X, Toth K, Lause M, Harrigan ME, Eiring K, Sullivan C, Sullivan MJ, Chang SW, Srivastava S, Conway JS, Kladney R, McElroy J, Bae S, Lu Y, Tofigh A, Saleh SMI, Fernandez SA, Parvin JD, Coppola V, Macrae ER, Majumder S, Shapiro CL, Yee LD, Ramaswamy B, Hallett M, Ostrowski MC, Park M, Chamberlin HM, Leone G. Dev Cell. 2017 May 22;41(4):392-407.e6. doi: 10.1016/j.devcel.2017.04.024. PubMed |
| The ubiquitin ligase STUB1 regulates stability and activity of RUNX1 and RUNX1-RUNX1T1. Yonezawa T, Takahashi H, Shikata S, Liu X, Tamura M, Asada S, Fukushima T, Fukuyama T, Tanaka Y, Sawasaki T, Kitamura T, Goyama S. J Biol Chem. 2017 Jul 28;292(30):12528-12541. doi: 10.1074/jbc.M117.785675. Epub 2017 May 23. PubMed |
| Extracellular Interactions between Hepatitis C Virus and Secreted Apolipoprotein E. Li Z, Li Y, Bi Y, Zhang H, Yao Y, Li Q, Cun W, Dong S. J Virol. 2017 Jul 12;91(15). pii: e02227-16. doi: 10.1128/JVI.02227-16. Print 2017 Aug 1. PubMed |
| CD146 (MCAM) in human cs-DLK1-/cs-CD34+ adipose stromal/progenitor cells. Horl S, Ejaz A, Ernst S, Mattesich M, Kaiser A, Jenewein B, Zwierzina ME, Hammerle S, Miggitsch C, Mitterberger-Vogt MC, Krautgasser C, Pierer G, Zwerschke W. Stem Cell Res. 2017 Jul;22:1-12. doi: 10.1016/j.scr.2017.05.004. Epub 2017 May 17. PubMed |
| Role of peptidylarginine deiminase 2 (PAD2) in mammary carcinoma cell migration. Horibata S, Rogers KE, Sadegh D, Anguish LJ, McElwee JL, Shah P, Thompson PR, Coonrod SA. BMC Cancer. 2017 May 26;17(1):378. doi: 10.1186/s12885-017-3354-x. PubMed |
| Knockdown of sodium-calcium exchanger 1 induces epithelial-to-mesenchymal transition in kidney epithelial cells. Balasubramaniam SL, Gopalakrishnapillai A, Petrelli NJ, Barwe SP. J Biol Chem. 2017 Jul 7;292(27):11388-11399. doi: 10.1074/jbc.M116.752352. Epub 2017 May 26. PubMed |
| Single-Virus Droplet Microfluidics for High-Throughput Screening of Neutralizing Epitopes on HIV Particles. Chaipan C, Pryszlak A, Dean H, Poignard P, Benes V, Griffiths AD, Merten CA. Cell Chem Biol. 2017 Jun 22;24(6):751-757.e3. doi: 10.1016/j.chembiol.2017.05.009. Epub 2017 May 25. PubMed |
| PI3K class II alpha regulates delta-opioid receptor export from the trans-Golgi network. Shiwarski DJ, Darr M, Telmer CA, Bruchez MP, Puthenveedu MA. Mol Biol Cell. 2017 Aug 1;28(16):2202-2219. doi: 10.1091/mbc.E17-01-0030. Epub 2017 May 31. PubMed |
CRISPR-Cas9-induced t(11;19)/MLL-ENL translocations initiate leukemia in human hematopoietic progenitor cells in vivo.
Reimer J, Knoess S, Labuhn M, Charpentier EM, Gohring G, Schlegelberger B, Klusmann JH, Heckl D.
Haematologica. 2017 Jun 1. pii: haematol.2017.164046. doi: 10.3324/haematol.2017.164046.
PubMed
Associated Plasmids |
| Synchronized HIV assembly by tunable PIP2 changes reveals PIP2 requirement for stable Gag anchoring. Mucksch F, Laketa V, Muller B, Schultz C, Krausslich HG. Elife. 2017 Jun 2;6. pii: e25287. doi: 10.7554/eLife.25287. PubMed |
| The PYRIN domain-only protein POP2 inhibits inflammasome priming and activation. Ratsimandresy RA, Chu LH, Khare S, de Almeida L, Gangopadhyay A, Indramohan M, Misharin AV, Greaves DR, Perlman H, Dorfleutner A, Stehlik C. Nat Commun. 2017 Jun 5;8:15556. doi: 10.1038/ncomms15556. PubMed |
| Effect of tryptase inhibition on joint inflammation: a pharmacological and lentivirus-mediated gene transfer study. Denadai-Souza A, Ribeiro CM, Rolland C, Thouard A, Deraison C, Scavone C, Gonzalez-Dunia D, Vergnolle N, Avellar MCW. Arthritis Res Ther. 2017 Jun 6;19(1):124. doi: 10.1186/s13075-017-1326-9. PubMed |
| Tightly controlled MRTF-A activity regulates epithelial differentiation during formation of mammary acini. Seifert A, Posern G. Breast Cancer Res. 2017 Jun 7;19(1):68. doi: 10.1186/s13058-017-0860-3. PubMed |
| Linaclotide activates guanylate cyclase-C/cGMP/protein kinase-II-dependent trafficking of CFTR in the intestine. Ahsan MK, Tchernychev B, Kessler MM, Solinga RM, Arthur D, Linde CI, Silos-Santiago I, Hannig G, Ameen NA. Physiol Rep. 2017 Jun;5(11). pii: 5/11/e13299. doi: 10.14814/phy2.13299. PubMed |
| The metalloproteinase ADAM8 promotes leukocyte recruitment in vitro and in acute lung inflammation. Dreymueller D, Pruessmeyer J, Schumacher J, Fellendorf S, Hess FM, Seifert A, Babendreyer A, Bartsch JW, Ludwig A. Am J Physiol Lung Cell Mol Physiol. 2017 Jun 8:ajplung.00444.2016. doi: 10.1152/ajplung.00444.2016. PubMed |
| Integrin alpha7 Is a Functional Marker and Potential Therapeutic Target in Glioblastoma. Haas TL, Sciuto MR, Brunetto L, Valvo C, Signore M, Fiori ME, di Martino S, Giannetti S, Morgante L, Boe A, Patrizii M, Warnken U, Schnolzer M, Ciolfi A, Di Stefano C, Biffoni M, Ricci-Vitiani L, Pallini R, De Maria R. Cell Stem Cell. 2017 Jul 6;21(1):35-50.e9. doi: 10.1016/j.stem.2017.04.009. Epub 2017 Jun 9. PubMed |
Construction and Screening of a Lentiviral Secretome Library.
Liu T, Jia P, Ma H, Reed SA, Luo X, Larman HB, Schultz PG.
Cell Chem Biol. 2017 Jun 22;24(6):767-771.e3. doi: 10.1016/j.chembiol.2017.05.017. Epub 2017 Jun 9.
PubMed
Associated Plasmids |
| Antigen Presentation by Individually Transferred HLA Class I Genes in HLA-A, HLA-B, HLA-C Null Human Cell Line Generated Using the Multiplex CRISPR-Cas9 System. Hong CH, Sohn HJ, Lee HJ, Cho HI, Kim TG. J Immunother. 2017 Jul/Aug;40(6):201-210. doi: 10.1097/CJI.0000000000000176. PubMed |
| Ohmyungsamycins promote antimicrobial responses through autophagy activation via AMP-activated protein kinase pathway. Kim TS, Shin YH, Lee HM, Kim JK, Choe JH, Jang JC, Um S, Jin HS, Komatsu M, Cha GH, Chae HJ, Oh DC, Jo EK. Sci Rep. 2017 Jun 13;7(1):3431. doi: 10.1038/s41598-017-03477-3. PubMed |
| Reduction of infection by inhibiting mTOR pathway is associated with reversed repression of type I interferon by porcine reproductive and respiratory syndrome virus. Liu Q, Miller LC, Blecha F, Sang Y. J Gen Virol. 2017 Jun;98(6):1316-1328. doi: 10.1099/jgv.0.000802. Epub 2017 Jun 14. PubMed |
| Defects in autophagosome-lysosome fusion underlie Vici syndrome, a neurodevelopmental disorder with multisystem involvement. Hori I, Otomo T, Nakashima M, Miya F, Negishi Y, Shiraishi H, Nonoda Y, Magara S, Tohyama J, Okamoto N, Kumagai T, Shimoda K, Yukitake Y, Kajikawa D, Morio T, Hattori A, Nakagawa M, Ando N, Nishino I, Kato M, Tsunoda T, Saitsu H, Kanemura Y, Yamasaki M, Kosaki K, Matsumoto N, Yoshimori T, Saitoh S. Sci Rep. 2017 Jun 14;7(1):3552. doi: 10.1038/s41598-017-02840-8. PubMed |
| BAIAP3, a C2 domain-containing Munc13 protein, controls the fate of dense-core vesicles in neuroendocrine cells. Zhang X, Jiang S, Mitok KA, Li L, Attie AD, Martin TFJ. J Cell Biol. 2017 Jul 3;216(7):2151-2166. doi: 10.1083/jcb.201702099. Epub 2017 Jun 16. PubMed |
| Autophagy impairment mediated by S-nitrosation of ATG4B leads to neurotoxicity in response to hyperglycemia. Li Y, Zhang Y, Wang L, Wang P, Xue Y, Li X, Qiao X, Zhang X, Xu T, Liu G, Li P, Chen C. Autophagy. 2017 Jul 3;13(7):1145-1160. doi: 10.1080/15548627.2017.1320467. PubMed |
| Generation of Induced Pluripotent Stem Cells in Defined Three-Dimensional Hydrogels. Caiazzo M, Tabata Y, Lutolf M. Methods Mol Biol. 2017;1612:65-78. doi: 10.1007/978-1-4939-7021-6_5. PubMed |
| Sam68 Allows Selective Targeting of Human Cancer Stem Cells. Benoit YD, Mitchell RR, Risueno RM, Orlando L, Tanasijevic B, Boyd AL, Aslostovar L, Salci KR, Shapovalova Z, Russell J, Eguchi M, Golubeva D, Graham M, Xenocostas A, Trus MR, Foley R, Leber B, Collins TJ, Bhatia M. Cell Chem Biol. 2017 Jul 20;24(7):833-844.e9. doi: 10.1016/j.chembiol.2017.05.026. Epub 2017 Jun 22. PubMed |
| Targeting MCL-1 sensitizes human esophageal squamous cell carcinoma cells to cisplatin-induced apoptosis. Yu X, Li W, Xia Z, Xie L, Ma X, Liang Q, Liu L, Wang J, Zhou X, Yang Y, Liu H. BMC Cancer. 2017 Jun 28;17(1):449. doi: 10.1186/s12885-017-3442-y. PubMed |
| TTC19 Plays a Husbandry Role on UQCRFS1 Turnover in the Biogenesis of Mitochondrial Respiratory Complex III. Bottani E, Cerutti R, Harbour ME, Ravaglia S, Dogan SA, Giordano C, Fearnley IM, D'Amati G, Viscomi C, Fernandez-Vizarra E, Zeviani M. Mol Cell. 2017 Jul 6;67(1):96-105.e4. doi: 10.1016/j.molcel.2017.06.001. Epub 2017 Jun 29. PubMed |
| Lack of evidence for involvement of TonEBP and hyperosmotic stimulus in induction of autophagy in the nucleus pulposus. Liu C, Choi H, Johnson ZI, Tian J, Shapiro IM, Risbud MV. Sci Rep. 2017 Jul 3;7(1):4543. doi: 10.1038/s41598-017-04876-2. PubMed |
| In-Cell Western Assays to Evaluate Hantaan Virus Replication as a Novel Approach to Screen Antiviral Molecules and Detect Neutralizing Antibody Titers. Ma HW, Ye W, Chen HS, Nie TJ, Cheng LF, Zhang L, Han PJ, Wu XA, Xu ZK, Lei YF, Zhang FL. Front Cell Infect Microbiol. 2017 Jun 20;7:269. doi: 10.3389/fcimb.2017.00269. eCollection 2017. PubMed |
| Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway. Viswanathan VS, Ryan MJ, Dhruv HD, Gill S, Eichhoff OM, Seashore-Ludlow B, Kaffenberger SD, Eaton JK, Shimada K, Aguirre AJ, Viswanathan SR, Chattopadhyay S, Tamayo P, Yang WS, Rees MG, Chen S, Boskovic ZV, Javaid S, Huang C, Wu X, Tseng YY, Roider EM, Gao D, Cleary JM, Wolpin BM, Mesirov JP, Haber DA, Engelman JA, Boehm JS, Kotz JD, Hon CS, Chen Y, Hahn WC, Levesque MP, Doench JG, Berens ME, Shamji AF, Clemons PA, Stockwell BR, Schreiber SL. Nature. 2017 Jul 27;547(7664):453-457. doi: 10.1038/nature23007. Epub 2017 Jul 5. PubMed |
| Recombinant elastin based nanoparticles for targeted gene therapy. Monfort DA, Koria P. Gene Ther. 2017 Jul 5. doi: 10.1038/gt.2017.54. PubMed |
| Coculture of mesenchymal stem cells and endothelial cells enhances host tissue integration and epidermis maturation through AKT activation in gelatin methacryloyl hydrogel-based skin model. Zhang X, Li J, Ye P, Gao G, Hubbell K, Cui X. Acta Biomater. 2017 Jul 3. pii: S1742-7061(17)30429-4. doi: 10.1016/j.actbio.2017.07.001. PubMed |
| The E3 ubiquitin ligase and RNA-binding protein ZNF598 orchestrates ribosome quality control of premature polyadenylated mRNAs. Garzia A, Jafarnejad SM, Meyer C, Chapat C, Gogakos T, Morozov P, Amiri M, Shapiro M, Molina H, Tuschl T, Sonenberg N. Nat Commun. 2017 Jul 7;8:16056. doi: 10.1038/ncomms16056. PubMed |
| Increased levels of Gab1 and Gab2 adaptor proteins skew IL-4 signaling toward M2 macrophage-driven pulmonary fibrosis in mice. Guo X, Li T, Xu Y, Xu X, Zhu Z, Zhang Y, Xu J, Xu K, Cheng H, Zhang X, Ke Y. J Biol Chem. 2017 Jul 7. pii: jbc.M117.802066. doi: 10.1074/jbc.M117.802066. PubMed |
| Role of integrin-linked kinase in regulating the protein stability of the MUC1-C oncoprotein in pancreatic cancer cells. Huang HL, Wu HY, Chu PC, Lai IL, Huang PH, Kulp SK, Pan SL, Teng CM, Chen CS. Oncogenesis. 2017 Jul 10;6(7):e359. doi: 10.1038/oncsis.2017.61. PubMed |
| Manipulation of nuclear architecture through CRISPR-mediated chromosomal looping. Morgan SL, Mariano NC, Bermudez A, Arruda NL, Wu F, Luo Y, Shankar G, Jia L, Chen H, Hu JF, Hoffman AR, Huang CC, Pitteri SJ, Wang KC. Nat Commun. 2017 Jul 13;8:15993. doi: 10.1038/ncomms15993. PubMed |
| Nrf2 deficiency exacerbates ochratoxin A-induced toxicity in vitro and in vivo. Loboda A, Stachurska A, Sobczak M, Podkalicka P, Mucha O, Jozkowicz A, Dulak J. Toxicology. 2017 Aug 15;389:42-52. doi: 10.1016/j.tox.2017.07.004. Epub 2017 Jul 12. PubMed |
| CRISPR/Cas9-Mediated Scanning for Regulatory Elements Required for HPRT1 Expression via Thousands of Large, Programmed Genomic Deletions. Gasperini M, Findlay GM, McKenna A, Milbank JH, Lee C, Zhang MD, Cusanovich DA, Shendure J. Am J Hum Genet. 2017 Aug 3;101(2):192-205. doi: 10.1016/j.ajhg.2017.06.010. Epub 2017 Jul 14. PubMed |
| Intratumoral Lentivector-Mediated TGF-beta1 Gene Downregulation As a Potent Strategy for Enhancing the Antitumor Effect of Therapy Composed of Cyclophosphamide and Dendritic Cells. Rossowska J, Anger N, Szczygiel A, Mierzejewska J, Pajtasz-Piasecka E. Front Immunol. 2017 Jun 30;8:713. doi: 10.3389/fimmu.2017.00713. eCollection 2017. PubMed |
| Optogenetic Control of Ras/Erk Signaling Using the Phy-PIF System. Goglia AG, Wilson MZ, DiGiorno DB, Toettcher JE. Methods Mol Biol. 2017;1636:3-20. doi: 10.1007/978-1-4939-7154-1_1. PubMed |
| Single-Cell Imaging of ERK Signaling Using Fluorescent Biosensors. Pargett M, Gillies TE, Teragawa CK, Sparta B, Albeck JG. Methods Mol Biol. 2017;1636:35-59. doi: 10.1007/978-1-4939-7154-1_3. PubMed |
| EINCR1 is an EGF inducible lincRNA overexpressed in lung adenocarcinomas. Nowicki-Osuch K, Li Y, Challinor M, Gerrard DT, Hanley NA, Sharrocks AD. PLoS One. 2017 Jul 21;12(7):e0181902. doi: 10.1371/journal.pone.0181902. eCollection 2017. PubMed |
| P2X receptors up-regulate the cell-surface expression of the neuronal glycine transporter GlyT2. Villarejo-Lopez L, Jimenez E, Bartolome-Martin D, Zafra F, Lapunzina P, Aragon C, Lopez-Corcuera B. Neuropharmacology. 2017 Oct;125:99-116. doi: 10.1016/j.neuropharm.2017.07.018. Epub 2017 Jul 19. PubMed |
| Stimulus-evoked ERK-dependent phosphorylation of activity-regulated cytoskeleton-associated protein (Arc) regulates its neuronal subcellular localization. Nikolaienko O, Eriksen MS, Patil S, Bito H, Bramham CR. Neuroscience. 2017 Sep 30;360:68-80. doi: 10.1016/j.neuroscience.2017.07.026. Epub 2017 Jul 21. PubMed |
| Actomyosin drives cancer cell nuclear dysmorphia and threatens genome stability. Takaki T, Montagner M, Serres MP, Le Berre M, Russell M, Collinson L, Szuhai K, Howell M, Boulton SJ, Sahai E, Petronczki M. Nat Commun. 2017 Jul 24;8:16013. doi: 10.1038/ncomms16013. PubMed |
| NFATc2 enhances tumor-initiating phenotypes through the NFATc2/SOX2/ALDH axis in lung adenocarcinoma. Xiao ZJ, Liu J, Wang SQ, Zhu Y, Gao XY, Tin VP, Qin J, Wang JW, Wong MP. Elife. 2017 Jul 24;6. doi: 10.7554/eLife.26733. PubMed |
| Circadian repressors CRY1 and CRY2 broadly interact with nuclear receptors and modulate transcriptional activity. Kriebs A, Jordan SD, Soto E, Henriksson E, Sandate CR, Vaughan ME, Chan AB, Duglan D, Papp SJ, Huber AL, Afetian ME, Yu RT, Zhao X, Downes M, Evans RM, Lamia KA. Proc Natl Acad Sci U S A. 2017 Aug 15;114(33):8776-8781. doi: 10.1073/pnas.1704955114. Epub 2017 Jul 27. PubMed |
| miR-151a induces partial EMT by regulating E-cadherin in NSCLC cells. Daugaard I, Sanders KJ, Idica A, Vittayarukskul K, Hamdorf M, Krog JD, Chow R, Jury D, Hansen LL, Hager H, Lamy P, Choi CL, Agalliu D, Zisoulis DG, Pedersen IM. Oncogenesis. 2017 Jul 31;6(7):e366. doi: 10.1038/oncsis.2017.66. PubMed |
| FiloQuant reveals increased filopodia density during breast cancer progression. Jacquemet G, Paatero I, Carisey AF, Padzik A, Orange JS, Hamidi H, Ivaska J. J Cell Biol. 2017 Oct 2;216(10):3387-3403. doi: 10.1083/jcb.201704045. Epub 2017 Aug 1. PubMed |
| Connexin 43 is required for the maintenance of mitochondrial integrity in brown adipose tissue. Kim SN, Kwon HJ, Im SW, Son YH, Akindehin S, Jung YS, Lee SJ, Rhyu IJ, Kim IY, Seong JK, Lee J, Yoo HC, Granneman JG, Lee YH. Sci Rep. 2017 Aug 2;7(1):7159. doi: 10.1038/s41598-017-07658-y. PubMed |
| Aneuploid Cell Survival Relies upon Sphingolipid Homeostasis. Tang YC, Yuwen H, Wang K, Bruno PM, Bullock K, Deik A, Santaguida S, Trakala M, Pfau SJ, Zhong N, Huang T, Wang L, Clish CB, Hemann MT, Amon A. Cancer Res. 2017 Oct 1;77(19):5272-5286. doi: 10.1158/0008-5472.CAN-17-0049. Epub 2017 Aug 3. PubMed |
| Genome-scale activation screen identifies a lncRNA locus regulating a gene neighbourhood. Joung J, Engreitz JM, Konermann S, Abudayyeh OO, Verdine VK, Aguet F, Gootenberg JS, Sanjana NE, Wright JB, Fulco CP, Tseng YY, Yoon CH, Boehm JS, Lander ES, Zhang F. Nature. 2017 Aug 11. doi: 10.1038/nature23451. PubMed |
| PDI is an essential redox-sensitive activator of PERK during the unfolded protein response (UPR). Kranz P, Neumann F, Wolf A, Classen F, Pompsch M, Ocklenburg T, Baumann J, Janke K, Baumann M, Goepelt K, Riffkin H, Metzen E, Brockmeier U. Cell Death Dis. 2017 Aug 10;8(8):e2986. doi: 10.1038/cddis.2017.369. PubMed |
| Flow induced adherens junction remodeling driven by cytoskeletal forces. Verma D, Bajpai VK, Ye N, Maneshi MM, Jetta D, Andreadis ST, Sachs F, Hua SZ. Exp Cell Res. 2017 Oct 15;359(2):327-336. doi: 10.1016/j.yexcr.2017.08.009. Epub 2017 Aug 10. PubMed |
A genetically encoded tool for manipulation of NADP+/NADPH in living cells.
Cracan V, Titov DV, Shen H, Grabarek Z, Mootha VK.
Nat Chem Biol. 2017 Aug 7. doi: 10.1038/nchembio.2454.
PubMed
Associated Plasmids |
| Development of Hepatocyte-like Cell Derived from Human Induced Pluripotent Stem cell as a Host for Clinically Isolated Hepatitis C Virus. Sa-Ngiamsuntorn K, Hongeng S, Wongkajornsilp A. Curr Protoc Stem Cell Biol. 2017 Aug 14;42:4A.13.1-4A.13.34. doi: 10.1002/cpsc.35. PubMed |
| Transcription factor ZNF148 is a negative regulator of human muscle differentiation. Bakke J, Wright WC, Zamora AE, Ong SS, Wang YM, Hoyer JD, Brewer CT, Thomas PG, Chen T. Sci Rep. 2017 Aug 15;7(1):8138. doi: 10.1038/s41598-017-08267-5. PubMed |
| Stromal R-spondin orchestrates gastric epithelial stem cells and gland homeostasis. Sigal M, Logan CY, Kapalczynska M, Mollenkopf HJ, Berger H, Wiedenmann B, Nusse R, Amieva MR, Meyer TF. Nature. 2017 Aug 24;548(7668):451-455. doi: 10.1038/nature23642. Epub 2017 Aug 16. PubMed |
| CRISPR/Cas9 editing reveals novel mechanisms of clustered microRNA regulation and function. Lataniotis L, Albrecht A, Kok FO, Monfries CAL, Benedetti L, Lawson ND, Hughes SM, Steinhofel K, Mayr M, Zampetaki A. Sci Rep. 2017 Aug 17;7(1):8585. doi: 10.1038/s41598-017-09268-0. PubMed |
| A reversible phospho-switch mediated by ULK1 regulates the activity of autophagy protease ATG4B. Pengo N, Agrotis A, Prak K, Jones J, Ketteler R. Nat Commun. 2017 Aug 18;8(1):294. doi: 10.1038/s41467-017-00303-2. PubMed |
Tracing Information Flow from Erk to Target Gene Induction Reveals Mechanisms of Dynamic and Combinatorial Control.
Wilson MZ, Ravindran PT, Lim WA, Toettcher JE.
Mol Cell. 2017 Sep 7;67(5):757-769.e5. doi: 10.1016/j.molcel.2017.07.016. Epub 2017 Aug 17.
PubMed
Associated Plasmids |
| Absolute measurement of gene transcripts with Selfie-digital PCR. Podlesniy P, Trullas R. Sci Rep. 2017 Aug 21;7(1):8328. doi: 10.1038/s41598-017-08270-w. PubMed |
| Nitric oxide stimulates cellular degradation of human CYP51A1, the highly conserved lanosterol 14alpha-demethylase. Park JW, Byrd A, Lee CM, Morgan ET. Biochem J. 2017 Sep 14;474(19):3241-3252. doi: 10.1042/BCJ20170459. PubMed |
| ZIC2 Is Essential for Maintenance of Latency and Is a Target of an Immediate Early Protein during Kaposi's Sarcoma-Associated Herpesvirus Lytic Reactivation. Lyu Y, Nakano K, Davis RR, Tepper CG, Campbell M, Izumiya Y. J Virol. 2017 Oct 13;91(21). pii: JVI.00980-17. doi: 10.1128/JVI.00980-17. Print 2017 Nov 1. PubMed |
| Smac mimetics and oncolytic viruses synergize in driving anticancer T-cell responses through complementary mechanisms. Kim DS, Dastidar H, Zhang C, Zemp FJ, Lau K, Ernst M, Rakic A, Sikdar S, Rajwani J, Naumenko V, Balce DR, Ewanchuk BW, Tailor P, Yates RM, Jenne C, Gafuik C, Mahoney DJ. Nat Commun. 2017 Aug 24;8(1):344. doi: 10.1038/s41467-017-00324-x. PubMed |
| ESRRA (estrogen-related receptor alpha) is a key coordinator of transcriptional and post-translational activation of autophagy to promote innate host defense. Kim SY, Yang CS, Lee HM, Kim JK, Kim YS, Kim YR, Kim JS, Kim TS, Yuk JM, Dufour CR, Lee SH, Kim JM, Choi HS, Giguere V, Jo EK. Autophagy. 2018;14(1):152-168. doi: 10.1080/15548627.2017.1339001. Epub 2017 Sep 1. PubMed |
DNA Cross-Bridging Shapes a Single Nucleus from a Set of Mitotic Chromosomes.
Samwer M, Schneider MWG, Hoefler R, Schmalhorst PS, Jude JG, Zuber J, Gerlich DW.
Cell. 2017 Aug 24;170(5):956-972.e23. doi: 10.1016/j.cell.2017.07.038.
PubMed
Associated Plasmids |
| TNF-alpha promotes nuclear enrichment of the transcription factor TonEBP/NFAT5 to selectively control inflammatory but not osmoregulatory responses in nucleus pulposus cells. Johnson ZI, Doolittle AC, Snuggs JW, Shapiro IM, Le Maitre CL, Risbud MV. J Biol Chem. 2017 Oct 20;292(42):17561-17575. doi: 10.1074/jbc.M117.790378. Epub 2017 Aug 25. PubMed |
| Palmitoylation of the ciliary GTPase ARL13b is necessary for its stability and its role in cilia formation. Roy K, Jerman S, Jozsef L, McNamara T, Onyekaba G, Sun Z, Marin EP. J Biol Chem. 2017 Oct 27;292(43):17703-17717. doi: 10.1074/jbc.M117.792937. Epub 2017 Aug 28. PubMed |
| Prolonged exposure of mouse and human podocytes to insulin induces insulin resistance through lysosomal and proteasomal degradation of the insulin receptor. Lay AC, Hurcombe JA, Betin VMS, Barrington F, Rollason R, Ni L, Gillam L, Pearson GME, Ostergaard MV, Hamidi H, Lennon R, Welsh GI, Coward RJM. Diabetologia. 2017 Nov;60(11):2299-2311. doi: 10.1007/s00125-017-4394-0. Epub 2017 Aug 29. PubMed |
| Generation and characterization of transgenic mouse mesenchymal stem cell lines expressing hIGF-1 or hG-CSF. Goncalves GVM, Silva DN, Carvalho RH, Souza BSF, da Silva KN, Vasconcelos JF, Paredes BD, Nonaka CKV, Ribeiro-Dos-Santos R, Soares MBP. Cytotechnology. 2018 Apr;70(2):577-591. doi: 10.1007/s10616-017-0131-2. Epub 2017 Sep 2. PubMed |
| Global Inhibition with Specific Activation: How p53 and MYC Redistribute the Transcriptome in the DNA Double-Strand Break Response. Porter JR, Fisher BE, Baranello L, Liu JC, Kambach DM, Nie Z, Koh WS, Luo J, Stommel JM, Levens D, Batchelor E. Mol Cell. 2017 Sep 21;67(6):1013-1025.e9. doi: 10.1016/j.molcel.2017.07.028. Epub 2017 Aug 31. PubMed |
| Palmitoylation-dependent activation of MC1R prevents melanomagenesis. Chen S, Zhu B, Yin C, Liu W, Han C, Chen B, Liu T, Li X, Chen X, Li C, Hu L, Zhou J, Xu ZX, Gao X, Wu X, Goding CR, Cui R. Nature. 2017 Sep 21;549(7672):399-403. doi: 10.1038/nature23887. Epub 2017 Sep 6. PubMed |
| WNT/beta-Catenin Pathway and Epigenetic Mechanisms Regulate the Pitt-Hopkins Syndrome and Schizophrenia Risk Gene TCF4. Hennig KM, Fass DM, Zhao WN, Sheridan SD, Fu T, Erdin S, Stortchevoi A, Lucente D, Cody JD, Sweetser D, Gusella JF, Talkowski ME, Haggarty SJ. Mol Neuropsychiatry. 2017 Jul;3(1):53-71. doi: 10.1159/000475666. Epub 2017 Jul 14. PubMed |
| New in vivo avatars of diffuse intrinsic pontine gliomas (DIPG) from stereotactic biopsies performed at diagnosis. Plessier A, Le Dret L, Varlet P, Beccaria K, Lacombe J, Meriaux S, Geffroy F, Fiette L, Flamant P, Chretien F, Blauwblomme T, Puget S, Grill J, Debily MA, Castel D. Oncotarget. 2017 Feb 2;8(32):52543-52559. doi: 10.18632/oncotarget.15002. eCollection 2017 Aug 8. PubMed |
| Modulation of hippocampal synapse maturation by activity-regulated E3 ligase via non-canonical pathway. Kumari P, Srinivasan B, Banerjee S. Neuroscience. 2017 Nov 19;364:226-241. doi: 10.1016/j.neuroscience.2017.08.057. Epub 2017 Sep 8. PubMed |
| Replacing reprogramming factors with antibodies selected from combinatorial antibody libraries. Blanchard JW, Xie J, El-Mecharrafie N, Gross S, Lee S, Lerner RA, Baldwin KK. Nat Biotechnol. 2017 Oct;35(10):960-968. doi: 10.1038/nbt.3963. Epub 2017 Sep 11. PubMed |
| Enhancing CD8(+) T Cell Fatty Acid Catabolism within a Metabolically Challenging Tumor Microenvironment Increases the Efficacy of Melanoma Immunotherapy. Zhang Y, Kurupati R, Liu L, Zhou XY, Zhang G, Hudaihed A, Filisio F, Giles-Davis W, Xu X, Karakousis GC, Schuchter LM, Xu W, Amaravadi R, Xiao M, Sadek N, Krepler C, Herlyn M, Freeman GJ, Rabinowitz JD, Ertl HCJ. Cancer Cell. 2017 Sep 11;32(3):377-391.e9. doi: 10.1016/j.ccell.2017.08.004. PubMed |
| KIF7 attenuates prostate tumor growth through LKB1-mediated AKT inhibition. Wong KY, Liu J, Chan KW. Oncotarget. 2017 Apr 26;8(33):54558-54571. doi: 10.18632/oncotarget.17421. eCollection 2017 Aug 15. PubMed |
| Exosome-mediated miR-146a transfer suppresses type I interferon response and facilitates EV71 infection. Fu Y, Zhang L, Zhang F, Tang T, Zhou Q, Feng C, Jin Y, Wu Z. PLoS Pathog. 2017 Sep 14;13(9):e1006611. doi: 10.1371/journal.ppat.1006611. eCollection 2017 Sep. PubMed |
| Optimized PEI-based Transfection Method for Transient Transfection and Lentiviral Production. Yang S, Zhou X, Li R, Fu X, Sun P. Curr Protoc Chem Biol. 2017 Sep 14;9(3):147-157. doi: 10.1002/cpch.25. PubMed |
| Loss of native alpha-synuclein multimerization by strategically mutating its amphipathic helix causes abnormal vesicle interactions in neuronal cells. Dettmer U, Ramalingam N, von Saucken VE, Kim TE, Newman AJ, Terry-Kantor E, Nuber S, Ericsson M, Fanning S, Bartels T, Lindquist S, Levy OA, Selkoe D. Hum Mol Genet. 2017 Sep 15;26(18):3466-3481. doi: 10.1093/hmg/ddx227. PubMed |
| Integrin alpha4 Overexpression on Rat Mesenchymal Stem Cells Enhances Transmigration and Reduces Cerebral Embolism After Intracarotid Injection. Cui LL, Nitzsche F, Pryazhnikov E, Tibeykina M, Tolppanen L, Rytkonen J, Huhtala T, Mu JW, Khiroug L, Boltze J, Jolkkonen J. Stroke. 2017 Oct;48(10):2895-2900. doi: 10.1161/STROKEAHA.117.017809. Epub 2017 Sep 15. PubMed |
| SmartFlares fail to reflect their target transcripts levels. Czarnek M, Bereta J. Sci Rep. 2017 Sep 15;7(1):11682. doi: 10.1038/s41598-017-11067-6. PubMed |
| Targeted Disruption of V600E-Mutant BRAF Gene by CRISPR-Cpf1. Yang M, Wei H, Wang Y, Deng J, Tang Y, Zhou L, Guo G, Tong A. Mol Ther Nucleic Acids. 2017 Sep 15;8:450-458. doi: 10.1016/j.omtn.2017.05.009. Epub 2017 May 17. PubMed |
| A Predictive Model for Selective Targeting of the Warburg Effect through GAPDH Inhibition with a Natural Product. Liberti MV, Dai Z, Wardell SE, Baccile JA, Liu X, Gao X, Baldi R, Mehrmohamadi M, Johnson MO, Madhukar NS, Shestov AA, Chio IIC, Elemento O, Rathmell JC, Schroeder FC, McDonnell DP, Locasale JW. Cell Metab. 2017 Oct 3;26(4):648-659.e8. doi: 10.1016/j.cmet.2017.08.017. Epub 2017 Sep 14. PubMed |
| Strategies to Develop Therapeutic N- and O-Hyperglycosylated Proteins. Gugliotta A, Ceaglio N, Etcheverrigaray M, Kratje R, Oggero M. Methods Mol Biol. 2018;1674:163-181. doi: 10.1007/978-1-4939-7312-5_13. PubMed |
| Novel ecto-tagged integrins reveal their trafficking in live cells. Huet-Calderwood C, Rivera-Molina F, Iwamoto DV, Kromann EB, Toomre D, Calderwood DA. Nat Commun. 2017 Sep 18;8(1):570. doi: 10.1038/s41467-017-00646-w. PubMed |
| Loss of RUNX1 is associated with aggressive lung adenocarcinomas. Ramsey J, Butnor K, Peng Z, Leclair T, van der Velden J, Stein G, Lian J, Kinsey CM. J Cell Physiol. 2018 Apr;233(4):3487-3497. doi: 10.1002/jcp.26201. Epub 2017 Nov 1. PubMed |
| Peptides derived from evolutionarily conserved domains in Beclin-1 and Beclin-2 enhance the entry of lentiviral vectors into human cells. Majdoul S, Cosette J, Seye AK, Bernard E, Frin S, Holic N, Chazal N, Briant L, Espert L, Galy A, Fenard D. J Biol Chem. 2017 Nov 10;292(45):18672-18681. doi: 10.1074/jbc.M117.800813. Epub 2017 Sep 19. PubMed |
| Bicarbonate Recycling by HIF-1-Dependent Carbonic Anhydrase Isoforms 9 and 12 Is Critical in Maintaining Intracellular pH and Viability of Nucleus Pulposus Cells. Silagi ES, Schoepflin ZR, Seifert EL, Merceron C, Schipani E, Shapiro IM, Risbud MV. J Bone Miner Res. 2018 Feb;33(2):338-355. doi: 10.1002/jbmr.3293. Epub 2017 Oct 9. PubMed |
| Correction of beta-thalassemia mutant by base editor in human embryos. Liang P, Ding C, Sun H, Xie X, Xu Y, Zhang X, Sun Y, Xiong Y, Ma W, Liu Y, Wang Y, Fang J, Liu D, Songyang Z, Zhou C, Huang J. Protein Cell. 2017 Nov;8(11):811-822. doi: 10.1007/s13238-017-0475-6. Epub 2017 Sep 23. PubMed |
| NLRP3 Phosphorylation Is an Essential Priming Event for Inflammasome Activation. Song N, Liu ZS, Xue W, Bai ZF, Wang QY, Dai J, Liu X, Huang YJ, Cai H, Zhan XY, Han QY, Wang H, Chen Y, Li HY, Li AL, Zhang XM, Zhou T, Li T. Mol Cell. 2017 Oct 5;68(1):185-197.e6. doi: 10.1016/j.molcel.2017.08.017. Epub 2017 Sep 21. PubMed |
| The Epstein-Barr virus miR-BHRF1 microRNAs regulate viral gene expression in cis. Poling BC, Price AM, Luftig MA, Cullen BR. Virology. 2017 Dec;512:113-123. doi: 10.1016/j.virol.2017.09.015. PubMed |
| Genome-Wide CRISPR Screen for Essential Cell Growth Mediators in Mutant KRAS Colorectal Cancers. Yau EH, Kummetha IR, Lichinchi G, Tang R, Zhang Y, Rana TM. Cancer Res. 2017 Nov 15;77(22):6330-6339. doi: 10.1158/0008-5472.CAN-17-2043. Epub 2017 Sep 27. PubMed |
| Transcriptional regulation of endothelial cell behavior during sprouting angiogenesis. Jeong HW, Hernandez-Rodriguez B, Kim J, Kim KP, Enriquez-Gasca R, Yoon J, Adams S, Scholer HR, Vaquerizas JM, Adams RH. Nat Commun. 2017 Sep 28;8(1):726. doi: 10.1038/s41467-017-00738-7. PubMed |
| Mitophagy Failure in Fibroblasts and iPSC-Derived Neurons of Alzheimer's Disease-Associated Presenilin 1 Mutation. Martin-Maestro P, Gargini R, A Sproul A, Garcia E, Anton LC, Noggle S, Arancio O, Avila J, Garcia-Escudero V. Front Mol Neurosci. 2017 Sep 14;10:291. doi: 10.3389/fnmol.2017.00291. eCollection 2017. PubMed |
| MYC Controls Human Pluripotent Stem Cell Fate Decisions through Regulation of Metabolic Flux. Cliff TS, Wu T, Boward BR, Yin A, Yin H, Glushka JN, Prestegaard JH, Dalton S. Cell Stem Cell. 2017 Oct 5;21(4):502-516.e9. doi: 10.1016/j.stem.2017.08.018. Epub 2017 Sep 28. PubMed |
| Amyotrophic lateral sclerosis-associated mutant SOD1 inhibits anterograde axonal transport of mitochondria by reducing Miro1 levels. Moller A, Bauer CS, Cohen RN, Webster CP, De Vos KJ. Hum Mol Genet. 2017 Dec 1;26(23):4668-4679. doi: 10.1093/hmg/ddx348. PubMed |
| MicroRNA miR-128 represses LINE-1 (L1) retrotransposition by down-regulating the nuclear import factor TNPO1. Idica A, Sevrioukov EA, Zisoulis DG, Hamdorf M, Daugaard I, Kadandale P, Pedersen IM. J Biol Chem. 2017 Dec 15;292(50):20494-20508. doi: 10.1074/jbc.M117.807677. Epub 2017 Oct 3. PubMed |
| Molecular mechanisms for enhancement of stromal cell-derived factor 1-induced chemotaxis by platelet endothelial cell adhesion molecule 1 (PECAM-1). Umezawa Y, Akiyama H, Okada K, Ishida S, Nogami A, Oshikawa G, Kurosu T, Miura O. J Biol Chem. 2017 Dec 1;292(48):19639-19655. doi: 10.1074/jbc.M117.779603. Epub 2017 Oct 3. PubMed |
| Combining confocal and atomic force microscopy to quantify single-virus binding to mammalian cell surfaces. Newton R, Delguste M, Koehler M, Dumitru AC, Laskowski PR, Muller DJ, Alsteens D. Nat Protoc. 2017 Nov;12(11):2275-2292. doi: 10.1038/nprot.2017.112. Epub 2017 Oct 5. PubMed |
| MicroRNA-7 inhibits cell proliferation of chronic myeloid leukemia and sensitizes it to imatinib in vitro. Jiang MJ, Dai JJ, Gu DN, Huang Q, Tian L. Biochem Biophys Res Commun. 2017 Dec 9;494(1-2):372-378. doi: 10.1016/j.bbrc.2017.10.001. Epub 2017 Oct 3. PubMed |
| Identification and Isolation of Cancer Stem Cells Using NANOG-EGFP Reporter System. Buczek ME, Reeder SP, Regad T. Methods Mol Biol. 2018;1692:139-148. doi: 10.1007/978-1-4939-7401-6_13. PubMed |
| ADAM8 expression in breast cancer derived brain metastases: Functional implications on MMP-9 expression and transendothelial migration in breast cancer cells. Conrad C, Gotte M, Schlomann U, Roessler M, Pagenstecher A, Anderson P, Preston J, Pruessmeyer J, Ludwig A, Li R, Kamm RD, Ritz R, Carl B, Nimsky C, Bartsch JW. Int J Cancer. 2018 Feb 15;142(4):779-791. doi: 10.1002/ijc.31090. Epub 2017 Oct 31. PubMed |
| ATF4-Induced Metabolic Reprograming Is a Synthetic Vulnerability of the p62-Deficient Tumor Stroma. Linares JF, Cordes T, Duran A, Reina-Campos M, Valencia T, Ahn CS, Castilla EA, Moscat J, Metallo CM, Diaz-Meco MT. Cell Metab. 2017 Dec 5;26(6):817-829.e6. doi: 10.1016/j.cmet.2017.09.001. Epub 2017 Oct 5. PubMed |
| Cell Cycle-Dependent Tumor Engraftment and Migration Are Enabled by Aurora-A. Chu TLH, Connell M, Zhou L, He Z, Won J, Chen H, Rahavi SMR, Mohan P, Nemirovsky O, Fotovati A, Pujana MA, Reid GSD, Nielsen TO, Pante N, Maxwell CA. Mol Cancer Res. 2018 Jan;16(1):16-31. doi: 10.1158/1541-7786.MCR-17-0417. Epub 2017 Oct 9. PubMed |
| ANO9/TMEM16J promotes tumourigenesis via EGFR and is a novel therapeutic target for pancreatic cancer. Jun I, Park HS, Piao H, Han JW, An MJ, Yun BG, Zhang X, Cha YH, Shin YK, Yook JI, Jung J, Gee HY, Park JS, Yoon DS, Jeung HC, Lee MG. Br J Cancer. 2017 Dec 5;117(12):1798-1809. doi: 10.1038/bjc.2017.355. Epub 2017 Oct 12. PubMed |
| BRCA1 or CDK12 loss sensitizes cells to CHK1 inhibitors. Paculova H, Kramara J, Simeckova S, Fedr R, Soucek K, Hylse O, Paruch K, Svoboda M, Mistrik M, Kohoutek J. Tumour Biol. 2017 Oct;39(10):1010428317727479. doi: 10.1177/1010428317727479. PubMed |
| MCT1 and MCT4 Expression and Lactate Flux Activity Increase During White and Brown Adipogenesis and Impact Adipocyte Metabolism. Petersen C, Nielsen MD, Andersen ES, Basse AL, Isidor MS, Markussen LK, Viuff BM, Lambert IH, Hansen JB, Pedersen SF. Sci Rep. 2017 Oct 12;7(1):13101. doi: 10.1038/s41598-017-13298-z. PubMed |
| Modulation of the NF-kappaB signaling pathway by the HIV-2 envelope glycoprotein and its incomplete BST-2 antagonism. Dufrasne FE, Lucchetti M, Martin A, Andre E, Dessilly G, Kabamba B, Goubau P, Ruelle J. Virology. 2018 Jan 1;513:11-16. doi: 10.1016/j.virol.2017.09.024. Epub 2017 Oct 11. PubMed |
| Merkel cell polyomavirus recruits MYCL to the EP400 complex to promote oncogenesis. Cheng J, Park DE, Berrios C, White EA, Arora R, Yoon R, Branigan T, Xiao T, Westerling T, Federation A, Zeid R, Strober B, Swanson SK, Florens L, Bradner JE, Brown M, Howley PM, Padi M, Washburn MP, DeCaprio JA. PLoS Pathog. 2017 Oct 13;13(10):e1006668. doi: 10.1371/journal.ppat.1006668. eCollection 2017 Oct. PubMed |
ANGPTL8 promotes the ability of ANGPTL3 to bind and inhibit lipoprotein lipase.
Chi X, Britt EC, Shows HW, Hjelmaas AJ, Shetty SK, Cushing EM, Li W, Dou A, Zhang R, Davies BSJ.
Mol Metab. 2017 Oct;6(10):1137-1149. doi: 10.1016/j.molmet.2017.06.014. Epub 2017 Jun 29.
PubMed
Associated Plasmids |
| Widespread Post-transcriptional Attenuation of Genomic Copy-Number Variation in Cancer. Goncalves E, Fragoulis A, Garcia-Alonso L, Cramer T, Saez-Rodriguez J, Beltrao P. Cell Syst. 2017 Oct 25;5(4):386-398.e4. doi: 10.1016/j.cels.2017.08.013. Epub 2017 Oct 11. PubMed |
| Genome-Nuclear Lamina Interactions Regulate Cardiac Stem Cell Lineage Restriction. Poleshko A, Shah PP, Gupta M, Babu A, Morley MP, Manderfield LJ, Ifkovits JL, Calderon D, Aghajanian H, Sierra-Pagan JE, Sun Z, Wang Q, Li L, Dubois NC, Morrisey EE, Lazar MA, Smith CL, Epstein JA, Jain R. Cell. 2017 Oct 19;171(3):573-587.e14. doi: 10.1016/j.cell.2017.09.018. Epub 2017 Oct 12. PubMed |
CRISPR/Cas9-mediated gene knockout is insensitive to target copy number but is dependent on guide RNA potency and Cas9/sgRNA threshold expression level.
Yuen G, Khan FJ, Gao S, Stommel JM, Batchelor E, Wu X, Luo J.
Nucleic Acids Res. 2017 Nov 16;45(20):12039-12053. doi: 10.1093/nar/gkx843.
PubMed
Associated Plasmids |
| TRIM29 promotes DNA virus infections by inhibiting innate immune response. Xing J, Zhang A, Zhang H, Wang J, Li XC, Zeng MS, Zhang Z. Nat Commun. 2017 Oct 16;8(1):945. doi: 10.1038/s41467-017-00101-w. PubMed |
| Gene delivery of hypoxia-inducible VEGF targeting collagen effectively improves cardiac function after myocardial infarction. Xia JB, Wu HY, Lai BL, Zheng L, Zhou DC, Chang ZS, Mao CZ, Liu GH, Park KS, Zhao H, Kim SK, Song GH, Cai DQ, Qi XF. Sci Rep. 2017 Oct 16;7(1):13273. doi: 10.1038/s41598-017-13547-1. PubMed |
| Toll-Like Receptor 8 Is a Major Sensor of Group B Streptococcus But Not Escherichia coli in Human Primary Monocytes and Macrophages. Ehrnstrom B, Beckwith KS, Yurchenko M, Moen SH, Kojen JF, Lentini G, Teti G, Damas JK, Espevik T, Stenvik J. Front Immunol. 2017 Oct 3;8:1243. doi: 10.3389/fimmu.2017.01243. eCollection 2017. PubMed |
| MANF Promotes Differentiation and Migration of Neural Progenitor Cells with Potential Neural Regenerative Effects in Stroke. Tseng KY, Anttila JE, Khodosevich K, Tuominen RK, Lindahl M, Domanskyi A, Airavaara M. Mol Ther. 2018 Jan 3;26(1):238-255. doi: 10.1016/j.ymthe.2017.09.019. Epub 2017 Sep 21. PubMed |
| Assembly of the WHIP-TRIM14-PPP6C Mitochondrial Complex Promotes RIG-I-Mediated Antiviral Signaling. Tan P, He L, Cui J, Qian C, Cao X, Lin M, Zhu Q, Li Y, Xing C, Yu X, Wang HY, Wang RF. Mol Cell. 2017 Oct 19;68(2):293-307.e5. doi: 10.1016/j.molcel.2017.09.035. PubMed |
| CpG oligodeoxynucleotide preconditioning improves cardiac function after myocardial infarction via modulation of energy metabolism and angiogenesis. Zhou DC, Su YH, Jiang FQ, Xia JB, Wu HY, Chang ZS, Peng WT, Song GH, Park KS, Kim SK, Cai DQ, Zheng L, Qi XF. J Cell Physiol. 2018 May;233(5):4245-4257. doi: 10.1002/jcp.26243. Epub 2017 Nov 24. PubMed |
| TGF-beta receptor I/II trafficking and signaling at primary cilia are inhibited by ceramide to attenuate cell migration and tumor metastasis. Gencer S, Oleinik N, Kim J, Panneer Selvam S, De Palma R, Dany M, Nganga R, Thomas RJ, Senkal CE, Howe PH, Ogretmen B. Sci Signal. 2017 Oct 24;10(502). pii: 10/502/eaam7464. doi: 10.1126/scisignal.aam7464. PubMed |
| UTX-guided neural crest function underlies craniofacial features of Kabuki syndrome. Shpargel KB, Starmer J, Wang C, Ge K, Magnuson T. Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):E9046-E9055. doi: 10.1073/pnas.1705011114. Epub 2017 Oct 9. PubMed |
Intercellular mRNA trafficking via membrane nanotube-like extensions in mammalian cells.
Haimovich G, Ecker CM, Dunagin MC, Eggan E, Raj A, Gerst JE, Singer RH.
Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):E9873-E9882. doi: 10.1073/pnas.1706365114. Epub 2017 Oct 24.
PubMed
Associated Plasmids |
| Design, Assembly, Production, and Transfection of Synthetic Modified mRNA. Oh S, Kessler JA. Methods. 2018 Jan 15;133:29-43. doi: 10.1016/j.ymeth.2017.10.008. Epub 2017 Nov 7. PubMed |
| Class III phosphatidylinositol-3-OH kinase controls epithelial integrity through endosomal LKB1 regulation. O'Farrell F, Lobert VH, Sneeggen M, Jain A, Katheder NS, Wenzel EM, Schultz SW, Tan KW, Brech A, Stenmark H, Rusten TE. Nat Cell Biol. 2017 Dec;19(12):1412-1423. doi: 10.1038/ncb3631. Epub 2017 Oct 30. PubMed |
| APC downregulated 1 inhibits breast cancer cell invasion by inhibiting the canonical WNT signaling pathway. Cho SG. Oncol Lett. 2017 Oct;14(4):4845-4852. doi: 10.3892/ol.2017.6801. Epub 2017 Aug 23. PubMed |
| A vimentin binding small molecule leads to mitotic disruption in mesenchymal cancers. Bollong MJ, Pietila M, Pearson AD, Sarkar TR, Ahmad I, Soundararajan R, Lyssiotis CA, Mani SA, Schultz PG, Lairson LL. Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):E9903-E9912. doi: 10.1073/pnas.1716009114. Epub 2017 Oct 30. PubMed |
| StUbEx PLUS-A Modified Stable Tagged Ubiquitin Exchange System for Peptide Level Purification and In-Depth Mapping of Ubiquitination Sites. Akimov V, Olsen LCB, Hansen SVF, Barrio-Hernandez I, Puglia M, Jensen SS, Solov'yov IA, Kratchmarova I, Blagoev B. J Proteome Res. 2018 Jan 5;17(1):296-304. doi: 10.1021/acs.jproteome.7b00566. Epub 2017 Nov 1. PubMed |
| Involvement of Zizimin2/3 in the age-related defect of peritoneal B-1a cells as a source of anti-bacterial IgM. Sakamoto A, Matsuda T, Kawaguchi K, Takaoka A, Maruyama M. Int Immunol. 2017 Nov 1;29(9):431-438. doi: 10.1093/intimm/dxx054. PubMed |
| TGF-beta-Induced Quiescence Mediates Chemoresistance of Tumor-Propagating Cells in Squamous Cell Carcinoma. Brown JA, Yonekubo Y, Hanson N, Sastre-Perona A, Basin A, Rytlewski JA, Dolgalev I, Meehan S, Tsirigos A, Beronja S, Schober M. Cell Stem Cell. 2017 Nov 2;21(5):650-664.e8. doi: 10.1016/j.stem.2017.10.001. PubMed |
| In Vivo Survival of Human Endometrial Mesenchymal Stem Cells Transplanted Under the Kidney Capsule of Immunocompromised Mice. Gurung S, Deane JA, Darzi S, Werkmeister JA, Gargett CE. Stem Cells Dev. 2018 Jan 1;27(1):35-43. doi: 10.1089/scd.2017.0177. Epub 2017 Dec 5. PubMed |
| Nuclear TRIM25 Specifically Targets Influenza Virus Ribonucleoproteins to Block the Onset of RNA Chain Elongation. Meyerson NR, Zhou L, Guo YR, Zhao C, Tao YJ, Krug RM, Sawyer SL. Cell Host Microbe. 2017 Nov 8;22(5):627-638.e7. doi: 10.1016/j.chom.2017.10.003. Epub 2017 Nov 5. PubMed |
| STK38L kinase ablation promotes loss of cell viability in a subset of KRAS-dependent pancreatic cancer cell lines. Grant TJ, Mehta AK, Gupta A, Sharif AAD, Arora KS, Deshpande V, Ting DT, Bardeesy N, Ganem NJ, Hergovich A, Singh A. Oncotarget. 2017 Sep 11;8(45):78556-78572. doi: 10.18632/oncotarget.20833. eCollection 2017 Oct 3. PubMed |
| Multitarget inhibition by four tandem shRNAs embedded in homo or heteromiRNA backbones. Du X, Cai Y, Xi W, Zhang R, Jia L, Yang A, Zhao J, Yan B. Mol Med Rep. 2018 Jan;17(1):307-314. doi: 10.3892/mmr.2017.7854. Epub 2017 Oct 20. PubMed |
| Maternal embryonic leucine zipper kinase is a novel target for proliferation-associated high-risk myeloma. Bolomsky A, Heusschen R, Schlangen K, Stangelberger K, Muller J, Schreiner W, Zojer N, Caers J, Ludwig H. Haematologica. 2018 Feb;103(2):325-335. doi: 10.3324/haematol.2017.172973. Epub 2017 Nov 9. PubMed |
A Map of Human Mitochondrial Protein Interactions Linked to Neurodegeneration Reveals New Mechanisms of Redox Homeostasis and NF-kappaB Signaling.
Malty RH, Aoki H, Kumar A, Phanse S, Amin S, Zhang Q, Minic Z, Goebels F, Musso G, Wu Z, Abou-Tok H, Meyer M, Deineko V, Kassir S, Sidhu V, Jessulat M, Scott NE, Xiong X, Vlasblom J, Prasad B, Foster LJ, Alberio T, Garavaglia B, Yu H, Bader GD, Nakamura K, Parkinson J, Babu M.
Cell Syst. 2017 Nov 7. pii: S2405-4712(17)30447-7. doi: 10.1016/j.cels.2017.10.010.
PubMed
Associated Plasmids |
| Deguelin, an Aurora B Kinase Inhibitor, Exhibits Potent Anti-Tumor Effect in Human Esophageal Squamous Cell Carcinoma. Yu X, Liang Q, Liu W, Zhou L, Li W, Liu H. EBioMedicine. 2017 Dec;26:100-111. doi: 10.1016/j.ebiom.2017.10.030. Epub 2017 Nov 3. PubMed |
| Nonimmune cells equipped with T-cell-receptor-like signaling for cancer cell ablation. Kojima R, Scheller L, Fussenegger M. Nat Chem Biol. 2018 Jan;14(1):42-49. doi: 10.1038/nchembio.2498. Epub 2017 Nov 13. PubMed |
| Loss of E-cadherin provides tolerance to centrosome amplification in epithelial cancer cells. Rhys AD, Monteiro P, Smith C, Vaghela M, Arnandis T, Kato T, Leitinger B, Sahai E, McAinsh A, Charras G, Godinho SA. J Cell Biol. 2018 Jan 2;217(1):195-209. doi: 10.1083/jcb.201704102. Epub 2017 Nov 13. PubMed |
| Chemokine Signaling Facilitates Early-Stage Breast Cancer Survival and Invasion through Fibroblast-Dependent Mechanisms. Brummer G, Acevedo DS, Hu Q, Portsche M, Fang WB, Yao M, Zinda B, Myers M, Alvarez N, Fields P, Hong Y, Behbod F, Cheng N. Mol Cancer Res. 2018 Feb;16(2):296-308. doi: 10.1158/1541-7786.MCR-17-0308. Epub 2017 Nov 13. PubMed |
| C/EBPbeta mediates RNA polymerase III-driven transcription of oncomiR-138 in malignant gliomas. Di Pascale F, Nama S, Muhuri M, Quah S, Ismail HM, Chan XHD, Sundaram GM, Ramalingam R, Burke B, Sampath P. Nucleic Acids Res. 2018 Jan 9;46(1):336-349. doi: 10.1093/nar/gkx1105. PubMed |
| JNK Promotes Epithelial Cell Anoikis by Transcriptional and Post-translational Regulation of BH3-Only Proteins. Girnius N, Davis RJ. Cell Rep. 2017 Nov 14;21(7):1910-1921. doi: 10.1016/j.celrep.2017.10.067. PubMed |
| Salt bridges gate alpha-catenin activation at intercellular junctions. Barrick S, Li J, Kong X, Ray A, Tajkhorshid E, Leckband D. Mol Biol Cell. 2018 Jan 15;29(2):111-122. doi: 10.1091/mbc.E17-03-0168. Epub 2017 Nov 15. PubMed |
| BCAT1 restricts alphaKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation. Raffel S, Falcone M, Kneisel N, Hansson J, Wang W, Lutz C, Bullinger L, Poschet G, Nonnenmacher Y, Barnert A, Bahr C, Zeisberger P, Przybylla A, Sohn M, Tonjes M, Erez A, Adler L, Jensen P, Scholl C, Frohling S, Cocciardi S, Wuchter P, Thiede C, Florcken A, Westermann J, Ehninger G, Lichter P, Hiller K, Hell R, Herrmann C, Ho AD, Krijgsveld J, Radlwimmer B, Trumpp A. Nature. 2017 Nov 16;551(7680):384-388. doi: 10.1038/nature24294. Epub 2017 Nov 8. PubMed |
| Cre-dependent Cas9-expressing pigs enable efficient in vivo genome editing. Wang K, Jin Q, Ruan D, Yang Y, Liu Q, Wu H, Zhou Z, Ouyang Z, Liu Z, Zhao Y, Zhao B, Zhang Q, Peng J, Lai C, Fan N, Liang Y, Lan T, Li N, Wang X, Wang X, Fan Y, Doevendans PA, Sluijter JPG, Liu P, Li X, Lai L. Genome Res. 2017 Dec;27(12):2061-2071. doi: 10.1101/gr.222521.117. Epub 2017 Nov 16. PubMed |
| Harnessing BET Inhibitor Sensitivity Reveals AMIGO2 as a Melanoma Survival Gene. Fontanals-Cirera B, Hasson D, Vardabasso C, Di Micco R, Agrawal P, Chowdhury A, Gantz M, de Pablos-Aragoneses A, Morgenstern A, Wu P, Filipescu D, Valle-Garcia D, Darvishian F, Roe JS, Davies MA, Vakoc CR, Hernando E, Bernstein E. Mol Cell. 2017 Nov 16;68(4):731-744.e9. doi: 10.1016/j.molcel.2017.11.004. PubMed |
A Method for the Acute and Rapid Degradation of Endogenous Proteins.
Clift D, McEwan WA, Labzin LI, Konieczny V, Mogessie B, James LC, Schuh M.
Cell. 2017 Nov 13. pii: S0092-8674(17)31255-2. doi: 10.1016/j.cell.2017.10.033.
PubMed
Associated Plasmids |
| Glutaminase inhibition in multiple myeloma induces apoptosis via MYC degradation. Effenberger M, Bommert KS, Kunz V, Kruk J, Leich E, Rudelius M, Bargou R, Bommert K. Oncotarget. 2017 Aug 24;8(49):85858-85867. doi: 10.18632/oncotarget.20691. eCollection 2017 Oct 17. PubMed |
| Display of the Albumin-Binding Domain in the Envelope Improves Lentiviral Vector Bioavailability. Garaulet G, Lazcano JJ, Alarcon H, de Frutos S, Martinez-Torrecuadrada JL, Rodriguez A. Hum Gene Ther Methods. 2017 Dec;28(6):340-351. doi: 10.1089/hgtb.2017.057. PubMed |
| 3D collagen architecture induces a conserved migratory and transcriptional response linked to vasculogenic mimicry. Velez DO, Tsui B, Goshia T, Chute CL, Han A, Carter H, Fraley SI. Nat Commun. 2017 Nov 21;8(1):1651. doi: 10.1038/s41467-017-01556-7. PubMed |
| Nicotinic Acetylcholine Receptor Subtype Alpha-9 Mediates Triple-Negative Breast Cancers Based on a Spontaneous Pulmonary Metastasis Mouse Model. Huang LC, Lin CL, Qiu JZ, Lin CY, Hsu KW, Tam KW, Lee JY, Yang JM, Lee CH. Front Cell Neurosci. 2017 Nov 3;11:336. doi: 10.3389/fncel.2017.00336. eCollection 2017. PubMed |
| Regulatory T Cell Migration Is Dependent on Glucokinase-Mediated Glycolysis. Kishore M, Cheung KCP, Fu H, Bonacina F, Wang G, Coe D, Ward EJ, Colamatteo A, Jangani M, Baragetti A, Matarese G, Smith DM, Haas R, Mauro C, Wraith DC, Okkenhaug K, Catapano AL, De Rosa V, Norata GD, Marelli-Berg FM. Immunity. 2017 Nov 21;47(5):875-889.e10. doi: 10.1016/j.immuni.2017.10.017. PubMed |
| Foot-and-mouth disease virus capsid protein VP2 activates the cellular EIF2S1-ATF4 pathway and induces autophagy via HSPB1. Sun P, Zhang S, Qin X, Chang X, Cui X, Li H, Zhang S, Gao H, Wang P, Zhang Z, Luo J, Li Z. Autophagy. 2018;14(2):336-346. doi: 10.1080/15548627.2017.1405187. Epub 2018 Jan 29. PubMed |
| Vacuolar protein sorting 13C is a novel lipid droplet protein that inhibits lipolysis in brown adipocytes. Ramseyer VD, Kimler VA, Granneman JG. Mol Metab. 2018 Jan;7:57-70. doi: 10.1016/j.molmet.2017.10.014. Epub 2017 Nov 12. PubMed |
| Migration against the direction of flow is LFA-1-dependent in human hematopoietic stem and progenitor cells. Buffone A Jr, Anderson NR, Hammer DA. J Cell Sci. 2018 Jan 10;131(1). pii: jcs.205575. doi: 10.1242/jcs.205575. PubMed |
| The ATPase activity of Asna1/TRC40 is required for pancreatic progenitor cell survival. Norlin S, Parekh V, Edlund H. Development. 2018 Jan 3;145(1). pii: dev.154468. doi: 10.1242/dev.154468. PubMed |
| Smad4 SUMOylation is essential for memory formation through upregulation of the skeletal myopathy gene TPM2. Hsu WL, Ma YL, Liu YC, Lee EHY. BMC Biol. 2017 Nov 28;15(1):112. doi: 10.1186/s12915-017-0452-9. PubMed |
| Cardiopatch platform enables maturation and scale-up of human pluripotent stem cell-derived engineered heart tissues. Shadrin IY, Allen BW, Qian Y, Jackman CP, Carlson AL, Juhas ME, Bursac N. Nat Commun. 2017 Nov 28;8(1):1825. doi: 10.1038/s41467-017-01946-x. PubMed |
| p53 promotes AKT and SP1-dependent metabolism through the pentose phosphate pathway that inhibits apoptosis in response to Nutlin-3a. Duan L, Perez RE, Chen L, Blatter LA, Maki CG. J Mol Cell Biol. 2018 Aug 1;10(4):331-340. doi: 10.1093/jmcb/mjx051. PubMed |
| Crosstalk between developing vasculature and optogenetically engineered skeletal muscle improves muscle contraction and angiogenesis. Osaki T, Sivathanu V, Kamm RD. Biomaterials. 2018 Feb;156:65-76. doi: 10.1016/j.biomaterials.2017.11.041. Epub 2017 Nov 25. PubMed |
| Spindle associated membrane protein 1 (Samp1) is required for the differentiation of muscle cells. Jafferali MH, Figueroa RA, Hasan M, Hallberg E. Sci Rep. 2017 Nov 30;7(1):16655. doi: 10.1038/s41598-017-16746-y. PubMed |
| Protein-lysine methyltransferases G9a and GLP1 promote responses to DNA damage. Ginjala V, Rodriguez-Colon L, Ganguly B, Gangidi P, Gallina P, Al-Hraishawi H, Kulkarni A, Tang J, Gheeya J, Simhadri S, Yao M, Xia B, Ganesan S. Sci Rep. 2017 Nov 30;7(1):16613. doi: 10.1038/s41598-017-16480-5. PubMed |
| The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages. Evavold CL, Ruan J, Tan Y, Xia S, Wu H, Kagan JC. Immunity. 2018 Jan 16;48(1):35-44.e6. doi: 10.1016/j.immuni.2017.11.013. Epub 2017 Nov 28. PubMed |
| Slower Dynamics and Aged Mitochondria in Sporadic Alzheimer's Disease. Martin-Maestro P, Gargini R, Garcia E, Perry G, Avila J, Garcia-Escudero V. Oxid Med Cell Longev. 2017;2017:9302761. doi: 10.1155/2017/9302761. Epub 2017 Oct 19. PubMed |
| A population of innate myelolymphoblastoid effector cell expanded by inactivation of mTOR complex 1 in mice. Tang F, Zhang P, Ye P, Lazarski CA, Wu Q, Bergin IL, Bender TP, Hall MN, Cui Y, Zhang L, Jiang T, Liu Y, Zheng P. Elife. 2017 Dec 5;6. pii: 32497. doi: 10.7554/eLife.32497. PubMed |
| Inhibition of ID1-BMPR2 Intrinsic Signaling Sensitizes Glioma Stem Cells to Differentiation Therapy. Jin X, Jin X, Kim LJY, Dixit D, Jeon HY, Kim EJ, Kim JK, Lee SY, Yin J, Rich JN, Kim H. Clin Cancer Res. 2018 Jan 15;24(2):383-394. doi: 10.1158/1078-0432.CCR-17-1529. Epub 2017 Dec 5. PubMed |
| Comprehensive Analysis of Cytomegalovirus pp65 Antigen-Specific CD8(+) T Cell Responses According to Human Leukocyte Antigen Class I Allotypes and Intraindividual Dominance. Hyun SJ, Sohn HJ, Lee HJ, Lee SD, Kim S, Sohn DH, Hong CH, Choi H, Cho HI, Kim TG. Front Immunol. 2017 Nov 21;8:1591. doi: 10.3389/fimmu.2017.01591. eCollection 2017. PubMed |
| Wnt/beta-catenin Signaling Pathway Regulates Specific lncRNAs That Impact Dermal Fibroblasts and Skin Fibrosis. Mullin NK, Mallipeddi NV, Hamburg-Shields E, Ibarra B, Khalil AM, Atit RP. Front Genet. 2017 Nov 21;8:183. doi: 10.3389/fgene.2017.00183. eCollection 2017. PubMed |
| Chemical hypoxia-induced integrated stress response activation in oligodendrocytes is mediated by the transcription factor nuclear factor (erythroid-derived 2)-like 2 (NRF2). Teske N, Liessem A, Fischbach F, Clarner T, Beyer C, Wruck C, Fragoulis A, Tauber SC, Victor M, Kipp M. J Neurochem. 2018 Feb;144(3):285-301. doi: 10.1111/jnc.14270. Epub 2018 Jan 5. PubMed |
| LDB2 inhibits proliferation and migration in liver cancer cells by abrogating HEY1 expression. Yu H, Jia R, Zhao L, Song S, Gu J, Zhang H. Oncotarget. 2017 Oct 10;8(55):94440-94449. doi: 10.18632/oncotarget.21772. eCollection 2017 Nov 7. PubMed |
| Manufacture of Third-Generation Lentivirus for Preclinical Use, with Process Development Considerations for Translation to Good Manufacturing Practice. Gandara C, Affleck V, Stoll EA. Hum Gene Ther Methods. 2018 Feb;29(1):1-15. doi: 10.1089/hgtb.2017.098. Epub 2018 Jan 24. PubMed |
| Tetraspanin CD63 Bridges Autophagic and Endosomal Processes To Regulate Exosomal Secretion and Intracellular Signaling of Epstein-Barr Virus LMP1 Hurwitz SN, Cheerathodi MR, Nkosi D, York SB, Meckes DG Jr. J Virol. 2018 Feb 12;92(5). pii: JVI.01969-17. doi: 10.1128/JVI.01969-17. Print 2018 Mar 1. PubMed |
| Requirement of Treg-intrinsic CTLA4/PKCeta signaling pathway for suppressing tumor immunity. Pedros C, Canonigo-Balancio AJ, Kong KF, Altman A. JCI Insight. 2017 Dec 7;2(23). pii: 95692. doi: 10.1172/jci.insight.95692. PubMed |
| Cytoplasmic Linker Protein CLIP170 Negatively Regulates TLR4 Signaling by Targeting the TLR Adaptor Protein TIRAP. Jakka P, Bhargavi B, Namani S, Murugan S, Splitter G, Radhakrishnan G. J Immunol. 2018 Jan 15;200(2):704-714. doi: 10.4049/jimmunol.1601559. Epub 2017 Dec 8. PubMed |
| Next-Generation Sequencing of Genome-Wide CRISPR Screens. Yau EH, Rana TM. Methods Mol Biol. 2018;1712:203-216. doi: 10.1007/978-1-4939-7514-3_13. PubMed |
YY1 Is a Structural Regulator of Enhancer-Promoter Loops.
Weintraub AS, Li CH, Zamudio AV, Sigova AA, Hannett NM, Day DS, Abraham BJ, Cohen MA, Nabet B, Buckley DL, Guo YE, Hnisz D, Jaenisch R, Bradner JE, Gray NS, Young RA.
Cell. 2017 Dec 14;171(7):1573-1588.e28. doi: 10.1016/j.cell.2017.11.008. Epub 2017 Dec 7.
PubMed
Associated Plasmids |
| Lysyl oxidase-like 3 is required for melanoma cell survival by maintaining genomic stability. Santamaria PG, Floristan A, Fontanals-Cirera B, Vazquez-Naharro A, Santos V, Morales S, Yuste L, Peinado H, Garcia-Gomez A, Portillo F, Hernando E, Cano A. Cell Death Differ. 2017 Dec 11. pii: 10.1038/s41418-017-0030-2. doi: 10.1038/s41418-017-0030-2. PubMed |
| Synthetic Lethality of Combined Bcl-2 Inhibition and p53 Activation in AML: Mechanisms and Superior Antileukemic Efficacy. Pan R, Ruvolo V, Mu H, Leverson JD, Nichols G, Reed JC, Konopleva M, Andreeff M. Cancer Cell. 2017 Dec 11;32(6):748-760.e6. doi: 10.1016/j.ccell.2017.11.003. PubMed |
| Probing the requirement for CD38 in retinoic acid-induced HL-60 cell differentiation with a small molecule dimerizer and genetic knockout. MacDonald RJ, Shrimp JH, Jiang H, Zhang L, Lin H, Yen A. Sci Rep. 2017 Dec 12;7(1):17406. doi: 10.1038/s41598-017-17720-4. PubMed |
| Interaction of porcine reproductive and respiratory syndrome virus proteins with SUMO-conjugating enzyme reveals the SUMOylation of nucleocapsid protein. Wang C, Zeng N, Liu S, Miao Q, Zhou L, Ge X, Han J, Guo X, Yang H. PLoS One. 2017 Dec 13;12(12):e0189191. doi: 10.1371/journal.pone.0189191. eCollection 2017. PubMed |
| Primary Ovarian Insufficiency and Azoospermia in Carriers of a Homozygous PSMC3IP Stop Gain Mutation. Al-Agha AE, Ahmed IA, Nuebel E, Moriwaki M, Moore B, Peacock KA, Mosbruger T, Neklason DW, Jorde LB, Yandell M, Welt CK. J Clin Endocrinol Metab. 2018 Feb 1;103(2):555-563. doi: 10.1210/jc.2017-01966. PubMed |
| Dual repression of endocytic players by ESCC microRNAs and the Polycomb complex regulates mouse embryonic stem cell pluripotency. Mote RD, Mahajan G, Padmanabhan A, Ambati R, Subramanyam D. Sci Rep. 2017 Dec 14;7(1):17572. doi: 10.1038/s41598-017-17828-7. PubMed |
| Virus stamping for targeted single-cell infection in vitro and in vivo. Schubert R, Trenholm S, Balint K, Kosche G, Cowan CS, Mohr MA, Munz M, Martinez-Martin D, Flaschner G, Newton R, Krol J, Scherf BG, Yonehara K, Wertz A, Ponti A, Ghanem A, Hillier D, Conzelmann KK, Muller DJ, Roska B. Nat Biotechnol. 2018 Jan;36(1):81-88. doi: 10.1038/nbt.4034. Epub 2017 Dec 18. PubMed |
| Oncogenic RAS-Induced Perinuclear Signaling Complexes Requiring KSR1 Regulate Signal Transmission to Downstream Targets. Basu SK, Lee S, Salotti J, Basu S, Sakchaisri K, Xiao Z, Walia V, Westlake CJ, Morrison DK, Johnson PF. Cancer Res. 2018 Feb 15;78(4):891-908. doi: 10.1158/0008-5472.CAN-17-2353. Epub 2017 Dec 19. PubMed |
| Protective role of FKBP51 in calcium entry-induced endothelial barrier disruption. Hamilton CL, Kadeba PI, Vasauskas AA, Solodushko V, McClinton AK, Alexeyev M, Scammell JG, Cioffi DL. Pulm Circ. 2018 Jan-Mar;8(1):2045893217749987. doi: 10.1177/2045893217749987. Epub 2017 Dec 20. PubMed |
| ABR, a novel inducer of transcription factor C/EBPalpha, contributes to myeloid differentiation and is a favorable prognostic factor in acute myeloid leukemia. Namasu CY, Katzerke C, Brauer-Hartmann D, Wurm AA, Gerloff D, Hartmann JU, Schwind S, Muller-Tidow C, Hilger N, Fricke S, Christopeit M, Niederwieser D, Behre G. Oncotarget. 2017 Oct 26;8(61):103626-103639. doi: 10.18632/oncotarget.22093. eCollection 2017 Nov 28. PubMed |
| Emerging Alphaviruses Are Sensitive to Cellular States Induced by a Novel Small-Molecule Agonist of the STING Pathway. Gall B, Pryke K, Abraham J, Mizuno N, Botto S, Sali TM, Broeckel R, Haese N, Nilsen A, Placzek A, Morrison T, Heise M, Streblow D, DeFilippis V. J Virol. 2018 Feb 26;92(6). pii: JVI.01913-17. doi: 10.1128/JVI.01913-17. Print 2018 Mar 15. PubMed |
| Genomic and Proteomic Resolution of Heterochromatin and Its Restriction of Alternate Fate Genes. Becker JS, McCarthy RL, Sidoli S, Donahue G, Kaeding KE, He Z, Lin S, Garcia BA, Zaret KS. Mol Cell. 2017 Dec 21;68(6):1023-1037.e15. doi: 10.1016/j.molcel.2017.11.030. PubMed |
| AP-1 Transcription Factors and the BAF Complex Mediate Signal-Dependent Enhancer Selection. Vierbuchen T, Ling E, Cowley CJ, Couch CH, Wang X, Harmin DA, Roberts CWM, Greenberg ME. Mol Cell. 2017 Dec 21;68(6):1067-1082.e12. doi: 10.1016/j.molcel.2017.11.026. PubMed |
| TRAIL induces apoptosis but not necroptosis in colorectal and pancreatic cancer cells preferentially via the TRAIL-R2/DR5 receptor. Nahacka Z, Svadlenka J, Peterka M, Ksandrova M, Benesova S, Neuzil J, Andera L. Biochim Biophys Acta. 2018 Mar;1865(3):522-531. doi: 10.1016/j.bbamcr.2017.12.006. Epub 2017 Dec 24. PubMed |
| Reversible dual inhibitor against G9a and DNMT1 improves human iPSC derivation enhancing MET and facilitating transcription factor engagement to the genome. Rodriguez-Madoz JR, San Jose-Eneriz E, Rabal O, Zapata-Linares N, Miranda E, Rodriguez S, Porciuncula A, Vilas-Zornoza A, Garate L, Segura V, Guruceaga E, Agirre X, Oyarzabal J, Prosper F. PLoS One. 2017 Dec 27;12(12):e0190275. doi: 10.1371/journal.pone.0190275. eCollection 2017. PubMed |
| A Targeted RNAi Screen Identifies Endocytic Trafficking Factors That Control GLP-1 Receptor Signaling in Pancreatic beta-Cells. Buenaventura T, Kanda N, Douzenis PC, Jones B, Bloom SR, Chabosseau P, Correa IR Jr., Bosco D, Piemonti L, Marchetti P, Johnson PR, Shapiro AMJ, Rutter GA, Tomas A. Diabetes. 2018 Mar;67(3):385-399. doi: 10.2337/db17-0639. Epub 2017 Dec 28. PubMed |
| The role of host DNA ligases in hepadnavirus covalently closed circular DNA formation. Long Q, Yan R, Hu J, Cai D, Mitra B, Kim ES, Marchetti A, Zhang H, Wang S, Liu Y, Huang A, Guo H. PLoS Pathog. 2017 Dec 29;13(12):e1006784. doi: 10.1371/journal.ppat.1006784. eCollection 2017 Dec. PubMed |
| The p38 Mitogen-Activated Protein Kinase Critically Regulates Human Keratinocyte Inflammasome Activation. Fenini G, Grossi S, Gehrke S, Beer HD, Satoh TK, Contassot E, French LE. J Invest Dermatol. 2018 Jun;138(6):1380-1390. doi: 10.1016/j.jid.2017.10.037. Epub 2017 Dec 26. PubMed |
| CRISPR Screens Uncover Genes that Regulate Target Cell Sensitivity to the Morphogen Sonic Hedgehog. Pusapati GV, Kong JH, Patel BB, Krishnan A, Sagner A, Kinnebrew M, Briscoe J, Aravind L, Rohatgi R. Dev Cell. 2018 Jan 8;44(1):113-129.e8. doi: 10.1016/j.devcel.2017.12.003. Epub 2017 Dec 28. PubMed |
| Neurocan, an extracellular chondroitin sulfate proteoglycan, stimulates neuroblastoma cells to promote malignant phenotypes. Su Z, Kishida S, Tsubota S, Sakamoto K, Cao D, Kiyonari S, Ohira M, Kamijo T, Narita A, Xu Y, Takahashi Y, Kadomatsu K. Oncotarget. 2017 Nov 15;8(63):106296-106310. doi: 10.18632/oncotarget.22435. eCollection 2017 Dec 5. PubMed |
| Combined venetoclax and alvocidib in acute myeloid leukemia. Bogenberger J, Whatcott C, Hansen N, Delman D, Shi CX, Kim W, Haws H, Soh K, Lee YS, Peterson P, Siddiqui-Jain A, Weitman S, Stewart K, Bearss D, Mesa R, Warner S, Tibes R. Oncotarget. 2017 Nov 3;8(63):107206-107222. doi: 10.18632/oncotarget.22284. eCollection 2017 Dec 5. PubMed |
| Ultrawidefield microscope for high-speed fluorescence imaging and targeted optogenetic stimulation. Werley CA, Chien MP, Cohen AE. Biomed Opt Express. 2017 Nov 29;8(12):5794-5813. doi: 10.1364/BOE.8.005794. eCollection 2017 Dec 1. PubMed |
| A Role for Myosin Va in Human Cytomegalovirus Nuclear Egress. Wilkie AR, Sharma M, Pesola JM, Ericsson M, Fernandez R, Coen DM. J Virol. 2018 Feb 26;92(6). pii: JVI.01849-17. doi: 10.1128/JVI.01849-17. Print 2018 Mar 15. PubMed |
| Colonoscopy-based colorectal cancer modeling in mice with CRISPR-Cas9 genome editing and organoid transplantation. Roper J, Tammela T, Akkad A, Almeqdadi M, Santos SB, Jacks T, Yilmaz OH. Nat Protoc. 2018 Feb;13(2):217-234. doi: 10.1038/nprot.2017.136. Epub 2018 Jan 4. PubMed |
| Importin alpha1 is required for nuclear import of herpes simplex virus proteins and capsid assembly in fibroblasts and neurons. Dohner K, Ramos-Nascimento A, Bialy D, Anderson F, Hickford-Martinez A, Rother F, Koithan T, Rudolph K, Buch A, Prank U, Binz A, Hugel S, Lebbink RJ, Hoeben RC, Hartmann E, Bader M, Bauerfeind R, Sodeik B. PLoS Pathog. 2018 Jan 5;14(1):e1006823. doi: 10.1371/journal.ppat.1006823. eCollection 2018 Jan. PubMed |
| Tousled-like kinase 1 is a negative regulator of core transcription factors in murine embryonic stem cells. Lee J, Kim MS, Park SH, Jang YK. Sci Rep. 2018 Jan 10;8(1):334. doi: 10.1038/s41598-017-18628-9. PubMed |
| The interactome of EBV LMP1 evaluated by proximity-based BioID approach. Rider MA, Cheerathodi MR, Hurwitz SN, Nkosi D, Howell LA, Tremblay DC, Liu X, Zhu F, Meckes DG Jr. Virology. 2018 Mar;516:55-70. doi: 10.1016/j.virol.2017.12.033. Epub 2018 Jan 9. PubMed |
| The HIV-1 accessory proteins Nef and Vpu downregulate total and cell surface CD28 in CD4(+) T cells. Pawlak EN, Dirk BS, Jacob RA, Johnson AL, Dikeakos JD. Retrovirology. 2018 Jan 12;15(1):6. doi: 10.1186/s12977-018-0388-3. PubMed |
| Frequent overexpression of AMAP1, an Arf6 effector in cell invasion, is characteristic of the MMTV-PyMT rather than the MMTV-Neu human breast cancer model. Otsuka Y, Oikawa T, Yoshino H, Hashimoto S, Handa H, Yamamoto H, Hashimoto A, Sabe H. Cell Commun Signal. 2018 Jan 5;16(1):1. doi: 10.1186/s12964-017-0212-z. PubMed |
| Foxo-dependent Par-4 Upregulation Prevents Long-term Survival of Residual Cells Following PI3K-Akt Inhibition. Damrauer JS, Phelps SN, Amuchastegui K, Lupo R, Mabe NW, Walens A, Kroger BR, Alvarez JV. Mol Cancer Res. 2018 Apr;16(4):599-609. doi: 10.1158/1541-7786.MCR-17-0492. Epub 2018 Jan 12. PubMed |
| High STAP1 expression in DUX4-rearranged cases is not suitable as therapeutic target in pediatric B-cell precursor acute lymphoblastic leukemia. Steeghs EMP, Bakker M, Hoogkamer AQ, Boer JM, Hartman QJ, Stalpers F, Escherich G, de Haas V, de Groot-Kruseman HA, Pieters R, den Boer ML. Sci Rep. 2018 Jan 12;8(1):693. doi: 10.1038/s41598-017-17704-4. PubMed |
Dual gene activation and knockout screen reveals directional dependencies in genetic networks.
Boettcher M, Tian R, Blau JA, Markegard E, Wagner RT, Wu D, Mo X, Biton A, Zaitlen N, Fu H, McCormick F, Kampmann M, McManus MT.
Nat Biotechnol. 2018 Jan 15. pii: nbt.4062. doi: 10.1038/nbt.4062.
PubMed
Associated Plasmids |
In vivo simultaneous transcriptional activation of multiple genes in the brain using CRISPR-dCas9-activator transgenic mice.
Zhou H, Liu J, Zhou C, Gao N, Rao Z, Li H, Hu X, Li C, Yao X, Shen X, Sun Y, Wei Y, Liu F, Ying W, Zhang J, Tang C, Zhang X, Xu H, Shi L, Cheng L, Huang P, Yang H.
Nat Neurosci. 2018 Jan 15. pii: 10.1038/s41593-017-0060-6. doi: 10.1038/s41593-017-0060-6.
PubMed
Associated Plasmids |
| Temporal Layering of Signaling Effectors Drives Chromatin Remodeling during Hair Follicle Stem Cell Lineage Progression. Adam RC, Yang H, Ge Y, Lien WH, Wang P, Zhao Y, Polak L, Levorse J, Baksh SC, Zheng D, Fuchs E. Cell Stem Cell. 2018 Mar 1;22(3):398-413.e7. doi: 10.1016/j.stem.2017.12.004. Epub 2018 Jan 11. PubMed |
| Human caspase-4 detects tetra-acylated LPS and cytosolic Francisella and functions differently from murine caspase-11. Lagrange B, Benaoudia S, Wallet P, Magnotti F, Provost A, Michal F, Martin A, Di Lorenzo F, Py BF, Molinaro A, Henry T. Nat Commun. 2018 Jan 16;9(1):242. doi: 10.1038/s41467-017-02682-y. PubMed |
| Human Herpesvirus 8 Interferon Regulatory Factors 1 and 3 Mediate Replication and Latency Activities via Interactions with USP7 Deubiquitinase. Xiang Q, Ju H, Li Q, Mei SC, Chen D, Choi YB, Nicholas J. J Virol. 2018 Mar 14;92(7). pii: JVI.02003-17. doi: 10.1128/JVI.02003-17. Print 2018 Apr 1. PubMed |
| The protective role of DOT1L in UV-induced melanomagenesis. Zhu B, Chen S, Wang H, Yin C, Han C, Peng C, Liu Z, Wan L, Zhang X, Zhang J, Lian CG, Ma P, Xu ZX, Prince S, Wang T, Gao X, Shi Y, Liu D, Liu M, Wei W, Wei Z, Pan J, Wang Y, Xuan Z, Hess J, Hayward NK, Goding CR, Chen X, Zhou J, Cui R. Nat Commun. 2018 Jan 17;9(1):259. doi: 10.1038/s41467-017-02687-7. PubMed |
| Loss of functional BAP1 augments sensitivity to TRAIL in cancer cells. Kolluri KK, Alifrangis C, Kumar N, Ishii Y, Price S, Michaut M, Williams S, Barthorpe S, Lightfoot H, Busacca S, Sharkey A, Yuan Z, Sage EK, Vallath S, Le Quesne J, Tice DA, Alrifai D, von Karstedt S, Montinaro A, Guppy N, Waller DA, Nakas A, Good R, Holmes A, Walczak H, Fennell DA, Garnett M, Iorio F, Wessels L, McDermott U, Janes SM. Elife. 2018 Jan 18;7. pii: 30224. doi: 10.7554/eLife.30224. PubMed |
| The RIG-I-like receptor LGP2 inhibits Dicer-dependent processing of long double-stranded RNA and blocks RNA interference in mammalian cells. van der Veen AG, Maillard PV, Schmidt JM, Lee SA, Deddouche-Grass S, Borg A, Kjaer S, Snijders AP, Reis E Sousa C. EMBO J. 2018 Feb 15;37(4). pii: embj.201797479. doi: 10.15252/embj.201797479. Epub 2018 Jan 19. PubMed |
| Unique properties of TCR-activated p38 are necessary for NFAT-dependent T-cell activation. Alam MS, Gaida MM, Debnath S, Tagad HD, Miller Jenkins LM, Appella E, Rahman MJ, Ashwell JD. PLoS Biol. 2018 Jan 22;16(1):e2004111. doi: 10.1371/journal.pbio.2004111. eCollection 2018 Jan. PubMed |
| Interferon regulatory factor 8 regulates caspase-1 expression to facilitate Epstein-Barr virus reactivation in response to B cell receptor stimulation and chemical induction. Lv DW, Zhang K, Li R. PLoS Pathog. 2018 Jan 22;14(1):e1006868. doi: 10.1371/journal.ppat.1006868. eCollection 2018 Jan. PubMed |
| CRISPR-Based Chromatin Remodeling of the Endogenous Oct4 or Sox2 Locus Enables Reprogramming to Pluripotency. Liu P, Chen M, Liu Y, Qi LS, Ding S. Cell Stem Cell. 2018 Feb 1;22(2):252-261.e4. doi: 10.1016/j.stem.2017.12.001. Epub 2018 Jan 18. PubMed |
| Nucleoplasmic lamins define growth-regulating functions of lamina-associated polypeptide 2alpha in progeria cells. Vidak S, Georgiou K, Fichtinger P, Naetar N, Dechat T, Foisner R. J Cell Sci. 2018 Feb 8;131(3). pii: jcs.208462. doi: 10.1242/jcs.208462. PubMed |
| HNRNPH1 is required for rhabdomyosarcoma cell growth and survival. Li Y, Bakke J, Finkelstein D, Zeng H, Wu J, Chen T. Oncogenesis. 2018 Jan 24;7(1):9. doi: 10.1038/s41389-017-0024-4. PubMed |
| Human Papillomavirus 16 E7 Stabilizes APOBEC3A Protein by Inhibiting Cullin 2-Dependent Protein Degradation. Westrich JA, Warren CJ, Klausner MJ, Guo K, Liu CW, Santiago ML, Pyeon D. J Virol. 2018 Mar 14;92(7). pii: JVI.01318-17. doi: 10.1128/JVI.01318-17. Print 2018 Apr 1. PubMed |
| Rab18 promotes lipid droplet (LD) growth by tethering the ER to LDs through SNARE and NRZ interactions. Xu D, Li Y, Wu L, Li Y, Zhao D, Yu J, Huang T, Ferguson C, Parton RG, Yang H, Li P. J Cell Biol. 2018 Mar 5;217(3):975-995. doi: 10.1083/jcb.201704184. Epub 2018 Jan 24. PubMed |
| Ex vivo Trophoblast-specific Genetic Manipulation Using Lentiviral Delivery. Chakraborty D, Muto M, Soares MJ. Bio Protoc. 2017 Dec 20;7(24):e2652. doi: 10.21769/BioProtoc.2652. PubMed |
| Necessity of p53-binding to the CDH1 locus for its expression defines two epithelial cell types differing in their integrity. Oikawa T, Otsuka Y, Onodera Y, Horikawa M, Handa H, Hashimoto S, Suzuki Y, Sabe H. Sci Rep. 2018 Jan 25;8(1):1595. doi: 10.1038/s41598-018-20043-7. PubMed |
| Third-Generation Human Epidermal Growth Factor Receptor 2 Chimeric Antigen Receptor Expression on Human T Cells Improves with Two-Signal Activation. Dalal AR, Homsy S, Balkhi MY. Hum Gene Ther. 2018 Aug;29(8):845-852. doi: 10.1089/hum.2017.244. Epub 2018 Mar 20. PubMed |
| ERAD-dependent control of the Wnt secretory factor Evi. Glaeser K, Urban M, Fenech E, Voloshanenko O, Kranz D, Lari F, Christianson JC, Boutros M. EMBO J. 2018 Feb 15;37(4). pii: embj.201797311. doi: 10.15252/embj.201797311. Epub 2018 Jan 29. PubMed |
| Estrogen receptor alpha protects pancreatic beta-cells from apoptosis by preserving mitochondrial function and suppressing endoplasmic reticulum stress. Zhou Z, Ribas V, Rajbhandari P, Drew BG, Moore TM, Fluitt AH, Reddish BR, Whitney KA, Georgia S, Vergnes L, Reue K, Liesa M, Shirihai O, van der Bliek AM, Chi NW, Mahata SK, Tiano JP, Hewitt SC, Tontonoz P, Korach KS, Mauvais-Jarvis F, Hevener AL. J Biol Chem. 2018 Mar 30;293(13):4735-4751. doi: 10.1074/jbc.M117.805069. Epub 2018 Jan 29. PubMed |
| Dynamic evolution of regulatory element ensembles in primate CD4(+) T cells. Danko CG, Choate LA, Marks BA, Rice EJ, Wang Z, Chu T, Martins AL, Dukler N, Coonrod SA, Tait Wojno ED, Lis JT, Kraus WL, Siepel A. Nat Ecol Evol. 2018 Mar;2(3):537-548. doi: 10.1038/s41559-017-0447-5. Epub 2018 Jan 29. PubMed |
| Enhancer invasion shapes MYCN-dependent transcriptional amplification in neuroblastoma. Zeid R, Lawlor MA, Poon E, Reyes JM, Fulciniti M, Lopez MA, Scott TG, Nabet B, Erb MA, Winter GE, Jacobson Z, Polaski DR, Karlin KL, Hirsch RA, Munshi NP, Westbrook TF, Chesler L, Lin CY, Bradner JE. Nat Genet. 2018 Apr;50(4):515-523. doi: 10.1038/s41588-018-0044-9. Epub 2018 Jan 29. PubMed |
| Human ex vivo prostate tissue model system identifies ING3 as an oncoprotein. McClurg UL, Nabbi A, Ricordel C, Korolchuk S, McCracken S, Heer R, Wilson L, Butler LM, Irving-Hooper BK, Pedeux R, Robson CN, Riabowol KT, Binda O. Br J Cancer. 2018 Mar 6;118(5):713-726. doi: 10.1038/bjc.2017.447. Epub 2018 Jan 30. PubMed |
| Phosphatidylinositol-(4, 5)-bisphosphate regulates calcium gating of small-conductance cation channel TMEM16F. Ye W, Han TW, Nassar LM, Zubia M, Jan YN, Jan LY. Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):E1667-E1674. doi: 10.1073/pnas.1718728115. Epub 2018 Jan 30. PubMed |
| CD209a Synergizes with Dectin-2 and Mincle to Drive Severe Th17 Cell-Mediated Schistosome Egg-Induced Immunopathology. Kalantari P, Morales Y, Miller EA, Jaramillo LD, Ponichtera HE, Wuethrich MA, Cheong C, Seminario MC, Russo JM, Bunnell SC, Stadecker MJ. Cell Rep. 2018 Jan 30;22(5):1288-1300. doi: 10.1016/j.celrep.2018.01.001. PubMed |
| ATP12A promotes mucus dysfunction during Type 2 airway inflammation. Lennox AT, Coburn SL, Leech JA, Heidrich EM, Kleyman TR, Wenzel SE, Pilewski JM, Corcoran TE, Myerburg MM. Sci Rep. 2018 Feb 1;8(1):2109. doi: 10.1038/s41598-018-20444-8. PubMed |
| The Application of Non-Invasive Apoptosis Detection Sensor (NIADS) on Histone Deacetylation Inhibitor (HDACi)-Induced Breast Cancer Cell Death. Hsu KW, Huang CY, Tam KW, Lin CY, Huang LC, Lin CL, Hsieh WS, Chi WM, Chang YJ, Wei PL, Chen ST, Lee CH. Int J Mol Sci. 2018 Feb 2;19(2). pii: ijms19020452. doi: 10.3390/ijms19020452. PubMed |
| Inhibition of Dpp8/9 Activates the Nlrp1b Inflammasome. Okondo MC, Rao SD, Taabazuing CY, Chui AJ, Poplawski SE, Johnson DC, Bachovchin DA. Cell Chem Biol. 2018 Mar 15;25(3):262-267.e5. doi: 10.1016/j.chembiol.2017.12.013. Epub 2018 Jan 27. PubMed |
| Tuning microtubule dynamics to enhance cancer therapy by modulating FER-mediated CRMP2 phosphorylation. Zheng Y, Sethi R, Mangala LS, Taylor C, Goldsmith J, Wang M, Masuda K, Karaminejadranjbar M, Mannion D, Miranda F, Herrero-Gonzalez S, Hellner K, Chen F, Alsaadi A, Albukhari A, Fotso DC, Yau C, Jiang D, Pradeep S, Rodriguez-Aguayo C, Lopez-Berestein G, Knapp S, Gray NS, Campo L, Myers KA, Dhar S, Ferguson D, Bast RC Jr, Sood AK, von Delft F, Ahmed AA. Nat Commun. 2018 Feb 2;9(1):476. doi: 10.1038/s41467-017-02811-7. PubMed |
| Losmapimod Overcomes Gefitinib Resistance in Non-small Cell Lung Cancer by Preventing Tetraploidization. Yeung YT, Yin S, Lu B, Fan S, Yang R, Bai R, Zhang C, Bode AM, Liu K, Dong Z. EBioMedicine. 2018 Feb;28:51-61. doi: 10.1016/j.ebiom.2018.01.017. Epub 2018 Feb 2. PubMed |
| Antiviral and anti-inflammatory activity of budesonide against human rhinovirus infection mediated via autophagy activation. Kim SR, Song JH, Ahn JH, Lee GS, Ahn H, Yoon SI, Kang SG, Kim PH, Jeon SM, Choi EJ, Shin S, Cha Y, Cho S, Kim DE, Chang SY, Ko HJ. Antiviral Res. 2018 Mar;151:87-96. doi: 10.1016/j.antiviral.2018.01.012. Epub 2018 Feb 3. PubMed |
| MAX to MYCN intracellular ratio drives the aggressive phenotype and clinical outcome of high risk neuroblastoma. Ferrucci F, Ciaccio R, Monticelli S, Pigini P, di Giacomo S, Purgato S, Erriquez D, Bernardoni R, Norris M, Haber M, Milazzo G, Perini G. Biochim Biophys Acta Gene Regul Mech. 2018 Mar;1861(3):235-245. doi: 10.1016/j.bbagrm.2018.01.007. Epub 2018 Feb 3. PubMed |
| Therapeutic Potential of Lentivirus-Mediated Glucagon-Like Peptide-1 Gene Therapy for Diabetes. Tasyurek HM, Altunbas HA, Balci MK, Griffith TS, Sanlioglu S. Hum Gene Ther. 2018 Jul;29(7):802-815. doi: 10.1089/hum.2017.180. Epub 2018 Mar 20. PubMed |
| Translational control of ERK signaling through miRNA/4EHP-directed silencing. Jafarnejad SM, Chapat C, Matta-Camacho E, Gelbart IA, Hesketh GG, Arguello M, Garzia A, Kim SH, Attig J, Shapiro M, Morita M, Khoutorsky A, Alain T, Gkogkas CG, Stern-Ginossar N, Tuschl T, Gingras AC, Duchaine TF, Sonenberg N. Elife. 2018 Feb 7;7. pii: 35034. doi: 10.7554/eLife.35034. PubMed |
| Lrp6 is a target of the PTH-activated alphaNAC transcriptional coregulator. Pellicelli M, Hariri H, Miller JA, St-Arnaud R. Biochim Biophys Acta Gene Regul Mech. 2018 Feb;1861(2):61-71. doi: 10.1016/j.bbagrm.2018.01.008. Epub 2018 Feb 3. PubMed |
| Picornavirus 2A protease regulates stress granule formation to facilitate viral translation. Yang X, Hu Z, Fan S, Zhang Q, Zhong Y, Guo D, Qin Y, Chen M. PLoS Pathog. 2018 Feb 7;14(2):e1006901. doi: 10.1371/journal.ppat.1006901. eCollection 2018 Feb. PubMed |
| The Role of Trio, a Rho Guanine Nucleotide Exchange Factor, in Glomerular Podocytes. Maier M, Baldwin C, Aoudjit L, Takano T. Int J Mol Sci. 2018 Feb 6;19(2). pii: ijms19020479. doi: 10.3390/ijms19020479. PubMed |
| Deguelin suppresses angiogenesis in human hepatocellular carcinoma by targeting HGF-c-Met pathway. Li M, Yu X, Li W, Liu T, Deng G, Liu W, Liu H, Gao F. Oncotarget. 2017 Oct 26;9(1):152-166. doi: 10.18632/oncotarget.22077. eCollection 2018 Jan 2. PubMed |
The TIA1 RNA-Binding Protein Family Regulates EIF2AK2-Mediated Stress Response and Cell Cycle Progression.
Meyer C, Garzia A, Mazzola M, Gerstberger S, Molina H, Tuschl T.
Mol Cell. 2018 Feb 15;69(4):622-635.e6. doi: 10.1016/j.molcel.2018.01.011.
PubMed
Associated Plasmids |
| Intratumoral Delivery of Interferongamma-Secreting Mesenchymal Stromal Cells Repolarizes Tumor-Associated Macrophages and Suppresses Neuroblastoma Proliferation In Vivo. Relation T, Yi T, Guess AJ, La Perle K, Otsuru S, Hasgur S, Dominici M, Breuer C, Horwitz EM. Stem Cells. 2018 Jun;36(6):915-924. doi: 10.1002/stem.2801. Epub 2018 Feb 27. PubMed |
| microRNA-193a stimulates pancreatic cancer cell repopulation and metastasis through modulating TGF-beta2/TGF-betaRIII signalings. Fang C, Dai CY, Mei Z, Jiang MJ, Gu DN, Huang Q, Tian L. J Exp Clin Cancer Res. 2018 Feb 13;37(1):25. doi: 10.1186/s13046-018-0697-3. PubMed |
| SLAMF1 is required for TLR4-mediated TRAM-TRIF-dependent signaling in human macrophages. Yurchenko M, Skjesol A, Ryan L, Richard GM, Kandasamy RK, Wang N, Terhorst C, Husebye H, Espevik T. J Cell Biol. 2018 Apr 2;217(4):1411-1429. doi: 10.1083/jcb.201707027. Epub 2018 Feb 12. PubMed |
| Differential role of FL-BID and t-BID during verotoxin-1-induced apoptosis in Burkitt's lymphoma cells. Debernardi J, Hollville E, Lipinski M, Wiels J, Robert A. Oncogene. 2018 May;37(18):2410-2421. doi: 10.1038/s41388-018-0123-5. Epub 2018 Feb 14. PubMed |
| En masse lentiviral gene delivery to mouse fertilized eggs via laser perforation of zona pellucida. Martin NP, Myers P, Goulding E, Chen SH, Walker M, Porter TM, Van Gorder L, Mathew A, Gruzdev A, Romeo C. Transgenic Res. 2018 Feb;27(1):39-49. doi: 10.1007/s11248-017-0056-8. Epub 2018 Feb 13. PubMed |
| A novel in vitro model for the assessment of postnatal myonuclear accretion. Kneppers A, Verdijk L, de Theije C, Corten M, Gielen E, van Loon L, Schols A, Langen R. Skelet Muscle. 2018 Feb 14;8(1):4. doi: 10.1186/s13395-018-0151-4. PubMed |
| Dynamic network biomarker indicates pulmonary metastasis at the tipping point of hepatocellular carcinoma. Yang B, Li M, Tang W, Liu W, Zhang S, Chen L, Xia J. Nat Commun. 2018 Feb 14;9(1):678. doi: 10.1038/s41467-018-03024-2. PubMed |
| A paralogous pair of mammalian host restriction factors form a critical host barrier against poxvirus infection. Meng X, Zhang F, Yan B, Si C, Honda H, Nagamachi A, Sun LZ, Xiang Y. PLoS Pathog. 2018 Feb 15;14(2):e1006884. doi: 10.1371/journal.ppat.1006884. eCollection 2018 Feb. PubMed |
| HuR-mediated SCN5A messenger RNA stability reduces arrhythmic risk in heart failure. Zhou A, Xie A, Kim TY, Liu H, Shi G, Kang GJ, Jiang N, Liu M, Jeong EM, Choi BR, Dudley SC Jr. Heart Rhythm. 2018 Jul;15(7):1072-1080. doi: 10.1016/j.hrthm.2018.02.018. Epub 2018 Feb 16. PubMed |
| Chronic hyperinsulinemia induced miR-27b is linked to adipocyte insulin resistance by targeting insulin receptor. Srivastava A, Shankar K, Beg M, Rajan S, Gupta A, Varshney S, Kumar D, Gupta S, Mishra RK, Gaikwad AN. J Mol Med (Berl). 2018 Apr;96(3-4):315-331. doi: 10.1007/s00109-018-1623-z. Epub 2018 Feb 17. PubMed |
| The contribution of SP100 to cottontail rabbit papillomavirus transcription and replication. Wurdak M, Schneider M, Iftner T, Stubenrauch F. J Gen Virol. 2018 Jan 24. doi: 10.1099/jgv.0.001012. PubMed |
| A negative feedback regulation of MTORC1 activity by the lysosomal Ca(2+) channel MCOLN1 (mucolipin 1) using a CALM (calmodulin)-dependent mechanism. Sun X, Yang Y, Zhong XZ, Cao Q, Zhu XH, Zhu X, Dong XP. Autophagy. 2018;14(1):38-52. doi: 10.1080/15548627.2017.1389822. Epub 2018 Feb 20. PubMed |
| Human AK2 links intracellular bioenergetic redistribution to the fate of hematopoietic progenitors. Oshima K, Saiki N, Tanaka M, Imamura H, Niwa A, Tanimura A, Nagahashi A, Hirayama A, Okita K, Hotta A, Kitayama S, Osawa M, Kaneko S, Watanabe A, Asaka I, Fujibuchi W, Imai K, Yabe H, Kamachi Y, Hara J, Kojima S, Tomita M, Soga T, Noma T, Nonoyama S, Nakahata T, Saito MK. Biochem Biophys Res Commun. 2018 Mar 4;497(2):719-725. doi: 10.1016/j.bbrc.2018.02.139. Epub 2018 Feb 17. PubMed |
| Clonal dynamics towards the development of venetoclax resistance in chronic lymphocytic leukemia. Herling CD, Abedpour N, Weiss J, Schmitt A, Jachimowicz RD, Merkel O, Cartolano M, Oberbeck S, Mayer P, Berg V, Thomalla D, Kutsch N, Stiefelhagen M, Cramer P, Wendtner CM, Persigehl T, Saleh A, Altmuller J, Nurnberg P, Pallasch C, Achter V, Lang U, Eichhorst B, Castiglione R, Schafer SC, Buttner R, Kreuzer KA, Reinhardt HC, Hallek M, Frenzel LP, Peifer M. Nat Commun. 2018 Feb 20;9(1):727. doi: 10.1038/s41467-018-03170-7. PubMed |
| sAPPbeta and sAPPalpha increase structural complexity and E/I input ratio in primary hippocampal neurons and alter Ca(2+) homeostasis and CREB1-signaling. Hesse R, von Einem B, Wagner F, Bott P, Schwanzar D, Jackson RJ, Fohr KJ, Lausser L, Kroker KS, Proepper C, Walther P, Kestler HA, Spires-Jones TL, Boeckers T, Rosenbrock H, von Arnim CAF. Exp Neurol. 2018 Jun;304:1-13. doi: 10.1016/j.expneurol.2018.02.010. Epub 2018 Feb 18. PubMed |
| Membrane detachment is not essential for COG complex function. Climer LK, Pokrovskaya ID, Blackburn JB, Lupashin VV. Mol Biol Cell. 2018 Apr 15;29(8):964-974. doi: 10.1091/mbc.E17-11-0694. Epub 2018 Mar 30. PubMed |
| Dissecting the Causal Mechanism of X-Linked Dystonia-Parkinsonism by Integrating Genome and Transcriptome Assembly. Aneichyk T, Hendriks WT, Yadav R, Shin D, Gao D, Vaine CA, Collins RL, Domingo A, Currall B, Stortchevoi A, Multhaupt-Buell T, Penney EB, Cruz L, Dhakal J, Brand H, Hanscom C, Antolik C, Dy M, Ragavendran A, Underwood J, Cantsilieris S, Munson KM, Eichler EE, Acuna P, Go C, Jamora RDG, Rosales RL, Church DM, Williams SR, Garcia S, Klein C, Muller U, Wilhelmsen KC, Timmers HTM, Sapir Y, Wainger BJ, Henderson D, Ito N, Weisenfeld N, Jaffe D, Sharma N, Breakefield XO, Ozelius LJ, Bragg DC, Talkowski ME. Cell. 2018 Feb 22;172(5):897-909.e21. doi: 10.1016/j.cell.2018.02.011. PubMed |
| Knockdown of Human AMPK Using the CRISPR/Cas9 Genome-Editing System. Grenier A, Sujobert P, Olivier S, Guermouche H, Mondesir J, Kosmider O, Viollet B, Tamburini J. Methods Mol Biol. 2018;1732:171-194. doi: 10.1007/978-1-4939-7598-3_11. PubMed |
| SMARCB1 Deficiency Integrates Epigenetic Signals to Oncogenic Gene Expression Program Maintenance in Human Acute Myeloid Leukemia. Chatterjee SS, Biswas M, Boila LD, Banerjee D, Sengupta A. Mol Cancer Res. 2018 May;16(5):791-804. doi: 10.1158/1541-7786.MCR-17-0493. Epub 2018 Feb 26. PubMed |
| The Histone Variant MacroH2A Blocks Cellular Reprogramming by Inhibiting Mesenchymal-to-Epithelial Transition. Pliatska M, Kapasa M, Kokkalis A, Polyzos A, Thanos D. Mol Cell Biol. 2018 Apr 30;38(10). pii: MCB.00669-17. doi: 10.1128/MCB.00669-17. Print 2018 May 15. PubMed |
| Fatty Acid Synthase induced S6Kinase facilitates USP11-eIF4B complex formation for sustained oncogenic translation in DLBCL. Kapadia B, Nanaji NM, Bhalla K, Bhandary B, Lapidus R, Beheshti A, Evens AM, Gartenhaus RB. Nat Commun. 2018 Feb 26;9(1):829. doi: 10.1038/s41467-018-03028-y. PubMed |
| Screening, large-scale production and structure-based classification of cystine-dense peptides. Correnti CE, Gewe MM, Mehlin C, Bandaranayake AD, Johnsen WA, Rupert PB, Brusniak MY, Clarke M, Burke SE, De Van Der Schueren W, Pilat K, Turnbaugh SM, May D, Watson A, Chan MK, Bahl CD, Olson JM, Strong RK. Nat Struct Mol Biol. 2018 Mar;25(3):270-278. doi: 10.1038/s41594-018-0033-9. Epub 2018 Feb 26. PubMed |
| Identification of interactions among host and bacterial proteins and evaluation of their role early during Shigella flexneri infection. Miller KA, Garza-Mayers AC, Leung Y, Goldberg MB. Microbiology. 2018 Apr;164(4):540-550. doi: 10.1099/mic.0.000637. Epub 2018 Feb 28. PubMed |
| Engineering Axl specific CAR and SynNotch receptor for cancer therapy. Cho JH, Okuma A, Al-Rubaye D, Intisar E, Junghans RP, Wong WW. Sci Rep. 2018 Mar 1;8(1):3846. doi: 10.1038/s41598-018-22252-6. PubMed |
| ERK1/2 activated PHLPP1 induces skeletal muscle ER stress through the inhibition of a novel substrate AMPK. Behera S, Kapadia B, Kain V, Alamuru-Yellapragada NP, Murunikkara V, Kumar ST, Babu PP, Seshadri S, Shivarudraiah P, Hiriyan J, Gangula NR, Maddika S, Misra P, Parsa KVL. Biochim Biophys Acta Mol Basis Dis. 2018 May;1864(5 Pt A):1702-1716. doi: 10.1016/j.bbadis.2018.02.019. Epub 2018 Feb 27. PubMed |
| High Efficiency Gene Correction in Hematopoietic Cells by Donor-Template-Free CRISPR/Cas9 Genome Editing. Surun D, Schwable J, Tomasovic A, Ehling R, Stein S, Kurrle N, von Melchner H, Schnutgen F. Mol Ther Nucleic Acids. 2018 Mar 2;10:1-8. doi: 10.1016/j.omtn.2017.11.001. Epub 2017 Nov 10. PubMed |
| Enhanced insulin receptor, but not PI3K, signalling protects podocytes from ER stress. Garner KL, Betin VMS, Pinto V, Graham M, Abgueguen E, Barnes M, Bedford DC, McArdle CA, Coward RJM. Sci Rep. 2018 Mar 2;8(1):3902. doi: 10.1038/s41598-018-22233-9. PubMed |
| Novel RNA-Affinity Proteogenomics Dissects Tumor Heterogeneity for Revealing Personalized Markers in Precision Prognosis of Cancer. Wang L, Wrobel JA, Xie L, Li D, Zurlo G, Shen H, Yang P, Wang Z, Peng Y, Gunawardena HP, Zhang Q, Chen X. Cell Chem Biol. 2018 May 17;25(5):619-633.e5. doi: 10.1016/j.chembiol.2018.01.016. Epub 2018 Mar 1. PubMed |
| Functional TRIM24 degrader via conjugation of ineffectual bromodomain and VHL ligands. Gechijian LN, Buckley DL, Lawlor MA, Reyes JM, Paulk J, Ott CJ, Winter GE, Erb MA, Scott TG, Xu M, Seo HS, Dhe-Paganon S, Kwiatkowski NP, Perry JA, Qi J, Gray NS, Bradner JE. Nat Chem Biol. 2018 Apr;14(4):405-412. doi: 10.1038/s41589-018-0010-y. Epub 2018 Mar 5. PubMed |
| FLT3-ITD induces expression of Pim kinases through STAT5 to confer resistance to the PI3K/Akt pathway inhibitors on leukemic cells by enhancing the mTORC1/Mcl-1 pathway. Okada K, Nogami A, Ishida S, Akiyama H, Chen C, Umezawa Y, Miura O. Oncotarget. 2017 Dec 4;9(10):8870-8886. doi: 10.18632/oncotarget.22926. eCollection 2018 Feb 6. PubMed |
| Site-specific glycosylation regulates the form and function of the intermediate filament cytoskeleton. Tarbet HJ, Dolat L, Smith TJ, Condon BM, O'Brien ET 3rd, Valdivia RH, Boyce M. Elife. 2018 Mar 7;7. pii: 31807. doi: 10.7554/eLife.31807. PubMed |
| Porcine MKRN1 Modulates the Replication and Pathogenesis of Porcine Circovirus Type 2 by Inducing Capsid Protein Ubiquitination and Degradation. Wang T, Du Q, Wu X, Niu Y, Guan L, Wang Z, Zhao X, Liu SL, Tong D, Huang Y. J Virol. 2018 May 14;92(11). pii: JVI.00100-18. doi: 10.1128/JVI.00100-18. Print 2018 Jun 1. PubMed |
| Tau Phosphorylation is Impacted by Rare AKAP9 Mutations Associated with Alzheimer Disease in African Americans. Ikezu T, Chen C, DeLeo AM, Zeldich E, Fallin MD, Kanaan NM, Lunetta KL, Abraham CR, Logue MW, Farrer LA. J Neuroimmune Pharmacol. 2018 Jun;13(2):254-264. doi: 10.1007/s11481-018-9781-x. Epub 2018 Mar 7. PubMed |
| The oxidized phospholipid oxPAPC protects from septic shock by targeting the non-canonical inflammasome in macrophages. Chu LH, Indramohan M, Ratsimandresy RA, Gangopadhyay A, Morris EP, Monack DM, Dorfleutner A, Stehlik C. Nat Commun. 2018 Mar 8;9(1):996. doi: 10.1038/s41467-018-03409-3. PubMed |
| Overexpression of the base excision repair NTHL1 glycosylase causes genomic instability and early cellular hallmarks of cancer. Limpose KL, Trego KS, Li Z, Leung SW, Sarker AH, Shah JA, Ramalingam SS, Werner EM, Dynan WS, Cooper PK, Corbett AH, Doetsch PW. Nucleic Acids Res. 2018 May 18;46(9):4515-4532. doi: 10.1093/nar/gky162. PubMed |
| A type III complement factor D deficiency: Structural insights for inhibition of the alternative pathway. Sng CCT, O'Byrne S, Prigozhin DM, Bauer MR, Harvey JC, Ruhle M, Challis BG, Lear S, Roberts LD, Workman S, Janowitz T, Magiera L, Doffinger R, Buckland MS, Jodrell DJ, Semple RK, Wilson TJ, Modis Y, Thaventhiran JED. J Allergy Clin Immunol. 2018 Jul;142(1):311-314.e6. doi: 10.1016/j.jaci.2018.01.048. Epub 2018 Mar 6. PubMed |
Establishment of Cell Lines Stably Expressing dCas9-Fusions to Address Kinetics of Epigenetic Editing.
Goubert D, Koncz M, Kiss A, Rots MG.
Methods Mol Biol. 2018;1767:395-415. doi: 10.1007/978-1-4939-7774-1_22.
PubMed
Associated Plasmids |
| Screening Regulatory Element Function with CRISPR/Cas9-based Epigenome Editing. Klann TS, Crawford GE, Reddy TE, Gersbach CA. Methods Mol Biol. 2018;1767:447-480. doi: 10.1007/978-1-4939-7774-1_25. PubMed |
| Human IFIT3 Modulates IFIT1 RNA Binding Specificity and Protein Stability. Johnson B, VanBlargan LA, Xu W, White JP, Shan C, Shi PY, Zhang R, Adhikari J, Gross ML, Leung DW, Diamond MS, Amarasinghe GK. Immunity. 2018 Mar 20;48(3):487-499.e5. doi: 10.1016/j.immuni.2018.01.014. Epub 2018 Mar 8. PubMed |
NuRD and CAF-1-mediated silencing of the D4Z4 array is modulated by DUX4-induced MBD3L proteins.
Campbell AE, Shadle SC, Jagannathan S, Lim JW, Resnick R, Tawil R, van der Maarel SM, Tapscott SJ.
Elife. 2018 Mar 13;7. pii: 31023. doi: 10.7554/eLife.31023.
PubMed
Associated Plasmids |
| PKM1 Confers Metabolic Advantages and Promotes Cell-Autonomous Tumor Cell Growth. Morita M, Sato T, Nomura M, Sakamoto Y, Inoue Y, Tanaka R, Ito S, Kurosawa K, Yamaguchi K, Sugiura Y, Takizaki H, Yamashita Y, Katakura R, Sato I, Kawai M, Okada Y, Watanabe H, Kondoh G, Matsumoto S, Kishimoto A, Obata M, Matsumoto M, Fukuhara T, Motohashi H, Suematsu M, Komatsu M, Nakayama KI, Watanabe T, Soga T, Shima H, Maemondo M, Tanuma N. Cancer Cell. 2018 Mar 12;33(3):355-367.e7. doi: 10.1016/j.ccell.2018.02.004. PubMed |
| GATA3 zinc finger 2 mutations reprogram the breast cancer transcriptional network. Takaku M, Grimm SA, Roberts JD, Chrysovergis K, Bennett BD, Myers P, Perera L, Tucker CJ, Perou CM, Wade PA. Nat Commun. 2018 Mar 13;9(1):1059. doi: 10.1038/s41467-018-03478-4. PubMed |
| Exacerbated Apoptosis of Cells Infected with Infectious Bursal Disease Virus upon Exposure to Interferon Alpha. Cubas-Gaona LL, Diaz-Beneitez E, Ciscar M, Rodriguez JF, Rodriguez D. J Virol. 2018 May 14;92(11). pii: JVI.00364-18. doi: 10.1128/JVI.00364-18. Print 2018 Jun 1. PubMed |
| MicroRNA-181c promotes Th17 cell differentiation and mediates experimental autoimmune encephalomyelitis. Zhang Z, Xue Z, Liu Y, Liu H, Guo X, Li Y, Yang H, Zhang L, Da Y, Yao Z, Zhang R. Brain Behav Immun. 2018 May;70:305-314. doi: 10.1016/j.bbi.2018.03.011. Epub 2018 Mar 12. PubMed |
| Lentiviral Transduction of Rat Schwann Cells and Dorsal Root Ganglia Neurons for In Vitro Myelination Studies. Heffernan C, Maurel P. Methods Mol Biol. 2018;1739:177-193. doi: 10.1007/978-1-4939-7649-2_12. PubMed |
| DNA Conformation Induces Adaptable Binding by Tandem Zinc Finger Proteins. Patel A, Yang P, Tinkham M, Pradhan M, Sun MA, Wang Y, Hoang D, Wolf G, Horton JR, Zhang X, Macfarlan T, Cheng X. Cell. 2018 Mar 22;173(1):221-233.e12. doi: 10.1016/j.cell.2018.02.058. Epub 2018 Mar 15. PubMed |
Transcriptome Engineering with RNA-Targeting Type VI-D CRISPR Effectors.
Konermann S, Lotfy P, Brideau NJ, Oki J, Shokhirev MN, Hsu PD.
Cell. 2018 Mar 8. pii: S0092-8674(18)30207-1. doi: 10.1016/j.cell.2018.02.033.
PubMed
Associated Plasmids |
Coordinated Activity of Y Family TLS Polymerases and EXO1 Protects Non-S Phase Cells from UV-Induced Cytotoxic Lesions.
Sertic S, Mollica A, Campus I, Roma S, Tumini E, Aguilera A, Muzi-Falconi M.
Mol Cell. 2018 Apr 5;70(1):34-47.e4. doi: 10.1016/j.molcel.2018.02.017. Epub 2018 Mar 15.
PubMed
Associated Plasmids |
| High Throughput NPY-Venus and Serotonin Secretion Assays for Regulated Exocytosis in Neuroendocrine Cells. Zhang XA, Martin TFJ. Bio Protoc. 2018 Jan 5;8(1). doi: 10.21769/BioProtoc.2680. PubMed |
| Pooled shRNA Screen for Reactivation of MeCP2 on the Inactive X Chromosome. Leko V, Sripathy S, Adrianse RL, Loe T, Park A, Lao U, Foss EJ, Bartolomei MS, Bedalov A. J Vis Exp. 2018 Mar 2;(133). doi: 10.3791/56398. PubMed |
A CRISPR screen for factors regulating SAMHD1 degradation identifies IFITMs as potent inhibitors of lentiviral particle delivery.
Roesch F, OhAinle M, Emerman M.
Retrovirology. 2018 Mar 20;15(1):26. doi: 10.1186/s12977-018-0409-2.
PubMed
Associated Plasmids |
| Overexpression of DNMT1 leads to hypermethylation of H19 promoter and inhibition of Erk signaling pathway in disuse osteoporosis. Li B, Zhao J, Ma JX, Li GM, Zhang Y, Xing GS, Liu J, Ma XL. Bone. 2018 Jun;111:82-91. doi: 10.1016/j.bone.2018.03.017. Epub 2018 Mar 16. PubMed |
| p23 protects the human aryl hydrocarbon receptor from degradation via a heat shock protein 90-independent mechanism. Pappas B, Yang Y, Wang Y, Kim K, Chung HJ, Cheung M, Ngo K, Shinn A, Chan WK. Biochem Pharmacol. 2018 Jun;152:34-44. doi: 10.1016/j.bcp.2018.03.015. Epub 2018 Mar 17. PubMed |
| Expression of Carbonic Anhydrase III, a Nucleus Pulposus Phenotypic Marker, is Hypoxia-responsive and Confers Protection from Oxidative Stress-induced Cell Death. Silagi ES, Batista P, Shapiro IM, Risbud MV. Sci Rep. 2018 Mar 20;8(1):4856. doi: 10.1038/s41598-018-23196-7. PubMed |
| H5N1 Influenza A Virus PB1-F2 Relieves HAX-1-Mediated Restriction of Avian Virus Polymerase PA in Human Lung Cells. Mazel-Sanchez B, Boal-Carvalho I, Silva F, Dijkman R, Schmolke M. J Virol. 2018 May 14;92(11). pii: JVI.00425-18. doi: 10.1128/JVI.00425-18. Print 2018 Jun 1. PubMed |
| A RAS-CaMKKbeta-AMPKalpha2 pathway promotes senescence by licensing post-translational activation of C/EBPbeta through a novel 3'UTR mechanism. Basu SK, Gonit M, Salotti J, Chen J, Bhat A, Gorospe M, Viollet B, Claffey KP, Johnson PF. Oncogene. 2018 Jun;37(26):3528-3548. doi: 10.1038/s41388-018-0190-7. Epub 2018 Mar 22. PubMed |
| GATA1s exerts developmental stage-specific effects in human hematopoiesis. Gialesaki S, Mahnken AK, Schmid L, Labuhn M, Bhayadia R, Heckl D, Klusmann JH. Haematologica. 2018 Aug;103(8):e336-e340. doi: 10.3324/haematol.2018.191338. Epub 2018 Mar 22. PubMed |
| miR-128 inhibits telomerase activity by targeting TERT mRNA. Guzman H, Sanders K, Idica A, Bochnakian A, Jury D, Daugaard I, Zisoulis DG, Pedersen IM. Oncotarget. 2018 Jan 19;9(17):13244-13253. doi: 10.18632/oncotarget.24284. eCollection 2018 Mar 2. PubMed |
| Impairment of an Endothelial NAD(+)-H2S Signaling Network Is a Reversible Cause of Vascular Aging. Das A, Huang GX, Bonkowski MS, Longchamp A, Li C, Schultz MB, Kim LJ, Osborne B, Joshi S, Lu Y, Trevino-Villarreal JH, Kang MJ, Hung TT, Lee B, Williams EO, Igarashi M, Mitchell JR, Wu LE, Turner N, Arany Z, Guarente L, Sinclair DA. Cell. 2018 Mar 22;173(1):74-89.e20. doi: 10.1016/j.cell.2018.02.008. PubMed |
Expression of a Constitutively Active Human Insulin Receptor in Hippocampal Neurons Does Not Alter VGCC Currents.
Frazier HN, Anderson KL, Maimaiti S, Ghoweri AO, Kraner SD, Popa GJ, Hampton KK, Mendenhall MD, Norris CM, Craven RJ, Thibault O.
Neurochem Res. 2019 Jan;44(1):269-280. doi: 10.1007/s11064-018-2510-2. Epub 2018 Mar 23.
PubMed
Associated Plasmids |
| Profound Tissue Specificity in Proliferation Control Underlies Cancer Drivers and Aneuploidy Patterns. Sack LM, Davoli T, Li MZ, Li Y, Xu Q, Naxerova K, Wooten EC, Bernardi RJ, Martin TD, Chen T, Leng Y, Liang AC, Scorsone KA, Westbrook TF, Wong KK, Elledge SJ. Cell. 2018 Apr 5;173(2):499-514.e23. doi: 10.1016/j.cell.2018.02.037. Epub 2018 Mar 22. PubMed |
| Remote Control of Mammalian Cells with Heat-Triggered Gene Switches and Photothermal Pulse Trains. Miller IC, Gamboa Castro M, Maenza J, Weis JP, Kwong GA. ACS Synth Biol. 2018 Apr 20;7(4):1167-1173. doi: 10.1021/acssynbio.7b00455. Epub 2018 Apr 10. PubMed |
| Molecular cloning, expression, and characterization of UDP N-acetyl-alpha-d-galactosamine: Polypeptide N-acetylgalactosaminyltransferase 4 from Cryptosporidium parvum. DeCicco RePass MA, Bhat N, Heimburg-Molinaro J, Bunnell S, Cummings RD, Ward HD. Mol Biochem Parasitol. 2018 Apr;221:56-65. doi: 10.1016/j.molbiopara.2018.03.002. Epub 2018 Mar 23. PubMed |
| LentiPro26: novel stable cell lines for constitutive lentiviral vector production. Tomas HA, Rodrigues AF, Carrondo MJT, Coroadinha AS. Sci Rep. 2018 Mar 27;8(1):5271. doi: 10.1038/s41598-018-23593-y. PubMed |
| Knockdown of HuR represses osteosarcoma cells migration, invasion and stemness through inhibition of YAP activation and increases susceptibility to chemotherapeutic agents. Xu W, Chen C, Xu R, Li Y, Hu R, Li Z, Zhu X. Biomed Pharmacother. 2018 Jun;102:587-593. doi: 10.1016/j.biopha.2018.03.098. Epub 2018 Apr 5. PubMed |
| ER-positive breast cancer cells are poised for RET-mediated endocrine resistance. Horibata S, Rice EJ, Mukai C, Marks BA, Sams K, Zheng H, Anguish LJ, Coonrod SA, Danko CG. PLoS One. 2018 Apr 2;13(4):e0194023. doi: 10.1371/journal.pone.0194023. eCollection 2018. PubMed |
| Real-Time Imaging of Dynamic Cell Reprogramming with Nanosensors. Wiraja C, Yeo DC, Tham KC, Chew SWT, Lim X, Xu C. Small. 2018 Apr;14(17):e1703440. doi: 10.1002/smll.201703440. Epub 2018 Apr 3. PubMed |
| Induction, regulation and roles of neural adhesion molecule L1CAM in cellular senescence. Mrazkova B, Dzijak R, Imrichova T, Kyjacova L, Barath P, Dzubak P, Holub D, Hajduch M, Nahacka Z, Andera L, Holicek P, Vasicova P, Sapega O, Bartek J, Hodny Z. Aging (Albany NY). 2018 Mar 28;10(3):434-462. doi: 10.18632/aging.101404. PubMed |
| Genetic abrogation of immune checkpoints in antigen-specific cytotoxic T-lymphocyte as a potential alternative to blockade immunotherapy. Zhang C, Peng Y, Hublitz P, Zhang H, Dong T. Sci Rep. 2018 Apr 3;8(1):5549. doi: 10.1038/s41598-018-23803-7. PubMed |
| Metabolic enzyme PFKFB4 activates transcriptional coactivator SRC-3 to drive breast cancer. Dasgupta S, Rajapakshe K, Zhu B, Nikolai BC, Yi P, Putluri N, Choi JM, Jung SY, Coarfa C, Westbrook TF, Zhang XH, Foulds CE, Tsai SY, Tsai MJ, O'Malley BW. Nature. 2018 Apr;556(7700):249-254. doi: 10.1038/s41586-018-0018-1. Epub 2018 Apr 3. PubMed |
| Molecular Characterization and Clinical Relevance of Metabolic Expression Subtypes in Human Cancers. Peng X, Chen Z, Farshidfar F, Xu X, Lorenzi PL, Wang Y, Cheng F, Tan L, Mojumdar K, Du D, Ge Z, Li J, Thomas GV, Birsoy K, Liu L, Zhang H, Zhao Z, Marchand C, Weinstein JN, Bathe OF, Liang H. Cell Rep. 2018 Apr 3;23(1):255-269.e4. doi: 10.1016/j.celrep.2018.03.077. PubMed |
| Autophagy regulates testosterone synthesis by facilitating cholesterol uptake in Leydig cells. Gao F, Li G, Liu C, Gao H, Wang H, Liu W, Chen M, Shang Y, Wang L, Shi J, Xia W, Jiao J, Gao F, Li J, Chen L, Li W. J Cell Biol. 2018 Jun 4;217(6):2103-2119. doi: 10.1083/jcb.201710078. Epub 2018 Apr 4. PubMed |
| Decreased expression of SFRP2 promotes development of the pituitary corticotroph adenoma by upregulating Wnt signaling. Ren J, Jian F, Jiang H, Sun Y, Pan S, Gu C, Chen X, Wang W, Ning G, Bian L, Sun Q. Int J Oncol. 2018 Jun;52(6):1934-1946. doi: 10.3892/ijo.2018.4355. Epub 2018 Apr 3. PubMed |
| Impact of Nrf2 on tumour growth and drug sensitivity in oncogenic K-ras-transformed cells in vitro and in vivo. Shao J, Glorieux C, Liao J, Chen P, Lu W, Liang Z, Wen S, Hu Y, Huang P. Free Radic Res. 2018 Jun;52(6):661-671. doi: 10.1080/10715762.2018.1462494. Epub 2018 May 3. PubMed |
| The YAP/TAZ transcriptional co-activators have opposing effects at different stages of osteoblast differentiation. Xiong J, Almeida M, O'Brien CA. Bone. 2018 Jul;112:1-9. doi: 10.1016/j.bone.2018.04.001. Epub 2018 Apr 4. PubMed |
| Disruption of NSD1 in Head and Neck Cancer Promotes Favorable Chemotherapeutic Responses Linked to Hypomethylation. Bui N, Huang JK, Bojorquez-Gomez A, Licon K, Sanchez KS, Tang SN, Beckett AN, Wang T, Zhang W, Shen JP, Kreisberg JF, Ideker T. Mol Cancer Ther. 2018 Jul;17(7):1585-1594. doi: 10.1158/1535-7163.MCT-17-0937. Epub 2018 Apr 10. PubMed |
| The MEF2 transcriptional target DMPK induces loss of sarcomere structure and cardiomyopathy. Damanafshan A, Elzenaar I, Samson-Couterie B, van der Made I, Bourajjaj M, van den Hoogenhof MM, van Veen HA, Picavet DI, Beqqali A, Ehler E, De Windt LJ, Pinto YM, van Oort RJ. Cardiovasc Res. 2018 Sep 1;114(11):1474-1486. doi: 10.1093/cvr/cvy091. PubMed |
| The Forkhead Transcription Factor FOXC2 Is Required for Maintaining Murine Spermatogonial Stem Cells. Wei C, Lin H, Cui S. Stem Cells Dev. 2018 May 1;27(9):624-636. doi: 10.1089/scd.2017.0233. Epub 2018 Apr 26. PubMed |
| HSP27 is a partner of JAK2-STAT5 and a potential therapeutic target in myelofibrosis. Sevin M, Kubovcakova L, Pernet N, Causse S, Vitte F, Villeval JL, Lacout C, Cordonnier M, Rodrigues-Lima F, Chanteloup G, Mosca M, Chretien ML, Bastie JN, Audia S, Sagot P, Ramla S, Martin L, Gleave M, Mezger V, Skoda R, Plo I, Garrido C, Girodon F, de Thonel A. Nat Commun. 2018 Apr 12;9(1):1431. doi: 10.1038/s41467-018-03627-9. PubMed |
| AKAPs-PKA disruptors increase AQP2 activity independently of vasopressin in a model of nephrogenic diabetes insipidus. Ando F, Mori S, Yui N, Morimoto T, Nomura N, Sohara E, Rai T, Sasaki S, Kondo Y, Kagechika H, Uchida S. Nat Commun. 2018 Apr 12;9(1):1411. doi: 10.1038/s41467-018-03771-2. PubMed |
| CD10 inhibits cell motility but expression is associated with advanced stage disease in colorectal cancer. Raposo TP, Comes MS, Idowu A, Agit B, Hassall J, Fadhil W, Nica R, Ecker R, Yao T, Ilyas M. Exp Mol Pathol. 2018 Jun;104(3):190-198. doi: 10.1016/j.yexmp.2018.04.002. Epub 2018 Apr 11. PubMed |
| Nucleic acid-induced potentiation of matrix metalloproteinase-9 enzymatic activity. Duellman T, Chen X, Wakamiya R, Yang J. Biochem J. 2018 May 9;475(9):1597-1610. doi: 10.1042/BCJ20180035. PubMed |
| hTERT gene knockdown enhances response to radio- and chemotherapy in head and neck cancer cell lines through a DNA damage pathway modification. Barczak W, Sobecka A, Golusinski P, Masternak MM, Rubis B, Suchorska WM, Golusinski W. Sci Rep. 2018 Apr 13;8(1):5949. doi: 10.1038/s41598-018-24503-y. PubMed |
| Metformin alleviates human cellular aging by upregulating the endoplasmic reticulum glutathione peroxidase 7. Fang J, Yang J, Wu X, Zhang G, Li T, Wang X, Zhang H, Wang CC, Liu GH, Wang L. Aging Cell. 2018 Apr 16:e12765. doi: 10.1111/acel.12765. PubMed |
| ARID1A ablation leads to multiple drug resistance in ovarian cancer via transcriptional activation of MRP2. Luo Q, Wu X, Zhang Y, Shu T, Ding F, Chen H, Zhao P, Chang W, Zhu X, Liu Z. Cancer Lett. 2018 Jul 28;427:9-17. doi: 10.1016/j.canlet.2018.04.013. Epub 2018 Apr 13. PubMed |
| Fank1 and Jazf1 promote multiciliated cell differentiation in the mouse airway epithelium. Johnson JA, Watson JK, Nikolic MZ, Rawlins EL. Biol Open. 2018 Apr 16;7(4). pii: 7/4/bio033944. doi: 10.1242/bio.033944. PubMed |
| lincRNA-Cox2 regulates NLRP3 inflammasome and autophagy mediated neuroinflammation. Xue Z, Zhang Z, Liu H, Li W, Guo X, Zhang Z, Liu Y, Jia L, Li Y, Ren Y, Yang H, Zhang L, Zhang Q, Da Y, Hao J, Yao Z, Zhang R. Cell Death Differ. 2019 Jan;26(1):130-145. doi: 10.1038/s41418-018-0105-8. Epub 2018 Apr 17. PubMed |
| Methylation-induced silencing of SPG20 facilitates gastric cancer cell proliferation by activating the EGFR/MAPK pathway. Zhou Z, Wang W, Xie X, Song Y, Dang C, Zhang H. Biochem Biophys Res Commun. 2018 Jun 2;500(2):411-417. doi: 10.1016/j.bbrc.2018.04.089. Epub 2018 Apr 18. PubMed |
| An Integrated Genome-wide CRISPRa Approach to Functionalize lncRNAs in Drug Resistance. Bester AC, Lee JD, Chavez A, Lee YR, Nachmani D, Vora S, Victor J, Sauvageau M, Monteleone E, Rinn JL, Provero P, Church GM, Clohessy JG, Pandolfi PP. Cell. 2018 Apr 19;173(3):649-664.e20. doi: 10.1016/j.cell.2018.03.052. PubMed |
| RNA Binding Protein, HuR, Regulates SCN5A Expression Through Stabilizing MEF2C transcription factor mRNA. Zhou A, Shi G, Kang GJ, Xie A, Liu H, Jiang N, Liu M, Jeong EM, Dudley SC Jr. J Am Heart Assoc. 2018 Apr 20;7(9). pii: JAHA.117.007802. doi: 10.1161/JAHA.117.007802. PubMed |
| 14-3-3 proteins regulate desmosomal adhesion via plakophilins. Rietscher K, Keil R, Jordan A, Hatzfeld M. J Cell Sci. 2018 May 22;131(10). pii: jcs.212191. doi: 10.1242/jcs.212191. PubMed |
| Targeting GLP-1 receptor trafficking to improve agonist efficacy. Jones B, Buenaventura T, Kanda N, Chabosseau P, Owen BM, Scott R, Goldin R, Angkathunyakul N, Correa IR Jr, Bosco D, Johnson PR, Piemonti L, Marchetti P, Shapiro AMJ, Cochran BJ, Hanyaloglu AC, Inoue A, Tan T, Rutter GA, Tomas A, Bloom SR. Nat Commun. 2018 Apr 23;9(1):1602. doi: 10.1038/s41467-018-03941-2. PubMed |
| Adipose-Derived Mesenchymal Stem Cell Application Combined With Fibrin Matrix Promotes Structural and Functional Recovery Following Spinal Cord Injury in Rats. Mukhamedshina YO, Akhmetzyanova ER, Kostennikov AA, Zakirova EY, Galieva LR, Garanina EE, Rogozin AA, Kiassov AP, Rizvanov AA. Front Pharmacol. 2018 Apr 10;9:343. doi: 10.3389/fphar.2018.00343. eCollection 2018. PubMed |
| Pharmacological versus genetic inhibition of heme oxygenase-1 - the comparison of metalloporphyrins, shRNA and CRISPR/Cas9 system. Mucha O, Podkalicka P, Czarnek M, Biela A, Mieczkowski M, Kachamakova-Trojanowska N, Stepniewski J, Jozkowicz A, Dulak J, Loboda A. Acta Biochim Pol. 2018;65(2):277-286. doi: 10.18388/abp.2017_2542. Epub 2018 Apr 25. PubMed |
| A High-Content Screening of Anticancer Compounds Suggests the Multiple Tyrosine Kinase Inhibitor Ponatinib for Repurposing in Neuroblastoma Therapy. Sidarovich V, De Mariano M, Aveic S, Pancher M, Adami V, Gatto P, Pizzini S, Pasini L, Croce M, Parodi F, Cimmino F, Avitabile M, Emionite L, Cilli M, Ferrini S, Pagano A, Capasso M, Quattrone A, Tonini GP, Longo L. Mol Cancer Ther. 2018 Jul;17(7):1405-1415. doi: 10.1158/1535-7163.MCT-17-0841. Epub 2018 Apr 25. PubMed |
| Regulation of calretinin in malignant mesothelioma is mediated by septin 7 binding to the CALB2 promoter. Blum W, Pecze L, Rodriguez JW, Steinauer M, Schwaller B. BMC Cancer. 2018 Apr 27;18(1):475. doi: 10.1186/s12885-018-4385-7. PubMed |
RNA-guided transcriptional silencing in vivo with S. aureus CRISPR-Cas9 repressors.
Thakore PI, Kwon JB, Nelson CE, Rouse DC, Gemberling MP, Oliver ML, Gersbach CA.
Nat Commun. 2018 Apr 26;9(1):1674. doi: 10.1038/s41467-018-04048-4.
PubMed
Associated Plasmids |
| Endometrial Mesenchymal Stem/Stromal Cells Modulate the Macrophage Response to Implanted Polyamide/Gelatin Composite Mesh in Immunocompromised and Immunocompetent Mice. Darzi S, Deane JA, Nold CA, Edwards SE, Gough DJ, Mukherjee S, Gurung S, Tan KS, Vashi AV, Werkmeister JA, Gargett CE. Sci Rep. 2018 Apr 26;8(1):6554. doi: 10.1038/s41598-018-24919-6. PubMed |
| Universal Chimeric Antigen Receptors for Multiplexed and Logical Control of T Cell Responses. Cho JH, Collins JJ, Wong WW. Cell. 2018 May 31;173(6):1426-1438.e11. doi: 10.1016/j.cell.2018.03.038. Epub 2018 Apr 26. PubMed |
| Cationic Polymer-Mediated CRISPR/Cas9 Plasmid Delivery for Genome Editing. Zhang Z, Wan T, Chen Y, Chen Y, Sun H, Cao T, Songyang Z, Tang G, Wu C, Ping Y, Xu FJ, Huang J. Macromol Rapid Commun. 2019 Mar;40(5):e1800068. doi: 10.1002/marc.201800068. Epub 2018 Apr 30. PubMed |
| A Comprehensive Procedure to Evaluate the In Vitro Performance of the Putative Hemangioblastoma Neovascularization Using the Spheroid Sprouting Assay. Wang Y, Chen D, Chen M, Ji K, Ma D, Zhou L. J Vis Exp. 2018 Apr 12;(134). doi: 10.3791/57183. PubMed |
| TRPV4 inhibition prevents paclitaxel-induced neurotoxicity in preclinical models. Boehmerle W, Huehnchen P, Lee SLL, Harms C, Endres M. Exp Neurol. 2018 Aug;306:64-75. doi: 10.1016/j.expneurol.2018.04.014. Epub 2018 Apr 30. PubMed |
| Posttranslational regulation of CYP2J2 by nitric oxide. Park JW, Lee CM, Cheng JS, Morgan ET. Free Radic Biol Med. 2018 Jun;121:149-156. doi: 10.1016/j.freeradbiomed.2018.04.576. Epub 2018 Apr 30. PubMed |
| A Raf-Competitive K-Ras Binder Can Fail to Functionally Antagonize Signaling. Kauke MJ, Tisdale AW, Kelly RL, Braun CJ, Hemann MT, Wittrup KD. Mol Cancer Ther. 2018 Aug;17(8):1773-1780. doi: 10.1158/1535-7163.MCT-17-0645. Epub 2018 May 2. PubMed |
| Oncogene Lin28B increases chemosensitivity of colon cancer cells in a let-7-independent manner. Ma L, Zhao Q, Chen W, Zhang Y. Oncol Lett. 2018 May;15(5):6975-6981. doi: 10.3892/ol.2018.8250. Epub 2018 Mar 13. PubMed |
| PRC1 Fine-tunes Gene Repression and Activation to Safeguard Skin Development and Stem Cell Specification. Cohen I, Zhao D, Bar C, Valdes VJ, Dauber-Decker KL, Nguyen MB, Nakayama M, Rendl M, Bickmore WA, Koseki H, Zheng D, Ezhkova E. Cell Stem Cell. 2018 May 3;22(5):726-739.e7. doi: 10.1016/j.stem.2018.04.005. PubMed |
| Retinoid-Sensitive Epigenetic Regulation of the Hoxb Cluster Maintains Normal Hematopoiesis and Inhibits Leukemogenesis. Qian P, De Kumar B, He XC, Nolte C, Gogol M, Ahn Y, Chen S, Li Z, Xu H, Perry JM, Hu D, Tao F, Zhao M, Han Y, Hall K, Peak A, Paulson A, Zhao C, Venkatraman A, Box A, Perera A, Haug JS, Parmely T, Li H, Krumlauf R, Li L. Cell Stem Cell. 2018 May 3;22(5):740-754.e7. doi: 10.1016/j.stem.2018.04.012. PubMed |
| RBM14 is indispensable for pluripotency maintenance and mesoderm development of mouse embryonic stem cells. Chen G, Zhang D, Zhang L, Feng G, Zhang B, Wu Y, Li W, Zhang Y, Hu B. Biochem Biophys Res Commun. 2018 Jun 18;501(1):259-265. doi: 10.1016/j.bbrc.2018.04.231. Epub 2018 May 8. PubMed |
| Differential regulation of the pro-inflammatory biomarker, YKL-40/CHI3L1, by PTEN/Phosphoinositide 3-kinase and JAK2/STAT3 pathways in glioblastoma. Wang Y, Wong CW, Yan M, Li L, Liu T, Or PM, Tsui SK, Waye MM, Chan AM. Cancer Lett. 2018 Aug 10;429:54-65. doi: 10.1016/j.canlet.2018.04.040. Epub 2018 May 3. PubMed |
| RNA Helicase DDX1 Converts RNA G-Quadruplex Structures into R-Loops to Promote IgH Class Switch Recombination. Ribeiro de Almeida C, Dhir S, Dhir A, Moghaddam AE, Sattentau Q, Meinhart A, Proudfoot NJ. Mol Cell. 2018 May 17;70(4):650-662.e8. doi: 10.1016/j.molcel.2018.04.001. Epub 2018 May 3. PubMed |
| Tissue-selective restriction of RNA editing of CaV1.3 by splicing factor SRSF9. Huang H, Kapeli K, Jin W, Wong YP, Arumugam TV, Koh JH, Srimasorn S, Mallilankaraman K, Chua JJE, Yeo GW, Soong TW. Nucleic Acids Res. 2018 Aug 21;46(14):7323-7338. doi: 10.1093/nar/gky348. PubMed |
| Identification of the Intragenomic Promoter Controlling Hepatitis E Virus Subgenomic RNA Transcription. Ding Q, Nimgaonkar I, Archer NF, Bram Y, Heller B, Schwartz RE, Ploss A. MBio. 2018 May 8;9(3). pii: mBio.00769-18. doi: 10.1128/mBio.00769-18. PubMed |
| Inhibition of Tip60 Reduces Lytic and Latent Gene Expression of Kaposi's Sarcoma-Associated Herpes Virus (KSHV) and Proliferation of KSHV-Infected Tumor Cells. Simpson S, Fiches G, Jean MJ, Dieringer M, McGuinness J, John SP, Shamay M, Desai P, Zhu J, Santoso NG. Front Microbiol. 2018 Apr 24;9:788. doi: 10.3389/fmicb.2018.00788. eCollection 2018. PubMed |
| Identification of inhibitors synergizing gemcitabine sensitivity in the squamous subtype of pancreatic ductal adenocarcinoma (PDAC). Er JL, Goh PN, Lee CY, Tan YJ, Hii LW, Mai CW, Chung FF, Leong CO. Apoptosis. 2018 Jun;23(5-6):343-355. doi: 10.1007/s10495-018-1459-6. PubMed |
| Identification of a transporter complex responsible for the cytosolic entry of nitrogen-containing bisphosphonates. Yu Z, Surface LE, Park CY, Horlbeck MA, Wyant GA, Abu-Remaileh M, Peterson TR, Sabatini DM, Weissman JS, O'Shea EK. Elife. 2018 May 10;7. pii: 36620. doi: 10.7554/eLife.36620. PubMed |
| TGF-beta induces miR-100 and miR-125b but blocks let-7a through LIN28B controlling PDAC progression. Ottaviani S, Stebbing J, Frampton AE, Zagorac S, Krell J, de Giorgio A, Trabulo SM, Nguyen VTM, Magnani L, Feng H, Giovannetti E, Funel N, Gress TM, Jiao LR, Lombardo Y, Lemoine NR, Heeschen C, Castellano L. Nat Commun. 2018 May 10;9(1):1845. doi: 10.1038/s41467-018-03962-x. PubMed |
| Specific targeting of point mutations in EGFR L858R-positive lung cancer by CRISPR/Cas9. Cheung AH, Chow C, Zhang J, Zhou Y, Huang T, Ng KC, Or TC, Yao YY, Dong Y, Fung JM, Xiong L, Chan AK, Lung WR, Kang W, To KF. Lab Invest. 2018 Jul;98(7):968-976. doi: 10.1038/s41374-018-0056-1. Epub 2018 May 10. PubMed |
| Generation of hepatocyte- and endocrine pancreatic-like cells from human induced endodermal progenitor cells. Sambathkumar R, Akkerman R, Dastidar S, Roelandt P, Kumar M, Bajaj M, Mestre Rosa AR, Helsen N, Vanslembrouck V, Kalo E, Khurana S, Laureys J, Gysemans C, Faas MM, de Vos P, Verfaillie CM. PLoS One. 2018 May 11;13(5):e0197046. doi: 10.1371/journal.pone.0197046. eCollection 2018. PubMed |
| Genetic Engineering of Mesenchymal Stem Cells for Differential Matrix Deposition on 3D Woven Scaffolds. Huynh NPT, Brunger JM, Gloss CC, Moutos FT, Gersbach CA, Guilak F. Tissue Eng Part A. 2018 Oct;24(19-20):1531-1544. doi: 10.1089/ten.TEA.2017.0510. Epub 2018 Jul 13. PubMed |
| Regulation of BDNF Release by ARMS/Kidins220 through Modulation of Synaptotagmin-IV Levels. Lopez-Benito S, Sanchez-Sanchez J, Brito V, Calvo L, Lisa S, Torres-Valle M, Palko ME, Vicente-Garcia C, Fernandez-Fernandez S, Bolanos JP, Gines S, Tessarollo L, Arevalo JC. J Neurosci. 2018 Jun 6;38(23):5415-5428. doi: 10.1523/JNEUROSCI.1653-17.2018. Epub 2018 May 16. PubMed |
| Mxra8 is a receptor for multiple arthritogenic alphaviruses. Zhang R, Kim AS, Fox JM, Nair S, Basore K, Klimstra WB, Rimkunas R, Fong RH, Lin H, Poddar S, Crowe JE Jr, Doranz BJ, Fremont DH, Diamond MS. Nature. 2018 May;557(7706):570-574. doi: 10.1038/s41586-018-0121-3. Epub 2018 May 16. PubMed |
| Caspase-3 Regulates YAP-Dependent Cell Proliferation and Organ Size. Yosefzon Y, Soteriou D, Feldman A, Kostic L, Koren E, Brown S, Ankawa R, Sedov E, Glaser F, Fuchs Y. Mol Cell. 2018 May 17;70(4):573-587.e4. doi: 10.1016/j.molcel.2018.04.019. PubMed |
| The Bicarbonate Transporter SLC4A7 Plays a Key Role in Macrophage Phagosome Acidification. Sedlyarov V, Eichner R, Girardi E, Essletzbichler P, Goldmann U, Nunes-Hasler P, Srndic I, Moskovskich A, Heinz LX, Kartnig F, Bigenzahn JW, Rebsamen M, Kovarik P, Demaurex N, Superti-Furga G. Cell Host Microbe. 2018 Jun 13;23(6):766-774.e5. doi: 10.1016/j.chom.2018.04.013. Epub 2018 May 17. PubMed |
| Moderate UV Exposure Enhances Learning and Memory by Promoting a Novel Glutamate Biosynthetic Pathway in the Brain. Zhu H, Wang N, Yao L, Chen Q, Zhang R, Qian J, Hou Y, Guo W, Fan S, Liu S, Zhao Q, Du F, Zuo X, Guo Y, Xu Y, Li J, Xue T, Zhong K, Song X, Huang G, Xiong W. Cell. 2018 Jun 14;173(7):1716-1727.e17. doi: 10.1016/j.cell.2018.04.014. Epub 2018 May 17. PubMed |
| The NOTCH1/CD44 axis drives pathogenesis in a T cell acute lymphoblastic leukemia model. Garcia-Peydro M, Fuentes P, Mosquera M, Garcia-Leon MJ, Alcain J, Rodriguez A, Garcia de Miguel P, Menendez P, Weijer K, Spits H, Scadden DT, Cuesta-Mateos C, Munoz-Calleja C, Sanchez-Madrid F, Toribio ML. J Clin Invest. 2018 Jul 2;128(7):2802-2818. doi: 10.1172/JCI92981. Epub 2018 May 21. PubMed |
| Targeting the upstream transcriptional activator of PD-L1 as an alternative strategy in melanoma therapy. Zhu B, Tang L, Chen S, Yin C, Peng S, Li X, Liu T, Liu W, Han C, Stawski L, Xu ZX, Zhou G, Chen X, Gao X, Goding CR, Xu N, Cui R, Cao P. Oncogene. 2018 Sep;37(36):4941-4954. doi: 10.1038/s41388-018-0314-0. Epub 2018 May 22. PubMed |
| High-Titer Production of HIV-Based Lentiviral Vectors in Roller Bottles for Gene and Cell Therapy. Olgun HB, Tasyurek HM, Sanlioglu AD, Sanlioglu S. Methods Mol Biol. 2019;1879:323-345. doi: 10.1007/7651_2018_150. PubMed |
| Reduced Abeta secretion by human neurons under conditions of strongly increased BACE activity. Scholz D, Chernyshova Y, Uckert AK, Leist M. J Neurochem. 2018 Oct;147(2):256-274. doi: 10.1111/jnc.14467. Epub 2018 Sep 26. PubMed |
| Polyglutamine binding protein 1 (PQBP1) inhibits innate immune responses to cytosolic DNA. Shannon JL, Murphy MS, Kantheti U, Burnett JM, Hahn MG, Dorrity TJ, Bacas CJ, Mattice EB, Corpuz KD, Barker BR. Mol Immunol. 2018 Jul;99:182-190. doi: 10.1016/j.molimm.2018.05.014. Epub 2018 May 26. PubMed |
| IP6 is an HIV pocket factor that prevents capsid collapse and promotes DNA synthesis. Mallery DL, Marquez CL, McEwan WA, Dickson CF, Jacques DA, Anandapadamanaban M, Bichel K, Towers GJ, Saiardi A, Bocking T, James LC. Elife. 2018 May 31;7. pii: 35335. doi: 10.7554/eLife.35335. PubMed |
| Smc5/6 Antagonism by HBx Is an Evolutionarily Conserved Function of Hepatitis B Virus Infection in Mammals. Abdul F, Filleton F, Gerossier L, Paturel A, Hall J, Strubin M, Etienne L. J Virol. 2018 Jul 31;92(16). pii: JVI.00769-18. doi: 10.1128/JVI.00769-18. Print 2018 Aug 15. PubMed |
| Partial Inactivation of the Chromatin Remodelers SMARCA2 and SMARCA4 in Virus-Infected Cells by Caspase-Mediated Cleavage. Dudek AH, Pfaff F, Bolte H, Waguia Kontchou C, Schwemmle M. J Virol. 2018 Jul 31;92(16). pii: JVI.00343-18. doi: 10.1128/JVI.00343-18. Print 2018 Aug 15. PubMed |
| CRISPR/Cas9 Genome Editing of Epidermal Growth Factor Receptor Sufficiently Abolished Oncogenicity in Anaplastic Thyroid Cancer. Huang LC, Tam KW, Liu WN, Lin CY, Hsu KW, Hsieh WS, Chi WM, Lee AW, Yang JM, Lin CL, Lee CH. Dis Markers. 2018 Apr 12;2018:3835783. doi: 10.1155/2018/3835783. eCollection 2018. PubMed |
Human-Specific NOTCH2NL Genes Expand Cortical Neurogenesis through Delta/Notch Regulation.
Suzuki IK, Gacquer D, Van Heurck R, Kumar D, Wojno M, Bilheu A, Herpoel A, Lambert N, Cheron J, Polleux F, Detours V, Vanderhaeghen P.
Cell. 2018 May 31;173(6):1370-1384.e16. doi: 10.1016/j.cell.2018.03.067. Epub 2018 May 31.
PubMed
Associated Plasmids |
| Insights into the mechanisms underlying the inactivation of HIV-1 proviruses by CRISPR/Cas. Mefferd AL, Bogerd HP, Irwan ID, Cullen BR. Virology. 2018 Jul;520:116-126. doi: 10.1016/j.virol.2018.05.016. Epub 2018 May 29. PubMed |
| PAK1 regulates ATXN1 levels providing an opportunity to modify its toxicity in spinocerebellar ataxia type 1. Bondar VV, Adamski CJ, Onur TS, Tan Q, Wang L, Diaz-Garcia J, Park J, Orr HT, Botas J, Zoghbi HY. Hum Mol Genet. 2018 Aug 15;27(16):2863-2873. doi: 10.1093/hmg/ddy200. PubMed |
| Methylation of hypoxia-inducible factor (HIF)-1alpha by G9a/GLP inhibits HIF-1 transcriptional activity and cell migration. Bao L, Chen Y, Lai HT, Wu SY, Wang JE, Hatanpaa KJ, Raisanen JM, Fontenot M, Lega B, Chiang CM, Semenza GL, Wang Y, Luo W. Nucleic Acids Res. 2018 Jul 27;46(13):6576-6591. doi: 10.1093/nar/gky449. PubMed |
| Specificity of RNAi, LNA and CRISPRi as loss-of-function methods in transcriptional analysis. Stojic L, Lun ATL, Mangei J, Mascalchi P, Quarantotti V, Barr AR, Bakal C, Marioni JC, Gergely F, Odom DT. Nucleic Acids Res. 2018 Jul 6;46(12):5950-5966. doi: 10.1093/nar/gky437. PubMed |
Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR.
Walton ZE, Patel CH, Brooks RC, Yu Y, Ibrahim-Hashim A, Riddle M, Porcu A, Jiang T, Ecker BL, Tameire F, Koumenis C, Weeraratna AT, Welsh DK, Gillies R, Alwine JC, Zhang L, Powell JD, Dang CV.
Cell. 2018 Jun 28;174(1):72-87.e32. doi: 10.1016/j.cell.2018.05.009. Epub 2018 May 31.
PubMed
Associated Plasmids |
Chimeric antigen receptors that trigger phagocytosis.
Morrissey MA, Williamson AP, Steinbach AM, Roberts EW, Kern N, Headley MB, Vale R.
Elife. 2018 Jun 4;7. pii: 36688. doi: 10.7554/eLife.36688.
PubMed
Associated Plasmids |
| Gastrointestinal stromal tumor enhancers support a transcription factor network predictive of clinical outcome. Hemming ML, Lawlor MA, Zeid R, Lesluyes T, Fletcher JA, Raut CP, Sicinska ET, Chibon F, Armstrong SA, Demetri GD, Bradner JE. Proc Natl Acad Sci U S A. 2018 Jun 19;115(25):E5746-E5755. doi: 10.1073/pnas.1802079115. Epub 2018 Jun 4. PubMed |
| Temozolomide lymphodepletion enhances CAR abundance and correlates with antitumor efficacy against established glioblastoma. Suryadevara CM, Desai R, Abel ML, Riccione KA, Batich KA, Shen SH, Chongsathidkiet P, Gedeon PC, Elsamadicy AA, Snyder DJ, Herndon JE 2nd, Healy P, Archer GE, Choi BD, Fecci PE, Sampson JH, Sanchez-Perez L. Oncoimmunology. 2018 Feb 21;7(6):e1434464. doi: 10.1080/2162402X.2018.1434464. eCollection 2018. PubMed |
| Folate receptor 1 (FOLR1) targeted chimeric antigen receptor (CAR) T cells for the treatment of gastric cancer. Kim M, Pyo S, Kang CH, Lee CO, Lee HK, Choi SU, Park CH. PLoS One. 2018 Jun 6;13(6):e0198347. doi: 10.1371/journal.pone.0198347. eCollection 2018. PubMed |
| Frequent sgRNA-barcode recombination in single-cell perturbation assays. Xie S, Cooley A, Armendariz D, Zhou P, Hon GC. PLoS One. 2018 Jun 6;13(6):e0198635. doi: 10.1371/journal.pone.0198635. eCollection 2018. PubMed |
| Kaposi's Sarcoma-Associated Herpesvirus ORF68 Is a DNA Binding Protein Required for Viral Genome Cleavage and Packaging. Gardner MR, Glaunsinger BA. J Virol. 2018 Jul 31;92(16). pii: JVI.00840-18. doi: 10.1128/JVI.00840-18. Print 2018 Aug 15. PubMed |
| Pharmacological inhibition of dihydroorotate dehydrogenase induces apoptosis and differentiation in acute myeloid leukemia cells. Wu D, Wang W, Chen W, Lian F, Lang L, Huang Y, Xu Y, Zhang N, Chen Y, Liu M, Nussinov R, Cheng F, Lu W, Huang J. Haematologica. 2018 Sep;103(9):1472-1483. doi: 10.3324/haematol.2018.188185. Epub 2018 Jun 7. PubMed |
| The transcription factor Zfp90 regulates the self-renewal and differentiation of hematopoietic stem cells. Liu T, Kong WX, Tang XY, Xu M, Wang QH, Zhang B, Hu LD, Chen H. Cell Death Dis. 2018 Jun 7;9(6):677. doi: 10.1038/s41419-018-0721-8. PubMed |
A Network of Noncoding Regulatory RNAs Acts in the Mammalian Brain.
Kleaveland B, Shi CY, Stefano J, Bartel DP.
Cell. 2018 Jul 12;174(2):350-362.e17. doi: 10.1016/j.cell.2018.05.022. Epub 2018 Jun 7.
PubMed
Associated Plasmids |
| Nicotinamide adenine dinucleotide is transported into mammalian mitochondria. Davila A, Liu L, Chellappa K, Redpath P, Nakamaru-Ogiso E, Paolella LM, Zhang Z, Migaud ME, Rabinowitz JD, Baur JA. Elife. 2018 Jun 12;7. pii: 33246. doi: 10.7554/eLife.33246. PubMed |
| An immortalised mesenchymal stem cell line maintains mechano-responsive behaviour and can be used as a reporter of substrate stiffness. Galarza Torre A, Shaw JE, Wood A, Gilbert HTJ, Dobre O, Genever P, Brennan K, Richardson SM, Swift J. Sci Rep. 2018 Jun 12;8(1):8981. doi: 10.1038/s41598-018-27346-9. PubMed |
| Telomerase reverse transcriptase interference synergistically promotes tumor necrosis factorrelated apoptosisinducing ligandinduced oral squamous cell carcinoma apoptosis and suppresses proliferation in vitro and in vivo. Zhao X, Zhang C, Le Z, Zeng S, Pan C, Shi J, Wang J, Zhao X. Int J Mol Med. 2018 Sep;42(3):1283-1294. doi: 10.3892/ijmm.2018.3721. Epub 2018 Jun 7. PubMed |
| Data on mass spectrometry-based proteomics for studying the involvement of CYLD in the ubiquitination events downstream of EGFR activation. Sanchez-Quiles V, Osinalde N, Akimov V, Kratchmarova I, Blagoev B. Data Brief. 2018 Apr 25;18:1856-1863. doi: 10.1016/j.dib.2018.04.049. eCollection 2018 Jun. PubMed |
| Activity-Dependent Actin Remodeling at the Base of Dendritic Spines Promotes Microtubule Entry. Schatzle P, Esteves da Silva M, Tas RP, Katrukha EA, Hu HY, Wierenga CJ, Kapitein LC, Hoogenraad CC. Curr Biol. 2018 Jul 9;28(13):2081-2093.e6. doi: 10.1016/j.cub.2018.05.004. Epub 2018 Jun 14. PubMed |
| Cryptic exon splicing function of TARDBP interacts with autophagy in nervous tissue. Torres P, Ramirez-Nunez O, Romero-Guevara R, Bares G, Granado-Serrano AB, Ayala V, Boada J, Fontdevila L, Povedano M, Sanchis D, Pamplona R, Ferrer I, Portero-Otin M. Autophagy. 2018;14(8):1398-1403. doi: 10.1080/15548627.2018.1474311. Epub 2018 Jul 28. PubMed |
| Trehalose reduces retinal degeneration, neuroinflammation and storage burden caused by a lysosomal hydrolase deficiency. Lotfi P, Tse DY, Di Ronza A, Seymour ML, Martano G, Cooper JD, Pereira FA, Passafaro M, Wu SM, Sardiello M. Autophagy. 2018;14(8):1419-1434. doi: 10.1080/15548627.2018.1474313. Epub 2018 Jul 23. PubMed |
| Regulation of Epithelial Plasticity Determines Metastatic Organotropism in Pancreatic Cancer. Reichert M, Bakir B, Moreira L, Pitarresi JR, Feldmann K, Simon L, Suzuki K, Maddipati R, Rhim AD, Schlitter AM, Kriegsmann M, Weichert W, Wirth M, Schuck K, Schneider G, Saur D, Reynolds AB, Klein-Szanto AJ, Pehlivanoglu B, Memis B, Adsay NV, Rustgi AK. Dev Cell. 2018 Jun 18;45(6):696-711.e8. doi: 10.1016/j.devcel.2018.05.025. PubMed |
Transcription Factor-Mediated Differentiation of Human iPSCs into Neurons.
Fernandopulle MS, Prestil R, Grunseich C, Wang C, Gan L, Ward ME.
Curr Protoc Cell Biol. 2018 Jun;79(1):e51. doi: 10.1002/cpcb.51. Epub 2018 May 18.
PubMed
Associated Plasmids |
| A multiprotein supercomplex controlling oncogenic signalling in lymphoma. Phelan JD, Young RM, Webster DE, Roulland S, Wright GW, Kasbekar M, Shaffer AL 3rd, Ceribelli M, Wang JQ, Schmitz R, Nakagawa M, Bachy E, Huang DW, Ji Y, Chen L, Yang Y, Zhao H, Yu X, Xu W, Palisoc MM, Valadez RR, Davies-Hill T, Wilson WH, Chan WC, Jaffe ES, Gascoyne RD, Campo E, Rosenwald A, Ott G, Delabie J, Rimsza LM, Rodriguez FJ, Estephan F, Holdhoff M, Kruhlak MJ, Hewitt SM, Thomas CJ, Pittaluga S, Oellerich T, Staudt LM. Nature. 2018 Aug;560(7718):387-391. doi: 10.1038/s41586-018-0290-0. Epub 2018 Jun 20. PubMed |
| Flap endonuclease 1 is involved in cccDNA formation in the hepatitis B virus. Kitamura K, Que L, Shimadu M, Koura M, Ishihara Y, Wakae K, Nakamura T, Watashi K, Wakita T, Muramatsu M. PLoS Pathog. 2018 Jun 21;14(6):e1007124. doi: 10.1371/journal.ppat.1007124. eCollection 2018 Jun. PubMed |
| X chromosome protects against bladder cancer in females via a KDM6A-dependent epigenetic mechanism. Kaneko S, Li X. Sci Adv. 2018 Jun 13;4(6):eaar5598. doi: 10.1126/sciadv.aar5598. eCollection 2018 Jun. PubMed |
| NEK1 loss-of-function mutation induces DNA damage accumulation in ALS patient-derived motoneurons. Higelin J, Catanese A, Semelink-Sedlacek LL, Oeztuerk S, Lutz AK, Bausinger J, Barbi G, Speit G, Andersen PM, Ludolph AC, Demestre M, Boeckers TM. Stem Cell Res. 2018 Jul;30:150-162. doi: 10.1016/j.scr.2018.06.005. Epub 2018 Jun 12. PubMed |
| Transbilayer phospholipid movement facilitates the translocation of annexin across membranes. Stewart SE, Ashkenazi A, Williamson A, Rubinsztein DC, Moreau K. J Cell Sci. 2018 Jul 19;131(14). pii: jcs.217034. doi: 10.1242/jcs.217034. PubMed |
| A Ca(2+)-stimulated exosome release pathway in cancer cells is regulated by Munc13-4. Messenger SW, Woo SS, Sun Z, Martin TFJ. J Cell Biol. 2018 Aug 6;217(8):2877-2890. doi: 10.1083/jcb.201710132. Epub 2018 Jun 21. PubMed |
| Apoptotic Cell-Derived Extracellular Vesicles Promote Malignancy of Glioblastoma Via Intercellular Transfer of Splicing Factors. Pavlyukov MS, Yu H, Bastola S, Minata M, Shender VO, Lee Y, Zhang S, Wang J, Komarova S, Wang J, Yamaguchi S, Alsheikh HA, Shi J, Chen D, Mohyeldin A, Kim SH, Shin YJ, Anufrieva K, Evtushenko EG, Antipova NV, Arapidi GP, Govorun V, Pestov NB, Shakhparonov MI, Lee LJ, Nam DH, Nakano I. Cancer Cell. 2018 Jul 9;34(1):119-135.e10. doi: 10.1016/j.ccell.2018.05.012. Epub 2018 Jun 21. PubMed |
| An in vivo model for thyroid regeneration and folliculogenesis. Iwadate M, Takizawa Y, Shirai YT, Kimura S. Lab Invest. 2018 Sep;98(9):1126-1132. doi: 10.1038/s41374-018-0068-x. Epub 2018 Jun 26. PubMed |
| Epstein-Barr virus-encoded EBNA2 alters immune checkpoint PD-L1 expression by downregulating miR-34a in B-cell lymphomas. Anastasiadou E, Stroopinsky D, Alimperti S, Jiao AL, Pyzer AR, Cippitelli C, Pepe G, Severa M, Rosenblatt J, Etna MP, Rieger S, Kempkes B, Coccia EM, Sui SJH, Chen CS, Uccini S, Avigan D, Faggioni A, Trivedi P, Slack FJ. Leukemia. 2019 Jan;33(1):132-147. doi: 10.1038/s41375-018-0178-x. Epub 2018 Jun 26. PubMed |
Multimodal cell tracking from systemic administration to tumour growth by combining gold nanorods and reporter genes.
Comenge J, Sharkey J, Fragueiro O, Wilm B, Brust M, Murray P, Levy R, Plagge A.
Elife. 2018 Jun 27;7. pii: 33140. doi: 10.7554/eLife.33140.
PubMed
Associated Plasmids |
| Transcription factor NFE2L2/NRF2 modulates chaperone-mediated autophagy through the regulation of LAMP2A. Pajares M, Rojo AI, Arias E, Diaz-Carretero A, Cuervo AM, Cuadrado A. Autophagy. 2018;14(8):1310-1322. doi: 10.1080/15548627.2018.1474992. Epub 2018 Jul 26. PubMed |
| Keratinocyte differentiation induces APOBEC3A, 3B, and mitochondrial DNA hypermutation. Wakae K, Nishiyama T, Kondo S, Izuka T, Que L, Chen C, Kase K, Kitamura K, Mohiuddin M, Wang Z, Ahasan MM, Nakamura M, Fujiwara H, Yoshizaki T, Hosomochi K, Tajima A, Nakahara T, Kiyono T, Muramatsu M. Sci Rep. 2018 Jun 27;8(1):9745. doi: 10.1038/s41598-018-27930-z. PubMed |
| Reprogramming the murine colon cancer microenvironment using lentivectors encoding shRNA against IL-10 as a component of a potent DC-based chemoimmunotherapy. Rossowska J, Anger N, Szczygiel A, Mierzejewska J, Pajtasz-Piasecka E. J Exp Clin Cancer Res. 2018 Jun 28;37(1):126. doi: 10.1186/s13046-018-0799-y. PubMed |
| Promoter interactome of human embryonic stem cell-derived cardiomyocytes connects GWAS regions to cardiac gene networks. Choy MK, Javierre BM, Williams SG, Baross SL, Liu Y, Wingett SW, Akbarov A, Wallace C, Freire-Pritchett P, Rugg-Gunn PJ, Spivakov M, Fraser P, Keavney BD. Nat Commun. 2018 Jun 28;9(1):2526. doi: 10.1038/s41467-018-04931-0. PubMed |
| CBFbeta-SMMHC Inhibition Triggers Apoptosis by Disrupting MYC Chromatin Dynamics in Acute Myeloid Leukemia. Pulikkan JA, Hegde M, Ahmad HM, Belaghzal H, Illendula A, Yu J, O'Hagan K, Ou J, Muller-Tidow C, Wolfe SA, Zhu LJ, Dekker J, Bushweller JH, Castilla LH. Cell. 2018 Jun 28;174(1):172-186.e21. doi: 10.1016/j.cell.2018.05.048. PubMed |
| Four Key Steps Control Glycolytic Flux in Mammalian Cells. Tanner LB, Goglia AG, Wei MH, Sehgal T, Parsons LR, Park JO, White E, Toettcher JE, Rabinowitz JD. Cell Syst. 2018 Jul 25;7(1):49-62.e8. doi: 10.1016/j.cels.2018.06.003. Epub 2018 Jun 27. PubMed |
| IKZF1 Enhances Immune Infiltrate Recruitment in Solid Tumors and Susceptibility to Immunotherapy. Chen JC, Perez-Lorenzo R, Saenger YM, Drake CG, Christiano AM. Cell Syst. 2018 Jul 25;7(1):92-103.e4. doi: 10.1016/j.cels.2018.05.020. Epub 2018 Jun 27. PubMed |
| miR-876-3p regulates glucose homeostasis and insulin sensitivity by targeting adiponectin. Rajan S, Panzade G, Srivastava A, Shankar K, Pandey R, Kumar D, Gupta S, Gupta A, Varshney S, Beg M, Mishra RK, Shankar R, Gaikwad AN. J Endocrinol. 2018 Jul 2. pii: JOE-17-0387. doi: 10.1530/JOE-17-0387. PubMed |
| Synthetic far-red light-mediated CRISPR-dCas9 device for inducing functional neuronal differentiation. Shao J, Wang M, Yu G, Zhu S, Yu Y, Heng BC, Wu J, Ye H. Proc Natl Acad Sci U S A. 2018 Jul 17;115(29):E6722-E6730. doi: 10.1073/pnas.1802448115. Epub 2018 Jul 2. PubMed |
| MicroRNAs Overcome Cell Fate Barrier by Reducing EZH2-Controlled REST Stability during Neuronal Conversion of Human Adult Fibroblasts. Lee SW, Oh YM, Lu YL, Kim WK, Yoo AS. Dev Cell. 2018 Jul 2;46(1):73-84.e7. doi: 10.1016/j.devcel.2018.06.007. PubMed |
| Activation of the endoplasmic reticulum stress sensor IRE1alpha by the vaccine adjuvant AS03 contributes to its immunostimulatory properties. Givord C, Welsby I, Detienne S, Thomas S, Assabban A, Lima Silva V, Molle C, Gineste R, Vermeersch M, Perez-Morga D, Leo O, Collignon C, Didierlaurent AM, Goriely S. NPJ Vaccines. 2018 Jun 28;3:20. doi: 10.1038/s41541-018-0058-4. eCollection 2018. PubMed |
| Transcription factor induced conversion of human fibroblasts towards the hair cell lineage. Duran Alonso MB, Lopez Hernandez I, de la Fuente MA, Garcia-Sancho J, Giraldez F, Schimmang T. PLoS One. 2018 Jul 6;13(7):e0200210. doi: 10.1371/journal.pone.0200210. eCollection 2018. PubMed |
| Mapping Active Gene-Regulatory Regions in Human Repopulating Long-Term HSCs. Wunsche P, Eckert ESP, Holland-Letz T, Paruzynski A, Hotz-Wagenblatt A, Fronza R, Rath T, Gil-Farina I, Schmidt M, von Kalle C, Klein C, Ball CR, Herbst F, Glimm H. Cell Stem Cell. 2018 Jul 5;23(1):132-146.e9. doi: 10.1016/j.stem.2018.06.003. PubMed |
| MicroRNA-132 provides neuroprotection for tauopathies via multiple signaling pathways. El Fatimy R, Li S, Chen Z, Mushannen T, Gongala S, Wei Z, Balu DT, Rabinovsky R, Cantlon A, Elkhal A, Selkoe DJ, Sonntag KC, Walsh DM, Krichevsky AM. Acta Neuropathol. 2018 Oct;136(4):537-555. doi: 10.1007/s00401-018-1880-5. Epub 2018 Jul 7. PubMed |
| Angiotropism and extravascular migratory metastasis in cutaneous and uveal melanoma progression in a zebrafish model. Fornabaio G, Barnhill RL, Lugassy C, Bentolila LA, Cassoux N, Roman-Roman S, Alsafadi S, Del Bene F. Sci Rep. 2018 Jul 11;8(1):10448. doi: 10.1038/s41598-018-28515-6. PubMed |
| Myosin X is required for efficient melanoblast migration and melanoma initiation and metastasis. Tokuo H, Bhawan J, Coluccio LM. Sci Rep. 2018 Jul 11;8(1):10449. doi: 10.1038/s41598-018-28717-y. PubMed |
| Human Cytomegalovirus Tropism Modulator UL148 Interacts with SEL1L, a Cellular Factor That Governs Endoplasmic Reticulum-Associated Degradation of the Viral Envelope Glycoprotein gO. Nguyen CC, Siddiquey MNA, Zhang H, Li G, Kamil JP. J Virol. 2018 Aug 29;92(18). pii: JVI.00688-18. doi: 10.1128/JVI.00688-18. Print 2018 Sep 15. PubMed |
| Assembling the jigsaw puzzle: CBX2 isoform 2 and its targets in disorders/differences of sex development. Sproll P, Eid W, Gomes CR, Mendonca BB, Gomes NL, Costa EM, Biason-Lauber A. Mol Genet Genomic Med. 2018 Sep;6(5):785-795. doi: 10.1002/mgg3.445. Epub 2018 Jul 11. PubMed |
| Vesicular stomatitis virus G protein transmembrane region is crucial for the hemi-fusion to full fusion transition. Ci Y, Yang Y, Xu C, Shi L. Sci Rep. 2018 Jul 13;8(1):10669. doi: 10.1038/s41598-018-28868-y. PubMed |
| EZH2-Mediated Primary Cilium Deconstruction Drives Metastatic Melanoma Formation. Zingg D, Debbache J, Pena-Hernandez R, Antunes AT, Schaefer SM, Cheng PF, Zimmerli D, Haeusel J, Calcada RR, Tuncer E, Zhang Y, Bossart R, Wong KK, Basler K, Dummer R, Santoro R, Levesque MP, Sommer L. Cancer Cell. 2018 Jul 9;34(1):69-84.e14. doi: 10.1016/j.ccell.2018.06.001. Epub 2018 Jun 28. PubMed |
| Mutant ASXL1 cooperates with BAP1 to promote myeloid leukaemogenesis. Asada S, Goyama S, Inoue D, Shikata S, Takeda R, Fukushima T, Yonezawa T, Fujino T, Hayashi Y, Kawabata KC, Fukuyama T, Tanaka Y, Yokoyama A, Yamazaki S, Kozuka-Hata H, Oyama M, Kojima S, Kawazu M, Mano H, Kitamura T. Nat Commun. 2018 Jul 16;9(1):2733. doi: 10.1038/s41467-018-05085-9. PubMed |
| Deguelin attenuates non-small cell lung cancer cell metastasis through inhibiting the CtsZ/FAK signaling pathway. Li W, Yu X, Ma X, Xie L, Xia Z, Liu L, Yu X, Wang J, Zhou H, Zhou X, Yang Y, Liu H. Cell Signal. 2018 Oct;50:131-141. doi: 10.1016/j.cellsig.2018.07.001. Epub 2018 Jul 7. PubMed |
| Unique BIR domain sets determine inhibitor of apoptosis protein-driven cell death and NOD2 complex signal specificity. Chirieleison SM, Rathkey JK, Abbott DW. Sci Signal. 2018 Jul 17;11(539). pii: 11/539/eaao3964. doi: 10.1126/scisignal.aao3964. PubMed |
| Detection of Succinate by Intestinal Tuft Cells Triggers a Type 2 Innate Immune Circuit. Nadjsombati MS, McGinty JW, Lyons-Cohen MR, Jaffe JB, DiPeso L, Schneider C, Miller CN, Pollack JL, Nagana Gowda GA, Fontana MF, Erle DJ, Anderson MS, Locksley RM, Raftery D, von Moltke J. Immunity. 2018 Jul 17;49(1):33-41.e7. doi: 10.1016/j.immuni.2018.06.016. PubMed |
| MiR-129 regulates growth and invasion by targeting MAL2 in papillary thyroid carcinoma. Gao X, Chen Z, Li A, Zhang X, Cai X. Biomed Pharmacother. 2018 Sep;105:1072-1078. doi: 10.1016/j.biopha.2018.06.050. Epub 2018 Jun 19. PubMed |
| Shieldin complex promotes DNA end-joining and counters homologous recombination in BRCA1-null cells. Dev H, Chiang TW, Lescale C, de Krijger I, Martin AG, Pilger D, Coates J, Sczaniecka-Clift M, Wei W, Ostermaier M, Herzog M, Lam J, Shea A, Demir M, Wu Q, Yang F, Fu B, Lai Z, Balmus G, Belotserkovskaya R, Serra V, O'Connor MJ, Bruna A, Beli P, Pellegrini L, Caldas C, Deriano L, Jacobs JJL, Galanty Y, Jackson SP. Nat Cell Biol. 2018 Aug;20(8):954-965. doi: 10.1038/s41556-018-0140-1. Epub 2018 Jul 18. PubMed |
| Single Copy Transgene Integration in a Transcriptionally Active Site for Recombinant Protein Synthesis. O'Brien SA, Lee K, Fu HY, Lee Z, Le TS, Stach CS, McCann MG, Zhang AQ, Smanski MJ, Somia NV, Hu WS. Biotechnol J. 2018 Oct;13(10):e1800226. doi: 10.1002/biot.201800226. Epub 2018 Jul 30. PubMed |
| A genome-scale CRISPR-Cas9 screening in myeloma cells identifies regulators of immunomodulatory drug sensitivity. Liu J, Song T, Zhou W, Xing L, Wang S, Ho M, Peng Z, Tai YT, Hideshima T, Anderson KC, Cang Y. Leukemia. 2019 Jan;33(1):171-180. doi: 10.1038/s41375-018-0205-y. Epub 2018 Jul 19. PubMed |
| NAT6 acetylates the N-terminus of different forms of actin. Wiame E, Tahay G, Tyteca D, Vertommen D, Stroobant V, Bommer GT, Van Schaftingen E. FEBS J. 2018 Sep;285(17):3299-3316. doi: 10.1111/febs.14605. Epub 2018 Aug 13. PubMed |
| Risk SNP-Mediated Promoter-Enhancer Switching Drives Prostate Cancer through lncRNA PCAT19. Hua JT, Ahmed M, Guo H, Zhang Y, Chen S, Soares F, Lu J, Zhou S, Wang M, Li H, Larson NB, McDonnell SK, Patel PS, Liang Y, Yao CQ, van der Kwast T, Lupien M, Feng FY, Zoubeidi A, Tsao MS, Thibodeau SN, Boutros PC, He HH. Cell. 2018 Jul 26;174(3):564-575.e18. doi: 10.1016/j.cell.2018.06.014. Epub 2018 Jul 19. PubMed |
| MUNC, an Enhancer RNA Upstream from the MYOD Gene, Induces a Subgroup of Myogenic Transcripts in trans Independently of MyoD. Cichewicz MA, Kiran M, Przanowska RK, Sobierajska E, Shibata Y, Dutta A. Mol Cell Biol. 2018 Sep 28;38(20). pii: MCB.00655-17. doi: 10.1128/MCB.00655-17. Print 2018 Oct 15. PubMed |
| Exposure to galactic cosmic radiation compromises DNA repair and increases the potential for oncogenic chromosomal rearrangement in bronchial epithelial cells. Li Z, Jella KK, Jaafar L, Li S, Park S, Story MD, Wang H, Wang Y, Dynan WS. Sci Rep. 2018 Jul 23;8(1):11038. doi: 10.1038/s41598-018-29350-5. PubMed |
The Human Cytomegalovirus Endoplasmic Reticulum-Resident Glycoprotein UL148 Activates the Unfolded Protein Response.
Siddiquey MNA, Zhang H, Nguyen CC, Domma AJ, Kamil JP.
J Virol. 2018 Sep 26;92(20). pii: JVI.00896-18. doi: 10.1128/JVI.00896-18. Print 2018 Oct 15.
PubMed
Associated Plasmids |
| 3D-cultured neural stem cell microarrays on a micropillar chip for high-throughput developmental neurotoxicology. Joshi P, Yu KN, Kang SY, Kwon SJ, Kwon PS, Dordick JS, Kothapalli CR, Lee MY. Exp Cell Res. 2018 Sep 15;370(2):680-691. doi: 10.1016/j.yexcr.2018.07.034. Epub 2018 Jul 24. PubMed |
| Concerted ESCRT and clathrin recruitment waves define the timing and morphology of intraluminal vesicle formation. Wenzel EM, Schultz SW, Schink KO, Pedersen NM, Nahse V, Carlson A, Brech A, Stenmark H, Raiborg C. Nat Commun. 2018 Jul 26;9(1):2932. doi: 10.1038/s41467-018-05345-8. PubMed |
| Frontline Science: RIP2 promotes house dust mite-induced allergic airway inflammation. Miller MH, Shehat MG, Alcedo KP, Spinel LP, Soulakova J, Tigno-Aranjuez JT. J Leukoc Biol. 2018 Sep;104(3):447-459. doi: 10.1002/JLB.4HI0118-017RR. Epub 2018 Jul 27. PubMed |
| An Unbiased Screen for Human Cytomegalovirus Identifies Neuropilin-2 as a Central Viral Receptor. Martinez-Martin N, Marcandalli J, Huang CS, Arthur CP, Perotti M, Foglierini M, Ho H, Dosey AM, Shriver S, Payandeh J, Leitner A, Lanzavecchia A, Perez L, Ciferri C. Cell. 2018 Aug 23;174(5):1158-1171.e19. doi: 10.1016/j.cell.2018.06.028. Epub 2018 Jul 26. PubMed |
| A Phosphatidylinositol 3-Kinase Effector Alters Phagosomal Maturation to Promote Intracellular Growth of Francisella. Ledvina HE, Kelly KA, Eshraghi A, Plemel RL, Peterson SB, Lee B, Steele S, Adler M, Kawula TH, Merz AJ, Skerrett SJ, Celli J, Mougous JD. Cell Host Microbe. 2018 Aug 8;24(2):285-295.e8. doi: 10.1016/j.chom.2018.07.003. Epub 2018 Jul 26. PubMed |
| Monitoring implantable immunoisolation devices with intrinsic fluorescence of genipin. Santos-Vizcaino E, Haley H, Gonzalez-Pujana A, Orive G, Hernandez RM, Luker GD, Pedraz JL. J Biophotonics. 2019 Apr;12(4):e201800170. doi: 10.1002/jbio.201800170. Epub 2018 Sep 25. PubMed |
The actin cytoskeletal architecture of estrogen receptor positive breast cancer cells suppresses invasion.
Padilla-Rodriguez M, Parker SS, Adams DG, Westerling T, Puleo JI, Watson AW, Hill SM, Noon M, Gaudin R, Aaron J, Tong D, Roe DJ, Knudsen B, Mouneimne G.
Nat Commun. 2018 Jul 30;9(1):2980. doi: 10.1038/s41467-018-05367-2.
PubMed
Associated Plasmids |
| Programmable DNA repair with CRISPRa/i enhanced homology-directed repair efficiency with a single Cas9. Ye L, Wang C, Hong L, Sun N, Chen D, Chen S, Han F. Cell Discov. 2018 Jul 24;4:46. doi: 10.1038/s41421-018-0049-7. eCollection 2018. PubMed |
Identification of SMCHD1 domains for nuclear localization, homo-dimerization, and protein cleavage.
Hiramuki Y, Tapscott SJ.
Skelet Muscle. 2018 Aug 2;8(1):24. doi: 10.1186/s13395-018-0172-z.
PubMed
Associated Plasmids |
| JMJD2B/KDM4B inactivation in adipose tissues accelerates obesity and systemic metabolic abnormalities. Kang C, Saso K, Ota K, Kawazu M, Ueda T, Okada H. Genes Cells. 2018 Sep;23(9):767-777. doi: 10.1111/gtc.12627. Epub 2018 Aug 2. PubMed |
| CRMP4a suppresses cell motility by sequestering RhoA activity in prostate cancer cells. Li C, Xu H, Xiao L, Zhu H, Zhang G, Wei W, Li K, Cao X, Shen D, Holzbeierlein J, Li B. Cancer Biol Ther. 2018 Aug 6:1-11. doi: 10.1080/15384047.2018.1491507. PubMed |
| HDAC11 suppresses the thermogenic program of adipose tissue via BRD2. Bagchi RA, Ferguson BS, Stratton MS, Hu T, Cavasin MA, Sun L, Lin YH, Liu D, Londono P, Song K, Pino MF, Sparks LM, Smith SR, Scherer PE, Collins S, Seto E, McKinsey TA. JCI Insight. 2018 Aug 9;3(15). pii: 120159. doi: 10.1172/jci.insight.120159. eCollection 2018 Aug 9. PubMed |
| RNA binding protein HuR regulates extracellular matrix gene expression and pH homeostasis independent of controlling HIF-1alpha signaling in nucleus pulposus cells. Pan H, Strickland A, Madhu V, Johnson ZI, Chand SN, Brody JR, Fertala A, Zheng Z, Shapiro IM, Risbud MV. Matrix Biol. 2019 Apr;77:23-40. doi: 10.1016/j.matbio.2018.08.003. Epub 2018 Aug 7. PubMed |
| AIF promotes a JNK1-mediated cadherin switch independently of respiratory chain stabilization. Scott AJ, Walker SA, Krank JJ, Wilkinson AS, Johnson KM, Lewis EM, Wilkinson JC. J Biol Chem. 2018 Sep 21;293(38):14707-14722. doi: 10.1074/jbc.RA118.004022. Epub 2018 Aug 9. PubMed |
| CXCL1 Derived from Mammary Fibroblasts Promotes Progression of Mammary Lesions to Invasive Carcinoma through CXCR2 Dependent Mechanisms. Bernard S, Myers M, Fang WB, Zinda B, Smart C, Lambert D, Zou A, Fan F, Cheng N. J Mammary Gland Biol Neoplasia. 2018 Dec;23(4):249-267. doi: 10.1007/s10911-018-9407-1. Epub 2018 Aug 9. PubMed |
| Genome Editing of Human Primary Keratinocytes by CRISPR/Cas9 Reveals an Essential Role of the NLRP1 Inflammasome in UVB Sensing. Fenini G, Grossi S, Contassot E, Biedermann T, Reichmann E, French LE, Beer HD. J Invest Dermatol. 2018 Dec;138(12):2644-2652. doi: 10.1016/j.jid.2018.07.016. Epub 2018 Aug 7. PubMed |
| B lymphocyte-induced maturation protein 1 controls TH9 cell development, IL-9 production, and allergic inflammation. Benevides L, Costa RS, Tavares LA, Russo M, Martins GA, da Silva LLP, Arruda LK, Cunha FQ, Carregaro V, Silva JS. J Allergy Clin Immunol. 2019 Mar;143(3):1119-1130.e3. doi: 10.1016/j.jaci.2018.06.046. Epub 2018 Aug 7. PubMed |
| Targeting AURKA-CDC25C axis to induce synthetic lethality in ARID1A-deficient colorectal cancer cells. Wu C, Lyu J, Yang EJ, Liu Y, Zhang B, Shim JS. Nat Commun. 2018 Aug 10;9(1):3212. doi: 10.1038/s41467-018-05694-4. PubMed |
| Evaluating Nonintegrating Lentiviruses as Safe Vectors for Noninvasive Reporter-Based Molecular Imaging of Multipotent Mesenchymal Stem Cells. Hamilton AM, Foster PJ, Ronald JA. Hum Gene Ther. 2018 Oct;29(10):1213-1225. doi: 10.1089/hum.2018.111. Epub 2018 Sep 14. PubMed |
| Triggered Cell-Cell Fusion Assay for Cytoplasmic and Organelle Intermixing Studies. Feliciano D, Nixon-Abell J, Lippincott-Schwartz J. Curr Protoc Cell Biol. 2018 Dec;81(1):e61. doi: 10.1002/cpcb.61. Epub 2018 Aug 13. PubMed |
| Role of c-Myb in the regulation of natural killer cell activity. Shin HW, Lee YJ, Kim J. Biochem Biophys Res Commun. 2018 Sep 18;503(4):2807-2813. doi: 10.1016/j.bbrc.2018.08.044. Epub 2018 Aug 10. PubMed |
| SF1-Specific AMPKalpha1 Deletion Protects Against Diet-Induced Obesity. Seoane-Collazo P, Roa J, Rial-Pensado E, Linares-Pose L, Beiroa D, Ruiz-Pino F, Lopez-Gonzalez T, Morgan DA, Pardavila JA, Sanchez-Tapia MJ, Martinez-Sanchez N, Contreras C, Fidalgo M, Dieguez C, Coppari R, Rahmouni K, Nogueiras R, Tena-Sempere M, Lopez M. Diabetes. 2018 Nov;67(11):2213-2226. doi: 10.2337/db17-1538. Epub 2018 Aug 13. PubMed |
| Drug-based perturbation screen uncovers synergistic drug combinations in Burkitt lymphoma. Tomska K, Kurilov R, Lee KS, Hullein J, Lukas M, Sellner L, Walther T, Wagner L, Oles M, Brors B, Huber W, Zenz T. Sci Rep. 2018 Aug 13;8(1):12046. doi: 10.1038/s41598-018-30509-3. PubMed |
| Gambogic Acid and Its Analogs Inhibit Gap Junctional Intercellular Communication. Choi EJ, Yeo JH, Yoon SM, Lee J. Front Pharmacol. 2018 Jul 30;9:814. doi: 10.3389/fphar.2018.00814. eCollection 2018. PubMed |
Long non-coding RNA H19 regulates endothelial cell aging via inhibition of STAT3 signalling.
Hofmann P, Sommer J, Theodorou K, Kirchhof L, Fischer A, Li Y, Perisic L, Hedin U, Maegdefessel L, Dimmeler S, Boon RA.
Cardiovasc Res. 2019 Jan 1;115(1):230-242. doi: 10.1093/cvr/cvy206.
PubMed
Associated Plasmids |
| Complex bile duct network formation within liver decellularized extracellular matrix hydrogels. Lewis PL, Su J, Yan M, Meng F, Glaser SS, Alpini GD, Green RM, Sosa-Pineda B, Shah RN. Sci Rep. 2018 Aug 15;8(1):12220. doi: 10.1038/s41598-018-30433-6. PubMed |
| Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy. Logue SE, McGrath EP, Cleary P, Greene S, Mnich K, Almanza A, Chevet E, Dwyer RM, Oommen A, Legembre P, Godey F, Madden EC, Leuzzi B, Obacz J, Zeng Q, Patterson JB, Jager R, Gorman AM, Samali A. Nat Commun. 2018 Aug 15;9(1):3267. doi: 10.1038/s41467-018-05763-8. PubMed |
| Axoneme polyglutamylation regulated by Joubert syndrome protein ARL13B controls ciliary targeting of signaling molecules. He K, Ma X, Xu T, Li Y, Hodge A, Zhang Q, Torline J, Huang Y, Zhao J, Ling K, Hu J. Nat Commun. 2018 Aug 17;9(1):3310. doi: 10.1038/s41467-018-05867-1. PubMed |
| Plasmalogens Inhibit Endocytosis of Toll-like Receptor 4 to Attenuate the Inflammatory Signal in Microglial Cells. Ali F, Hossain MS, Sejimo S, Akashi K. Mol Neurobiol. 2018 Aug 20. pii: 10.1007/s12035-018-1307-2. doi: 10.1007/s12035-018-1307-2. PubMed |
| Rapamycin Upregulates Connective Tissue Growth Factor Expression in Hepatic Progenitor Cells Through TGF-beta-Smad2 Dependent Signaling. Wu Y, Wang W, Peng XM, He Y, Xiong YX, Liang HF, Chu L, Zhang BX, Ding ZY, Chen XP. Front Pharmacol. 2018 Aug 8;9:877. doi: 10.3389/fphar.2018.00877. eCollection 2018. PubMed |
| Nrf2 Signaling in Sodium Azide-Treated Oligodendrocytes Restores Mitochondrial Functions. Liessem-Schmitz A, Teske N, Scheld M, Nyamoya S, Zendedel A, Beyer C, Clarner T, Fragoulis A. J Mol Neurosci. 2018 Oct;66(2):229-237. doi: 10.1007/s12031-018-1159-2. Epub 2018 Aug 23. PubMed |
| The tuberous sclerosis complex subunit TBC1D7 is stabilized by Akt phosphorylation-mediated 14-3-3 binding. Madigan JP, Hou F, Ye L, Hu J, Dong A, Tempel W, Yohe ME, Randazzo PA, Jenkins LMM, Gottesman MM, Tong Y. J Biol Chem. 2018 Oct 19;293(42):16142-16159. doi: 10.1074/jbc.RA118.003525. Epub 2018 Aug 24. PubMed |
| TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging. Xu D, Jin T, Zhu H, Chen H, Ofengeim D, Zou C, Mifflin L, Pan L, Amin P, Li W, Shan B, Naito MG, Meng H, Li Y, Pan H, Aron L, Adiconis X, Levin JZ, Yankner BA, Yuan J. Cell. 2018 Sep 6;174(6):1477-1491.e19. doi: 10.1016/j.cell.2018.07.041. Epub 2018 Aug 23. PubMed |
| Phenotypic Lentivirus Screens to Identify Antiviral Single Domain Antibodies. Schmidt FI. Methods Mol Biol. 2018;1836:139-158. doi: 10.1007/978-1-4939-8678-1_7. PubMed |
| G protein pathway suppressor 2 (GPS2) links inflammation and cholesterol efflux by controlling lipopolysaccharide-induced ATP-binding cassette transporter A1 expression in macrophages. Huang Z, Liang N, Damdimopoulos A, Fan R, Treuter E. FASEB J. 2019 Feb;33(2):1631-1643. doi: 10.1096/fj.201801123R. Epub 2018 Aug 28. PubMed |
| Human tryptophanyl-tRNA synthetase is an IFN-gamma-inducible entry factor for Enterovirus. Yeung ML, Jia L, Yip CCY, Chan JFW, Teng JLL, Chan KH, Cai JP, Zhang C, Zhang AJ, Wong WM, Kok KH, Lau SKP, Woo PCY, Lo JYC, Jin DY, Shih SR, Yuen KY. J Clin Invest. 2018 Nov 1;128(11):5163-5177. doi: 10.1172/JCI99411. Epub 2018 Oct 15. PubMed |
| Modulation of motor excitability by cortical optogenetic theta burst stimulation. Wu CW, Chiu WT, Hsieh TH, Hsieh CH, Chen JJ. PLoS One. 2018 Aug 30;13(8):e0203333. doi: 10.1371/journal.pone.0203333. eCollection 2018. PubMed |
| Cancer mutations and targeted drugs can disrupt dynamic signal encoding by the Ras-Erk pathway. Bugaj LJ, Sabnis AJ, Mitchell A, Garbarino JE, Toettcher JE, Bivona TG, Lim WA. Science. 2018 Aug 31;361(6405). pii: 361/6405/eaao3048. doi: 10.1126/science.aao3048. PubMed |
| Differentiation of Human Pluripotent Stem Cells to Megakaryocytes by Transcription Factor-Driven Forward Programming. Moreau T, Evans AL, Ghevaert CJG. Methods Mol Biol. 2018;1812:155-176. doi: 10.1007/978-1-4939-8585-2_10. PubMed |
| Discovery of a small molecule targeting autophagy via ATG4B inhibition and cell death of colorectal cancer cells in vitro and in vivo. Fu Y, Hong L, Xu J, Zhong G, Gu Q, Gu Q, Guan Y, Zheng X, Dai Q, Luo X, Liu C, Huang Z, Yin XM, Liu P, Li M. Autophagy. 2019 Feb;15(2):295-311. doi: 10.1080/15548627.2018.1517073. Epub 2018 Sep 20. PubMed |
| Inhibition of TRF2 accelerates telomere attrition and DNA damage in naive CD4 T cells during HCV infection. Nguyen LN, Zhao J, Cao D, Dang X, Wang L, Lian J, Zhang Y, Jia Z, Wu XY, Morrison Z, Xie Q, Ji Y, Zhang Z, El Gazzar M, Ning S, Moorman JP, Yao ZQ. Cell Death Dis. 2018 Sep 5;9(9):900. doi: 10.1038/s41419-018-0897-y. PubMed |
| Bradykinin B2 Receptor Contributes to Inflammatory Responses in Human Endothelial Cells by the Transactivation of the Fibroblast Growth Factor Receptor FGFR-1. Terzuoli E, Corti F, Nannelli G, Giachetti A, Donnini S, Ziche M. Int J Mol Sci. 2018 Sep 6;19(9). pii: ijms19092638. doi: 10.3390/ijms19092638. PubMed |
| Lentiviral vector expression of Klf4 enhances chondrogenesis and reduces hypertrophy in equine chondrocytes. Gurusinghe S, Bandara N, Hilbert B, Trope G, Wang L, Strappe P. Gene. 2019 Jan 5;680:9-19. doi: 10.1016/j.gene.2018.09.013. Epub 2018 Sep 8. PubMed |
| USP7 and USP47 deubiquitinases regulate NLRP3 inflammasome activation. Palazon-Riquelme P, Worboys JD, Green J, Valera A, Martin-Sanchez F, Pellegrini C, Brough D, Lopez-Castejon G. EMBO Rep. 2018 Oct;19(10). pii: embr.201744766. doi: 10.15252/embr.201744766. Epub 2018 Sep 11. PubMed |
| Elevated A20 promotes TNF-induced and RIPK1-dependent intestinal epithelial cell death. Garcia-Carbonell R, Wong J, Kim JY, Close LA, Boland BS, Wong TL, Harris PA, Ho SB, Das S, Ernst PB, Sasik R, Sandborn WJ, Bertin J, Gough PJ, Chang JT, Kelliher M, Boone D, Guma M, Karin M. Proc Natl Acad Sci U S A. 2018 Sep 25;115(39):E9192-E9200. doi: 10.1073/pnas.1810584115. Epub 2018 Sep 12. PubMed |
| Identification of Novel Subcellular Localization and Trafficking of HIV-1 Nef Variants from Reference Strains G (F1.93.HH8793) and H (BE.93.VI997). Van Nynatten LR, Johnson AL, Dirk BS, Pawlak EN, Jacob RA, Haeryfar SMM, Dikeakos JD. Viruses. 2018 Sep 13;10(9). pii: v10090493. doi: 10.3390/v10090493. PubMed |
| Unbiased Genetic Screen to Identify Factors Involved in X-Chromosome Inactivation Using a Pooled Bar-Coded shRNA Library. Moindrot B, Brockdorff N. Methods Mol Biol. 2018;1861:19-36. doi: 10.1007/978-1-4939-8766-5_2. PubMed |
| Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma. McBrayer SK, Mayers JR, DiNatale GJ, Shi DD, Khanal J, Chakraborty AA, Sarosiek KA, Briggs KJ, Robbins AK, Sewastianik T, Shareef SJ, Olenchock BA, Parker SJ, Tateishi K, Spinelli JB, Islam M, Haigis MC, Looper RE, Ligon KL, Bernstein BE, Carrasco RD, Cahill DP, Asara JM, Metallo CM, Yennawar NH, Vander Heiden MG, Kaelin WG Jr. Cell. 2018 Sep 20;175(1):101-116.e25. doi: 10.1016/j.cell.2018.08.038. Epub 2018 Sep 13. PubMed |
| Upregulation of liver kinase B1 predicts poor prognosis in hepatocellular carcinoma. Tan X, Liao Z, Liang H, Chen X, Zhang B, Chu L. Int J Oncol. 2018 Nov;53(5):1913-1926. doi: 10.3892/ijo.2018.4556. Epub 2018 Sep 7. PubMed |
| Host phosphatidic acid phosphatase lipin1 is rate limiting for functional hepatitis C virus replicase complex formation. Mingorance L, Castro V, Avila-Perez G, Calvo G, Rodriguez MJ, Carrascosa JL, Perez-Del-Pulgar S, Forns X, Gastaminza P. PLoS Pathog. 2018 Sep 18;14(9):e1007284. doi: 10.1371/journal.ppat.1007284. eCollection 2018 Sep. PubMed |
| Human Sox4 facilitates the development of CXCL13-producing helper T cells in inflammatory environments. Yoshitomi H, Kobayashi S, Miyagawa-Hayashino A, Okahata A, Doi K, Nishitani K, Murata K, Ito H, Tsuruyama T, Haga H, Matsuda S, Toguchida J. Nat Commun. 2018 Sep 19;9(1):3762. doi: 10.1038/s41467-018-06187-0. PubMed |
| Promyelocytic leukemia (PML) nuclear bodies (NBs) induce latent/quiescent HSV-1 genomes chromatinization through a PML NB/Histone H3.3/H3.3 Chaperone Axis. Cohen C, Corpet A, Roubille S, Maroui MA, Poccardi N, Rousseau A, Kleijwegt C, Binda O, Texier P, Sawtell N, Labetoulle M, Lomonte P. PLoS Pathog. 2018 Sep 20;14(9):e1007313. doi: 10.1371/journal.ppat.1007313. eCollection 2018 Sep. PubMed |
| Systematic genetic mapping of necroptosis identifies SLC39A7 as modulator of death receptor trafficking. Fauster A, Rebsamen M, Willmann KL, Cesar-Razquin A, Girardi E, Bigenzahn JW, Schischlik F, Scorzoni S, Bruckner M, Konecka J, Hormann K, Heinz LX, Boztug K, Superti-Furga G. Cell Death Differ. 2018 Sep 20. pii: 10.1038/s41418-018-0192-6. doi: 10.1038/s41418-018-0192-6. PubMed |
| The microRNA-23a cluster regulates the developmental HoxA cluster function during osteoblast differentiation. Godfrey TC, Wildman BJ, Beloti MM, Kemper AG, Ferraz EP, Roy B, Rehan M, Afreen LH, Kim E, Lengner CJ, Hassan Q. J Biol Chem. 2018 Nov 9;293(45):17646-17660. doi: 10.1074/jbc.RA118.003052. Epub 2018 Sep 21. PubMed |
| Discovering human diabetes-risk gene function with genetics and physiological assays. Peiris H, Park S, Louis S, Gu X, Lam JY, Asplund O, Ippolito GC, Bottino R, Groop L, Tucker H, Kim SK. Nat Commun. 2018 Sep 21;9(1):3855. doi: 10.1038/s41467-018-06249-3. PubMed |
| Interactive Repression of MYRF Self-Cleavage and Activity in Oligodendrocyte Differentiation by TMEM98 Protein. Huang H, Teng P, Du J, Meng J, Hu X, Tang T, Zhang Z, Qi YB, Qiu M. J Neurosci. 2018 Nov 14;38(46):9829-9839. doi: 10.1523/JNEUROSCI.0154-18.2018. Epub 2018 Sep 24. PubMed |
| Acute and rapid degradation of endogenous proteins by Trim-Away. Clift D, So C, McEwan WA, James LC, Schuh M. Nat Protoc. 2018 Oct;13(10):2149-2175. doi: 10.1038/s41596-018-0028-3. PubMed |
| Growth inhibition and chemo-radiosensitization of esophageal squamous cell carcinoma by survivin-shRNA lentivirus transfection. Zhou C, Zhang L, Xu P. Oncol Lett. 2018 Oct;16(4):4813-4820. doi: 10.3892/ol.2018.9280. Epub 2018 Aug 8. PubMed |
| RNA editing derived epitopes function as cancer antigens to elicit immune responses. Zhang M, Fritsche J, Roszik J, Williams LJ, Peng X, Chiu Y, Tsou CC, Hoffgaard F, Goldfinger V, Schoor O, Talukder A, Forget MA, Haymaker C, Bernatchez C, Han L, Tsang YH, Kong K, Xu X, Scott KL, Singh-Jasuja H, Lizee G, Liang H, Weinschenk T, Mills GB, Hwu P. Nat Commun. 2018 Sep 25;9(1):3919. doi: 10.1038/s41467-018-06405-9. PubMed |
| Repression of Noxa by Bmi1 contributes to deguelin-induced apoptosis in non-small cell lung cancer cells. Li W, Yu X, Xia Z, Yu X, Xie L, Ma X, Zhou H, Liu L, Wang J, Yang Y, Liu H. J Cell Mol Med. 2018 Dec;22(12):6213-6227. doi: 10.1111/jcmm.13908. Epub 2018 Sep 25. PubMed |
| BRCA1 Mutation-Specific Responses to 53BP1 Loss-Induced Homologous Recombination and PARP Inhibitor Resistance. Nacson J, Krais JJ, Bernhardy AJ, Clausen E, Feng W, Wang Y, Nicolas E, Cai KQ, Tricarico R, Hua X, DiMarcantonio D, Martinez E, Zong D, Handorf EA, Bellacosa A, Testa JR, Nussenzweig A, Gupta GP, Sykes SM, Johnson N. Cell Rep. 2018 Sep 25;24(13):3513-3527.e7. doi: 10.1016/j.celrep.2018.08.086. PubMed |
| Anoctamin 5/TMEM16E facilitates muscle precursor cell fusion. Whitlock JM, Yu K, Cui YY, Hartzell HC. J Gen Physiol. 2018 Nov 5;150(11):1498-1509. doi: 10.1085/jgp.201812097. Epub 2018 Sep 26. PubMed |
| Fc Gamma Receptor IIb Expressed in Hepatocytes Promotes Lipid Accumulation and Gluconeogenesis. Shu T, Song X, Cui X, Ge W, Gao R, Wang J. Int J Mol Sci. 2018 Sep 26;19(10). pii: ijms19102932. doi: 10.3390/ijms19102932. PubMed |
High Fidelity Cryopreservation and Recovery of Primary Rodent Cortical Neurons.
Parker SS, Moutal A, Cai S, Chandrasekaran S, Roman MR, Koshy AA, Khanna R, Zinsmaier KE, Mouneimne G.
eNeuro. 2018 Sep 27;5(5). pii: eN-MNT-0135-18. doi: 10.1523/ENEURO.0135-18.2018. eCollection 2018 Sep-Oct.
PubMed
Associated Plasmids |
Downregulation of SNCA Expression by Targeted Editing of DNA Methylation: A Potential Strategy for Precision Therapy in PD.
Kantor B, Tagliafierro L, Gu J, Zamora ME, Ilich E, Grenier C, Huang ZY, Murphy S, Chiba-Falek O.
Mol Ther. 2018 Nov 7;26(11):2638-2649. doi: 10.1016/j.ymthe.2018.08.019. Epub 2018 Aug 29.
PubMed
Associated Plasmids |
| RAB11FIP5 Expression and Altered Natural Killer Cell Function Are Associated with Induction of HIV Broadly Neutralizing Antibody Responses. Bradley T, Peppa D, Pedroza-Pacheco I, Li D, Cain DW, Henao R, Venkat V, Hora B, Chen Y, Vandergrift NA, Overman RG, Edwards RW, Woods CW, Tomaras GD, Ferrari G, Ginsburg GS, Connors M, Cohen MS, Moody MA, Borrow P, Haynes BF. Cell. 2018 Oct 4;175(2):387-399.e17. doi: 10.1016/j.cell.2018.08.064. Epub 2018 Sep 27. PubMed |
| Subversion of Systemic Glucose Metabolism as a Mechanism to Support the Growth of Leukemia Cells. Ye H, Adane B, Khan N, Alexeev E, Nusbacher N, Minhajuddin M, Stevens BM, Winters AC, Lin X, Ashton JM, Purev E, Xing L, Pollyea DA, Lozupone CA, Serkova NJ, Colgan SP, Jordan CT. Cancer Cell. 2018 Oct 8;34(4):659-673.e6. doi: 10.1016/j.ccell.2018.08.016. Epub 2018 Sep 27. PubMed |
| The DEAD-box RNA-binding protein DDX6 regulates parental RNA decay for cellular reprogramming to pluripotency. Kami D, Kitani T, Nakamura A, Wakui N, Mizutani R, Ohue M, Kametani F, Akimitsu N, Gojo S. PLoS One. 2018 Oct 1;13(10):e0203708. doi: 10.1371/journal.pone.0203708. eCollection 2018. PubMed |
| Analysis of chromatin accessibility uncovers TEAD1 as a regulator of migration in human glioblastoma. Tome-Garcia J, Erfani P, Nudelman G, Tsankov AM, Katsyv I, Tejero R, Bin Zhang, Walsh M, Friedel RH, Zaslavsky E, Tsankova NM. Nat Commun. 2018 Oct 1;9(1):4020. doi: 10.1038/s41467-018-06258-2. PubMed |
All-optical synaptic electrophysiology probes mechanism of ketamine-induced disinhibition.
Fan LZ, Nehme R, Adam Y, Jung ES, Wu H, Eggan K, Arnold DB, Cohen AE.
Nat Methods. 2018 Oct;15(10):823-831. doi: 10.1038/s41592-018-0142-8. Epub 2018 Oct 1.
PubMed
Associated Plasmids |
| IDH1 mutation correlates with a beneficial prognosis and suppresses tumor growth in IHCC. Wang J, Zhang ZG, Ding ZY, Dong W, Liang HF, Chu L, Zhang BX, Chen XP. J Surg Res. 2018 Nov;231:116-125. doi: 10.1016/j.jss.2018.04.056. Epub 2018 Jun 17. PubMed |
| Molecular architecture and regulation of BCL10-MALT1 filaments. Schlauderer F, Seeholzer T, Desfosses A, Gehring T, Strauss M, Hopfner KP, Gutsche I, Krappmann D, Lammens K. Nat Commun. 2018 Oct 2;9(1):4041. doi: 10.1038/s41467-018-06573-8. PubMed |
| Alpha ketoglutarate levels, regulated by p53 and OGDH, determine autophagy and cell fate/apoptosis in response to Nutlin-3a. Duan L, Perez RE, Maki CG. Cancer Biol Ther. 2019;20(3):252-260. doi: 10.1080/15384047.2018.1523858. Epub 2018 Oct 5. PubMed |
| Frequent PTEN loss and differential HER2/PI3K signaling pathway alterations in salivary duct carcinoma: Implications for targeted therapy. Saintigny P, Mitani Y, Pytynia KB, Ferrarotto R, Roberts DB, Weber RS, Kies MS, Maity SN, Lin SH, El-Naggar AK. Cancer. 2018 Sep 15;124(18):3693-3705. doi: 10.1002/cncr.31600. Epub 2018 Oct 5. PubMed |
AXL Is a Putative Tumor Suppressor and Dormancy Regulator in Prostate Cancer.
Axelrod HD, Valkenburg KC, Amend SR, Hicks JL, Parsana P, Torga G, DeMarzo AM, Pienta KJ.
Mol Cancer Res. 2019 Feb;17(2):356-369. doi: 10.1158/1541-7786.MCR-18-0718. Epub 2018 Oct 5.
PubMed
Associated Plasmids |
| Geometry-Dependent Arrhythmias in Electrically Excitable Tissues. McNamara HM, Dodson S, Huang YL, Miller EW, Sandstede B, Cohen AE. Cell Syst. 2018 Oct 24;7(4):359-370.e6. doi: 10.1016/j.cels.2018.08.013. Epub 2018 Oct 3. PubMed |
| Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers. Chiarella AM, Wang TA, Butler KV, Jin J, Hathaway NA. J Vis Exp. 2018 Sep 20;(139). doi: 10.3791/58222. PubMed |
MYC Interacts with the G9a Histone Methyltransferase to Drive Transcriptional Repression and Tumorigenesis.
Tu WB, Shiah YJ, Lourenco C, Mullen PJ, Dingar D, Redel C, Tamachi A, Ba-Alawi W, Aman A, Al-Awar R, Cescon DW, Haibe-Kains B, Arrowsmith CH, Raught B, Boutros PC, Penn LZ.
Cancer Cell. 2018 Oct 8;34(4):579-595.e8. doi: 10.1016/j.ccell.2018.09.001.
PubMed
Associated Plasmids |
| The Oncogenic Transcription Factor RUNX1/ETO Corrupts Cell Cycle Regulation to Drive Leukemic Transformation. Martinez-Soria N, McKenzie L, Draper J, Ptasinska A, Issa H, Potluri S, Blair HJ, Pickin A, Isa A, Chin PS, Tirtakusuma R, Coleman D, Nakjang S, Assi S, Forster V, Reza M, Law E, Berry P, Mueller D, Osborne C, Elder A, Bomken SN, Pal D, Allan JM, Veal GJ, Cockerill PN, Wichmann C, Vormoor J, Lacaud G, Bonifer C, Heidenreich O. Cancer Cell. 2018 Oct 8;34(4):626-642.e8. doi: 10.1016/j.ccell.2018.08.015. PubMed |
| A newly generated neuronal cell model of CLN7 disease reveals aberrant lysosome motility and impaired cell survival. von Kleist L, Ariunbat K, Braren I, Stauber T, Storch S, Danyukova T. Mol Genet Metab. 2019 Feb;126(2):196-205. doi: 10.1016/j.ymgme.2018.09.009. Epub 2018 Oct 1. PubMed |
| mTOR inhibitors lower an intrinsic barrier to virus infection mediated by IFITM3. Shi G, Ozog S, Torbett BE, Compton AA. Proc Natl Acad Sci U S A. 2018 Oct 23;115(43):E10069-E10078. doi: 10.1073/pnas.1811892115. Epub 2018 Oct 9. PubMed |
The interaction between ORF18 and ORF30 is required for late gene expression in Kaposi's sarcoma-associated herpesvirus.
Castaneda AF, Glaunsinger BA.
J Virol. 2018 Oct 10. pii: JVI.01488-18. doi: 10.1128/JVI.01488-18.
PubMed
Associated Plasmids |
| Increasing G9a automethylation sensitizes B acute lymphoblastic leukemia cells to glucocorticoid-induced death. Poulard C, Baulu E, Lee BH, Pufall MA, Stallcup MR. Cell Death Dis. 2018 Oct 10;9(10):1038. doi: 10.1038/s41419-018-1110-z. PubMed |
| GABAergic signaling linked to autophagy enhances host protection against intracellular bacterial infections. Kim JK, Kim YS, Lee HM, Jin HS, Neupane C, Kim S, Lee SH, Min JJ, Sasai M, Jeong JH, Choe SK, Kim JM, Yamamoto M, Choy HE, Park JB, Jo EK. Nat Commun. 2018 Oct 10;9(1):4184. doi: 10.1038/s41467-018-06487-5. PubMed |
| NRF2 transcriptionally activates the heat shock factor 1 promoter under oxidative stress and affects survival and migration potential of MCF7 cells. Paul S, Ghosh S, Mandal S, Sau S, Pal M. J Biol Chem. 2018 Dec 14;293(50):19303-19316. doi: 10.1074/jbc.RA118.003376. Epub 2018 Oct 11. PubMed |
| Lentiviral-based reporter constructs for profiling chondrogenic activity in primary equine cell populations. Martin-Pena A, Porter RM, Plumton G, McCarrel TM, Morton AJ, Guijarro MV, Ghivizzani SC, Sharma B, Palmer GD. Eur Cell Mater. 2018 Oct 12;36:156-170. doi: 10.22203/eCM.v036a12. PubMed |
| A metabolite-derived protein modification integrates glycolysis with KEAP1-NRF2 signalling. Bollong MJ, Lee G, Coukos JS, Yun H, Zambaldo C, Chang JW, Chin EN, Ahmad I, Chatterjee AK, Lairson LL, Schultz PG, Moellering RE. Nature. 2018 Oct;562(7728):600-604. doi: 10.1038/s41586-018-0622-0. Epub 2018 Oct 15. PubMed |
| Multi-stage bioengineering of a layered oesophagus with in vitro expanded muscle and epithelial adult progenitors. Urbani L, Camilli C, Phylactopoulos DE, Crowley C, Natarajan D, Scottoni F, Maghsoudlou P, McCann CJ, Pellegata AF, Urciuolo A, Deguchi K, Khalaf S, Aruta SF, Signorelli MC, Kiely D, Hannon E, Trevisan M, Wong RR, Baradez MO, Moulding D, Virasami A, Gjinovci A, Loukogeorgakis S, Mantero S, Thapar N, Sebire N, Eaton S, Lowdell M, Cossu G, Bonfanti P, De Coppi P. Nat Commun. 2018 Oct 16;9(1):4286. doi: 10.1038/s41467-018-06385-w. PubMed |
| Shear stress induces expression, intracellular reorganization and enhanced Notch activation potential of Jagged1. Driessen RCH, Stassen OMJA, Sjoqvist M, Suarez Rodriguez F, Grolleman J, Bouten CVC, Sahlgren CM. Integr Biol (Camb). 2018 Nov 12;10(11):719-726. doi: 10.1039/c8ib00036k. PubMed |
Farnesyl diphosphate synthase is important for the maintenance of glioblastoma stemness.
Kim HY, Kim DK, Bae SH, Gwak H, Jeon JH, Kim JK, Lee BI, You HJ, Shin DH, Kim YH, Kim SY, Han SS, Shim JK, Lee JH, Kang SG, Jang H.
Exp Mol Med. 2018 Oct 17;50(10):137. doi: 10.1038/s12276-018-0166-2.
PubMed
Associated Plasmids |
| Efficient in situ gene delivery via PEG diacrylate matrices. Shrimali P, Peter M, Singh A, Dalal N, Dakave S, Chiplunkar SV, Tayalia P. Biomater Sci. 2018 Nov 20;6(12):3241-3250. doi: 10.1039/c8bm00916c. PubMed |
| Improved dynamic monitoring of transcriptional activity during longitudinal analysis in the mouse brain. Heo H, Jo J, Jung JI, Han YM, Lee S, Kim SR, Kwon SH, Kim KN, Hwang BJ, Kee Y, Lee BD, Kang D, Her S. Biol Open. 2019 Jan 8;8(1). pii: bio.037168. doi: 10.1242/bio.037168. PubMed |
| A novel homozygous mutation in GAD1 gene described in a schizophrenic patient impairs activity and dimerization of GAD67 enzyme. Magri C, Giacopuzzi E, La Via L, Bonini D, Ravasio V, Elhussiny MEA, Orizio F, Gangemi F, Valsecchi P, Bresciani R, Barbon A, Vita A, Gennarelli M. Sci Rep. 2018 Oct 19;8(1):15470. doi: 10.1038/s41598-018-33924-8. PubMed |
| Dimerization of an aptamer generated from Ligand-guided selection (LIGS) yields a high affinity scaffold against B-cells. Batool S, Argyropoulos KV, Azad R, Okeoma P, Zumrut H, Bhandari S, Dekhang R, Mallikaratchy PR. Biochim Biophys Acta Gen Subj. 2019 Jan;1863(1):232-240. doi: 10.1016/j.bbagen.2018.10.006. Epub 2018 Oct 17. PubMed |
| A novel lysosome-to-mitochondria signaling pathway disrupted by amyloid-beta oligomers. Norambuena A, Wallrabe H, Cao R, Wang DB, Silva A, Svindrych Z, Periasamy A, Hu S, Tanzi RE, Kim DY, Bloom GS. EMBO J. 2018 Nov 15;37(22):e100241. doi: 10.15252/embj.2018100241. Epub 2018 Oct 22. PubMed |
| Monoubiquitination of ASXLs controls the deubiquitinase activity of the tumor suppressor BAP1. Daou S, Barbour H, Ahmed O, Masclef L, Baril C, Sen Nkwe N, Tchelougou D, Uriarte M, Bonneil E, Ceccarelli D, Mashtalir N, Tanji M, Masson JY, Thibault P, Sicheri F, Yang H, Carbone M, Therrien M, Affar EB. Nat Commun. 2018 Oct 22;9(1):4385. doi: 10.1038/s41467-018-06854-2. PubMed |
| Increased invasive phenotype of CSF-1R expression in glioma cells via the ERK1/2 signaling pathway. Sun L, Liang H, Yu W, Jin X. Cancer Gene Ther. 2018 Oct 26. pii: 10.1038/s41417-018-0053-y. doi: 10.1038/s41417-018-0053-y. PubMed |
| Delivery of shRNA via lentivirus in human pseudoislets provides a model to test dynamic regulation of insulin secretion and gene function in human islets. Harata M, Liu S, Promes JA, Burand AJ, Ankrum JA, Imai Y. Physiol Rep. 2018 Oct;6(20):e13907. doi: 10.14814/phy2.13907. PubMed |
Cells Lacking the RB1 Tumor Suppressor Gene Are Hyperdependent on Aurora B Kinase for Survival.
Oser MG, Fonseca R, Chakraborty AA, Brough R, Spektor A, Jennings RB, Flaifel A, Novak JS, Gulati A, Buss E, Younger ST, McBrayer SK, Cowley GS, Bonal DM, Nguyen QD, Brulle-Soumare L, Taylor P, Cairo S, Ryan CJ, Pease EJ, Maratea K, Travers J, Root DE, Signoretti S, Pellman D, Ashton S, Lord CJ, Barry ST, Kaelin WG Jr.
Cancer Discov. 2019 Feb;9(2):230-247. doi: 10.1158/2159-8290.CD-18-0389. Epub 2018 Oct 29.
PubMed
Associated Plasmids |
| Reversal of ApoE4-induced recycling block as a novel prevention approach for Alzheimer's disease. Xian X, Pohlkamp T, Durakoglugil MS, Wong CH, Beck JK, Lane-Donovan C, Plattner F, Herz J. Elife. 2018 Oct 30;7. pii: 40048. doi: 10.7554/eLife.40048. PubMed |
| Foxm1 is a critical driver of TGF-beta-induced EndMT in endothelial cells through Smad2/3 and binds to the Snail promoter. Song S, Zhang R, Cao W, Fang G, Yu Y, Wan Y, Wang C, Li Y, Wang Q. J Cell Physiol. 2019 Jun;234(6):9052-9064. doi: 10.1002/jcp.27583. Epub 2018 Oct 30. PubMed |
| Parkin targets NOD2 to regulate astrocyte endoplasmic reticulum stress and inflammation. Singh K, Han K, Tilve S, Wu K, Geller HM, Sack MN. Glia. 2018 Nov;66(11):2427-2437. doi: 10.1002/glia.23482. Epub 2018 Oct 30. PubMed |
| Loss of endogenous RNF43 function enhances proliferation and tumour growth of intestinal and gastric cells. Neumeyer V, Grandl M, Dietl A, Brutau-Abia A, Allgauer M, Kalali B, Zhang Y, Pan KF, Steiger K, Vieth M, Anton M, Mejias-Luque R, Gerhard M. Carcinogenesis. 2018 Oct 31. pii: 5149556. doi: 10.1093/carcin/bgy152. PubMed |
| Autophagy inhibition as a potential future targeted therapy for ETV6-RUNX1-driven B-cell precursor acute lymphoblastic leukemia. Polak R, Bierings MB, van der Leije CS, Sanders MA, Roovers O, Marchante JRM, Boer JM, Cornelissen JJ, Pieters R, den Boer ML, Buitenhuis M. Haematologica. 2019 Apr;104(4):738-748. doi: 10.3324/haematol.2018.193631. Epub 2018 Oct 31. PubMed |
| p53 mutants cooperate with HIF-1 in transcriptional regulation of extracellular matrix components to promote tumor progression. Amelio I, Mancini M, Petrova V, Cairns RA, Vikhreva P, Nicolai S, Marini A, Antonov AA, Le Quesne J, Baena Acevedo JD, Dudek K, Sozzi G, Pastorino U, Knight RA, Mak TW, Melino G. Proc Natl Acad Sci U S A. 2018 Nov 13;115(46):E10869-E10878. doi: 10.1073/pnas.1808314115. Epub 2018 Oct 31. PubMed |
| Redox regulation of EGFR steers migration of hypoxic mammary cells towards oxygen. Deygas M, Gadet R, Gillet G, Rimokh R, Gonzalo P, Mikaelian I. Nat Commun. 2018 Oct 31;9(1):4545. doi: 10.1038/s41467-018-06988-3. PubMed |
| Novel flavagline-like compounds with potent Fli-1 inhibitory activity suppress diverse types of leukemia. Song J, Yuan C, Yang J, Liu T, Yao Y, Xiao X, Gajendran B, Xu D, Li YJ, Wang C, Liu W, Wen M, Spaner D, Filmus J, Zacksenhaus E, Zhang Y, Hao X, Ben-David Y. FEBS J. 2018 Dec;285(24):4631-4645. doi: 10.1111/febs.14690. Epub 2018 Nov 20. PubMed |
| Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma. Sade-Feldman M, Yizhak K, Bjorgaard SL, Ray JP, de Boer CG, Jenkins RW, Lieb DJ, Chen JH, Frederick DT, Barzily-Rokni M, Freeman SS, Reuben A, Hoover PJ, Villani AC, Ivanova E, Portell A, Lizotte PH, Aref AR, Eliane JP, Hammond MR, Vitzthum H, Blackmon SM, Li B, Gopalakrishnan V, Reddy SM, Cooper ZA, Paweletz CP, Barbie DA, Stemmer-Rachamimov A, Flaherty KT, Wargo JA, Boland GM, Sullivan RJ, Getz G, Hacohen N. Cell. 2018 Nov 1;175(4):998-1013.e20. doi: 10.1016/j.cell.2018.10.038. PubMed |
| Trichomonas vaginalis Induces NLRP3 Inflammasome Activation and Pyroptotic Cell Death in Human Macrophages. Riestra AM, Valderrama JA, Patras KA, Booth SD, Quek XY, Tsai CM, Nizet V. J Innate Immun. 2019;11(1):86-98. doi: 10.1159/000493585. Epub 2018 Nov 2. PubMed |
| Polarity Acquisition in Cortical Neurons Is Driven by Synergistic Action of Sox9-Regulated Wwp1 and Wwp2 E3 Ubiquitin Ligases and Intronic miR-140. Ambrozkiewicz MC, Schwark M, Kishimoto-Suga M, Borisova E, Hori K, Salazar-Lazaro A, Rusanova A, Altas B, Piepkorn L, Bessa P, Schaub T, Zhang X, Rabe T, Ripamonti S, Rosario M, Akiyama H, Jahn O, Kobayashi T, Hoshino M, Tarabykin V, Kawabe H. Neuron. 2018 Dec 5;100(5):1097-1115.e15. doi: 10.1016/j.neuron.2018.10.008. Epub 2018 Nov 1. PubMed |
| Tumor-on-a-chip platform to investigate progression and drug sensitivity in cell lines and patient-derived organoids. Shirure VS, Bi Y, Curtis MB, Lezia A, Goedegebuure MM, Goedegebuure SP, Aft R, Fields RC, George SC. Lab Chip. 2018 Dec 7;18(23):3687-3702. doi: 10.1039/c8lc00596f. Epub 2018 Nov 5. PubMed |
| Poly(ADP-ribose) polymerase 1 is necessary for coactivating hypoxia-inducible factor-1-dependent gene expression by Epstein-Barr virus latent membrane protein 1. Hulse M, Caruso LB, Madzo J, Tan Y, Johnson S, Tempera I. PLoS Pathog. 2018 Nov 5;14(11):e1007394. doi: 10.1371/journal.ppat.1007394. eCollection 2018 Nov. PubMed |
| HEXIM1-Tat chimera inhibits HIV-1 replication. Leoz M, Kukanja P, Luo Z, Huang F, Cary DC, Peterlin BM, Fujinaga K. PLoS Pathog. 2018 Nov 5;14(11):e1007402. doi: 10.1371/journal.ppat.1007402. eCollection 2018 Nov. PubMed |
| A single-cell survey of the human first-trimester placenta and decidua. Suryawanshi H, Morozov P, Straus A, Sahasrabudhe N, Max KEA, Garzia A, Kustagi M, Tuschl T, Williams Z. Sci Adv. 2018 Oct 31;4(10):eaau4788. doi: 10.1126/sciadv.aau4788. eCollection 2018 Oct. PubMed |
| Cell-to-Cell Transmission Is the Main Mechanism Supporting Bovine Viral Diarrhea Virus Spread in Cell Culture. Merwaiss F, Czibener C, Alvarez DE. J Virol. 2019 Jan 17;93(3). pii: JVI.01776-18. doi: 10.1128/JVI.01776-18. Print 2019 Feb 1. PubMed |
| Rab22A recruits BLOC-1 and BLOC-2 to promote the biogenesis of recycling endosomes. Shakya S, Sharma P, Bhatt AM, Jani RA, Delevoye C, Setty SR. EMBO Rep. 2018 Dec;19(12). pii: embr.201845918. doi: 10.15252/embr.201845918. Epub 2018 Nov 7. PubMed |
| A Human Gonadal Cell Model From Induced Pluripotent Stem Cells. Rodriguez Gutierrez D, Eid W, Biason-Lauber A. Front Genet. 2018 Oct 24;9:498. doi: 10.3389/fgene.2018.00498. eCollection 2018. PubMed |
| TRIM59 promotes breast cancer motility by suppressing p62-selective autophagic degradation of PDCD10. Tan P, Ye Y, He L, Xie J, Jing J, Ma G, Pan H, Han L, Han W, Zhou Y. PLoS Biol. 2018 Nov 8;16(11):e3000051. doi: 10.1371/journal.pbio.3000051. eCollection 2018 Nov. PubMed |
| A Whole-genome CRISPR Screen Identifies a Role of MSH2 in Cisplatin-mediated Cell Death in Muscle-invasive Bladder Cancer. Goodspeed A, Jean A, Costello JC. Eur Urol. 2019 Feb;75(2):242-250. doi: 10.1016/j.eururo.2018.10.040. Epub 2018 Nov 7. PubMed |
| Effective Glucose Uptake by Human Astrocytes Requires Its Sequestration in the Endoplasmic Reticulum by Glucose-6-Phosphatase-beta. Muller MS, Fouyssac M, Taylor CW. Curr Biol. 2018 Nov 5;28(21):3481-3486.e4. doi: 10.1016/j.cub.2018.08.060. Epub 2018 Oct 25. PubMed |
| LAT2 regulates glutamine-dependent mTOR activation to promote glycolysis and chemoresistance in pancreatic cancer. Feng M, Xiong G, Cao Z, Yang G, Zheng S, Qiu J, You L, Zheng L, Zhang T, Zhao Y. J Exp Clin Cancer Res. 2018 Nov 12;37(1):274. doi: 10.1186/s13046-018-0947-4. PubMed |
| Predicting Novel Therapies and Targets: Regulation of Notch3 by the Bromodomain Protein BRD4. Villar-Prados A, Wu SY, Court KA, Ma S, LaFargue C, Chowdhury MA, Engelhardt MI, Ivan C, Ram PT, Wang Y, Baggerly K, Rodriguez-Aguayo C, Lopez-Berestein G, Ming-Yang S, Maloney DJ, Yoshioka M, Strovel JW, Roszik J, Sood AK. Mol Cancer Ther. 2019 Feb;18(2):421-436. doi: 10.1158/1535-7163.MCT-18-0365. Epub 2018 Nov 12. PubMed |
| Brain injury induces HIF-1alpha-dependent transcriptional activation of LRRK2 that exacerbates brain damage. Bae YH, Joo H, Bae J, Hyeon SJ, Her S, Ko E, Choi HG, Ryu H, Hur EM, Bu Y, Lee BD. Cell Death Dis. 2018 Nov 12;9(11):1125. doi: 10.1038/s41419-018-1180-y. PubMed |
| Centrosomal protein TRIM43 restricts herpesvirus infection by regulating nuclear lamina integrity. Full F, van Gent M, Sparrer KMJ, Chiang C, Zurenski MA, Scherer M, Brockmeyer NH, Heinzerling L, Sturzl M, Korn K, Stamminger T, Ensser A, Gack MU. Nat Microbiol. 2019 Jan;4(1):164-176. doi: 10.1038/s41564-018-0285-5. Epub 2018 Nov 12. PubMed |
| The Osteogenic Niche Is a Calcium Reservoir of Bone Micrometastases and Confers Unexpected Therapeutic Vulnerability. Wang H, Tian L, Liu J, Goldstein A, Bado I, Zhang W, Arenkiel BR, Li Z, Yang M, Du S, Zhao H, Rowley DR, Wong STC, Gugala Z, Zhang XH. Cancer Cell. 2018 Nov 12;34(5):823-839.e7. doi: 10.1016/j.ccell.2018.10.002. PubMed |
| Detailed Characterization of Early HIV-1 Replication Dynamics in Primary Human Macrophages. Bejarano DA, Puertas MC, Borner K, Martinez-Picado J, Muller B, Krausslich HG. Viruses. 2018 Nov 10;10(11). pii: v10110620. doi: 10.3390/v10110620. PubMed |
| Long noncoding RNA Fer1like family member 4 suppresses hepatocellular carcinoma cell proliferation by regulating PTEN in vitro and in vivo. Sun X, Zheng G, Li C, Liu C. Mol Med Rep. 2019 Jan;19(1):685-692. doi: 10.3892/mmr.2018.9629. Epub 2018 Nov 7. PubMed |
| Sigma-2 Receptor/TMEM97 and PGRMC-1 Increase the Rate of Internalization of LDL by LDL Receptor through the Formation of a Ternary Complex. Riad A, Zeng C, Weng CC, Winters H, Xu K, Makvandi M, Metz T, Carlin S, Mach RH. Sci Rep. 2018 Nov 15;8(1):16845. doi: 10.1038/s41598-018-35430-3. PubMed |
| HDAC6 differentially regulates autophagy in stem-like versus differentiated cancer cells. Sharif T, Martell E, Dai C, Ghassemi-Rad MS, Hanes MR, Murphy PJ, Margam NN, Parmar HB, Giacomantonio CA, Duncan R, Lee PWK, Gujar S. Autophagy. 2019 Apr;15(4):686-706. doi: 10.1080/15548627.2018.1548547. Epub 2018 Dec 4. PubMed |
| MiRNA-218 regulates osteoclast differentiation and inflammation response in periodontitis rats through Mmp9. Guo J, Zeng X, Miao J, Liu C, Wei F, Liu D, Zheng Z, Ting K, Wang C, Liu Y. Cell Microbiol. 2019 Apr;21(4):e12979. doi: 10.1111/cmi.12979. Epub 2019 Jan 15. PubMed |
Mapping Cellular Reprogramming via Pooled Overexpression Screens with Paired Fitness and Single-Cell RNA-Sequencing Readout.
Parekh U, Wu Y, Zhao D, Worlikar A, Shah N, Zhang K, Mali P.
Cell Syst. 2018 Nov 12. pii: S2405-4712(18)30433-2. doi: 10.1016/j.cels.2018.10.008.
PubMed
Associated Plasmids |
| Genome-wide CRISPR Screens in Primary Human T Cells Reveal Key Regulators of Immune Function. Shifrut E, Carnevale J, Tobin V, Roth TL, Woo JM, Bui CT, Li PJ, Diolaiti ME, Ashworth A, Marson A. Cell. 2018 Dec 13;175(7):1958-1971.e15. doi: 10.1016/j.cell.2018.10.024. Epub 2018 Nov 15. PubMed |
| Oncogenic Amplification of Zygotic Dux Factors in Regenerating p53-Deficient Muscle Stem Cells Defines a Molecular Cancer Subtype. Preussner J, Zhong J, Sreenivasan K, Gunther S, Engleitner T, Kunne C, Glatzel M, Rad R, Looso M, Braun T, Kim J. Cell Stem Cell. 2018 Dec 6;23(6):794-805.e4. doi: 10.1016/j.stem.2018.10.011. Epub 2018 Nov 15. PubMed |
| Measurement of Force-Sensitive Protein Dynamics in Living Cells Using a Combination of Fluorescent Techniques. Rothenberg KE, Puranam I, Hoffman BD. J Vis Exp. 2018 Nov 2;(141). doi: 10.3791/58619. PubMed |
Lentiviral transduction of mammalian cells for fast, scalable and high-level production of soluble and membrane proteins.
Elegheert J, Behiels E, Bishop B, Scott S, Woolley RE, Griffiths SC, Byrne EFX, Chang VT, Stuart DI, Jones EY, Siebold C, Aricescu AR.
Nat Protoc. 2018 Nov 19. pii: 10.1038/s41596-018-0075-9. doi: 10.1038/s41596-018-0075-9.
PubMed
Associated Plasmids |
| Peptide-based PET quantifies target engagement of PD-L1 therapeutics. Kumar D, Lisok A, Dahmane E, McCoy M, Shelake S, Chatterjee S, Allaj V, Sysa-Shah P, Wharram B, Lesniak WG, Tully E, Gabrielson E, Jaffee EM, Poirier JT, Rudin CM, Gobburu JV, Pomper MG, Nimmagadda S. J Clin Invest. 2019 Feb 1;129(2):616-630. doi: 10.1172/JCI122216. Epub 2019 Jan 7. PubMed |
| Oxidative Stress in Cells with Extra Centrosomes Drives Non-Cell-Autonomous Invasion. Arnandis T, Monteiro P, Adams SD, Bridgeman VL, Rajeeve V, Gadaleta E, Marzec J, Chelala C, Malanchi I, Cutillas PR, Godinho SA. Dev Cell. 2018 Nov 19;47(4):409-424.e9. doi: 10.1016/j.devcel.2018.10.026. PubMed |
| Vasoinhibin comprises a three-helix bundle and its antiangiogenic domain is located within the first 79 residues. Robles JP, Zamora M, Velasco-Bolom JL, Tovar M, Garduno-Juarez R, Bertsch T, Martinez de la Escalera G, Triebel J, Clapp C. Sci Rep. 2018 Nov 20;8(1):17111. doi: 10.1038/s41598-018-35383-7. PubMed |
| Vascularization and Engraftment of Transplanted Human Cerebral Organoids in Mouse Cortex. Daviaud N, Friedel RH, Zou H. eNeuro. 2018 Nov 20;5(6). pii: eN-NWR-0219-18. doi: 10.1523/ENEURO.0219-18.2018. eCollection 2018 Nov-Dec. PubMed |
| Activation of miR-21-Regulated Pathways in Immune Aging Selects against Signatures Characteristic of Memory T Cells. Kim C, Hu B, Jadhav RR, Jin J, Zhang H, Cavanagh MM, Akondy RS, Ahmed R, Weyand CM, Goronzy JJ. Cell Rep. 2018 Nov 20;25(8):2148-2162.e5. doi: 10.1016/j.celrep.2018.10.074. PubMed |
| Plasminogen Activator Inhibitor-1 Promotes the Recruitment and Polarization of Macrophages in Cancer. Kubala MH, Punj V, Placencio-Hickok VR, Fang H, Fernandez GE, Sposto R, DeClerck YA. Cell Rep. 2018 Nov 20;25(8):2177-2191.e7. doi: 10.1016/j.celrep.2018.10.082. PubMed |
| Transmembrane Protease TMPRSS11B Promotes Lung Cancer Growth by Enhancing Lactate Export and Glycolytic Metabolism. Updegraff BL, Zhou X, Guo Y, Padanad MS, Chen PH, Yang C, Sudderth J, Rodriguez-Tirado C, Girard L, Minna JD, Mishra P, DeBerardinis RJ, O'Donnell KA. Cell Rep. 2018 Nov 20;25(8):2223-2233.e6. doi: 10.1016/j.celrep.2018.10.100. PubMed |
| Repair pathway for PARP-1 DNA-protein crosslinks. Prasad R, Horton JK, Dai DP, Wilson SH. DNA Repair (Amst). 2019 Jan;73:71-77. doi: 10.1016/j.dnarep.2018.11.004. Epub 2018 Nov 12. PubMed |
| Hyperactivation of ERK by multiple mechanisms is toxic to RTK-RAS mutation-driven lung adenocarcinoma cells. Unni AM, Harbourne B, Oh MH, Wild S, Ferrarone JR, Lockwood WW, Varmus H. Elife. 2018 Nov 26;7. pii: 33718. doi: 10.7554/eLife.33718. PubMed |
| LncRNA Meg3 protects endothelial function by regulating the DNA damage response. Shihabudeen Haider Ali MS, Cheng X, Moran M, Haemmig S, Naldrett MJ, Alvarez S, Feinberg MW, Sun X. Nucleic Acids Res. 2018 Nov 22. pii: 5198489. doi: 10.1093/nar/gky1190. PubMed |
| Predicting the mutations generated by repair of Cas9-induced double-strand breaks. Allen F, Crepaldi L, Alsinet C, Strong AJ, Kleshchevnikov V, De Angeli P, Palenikova P, Khodak A, Kiselev V, Kosicki M, Bassett AR, Harding H, Galanty Y, Munoz-Martinez F, Metzakopian E, Jackson SP, Parts L. Nat Biotechnol. 2018 Nov 27. pii: nbt.4317. doi: 10.1038/nbt.4317. PubMed |
| PUFA-Plasmalogens Attenuate the LPS-Induced Nitric Oxide Production by Inhibiting the NF-kB, p38 MAPK and JNK Pathways in Microglial Cells. Youssef M, Ibrahim A, Akashi K, Hossain MS. Neuroscience. 2019 Jan 15;397:18-30. doi: 10.1016/j.neuroscience.2018.11.030. Epub 2018 Nov 26. PubMed |
| Cis interaction between sialylated FcgammaRIIA and the alphaI-domain of Mac-1 limits antibody-mediated neutrophil recruitment. Saggu G, Okubo K, Chen Y, Vattepu R, Tsuboi N, Rosetti F, Cullere X, Washburn N, Tahir S, Rosado AM, Holland SM, Anthony RM, Sen M, Zhu C, Mayadas TN. Nat Commun. 2018 Nov 29;9(1):5058. doi: 10.1038/s41467-018-07506-1. PubMed |
| A Combination of Visudyne and a Lipid-anchored Liposomal Formulation of Benzoporphyrin Derivative Enhances Photodynamic Therapy Efficacy in a 3D Model for Ovarian Cancer. Rizvi I, Nath S, Obaid G, Ruhi MK, Moore K, Bano S, Kessel D, Hasan T. Photochem Photobiol. 2019 Jan;95(1):419-429. doi: 10.1111/php.13066. Epub 2019 Jan 7. PubMed |
| Inflammatory Cytokine TNFalpha Promotes the Long-Term Expansion of Primary Hepatocytes in 3D Culture. Peng WC, Logan CY, Fish M, Anbarchian T, Aguisanda F, Alvarez-Varela A, Wu P, Jin Y, Zhu J, Li B, Grompe M, Wang B, Nusse R. Cell. 2018 Nov 29;175(6):1607-1619.e15. doi: 10.1016/j.cell.2018.11.012. PubMed |
| Protein Phosphatase 1 Regulatory Subunit SDS22 Inhibits Breast Cancer Cell Tumorigenesis by Functioning as a Negative Regulator of the AKT Signaling Pathway. Paul D, Bargale AB, Rapole S, Shetty PK, Santra MK. Neoplasia. 2019 Jan;21(1):30-40. doi: 10.1016/j.neo.2018.10.009. Epub 2018 Nov 27. PubMed |
| Enhancer Architecture and Essential Core Regulatory Circuitry of Chronic Lymphocytic Leukemia. Ott CJ, Federation AJ, Schwartz LS, Kasar S, Klitgaard JL, Lenci R, Li Q, Lawlor M, Fernandes SM, Souza A, Polaski D, Gadi D, Freedman ML, Brown JR, Bradner JE. Cancer Cell. 2018 Dec 10;34(6):982-995.e7. doi: 10.1016/j.ccell.2018.11.001. Epub 2018 Nov 29. PubMed |
| Fungal ligands released by innate immune effectors promote inflammasome activation during Aspergillus fumigatus infection. Briard B, Karki R, Malireddi RKS, Bhattacharya A, Place DE, Mavuluri J, Peters JL, Vogel P, Yamamoto M, Kanneganti TD. Nat Microbiol. 2019 Feb;4(2):316-327. doi: 10.1038/s41564-018-0298-0. Epub 2018 Dec 3. PubMed |
| Honey bee Royalactin unlocks conserved pluripotency pathway in mammals. Wan DC, Morgan SL, Spencley AL, Mariano N, Chang EY, Shankar G, Luo Y, Li TH, Huh D, Huynh SK, Garcia JM, Dovey CM, Lumb J, Liu L, Brown KV, Bermudez A, Luong R, Zeng H, Mascetti VL, Pitteri SJ, Wang J, Tu H, Quarta M, Sebastiano V, Nusse R, Rando TA, Carette JE, Bazan JF, Wang KC. Nat Commun. 2018 Dec 4;9(1):5078. doi: 10.1038/s41467-018-06256-4. PubMed |
| BCL10-CARD11 Fusion Mimics an Active CARD11 Seed That Triggers Constitutive BCL10 Oligomerization and Lymphocyte Activation. Seeholzer T, Kurz S, Schlauderer F, Woods S, Gehring T, Widmann S, Lammens K, Krappmann D. Front Immunol. 2018 Nov 20;9:2695. doi: 10.3389/fimmu.2018.02695. eCollection 2018. PubMed |
| Ex vivo Culture and Lentiviral Transduction of Benign Prostatic Hyperplasia (BPH) Samples. McClurg UL, McCracken SR, Butler L, Riabowol KT, Binda O. Bio Protoc. 2018 Nov 5;8(21). doi: 10.21769/BioProtoc.3075. PubMed |
| The HDAC-Associated Sin3B Protein Represses DREAM Complex Targets and Cooperates with APC/C to Promote Quiescence. Bainor AJ, Saini S, Calderon A, Casado-Polanco R, Giner-Ramirez B, Moncada C, Cantor DJ, Ernlund A, Litovchick L, David G. Cell Rep. 2018 Dec 4;25(10):2797-2807.e8. doi: 10.1016/j.celrep.2018.11.024. PubMed |
| Exome Sequencing of Drug-Resistant Clones for Target Identification. Han T, Nijhawan D. Methods Mol Biol. 2019;1888:175-187. doi: 10.1007/978-1-4939-8891-4_10. PubMed |
| A virus-packageable CRISPR screen identifies host factors mediating interferon inhibition of HIV. OhAinle M, Helms L, Vermeire J, Roesch F, Humes D, Basom R, Delrow JJ, Overbaugh J, Emerman M. Elife. 2018 Dec 6;7. pii: 39823. doi: 10.7554/eLife.39823. PubMed |
| Whole genome variant association across 100 dogs identifies a frame shift mutation in DISHEVELLED 2 which contributes to Robinow-like syndrome in Bulldogs and related screw tail dog breeds. Mansour TA, Lucot K, Konopelski SE, Dickinson PJ, Sturges BK, Vernau KL, Choi S, Stern JA, Thomasy SM, Doring S, Verstraete FJM, Johnson EG, York D, Rebhun RB, Ho HH, Brown CT, Bannasch DL. PLoS Genet. 2018 Dec 6;14(12):e1007850. doi: 10.1371/journal.pgen.1007850. eCollection 2018 Dec. PubMed |
| Interferons Transcriptionally Up-Regulate MLKL Expression in Cancer Cells. Knuth AK, Rosler S, Schenk B, Kowald L, van Wijk SJL, Fulda S. Neoplasia. 2019 Jan;21(1):74-81. doi: 10.1016/j.neo.2018.11.002. Epub 2018 Dec 3. PubMed |
| Inhibition of Inflammatory Signaling in Tet2 Mutant Preleukemic Cells Mitigates Stress-Induced Abnormalities and Clonal Hematopoiesis. Cai Z, Kotzin JJ, Ramdas B, Chen S, Nelanuthala S, Palam LR, Pandey R, Mali RS, Liu Y, Kelley MR, Sandusky G, Mohseni M, Williams A, Henao-Mejia J, Kapur R. Cell Stem Cell. 2018 Dec 6;23(6):833-849.e5. doi: 10.1016/j.stem.2018.10.013. PubMed |
| Unveiling the Role of the Most Impactful Cardiovascular Risk Locus through Haplotype Editing. Lo Sardo V, Chubukov P, Ferguson W, Kumar A, Teng EL, Duran M, Zhang L, Cost G, Engler AJ, Urnov F, Topol EJ, Torkamani A, Baldwin KK. Cell. 2018 Dec 13;175(7):1796-1810.e20. doi: 10.1016/j.cell.2018.11.014. Epub 2018 Dec 6. PubMed |
Engineering Epigenetic Regulation Using Synthetic Read-Write Modules.
Park M, Patel N, Keung AJ, Khalil AS.
Cell. 2019 Jan 10;176(1-2):227-238.e20. doi: 10.1016/j.cell.2018.11.002. Epub 2018 Dec 6.
PubMed
Associated Plasmids |
| Inhibition of CPAP-tubulin interaction prevents proliferation of centrosome-amplified cancer cells. Mariappan A, Soni K, Schorpp K, Zhao F, Minakar A, Zheng X, Mandad S, Macheleidt I, Ramani A, Kubelka T, Dawidowski M, Golfmann K, Wason A, Yang C, Simons J, Schmalz HG, Hyman AA, Aneja R, Ullrich R, Urlaub H, Odenthal M, Buttner R, Li H, Sattler M, Hadian K, Gopalakrishnan J. EMBO J. 2019 Jan 15;38(2). pii: embj.201899876. doi: 10.15252/embj.201899876. Epub 2018 Dec 10. PubMed |
| Binding of HMGN proteins to cell specific enhancers stabilizes cell identity. He B, Deng T, Zhu I, Furusawa T, Zhang S, Tang W, Postnikov Y, Ambs S, Li CC, Livak F, Landsman D, Bustin M. Nat Commun. 2018 Dec 7;9(1):5240. doi: 10.1038/s41467-018-07687-9. PubMed |
| Human nuclear RNAi-defective 2 (NRDE2) is an essential RNA splicing factor. Jiao AL, Perales R, Umbreit NT, Haswell JR, Piper ME, Adams BD, Pellman D, Kennedy S, Slack FJ. RNA. 2019 Mar;25(3):352-363. doi: 10.1261/rna.069773.118. Epub 2018 Dec 11. PubMed |
| Cancer Suicide Gene Therapy with TK.007. Hossain JA, Riecken K, Miletic H, Fehse B. Methods Mol Biol. 2019;1895:11-26. doi: 10.1007/978-1-4939-8922-5_2. PubMed |
| KLF4, A Gene Regulating Prostate Stem Cell Homeostasis, Is a Barrier to Malignant Progression and Predictor of Good Prognosis in Prostate Cancer. Xiong X, Schober M, Tassone E, Khodadadi-Jamayran A, Sastre-Perona A, Zhou H, Tsirigos A, Shen S, Chang M, Melamed J, Ossowski L, Wilson EL. Cell Rep. 2018 Dec 11;25(11):3006-3020.e7. doi: 10.1016/j.celrep.2018.11.065. PubMed |
| Insulin-Like Growth Factor 2 Receptor Expression Is Promoted by Human Herpesvirus 8-Encoded Interleukin-6 and Contributes to Viral Latency and Productive Replication. Li Q, Chen D, Xiang Q, Nicholas J. J Virol. 2019 Feb 19;93(5). pii: JVI.02026-18. doi: 10.1128/JVI.02026-18. Print 2019 Mar 1. PubMed |
| Mutagenesis Screens for Prostate Cancer Using Replication-Incompetent Lentiviral Vectors. Trobridge GD. Methods Mol Biol. 2019;1907:103-114. doi: 10.1007/978-1-4939-8967-6_8. PubMed |
| A20 and ABIN1 Suppression of a Keratinocyte Inflammatory Program with a Shared Single-Cell Expression Signature in Diverse Human Rashes. Harirchian P, Lee J, Hilz S, Sedgewick AJ, Perez White BE, Kesling MJ, Mully T, Golovato J, Gray M, Mauro TM, Purdom E, Kim EA, Sbitany H, Bhutani T, Vaske CJ, Benz SC, Cho RJ, Cheng JB. J Invest Dermatol. 2018 Dec 10. pii: S0022-202X(18)32924-5. doi: 10.1016/j.jid.2018.10.046. PubMed |
| Calretinin Functions in Malignant Mesothelioma Cells Cannot Be Replaced by the Closely Related Ca(2+)-Binding Proteins Calbindin-D28k and Parvalbumin. Worthmuller J, Oberson A, Salicio V, Blum W, Schwaller B. Int J Mol Sci. 2018 Dec 12;19(12). pii: ijms19124015. doi: 10.3390/ijms19124015. PubMed |
| New neurons use Slit-Robo signaling to migrate through the glial meshwork and approach a lesion for functional regeneration. Kaneko N, Herranz-Perez V, Otsuka T, Sano H, Ohno N, Omata T, Nguyen HB, Thai TQ, Nambu A, Kawaguchi Y, Garcia-Verdugo JM, Sawamoto K. Sci Adv. 2018 Dec 12;4(12):eaav0618. doi: 10.1126/sciadv.aav0618. eCollection 2018 Dec. PubMed |
| The histone chaperone complex FACT promotes proliferative switch of G0 cancer cells. Bi L, Xie C, Yao M, Thae Hnit SS, Vignarajan S, Wang Y, Wang Q, Xi Z, Xu H, Li Z, de Souza P, Tee A, Wong M, Liu T, Zhao X, Zhou J, Xu L, Dong Q. Int J Cancer. 2018 Dec 13. doi: 10.1002/ijc.32065. PubMed |
| Toll-like receptor chaperone HSP90B1 and the immune response to Mycobacteria. Graustein AD, Misch EA, Musvosvi M, Shey M, Shah JA, Seshadri C, Aguoju A, Bowman K, Mulenga H, Veldsman A, Hanekom WA, Hatherill M, Scriba TJ, Hawn TR. PLoS One. 2018 Dec 14;13(12):e0208940. doi: 10.1371/journal.pone.0208940. eCollection 2018. PubMed |
| Simultaneous Loss of Both Atypical Protein Kinase C Genes in the Intestinal Epithelium Drives Serrated Intestinal Cancer by Impairing Immunosurveillance. Nakanishi Y, Duran A, L'Hermitte A, Shelton PM, Nakanishi N, Reina-Campos M, Huang J, Soldevila F, Baaten BJG, Tauriello DVF, Castilla EA, Bhangoo MS, Bao F, Sigal D, Diaz-Meco MT, Moscat J. Immunity. 2018 Dec 18;49(6):1132-1147.e7. doi: 10.1016/j.immuni.2018.09.013. Epub 2018 Dec 11. PubMed |
| APOPT1/COA8 assists COX assembly and is oppositely regulated by UPS and ROS. Signes A, Cerutti R, Dickson AS, Beninca C, Hinchy EC, Ghezzi D, Carrozzo R, Bertini E, Murphy MP, Nathan JA, Viscomi C, Fernandez-Vizarra E, Zeviani M. EMBO Mol Med. 2019 Jan;11(1). pii: emmm.201809582. doi: 10.15252/emmm.201809582. PubMed |
| Clathrin-Mediated Endocytosis Regulates a Balance between Opposing Signals to Maintain the Pluripotent State of Embryonic Stem Cells. Narayana YV, Gadgil C, Mote RD, Rajan R, Subramanyam D. Stem Cell Reports. 2019 Jan 8;12(1):152-164. doi: 10.1016/j.stemcr.2018.11.018. Epub 2018 Dec 13. PubMed |
| Layer-by-layer assembled gold nanoshells for the intracellular delivery of miR-34a. Goyal R, Kapadia CH, Melamed JR, Riley RS, Day ES. Cell Mol Bioeng. 2018 Oct;11(5):383-396. doi: 10.1007/s12195-018-0535-x. Epub 2018 Jun 6. PubMed |
| Calretinin promotes invasiveness and EMT in malignant mesothelioma cells involving the activation of the FAK signaling pathway. Worthmuller J, Blum W, Pecze L, Salicio V, Schwaller B. Oncotarget. 2018 Nov 20;9(91):36256-36272. doi: 10.18632/oncotarget.26332. eCollection 2018 Nov 20. PubMed |
| FAM134B induces tumorigenesis and epithelial-to-mesenchymal transition via Akt signaling in hepatocellular carcinoma. Zhang ZQ, Chen J, Huang WQ, Ning D, Liu QM, Wang C, Zhang L, Ren L, Chu L, Liang HF, Fan HN, Zhang BX, Chen XP. Mol Oncol. 2019 Apr;13(4):792-810. doi: 10.1002/1878-0261.12429. Epub 2019 Jan 24. PubMed |
| Prostate transmembrane protein androgen induced 1 is induced by activation of osteoclasts and regulates bone resorption. Xu X, Hirata H, Shiraki M, Kamohara A, Nishioka K, Miyamoto H, Kukita T, Kukita A. FASEB J. 2019 Mar;33(3):4365-4375. doi: 10.1096/fj.201801573R. Epub 2018 Dec 17. PubMed |
Multiplexed orthogonal genome editing and transcriptional activation by Cas12a.
Breinig M, Schweitzer AY, Herianto AM, Revia S, Schaefer L, Wendler L, Cobos Galvez A, Tschaharganeh DF.
Nat Methods. 2019 Jan;16(1):51-54. doi: 10.1038/s41592-018-0262-1. Epub 2018 Dec 17.
PubMed
Associated Plasmids |
| Invasion of white matter tracts by glioma stem cells is regulated by a NOTCH1-SOX2 positive-feedback loop. Wang J, Xu SL, Duan JJ, Yi L, Guo YF, Shi Y, Li L, Yang ZY, Liao XM, Cai J, Zhang YQ, Xiao HL, Yin L, Wu H, Zhang JN, Lv SQ, Yang QK, Yang XJ, Jiang T, Zhang X, Bian XW, Yu SC. Nat Neurosci. 2019 Jan;22(1):91-105. doi: 10.1038/s41593-018-0285-z. Epub 2018 Dec 17. PubMed |
| A protein-protein interaction map of the TNF-induced NF-kappaB signal transduction pathway. Van Quickelberghe E, De Sutter D, van Loo G, Eyckerman S, Gevaert K. Sci Data. 2018 Dec 18;5:180289. doi: 10.1038/sdata.2018.289. PubMed |
| CRISPR-Mediated Approaches to Regulate YAP/TAZ Levels. Quinton RJ, Ganem NJ. Methods Mol Biol. 2019;1893:203-214. doi: 10.1007/978-1-4939-8910-2_16. PubMed |
| CCNG1 (Cyclin G1) regulation by mutant-P53 via induction of Notch3 expression promotes high-grade serous ovarian cancer (HGSOC) tumorigenesis and progression. Xu Y, Zhang Q, Miao C, Dongol S, Li Y, Jin C, Dong R, Li Y, Yang X, Kong B. Cancer Med. 2019 Jan;8(1):351-362. doi: 10.1002/cam4.1812. Epub 2018 Dec 18. PubMed |
| RNA interference screen identifies NAA10 as a regulator of PXR transcription. Oladimeji PO, Wright WC, Wu J, Chen T. Biochem Pharmacol. 2019 Feb;160:92-109. doi: 10.1016/j.bcp.2018.12.012. Epub 2018 Dec 16. PubMed |
| High PLK4 expression promotes tumor progression and induces epithelialmesenchymal transition by regulating the Wnt/betacatenin signaling pathway in colorectal cancer. Liao Z, Zhang H, Fan P, Huang Q, Dong K, Qi Y, Song J, Chen L, Liang H, Chen X, Zhang Z, Zhang B. Int J Oncol. 2019 Feb;54(2):479-490. doi: 10.3892/ijo.2018.4659. Epub 2018 Dec 10. PubMed |
| An amphipathic helix of vinexin alpha is necessary for a substrate stiffness-dependent conformational change in vinculin. Hino N, Ichikawa T, Kimura Y, Matsuda M, Ueda K, Kioka N. J Cell Sci. 2019 Jan 21;132(2). pii: jcs.217349. doi: 10.1242/jcs.217349. PubMed |
| Identification of Embryonic Neural Plate Border Stem Cells and Their Generation by Direct Reprogramming from Adult Human Blood Cells. Thier MC, Hommerding O, Panten J, Pinna R, Garcia-Gonzalez D, Berger T, Worsdorfer P, Assenov Y, Scognamiglio R, Przybylla A, Kaschutnig P, Becker L, Milsom MD, Jauch A, Utikal J, Herrmann C, Monyer H, Edenhofer F, Trumpp A. Cell Stem Cell. 2019 Jan 3;24(1):166-182.e13. doi: 10.1016/j.stem.2018.11.015. Epub 2018 Dec 20. PubMed |
| Genome-wide CRISPR Analysis Identifies Substrate-Specific Conjugation Modules in ER-Associated Degradation. Leto DE, Morgens DW, Zhang L, Walczak CP, Elias JE, Bassik MC, Kopito RR. Mol Cell. 2019 Jan 17;73(2):377-389.e11. doi: 10.1016/j.molcel.2018.11.015. Epub 2018 Dec 20. PubMed |
A Compact, High-Accuracy Cas9 with a Dinucleotide PAM for In Vivo Genome Editing.
Edraki A, Mir A, Ibraheim R, Gainetdinov I, Yoon Y, Song CQ, Cao Y, Gallant J, Xue W, Rivera-Perez JA, Sontheimer EJ.
Mol Cell. 2018 Dec 18. pii: S1097-2765(18)31033-5. doi: 10.1016/j.molcel.2018.12.003.
PubMed
Associated Plasmids |
| Inhibition of Dipeptidyl Peptidase-4 Accelerates Epithelial-Mesenchymal Transition and Breast Cancer Metastasis via the CXCL12/CXCR4/mTOR Axis. Yang F, Takagaki Y, Yoshitomi Y, Ikeda T, Li J, Kitada M, Kumagai A, Kawakita E, Shi S, Kanasaki K, Koya D. Cancer Res. 2019 Feb 15;79(4):735-746. doi: 10.1158/0008-5472.CAN-18-0620. Epub 2018 Dec 24. PubMed |
| Anti-Human Rhinovirus 1B Activity of Dexamethasone viaGCR-Dependent Autophagy Activation. Lee JS, Kim SR, Song JH, Lee YP, Ko HJ. Osong Public Health Res Perspect. 2018 Dec;9(6):334-339. doi: 10.24171/j.phrp.2018.9.6.07. PubMed |
| Identification of Novel Protein Targets of Dimethyl Fumarate Modification in Neurons and Astrocytes Reveals Actions Independent of Nrf2 Stabilization. Piroli GG, Manuel AM, Patel T, Walla MD, Shi L, Lanci SA, Wang J, Galloway A, Ortinski PI, Smith DS, Frizzell N. Mol Cell Proteomics. 2019 Mar;18(3):504-519. doi: 10.1074/mcp.RA118.000922. Epub 2018 Dec 26. PubMed |
| Dual Mechanisms of LYN Kinase Dysregulation Drive Aggressive Behavior in Breast Cancer Cells. Tornillo G, Knowlson C, Kendrick H, Cooke J, Mirza H, Aurrekoetxea-Rodriguez I, Vivanco MDM, Buckley NE, Grigoriadis A, Smalley MJ. Cell Rep. 2018 Dec 26;25(13):3674-3692.e10. doi: 10.1016/j.celrep.2018.11.103. PubMed |
| Sensitive ADAR editing reporter in cancer cells enables high-throughput screening of small molecule libraries. Fritzell K, Xu LD, Otrocka M, Andreasson C, Ohman M. Nucleic Acids Res. 2019 Feb 28;47(4):e22. doi: 10.1093/nar/gky1228. PubMed |
Creation of versatile cloning platforms for transgene expression and dCas9-based epigenome editing.
Haldeman JM, Conway AE, Arlotto ME, Slentz DH, Muoio DM, Becker TC, Newgard CB.
Nucleic Acids Res. 2018 Dec 27. pii: 5264291. doi: 10.1093/nar/gky1286.
PubMed
Associated Plasmids |
Alternative 3' UTRs direct localization of functionally diverse protein isoforms in neuronal compartments.
Ciolli Mattioli C, Rom A, Franke V, Imami K, Arrey G, Terne M, Woehler A, Akalin A, Ulitsky I, Chekulaeva M.
Nucleic Acids Res. 2018 Dec 22. pii: 5258023. doi: 10.1093/nar/gky1270.
PubMed
Associated Plasmids |
| Overcoming Challenges of Hepatitis C Virus Envelope Glycoprotein Production in Mammalian Cells. Yost SA, Whidby J, Khan AG, Wang Y, Marcotrigiano J. Methods Mol Biol. 2019;1911:305-316. doi: 10.1007/978-1-4939-8976-8_21. PubMed |
| Proteolytic cleavage of Beclin 1 exacerbates neurodegeneration. Bieri G, Lucin KM, O'Brien CE, Zhang H, Villeda SA, Wyss-Coray T. Mol Neurodegener. 2018 Dec 29;13(1):68. doi: 10.1186/s13024-018-0302-4. PubMed |
| Common ELF1 deletion in prostate cancer bolsters oncogenic ETS function, inhibits senescence and promotes docetaxel resistance. Budka JA, Ferris MW, Capone MJ, Hollenhorst PC. Genes Cancer. 2018 May;9(5-6):198-214. doi: 10.18632/genesandcancer.182. PubMed |
| SG formation relies on eIF4GI-G3BP interaction which is targeted by picornavirus stress antagonists. Yang X, Hu Z, Zhang Q, Fan S, Zhong Y, Guo D, Qin Y, Chen M. Cell Discov. 2019 Jan 1;5:1. doi: 10.1038/s41421-018-0068-4. eCollection 2019. PubMed |
| CD46 Null Packaging Cell Line Improves Measles Lentiviral Vector Production and Gene Delivery to Hematopoietic Stem and Progenitor Cells. Ozog S, Chen CX, Simpson E, Garijo O, Timberlake ND, Minder P, Verhoeyen E, Torbett BE. Mol Ther Methods Clin Dev. 2018 Nov 24;13:27-39. doi: 10.1016/j.omtm.2018.11.006. eCollection 2019 Jun 14. PubMed |
| DHHC4 and DHHC5 Facilitate Fatty Acid Uptake by Palmitoylating and Targeting CD36 to the Plasma Membrane. Wang J, Hao JW, Wang X, Guo H, Sun HH, Lai XY, Liu LY, Zhu M, Wang HY, Li YF, Yu LY, Xie C, Wang HR, Mo W, Zhou HM, Chen S, Liang G, Zhao TJ. Cell Rep. 2019 Jan 2;26(1):209-221.e5. doi: 10.1016/j.celrep.2018.12.022. PubMed |
| SHP2 Drives Adaptive Resistance to ERK Signaling Inhibition in Molecularly Defined Subsets of ERK-Dependent Tumors. Ahmed TA, Adamopoulos C, Karoulia Z, Wu X, Sachidanandam R, Aaronson SA, Poulikakos PI. Cell Rep. 2019 Jan 2;26(1):65-78.e5. doi: 10.1016/j.celrep.2018.12.013. PubMed |
| UBQLN4 Represses Homologous Recombination and Is Overexpressed in Aggressive Tumors. Jachimowicz RD, Beleggia F, Isensee J, Velpula BB, Goergens J, Bustos MA, Doll MA, Shenoy A, Checa-Rodriguez C, Wiederstein JL, Baranes-Bachar K, Bartenhagen C, Hertwig F, Teper N, Nishi T, Schmitt A, Distelmaier F, Ludecke HJ, Albrecht B, Kruger M, Schumacher B, Geiger T, Hoon DSB, Huertas P, Fischer M, Hucho T, Peifer M, Ziv Y, Reinhardt HC, Wieczorek D, Shiloh Y. Cell. 2019 Jan 24;176(3):505-519.e22. doi: 10.1016/j.cell.2018.11.024. Epub 2019 Jan 3. PubMed |
| METTL13 Methylation of eEF1A Increases Translational Output to Promote Tumorigenesis. Liu S, Hausmann S, Carlson SM, Fuentes ME, Francis JW, Pillai R, Lofgren SM, Hulea L, Tandoc K, Lu J, Li A, Nguyen ND, Caporicci M, Kim MP, Maitra A, Wang H, Wistuba II, Porco JA Jr, Bassik MC, Elias JE, Song J, Topisirovic I, Van Rechem C, Mazur PK, Gozani O. Cell. 2019 Jan 24;176(3):491-504.e21. doi: 10.1016/j.cell.2018.11.038. Epub 2019 Jan 3. PubMed |
| Chemically induced vesiculation as a platform for studying TMEM16F activity. Han TW, Ye W, Bethel NP, Zubia M, Kim A, Li KH, Burlingame AL, Grabe M, Jan YN, Jan LY. Proc Natl Acad Sci U S A. 2019 Jan 22;116(4):1309-1318. doi: 10.1073/pnas.1817498116. Epub 2019 Jan 8. PubMed |
| Intratumoral expression using a NFkB-based promoter enhances IL12 antitumor efficacy. Garaulet G, Perez-Chacon G, Alarcon H, Alfranca A, Mulero F, Martinez-Torrecuadrada J, Zapata JM, Rodriguez A. Cancer Gene Ther. 2019 Jan 9. pii: 10.1038/s41417-018-0076-4. doi: 10.1038/s41417-018-0076-4. PubMed |
| Targeting JNK pathway promotes human hematopoietic stem cell expansion. Xiao X, Lai W, Xie H, Liu Y, Guo W, Liu Y, Li Y, Li Y, Zhang J, Chen W, Shi M, Shang L, Yin M, Wang C, Deng H. Cell Discov. 2019 Jan 8;5:2. doi: 10.1038/s41421-018-0072-8. eCollection 2019. PubMed |
| An efficient method for the transduction of primary pediatric glioma neurospheres. Meel MH, Metselaar DS, Waranecki P, Kaspers GJL, Hulleman E. MethodsX. 2018 Feb 27;5:173-183. doi: 10.1016/j.mex.2018.02.006. eCollection 2018. PubMed |
| Development of a Novel Anti-CD19 Chimeric Antigen Receptor: A Paradigm for an Affordable CAR T Cell Production at Academic Institutions. Castella M, Boronat A, Martin-Ibanez R, Rodriguez V, Sune G, Caballero M, Marzal B, Perez-Amill L, Martin-Antonio B, Castano J, Bueno C, Balague O, Gonzalez-Navarro EA, Serra-Pages C, Engel P, Vilella R, Benitez-Ribas D, Ortiz-Maldonado V, Cid J, Tabera J, Canals JM, Lozano M, Baumann T, Vilarrodona A, Trias E, Campo E, Menendez P, Urbano-Ispizua A, Yague J, Perez-Galan P, Rives S, Delgado J, Juan M. Mol Ther Methods Clin Dev. 2018 Dec 6;12:134-144. doi: 10.1016/j.omtm.2018.11.010. eCollection 2019 Mar 15. PubMed |
| Multicolour In Vivo Bioluminescence Imaging Using a NanoLuc-Based BRET Reporter in Combination with Firefly Luciferase. Taylor A, Sharkey J, Plagge A, Wilm B, Murray P. Contrast Media Mol Imaging. 2018 Dec 3;2018:2514796. doi: 10.1155/2018/2514796. eCollection 2018. PubMed |
| Genome-wide analysis of ETV1 targets: Insights into the role of ETV1 in tumor progression. Eid W, Abdel-Rehim W. J Cell Biochem. 2019 Jan 10. doi: 10.1002/jcb.28169. PubMed |
| Enhancer Domains in Gastrointestinal Stromal Tumor Regulate KIT Expression and Are Targetable by BET Bromodomain Inhibition. Hemming ML, Lawlor MA, Andersen JL, Hagan T, Chipashvili O, Scott TG, Raut CP, Sicinska E, Armstrong SA, Demetri GD, Bradner JE. Cancer Res. 2019 Mar 1;79(5):994-1009. doi: 10.1158/0008-5472.CAN-18-1888. Epub 2019 Jan 10. PubMed |
CRISPR-Cas9 Circular Permutants as Programmable Scaffolds for Genome Modification.
Oakes BL, Fellmann C, Rishi H, Taylor KL, Ren SM, Nadler DC, Yokoo R, Arkin AP, Doudna JA, Savage DF.
Cell. 2019 Jan 10;176(1-2):254-267.e16. doi: 10.1016/j.cell.2018.11.052.
PubMed
Associated Plasmids |
| Establishment and characterization of an immortalized renal cell line of the Chinese tree shrew (Tupaia belangeri chinesis). Gu T, Yu D, Li Y, Xu L, Yao YL, Yao YG. Appl Microbiol Biotechnol. 2019 Mar;103(5):2171-2180. doi: 10.1007/s00253-019-09615-3. Epub 2019 Jan 12. PubMed |
| TIPE3 is a regulator of cell apoptosis in glioblastoma. Yuan F, Liu B, Xu Y, Li Y, Sun Q, Xu P, Geng R, Den G, Yang J, Zhang S, Gao L, Liao J, Liu J, Yang X, Tan Y, Chen Q. Cancer Lett. 2019 Apr 1;446:1-14. doi: 10.1016/j.canlet.2018.12.019. Epub 2019 Jan 11. PubMed |
| Generation of porcine induced-pluripotent stem cells from Sertoli cells. Setthawong P, Phakdeedindan P, Tiptanavattana N, Rungarunlert S, Techakumphu M, Tharasanit T. Theriogenology. 2019 Mar 15;127:32-40. doi: 10.1016/j.theriogenology.2018.12.033. Epub 2018 Dec 21. PubMed |
| IL-1beta Inflammatory Cytokine-Induced TP63 Isoform NP63alpha Signaling Cascade Contributes to Cisplatin Resistance in Human Breast Cancer Cells. Mendoza-Rodriguez MG, Ayala-Sumuano JT, Garcia-Morales L, Zamudio-Meza H, Perez-Yepez EA, Meza I. Int J Mol Sci. 2019 Jan 11;20(2). pii: ijms20020270. doi: 10.3390/ijms20020270. PubMed |
| Non-Invasive Longitudinal Bioluminescence Imaging of Human Mesoangioblasts in Bioengineered Esophagi. Crowley C, Butler CR, Camilli C, Hynds RE, Kolluri KK, Janes SM, De Coppi P, Urbani L. Tissue Eng Part C Methods. 2019 Feb;25(2):103-113. doi: 10.1089/ten.TEC.2018.0351. PubMed |
| Requirement for PRC1 subunit BMI1 in host gene activation by Epstein-Barr virus protein EBNA3C. Paschos K, Bazot Q, Lees J, Farrell PJ, Allday MJ. Nucleic Acids Res. 2019 Jan 15. pii: 5289486. doi: 10.1093/nar/gky1323. PubMed |
| Fever Promotes T Lymphocyte Trafficking via a Thermal Sensory Pathway Involving Heat Shock Protein 90 and alpha4 Integrins. Lin C, Zhang Y, Zhang K, Zheng Y, Lu L, Chang H, Yang H, Yang Y, Wan Y, Wang S, Yuan M, Yan Z, Zhang R, He Y, Ge G, Wu D, Chen J. Immunity. 2019 Jan 15;50(1):137-151.e6. doi: 10.1016/j.immuni.2018.11.013. PubMed |
| TRIM28 promotes HIV-1 latency by SUMOylating CDK9 and inhibiting P-TEFb. Ma X, Yang T, Luo Y, Wu L, Jiang Y, Song Z, Pan T, Liu B, Liu G, Liu J, Yu F, He Z, Zhang W, Yang J, Liang L, Guan Y, Zhang X, Li L, Cai W, Tang X, Gao S, Deng K, Zhang H. Elife. 2019 Jan 17;8. pii: 42426. doi: 10.7554/eLife.42426. PubMed |
| Activating PTEN Tumor Suppressor Expression with the CRISPR/dCas9 System. Moses C, Nugent F, Waryah CB, Garcia-Bloj B, Harvey AR, Blancafort P. Mol Ther Nucleic Acids. 2019 Mar 1;14:287-300. doi: 10.1016/j.omtn.2018.12.003. Epub 2018 Dec 14. PubMed |
| Myosin IIB assembly state determines its mechanosensitive dynamics. Schiffhauer ES, Ren Y, Iglesias VA, Kothari P, Iglesias PA, Robinson DN. J Cell Biol. 2019 Mar 4;218(3):895-908. doi: 10.1083/jcb.201806058. Epub 2019 Jan 17. PubMed |
| Epigenomic profiling of myelofibrosis reveals widespread DNA methylation changes in enhancer elements and ZFP36L1 as a potential tumor suppressor gene that is epigenetically regulated. Martinez-Calle N, Pascual M, Ordonez R, Eneriz ESJ, Kulis M, Miranda E, Guruceaga E, Segura V, Larrayoz MJ, Bellosillo B, Calasanz MJ, Besses C, Rifon J, Martin-Subero JI, Agirre X, Prosper F. Haematologica. 2019 Aug;104(8):1572-1579. doi: 10.3324/haematol.2018.204917. Epub 2019 Jan 17. PubMed |
| The circadian E3 ligase complex SCF(FBXL3+CRY) targets TLK2. Correia SP, Chan AB, Vaughan M, Zolboot N, Perea V, Huber AL, Kriebs A, Moresco JJ, Yates JR 3rd, Lamia KA. Sci Rep. 2019 Jan 17;9(1):198. doi: 10.1038/s41598-018-36618-3. PubMed |
| circRNA of AR-suppressed PABPC1 91 bp enhances the cytotoxicity of natural killer cells against hepatocellular carcinoma via upregulating UL16 binding protein 1. Ma Y, Zhang C, Zhang B, Yu H, Yu Q. Oncol Lett. 2019 Jan;17(1):388-397. doi: 10.3892/ol.2018.9606. Epub 2018 Oct 22. PubMed |
| Soluble CD93 is an apoptotic cell opsonin recognized by alphax beta2. Blackburn JWD, Lau DHC, Liu EY, Ellins J, Vrieze AM, Pawlak EN, Dikeakos JD, Heit B. Eur J Immunol. 2019 Apr;49(4):600-610. doi: 10.1002/eji.201847801. Epub 2019 Feb 7. PubMed |
Redundancy of human ATG4 protease isoforms in autophagy and LC3/GABARAP processing revealed in cells.
Agrotis A, Pengo N, Burden JJ, Ketteler R.
Autophagy. 2019 Jan 21. doi: 10.1080/15548627.2019.1569925.
PubMed
Associated Plasmids |
| FOXO3-Engineered Human ESC-Derived Vascular Cells Promote Vascular Protection and Regeneration. Yan P, Li Q, Wang L, Lu P, Suzuki K, Liu Z, Lei J, Li W, He X, Wang S, Ding J, Chan P, Zhang W, Song M, Izpisua Belmonte JC, Qu J, Tang F, Liu GH. Cell Stem Cell. 2019 Mar 7;24(3):447-461.e8. doi: 10.1016/j.stem.2018.12.002. Epub 2019 Jan 17. PubMed |
| Direct in vivo application of induced pluripotent stem cells is feasible and can be safe. Xiang M, Lu M, Quan J, Xu M, Meng D, Cui A, Li N, Liu Y, Lu P, Kang X, Wang X, Sun N, Zhao M, Liang Q, Le L, Wang X, Zhang J, Chen S. Theranostics. 2019 Jan 1;9(1):290-310. doi: 10.7150/thno.28671. eCollection 2019. PubMed |
| The PI3K/AKT signaling pathway regulates ABCG2 expression and confers resistance to chemotherapy in human multiple myeloma. Wang L, Lin N, Li Y. Oncol Rep. 2019 Mar;41(3):1678-1690. doi: 10.3892/or.2019.6968. Epub 2019 Jan 11. PubMed |
A genetically encoded near-infrared fluorescent calcium ion indicator.
Qian Y, Piatkevich KD, Mc Larney B, Abdelfattah AS, Mehta S, Murdock MH, Gottschalk S, Molina RS, Zhang W, Chen Y, Wu J, Drobizhev M, Hughes TE, Zhang J, Schreiter ER, Shoham S, Razansky D, Boyden ES, Campbell RE.
Nat Methods. 2019 Feb;16(2):171-174. doi: 10.1038/s41592-018-0294-6. Epub 2019 Jan 21.
PubMed
Associated Plasmids |
| The lysine-specific methyltransferase KMT2C/MLL3 regulates DNA repair components in cancer. Rampias T, Karagiannis D, Avgeris M, Polyzos A, Kokkalis A, Kanaki Z, Kousidou E, Tzetis M, Kanavakis E, Stravodimos K, Manola KN, Pantelias GE, Scorilas A, Klinakis A. EMBO Rep. 2019 Mar;20(3). pii: embr.201846821. doi: 10.15252/embr.201846821. Epub 2019 Jan 21. PubMed |
| MBD3/NuRD loss participates with KDM6A program to promote DOCK5/8 expression and Rac GTPase activation in human acute myeloid leukemia. Biswas M, Chatterjee SS, Boila LD, Chakraborty S, Banerjee D, Sengupta A. FASEB J. 2019 Apr;33(4):5268-5286. doi: 10.1096/fj.201801035R. Epub 2019 Jan 22. PubMed |
| HDAC1 and HDAC2 Double Knockout Triggers Cell Apoptosis in Advanced Thyroid Cancer. Lin CL, Tsai ML, Lin CY, Hsu KW, Hsieh WS, Chi WM, Huang LC, Lee CH. Int J Mol Sci. 2019 Jan 21;20(2). pii: ijms20020454. doi: 10.3390/ijms20020454. PubMed |
| Long non-coding RNA PSMB8-AS1 regulates influenza virus replication. More S, Zhu Z, Lin K, Huang C, Pushparaj S, Liang Y, Sathiaseelan R, Yang X, Liu L. RNA Biol. 2019 Mar;16(3):340-353. doi: 10.1080/15476286.2019.1572448. Epub 2019 Jan 28. PubMed |
| Endothelial-specific deletion of Ets-1 attenuates Angiotensin II-induced cardiac fibrosis via suppression of endothelial-to-mesenchymal transition. Xu L, Fu M, Chen D, Han W, Ostrowski MC, Grossfeld P, Gao P, Ye M. BMB Rep. 2019 Oct;52(10):595-600. PubMed |
| Phosphoglycolate has profound metabolic effects but most likely no role in a metabolic DNA response in cancer cell lines. Gerin I, Bury M, Baldin F, Graff J, Van Schaftingen E, Bommer GT. Biochem J. 2019 Feb 19;476(4):629-643. doi: 10.1042/BCJ20180435. PubMed |
| HIV-1 nuclear import in macrophages is regulated by CPSF6-capsid interactions at the nuclear pore complex. Bejarano DA, Peng K, Laketa V, Borner K, Jost KL, Lucic B, Glass B, Lusic M, Muller B, Krausslich HG. Elife. 2019 Jan 23;8. pii: 41800. doi: 10.7554/eLife.41800. PubMed |
| Longitudinal Visualization of Viable Cancer Cell Intratumoral Distribution in Mouse Models Using Oatp1a1-Enhanced Magnetic Resonance Imaging. Nystrom NN, Hamilton AM, Xia W, Liu S, Scholl TJ, Ronald JA. Invest Radiol. 2019 May;54(5):302-311. doi: 10.1097/RLI.0000000000000542. PubMed |
| Gain-of-Function Mutations of SLC16A11 Contribute to the Pathogenesis of Type 2 Diabetes. Zhao Y, Feng Z, Zhang Y, Sun Y, Chen Y, Liu X, Li S, Zhou T, Chen L, Wei Y, Ma D, Lui KO, Ying H, Chen Y, Ding Q. Cell Rep. 2019 Jan 22;26(4):884-892.e4. doi: 10.1016/j.celrep.2018.12.100. PubMed |
| Neuron-Specific Gene 2 (NSG2) Encodes an AMPA Receptor Interacting Protein That Modulates Excitatory Neurotransmission. Chander P, Kennedy MJ, Winckler B, Weick JP. eNeuro. 2019 Jan 24;6(1). pii: eN-NWR-0292-18. doi: 10.1523/ENEURO.0292-18.2018. eCollection 2019 Jan-Feb. PubMed |
| Role of heparan sulfate in the Zika virus entry, replication, and cell death. Gao H, Lin Y, He J, Zhou S, Liang M, Huang C, Li X, Liu C, Zhang P. Virology. 2019 Mar;529:91-100. doi: 10.1016/j.virol.2019.01.019. Epub 2019 Jan 18. PubMed |
| Exogenous Monounsaturated Fatty Acids Promote a Ferroptosis-Resistant Cell State. Magtanong L, Ko PJ, To M, Cao JY, Forcina GC, Tarangelo A, Ward CC, Cho K, Patti GJ, Nomura DK, Olzmann JA, Dixon SJ. Cell Chem Biol. 2019 Mar 21;26(3):420-432.e9. doi: 10.1016/j.chembiol.2018.11.016. Epub 2019 Jan 24. PubMed |
| Targeting the Vulnerability of Glutathione Metabolism in ARID1A-Deficient Cancers. Ogiwara H, Takahashi K, Sasaki M, Kuroda T, Yoshida H, Watanabe R, Maruyama A, Makinoshima H, Chiwaki F, Sasaki H, Kato T, Okamoto A, Kohno T. Cancer Cell. 2019 Feb 11;35(2):177-190.e8. doi: 10.1016/j.ccell.2018.12.009. Epub 2019 Jan 24. PubMed |
| Cullin5 deficiency promotes small-cell lung cancer metastasis by stabilizing integrin beta1. Zhao G, Gong L, Su D, Jin Y, Guo C, Yue M, Yao S, Qin Z, Ye Y, Tang Y, Wu Q, Zhang J, Cui B, Ding Q, Huang H, Hu L, Chen Y, Zhang P, Hu G, Chen L, Wong KK, Gao D, Ji H. J Clin Invest. 2019 Mar 1;129(3):972-987. doi: 10.1172/JCI122779. Epub 2019 Jan 28. PubMed |
| Therapeutic efficacy of intra-articular delivery of encapsulated human mesenchymal stem cells on early stage osteoarthritis. McKinney JM, Doan TN, Wang L, Deppen J, Reece DS, Pucha KA, Ginn S, Levit RD, Willett NJ. Eur Cell Mater. 2019 Jan 29;37:42-59. doi: 10.22203/eCM.v037a04. PubMed |
| REST and Neural Gene Network Dysregulation in iPSC Models of Alzheimer's Disease. Meyer K, Feldman HM, Lu T, Drake D, Lim ET, Ling KH, Bishop NA, Pan Y, Seo J, Lin YT, Su SC, Church GM, Tsai LH, Yankner BA. Cell Rep. 2019 Jan 29;26(5):1112-1127.e9. doi: 10.1016/j.celrep.2019.01.023. PubMed |
| The EF-Hand Protein CALML6 Suppresses Antiviral Innate Immunity by Impairing IRF3 Dimerization. Wang Z, Sheng C, Yao C, Chen H, Wang D, Chen S. Cell Rep. 2019 Jan 29;26(5):1273-1285.e5. doi: 10.1016/j.celrep.2019.01.030. PubMed |
| Integrated Phosphoproteome and Transcriptome Analysis Reveals Chlamydia-Induced Epithelial-to-Mesenchymal Transition in Host Cells. Zadora PK, Chumduri C, Imami K, Berger H, Mi Y, Selbach M, Meyer TF, Gurumurthy RK. Cell Rep. 2019 Jan 29;26(5):1286-1302.e8. doi: 10.1016/j.celrep.2019.01.006. PubMed |
| Multivalent Role of Human TFIID in Recruiting Elongation Components at the Promoter-Proximal Region for Transcriptional Control. Yadav D, Ghosh K, Basu S, Roeder RG, Biswas D. Cell Rep. 2019 Jan 29;26(5):1303-1317.e7. doi: 10.1016/j.celrep.2019.01.012. PubMed |
| Regenerative potential of mouse embryonic stem cell-derived PDGFRalpha(+) cardiac lineage committed cells in infarcted myocardium. Hong SP, Song S, Lee S, Jo H, Kim HK, Han J, Park JH, Cho SW. World J Stem Cells. 2019 Jan 26;11(1):44-54. doi: 10.4252/wjsc.v11.i1.44. PubMed |
| Wild-Type p53 Promotes Cancer Metabolic Switch by Inducing PUMA-Dependent Suppression of Oxidative Phosphorylation. Kim J, Yu L, Chen W, Xu Y, Wu M, Todorova D, Tang Q, Feng B, Jiang L, He J, Chen G, Fu X, Xu Y. Cancer Cell. 2019 Feb 11;35(2):191-203.e8. doi: 10.1016/j.ccell.2018.12.012. Epub 2019 Jan 31. PubMed |
| Pharmacological Targeting of STK19 Inhibits Oncogenic NRAS-Driven Melanomagenesis. Yin C, Zhu B, Zhang T, Liu T, Chen S, Liu Y, Li X, Miao X, Li S, Mi X, Zhang J, Li L, Wei G, Xu ZX, Gao X, Huang C, Wei Z, Goding CR, Wang P, Deng X, Cui R. Cell. 2019 Feb 21;176(5):1113-1127.e16. doi: 10.1016/j.cell.2019.01.002. Epub 2019 Jan 31. PubMed |
| De Novo PITX1 Expression Controls Bi-Stable Transcriptional Circuits to Govern Self-Renewal and Differentiation in Squamous Cell Carcinoma. Sastre-Perona A, Hoang-Phou S, Leitner MC, Okuniewska M, Meehan S, Schober M. Cell Stem Cell. 2019 Mar 7;24(3):390-404.e8. doi: 10.1016/j.stem.2019.01.003. Epub 2019 Jan 31. PubMed |
| F-box protein FBXO16 functions as a tumor suppressor by attenuating nuclear beta-catenin function. Paul D, Islam S, Manne RK, Dinesh US, Malonia SK, Maity B, Boppana R, Rapole S, Shetty PK, Santra MK. J Pathol. 2019 Jul;248(3):266-279. doi: 10.1002/path.5252. Epub 2019 Mar 8. PubMed |
| Ultraviolet B-induced Otx2 expression in lens epithelial cells promotes epithelial-mesenchymal transition. Yoshitomi Y, Osada H, Satake H, Kojima M, Saito-Takatsuji H, Ikeda T, Yoshitake Y, Ishigaki Y, Kubo E, Sasaki H, Yonekura H. Biol Open. 2019 Feb 18;8(2). pii: bio.035691. doi: 10.1242/bio.035691. PubMed |
| Label-free Quantitative Analysis of Protein Expression Alterations in miR-26a-Knockout HeLa Cells using SWATH-MS Technology. Shen H, Li L, Teng Z, Meng T, Kong X, Hu Y, Zhu Y, Ma L. Sci Rep. 2019 Feb 4;9(1):1399. doi: 10.1038/s41598-018-34904-8. PubMed |
| Targeting NOTCH activation in small cell lung cancer through LSD1 inhibition. Augert A, Eastwood E, Ibrahim AH, Wu N, Grunblatt E, Basom R, Liggitt D, Eaton KD, Martins R, Poirier JT, Rudin CM, Milletti F, Cheng WY, Mack F, MacPherson D. Sci Signal. 2019 Feb 5;12(567). pii: 12/567/eaau2922. doi: 10.1126/scisignal.aau2922. PubMed |
| A Genome-wide Haploid Genetic Screen Identifies Regulators of Glutathione Abundance and Ferroptosis Sensitivity. Cao JY, Poddar A, Magtanong L, Lumb JH, Mileur TR, Reid MA, Dovey CM, Wang J, Locasale JW, Stone E, Cole SPC, Carette JE, Dixon SJ. Cell Rep. 2019 Feb 5;26(6):1544-1556.e8. doi: 10.1016/j.celrep.2019.01.043. PubMed |
Specific, sensitive and stable reporting of human mesenchymal stromal cell chondrogenesis.
De La Vega RE, Scheu M, Brown LA, Evans C, Ferreira E, Porter RM.
Tissue Eng Part C Methods. 2019 Feb 6. doi: 10.1089/ten.TEC.2018.0295.
PubMed
Associated Plasmids |
| Tracing cellular heterogeneity in pooled genetic screens via multi-level barcoding. Boettcher M, Covarrubias S, Biton A, Blau J, Wang H, Zaitlen N, McManus MT. BMC Genomics. 2019 Feb 6;20(1):107. doi: 10.1186/s12864-019-5480-0. PubMed |
| Resveratrol enhances pluripotency of mouse embryonic stem cells by activating AMPK/Ulk1 pathway. Suvorova II, Knyazeva AR, Petukhov AV, Aksenov ND, Pospelov VA. Cell Death Discov. 2019 Feb 4;5:61. doi: 10.1038/s41420-019-0137-y. eCollection 2019. PubMed |
| Genome-Scale CRISPR/Cas9 Screening Reveals Squalene Epoxidase as a Susceptibility Factor for Cytotoxicity of Malformin A1. Koizumi Y, Fukushima J, Kobayashi Y, Kadowaki A, Natsui M, Yamaguchi T, Imai Y, Sugiyama T, Kuba K. Chembiochem. 2019 Jun 14;20(12):1563-1568. doi: 10.1002/cbic.201800769. Epub 2019 Apr 18. PubMed |
| Widespread and Functional RNA Circularization in Localized Prostate Cancer. Chen S, Huang V, Xu X, Livingstone J, Soares F, Jeon J, Zeng Y, Hua JT, Petricca J, Guo H, Wang M, Yousif F, Zhang Y, Donmez N, Ahmed M, Volik S, Lapuk A, Chua MLK, Heisler LE, Foucal A, Fox NS, Fraser M, Bhandari V, Shiah YJ, Guan J, Li J, Orain M, Picard V, Hovington H, Bergeron A, Lacombe L, Fradet Y, Tetu B, Liu S, Feng F, Wu X, Shao YW, Komor MA, Sahinalp C, Collins C, Hoogstrate Y, de Jong M, Fijneman RJA, Fei T, Jenster G, van der Kwast T, Bristow RG, Boutros PC, He HH. Cell. 2019 Feb 7;176(4):831-843.e22. doi: 10.1016/j.cell.2019.01.025. PubMed |
| Niclosamide activates the NLRP3 inflammasome by intracellular acidification and mitochondrial inhibition. Thi Tran U, Kitami T. Commun Biol. 2019 Jan 3;2:2. doi: 10.1038/s42003-018-0244-y. eCollection 2019. PubMed |
| Hectd3 promotes pathogenic Th17 lineage through Stat3 activation and Malt1 signaling in neuroinflammation. Cho JJ, Xu Z, Parthasarathy U, Drashansky TT, Helm EY, Zuniga AN, Lorentsen KJ, Mansouri S, Cho JY, Edelmann MJ, Duong DM, Gehring T, Seeholzer T, Krappmann D, Uddin MN, Califano D, Wang RL, Jin L, Li H, Lv D, Zhou D, Zhou L, Avram D. Nat Commun. 2019 Feb 11;10(1):701. doi: 10.1038/s41467-019-08605-3. PubMed |
| Identification of diterpenoid compounds that interfere with Fli-1 DNA binding to suppress leukemogenesis. Liu T, Xia L, Yao Y, Yan C, Fan Y, Gajendran B, Yang J, Li YJ, Chen J, Filmus J, Spaner DE, Zacksenhaus E, Hao X, Ben-David Y. Cell Death Dis. 2019 Feb 11;10(2):117. doi: 10.1038/s41419-019-1363-1. PubMed |
| POH1 contributes to hyperactivation of TGF-beta signaling and facilitates hepatocellular carcinoma metastasis through deubiquitinating TGF-beta receptors and caveolin-1. Wang B, Xu X, Yang Z, Zhang L, Liu Y, Ma A, Xu G, Tang M, Jing T, Wu L, Liu Y. EBioMedicine. 2019 Mar;41:320-332. doi: 10.1016/j.ebiom.2019.01.058. Epub 2019 Feb 7. PubMed |
| Nuclear RNA foci from C9ORF72 expansion mutation form paraspeckle-like bodies. Bajc Cesnik A, Darovic S, Prpar Mihevc S, Stalekar M, Malnar M, Motaln H, Lee YB, Mazej J, Pohleven J, Grosch M, Modic M, Fonovic M, Turk B, Drukker M, Shaw CE, Rogelj B. J Cell Sci. 2019 Mar 7;132(5). pii: jcs.224303. doi: 10.1242/jcs.224303. PubMed |
| p53 Is a Master Regulator of Proteostasis in SMARCB1-Deficient Malignant Rhabdoid Tumors. Carugo A, Minelli R, Sapio L, Soeung M, Carbone F, Robinson FS, Tepper J, Chen Z, Lovisa S, Svelto M, Amin S, Srinivasan S, Del Poggetto E, Loponte S, Puca F, Dey P, Malouf GG, Su X, Li L, Lopez-Terrada D, Rakheja D, Lazar AJ, Netto GJ, Rao P, Sgambato A, Maitra A, Tripathi DN, Walker CL, Karam JA, Heffernan TP, Viale A, Roberts CWM, Msaouel P, Tannir NM, Draetta GF, Genovese G. Cancer Cell. 2019 Feb 11;35(2):204-220.e9. doi: 10.1016/j.ccell.2019.01.006. PubMed |
| Aging-like Spontaneous Epigenetic Silencing Facilitates Wnt Activation, Stemness, and Braf(V600E)-Induced Tumorigenesis. Tao Y, Kang B, Petkovich DA, Bhandari YR, In J, Stein-O'Brien G, Kong X, Xie W, Zachos N, Maegawa S, Vaidya H, Brown S, Chiu Yen RW, Shao X, Thakor J, Lu Z, Cai Y, Zhang Y, Mallona I, Peinado MA, Zahnow CA, Ahuja N, Fertig E, Issa JP, Baylin SB, Easwaran H. Cancer Cell. 2019 Feb 11;35(2):315-328.e6. doi: 10.1016/j.ccell.2019.01.005. PubMed |
| Human Cytomegalovirus Immediate Early 86-kDa Protein Blocks Transcription and Induces Degradation of the Immature Interleukin-1beta Protein during Virion-Mediated Activation of the AIM2 Inflammasome. Botto S, Abraham J, Mizuno N, Pryke K, Gall B, Landais I, Streblow DN, Fruh KJ, DeFilippis VR. MBio. 2019 Feb 12;10(1). pii: mBio.02510-18. doi: 10.1128/mBio.02510-18. PubMed |
| Experimental and Computational Approaches for Single-Cell Enhancer Perturbation Assay. Xie S, Hon GC. Methods Mol Biol. 2019;1935:203-221. doi: 10.1007/978-1-4939-9057-3_14. PubMed |
Delivering SaCas9 mRNA by lentivirus-like bionanoparticles for transient expression and efficient genome editing.
Lu B, Javidi-Parsijani P, Makani V, Mehraein-Ghomi F, Sarhan WM, Sun D, Yoo KW, Atala ZP, Lyu P, Atala A.
Nucleic Acids Res. 2019 Feb 13. pii: 5316732. doi: 10.1093/nar/gkz093.
PubMed
Associated Plasmids |
| Release of Immunomodulatory Ebola Virus Glycoprotein-Containing Microvesicles Is Suppressed by Tetherin in a Species-Specific Manner. Nehls J, Businger R, Hoffmann M, Brinkmann C, Fehrenbacher B, Schaller M, Maurer B, Schonfeld C, Kramer D, Hailfinger S, Pohlmann S, Schindler M. Cell Rep. 2019 Feb 12;26(7):1841-1853.e6. doi: 10.1016/j.celrep.2019.01.065. PubMed |
| A20 Orchestrates Inflammatory Response in the Oral Mucosa through Restraining NF-kappaB Activity. Li Y, Mooney EC, Holden SE, Xia XJ, Cohen DJ, Walsh SW, Ma A, Sahingur SE. J Immunol. 2019 Apr 1;202(7):2044-2056. doi: 10.4049/jimmunol.1801286. Epub 2019 Feb 13. PubMed |
| Egr2 overexpression in Schwann cells increases myelination frequency in vitro. Tammia M, Mi R, Sluch VM, Zhu A, Chung T, Shinn D, Zack DJ, Hoke A, Mao HQ. Heliyon. 2018 Nov 29;4(11):e00982. doi: 10.1016/j.heliyon.2018.e00982. eCollection 2018 Nov. PubMed |
| MicroRNA-375 Suppresses the Growth and Invasion of Fibrolamellar Carcinoma. Dinh TA, Jewell ML, Kanke M, Francisco A, Sritharan R, Turnham RE, Lee S, Kastenhuber ER, Wauthier E, Guy CD, Yeung RS, Lowe SW, Reid LM, Scott JD, Diehl AM, Sethupathy P. Cell Mol Gastroenterol Hepatol. 2019;7(4):803-817. doi: 10.1016/j.jcmgh.2019.01.008. Epub 2019 Feb 11. PubMed |
| Heterochromatin anomalies and double-stranded RNA accumulation underlie C9orf72 poly(PR) toxicity. Zhang YJ, Guo L, Gonzales PK, Gendron TF, Wu Y, Jansen-West K, O'Raw AD, Pickles SR, Prudencio M, Carlomagno Y, Gachechiladze MA, Ludwig C, Tian R, Chew J, DeTure M, Lin WL, Tong J, Daughrity LM, Yue M, Song Y, Andersen JW, Castanedes-Casey M, Kurti A, Datta A, Antognetti G, McCampbell A, Rademakers R, Oskarsson B, Dickson DW, Kampmann M, Ward ME, Fryer JD, Link CD, Shorter J, Petrucelli L. Science. 2019 Feb 15;363(6428). pii: 363/6428/eaav2606. doi: 10.1126/science.aav2606. PubMed |
| O-GlcNAc Transferase Suppresses Inflammation and Necroptosis by Targeting Receptor-Interacting Serine/Threonine-Protein Kinase 3. Li X, Gong W, Wang H, Li T, Attri KS, Lewis RE, Kalil AC, Bhinderwala F, Powers R, Yin G, Herring LE, Asara JM, Lei YL, Yang X, Rodriguez DA, Yang M, Green DR, Singh PK, Wen H. Immunity. 2019 Mar 19;50(3):576-590.e6. doi: 10.1016/j.immuni.2019.01.007. Epub 2019 Feb 12. PubMed |
| Bi-allelic Variants in TONSL Cause SPONASTRIME Dysplasia and a Spectrum of Skeletal Dysplasia Phenotypes. Burrage LC, Reynolds JJ, Baratang NV, Phillips JB, Wegner J, McFarquhar A, Higgs MR, Christiansen AE, Lanza DG, Seavitt JR, Jain M, Li X, Parry DA, Raman V, Chitayat D, Chinn IK, Bertuch AA, Karaviti L, Schlesinger AE, Earl D, Bamshad M, Savarirayan R, Doddapaneni H, Muzny D, Jhangiani SN, Eng CM, Gibbs RA, Bi W, Emrick L, Rosenfeld JA, Postlethwait J, Westerfield M, Dickinson ME, Beaudet AL, Ranza E, Huber C, Cormier-Daire V, Shen W, Mao R, Heaney JD, Orange JS, Bertola D, Yamamoto GL, Baratela WAR, Butler MG, Ali A, Adeli M, Cohn DH, Krakow D, Jackson AP, Lees M, Offiah AC, Carlston CM, Carey JC, Stewart GS, Bacino CA, Campeau PM, Lee B. Am J Hum Genet. 2019 Mar 7;104(3):422-438. doi: 10.1016/j.ajhg.2019.01.007. Epub 2019 Feb 14. PubMed |
| Histone Acetyltransferase p300 Induces De Novo Super-Enhancers to Drive Cellular Senescence. Sen P, Lan Y, Li CY, Sidoli S, Donahue G, Dou Z, Frederick B, Chen Q, Luense LJ, Garcia BA, Dang W, Johnson FB, Adams PD, Schultz DC, Berger SL. Mol Cell. 2019 Feb 21;73(4):684-698.e8. doi: 10.1016/j.molcel.2019.01.021. Epub 2019 Feb 14. PubMed |
| ARv7 Represses Tumor-Suppressor Genes in Castration-Resistant Prostate Cancer. Cato L, de Tribolet-Hardy J, Lee I, Rottenberg JT, Coleman I, Melchers D, Houtman R, Xiao T, Li W, Uo T, Sun S, Kuznik NC, Goppert B, Ozgun F, van Royen ME, Houtsmuller AB, Vadhi R, Rao PK, Li L, Balk SP, Den RB, Trock BJ, Karnes RJ, Jenkins RB, Klein EA, Davicioni E, Gruhl FJ, Long HW, Liu XS, Cato ACB, Lack NA, Nelson PS, Plymate SR, Groner AC, Brown M. Cancer Cell. 2019 Mar 18;35(3):401-413.e6. doi: 10.1016/j.ccell.2019.01.008. Epub 2019 Feb 14. PubMed |
| SIRT3 promotes antimycobacterial defenses by coordinating mitochondrial and autophagic functions. Kim TS, Jin YB, Kim YS, Kim S, Kim JK, Lee HM, Suh HW, Choe JH, Kim YJ, Koo BS, Kim HN, Jung M, Lee SH, Kim DK, Chung C, Son JW, Min JJ, Kim JM, Deng CX, Kim HS, Lee SR, Jo EK. Autophagy. 2019 Aug;15(8):1356-1375. doi: 10.1080/15548627.2019.1582743. Epub 2019 Mar 4. PubMed |
| Teneurin C-Terminal Associated Peptide (TCAP)-1 and Latrophilin Interaction in HEK293 Cells: Evidence for Modulation of Intercellular Adhesion. Husic M, Barsyte-Lovejoy D, Lovejoy DA. Front Endocrinol (Lausanne). 2019 Feb 1;10:22. doi: 10.3389/fendo.2019.00022. eCollection 2019. PubMed |
| Anti-silencing function 1B histone chaperone promotes cell proliferation and migration via activation of the AKT pathway in clear cell renal cell carcinoma. Jiangqiao Z, Tao Q, Zhongbao C, Xiaoxiong M, Long Z, Jilin Z, Tianyu W. Biochem Biophys Res Commun. 2019 Mar 26;511(1):165-172. doi: 10.1016/j.bbrc.2019.02.060. Epub 2019 Feb 15. PubMed |
| Metastasis-associated protein 1 (MTA1) is transferred by exosomes and contributes to the regulation of hypoxia and estrogen signaling in breast cancer cells. Hannafon BN, Gin AL, Xu YF, Bruns M, Calloway CL, Ding WQ. Cell Commun Signal. 2019 Feb 19;17(1):13. doi: 10.1186/s12964-019-0325-7. PubMed |
Fibroblast growth factor receptor influences primary cilium length through an interaction with intestinal cell kinase.
Kunova Bosakova M, Nita A, Gregor T, Varecha M, Gudernova I, Fafilek B, Barta T, Basheer N, Abraham SP, Balek L, Tomanova M, Fialova Kucerova J, Bosak J, Potesil D, Zieba J, Song J, Konik P, Park S, Duran I, Zdrahal Z, Smajs D, Jansen G, Fu Z, Ko HW, Hampl A, Trantirek L, Krakow D, Krejci P.
Proc Natl Acad Sci U S A. 2019 Feb 19. pii: 1800338116. doi: 10.1073/pnas.1800338116.
PubMed
Associated Plasmids |
| Production of High-Titer Lentiviral Particles for Stable Genetic Modification of Mammalian Cells. Larcombe MR, Manent J, Chen J, Mishra K, Liu X, Nefzger CM. Methods Mol Biol. 2019;1940:47-61. doi: 10.1007/978-1-4939-9086-3_4. PubMed |
| Identification of Broad-Spectrum Antiviral Compounds by Targeting Viral Entry. Mazzon M, Ortega-Prieto AM, Imrie D, Luft C, Hess L, Czieso S, Grove J, Skelton JK, Farleigh L, Bugert JJ, Wright E, Temperton N, Angell R, Oxenford S, Jacobs M, Ketteler R, Dorner M, Marsh M. Viruses. 2019 Feb 20;11(2). pii: v11020176. doi: 10.3390/v11020176. PubMed |
| A metabolic switch in proteasome inhibitor resistant multiple myeloma ensures higher mitochondrial metabolism, protein folding and sphingomyelin synthesis. Besse L, Besse A, Mendez-Lopez M, Vasickova K, Sedlackova M, Vanhara P, Kraus M, Bader J, Ferreira RB, Castellano RK, Law BK, Driessen C. Haematologica. 2019 Feb 21. pii: haematol.2018.207704. doi: 10.3324/haematol.2018.207704. PubMed |
| Calcium Channel Subunit alpha2delta4 Is Regulated by Early Growth Response 1 and Facilitates Epileptogenesis. van Loo KMJ, Rummel CK, Pitsch J, Muller JA, Bikbaev AF, Martinez-Chavez E, Blaess S, Dietrich D, Heine M, Becker AJ, Schoch S. J Neurosci. 2019 Apr 24;39(17):3175-3187. doi: 10.1523/JNEUROSCI.1731-18.2019. Epub 2019 Feb 21. PubMed |
Pan-Cancer Analyses Reveal Genomic Features of FOXM1 Overexpression in Cancer.
Barger CJ, Branick C, Chee L, Karpf AR.
Cancers (Basel). 2019 Feb 21;11(2). pii: cancers11020251. doi: 10.3390/cancers11020251.
PubMed
Associated Plasmids |
| Protein phosphatase 2A Aalpha regulates Abeta protein expression and stability. O'Connor CM, Hoffa MT, Taylor SE, Avelar RA, Narla G. J Biol Chem. 2019 Apr 12;294(15):5923-5934. doi: 10.1074/jbc.RA119.007593. Epub 2019 Feb 22. PubMed |
| Telomere-dependent and telomere-independent roles of RAP1 in regulating human stem cell homeostasis. Zhang X, Liu Z, Liu X, Wang S, Zhang Y, He X, Sun S, Ma S, Shyh-Chang N, Liu F, Wang Q, Wang X, Liu L, Zhang W, Song M, Liu GH, Qu J. Protein Cell. 2019 Feb 22. pii: 10.1007/s13238-019-0610-7. doi: 10.1007/s13238-019-0610-7. PubMed |
| Targeting an RNA-Binding Protein Network in Acute Myeloid Leukemia. Wang E, Lu SX, Pastore A, Chen X, Imig J, Chun-Wei Lee S, Hockemeyer K, Ghebrechristos YE, Yoshimi A, Inoue D, Ki M, Cho H, Bitner L, Kloetgen A, Lin KT, Uehara T, Owa T, Tibes R, Krainer AR, Abdel-Wahab O, Aifantis I. Cancer Cell. 2019 Mar 18;35(3):369-384.e7. doi: 10.1016/j.ccell.2019.01.010. Epub 2019 Feb 21. PubMed |
| Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion. Harris IS, Endress JE, Coloff JL, Selfors LM, McBrayer SK, Rosenbluth JM, Takahashi N, Dhakal S, Koduri V, Oser MG, Schauer NJ, Doherty LM, Hong AL, Kang YP, Younger ST, Doench JG, Hahn WC, Buhrlage SJ, DeNicola GM, Kaelin WG Jr, Brugge JS. Cell Metab. 2019 May 7;29(5):1166-1181.e6. doi: 10.1016/j.cmet.2019.01.020. Epub 2019 Feb 21. PubMed |
NFIA is a gliogenic switch enabling rapid derivation of functional human astrocytes from pluripotent stem cells.
Tchieu J, Calder EL, Guttikonda SR, Gutzwiller EM, Aromolaran KA, Steinbeck JA, Goldstein PA, Studer L.
Nat Biotechnol. 2019 Mar;37(3):267-275. doi: 10.1038/s41587-019-0035-0. Epub 2019 Feb 25.
PubMed
Associated Plasmids |
| FBXO22 promotes the development of hepatocellular carcinoma by regulating the ubiquitination and degradation of p21. Zhang L, Chen J, Ning D, Liu Q, Wang C, Zhang Z, Chu L, Yu C, Liang HF, Zhang B, Chen X. J Exp Clin Cancer Res. 2019 Feb 26;38(1):101. doi: 10.1186/s13046-019-1058-6. PubMed |
| Highly Purified Human Extracellular Vesicles Produced by Stem Cells Alleviate Aging Cellular Phenotypes of Senescent Human Cells. Liu S, Mahairaki V, Bai H, Ding Z, Li J, Witwer KW, Cheng L. Stem Cells. 2019 Jun;37(6):779-790. doi: 10.1002/stem.2996. Epub 2019 Mar 12. PubMed |
| PRMT5 Modulates Splicing for Genome Integrity and Preserves Proteostasis of Hematopoietic Stem Cells. Tan DQ, Li Y, Yang C, Li J, Tan SH, Chin DWL, Nakamura-Ishizu A, Yang H, Suda T. Cell Rep. 2019 Feb 26;26(9):2316-2328.e6. doi: 10.1016/j.celrep.2019.02.001. PubMed |
| Functional Profiling Identifies Determinants of Arsenic Trioxide Cellular Toxicity. Sobh A, Loguinov A, Yazici GN, Zeidan RS, Tagmount A, Hejazi NS, Hubbard AE, Zhang L, Vulpe CD. Toxicol Sci. 2019 May 1;169(1):108-121. doi: 10.1093/toxsci/kfz024. PubMed |
| Unique properties of PTEN-L contribute to neuroprotection in response to ischemic-like stress. Jochner MCE, An J, Lattig-Tunnemann G, Kirchner M, Dagane A, Dittmar G, Dirnagl U, Eickholt BJ, Harms C. Sci Rep. 2019 Feb 28;9(1):3183. doi: 10.1038/s41598-019-39438-1. PubMed |
| High-resolution characterization of centriole distal appendage morphology and dynamics by correlative STORM and electron microscopy. Bowler M, Kong D, Sun S, Nanjundappa R, Evans L, Farmer V, Holland A, Mahjoub MR, Sui H, Loncarek J. Nat Commun. 2019 Mar 1;10(1):993. doi: 10.1038/s41467-018-08216-4. PubMed |
| The stability of Magoh and Y14 depends on their heterodimer formation and nuclear localization. Ma Q, Tatsuno T, Nakamura Y, Ishigaki Y. Biochem Biophys Res Commun. 2019 Apr 9;511(3):631-636. doi: 10.1016/j.bbrc.2019.02.097. Epub 2019 Feb 27. PubMed |
| A novel L1CAM isoform with angiogenic activity generated by NOVA2-mediated alternative splicing. Angiolini F, Belloni E, Giordano M, Campioni M, Forneris F, Paronetto MP, Lupia M, Brandas C, Pradella D, Di Matteo A, Giampietro C, Jodice G, Luise C, Bertalot G, Freddi S, Malinverno M, Irimia M, Moulton JD, Summerton J, Chiapparino A, Ghilardi C, Giavazzi R, Nyqvist D, Gabellini D, Dejana E, Cavallaro U, Ghigna C. Elife. 2019 Mar 4;8. pii: 44305. doi: 10.7554/eLife.44305. PubMed |
| BETP degradation simultaneously targets acute myelogenous leukemia stem cells and the microenvironment. Piya S, Mu H, Bhattacharya S, Lorenzi PL, Davis RE, McQueen T, Ruvolo V, Baran N, Wang Z, Qian Y, Crews CM, Konopleva M, Ishizawa J, You MJ, Kantarjian H, Andreeff M, Borthakur G. J Clin Invest. 2019 Feb 21;129(5):1878-1894. doi: 10.1172/JCI120654. Print 2019 May 1. PubMed |
| Circular synthesized CRISPR/Cas gRNAs for functional interrogations in the coding and noncoding genome. Wegner M, Diehl V, Bittl V, de Bruyn R, Wiechmann S, Matthess Y, Hebel M, Hayes MG, Schaubeck S, Benner C, Heinz S, Bremm A, Dikic I, Ernst A, Kaulich M. Elife. 2019 Mar 6;8. pii: 42549. doi: 10.7554/eLife.42549. PubMed |
| Human Pluripotent Stem Cell-Derived Tumor Model Uncovers the Embryonic Stem Cell Signature as a Key Driver in Atypical Teratoid/Rhabdoid Tumor. Terada Y, Jo N, Arakawa Y, Sakakura M, Yamada Y, Ukai T, Kabata M, Mitsunaga K, Mineharu Y, Ohta S, Nakagawa M, Miyamoto S, Yamamoto T, Yamada Y. Cell Rep. 2019 Mar 5;26(10):2608-2621.e6. doi: 10.1016/j.celrep.2019.02.009. PubMed |
| Myeloid Folliculin balances mTOR activation to maintain innate immunity homeostasis. Li J, Wada S, Weaver LK, Biswas C, Behrens EM, Arany Z. JCI Insight. 2019 Mar 7;5. pii: 126939. doi: 10.1172/jci.insight.126939. PubMed |
| TZAP plays an inhibitory role in the self-renewal of porcine mesenchymal stromal cells and is implicated the regulation of premature senescence via the p53 pathway. Bie YN, Gu P, Chen YT, Zhou XX, Tian YG, Yang Q, Li HY, Lin X, Guan YH, Lin TY, Lu X, Shen HF, Fang TX, Liu YM, Xiao D, Gu WW. J Transl Med. 2019 Mar 7;17(1):72. doi: 10.1186/s12967-019-1820-8. PubMed |
| Induction of Potent Neutralizing Antibody Responses by a Designed Protein Nanoparticle Vaccine for Respiratory Syncytial Virus. Marcandalli J, Fiala B, Ols S, Perotti M, de van der Schueren W, Snijder J, Hodge E, Benhaim M, Ravichandran R, Carter L, Sheffler W, Brunner L, Lawrenz M, Dubois P, Lanzavecchia A, Sallusto F, Lee KK, Veesler D, Correnti CE, Stewart LJ, Baker D, Lore K, Perez L, King NP. Cell. 2019 Mar 7;176(6):1420-1431.e17. doi: 10.1016/j.cell.2019.01.046. PubMed |
| LAMB3 mediates apoptotic, proliferative, invasive, and metastatic behaviors in pancreatic cancer by regulating the PI3K/Akt signaling pathway. Zhang H, Pan YZ, Cheung M, Cao M, Yu C, Chen L, Zhan L, He ZW, Sun CY. Cell Death Dis. 2019 Mar 8;10(3):230. doi: 10.1038/s41419-019-1320-z. PubMed |
| MAP4K4 Inhibition Promotes Survival of Human Stem Cell-Derived Cardiomyocytes and Reduces Infarct Size In Vivo. Fiedler LR, Chapman K, Xie M, Maifoshie E, Jenkins M, Golforoush PA, Bellahcene M, Noseda M, Faust D, Jarvis A, Newton G, Paiva MA, Harada M, Stuckey DJ, Song W, Habib J, Narasimhan P, Aqil R, Sanmugalingam D, Yan R, Pavanello L, Sano M, Wang SC, Sampson RD, Kanayaganam S, Taffet GE, Michael LH, Entman ML, Tan TH, Harding SE, Low CMR, Tralau-Stewart C, Perrior T, Schneider MD. Cell Stem Cell. 2019 Apr 4;24(4):579-591.e12. doi: 10.1016/j.stem.2019.01.013. Epub 2019 Mar 7. PubMed |
| Kaiso is required for MTG16-dependent effects on colitis-associated carcinoma. Short SP, Barrett CW, Stengel KR, Revetta FL, Choksi YA, Coburn LA, Lintel MK, McDonough EM, Washington MK, Wilson KT, Prokhortchouk E, Chen X, Hiebert SW, Reynolds AB, Williams CS. Oncogene. 2019 Jun;38(25):5091-5106. doi: 10.1038/s41388-019-0777-7. Epub 2019 Mar 11. PubMed |
| Replication Study: The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44. Yan X, Tang B, Chen B, Shan Y, Yang H, Iorns E, Tsui R, Denis A, Perfito N, Errington TM. Elife. 2019 Mar 12;8. pii: 43511. doi: 10.7554/eLife.43511. PubMed |
| Integrin alpha6beta4E variant is associated with actin and CD9 structures and modifies the biophysical properties of cell-cell and cell-extracellular matrix interactions. Wang M, Hinton JP, Gard JMC, Garcia JGN, Knudsen BS, Nagle RB, Cress AE. Mol Biol Cell. 2019 Mar 21;30(7):838-850. doi: 10.1091/mbc.E18-10-0652. Epub 2019 Mar 13. PubMed |
| Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity. Aho ER, Wang J, Gogliotti RD, Howard GC, Phan J, Acharya P, Macdonald JD, Cheng K, Lorey SL, Lu B, Wenzel S, Foshage AM, Alvarado J, Wang F, Shaw JG, Zhao B, Weissmiller AM, Thomas LR, Vakoc CR, Hall MD, Hiebert SW, Liu Q, Stauffer SR, Fesik SW, Tansey WP. Cell Rep. 2019 Mar 12;26(11):2916-2928.e13. doi: 10.1016/j.celrep.2019.02.047. PubMed |
| p53 Promotes Cancer Cell Adaptation to Glutamine Deprivation by Upregulating Slc7a3 to Increase Arginine Uptake. Lowman XH, Hanse EA, Yang Y, Ishak Gabra MB, Tran TQ, Li H, Kong M. Cell Rep. 2019 Mar 12;26(11):3051-3060.e4. doi: 10.1016/j.celrep.2019.02.037. PubMed |
| The lncRNA TP73-AS1 is linked to aggressiveness in glioblastoma and promotes temozolomide resistance in glioblastoma cancer stem cells. Mazor G, Levin L, Picard D, Ahmadov U, Caren H, Borkhardt A, Reifenberger G, Leprivier G, Remke M, Rotblat B. Cell Death Dis. 2019 Mar 13;10(3):246. doi: 10.1038/s41419-019-1477-5. PubMed |
| Quantification of human neuromuscular function through optogenetics. Vila OF, Uzel SGM, Ma SP, Williams D, Pak J, Kamm RD, Vunjak-Novakovic G. Theranostics. 2019 Jan 31;9(5):1232-1246. doi: 10.7150/thno.25735. eCollection 2019. PubMed |
| TFEB-driven lysosomal biogenesis is pivotal for PGC1alpha-dependent renal stress resistance. Lynch MR, Tran MT, Ralto KM, Zsengeller ZK, Raman V, Bhasin SS, Sun N, Chen X, Brown D, Rovira II, Taguchi K, Brooks CR, Stillman IE, Bhasin MK, Finkel T, Parikh SM. JCI Insight. 2019 Mar 14;5. pii: 126749. doi: 10.1172/jci.insight.126749. PubMed |
| Rapid and reversible suppression of ALT by DAXX in osteosarcoma cells. Yost KE, Clatterbuck Soper SF, Walker RL, Pineda MA, Zhu YJ, Ester CD, Showman S, Roschke AV, Waterfall JJ, Meltzer PS. Sci Rep. 2019 Mar 14;9(1):4544. doi: 10.1038/s41598-019-41058-8. PubMed |
| EZH2 Inhibition in Ewing Sarcoma Upregulates GD2 Expression for Targeting with Gene-Modified T Cells. Kailayangiri S, Altvater B, Lesch S, Balbach S, Gottlich C, Kuhnemundt J, Mikesch JH, Schelhaas S, Jamitzky S, Meltzer J, Farwick N, Greune L, Fluegge M, Kerl K, Lode HN, Siebert N, Muller I, Walles H, Hartmann W, Rossig C. Mol Ther. 2019 May 8;27(5):933-946. doi: 10.1016/j.ymthe.2019.02.014. Epub 2019 Feb 23. PubMed |
Single-Cell Proteomics Reveal that Quantitative Changes in Co-expressed Lineage-Specific Transcription Factors Determine Cell Fate.
Palii CG, Cheng Q, Gillespie MA, Shannon P, Mazurczyk M, Napolitani G, Price ND, Ranish JA, Morrissey E, Higgs DR, Brand M.
Cell Stem Cell. 2019 May 2;24(5):812-820.e5. doi: 10.1016/j.stem.2019.02.006. Epub 2019 Mar 14.
PubMed
Associated Plasmids |
| Optimization of lentiviral transduction parameters and its application for CRISPR-based secretome modification of human endometrial mesenchymal stem cells. Deryabin P, Griukova A, Shatrova A, Petukhov A, Nikolsky N, Borodkina A. Cell Cycle. 2019 Mar - Apr;18(6-7):742-758. doi: 10.1080/15384101.2019.1593650. Epub 2019 Mar 28. PubMed |
| The TLR4 adaptor TRAM controls the phagocytosis of Gram-negative bacteria by interacting with the Rab11-family interacting protein 2. Skjesol A, Yurchenko M, Bosl K, Gravastrand C, Nilsen KE, Grovdal LM, Agliano F, Patane F, Lentini G, Kim H, Teti G, Kumar Sharma A, Kandasamy RK, Sporsheim B, Starheim KK, Golenbock DT, Stenmark H, McCaffrey M, Espevik T, Husebye H. PLoS Pathog. 2019 Mar 18;15(3):e1007684. doi: 10.1371/journal.ppat.1007684. eCollection 2019 Mar. PubMed |
| Logic-Gated ROR1 Chimeric Antigen Receptor Expression Rescues T Cell-Mediated Toxicity to Normal Tissues and Enables Selective Tumor Targeting. Srivastava S, Salter AI, Liggitt D, Yechan-Gunja S, Sarvothama M, Cooper K, Smythe KS, Dudakov JA, Pierce RH, Rader C, Riddell SR. Cancer Cell. 2019 Mar 18;35(3):489-503.e8. doi: 10.1016/j.ccell.2019.02.003. PubMed |
| DNA Replication Vulnerabilities Render Ovarian Cancer Cells Sensitive to Poly(ADP-Ribose) Glycohydrolase Inhibitors. Pillay N, Tighe A, Nelson L, Littler S, Coulson-Gilmer C, Bah N, Golder A, Bakker B, Spierings DCJ, James DI, Smith KM, Jordan AM, Morgan RD, Ogilvie DJ, Foijer F, Jackson DA, Taylor SS. Cancer Cell. 2019 Mar 18;35(3):519-533.e8. doi: 10.1016/j.ccell.2019.02.004. PubMed |
| Chronic optogenetic induction of stress granules is cytotoxic and reveals the evolution of ALS-FTD pathology. Zhang P, Fan B, Yang P, Temirov J, Messing J, Kim HJ, Taylor JP. Elife. 2019 Mar 20;8. pii: 39578. doi: 10.7554/eLife.39578. PubMed |
| Autaptic cultures of human induced neurons as a versatile platform for studying synaptic function and neuronal morphology. Fenske P, Grauel MK, Brockmann MM, Dorrn AL, Trimbuch T, Rosenmund C. Sci Rep. 2019 Mar 20;9(1):4890. doi: 10.1038/s41598-019-41259-1. PubMed |
| Genome-wide CRISPR screen reveals PSMA6 to be an essential gene in pancreatic cancer cells. Bakke J, Wright WC, Zamora AE, Oladimeji P, Crawford JC, Brewer CT, Autry RJ, Evans WE, Thomas PG, Chen T. BMC Cancer. 2019 Mar 21;19(1):253. doi: 10.1186/s12885-019-5455-1. PubMed |
Induced Neurons for the Study of Neurodegenerative and Neurodevelopmental Disorders.
Sauter EJ, Kutsche LK, Klapper SD, Busskamp V.
Methods Mol Biol. 2019;1942:101-121. doi: 10.1007/978-1-4939-9080-1_9.
PubMed
Associated Plasmids |
| Characterization of the ERG-regulated Kinome in Prostate Cancer Identifies TNIK as a Potential Therapeutic Target. Lee RS, Zhang L, Berger A, Lawrence MG, Song J, Niranjan B, Davies RG, Lister NL, Sandhu SK, Rubin MA, Risbridger GP, Taylor RA, Rickman DS, Horvath LG, Daly RJ. Neoplasia. 2019 Apr;21(4):389-400. doi: 10.1016/j.neo.2019.02.005. Epub 2019 Mar 20. PubMed |
| WNT3a and WNT5a Transported by Exosomes Activate WNT Signaling Pathways in Human Cardiac Fibroblasts. Dzialo E, Rudnik M, Koning RI, Czepiel M, Tkacz K, Baj-Krzyworzeka M, Distler O, Siedlar M, Kania G, Blyszczuk P. Int J Mol Sci. 2019 Mar 21;20(6). pii: ijms20061436. doi: 10.3390/ijms20061436. PubMed |
| Elevated Heme Synthesis and Uptake Underpin Intensified Oxidative Metabolism and Tumorigenic Functions in Non-Small Cell Lung Cancer Cells. Sohoni S, Ghosh P, Wang T, Kalainayakan SP, Vidal C, Dey S, Konduri PC, Zhang L. Cancer Res. 2019 May 15;79(10):2511-2525. doi: 10.1158/0008-5472.CAN-18-2156. Epub 2019 Mar 22. PubMed |
| Substrate mechanics controls adipogenesis through YAP phosphorylation by dictating cell spreading. Oliver-De La Cruz J, Nardone G, Vrbsky J, Pompeiano A, Perestrelo AR, Capradossi F, Melajova K, Filipensky P, Forte G. Biomaterials. 2019 Jun;205:64-80. doi: 10.1016/j.biomaterials.2019.03.009. Epub 2019 Mar 16. PubMed |
| Cut-and-Run: A Distinct Mechanism by which V(D)J Recombination Causes Genome Instability. Kirkham CM, Scott JNF, Wang X, Smith AL, Kupinski AP, Ford AM, Westhead DR, Stockley PG, Tuma R, Boyes J. Mol Cell. 2019 May 2;74(3):584-597.e9. doi: 10.1016/j.molcel.2019.02.025. Epub 2019 Mar 21. PubMed |
| Exome Sequencing of ABCB5 Identifies Recurrent Melanoma Mutations that Result in Increased Proliferative and Invasive Capacities. Sana G, Madigan JP, Gartner JJ, Fourrez M, Lin J, Qutob N, Narayan J, Shukla S, Ambudkar SV, Xia D, Rosenberg SA, Gottesman MM, Samuels Y, Gillet JP. J Invest Dermatol. 2019 Mar 21. pii: S0022-202X(19)31330-2. doi: 10.1016/j.jid.2019.01.036. PubMed |
| miR-338-3p regulates the proliferation, apoptosis and migration of SW480 cells by targeting MACC1. Lu M, Huang H, Yang J, Li J, Zhao G, Li W, Li X, Liu G, Wei L, Shi B, Zhao C, Fu Y. Exp Ther Med. 2019 Apr;17(4):2807-2814. doi: 10.3892/etm.2019.7260. Epub 2019 Feb 12. PubMed |
| Loss of TP63 Promotes the Metastasis of Head and Neck Squamous Cell Carcinoma by Activating MAPK and STAT3 Signaling. Lakshmanachetty S, Balaiya V, High WA, Koster MI. Mol Cancer Res. 2019 Jun;17(6):1279-1293. doi: 10.1158/1541-7786.MCR-18-1355. Epub 2019 Mar 25. PubMed |
| Production and Validation of Lentiviral Vectors for CRISPR/Cas9 Delivery. Ryo LB, Thomsen EA, Mikkelsen JG. Methods Mol Biol. 2019;1961:93-109. doi: 10.1007/978-1-4939-9170-9_7. PubMed |
| Maintenance of Nucleolar Homeostasis by CBX4 Alleviates Senescence and Osteoarthritis. Ren X, Hu B, Song M, Ding Z, Dang Y, Liu Z, Zhang W, Ji Q, Ren R, Ding J, Chan P, Jiang C, Ye K, Qu J, Tang F, Liu GH. Cell Rep. 2019 Mar 26;26(13):3643-3656.e7. doi: 10.1016/j.celrep.2019.02.088. PubMed |
| Atheroprotective Flow Upregulates ITPR3 (Inositol 1,4,5-Trisphosphate Receptor 3) in Vascular Endothelium via KLF4 (Kruppel-Like Factor 4)-Mediated Histone Modifications. He M, Huang TS, Li S, Hong HC, Chen Z, Martin M, Zhou X, Huang HY, Su SH, Zhang J, Wang WT, Kang J, Huang HD, Zhang J, Chien S, Shyy JY. Arterioscler Thromb Vasc Biol. 2019 May;39(5):902-914. doi: 10.1161/ATVBAHA.118.312301. PubMed |
| Combined Transcriptome and Proteome Analysis of Immortalized Human Keratinocytes Expressing Human Papillomavirus 16 (HPV16) Oncogenes Reveals Novel Key Factors and Networks in HPV-Induced Carcinogenesis. Yang R, Klimentova J, Gockel-Krzikalla E, Ly R, Gmelin N, Hotz-Wagenblatt A, Rehulkova H, Stulik J, Rosl F, Niebler M. mSphere. 2019 Mar 27;4(2). pii: 4/2/e00129-19. doi: 10.1128/mSphere.00129-19. PubMed |
| Syndecan 1 is a critical mediator of macropinocytosis in pancreatic cancer. Yao W, Rose JL, Wang W, Seth S, Jiang H, Taguchi A, Liu J, Yan L, Kapoor A, Hou P, Chen Z, Wang Q, Nezi L, Xu Z, Yao J, Hu B, Pettazzoni PF, Ho IL, Feng N, Ramamoorthy V, Jiang S, Deng P, Ma GJ, Den P, Tan Z, Zhang SX, Wang H, Wang YA, Deem AK, Fleming JB, Carugo A, Heffernan TP, Maitra A, Viale A, Ying H, Hanash S, DePinho RA, Draetta GF. Nature. 2019 Apr;568(7752):410-414. doi: 10.1038/s41586-019-1062-1. Epub 2019 Mar 27. PubMed |
| Chemokine (C-X-C motif) ligand 14 contributes to lipopolysaccharide-induced fibrogenesis in mouse L929 fibroblasts via modulating PPM1A. Li L, Li Q, Wei L, Wang Z, Ma W, Liu F, Shen Y, Zhang S, Zhang X, Li H, Qian Y. J Cell Biochem. 2019 Aug;120(8):13372-13381. doi: 10.1002/jcb.28612. Epub 2019 Mar 28. PubMed |
| Sex determining region Y-box 12 (SOX12) promotes gastric cancer metastasis by upregulating MMP7 and IGF1. Du F, Feng W, Chen S, Wu S, Cao T, Yuan T, Tian D, Nie Y, Wu K, Fan D, Xia L. Cancer Lett. 2019 Jun 28;452:103-118. doi: 10.1016/j.canlet.2019.03.035. Epub 2019 Mar 25. PubMed |
| Tacalcitol increases the sensitivity of colorectal cancer cells to 5-fluorouracil by downregulating the thymidylate synthase. Milczarek M, Rossowska J, Klopotowska D, Stachowicz M, Kutner A, Wietrzyk J. J Steroid Biochem Mol Biol. 2019 Jun;190:139-151. doi: 10.1016/j.jsbmb.2019.03.017. Epub 2019 Mar 25. PubMed |
| The long noncoding RNA Falcor regulates Foxa2 expression to maintain lung epithelial homeostasis and promote regeneration. Swarr DT, Herriges M, Li S, Morley M, Fernandes S, Sridharan A, Zhou S, Garcia BA, Stewart K, Morrisey EE. Genes Dev. 2019 Jun 1;33(11-12):656-668. doi: 10.1101/gad.320523.118. Epub 2019 Mar 28. PubMed |
| The homophilic receptor PTPRK selectively dephosphorylates multiple junctional regulators to promote cell-cell adhesion. Fearnley GW, Young KA, Edgar JR, Antrobus R, Hay IM, Liang WC, Martinez-Martin N, Lin W, Deane JE, Sharpe HJ. Elife. 2019 Mar 29;8. pii: 44597. doi: 10.7554/eLife.44597. PubMed |
| Progesterone receptor isoform B expression in pulmonary neuroendocrine cells decreases cell proliferation. Asavasupreechar T, Saito R, Edwards DP, Sasano H, Boonyaratanakornkit V. J Steroid Biochem Mol Biol. 2019 Jun;190:212-223. doi: 10.1016/j.jsbmb.2019.03.022. Epub 2019 Mar 26. PubMed |
| The kinase PERK and the transcription factor ATF4 play distinct and essential roles in autophagy resulting from tunicamycin-induced ER stress. Luhr M, Torgersen ML, Szalai P, Hashim A, Brech A, Staerk J, Engedal N. J Biol Chem. 2019 May 17;294(20):8197-8217. doi: 10.1074/jbc.RA118.002829. Epub 2019 Mar 29. PubMed |
| Safe and neuroprotective vectors for long-term traumatic brain injury gene therapy. Blanco-Ocampo D, Cawen FA, Alamo-Pindado LA, Negro-Demontel ML, Peluffo H. Gene Ther. 2019 Mar 29. pii: 10.1038/s41434-019-0073-8. doi: 10.1038/s41434-019-0073-8. PubMed |
| MYC Recruits SPT5 to RNA Polymerase II to Promote Processive Transcription Elongation. Baluapuri A, Hofstetter J, Dudvarski Stankovic N, Endres T, Bhandare P, Vos SM, Adhikari B, Schwarz JD, Narain A, Vogt M, Wang SY, Duster R, Jung LA, Vanselow JT, Wiegering A, Geyer M, Maric HM, Gallant P, Walz S, Schlosser A, Cramer P, Eilers M, Wolf E. Mol Cell. 2019 May 16;74(4):674-687.e11. doi: 10.1016/j.molcel.2019.02.031. Epub 2019 Mar 27. PubMed |
| A Subset of TREM2(+) Dermal Macrophages Secretes Oncostatin M to Maintain Hair Follicle Stem Cell Quiescence and Inhibit Hair Growth. Wang ECE, Dai Z, Ferrante AW, Drake CG, Christiano AM. Cell Stem Cell. 2019 Apr 4;24(4):654-669.e6. doi: 10.1016/j.stem.2019.01.011. Epub 2019 Mar 28. PubMed |
| Up-regulation of FOXD1 by YAP alleviates senescence and osteoarthritis. Fu L, Hu Y, Song M, Liu Z, Zhang W, Yu FX, Wu J, Wang S, Izpisua Belmonte JC, Chan P, Qu J, Tang F, Liu GH. PLoS Biol. 2019 Apr 1;17(4):e3000201. doi: 10.1371/journal.pbio.3000201. eCollection 2019 Apr. PubMed |
| Transcriptional Circuit Fragility Influences HIV Proviral Fate. Morton EL, Forst CV, Zheng Y, DePaula-Silva AB, Ramirez NP, Planelles V, D'Orso I. Cell Rep. 2019 Apr 2;27(1):154-171.e9. doi: 10.1016/j.celrep.2019.03.007. PubMed |
| ADAR2 mislocalization and widespread RNA editing aberrations in C9orf72-mediated ALS/FTD. Moore S, Alsop E, Lorenzini I, Starr A, Rabichow BE, Mendez E, Levy JL, Burciu C, Reiman R, Chew J, Belzil VV, W Dickson D, Robertson J, Staats KA, Ichida JK, Petrucelli L, Van Keuren-Jensen K, Sattler R. Acta Neuropathol. 2019 Jul;138(1):49-65. doi: 10.1007/s00401-019-01999-w. Epub 2019 Apr 3. PubMed |
| Silencing an insulin-induced lncRNA, LncASIR, impairs the transcriptional response to insulin signalling in adipocytes. Degirmenci U, Li J, Lim YC, Siang DTC, Lin S, Liang H, Sun L. Sci Rep. 2019 Apr 4;9(1):5608. doi: 10.1038/s41598-019-42162-5. PubMed |
| Yin Yang 1 Orchestrates a Metabolic Program Required for Both Neural Crest Development and Melanoma Formation. Varum S, Baggiolini A, Zurkirchen L, Atak ZK, Cantu C, Marzorati E, Bossart R, Wouters J, Hausel J, Tuncer E, Zingg D, Veen D, John N, Balz M, Levesque MP, Basler K, Aerts S, Zamboni N, Dummer R, Sommer L. Cell Stem Cell. 2019 Apr 4;24(4):637-653.e9. doi: 10.1016/j.stem.2019.03.011. PubMed |
| Depletion of PD-1-positive cells ameliorates autoimmune disease. Zhao P, Wang P, Dong S, Zhou Z, Cao Y, Yagita H, He X, Zheng SG, Fisher SJ, Fujinami RS, Chen M. Nat Biomed Eng. 2019 Apr;3(4):292-305. doi: 10.1038/s41551-019-0360-0. Epub 2019 Mar 4. PubMed |
| Transmembrane 4 L Six Family Member 5 Senses Arginine for mTORC1 Signaling. Jung JW, Macalino SJY, Cui M, Kim JE, Kim HJ, Song DG, Nam SH, Kim S, Choi S, Lee JW. Cell Metab. 2019 Jun 4;29(6):1306-1319.e7. doi: 10.1016/j.cmet.2019.03.005. Epub 2019 Apr 4. PubMed |
A Synthetic Gene Circuit for Self-Regulating Delivery of Biologic Drugs in Engineered Tissues.
Pferdehirt L, Ross AK, Brunger JM, Guilak F.
Tissue Eng Part A. 2019 May;25(9-10):809-820. doi: 10.1089/ten.TEA.2019.0027.
PubMed
Associated Plasmids |
Essential Gene Profiles for Human Pluripotent Stem Cells Identify Uncharacterized Genes and Substrate Dependencies.
Mair B, Tomic J, Masud SN, Tonge P, Weiss A, Usaj M, Tong AHY, Kwan JJ, Brown KR, Titus E, Atkins M, Chan KSK, Munsie L, Habsid A, Han H, Kennedy M, Cohen B, Keller G, Moffat J.
Cell Rep. 2019 Apr 9;27(2):599-615.e12. doi: 10.1016/j.celrep.2019.02.041.
PubMed
Associated Plasmids |
| Thrombospondin Type 1 Domain-Containing 7A Localizes to the Slit Diaphragm and Stabilizes Membrane Dynamics of Fully Differentiated Podocytes. Herwig J, Skuza S, Sachs W, Sachs M, Failla AV, Rune G, Meyer TN, Fester L, Meyer-Schwesinger C. J Am Soc Nephrol. 2019 May;30(5):824-839. doi: 10.1681/ASN.2018090941. Epub 2019 Apr 10. PubMed |
| Lung cancer deficient in the tumor suppressor GATA4 is sensitive to TGFBR1 inhibition. Gao L, Hu Y, Tian Y, Fan Z, Wang K, Li H, Zhou Q, Zeng G, Hu X, Yu L, Zhou S, Tong X, Huang H, Chen H, Liu Q, Liu W, Zhang G, Zeng M, Zhou G, He Q, Ji H, Chen L. Nat Commun. 2019 Apr 10;10(1):1665. doi: 10.1038/s41467-019-09295-7. PubMed |
| Epigenetic and therapeutic implications of dnmt3b in temporomandibular joint osteoarthritis. Zhou Y, Chen M, O'Keefe RJ, Shen J, Li Z, Zhou J, Zhou X, Mao JJ. Am J Transl Res. 2019 Mar 15;11(3):1736-1747. eCollection 2019. PubMed |
| Development of a Synthetic 3-ketosteroid Delta(1)-dehydrogenase for the Generation of a Novel Catabolic Pathway Enabling Cholesterol Degradation in Human Cells. D'Arcy BM, Swingle MR, Schambeau L, Pannell L, Prakash A, Honkanen RE. Sci Rep. 2019 Apr 12;9(1):5969. doi: 10.1038/s41598-019-42046-8. PubMed |
| Crumbs3 is a critical factor that regulates invasion and metastasis of colon adenocarcinoma via the specific interaction with FGFR1. Iioka H, Saito K, Sakaguchi M, Tachibana T, Homma K, Kondo E. Int J Cancer. 2019 Apr 13. doi: 10.1002/ijc.32336. PubMed |
| RAB27B-activated secretion of stem-like tumor exosomes delivers the biomarker microRNA-146a-5p, which promotes tumorigenesis and associates with an immunosuppressive tumor microenvironment in colorectal cancer. Cheng WC, Liao TT, Lin CC, Yuan LE, Lan HY, Lin HH, Teng HW, Chang HC, Lin CH, Yang CY, Huang SC, Jiang JK, Yang SH, Yang MH, Hwang WL. Int J Cancer. 2019 Apr 13. doi: 10.1002/ijc.32338. PubMed |
| CEA expression heterogeneity and plasticity confer resistance to the CEA-targeting bispecific immunotherapy antibody cibisatamab (CEA-TCB) in patient-derived colorectal cancer organoids. Gonzalez-Exposito R, Semiannikova M, Griffiths B, Khan K, Barber LJ, Woolston A, Spain G, von Loga K, Challoner B, Patel R, Ranes M, Swain A, Thomas J, Bryant A, Saffery C, Fotiadis N, Guettler S, Mansfield D, Melcher A, Powles T, Rao S, Watkins D, Chau I, Matthews N, Wallberg F, Starling N, Cunningham D, Gerlinger M. J Immunother Cancer. 2019 Apr 15;7(1):101. doi: 10.1186/s40425-019-0575-3. PubMed |
| Human Pluripotency Is Initiated and Preserved by a Unique Subset of Founder Cells. Nakanishi M, Mitchell RR, Benoit YD, Orlando L, Reid JC, Shimada K, Davidson KC, Shapovalova Z, Collins TJ, Nagy A, Bhatia M. Cell. 2019 May 2;177(4):910-924.e22. doi: 10.1016/j.cell.2019.03.013. Epub 2019 Apr 11. PubMed |
| Loss of Sirtuin 1 Alters the Secretome of Breast Cancer Cells by Impairing Lysosomal Integrity. Latifkar A, Ling L, Hingorani A, Johansen E, Clement A, Zhang X, Hartman J, Fischbach C, Lin H, Cerione RA, Antonyak MA. Dev Cell. 2019 May 6;49(3):393-408.e7. doi: 10.1016/j.devcel.2019.03.011. Epub 2019 Apr 11. PubMed |
| Lentiviral Vector Platform for the Efficient Delivery of Epigenome-editing Tools into Human Induced Pluripotent Stem Cell-derived Disease Models. Tagliafierro L, Ilich E, Moncalvo M, Gu J, Sriskanda A, Grenier C, Murphy SK, Chiba-Falek O, Kantor B. J Vis Exp. 2019 Mar 29;(145). doi: 10.3791/59241. PubMed |
| HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries. Luo H, Sobh A, Vulpe CD, Brewer E, Dovat S, Qiu Y, Huang S. J Vis Exp. 2019 Mar 31;(145). doi: 10.3791/59382. PubMed |
| Establishment of an erythroid progenitor cell line capable of enucleation achieved with an inducible c-Myc vector. Mayers S, Moco PD, Maqbool T, Silva PN, Kilkenny DM, Audet J. BMC Biotechnol. 2019 Apr 15;19(1):21. doi: 10.1186/s12896-019-0515-9. PubMed |
| CCL5 promotes breast cancer recurrence through macrophage recruitment in residual tumors. Walens A, DiMarco AV, Lupo R, Kroger BR, Damrauer JS, Alvarez JV. Elife. 2019 Apr 16;8. pii: 43653. doi: 10.7554/eLife.43653. PubMed |
| gamma-Catenin-Dependent Signals Maintain BCR-ABL1(+) B Cell Acute Lymphoblastic Leukemia. Luong-Gardiol N, Siddiqui I, Pizzitola I, Jeevan-Raj B, Charmoy M, Huang Y, Irmisch A, Curtet S, Angelov GS, Danilo M, Juilland M, Bornhauser B, Thome M, Hantschel O, Chalandon Y, Cazzaniga G, Bourquin JP, Huelsken J, Held W. Cancer Cell. 2019 Apr 15;35(4):649-663.e10. doi: 10.1016/j.ccell.2019.03.005. PubMed |
| Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia. Huang Y, Su R, Sheng Y, Dong L, Dong Z, Xu H, Ni T, Zhang ZS, Zhang T, Li C, Han L, Zhu Z, Lian F, Wei J, Deng Q, Wang Y, Wunderlich M, Gao Z, Pan G, Zhong D, Zhou H, Zhang N, Gan J, Jiang H, Mulloy JC, Qian Z, Chen J, Yang CG. Cancer Cell. 2019 Apr 15;35(4):677-691.e10. doi: 10.1016/j.ccell.2019.03.006. PubMed |
| The Influenza A Virus Endoribonuclease PA-X Usurps Host mRNA Processing Machinery to Limit Host Gene Expression. Gaucherand L, Porter BK, Levene RE, Price EL, Schmaling SK, Rycroft CH, Kevorkian Y, McCormick C, Khaperskyy DA, Gaglia MM. Cell Rep. 2019 Apr 16;27(3):776-792.e7. doi: 10.1016/j.celrep.2019.03.063. PubMed |
| KLF4 activates NFkappaB signaling and esophageal epithelial inflammation via the Rho-related GTP-binding protein RHOF. Shaverdashvili K, Padlo J, Weinblatt D, Jia Y, Jiang W, Rao D, Laczko D, Whelan KA, Lynch JP, Muir AB, Katz JP. PLoS One. 2019 Apr 18;14(4):e0215746. doi: 10.1371/journal.pone.0215746. eCollection 2019. PubMed |
| Cotargeting of BCL2 with Venetoclax and MCL1 with S63845 Is Synthetically Lethal In Vivo in Relapsed Mantle Cell Lymphoma. Prukova D, Andera L, Nahacka Z, Karolova J, Svaton M, Klanova M, Havranek O, Soukup J, Svobodova K, Zemanova Z, Tuskova D, Pokorna E, Helman K, Forsterova K, Pacheco-Blanco M, Vockova P, Berkova A, Fronkova E, Trneny M, Klener P. Clin Cancer Res. 2019 Jul 15;25(14):4455-4465. doi: 10.1158/1078-0432.CCR-18-3275. Epub 2019 Apr 19. PubMed |
| miR-128 Restriction of LINE-1 (L1) Retrotransposition Is Dependent on Targeting hnRNPA1 mRNA. Fung L, Guzman H, Sevrioukov E, Idica A, Park E, Bochnakian A, Daugaard I, Jury D, Mortazavi A, Zisoulis DG, Pedersen IM. Int J Mol Sci. 2019 Apr 21;20(8). pii: ijms20081955. doi: 10.3390/ijms20081955. PubMed |
| Systematic proteomics of endogenous human cohesin reveals an interaction with diverse splicing factors and RNA-binding proteins required for mitotic progression. Kim JS, He X, Liu J, Duan Z, Kim T, Gerard J, Kim B, Pillai MM, Lane WS, Noble WS, Budnik B, Waldman T. J Biol Chem. 2019 May 31;294(22):8760-8772. doi: 10.1074/jbc.RA119.007832. Epub 2019 Apr 22. PubMed |
| A novel retroviral vector system to analyze expression from mRNA with retained introns using fluorescent proteins and flow cytometry. Jackson PEH, Huang J, Sharma M, Rasmussen SK, Hammarskjold ML, Rekosh D. Sci Rep. 2019 Apr 23;9(1):6467. doi: 10.1038/s41598-019-42914-3. PubMed |
| Insulin Induces Microtubule Stabilization and Regulates the Microtubule Plus-end Tracking Protein Network in Adipocytes. Parker SS, Krantz J, Kwak EA, Barker NK, Deer CG, Lee NY, Mouneimne G, Langlais PR. Mol Cell Proteomics. 2019 Jul;18(7):1363-1381. doi: 10.1074/mcp.RA119.001450. Epub 2019 Apr 24. PubMed |
| JUND regulates pancreatic beta cell survival during metabolic stress. Good AL, Cannon CE, Haemmerle MW, Yang J, Stanescu DE, Doliba NM, Birnbaum MJ, Stoffers DA. Mol Metab. 2019 Jul;25:95-106. doi: 10.1016/j.molmet.2019.04.007. Epub 2019 Apr 11. PubMed |
| Chemical suppression of specific C-C chemokine signaling pathways enhances cardiac reprogramming. Guo Y, Lei I, Tian S, Gao W, Hacer K, Li Y, Wang S, Liu L, Wang Z. J Biol Chem. 2019 Jun 7;294(23):9134-9146. doi: 10.1074/jbc.RA118.006000. Epub 2019 Apr 25. PubMed |
| Optogenetic Monitoring of the Glutathione Redox State in Engineered Human Myocardium. Trautsch I, Heta E, Soong PL, Levent E, Nikolaev VO, Bogeski I, Katschinski DM, Mayr M, Zimmermann WH. Front Physiol. 2019 Apr 4;10:272. doi: 10.3389/fphys.2019.00272. eCollection 2019. PubMed |
| CRISPR Activation Enhances In Vitro Potency of AAV Vectors Driven by Tissue-Specific Promoters. McDougald DS, Duong TT, Palozola KC, Marsh A, Papp TE, Mills JA, Zhou S, Bennett J. Mol Ther Methods Clin Dev. 2019 Mar 28;13:380-389. doi: 10.1016/j.omtm.2019.03.004. eCollection 2019 Jun 14. PubMed |
| CRISPR/Cas9-generated mouse model of Duchenne muscular dystrophy recapitulating a newly identified large 430 kb deletion in the human DMD gene. Egorova TV, Zotova ED, Reshetov DA, Polikarpova AV, Vassilieva SG, Vlodavets DV, Gavrilov AA, Ulianov SV, Buchman VL, Deykin AV. Dis Model Mech. 2019 Apr 25;12(4). pii: 12/4/dmm037655. doi: 10.1242/dmm.037655. PubMed |
| FKBP12 mediates necroptosis by initiating RIPK1-RIPK3-MLKL signal transduction in response to TNF receptor 1 ligation. Wang Z, Feng J, Yu J, Chen G. J Cell Sci. 2019 May 20;132(10). pii: jcs.227777. doi: 10.1242/jcs.227777. PubMed |
| GemC1 governs multiciliogenesis through direct interaction with and transcriptional regulation of p73. Lalioti ME, Arbi M, Loukas I, Kaplani K, Kalogeropoulou A, Lokka G, Kyrousi C, Mizi A, Georgomanolis T, Josipovic N, Gkikas D, Benes V, Politis PK, Papantonis A, Lygerou Z, Taraviras S. J Cell Sci. 2019 Jun 3;132(11). pii: jcs.228684. doi: 10.1242/jcs.228684. PubMed |
| CRISPR Screening in Single Cells. Henriksson J. Methods Mol Biol. 2019;1979:395-406. doi: 10.1007/978-1-4939-9240-9_23. PubMed |
Hypoxia Rescues Frataxin Loss by Restoring Iron Sulfur Cluster Biogenesis.
Ast T, Meisel JD, Patra S, Wang H, Grange RMH, Kim SH, Calvo SE, Orefice LL, Nagashima F, Ichinose F, Zapol WM, Ruvkun G, Barondeau DP, Mootha VK.
Cell. 2019 May 30;177(6):1507-1521.e16. doi: 10.1016/j.cell.2019.03.045. Epub 2019 Apr 25.
PubMed
Associated Plasmids |
| METTL1 Promotes let-7 MicroRNA Processing via m7G Methylation. Pandolfini L, Barbieri I, Bannister AJ, Hendrick A, Andrews B, Webster N, Murat P, Mach P, Brandi R, Robson SC, Migliori V, Alendar A, d'Onofrio M, Balasubramanian S, Kouzarides T. Mol Cell. 2019 Jun 20;74(6):1278-1290.e9. doi: 10.1016/j.molcel.2019.03.040. Epub 2019 Apr 25. PubMed |
| Case Study: Mechanism for Increased Follicular Helper T Cell Development in Activated PI3K Delta Syndrome. Thauland TJ, Pellerin L, Ohgami RS, Bacchetta R, Butte MJ. Front Immunol. 2019 Apr 12;10:753. doi: 10.3389/fimmu.2019.00753. eCollection 2019. PubMed |
| Epigenetic regulation of mammalian Hedgehog signaling to the stroma determines the molecular subtype of bladder cancer. Kim S, Kim Y, Kong J, Kim E, Choi JH, Yuk HD, Lee H, Kim HR, Lee KH, Kang M, Roe JS, Moon KC, Kim S, Ku JH, Shin K. Elife. 2019 Apr 30;8. pii: 43024. doi: 10.7554/eLife.43024. PubMed |
| Influence of SHH/GLI1 axis on EMT mediated migration and invasion of breast cancer cells. Riaz SK, Ke Y, Wang F, Kayani MA, Malik MFA. Sci Rep. 2019 Apr 29;9(1):6620. doi: 10.1038/s41598-019-43093-x. PubMed |
| MRPS25 mutations impair mitochondrial translation and cause encephalomyopathy. Bugiardini E, Mitchell AL, Rosa ID, Horning-Do HT, Pitmann A, Poole OV, Holton JL, Shah S, Woodward C, Hargreaves I, Quinlivan R, Amunts A, Wiesner RJ, Houlden H, Holt IJ, Hanna MG, Pitceathly RDS, Spinazzola A. Hum Mol Genet. 2019 Apr 30. pii: 5482278. doi: 10.1093/hmg/ddz093. PubMed |
| Lysosomal proteome analysis reveals that CLN3-defective cells have multiple enzyme deficiencies associated with changes in intracellular trafficking. Schmidtke C, Tiede S, Thelen M, Kakela R, Jabs S, Makrypidi G, Sylvester M, Schweizer M, Braren I, Brocke-Ahmadinejad N, Cotman SL, Schulz A, Gieselmann V, Braulke T. J Biol Chem. 2019 Jun 14;294(24):9592-9604. doi: 10.1074/jbc.RA119.008852. Epub 2019 Apr 30. PubMed |
| CD13 tethers the IQGAP1-ARF6-EFA6 complex to the plasma membrane to promote ARF6 activation, beta1 integrin recycling, and cell migration. Ghosh M, Lo R, Ivic I, Aguilera B, Qendro V, Devarakonda C, Shapiro LH. Sci Signal. 2019 Apr 30;12(579). pii: 12/579/eaav5938. doi: 10.1126/scisignal.aav5938. PubMed |
| Inhibition of MYC by the SMARCB1 tumor suppressor. Weissmiller AM, Wang J, Lorey SL, Howard GC, Martinez E, Liu Q, Tansey WP. Nat Commun. 2019 May 1;10(1):2014. doi: 10.1038/s41467-019-10022-5. PubMed |
| Mitochondrial ClpP-Mediated Proteolysis Induces Selective Cancer Cell Lethality. Ishizawa J, Zarabi SF, Davis RE, Halgas O, Nii T, Jitkova Y, Zhao R, St-Germain J, Heese LE, Egan G, Ruvolo VR, Barghout SH, Nishida Y, Hurren R, Ma W, Gronda M, Link T, Wong K, Mabanglo M, Kojima K, Borthakur G, MacLean N, Ma MCJ, Leber AB, Minden MD, Houry W, Kantarjian H, Stogniew M, Raught B, Pai EF, Schimmer AD, Andreeff M. Cancer Cell. 2019 May 13;35(5):721-737.e9. doi: 10.1016/j.ccell.2019.03.014. Epub 2019 May 2. PubMed |
| Chemoproteomic Profiling Uncovers CDK4-Mediated Phosphorylation of the Translational Suppressor 4E-BP1. Mitchell DC, Menon A, Garner AL. Cell Chem Biol. 2019 Jul 18;26(7):980-990.e8. doi: 10.1016/j.chembiol.2019.03.012. Epub 2019 May 2. PubMed |
| Genome-Wide CRISPR Screening Identifies the Tumor Suppressor Candidate OVCA2 As a Determinant of Tolerance to Acetaldehyde. Sobh A, Loguinov A, Stornetta A, Balbo S, Tagmount A, Zhang L, Vulpe CD. Toxicol Sci. 2019 May 1;169(1):235-245. doi: 10.1093/toxsci/kfz037. PubMed |
| BIRC5 is a target for molecular imaging and detection of human pancreatic cancer. Liu SH, Hong Y, Markowiak S, Sanchez R, Creeden J, Nemunaitis J, Kalinoski A, Willey J, Erhardt P, Lee J, van Dam M, Brunicardi FC. Cancer Lett. 2019 Aug 10;457:10-19. doi: 10.1016/j.canlet.2019.04.036. Epub 2019 May 3. PubMed |
| Inhibiting pathologically active ADAM10 rescues synaptic and cognitive decline in Huntington's disease. Vezzoli E, Caron I, Talpo F, Besusso D, Conforti P, Battaglia E, Sogne E, Falqui A, Petricca L, Verani M, Martufi P, Caricasole A, Bresciani A, Cecchetti O, Rivetti di Val Cervo P, Sancini G, Riess O, Nguyen H, Seipold L, Saftig P, Biella G, Cattaneo E, Zuccato C. J Clin Invest. 2019 May 6;130:2390-2403. doi: 10.1172/JCI120616. eCollection 2019 May 6. PubMed |
| Deficiency of stress-associated gene Nupr1 increases bone volume by attenuating differentiation of osteoclasts and enhancing differentiation of osteoblasts. Shiraki M, Xu X, Iovanna JL, Kukita T, Hirata H, Kamohara A, Kubota Y, Miyamoto H, Mawatari M, Kukita A. FASEB J. 2019 Aug;33(8):8836-8852. doi: 10.1096/fj.201802322RR. Epub 2019 May 8. PubMed |
| The ER Membrane Protein Complex Promotes Biogenesis of Dengue and Zika Virus Non-structural Multi-pass Transmembrane Proteins to Support Infection. Lin DL, Inoue T, Chen YJ, Chang A, Tsai B, Tai AW. Cell Rep. 2019 May 7;27(6):1666-1674.e4. doi: 10.1016/j.celrep.2019.04.051. PubMed |
| Effects of histone deacetylase inhibitor Scriptaid and parathyroid hormone on osteocyte functions and metabolism. Sun N, Uda Y, Azab E, Kochen A, Santos RNCE, Shi C, Kobayashi T, Wein MN, Divieti Pajevic P. J Biol Chem. 2019 Jun 21;294(25):9722-9733. doi: 10.1074/jbc.RA118.007312. Epub 2019 May 8. PubMed |
| HDAC1,2 Knock-Out and HDACi Induced Cell Apoptosis in Imatinib-Resistant K562 Cells. Chen SH, Chow JM, Hsieh YY, Lin CY, Hsu KW, Hsieh WS, Chi WM, Shabangu BM, Lee CH. Int J Mol Sci. 2019 May 8;20(9). pii: ijms20092271. doi: 10.3390/ijms20092271. PubMed |
| Sox17 is required for endothelial regeneration following inflammation-induced vascular injury. Liu M, Zhang L, Marsboom G, Jambusaria A, Xiong S, Toth PT, Benevolenskaya EV, Rehman J, Malik AB. Nat Commun. 2019 May 9;10(1):2126. doi: 10.1038/s41467-019-10134-y. PubMed |
| CCAAT/enhancer binding protein delta (C/EBPdelta) demonstrates a dichotomous role in tumour initiation and promotion of epithelial carcinoma. Sowamber R, Chehade R, Bitar M, Dodds LV, Milea A, Slomovitz B, Shaw PA, George SHL. EBioMedicine. 2019 Jun;44:261-274. doi: 10.1016/j.ebiom.2019.05.002. Epub 2019 May 9. PubMed |
| Identification of Cancer Drivers at CTCF Insulators in 1,962 Whole Genomes. Liu EM, Martinez-Fundichely A, Diaz BJ, Aronson B, Cuykendall T, MacKay M, Dhingra P, Wong EWP, Chi P, Apostolou E, Sanjana NE, Khurana E. Cell Syst. 2019 May 22;8(5):446-455.e8. doi: 10.1016/j.cels.2019.04.001. Epub 2019 May 8. PubMed |
| Targeted therapy based on p53 reactivation reduces both glioblastoma cell growth and resistance to temozolomide. Forte IM, Indovina P, Iannuzzi CA, Cirillo D, Di Marzo D, Barone D, Capone F, Pentimalli F, Giordano A. Int J Oncol. 2019 Jun;54(6):2189-2199. doi: 10.3892/ijo.2019.4788. Epub 2019 Apr 16. PubMed |
| The long noncoding RNA TP73-AS1 promotes tumorigenicity of medulloblastoma cells. Varon M, Levy T, Mazor G, Ben David H, Marciano R, Krelin Y, Prasad M, Elkabets M, Pauck D, Ahmadov U, Picard D, Qin N, Borkhardt A, Reifenberger G, Leprivier G, Remke M, Rotblat B. Int J Cancer. 2019 May 13. doi: 10.1002/ijc.32400. PubMed |
| A 3D culture model of innervated human skeletal muscle enables studies of the adult neuromuscular junction. Afshar Bakooshli M, Lippmann ES, Mulcahy B, Iyer N, Nguyen CT, Tung K, Stewart BA, van den Dorpel H, Fuehrmann T, Shoichet M, Bigot A, Pegoraro E, Ahn H, Ginsberg H, Zhen M, Ashton RS, Gilbert PM. Elife. 2019 May 14;8. pii: 44530. doi: 10.7554/eLife.44530. PubMed |
| A standard procedure for lentiviral-mediated labeling of murine mesenchymal stromal cells in vitro. Lupan AM, Preda MB, Burlacu A. Biotechnol Appl Biochem. 2019 May 14. doi: 10.1002/bab.1765. PubMed |
| MEIS1 knockdown may promote differentiation of esophageal squamous carcinoma cell line KYSE-30. Mahmoudian RA, Bahadori B, Rad A, Abbaszadegan MR, Forghanifard MM. Mol Genet Genomic Med. 2019 Jul;7(7):e00746. doi: 10.1002/mgg3.746. Epub 2019 May 14. PubMed |
| c-FLIP and CD95 signaling are essential for survival of renal cell carcinoma. Luebke T, Schwarz L, Beer YY, Schumann S, Misterek M, Sander FE, Plaza-Sirvent C, Schmitz I. Cell Death Dis. 2019 May 16;10(6):384. doi: 10.1038/s41419-019-1609-y. PubMed |
| MEK inhibitors activate Wnt signalling and induce stem cell plasticity in colorectal cancer. Zhan T, Ambrosi G, Wandmacher AM, Rauscher B, Betge J, Rindtorff N, Haussler RS, Hinsenkamp I, Bamberg L, Hessling B, Muller-Decker K, Erdmann G, Burgermeister E, Ebert MP, Boutros M. Nat Commun. 2019 May 16;10(1):2197. doi: 10.1038/s41467-019-09898-0. PubMed |
| Longitudinal Analysis of the Human B Cell Response to Ebola Virus Infection. Davis CW, Jackson KJL, McElroy AK, Halfmann P, Huang J, Chennareddy C, Piper AE, Leung Y, Albarino CG, Crozier I, Ellebedy AH, Sidney J, Sette A, Yu T, Nielsen SCA, Goff AJ, Spiropoulou CF, Saphire EO, Cavet G, Kawaoka Y, Mehta AK, Glass PJ, Boyd SD, Ahmed R. Cell. 2019 May 30;177(6):1566-1582.e17. doi: 10.1016/j.cell.2019.04.036. Epub 2019 May 16. PubMed |
| Human Neonatal Fc Receptor Is the Cellular Uncoating Receptor for Enterovirus B. Zhao X, Zhang G, Liu S, Chen X, Peng R, Dai L, Qu X, Li S, Song H, Gao Z, Yuan P, Liu Z, Li C, Shang Z, Li Y, Zhang M, Qi J, Wang H, Du N, Wu Y, Bi Y, Gao S, Shi Y, Yan J, Zhang Y, Xie Z, Wei W, Gao GF. Cell. 2019 May 30;177(6):1553-1565.e16. doi: 10.1016/j.cell.2019.04.035. Epub 2019 May 16. PubMed |
| TNF-alpha/IL-1beta-licensed mesenchymal stromal cells promote corneal allograft survival via myeloid cell-mediated induction of Foxp3(+) regulatory T cells in the lung. Murphy N, Treacy O, Lynch K, Morcos M, Lohan P, Howard L, Fahy G, Griffin MD, Ryan AE, Ritter T. FASEB J. 2019 Aug;33(8):9404-9421. doi: 10.1096/fj.201900047R. Epub 2019 May 20. PubMed |
| Aberrant methylation status of SPG20 promoter in hepatocellular carcinoma: A potential tumor metastasis biomarker. He L, Fan X, Li Y, Cui B, Shi Z, Zhou D, Lin H. Cancer Genet. 2019 Apr;233-234:48-55. doi: 10.1016/j.cancergen.2019.04.003. Epub 2019 Apr 12. PubMed |
| Parenchymal and stromal tissue regeneration of tooth organ by pivotal signals reinstated in decellularized matrix. He L, Zhou J, Chen M, Lin CS, Kim SG, Zhou Y, Xiang L, Xie M, Bai H, Yao H, Shi C, Coelho PG, Bromage TG, Hu B, Tovar N, Witek L, Wu J, Chen K, Gu W, Zheng J, Sheu TJ, Zhong J, Wen J, Niu Y, Cheng B, Gong Q, Owens DM, Stanislauskas M, Pei J, Chotkowski G, Wang S, Yang G, Zegarelli DJ, Shi X, Finkel M, Zhang W, Li J, Cheng J, Tarnow DP, Zhou X, Wang Z, Jiang X, Romanov A, Rowe DW, Wang S, Ye L, Ling J, Mao J. Nat Mater. 2019 Jun;18(6):627-637. doi: 10.1038/s41563-019-0368-6. Epub 2019 May 21. PubMed |
| Mitohormesis Primes Tumor Invasion and Metastasis. Kenny TC, Craig AJ, Villanueva A, Germain D. Cell Rep. 2019 May 21;27(8):2292-2303.e6. doi: 10.1016/j.celrep.2019.04.095. PubMed |
| Detection and Quantification of Label-Free Infectious Adenovirus Using a Switch-On Cell-Based Fluorescent Biosensor. Guerreiro MR, Freitas DF, Alves PM, Coroadinha AS. ACS Sens. 2019 Jun 28;4(6):1654-1661. doi: 10.1021/acssensors.9b00489. Epub 2019 Jun 5. PubMed |
| A conserved PLPLRT/SD motif of STING mediates the recruitment and activation of TBK1. Zhao B, Du F, Xu P, Shu C, Sankaran B, Bell SL, Liu M, Lei Y, Gao X, Fu X, Zhu F, Liu Y, Laganowsky A, Zheng X, Ji JY, West AP, Watson RO, Li P. Nature. 2019 May;569(7758):718-722. doi: 10.1038/s41586-019-1228-x. Epub 2019 May 22. PubMed |
| Assessment of PARP4 as a candidate breast cancer susceptibility gene. Prawira A, Munusamy P, Yuan J, Chan CHT, Koh GL, Shuen TWH, Hu J, Yap YS, Tan MH, Ang P, Lee ASG. Breast Cancer Res Treat. 2019 Aug;177(1):145-153. doi: 10.1007/s10549-019-05286-w. Epub 2019 May 22. PubMed |
| Deciphering host lysosome-mediated elimination of Plasmodium berghei liver stage parasites. Niklaus L, Agop-Nersesian C, Schmuckli-Maurer J, Wacker R, Grunig V, Heussler VT. Sci Rep. 2019 May 28;9(1):7967. doi: 10.1038/s41598-019-44449-z. PubMed |
| Lentiviral CRISPR Epigenome Editing of Inflammatory Receptors as a Gene Therapy Strategy for Disc Degeneration. Farhang N, Ginley-Hidinger M, Berrett KC, Gertz J, Lawrence B, Bowles RD. Hum Gene Ther. 2019 Jul 17. doi: 10.1089/hum.2019.005. PubMed |
| A Yeast Suppressor Screen Used To Identify Mammalian SIRT1 as a Proviral Factor for Middle East Respiratory Syndrome Coronavirus Replication. Weston S, Matthews KL, Lent R, Vlk A, Haupt R, Kingsbury T, Frieman MB. J Virol. 2019 Jul 30;93(16). pii: JVI.00197-19. doi: 10.1128/JVI.00197-19. Print 2019 Aug 15. PubMed |
| Allele-specific silencing as treatment for gene duplication disorders: proof-of-principle in autosomal dominant leukodystrophy. Giorgio E, Lorenzati M, Rivetti di Val Cervo P, Brussino A, Cernigoj M, Della Sala E, Bartoletti Stella A, Ferrero M, Caiazzo M, Capellari S, Cortelli P, Conti L, Cattaneo E, Buffo A, Brusco A. Brain. 2019 May 29. pii: 5506062. doi: 10.1093/brain/awz139. PubMed |
| Two human patient mitochondrial pyruvate carrier mutations reveal distinct molecular mechanisms of dysfunction. Oonthonpan L, Rauckhorst AJ, Gray LR, Boutron AC, Taylor EB. JCI Insight. 2019 May 30;5. pii: 126132. doi: 10.1172/jci.insight.126132. PubMed |
| LIM and SH3 protein 1 induces glioma growth and invasion through PI3K/AKT signaling and epithelial-mesenchymal transition. Zhong C, Li X, Tao B, Peng L, Peng T, Yang X, Xia X, Chen L. Biomed Pharmacother. 2019 Aug;116:109013. doi: 10.1016/j.biopha.2019.109013. Epub 2019 May 27. PubMed |
| Generation of an immortalized erythroid progenitor cell line from peripheral blood: A model system for the functional analysis of Plasmodium spp. invasion. Scully EJ, Shabani E, Rangel GW, Gruring C, Kanjee U, Clark MA, Chaand M, Kurita R, Nakamura Y, Ferreira MU, Duraisingh MT. Am J Hematol. 2019 May 31. doi: 10.1002/ajh.25543. PubMed |
| Thermoregulation via Temperature-Dependent PGD2 Production in Mouse Preoptic Area. Wang TA, Teo CF, Akerblom M, Chen C, Tynan-La Fontaine M, Greiner VJ, Diaz A, McManus MT, Jan YN, Jan LY. Neuron. 2019 Jul 17;103(2):309-322.e7. doi: 10.1016/j.neuron.2019.04.035. Epub 2019 May 28. PubMed |
| A PRDM16-Driven Metabolic Signal from Adipocytes Regulates Precursor Cell Fate. Wang W, Ishibashi J, Trefely S, Shao M, Cowan AJ, Sakers A, Lim HW, O'Connor S, Doan MT, Cohen P, Baur JA, King MT, Veech RL, Won KJ, Rabinowitz JD, Snyder NW, Gupta RK, Seale P. Cell Metab. 2019 Jul 2;30(1):174-189.e5. doi: 10.1016/j.cmet.2019.05.005. Epub 2019 May 30. PubMed |
| Development of an improved lentiviral based vector system for the stable expression of monoclonal antibody in CHO cells. Mohammadian O, Rajabibazl M, Pourmaleki E, Bayat H, Ahani R, Rahimpour A. Prep Biochem Biotechnol. 2019;49(8):822-829. doi: 10.1080/10826068.2019.1621893. Epub 2019 Jun 1. PubMed |
| EMSY expression affects multiple components of the skin barrier with relevance to atopic dermatitis. Elias MS, Wright SC, Remenyi J, Abbott JC, Bray SE, Cole C, Edwards S, Gierlinski M, Glok M, McGrath JA, Nicholson WV, Paternoster L, Prescott AR, Have ST, Whitfield PD, Lamond AI, Brown SJ. J Allergy Clin Immunol. 2019 May 31. pii: S0091-6749(19)30741-9. doi: 10.1016/j.jaci.2019.05.024. PubMed |
| Discovery of a Pathogenic Variant rs139379666 (p. P2974L) in ATM for Breast Cancer Risk in Chinese Populations. Guo X, Lin W, Bai M, Li H, Wen W, Zeng C, Chen Z, He J, Chen J, Cai Q, Long J, Jia WH, Shu XO, Zheng W. Cancer Epidemiol Biomarkers Prev. 2019 Aug;28(8):1308-1315. doi: 10.1158/1055-9965.EPI-18-1294. Epub 2019 Jun 3. PubMed |
| Opposing effects of acute versus chronic inhibition of p53 on decitabine's efficacy in myeloid neoplasms. Tamura M, Yonezawa T, Liu X, Asada S, Hayashi Y, Fukuyama T, Tanaka Y, Kitamura T, Goyama S. Sci Rep. 2019 Jun 3;9(1):8171. doi: 10.1038/s41598-019-44496-6. PubMed |
| The length of guide RNA and target DNA heteroduplex effects on CRISPR/Cas9 mediated genome editing efficiency in porcine cells. Lv J, Wu S, Wei R, Li Y, Jin J, Mu Y, Zhang Y, Kong Q, Weng X, Liu Z. J Vet Sci. 2019 May;20(3):e23. doi: 10.4142/jvs.2019.20.e23. PubMed |
| The Effect of FERMT1 Regulated by miR-24 on the Growth and Radiation Resistance of Esophageal Cancer. Yan Q, Chen T, Yang H, Yu H, Zheng Y, He T, Wang J. J Biomed Nanotechnol. 2019 Mar 1;15(3):621-631. doi: 10.1166/jbn.2019.2711. PubMed |
| Overexpression of zinc finger protein 384 (ZNF 384), a poor prognostic predictor, promotes cell growth by upregulating the expression of Cyclin D1 in Hepatocellular carcinoma. He L, Fan X, Li Y, Chen M, Cui B, Chen G, Dai Y, Zhou D, Hu X, Lin H. Cell Death Dis. 2019 Jun 5;10(6):444. doi: 10.1038/s41419-019-1681-3. PubMed |
| An NLRP3 inflammasome-triggered cytokine storm contributes to Streptococcal toxic shock-like syndrome (STSLS). Lin L, Xu L, Lv W, Han L, Xiang Y, Fu L, Jin M, Zhou R, Chen H, Zhang A. PLoS Pathog. 2019 Jun 6;15(6):e1007795. doi: 10.1371/journal.ppat.1007795. eCollection 2019 Jun. PubMed |
| Chemical screen for epigenetic barriers to single allele activation of Oct4. Headley KM, Kedziora KM, Alejo A, Lai EZ, Purvis JE, Hathaway NA. Stem Cell Res. 2019 Jul;38:101470. doi: 10.1016/j.scr.2019.101470. Epub 2019 May 24. PubMed |
| Clustered telomeres in phase-separated nuclear condensates engage mitotic DNA synthesis through BLM and RAD52. Min J, Wright WE, Shay JW. Genes Dev. 2019 Jul 1;33(13-14):814-827. doi: 10.1101/gad.324905.119. Epub 2019 Jun 6. PubMed |
| A novel YAP1/SLC35B4 regulatory axis contributes to proliferation and progression of gastric carcinoma. Liu J, Zhao X, Wang K, Zhang X, Yu Y, Lv Y, Zhang S, Zhang L, Guo Y, Li Y, Yang A, Zhang R, Li J. Cell Death Dis. 2019 Jun 7;10(6):452. doi: 10.1038/s41419-019-1674-2. PubMed |
| Embryonic Chimeras with Human Pluripotent Stem Cells. De Los Angeles A, Sakurai M, Wu J. Methods Mol Biol. 2019;2005:125-151. doi: 10.1007/978-1-4939-9524-0_9. PubMed |
| Metabolic stress activates an ERK/hnRNPK/DDX3X pathway in pancreatic beta cells. Good AL, Haemmerle MW, Oguh AU, Doliba NM, Stoffers DA. Mol Metab. 2019 Aug;26:45-56. doi: 10.1016/j.molmet.2019.05.009. Epub 2019 May 24. PubMed |
| Symbiotic Macrophage-Glioma Cell Interactions Reveal Synthetic Lethality in PTEN-Null Glioma. Chen P, Zhao D, Li J, Liang X, Li J, Chang A, Henry VK, Lan Z, Spring DJ, Rao G, Wang YA, DePinho RA. Cancer Cell. 2019 Jun 10;35(6):868-884.e6. doi: 10.1016/j.ccell.2019.05.003. PubMed |
| Extensive Epitranscriptomic Methylation of A and C Residues on Murine Leukemia Virus Transcripts Enhances Viral Gene Expression. Courtney DG, Chalem A, Bogerd HP, Law BA, Kennedy EM, Holley CL, Cullen BR. MBio. 2019 Jun 11;10(3). pii: mBio.01209-19. doi: 10.1128/mBio.01209-19. PubMed |
| KMT5A promotes metastasis of clear cell renal cell carcinoma through reducing cadherin-1 expression. Lin ZZ, Ming DS, Chen YB, Zhang JM, Chen HH, Jiang JJ, Zhang ZS. Oncol Lett. 2019 Jun;17(6):4907-4913. doi: 10.3892/ol.2019.10163. Epub 2019 Mar 19. PubMed |
| Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome. Sharif H, Wang L, Wang WL, Magupalli VG, Andreeva L, Qiao Q, Hauenstein AV, Wu Z, Nunez G, Mao Y, Wu H. Nature. 2019 Jun;570(7761):338-343. doi: 10.1038/s41586-019-1295-z. Epub 2019 Jun 12. PubMed |
| Self-assembled nanofibrils from RGD-functionalized cellulose nanocrystals to improve the performance of PEI/DNA polyplexes. Hujaya SD, Manninen A, Kling K, Wagner JB, Vainio SJ, Liimatainen H. J Colloid Interface Sci. 2019 Jun 3;553:71-82. doi: 10.1016/j.jcis.2019.06.001. PubMed |
| MHC-I peptide binding activity assessed by exchange after cleavage of peptide covalently linked to beta2-microglobulin. Jurewicz MM, Willis RA, Altman JD, Stern LJ. Anal Biochem. 2019 Jun 12. pii: S0003-2697(19)30180-0. doi: 10.1016/j.ab.2019.05.017. PubMed |
| Abundance of d-2-hydroxyglutarate in G2/M is determined by FOXM1 in mutant IDH1-expressing cells. Bala Bhaskara Rao K, Katragunta K, Sarma UM, Jain N. FEBS Lett. 2019 Jun 18. doi: 10.1002/1873-3468.13500. PubMed |
| p73 regulates epidermal wound healing and induced keratinocyte programming. Beeler JS, Marshall CB, Gonzalez-Ericsson PI, Shaver TM, Santos Guasch GL, Lea ST, Johnson KN, Jin H, Venters BJ, Sanders ME, Pietenpol JA. PLoS One. 2019 Jun 19;14(6):e0218458. doi: 10.1371/journal.pone.0218458. eCollection 2019. PubMed |
| Enhancement of LIN28B-induced hematopoietic reprogramming by IGF2BP3. Wang S, Chim B, Su Y, Khil P, Wong M, Wang X, Foroushani A, Smith PT, Liu X, Li R, Ganesan S, Kanellopoulou C, Hafner M, Muljo SA. Genes Dev. 2019 Aug 1;33(15-16):1048-1068. doi: 10.1101/gad.325100.119. Epub 2019 Jun 20. PubMed |
| DEPTOR induces a partial epithelial-to-mesenchymal transition and metastasis via autocrine TGFbeta1 signaling and is associated with poor prognosis in hepatocellular carcinoma. Chen J, Zhu H, Liu Q, Ning D, Zhang Z, Zhang L, Mo J, Du P, Liu X, Song S, Fan Y, Liang H, Liu J, Zhang B, Chen X. J Exp Clin Cancer Res. 2019 Jun 22;38(1):273. doi: 10.1186/s13046-019-1220-1. PubMed |
| An Oxygen-Dependent Interaction between FBXL5 and the CIA-Targeting Complex Regulates Iron Homeostasis. Mayank AK, Pandey V, Vashisht AA, Barshop WD, Rayatpisheh S, Sharma T, Haque T, Powers DN, Wohlschlegel JA. Mol Cell. 2019 Jul 25;75(2):382-393.e5. doi: 10.1016/j.molcel.2019.05.020. Epub 2019 Jun 19. PubMed |
| Zika virus NS5 protein inhibits cell growth and invasion of glioma. Li H, Hu Y, Huang J, Feng Y, Zhang Z, Zhong K, Chen Y, Wang Z, Huang C, Yang H, Tong A. Biochem Biophys Res Commun. 2019 Aug 20;516(2):515-520. doi: 10.1016/j.bbrc.2019.06.064. Epub 2019 Jun 20. PubMed |
Single-Cell Transcriptomic Analyses of Cell Fate Transitions during Human Cardiac Reprogramming.
Zhou Y, Liu Z, Welch JD, Gao X, Wang L, Garbutt T, Keepers B, Ma H, Prins JF, Shen W, Liu J, Qian L.
Cell Stem Cell. 2019 Jul 3;25(1):149-164.e9. doi: 10.1016/j.stem.2019.05.020. Epub 2019 Jun 20.
PubMed
Associated Plasmids |
| High-throughput multicolor optogenetics in microwell plates. Bugaj LJ, Lim WA. Nat Protoc. 2019 Jul;14(7):2205-2228. doi: 10.1038/s41596-019-0178-y. Epub 2019 Jun 24. PubMed |
| Pancreatic Ductal Organoids React Kras Dependent to the Removal of Tumor Suppressive Roadblocks. Perkhofer L, Engler M, Gout J, Arnold F, Morawe M, Breunig M, Seufferlein T, Kleger A, Frappart PO. Stem Cells Int. 2019 May 19;2019:2079742. doi: 10.1155/2019/2079742. eCollection 2019. PubMed |
| Alcohol Effects on Colon Epithelium are Time-Dependent. Bishehsari F, Zhang L, Voigt RM, Maltby N, Semsarieh B, Zorub E, Shaikh M, Wilber S, Armstrong AR, Mirbagheri SS, Preite NZ, Song P, Stornetta A, Balbo S, Forsyth CB, Keshavarzian A. Alcohol Clin Exp Res. 2019 Jun 25. doi: 10.1111/acer.14141. PubMed |
| CELF2 suppresses non-small cell lung carcinoma growth by inhibiting the PREX2-PTEN interaction. Yeung YT, Fan S, Lu B, Yin S, Yang S, Nie W, Wang M, Zhou L, Li T, Li X, Bode AM, Dong Z. Carcinogenesis. 2019 Jun 25. pii: 5523300. doi: 10.1093/carcin/bgz113. PubMed |
| Loss of the transcription factor RBPJ induces disease-promoting properties in brain pericytes. Dieguez-Hurtado R, Kato K, Giaimo BD, Nieminen-Kelha M, Arf H, Ferrante F, Bartkuhn M, Zimmermann T, Bixel MG, Eilken HM, Adams S, Borggrefe T, Vajkoczy P, Adams RH. Nat Commun. 2019 Jun 27;10(1):2817. doi: 10.1038/s41467-019-10643-w. PubMed |
| Nutrient availability shapes methionine metabolism in p16/MTAP-deleted cells. Sanderson SM, Mikhael PG, Ramesh V, Dai Z, Locasale JW. Sci Adv. 2019 Jun 26;5(6):eaav7769. doi: 10.1126/sciadv.aav7769. eCollection 2019 Jun. PubMed |
| Establishment of a system for screening autophagic flux regulators using a modified fluorescent reporter and CRISPR/Cas9. Yazawa R, Nishida Y, Aoyama S, Tanida I, Miyatsuka T, Suzuki L, Himuro M, Haruna H, Takubo N, Shimizu T, Watada H. Biochem Biophys Res Commun. 2019 Aug 27;516(3):686-692. doi: 10.1016/j.bbrc.2019.06.129. Epub 2019 Jun 26. PubMed |
WDFY2 restrains matrix metalloproteinase secretion and cell invasion by controlling VAMP3-dependent recycling.
Sneeggen M, Pedersen NM, Campsteijn C, Haugsten EM, Stenmark H, Schink KO.
Nat Commun. 2019 Jun 28;10(1):2850. doi: 10.1038/s41467-019-10794-w.
PubMed
Associated Plasmids |
| Mitophagy Failure in APP and Tau Overexpression Model of Alzheimer's Disease. Martin-Maestro P, Gargini R, Garcia E, Simon D, Avila J, Garcia-Escudero V. J Alzheimers Dis. 2019;70(2):525-540. doi: 10.3233/JAD-190086. PubMed |
| BACH1 Stabilization by Antioxidants Stimulates Lung Cancer Metastasis. Wiel C, Le Gal K, Ibrahim MX, Jahangir CA, Kashif M, Yao H, Ziegler DV, Xu X, Ghosh T, Mondal T, Kanduri C, Lindahl P, Sayin VI, Bergo MO. Cell. 2019 Jul 11;178(2):330-345.e22. doi: 10.1016/j.cell.2019.06.005. Epub 2019 Jun 27. PubMed |
| Functional Relevance of Interleukin-1 Receptor Inter-domain Flexibility for Cytokine Binding and Signaling. Ge J, Remesh SG, Hammel M, Pan S, Mahan AD, Wang S, Wang X. Structure. 2019 Aug 6;27(8):1296-1307.e5. doi: 10.1016/j.str.2019.05.011. Epub 2019 Jun 27. PubMed |
| Bmi1 Suppresses Adipogenesis in the Hematopoietic Stem Cell Niche. Hu T, Kitano A, Luu V, Dawson B, Hoegenauer KA, Lee BH, Nakada D. Stem Cell Reports. 2019 Sep 10;13(3):545-558. doi: 10.1016/j.stemcr.2019.05.027. Epub 2019 Jun 27. PubMed |
| SNAI2 3'untranslated region promotes the invasion of ovarian cancer cells by inducing MARCKS expression. Li J, Wang J, Yue H, Lu X. J Cancer. 2019 Jun 2;10(11):2480-2487. doi: 10.7150/jca.29489. eCollection 2019. PubMed |
| An ErbB2/c-Src axis links bioenergetics with PRC2 translation to drive epigenetic reprogramming and mammary tumorigenesis. Smith HW, Hirukawa A, Sanguin-Gendreau V, Nandi I, Dufour CR, Zuo D, Tandoc K, Leibovitch M, Singh S, Rennhack JP, Swiatnicki M, Lavoie C, Papavasiliou V, Temps C, Carragher NO, Unciti-Broceta A, Savage P, Basik M, van Hoef V, Larsson O, Cooper CL, Vargas Calderon AC, Beith J, Millar E, Selinger C, Giguere V, Park M, Harris LN, Varadan V, Andrechek ER, O'Toole SA, Topisirovic I, Muller WJ. Nat Commun. 2019 Jul 1;10(1):2901. doi: 10.1038/s41467-019-10681-4. PubMed |
Human GBP1 is a microbe-specific gatekeeper of macrophage apoptosis and pyroptosis.
Fisch D, Bando H, Clough B, Hornung V, Yamamoto M, Shenoy AR, Frickel EM.
EMBO J. 2019 Jul 1;38(13):e100926. doi: 10.15252/embj.2018100926. Epub 2019 Jun 3.
PubMed
Associated Plasmids |
| Neuronal Soma-Derived Degradative Lysosomes Are Continuously Delivered to Distal Axons to Maintain Local Degradation Capacity. Farfel-Becker T, Roney JC, Cheng XT, Li S, Cuddy SR, Sheng ZH. Cell Rep. 2019 Jul 2;28(1):51-64.e4. doi: 10.1016/j.celrep.2019.06.013. PubMed |
| The metalloproteinase ADAM15 is upregulated by shear stress and promotes survival of endothelial cells. Babendreyer A, Molls L, Simons IM, Dreymueller D, Biller K, Jahr H, Denecke B, Boon RA, Bette S, Schnakenberg U, Ludwig A. J Mol Cell Cardiol. 2019 Jul 1;134:51-61. doi: 10.1016/j.yjmcc.2019.06.017. PubMed |
| Targeting hypoxia downstream signaling protein, CAIX, for CAR T-cell therapy against glioblastoma. Cui J, Zhang Q, Song Q, Wang H, Dmitriev P, Sun MY, Cao X, Wang Y, Guo L, Indig IH, Rosenblum JS, Ji C, Cao D, Yang K, Gilbert MR, Yao Y, Zhuang Z. Neuro Oncol. 2019 Nov 4;21(11):1436-1446. doi: 10.1093/neuonc/noz117. PubMed |
| Identification of the m(6)Am Methyltransferase PCIF1 Reveals the Location and Functions of m(6)Am in the Transcriptome. Boulias K, Toczydlowska-Socha D, Hawley BR, Liberman N, Takashima K, Zaccara S, Guez T, Vasseur JJ, Debart F, Aravind L, Jaffrey SR, Greer EL. Mol Cell. 2019 Jun 20. pii: S1097-2765(19)30439-3. doi: 10.1016/j.molcel.2019.06.006. PubMed |
| PCIF1 Catalyzes m6Am mRNA Methylation to Regulate Gene Expression. Sendinc E, Valle-Garcia D, Dhall A, Chen H, Henriques T, Navarrete-Perea J, Sheng W, Gygi SP, Adelman K, Shi Y. Mol Cell. 2019 Jun 18. pii: S1097-2765(19)30402-2. doi: 10.1016/j.molcel.2019.05.030. PubMed |
| Forkhead box K2 promotes human colorectal cancer metastasis by upregulating ZEB1 and EGFR. Du F, Qiao C, Li X, Chen Z, Liu H, Wu S, Hu S, Qiu Z, Qian M, Tian D, Wu K, Fan D, Nie Y, Xia L. Theranostics. 2019 May 31;9(13):3879-3902. doi: 10.7150/thno.31716. eCollection 2019. PubMed |
| Covalent targeting of the vacuolar H(+)-ATPase activates autophagy via mTORC1 inhibition. Chung CY, Shin HR, Berdan CA, Ford B, Ward CC, Olzmann JA, Zoncu R, Nomura DK. Nat Chem Biol. 2019 Aug;15(8):776-785. doi: 10.1038/s41589-019-0308-4. Epub 2019 Jul 8. PubMed |
| Genomic and Transcriptomic Determinants of Therapy Resistance and Immune Landscape Evolution during Anti-EGFR Treatment in Colorectal Cancer. Woolston A, Khan K, Spain G, Barber LJ, Griffiths B, Gonzalez-Exposito R, Hornsteiner L, Punta M, Patil Y, Newey A, Mansukhani S, Davies MN, Furness A, Sclafani F, Peckitt C, Jimenez M, Kouvelakis K, Ranftl R, Begum R, Rana I, Thomas J, Bryant A, Quezada S, Wotherspoon A, Khan N, Fotiadis N, Marafioti T, Powles T, Lise S, Calvo F, Guettler S, von Loga K, Rao S, Watkins D, Starling N, Chau I, Sadanandam A, Cunningham D, Gerlinger M. Cancer Cell. 2019 Jul 8;36(1):35-50.e9. doi: 10.1016/j.ccell.2019.05.013. PubMed |
| Conserved Herpesvirus Protein Kinases Target SAMHD1 to Facilitate Virus Replication. Zhang K, Lv DW, Li R. Cell Rep. 2019 Jul 9;28(2):449-459.e5. doi: 10.1016/j.celrep.2019.04.020. PubMed |
| Quantitative characterization of 3D bioprinted structural elements under cell generated forces. Morley CD, Ellison ST, Bhattacharjee T, O'Bryan CS, Zhang Y, Smith KF, Kabb CP, Sebastian M, Moore GL, Schulze KD, Niemi S, Sawyer WG, Tran DD, Mitchell DA, Sumerlin BS, Flores CT, Angelini TE. Nat Commun. 2019 Jul 10;10(1):3029. doi: 10.1038/s41467-019-10919-1. PubMed |
| Acetylation of BMAL1 by TIP60 controls BRD4-P-TEFb recruitment to circadian promoters. Petkau N, Budak H, Zhou X, Oster H, Eichele G. Elife. 2019 Jul 11;8. pii: 43235. doi: 10.7554/eLife.43235. PubMed |
| The orphan nuclear receptor SHP regulates ER stress response by inhibiting XBP1s degradation. Sun S, Kelekar S, Kliewer SA, Mangelsdorf DJ. Genes Dev. 2019 Aug 1;33(15-16):1083-1094. doi: 10.1101/gad.326868.119. Epub 2019 Jul 11. PubMed |
Delivering Cas9/sgRNA ribonucleoprotein (RNP) by lentiviral capsid-based bionanoparticles for efficient 'hit-and-run' genome editing.
Lyu P, Javidi-Parsijani P, Atala A, Lu B.
Nucleic Acids Res. 2019 Jul 12. pii: 5531787. doi: 10.1093/nar/gkz605.
PubMed
Associated Plasmids |
| IKKalpha Kinase Regulates the DNA Damage Response and Drives Chemo-resistance in Cancer. Colomer C, Margalef P, Villanueva A, Vert A, Pecharroman I, Sole L, Gonzalez-Farre M, Alonso J, Montagut C, Martinez-Iniesta M, Bertran J, Borras E, Iglesias M, Sabido E, Bigas A, Boulton SJ, Espinosa L. Mol Cell. 2019 Aug 22;75(4):669-682.e5. doi: 10.1016/j.molcel.2019.05.036. Epub 2019 Jul 10. PubMed |
| Augmenting Immunotherapy Impact by Lowering Tumor TNF Cytotoxicity Threshold. Vredevoogd DW, Kuilman T, Ligtenberg MA, Boshuizen J, Stecker KE, de Bruijn B, Krijgsman O, Huang X, Kenski JCN, Lacroix R, Mezzadra R, Gomez-Eerland R, Yildiz M, Dagidir I, Apriamashvili G, Zandhuis N, van der Noort V, Visser NL, Blank CU, Altelaar M, Schumacher TN, Peeper DS. Cell. 2019 Jul 25;178(3):585-599.e15. doi: 10.1016/j.cell.2019.06.014. Epub 2019 Jul 11. PubMed |
Mechanisms of Progression of Myeloid Preleukemia to Transformed Myeloid Leukemia in Children with Down Syndrome.
Labuhn M, Perkins K, Matzk S, Varghese L, Garnett C, Papaemmanuil E, Metzner M, Kennedy A, Amstislavskiy V, Risch T, Bhayadia R, Samulowski D, Hernandez DC, Stoilova B, Iotchkova V, Oppermann U, Scheer C, Yoshida K, Schwarzer A, Taub JW, Crispino JD, Weiss MJ, Hayashi Y, Taga T, Ito E, Ogawa S, Reinhardt D, Yaspo ML, Campbell PJ, Roberts I, Constantinescu SN, Vyas P, Heckl D, Klusmann JH.
Cancer Cell. 2019 Aug 12;36(2):123-138.e10. doi: 10.1016/j.ccell.2019.06.007. Epub 2019 Jul 11.
PubMed
Associated Plasmids |
Engineering Forward Genetics into Cultured Cancer Cells for Chemical Target Identification.
Povedano JM, Liou J, Wei D, Srivatsav A, Kim J, Xie Y, Nijhawan D, McFadden DG.
Cell Chem Biol. 2019 Sep 19;26(9):1315-1321.e3. doi: 10.1016/j.chembiol.2019.06.006. Epub 2019 Jul 11.
PubMed
Associated Plasmids |
| Activation of the autophagy pathway by Torovirus infection is irrelevant for virus replication. Avila-Perez G, Diaz-Beneitez E, Cubas-Gaona LL, Nieves-Molina G, Rodriguez JR, Rodriguez JF, Rodriguez D. PLoS One. 2019 Jul 15;14(7):e0219428. doi: 10.1371/journal.pone.0219428. eCollection 2019. PubMed |
| SET Domain-Containing Protein 4 Epigenetically Controls Breast Cancer Stem Cell Quiescence. Ye S, Ding YF, Jia WH, Liu XL, Feng JY, Zhu Q, Cai SL, Yang YS, Lu QY, Huang XT, Yang JS, Jia SN, Ding GP, Wang YH, Zhou JJ, Chen YD, Yang WJ. Cancer Res. 2019 Sep 15;79(18):4729-4743. doi: 10.1158/0008-5472.CAN-19-1084. Epub 2019 Jul 15. PubMed |
| Membrane protein-regulated networks across human cancers. Lin CY, Lee CH, Chuang YH, Lee JY, Chiu YY, Wu Lee YH, Jong YJ, Hwang JK, Huang SH, Chen LC, Wu CH, Tu SH, Ho YS, Yang JM. Nat Commun. 2019 Jul 16;10(1):3131. doi: 10.1038/s41467-019-10920-8. PubMed |
Pooled library screening with multiplexed Cpf1 library.
Liu J, Srinivasan S, Li CY, Ho IL, Rose J, Shaheen M, Wang G, Yao W, Deem A, Bristow C, Hart T, Draetta G.
Nat Commun. 2019 Jul 17;10(1):3144. doi: 10.1038/s41467-019-10963-x.
PubMed
Associated Plasmids |
| Dynamic change of electrostatic field in TMEM16F permeation pathway shifts its ion selectivity. Ye W, Han TW, He M, Jan YN, Jan LY. Elife. 2019 Jul 18;8. pii: 45187. doi: 10.7554/eLife.45187. PubMed |
| The transporters SLC35A1 and SLC30A1 play opposite roles in cell survival upon VSV virus infection. Moskovskich A, Goldmann U, Kartnig F, Lindinger S, Konecka J, Fiume G, Girardi E, Superti-Furga G. Sci Rep. 2019 Jul 18;9(1):10471. doi: 10.1038/s41598-019-46952-9. PubMed |
| Loss of FGL1 induces epithelialmesenchymal transition and angiogenesis in LKB1 mutant lung adenocarcinoma. Bie F, Wang G, Qu X, Wang Y, Huang C, Wang Y, Du J. Int J Oncol. 2019 Sep;55(3):697-707. doi: 10.3892/ijo.2019.4838. Epub 2019 Jul 15. PubMed |
| CRISPR-Cas9 Mediated TSPO Gene Knockout alters Respiration and Cellular Metabolism in Human Primary Microglia Cells. Milenkovic VM, Slim D, Bader S, Koch V, Heinl ES, Alvarez-Carbonell D, Nothdurfter C, Rupprecht R, Wetzel CH. Int J Mol Sci. 2019 Jul 9;20(13). pii: ijms20133359. doi: 10.3390/ijms20133359. PubMed |
| A kinome-wide shRNA screen uncovers vaccinia-related kinase 3 (VRK3) as an essential gene for diffuse intrinsic pontine glioma survival. Silva-Evangelista C, Barret E, Menez V, Merlevede J, Kergrohen T, Saccasyn A, Oberlin E, Puget S, Beccaria K, Grill J, Castel D, Debily MA. Oncogene. 2019 Sep;38(38):6479-6490. doi: 10.1038/s41388-019-0884-5. Epub 2019 Jul 19. PubMed |
| PI31 Is an Adaptor Protein for Proteasome Transport in Axons and Required for Synaptic Development. Liu K, Jones S, Minis A, Rodriguez J, Molina H, Steller H. Dev Cell. 2019 Aug 19;50(4):509-524.e10. doi: 10.1016/j.devcel.2019.06.009. Epub 2019 Jul 18. PubMed |
| P11 Loss-of-Function is Associated with Decreased Cell Proliferation and Neurobehavioral Disorders in Mice. Liu G, Wang Y, Zheng W, Cheng H, Zhou R. Int J Biol Sci. 2019 May 20;15(7):1383-1395. doi: 10.7150/ijbs.33773. eCollection 2019. PubMed |
| Interferon-Inducible MicroRNA miR-128 Modulates HIV-1 Replication by Targeting TNPO3 mRNA. Bochnakian A, Zhen A, Zisoulis DG, Idica A, KewalRamani VN, Neel N, Daugaard I, Hamdorf M, Kitchen S, Lee K, Pedersen IM. J Virol. 2019 Sep 30;93(20). pii: JVI.00364-19. doi: 10.1128/JVI.00364-19. Print 2019 Oct 15. PubMed |
| Essential genes shape cancer genomes through linear limitation of homozygous deletions. Pertesi M, Ekdahl L, Palm A, Johnsson E, Jarvstrat L, Wihlborg AK, Nilsson B. Commun Biol. 2019 Jul 19;2:262. doi: 10.1038/s42003-019-0517-0. eCollection 2019. PubMed |
| PUMILIO, but not RBMX, binding is required for regulation of genomic stability by noncoding RNA NORAD. Elguindy MM, Kopp F, Goodarzi M, Rehfeld F, Thomas A, Chang TC, Mendell JT. Elife. 2019 Jul 25;8. pii: 48625. doi: 10.7554/eLife.48625. PubMed |
Towards a surrogate system to express human lipid binding TCRs.
Wang R, Pscheid R, Ghumra A, Kan LYL, Cochrane S, Fairclough L, Alcocer MJC.
Biotechnol Lett. 2019 Oct;41(10):1095-1104. doi: 10.1007/s10529-019-02713-2. Epub 2019 Jul 26.
PubMed
Associated Plasmids |
| Human Artificial Chromosomes that Bypass Centromeric DNA. Logsdon GA, Gambogi CW, Liskovykh MA, Barrey EJ, Larionov V, Miga KH, Heun P, Black BE. Cell. 2019 Jul 25;178(3):624-639.e19. doi: 10.1016/j.cell.2019.06.006. PubMed |
The AMPK-Related Kinases SIK1 and SIK3 Mediate Key Tumor-Suppressive Effects of LKB1 in NSCLC.
Hollstein PE, Eichner LJ, Brun SN, Kamireddy A, Svensson RU, Vera LI, Ross DS, Rymoff TJ, Hutchins A, Galvez HM, Williams AE, Shokhirev MN, Screaton RA, Berdeaux R, Shaw RJ.
Cancer Discov. 2019 Nov;9(11):1606-1627. doi: 10.1158/2159-8290.CD-18-1261. Epub 2019 Jul 26.
PubMed
Associated Plasmids |
| Stabilizing heterochromatin by DGCR8 alleviates senescence and osteoarthritis. Deng L, Ren R, Liu Z, Song M, Li J, Wu Z, Ren X, Fu L, Li W, Zhang W, Guillen P, Izpisua Belmonte JC, Chan P, Qu J, Liu GH. Nat Commun. 2019 Jul 26;10(1):3329. doi: 10.1038/s41467-019-10831-8. PubMed |
| Activation of PARP-1 by snoRNAs Controls Ribosome Biogenesis and Cell Growth via the RNA Helicase DDX21. Kim DS, Camacho CV, Nagari A, Malladi VS, Challa S, Kraus WL. Mol Cell. 2019 Sep 19;75(6):1270-1285.e14. doi: 10.1016/j.molcel.2019.06.020. Epub 2019 Jul 24. PubMed |
| Construction of a mavs-inactivated MDCK cell line for facilitating the propagation of canine distemper virus (CDV). Cai C, Wang X, Zhao Y, Yi C, Jin Z, Zhang A, Han L. Mol Immunol. 2019 Oct;114:133-138. doi: 10.1016/j.molimm.2019.06.013. Epub 2019 Jul 25. PubMed |
| Structural Basis for Target-Directed MicroRNA Degradation. Sheu-Gruttadauria J, Pawlica P, Klum SM, Wang S, Yario TA, Schirle Oakdale NT, Steitz JA, MacRae IJ. Mol Cell. 2019 Sep 19;75(6):1243-1255.e7. doi: 10.1016/j.molcel.2019.06.019. Epub 2019 Jul 25. PubMed |
| Bilirubin Links Heme Metabolism to Neuroprotection by Scavenging Superoxide. Vasavda C, Kothari R, Malla AP, Tokhunts R, Lin A, Ji M, Ricco C, Xu R, Saavedra HG, Sbodio JI, Snowman AM, Albacarys L, Hester L, Sedlak TW, Paul BD, Snyder SH. Cell Chem Biol. 2019 Oct 17;26(10):1450-1460.e7. doi: 10.1016/j.chembiol.2019.07.006. Epub 2019 Jul 25. PubMed |
| TREM1/3 Deficiency Impairs Tissue Repair After Acute Kidney Injury and Mitochondrial Metabolic Flexibility in Tubular Epithelial Cells. Tammaro A, Scantlebery AML, Rampanelli E, Borrelli C, Claessen N, Butter LM, Soriani A, Colonna M, Leemans JC, Dessing MC, Florquin S. Front Immunol. 2019 Jul 9;10:1469. doi: 10.3389/fimmu.2019.01469. eCollection 2019. PubMed |
| Regulatory mechanisms for the axonal localization of tau protein in neurons. Iwata M, Watanabe S, Yamane A, Miyasaka T, Misonou H. Mol Biol Cell. 2019 Sep 1;30(19):2441-2457. doi: 10.1091/mbc.E19-03-0183. Epub 2019 Aug 7. PubMed |
| ESCRT-mediated phagophore sealing during mitophagy. Zhen Y, Spangenberg H, Munson MJ, Brech A, Schink KO, Tan KW, Sorensen V, Wenzel EM, Radulovic M, Engedal N, Simonsen A, Raiborg C, Stenmark H. Autophagy. 2019 Aug 1:1-16. doi: 10.1080/15548627.2019.1639301. PubMed |
| Mapping cis-regulatory chromatin contacts in neural cells links neuropsychiatric disorder risk variants to target genes. Song M, Yang X, Ren X, Maliskova L, Li B, Jones IR, Wang C, Jacob F, Wu K, Traglia M, Tam TW, Jamieson K, Lu SY, Ming GL, Li Y, Yao J, Weiss LA, Dixon JR, Judge LM, Conklin BR, Song H, Gan L, Shen Y. Nat Genet. 2019 Aug;51(8):1252-1262. doi: 10.1038/s41588-019-0472-1. Epub 2019 Jul 31. PubMed |
| SALM1 controls synapse development by promoting F-actin/PIP2-dependent Neurexin clustering. Brouwer M, Farzana F, Koopmans F, Chen N, Brunner JW, Oldani S, Li KW, van Weering JR, Smit AB, Toonen RF, Verhage M. EMBO J. 2019 Sep 2;38(17):e101289. doi: 10.15252/embj.2018101289. Epub 2019 Aug 1. PubMed |
| Novel p97/VCP inhibitor induces endoplasmic reticulum stress and apoptosis in both bortezomib-sensitive and -resistant multiple myeloma cells. Nishimura N, Radwan MO, Amano M, Endo S, Fujii E, Hayashi H, Ueno S, Ueno N, Tatetsu H, Hata H, Okamoto Y, Otsuka M, Mitsuya H, Matsuoka M, Okuno Y. Cancer Sci. 2019 Oct;110(10):3275-3287. doi: 10.1111/cas.14154. Epub 2019 Aug 14. PubMed |
| A molecular triage process mediated by RING finger protein 126 and BCL2-associated athanogene 6 regulates degradation of G0/G1 switch gene 2. Kamikubo K, Kato H, Kioka H, Yamazaki S, Tsukamoto O, Nishida Y, Asano Y, Imamura H, Kawahara H, Shintani Y, Takashima S. J Biol Chem. 2019 Oct 4;294(40):14562-14573. doi: 10.1074/jbc.RA119.008544. Epub 2019 Aug 1. PubMed |
| Ifit1 regulates norovirus infection and enhances the interferon response in murine macrophage-like cells. Mears HV, Emmott E, Chaudhry Y, Hosmillo M, Goodfellow IG, Sweeney TR. Wellcome Open Res. 2019 May 15;4:82. doi: 10.12688/wellcomeopenres.15223.1. eCollection 2019. PubMed |
| Heterozygous Mutations in SMARCA2 Reprogram the Enhancer Landscape by Global Retargeting of SMARCA4. Gao F, Elliott NJ, Ho J, Sharp A, Shokhirev MN, Hargreaves DC. Mol Cell. 2019 Sep 5;75(5):891-904.e7. doi: 10.1016/j.molcel.2019.06.024. Epub 2019 Jul 30. PubMed |
| Innate Immune Response to Influenza Virus at Single-Cell Resolution in Human Epithelial Cells Revealed Paracrine Induction of Interferon Lambda 1. Ramos I, Smith G, Ruf-Zamojski F, Martinez-Romero C, Fribourg M, Carbajal EA, Hartmann BM, Nair VD, Marjanovic N, Monteagudo PL, DeJesus VA, Mutetwa T, Zamojski M, Tan GS, Jayaprakash C, Zaslavsky E, Albrecht RA, Sealfon SC, Garcia-Sastre A, Fernandez-Sesma A. J Virol. 2019 Sep 30;93(20). pii: JVI.00559-19. doi: 10.1128/JVI.00559-19. Print 2019 Oct 15. PubMed |
| Kaposi's Sarcoma-Associated Herpesvirus Lytic Replication Interferes with mTORC1 Regulation of Autophagy and Viral Protein Synthesis. Pringle ES, Robinson CA, McCormick C. J Virol. 2019 Oct 15;93(21). pii: JVI.00854-19. doi: 10.1128/JVI.00854-19. Print 2019 Nov 1. PubMed |
| CRISPR-based genomic loci labeling revealed ordered spatial organization of chromatin in living diploid human cells. Guo DG, Wang DB, Liu C, Lu S, Hou Y, Zhang XE. Biochim Biophys Acta Mol Cell Res. 2019 Dec;1866(12):118518. doi: 10.1016/j.bbamcr.2019.07.013. Epub 2019 Jul 31. PubMed |
| Coagulant activity of recombinant human factor VII produced by lentiviral human F7 gene transfer in immortalized hepatocyte-like cell line. Pongjantarasatian S, Kadegasem P, Sasanakul W, Sa-Ngiamsuntorn K, Borwornpinyo S, Sirachainan N, Chuansumrit A, Tanratana P, Hongeng S. PLoS One. 2019 Aug 5;14(8):e0220825. doi: 10.1371/journal.pone.0220825. eCollection 2019. PubMed |
| Elevated UCP1 levels are sufficient to improve glucose uptake in human white adipocytes. Tews D, Pula T, Funcke JB, Jastroch M, Keuper M, Debatin KM, Wabitsch M, Fischer-Posovszky P. Redox Biol. 2019 Sep;26:101286. doi: 10.1016/j.redox.2019.101286. Epub 2019 Jul 27. PubMed |
| The Kaposi's Sarcoma-Associated Herpesvirus Protein ORF42 Is Required for Efficient Virion Production and Expression of Viral Proteins. Butnaru M, Gaglia MM. Viruses. 2019 Aug 2;11(8). pii: v11080711. doi: 10.3390/v11080711. PubMed |
| 3D bioprinted endometrial stem cells on melt electrospun poly epsilon-caprolactone mesh for pelvic floor application promote anti-inflammatory responses in mice. Paul K, Darzi S, McPhee G, Del Borgo MP, Werkmeister JA, Gargett CE, Mukherjee S. Acta Biomater. 2019 Oct 1;97:162-176. doi: 10.1016/j.actbio.2019.08.003. Epub 2019 Aug 3. PubMed |
| SAMHD1 Regulates Human Papillomavirus 16-Induced Cell Proliferation and Viral Replication during Differentiation of Keratinocytes. James CD, Prabhakar AT, Otoa R, Evans MR, Wang X, Bristol ML, Zhang K, Li R, Morgan IM. mSphere. 2019 Aug 7;4(4). pii: 4/4/e00448-19. doi: 10.1128/mSphere.00448-19. PubMed |
| PORCN inhibition synergizes with PI3K/mTOR inhibition in Wnt-addicted cancers. Zhong Z, Sepramaniam S, Chew XH, Wood K, Lee MA, Madan B, Virshup DM. Oncogene. 2019 Oct;38(40):6662-6677. doi: 10.1038/s41388-019-0908-1. Epub 2019 Aug 7. PubMed |
| Hotspot SF3B1 mutations induce metabolic reprogramming and vulnerability to serine deprivation. Dalton WB, Helmenstine E, Walsh N, Gondek LP, Kelkar DS, Read A, Natrajan R, Christenson ES, Roman B, Das S, Zhao L, Leone RD, Shinn D, Groginski T, Madugundu AK, Patil A, Zabransky DJ, Medford A, Lee J, Cole AJ, Rosen M, Thakar M, Ambinder A, Donaldson J, DeZern AE, Cravero K, Chu D, Madero-Marroquin R, Pandey A, Hurley PJ, Lauring J, Park BH. J Clin Invest. 2019 Aug 8;130:4708-4723. doi: 10.1172/JCI125022. PubMed |
| Dephosphorylation activates the interferon-stimulated Schlafen family member 11 in the DNA damage response. Malone D, Lardelli RM, Li M, David M. J Biol Chem. 2019 Oct 4;294(40):14674-14685. doi: 10.1074/jbc.RA118.006588. Epub 2019 Aug 8. PubMed |
| Structural basis for AcrVA4 inhibition of specific CRISPR-Cas12a. Knott GJ, Cress BF, Liu JJ, Thornton BW, Lew RJ, Al-Shayeb B, Rosenberg DJ, Hammel M, Adler BA, Lobba MJ, Xu M, Arkin AP, Fellmann C, Doudna JA. Elife. 2019 Aug 9;8. pii: 49110. doi: 10.7554/eLife.49110. PubMed |
| USP49 potently stabilizes APOBEC3G protein by removing ubiquitin and inhibits HIV-1 replication. Pan T, Song Z, Wu L, Liu G, Ma X, Peng Z, Zhou M, Liang L, Liu B, Liu J, Zhang J, Zhang X, Huang R, Zhao J, Li Y, Ling X, Luo Y, Tang X, Cai W, Deng K, Li L, Zhang H. Elife. 2019 Aug 9;8. pii: 48318. doi: 10.7554/eLife.48318. PubMed |
| KH-Type Splicing Regulatory Protein Controls Colorectal Cancer Cell Growth and Modulates the Tumor Microenvironment. Caiazza F, Oficjalska K, Tosetto M, Phelan JJ, Noonan S, Martin P, Killick K, Breen L, O'Neill F, Nolan B, Furney S, Power R, Fennelly D, Craik CS, O'Sullivan J, Sheahan K, Doherty GA, Ryan EJ. Am J Pathol. 2019 Oct;189(10):1916-1932. doi: 10.1016/j.ajpath.2019.07.004. Epub 2019 Aug 9. PubMed |
| CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan. Vennin C, Melenec P, Rouet R, Nobis M, Cazet AS, Murphy KJ, Herrmann D, Reed DA, Lucas MC, Warren SC, Elgundi Z, Pinese M, Kalna G, Roden D, Samuel M, Zaratzian A, Grey ST, Da Silva A, Leung W, Mathivanan S, Wang Y, Braithwaite AW, Christ D, Benda A, Parkin A, Phillips PA, Whitelock JM, Gill AJ, Sansom OJ, Croucher DR, Parker BL, Pajic M, Morton JP, Cox TR, Timpson P. Nat Commun. 2019 Aug 12;10(1):3637. doi: 10.1038/s41467-019-10968-6. PubMed |
| The Hippo pathway modulates resistance to BET proteins inhibitors in lung cancer cells. Gobbi G, Donati B, Do Valle IF, Reggiani F, Torricelli F, Remondini D, Castellani G, Ambrosetti DC, Ciarrocchi A, Sancisi V. Oncogene. 2019 Oct;38(42):6801-6817. doi: 10.1038/s41388-019-0924-1. Epub 2019 Aug 12. PubMed |
| MRTF-A controls myofibroblastic differentiation of human multipotent stromal cells and their tumour-supporting function in xenograft models. Werner S, Lutzkendorf J, Muller T, Muller LP, Posern G. Sci Rep. 2019 Aug 13;9(1):11725. doi: 10.1038/s41598-019-48142-z. PubMed |
| MRP4 sustains Wnt/beta-catenin signaling for pregnancy, endometriosis and endometrial cancer. Chen JJ, Xiao ZJ, Meng X, Wang Y, Yu MK, Huang WQ, Sun X, Chen H, Duan YG, Jiang X, Wong MP, Chan HC, Zou F, Ruan YC. Theranostics. 2019 Jul 9;9(17):5049-5064. doi: 10.7150/thno.32097. eCollection 2019. PubMed |
| The long noncoding RNA CHROME regulates cholesterol homeostasis in primate. Hennessy EJ, van Solingen C, Scacalossi KR, Ouimet M, Afonso MS, Prins J, Koelwyn GJ, Sharma M, Ramkhelawon B, Carpenter S, Busch A, Chernogubova E, Matic LP, Hedin U, Maegdefessel L, Caffrey BE, Hussein MA, Ricci EP, Temel RE, Garabedian MJ, Berger JS, Vickers KC, Kanke M, Sethupathy P, Teupser D, Holdt LM, Moore KJ. Nat Metab. 2019 Jan;1(1):98-110. doi: 10.1038/s42255-018-0004-9. Epub 2018 Dec 3. PubMed |
| p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas. Hsieh MH, Choe JH, Gadhvi J, Kim YJ, Arguez MA, Palmer M, Gerold H, Nowak C, Do H, Mazambani S, Knighton JK, Cha M, Goodwin J, Kang MK, Jeong JY, Lee SY, Faubert B, Xuan Z, Abel ED, Scafoglio C, Shackelford DB, Minna JD, Singh PK, Shulaev V, Bleris L, Hoyt K, Kim J, Inoue M, DeBerardinis RJ, Kim TH, Kim JW. Cell Rep. 2019 Aug 13;28(7):1860-1878.e9. doi: 10.1016/j.celrep.2019.07.027. PubMed |
| A CEP104-CSPP1 Complex Is Required for Formation of Primary Cilia Competent in Hedgehog Signaling. Frikstad KM, Molinari E, Thoresen M, Ramsbottom SA, Hughes F, Letteboer SJF, Gilani S, Schink KO, Stokke T, Geimer S, Pedersen LB, Giles RH, Akhmanova A, Roepman R, Sayer JA, Patzke S. Cell Rep. 2019 Aug 13;28(7):1907-1922.e6. doi: 10.1016/j.celrep.2019.07.025. PubMed |
| A New MicroRNA Cluster Involved in the Reprogramming to a Pluripotent State. Sherstyuk VV, Davletshina GI, Vyatkin YV, Shtokalo DN, Vlasov VV, Zakian SM. Acta Naturae. 2019 Apr-Jun;11(2):92-97. doi: 10.32607/20758251-2019-11-2-92-97. PubMed |
| Epitranscriptomic Addition of m(5)C to HIV-1 Transcripts Regulates Viral Gene Expression. Courtney DG, Tsai K, Bogerd HP, Kennedy EM, Law BA, Emery A, Swanstrom R, Holley CL, Cullen BR. Cell Host Microbe. 2019 Aug 14;26(2):217-227.e6. doi: 10.1016/j.chom.2019.07.005. PubMed |
| TRPC6 Binds to and Activates Calpain, Independent of Its Channel Activity, and Regulates Podocyte Cytoskeleton, Cell Adhesion, and Motility. Farmer LK, Rollason R, Whitcomb DJ, Ni L, Goodliff A, Lay AC, Birnbaumer L, Heesom KJ, Xu SZ, Saleem MA, Welsh GI. J Am Soc Nephrol. 2019 Oct;30(10):1910-1924. doi: 10.1681/ASN.2018070729. Epub 2019 Aug 15. PubMed |
| The synthesis of branched-chain fatty acids is limited by enzymatic decarboxylation of ethyl- and methylmalonyl-CoA. Dewulf JP, Gerin I, Rider MH, Veiga-da-Cunha M, Van Schaftingen E, Bommer GT. Biochem J. 2019 Aug 30;476(16):2427-2447. doi: 10.1042/BCJ20190500. PubMed |
| CXCL14 suppresses human papillomavirus-associated head and neck cancer through antigen-specific CD8(+) T-cell responses by upregulating MHC-I expression. Westrich JA, Vermeer DW, Silva A, Bonney S, Berger JN, Cicchini L, Greer RO, Song JI, Raben D, Slansky JE, Lee JH, Spanos WC, Pyeon D. Oncogene. 2019 Nov;38(46):7166-7180. doi: 10.1038/s41388-019-0911-6. Epub 2019 Aug 15. PubMed |
| Cancer Cell-targeted and Activatable Photoimmunotherapy Spares T Cells in a 3D Coculture Model. Kercher EM, Nath S, Rizvi I, Spring BQ. Photochem Photobiol. 2019 Aug 19. doi: 10.1111/php.13153. PubMed |
| Systematic characterization of BAF mutations provides insights into intracomplex synthetic lethalities in human cancers. Schick S, Rendeiro AF, Runggatscher K, Ringler A, Boidol B, Hinkel M, Majek P, Vulliard L, Penz T, Parapatics K, Schmidl C, Menche J, Boehmelt G, Petronczki M, Muller AC, Bock C, Kubicek S. Nat Genet. 2019 Sep;51(9):1399-1410. doi: 10.1038/s41588-019-0477-9. Epub 2019 Aug 19. PubMed |
| Toll-like receptor mediated inflammation requires FASN-dependent MYD88 palmitoylation. Kim YC, Lee SE, Kim SK, Jang HD, Hwang I, Jin S, Hong EB, Jang KS, Kim HS. Nat Chem Biol. 2019 Sep;15(9):907-916. doi: 10.1038/s41589-019-0344-0. Epub 2019 Aug 19. PubMed |
| Essential thrombocytosis attributed to JAK2-T875N germline mutation. Yoshimitsu M, Hachiman M, Uchida Y, Arima N, Arai A, Kamada Y, Shide K, Ito M, Shimoda K, Ishitsuka K. Int J Hematol. 2019 Nov;110(5):584-590. doi: 10.1007/s12185-019-02725-8. Epub 2019 Aug 19. PubMed |
| Genomic Resolution of DLX-Orchestrated Transcriptional Circuits Driving Development of Forebrain GABAergic Neurons. Lindtner S, Catta-Preta R, Tian H, Su-Feher L, Price JD, Dickel DE, Greiner V, Silberberg SN, McKinsey GL, McManus MT, Pennacchio LA, Visel A, Nord AS, Rubenstein JLR. Cell Rep. 2019 Aug 20;28(8):2048-2063.e8. doi: 10.1016/j.celrep.2019.07.022. PubMed |
| Identification of an ATP-sensitive potassium channel in mitochondria. Paggio A, Checchetto V, Campo A, Menabo R, Di Marco G, Di Lisa F, Szabo I, Rizzuto R, De Stefani D. Nature. 2019 Aug;572(7771):609-613. doi: 10.1038/s41586-019-1498-3. Epub 2019 Aug 21. PubMed |
| Identifying chemogenetic interactions from CRISPR screens with drugZ. Colic M, Wang G, Zimmermann M, Mascall K, McLaughlin M, Bertolet L, Lenoir WF, Moffat J, Angers S, Durocher D, Hart T. Genome Med. 2019 Aug 22;11(1):52. doi: 10.1186/s13073-019-0665-3. PubMed |
| Plasticity of the Cullin-RING Ligase Repertoire Shapes Sensitivity to Ligand-Induced Protein Degradation. Mayor-Ruiz C, Jaeger MG, Bauer S, Brand M, Sin C, Hanzl A, Mueller AC, Menche J, Winter GE. Mol Cell. 2019 Aug 22;75(4):849-858.e8. doi: 10.1016/j.molcel.2019.07.013. PubMed |
| A Tag-Based Affinity Purification Mass Spectrometry Workflow for Systematic Isolation of the Human Mitochondrial Protein Complexes. Wu Z, Malty R, Moutaoufik MT, Zhang Q, Jessulat M, Babu M. Adv Exp Med Biol. 2019;1158:83-100. doi: 10.1007/978-981-13-8367-0_6. PubMed |
| Albumin evokes Ca(2+)-induced cell oxidative stress and apoptosis through TRPM2 channel in renal collecting duct cells reduced by curcumin. Naziroglu M, Cig B, Yazgan Y, Schwaerzer GK, Theilig F, Pecze L. Sci Rep. 2019 Aug 27;9(1):12403. doi: 10.1038/s41598-019-48716-x. PubMed |
| ZNNT1 long noncoding RNA induces autophagy to inhibit tumorigenesis of uveal melanoma by regulating key autophagy gene expression. Li P, He J, Yang Z, Ge S, Zhang H, Zhong Q, Fan X. Autophagy. 2019 Sep 3:1-14. doi: 10.1080/15548627.2019.1659614. PubMed |
| WNT5B governs the phenotype of basal-like breast cancer by activating WNT signaling. Jiang S, Zhang M, Zhang Y, Zhou W, Zhu T, Ruan Q, Chen H, Fang J, Zhou F, Sun J, Yang X. Cell Commun Signal. 2019 Aug 28;17(1):109. doi: 10.1186/s12964-019-0419-2. PubMed |
| Concomitant targeting of Hedgehog signaling and MCL-1 synergistically induces cell death in Hedgehog-driven cancer cells. Meister MT, Boedicker C, Linder B, Kogel D, Klingebiel T, Fulda S. Cancer Lett. 2019 Nov 28;465:1-11. doi: 10.1016/j.canlet.2019.08.012. Epub 2019 Aug 26. PubMed |
| Tanycytic TSPO inhibition induces lipophagy to regulate lipid metabolism and improve energy balance. Kim S, Kim N, Park S, Jeon Y, Lee J, Yoo SJ, Lee JW, Moon C, Yu SW, Kim EK. Autophagy. 2019 Aug 30:1-21. doi: 10.1080/15548627.2019.1659616. PubMed |
| Differential Activation of the Transcription Factor IRF1 Underlies the Distinct Immune Responses Elicited by Type I and Type III Interferons. Forero A, Ozarkar S, Li H, Lee CH, Hemann EA, Nadjsombati MS, Hendricks MR, So L, Green R, Roy CN, Sarkar SN, von Moltke J, Anderson SK, Gale M Jr, Savan R. Immunity. 2019 Sep 17;51(3):451-464.e6. doi: 10.1016/j.immuni.2019.07.007. Epub 2019 Aug 27. PubMed |
| Poly(ADP-Ribose) Polymerase 2 Recruits Replication Protein A to Sites of LINE-1 Integration to Facilitate Retrotransposition. Miyoshi T, Makino T, Moran JV. Mol Cell. 2019 Sep 19;75(6):1286-1298.e12. doi: 10.1016/j.molcel.2019.07.018. Epub 2019 Aug 28. PubMed |
| Sema3a-Nrp1 Signaling Mediates Fast-Twitch Myofiber Specificity of Tw2(+) Cells. Li S, Karri D, Sanchez-Ortiz E, Jaichander P, Bassel-Duby R, Liu N, Olson EN. Dev Cell. 2019 Oct 7;51(1):89-98.e4. doi: 10.1016/j.devcel.2019.08.002. Epub 2019 Aug 29. PubMed |
| Centrosome loss results in an unstable genome and malignant prostate tumors. Wang M, Nagle RB, Knudsen BS, Cress AE, Rogers GC. Oncogene. 2020 Jan;39(2):399-413. doi: 10.1038/s41388-019-0995-z. Epub 2019 Sep 2. PubMed |
| FAK activity sustains intrinsic and acquired ovarian cancer resistance to platinum chemotherapy. Diaz Osterman CJ, Ozmadenci D, Kleinschmidt EG, Taylor KN, Barrie AM, Jiang S, Bean LM, Sulzmaier FJ, Jean C, Tancioni I, Anderson K, Uryu S, Cordasco EA, Li J, Chen XL, Fu G, Ojalill M, Rappu P, Heino J, Mark AM, Xu G, Fisch KM, Kolev VN, Weaver DT, Pachter JA, Gyorffy B, McHale MT, Connolly DC, Molinolo A, Stupack DG, Schlaepfer DD. Elife. 2019 Sep 3;8. pii: 47327. doi: 10.7554/eLife.47327. PubMed |
| MicroRNA-138 is a Prognostic Biomarker for Triple-Negative Breast Cancer and Promotes Tumorigenesis via TUSC2 repression. Nama S, Muhuri M, Di Pascale F, Quah S, Aswad L, Fullwood M, Sampath P. Sci Rep. 2019 Sep 3;9(1):12718. doi: 10.1038/s41598-019-49155-4. PubMed |
| Residual apoptotic activity of a tumorigenic p53 mutant improves cancer therapy responses. Timofeev O, Klimovich B, Schneikert J, Wanzel M, Pavlakis E, Noll J, Mutlu S, Elmshauser S, Nist A, Mernberger M, Lamp B, Wenig U, Brobeil A, Gattenlohner S, Kohler K, Stiewe T. EMBO J. 2019 Oct 15;38(20):e102096. doi: 10.15252/embj.2019102096. Epub 2019 Sep 4. PubMed |
| Proteomic Analysis Identifies Membrane Proteins Dependent on the ER Membrane Protein Complex. Tian S, Wu Q, Zhou B, Choi MY, Ding B, Yang W, Dong M. Cell Rep. 2019 Sep 3;28(10):2517-2526.e5. doi: 10.1016/j.celrep.2019.08.006. PubMed |
| B7-H3 as a Novel CAR-T Therapeutic Target for Glioblastoma. Tang X, Zhao S, Zhang Y, Wang Y, Zhang Z, Yang M, Zhu Y, Zhang G, Guo G, Tong A, Zhou L. Mol Ther Oncolytics. 2019 Jul 23;14:279-287. doi: 10.1016/j.omto.2019.07.002. eCollection 2019 Sep 27. PubMed |
| mTORC1 Activation Requires DRAM-1 by Facilitating Lysosomal Amino Acid Efflux. Beaumatin F, O'Prey J, Barthet VJA, Zunino B, Parvy JP, Bachmann AM, O'Prey M, Kania E, Gonzalez PS, Macintosh R, Lao LY, Nixon C, Lopez J, Long JS, Tait SWG, Ryan KM. Mol Cell. 2019 Oct 3;76(1):163-176.e8. doi: 10.1016/j.molcel.2019.07.021. Epub 2019 Sep 3. PubMed |
| SOX11 and SOX4 drive the reactivation of an embryonic gene program during murine wound repair. Miao Q, Hill MC, Chen F, Mo Q, Ku AT, Ramos C, Sock E, Lefebvre V, Nguyen H. Nat Commun. 2019 Sep 6;10(1):4042. doi: 10.1038/s41467-019-11880-9. PubMed |
| CYP1B1 prevents proteasome-mediated XIAP degradation by inducing PKCepsilon activation and phosphorylation of XIAP. Baek HS, Kwon YJ, Ye DJ, Cho E, Kwon TU, Chun YJ. Biochim Biophys Acta Mol Cell Res. 2019 Dec;1866(12):118553. doi: 10.1016/j.bbamcr.2019.118553. Epub 2019 Sep 4. PubMed |
| Downregulation of SIRT2 by Chronic Stress Reduces Expression of Synaptic Plasticity-related Genes through the Upregulation of Ehmt2. Wang SE, Ko SY, Jo S, Jo HR, Han J, Kim YS, Son H. Exp Neurobiol. 2019 Aug 31;28(4):537-546. doi: 10.5607/en.2019.28.4.537. PubMed |
| Generation of Knockout Human Primary Keratinocytes by CRISPR/Cas9. Grossi S, Fenini G, Hennig P, Di Filippo M, Beer HD. Methods Mol Biol. 2019 Sep 10. doi: 10.1007/7651_2019_262. PubMed |
| Microglial Pro-Inflammatory and Anti-Inflammatory Phenotypes Are Modulated by Translocator Protein Activation. Pozzo ED, Tremolanti C, Costa B, Giacomelli C, Milenkovic VM, Bader S, Wetzel CH, Rupprecht R, Taliani S, Settimo FD, Martini C. Int J Mol Sci. 2019 Sep 10;20(18). pii: ijms20184467. doi: 10.3390/ijms20184467. PubMed |
| Genetic heterogeneity within collective invasion packs drives leader and follower cell phenotypes. Zoeller EL, Pedro B, Konen J, Dwivedi B, Rupji M, Sundararaman N, Wang L, Horton JR, Zhong C, Barwick BG, Cheng X, Martinez ED, Torres MP, Kowalski J, Marcus AI, Vertino PM. J Cell Sci. 2019 Oct 9;132(19). pii: jcs.231514. doi: 10.1242/jcs.231514. PubMed |
| Crth2 receptor signaling down-regulates lipopolysaccharide-induced NF-kappaB activation in murine macrophages via changes in intracellular calcium. Diwakar BT, Yoast R, Nettleford S, Qian F, Lee TJ, Berry S, Huffnagle I, Rossi RM, Trebak M, Paulson RF, Prabhu KS. FASEB J. 2019 Nov;33(11):12838-12852. doi: 10.1096/fj.201802608R. Epub 2019 Sep 13. PubMed |
| Circadian gene PER1 senses progesterone signal during human endometrial decidualization. Zhang Y, Meng N, Bao H, Jiang Y, Yang N, Wu K, Wu J, Wang H, Kong S, Zhang Y. J Endocrinol. 2019 Sep 1. pii: JOE-19-0284.R2. doi: 10.1530/JOE-19-0284. PubMed |
| Intraneuronal Tau Misfolding Induced by Extracellular Amyloid-beta Oligomers. Rudenko LK, Wallrabe H, Periasamy A, Siller KH, Svindrych Z, Seward ME, Best MN, Bloom GS. J Alzheimers Dis. 2019;71(4):1125-1138. doi: 10.3233/JAD-190226. PubMed |
| TRP14 promotes resistance to cisplatin by inducing autophagy in ovarian cancer. Tan WX, Xu TM, Zhou ZL, Lv XJ, Liu J, Zhang WJ, Cui MH. Oncol Rep. 2019 Aug 2. doi: 10.3892/or.2019.7258. PubMed |
| Progenitor-derived human endothelial cells evade alloimmunity by CRISPR/Cas9-mediated complete ablation of MHC expression. Merola J, Reschke M, Pierce RW, Qin L, Spindler S, Baltazar T, Manes TD, Lopez-Giraldez F, Li G, Bracaglia LG, Xie C, Kirkiles-Smith N, Saltzman WM, Tietjen GT, Tellides G, Pober JS. JCI Insight. 2019 Oct 17;4(20). pii: 129739. doi: 10.1172/jci.insight.129739. PubMed |
| Regulation of VEGFR2 trafficking and signaling by Rab GTPase-activating proteins. Xie Y, Mansouri M, Rizk A, Berger P. Sci Rep. 2019 Sep 16;9(1):13342. doi: 10.1038/s41598-019-49646-4. PubMed |
| Improved GaLV-TR Glycoproteins to Pseudotype Lentiviral Vectors: Impact of Viral Protease Activity in the Production of LV Pseudotypes. Tomas HA, Mestre DA, Rodrigues AF, Guerreiro MR, Carrondo MJT, Coroadinha AS. Mol Ther Methods Clin Dev. 2019 Aug 14;15:1-8. doi: 10.1016/j.omtm.2019.08.001. eCollection 2019 Dec 13. PubMed |
| MRI Tracking of SPIO- and Fth1-Labeled Bone Marrow Mesenchymal Stromal Cell Transplantation for Treatment of Stroke. Huang X, Xue Y, Wu J, Zhan Q, Zhao J. Contrast Media Mol Imaging. 2019 Aug 29;2019:5184105. doi: 10.1155/2019/5184105. eCollection 2019. PubMed |
| Hepatitis C Virus Infection Is Inhibited by a Noncanonical Antiviral Signaling Pathway Targeted by NS3-NS4A. Vazquez C, Tan CY, Horner SM. J Virol. 2019 Nov 13;93(23). pii: JVI.00725-19. doi: 10.1128/JVI.00725-19. Print 2019 Dec 1. PubMed |
| Flow cytometry-based FRET identifies binding intensities in PPARgamma1 protein-protein interactions in living cells. Trumper V, von Knethen A, Preuss A, Ermilov E, Hackbarth S, Kuchler L, Gunne S, Schafer A, Bornhutter T, Vereb G, Ujlaky-Nagy L, Brune B, Roder B, Schindler M, Parnham MJ, Knape T. Theranostics. 2019 Jul 28;9(19):5444-5463. doi: 10.7150/thno.29367. eCollection 2019. PubMed |
| Mitochondrial protein import is regulated by p17/PERMIT to mediate lipid metabolism and cellular stress. Oleinik N, Kim J, Roth BM, Selvam SP, Gooz M, Johnson RH, Lemasters JJ, Ogretmen B. Sci Adv. 2019 Sep 11;5(9):eaax1978. doi: 10.1126/sciadv.aax1978. eCollection 2019 Sep. PubMed |
| Mitochondrial PE potentiates respiratory enzymes to amplify skeletal muscle aerobic capacity. Heden TD, Johnson JM, Ferrara PJ, Eshima H, Verkerke ARP, Wentzler EJ, Siripoksup P, Narowski TM, Coleman CB, Lin CT, Ryan TE, Reidy PT, de Castro Bras LE, Karner CM, Burant CF, Maschek JA, Cox JE, Mashek DG, Kardon G, Boudina S, Zeczycki TN, Rutter J, Shaikh SR, Vance JE, Drummond MJ, Neufer PD, Funai K. Sci Adv. 2019 Sep 11;5(9):eaax8352. doi: 10.1126/sciadv.aax8352. eCollection 2019 Sep. PubMed |
| Genetic determinants of cellular addiction to DNA polymerase theta. Feng W, Simpson DA, Carvajal-Garcia J, Price BA, Kumar RJ, Mose LE, Wood RD, Rashid N, Purvis JE, Parker JS, Ramsden DA, Gupta GP. Nat Commun. 2019 Sep 19;10(1):4286. doi: 10.1038/s41467-019-12234-1. PubMed |
| Ran pathway-independent regulation of mitotic Golgi disassembly by Importin-alpha. Chang CC, Chen CJ, Grauffel C, Pien YC, Lim C, Tsai SY, Hsia KC. Nat Commun. 2019 Sep 20;10(1):4307. doi: 10.1038/s41467-019-12207-4. PubMed |
| Tet inactivation disrupts YY1 binding and long-range chromatin interactions during embryonic heart development. Fang S, Li J, Xiao Y, Lee M, Guo L, Han W, Li T, Hill MC, Hong T, Mo W, Xu R, Zhang P, Wang F, Chang J, Zhou Y, Sun D, Martin JF, Huang Y. Nat Commun. 2019 Sep 20;10(1):4297. doi: 10.1038/s41467-019-12325-z. PubMed |
| Mitochondrial Reprogramming Underlies Resistance to BCL-2 Inhibition in Lymphoid Malignancies. Guieze R, Liu VM, Rosebrock D, Jourdain AA, Hernandez-Sanchez M, Martinez Zurita A, Sun J, Ten Hacken E, Baranowski K, Thompson PA, Heo JM, Cartun Z, Aygun O, Iorgulescu JB, Zhang W, Notarangelo G, Livitz D, Li S, Davids MS, Biran A, Fernandes SM, Brown JR, Lako A, Ciantra ZB, Lawlor MA, Keskin DB, Udeshi ND, Wierda WG, Livak KJ, Letai AG, Neuberg D, Harper JW, Carr SA, Piccioni F, Ott CJ, Leshchiner I, Johannessen CM, Doench J, Mootha VK, Getz G, Wu CJ. Cancer Cell. 2019 Oct 14;36(4):369-384.e13. doi: 10.1016/j.ccell.2019.08.005. Epub 2019 Sep 19. PubMed |
| Pooled CRISPR-Based Genetic Screens in Mammalian Cells. Chan K, Tong AHY, Brown KR, Mero P, Moffat J. J Vis Exp. 2019 Sep 4;(151). doi: 10.3791/59780. PubMed |
| CGGBP1 regulates CTCF occupancy at repeats. Patel D, Patel M, Datta S, Singh U. Epigenetics Chromatin. 2019 Sep 23;12(1):57. doi: 10.1186/s13072-019-0305-6. PubMed |
| Blockade of Glutathione Metabolism in IDH1-Mutated Glioma. Tang X, Fu X, Liu Y, Yu D, Cai SJ, Yang C. Mol Cancer Ther. 2020 Jan;19(1):221-230. doi: 10.1158/1535-7163.MCT-19-0103. Epub 2019 Sep 23. PubMed |
| High-throughput genome-wide phenotypic screening via immunomagnetic cell sorting. Mair B, Aldridge PM, Atwal RS, Philpott D, Zhang M, Masud SN, Labib M, Tong AHY, Sargent EH, Angers S, Moffat J, Kelley SO. Nat Biomed Eng. 2019 Oct;3(10):796-805. doi: 10.1038/s41551-019-0454-8. Epub 2019 Sep 23. PubMed |
ER-lysosome contacts enable cholesterol sensing by mTORC1 and drive aberrant growth signalling in Niemann-Pick type C.
Lim CY, Davis OB, Shin HR, Zhang J, Berdan CA, Jiang X, Counihan JL, Ory DS, Nomura DK, Zoncu R.
Nat Cell Biol. 2019 Oct;21(10):1206-1218. doi: 10.1038/s41556-019-0391-5. Epub 2019 Sep 23.
PubMed
Associated Plasmids |
| A genome-wide CRISPR screen identifies FBXO42 involvement in resistance toward MEK inhibition in NRAS-mutant melanoma. Nagler A, Vredevoogd DW, Alon M, Cheng PF, Trabish S, Kalaora S, Arafeh R, Goldin V, Levesque MP, Peeper DS, Samuels Y. Pigment Cell Melanoma Res. 2020 Mar;33(2):334-344. doi: 10.1111/pcmr.12825. Epub 2019 Oct 10. PubMed |
| Genome-Wide CRISPR-Cas9 Screen Reveals Selective Vulnerability of ATRX-Mutant Cancers to WEE1 Inhibition. Liang J, Zhao H, Diplas BH, Liu S, Liu J, Wang D, Lu Y, Zhu Q, Wu J, Wang W, Yan H, Zeng YX, Wang X, Jiao Y. Cancer Res. 2020 Feb 1;80(3):510-523. doi: 10.1158/0008-5472.CAN-18-3374. Epub 2019 Sep 24. PubMed |
| BH3-only proteins target BCL-xL/MCL-1, not BAX/BAK, to initiate apoptosis. Huang K, O'Neill KL, Li J, Zhou W, Han N, Pang X, Wu W, Struble L, Borgstahl G, Liu Z, Zhang L, Luo X. Cell Res. 2019 Nov;29(11):942-952. doi: 10.1038/s41422-019-0231-y. Epub 2019 Sep 24. PubMed |
| Control over single-cell distribution of G1 lengths by WNT governs pluripotency. Jang J, Han D, Golkaram M, Audouard M, Liu G, Bridges D, Hellander S, Chialastri A, Dey SS, Petzold LR, Kosik KS. PLoS Biol. 2019 Sep 26;17(9):e3000453. doi: 10.1371/journal.pbio.3000453. eCollection 2019 Sep. PubMed |
| Protein phosphatase 2A controls ongoing DNA replication by binding to and regulating cell division cycle 45 (CDC45). Perl AL, O'Connor CM, Fa P, Mayca Pozo F, Zhang J, Zhang Y, Narla G. J Biol Chem. 2019 Nov 8;294(45):17043-17059. doi: 10.1074/jbc.RA119.010432. Epub 2019 Sep 27. PubMed |
| PRDM16 Maintains Homeostasis of the Intestinal Epithelium by Controlling Region-Specific Metabolism. Stine RR, Sakers AP, TeSlaa T, Kissig M, Stine ZE, Kwon CW, Cheng L, Lim HW, Kaestner KH, Rabinowitz JD, Seale P. Cell Stem Cell. 2019 Dec 5;25(6):830-845.e8. doi: 10.1016/j.stem.2019.08.017. Epub 2019 Sep 26. PubMed |
| Dynamic Incorporation of Histone H3 Variants into Chromatin Is Essential for Acquisition of Aggressive Traits and Metastatic Colonization. Gomes AP, Ilter D, Low V, Rosenzweig A, Shen ZJ, Schild T, Rivas MA, Er EE, McNally DR, Mutvei AP, Han J, Ou YH, Cavaliere P, Mullarky E, Nagiec M, Shin S, Yoon SO, Dephoure N, Massague J, Melnick AM, Cantley LC, Tyler JK, Blenis J. Cancer Cell. 2019 Oct 14;36(4):402-417.e13. doi: 10.1016/j.ccell.2019.08.006. Epub 2019 Sep 26. PubMed |
HIF-independent synthetic lethality between CDK4/6 inhibition and VHL loss across species.
Nicholson HE, Tariq Z, Housden BE, Jennings RB, Stransky LA, Perrimon N, Signoretti S, Kaelin WG Jr.
Sci Signal. 2019 Oct 1;12(601). pii: 12/601/eaay0482. doi: 10.1126/scisignal.aay0482.
PubMed
Associated Plasmids |
| Epigenetic Suppression of Interferon Lambda Receptor Expression Leads to Enhanced Human Norovirus Replication In Vitro. Arthur SE, Sorgeloos F, Hosmillo M, Goodfellow IG. mBio. 2019 Oct 1;10(5). pii: mBio.02155-19. doi: 10.1128/mBio.02155-19. PubMed |
| Liver-Type Glutaminase GLS2 Is a Druggable Metabolic Node in Luminal-Subtype Breast Cancer. Lukey MJ, Cluntun AA, Katt WP, Lin MJ, Druso JE, Ramachandran S, Erickson JW, Le HH, Wang ZE, Blank B, Greene KS, Cerione RA. Cell Rep. 2019 Oct 1;29(1):76-88.e7. doi: 10.1016/j.celrep.2019.08.076. PubMed |
| A PINCH-1-Smurf1 signaling axis mediates mechano-regulation of BMPR2 and stem cell differentiation. Guo L, Wang R, Zhang K, Yuan J, Wang J, Wang X, Ma J, Wu C. J Cell Biol. 2019 Nov 4;218(11):3773-3794. doi: 10.1083/jcb.201902022. Epub 2019 Oct 2. PubMed |
Conserved CxnC motifs in Kaposi's sarcoma-associated herpesvirus ORF66 are required for viral late gene expression and are essential for its interaction with ORF34.
Didychuk AL, Castaneda AF, Kushnir LO, Huang CJ, Glaunsinger BA.
J Virol. 2019 Oct 2. pii: JVI.01299-19. doi: 10.1128/JVI.01299-19.
PubMed
Associated Plasmids |
| Characterization of HIV-1 CRF01_AE env Genes Derived from Recently Infected Indonesian Individuals. Sasaki M, Kotaki T, Khairunisa SQ, Tachibana S, Ophinni Y, Hayashi Y, Nasronudin, Kameoka M. AIDS Res Hum Retroviruses. 2019 Oct 3. doi: 10.1089/aid.2019.0179. PubMed |
| SEMA4C is a novel target to limit osteosarcoma growth, progression, and metastasis. Smeester BA, Slipek NJ, Pomeroy EJ, Bomberger HE, Shamsan GA, Peterson JJ, Crosby MR, Draper GM, Becklin KL, Rahrmann EP, McCarthy JB, Odde DJ, Wood DK, Largaespada DA, Moriarity BS. Oncogene. 2020 Jan;39(5):1049-1062. doi: 10.1038/s41388-019-1041-x. Epub 2019 Oct 3. PubMed |
| Essential role of glucokinase in the protection of pancreatic beta cells to the glucose energetic status. Marques P, Kamitz A, Bartolome A, Burillo J, Martinez H, Jimenez B, Fernandez-Rhodes M, Guillen C, Benito M. Cell Death Discov. 2019 Sep 30;5:138. doi: 10.1038/s41420-019-0219-x. eCollection 2019. PubMed |
| Neuromodulator Signaling Bidirectionally Controls Vesicle Numbers in Human Synapses. Patzke C, Brockmann MM, Dai J, Gan KJ, Grauel MK, Fenske P, Liu Y, Acuna C, Rosenmund C, Sudhof TC. Cell. 2019 Oct 3;179(2):498-513.e22. doi: 10.1016/j.cell.2019.09.011. PubMed |
Genetic modification of primary human B cells to model high-grade lymphoma.
Caeser R, Di Re M, Krupka JA, Gao J, Lara-Chica M, Dias JML, Cooke SL, Fenner R, Usheva Z, Runge HFP, Beer PA, Eldaly H, Pak HK, Park CS, Vassiliou GS, Huntly BJP, Mupo A, Bashford-Rogers RJM, Hodson DJ.
Nat Commun. 2019 Oct 4;10(1):4543. doi: 10.1038/s41467-019-12494-x.
PubMed
Associated Plasmids |
| TIMP3 expression associates with prognosis in colorectal cancer and its novel arylsulfonamide inducer, MPT0B390, inhibits tumor growth, metastasis and angiogenesis. Huang HL, Liu YM, Sung TY, Huang TC, Cheng YW, Liou JP, Pan SL. Theranostics. 2019 Sep 18;9(22):6676-6689. doi: 10.7150/thno.34020. eCollection 2019. PubMed |
| Stimulation of Piezo1 by mechanical signals promotes bone anabolism. Li X, Han L, Nookaew I, Mannen E, Silva MJ, Almeida M, Xiong J. Elife. 2019 Oct 7;8. pii: 49631. doi: 10.7554/eLife.49631. PubMed |
| Live Cell Imaging to Assess the Dynamics of Metaphase Timing and Cell Fate Following Mitotic Spindle Perturbations. Mercadante DL, Crowley EA, Manning AL. J Vis Exp. 2019 Sep 20;(151). doi: 10.3791/60255. PubMed |
Pyrin dephosphorylation is sufficient to trigger inflammasome activation in familial Mediterranean fever patients.
Magnotti F, Lefeuvre L, Benezech S, Malsot T, Waeckel L, Martin A, Kerever S, Chirita D, Desjonqueres M, Duquesne A, Gerfaud-Valentin M, Laurent A, Seve P, Popoff MR, Walzer T, Belot A, Jamilloux Y, Henry T.
EMBO Mol Med. 2019 Oct 7:e10547. doi: 10.15252/emmm.201910547.
PubMed
Associated Plasmids |
| L-type voltage-gated Ca(2+) channel CaV1.2 regulates chondrogenesis during limb development. Atsuta Y, Tomizawa RR, Levin M, Tabin CJ. Proc Natl Acad Sci U S A. 2019 Oct 22;116(43):21592-21601. doi: 10.1073/pnas.1908981116. Epub 2019 Oct 7. PubMed |
Mechanosensing during directed cell migration requires dynamic actin polymerization at focal adhesions.
Puleo JI, Parker SS, Roman MR, Watson AW, Eliato KR, Peng L, Saboda K, Roe DJ, Ros R, Gertler FB, Mouneimne G.
J Cell Biol. 2019 Oct 8. pii: jcb.201902101. doi: 10.1083/jcb.201902101.
PubMed
Associated Plasmids |
| Reduction of Global H3K27me(3) Enhances HER2/ErbB2 Targeted Therapy. Hirukawa A, Singh S, Wang J, Rennhack JP, Swiatnicki M, Sanguin-Gendreau V, Zuo D, Daldoul K, Lavoie C, Park M, Andrechek ER, Westbrook TF, Harris LN, Varadan V, Smith HW, Muller WJ. Cell Rep. 2019 Oct 8;29(2):249-257.e8. doi: 10.1016/j.celrep.2019.08.105. PubMed |
| Shank Proteins Couple the Endocytic Zone to the Postsynaptic Density to Control Trafficking and Signaling of Metabotropic Glutamate Receptor 5. Scheefhals N, Catsburg LAE, Westerveld ML, Blanpied TA, Hoogenraad CC, MacGillavry HD. Cell Rep. 2019 Oct 8;29(2):258-269.e8. doi: 10.1016/j.celrep.2019.08.102. PubMed |
| Chronic intermittent tachypacing by an optogenetic approach induces arrhythmia vulnerability in human engineered heart tissue. Lemme M, Braren I, Prondzynski M, Aksehirlioglu B, Ulmer BM, Schulze ML, Ismaili D, Meyer C, Hansen A, Christ T, Lemoine MD, Eschenhagen T. Cardiovasc Res. 2019 Oct 9. pii: 5584236. doi: 10.1093/cvr/cvz245. PubMed |
| Specific interactions of BCL-2 family proteins mediate sensitivity to BH3-mimetics in diffuse large B-cell lymphoma. Smith VM, Dietz A, Henz K, Bruecher D, Jackson R, Kowald L, van Wijk SJL, Jayne S, Macip S, Fulda S, Dyer MJS, Vogler M. Haematologica. 2019 Oct 10. pii: haematol.2019.220525. doi: 10.3324/haematol.2019.220525. PubMed |
| Therapeutic preferability of gemcitabine for ARID1A-deficient ovarian clear cell carcinoma. Kuroda T, Ogiwara H, Sasaki M, Takahashi K, Yoshida H, Kiyokawa T, Sudo K, Tamura K, Kato T, Okamoto A, Kohno T. Gynecol Oncol. 2019 Dec;155(3):489-498. doi: 10.1016/j.ygyno.2019.10.002. Epub 2019 Oct 8. PubMed |
| TFPa/HADHA is required for fatty acid beta-oxidation and cardiolipin re-modeling in human cardiomyocytes. Miklas JW, Clark E, Levy S, Detraux D, Leonard A, Beussman K, Showalter MR, Smith AT, Hofsteen P, Yang X, Macadangdang J, Manninen T, Raftery D, Madan A, Suomalainen A, Kim DH, Murry CE, Fiehn O, Sniadecki NJ, Wang Y, Ruohola-Baker H. Nat Commun. 2019 Oct 11;10(1):4671. doi: 10.1038/s41467-019-12482-1. PubMed |
| Profilin-Mediated Actin Allocation Regulates the Growth of Epithelial Microvilli. Faust JJ, Millis BA, Tyska MJ. Curr Biol. 2019 Oct 21;29(20):3457-3465.e3. doi: 10.1016/j.cub.2019.08.051. Epub 2019 Oct 10. PubMed |
| Individual cristae within the same mitochondrion display different membrane potentials and are functionally independent. Wolf DM, Segawa M, Kondadi AK, Anand R, Bailey ST, Reichert AS, van der Bliek AM, Shackelford DB, Liesa M, Shirihai OS. EMBO J. 2019 Nov 15;38(22):e101056. doi: 10.15252/embj.2018101056. Epub 2019 Oct 14. PubMed |
| Tumor-expressed B7-H3 mediates the inhibition of antitumor T-cell functions in ovarian cancer insensitive to PD-1 blockade therapy. Cai D, Li J, Liu D, Hong S, Qiao Q, Sun Q, Li P, Lyu N, Sun T, Xie S, Guo L, Ni L, Jin L, Dong C. Cell Mol Immunol. 2019 Oct 14. pii: 10.1038/s41423-019-0305-2. doi: 10.1038/s41423-019-0305-2. PubMed |
| Carboxypeptidase A6 Promotes the Proliferation and Migration of Hepatocellular Carcinoma by Up-regulating AKT Signaling Pathway. Huang QB, Zhang HW, Liao ZB. Curr Med Sci. 2019 Oct;39(5):727-733. doi: 10.1007/s11596-019-2098-z. Epub 2019 Oct 14. PubMed |
| Rare missense variants in the human cytosolic antibody receptor preserve antiviral function. Zeng J, Slodkowicz G, James LC. Elife. 2019 Oct 15;8. pii: 48339. doi: 10.7554/eLife.48339. PubMed |
| The ADP/ATP translocase drives mitophagy independent of nucleotide exchange. Hoshino A, Wang WJ, Wada S, McDermott-Roe C, Evans CS, Gosis B, Morley MP, Rathi KS, Li J, Li K, Yang S, McManus MJ, Bowman C, Potluri P, Levin M, Damrauer S, Wallace DC, Holzbaur ELF, Arany Z. Nature. 2019 Nov;575(7782):375-379. doi: 10.1038/s41586-019-1667-4. Epub 2019 Oct 16. PubMed |
| Inhibition of histone deacetylase 2 reduces MDM2 expression and reduces tumor growth in dedifferentiated liposarcoma. Seligson ND, Stets CW, Demoret BW, Awasthi A, Grosenbacher N, Shakya R, Hays JL, Chen JL. Oncotarget. 2019 Oct 1;10(55):5671-5679. doi: 10.18632/oncotarget.27144. eCollection 2019 Oct 1. PubMed |
| CircPLEKHM3 acts as a tumor suppressor through regulation of the miR-9/BRCA1/DNAJB6/KLF4/AKT1 axis in ovarian cancer. Zhang L, Zhou Q, Qiu Q, Hou L, Wu M, Li J, Li X, Lu B, Cheng X, Liu P, Lu W, Lu Y. Mol Cancer. 2019 Oct 17;18(1):144. doi: 10.1186/s12943-019-1080-5. PubMed |
| Direct RNA sequencing enables m(6)A detection in endogenous transcript isoforms at base-specific resolution. Lorenz DA, Sathe S, Einstein JM, Yeo GW. RNA. 2020 Jan;26(1):19-28. doi: 10.1261/rna.072785.119. Epub 2019 Oct 17. PubMed |
| The tumor suppressor TMEM127 regulates insulin sensitivity in a tissue-specific manner. Srikantan S, Deng Y, Cheng ZM, Luo A, Qin Y, Gao Q, Sande-Docor GM, Tao S, Zhang X, Harper N, Shannon CE, Fourcaudot M, Li Z, Kasinath BS, Harrison S, Ahuja S, Reddick RL, Dong LQ, Abdul-Ghani M, Norton L, Aguiar RCT, Dahia PLM. Nat Commun. 2019 Oct 17;10(1):4720. doi: 10.1038/s41467-019-12661-0. PubMed |
| Mammalian Surface Display Screening of Diverse Cystine-Dense Peptide Libraries for Difficult-to-Drug Targets. Crook ZR, Sevilla GP, Mhyre AJ, Olson JM. Methods Mol Biol. 2020;2070:363-396. doi: 10.1007/978-1-4939-9853-1_21. PubMed |
| MIGA2 Links Mitochondria, the ER, and Lipid Droplets and Promotes De Novo Lipogenesis in Adipocytes. Freyre CAC, Rauher PC, Ejsing CS, Klemm RW. Mol Cell. 2019 Dec 5;76(5):811-825.e14. doi: 10.1016/j.molcel.2019.09.011. Epub 2019 Oct 15. PubMed |
| MALT1 Phosphorylation Controls Activation of T Lymphocytes and Survival of ABC-DLBCL Tumor Cells. Gehring T, Erdmann T, Rahm M, Grass C, Flatley A, O'Neill TJ, Woods S, Meininger I, Karayel O, Kutzner K, Grau M, Shinohara H, Lammens K, Feederle R, Hauck SM, Lenz G, Krappmann D. Cell Rep. 2019 Oct 22;29(4):873-888.e10. doi: 10.1016/j.celrep.2019.09.040. PubMed |
| Exosome-Mediated MiR-155 Transfer Contributes to Hepatocellular Carcinoma Cell Proliferation by Targeting PTEN. Sun JF, Zhang D, Gao CJ, Zhang YW, Dai QS. Med Sci Monit Basic Res. 2019 Oct 24;25:218-228. doi: 10.12659/MSMBR.918134. PubMed |
| MYC predetermines the sensitivity of gastrointestinal cancer to antifolate drugs through regulating TYMS transcription. Liu T, Han Y, Yu C, Ji Y, Wang C, Chen X, Wang X, Shen J, Zhang Y, Lang JY. EBioMedicine. 2019 Oct;48:289-300. doi: 10.1016/j.ebiom.2019.10.003. Epub 2019 Oct 21. PubMed |
| Circular RNA circPICALM sponges miR-1265 to inhibit bladder cancer metastasis and influence FAK phosphorylation. Yan D, Dong W, He Q, Yang M, Huang L, Kong J, Qin H, Lin T, Huang J. EBioMedicine. 2019 Oct;48:316-331. doi: 10.1016/j.ebiom.2019.08.074. Epub 2019 Oct 21. PubMed |
Fate-mapping post-hypoxic tumor cells reveals a ROS-resistant phenotype that promotes metastasis.
Godet I, Shin YJ, Ju JA, Ye IC, Wang G, Gilkes DM.
Nat Commun. 2019 Oct 24;10(1):4862. doi: 10.1038/s41467-019-12412-1.
PubMed
Associated Plasmids |
| Phase separation-deficient TDP43 Schmidt. Nat Commun. 2019 PubMed |
| Pyridoxamine-phosphate oxidases and pyridoxamine-phosphate oxidase-related proteins catalyze the oxidation of 6-NAD(P)H to NAD(P). Marbaix AY, Chehade G, Noel G, Morsomme P, Vertommen D, Bommer GT, Van Schaftingen E. Biochem J. 2019 Oct 30;476(20):3033-3052. doi: 10.1042/BCJ20190602. PubMed |
| Promoter demethylation of the asparagine synthetase gene is required for ATF4-dependent adaptation to asparagine depletion. Jiang J, Srivastava S, Seim G, Pavlova NN, King B, Zou L, Zhang C, Zhong M, Feng H, Kapur R, Wek RC, Fan J, Zhang J. J Biol Chem. 2019 Dec 6;294(49):18674-18684. doi: 10.1074/jbc.RA119.010447. Epub 2019 Oct 28. PubMed |
| Nucleus pulposus primary cilia alter their length in response to changes in extracellular osmolarity but do not control TonEBP-mediated osmoregulation. Choi H, Madhu V, Shapiro IM, Risbud MV. Sci Rep. 2019 Oct 29;9(1):15469. doi: 10.1038/s41598-019-51939-7. PubMed |
| Postmortem Cortex Samples Identify Distinct Molecular Subtypes of ALS: Retrotransposon Activation, Oxidative Stress, and Activated Glia. Tam OH, Rozhkov NV, Shaw R, Kim D, Hubbard I, Fennessey S, Propp N, Fagegaltier D, Harris BT, Ostrow LW, Phatnani H, Ravits J, Dubnau J, Gale Hammell M. Cell Rep. 2019 Oct 29;29(5):1164-1177.e5. doi: 10.1016/j.celrep.2019.09.066. PubMed |
| USP7-Dependent Regulation of TRAF Activation and Signaling by a Viral Interferon Regulatory Factor Homologue. Xiang Q, Ju H, Nicholas J. J Virol. 2020 Jan 6;94(2). pii: JVI.01553-19. doi: 10.1128/JVI.01553-19. Print 2020 Jan 6. PubMed |
| Environmental enrichment prevents Abeta oligomer-induced synaptic dysfunction through mirna-132 and hdac3 signaling pathways. Wei Z, Meng X, El Fatimy R, Sun B, Mai D, Zhang J, Arora R, Zeng A, Xu P, Qu S, Krichevsky AM, Selkoe DJ, Li S. Neurobiol Dis. 2020 Feb;134:104617. doi: 10.1016/j.nbd.2019.104617. Epub 2019 Oct 24. PubMed |
| A missense mutation in SNRPE linked to non-syndromal microcephaly interferes with U snRNP assembly and pre-mRNA splicing. Chen T, Zhang B, Ziegenhals T, Prusty AB, Frohler S, Grimm C, Hu Y, Schaefke B, Fang L, Zhang M, Kraemer N, Kaindl AM, Fischer U, Chen W. PLoS Genet. 2019 Oct 31;15(10):e1008460. doi: 10.1371/journal.pgen.1008460. eCollection 2019 Oct. PubMed |
| Modulation of Calretinin Expression in Human Mesothelioma Cells Reveals the Implication of the FAK and Wnt Signaling Pathways in Conferring Chemoresistance towards Cisplatin. Worthmuller J, Salicio V, Oberson A, Blum W, Schwaller B. Int J Mol Sci. 2019 Oct 29;20(21). pii: ijms20215391. doi: 10.3390/ijms20215391. PubMed |
Oct4-mediated reprogramming induces embryonic-like microRNA expression signatures in human fibroblasts.
Peskova L, Cerna K, Oppelt J, Mraz M, Barta T.
Sci Rep. 2019 Oct 31;9(1):15759. doi: 10.1038/s41598-019-52294-3.
PubMed
Associated Plasmids |
| An anionic, endosome-escaping polymer to potentiate intracellular delivery of cationic peptides, biomacromolecules, and nanoparticles. Evans BC, Fletcher RB, Kilchrist KV, Dailing EA, Mukalel AJ, Colazo JM, Oliver M, Cheung-Flynn J, Brophy CM, Tierney JW, Isenberg JS, Hankenson KD, Ghimire K, Lander C, Gersbach CA, Duvall CL. Nat Commun. 2019 Nov 1;10(1):5012. doi: 10.1038/s41467-019-12906-y. PubMed |
| mTOR and autophagy pathways are dysregulated in murine and human models of Schaaf-Yang syndrome. Crutcher E, Pal R, Naini F, Zhang P, Laugsch M, Kim J, Bajic A, Schaaf CP. Sci Rep. 2019 Nov 4;9(1):15935. doi: 10.1038/s41598-019-52287-2. PubMed |
| Tumour exosomal CEMIP protein promotes cancer cell colonization in brain metastasis. Rodrigues G, Hoshino A, Kenific CM, Matei IR, Steiner L, Freitas D, Kim HS, Oxley PR, Scandariato I, Casanova-Salas I, Dai J, Badwe CR, Gril B, Tesic Mark M, Dill BD, Molina H, Zhang H, Benito-Martin A, Bojmar L, Ararso Y, Offer K, LaPlant Q, Buehring W, Wang H, Jiang X, Lu TM, Liu Y, Sabari JK, Shin SJ, Narula N, Ginter PS, Rajasekhar VK, Healey JH, Meylan E, Costa-Silva B, Wang SE, Rafii S, Altorki NK, Rudin CM, Jones DR, Steeg PS, Peinado H, Ghajar CM, Bromberg J, de Sousa M, Pisapia D, Lyden D. Nat Cell Biol. 2019 Nov;21(11):1403-1412. doi: 10.1038/s41556-019-0404-4. Epub 2019 Nov 4. PubMed |
| LCP1 triggers mTORC2/AKT activity and is pharmacologically targeted by enzastaurin in hypereosinophilia. Ma G, Gezer D, Herrmann O, Feldberg K, Schemionek M, Jawhar M, Reiter A, Brummendorf TH, Koschmieder S, Chatain N. Mol Carcinog. 2020 Jan;59(1):87-103. doi: 10.1002/mc.23131. Epub 2019 Nov 6. PubMed |
Negative regulation of autophagy by UBA6-BIRC6-mediated ubiquitination of LC3.
Jia R, Bonifacino JS.
Elife. 2019 Nov 6;8. pii: 50034. doi: 10.7554/eLife.50034.
PubMed
Associated Plasmids |
| Aryl Sulfonamides Degrade RBM39 and RBM23 by Recruitment to CRL4-DCAF15. Ting TC, Goralski M, Klein K, Wang B, Kim J, Xie Y, Nijhawan D. Cell Rep. 2019 Nov 5;29(6):1499-1510.e6. doi: 10.1016/j.celrep.2019.09.079. PubMed |
| Epigenetic regulation of microglial phosphatidylinositol 3-kinase pathway involved in long-term potentiation and synaptic plasticity in rats. Saw G, Krishna K, Gupta N, Soong TW, Mallilankaraman K, Sajikumar S, Dheen ST. Glia. 2020 Mar;68(3):656-669. doi: 10.1002/glia.23748. Epub 2019 Nov 8. PubMed |
| Regulation of CHD2 expression by the Chaserr long noncoding RNA gene is essential for viability. Rom A, Melamed L, Gil N, Goldrich MJ, Kadir R, Golan M, Biton I, Perry RB, Ulitsky I. Nat Commun. 2019 Nov 8;10(1):5092. doi: 10.1038/s41467-019-13075-8. PubMed |
| Rab8 GTPase regulates Klotho-mediated inhibition of cell growth and progression by directly modulating its surface expression in human non-small cell lung cancer. Chen B, Huang S, Pisanic Ii TR, Stark A, Tao Y, Cheng B, Li Y, Wei Y, Zhao W, Wang TH, Wu J. EBioMedicine. 2019 Nov;49:118-132. doi: 10.1016/j.ebiom.2019.10.040. Epub 2019 Nov 6. PubMed |
| Production of Lentivirus for the Establishment of CAR-T Cells. Lana MG, Strauss BE. Methods Mol Biol. 2020;2086:61-67. doi: 10.1007/978-1-0716-0146-4_4. PubMed |
| Protein targeting chimeric molecules specific for dual bromodomain 4 (BRD4) and Polo-like kinase 1 (PLK1) proteins in acute myeloid leukemia cells. Mu X, Bai L, Xu Y, Wang J, Lu H. Biochem Biophys Res Commun. 2020 Jan 22;521(4):833-839. doi: 10.1016/j.bbrc.2019.11.007. Epub 2019 Nov 7. PubMed |
| Cell-Cycle Asynchrony Generates DNA Damage at Mitotic Entry in Polyploid Cells. Nano M, Gemble S, Simon A, Pennetier C, Fraisier V, Marthiens V, Basto R. Curr Biol. 2019 Nov 18;29(22):3937-3945.e7. doi: 10.1016/j.cub.2019.09.041. Epub 2019 Nov 7. PubMed |
| Collagen IV (COL4A1, COL4A2), a Component of the Viral Biofilm, Is Induced by the HTLV-1 Oncoprotein Tax and Impacts Virus Transmission. Millen S, Gross C, Donhauser N, Mann MC, Peloponese JM Jr, Thoma-Kress AK. Front Microbiol. 2019 Oct 23;10:2439. doi: 10.3389/fmicb.2019.02439. eCollection 2019. PubMed |
| JAK2 (V617F) -Mediated Clonal Hematopoiesis Accelerates Pathological Remodeling in Murine Heart Failure. Sano S, Wang Y, Yura Y, Sano M, Oshima K, Yang Y, Katanasaka Y, Min KD, Matsuura S, Ravid K, Mohi G, Walsh K. JACC Basic Transl Sci. 2019 Sep 18;4(6):684-697. doi: 10.1016/j.jacbts.2019.05.013. eCollection 2019 Oct. PubMed |
| Dose-dependent activation of gene expression is achieved using CRISPR and small molecules that recruit endogenous chromatin machinery. Chiarella AM, Butler KV, Gryder BE, Lu D, Wang TA, Yu X, Pomella S, Khan J, Jin J, Hathaway NA. Nat Biotechnol. 2020 Jan;38(1):50-55. doi: 10.1038/s41587-019-0296-7. Epub 2019 Nov 11. PubMed |
| Transplantation of neural scaffolds consisting of dermal fibroblast-reprogrammed neurons and 3D silk fibrous materials promotes the repair of spinal cord injury. Hu Y, Zhang F, Zhong W, Liu Y, He Q, Yang M, Chen H, Xu X, Bian K, Xu J, Li J, Shen Y, Zhang H. J Mater Chem B. 2019 Dec 21;7(47):7525-7539. doi: 10.1039/c9tb01929d. Epub 2019 Nov 13. PubMed |
| Fanconi-BRCA pathway mutations in childhood T-cell acute lymphoblastic leukemia. Pouliot GP, Degar J, Hinze L, Kochupurakkal B, Vo CD, Burns MA, Moreau L, Ganesa C, Roderick J, Peirs S, Menten B, Loh ML, Hunger SP, Silverman LB, Harris MH, Stevenson KE, Weinstock DM, Weng AP, Van Vlierberghe P, D'Andrea AD, Gutierrez A. PLoS One. 2019 Nov 13;14(11):e0221288. doi: 10.1371/journal.pone.0221288. eCollection 2019. PubMed |
| Lung Mammary Metastases but Not Primary Tumors Induce Accumulation of Atypical Large Platelets and Their Chemokine Expression. Zheng W, Zhang H, Zhao D, Zhang J, Pollard JW. Cell Rep. 2019 Nov 12;29(7):1747-1755.e4. doi: 10.1016/j.celrep.2019.10.016. PubMed |
| DUX4-Induced Histone Variants H3.X and H3.Y Mark DUX4 Target Genes for Expression. Resnick R, Wong CJ, Hamm DC, Bennett SR, Skene PJ, Hake SB, Henikoff S, van der Maarel SM, Tapscott SJ. Cell Rep. 2019 Nov 12;29(7):1812-1820.e5. doi: 10.1016/j.celrep.2019.10.025. PubMed |
| NIX-Mediated Mitophagy Promotes Effector Memory Formation in Antigen-Specific CD8(+) T Cells. Gupta SS, Sharp R, Hofferek C, Kuai L, Dorn GW 2nd, Wang J, Chen M. Cell Rep. 2019 Nov 12;29(7):1862-1877.e7. doi: 10.1016/j.celrep.2019.10.032. PubMed |
| Sox2 and Klf4 as the Functional Core in Pluripotency Induction without Exogenous Oct4. An Z, Liu P, Zheng J, Si C, Li T, Chen Y, Ma T, Zhang MQ, Zhou Q, Ding S. Cell Rep. 2019 Nov 12;29(7):1986-2000.e8. doi: 10.1016/j.celrep.2019.10.026. PubMed |
| eIF4A supports an oncogenic translation program in pancreatic ductal adenocarcinoma. Chan K, Robert F, Oertlin C, Kapeller-Libermann D, Avizonis D, Gutierrez J, Handly-Santana A, Doubrovin M, Park J, Schoepfer C, Da Silva B, Yao M, Gorton F, Shi J, Thomas CJ, Brown LE, Porco JA Jr, Pollak M, Larsson O, Pelletier J, Chio IIC. Nat Commun. 2019 Nov 13;10(1):5151. doi: 10.1038/s41467-019-13086-5. PubMed |
| Host signaling and EGR1 transcriptional control of human cytomegalovirus replication and latency. Buehler J, Carpenter E, Zeltzer S, Igarashi S, Rak M, Mikell I, Nelson JA, Goodrum F. PLoS Pathog. 2019 Nov 14;15(11):e1008037. doi: 10.1371/journal.ppat.1008037. eCollection 2019 Nov. PubMed |
| In vitro assay for the development of small molecule inhibitors targeting PD-1/PD-L1. Zhai W, Zhou X, Du J, Gao Y. Methods Enzymol. 2019;629:361-381. doi: 10.1016/bs.mie.2019.05.051. Epub 2019 Jun 17. PubMed |
| The KDM5A/RBP2 histone demethylase represses NOTCH signaling to sustain neuroendocrine differentiation and promote small cell lung cancer tumorigenesis. Oser MG, Sabet AH, Gao W, Chakraborty AA, Schinzel AC, Jennings RB, Fonseca R, Bonal DM, Booker MA, Flaifel A, Novak JS, Christensen CL, Zhang H, Herbert ZT, Tolstorukov MY, Buss EJ, Wong KK, Bronson RT, Nguyen QD, Signoretti S, Kaelin WG Jr. Genes Dev. 2019 Dec 1;33(23-24):1718-1738. doi: 10.1101/gad.328336.119. Epub 2019 Nov 14. PubMed |
| SERPINE2 promotes esophageal squamous cell carcinoma metastasis by activating BMP4. Zhang J, Luo A, Huang F, Gong T, Liu Z. Cancer Lett. 2020 Jan 28;469:390-398. doi: 10.1016/j.canlet.2019.11.011. Epub 2019 Nov 12. PubMed |
| Hemogenic Reprogramming of Human Fibroblasts by Enforced Expression of Transcription Factors. Silverio-Alves R, Gomes AM, Kurochkin I, Moore KA, Pereira CF. J Vis Exp. 2019 Nov 4;(153). doi: 10.3791/60112. PubMed |
| Metabolic interaction of hydrogen peroxide and hypoxia in zebrafish fibroblasts. Dikova V, Vorhauser J, Geng A, Pelster B, Sandbichler AM. Free Radic Biol Med. 2019 Nov 15. pii: S0891-5849(19)31527-8. doi: 10.1016/j.freeradbiomed.2019.11.015. PubMed |
| Delivery of nitric oxide with a nanocarrier promotes tumour vessel normalization and potentiates anti-cancer therapies. Sung YC, Jin PR, Chu LA, Hsu FF, Wang MR, Chang CC, Chiou SJ, Qiu JT, Gao DY, Lin CC, Chen YS, Hsu YC, Wang J, Wang FN, Yu PL, Chiang AS, Wu AY, Ko JJ, Lai CP, Lu TT, Chen Y. Nat Nanotechnol. 2019 Dec;14(12):1160-1169. doi: 10.1038/s41565-019-0570-3. Epub 2019 Nov 18. PubMed |
| EPS8 Facilitates Uncoating of Influenza A Virus. Larson GP, Tran V, Yu S, Cai Y, Higgins CA, Smith DM, Baker SF, Radoshitzky SR, Kuhn JH, Mehle A. Cell Rep. 2019 Nov 19;29(8):2175-2183.e4. doi: 10.1016/j.celrep.2019.10.064. PubMed |
| 3D Cellular Architecture Modulates Tyrosine Kinase Activity, Thereby Switching CD95-Mediated Apoptosis to Survival. Gulculer Balta GS, Monzel C, Kleber S, Beaudouin J, Balta E, Kaindl T, Chen S, Gao L, Thiemann M, Wirtz CR, Samstag Y, Tanaka M, Martin-Villalba A. Cell Rep. 2019 Nov 19;29(8):2295-2306.e6. doi: 10.1016/j.celrep.2019.10.054. PubMed |
| Suppressing Aneuploidy-Associated Phenotypes Improves the Fitness of Trisomy 21 Cells. Hwang S, Williams JF, Kneissig M, Lioudyno M, Rivera I, Helguera P, Busciglio J, Storchova Z, King MC, Torres EM. Cell Rep. 2019 Nov 19;29(8):2473-2488.e5. doi: 10.1016/j.celrep.2019.10.059. PubMed |
| Hepatitis Delta Virus Alters the Autophagy Process To Promote Its Genome Replication. Khabir M, Aliche AZ, Sureau C, Blanchet M, Labonte P. J Virol. 2020 Jan 31;94(4). pii: JVI.01936-19. doi: 10.1128/JVI.01936-19. Print 2020 Jan 31. PubMed |
| The ribosomal P-stalk couples amino acid starvation to GCN2 activation in mammalian cells. Harding HP, Ordonez A, Allen F, Parts L, Inglis AJ, Williams RL, Ron D. Elife. 2019 Nov 21;8. pii: 50149. doi: 10.7554/eLife.50149. PubMed |
| Optogenetic control of mesenchymal cell fate towards precise bone regeneration. Wang W, Huang D, Ren J, Li R, Feng Z, Guan C, Bao B, Cai B, Ling J, Zhou C. Theranostics. 2019 Oct 18;9(26):8196-8205. doi: 10.7150/thno.36455. eCollection 2019. PubMed |
| A retention-release mechanism based on RAB11FIP2 for AMPA receptor synaptic delivery during long-term potentiation. Royo M, Gutierrez Y, Fernandez-Monreal M, Gutierrez-Eisman S, Jimenez R, Jurado S, Esteban JA. J Cell Sci. 2019 Dec 16;132(24). pii: jcs.234237. doi: 10.1242/jcs.234237. PubMed |
| Functional Enhancers Shape Extrachromosomal Oncogene Amplifications. Morton AR, Dogan-Artun N, Faber ZJ, MacLeod G, Bartels CF, Piazza MS, Allan KC, Mack SC, Wang X, Gimple RC, Wu Q, Rubin BP, Shetty S, Angers S, Dirks PB, Sallari RC, Lupien M, Rich JN, Scacheri PC. Cell. 2019 Nov 27;179(6):1330-1341.e13. doi: 10.1016/j.cell.2019.10.039. Epub 2019 Nov 21. PubMed |
| Xenotransplanted Human Cortical Neurons Reveal Species-Specific Development and Functional Integration into Mouse Visual Circuits. Linaro D, Vermaercke B, Iwata R, Ramaswamy A, Libe-Philippot B, Boubakar L, Davis BA, Wierda K, Davie K, Poovathingal S, Penttila PA, Bilheu A, De Bruyne L, Gall D, Conzelmann KK, Bonin V, Vanderhaeghen P. Neuron. 2019 Dec 4;104(5):972-986.e6. doi: 10.1016/j.neuron.2019.10.002. Epub 2019 Nov 21. PubMed |
| BNC1 regulates cell heterogeneity in human pluripotent stem cell-derived epicardium. Gambardella L, McManus SA, Moignard V, Sebukhan D, Delaune A, Andrews S, Bernard WG, Morrison MA, Riley PR, Gottgens B, Gambardella Le Novere N, Sinha S. Development. 2019 Dec 13;146(24). pii: dev.174441. doi: 10.1242/dev.174441. PubMed |
| Entry by multiple picornaviruses is dependent on a pathway that includes TNK2, WASL, and NCK1. Jiang H, Leung C, Tahan S, Wang D. Elife. 2019 Nov 26;8. pii: 50276. doi: 10.7554/eLife.50276. PubMed |
| Reciprocal and Autonomous Glucocorticoid and Androgen Receptor Activation in Salivary Duct Carcinoma. Mitani Y, Lin SH, Pytynia KB, Ferrarotto R, El-Naggar AK. Clin Cancer Res. 2019 Nov 26. pii: 1078-0432.CCR-19-1603. doi: 10.1158/1078-0432.CCR-19-1603. PubMed |
| Sustained Secretion of the Antimicrobial Peptide S100A7 Is Dependent on the Downregulation of Caspase-8. Bhatt T, Bhosale A, Bajantri B, Mathapathi MS, Rizvi A, Scita G, Majumdar A, Jamora C. Cell Rep. 2019 Nov 26;29(9):2546-2555.e4. doi: 10.1016/j.celrep.2019.10.090. PubMed |
| Global Analysis of Enhancer Targets Reveals Convergent Enhancer-Driven Regulatory Modules. Xie S, Armendariz D, Zhou P, Duan J, Hon GC. Cell Rep. 2019 Nov 26;29(9):2570-2578.e5. doi: 10.1016/j.celrep.2019.10.073. PubMed |
| The targetable kinase PIM1 drives ALK inhibitor resistance in high-risk neuroblastoma independent of MYCN status. Trigg RM, Lee LC, Prokoph N, Jahangiri L, Reynolds CP, Amos Burke GA, Probst NA, Han M, Matthews JD, Lim HK, Manners E, Martinez S, Pastor J, Blanco-Aparicio C, Merkel O, de Los Fayos Alonso IG, Kodajova P, Tangermann S, Hogler S, Luo J, Kenner L, Turner SD. Nat Commun. 2019 Nov 28;10(1):5428. doi: 10.1038/s41467-019-13315-x. PubMed |
| Evaluation of reference genes for quantitative real-time PCR in Wharton's Jelly-derived mesenchymal stem cells after lentiviral transduction and differentiation. Borkowska P, Zielinska A, Paul-Samojedny M, Stojko R, Kowalski J. Mol Biol Rep. 2020 Feb;47(2):1107-1115. doi: 10.1007/s11033-019-05207-6. Epub 2019 Nov 28. PubMed |
CRISPR-Switch regulates sgRNA activity by Cre recombination for sequential editing of two loci.
Chylinski K, Hubmann M, Hanna RE, Yanchus C, Michlits G, Uijttewaal ECH, Doench J, Schramek D, Elling U.
Nat Commun. 2019 Nov 29;10(1):5454. doi: 10.1038/s41467-019-13403-y.
PubMed
Associated Plasmids |
| KSHV activates unfolded protein response sensors but suppresses downstream transcriptional responses to support lytic replication. Johnston BP, Pringle ES, McCormick C. PLoS Pathog. 2019 Dec 2;15(12):e1008185. doi: 10.1371/journal.ppat.1008185. eCollection 2019 Dec. PubMed |
| ADAP1 promotes invasive squamous cell carcinoma progression and predicts patient survival. Van Duzer A, Taniguchi S, Elhance A, Tsujikawa T, Oshimori N. Life Sci Alliance. 2019 Dec 2;2(6). pii: 2/6/e201900582. doi: 10.26508/lsa.201900582. Print 2019 Dec. PubMed |
| A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity. Khan S, Zhang X, Lv D, Zhang Q, He Y, Zhang P, Liu X, Thummuri D, Yuan Y, Wiegand JS, Pei J, Zhang W, Sharma A, McCurdy CR, Kuruvilla VM, Baran N, Ferrando AA, Kim YM, Rogojina A, Houghton PJ, Huang G, Hromas R, Konopleva M, Zheng G, Zhou D. Nat Med. 2019 Dec;25(12):1938-1947. doi: 10.1038/s41591-019-0668-z. Epub 2019 Dec 2. PubMed |
| Mechanisms of nuclear content loading to exosomes. Yokoi A, Villar-Prados A, Oliphint PA, Zhang J, Song X, De Hoff P, Morey R, Liu J, Roszik J, Clise-Dwyer K, Burks JK, O'Halloran TJ, Laurent LC, Sood AK. Sci Adv. 2019 Nov 20;5(11):eaax8849. doi: 10.1126/sciadv.aax8849. eCollection 2019 Nov. PubMed |
| Suppression of Ribosomal Pausing by eIF5A Is Necessary to Maintain the Fidelity of Start Codon Selection. Manjunath H, Zhang H, Rehfeld F, Han J, Chang TC, Mendell JT. Cell Rep. 2019 Dec 3;29(10):3134-3146.e6. doi: 10.1016/j.celrep.2019.10.129. PubMed |
| Exploring the potential of BH3 mimetic therapy in squamous cell carcinoma of the head and neck. Carter RJ, Milani M, Butterworth M, Alotibi A, Harper N, Yedida G, Greaves G, Al-Zebeeby A, Jorgensen AL, Schache AG, Risk JM, Shaw RJ, Jones TM, Sacco JJ, Hurlstone A, Cohen GM, Varadarajan S. Cell Death Dis. 2019 Dec 4;10(12):912. doi: 10.1038/s41419-019-2150-8. PubMed |
| Reactive oxygen/nitrogen species contribute substantially to the antileukemia effect of APO866, a NAD lowering agent. Cloux AJ, Aubry D, Heulot M, Widmann C, ElMokh O, Piacente F, Cea M, Nencioni A, Bellotti A, Bouzourene K, Pellegrin M, Mazzolai L, Duchosal MA, Nahimana A. Oncotarget. 2019 Nov 19;10(62):6723-6738. doi: 10.18632/oncotarget.27336. eCollection 2019 Nov 19. PubMed |
| IL-36gamma drives skin toxicity induced by EGFR/MEK inhibition and commensal Cutibacterium acnes. Satoh TK, Mellett M, Meier-Schiesser B, Fenini G, Otsuka A, Beer HD, Rordorf T, Maul JT, Hafner J, Navarini AA, Contassot E, French LE. J Clin Invest. 2020 Feb 4. pii: 128678. doi: 10.1172/JCI128678. PubMed |
| Deregulation of the Histone Lysine-Specific Demethylase 1 Is Involved in Human Hepatocellular Carcinoma. Kim S, Bolatkan A, Kaneko S, Ikawa N, Asada K, Komatsu M, Hayami S, Ojima H, Abe N, Yamaue H, Hamamoto R. Biomolecules. 2019 Dec 1;9(12). pii: biom9120810. doi: 10.3390/biom9120810. PubMed |
| Nanoscale coupling of endocytic pit growth and stability. Lehmann M, Lukonin I, Noe F, Schmoranzer J, Clementi C, Loerke D, Haucke V. Sci Adv. 2019 Nov 27;5(11):eaax5775. doi: 10.1126/sciadv.aax5775. eCollection 2019 Nov. PubMed |
| CSB promoter downregulation via histone H3 hypoacetylation is an early determinant of replicative senescence. Crochemore C, Fernandez-Molina C, Montagne B, Salles A, Ricchetti M. Nat Commun. 2019 Dec 6;10(1):5576. doi: 10.1038/s41467-019-13314-y. PubMed |
| A generic cell surface ligand system for studying cell-cell recognition. Denham EM, Barton MI, Black SM, Bridge MJ, de Wet B, Paterson RL, van der Merwe PA, Goyette J. PLoS Biol. 2019 Dec 9;17(12):e3000549. doi: 10.1371/journal.pbio.3000549. eCollection 2019 Dec. PubMed |
| Vitamin D promotes the cisplatin sensitivity of oral squamous cell carcinoma by inhibiting LCN2-modulated NF-kappaB pathway activation through RPS3. Huang Z, Zhang Y, Li H, Zhou Y, Zhang Q, Chen R, Jin T, Hu K, Li S, Wang Y, Chen W, Huang Z. Cell Death Dis. 2019 Dec 9;10(12):936. doi: 10.1038/s41419-019-2177-x. PubMed |
| Expression of AXL receptor tyrosine kinase relates to monocyte dysfunction and severity of cirrhosis. Brenig R, Pop OT, Triantafyllou E, Geng A, Singanayagam A, Perez-Shibayama C, Besse L, Cupovic J, Kunzler P, Boldanova T, Brand S, Semela D, Duong FH, Weston CJ, Ludewig B, Heim MH, Wendon J, Antoniades CG, Bernsmeier C. Life Sci Alliance. 2019 Dec 10;3(1). pii: 3/1/e201900465. doi: 10.26508/lsa.201900465. Print 2020 Jan. PubMed |
| Nucleic acid-targeted pathogen reduction technique in red blood cells by UV-generated oxygen radicals for optimising recipient safety. Zhang Q, Wu C, Fan Y, Xu T, Meng Q, Wang S, Liu Q, Yao C, Jiang T. Transfus Med. 2019 Dec 10. doi: 10.1111/tme.12654. PubMed |
| Regulated resurfacing of a somatostatin receptor storage compartment fine-tunes pituitary secretion. Alshafie W, Francis V, Bednarz K, Pan YE, Stroh T, McPherson PS. J Cell Biol. 2020 Jan 6;219(1). pii: 132745. doi: 10.1083/jcb.201904054. PubMed |
| Endogenous IGF Signaling Directs Heterogeneous Mesoderm Differentiation in Human Embryonic Stem Cells. Yang Y, Ren Z, Xu F, Meng Y, Zhang Y, Ai N, Long Y, Fok HI, Deng C, Zhao X, Huang L, Zhao Q, Wang J, Liu W, Ge W, Chen G. Cell Rep. 2019 Dec 10;29(11):3374-3384.e5. doi: 10.1016/j.celrep.2019.11.047. PubMed |
| Post-translational Modification of OTULIN Regulates Ubiquitin Dynamics and Cell Death. Douglas T, Saleh M. Cell Rep. 2019 Dec 10;29(11):3652-3663.e5. doi: 10.1016/j.celrep.2019.11.014. PubMed |
| A primate-specific retroviral enhancer wires the XACT lncRNA into the core pluripotency network in humans. Casanova M, Moscatelli M, Chauviere LE, Huret C, Samson J, Liyakat Ali TM, Rosspopoff O, Rougeulle C. Nat Commun. 2019 Dec 11;10(1):5652. doi: 10.1038/s41467-019-13551-1. PubMed |
| NOTCH1 signaling in oral squamous cell carcinoma via a TEL2/SERPINE1 axis. Salameti V, Bhosale PG, Ames-Draycott A, Sipila K, Watt FM. Oncotarget. 2019 Nov 26;10(63):6791-6804. doi: 10.18632/oncotarget.27306. eCollection 2019 Nov 26. PubMed |
| Significant Role of Dicer and miR-223 in Adipose Tissue of Polycystic Ovary Syndrome Patients. Qin L, Chen J, Tang L, Zuo T, Chen H, Gao R, Xu W. Biomed Res Int. 2019 Nov 11;2019:9193236. doi: 10.1155/2019/9193236. eCollection 2019. PubMed |
| ARID1A prevents squamous cell carcinoma initiation and chemoresistance by antagonizing pRb/E2F1/c-Myc-mediated cancer stemness. Luo Q, Wu X, Chang W, Zhao P, Nan Y, Zhu X, Katz JP, Su D, Liu Z. Cell Death Differ. 2019 Dec 12. pii: 10.1038/s41418-019-0475-6. doi: 10.1038/s41418-019-0475-6. PubMed |
| Telophase correction refines division orientation in stratified epithelia. Lough KJ, Byrd KM, Descovich CP, Spitzer DC, Bergman AJ, Beaudoin GM 3rd, Reichardt LF, Williams SE. Elife. 2019 Dec 13;8. pii: 49249. doi: 10.7554/eLife.49249. PubMed |
| Inhibition of Osteoclastogenesis by the RNA-Binding Protein QKI5: a Novel Approach to Protect from Bone Resorption. Rauwel B, Degboe Y, Diallo K, Sayegh S, Baron M, Boyer JF, Constantin A, Cantagrel A, Davignon JL. J Bone Miner Res. 2019 Dec 13. doi: 10.1002/jbmr.3943. PubMed |
| Proteolytic Processing of Neuregulin 2. Czarnek M, Bereta J. Mol Neurobiol. 2019 Dec 14. pii: 10.1007/s12035-019-01846-9. doi: 10.1007/s12035-019-01846-9. PubMed |
| RCC2 promotes breast cancer progression through regulation of Wnt signaling and inducing EMT. Chen Z, Wu W, Huang Y, Xie L, Li Y, Chen H, Li W, Yin D, Hu K. J Cancer. 2019 Nov 1;10(27):6837-6847. doi: 10.7150/jca.36430. eCollection 2019. PubMed |
| Modulation of N-Methyl-N-nitrosourea Mutagenesis in Mouse Embryo Fibroblasts Derived from the gpt Delta Mouse by an Inhibitor of the O(6)-Methylguanine Methyltransferase, MGMT. Thongararm P, Fedeles BI, Khumsubdee S, Armijo AL, Kim L, Thiantanawat A, Promvijit J, Navasumrit P, Ruchirawat M, Croy RG, Essigmann JM. Chem Res Toxicol. 2020 Feb 17;33(2):625-633. doi: 10.1021/acs.chemrestox.9b00444. Epub 2019 Dec 24. PubMed |
| APOBEC3A is a prominent cytidine deaminase in breast cancer. Cortez LM, Brown AL, Dennis MA, Collins CD, Brown AJ, Mitchell D, Mertz TM, Roberts SA. PLoS Genet. 2019 Dec 16;15(12):e1008545. doi: 10.1371/journal.pgen.1008545. eCollection 2019 Dec. PubMed |
| Ly49R activation receptor drives self-MHC-educated NK cell immunity against cytomegalovirus infection. Gamache A, Cronk JM, Nash WT, Puchalski P, Gillespie A, Wei H, Gray L, Hammarskjold ML, Xu W, Brown MG. Proc Natl Acad Sci U S A. 2019 Dec 16. pii: 1913064117. doi: 10.1073/pnas.1913064117. PubMed |
| Inhibition of ULK1 and Beclin1 by an alpha-herpesvirus Akt-like Ser/Thr kinase limits autophagy to stimulate virus replication. Rubio RM, Mohr I. Proc Natl Acad Sci U S A. 2019 Dec 16. pii: 1915139116. doi: 10.1073/pnas.1915139116. PubMed |
| TULIP2: An Improved Method for the Identification of Ubiquitin E3-Specific Targets. Salas-Lloret D, Agabitini G, Gonzalez-Prieto R. Front Chem. 2019 Nov 26;7:802. doi: 10.3389/fchem.2019.00802. eCollection 2019. PubMed |
| Cellular IP6 Levels Limit HIV Production while Viruses that Cannot Efficiently Package IP6 Are Attenuated for Infection and Replication. Mallery DL, Faysal KMR, Kleinpeter A, Wilson MSC, Vaysburd M, Fletcher AJ, Novikova M, Bocking T, Freed EO, Saiardi A, James LC. Cell Rep. 2019 Dec 17;29(12):3983-3996.e4. doi: 10.1016/j.celrep.2019.11.050. PubMed |
| LC3C-Mediated Autophagy Selectively Regulates the Met RTK and HGF-Stimulated Migration and Invasion. Bell ES, Coelho PP, Ratcliffe CDH, Rajadurai CV, Peschard P, Vaillancourt R, Zuo D, Park M. Cell Rep. 2019 Dec 17;29(12):4053-4068.e6. doi: 10.1016/j.celrep.2019.11.063. PubMed |
| Spatial Genome Re-organization between Fetal and Adult Hematopoietic Stem Cells. Chen C, Yu W, Tober J, Gao P, He B, Lee K, Trieu T, Blobel GA, Speck NA, Tan K. Cell Rep. 2019 Dec 17;29(12):4200-4211.e7. doi: 10.1016/j.celrep.2019.11.065. PubMed |
| The phytohormone forchlorfenuron decreases viability and proliferation of malignant mesothelioma cells in vitro and in vivo. Blum W, Henzi T, Pecze L, Diep KL, Bochet CG, Schwaller B. Oncotarget. 2019 Dec 10;10(65):6944-6956. doi: 10.18632/oncotarget.27341. eCollection 2019 Dec 10. PubMed |
Molecular Tuning of the Axonal Mitochondrial Ca(2+) Uniporter Ensures Metabolic Flexibility of Neurotransmission.
Ashrafi G, de Juan-Sanz J, Farrell RJ, Ryan TA.
Neuron. 2019 Dec 10. pii: S0896-6273(19)30984-5. doi: 10.1016/j.neuron.2019.11.020.
PubMed
Associated Plasmids |
| The SINEB1 element in the long non-coding RNA Malat1 is necessary for TDP-43 proteostasis. Nguyen TM, Kabotyanski EB, Reineke LC, Shao J, Xiong F, Lee JH, Dubrulle J, Johnson H, Stossi F, Tsoi PS, Choi KJ, Ellis AG, Zhao N, Cao J, Adewunmi O, Ferreon JC, Ferreon ACM, Neilson JR, Mancini MA, Chen X, Kim J, Ma L, Li W, Rosen JM. Nucleic Acids Res. 2020 Mar 18;48(5):2621-2642. doi: 10.1093/nar/gkz1176. PubMed |
| Low-Level Saturated Fatty Acid Palmitate Benefits Liver Cells by Boosting Mitochondrial Metabolism via CDK1-SIRT3-CPT2 Cascade. Liu L, Xie B, Fan M, Candas-Green D, Jiang JX, Wei R, Wang Y, Chen HW, Hu Y, Li JJ. Dev Cell. 2020 Jan 27;52(2):196-209.e9. doi: 10.1016/j.devcel.2019.11.012. Epub 2019 Dec 19. PubMed |
| The stem cell-specific long noncoding RNA HOXA10-AS in the pathogenesis of KMT2A-rearranged leukemia. Al-Kershi S, Bhayadia R, Ng M, Verboon L, Emmrich S, Gack L, Schwarzer A, Strowig T, Heckl D, Klusmann JH. Blood Adv. 2019 Dec 23;3(24):4252-4263. doi: 10.1182/bloodadvances.2019032029. PubMed |
| CRISPR-mediated modeling and functional validation of candidate tumor suppressor genes in small cell lung cancer. Ng SR, Rideout WM 3rd, Akama-Garren EH, Bhutkar A, Mercer KL, Schenkel JM, Bronson RT, Jacks T. Proc Natl Acad Sci U S A. 2020 Jan 7;117(1):513-521. doi: 10.1073/pnas.1821893117. Epub 2019 Dec 23. PubMed |
Subcellular drug targeting illuminates local kinase action.
Bucko PJ, Lombard CK, Rathbun L, Garcia I, Bhat A, Wordeman L, Smith FD, Maly DJ, Hehnly H, Scott JD.
Elife. 2019 Dec 24;8. pii: 52220. doi: 10.7554/eLife.52220.
PubMed
Associated Plasmids |
| Sideroflexin 4 affects Fe-S cluster biogenesis, iron metabolism, mitochondrial respiration and heme biosynthetic enzymes. Paul BT, Tesfay L, Winkler CR, Torti FM, Torti SV. Sci Rep. 2019 Dec 23;9(1):19634. doi: 10.1038/s41598-019-55907-z. PubMed |
| WBP11 is required for splicing the TUBGCP6 pre-mRNA to promote centriole duplication. Park EM, Scott PM, Clutario K, Cassidy KB, Zhan K, Gerber SA, Holland AJ. J Cell Biol. 2020 Jan 6;219(1). pii: 133543. doi: 10.1083/jcb.201904203. PubMed |
| Construction of an Inducible CRISPR/Cas9 System for CXCR4 Gene and Demonstration of its Effects on MKN-45 Cells. Peng Y, Yang T, Tang X, Chen F, Wang S. Cell Biochem Biophys. 2019 Dec 24. pii: 10.1007/s12013-019-00898-x. doi: 10.1007/s12013-019-00898-x. PubMed |
| Molecular Basis for Autosomal-Dominant Renal Fanconi Syndrome Caused by HNF4A. Marchesin V, Perez-Marti A, Le Meur G, Pichler R, Grand K, Klootwijk ED, Kesselheim A, Kleta R, Lienkamp S, Simons M. Cell Rep. 2019 Dec 24;29(13):4407-4421.e5. doi: 10.1016/j.celrep.2019.11.066. PubMed |
| Silencing of Long Non-coding RNA RP1-93H18.6 Acts as a Tumor Suppressor in Cervical Cancer through the Blockade of the PI3K/Akt Axis. Wang Q, Yan SP, Chu DX, Xie Y, Wang CF, Zhang JY, Li WC, Guo RX. Mol Ther Nucleic Acids. 2019 Nov 15;19:304-317. doi: 10.1016/j.omtn.2019.10.041. PubMed |
| Enterovirus 71 Represses Interleukin Enhancer-Binding Factor 2 Production and Nucleus Translocation to Antagonize ILF2 Antiviral Effects. Jin J, Wang W, Ai S, Liu W, Song Y, Luo Z, Zhang Q, Wu K, Liu Y, Wu J. Viruses. 2019 Dec 23;12(1). pii: v12010022. doi: 10.3390/v12010022. PubMed |
| Functional Dissection of Mitosis Using Immortalized Fibroblasts from the Indian Muntjac, a Placental Mammal with Only Three Chromosomes. Almeida AC, Drpic D, Okada N, Bravo J, Madureira M, Maiato H. Methods Mol Biol. 2020;2101:247-266. doi: 10.1007/978-1-0716-0219-5_16. PubMed |
| Signalling lymphocyte activation molecule family member 9 is found on select subsets of antigen-presenting cells and promotes resistance to Salmonella infection. Wilson TJ, Clare S, Mikulin J, Johnson CM, Harcourt K, Lyons PA, Dougan G, Smith KGC. Immunology. 2020 Apr;159(4):393-403. doi: 10.1111/imm.13169. Epub 2020 Jan 28. PubMed |
| Injectable, scalable 3D tissue-engineered model of marrow hematopoiesis. Tavakol DN, Tratwal J, Bonini F, Genta M, Campos V, Burch P, Hoehnel S, Beduer A, Alessandrini M, Naveiras O, Braschler T. Biomaterials. 2020 Feb;232:119665. doi: 10.1016/j.biomaterials.2019.119665. Epub 2019 Dec 11. PubMed |
| Oncogenic K-ras Induces Mitochondrial OPA3 Expression to Promote Energy Metabolism in Pancreatic Cancer Cells. Meng N, Glorieux C, Zhang Y, Liang L, Zeng P, Lu W, Huang P. Cancers (Basel). 2019 Dec 25;12(1). pii: cancers12010065. doi: 10.3390/cancers12010065. PubMed |
| Efficient Modulation of TP53 Expression in Human Induced Pluripotent Stem Cells. Uhlmann C, Kuhn LM, Tigges J, Fritsche E, Kahlert UD. Curr Protoc Stem Cell Biol. 2020 Mar;52(1):e102. doi: 10.1002/cpsc.102. PubMed |
| CDK7 Inhibition Potentiates Genome Instability Triggering Anti-tumor Immunity in Small Cell Lung Cancer. Zhang H, Christensen CL, Dries R, Oser MG, Deng J, Diskin B, Li F, Pan Y, Zhang X, Yin Y, Papadopoulos E, Pyon V, Thakurdin C, Kwiatkowski N, Jani K, Rabin AR, Castro DM, Chen T, Silver H, Huang Q, Bulatovic M, Dowling CM, Sundberg B, Leggett A, Ranieri M, Han H, Li S, Yang A, Labbe KE, Almonte C, Sviderskiy VO, Quinn M, Donaghue J, Wang ES, Zhang T, He Z, Velcheti V, Hammerman PS, Freeman GJ, Bonneau R, Kaelin WG Jr, Sutherland KD, Kersbergen A, Aguirre AJ, Yuan GC, Rothenberg E, Miller G, Gray NS, Wong KK. Cancer Cell. 2020 Jan 13;37(1):37-54.e9. doi: 10.1016/j.ccell.2019.11.003. Epub 2019 Dec 26. PubMed |
| Fumarate and oxidative stress synergize to promote stability of C/EBP homologous protein in the adipocyte. Manuel AM, Walla MD, Dorn MT, Tanis RM, Piroli GG, Frizzell N. Free Radic Biol Med. 2020 Feb 20;148:70-82. doi: 10.1016/j.freeradbiomed.2019.12.037. Epub 2019 Dec 26. PubMed |
| Sonogenetic Modulation of Cellular Activities Using an Engineered Auditory-Sensing Protein. Huang YS, Fan CH, Hsu N, Chiu NH, Wu CY, Chang CY, Wu BH, Hong SR, Chang YC, Yan-Tang Wu A, Guo V, Chiang YC, Hsu WC, Chen L, Pin-Kuang Lai C, Yeh CK, Lin YC. Nano Lett. 2020 Feb 12;20(2):1089-1100. doi: 10.1021/acs.nanolett.9b04373. Epub 2020 Jan 2. PubMed |
| A solid-phase transfection platform for arrayed CRISPR screens. Sercin O, Reither S, Roidos P, Ballin N, Palikyras S, Baginska A, Rein K, Llamazares M, Halavatyi A, Winter H, Muley T, Jurkowska RZ, Abdollahi A, Zenke FT, Neumann B, Mardin BR. Mol Syst Biol. 2019 Dec;15(12):e8983. doi: 10.15252/msb.20198983. PubMed |
| Genes Involved in the Transcriptional Regulation of Pluripotency Are Expressed in Malignant Tumors of the Uterine Cervix and Can Induce Tumorigenic Capacity in a Nontumorigenic Cell Line. Ruiz G, Valencia-Gonzalez HA, Perez-Montiel D, Munoz F, Ocadiz-Delgado R, Fernandez-Retana J, Perez-Plasencia C, Resendis-Antonio O, Gariglio P, Garcia-Carranca A. Stem Cells Int. 2019 Dec 1;2019:7683817. doi: 10.1155/2019/7683817. eCollection 2019. PubMed |
| Deuterium Tracing to Interrogate Compartment-Specific NAD(P)H Metabolism in Cultured Mammalian Cells. Lim EW, Parker SJ, Metallo CM. Methods Mol Biol. 2020;2088:51-71. doi: 10.1007/978-1-0716-0159-4_4. PubMed |
| Frizzled 1 and Wnt1 as new potential therapeutic targets in the traumatically injured spinal cord. Gonzalez P, Gonzalez-Fernandez C, Campos-Martin Y, Mollejo M, Carballosa-Gautam M, Marcillo A, Norenberg M, Rodriguez FJ. Cell Mol Life Sci. 2020 Jan 3. pii: 10.1007/s00018-019-03427-4. doi: 10.1007/s00018-019-03427-4. PubMed |
| Epigenetic priming by Dot1l in lymphatic endothelial progenitors ensures normal lymphatic development and function. Yoo H, Lee YJ, Park C, Son D, Choi DY, Park JH, Choi HJ, La HW, Choi YJ, Moon EH, Saur D, Chung HM, Song H, Do JT, Jang H, Lee DR, Park C, Lee OH, Cho SG, Hong SH, Kong G, Kim JH, Choi Y, Hong K. Cell Death Dis. 2020 Jan 6;11(1):14. doi: 10.1038/s41419-019-2201-1. PubMed |
| Respiratory supercomplexes act as a platform for complex III-mediated maturation of human mitochondrial complexes I and IV. Protasoni M, Perez-Perez R, Lobo-Jarne T, Harbour ME, Ding S, Penas A, Diaz F, Moraes CT, Fearnley IM, Zeviani M, Ugalde C, Fernandez-Vizarra E. EMBO J. 2020 Feb 3;39(3):e102817. doi: 10.15252/embj.2019102817. Epub 2020 Jan 8. PubMed |
| YAP regulates cell size and growth dynamics via non-cell autonomous mediators. Mugahid D, Kalocsay M, Liu X, Gruver JS, Peshkin L, Kirschner MW. Elife. 2020 Jan 9;9. pii: 53404. doi: 10.7554/eLife.53404. PubMed |
| Outside-in regulation of the readily releasable pool of synaptic vesicles by alpha2delta-1. Martinez San Segundo P, Terni B, Burgueno J, Monroy X, Dordal A, Merlos M, Llobet A. FASEB J. 2020 Jan;34(1):1362-1377. doi: 10.1096/fj.201901551R. Epub 2019 Nov 30. PubMed |
| CRISPR-Cas9-induced IGF1 gene activation as a tool for enhancing muscle differentiation via multiple isoform expression. Roberston MJ, Raghunathan S, Potaman VN, Zhang F, Stewart MD, McConnell BK, Schwartz RJ. FASEB J. 2020 Jan;34(1):555-570. doi: 10.1096/fj.201901107RR. Epub 2019 Nov 25. PubMed |
| Species-specific consequences of an E40K missense mutation in superoxide dismutase 1 (SOD1). Draper ACE, Wilson Z, Maile C, Faccenda D, Campanella M, Piercy RJ. FASEB J. 2020 Jan;34(1):458-473. doi: 10.1096/fj.201901455R. Epub 2019 Nov 25. PubMed |
| Transcription factor NRF2 uses the Hippo pathway effector TAZ to induce tumorigenesis in glioblastomas. Escoll M, Lastra D, Pajares M, Robledinos-Anton N, Rojo AI, Fernandez-Gines R, Mendiola M, Martinez-Marin V, Esteban I, Lopez-Larrubia P, Gargini R, Cuadrado A. Redox Biol. 2020 Feb;30:101425. doi: 10.1016/j.redox.2019.101425. Epub 2020 Jan 2. PubMed |
A fluorescence activatable reporter of flavivirus NS2B-NS3 protease activity enables live imaging of infection in single cells and viral plaques.
Arias-Arias JL, MacPherson DJ, Hill ME, Hardy JA, Mora-Rodriguez R.
J Biol Chem. 2020 Jan 9. pii: RA119.011319. doi: 10.1074/jbc.RA119.011319.
PubMed
Associated Plasmids |
| Efficient and Robust NK-Cell Transduction With Baboon Envelope Pseudotyped Lentivector. Colamartino ABL, Lemieux W, Bifsha P, Nicoletti S, Chakravarti N, Sanz J, Romero H, Selleri S, Beland K, Guiot M, Tremblay-Laganiere C, Dicaire R, Barreiro L, Lee DA, Verhoeyen E, Haddad E. Front Immunol. 2019 Dec 16;10:2873. doi: 10.3389/fimmu.2019.02873. eCollection 2019. PubMed |
| Artificial escape from XCI by DNA methylation editing of the CDKL5 gene. Halmai JANM, Deng P, Gonzalez CE, Coggins NB, Cameron D, Carter JL, Buchanan FKB, Waldo JJ, Lock SR, Anderson JD, O'Geen H, Segal DJ, Nolta J, Fink KD. Nucleic Acids Res. 2020 Mar 18;48(5):2372-2387. doi: 10.1093/nar/gkz1214. PubMed |
| On-chip 3D neuromuscular model for drug screening and precision medicine in neuromuscular disease. Osaki T, Uzel SGM, Kamm RD. Nat Protoc. 2020 Feb;15(2):421-449. doi: 10.1038/s41596-019-0248-1. Epub 2020 Jan 13. PubMed |
| CRISPR/Cas9-Based Genetic Screening to Study T-Cell Function. Shang W, Wang F, Zhu Q, Wang L, Wang H. Methods Mol Biol. 2020;2111:59-70. doi: 10.1007/978-1-0716-0266-9_5. PubMed |
| Increased expression of O-GlcNAc transferase (OGT) is a biomarker for poor prognosis and allows tumorigenesis and invasion in colon cancer. Xu D, Wang W, Bian T, Yang W, Shao M, Yang H. Int J Clin Exp Pathol. 2019 Apr 1;12(4):1305-1314. eCollection 2019. PubMed |
| Epidermal autonomous VEGFA/Flt1/Nrp1 functions mediate psoriasis-like disease. Benhadou F, Glitzner E, Brisebarre A, Swedlund B, Song Y, Dubois C, Rozzi M, Paulissen C, Del Marmol V, Sibilia M, Blanpain C. Sci Adv. 2020 Jan 8;6(2):eaax5849. doi: 10.1126/sciadv.aax5849. eCollection 2020 Jan. PubMed |
| Inhibition of PP2A with LB-100 Enhances Efficacy of CAR-T Cell Therapy Against Glioblastoma. Cui J, Wang H, Medina R, Zhang Q, Xu C, Indig IH, Zhou J, Song Q, Dmitriev P, Sun MY, Guo L, Wang Y, Rosenblum JS, Kovach JS, Gilbert MR, Zhuang Z. Cancers (Basel). 2020 Jan 6;12(1). pii: cancers12010139. doi: 10.3390/cancers12010139. PubMed |
| Oxygen-dependent asparagine hydroxylation of the ubiquitin-associated (UBA) domain in Cezanne regulates ubiquitin binding. Mader J, Huber J, Bonn F, Dotsch V, Rogov VV, Bremm A. J Biol Chem. 2020 Feb 21;295(8):2160-2174. doi: 10.1074/jbc.RA119.010315. Epub 2020 Jan 14. PubMed |
| Effects of Benzophenone-3 and Propylparaben on Estrogen Receptor-Dependent R-Loops and DNA Damage in Breast Epithelial Cells and Mice. Majhi PD, Sharma A, Roberts AL, Daniele E, Majewski AR, Chuong LM, Black AL, Vandenberg LN, Schneider SS, Dunphy KA, Jerry DJ. Environ Health Perspect. 2020 Jan;128(1):17002. doi: 10.1289/EHP5221. Epub 2020 Jan 15. PubMed |
| The vitamin D receptor regulates mitochondrial function in C2C12 myoblasts. Ashcroft SP, Bass JJ, Kazi AA, Atherton PJ, Philp A. Am J Physiol Cell Physiol. 2020 Mar 1;318(3):C536-C541. doi: 10.1152/ajpcell.00568.2019. Epub 2020 Jan 15. PubMed |
| The EGFR-TMEM167A-p53 Axis Defines the Aggressiveness of Gliomas. Segura-Collar B, Gargini R, Tovar-Ambel E, Hernandez-SanMiguel E, Epifano C, Perez de Castro I, Hernandez-Lain A, Casas-Tinto S, Sanchez-Gomez P. Cancers (Basel). 2020 Jan 14;12(1). pii: cancers12010208. doi: 10.3390/cancers12010208. PubMed |
| The Relative Permittivity Changes of EGF by 50 Hz MF Exposure Neither Affect the Interaction of EGF With EGFR Nor Its Biological Effects. Fei Y, Jin Y, Zhao X, Wang Y, Qian J, Su L, Chen G. Bioelectromagnetics. 2020 Apr;41(3):241-246. doi: 10.1002/bem.22249. Epub 2020 Jan 17. PubMed |
| High-Throughput Screening Identifies Two Novel Small Molecule Enhancers of Recombinant Protein Expression. Chang J, Chen X, Wang R, Shi R, Wang X, Lu W, Ma S, Xia Q. Molecules. 2020 Jan 15;25(2). pii: molecules25020353. doi: 10.3390/molecules25020353. PubMed |
| An ultra-stable cytoplasmic antibody engineered for in vivo applications. Kabayama H, Takeuchi M, Tokushige N, Muramatsu SI, Kabayama M, Fukuda M, Yamada Y, Mikoshiba K. Nat Commun. 2020 Jan 17;11(1):336. doi: 10.1038/s41467-019-13654-9. PubMed |
| Genome-wide CRISPR-Cas9 screening reveals ubiquitous T cell cancer targeting via the monomorphic MHC class I-related protein MR1. Crowther MD, Dolton G, Legut M, Caillaud ME, Lloyd A, Attaf M, Galloway SAE, Rius C, Farrell CP, Szomolay B, Ager A, Parker AL, Fuller A, Donia M, McCluskey J, Rossjohn J, Svane IM, Phillips JD, Sewell AK. Nat Immunol. 2020 Feb;21(2):178-185. doi: 10.1038/s41590-019-0578-8. Epub 2020 Jan 20. PubMed |
| Reprogramming Fibroblasts to Neural Stem Cells by Overexpression of the Transcription Factor Ptf1a. Jin K, Zou M, Xiao D, Xiang M. Methods Mol Biol. 2020;2117:245-263. doi: 10.1007/978-1-0716-0301-7_15. PubMed |
| Rare and private spliceosomal gene mutations drive partial, complete, and dual phenocopies of hotspot alterations. Pangallo J, Kiladjian JJ, Cassinat B, Renneville A, Taylor J, Polaski JT, North K, Abdel-Wahab O, Bradley RK. Blood. 2020 Mar 26;135(13):1032-1043. doi: 10.1182/blood.2019002894. PubMed |
| Investigating Chaperonin-Containing TCP-1 subunit 2 as an essential component of the chaperonin complex for tumorigenesis. Showalter AE, Martini AC, Nierenberg D, Hosang K, Fahmi NA, Gopalan P, Khaled AS, Zhang W, Khaled AR. Sci Rep. 2020 Jan 21;10(1):798. doi: 10.1038/s41598-020-57602-w. PubMed |
| Silencing of SENP2 in Multiple Myeloma Induces Bortezomib Resistance by Activating NF-kappaB Through the Modulation of IkappaBalpha Sumoylation. Xie H, Gu Y, Wang W, Wang X, Ye X, Xin C, Lu M, Reddy BA, Shu P. Sci Rep. 2020 Jan 21;10(1):766. doi: 10.1038/s41598-020-57698-0. PubMed |
| Lentiviral Vector Production Titer Is Not Limited in HEK293T by Induced Intracellular Innate Immunity. Ferreira CB, Sumner RP, Rodriguez-Plata MT, Rasaiyaah J, Milne RS, Thrasher AJ, Qasim W, Towers GJ. Mol Ther Methods Clin Dev. 2019 Dec 24;17:209-219. doi: 10.1016/j.omtm.2019.11.021. eCollection 2020 Jun 12. PubMed |
| CXCL12-induced rescue of cortical dendritic spines and cognitive flexibility. Festa LK, Irollo E, Platt BJ, Tian Y, Floresco S, Meucci O. Elife. 2020 Jan 23;9. pii: 49717. doi: 10.7554/eLife.49717. PubMed |
| A role for ceramide glycosylation in resistance to oxaliplatin in colorectal cancer. Madigan JP, Robey RW, Poprawski JE, Huang H, Clarke CJ, Gottesman MM, Cabot MC, Rosenberg DW. Exp Cell Res. 2020 Mar 15;388(2):111860. doi: 10.1016/j.yexcr.2020.111860. Epub 2020 Jan 20. PubMed |
| Noncoding mutations target cis-regulatory elements of the FOXA1 plexus in prostate cancer. Zhou S, Hawley JR, Soares F, Grillo G, Teng M, Madani Tonekaboni SA, Hua JT, Kron KJ, Mazrooei P, Ahmed M, Arlidge C, Yun HY, Livingstone J, Huang V, Yamaguchi TN, Espiritu SMG, Zhu Y, Severson TM, Murison A, Cameron S, Zwart W, van der Kwast T, Pugh TJ, Fraser M, Boutros PC, Bristow RG, He HH, Lupien M. Nat Commun. 2020 Jan 23;11(1):441. doi: 10.1038/s41467-020-14318-9. PubMed |
| Restoring Wnt6 signaling ameliorates behavioral deficits in MeCP2 T158A mouse model of Rett syndrome. Hsu WL, Ma YL, Liu YC, Tai DJC, Lee EHY. Sci Rep. 2020 Jan 23;10(1):1074. doi: 10.1038/s41598-020-57745-w. PubMed |
| A CRISPR/Cas9 genome editing pipeline in the EndoC-betaH1 cell line to study genes implicated in beta cell function. Grotz AK, Abaitua F, Navarro-Guerrero E, Hastoy B, Ebner D, Gloyn AL. Wellcome Open Res. 2020 Apr 29;4:150. doi: 10.12688/wellcomeopenres.15447.2. eCollection 2019. PubMed |
| scMAGeCK links genotypes with multiple phenotypes in single-cell CRISPR screens. Yang L, Zhu Y, Yu H, Cheng X, Chen S, Chu Y, Huang H, Zhang J, Li W. Genome Biol. 2020 Jan 24;21(1):19. doi: 10.1186/s13059-020-1928-4. PubMed |
IL-4 controls activated neutrophil FcgammaR2b expression and migration into inflamed joints.
Panda SK, Wigerblad G, Jiang L, Jimenez-Andrade Y, Iyer VS, Shen Y, Boddul SV, Guerreiro-Cacais AO, Raposo B, Kasza Z, Wermeling F.
Proc Natl Acad Sci U S A. 2020 Jan 24. pii: 1914186117. doi: 10.1073/pnas.1914186117.
PubMed
Associated Plasmids |
ATP13A2 deficiency disrupts lysosomal polyamine export.
van Veen S, Martin S, Van den Haute C, Benoy V, Lyons J, Vanhoutte R, Kahler JP, Decuypere JP, Gelders G, Lambie E, Zielich J, Swinnen JV, Annaert W, Agostinis P, Ghesquiere B, Verhelst S, Baekelandt V, Eggermont J, Vangheluwe P.
Nature. 2020 Feb;578(7795):419-424. doi: 10.1038/s41586-020-1968-7. Epub 2020 Jan 29.
PubMed
Associated Plasmids |
| WDR5 is a conserved regulator of protein synthesis gene expression. Bryan AF, Wang J, Howard GC, Guarnaccia AD, Woodley CM, Aho ER, Rellinger EJ, Matlock BK, Flaherty DK, Lorey SL, Chung DH, Fesik SW, Liu Q, Weissmiller AM, Tansey WP. Nucleic Acids Res. 2020 Apr 6;48(6):2924-2941. doi: 10.1093/nar/gkaa051. PubMed |
| The m6A reader YTHDF1 promotes ovarian cancer progression via augmenting EIF3C translation. Liu T, Wei Q, Jin J, Luo Q, Liu Y, Yang Y, Cheng C, Li L, Pi J, Si Y, Xiao H, Li L, Rao S, Wang F, Yu J, Yu J, Zou D, Yi P. Nucleic Acids Res. 2020 Apr 17;48(7):3816-3831. doi: 10.1093/nar/gkaa048. PubMed |
| Protein tyrosine phosphatase 4A3 (PTP4A3/PRL-3) drives migration and progression of T-cell acute lymphoblastic leukemia in vitro and in vivo. Wei M, Haney MG, Rivas DR, Blackburn JS. Oncogenesis. 2020 Jan 30;9(1):6. doi: 10.1038/s41389-020-0192-5. PubMed |
| Tumor heterogeneity and clonal cooperation influence the immune selection of IFN-gamma-signaling mutant cancer cells. Williams JB, Li S, Higgs EF, Cabanov A, Wang X, Huang H, Gajewski TF. Nat Commun. 2020 Jan 30;11(1):602. doi: 10.1038/s41467-020-14290-4. PubMed |
| KANSL2 and MBNL3 are regulators of pancreatic ductal adenocarcinoma invasion. Oladimeji PO, Bakke J, Wright WC, Chen T. Sci Rep. 2020 Jan 30;10(1):1485. doi: 10.1038/s41598-020-58448-y. PubMed |
| Serine phosphorylation of the small phosphoprotein ICAP1 inhibits its nuclear accumulation. Su VL, Simon B, Draheim KM, Calderwood DA. J Biol Chem. 2020 Mar 6;295(10):3269-3284. doi: 10.1074/jbc.RA119.009794. Epub 2020 Jan 31. PubMed |
| Loss of hnRNPA2B1 inhibits malignant capability and promotes apoptosis via down-regulating Lin28B expression in ovarian cancer. Yang Y, Wei Q, Tang Y, Yuanyuan Wang, Luo Q, Zhao H, He M, Wang H, Zeng Q, Lu W, Xu J, Liu T, Yi P. Cancer Lett. 2020 Apr 10;475:43-52. doi: 10.1016/j.canlet.2020.01.029. Epub 2020 Jan 29. PubMed |
| Inhibition of the deubiquitinase USP10 induces degradation of SYK. Yang J, Meng C, Weisberg E, Case A, Lamberto I, Magin RS, Adamia S, Wang J, Gray N, Liu S, Stone R, Sattler M, Buhrlage S, Griffin JD. Br J Cancer. 2020 Apr;122(8):1175-1184. doi: 10.1038/s41416-020-0731-z. Epub 2020 Feb 4. PubMed |
| Modulation of sulfur assimilation metabolic toxicity overcomes anemia and hemochromatosis in mice. Hale AT, Brown RE, Luka Z, Hudson BH, Matta P, Williams CS, York JD. Adv Biol Regul. 2020 May;76:100694. doi: 10.1016/j.jbior.2020.100694. Epub 2020 Jan 26. PubMed |
| CRISPR/Cas9 increases mitotic gene conversion in human cells. Javidi-Parsijani P, Lyu P, Makani V, Sarhan WM, Yoo KW, El-Korashi L, Atala A, Lu B. Gene Ther. 2020 Jun;27(6):281-296. doi: 10.1038/s41434-020-0126-z. Epub 2020 Feb 4. PubMed |
| MTR4 drives liver tumorigenesis by promoting cancer metabolic switch through alternative splicing. Yu L, Kim J, Jiang L, Feng B, Ying Y, Ji KY, Tang Q, Chen W, Mai T, Dou W, Zhou J, Xiang LY, He YF, Yang D, Li Q, Fu X, Xu Y. Nat Commun. 2020 Feb 5;11(1):708. doi: 10.1038/s41467-020-14437-3. PubMed |
| Tissue-specific promoter-based reporter system for monitoring cell differentiation from iPSCs to cardiomyocytes. Fiedorowicz K, Rozwadowska N, Zimna A, Malcher A, Tutak K, Szczerbal I, Nowicka-Bauer K, Nowaczyk M, Kolanowski TJ, Labedz W, Kubaszewski L, Kurpisz M. Sci Rep. 2020 Feb 5;10(1):1895. doi: 10.1038/s41598-020-58050-2. PubMed |
| A novel NanoBiT-based assay monitors the interaction between lipoprotein lipase and GPIHBP1 in real time. Shetty SK, Walzem RL, Davies BSJ. J Lipid Res. 2020 Apr;61(4):546-559. doi: 10.1194/jlr.D119000388. Epub 2020 Feb 6. PubMed |
| Synergistic lethality between PARP-trapping and alantolactone-induced oxidative DNA damage in homologous recombination-proficient cancer cells. Wang H, Zhang S, Song L, Qu M, Zou Z. Oncogene. 2020 Apr;39(14):2905-2920. doi: 10.1038/s41388-020-1191-x. Epub 2020 Feb 6. PubMed |
| Roscovitine enhances All-trans retinoic acid (ATRA)-induced leukemia cell differentiation: Novel effects on signaling molecules for a putative Cdk2 inhibitor. Rashid A, Duan X, Gao F, Yang M, Yen A. Cell Signal. 2020 Jul;71:109555. doi: 10.1016/j.cellsig.2020.109555. Epub 2020 Feb 4. PubMed |
| Successfully transfected primary peripherally mobilized human CD34+ hematopoietic stem and progenitor cells (HSPCs) demonstrate increased susceptibility to retroviral infection. Sebrow J, Goff SP, Griffin DO. Virol J. 2020 Feb 10;17(1):22. doi: 10.1186/s12985-020-1297-3. PubMed |
| BRCA1 and S phase DNA repair pathways restrict LINE-1 retrotransposition in human cells. Mita P, Sun X, Fenyo D, Kahler DJ, Li D, Agmon N, Wudzinska A, Keegan S, Bader JS, Yun C, Boeke JD. Nat Struct Mol Biol. 2020 Feb;27(2):179-191. doi: 10.1038/s41594-020-0374-z. Epub 2020 Feb 10. PubMed |
| Blunted Vagal Cocaine- and Amphetamine-Regulated Transcript Promotes Hyperphagia and Weight Gain. Lee SJ, Krieger JP, Vergara M, Quinn D, McDougle M, de Araujo A, Darling R, Zollinger B, Anderson S, Pan A, Simonnet EJ, Pignalosa A, Arnold M, Singh A, Langhans W, Raybould HE, de Lartigue G. Cell Rep. 2020 Feb 11;30(6):2028-2039.e4. doi: 10.1016/j.celrep.2020.01.045. PubMed |
| Inhibition of USP9X Downregulates JAK2-V617F and Induces Apoptosis Synergistically with BH3 Mimetics Preferentially in Ruxolitinib-Persistent JAK2-V617F-Positive Leukemic Cells. Akiyama H, Umezawa Y, Watanabe D, Okada K, Ishida S, Nogami A, Miura O. Cancers (Basel). 2020 Feb 10;12(2). pii: cancers12020406. doi: 10.3390/cancers12020406. PubMed |
Mechanical regulation of glycolysis via cytoskeleton architecture.
Park JS, Burckhardt CJ, Lazcano R, Solis LM, Isogai T, Li L, Chen CS, Gao B, Minna JD, Bachoo R, DeBerardinis RJ, Danuser G.
Nature. 2020 Feb 12. pii: 10.1038/s41586-020-1998-1. doi: 10.1038/s41586-020-1998-1.
PubMed
Associated Plasmids |
| Cell-Penetrating Nanoparticles Activate the Inflammasome to Enhance Antibody Production by Targeting Microtubule-Associated Protein 1-Light Chain 3 for Degradation. Zhu M, Du L, Zhao R, Wang HY, Zhao Y, Nie G, Wang RF. ACS Nano. 2020 Mar 24;14(3):3703-3717. doi: 10.1021/acsnano.0c00962. Epub 2020 Feb 20. PubMed |
| Interleukin-10 delivered by mesenchymal stem cells attenuates experimental autoimmune myocarditis. Shao M, Wang D, Zhou Y, Du K, Liu W. Int Immunopharmacol. 2020 Apr;81:106212. doi: 10.1016/j.intimp.2020.106212. Epub 2020 Feb 13. PubMed |
| In Vivo Augmentation of Gut-Homing Regulatory T Cell Induction. Bi H, Wasnik S, Baylink DJ, Liu C, Tang X. J Vis Exp. 2020 Jan 22;(155). doi: 10.3791/60585. PubMed |
| Culture, Manipulation, and Orthotopic Transplantation of Mouse Bladder Tumor Organoids. Kim Y, Lee J, Kim S, Shin K. J Vis Exp. 2020 Jan 31;(155). doi: 10.3791/60469. PubMed |
| Endogenous Retrovirus Activation as a Key Mechanism of Anti-Tumor Immune Response in Radiotherapy. Lee AK, Pan D, Bao X, Hu M, Li F, Li CY. Radiat Res. 2020 Apr;193(4):305-317. doi: 10.1667/RADE-20-00013. Epub 2020 Feb 19. PubMed |
| AMPK activation does not enhance autophagy in neurons in contrast to MTORC1 inhibition: different impact on beta-amyloid clearance. Benito-Cuesta I, Ordonez-Gutierrez L, Wandosell F. Autophagy. 2021 Mar;17(3):656-671. doi: 10.1080/15548627.2020.1728095. Epub 2020 Feb 20. PubMed |
| Lineage reprogramming of fibroblasts into induced cardiac progenitor cells by CRISPR/Cas9-based transcriptional activators. Wang J, Jiang X, Zhao L, Zuo S, Chen X, Zhang L, Lin Z, Zhao X, Qin Y, Zhou X, Yu XY. Acta Pharm Sin B. 2020 Feb;10(2):313-326. doi: 10.1016/j.apsb.2019.09.003. Epub 2019 Sep 17. PubMed |
| Belinostat resolves skin barrier defects in atopic dermatitis by targeting the dysregulated miR-335:SOX6 axis. Liew WC, Sundaram GM, Quah S, Lum GG, Tan JSL, Ramalingam R, Common JEA, Tang MBY, Lane EB, Thng STG, Sampath P. J Allergy Clin Immunol. 2020 Feb 21. pii: S0091-6749(20)30259-1. doi: 10.1016/j.jaci.2020.02.007. PubMed |
| Association of BRCA Mutations and BRCAness Status With Anticancer Drug Sensitivities in Triple-Negative Breast Cancer Cell Lines Teraoka S, Muguruma M, Takano N, Miyahara K, Kawate T, Kaise H, Yamada K, Miyazawa K, Ishikawa T. J Surg Res. 2020 Jun;250:200-208. doi: 10.1016/j.jss.2019.12.040. Epub 2020 Feb 21. PubMed |
| Studies of Non-Protective Autophagy Provide Evidence that Recovery from Therapy-Induced Senescence is Independent of Early Autophagy. Saleh T, Tyutyunyk-Massey L, Patel NH, Cudjoe EK Jr, Alotaibi M, Gewirtz DA. Int J Mol Sci. 2020 Feb 20;21(4). pii: ijms21041427. doi: 10.3390/ijms21041427. PubMed |
| Optimization of recombinant Zika virus NS1 protein secretion from HEK293 cells. Roldan JS, Cassola A, Castillo DS. Biotechnol Rep (Amst). 2020 Feb 11;25:e00434. doi: 10.1016/j.btre.2020.e00434. eCollection 2020 Mar. PubMed |
| MYC Regulation of D2HGDH and L2HGDH Influences the Epigenome and Epitranscriptome. Qiu Z, Lin AP, Jiang S, Elkashef SM, Myers J, Srikantan S, Sasi B, Cao JZ, Godley LA, Rakheja D, Lyu Y, Zheng S, Madesh M, Shiio Y, Dahia PLM, Aguiar RCT. Cell Chem Biol. 2020 May 21;27(5):538-550.e7. doi: 10.1016/j.chembiol.2020.02.002. Epub 2020 Feb 25. PubMed |
| NOTCH4 maintains quiescent mesenchymal-like breast cancer stem cells via transcriptionally activating SLUG and GAS1 in triple-negative breast cancer. Zhou L, Wang D, Sheng D, Xu J, Chen W, Qin Y, Du R, Yang X, He X, Xie N, Liu S, Zhang L. Theranostics. 2020 Jan 19;10(5):2405-2421. doi: 10.7150/thno.38875. eCollection 2020. PubMed |
| Caloric Restriction Reprograms the Single-Cell Transcriptional Landscape of Rattus Norvegicus Aging. Ma S, Sun S, Geng L, Song M, Wang W, Ye Y, Ji Q, Zou Z, Wang S, He X, Li W, Esteban CR, Long X, Guo G, Chan P, Zhou Q, Belmonte JCI, Zhang W, Qu J, Liu GH. Cell. 2020 Mar 5;180(5):984-1001.e22. doi: 10.1016/j.cell.2020.02.008. Epub 2020 Feb 27. PubMed |
| Mutation-Dependent Pathomechanisms Determine the Phenotype in the Bestrophinopathies. Nachtigal AL, Milenkovic A, Brandl C, Schulz HL, Duerr LMJ, Lang GE, Reiff C, Herrmann P, Kellner U, Weber BHF. Int J Mol Sci. 2020 Feb 26;21(5). pii: ijms21051597. doi: 10.3390/ijms21051597. PubMed |
| Acid Ceramidase Depletion Impairs Neuronal Survival and Induces Morphological Defects in Neurites Associated with Altered Gene Transcription and Sphingolipid Content. Kyriakou K, Lederer CW, Kleanthous M, Drousiotou A, Malekkou A. Int J Mol Sci. 2020 Feb 26;21(5). pii: ijms21051607. doi: 10.3390/ijms21051607. PubMed |
| A CRISPR-Cas9-based reporter system for single-cell detection of extracellular vesicle-mediated functional transfer of RNA. de Jong OG, Murphy DE, Mager I, Willms E, Garcia-Guerra A, Gitz-Francois JJ, Lefferts J, Gupta D, Steenbeek SC, van Rheenen J, El Andaloussi S, Schiffelers RM, Wood MJA, Vader P. Nat Commun. 2020 Feb 28;11(1):1113. doi: 10.1038/s41467-020-14977-8. PubMed |
| Ligand-dependent internalization of Bombyx mori tachykinin-related peptide receptor is regulated by PKC, GRK5 and beta-arrestin2/BmKurtz. He X, Yan L, Wu Q, Zhang G, Zhou N. Biochim Biophys Acta Mol Cell Res. 2020 Jun;1867(6):118690. doi: 10.1016/j.bbamcr.2020.118690. Epub 2020 Feb 26. PubMed |
| Saccharide analog, 2-deoxy-d-glucose enhances 4-1BB-mediated antitumor immunity via PD-L1 deglycosylation. Kim B, Sun R, Oh W, Kim AMJ, Schwarz JR, Lim SO. Mol Carcinog. 2020 Jul;59(7):691-700. doi: 10.1002/mc.23170. Epub 2020 Mar 1. PubMed |
| The E3 Ubiquitin Ligase SIAH1 Targets MyD88 for Proteasomal Degradation During Dengue Virus Infection. Murphy Schafer AR, Smith JL, Pryke KM, DeFilippis VR, Hirsch AJ. Front Microbiol. 2020 Feb 14;11:24. doi: 10.3389/fmicb.2020.00024. eCollection 2020. PubMed |
| A Preclinical Embryonic Zebrafish Xenograft Model to Investigate CAR T Cells In Vivo. Pascoal S, Salzer B, Scheuringer E, Wenninger-Weinzierl A, Sturtzel C, Holter W, Taschner-Mandl S, Lehner M, Distel M. Cancers (Basel). 2020 Feb 29;12(3). pii: cancers12030567. doi: 10.3390/cancers12030567. PubMed |
| gscreend: modelling asymmetric count ratios in CRISPR screens to decrease experiment size and improve phenotype detection. Imkeller K, Ambrosi G, Boutros M, Huber W. Genome Biol. 2020 Mar 2;21(1):53. doi: 10.1186/s13059-020-1939-1. PubMed |
| Plakophilin 3 phosphorylation by ribosomal S6 kinases supports desmosome assembly. Muller L, Rietscher K, Keil R, Neuholz M, Hatzfeld M. J Cell Sci. 2020 Apr 16;133(8). pii: jcs.238295. doi: 10.1242/jcs.238295. PubMed |
| Patient-derived small intestinal myofibroblasts direct perfused, physiologically responsive capillary development in a microfluidic Gut-on-a-Chip Model. Seiler KM, Bajinting A, Alvarado DM, Traore MA, Binkley MM, Goo WH, Lanik WE, Ou J, Ismail U, Iticovici M, King CR, VanDussen KL, Swietlicki EA, Gazit V, Guo J, Luke CJ, Stappenbeck T, Ciorba MA, George SC, Meacham JM, Rubin DC, Good M, Warner BW. Sci Rep. 2020 Mar 2;10(1):3842. doi: 10.1038/s41598-020-60672-5. PubMed |
| Bacteria Boost Mammalian Host NAD Metabolism by Engaging the Deamidated Biosynthesis Pathway. Shats I, Williams JG, Liu J, Makarov MV, Wu X, Lih FB, Deterding LJ, Lim C, Xu X, Randall TA, Lee E, Li W, Fan W, Li JL, Sokolsky M, Kabanov AV, Li L, Migaud ME, Locasale JW, Li X. Cell Metab. 2020 Mar 3;31(3):564-579.e7. doi: 10.1016/j.cmet.2020.02.001. PubMed |
High-Throughput Screens of PAM-Flexible Cas9 Variants for Gene Knockout and Transcriptional Modulation.
Legut M, Daniloski Z, Xue X, McKenzie D, Guo X, Wessels HH, Sanjana NE.
Cell Rep. 2020 Mar 3;30(9):2859-2868.e5. doi: 10.1016/j.celrep.2020.02.010.
PubMed
Associated Plasmids
|
| Early B Cell Factor Activity Controls Developmental and Adaptive Thermogenic Gene Programming in Adipocytes. Angueira AR, Shapira SN, Ishibashi J, Sampat S, Sostre-Colon J, Emmett MJ, Titchenell PM, Lazar MA, Lim HW, Seale P. Cell Rep. 2020 Mar 3;30(9):2869-2878.e4. doi: 10.1016/j.celrep.2020.02.023. PubMed |
| Challenges and Reinterpretation of Antibody-Based Research on Phosphorylation of Tyr(307) on PP2Ac. Mazhar S, Leonard D, Sosa A, Schlatzer D, Thomas D, Narla G. Cell Rep. 2020 Mar 3;30(9):3164-3170.e3. doi: 10.1016/j.celrep.2020.02.012. PubMed |
| Therapeutic potential of KLF2-induced exosomal microRNAs in pulmonary hypertension. Sindi HA, Russomanno G, Satta S, Abdul-Salam VB, Jo KB, Qazi-Chaudhry B, Ainscough AJ, Szulcek R, Jan Bogaard H, Morgan CC, Pullamsetti SS, Alzaydi MM, Rhodes CJ, Piva R, Eichstaedt CA, Grunig E, Wilkins MR, Wojciak-Stothard B. Nat Commun. 2020 Mar 4;11(1):1185. doi: 10.1038/s41467-020-14966-x. PubMed |
| Locally acting transcription factors regulate p53-dependent cis-regulatory element activity. Catizone AN, Uzunbas GK, Celadova P, Kuang S, Bose D, Sammons MA. Nucleic Acids Res. 2020 May 7;48(8):4195-4213. doi: 10.1093/nar/gkaa147. PubMed |
| Serine Biosynthesis Pathway Supports MYC-miR-494-EZH2 Feed-Forward Circuit Necessary to Maintain Metabolic and Epigenetic Reprogramming of Burkitt Lymphoma Cells. Bialopiotrowicz E, Noyszewska-Kania M, Kachamakova-Trojanowska N, Loboda A, Cybulska M, Grochowska A, Kopczynski M, Mikula M, Prochorec-Sobieszek M, Firczuk M, Graczyk-Jarzynka A, Zagozdzon R, Zabek A, Mlynarz P, Dulak J, Gorniak P, Szydlowski M, Pyziak K, Martyka J, Sroka-Porada A, Jablonska E, Polak A, Kowalczyk P, Szumera-Cieckiewicz A, Chapuy B, Rzymski T, Brzozka K, Juszczynski P. Cancers (Basel). 2020 Mar 3;12(3). pii: cancers12030580. doi: 10.3390/cancers12030580. PubMed |
| Cryptochromes modulate E2F family transcription factors. Chan AB, Huber AL, Lamia KA. Sci Rep. 2020 Mar 5;10(1):4077. doi: 10.1038/s41598-020-61087-y. PubMed |
| Modulation of Transient Receptor Potential Channels 3 and 6 Regulates Osteoclast Function with Impact on Trabecular Bone Loss. Klein S, Mentrup B, Timmen M, Sherwood J, Lindemann O, Fobker M, Kronenberg D, Pap T, Raschke MJ, Stange R. Calcif Tissue Int. 2020 Jun;106(6):655-664. doi: 10.1007/s00223-020-00673-8. Epub 2020 Mar 5. PubMed |
| Fluctuation-Based Super-Resolution Traction Force Microscopy. Stubb A, Laine RF, Miihkinen M, Hamidi H, Guzman C, Henriques R, Jacquemet G, Ivaska J. Nano Lett. 2020 Apr 8;20(4):2230-2245. doi: 10.1021/acs.nanolett.9b04083. Epub 2020 Mar 20. PubMed |
| Mutant ACVR1 Arrests Glial Cell Differentiation to Drive Tumorigenesis in Pediatric Gliomas. Fortin J, Tian R, Zarrabi I, Hill G, Williams E, Sanchez-Duffhues G, Thorikay M, Ramachandran P, Siddaway R, Wong JF, Wu A, Apuzzo LN, Haight J, You-Ten A, Snow BE, Wakeham A, Goldhamer DJ, Schramek D, Bullock AN, Dijke PT, Hawkins C, Mak TW. Cancer Cell. 2020 Mar 16;37(3):308-323.e12. doi: 10.1016/j.ccell.2020.02.002. Epub 2020 Mar 5. PubMed |
Blackjack mutations improve the on-target activities of increased fidelity variants of SpCas9 with 5'G-extended sgRNAs.
Kulcsar PI, Talas A, Toth E, Nyeste A, Ligeti Z, Welker Z, Welker E.
Nat Commun. 2020 Mar 6;11(1):1223. doi: 10.1038/s41467-020-15021-5.
PubMed
Associated Plasmids
|
| Interferon inducible GBPs restrict Burkholderia thailandensis motility induced cell-cell fusion. Place DE, Briard B, Samir P, Karki R, Bhattacharya A, Guy CS, Peters JL, Frase S, Vogel P, Neale G, Yamamoto M, Kanneganti TD. PLoS Pathog. 2020 Mar 9;16(3):e1008364. doi: 10.1371/journal.ppat.1008364. eCollection 2020 Mar. PubMed |
| The Peroxisome Proliferator-Activated Receptor alpha- Agonist Gemfibrozil Promotes Defense Against Mycobacterium abscessus Infections. Kim YS, Kim JK, Hanh BTB, Kim SY, Kim HJ, Kim YJ, Jeon SM, Park CR, Oh GT, Park JW, Kim JM, Jang J, Jo EK. Cells. 2020 Mar 6;9(3). pii: cells9030648. doi: 10.3390/cells9030648. PubMed |
| Barrier-to-Autointegration Factor 1 Protects against a Basal cGAS-STING Response. Ma H, Qian W, Bambouskova M, Collins PL, Porter SI, Byrum AK, Zhang R, Artyomov M, Oltz EM, Mosammaparast N, Miner JJ, Diamond MS. mBio. 2020 Mar 10;11(2). pii: mBio.00136-20. doi: 10.1128/mBio.00136-20. PubMed |
| Dishevelled 1-Regulated Superpotent Cancer Stem Cells Mediate Wnt Heterogeneity and Tumor Progression in Hepatocellular Carcinoma. Liao WY, Hsu CC, Chan TS, Yen CJ, Chen WY, Pan HW, Tsai KK. Stem Cell Reports. 2020 Mar 10;14(3):462-477. doi: 10.1016/j.stemcr.2020.02.003. PubMed |
| PIWIL4 Maintains HIV-1 Latency by Enforcing Epigenetically Suppressive Modifications on the 5' Long Terminal Repeat. He Z, Jing S, Yang T, Chen J, Huang F, Zhang W, Peng Z, Liu B, Ma X, Wu L, Pan T, Zhang X, Li L, Cai W, Tang X, Zhang J, Zhang H. J Virol. 2020 May 4;94(10). pii: JVI.01923-19. doi: 10.1128/JVI.01923-19. Print 2020 May 4. PubMed |
| High-Throughput, Temporal and Dose Dependent, Effect of Vitamins and Minerals on Chondrogenesis. Dennis JE, Splawn T, Kean TJ. Front Cell Dev Biol. 2020 Feb 25;8:92. doi: 10.3389/fcell.2020.00092. eCollection 2020. PubMed |
| [A Modified Lentivirus-Based Reporter for Magnetic Separation of Cancer Stem Cells]. Ivanova AE, Kravchenko DS, Chumakov SP. Mol Biol (Mosk). 2020 Jan-Feb;54(1):95-102. doi: 10.31857/S0026898419040049. PubMed |
| Extracellular Redox Regulation of alpha7beta Integrin-Mediated Cell Migration Is Signaled via a Dominant Thiol-Switch. Bergerhausen L, Grosche J, Meissner J, Hecker C, Caliandro MF, Westerhausen C, Kamenac A, Rezaei M, Morgelin M, Poschmann G, Vestweber D, Hanschmann EM, Eble JA. Antioxidants (Basel). 2020 Mar 10;9(3). pii: antiox9030227. doi: 10.3390/antiox9030227. PubMed |
| Genome editing of mutant KRAS through supramolecular polymer-mediated delivery of Cas9 ribonucleoprotein for colorectal cancer therapy. Wan T, Chen Y, Pan Q, Xu X, Kang Y, Gao X, Huang F, Wu C, Ping Y. J Control Release. 2020 Jun 10;322:236-247. doi: 10.1016/j.jconrel.2020.03.015. Epub 2020 Mar 10. PubMed |
| Proteasome inhibitors and Smac mimetics cooperate to induce cell death in diffuse large B-cell lymphoma by stabilizing NOXA and triggering mitochondrial apoptosis. Dietz A, Dalda N, Zielke S, Dittmann J, van Wijk SJL, Vogler M, Fulda S. Int J Cancer. 2020 Sep 1;147(5):1485-1498. doi: 10.1002/ijc.32976. Epub 2020 Apr 8. PubMed |
| Mechanical stretch induces myelin protein loss in oligodendrocytes by activating Erk1/2 in a calcium-dependent manner. Kim J, Adams AA, Gokina P, Zambrano B, Jayakumaran J, Dobrowolski R, Maurel P, Pfister BJ, Kim HA. Glia. 2020 Oct;68(10):2070-2085. doi: 10.1002/glia.23827. Epub 2020 Mar 14. PubMed |
| Detection of Lung Tumor Progression in Mice by Ultrasound Imaging. Ghaddar N, Wang S, Michaud V, Kazimierczak U, Ah-Son N, Koromilas AE. J Vis Exp. 2020 Feb 27;(156). doi: 10.3791/60565. PubMed |
| An epilepsy-associated mutation in the nuclear import receptor KPNA7 reduces nuclear localization signal binding. Oostdyk LT, Wang Z, Zang C, Li H, McConnell MJ, Paschal BM. Sci Rep. 2020 Mar 16;10(1):4844. doi: 10.1038/s41598-020-61369-5. PubMed |
| Genetic Manipulation of Human Intestinal Enteroids Demonstrates the Necessity of a Functional Fucosyltransferase 2 Gene for Secretor-Dependent Human Norovirus Infection. Haga K, Ettayebi K, Tenge VR, Karandikar UC, Lewis MA, Lin SC, Neill FH, Ayyar BV, Zeng XL, Larson G, Ramani S, Atmar RL, Estes MK. mBio. 2020 Mar 17;11(2). pii: mBio.00251-20. doi: 10.1128/mBio.00251-20. PubMed |
| Histone H1 eviction by the histone chaperone SET reduces cell survival following DNA damage. Mandemaker IK, Zhou D, Bruens ST, Dekkers DH, Verschure PJ, Edupuganti RR, Meshorer E, Demmers JAA, Marteijn JA. J Cell Sci. 2020 May 11;133(9). pii: jcs.235473. doi: 10.1242/jcs.235473. PubMed |
| Efficient production of a lentiviral system for displaying Crimean-Congo hemorrhagic fever virus glycoproteins reveals a broad range of cellular susceptibility and neutralization ability. Vasmehjani AA, Salehi-Vaziri M, Azadmanesh K, Nejati A, Pouriayevali MH, Gouya MM, Parsaeian M, Shahmahmoodi S. Arch Virol. 2020 May;165(5):1109-1120. doi: 10.1007/s00705-020-04576-9. Epub 2020 Mar 18. PubMed |
| Isoliquiritigenin Suppressed Esophageal Squamous Carcinoma Growth by Blocking EGFR Activation and Inducing Cell Cycle Arrest. Ye L, Zhang J, Zhang Y, Gu B, Zhu H, Mao X. Biomed Res Int. 2020 Mar 8;2020:9259852. doi: 10.1155/2020/9259852. eCollection 2020. PubMed |
| Scinderin suppresses cell proliferation and predicts the poor prognosis of hepatocellular carcinoma. Zhou B, Chen TW, Jiang YB, Wei XB, Lu CD, Li JJ, Xie D, Cheng SQ. Oncol Lett. 2020 Mar;19(3):2011-2020. doi: 10.3892/ol.2020.11262. Epub 2020 Jan 8. PubMed |
| LRP6-CRISPR prevents activation of hepatic stellate cells and liver fibrogenesis in rats. Yu L, Wang L, Yi H, Wu X. Am J Transl Res. 2020 Feb 15;12(2):397-408. eCollection 2020. PubMed |
| Girdin is a component of the lateral polarity protein network restricting cell dissemination. Biehler C, Wang LT, Sevigny M, Jette A, Gamblin CL, Catterall R, Houssin E, McCaffrey L, Laprise P. PLoS Genet. 2020 Mar 20;16(3):e1008674. doi: 10.1371/journal.pgen.1008674. eCollection 2020 Mar. PubMed |
| Derivation of porcine extraembryonic endoderm-like cells from blastocysts. Li Y, Wu S, Yu Y, Zhang H, Wei R, Lv J, Cai M, Yang X, Zhang Y, Liu Z. Cell Prolif. 2020 Apr;53(4):e12782. doi: 10.1111/cpr.12782. Epub 2020 Mar 20. PubMed |
| Deficiency of DICER reduces the invasion ability of trophoblasts and impairs the pro-angiogenic effect of trophoblast-derived microvesicles. Tang L, Yang M, Qin L, Li X, He G, Liu X, Xu W. J Cell Mol Med. 2020 May;24(9):4915-4930. doi: 10.1111/jcmm.14917. Epub 2020 Mar 21. PubMed |
| Long non-coding RNA GRASLND enhances chondrogenesis via suppression of the interferon type II signaling pathway. Huynh NP, Gloss CC, Lorentz J, Tang R, Brunger JM, McAlinden A, Zhang B, Guilak F. Elife. 2020 Mar 23;9. pii: 49558. doi: 10.7554/eLife.49558. PubMed |
| IL-23 signaling regulation of pro-inflammatory T-cell migration uncovered by phosphoproteomics. Alvarez-Salamero C, Castillo-Gonzalez R, Pastor-Fernandez G, Mariblanca IR, Pino J, Cibrian D, Navarro MN. PLoS Biol. 2020 Mar 23;18(3):e3000646. doi: 10.1371/journal.pbio.3000646. eCollection 2020 Mar. PubMed |
| BRD4 inhibition exerts anti-viral activity through DNA damage-dependent innate immune responses. Wang J, Li GL, Ming SL, Wang CF, Shi LJ, Su BQ, Wu HT, Zeng L, Han YQ, Liu ZH, Jiang DW, Du YK, Li XD, Zhang GP, Yang GY, Chu BB. PLoS Pathog. 2020 Mar 24;16(3):e1008429. doi: 10.1371/journal.ppat.1008429. eCollection 2020 Mar. PubMed |
| The small EF-hand protein CALML4 functions as a critical myosin light chain within the intermicrovillar adhesion complex. Choi MS, Graves MJ, Matoo S, Storad ZA, El Sheikh Idris RA, Weck ML, Smith ZB, Tyska MJ, Crawley SW. J Biol Chem. 2020 Jul 10;295(28):9281-9296. doi: 10.1074/jbc.RA120.012820. Epub 2020 Mar 24. PubMed |
| CRISPR-based gene knockout screens reveal deubiquitinases involved in HIV-1 latency in two Jurkat cell models. Rathore A, Iketani S, Wang P, Jia M, Sahi V, Ho DD. Sci Rep. 2020 Mar 24;10(1):5350. doi: 10.1038/s41598-020-62375-3. PubMed |
| Nek2 kinase displaces distal appendages from the mother centriole prior to mitosis. Viol L, Hata S, Pastor-Peidro A, Neuner A, Murke F, Wuchter P, Ho AD, Giebel B, Pereira G. J Cell Biol. 2020 Mar 2;219(3). pii: 133805. doi: 10.1083/jcb.201907136. PubMed |
| Targeting clinical epigenetic reprogramming for chemoprevention of metabolic and viral hepatocellular carcinoma. Juhling F, Hamdane N, Crouchet E, Li S, El Saghire H, Mukherji A, Fujiwara N, Oudot MA, Thumann C, Saviano A, Roca Suarez AA, Goto K, Masia R, Sojoodi M, Arora G, Aikata H, Ono A, Tabrizian P, Schwartz M, Polyak SJ, Davidson I, Schmidl C, Bock C, Schuster C, Chayama K, Pessaux P, Tanabe KK, Hoshida Y, Zeisel MB, Duong FH, Fuchs BC, Baumert TF. Gut. 2021 Jan;70(1):157-169. doi: 10.1136/gutjnl-2019-318918. Epub 2020 Mar 26. PubMed |
| A20 Restricts Inflammatory Response and Desensitizes Gingival Keratinocytes to Apoptosis. Li Y, Mooney EC, Xia XJ, Gupta N, Sahingur SE. Front Immunol. 2020 Mar 10;11:365. doi: 10.3389/fimmu.2020.00365. eCollection 2020. PubMed |
| MiR-377-3p suppresses colorectal cancer through negative regulation on Wnt/beta-catenin signaling by targeting XIAP and ZEB2. Huang L, Liu Z, Hu J, Luo Z, Zhang C, Wang L, Wang Z. Pharmacol Res. 2020 Jun;156:104774. doi: 10.1016/j.phrs.2020.104774. Epub 2020 Mar 24. PubMed |
| mTORC2/Rac1 Pathway Predisposes Cancer Aggressiveness in IDH1-Mutated Glioma. Liu Y, Lu Y, Li A, Celiku O, Han S, Qian M, Yang C. Cancers (Basel). 2020 Mar 26;12(4). pii: cancers12040787. doi: 10.3390/cancers12040787. PubMed |
| CIC is a critical regulator of neuronal differentiation. Hwang I, Pan H, Yao J, Elemento O, Zheng H, Paik J. JCI Insight. 2020 May 7;5(9). pii: 135826. doi: 10.1172/jci.insight.135826. PubMed |
| RNA helicase DDX21 mediates nucleotide stress responses in neural crest and melanoma cells. Santoriello C, Sporrij A, Yang S, Flynn RA, Henriques T, Dorjsuren B, Custo Greig E, McCall W, Stanhope ME, Fazio M, Superdock M, Lichtig A, Adatto I, Abraham BJ, Kalocsay M, Jurynec M, Zhou Y, Adelman K, Calo E, Zon LI. Nat Cell Biol. 2020 Apr;22(4):372-379. doi: 10.1038/s41556-020-0493-0. Epub 2020 Mar 30. PubMed |
| The nanophthalmos protein TMEM98 inhibits MYRF self-cleavage and is required for eye size specification. Cross SH, Mckie L, Hurd TW, Riley S, Wills J, Barnard AR, Young F, MacLaren RE, Jackson IJ. PLoS Genet. 2020 Apr 1;16(4):e1008583. doi: 10.1371/journal.pgen.1008583. eCollection 2020 Apr. PubMed |
| Impaired differentiation of human induced neural stem cells by TOR1A overexpression. Stengel F, Vulinovic F, Meier B, Grutz K, Klein C, Capetian P. Mol Biol Rep. 2020 May;47(5):3993-4001. doi: 10.1007/s11033-020-05390-x. Epub 2020 Apr 1. PubMed |
| Single-cell analysis of a mutant library generated using CRISPR-guided deaminase in human melanoma cells. Jun S, Lim H, Chun H, Lee JH, Bang D. Commun Biol. 2020 Apr 2;3(1):154. doi: 10.1038/s42003-020-0888-2. PubMed |
| (20S)G-Rh2 Inhibits NF-kappaB Regulated Epithelial-Mesenchymal Transition by Targeting Annexin A2. Wang YS, Li H, Li Y, Zhang S, Jin YH. Biomolecules. 2020 Mar 31;10(4). pii: biom10040528. doi: 10.3390/biom10040528. PubMed |
| Interaction between Epithelial Sodium Channel gamma-Subunit and Claudin-8 Modulates Paracellular Sodium Permeability in Renal Collecting Duct. Sassi A, Wang Y, Chassot A, Komarynets O, Roth I, Olivier V, Crambert G, Dizin E, Boscardin E, Hummler E, Feraille E. J Am Soc Nephrol. 2020 May;31(5):1009-1023. doi: 10.1681/ASN.2019080790. Epub 2020 Apr 3. PubMed |
| Hypoxic Regulation of Mitochondrial Metabolism and Mitophagy in Nucleus Pulposus Cells Is Dependent on HIF-1alpha-BNIP3 Axis. Madhu V, Boneski PK, Silagi E, Qiu Y, Kurland I, Guntur AR, Shapiro IM, Risbud MV. J Bone Miner Res. 2020 Aug;35(8):1504-1524. doi: 10.1002/jbmr.4019. Epub 2020 May 15. PubMed |
| PLX3397 treatment inhibits constitutive CSF1R-induced oncogenic ERK signaling, reduces tumor growth, and metastatic burden in osteosarcoma. Smeester BA, Slipek NJ, Pomeroy EJ, Laoharawee K, Osum SH, Larsson AT, Williams KB, Stratton N, Yamamoto K, Peterson JJ, Rathe SK, Mills LJ, Hudson WA, Crosby MR, Wang M, Rahrmann EP, Moriarity BS, Largaespada DA. Bone. 2020 Jul;136:115353. doi: 10.1016/j.bone.2020.115353. Epub 2020 Apr 3. PubMed |
| Mitochondrial DNA mutations induce mitochondrial biogenesis and increase the tumorigenic potential of Hodgkin and Reed-Sternberg cells. Haumann S, Boix J, Knuever J, Bieling A, Vila Sanjurjo A, Elson JL, Blakely EL, Taylor RW, Riet N, Abken H, Kashkar H, Hornig-Do HT, Wiesner RJ. Carcinogenesis. 2020 Apr 7. pii: 5817053. doi: 10.1093/carcin/bgaa032. PubMed |
| CX3CR1-CD8+ T cells are critical in antitumor efficacy but functionally suppressed in the tumor microenvironment. Yamauchi T, Hoki T, Oba T, Saito H, Attwood K, Sabel MS, Chang AE, Odunsi K, Ito F. JCI Insight. 2020 Apr 23;5(8). pii: 133920. doi: 10.1172/jci.insight.133920. PubMed |
| Roscovitine enhances all-trans retinoic acid (ATRA)-induced nuclear enrichment of an ensemble of activated signaling molecules and augments ATRA-induced myeloid cell differentiation. Rashid A, Duan X, Gao F, Yang M, Yen A. Oncotarget. 2020 Mar 24;11(12):1017-1036. doi: 10.18632/oncotarget.27508. eCollection 2020 Mar 24. PubMed |
| TIE2 Induces Breast Cancer Cell Dormancy and Inhibits the Development of Osteolytic Bone Metastases. Drescher F, Juarez P, Arellano DL, Serafin-Higuera N, Olvera-Rodriguez F, Jimenez S, Licea-Navarro AF, Fournier PG. Cancers (Basel). 2020 Apr 3;12(4). pii: cancers12040868. doi: 10.3390/cancers12040868. PubMed |
| Sphingosine Kinase 1 Regulates the Survival of Breast Cancer Stem Cells and Non-stem Breast Cancer Cells by Suppression of STAT1. Hii LW, Chung FF, Mai CW, Yee ZY, Chan HH, Raja VJ, Dephoure NE, Pyne NJ, Pyne S, Leong CO. Cells. 2020 Apr 4;9(4). pii: cells9040886. doi: 10.3390/cells9040886. PubMed |
| Wireless optogenetics protects against obesity via stimulation of non-canonical fat thermogenesis. Tajima K, Ikeda K, Tanabe Y, Thomson EA, Yoneshiro T, Oguri Y, Ferro MD, Poon ASY, Kajimura S. Nat Commun. 2020 Apr 7;11(1):1730. doi: 10.1038/s41467-020-15589-y. PubMed |
| Electrospun Nanofiber Meshes With Endometrial MSCs Modulate Foreign Body Response by Increased Angiogenesis, Matrix Synthesis, and Anti-Inflammatory Gene Expression in Mice: Implication in Pelvic Floor. Mukherjee S, Darzi S, Paul K, Cousins FL, Werkmeister JA, Gargett CE. Front Pharmacol. 2020 Mar 24;11:353. doi: 10.3389/fphar.2020.00353. eCollection 2020. PubMed |
| Genome-wide CRISPR knockout screens identify ADAMTSL3 and PTEN genes as suppressors of HCC proliferation and metastasis, respectively. Zhou X, Li R, Jing R, Zuo B, Zheng Q. J Cancer Res Clin Oncol. 2020 Jun;146(6):1509-1521. doi: 10.1007/s00432-020-03207-9. Epub 2020 Apr 7. PubMed |
| Genome-wide Screens Implicate Loss of Cullin Ring Ligase 3 in Persistent Proliferation and Genome Instability in TP53-Deficient Cells. Drainas AP, Lambuta RA, Ivanova I, Sercin O, Sarropoulos I, Smith ML, Efthymiopoulos T, Raeder B, Stutz AM, Waszak SM, Mardin BR, Korbel JO. Cell Rep. 2020 Apr 7;31(1):107465. doi: 10.1016/j.celrep.2020.03.029. PubMed |
| Trophectoderm-Specific Knockdown of LIN28 Decreases Expression of Genes Necessary for Cell Proliferation and Reduces Elongation of Sheep Conceptus. Ali A, Stenglein MD, Spencer TE, Bouma GJ, Anthony RV, Winger QA. Int J Mol Sci. 2020 Apr 6;21(7). pii: ijms21072549. doi: 10.3390/ijms21072549. PubMed |
| Gain-of-Function Genetic Alterations of G9a Drive Oncogenesis. Kato S, Weng QY, Insco ML, Chen KY, Muralidhar S, Pozniak J, Diaz JMS, Drier Y, Nguyen N, Lo JA, van Rooijen E, Kemeny LV, Zhan Y, Feng Y, Silkworth W, Powell CT, Liau BB, Xiong Y, Jin J, Newton-Bishop J, Zon LI, Bernstein BE, Fisher DE. Cancer Discov. 2020 Jul;10(7):980-997. doi: 10.1158/2159-8290.CD-19-0532. Epub 2020 Apr 8. PubMed |
| ADAMTS-1 and syndecan-4 intersect in the regulation of cell migration and angiogenesis. Lambert J, Makin K, Akbareian S, Johnson R, Alghamdi AAA, Robinson SD, Edwards DR. J Cell Sci. 2020 Apr 8;133(7). pii: jcs.235762. doi: 10.1242/jcs.235762. PubMed |
| KDM6A-Mediated Expression of the Long Noncoding RNA DINO Causes TP53 Tumor Suppressor Stabilization in Human Papillomavirus 16 E7-Expressing Cells. Sharma S, Munger K. J Virol. 2020 Jun 1;94(12). pii: JVI.02178-19. doi: 10.1128/JVI.02178-19. Print 2020 Jun 1. PubMed |
| A Humanized Lym-1 CAR with Novel DAP10/DAP12 Signaling Domains Demonstrates Reduced Tonic Signaling and Increased Antitumor Activity in B-Cell Lymphoma Models. Zheng L, Ren L, Kouhi A, Khawli LA, Hu P, Kaslow HR, Epstein AL. Clin Cancer Res. 2020 Jul 15;26(14):3694-3706. doi: 10.1158/1078-0432.CCR-19-3417. Epub 2020 Apr 9. PubMed |
| The Role of Membrane Capacitance in Cardiac Impulse Conduction: An Optogenetic Study With Non-excitable Cells Coupled to Cardiomyocytes. De Simone SA, Moyle S, Buccarello A, Dellenbach C, Kucera JP, Rohr S. Front Physiol. 2020 Mar 26;11:194. doi: 10.3389/fphys.2020.00194. eCollection 2020. PubMed |
| Phenotype instability of hepatocyte-like cells produced by direct reprogramming of mesenchymal stromal cells. Orge ID, Gadd VL, Barouh JL, Rossi EA, Carvalho RH, Smith I, Allahdadi KJ, Paredes BD, Silva DN, Damasceno PKF, Sampaio GL, Forbes SJ, Soares MBP, Souza BSF. Stem Cell Res Ther. 2020 Apr 10;11(1):154. doi: 10.1186/s13287-020-01665-z. PubMed |
| miR-206 family is important for mitochondrial and muscle function, but not essential for myogenesis in vitro. Przanowska RK, Sobierajska E, Su Z, Jensen K, Przanowski P, Nagdas S, Kashatus JA, Kashatus DF, Bhatnagar S, Lukens JR, Dutta A. FASEB J. 2020 Jun;34(6):7687-7702. doi: 10.1096/fj.201902855RR. Epub 2020 Apr 11. PubMed |
| TRIM34 restricts HIV-1 and SIV capsids in a TRIM5alpha-dependent manner. Ohainle M, Kim K, Komurlu Keceli S, Felton A, Campbell E, Luban J, Emerman M. PLoS Pathog. 2020 Apr 13;16(4):e1008507. doi: 10.1371/journal.ppat.1008507. eCollection 2020 Apr. PubMed |
| Dissecting the novel partners of nuclear c-Raf and its role in all-trans retinoic acid (ATRA)-induced myeloblastic leukemia cells differentiation. Rashid A, Wang R, Zhang L, Yue J, Yang M, Yen A. Exp Cell Res. 2020 Sep 1;394(1):111989. doi: 10.1016/j.yexcr.2020.111989. Epub 2020 Apr 10. PubMed |
| Merkel cell polyomavirus activates LSD1-mediated blockade of non-canonical BAF to regulate transformation and tumorigenesis. Park DE, Cheng J, McGrath JP, Lim MY, Cushman C, Swanson SK, Tillgren ML, Paulo JA, Gokhale PC, Florens L, Washburn MP, Trojer P, DeCaprio JA. Nat Cell Biol. 2020 May;22(5):603-615. doi: 10.1038/s41556-020-0503-2. Epub 2020 Apr 13. PubMed |
| Identification of tumorigenicity-associated genes in osteosarcoma cell lines based on bioinformatic analysis and experimental validation. Jiang S, Zhou F, Zhang Y, Zhou W, Zhu L, Zhang M, Luo J, Ma R, Xu X, Zhu J, Dong X, Zhang S, Fang J, Sun J, Yang X. J Cancer. 2020 Mar 26;11(12):3623-3633. doi: 10.7150/jca.37393. eCollection 2020. PubMed |
| A Probabilistic Classification Tool for Genetic Subtypes of Diffuse Large B Cell Lymphoma with Therapeutic Implications. Wright GW, Huang DW, Phelan JD, Coulibaly ZA, Roulland S, Young RM, Wang JQ, Schmitz R, Morin RD, Tang J, Jiang A, Bagaev A, Plotnikova O, Kotlov N, Johnson CA, Wilson WH, Scott DW, Staudt LM. Cancer Cell. 2020 Apr 13;37(4):551-568.e14. doi: 10.1016/j.ccell.2020.03.015. PubMed |
| Human cytomegalovirus long noncoding RNA4.9 regulates viral DNA replication. Tai-Schmiedel J, Karniely S, Lau B, Ezra A, Eliyahu E, Nachshon A, Kerr K, Suarez N, Schwartz M, Davison AJ, Stern-Ginossar N. PLoS Pathog. 2020 Apr 15;16(4):e1008390. doi: 10.1371/journal.ppat.1008390. eCollection 2020 Apr. PubMed |
| Hotspots of Aberrant Enhancer Activity in Fibrolamellar Carcinoma Reveal Candidate Oncogenic Pathways and Therapeutic Vulnerabilities. Dinh TA, Sritharan R, Smith FD, Francisco AB, Ma RK, Bunaciu RP, Kanke M, Danko CG, Massa AP, Scott JD, Sethupathy P. Cell Rep. 2020 Apr 14;31(2):107509. doi: 10.1016/j.celrep.2020.03.073. PubMed |
| A high-content RNAi screen reveals multiple roles for long noncoding RNAs in cell division. Stojic L, Lun ATL, Mascalchi P, Ernst C, Redmond AM, Mangei J, Barr AR, Bousgouni V, Bakal C, Marioni JC, Odom DT, Gergely F. Nat Commun. 2020 Apr 15;11(1):1851. doi: 10.1038/s41467-020-14978-7. PubMed |
| Rosuvastatin Enhances VSV-G Lentiviral Transduction of NK Cells via Upregulation of the Low-Density Lipoprotein Receptor. Gong Y, Klein Wolterink RGJ, Janssen I, Groot AJ, Bos GMJ, Germeraad WTV. Mol Ther Methods Clin Dev. 2020 Mar 29;17:634-646. doi: 10.1016/j.omtm.2020.03.017. eCollection 2020 Jun 12. PubMed |
| GATA3 Mediates a Fast, Irreversible Commitment to BMP4-Driven Differentiation in Human Embryonic Stem Cells. Gunne-Braden A, Sullivan A, Gharibi B, Sheriff RSM, Maity A, Wang YF, Edwards A, Jiang M, Howell M, Goldstone R, Wollman R, East P, Santos SDM. Cell Stem Cell. 2020 May 7;26(5):693-706.e9. doi: 10.1016/j.stem.2020.03.005. Epub 2020 Apr 16. PubMed |
| HMCES safeguards replication from oxidative stress and ensures error-free repair. Srivastava M, Su D, Zhang H, Chen Z, Tang M, Nie L, Chen J. EMBO Rep. 2020 Jun 4;21(6):e49123. doi: 10.15252/embr.201949123. Epub 2020 Apr 19. PubMed |
| Selective targeting of the oncogenic KRAS G12S mutant allele by CRISPR/Cas9 induces efficient tumor regression. Gao Q, Ouyang W, Kang B, Han X, Xiong Y, Ding R, Li Y, Wang F, Huang L, Chen L, Wang D, Dong X, Zhang Z, Li Y, Ze B, Hou Y, Yang H, Ma Y, Gu Y, Chao CC. Theranostics. 2020 Apr 6;10(11):5137-5153. doi: 10.7150/thno.42325. eCollection 2020. PubMed |
| A-kinase anchoring protein 8L interacts with mTORC1 and promotes cell growth. Melick CH, Meng D, Jewell JL. J Biol Chem. 2020 Jun 5;295(23):8096-8105. doi: 10.1074/jbc.AC120.012595. Epub 2020 Apr 20. PubMed |
| Allosteric Activators of Protein Phosphatase 2A Display Broad Antitumor Activity Mediated by Dephosphorylation of MYBL2. Morita K, He S, Nowak RP, Wang J, Zimmerman MW, Fu C, Durbin AD, Martel MW, Prutsch N, Gray NS, Fischer ES, Look AT. Cell. 2020 Apr 30;181(3):702-715.e20. doi: 10.1016/j.cell.2020.03.051. Epub 2020 Apr 20. PubMed |
| Specialization for Cell-Free or Cell-to-Cell Spread of BAC-Cloned Human Cytomegalovirus Strains Is Determined by Factors beyond the UL128-131 and RL13 Loci. Schultz EP, Lanchy JM, Day LZ, Yu Q, Peterson C, Preece J, Ryckman BJ. J Virol. 2020 Jun 16;94(13). pii: JVI.00034-20. doi: 10.1128/JVI.00034-20. Print 2020 Jun 16. PubMed |
| Proteasome inhibitor-induced modulation reveals the spliceosome as a specific therapeutic vulnerability in multiple myeloma. Huang HH, Ferguson ID, Thornton AM, Bastola P, Lam C, Lin YT, Choudhry P, Mariano MC, Marcoulis MD, Teo CF, Malato J, Phojanakong PJ, Martin TG 3rd, Wolf JL, Wong SW, Shah N, Hann B, Brooks AN, Wiita AP. Nat Commun. 2020 Apr 22;11(1):1931. doi: 10.1038/s41467-020-15521-4. PubMed |
| Impact of IFN-beta and LIF overexpression on human adipose-derived stem cells properties. Ashja-Arvan M, Dehbashi M, Eslami A, Salehi H, Yoosefi M, Ganjalikhani-Hakemi M. J Cell Physiol. 2020 Apr 23. doi: 10.1002/jcp.29717. PubMed |
| Zikavirus prME Envelope Pseudotyped Human Immunodeficiency Virus Type-1 as a Novel Tool for Glioblastoma-Directed Virotherapy. Kretschmer M, Kadlubowska P, Hoffmann D, Schwalbe B, Auerswald H, Schreiber M. Cancers (Basel). 2020 Apr 18;12(4). pii: cancers12041000. doi: 10.3390/cancers12041000. PubMed |
| Amyloid Precursor Protein (APP) Controls the Expression of the Transcriptional Activator Neuronal PAS Domain Protein 4 (NPAS4) and Synaptic GABA Release. Opsomer R, Contino S, Perrin F, Gualdani R, Tasiaux B, Doyen P, Vergouts M, Vrancx C, Doshina A, Pierrot N, Octave JN, Gailly P, Stanga S, Kienlen-Campard P. eNeuro. 2020 May 28;7(3):ENEURO.0322-19.2020. doi: 10.1523/ENEURO.0322-19.2020. Print 2020 May/Jun. PubMed |
Multiplex T Cell Stimulation Assay Utilizing a T Cell Activation Reporter-Based Detection System.
Mann SE, Zhou Z, Landry LG, Anderson AM, Alkanani AK, Fischer J, Peakman M, Mallone R, Campbell K, Michels AW, Nakayama M.
Front Immunol. 2020 Apr 9;11:633. doi: 10.3389/fimmu.2020.00633. eCollection 2020.
PubMed
Associated Plasmids |
| Myogenic Progenitor Cell Lineage Specification by CRISPR/Cas9-Based Transcriptional Activators. Kwon JB, Vankara A, Ettyreddy AR, Bohning JD, Gersbach CA. Stem Cell Reports. 2020 May 12;14(5):755-769. doi: 10.1016/j.stemcr.2020.03.026. Epub 2020 Apr 23. PubMed |
| Absolute Quantification of Transcription Factors Reveals Principles of Gene Regulation in Erythropoiesis. Gillespie MA, Palii CG, Sanchez-Taltavull D, Shannon P, Longabaugh WJR, Downes DJ, Sivaraman K, Espinoza HM, Hughes JR, Price ND, Perkins TJ, Ranish JA, Brand M. Mol Cell. 2020 Jun 4;78(5):960-974.e11. doi: 10.1016/j.molcel.2020.03.031. Epub 2020 Apr 23. PubMed |
| Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity. He Y, Zhang X, Chang J, Kim HN, Zhang P, Wang Y, Khan S, Liu X, Zhang X, Lv D, Song L, Li W, Thummuri D, Yuan Y, Wiegand JS, Ortiz YT, Budamagunta V, Elisseeff JH, Campisi J, Almeida M, Zheng G, Zhou D. Nat Commun. 2020 Apr 24;11(1):1996. doi: 10.1038/s41467-020-15838-0. PubMed |
| Non-coding somatic mutations converge on the PAX8 pathway in ovarian cancer. Corona RI, Seo JH, Lin X, Hazelett DJ, Reddy J, Fonseca MAS, Abassi F, Lin YG, Mhawech-Fauceglia PY, Shah SP, Huntsman DG, Gusev A, Karlan BY, Berman BP, Freedman ML, Gayther SA, Lawrenson K. Nat Commun. 2020 Apr 24;11(1):2020. doi: 10.1038/s41467-020-15951-0. PubMed |
Selective alanine transporter utilization creates a targetable metabolic niche in pancreatic cancer.
Parker SJ, Amendola CR, Hollinshead KER, Yu Q, Yamamoto K, Encarnacion-Rosado J, Rose RE, LaRue MM, Sohn ASW, Biancur DE, Paulo JA, Gygi SP, Jones DR, Wang H, Philips MR, Bar-Sagi D, Mancias JD, Kimmelman AC.
Cancer Discov. 2020 Apr 27. pii: 2159-8290.CD-19-0959. doi: 10.1158/2159-8290.CD-19-0959.
PubMed
Associated Plasmids |
| Aging-regulated anti-apoptotic long non-coding RNA Sarrah augments recovery from acute myocardial infarction. Trembinski DJ, Bink DI, Theodorou K, Sommer J, Fischer A, van Bergen A, Kuo CC, Costa IG, Schurmann C, Leisegang MS, Brandes RP, Alekseeva T, Brill B, Wietelmann A, Johnson CN, Spring-Connell A, Kaulich M, Werfel S, Engelhardt S, Hirt MN, Yorgan K, Eschenhagen T, Kirchhof L, Hofmann P, Jae N, Wittig I, Hamdani N, Bischof C, Krishnan J, Houtkooper RH, Dimmeler S, Boon RA. Nat Commun. 2020 Apr 27;11(1):2039. doi: 10.1038/s41467-020-15995-2. PubMed |
| Decrease in SHP-1 enhances myometrium remodeling via FAK activation leading to labor. Chen HY, Gao LT, Yuan JQ, Zhang YJ, Liu P, Wang G, Ni X, Liu WN, Gao L. Am J Physiol Endocrinol Metab. 2020 Jun 1;318(6):E930-E942. doi: 10.1152/ajpendo.00068.2020. Epub 2020 Apr 28. PubMed |
| GRAF2, WDR44, and MICAL1 mediate Rab8/10/11-dependent export of E-cadherin, MMP14, and CFTR DeltaF508. Lucken-Ardjomande Hasler S, Vallis Y, Pasche M, McMahon HT. J Cell Biol. 2020 May 4;219(5). pii: 151714. doi: 10.1083/jcb.201811014. PubMed |
| Use of Transabdominal Ultrasound for the detection of intra-peritoneal tumor engraftment and growth in mouse xenografts of epithelial ovarian cancer. Chambers LM, Esakov E, Braley C, AlHilli M, Michener C, Reizes O. PLoS One. 2020 Apr 29;15(4):e0228511. doi: 10.1371/journal.pone.0228511. eCollection 2020. PubMed |
| LSD1-mediated enhancer silencing attenuates retinoic acid signalling during pancreatic endocrine cell development. Vinckier NK, Patel NA, Geusz RJ, Wang A, Wang J, Matta I, Harrington AR, Wortham M, Wetton N, Wang J, Jhala US, Rosenfeld MG, Benner CW, Shih HP, Sander M. Nat Commun. 2020 Apr 29;11(1):2082. doi: 10.1038/s41467-020-16017-x. PubMed |
| lncRNA Neat1 Stimulates Osteoclastogenesis Via Sponging miR-7. Zhang Y, Chen XF, Li J, He F, Li X, Guo Y. J Bone Miner Res. 2020 Apr 30. doi: 10.1002/jbmr.4039. PubMed |
| A novel neurodegenerative spectrum disorder in patients with MLKL deficiency. Faergeman SL, Evans H, Attfield KE, Desel C, Kuttikkatte SB, Sommerlund M, Jensen LT, Frokiaer J, Friese MA, Matthews PM, Luchtenborg C, Brugger B, Oturai AB, Dendrou CA, Fugger L. Cell Death Dis. 2020 May 1;11(5):303. doi: 10.1038/s41419-020-2494-0. PubMed |
| FADD and Caspase-8 Regulate Gut Homeostasis and Inflammation by Controlling MLKL- and GSDMD-Mediated Death of Intestinal Epithelial Cells. Schwarzer R, Jiao H, Wachsmuth L, Tresch A, Pasparakis M. Immunity. 2020 Jun 16;52(6):978-993.e6. doi: 10.1016/j.immuni.2020.04.002. Epub 2020 May 1. PubMed |
| Treatment of cancer cells with Lapatinib negatively regulates general translation and induces stress granules formation. Adjibade P, Simoneau B, Ledoux N, Gauthier WN, Nkurunziza M, Khandjian EW, Mazroui R. PLoS One. 2020 May 4;15(5):e0231894. doi: 10.1371/journal.pone.0231894. eCollection 2020. PubMed |
| TRAF3IP3 negatively regulates cytosolic RNA induced anti-viral signaling by promoting TBK1 K48 ubiquitination. Deng M, Tam JW, Wang L, Liang K, Li S, Zhang L, Guo H, Luo X, Zhang Y, Petrucelli A, Davis BK, Conti BJ, June Brickey W, Ko CC, Lei YL, Sun S, Ting JP. Nat Commun. 2020 May 4;11(1):2193. doi: 10.1038/s41467-020-16014-0. PubMed |
| The Robust Restriction of Zika Virus by Type-I Interferon in A549 Cells Varies by Viral Lineage and Is Not Determined by IFITM3. Gobillot TA, Humes D, Sharma A, Kikawa C, Overbaugh J. Viruses. 2020 May 2;12(5). pii: v12050503. doi: 10.3390/v12050503. PubMed |
| Stem cell delivery to kidney via minimally invasive ultrasound-guided renal artery injection in mice. Zaw Thin M, Ogunlade O, Comenge J, Patrick PS, Stuckey DJ, David AL, Lythgoe MF, Beard P, Kalber TL. Sci Rep. 2020 May 5;10(1):7514. doi: 10.1038/s41598-020-64417-2. PubMed |
| Expression and function of voltage gated proton channels (Hv1) in MDA-MB-231 cells. Bare DJ, Cherny VV, DeCoursey TE, Abukhdeir AM, Morgan D. PLoS One. 2020 May 6;15(5):e0227522. doi: 10.1371/journal.pone.0227522. eCollection 2020. PubMed |
| An Alternative Splicing of Tupaia STING Modulated Anti-RNA Virus Responses by Targeting MDA5-LGP2 and IRF3. Xu L, Yu D, Peng L, Wu Y, Fan Y, Gu T, Yao YL, Zhong J, Chen X, Yao YG. J Immunol. 2020 Jun 15;204(12):3191-3204. doi: 10.4049/jimmunol.1901320. Epub 2020 May 6. PubMed |
Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I.
Yamamoto K, Venida A, Yano J, Biancur DE, Kakiuchi M, Gupta S, Sohn ASW, Mukhopadhyay S, Lin EY, Parker SJ, Banh RS, Paulo JA, Wen KW, Debnath J, Kim GE, Mancias JD, Fearon DT, Perera RM, Kimmelman AC.
Nature. 2020 May;581(7806):100-105. doi: 10.1038/s41586-020-2229-5. Epub 2020 Apr 22.
PubMed
Associated Plasmids |
| Porcine DNAJB6 promotes PCV2 replication via enhancing the formation of autophagy in host cells. Han C, Du Q, Zhu L, Chen N, Luo L, Chen Q, Yin J, Wu X, Tong D, Huang Y. Vet Res. 2020 May 7;51(1):61. doi: 10.1186/s13567-020-00783-z. PubMed |
| Efficient Generation and Correction of Mutations in Human iPS Cells Utilizing mRNAs of CRISPR Base Editors and Prime Editors. Surun D, Schneider A, Mircetic J, Neumann K, Lansing F, Paszkowski-Rogacz M, Hanchen V, Lee-Kirsch MA, Buchholz F. Genes (Basel). 2020 May 6;11(5). pii: genes11050511. doi: 10.3390/genes11050511. PubMed |
| Intramitochondrial proteostasis is directly coupled to alpha-synuclein and amyloid beta1-42 pathologies. Lautenschlager J, Wagner-Valladolid S, Stephens AD, Fernandez-Villegas A, Hockings C, Mishra A, Manton JD, Fantham MJ, Lu M, Rees EJ, Kaminski CF, Kaminski Schierle GS. J Biol Chem. 2020 Jul 24;295(30):10138-10152. doi: 10.1074/jbc.RA119.011650. Epub 2020 May 8. PubMed |
| Biochemical characteristics of the chondrocyte-enriched SNORC protein and its transcriptional regulation by SOX9. Jaiswal PK, Aljebali L, Gaumond MH, Oh CD, Yasuda H, Moffatt P. Sci Rep. 2020 May 8;10(1):7790. doi: 10.1038/s41598-020-64640-x. PubMed |
| Targeted Degradation of SLC Transporters Reveals Amenability of Multi-Pass Transmembrane Proteins to Ligand-Induced Proteolysis. Bensimon A, Pizzagalli MD, Kartnig F, Dvorak V, Essletzbichler P, Winter GE, Superti-Furga G. Cell Chem Biol. 2020 Jun 18;27(6):728-739.e9. doi: 10.1016/j.chembiol.2020.04.003. Epub 2020 May 7. PubMed |
| NFI transcription factors provide chromatin access to maintain stem cell identity while preventing unintended lineage fate choices. Adam RC, Yang H, Ge Y, Infarinato NR, Gur-Cohen S, Miao Y, Wang P, Zhao Y, Lu CP, Kim JE, Ko JY, Paik SS, Gronostajski RM, Kim J, Krueger JG, Zheng D, Fuchs E. Nat Cell Biol. 2020 Jun;22(6):640-650. doi: 10.1038/s41556-020-0513-0. Epub 2020 May 11. PubMed |
| Mucus blocks probiotics but increases penetration of motile pathogens and induces TNF-alpha and IL-8 secretion. Sharma A, Raman V, Lee J, Forbes NS. Biotechnol Bioeng. 2020 Aug;117(8):2540-2555. doi: 10.1002/bit.27383. Epub 2020 Jun 2. PubMed |
| Mitochondrial-related effects of pentabromophenol, tetrabromobisphenol A, and triphenyl phosphate on murine BV-2 microglia cells. Bowen C, Childers G, Perry C, Martin N, McPherson CA, Lauten T, Santos J, Harry GJ. Chemosphere. 2020 Sep;255:126919. doi: 10.1016/j.chemosphere.2020.126919. Epub 2020 Apr 30. PubMed |
| Tob2 phosphorylation regulates global mRNA turnover to reshape transcriptome and impact cell proliferation. Chen CA, Strouz K, Huang KL, Shyu AB. RNA. 2020 Sep;26(9):1143-1159. doi: 10.1261/rna.073528.119. Epub 2020 May 13. PubMed |
| The mRNA Cap 2'-O-Methyltransferase CMTR1 Regulates the Expression of Certain Interferon-Stimulated Genes. Williams GD, Gokhale NS, Snider DL, Horner SM. mSphere. 2020 May 13;5(3). pii: 5/3/e00202-20. doi: 10.1128/mSphere.00202-20. PubMed |
| Patient fibroblast circadian rhythms predict lithium sensitivity in bipolar disorder. Sanghani HR, Jagannath A, Humberstone T, Ebrahimjee F, Thomas JM, Churchill GC, Cipriani A, Attenburrow MJ, Perestenko OV, Cowley SA, Cader MZ, Peirson SN, Harrison PJ, Foster RG, Goodwin GM, Vasudevan SR. Mol Psychiatry. 2020 May 13. pii: 10.1038/s41380-020-0769-6. doi: 10.1038/s41380-020-0769-6. PubMed |
High-affinity mutant Interleukin-13 targeted CAR T cells enhance delivery of clickable biodegradable fluorescent nanoparticles to glioblastoma.
Kim GB, Aragon-Sanabria V, Randolph L, Jiang H, Reynolds JA, Webb BS, Madhankumar A, Lian X, Connor JR, Yang J, Dong C.
Bioact Mater. 2020 May 7;5(3):624-635. doi: 10.1016/j.bioactmat.2020.04.011. eCollection 2020 Sep.
PubMed
Associated Plasmids |
| Schwann cell reprogramming into repair cells increases miRNA-21 expression in exosomes promoting axonal growth. Lopez-Leal R, Diaz-Viraque F, Catalan RJ, Saquel C, Enright A, Iraola G, Court FA. J Cell Sci. 2020 Jun 15;133(12). pii: jcs.239004. doi: 10.1242/jcs.239004. PubMed |
| Laminin-511 and alpha6 integrins regulate the expression of CXCR4 to promote endothelial morphogenesis. Xu H, Pumiglia K, LaFlamme SE. J Cell Sci. 2020 Jun 11;133(11). pii: jcs.246595. doi: 10.1242/jcs.246595. PubMed |
| LINC00261 Is Differentially Expressed in Pancreatic Cancer Subtypes and Regulates a Pro-Epithelial Cell Identity. Dorn A, Glass M, Neu CT, Heydel B, Huttelmaier S, Gutschner T, Haemmerle M. Cancers (Basel). 2020 May 13;12(5). pii: cancers12051227. doi: 10.3390/cancers12051227. PubMed |
| Molecular profiling reveals a hypoxia signature in breast implant-associated anaplastic large cell lymphoma. Oishi N, Hundal T, Phillips JL, Dasari S, Hu G, Viswanatha DS, He R, Mai M, Jacobs HK, Ahmed NH, Syrbu SI, Salama Y, Chapman JR, Vega F, Sidhu J, Bennani NN, Epstein AL, Medeiros LJ, Clemens MW, Miranda RN, Feldman AL. Haematologica. 2020 May 15. pii: haematol.2019.245860. doi: 10.3324/haematol.2019.245860. PubMed |
| Procedures for Culturing and Genetically Manipulating Murine Hippocampal Postnatal Neurons. Moutin E, Hemonnot AL, Seube V, Linck N, Rassendren F, Perroy J, Compan V. Front Synaptic Neurosci. 2020 Apr 30;12:19. doi: 10.3389/fnsyn.2020.00019. eCollection 2020. PubMed |
| ZKSCAN3 counteracts cellular senescence by stabilizing heterochromatin. Hu H, Ji Q, Song M, Ren J, Liu Z, Wang Z, Liu X, Yan K, Hu J, Jing Y, Wang S, Zhang W, Liu GH, Qu J. Nucleic Acids Res. 2020 Jun 19;48(11):6001-6018. doi: 10.1093/nar/gkaa425. PubMed |
| Selective role of Nck1 in atherogenic inflammation and plaque formation. Alfaidi M, Acosta CH, Wang D, Traylor JG, Orr AW. J Clin Invest. 2020 Aug 3;130(8):4331-4347. doi: 10.1172/JCI135552. PubMed |
| Enterovirus 71 induces neural cell apoptosis and autophagy through promoting ACOX1 downregulation and ROS generation. You L, Chen J, Liu W, Xiang Q, Luo Z, Wang W, Xu W, Wu K, Zhang Q, Liu Y, Wu J. Virulence. 2020 Dec;11(1):537-553. doi: 10.1080/21505594.2020.1766790. PubMed |
| HLTF Promotes Fork Reversal, Limiting Replication Stress Resistance and Preventing Multiple Mechanisms of Unrestrained DNA Synthesis. Bai G, Kermi C, Stoy H, Schiltz CJ, Bacal J, Zaino AM, Hadden MK, Eichman BF, Lopes M, Cimprich KA. Mol Cell. 2020 Jun 18;78(6):1237-1251.e7. doi: 10.1016/j.molcel.2020.04.031. Epub 2020 May 21. PubMed |
| Wnt/beta-catenin signaling contributes to prostate cancer heterogeneity through reciprocal suppression of H3K27 trimethylation. Wang F, Zhu Y, Wang F, Wang Y, Dong BJ, Wang N, Gao WQ. Biochem Biophys Res Commun. 2020 Jun 18;527(1):242-249. doi: 10.1016/j.bbrc.2020.04.112. Epub 2020 May 4. PubMed |
| Nucleoporin 153 links nuclear pore complex to chromatin architecture by mediating CTCF and cohesin binding. Kadota S, Ou J, Shi Y, Lee JT, Sun J, Yildirim E. Nat Commun. 2020 May 25;11(1):2606. doi: 10.1038/s41467-020-16394-3. PubMed |
| Ecto-NTPDase CD39 is a negative checkpoint that inhibits follicular helper cell generation. Cao W, Fang F, Gould T, Li X, Kim C, Gustafson C, Lambert S, Weyand CM, Goronzy JJ. J Clin Invest. 2020 Jul 1;130(7):3422-3436. doi: 10.1172/JCI132417. PubMed |
| DNA damage invokes mitophagy through a pathway involving Spata18. Dan X, Babbar M, Moore A, Wechter N, Tian J, Mohanty JG, Croteau DL, Bohr VA. Nucleic Acids Res. 2020 Jul 9;48(12):6611-6623. doi: 10.1093/nar/gkaa393. PubMed |
| Lentivirally administered glial cell line-derived neurotrophic factor promotes post-ischemic neurological recovery, brain remodeling and contralesional pyramidal tract plasticity by regulating axonal growth inhibitors and guidance proteins. Beker M, Caglayan AB, Beker MC, Altunay S, Karacay R, Dalay A, Altintas MO, Kose GT, Hermann DM, Kilic E. Exp Neurol. 2020 May 23;331:113364. doi: 10.1016/j.expneurol.2020.113364. PubMed |
| An Integrated Genomic Strategy to Identify CHRNB4 as a Diagnostic/Prognostic Biomarker for Targeted Therapy in Head and Neck Cancer. Chuang YH, Lee CH, Lin CY, Liu CL, Huang SH, Lee JY, Chiu YY, Lee JC, Yang JM. Cancers (Basel). 2020 May 22;12(5). pii: cancers12051324. doi: 10.3390/cancers12051324. PubMed |
| SIX2 Regulates Human beta Cell Differentiation from Stem Cells and Functional Maturation In Vitro. Velazco-Cruz L, Goedegebuure MM, Maxwell KG, Augsornworawat P, Hogrebe NJ, Millman JR. Cell Rep. 2020 May 26;31(8):107687. doi: 10.1016/j.celrep.2020.107687. PubMed |
| Increased expression of miR142 and miR155 in glial and immune cells after traumatic brain injury may contribute to neuroinflammation via astrocyte activation. Korotkov A, Puhakka N, Gupta SD, Vuokila N, Broekaart DWM, Anink JJ, Heiskanen M, Karttunen J, van Scheppingen J, Huitinga I, Mills JD, van Vliet EA, Pitkanen A, Aronica E. Brain Pathol. 2020 May 27. doi: 10.1111/bpa.12865. PubMed |
| MESH1 is a cytosolic NADPH phosphatase that regulates ferroptosis. Ding CC, Rose J, Sun T, Wu J, Chen PH, Lin CC, Yang WH, Chen KY, Lee H, Xu E, Tian S, Akinwuntan J, Zhao J, Guan Z, Zhou P, Chi JT. Nat Metab. 2020 Mar;2(3):270-277. doi: 10.1038/s42255-020-0181-1. Epub 2020 Mar 9. PubMed |
| STAG1 vulnerabilities for exploiting cohesin synthetic lethality in STAG2-deficient cancers. van der Lelij P, Newman JA, Lieb S, Jude J, Katis V, Hoffmann T, Hinterndorfer M, Bader G, Kraut N, Pearson MA, Peters JM, Zuber J, Gileadi O, Petronczki M. Life Sci Alliance. 2020 May 28;3(7). pii: 3/7/e202000725. doi: 10.26508/lsa.202000725. Print 2020 Jul. PubMed |
| Nck1, But Not Nck2, Mediates Disturbed Flow-Induced p21-Activated Kinase Activation and Endothelial Permeability. Alfaidi M, Bhattarai U, Orr AW. J Am Heart Assoc. 2020 Jun 2;9(11):e016099. doi: 10.1161/JAHA.120.016099. Epub 2020 May 29. PubMed |
| Isolation of Human Small Extracellular Vesicles and Tracking of their Uptake by Retinal Pigment Epithelial Cells In Vitro. Marcu IC, Eberhard N, Yerly A, Balmer V, Hemphill A, Mogel H, Gaschen V, Stoffel MH, Bluteau J. Int J Mol Sci. 2020 May 27;21(11). pii: ijms21113799. doi: 10.3390/ijms21113799. PubMed |
| Establishment of stable Vero cell lines expressing TMPRSS2 and MSPL: A useful tool for propagating porcine epidemic diarrhea virus in the absence of exogenous trypsin. Wang X, Qiao X, Sui L, Zhao H, Li F, Tang YD, Shi W, Guo Y, Jiang Y, Wang L, Zhou H, Tang L, Xu Y, Li Y. Virulence. 2020 Dec;11(1):669-685. doi: 10.1080/21505594.2020.1770491. PubMed |
| miR-486 is involved in the pathogenesis of acute myeloid leukemia by regulating JAK-STAT signaling. Sha C, Jia G, Jingjing Z, Yapeng H, Zhi L, Guanghui X. Naunyn Schmiedebergs Arch Pharmacol. 2020 May 29. pii: 10.1007/s00210-020-01892-4. doi: 10.1007/s00210-020-01892-4. PubMed |
| Chemical modulation of circadian rhythms and assessment of cellular behavior via indirubin and derivatives. Lin HH, Robertson KL, Lellupitiyage Don SS, Taylor SR, Farkas ME. Methods Enzymol. 2020;639:115-140. doi: 10.1016/bs.mie.2020.04.011. Epub 2020 Apr 30. PubMed |
| Frequent upregulation of G9a promotes RelB-dependent proliferation and survival in multiple myeloma. Zhang XY, Rajagopalan D, Chung TH, Hooi L, Toh TB, Tian JS, Rashid MBMA, Sahib NRBM, Gu M, Lim JJ, Wang W, Chng WJ, Jha S, Chow EK. Exp Hematol Oncol. 2020 May 22;9:8. doi: 10.1186/s40164-020-00164-4. eCollection 2020. PubMed |
| Protrudin-mediated ER-endosome contact sites promote MT1-MMP exocytosis and cell invasion. Pedersen NM, Wenzel EM, Wang L, Antoine S, Chavrier P, Stenmark H, Raiborg C. J Cell Biol. 2020 Aug 3;219(8). pii: 151827. doi: 10.1083/jcb.202003063. PubMed |
| CAMK2A supported tumor initiating cells of lung adenocarcinoma by upregulating SOX2 through EZH2 phosphorylation. Wang SQ, Liu J, Qin J, Zhu Y, Tin VP, Yam JWP, Wong MP, Xiao ZJ. Cell Death Dis. 2020 Jun 1;11(6):410. doi: 10.1038/s41419-020-2553-6. PubMed |
| Targeted Perturb-seq enables genome-scale genetic screens in single cells. Schraivogel D, Gschwind AR, Milbank JH, Leonce DR, Jakob P, Mathur L, Korbel JO, Merten CA, Velten L, Steinmetz LM. Nat Methods. 2020 Jun;17(6):629-635. doi: 10.1038/s41592-020-0837-5. Epub 2020 Jun 1. PubMed |
Base editors for simultaneous introduction of C-to-T and A-to-G mutations.
Sakata RC, Ishiguro S, Mori H, Tanaka M, Tatsuno K, Ueda H, Yamamoto S, Seki M, Masuyama N, Nishida K, Nishimasu H, Arakawa K, Kondo A, Nureki O, Tomita M, Aburatani H, Yachie N.
Nat Biotechnol. 2020 Jun 1. pii: 10.1038/s41587-020-0509-0. doi: 10.1038/s41587-020-0509-0.
PubMed
Associated Plasmids |
| Identification of a potent and selective covalent Pin1 inhibitor. Pinch BJ, Doctor ZM, Nabet B, Browne CM, Seo HS, Mohardt ML, Kozono S, Lian X, Manz TD, Chun Y, Kibe S, Zaidman D, Daitchman D, Yeoh ZC, Vangos NE, Geffken EA, Tan L, Ficarro SB, London N, Marto JA, Buratowski S, Dhe-Paganon S, Zhou XZ, Lu KP, Gray NS. Nat Chem Biol. 2020 Sep;16(9):979-987. doi: 10.1038/s41589-020-0550-9. Epub 2020 Jun 1. PubMed |
| Harnessing stemness and PD-L1 expression by AT-rich interaction domain-containing protein 3B in colorectal cancer. Liao TT, Lin CC, Jiang JK, Yang SH, Teng HW, Yang MH. Theranostics. 2020 May 15;10(14):6095-6112. doi: 10.7150/thno.44147. eCollection 2020. PubMed |
| ABL Genomic Editing Sufficiently Abolishes Oncogenesis of Human Chronic Myeloid Leukemia Cells In Vitro and In Vivo. Chen SH, Hsieh YY, Tzeng HE, Lin CY, Hsu KW, Chiang YS, Lin SM, Su MJ, Hsieh WS, Lee CH. Cancers (Basel). 2020 May 29;12(6). pii: cancers12061399. doi: 10.3390/cancers12061399. PubMed |
| A potent CBP/p300-Snail interaction inhibitor suppresses tumor growth and metastasis in wild-type p53-expressing cancer. Li HM, Bi YR, Li Y, Fu R, Lv WC, Jiang N, Xu Y, Ren BX, Chen YD, Xie H, Wang S, Lu T, Wu ZQ. Sci Adv. 2020 Apr 22;6(17):eaaw8500. doi: 10.1126/sciadv.aaw8500. eCollection 2020 Apr. PubMed |
| CD31 (PECAM-1) Serves as the Endothelial Cell-Specific Receptor of Clostridium perfringens beta-Toxin. Bruggisser J, Tarek B, Wyder M, Muller P, von Ballmoos C, Witz G, Enzmann G, Deutsch U, Engelhardt B, Posthaus H. Cell Host Microbe. 2020 Jul 8;28(1):69-78.e6. doi: 10.1016/j.chom.2020.05.003. Epub 2020 Jun 3. PubMed |
| Proximal Biotinylation-Based Combinatory Approach for Isolating Integral Plasma Membrane Proteins. Akdag M, Yunt ZS, Kamacioglu A, Qureshi MH, Akarlar BA, Ozlu N. J Proteome Res. 2020 Aug 7;19(8):3583-3592. doi: 10.1021/acs.jproteome.0c00113. Epub 2020 Jun 15. PubMed |
| MYC functions as a switch for natural killer cell-mediated immune surveillance of lymphoid malignancies. Swaminathan S, Hansen AS, Heftdal LD, Dhanasekaran R, Deutzmann A, Fernandez WDM, Liefwalker DF, Horton C, Mosley A, Liebersbach M, Maecker HT, Felsher DW. Nat Commun. 2020 Jun 5;11(1):2860. doi: 10.1038/s41467-020-16447-7. PubMed |
| SIRT7 antagonizes human stem cell aging as a heterochromatin stabilizer. Bi S, Liu Z, Wu Z, Wang Z, Liu X, Wang S, Ren J, Yao Y, Zhang W, Song M, Liu GH, Qu J. Protein Cell. 2020 Jul;11(7):483-504. doi: 10.1007/s13238-020-00728-4. Epub 2020 Jun 6. PubMed |
Direct-seq: programmed gRNA scaffold for streamlined scRNA-seq in CRISPR screen.
Song Q, Ni K, Liu M, Li Y, Wang L, Wang Y, Liu Y, Yu Z, Qi Y, Lu Z, Ma L.
Genome Biol. 2020 Jun 8;21(1):136. doi: 10.1186/s13059-020-02044-w.
PubMed
Associated Plasmids |
| Modulation of dopamine D1 receptors via histamine H3 receptors is a novel therapeutic target for Huntington's disease. Moreno-Delgado D, Puigdellivol M, Moreno E, Rodriguez-Ruiz M, Botta J, Gasperini P, Chiarlone A, Howell LA, Scarselli M, Casado V, Cortes A, Ferre S, Guzman M, Lluis C, Alberch J, Canela EI, Gines S, McCormick PJ. Elife. 2020 Jun 9;9. pii: 51093. doi: 10.7554/eLife.51093. PubMed |
| Selective Translation of Cell Fate Regulators Mediates Tolerance to Broad Oncogenic Stress. Cai EY, Kufeld MN, Schuster S, Arora S, Larkin M, Germanos AA, Hsieh AC, Beronja S. Cell Stem Cell. 2020 Aug 6;27(2):270-283.e7. doi: 10.1016/j.stem.2020.05.007. Epub 2020 Jun 8. PubMed |
| Endogenous DNA 3' Blocks Are Vulnerabilities for BRCA1 and BRCA2 Deficiency and Are Reversed by the APE2 Nuclease. Alvarez-Quilon A, Wojtaszek JL, Mathieu MC, Patel T, Appel CD, Hustedt N, Rossi SE, Wallace BD, Setiaputra D, Adam S, Ohashi Y, Melo H, Cho T, Gervais C, Munoz IM, Grazzini E, Young JTF, Rouse J, Zinda M, Williams RS, Durocher D. Mol Cell. 2020 Jun 18;78(6):1152-1165.e8. doi: 10.1016/j.molcel.2020.05.021. Epub 2020 Jun 8. PubMed |
Massively parallel Cas13 screens reveal principles for guide RNA design.
Wessels HH, Mendez-Mancilla A, Guo X, Legut M, Daniloski Z, Sanjana NE.
Nat Biotechnol. 2020 Jun;38(6):722-727. doi: 10.1038/s41587-020-0456-9. Epub 2020 Mar 16.
PubMed
Associated Plasmids
|
| Stem Cell Determinant SOX9 Promotes Lineage Plasticity and Progression in Basal-like Breast Cancer. Christin JR, Wang C, Chung CY, Liu Y, Dravis C, Tang W, Oktay MH, Wahl GM, Guo W. Cell Rep. 2020 Jun 9;31(10):107742. doi: 10.1016/j.celrep.2020.107742. PubMed |
| A Novel Function of Sphingosine Kinase 2 in the Metabolism of Sphinga-4,14-Diene Lipids. Couttas TA, Rustam YH, Song H, Qi Y, Teo JD, Chen J, Reid GE, Don AS. Metabolites. 2020 Jun 8;10(6). pii: metabo10060236. doi: 10.3390/metabo10060236. PubMed |
| Viral Transduction of DRG Neurons. Sasaki Y. Methods Mol Biol. 2020;2143:55-62. doi: 10.1007/978-1-0716-0585-1_5. PubMed |
| Effects of Inorganic Arsenic on Human Prostate Stem-Progenitor Cell Transformation, Autophagic Flux Blockade, and NRF2 Pathway Activation. Xie L, Hu WY, Hu DP, Shi G, Li Y, Yang J, Prins GS. Environ Health Perspect. 2020 Jun;128(6):67008. doi: 10.1289/EHP6471. Epub 2020 Jun 11. PubMed |
| Loss of STAT6 leads to anchorage-independent growth and trastuzumab resistance in HER2+ breast cancer cells. DiScala M, Najor MS, Yung T, Morgan D, Abukhdeir AM, Cobleigh MA. PLoS One. 2020 Jun 11;15(6):e0234146. doi: 10.1371/journal.pone.0234146. eCollection 2020. PubMed |
| Targeting FTO Suppresses Cancer Stem Cell Maintenance and Immune Evasion. Su R, Dong L, Li Y, Gao M, Han L, Wunderlich M, Deng X, Li H, Huang Y, Gao L, Li C, Zhao Z, Robinson S, Tan B, Qing Y, Qin X, Prince E, Xie J, Qin H, Li W, Shen C, Sun J, Kulkarni P, Weng H, Huang H, Chen Z, Zhang B, Wu X, Olsen MJ, Muschen M, Marcucci G, Salgia R, Li L, Fathi AT, Li Z, Mulloy JC, Wei M, Horne D, Chen J. Cancer Cell. 2020 Jul 13;38(1):79-96.e11. doi: 10.1016/j.ccell.2020.04.017. Epub 2020 Jun 11. PubMed |
| Transient Primary Cilia Mediate Robust Hedgehog Pathway-Dependent Cell Cycle Control. Ho EK, Tsai AE, Stearns T. Curr Biol. 2020 Jul 20;30(14):2829-2835.e5. doi: 10.1016/j.cub.2020.05.004. Epub 2020 Jun 11. PubMed |
| Rab11b-mediated integrin recycling promotes brain metastatic adaptation and outgrowth. Howe EN, Burnette MD, Justice ME, Schnepp PM, Hedrick V, Clancy JW, Guldner IH, Lamere AT, Li J, Aryal UK, D'Souza-Schorey C, Zartman JJ, Zhang S. Nat Commun. 2020 Jun 15;11(1):3017. doi: 10.1038/s41467-020-16832-2. PubMed |
| Abrogation of PRRSV infectivity by CRISPR-Cas13b-mediated viral RNA cleavage in mammalian cells. Cui J, Techakriengkrai N, Nedumpun T, Suradhat S. Sci Rep. 2020 Jun 15;10(1):9617. doi: 10.1038/s41598-020-66775-3. PubMed |
| Guanylate-binding proteins convert cytosolic bacteria into caspase-4 signaling platforms. Wandel MP, Kim BH, Park ES, Boyle KB, Nayak K, Lagrange B, Herod A, Henry T, Zilbauer M, Rohde J, MacMicking JD, Randow F. Nat Immunol. 2020 Aug;21(8):880-891. doi: 10.1038/s41590-020-0697-2. Epub 2020 Jun 15. PubMed |
| Epstein-Barr Virus LMP1 Promotes Syntenin-1- and Hrs-Induced Extracellular Vesicle Formation for Its Own Secretion To Increase Cell Proliferation and Migration. Nkosi D, Sun L, Duke LC, Patel N, Surapaneni SK, Singh M, Meckes DG Jr. mBio. 2020 Jun 16;11(3). pii: mBio.00589-20. doi: 10.1128/mBio.00589-20. PubMed |
| A conformation-specific ON-switch for controlling CAR T cells with an orally available drug. Zajc CU, Dobersberger M, Schaffner I, Mlynek G, Puhringer D, Salzer B, Djinovic-Carugo K, Steinberger P, De Sousa Linhares A, Yang NJ, Obinger C, Holter W, Traxlmayr MW, Lehner M. Proc Natl Acad Sci U S A. 2020 Jun 30;117(26):14926-14935. doi: 10.1073/pnas.1911154117. Epub 2020 Jun 17. PubMed |
| Heme oxygenase promotes B-Raf-dependent melanosphere formation. Jasmer KJ, Hou J, Mannino P, Cheng J, Hannink M. Pigment Cell Melanoma Res. 2020 Jun 17. doi: 10.1111/pcmr.12905. PubMed |
| The guanine nucleotide exchange factor VAV3 participates in ERBB4-mediated cancer cell migration. Ojala VK, Knittle AM, Kirjalainen P, Merilahti JAM, Kortesoja M, Tvorogov D, Vaparanta K, Lin S, Kast J, Pulliainen AT, Kurppa KJ, Elenius K. J Biol Chem. 2020 Aug 14;295(33):11559-11571. doi: 10.1074/jbc.RA119.010925. Epub 2020 Jun 19. PubMed |
| Proteasome Subunits Differentially Control Myeloma Cell Viability and Proteasome Inhibitor Sensitivity. Shi CX, Zhu YX, Bruins LA, Bonolo de Campos C, Stewart W, Braggio E, Stewart AK. Mol Cancer Res. 2020 Jun 19. pii: 1541-7786.MCR-19-1026. doi: 10.1158/1541-7786.MCR-19-1026. PubMed |
| Ibrutinib is not an effective drug in primografts of TCF3-PBX1. van de Ven C, Boeree A, Stalpers F, Zwaan CM, Den Boer ML. Transl Oncol. 2020 Oct;13(10):100817. doi: 10.1016/j.tranon.2020.100817. Epub 2020 Jun 18. PubMed |
| Long-distance modulation of bystander tumor cells by CD8(+) T cell-secreted IFNgamma. Hoekstra ME, Bornes L, Dijkgraaf FE, Philips D, Pardieck IN, Toebes M, Thommen DS, van Rheenen J, Schumacher TNM. Nat Cancer. 2020 Mar;1(3):291-301. doi: 10.1038/s43018-020-0036-4. Epub 2020 Mar 9. PubMed |
| Generation of Monoclonal iPSC Lines with Stable Cas9 Expression and High Cas9 Activity. Liao JQ, Zhou G, Zhou Y. Methods Mol Biol. 2020 Jun 22. doi: 10.1007/7651_2020_304. PubMed |
| Cell Surface Receptor Identification Using Genome-Scale CRISPR/Cas9 Genetic Screens. Sharma S, Wright GJ. J Vis Exp. 2020 Jun 6;(160). doi: 10.3791/60803. PubMed |
| Crystal structures of human PAICS reveal substrate and product binding of an emerging cancer target. Skerlova J, Unterlass J, Gottmann M, Marttila P, Homan E, Helleday T, Jemth AS, Stenmark P. J Biol Chem. 2020 Aug 14;295(33):11656-11668. doi: 10.1074/jbc.RA120.013695. Epub 2020 Jun 22. PubMed |
| Efficient CRISPR/Cas9 genome editing in a salmonid fish cell line using a lentivirus delivery system. Gratacap RL, Regan T, Dehler CE, Martin SAM, Boudinot P, Collet B, Houston RD. BMC Biotechnol. 2020 Jun 23;20(1):35. doi: 10.1186/s12896-020-00626-x. PubMed |
| Integrated analysis reveals critical glycolytic regulators in hepatocellular carcinoma. Lu C, Fang S, Weng Q, Lv X, Meng M, Zhu J, Zheng L, Hu Y, Gao Y, Wu X, Mao J, Tang B, Zhao Z, Huang L, Ji J. Cell Commun Signal. 2020 Jun 23;18(1):97. doi: 10.1186/s12964-020-00539-4. PubMed |
| miR-151a enhances Slug dependent angiogenesis. Jury D, Daugaard I, Sanders KJ, Hansen LL, Agalliu D, Pedersen IM. Oncotarget. 2020 Jun 9;11(23):2160-2171. doi: 10.18632/oncotarget.27331. eCollection 2020 Jun 9. PubMed |
| Biliverdin Reductase-A Deficiency Brighten and Sensitize Biliverdin-binding Chromoproteins. Kobachi K, Kuno S, Sato S, Sumiyama K, Matsuda M, Terai K. Cell Struct Funct. 2020 Aug 21;45(2):131-141. doi: 10.1247/csf.20010. Epub 2020 Jun 25. PubMed |
| The D614G mutation in SARS-CoV-2 Spike increases transduction of multiple human cell types. Daniloski Z, Guo X, Sanjana NE. bioRxiv. 2020 Jun 15. doi: 10.1101/2020.06.14.151357. PubMed |
| VNUT/SLC17A9, a vesicular nucleotide transporter, regulates osteoblast differentiation. Inoue A, Nakao-Kuroishi K, Kometani-Gunjigake K, Mizuhara M, Shirakawa T, Ito-Sago M, Yasuda K, Nakatomi M, Matsubara T, Tada-Shigeyama Y, Morikawa K, Kokabu S, Kawamoto T. FEBS Open Bio. 2020 Jun 26. doi: 10.1002/2211-5463.12918. PubMed |
| ESRRG and PERM1 Govern Mitochondrial Conversion in Brite/Beige Adipocyte Formation. Muller S, Perdikari A, Dapito DH, Sun W, Wollscheid B, Balaz M, Wolfrum C. Front Endocrinol (Lausanne). 2020 Jun 12;11:387. doi: 10.3389/fendo.2020.00387. eCollection 2020. PubMed |
| Newcastle Disease virus infection activates PI3K/Akt/mTOR and p38 MAPK/Mnk1 pathways to benefit viral mRNA translation via interaction of the viral NP protein and host eIF4E. Zhan Y, Yu S, Yang S, Qiu X, Meng C, Tan L, Song C, Liao Y, Liu W, Sun Y, Ding C. PLoS Pathog. 2020 Jun 30;16(6):e1008610. doi: 10.1371/journal.ppat.1008610. eCollection 2020 Jun. PubMed |
| A FAK/HDAC5 signaling axis controls osteocyte mechanotransduction. Sato T, Verma S, Andrade CDC, Omeara M, Campbell N, Wang JS, Cetinbas M, Lang A, Ausk BJ, Brooks DJ, Sadreyev RI, Kronenberg HM, Lagares D, Uda Y, Pajevic PD, Bouxsein ML, Gross TS, Wein MN. Nat Commun. 2020 Jul 1;11(1):3282. doi: 10.1038/s41467-020-17099-3. PubMed |
| Expression of ncRNAs on the DLK1-DIO3 Locus Is Associated With Basal and Mesenchymal Phenotype in Breast Epithelial Progenitor Cells. Budkova Z, Sigurdardottir AK, Briem E, Bergthorsson JT, Sigurdsson S, Magnusson MK, Traustadottir GA, Gudjonsson T, Hilmarsdottir B. Front Cell Dev Biol. 2020 Jun 16;8:461. doi: 10.3389/fcell.2020.00461. eCollection 2020. PubMed |
| Decipher the complexity of cis-regulatory regions by a modified Cas9. Kirchner S, Reuter S, Westphal A, Mrowka R. PLoS One. 2020 Jul 2;15(7):e0235530. doi: 10.1371/journal.pone.0235530. eCollection 2020. PubMed |
| EXO1 Plays a Carcinogenic Role in Hepatocellular Carcinoma and is related to the regulation of FOXP3. Yang G, Dong K, Zhang Z, Zhang E, Liang B, Chen X, Huang Z. J Cancer. 2020 Jun 16;11(16):4917-4932. doi: 10.7150/jca.40673. eCollection 2020. PubMed |
| Effects of PYRIN-containing Apaf1-like protein 1 on isoflurane-induced postoperative cognitive dysfunction in aged rats. Zhang X, Fan X, Li F, Qiu J, Zhang Y. Mol Med Rep. 2020 Aug;22(2):1391-1399. doi: 10.3892/mmr.2020.11244. Epub 2020 Jun 16. PubMed |
Revealing the Activity of Trimeric G-proteins in Live Cells with a Versatile Biosensor Design.
Maziarz M, Park JC, Leyme A, Marivin A, Garcia-Lopez A, Patel PP, Garcia-Marcos M.
Cell. 2020 Jun 27. pii: S0092-8674(20)30752-2. doi: 10.1016/j.cell.2020.06.020.
PubMed
Associated Plasmids |
| Overexpression of ER Protein Processing and Apoptosis Regulator Genes in Human Embryonic Kidney 293 Cells Improves Gene Therapy Vectors Production. Formas-Oliveira AS, Basilio JS, Rodrigues AF, Coroadinha AS. Biotechnol J. 2020 Jul 8:e1900562. doi: 10.1002/biot.201900562. PubMed |
| Integrated Transcriptome and Network Analysis Reveals Spatiotemporal Dynamics of Calvarial Suturogenesis. Holmes G, Gonzalez-Reiche AS, Lu N, Zhou X, Rivera J, Kriti D, Sebra R, Williams AA, Donovan MJ, Potter SS, Pinto D, Zhang B, van Bakel H, Jabs EW. Cell Rep. 2020 Jul 7;32(1):107871. doi: 10.1016/j.celrep.2020.107871. PubMed |
lentiMPRA and MPRAflow for high-throughput functional characterization of gene regulatory elements.
Gordon MG, Inoue F, Martin B, Schubach M, Agarwal V, Whalen S, Feng S, Zhao J, Ashuach T, Ziffra R, Kreimer A, Georgakopoulous-Soares I, Yosef N, Ye CJ, Pollard KS, Shendure J, Kircher M, Ahituv N.
Nat Protoc. 2020 Aug;15(8):2387-2412. doi: 10.1038/s41596-020-0333-5. Epub 2020 Jul 8.
PubMed
Associated Plasmids |
| An adipokine feedback regulating diurnal food intake rhythms in mice. Tsang AH, Koch CE, Kiehn JT, Schmidt CX, Oster H. Elife. 2020 Jul 9;9. pii: 55388. doi: 10.7554/eLife.55388. PubMed |
| Transcriptional repression of PTEN in neural cells using CRISPR/dCas9 epigenetic editing. Moses C, Hodgetts SI, Nugent F, Ben-Ary G, Park KK, Blancafort P, Harvey AR. Sci Rep. 2020 Jul 9;10(1):11393. doi: 10.1038/s41598-020-68257-y. PubMed |
| A Genetic Map of the Response to DNA Damage in Human Cells. Olivieri M, Cho T, Alvarez-Quilon A, Li K, Schellenberg MJ, Zimmermann M, Hustedt N, Rossi SE, Adam S, Melo H, Heijink AM, Sastre-Moreno G, Moatti N, Szilard RK, McEwan A, Ling AK, Serrano-Benitez A, Ubhi T, Feng S, Pawling J, Delgado-Sainz I, Ferguson MW, Dennis JW, Brown GW, Cortes-Ledesma F, Williams RS, Martin A, Xu D, Durocher D. Cell. 2020 Jul 23;182(2):481-496.e21. doi: 10.1016/j.cell.2020.05.040. Epub 2020 Jul 9. PubMed |
| Microtubule motor transport in the delivery of melanosomes to the actin-rich apical domain of the retinal pigment epithelium. Jiang M, Paniagua AE, Volland S, Wang H, Balaji A, Li DG, Lopes VS, Burgess BL, Williams DS. J Cell Sci. 2020 Aug 4;133(15). pii: jcs.242214. doi: 10.1242/jcs.242214. PubMed |
| Ribosome Recycling by ABCE1 Links Lysosomal Function and Iron Homeostasis to 3' UTR-Directed Regulation and Nonsense-Mediated Decay. Zhu X, Zhang H, Mendell JT. Cell Rep. 2020 Jul 14;32(2):107895. doi: 10.1016/j.celrep.2020.107895. PubMed |
| Macrophage Exosomes Resolve Atherosclerosis by Regulating Hematopoiesis and Inflammation via MicroRNA Cargo. Bouchareychas L, Duong P, Covarrubias S, Alsop E, Phu TA, Chung A, Gomes M, Wong D, Meechoovet B, Capili A, Yamamoto R, Nakauchi H, McManus MT, Carpenter S, Van Keuren-Jensen K, Raffai RL. Cell Rep. 2020 Jul 14;32(2):107881. doi: 10.1016/j.celrep.2020.107881. PubMed |
| Single point mutations within the Coxsackie B virus receptor-binding site promote resistance against soluble virus receptor traps. Pinkert S, Kopp A, Bruckner V, Fechner H, Beling A. J Virol. 2020 Jul 15. pii: JVI.00952-20. doi: 10.1128/JVI.00952-20. PubMed |
| Nuclear role for human Argonaute-1 as an estrogen-dependent transcription coactivator. Gomez Acuna LI, Nazer E, Rodriguez-Segui SA, Pozzi B, Buggiano V, Marasco LE, Agirre E, He C, Allo M, Kornblihtt AR. J Cell Biol. 2020 Sep 7;219(9). pii: 151953. doi: 10.1083/jcb.201908097. PubMed |
| Beclin1 Binds to Enterovirus 71 3D Protein to Promote the Virus Replication. Xiang Q, Wan P, Yang G, Huang S, Qin M, Yang H, Luo Z, Wu K, Wu J. Viruses. 2020 Jul 14;12(7). pii: v12070756. doi: 10.3390/v12070756. PubMed |
| Tuning the Expression of Long Noncoding RNA Loci with CRISPR Interference. Stojic L. Methods Mol Biol. 2020;2161:1-16. doi: 10.1007/978-1-0716-0680-3_1. PubMed |
| Tandem CAR-T cells targeting CD70 and B7-H3 exhibit potent preclinical activity against multiple solid tumors. Yang M, Tang X, Zhang Z, Gu L, Wei H, Zhao S, Zhong K, Mu M, Huang C, Jiang C, Xu J, Guo G, Zhou L, Tong A. Theranostics. 2020 Jun 18;10(17):7622-7634. doi: 10.7150/thno.43991. eCollection 2020. PubMed |
| Engineering Circulating Tumor Cells as Novel Cancer Theranostics. Parkins KM, Dubois VP, Kelly JJ, Chen Y, Knier NN, Foster PJ, Ronald JA. Theranostics. 2020 Jun 29;10(17):7925-7937. doi: 10.7150/thno.44259. eCollection 2020. PubMed |
| Inhibition of the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) stimulates osteoblastogenesis by potentiating bone morphogenetic protein 2 (BMP2) responses. Farhat T, Dudakovic A, Chung JH, van Wijnen AJ, St-Arnaud R. J Cell Physiol. 2020 Jul 19. doi: 10.1002/jcp.29927. PubMed |
| Redox Regulation of PPARgamma in Polarized Macrophages. Trumper V, Wittig I, Heidler J, Richter F, Brune B, von Knethen A. PPAR Res. 2020 Jul 1;2020:8253831. doi: 10.1155/2020/8253831. eCollection 2020. PubMed |
| Conversion of Neural Stem Cells into Functional Neuron-Like Cells by MicroRNA-218: Differential Expression of Functionality Genes. Khalil W, Tiraihi T, Soleimani M, Baheiraei N, Zibara K. Neurotox Res. 2020 Jul 21. pii: 10.1007/s12640-020-00244-7. doi: 10.1007/s12640-020-00244-7. PubMed |
Structural Insights into the SPRED1-Neurofibromin-KRAS Complex and Disruption of SPRED1-Neurofibromin Interaction by Oncogenic EGFR.
Yan W, Markegard E, Dharmaiah S, Urisman A, Drew M, Esposito D, Scheffzek K, Nissley DV, McCormick F, Simanshu DK.
Cell Rep. 2020 Jul 21;32(3):107909. doi: 10.1016/j.celrep.2020.107909.
PubMed
Associated Plasmids |
| SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2. Clausen TM, Sandoval DR, Spliid CB, Pihl J, Painter CD, Thacker BE, Glass CA, Narayanan A, Majowicz SA, Zhang Y, Torres JL, Golden GJ, Porell R, Garretson AF, Laubach L, Feldman J, Yin X, Pu Y, Hauser B, Caradonna TM, Kellman BP, Martino C, Gordts PLSM, Leibel SL, Chanda SK, Schmidt AG, Godula K, Jose J, Corbett KD, Ward AB, Carlin AF, Esko JD. bioRxiv. 2020 Jul 14. doi: 10.1101/2020.07.14.201616. PubMed |
| The CDK4/6-EZH2 pathway is a potential therapeutic target for psoriasis. Muller A, Dickmanns A, Resch C, Schakel K, Hailfinger S, Dobbelstein M, Schulze-Osthoff K, Kramer D. J Clin Invest. 2020 Jul 23. pii: 134217. doi: 10.1172/JCI134217. PubMed |
| Intraductal Transplantation Models of Human Pancreatic Ductal Adenocarcinoma Reveal Progressive Transition of Molecular Subtypes. Miyabayashi K, Baker LA, Deschenes A, Traub B, Caligiuri G, Plenker D, Alagesan B, Belleau P, Li S, Kendall J, Jang GH, Kawaguchi RK, Somerville TDD, Tiriac H, Hwang CI, Burkhart RA, Roberts NJ, Wood LD, Hruban RH, Gillis J, Krasnitz A, Vakoc CR, Wigler M, Notta F, Gallinger S, Park Y, Tuveson DA. Cancer Discov. 2020 Oct;10(10):1566-1589. doi: 10.1158/2159-8290.CD-20-0133. Epub 2020 Jul 23. PubMed |
| PI3K-targeting strategy using alpelisib to enhance the antitumor effect of paclitaxel in human gastric cancer. Kim KJ, Kim JW, Sung JH, Suh KJ, Lee JY, Kim SH, Lee JO, Kim JW, Kim YJ, Kim JH, Bang SM, Lee JS, Kim HK, Lee KW. Sci Rep. 2020 Jul 23;10(1):12308. doi: 10.1038/s41598-020-68998-w. PubMed |
| Dianhydrogalactitol synergizes with topoisomerase poisons to overcome DNA repair activity in tumor cells. Zhai B, Li Y, Kotapalli SS, Bacha J, Brown D, Steino A, Daugaard M. Cell Death Dis. 2020 Jul 24;11(7):577. doi: 10.1038/s41419-020-02780-8. PubMed |
| Loss-of-Function Mutation in PTPN2 Causes Aberrant Activation of JAK Signaling Via STAT and Very Early Onset Intestinal Inflammation. Parlato M, Nian Q, Charbit-Henrion F, Ruemmele FM, Rodrigues-Lima F, Cerf-Bensussan N. Gastroenterology. 2020 Nov;159(5):1968-1971.e4. doi: 10.1053/j.gastro.2020.07.040. Epub 2020 Jul 25. PubMed |
| Derivation and Characterization of Immortalized Human Muscle Satellite Cell Clones from Muscular Dystrophy Patients and Healthy Individuals. Massenet J, Gitiaux C, Magnan M, Cuvellier S, Hubas A, Nusbaum P, Dilworth FJ, Desguerre I, Chazaud B. Cells. 2020 Jul 26;9(8). pii: cells9081780. doi: 10.3390/cells9081780. PubMed |
| Srag Regulates Autophagy via Integrating into a Preexisting Autophagy Pathway in Testis. Cheng Y, Lai F, Wang X, Shang D, Zou J, Luo M, Xia X, Cheng H, Zhou R. Mol Biol Evol. 2021 Jan 4;38(1):128-141. doi: 10.1093/molbev/msaa195. PubMed |
| IGF2BP3 and miR191-5p synergistically increase HCC cell invasiveness by altering ZO-1 expression. Gao Y, Luo T, Ouyang X, Zhu C, Zhu J, Qin X. Oncol Lett. 2020 Aug;20(2):1423-1431. doi: 10.3892/ol.2020.11693. Epub 2020 May 30. PubMed |
| An ErbB2 splice variant lacking exon 16 drives lung carcinoma. Smith HW, Yang L, Ling C, Walsh A, Martinez VD, Boucher J, Zuo D, Sokol ES, Pavlick DC, Frampton GM, Chmielecki J, Jones LM, Roux PP, Lockwood WW, Muller WJ. Proc Natl Acad Sci U S A. 2020 Aug 18;117(33):20139-20148. doi: 10.1073/pnas.2007474117. Epub 2020 Jul 29. PubMed |
| An Optimized Protocol for Human Direct Cardiac Reprogramming. Garbutt TA, Zhou Y, Keepers B, Liu J, Qian L. STAR Protoc. 2020 Jun 19;1(1). doi: 10.1016/j.xpro.2019.100010. Epub 2020 Jun 3. PubMed |
| Alix and Syntenin-1 direct amyloid precursor protein trafficking into extracellular vesicles. Cone AS, Hurwitz SN, Lee GS, Yuan X, Zhou Y, Li Y, Meckes DG Jr. BMC Mol Cell Biol. 2020 Jul 30;21(1):58. doi: 10.1186/s12860-020-00302-0. PubMed |
| Lentiviral gene therapy vectors encoding VIP suppressed diabetes-related inflammation and augmented pancreatic beta-cell proliferation. Erendor F, Sahin EO, Sanlioglu AD, Balci MK, Griffith TS, Sanlioglu S. Gene Ther. 2021 Apr;28(3-4):130-141. doi: 10.1038/s41434-020-0183-3. Epub 2020 Jul 30. PubMed |
| Elevating Insulin Signaling Using a Constitutively Active Insulin Receptor Increases Glucose Metabolism and Expression of GLUT3 in Hippocampal Neurons. Frazier HN, Ghoweri AO, Anderson KL, Lin RL, Popa GJ, Mendenhall MD, Reagan LP, Craven RJ, Thibault O. Front Neurosci. 2020 Jul 7;14:668. doi: 10.3389/fnins.2020.00668. eCollection 2020. PubMed |
| The potency of hsa-miR-9-1 overexpression in photoreceptor differentiation of conjunctiva mesenchymal stem cells on a 3D nanofibrous scaffold. Rahmani A, Naderi M, Barati G, Arefian E, Jedari B, Nadri S. Biochem Biophys Res Commun. 2020 Aug 27;529(3):526-532. doi: 10.1016/j.bbrc.2020.06.006. Epub 2020 Jul 14. PubMed |
| LIM-Nebulette Reinforces Podocyte Structural Integrity by Linking Actin and Vimentin Filaments. Ge X, Zhang T, Yu X, Muwonge AN, Anandakrishnan N, Wong NJ, Haydak JC, Reid JM, Fu J, Wong JS, Bhattacharya S, Cuttitta CM, Zhong F, Gordon RE, Salem F, Janssen W, Hone JC, Zhang A, Li H, He JC, Gusella GL, Campbell KN, Azeloglu EU. J Am Soc Nephrol. 2020 Oct;31(10):2372-2391. doi: 10.1681/ASN.2019121261. Epub 2020 Jul 31. PubMed |
| KRAB domain of ZFP568 disrupts TRIM28-mediated abnormal interactions in cancer cells. Kumar J, Kaur G, Ren R, Lu Y, Lin K, Li J, Huang Y, Patel A, Barton MC, Macfarlan T, Zhang X, Cheng X. NAR Cancer. 2020 Jun;2(2):zcaa007. doi: 10.1093/narcan/zcaa007. Epub 2020 May 18. PubMed |
| Rapid generation of circulating and mucosal decoy ACE2 using mRNA nanotherapeutics for the potential treatment of SARS-CoV-2. Kim J, Mukherjee A, Nelson D, Jozic A, Sahay G. bioRxiv. 2020 Jul 25. doi: 10.1101/2020.07.24.205583. PubMed |
| A human ESC-based screen identifies a role for the translated lncRNA LINC00261 in pancreatic endocrine differentiation. Gaertner B, van Heesch S, Schneider-Lunitz V, Schulz JF, Witte F, Blachut S, Nguyen S, Wong R, Matta I, Hubner N, Sander M. Elife. 2020 Aug 3;9. pii: 58659. doi: 10.7554/eLife.58659. PubMed |
| Rational discovery of molecular glue degraders via scalable chemical profiling. Mayor-Ruiz C, Bauer S, Brand M, Kozicka Z, Siklos M, Imrichova H, Kaltheuner IH, Hahn E, Seiler K, Koren A, Petzold G, Fellner M, Bock C, Muller AC, Zuber J, Geyer M, Thoma NH, Kubicek S, Winter GE. Nat Chem Biol. 2020 Nov;16(11):1199-1207. doi: 10.1038/s41589-020-0594-x. Epub 2020 Aug 3. PubMed |
| Multi-modal imaging probe for assessing the efficiency of stem cell delivery to orthotopic breast tumours. Zaw Thin M, Allan H, Bofinger R, Kostelec TD, Guillaume S, Connell JJ, Patrick PS, Hailes HC, Tabor AB, Lythgoe MF, Stuckey DJ, Kalber TL. Nanoscale. 2020 Aug 13;12(31):16570-16585. doi: 10.1039/d0nr03237a. PubMed |
Multiplexed Optical Sensors in Arrayed Islands of Cells for multimodal recordings of cellular physiology.
Werley CA, Boccardo S, Rigamonti A, Hansson EM, Cohen AE.
Nat Commun. 2020 Aug 4;11(1):3881. doi: 10.1038/s41467-020-17607-5.
PubMed
Associated Plasmids |
| Saffron Crudes and Compounds Restrict MACC1-Dependent Cell Proliferation and Migration of Colorectal Cancer Cells. Gullu N, Kobelt D, Brim H, Rahman S, Timm L, Smith J, Soleimani A, Di Marco S, Bisti S, Ashktorab H, Stein U. Cells. 2020 Aug 3;9(8). pii: cells9081829. doi: 10.3390/cells9081829. PubMed |
| The oncofetal RNA-binding protein IGF2BP1 is a druggable, post-transcriptional super-enhancer of E2F-driven gene expression in cancer. Muller S, Bley N, Busch B, Glass M, Lederer M, Misiak C, Fuchs T, Wedler A, Haase J, Bertoldo JB, Michl P, Huttelmaier S. Nucleic Acids Res. 2020 Sep 4;48(15):8576-8590. doi: 10.1093/nar/gkaa653. PubMed |
| Direct analysis of brain phenotypes via neural blastocyst complementation. Dai HQ, Liang Z, Chang AN, Chapdelaine-Williams AM, Alvarado B, Pollen AA, Alt FW, Schwer B. Nat Protoc. 2020 Oct;15(10):3154-3181. doi: 10.1038/s41596-020-0364-y. Epub 2020 Aug 10. PubMed |
| Dorsoventral polarity directs cell responses to migration track geometries. Wisniewski EO, Mistriotis P, Bera K, Law RA, Zhang J, Nikolic M, Weiger M, Parlani M, Tuntithavornwat S, Afthinos A, Zhao R, Wirtz D, Kalab P, Scarcelli G, Friedl P, Konstantopoulos K. Sci Adv. 2020 Jul 31;6(31):eaba6505. doi: 10.1126/sciadv.aba6505. eCollection 2020 Jul. PubMed |
| Tetraspanin-7 regulation of L-type voltage-dependent calcium channels controls pancreatic beta-cell insulin secretion. Dickerson MT, Dadi PK, Butterworth RB, Nakhe AY, Graff SM, Zaborska KE, Schaub CM, Jacobson DA. J Physiol. 2020 Nov;598(21):4887-4905. doi: 10.1113/JP279941. Epub 2020 Sep 1. PubMed |
| Rapid generation of regionally specified CNS neurons by sequential patterning and conversion of human induced pluripotent stem cells. Chen M, Maimaitili M, Habekost M, Gill KP, Mermet-Joret N, Nabavi S, Febbraro F, Denham M. Stem Cell Res. 2020 Oct;48:101945. doi: 10.1016/j.scr.2020.101945. Epub 2020 Aug 3. PubMed |
| A novel approach to genetic engineering of T-cell subsets by hematopoietic stem cell infection with a bicistronic lentivirus. Bogert NV, Furkel J, Din S, Braren I, Eckstein V, Muller JA, Uhlmann L, Katus HA, Konstandin MH. Sci Rep. 2020 Aug 13;10(1):13740. doi: 10.1038/s41598-020-70793-6. PubMed |
| Splicing variation of BMP2K balances abundance of COPII assemblies and autophagic degradation in erythroid cells. Cendrowski J, Kaczmarek M, Mazur M, Kuzmicz-Kowalska K, Jastrzebski K, Brewinska-Olchowik M, Kominek A, Piwocka K, Miaczynska M. Elife. 2020 Aug 14;9. pii: 58504. doi: 10.7554/eLife.58504. PubMed |
A multiplexed bioluminescent reporter for sensitive and non-invasive tracking of DNA double strand break repair dynamics in vitro and in vivo.
Chien JC, Tabet E, Pinkham K, da Hora CC, Chang JC, Lin S, Badr CE, Lai CP.
Nucleic Acids Res. 2020 Aug 14. pii: 5892751. doi: 10.1093/nar/gkaa669.
PubMed
Associated Plasmids |
| Discovery of a molecular glue promoting CDK12-DDB1 interaction to trigger cyclin K degradation. Lv L, Chen P, Cao L, Li Y, Zeng Z, Cui Y, Wu Q, Li J, Wang JH, Dong MQ, Qi X, Han T. Elife. 2020 Aug 17;9. pii: 59994. doi: 10.7554/eLife.59994. PubMed |
| Methods for the Study of Long Noncoding RNA in Cancer Cell Signaling. Feng Y, Jiang J, Hu Z, Yuan J, Zhang T, Pan Y, Xu M, Li C, Zhang Y, Zhang L, Hu X. Methods Mol Biol. 2021;2174:89-118. doi: 10.1007/978-1-0716-0759-6_7. PubMed |
| Age-induced accumulation of methylmalonic acid promotes tumour progression. Gomes AP, Ilter D, Low V, Endress JE, Fernandez-Garcia J, Rosenzweig A, Schild T, Broekaert D, Ahmed A, Planque M, Elia I, Han J, Kinzig C, Mullarky E, Mutvei AP, Asara J, de Cabo R, Cantley LC, Dephoure N, Fendt SM, Blenis J. Nature. 2020 Sep;585(7824):283-287. doi: 10.1038/s41586-020-2630-0. Epub 2020 Aug 19. PubMed |
| TNF-alpha suppresses SHOX2 expression via NF-kappaB signaling pathway and promotes intervertebral disc degeneration and related pain in a rat model. Ye F, Xu Y, Lin F, Zheng Z. J Orthop Res. 2020 Aug 20. doi: 10.1002/jor.24832. PubMed |
| Safe CRISPR-Cas9 Inhibition of HIV-1 with High Specificity and Broad-Spectrum Activity by Targeting LTR NF-kappaB Binding Sites. Chung CH, Allen AG, Atkins AJ, Sullivan NT, Homan G, Costello R, Madrid R, Nonnemacher MR, Dampier W, Wigdahl B. Mol Ther Nucleic Acids. 2020 Sep 4;21:965-982. doi: 10.1016/j.omtn.2020.07.016. Epub 2020 Jul 15. PubMed |
| SRSF1 regulates exosome microRNA enrichment in human cancer cells. Xu YF, Xu X, Gin A, Nshimiyimana JD, Mooers BHM, Caputi M, Hannafon BN, Ding WQ. Cell Commun Signal. 2020 Aug 20;18(1):130. doi: 10.1186/s12964-020-00615-9. PubMed |
| Engineering AvidCARs for combinatorial antigen recognition and reversible control of CAR function. Salzer B, Schueller CM, Zajc CU, Peters T, Schoeber MA, Kovacic B, Buri MC, Lobner E, Dushek O, Huppa JB, Obinger C, Putz EM, Holter W, Traxlmayr MW, Lehner M. Nat Commun. 2020 Aug 20;11(1):4166. doi: 10.1038/s41467-020-17970-3. PubMed |
| WIP Modulates Oxidative Stress through NRF2/KEAP1 in Glioblastoma Cells. Escoll M, Lastra D, Robledinos-Anton N, Wandosell F, Anton IM, Cuadrado A. Antioxidants (Basel). 2020 Aug 20;9(9). pii: antiox9090773. doi: 10.3390/antiox9090773. PubMed |
| Integrative protocols for an in vitro generation of pancreatic progenitors from human dental pulp stem cells. Sawangmake C, Rodprasert W, Osathanon T, Pavasant P. Biochem Biophys Res Commun. 2020 Sep 10;530(1):222-229. doi: 10.1016/j.bbrc.2020.06.145. Epub 2020 Aug 3. PubMed |
| Profiling of immune related genes silenced in EBV-positive gastric carcinoma identified novel restriction factors of human gammaherpesviruses. Fiches GN, Zhou D, Kong W, Biswas A, Ahmed EH, Baiocchi RA, Zhu J, Santoso N. PLoS Pathog. 2020 Aug 25;16(8):e1008778. doi: 10.1371/journal.ppat.1008778. eCollection 2020 Aug. PubMed |
Phase Separation of a PKA Regulatory Subunit Controls cAMP Compartmentation and Oncogenic Signaling.
Zhang JZ, Lu TW, Stolerman LM, Tenner B, Yang JR, Zhang JF, Falcke M, Rangamani P, Taylor SS, Mehta S, Zhang J.
Cell. 2020 Sep 17;182(6):1531-1544.e15. doi: 10.1016/j.cell.2020.07.043. Epub 2020 Aug 25.
PubMed
Associated Plasmids |
| Altered 3D chromatin structure permits inversional recombination at the IgH locus. Qiu X, Ma F, Zhao M, Cao Y, Shipp L, Liu A, Dutta A, Singh A, Braikia FZ, De S, Wood WH 3rd, Becker KG, Zhou W, Ji H, Zhao K, Atchison ML, Sen R. Sci Adv. 2020 Aug 14;6(33):eaaz8850. doi: 10.1126/sciadv.aaz8850. eCollection 2020 Aug. PubMed |
| A cross-kingdom conserved ER-phagy receptor maintains endoplasmic reticulum homeostasis during stress. Stephani M, Picchianti L, Gajic A, Beveridge R, Skarwan E, Sanchez de Medina Hernandez V, Mohseni A, Clavel M, Zeng Y, Naumann C, Matuszkiewicz M, Turco E, Loefke C, Li B, Durnberger G, Schutzbier M, Chen HT, Abdrakhmanov A, Savova A, Chia KS, Djamei A, Schaffner I, Abel S, Jiang L, Mechtler K, Ikeda F, Martens S, Clausen T, Dagdas Y. Elife. 2020 Aug 27;9. pii: 58396. doi: 10.7554/eLife.58396. PubMed |
| Phosphorylation of Syntaxin-1a by casein kinase 2alpha regulates pre-synaptic vesicle exocytosis from the reserve pool. Shi VH, Craig TJ, Bishop P, Nakamura Y, Rocca D, Wilkinson KA, Henley JM. J Neurochem. 2021 Mar;156(5):614-623. doi: 10.1111/jnc.15161. Epub 2020 Sep 6. PubMed |
| KIAA1522 potentiates TNFalpha-NFkappaB signaling to antagonize platinum-based chemotherapy in lung adenocarcinoma. Wang B, Jing T, Jin W, Chen J, Wu C, Wang M, Liu Y. J Exp Clin Cancer Res. 2020 Aug 27;39(1):170. doi: 10.1186/s13046-020-01684-x. PubMed |
| Human immune disorder associated with homozygous hypomorphic mutation affecting MALT1B splice variant. Kutukculer N, Seeholzer T, O'Neill TJ, Grass C, Aykut A, Karaca NE, Durmaz A, Cogulu O, Aksu G, Gehring T, Gewies A, Krappmann D. J Allergy Clin Immunol. 2021 Feb;147(2):775-778.e8. doi: 10.1016/j.jaci.2020.07.034. Epub 2020 Aug 25. PubMed |
| Quantifying the Brain Metastatic Tumor Micro-Environment using an Organ-On-A Chip 3D Model, Machine Learning, and Confocal Tomography. Oliver CR, Westerhof TM, Castro MG, Merajver SD. J Vis Exp. 2020 Aug 16;(162). doi: 10.3791/61654. PubMed |
| A drug screening toolkit based on the -1 ribosomal frameshifting of SARS-CoV-2. Chen Y, Tao H, Shen S, Miao Z, Li L, Jia Y, Zhang H, Bai X, Fu X. Heliyon. 2020 Aug;6(8):e04793. doi: 10.1016/j.heliyon.2020.e04793. Epub 2020 Aug 26. PubMed |
| Mechanisms of autoregulation of C3G, activator of the GTPase Rap1, and its catalytic deregulation in lymphomas. Carabias A, Gomez-Hernandez M, de Cima S, Rodriguez-Blazquez A, Moran-Vaquero A, Gonzalez-Saenz P, Guerrero C, de Pereda JM. Sci Signal. 2020 Sep 1;13(647):eabb7075. doi: 10.1126/scisignal.abb7075. PubMed |
| miR-183/96/182 cluster is an important morphogenetic factor targeting PAX6 expression in differentiating human retinal organoids. Peskova L, Jurcikova D, Vanova T, Krivanek J, Capandova M, Sramkova Z, Sebestikova J, Kolouskova M, Kotasova H, Streit L, Barta T. Stem Cells. 2020 Sep 1. doi: 10.1002/stem.3272. PubMed |
| Complex roles of the actin-binding protein Girdin/GIV in DNA damage-induced apoptosis of cancer cells. Chen C, Enomoto A, Weng L, Taki T, Shiraki Y, Mii S, Ichihara R, Kanda M, Koike M, Kodera Y, Takahashi M. Cancer Sci. 2020 Nov;111(11):4303-4317. doi: 10.1111/cas.14637. Epub 2020 Sep 19. PubMed |
| An Excitable Ras/PI3K/ERK Signaling Network Controls Migration and Oncogenic Transformation in Epithelial Cells. Zhan H, Bhattacharya S, Cai H, Iglesias PA, Huang CH, Devreotes PN. Dev Cell. 2020 Sep 14;54(5):608-623.e5. doi: 10.1016/j.devcel.2020.08.001. Epub 2020 Sep 1. PubMed |
| Discovery of a Novel Chemical Scaffold Against Mutant Isocitrate Dehydrogenase 1 (IDH1). Kang CH, Choi SU, Son YH, Lee HK, Jeong HG, Yun CS, Ahn S, Park CH. Anticancer Res. 2020 Sep;40(9):4929-4935. doi: 10.21873/anticanres.14496. PubMed |
| Mechanics of a multilayer epithelium instruct tumour architecture and function. Fiore VF, Krajnc M, Quiroz FG, Levorse J, Pasolli HA, Shvartsman SY, Fuchs E. Nature. 2020 Sep;585(7825):433-439. doi: 10.1038/s41586-020-2695-9. Epub 2020 Sep 2. PubMed |
| Repurposing of KLF5 activates a cell cycle signature during the progression from a precursor state to oesophageal adenocarcinoma. Rogerson C, Ogden S, Britton E, Ang Y, Sharrocks AD. Elife. 2020 Sep 3;9:e57189. doi: 10.7554/eLife.57189. PubMed |
| Establishment and transcriptomic features of an immortalized hepatic cell line of the Chinese tree shrew. Zhang X, Yu D, Wu Y, Gu T, Ma N, Dong S, Yao YG. Appl Microbiol Biotechnol. 2020 Oct;104(20):8813-8823. doi: 10.1007/s00253-020-10855-x. Epub 2020 Sep 3. PubMed |
Background-suppressed live visualization of genomic loci with an improved CRISPR system based on a split fluorophore.
Chaudhary N, Nho SH, Cho H, Gantumur N, Ra JS, Myung K, Kim H.
Genome Res. 2020 Sep;30(9):1306-1316. doi: 10.1101/gr.260018.119. Epub 2020 Sep 4.
PubMed
Associated Plasmids |
An alpaca nanobody neutralizes SARS-CoV-2 by blocking receptor interaction.
Hanke L, Vidakovics Perez L, Sheward DJ, Das H, Schulte T, Moliner-Morro A, Corcoran M, Achour A, Karlsson Hedestam GB, Hallberg BM, Murrell B, McInerney GM.
Nat Commun. 2020 Sep 4;11(1):4420. doi: 10.1038/s41467-020-18174-5.
PubMed
Associated Plasmids |
| Endogenous retroviruses drive species-specific germline transcriptomes in mammals. Sakashita A, Maezawa S, Takahashi K, Alavattam KG, Yukawa M, Hu YC, Kojima S, Parrish NF, Barski A, Pavlicev M, Namekawa SH. Nat Struct Mol Biol. 2020 Oct;27(10):967-977. doi: 10.1038/s41594-020-0487-4. Epub 2020 Sep 7. PubMed |
| Effects of IGF-1 on Proliferation, Angiogenesis, Tumor Stem Cell Populations and Activation of AKT and Hedgehog Pathways in Oral Squamous Cell Carcinoma. Ferreira Mendes JM, de Faro Valverde L, Torres Andion Vidal M, Paredes BD, Coelho P, Allahdadi KJ, Coletta RD, Souza BSF, Rocha CAG. Int J Mol Sci. 2020 Sep 5;21(18). pii: ijms21186487. doi: 10.3390/ijms21186487. PubMed |
| YAP-Mediated Repression of HRK Regulates Tumor Growth, Therapy Response, and Survival Under Tumor Environmental Stress in Neuroblastoma. Shim J, Lee JY, Jonus HC, Arnold A, Schnepp RW, Janssen KM, Maximov V, Goldsmith KC. Cancer Res. 2020 Nov 1;80(21):4741-4753. doi: 10.1158/0008-5472.CAN-20-0025. Epub 2020 Sep 8. PubMed |
A molecular sensor to quantify the localization of proteins, DNA and nanoparticles in cells.
FitzGerald LI, Aurelio L, Chen M, Yuen D, Rennick JJ, Graham B, Johnston APR.
Nat Commun. 2020 Sep 8;11(1):4482. doi: 10.1038/s41467-020-18082-8.
PubMed
Associated Plasmids |
| CCAAT/Enhancer-Binding Protein Delta (C/EBPdelta): A Previously Unrecognized Tumor Suppressor that Limits the Oncogenic Potential of Pancreatic Ductal Adenocarcinoma Cells. Hartl L, Duitman J, Aberson HL, Chen K, Dijk F, Roelofs JJTH, Dings MPG, Hooijer GKJ, Hernanda PY, Pan Q, Busch OR, Besselink MGH, Boerman T, Peppelenbosch MP, Bijlsma MF, Spek CA. Cancers (Basel). 2020 Sep 7;12(9). pii: cancers12092546. doi: 10.3390/cancers12092546. PubMed |
| In Vivo Reporter Assays Uncover Changes in Enhancer Activity Caused by Type 2 Diabetes-Associated Single Nucleotide Polymorphisms. Eufrasio A, Perrod C, Ferreira FJ, Duque M, Galhardo M, Bessa J. Diabetes. 2020 Dec;69(12):2794-2805. doi: 10.2337/db19-1049. Epub 2020 Sep 10. PubMed |
| Molecular characterization of HLA class II binding to the LAG-3 T cell co-inhibitory receptor. MacLachlan BJ, Mason GH, Greenshields-Watson A, Triebel F, Gallimore A, Cole DK, Godkin A. Eur J Immunol. 2021 Feb;51(2):331-341. doi: 10.1002/eji.202048753. Epub 2020 Oct 9. PubMed |
| Generation of Inducible CRISPRi and CRISPRa Human Stromal/Stem Cell Lines for Controlled Target Gene Transcription during Lineage Differentiation. Chen L, Shi K, Qiu W, Aagaard L, Kassem M. Stem Cells Int. 2020 Aug 19;2020:8857344. doi: 10.1155/2020/8857344. eCollection 2020. PubMed |
| Leukemia Inhibitory Factor (LIF) Overexpression Increases the Angiogenic Potential of Bone Marrow Mesenchymal Stem/Stromal Cells. Santos GC, Silva DN, Fortuna V, Silveira BM, Orge ID, de Santana TA, Sampaio GL, Paredes BD, Ribeiro-Dos-Santos R, Soares MBP. Front Cell Dev Biol. 2020 Aug 14;8:778. doi: 10.3389/fcell.2020.00778. eCollection 2020. PubMed |
| Primate-restricted KRAB zinc finger proteins and target retrotransposons control gene expression in human neurons. Turelli P, Playfoot C, Grun D, Raclot C, Pontis J, Coudray A, Thorball C, Duc J, Pankevich EV, Deplancke B, Busskamp V, Trono D. Sci Adv. 2020 Aug 28;6(35):eaba3200. doi: 10.1126/sciadv.aba3200. eCollection 2020 Aug. PubMed |
| Protective role of histone deacetylase 4 from ultraviolet radiation-induced DNA lesions. Li S, Zhou M, Ze K, Sun X, Zhao C, Li Z, Lu H, Jiao Y, Wang T, Li S, Hua L, Cai H, Li X. Mol Carcinog. 2020 Nov;59(11):1292-1301. doi: 10.1002/mc.23257. Epub 2020 Sep 13. PubMed |
| Phosphoinositide-dependent Kinase-1 (PDPK1) regulates serum/glucocorticoid-regulated Kinase 3 (SGK3) for prostate cancer cell survival. Nalairndran G, Hassan Abdul Razack A, Mai CW, Fei-Lei Chung F, Chan KK, Hii LW, Lim WM, Chung I, Leong CO. J Cell Mol Med. 2020 Oct;24(20):12188-12198. doi: 10.1111/jcmm.15876. Epub 2020 Sep 14. PubMed |
| LncRNA DSCAM-AS1 interacts with YBX1 to promote cancer progression by forming a positive feedback loop that activates FOXA1 transcription network. Zhang Y, Huang YX, Wang DL, Yang B, Yan HY, Lin LH, Li Y, Chen J, Xie LM, Huang YS, Liao JY, Hu KS, He JH, Saw PE, Xu X, Yin D. Theranostics. 2020 Aug 29;10(23):10823-10837. doi: 10.7150/thno.47830. eCollection 2020. PubMed |
| Mutational resilience of antiviral restriction favors primate TRIM5alpha in host-virus evolutionary arms races. Tenthorey JL, Young C, Sodeinde A, Emerman M, Malik HS. Elife. 2020 Sep 15;9. pii: 59988. doi: 10.7554/eLife.59988. PubMed |
| Altered Secretome and ROS Production in Olfactory Mucosa Stem Cells Derived from Friedreich's Ataxia Patients. Perez-Luz S, Loria F, Katsu-Jimenez Y, Oberdoerfer D, Yang OL, Lim F, Munoz-Blanco JL, Diaz-Nido J. Int J Mol Sci. 2020 Sep 11;21(18). pii: ijms21186662. doi: 10.3390/ijms21186662. PubMed |
| Integration of Multiple Platforms for the Analysis of Multifluorescent Marking Technology Applied to Pediatric GBM and DIPG. Pericoli G, Petrini S, Giorda E, Ferretti R, Ajmone-Cat MA, Court W, Conti LA, De Simone R, Bencivenga P, Palma A, Di Giannatale A, Jones C, Carai A, Mastronuzzi A, de Billy E, Locatelli F, Vinci M. Int J Mol Sci. 2020 Sep 15;21(18). pii: ijms21186763. doi: 10.3390/ijms21186763. PubMed |
HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation.
Magupalli VG, Negro R, Tian Y, Hauenstein AV, Di Caprio G, Skillern W, Deng Q, Orning P, Alam HB, Maliga Z, Sharif H, Hu JJ, Evavold CL, Kagan JC, Schmidt FI, Fitzgerald KA, Kirchhausen T, Li Y, Wu H.
Science. 2020 Sep 18;369(6510). pii: 369/6510/eaas8995. doi: 10.1126/science.aas8995.
PubMed
Associated Plasmids |
| mTOR-mediated cancer drug resistance suppresses autophagy and generates a druggable metabolic vulnerability. Gremke N, Polo P, Dort A, Schneikert J, Elmshauser S, Brehm C, Klingmuller U, Schmitt A, Reinhardt HC, Timofeev O, Wanzel M, Stiewe T. Nat Commun. 2020 Sep 17;11(1):4684. doi: 10.1038/s41467-020-18504-7. PubMed |
| Genome-Scale CRISPR Screening for Regulators of Cell Fate Transitions. Carlini V, Gretarsson KH, Hackett JA. Methods Mol Biol. 2021;2214:91-108. doi: 10.1007/978-1-0716-0958-3_7. PubMed |
| Cholesterol 25-Hydroxylase inhibits SARS-CoV-2 and other coronaviruses by depleting membrane cholesterol. Wang S, Li W, Hui H, Tiwari SK, Zhang Q, Croker BA, Rawlings S, Smith D, Carlin AF, Rana TM. EMBO J. 2020 Nov 2;39(21):e106057. doi: 10.15252/embj.2020106057. Epub 2020 Oct 5. PubMed |
| The mechanistic role of alpha-synuclein in the nucleus: impaired nuclear function caused by familial Parkinson's disease SNCA mutations. Chen V, Moncalvo M, Tringali D, Tagliafierro L, Shriskanda A, Ilich E, Dong W, Kantor B, Chiba-Falek O. Hum Mol Genet. 2020 Nov 4;29(18):3107-3121. doi: 10.1093/hmg/ddaa183. PubMed |
| Telomere dysfunction activates YAP1 to drive tissue inflammation. Chakravarti D, Hu B, Mao X, Rashid A, Li J, Li J, Liao WT, Whitley EM, Dey P, Hou P, LaBella KA, Chang A, Wang G, Spring DJ, Deng P, Zhao D, Liang X, Lan Z, Lin Y, Sarkar S, Terranova C, Deribe YL, Blutt SE, Okhuysen P, Zhang J, Vilar E, Nielsen OH, Dupont A, Younes M, Patel KR, Shroyer NF, Rai K, Estes MK, Wang YA, Bertuch AA, DePinho RA. Nat Commun. 2020 Sep 21;11(1):4766. doi: 10.1038/s41467-020-18420-w. PubMed |
| Generation of Combinatorial Lentiviral Vectors Expressing Multiple Anti-Hepatitis C Virus shRNAs and Their Validation on a Novel HCV Replicon Double Reporter Cell Line. Elbadawy HM, Mohammed Abdul MI, Aljuhani N, Vitiello A, Ciccarese F, Shaker MA, Eltahir HM, Palu G, Di Antonio V, Ghassabian H, Del Vecchio C, Salata C, Franchin E, Ponterio E, Bahashwan S, Thabet K, Abouzied MM, Shehata AM, Parolin C, Calistri A, Alvisi G. Viruses. 2020 Sep 18;12(9). pii: v12091044. doi: 10.3390/v12091044. PubMed |
| Pan-cancer multi-omics analysis and orthogonal experimental assessment of epigenetic driver genes. Halaburkova A, Cahais V, Novoloaca A, Araujo MGDS, Khoueiry R, Ghantous A, Herceg Z. Genome Res. 2020 Oct;30(10):1517-1532. doi: 10.1101/gr.268292.120. Epub 2020 Sep 22. PubMed |
| PLRP2 selectively localizes synaptic membrane proteins via acyl-chain remodeling of phospholipids. Kuge H, Miyamoto I, Yagyu KI, Honke K. J Lipid Res. 2020 Dec;61(12):1747-1763. doi: 10.1194/jlr.RA120001087. Epub 2020 Sep 22. PubMed |
| Unique cellular protrusions mediate breast cancer cell migration by tethering to osteogenic cells. Muscarella AM, Dai W, Mitchell PG, Zhang W, Wang H, Jia L, Stossi F, Mancini MA, Chiu W, Zhang XH. NPJ Breast Cancer. 2020 Sep 7;6:42. doi: 10.1038/s41523-020-00183-8. eCollection 2020. PubMed |
| SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2. Clausen TM, Sandoval DR, Spliid CB, Pihl J, Perrett HR, Painter CD, Narayanan A, Majowicz SA, Kwong EM, McVicar RN, Thacker BE, Glass CA, Yang Z, Torres JL, Golden GJ, Bartels PL, Porell RN, Garretson AF, Laubach L, Feldman J, Yin X, Pu Y, Hauser BM, Caradonna TM, Kellman BP, Martino C, Gordts PLSM, Chanda SK, Schmidt AG, Godula K, Leibel SL, Jose J, Corbett KD, Ward AB, Carlin AF, Esko JD. Cell. 2020 Nov 12;183(4):1043-1057.e15. doi: 10.1016/j.cell.2020.09.033. Epub 2020 Sep 14. PubMed |
| FGFR1 Is Critical for RBL2 Loss-Driven Tumor Development and Requires PLCG1 Activation for Continued Growth of Small Cell Lung Cancer. Kim KB, Kim Y, Rivard CJ, Kim DW, Park KS. Cancer Res. 2020 Nov 15;80(22):5051-5062. doi: 10.1158/0008-5472.CAN-20-1453. Epub 2020 Sep 24. PubMed |
| MFSD7C switches mitochondrial ATP synthesis to thermogenesis in response to heme. Li Y, Ivica NA, Dong T, Papageorgiou DP, He Y, Brown DR, Kleyman M, Hu G, Chen WW, Sullivan LB, Del Rosario A, Hammond PT, Vander Heiden MG, Chen J. Nat Commun. 2020 Sep 24;11(1):4837. doi: 10.1038/s41467-020-18607-1. PubMed |
| A new agarose-based microsystem to investigate cell response to prolonged confinement. Prunet A, Lefort S, Delanoe-Ayari H, Laperrousaz B, Simon G, Barentin C, Saci S, Argoul F, Guyot B, Rieu JP, Gobert S, Maguer-Satta V, Riviere C. Lab Chip. 2020 Nov 7;20(21):4016-4030. doi: 10.1039/d0lc00732c. Epub 2020 Sep 25. PubMed |
| Cholesterol Pathway Inhibition Induces TGF-beta Signaling to Promote Basal Differentiation in Pancreatic Cancer. Gabitova-Cornell L, Surumbayeva A, Peri S, Franco-Barraza J, Restifo D, Weitz N, Ogier C, Goldman AR, Hartman TR, Francescone R, Tan Y, Nicolas E, Shah N, Handorf EA, Cai KQ, O'Reilly AM, Sloma I, Chiaverelli R, Moffitt RA, Khazak V, Fang CY, Golemis EA, Cukierman E, Astsaturov I. Cancer Cell. 2020 Oct 12;38(4):567-583.e11. doi: 10.1016/j.ccell.2020.08.015. Epub 2020 Sep 24. PubMed |
| In Vitro Studies to Define the Cell-Surface and Intracellular Targets of Polyarginine-Conjugated Sodium Borocaptate as a Potential Delivery Agent for Boron Neutron Capture Therapy. Fujimura A, Yasui S, Igawa K, Ueda A, Watanabe K, Hanafusa T, Ichikawa Y, Yoshihashi S, Tsuchida K, Kamiya A, Furuya S. Cells. 2020 Sep 23;9(10). pii: cells9102149. doi: 10.3390/cells9102149. PubMed |
| Plasmodium berghei sporozoites in nonreplicative vacuole are eliminated by a PI3P-mediated autophagy-independent pathway. Bindschedler A, Wacker R, Egli J, Eickel N, Schmuckli-Maurer J, Franke-Fayard BM, Janse CJ, Heussler VT. Cell Microbiol. 2021 Jan;23(1):e13271. doi: 10.1111/cmi.13271. Epub 2020 Oct 8. PubMed |
| RPS5 interacts with the rabbit hemorrhagic disease virus 3' extremities region and plays a role in virus replication. Guo H, Zhu J, Miao Q, Qi R, Tang A, Liu C, Yang H, Yuan L, Liu G. Vet Microbiol. 2020 Oct;249:108858. doi: 10.1016/j.vetmic.2020.108858. Epub 2020 Sep 18. PubMed |
| Optimized Transgene Delivery Using Third-Generation Lentiviruses. Gill KP, Denham M. Curr Protoc Mol Biol. 2020 Dec;133(1):e125. doi: 10.1002/cpmb.125. PubMed |
| NFIA differentially controls adipogenic and myogenic gene program through distinct pathways to ensure brown and beige adipocyte differentiation. Hiraike Y, Waki H, Miyake K, Wada T, Oguchi M, Saito K, Tsutsumi S, Aburatani H, Yamauchi T, Kadowaki T. PLoS Genet. 2020 Sep 29;16(9):e1009044. doi: 10.1371/journal.pgen.1009044. eCollection 2020 Sep. PubMed |
| Protocol for Designing Small-Molecule-Regulated Destabilizing Domains for In Vitro Use. Ramadurgum P, Hulleman JD. STAR Protoc. 2020 Sep 18;1(2). doi: 10.1016/j.xpro.2020.100069. Epub 2020 Jul 24. PubMed |
| Co-culture Systems of Drug-Treated Acute Myeloid Leukemia Cells and T Cells for In Vitro and In Vivo Study. Li Y, Su R, Chen J. STAR Protoc. 2020 Sep 18;1(2). doi: 10.1016/j.xpro.2020.100097. Epub 2020 Aug 28. PubMed |
| MYC Promotes Bone Marrow Stem Cell Dysfunction in Fanconi Anemia. Rodriguez A, Zhang K, Farkkila A, Filiatrault J, Yang C, Velazquez M, Furutani E, Goldman DC, Garcia de Teresa B, Garza-Mayen G, McQueen K, Sambel LA, Molina B, Torres L, Gonzalez M, Vadillo E, Pelayo R, Fleming WH, Grompe M, Shimamura A, Hautaniemi S, Greenberger J, Frias S, Parmar K, D'Andrea AD. Cell Stem Cell. 2021 Jan 7;28(1):33-47.e8. doi: 10.1016/j.stem.2020.09.004. Epub 2020 Sep 29. PubMed |
| Thermofluidic heat exchangers for actuation of transcription in artificial tissues. Corbett DC, Fabyan WB, Grigoryan B, O'Connor CE, Johansson F, Batalov I, Regier MC, DeForest CA, Miller JS, Stevens KR. Sci Adv. 2020 Sep 30;6(40). pii: 6/40/eabb9062. doi: 10.1126/sciadv.abb9062. Print 2020 Sep. PubMed |
| Identification of Cx45 as a Major Component of GJs in HeLa Cells. Choi EJ, Palacios-Prado N, Saez JC, Lee J. Biomolecules. 2020 Sep 29;10(10). pii: biom10101389. doi: 10.3390/biom10101389. PubMed |
| Orally bioavailable CDK9/2 inhibitor shows mechanism-based therapeutic potential in MYCN-driven neuroblastoma. Poon E, Liang T, Jamin Y, Walz S, Kwok C, Hakkert A, Barker K, Urban Z, Thway K, Zeid R, Hallsworth A, Box G, Ebus ME, Licciardello MP, Sbirkov Y, Lazaro G, Calton E, Costa BM, Valenti M, De Haven Brandon A, Webber H, Tardif N, Almeida GS, Christova R, Boysen G, Richards MW, Barone G, Ford A, Bayliss R, Clarke PA, De Bono J, Gray NS, Blagg J, Robinson SP, Eccles SA, Zheleva D, Bradner JE, Molenaar J, Vivanco I, Eilers M, Workman P, Lin CY, Chesler L. J Clin Invest. 2020 Nov 2;130(11):5875-5892. doi: 10.1172/JCI134132. PubMed |
| Protein Disulphide Isomerase A1 Is Involved in the Regulation of Breast Cancer Cell Adhesion and Transmigration via Lung Microvascular Endothelial Cells. Stojak M, Milczarek M, Kurpinska A, Suraj-Prazmowska J, Kaczara P, Wojnar-Lason K, Banach J, Stachowicz-Suhs M, Rossowska J, Kalvins I, Wietrzyk J, Chlopicki S. Cancers (Basel). 2020 Oct 2;12(10). pii: cancers12102850. doi: 10.3390/cancers12102850. PubMed |
| A system-level approach identifies HIF-2alpha as a critical regulator of chondrosarcoma progression. Kim H, Cho Y, Kim HS, Kang D, Cheon D, Kim YJ, Chang MJ, Lee KM, Chang CB, Kang SB, Kang HG, Kim JH. Nat Commun. 2020 Oct 6;11(1):5023. doi: 10.1038/s41467-020-18817-7. PubMed |
| Collagen-rich omentum is a premetastatic niche for integrin alpha2-mediated peritoneal metastasis. Huang YL, Liang CY, Ritz D, Coelho R, Septiadi D, Estermann M, Cumin C, Rimmer N, Schotzau A, Nunez Lopez M, Fedier A, Konantz M, Vlajnic T, Calabrese D, Lengerke C, David L, Rothen-Rutishauser B, Jacob F, Heinzelmann-Schwarz V. Elife. 2020 Oct 7;9. pii: 59442. doi: 10.7554/eLife.59442. PubMed |
| MED19 Regulates Adipogenesis and Maintenance of White Adipose Tissue Mass by Mediating PPARgamma-Dependent Gene Expression. Dean JM, He A, Tan M, Wang J, Lu D, Razani B, Lodhi IJ. Cell Rep. 2020 Oct 6;33(1):108228. doi: 10.1016/j.celrep.2020.108228. PubMed |
| Respiratory Supercomplexes Promote Mitochondrial Efficiency and Growth in Severely Hypoxic Pancreatic Cancer. Hollinshead KER, Parker SJ, Eapen VV, Encarnacion-Rosado J, Sohn A, Oncu T, Cammer M, Mancias JD, Kimmelman AC. Cell Rep. 2020 Oct 6;33(1):108231. doi: 10.1016/j.celrep.2020.108231. PubMed |
| In vivo CRISPR/Cas9 targeting of fusion oncogenes for selective elimination of cancer cells. Martinez-Lage M, Torres-Ruiz R, Puig-Serra P, Moreno-Gaona P, Martin MC, Moya FJ, Quintana-Bustamante O, Garcia-Silva S, Carcaboso AM, Petazzi P, Bueno C, Mora J, Peinado H, Segovia JC, Menendez P, Rodriguez-Perales S. Nat Commun. 2020 Oct 8;11(1):5060. doi: 10.1038/s41467-020-18875-x. PubMed |
| Identification of a dynamic gene regulatory network required for pluripotency factor-induced reprogramming of mouse fibroblasts and hepatocytes. Papathanasiou M, Tsiftsoglou SA, Polyzos AP, Papadopoulou D, Valakos D, Klagkou E, Karagianni P, Pliatska M, Talianidis I, Agelopoulos M, Thanos D. EMBO J. 2021 Jan 4;40(1):e102236. doi: 10.15252/embj.2019102236. Epub 2020 Oct 9. PubMed |
| Efficacy of the novel tubulin polymerization inhibitor PTC-028 for myelodysplastic syndrome. Zhong C, Kayamori K, Koide S, Shinoda D, Oshima M, Nakajima-Takagi Y, Nagai Y, Mimura N, Sakaida E, Yamazaki S, Iwano S, Miyawaki A, Ito R, Tohyama K, Yamaguchi K, Furukawa Y, Lennox W, Sheedy J, Weetall M, Iwama A. Cancer Sci. 2020 Dec;111(12):4336-4347. doi: 10.1111/cas.14684. Epub 2020 Nov 2. PubMed |
| MLLT6 maintains PD-L1 expression and mediates tumor immune resistance. Sreevalsan S, Doring M, Paszkowski-Rogacz M, Brux M, Blanck C, Meyer M, Momburg F, Buchholz F, Theis M. EMBO Rep. 2020 Dec 3;21(12):e50155. doi: 10.15252/embr.202050155. Epub 2020 Oct 15. PubMed |
| Conditional guide RNA through two intermediate hairpins for programmable CRISPR/Cas9 function: building regulatory connections between endogenous RNA expressions. Lin J, Liu Y, Lai P, Ye H, Xu L. Nucleic Acids Res. 2020 Nov 18;48(20):11773-11784. doi: 10.1093/nar/gkaa842. PubMed |
| Generation of a cost-effective cell line for support of high-throughput isolation of primary human B cells and monoclonal neutralizing antibodies. Whaley RE, Ameny S, Arkatkar T, Seese A, Wall A, Khan I, Carter JJ, Scherer EM, Rawlings DJ, Galloway DA, McElrath MJ, Cohen KW, McGuire AT. J Immunol Methods. 2021 Jan;488:112901. doi: 10.1016/j.jim.2020.112901. Epub 2020 Oct 15. PubMed |
| Functional role of the long noncoding RNA X-inactive specific transcript in leiomyoma pathogenesis. Chuang TD, Rehan A, Khorram O. Fertil Steril. 2021 Jan;115(1):238-247. doi: 10.1016/j.fertnstert.2020.07.024. Epub 2020 Oct 15. PubMed |
| The Human-Specific STING Agonist G10 Activates Type I Interferon and the NLRP3 Inflammasome in Porcine Cells. Ming SL, Zeng L, Guo YK, Zhang S, Li GL, Ma YX, Zhai YY, Chang WR, Yang L, Wang J, Yang GY, Chu BB. Front Immunol. 2020 Sep 24;11:575818. doi: 10.3389/fimmu.2020.575818. eCollection 2020. PubMed |
| Contribution of GATA6 to homeostasis of the human upper pilosebaceous unit and acne pathogenesis. Oules B, Philippeos C, Segal J, Tihy M, Vietri Rudan M, Cujba AM, Grange PA, Quist S, Natsuga K, Deschamps L, Dupin N, Donati G, Watt FM. Nat Commun. 2020 Oct 20;11(1):5067. doi: 10.1038/s41467-020-18784-z. PubMed |
| Enhancer Reprogramming Confers Dependence on Glycolysis and IGF Signaling in KMT2D Mutant Melanoma. Maitituoheti M, Keung EZ, Tang M, Yan L, Alam H, Han G, Singh AK, Raman AT, Terranova C, Sarkar S, Orouji E, Amin SB, Sharma S, Williams M, Samant NS, Dhamdhere M, Zheng N, Shah T, Shah A, Axelrad JB, Anvar NE, Lin YH, Jiang S, Chang EQ, Ingram DR, Wang WL, Lazar A, Lee MG, Muller F, Wang L, Ying H, Rai K. Cell Rep. 2020 Oct 20;33(3):108293. doi: 10.1016/j.celrep.2020.108293. PubMed |
| PLA2G6 guards placental trophoblasts against ferroptotic injury. Beharier O, Tyurin VA, Goff JP, Guerrero-Santoro J, Kajiwara K, Chu T, Tyurina YY, St Croix CM, Wallace CT, Parry S, Parks WT, Kagan VE, Sadovsky Y. Proc Natl Acad Sci U S A. 2020 Nov 3;117(44):27319-27328. doi: 10.1073/pnas.2009201117. Epub 2020 Oct 21. PubMed |
| SPATA33 is an autophagy mediator for cargo selectivity in germline mitophagy. Zhang Y, Xu X, Hu M, Wang X, Cheng H, Zhou R. Cell Death Differ. 2021 Mar;28(3):1076-1090. doi: 10.1038/s41418-020-00638-2. Epub 2020 Oct 21. PubMed |
| XBP1 increases transactivation of somatic mutants of ESR1 and loss of XBP1 reverses endocrine resistance conferred by gain-of-function Y537S ESR1 mutation. Barua D, Abbasi B, Gupta A, Gupta S. Heliyon. 2020 Oct 10;6(10):e05217. doi: 10.1016/j.heliyon.2020.e05217. eCollection 2020 Oct. PubMed |
| Phosphoinositide 3'-Kinase gamma Facilitates Polyomavirus Infection. Clark P, Gee GV, Albright BS, Assetta B, Han Y, Atwood WJ, DiMaio D. Viruses. 2020 Oct 20;12(10). pii: v12101190. doi: 10.3390/v12101190. PubMed |
Metabolic plasticity of IDH1-mutant glioma cell lines is responsible for low sensitivity to glutaminase inhibition.
Ruiz-Rodado V, Lita A, Dowdy T, Celiku O, Saldana AC, Wang H, Yang CZ, Chari R, Li A, Zhang W, Song H, Zhang M, Ahn S, Davis D, Chen X, Zhuang Z, Herold-Mende C, Walters KJ, Gilbert MR, Larion M.
Cancer Metab. 2020 Oct 21;8:23. doi: 10.1186/s40170-020-00229-2. eCollection 2020.
PubMed
Associated Plasmids |
| SHOC2 Is a Critical Modulator of Sensitivity to EGFR-TKIs in Non-Small Cell Lung Cancer Cells. Terai H, Hamamoto J, Emoto K, Masuda T, Manabe T, Kuronuma S, Kobayashi K, Masuzawa K, Ikemura S, Nakayama S, Kawada I, Suzuki Y, Takeuchi O, Suzuki Y, Ohtsuki S, Yasuda H, Soejima K, Fukunaga K. Mol Cancer Res. 2021 Feb;19(2):317-328. doi: 10.1158/1541-7786.MCR-20-0664. Epub 2020 Oct 26. PubMed |
| ABRO1 stabilizes the deubiquitinase BRCC3 through inhibiting its degradation mediated by the E3 ubiquitin ligase WWP2. Zhang W, Tao SS, Wang T, Zhang J, Liu X, Li YT, Chen H, Zhan YQ, Yu M, Ge CH, Li CY, Ren GM, Yang XM, Yin RH. FEBS Lett. 2021 Jan;595(2):169-182. doi: 10.1002/1873-3468.13970. Epub 2020 Nov 8. PubMed |
| Activation of Clustered IFNgamma Target Genes Drives Cohesin-Controlled Transcriptional Memory. Siwek W, Tehrani SSH, Mata JF, Jansen LET. Mol Cell. 2020 Nov 5;80(3):396-409.e6. doi: 10.1016/j.molcel.2020.10.005. Epub 2020 Oct 26. PubMed |
| ATF4 links ER stress with reticulophagy in glioblastoma cells. Zielke S, Kardo S, Zein L, Mari M, Covarrubias-Pinto A, Kinzler MN, Meyer N, Stolz A, Fulda S, Reggiori F, Kogel D, van Wijk S. Autophagy. 2021 Sep;17(9):2432-2448. doi: 10.1080/15548627.2020.1827780. Epub 2020 Oct 28. PubMed |
| SARS-CoV-2 Infects the Brain Choroid Plexus and Disrupts the Blood-CSF Barrier in Human Brain Organoids. Pellegrini L, Albecka A, Mallery DL, Kellner MJ, Paul D, Carter AP, James LC, Lancaster MA. Cell Stem Cell. 2020 Dec 3;27(6):951-961.e5. doi: 10.1016/j.stem.2020.10.001. Epub 2020 Oct 13. PubMed |
| Orthogonal SARS-CoV-2 Serological Assays Enable Surveillance of Low-Prevalence Communities and Reveal Durable Humoral Immunity. Ripperger TJ, Uhrlaub JL, Watanabe M, Wong R, Castaneda Y, Pizzato HA, Thompson MR, Bradshaw C, Weinkauf CC, Bime C, Erickson HL, Knox K, Bixby B, Parthasarathy S, Chaudhary S, Natt B, Cristan E, El Aini T, Rischard F, Campion J, Chopra M, Insel M, Sam A, Knepler JL, Capaldi AP, Spier CM, Dake MD, Edwards T, Kaplan ME, Scott SJ, Hypes C, Mosier J, Harris DT, LaFleur BJ, Sprissler R, Nikolich-Zugich J, Bhattacharya D. Immunity. 2020 Nov 17;53(5):925-933.e4. doi: 10.1016/j.immuni.2020.10.004. Epub 2020 Oct 14. PubMed |
| Circular RNA circTP63 enhances estrogen receptor-positive breast cancer progression and malignant behaviors through the miR-873-3p/FOXM1 axis. Deng Y, Xia J, Xu YE. Anticancer Drugs. 2021 Jan 1;32(1):44-52. doi: 10.1097/CAD.0000000000001010. PubMed |
| Broad genic repression domains signify enhanced silencing of oncogenes. Zhao D, Zhang L, Zhang M, Xia B, Lv J, Gao X, Wang G, Meng Q, Yi Y, Zhu S, Tomoiaga AS, Lee MG, Cooke JP, Cao Q, Chen K. Nat Commun. 2020 Nov 3;11(1):5560. doi: 10.1038/s41467-020-18913-8. PubMed |
Identification of Required Host Factors for SARS-CoV-2 Infection in Human Cells.
Daniloski Z, Jordan TX, Wessels HH, Hoagland DA, Kasela S, Legut M, Maniatis S, Mimitou EP, Lu L, Geller E, Danziger O, Rosenberg BR, Phatnani H, Smibert P, Lappalainen T, tenOever BR, Sanjana NE.
Cell. 2020 Oct 24. pii: S0092-8674(20)31394-5. doi: 10.1016/j.cell.2020.10.030.
PubMed
Associated Plasmids |
ZNF354C is a transcriptional repressor that inhibits endothelial angiogenic sprouting.
Oo JA, Irmer B, Gunther S, Warwick T, Palfi K, Izquierdo Ponce J, Teichmann T, Pfluger-Muller B, Gilsbach R, Brandes RP, Leisegang MS.
Sci Rep. 2020 Nov 5;10(1):19079. doi: 10.1038/s41598-020-76193-0.
PubMed
Associated Plasmids |
| Proteasome-Bound UCH37/UCHL5 Debranches Ubiquitin Chains to Promote Degradation. Deol KK, Crowe SO, Du J, Bisbee HA, Guenette RG, Strieter ER. Mol Cell. 2020 Dec 3;80(5):796-809.e9. doi: 10.1016/j.molcel.2020.10.017. Epub 2020 Nov 5. PubMed |
| Genetically Defined Syngeneic Mouse Models of Ovarian Cancer as Tools for the Discovery of Combination Immunotherapy. Iyer S, Zhang S, Yucel S, Horn H, Smith SG, Reinhardt F, Hoefsmit E, Assatova B, Casado J, Meinsohn MC, Barrasa MI, Bell GW, Perez-Villatoro F, Huhtinen K, Hynninen J, Oikkonen J, Galhenage PM, Pathania S, Hammond PT, Neel BG, Farkkila A, Pepin D, Weinberg RA. Cancer Discov. 2021 Feb;11(2):384-407. doi: 10.1158/2159-8290.CD-20-0818. Epub 2020 Nov 6. PubMed |
| CRISPR-Cas9-mediated knockout of GCN2 reveals a critical role in sensing amino acid deprivation in bovine mammary epithelial cells. Edick AM, Audette J, Burgos SA. J Dairy Sci. 2021 Jan;104(1):1123-1135. doi: 10.3168/jds.2020-18700. Epub 2020 Nov 6. PubMed |
| CEBPG promotes esophageal squamous cell carcinoma progression by enhancing PI3K-AKT signaling. Huang Y, Lin L, Shen Z, Li Y, Cao H, Peng L, Qiu Y, Cheng X, Meng M, Lu D, Yin D. Am J Cancer Res. 2020 Oct 1;10(10):3328-3344. eCollection 2020. PubMed |
| Role of Tissue Transglutaminase Catalytic and Guanosine Triphosphate-Binding Domains in Renal Cell Carcinoma Progression. Ulukan B, Bihorac A, Sipahioglu T, Kiraly R, Fesus L, Telci D. ACS Omega. 2020 Oct 20;5(43):28273-28284. doi: 10.1021/acsomega.0c04226. eCollection 2020 Nov 3. PubMed |
| Characterizing the In Vivo Role of Candidate Leukemia Stem Cell Genes. Zhang YW, Mess J, Cabezas-Wallscheid N. Methods Mol Biol. 2021;2185:307-316. doi: 10.1007/978-1-0716-0810-4_19. PubMed |
| Regulation of PD-L1 expression in K-ras-driven cancers through ROS-mediated FGFR1 signaling. Glorieux C, Xia X, He YQ, Hu Y, Cremer K, Robert A, Liu J, Wang F, Ling J, Chiao PJ, Huang P. Redox Biol. 2021 Jan;38:101780. doi: 10.1016/j.redox.2020.101780. Epub 2020 Nov 3. PubMed |
| ESRRA (estrogen related receptor alpha) is a critical regulator of intestinal homeostasis through activation of autophagic flux via gut microbiota. Kim S, Lee JY, Shin SG, Kim JK, Silwal P, Kim YJ, Shin NR, Kim PS, Won M, Lee SH, Kim SY, Sasai M, Yamamoto M, Kim JM, Bae JW, Jo EK. Autophagy. 2021 Oct;17(10):2856-2875. doi: 10.1080/15548627.2020.1847460. Epub 2020 Dec 15. PubMed |
| An endoribonuclease-based feedforward controller for decoupling resource-limited genetic modules in mammalian cells. Jones RD, Qian Y, Siciliano V, DiAndreth B, Huh J, Weiss R, Del Vecchio D. Nat Commun. 2020 Nov 10;11(1):5690. doi: 10.1038/s41467-020-19126-9. PubMed |
| Decoding myofibroblast origins in human kidney fibrosis. Kuppe C, Ibrahim MM, Kranz J, Zhang X, Ziegler S, Perales-Paton J, Jansen J, Reimer KC, Smith JR, Dobie R, Wilson-Kanamori JR, Halder M, Xu Y, Kabgani N, Kaesler N, Klaus M, Gernhold L, Puelles VG, Huber TB, Boor P, Menzel S, Hoogenboezem RM, Bindels EMJ, Steffens J, Floege J, Schneider RK, Saez-Rodriguez J, Henderson NC, Kramann R. Nature. 2021 Jan;589(7841):281-286. doi: 10.1038/s41586-020-2941-1. Epub 2020 Nov 11. PubMed |
| Human Cytomegalovirus Interactions with the Basement Membrane Protein Nidogen 1. Kuan MI, Jaeger HK, Balemba OB, O'Dowd JM, Duricka D, Hannemann H, Marx E, Teissier N, Gabrielli L, Bonasoni MP, Keithley EM, Fortunato EA. J Virol. 2021 Jan 13;95(3). pii: JVI.01506-20. doi: 10.1128/JVI.01506-20. Print 2021 Jan 13. PubMed |
| Role of the SIRT1/p53 regulatory axis in oxidative stressmediated granulosa cell apoptosis. Park SA, Joo NR, Park JH, Oh SM. Mol Med Rep. 2021 Jan;23(1). pii: 20. doi: 10.3892/mmr.2020.11658. Epub 2020 Nov 12. PubMed |
| A versatile oblique plane microscope for large-scale and high-resolution imaging of subcellular dynamics. Sapoznik E, Chang BJ, Huh J, Ju RJ, Azarova EV, Pohlkamp T, Welf ES, Broadbent D, Carisey AF, Stehbens SJ, Lee KM, Marin A, Hanker AB, Schmidt JC, Arteaga CL, Yang B, Kobayashi Y, Tata PR, Kruithoff R, Doubrovinski K, Shepherd DP, Millett-Sikking A, York AG, Dean KM, Fiolka RP. Elife. 2020 Nov 12;9. pii: 57681. doi: 10.7554/eLife.57681. PubMed |
| Ubiquitination and the proteasome rather than caspase-3-mediated C-terminal cleavage are involved in the EAAT2 degradation by staurosporine-induced cellular stress. Voss TD, Gerget M, Linkus B, von Einem B, Landwehrmeyer GB, Lewerenz J. J Neurochem. 2021 May;157(4):1284-1299. doi: 10.1111/jnc.15237. Epub 2020 Dec 3. PubMed |
| Engineering of alpha-PD-1 antibody-expressing long-lived plasma cells by CRISPR/Cas9-mediated targeted gene integration. Luo B, Zhan Y, Luo M, Dong H, Liu J, Lin Y, Zhang J, Wang G, Verhoeyen E, Zhang Y, Zhang H. Cell Death Dis. 2020 Nov 12;11(11):973. doi: 10.1038/s41419-020-03187-1. PubMed |
| A conserved acetylation switch enables pharmacological control of tubby-like protein stability. Kerek EM, Yoon KH, Luo SY, Chen J, Valencia R, Julien O, Waskiewicz AJ, Hubbard BP. J Biol Chem. 2021 Jan-Jun;296:100073. doi: 10.1074/jbc.RA120.015839. Epub 2020 Nov 23. PubMed |
| SLX4IP Promotes Telomere Maintenance in Androgen Receptor-Independent Castration-Resistant Prostate Cancer through ALT-like Telomeric PML Localization. Mangosh TL, Awadallah WN, Grabowska MM, Taylor DJ. Mol Cancer Res. 2021 Feb;19(2):301-316. doi: 10.1158/1541-7786.MCR-20-0314. Epub 2020 Nov 13. PubMed |
| Efferocytic Defects in Early Atherosclerosis Are Driven by GATA2 Overexpression in Macrophages. Yin C, Vrieze AM, Rosoga M, Akingbasote J, Pawlak EN, Jacob RA, Hu J, Sharma N, Dikeakos JD, Barra L, Nagpal AD, Heit B. Front Immunol. 2020 Oct 23;11:594136. doi: 10.3389/fimmu.2020.594136. eCollection 2020. PubMed |
| Loss of HCRP1 leads to upregulation of PD-L1 via STAT3 activation and is of prognostic significance in EGFR-dependent cancer. Tomasich E, Topakian T, Heller G, Udovica S, Krainer M, Marhold M. Transl Res. 2021 Apr;230:21-33. doi: 10.1016/j.trsl.2020.11.005. Epub 2020 Nov 13. PubMed |
| Mutations in GRK2 cause Jeune syndrome by impairing Hedgehog and canonical Wnt signaling. Bosakova M, Abraham SP, Nita A, Hruba E, Buchtova M, Taylor SP, Duran I, Martin J, Svozilova K, Barta T, Varecha M, Balek L, Kohoutek J, Radaszkiewicz T, Pusapati GV, Bryja V, Rush ET, Thiffault I, Nickerson DA, Bamshad MJ, Rohatgi R, Cohn DH, Krakow D, Krejci P. EMBO Mol Med. 2020 Nov 6;12(11):e11739. doi: 10.15252/emmm.201911739. Epub 2020 Oct 14. PubMed |
| Requisite Chromatin Remodeling for Myeloid and Erythroid Lineage Differentiation from Erythromyeloid Progenitors. Wu J, Krchma K, Lee HJ, Prabhakar S, Wang X, Zhao H, Xing X, Seong RH, Fremont DH, Artyomov MN, Wang T, Choi K. Cell Rep. 2020 Nov 17;33(7):108395. doi: 10.1016/j.celrep.2020.108395. PubMed |
| EZH2-mediated PP2A inactivation confers resistance to HER2-targeted breast cancer therapy. Bao Y, Oguz G, Lee WC, Lee PL, Ghosh K, Li J, Wang P, Lobie PE, Ehmsen S, Ditzel HJ, Wong A, Tan EY, Lee SC, Yu Q. Nat Commun. 2020 Nov 18;11(1):5878. doi: 10.1038/s41467-020-19704-x. PubMed |
| Calcineurin phosphatase activity regulates Varicella-Zoster Virus induced cell-cell fusion. Zhou M, Kamarshi V, Arvin AM, Oliver SL. PLoS Pathog. 2020 Nov 20;16(11):e1009022. doi: 10.1371/journal.ppat.1009022. eCollection 2020 Nov. PubMed |
| Stabilization of ERK-Phosphorylated METTL3 by USP5 Increases m(6)A Methylation. Sun HL, Zhu AC, Gao Y, Terajima H, Fei Q, Liu S, Zhang L, Zhang Z, Harada BT, He YY, Bissonnette MB, Hung MC, He C. Mol Cell. 2020 Nov 19;80(4):633-647.e7. doi: 10.1016/j.molcel.2020.10.026. PubMed |
| Phosphorylation of the RB C-terminus regulates condensin II release from chromatin. Kim SJ, MacDonald JI, Dick FA. J Biol Chem. 2021 Jan-Jun;296:100108. doi: 10.1074/jbc.RA120.016511. Epub 2020 Dec 3. PubMed |
| HTCC as a Polymeric Inhibitor of SARS-CoV-2 and MERS-CoV. Milewska A, Chi Y, Szczepanski A, Barreto-Duran E, Dabrowska A, Botwina P, Obloza M, Liu K, Liu D, Guo X, Ge Y, Li J, Cui L, Ochman M, Urlik M, Rodziewicz-Motowidlo S, Zhu F, Szczubialka K, Nowakowska M, Pyrc K. J Virol. 2021 Jan 28;95(4). pii: JVI.01622-20. doi: 10.1128/JVI.01622-20. Print 2021 Jan 28. PubMed |
| Mutations in Spliceosomal Genes PPIL1 and PRP17 Cause Neurodegenerative Pontocerebellar Hypoplasia with Microcephaly. Chai G, Webb A, Li C, Antaki D, Lee S, Breuss MW, Lang N, Stanley V, Anzenberg P, Yang X, Marshall T, Gaffney P, Wierenga KJ, Chung BH, Tsang MH, Pais LS, Lovgren AK, VanNoy GE, Rehm HL, Mirzaa G, Leon E, Diaz J, Neumann A, Kalverda AP, Manfield IW, Parry DA, Logan CV, Johnson CA, Bonthron DT, Valleley EMA, Issa MY, Abdel-Ghafar SF, Abdel-Hamid MS, Jennings P, Zaki MS, Sheridan E, Gleeson JG. Neuron. 2021 Jan 20;109(2):241-256.e9. doi: 10.1016/j.neuron.2020.10.035. Epub 2020 Nov 20. PubMed |
| Integrative analysis reveals novel driver genes and molecular subclasses of hepatocellular carcinoma. Yang L, Zhang Z, Sun Y, Pang S, Yao Q, Lin P, Cheng J, Li J, Ding G, Hui L, Li Y, Li H. Aging (Albany NY). 2020 Nov 20;12(23):23849-23871. doi: 10.18632/aging.104047. Epub 2020 Nov 20. PubMed |
| Human RNase3 immune modulation by catalytic-dependent and independent modes in a macrophage-cell line infection model. Lu L, Wei R, Prats-Ejarque G, Goetz M, Wang G, Torrent M, Boix E. Cell Mol Life Sci. 2021 Mar;78(6):2963-2985. doi: 10.1007/s00018-020-03695-5. Epub 2020 Nov 23. PubMed |
| Genome-scale CRISPR screening at high sensitivity with an empirically designed sgRNA library. Henkel L, Rauscher B, Schmitt B, Winter J, Boutros M. BMC Biol. 2020 Nov 23;18(1):174. doi: 10.1186/s12915-020-00905-1. PubMed |
| Optical quantification of intracellular mass density and cell mechanics in 3D mechanical confinement. Bakhshandeh S, Taieb HM, Schlussler R, Kim K, Beck T, Taubenberger A, Guck J, Cipitria A. Soft Matter. 2021 Jan 28;17(4):853-862. doi: 10.1039/d0sm01556c. Epub 2020 Nov 24. PubMed |
| Kallikrein 13 serves as a priming protease during infection by the human coronavirus HKU1. Milewska A, Falkowski K, Kulczycka M, Bielecka E, Naskalska A, Mak P, Lesner A, Ochman M, Urlik M, Diamandis E, Prassas I, Potempa J, Kantyka T, Pyrc K. Sci Signal. 2020 Nov 24;13(659). pii: 13/659/eaba9902. doi: 10.1126/scisignal.aba9902. PubMed |
| Cholesterol 25-hydroxylase suppresses SARS-CoV-2 replication by blocking membrane fusion. Zang R, Case JB, Yutuc E, Ma X, Shen S, Gomez Castro MF, Liu Z, Zeng Q, Zhao H, Son J, Rothlauf PW, Kreutzberger AJB, Hou G, Zhang H, Bose S, Wang X, Vahey MD, Mani K, Griffiths WJ, Kirchhausen T, Fremont DH, Guo H, Diwan A, Wang Y, Diamond MS, Whelan SPJ, Ding S. Proc Natl Acad Sci U S A. 2020 Dec 15;117(50):32105-32113. doi: 10.1073/pnas.2012197117. Epub 2020 Nov 25. PubMed |
| BCCIP is required for nucleolar recruitment of eIF6 and 12S pre-rRNA production during 60S ribosome biogenesis. Ye C, Liu B, Lu H, Liu J, Rabson AB, Jacinto E, Pestov DG, Shen Z. Nucleic Acids Res. 2020 Dec 16;48(22):12817-12832. doi: 10.1093/nar/gkaa1114. PubMed |
| Evaluating the Genomic Parameters Governing rAAV-Mediated Homologous Recombination. Spector LP, Tiffany M, Ferraro NM, Abell NS, Montgomery SB, Kay MA. Mol Ther. 2021 Mar 3;29(3):1028-1046. doi: 10.1016/j.ymthe.2020.11.025. Epub 2020 Nov 26. PubMed |
| Relative expression of KLK5 to LEKTI is associated with aggressiveness of oral squamous cell carcinoma. Alves MG, Kodama MH, da Silva EZM, Gomes BBM, da Silva RAA, Vieira GV, Alves VM, da Fonseca CK, Santana AC, Cecilio NT, Costa MSA, Jamur MC, Oliver C, Cunha TM, Bugge TH, Braz-Silva PH, Colli LM, Sales KU. Transl Oncol. 2021 Jan;14(1):100970. doi: 10.1016/j.tranon.2020.100970. Epub 2020 Nov 28. PubMed |
| A macrophage-specific lncRNA regulates apoptosis and atherosclerosis by tethering HuR in the nucleus. Simion V, Zhou H, Haemmig S, Pierce JB, Mendes S, Tesmenitsky Y, Perez-Cremades D, Lee JF, Chen AF, Ronda N, Papotti B, Marto JA, Feinberg MW. Nat Commun. 2020 Dec 1;11(1):6135. doi: 10.1038/s41467-020-19664-2. PubMed |
| Master Regulators and Cofactors of Human Neuronal Cell Fate Specification Identified by CRISPR Gene Activation Screens. Black JB, McCutcheon SR, Dube S, Barrera A, Klann TS, Rice GA, Adkar SS, Soderling SH, Reddy TE, Gersbach CA. Cell Rep. 2020 Dec 1;33(9):108460. doi: 10.1016/j.celrep.2020.108460. PubMed |
| A brainstem peptide system activated at birth protects postnatal breathing. Shi Y, Stornetta DS, Reklow RJ, Sahu A, Wabara Y, Nguyen A, Li K, Zhang Y, Perez-Reyes E, Ross RA, Lowell BB, Stornetta RL, Funk GD, Guyenet PG, Bayliss DA. Nature. 2021 Jan;589(7842):426-430. doi: 10.1038/s41586-020-2991-4. Epub 2020 Dec 2. PubMed |
| Patient-derived and artificial ascites have minor effects on MeT-5A mesothelial cells and do not facilitate ovarian cancer cell adhesion. Estermann M, Huang YL, Septiadi D, Ritz D, Liang CY, Jacob F, Drasler B, Petri-Fink A, Heinzelmann-Schwarz V, Rothen-Rutishauser B. PLoS One. 2020 Dec 3;15(12):e0241500. doi: 10.1371/journal.pone.0241500. eCollection 2020. PubMed |
| CRISPR screen identifies genes that sensitize AML cells to double-negative T-cell therapy. Soares F, Chen B, Lee JB, Ahmed M, Ly D, Tin E, Kang H, Zeng Y, Akhtar N, Minden MD, He HH, Zhang L. Blood. 2021 Apr 22;137(16):2171-2181. doi: 10.1182/blood.2019004108. PubMed |
| Silencing of the Long Noncoding RNA MYCNOS1 Suppresses Activity of MYCN-Amplified Retinoblastoma Without RB1 Mutation. Saengwimol D, Chittavanich P, Laosillapacharoen N, Srimongkol A, Chaitankar V, Rojanaporn D, Aroonroch R, Suktitipat B, Saisawang C, Svasti S, Hongeng S, Kaewkhaw R. Invest Ophthalmol Vis Sci. 2020 Dec 1;61(14):8. doi: 10.1167/iovs.61.14.8. PubMed |
| Genome-wide Screens Identify Lineage- and Tumor-Specific Genes Modulating MHC-I- and MHC-II-Restricted Immunosurveillance of Human Lymphomas. Dersh D, Phelan JD, Gumina ME, Wang B, Arbuckle JH, Holly J, Kishton RJ, Markowitz TE, Seedhom MO, Fridlyand N, Wright GW, Huang DW, Ceribelli M, Thomas CJ, Lack JB, Restifo NP, Kristie TM, Staudt LM, Yewdell JW. Immunity. 2021 Jan 12;54(1):116-131.e10. doi: 10.1016/j.immuni.2020.11.002. Epub 2020 Dec 2. PubMed |
| Identification of Potent CD19 scFv for CAR T Cells through scFv Screening with NK/T-Cell Line. Kang CH, Kim Y, Lee HK, Lee SM, Jeong HG, Choi SU, Park CH. Int J Mol Sci. 2020 Dec 1;21(23). pii: ijms21239163. doi: 10.3390/ijms21239163. PubMed |
| Revealing Temozolomide Resistance Mechanisms via Genome-Wide CRISPR Libraries. Rocha CRR, Reily Rocha A, Molina Silva M, Rodrigues Gomes L, Teatin Latancia M, Andrade Tomaz M, de Souza I, Karolynne Seregni Monteiro L, Menck CFM. Cells. 2020 Dec 1;9(12). pii: cells9122573. doi: 10.3390/cells9122573. PubMed |
| Pharmacologic Screening Identifies Metabolic Vulnerabilities of CD8(+) T Cells. Drijvers JM, Gillis JE, Muijlwijk T, Nguyen TH, Gaudiano EF, Harris IS, LaFleur MW, Ringel AE, Yao CH, Kurmi K, Juneja VR, Trombley JD, Haigis MC, Sharpe AH. Cancer Immunol Res. 2021 Feb;9(2):184-199. doi: 10.1158/2326-6066.CIR-20-0384. Epub 2020 Dec 4. PubMed |
| Growth of pancreatic cancers with hemizygous chromosomal 17p loss of MYBBP1A can be preferentially targeted by PARP inhibitors. Hsieh A, Pitarresi JR, Lerner J, Donahue G, Hsiehchen D, Rustgi AK, Zaret K. Sci Adv. 2020 Dec 4;6(49). pii: 6/49/eabc4517. doi: 10.1126/sciadv.abc4517. Print 2020 Dec. PubMed |
| Epigenetic activation of a RAS/MYC axis in H3.3K27M-driven cancer. Pajovic S, Siddaway R, Bridge T, Sheth J, Rakopoulos P, Kim B, Ryall S, Agnihotri S, Phillips L, Yu M, Li C, Milos S, Patel P, Srikanthan D, Huang A, Hawkins C. Nat Commun. 2020 Dec 4;11(1):6216. doi: 10.1038/s41467-020-19972-7. PubMed |
| Activating transcription factor-4 promotes neuronal death induced by Parkinson's disease neurotoxins and alpha-synuclein aggregates. Demmings MD, Tennyson EC, Petroff GN, Tarnowski-Garner HE, Cregan SP. Cell Death Differ. 2021 May;28(5):1627-1643. doi: 10.1038/s41418-020-00688-6. Epub 2020 Dec 4. PubMed |
| Wnt16 signaling promotes osteoblast differentiation of periosteal derived cells in vitro and in vivo. Jin Y, Sun X, Pei F, Zhao Z, Mao J. PeerJ. 2020 Nov 24;8:e10374. doi: 10.7717/peerj.10374. eCollection 2020. PubMed |
| Sterol and oxysterol synthases near the ciliary base activate the Hedgehog pathway. Findakly S, Daggubati V, Garcia G, LaStella SA, Choudhury A, Tran C, Li A, Tong P, Garcia JQ, Puri N, Reiter JF, Xu L, Raleigh DR. J Cell Biol. 2021 Jan 4;220(1). pii: 211576. doi: 10.1083/jcb.202002026. PubMed |
Binding and transport of SFPQ-RNA granules by KIF5A/KLC1 motors promotes axon survival.
Fukuda Y, Pazyra-Murphy MF, Silagi ES, Tasdemir-Yilmaz OE, Li Y, Rose L, Yeoh ZC, Vangos NE, Geffken EA, Seo HS, Adelmant G, Bird GH, Walensky LD, Marto JA, Dhe-Paganon S, Segal RA.
J Cell Biol. 2021 Jan 4;220(1). pii: 211577. doi: 10.1083/jcb.202005051.
PubMed
Associated Plasmids |
| Measuring Circadian Rhythms in Human Cells. Du NH, Brown SA. Methods Mol Biol. 2021;2130:53-67. doi: 10.1007/978-1-0716-0381-9_4. PubMed |
| Searching Novel Clock Genes Using RNAi-Based Screening. Maier B, Lorenzen S, Finger AM, Herzel H, Kramer A. Methods Mol Biol. 2021;2130:103-114. doi: 10.1007/978-1-0716-0381-9_8. PubMed |
| Intestinal region-specific Wnt signalling profiles reveal interrelation between cell identity and oncogenic pathway activity in cancer development. Adam RS, van Neerven SM, Pleguezuelos-Manzano C, Simmini S, Leveille N, de Groot NE, Holding AN, Markowetz F, Vermeulen L. Cancer Cell Int. 2020 Dec 3;20(1):578. doi: 10.1186/s12935-020-01661-6. PubMed |
| PD-L1 chimeric costimulatory receptor improves the efficacy of CAR-T cells for PD-L1-positive solid tumors and reduces toxicity in vivo. Liao Q, Mao Y, He H, Ding X, Zhang X, Xu J. Biomark Res. 2020 Nov 2;8(1):57. doi: 10.1186/s40364-020-00237-w. PubMed |
Arterialization requires the timely suppression of cell growth.
Luo W, Garcia-Gonzalez I, Fernandez-Chacon M, Casquero-Garcia V, Sanchez-Munoz MS, Muhleder S, Garcia-Ortega L, Andrade J, Potente M, Benedito R.
Nature. 2021 Jan;589(7842):437-441. doi: 10.1038/s41586-020-3018-x. Epub 2020 Dec 9.
PubMed
Associated Plasmids |
| Bidirectional perisomatic inhibitory plasticity of a Fos neuronal network. Yap EL, Pettit NL, Davis CP, Nagy MA, Harmin DA, Golden E, Dagliyan O, Lin C, Rudolph S, Sharma N, Griffith EC, Harvey CD, Greenberg ME. Nature. 2021 Feb;590(7844):115-121. doi: 10.1038/s41586-020-3031-0. Epub 2020 Dec 9. PubMed |
| Heterogeneous bone-marrow stromal progenitors drive myelofibrosis via a druggable alarmin axis. Leimkuhler NB, Gleitz HFE, Ronghui L, Snoeren IAM, Fuchs SNR, Nagai JS, Banjanin B, Lam KH, Vogl T, Kuppe C, Stalmann USA, Busche G, Kreipe H, Gutgemann I, Krebs P, Banz Y, Boor P, Tai EW, Brummendorf TH, Koschmieder S, Crysandt M, Bindels E, Kramann R, Costa IG, Schneider RK. Cell Stem Cell. 2021 Apr 1;28(4):637-652.e8. doi: 10.1016/j.stem.2020.11.004. Epub 2020 Dec 9. PubMed |
| A Novel Nonsense GLI3 Variant Is Associated With Polydactyly and Syndactyly in a Family by Blocking the Sonic Hedgehog Signaling Pathway. Xiang Y, Li X, Zhan Z, Feng J, Cai H, Li Y, Fu Q, Xu Y, Jiang H, Zhang X. Front Genet. 2020 Nov 10;11:542004. doi: 10.3389/fgene.2020.542004. eCollection 2020. PubMed |
| Inhibition of Wnt signaling by Frizzled7 antibody-coated nanoshells sensitizes triple-negative breast cancer cells to the autophagy regulator chloroquine. Wang J, Dang MN, Day ES. Nano Res. 2020 Jun;13(6):1693-1703. doi: 10.1007/s12274-020-2795-8. Epub 2020 Apr 25. PubMed |
| The long non-coding RNA LUCAT1 is a negative feedback regulator of interferon responses in humans. Agarwal S, Vierbuchen T, Ghosh S, Chan J, Jiang Z, Kandasamy RK, Ricci E, Fitzgerald KA. Nat Commun. 2020 Dec 11;11(1):6348. doi: 10.1038/s41467-020-20165-5. PubMed |
| SNAIL regulates gastric carcinogenesis through CCN3 and NEFL. Chen R, Masuo K, Yogo A, Yokoyama S, Sugiyama A, Seno H, Yoshizawa A, Takaishi S. Carcinogenesis. 2021 Feb 25;42(2):190-201. doi: 10.1093/carcin/bgaa133. PubMed |
| Satellite cell expansion is mediated by P-eIF2alpha-dependent Tacc3 translation. Fujita R, Jamet S, Lean G, Cheng HCM, Hebert S, Kleinman CL, Crist C. Development. 2021 Jan 20;148(2). pii: dev.194480. doi: 10.1242/dev.194480. PubMed |
| Genome-Scale Perturbation of Long Noncoding RNA Expression Using CRISPR Interference. Liu SJ, Horlbeck MA, Weissman JS, Lim DA. Methods Mol Biol. 2021;2254:323-338. doi: 10.1007/978-1-0716-1158-6_20. PubMed |
Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q.
Neggers JE, Paolella BR, Asfaw A, Rothberg MV, Skipper TA, Yang A, Kalekar RL, Krill-Burger JM, Dharia NV, Kugener G, Kalfon J, Yuan C, Dumont N, Gonzalez A, Abdusamad M, Li YY, Spurr LF, Wu WW, Durbin AD, Wolpin BM, Piccioni F, Root DE, Boehm JS, Cherniack AD, Tsherniak A, Hong AL, Hahn WC, Stegmaier K, Golub TR, Vazquez F, Aguirre AJ.
Cell Rep. 2020 Dec 15;33(11):108493. doi: 10.1016/j.celrep.2020.108493.
PubMed
Associated Plasmids |
| An activity-dependent local transport regulation via degradation and synthesis of KIF17 underlying cognitive flexibility. Iwata S, Morikawa M, Takei Y, Hirokawa N. Sci Adv. 2020 Dec 16;6(51). pii: 6/51/eabc8355. doi: 10.1126/sciadv.abc8355. Print 2020 Dec. PubMed |
| Erythroid Differentiation and Heme Biosynthesis Are Dependent on a Shift in the Balance of Mitochondrial Fusion and Fission Dynamics. Gonzalez-Ibanez AM, Ruiz LM, Jensen E, Echeverria CA, Romero V, Stiles L, Shirihai OS, Elorza AA. Front Cell Dev Biol. 2020 Nov 23;8:592035. doi: 10.3389/fcell.2020.592035. eCollection 2020. PubMed |
| USP13 interacts with cohesin and regulates its ubiquitination in human cells. He X, Kim JS, Diaz-Martinez LA, Han C, Lane WS, Budnik B, Waldman T. J Biol Chem. 2021 Jan-Jun;296:100194. doi: 10.1074/jbc.RA120.015762. Epub 2020 Dec 20. PubMed |
| Enhancing cardiac reprogramming via synthetic RNA oligonucleotides. Hu J, Hodgkinson CP, Pratt RE, Lee J, Sullenger BA, Dzau VJ. Mol Ther Nucleic Acids. 2020 Oct 27;23:55-62. doi: 10.1016/j.omtn.2020.10.034. eCollection 2021 Mar 5. PubMed |
| The TOP vector: a new high-titer lentiviral construct for delivery of sgRNAs and transgenes to primary T cells. Humes D, Rainwater S, Overbaugh J. Mol Ther Methods Clin Dev. 2020 Oct 27;20:30-38. doi: 10.1016/j.omtm.2020.10.020. eCollection 2021 Mar 12. PubMed |
| TMEM41B Is a Pan-flavivirus Host Factor. Hoffmann HH, Schneider WM, Rozen-Gagnon K, Miles LA, Schuster F, Razooky B, Jacobson E, Wu X, Yi S, Rudin CM, MacDonald MR, McMullan LK, Poirier JT, Rice CM. Cell. 2021 Jan 7;184(1):133-148.e20. doi: 10.1016/j.cell.2020.12.005. Epub 2020 Dec 9. PubMed |
| Resveratrol Activates Natural Killer Cells through Akt- and mTORC2-Mediated c-Myb Upregulation. Lee YJ, Kim J. Int J Mol Sci. 2020 Dec 16;21(24). pii: ijms21249575. doi: 10.3390/ijms21249575. PubMed |
| ANKRD26 recruits PIDD1 to centriolar distal appendages to activate the PIDDosome following centrosome amplification. Evans LT, Anglen T, Scott P, Lukasik K, Loncarek J, Holland AJ. EMBO J. 2021 Feb 15;40(4):e105106. doi: 10.15252/embj.2020105106. Epub 2020 Dec 22. PubMed |
| Separate signaling events control TCR downregulation and T cell activation in primary human T cells. van der Donk LEH, Ates LS, van der Spek J, Tukker LM, Geijtenbeek TBH, van Heijst JWJ. Immun Inflamm Dis. 2021 Mar;9(1):223-238. doi: 10.1002/iid3.383. Epub 2020 Dec 22. PubMed |
| Clustering of desmosomal cadherins by desmoplakin is essential for cell-cell adhesion. Wanuske MT, Brantschen D, Schinner C, Studle C, Walter E, Hiermaier M, Vielmuth F, Waschke J, Spindler V. Acta Physiol (Oxf). 2021 Apr;231(4):e13609. doi: 10.1111/apha.13609. Epub 2021 Jan 19. PubMed |
| Susceptibility of rabbits to SARS-CoV-2. Mykytyn AZ, Lamers MM, Okba NMA, Breugem TI, Schipper D, van den Doel PB, van Run P, van Amerongen G, de Waal L, Koopmans MPG, Stittelaar KJ, van den Brand JMA, Haagmans BL. Emerg Microbes Infect. 2021 Dec;10(1):1-7. doi: 10.1080/22221751.2020.1868951. PubMed |
| Manipulation of the human tRNA pool reveals distinct tRNA sets that act in cellular proliferation or cell cycle arrest. Aharon-Hefetz N, Frumkin I, Mayshar Y, Dahan O, Pilpel Y, Rak R. Elife. 2020 Dec 24;9. pii: 58461. doi: 10.7554/eLife.58461. PubMed |
| Massively parallel functional testing of MSH2 missense variants conferring Lynch syndrome risk. Jia X, Burugula BB, Chen V, Lemons RM, Jayakody S, Maksutova M, Kitzman JO. Am J Hum Genet. 2021 Jan 7;108(1):163-175. doi: 10.1016/j.ajhg.2020.12.003. Epub 2020 Dec 23. PubMed |
| Immunogenic Chemotherapy Enhances Recruitment of CAR-T Cells to Lung Tumors and Improves Antitumor Efficacy when Combined with Checkpoint Blockade. Srivastava S, Furlan SN, Jaeger-Ruckstuhl CA, Sarvothama M, Berger C, Smythe KS, Garrison SM, Specht JM, Lee SM, Amezquita RA, Voillet V, Muhunthan V, Yechan-Gunja S, Pillai SPS, Rader C, Houghton AM, Pierce RH, Gottardo R, Maloney DG, Riddell SR. Cancer Cell. 2021 Feb 8;39(2):193-208.e10. doi: 10.1016/j.ccell.2020.11.005. Epub 2020 Dec 24. PubMed |
| Discovery of cellular substrates of human RNA-decapping enzyme DCP2 using a stapled bicyclic peptide inhibitor. Luo Y, Schofield JA, Na Z, Hann T, Simon MD, Slavoff SA. Cell Chem Biol. 2021 Apr 15;28(4):463-474.e7. doi: 10.1016/j.chembiol.2020.12.003. Epub 2020 Dec 22. PubMed |
| A CRISPR-Cas13a Based Strategy That Tracks and Degrades Toxic RNA in Myotonic Dystrophy Type 1. Zhang N, Bewick B, Xia G, Furling D, Ashizawa T. Front Genet. 2020 Dec 10;11:594576. doi: 10.3389/fgene.2020.594576. eCollection 2020. PubMed |
| Modeling Rett Syndrome With Human Patient-Specific Forebrain Organoids. Gomes AR, Fernandes TG, Vaz SH, Silva TP, Bekman EP, Xapelli S, Duarte S, Ghazvini M, Gribnau J, Muotri AR, Trujillo CA, Sebastiao AM, Cabral JMS, Diogo MM. Front Cell Dev Biol. 2020 Dec 10;8:610427. doi: 10.3389/fcell.2020.610427. eCollection 2020. PubMed |
| Lentiviral vector with a radiation-inducible promoter, carrying the ING4 gene, mediates radiosensitization controlled by radiotherapy in cervical cancer cells. Ma T, Guo R, Wang X, Shen WT, Zhu M, Jin YN, Xu HP. Oncol Lett. 2021 Jan;21(1):67. doi: 10.3892/ol.2020.12328. Epub 2020 Nov 25. PubMed |
| USP22 controls necroptosis by regulating receptor-interacting protein kinase 3 ubiquitination. Roedig J, Kowald L, Juretschke T, Karlowitz R, Ahangarian Abhari B, Roedig H, Fulda S, Beli P, van Wijk SJ. EMBO Rep. 2021 Feb 3;22(2):e50163. doi: 10.15252/embr.202050163. Epub 2020 Dec 28. PubMed |
| Differential effects of RASA3 mutations on hematopoiesis are profoundly influenced by genetic background and molecular variant. Robledo RF, Ciciotte SL, Graber JH, Zhao Y, Lambert AJ, Gwynn B, Maki NJ, Brindley EC, Hartman E, Blanc L, Peters LL. PLoS Genet. 2020 Dec 28;16(12):e1008857. doi: 10.1371/journal.pgen.1008857. eCollection 2020 Dec. PubMed |
| Differential Regulation of Cancer Progression by CDK4/6 Plays a Central Role in DNA Replication and Repair Pathways. Dai M, Boudreault J, Wang N, Poulet S, Daliah G, Yan G, Moamer A, Burgos SA, Sabri S, Ali S, Lebrun JJ. Cancer Res. 2021 Mar 1;81(5):1332-1346. doi: 10.1158/0008-5472.CAN-20-2121. Epub 2020 Dec 28. PubMed |
| Evaluation of Structurally Distorted Split GFP Fluorescent Sensors for Cell-Based Detection of Viral Proteolytic Activity. Guerreiro MR, Fernandes AR, Coroadinha AS. Sensors (Basel). 2020 Dec 23;21(1). pii: s21010024. doi: 10.3390/s21010024. PubMed |
| Genetic engineering of human and mouse CD4(+) and CD8(+) Tregs using lentiviral vectors encoding chimeric antigen receptors. Vimond N, Lasselin J, Anegon I, Guillonneau C, Bezie S. Mol Ther Methods Clin Dev. 2020 Nov 17;20:69-85. doi: 10.1016/j.omtm.2020.11.008. eCollection 2021 Mar 12. PubMed |
| An Improved Protocol for the Production of Lentiviral Vectors. Brown LY, Dong W, Kantor B. STAR Protoc. 2020 Oct 27;1(3):100152. doi: 10.1016/j.xpro.2020.100152. eCollection 2020 Dec 18. PubMed |
| P2X-GCaMPs as Versatile Tools for Imaging Extracellular ATP Signaling. Ollivier M, Beudez J, Linck N, Grutter T, Compan V, Rassendren F. eNeuro. 2021 Jan 28;8(1). pii: ENEURO.0185-20.2020. doi: 10.1523/ENEURO.0185-20.2020. Print 2021 Jan-Feb. PubMed |
| LncRNA FTX Promotes Colorectal Cancer Cells Migration and Invasion by miRNA-590-5p/RBPJ Axis. Chen GQ, Liao ZM, Liu J, Li F, Huang D, Zhou YD. Biochem Genet. 2021 Apr;59(2):560-573. doi: 10.1007/s10528-020-10017-8. Epub 2021 Jan 3. PubMed |
| SARS-CoV-2 entry into human airway organoids is serine protease-mediated and facilitated by the multibasic cleavage site. Mykytyn AZ, Breugem TI, Riesebosch S, Schipper D, van den Doel PB, Rottier RJ, Lamers MM, Haagmans BL. Elife. 2021 Jan 4;10. pii: 64508. doi: 10.7554/eLife.64508. PubMed |
| Transcriptional regulation of VEGFA expression in T-regulatory cells from breast cancer patients. Kajal K, Bose S, Panda AK, Chakraborty D, Chakraborty S, Pati S, Sarkar T, Dhar S, Roy D, Saha S, Sa G. Cancer Immunol Immunother. 2021 Jul;70(7):1877-1891. doi: 10.1007/s00262-020-02808-0. Epub 2021 Jan 4. PubMed |
| ZBP1 promotes LPS-induced cell death and IL-1beta release via RHIM-mediated interactions with RIPK1. Muendlein HI, Connolly WM, Magri Z, Smirnova I, Ilyukha V, Gautam A, Degterev A, Poltorak A. Nat Commun. 2021 Jan 4;12(1):86. doi: 10.1038/s41467-020-20357-z. PubMed |
| Functional Genomics Identify Distinct and Overlapping Genes Mediating Resistance to Different Classes of Heterobifunctional Degraders of Oncoproteins. Shirasaki R, Matthews GM, Gandolfi S, de Matos Simoes R, Buckley DL, Raja Vora J, Sievers QL, Bruggenthies JB, Dashevsky O, Poarch H, Tang H, Bariteau MA, Sheffer M, Hu Y, Downey-Kopyscinski SL, Hengeveld PJ, Glassner BJ, Dhimolea E, Ott CJ, Zhang T, Kwiatkowski NP, Laubach JP, Schlossman RL, Richardson PG, Culhane AC, Groen RWJ, Fischer ES, Vazquez F, Tsherniak A, Hahn WC, Levy J, Auclair D, Licht JD, Keats JJ, Boise LH, Ebert BL, Bradner JE, Gray NS, Mitsiades CS. Cell Rep. 2021 Jan 5;34(1):108532. doi: 10.1016/j.celrep.2020.108532. PubMed |
| Endothelial Klf2-Foxp1-TGFbeta signal mediates the inhibitory effects of simvastatin on maladaptive cardiac remodeling. Li H, Wang Y, Liu J, Chen X, Duan Y, Wang X, Shen Y, Kuang Y, Zhuang T, Tomlinson B, Chan P, Yu Z, Cheng Y, Zhang L, Liu Z, Zhang Y, Zhao Z, Zhang Q, Liu J. Theranostics. 2021 Jan 1;11(4):1609-1625. doi: 10.7150/thno.48153. eCollection 2021. PubMed |
| Mechanism and restoration strategy of lysosomal abnormalities induced by urinary protein overload in proximal tubule epithelial cells. Li X, Zou T, Wang S, Wu H, Wu M, Liu Z, Liu H. Dev Dyn. 2021 Jan 6. doi: 10.1002/dvdy.297. PubMed |
| The serine-48 residue of nucleolar phosphoprotein nucleophosmin-1 plays critical role in subcellular localization and interaction with porcine circovirus type 3 capsid protein. Zhou J, Li J, Li H, Zhang Y, Dong W, Jin Y, Yan Y, Gu J, Zhou J. Vet Res. 2021 Jan 7;52(1):4. doi: 10.1186/s13567-020-00876-9. PubMed |
| Ferroptosis induces membrane blebbing in placental trophoblasts. Kajiwara K, Beharier O, Chng CP, Goff JP, Ouyang Y, St Croix CM, Huang C, Kagan VE, Hsia KJ, Sadovsky Y. J Cell Sci. 2022 Mar 1;135(5). pii: jcs.255737. doi: 10.1242/jcs.255737. Epub 2021 Apr 20. PubMed |
| Inhibition of caspase-3-mediated GSDME-derived pyroptosis aids in noncancerous tissue protection of squamous cell carcinoma patients during cisplatin-based chemotherapy. Huang Z, Zhang Q, Wang Y, Chen R, Wang Y, Huang Z, Zhou G, Li H, Rui X, Jin T, Li S, Zhang Y, Huang Z. Am J Cancer Res. 2020 Dec 1;10(12):4287-4307. eCollection 2020. PubMed |
| Directly Reprogrammed Neurons Express MAPT and APP Splice Variants Pertinent to Ageing and Neurodegeneration. Habekost M, Qvist P, Denham M, Holm IE, Jorgensen AL. Mol Neurobiol. 2021 May;58(5):2075-2087. doi: 10.1007/s12035-020-02258-w. Epub 2021 Jan 7. PubMed |
| Interaction between SNAI2 and MYOD enhances oncogenesis and suppresses differentiation in Fusion Negative Rhabdomyosarcoma. Pomella S, Sreenivas P, Gryder BE, Wang L, Milewski D, Cassandri M, Baxi K, Hensch NR, Carcarino E, Song Y, Chou HC, Yohe ME, Stanton BZ, Amadio B, Caruana I, De Stefanis C, De Vito R, Locatelli F, Chen Y, Chen EY, Houghton P, Khan J, Rota R, Ignatius MS. Nat Commun. 2021 Jan 8;12(1):192. doi: 10.1038/s41467-020-20386-8. PubMed |
| SLE non-coding genetic risk variant determines the epigenetic dysfunction of an immune cell specific enhancer that controls disease-critical microRNA expression. Hou G, Harley ITW, Lu X, Zhou T, Xu N, Yao C, Qin Y, Ouyang Y, Ma J, Zhu X, Yu X, Xu H, Dai D, Ding H, Yin Z, Ye Z, Deng J, Zhou M, Tang Y, Namjou B, Guo Y, Weirauch MT, Kottyan LC, Harley JB, Shen N. Nat Commun. 2021 Jan 8;12(1):135. doi: 10.1038/s41467-020-20460-1. PubMed |
| PRMT1 enhances oncogenic arginine methylation of NONO in colorectal cancer. Yin XK, Wang YL, Wang F, Feng WX, Bai SM, Zhao WW, Feng LL, Wei MB, Qin CL, Wang F, Chen ZL, Yi HJ, Huang Y, Xie PY, Kim T, Wang YN, Hou JW, Li CW, Liu Q, Fan XJ, Hung MC, Wan XB. Oncogene. 2021 Feb;40(7):1375-1389. doi: 10.1038/s41388-020-01617-0. Epub 2021 Jan 8. PubMed |
| The TGF-beta superfamily cytokine Activin-A is induced during autoimmune neuroinflammation and drives pathogenic Th17 cell differentiation. Wu B, Zhang S, Guo Z, Bi Y, Zhou M, Li P, Seyedsadr M, Xu X, Li JL, Markovic-Plese S, Wan YY. Immunity. 2021 Feb 9;54(2):308-323.e6. doi: 10.1016/j.immuni.2020.12.010. Epub 2021 Jan 8. PubMed |
| Temperature is a key determinant of alpha- and beta-synuclein membrane interactions in neurons. Ramalingam N, Dettmer U. J Biol Chem. 2021 Jan-Jun;296:100271. doi: 10.1016/j.jbc.2021.100271. Epub 2021 Jan 9. PubMed |
| Ectopic Expression of Genotype 1 Hepatitis E Virus ORF4 Increases Genotype 3 HEV Viral Replication in Cell Culture. Yadav KK, Boley PA, Fritts Z, Kenney SP. Viruses. 2021 Jan 7;13(1). pii: v13010075. doi: 10.3390/v13010075. PubMed |
| Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape. Koenig PA, Das H, Liu H, Kummerer BM, Gohr FN, Jenster LM, Schiffelers LDJ, Tesfamariam YM, Uchima M, Wuerth JD, Gatterdam K, Ruetalo N, Christensen MH, Fandrey CI, Normann S, Todtmann JMP, Pritzl S, Hanke L, Boos J, Yuan M, Zhu X, Schmid-Burgk JL, Kato H, Schindler M, Wilson IA, Geyer M, Ludwig KU, Hallberg BM, Wu NC, Schmidt FI. Science. 2021 Feb 12;371(6530). pii: science.abe6230. doi: 10.1126/science.abe6230. Epub 2021 Jan 12. PubMed |
| Enhanced Expression of miR-181b in B Cells of CLL Improves the Anti-Tumor Cytotoxic T Cell Response. Di Marco M, Veschi S, Lanuti P, Ramassone A, Pacillo S, Pagotto S, Pepe F, George-William JN, Curcio C, Marchisio M, Miscia S, Innocenti I, Autore F, Vannata B, Di Gregorio P, Di Gioacchino M, Valentinuzzi S, Iezzi M, Mariani-Costantini R, Larocca LM, Laurenti L, Veronese A, Visone R. Cancers (Basel). 2021 Jan 12;13(2). pii: cancers13020257. doi: 10.3390/cancers13020257. PubMed |
| SIX2 and SIX3 coordinately regulate functional maturity and fate of human pancreatic beta cells. Bevacqua RJ, Lam JY, Peiris H, Whitener RL, Kim S, Gu X, Friedlander MSH, Kim SK. Genes Dev. 2021 Feb 1;35(3-4):234-249. doi: 10.1101/gad.342378.120. Epub 2021 Jan 14. PubMed |
| HAND1 and BARX1 Act as Transcriptional and Anatomic Determinants of Malignancy in Gastrointestinal Stromal Tumor. Hemming ML, Coy S, Lin JR, Andersen JL, Przybyl J, Mazzola E, Abdelhamid Ahmed AH, van de Rijn M, Sorger PK, Armstrong SA, Demetri GD, Santagata S. Clin Cancer Res. 2021 Mar 15;27(6):1706-1719. doi: 10.1158/1078-0432.CCR-20-3538. Epub 2021 Jan 15. PubMed |
| m(6) A deposition is regulated by PRMT1-mediated arginine methylation of METTL14 in its disordered C-terminal region. Wang Z, Pan Z, Adhikari S, Harada BT, Shen L, Yuan W, Abeywardana T, Al-Hadid Q, Stark JM, He C, Lin L, Yang Y. EMBO J. 2021 Mar 1;40(5):e106309. doi: 10.15252/embj.2020106309. Epub 2021 Jan 18. PubMed |
| Autophagy activation, lipotoxicity and lysosomal membrane permeabilization synergize to promote pimozide- and loperamide-induced glioma cell death. Meyer N, Henkel L, Linder B, Zielke S, Tascher G, Trautmann S, Geisslinger G, Munch C, Fulda S, Tegeder I, Kogel D. Autophagy. 2021 Nov;17(11):3424-3443. doi: 10.1080/15548627.2021.1874208. Epub 2021 Jan 19. PubMed |
| Deletion of Cbl-b inhibits CD8(+) T-cell exhaustion and promotes CAR T-cell function. Kumar J, Kumar R, Kumar Singh A, Tsakem EL, Kathania M, Riese MJ, Theiss AL, Davila ML, Venuprasad K. J Immunother Cancer. 2021 Jan;9(1). pii: jitc-2020-001688. doi: 10.1136/jitc-2020-001688. PubMed |
| Tetracyclines promote survival and fitness in mitochondrial disease models. Perry EA, Bennett CF, Luo C, Balsa E, Jedrychowski M, O'Malley KE, Latorre-Muro P, Ladley RP, Reda K, Wright PM, Gygi SP, Myers AG, Puigserver P. Nat Metab. 2021 Jan;3(1):33-42. doi: 10.1038/s42255-020-00334-y. Epub 2021 Jan 18. PubMed |
| Cross-talk Between Histone and DNA Methylation Mediates Bone Loss in Hind Limb Unloading. Li B, Zhao J, Ma J, Chen W, Zhou C, Wei W, Li S, Li G, Xin G, Zhang Y, Liu J, Wang Y, Ma X. J Bone Miner Res. 2021 May;36(5):956-967. doi: 10.1002/jbmr.4253. Epub 2021 Feb 10. PubMed |
| The phosphatidylinositol 3-phosphate-binding protein SNX4 controls ATG9A recycling and autophagy. Ravussin A, Brech A, Tooze SA, Stenmark H. J Cell Sci. 2021 Feb 10;134(3). pii: jcs.250670. doi: 10.1242/jcs.250670. PubMed |
CRNKL1 Is a Highly Selective Regulator of Intron-Retaining HIV-1 and Cellular mRNAs.
Xiao H, Wyler E, Milek M, Grewe B, Kirchner P, Ekici A, Silva ABOV, Jungnickl D, Full F, Thomas M, Landthaler M, Ensser A, Uberla K.
mBio. 2021 Jan 19;12(1). pii: mBio.02525-20. doi: 10.1128/mBio.02525-20.
PubMed
Associated Plasmids |
| A DYRK1B-dependent pathway suppresses rDNA transcription in response to DNA damage. Dong C, An L, Yu CH, Huen MSY. Nucleic Acids Res. 2021 Feb 22;49(3):1485-1496. doi: 10.1093/nar/gkaa1290. PubMed |
ER-directed TREX1 limits cGAS activation at micronuclei.
Mohr L, Toufektchan E, von Morgen P, Chu K, Kapoor A, Maciejowski J.
Mol Cell. 2021 Jan 12. pii: S1097-2765(20)30958-8. doi: 10.1016/j.molcel.2020.12.037.
PubMed
Associated Plasmids |
| Further evidence supporting a potential role for ADH1B in obesity. Morales LD, Cromack DT, Tripathy D, Fourcaudot M, Kumar S, Curran JE, Carless M, Goring HHH, Hu SL, Lopez-Alvarenga JC, Garske KM, Pajukanta P, Small KS, Glastonbury CA, Das SK, Langefeld C, Hanson RL, Hsueh WC, Norton L, Arya R, Mummidi S, Blangero J, DeFronzo RA, Duggirala R, Jenkinson CP. Sci Rep. 2021 Jan 21;11(1):1932. doi: 10.1038/s41598-020-80563-z. PubMed |
| T cell receptor-dependent S-acylation of ZAP-70 controls activation of T cells. Tewari R, Shayahati B, Fan Y, Akimzhanov AM. J Biol Chem. 2021 Jan-Jun;296:100311. doi: 10.1016/j.jbc.2021.100311. Epub 2021 Jan 19. PubMed |
| BMI1 enables extensive expansion of functional erythroblasts from human peripheral blood mononuclear cells. Liu S, Wu M, Lancelot M, Deng J, Gao Y, Roback JD, Chen T, Cheng L. Mol Ther. 2021 May 5;29(5):1918-1932. doi: 10.1016/j.ymthe.2021.01.022. Epub 2021 Jan 21. PubMed |
| Furin cleavage of SARS-CoV-2 Spike promotes but is not essential for infection and cell-cell fusion. Papa G, Mallery DL, Albecka A, Welch LG, Cattin-Ortola J, Luptak J, Paul D, McMahon HT, Goodfellow IG, Carter A, Munro S, James LC. PLoS Pathog. 2021 Jan 25;17(1):e1009246. doi: 10.1371/journal.ppat.1009246. eCollection 2021 Jan. PubMed |
| Evasion of Innate Immunity Contributes to Small Cell Lung Cancer Progression and Metastasis. Zhu M, Huang Y, Bender ME, Girard L, Kollipara R, Eglenen-Polat B, Naito Y, Savage TK, Huffman KE, Koyama S, Kumanogoh A, Minna JD, Johnson JE, Akbay EA. Cancer Res. 2021 Apr 1;81(7):1813-1826. doi: 10.1158/0008-5472.CAN-20-2808. Epub 2021 Jan 25. PubMed |
| SFPQ regulates the accumulation of RNA foci and dipeptide repeat proteins from the expanded repeat mutation in C9orf72. Malnar M, Rogelj B. J Cell Sci. 2021 Feb 19;134(4). pii: jcs.256602. doi: 10.1242/jcs.256602. PubMed |
| DHODH inhibition synergizes with DNA-demethylating agents in the treatment of myelodysplastic syndromes. Kayamori K, Nagai Y, Zhong C, Kaito S, Shinoda D, Koide S, Kuribayashi W, Oshima M, Nakajima-Takagi Y, Yamashita M, Mimura N, Becker HJ, Izawa K, Yamazaki S, Iwano S, Miyawaki A, Ito R, Tohyama K, Lennox W, Sheedy J, Weetall M, Sakaida E, Yokote K, Iwama A. Blood Adv. 2021 Jan 26;5(2):438-450. doi: 10.1182/bloodadvances.2020001461. PubMed |
| G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling. Prentzell MT, Rehbein U, Cadena Sandoval M, De Meulemeester AS, Baumeister R, Brohee L, Berdel B, Bockwoldt M, Carroll B, Chowdhury SR, von Deimling A, Demetriades C, Figlia G, de Araujo MEG, Heberle AM, Heiland I, Holzwarth B, Huber LA, Jaworski J, Kedra M, Kern K, Kopach A, Korolchuk VI, van 't Land-Kuper I, Macias M, Nellist M, Palm W, Pusch S, Ramos Pittol JM, Reil M, Reintjes A, Reuter F, Sampson JR, Scheldeman C, Siekierska A, Stefan E, Teleman AA, Thomas LE, Torres-Quesada O, Trump S, West HD, de Witte P, Woltering S, Yordanov TE, Zmorzynska J, Opitz CA, Thedieck K. Cell. 2021 Feb 4;184(3):655-674.e27. doi: 10.1016/j.cell.2020.12.024. Epub 2021 Jan 25. PubMed |
| The Novel ALG-2 Target Protein CDIP1 Promotes Cell Death by Interacting with ESCRT-I and VAPA/B. Inukai R, Mori K, Kuwata K, Suzuki C, Maki M, Takahara T, Shibata H. Int J Mol Sci. 2021 Jan 25;22(3). pii: ijms22031175. doi: 10.3390/ijms22031175. PubMed |
| IDH1 mutations induce organelle defects via dysregulated phospholipids. Lita A, Pliss A, Kuzmin A, Yamasaki T, Zhang L, Dowdy T, Burks C, de Val N, Celiku O, Ruiz-Rodado V, Nicoli ER, Kruhlak M, Andresson T, Das S, Yang C, Schmitt R, Herold-Mende C, Gilbert MR, Prasad PN, Larion M. Nat Commun. 2021 Jan 27;12(1):614. doi: 10.1038/s41467-020-20752-6. PubMed |
| TALEN outperforms Cas9 in editing heterochromatin target sites. Jain S, Shukla S, Yang C, Zhang M, Fatma Z, Lingamaneni M, Abesteh S, Lane ST, Xiong X, Wang Y, Schroeder CM, Selvin PR, Zhao H. Nat Commun. 2021 Jan 27;12(1):606. doi: 10.1038/s41467-020-20672-5. PubMed |
| Depletion of Survivin suppresses docetaxel-induced apoptosis in HeLa cells by facilitating mitotic slippage. Han TL, Sha H, Ji J, Li YT, Wu DS, Lin H, Hu B, Jiang ZX. Sci Rep. 2021 Jan 27;11(1):2283. doi: 10.1038/s41598-021-81563-3. PubMed |
| A host receptor enables type 1 pilus-mediated pathogenesis of Escherichia coli pyelonephritis. McLellan LK, McAllaster MR, Kim AS, Tothova L, Olson PD, Pinkner JS, Daugherty AL, Hreha TN, Janetka JW, Fremont DH, Hultgren SJ, Virgin HW, Hunstad DA. PLoS Pathog. 2021 Jan 29;17(1):e1009314. doi: 10.1371/journal.ppat.1009314. eCollection 2021 Jan. PubMed |
| Prototypical oncogene family Myc defines unappreciated distinct lineage states of small cell lung cancer. Patel AS, Yoo S, Kong R, Sato T, Sinha A, Karam S, Bao L, Fridrikh M, Emoto K, Nudelman G, Powell CA, Beasley MB, Zhu J, Watanabe H. Sci Adv. 2021 Jan 29;7(5). pii: 7/5/eabc2578. doi: 10.1126/sciadv.abc2578. Print 2021 Jan. PubMed |
Plexin-B2 facilitates glioblastoma infiltration by modulating cell biomechanics.
Huang Y, Tejero R, Lee VK, Brusco C, Hannah T, Bertucci TB, Junqueira Alves C, Katsyv I, Kluge M, Foty R, Zhang B, Friedel CC, Dai G, Zou H, Friedel RH.
Commun Biol. 2021 Jan 29;4(1):145. doi: 10.1038/s42003-021-01667-4.
PubMed
Associated Plasmids |
| LncRNA H19 Suppresses Osteosarcomagenesis by Regulating snoRNAs and DNA Repair Protein Complexes. Xu A, Huang MF, Zhu D, Gingold JA, Bazer DA, Chang B, Wang D, Lai CC, Lemischka IR, Zhao R, Lee DF. Front Genet. 2021 Jan 15;11:611823. doi: 10.3389/fgene.2020.611823. eCollection 2020. PubMed |
| Generation of SARS-CoV-2 Spike Pseudotyped Virus for Viral Entry and Neutralization Assays: A 1-Week Protocol. Condor Capcha JM, Lambert G, Dykxhoorn DM, Salerno AG, Hare JM, Whitt MA, Pahwa S, Jayaweera DT, Shehadeh LA. Front Cardiovasc Med. 2021 Jan 15;7:618651. doi: 10.3389/fcvm.2020.618651. eCollection 2020. PubMed |
| SATB2 induction of a neural crest mesenchyme-like program drives melanoma invasion and drug resistance. Fazio M, van Rooijen E, Dang M, van de Hoek G, Ablain J, Mito JK, Yang S, Thomas A, Michael J, Fabo T, Modhurima R, Pessina P, Kaufman CK, Zhou Y, White RM, Zon LI. Elife. 2021 Feb 2;10. pii: 64370. doi: 10.7554/eLife.64370. PubMed |
| RNF168 regulates R-loop resolution and genomic stability in BRCA1/2-deficient tumors. Patel PS, Abraham KJ, Guturi KKN, Halaby MJ, Khan Z, Palomero L, Ho B, Duan S, St-Germain J, Algouneh A, Mateo F, El Ghamrasni S, Barbour H, Barnes DR, Beesley J, Sanchez O, Berman HK, Brown GW, Affar EB, Chenevix-Trench G, Antoniou AC, Arrowsmith CH, Raught B, Pujana MA, Mekhail K, Hakem A, Hakem R. J Clin Invest. 2021 Feb 1;131(3). pii: 140105. doi: 10.1172/JCI140105. PubMed |
| ATF3 downmodulates its new targets IFI6 and IFI27 to suppress the growth and migration of tongue squamous cell carcinoma cells. Xu L, Zu T, Li T, Li M, Mi J, Bai F, Liu G, Wen J, Li H, Brakebusch C, Wang X, Wu X. PLoS Genet. 2021 Feb 4;17(2):e1009283. doi: 10.1371/journal.pgen.1009283. eCollection 2021 Feb. PubMed |
| PTEN is required for the migration and invasion of Ras-transformed MDCK cells. Yan L, Tsujita K, Fujita Y, Itoh T. FEBS Lett. 2021 May;595(9):1303-1312. doi: 10.1002/1873-3468.14053. Epub 2021 Feb 20. PubMed |
| Distinct roles for the RNA-binding protein Staufen1 in prostate cancer. Marcellus KA, Crawford Parks TE, Almasi S, Jasmin BJ. BMC Cancer. 2021 Feb 4;21(1):120. doi: 10.1186/s12885-021-07844-2. PubMed |
| Engineering advanced logic and distributed computing in human CAR immune cells. Cho JH, Okuma A, Sofjan K, Lee S, Collins JJ, Wong WW. Nat Commun. 2021 Feb 4;12(1):792. doi: 10.1038/s41467-021-21078-7. PubMed |
| Discovery of Zika virus host dependency factors in trophoblasts using CRISPR/Cas9 screening. Rother M, Dimmler C, Weege F, Mollenkopf HJ, Meyer TF, Naumann M. J Virol Methods. 2021 Apr;290:114085. doi: 10.1016/j.jviromet.2021.114085. Epub 2021 Feb 2. PubMed |
| NAMPT/SIRT2-mediated inhibition of the p53-p21 signaling pathway is indispensable for maintenance and hematopoietic differentiation of human iPS cells. Xu Y, Nasri M, Dannenmann B, Mir P, Zahabi A, Welte K, Morishima T, Skokowa J. Stem Cell Res Ther. 2021 Feb 5;12(1):112. doi: 10.1186/s13287-021-02144-9. PubMed |
| Toll-like receptor 4 signaling activates ERG function in prostate cancer and provides a therapeutic target. Greulich BM, Plotnik JP, Jerde TJ, Hollenhorst PC. NAR Cancer. 2021 Jan 27;3(1):zcaa046. doi: 10.1093/narcan/zcaa046. eCollection 2021 Mar. PubMed |
| Optimized protocol for gene editing in adipocytes using CRISPR-Cas9 technology. Qiu Y, Ding Q. STAR Protoc. 2021 Jan 27;2(1):100307. doi: 10.1016/j.xpro.2021.100307. eCollection 2021 Mar 19. PubMed |
A pentameric protein ring with novel architecture is required for herpesviral packaging.
Didychuk AL, Gates SN, Gardner MR, Strong LM, Martin A, Glaunsinger BA.
Elife. 2021 Feb 8;10. pii: 62261. doi: 10.7554/eLife.62261.
PubMed
Associated Plasmids |
| SPRTN protease-cleaved MRE11 decreases DNA repair and radiosensitises cancer cells. Na J, Newman JA, Then CK, Syed J, Vendrell I, Torrecilla I, Ellermann S, Ramadan K, Fischer R, Kiltie AE. Cell Death Dis. 2021 Feb 8;12(2):165. doi: 10.1038/s41419-021-03437-w. PubMed |
| Identification of pannexin 1-regulated genes, interactome, and pathways in rhabdomyosarcoma and its tumor inhibitory interaction with AHNAK. Xiang X, Langlois S, St-Pierre ME, Blinder A, Charron P, Graber TE, Fowler SL, Baird SD, Bennett SAL, Alain T, Cowan KN. Oncogene. 2021 Mar;40(10):1868-1883. doi: 10.1038/s41388-020-01623-2. Epub 2021 Feb 9. PubMed |
| [Levels of sgRNA as a Major Factor Affecting CRISPRi Knockdown Efficiency in K562 Cells]. Wang Y, Xie Y, Dong ZC, Jiang XJ, Gong P, Lu J, Wan F. Mol Biol (Mosk). 2021 Jan-Feb;55(1):86-95. doi: 10.31857/S0026898421010146. PubMed |
| Spatial regulation of MCAK promotes cell polarization and focal adhesion turnover to drive robust cell migration. Zong H, Hazelbaker M, Moe C, Ems-McClung SC, Hu K, Walczak CE. Mol Biol Cell. 2021 Apr 1;32(7):590-604. doi: 10.1091/mbc.E20-05-0301. Epub 2021 Feb 10. PubMed |
| Gain-of-function p53 protein transferred via small extracellular vesicles promotes conversion of fibroblasts to a cancer-associated phenotype. Ma S, McGuire MH, Mangala LS, Lee S, Stur E, Hu W, Bayraktar E, Villar-Prados A, Ivan C, Wu SY, Yokoi A, Dasari SK, Jennings NB, Liu J, Lopez-Berestein G, Ram P, Sood AK. Cell Rep. 2021 Feb 9;34(6):108726. doi: 10.1016/j.celrep.2021.108726. PubMed |
| A conserved long noncoding RNA, GAPLINC, modulates the immune response during endotoxic shock. Vollmers AC, Covarrubias S, Kuang D, Shulkin A, Iwuagwu J, Katzman S, Song R, Viswanathan K, Vollmers C, Wakeland E, Carpenter S. Proc Natl Acad Sci U S A. 2021 Feb 16;118(7). pii: 2016648118. doi: 10.1073/pnas.2016648118. PubMed |
| LETR1 is a lymphatic endothelial-specific lncRNA governing cell proliferation and migration through KLF4 and SEMA3C. Ducoli L, Agrawal S, Sibler E, Kouno T, Tacconi C, Hon CC, Berger SD, Mullhaupt D, He Y, Kim J, D'Addio M, Dieterich LC, Carninci P, de Hoon MJL, Shin JW, Detmar M. Nat Commun. 2021 Feb 10;12(1):925. doi: 10.1038/s41467-021-21217-0. PubMed |
| Small molecule inhibitor of OGG1 blocks oxidative DNA damage repair at telomeres and potentiates methotrexate anticancer effects. Baquero JM, Benitez-Buelga C, Rajagopal V, Zhenjun Z, Torres-Ruiz R, Muller S, Hanna BMF, Loseva O, Wallner O, Michel M, Rodriguez-Perales S, Gad H, Visnes T, Helleday T, Benitez J, Osorio A. Sci Rep. 2021 Feb 10;11(1):3490. doi: 10.1038/s41598-021-82917-7. PubMed |
The Spike D614G mutation increases SARS-CoV-2 infection of multiple human cell types.
Daniloski Z, Jordan TX, Ilmain JK, Guo X, Bhabha G, tenOever BR, Sanjana NE.
Elife. 2021 Feb 11;10. pii: 65365. doi: 10.7554/eLife.65365.
PubMed
Associated Plasmids |
| Design of genetically encoded sensors to detect nucleosome ubiquitination in live cells. Dos Santos Passos C, Choi YS, Snow CD, Yao T, Cohen RE. J Cell Biol. 2021 Apr 5;220(4). pii: 211785. doi: 10.1083/jcb.201911130. PubMed |
| NOTCH1-driven UBR7 stimulates nucleotide biosynthesis to promote T cell acute lymphoblastic leukemia. Srivastava S, Sahu U, Zhou Y, Hogan AK, Sathyan KM, Bodner J, Huang J, Wong KA, Khalatyan N, Savas JN, Ntziachristos P, Ben-Sahra I, Foltz DR. Sci Adv. 2021 Jan 27;7(5). pii: 7/5/eabc9781. doi: 10.1126/sciadv.abc9781. Print 2021 Jan. PubMed |
| A synthetic mechanogenetic gene circuit for autonomous drug delivery in engineered tissues. Nims RJ, Pferdehirt L, Ho NB, Savadipour A, Lorentz J, Sohi S, Kassab J, Ross AK, O'Conor CJ, Liedtke WB, Zhang B, McNulty AL, Guilak F. Sci Adv. 2021 Jan 27;7(5). pii: 7/5/eabd9858. doi: 10.1126/sciadv.abd9858. Print 2021 Jan. PubMed |
| The IMiD target CRBN determines HSP90 activity toward transmembrane proteins essential in multiple myeloma. Heider M, Eichner R, Stroh J, Morath V, Kuisl A, Zecha J, Lawatscheck J, Baek K, Garz AK, Rudelius M, Deuschle FC, Keller U, Lemeer S, Verbeek M, Gotze KS, Skerra A, Weber WA, Buchner J, Schulman BA, Kuster B, Fernandez-Saiz V, Bassermann F. Mol Cell. 2021 Mar 18;81(6):1170-1186.e10. doi: 10.1016/j.molcel.2020.12.046. Epub 2021 Feb 10. PubMed |
| A genome-wide CRISPR screen identifies host factors that regulate SARS-CoV-2 entry. Zhu Y, Feng F, Hu G, Wang Y, Yu Y, Zhu Y, Xu W, Cai X, Sun Z, Han W, Ye R, Qu D, Ding Q, Huang X, Chen H, Xu W, Xie Y, Cai Q, Yuan Z, Zhang R. Nat Commun. 2021 Feb 11;12(1):961. doi: 10.1038/s41467-021-21213-4. PubMed |
| Two-component spike nanoparticle vaccine protects macaques from SARS-CoV-2 infection. Brouwer PJM, Brinkkemper M, Maisonnasse P, Dereuddre-Bosquet N, Grobben M, Claireaux M, de Gast M, Marlin R, Chesnais V, Diry S, Allen JD, Watanabe Y, Giezen JM, Kerster G, Turner HL, van der Straten K, van der Linden CA, Aldon Y, Naninck T, Bontjer I, Burger JA, Poniman M, Mykytyn AZ, Okba NMA, Schermer EE, van Breemen MJ, Ravichandran R, Caniels TG, van Schooten J, Kahlaoui N, Contreras V, Lemaitre J, Chapon C, Fang RHT, Villaudy J, Sliepen K, van der Velden YU, Haagmans BL, de Bree GJ, Ginoux E, Ward AB, Crispin M, King NP, van der Werf S, van Gils MJ, Le Grand R, Sanders RW. Cell. 2021 Mar 4;184(5):1188-1200.e19. doi: 10.1016/j.cell.2021.01.035. Epub 2021 Jan 26. PubMed |
The ubiquitin isopeptidase USP10 deubiquitinates LC3B to increase LC3B levels and autophagic activity.
Jia R, Bonifacino JS.
J Biol Chem. 2021 Jan-Jun;296:100405. doi: 10.1016/j.jbc.2021.100405. Epub 2021 Feb 10.
PubMed
Associated Plasmids |
| Signal peptidase complex subunit 1 is an essential Zika virus host factor in placental trophoblasts. Rother M, Naumann M. Virus Res. 2021 Apr 15;296:198338. doi: 10.1016/j.virusres.2021.198338. Epub 2021 Feb 9. PubMed |
| FGF8 and BMP2 mediated dynamic regulation of dental mesenchyme proliferation and differentiation via Lhx8/Suv39h1 complex. Zhou C, Chen D, Ren J, Huang D, Li R, Luo H, Guan C, Cao Y, Wang W. J Cell Mol Med. 2021 Mar;25(6):3051-3062. doi: 10.1111/jcmm.16351. Epub 2021 Feb 13. PubMed |
| Advanced single-cell pooled CRISPR screening identifies C19orf53 required for cell proliferation based on mTORC1 regulators. Tang Y, Liao S, Liu G, Xiong X, Liu H, Li F, Tan Z, Kong X, Yin Y, Tan B. Cell Biol Toxicol. 2021 Feb 13. pii: 10.1007/s10565-021-09586-0. doi: 10.1007/s10565-021-09586-0. PubMed |
| Lysophospholipid acylation modulates plasma membrane lipid organization and insulin sensitivity in skeletal muscle. Ferrara PJ, Rong X, Maschek JA, Verkerke AR, Siripoksup P, Song H, Green TD, Krishnan KC, Johnson JM, Turk J, Houmard JA, Lusis AJ, Drummond MJ, McClung JM, Cox JE, Shaikh SR, Tontonoz P, Holland WL, Funai K. J Clin Invest. 2021 Apr 15;131(8). pii: 135963. doi: 10.1172/JCI135963. PubMed |
| Centrosome amplification mediates small extracellular vesicle secretion via lysosome disruption. Adams SD, Csere J, D'angelo G, Carter EP, Romao M, Arnandis T, Dodel M, Kocher HM, Grose R, Raposo G, Mardakheh F, Godinho SA. Curr Biol. 2021 Apr 12;31(7):1403-1416.e7. doi: 10.1016/j.cub.2021.01.028. Epub 2021 Feb 15. PubMed |
| Modulating HSF1 levels impacts expression of the estrogen receptor alpha and antiestrogen response. Silveira MA, Tav C, Berube-Simard FA, Cuppens T, Leclercq M, Fournier E, Cote MC, Droit A, Bilodeau S. Life Sci Alliance. 2021 Feb 16;4(5). pii: 4/5/e202000811. doi: 10.26508/lsa.202000811. Print 2021 May. PubMed |
| Positioning of nucleosomes containing gamma-H2AX precedes active DNA demethylation and transcription initiation. Dobersch S, Rubio K, Singh I, Gunther S, Graumann J, Cordero J, Castillo-Negrete R, Huynh MB, Mehta A, Braubach P, Cabrera-Fuentes H, Bernhagen J, Chao CM, Bellusci S, Gunther A, Preissner KT, Kugel S, Dobreva G, Wygrecka M, Braun T, Papy-Garcia D, Barreto G. Nat Commun. 2021 Feb 16;12(1):1072. doi: 10.1038/s41467-021-21227-y. PubMed |
| Telomeres reforged with non-telomeric sequences in mouse embryonic stem cells. Kim C, Sung S, Kim JS, Lee H, Jung Y, Shin S, Kim E, Seo JJ, Kim J, Kim D, Niida H, Kim VN, Park D, Lee J. Nat Commun. 2021 Feb 17;12(1):1097. doi: 10.1038/s41467-021-21341-x. PubMed |
| The impact of episporic modification of Lichtheimia corymbifera on virulence and interaction with phagocytes. Hassan MIA, Keller M, Hillger M, Binder U, Reuter S, Herold K, Telagathoti A, Dahse HM, Wicht S, Trinks N, Nietzsche S, Deckert-Gaudig T, Deckert V, Mrowka R, Terpitz U, Peter Saluz H, Voigt K. Comput Struct Biotechnol J. 2021 Jan 20;19:880-896. doi: 10.1016/j.csbj.2021.01.023. eCollection 2021. PubMed |
| STIM2 Mediates Excessive Store-Operated Calcium Entry in Patient-Specific iPSC-Derived Neurons Modeling a Juvenile Form of Huntington's Disease. Vigont VA, Grekhnev DA, Lebedeva OS, Gusev KO, Volovikov EA, Skopin AY, Bogomazova AN, Shuvalova LD, Zubkova OA, Khomyakova EA, Glushankova LN, Klyushnikov SA, Illarioshkin SN, Lagarkova MA, Kaznacheyeva EV. Front Cell Dev Biol. 2021 Feb 2;9:625231. doi: 10.3389/fcell.2021.625231. eCollection 2021. PubMed |
| DGKA Mediates Resistance to PD-1 Blockade. Fu L, Li S, Xiao W, Yu K, Li S, Yuan S, Shen J, Dong X, Fang Z, Zhang J, Chen S, Li W, You H, Xia X, Kang T, Tan J, Chen G, Yang AK, Gao Y, Zhou P. Cancer Immunol Res. 2021 Apr;9(4):371-385. doi: 10.1158/2326-6066.CIR-20-0216. Epub 2021 Feb 19. PubMed |
| SARS-CoV-2 and SARS-CoV Spike-Mediated Cell-Cell Fusion Differ in Their Requirements for Receptor Expression and Proteolytic Activation. Hornich BF, Grosskopf AK, Schlagowski S, Tenbusch M, Kleine-Weber H, Neipel F, Stahl-Hennig C, Hahn AS. J Virol. 2021 Apr 12;95(9). pii: JVI.00002-21. doi: 10.1128/JVI.00002-21. Print 2021 Apr 12. PubMed |
| miR-130a activates the VEGFR2/STAT3/HIF1alpha axis to potentiate the vasoregenerative capacity of endothelial colony-forming cells in hypoxia. Guduric-Fuchs J, Pedrini E, Lechner J, Chambers SEJ, O'Neill CL, Mendes Lopes de Melo J, Pathak V, Church RH, McKeown S, Bojdo J, Mcloughlin KJ, Stitt AW, Medina RJ. Mol Ther Nucleic Acids. 2021 Jan 20;23:968-981. doi: 10.1016/j.omtn.2021.01.015. eCollection 2021 Mar 5. PubMed |
Adenine Base Editor Ribonucleoproteins Delivered by Lentivirus-Like Particles Show High On-Target Base Editing and Undetectable RNA Off-Target Activities.
Lyu P, Lu Z, Cho SI, Yadav M, Yoo KW, Atala A, Kim JS, Lu B.
CRISPR J. 2021 Feb;4(1):69-81. doi: 10.1089/crispr.2020.0095.
PubMed
Associated Plasmids |
| Differentiated glioblastoma cells accelerate tumor progression by shaping the tumor microenvironment via CCN1-mediated macrophage infiltration. Uneda A, Kurozumi K, Fujimura A, Fujii K, Ishida J, Shimazu Y, Otani Y, Tomita Y, Hattori Y, Matsumoto Y, Tsuboi N, Makino K, Hirano S, Kamiya A, Date I. Acta Neuropathol Commun. 2021 Feb 22;9(1):29. doi: 10.1186/s40478-021-01124-7. PubMed |
| Silencing of SRRM4 suppresses microexon inclusion and promotes tumor growth across cancers. Head SA, Hernandez-Alias X, Yang JS, Ciampi L, Beltran-Sastre V, Torres-Mendez A, Irimia M, Schaefer MH, Serrano L. PLoS Biol. 2021 Feb 23;19(2):e3001138. doi: 10.1371/journal.pbio.3001138. eCollection 2021 Feb. PubMed |
| SEC24A facilitates colocalization and Ca(2) (+) flux between the endoplasmic reticulum and mitochondria. Chidawanyika T, Chakrabarti R, Beauchemin KS, Higgs HN, Supattapone S. J Cell Sci. 2021 Mar 26;134(6). pii: jcs.249276. doi: 10.1242/jcs.249276. PubMed |
| Control of ribosomal protein synthesis by the Microprocessor complex. Jiang X, Prabhakar A, Van der Voorn SM, Ghatpande P, Celona B, Venkataramanan S, Calviello L, Lin C, Wang W, Black BL, Floor SN, Lagna G, Hata A. Sci Signal. 2021 Feb 23;14(671). pii: 14/671/eabd2639. doi: 10.1126/scisignal.abd2639. PubMed |
| Acquired cancer cell resistance to T cell bispecific antibodies and CAR T targeting HER2 through JAK2 down-modulation. Arenas EJ, Martinez-Sabadell A, Rius Ruiz I, Roman Alonso M, Escorihuela M, Luque A, Fajardo CA, Gros A, Klein C, Arribas J. Nat Commun. 2021 Feb 23;12(1):1237. doi: 10.1038/s41467-021-21445-4. PubMed |
| Targeting EphA2 suppresses hepatocellular carcinoma initiation and progression by dual inhibition of JAK1/STAT3 and AKT signaling. Wang H, Hou W, Perera A, Bettler C, Beach JR, Ding X, Li J, Denning MF, Dhanarajan A, Cotler SJ, Joyce C, Yin J, Ahmed F, Roberts LR, Qiu W. Cell Rep. 2021 Feb 23;34(8):108765. doi: 10.1016/j.celrep.2021.108765. PubMed |
| Accelerating target deconvolution for therapeutic antibody candidates using highly parallelized genome editing. Mattsson J, Ekdahl L, Junghus F, Ajore R, Erlandsson E, Niroula A, Pertesi M, Frendeus B, Teige I, Nilsson B. Nat Commun. 2021 Feb 24;12(1):1277. doi: 10.1038/s41467-021-21518-4. PubMed |
| Combinatorial CRISPR screen identifies fitness effects of gene paralogues. Thompson NA, Ranzani M, van der Weyden L, Iyer V, Offord V, Droop A, Behan F, Goncalves E, Speak A, Iorio F, Hewinson J, Harle V, Robertson H, Anderson E, Fu B, Yang F, Zagnoli-Vieira G, Chapman P, Del Castillo Velasco-Herrera M, Garnett MJ, Jackson SP, Adams DJ. Nat Commun. 2021 Feb 26;12(1):1302. doi: 10.1038/s41467-021-21478-9. PubMed |
| Distinct genetic pathways define pre-malignant versus compensatory clonal hematopoiesis in Shwachman-Diamond syndrome. Kennedy AL, Myers KC, Bowman J, Gibson CJ, Camarda ND, Furutani E, Muscato GM, Klein RH, Ballotti K, Liu S, Harris CE, Galvin A, Malsch M, Dale D, Gansner JM, Nakano TA, Bertuch A, Vlachos A, Lipton JM, Castillo P, Connelly J, Churpek J, Edwards JR, Hijiya N, Ho RH, Hofmann I, Huang JN, Keel S, Lamble A, Lau BW, Norkin M, Stieglitz E, Stock W, Walkovich K, Boettcher S, Brendel C, Fleming MD, Davies SM, Weller EA, Bahl C, Carter SL, Shimamura A, Lindsley RC. Nat Commun. 2021 Feb 26;12(1):1334. doi: 10.1038/s41467-021-21588-4. PubMed |
| Open-Label Study of the Influence of Food Containing the Royal Sun Mushroom, Agaricus brasiliensis KA21 (Agaricomycetes), on beta-Glucan-Specific Antibody Production in Healthy Human Volunteers. Yamanaka D, Shoda M, Matsubara T, Ishibashi KI, Motoi A, Motoi R, Motoi M, Ohno N, Adachi Y. Int J Med Mushrooms. 2021;23(2):13-28. doi: 10.1615/IntJMedMushrooms.2020037471. PubMed |
| The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals. Torrence ME, MacArthur MR, Hosios AM, Valvezan AJ, Asara JM, Mitchell JR, Manning BD. Elife. 2021 Mar 1;10. pii: 63326. doi: 10.7554/eLife.63326. PubMed |
| ASCL2 reciprocally controls key trophoblast lineage decisions during hemochorial placenta development. Varberg KM, Iqbal K, Muto M, Simon ME, Scott RL, Kozai K, Choudhury RH, Aplin JD, Biswell R, Gibson M, Okae H, Arima T, Vivian JL, Grundberg E, Soares MJ. Proc Natl Acad Sci U S A. 2021 Mar 9;118(10). pii: 2016517118. doi: 10.1073/pnas.2016517118. PubMed |
| ACE2 receptor usage reveals variation in susceptibility to SARS-CoV and SARS-CoV-2 infection among bat species. Yan H, Jiao H, Liu Q, Zhang Z, Xiong Q, Wang BJ, Wang X, Guo M, Wang LF, Lan K, Chen Y, Zhao H. Nat Ecol Evol. 2021 May;5(5):600-608. doi: 10.1038/s41559-021-01407-1. Epub 2021 Mar 1. PubMed |
| Plxdc family members are novel receptors for the rhesus monkey rhadinovirus (RRV). Grosskopf AK, Schlagowski S, Fricke T, Ensser A, Desrosiers RC, Hahn AS. PLoS Pathog. 2021 Mar 3;17(3):e1008979. doi: 10.1371/journal.ppat.1008979. eCollection 2021 Mar. PubMed |
| Exosomes from human cord blood plasma accelerate cutaneous wound healing by promoting fibroblast function, angiogenesis, and M2 macrophage differentiation. Kim S, Kim Y, Hyun YS, Choi H, Kim SY, Kim TG. Biomater Sci. 2021 Apr 21;9(8):3028-3039. doi: 10.1039/d0bm01801e. Epub 2021 Mar 3. PubMed |
| Post-transcriptional regulation of antiviral gene expression by N6-methyladenosine. McFadden MJ, McIntyre ABR, Mourelatos H, Abell NS, Gokhale NS, Ipas H, Xhemalce B, Mason CE, Horner SM. Cell Rep. 2021 Mar 2;34(9):108798. doi: 10.1016/j.celrep.2021.108798. PubMed |
| Novel Secreted Protein of Mycoplasma bovis MbovP280 Induces Macrophage Apoptosis Through CRYAB. Zhao G, Zhu X, Zhang H, Chen Y, Schieck E, Hu C, Chen H, Guo A. Front Immunol. 2021 Feb 15;12:619362. doi: 10.3389/fimmu.2021.619362. eCollection 2021. PubMed |
| Quantitative analysis of dense-core vesicle fusion in rodent CNS neurons. Moro A, Hoogstraaten RI, Persoon CM, Verhage M, Toonen RF. STAR Protoc. 2021 Feb 3;2(1):100325. doi: 10.1016/j.xpro.2021.100325. eCollection 2021 Mar 19. PubMed |
| Role of Clathrin Light Chains in Regulating Invadopodia Formation. Mukenhirn M, Muraca F, Bucher D, Asberger E, Cappio Barazzone E, Cavalcanti-Adam EA, Boulant S. Cells. 2021 Feb 20;10(2). pii: cells10020451. doi: 10.3390/cells10020451. PubMed |
| Epigenetic regulation of p62/SQSTM1 overcomes the radioresistance of head and neck cancer cells via autophagy-dependent senescence induction. Lee M, Nam HY, Kang HB, Lee WH, Lee GH, Sung GJ, Han MW, Cho KJ, Chang EJ, Choi KC, Kim SW, Kim SY. Cell Death Dis. 2021 Mar 5;12(3):250. doi: 10.1038/s41419-021-03539-5. PubMed |
| ARID1A knockdown in human endothelial cells directly induces angiogenesis by regulating angiopoietin-2 secretion and endothelial cell activity. Yoodee S, Peerapen P, Plumworasawat S, Thongboonkerd V. Int J Biol Macromol. 2021 Jun 1;180:1-13. doi: 10.1016/j.ijbiomac.2021.02.218. Epub 2021 Mar 3. PubMed |
| NGN2 mmRNA-Based Transcriptional Programming in Microfluidic Guides hiPSCs Toward Neural Fate With Multiple Identities. Tolomeo AM, Laterza C, Grespan E, Michielin F, Canals I, Kokaia Z, Muraca M, Gagliano O, Elvassore N. Front Cell Neurosci. 2021 Feb 12;15:602888. doi: 10.3389/fncel.2021.602888. eCollection 2021. PubMed |
| ORMDL3 Functions as a Negative Regulator of Antigen-Mediated Mast Cell Activation via an ATF6-UPR-Autophagy-Dependent Pathway. Li J, Ullah MA, Jin H, Liang Y, Lin L, Wang J, Peng X, Liao H, Li Y, Ge Y, Li L. Front Immunol. 2021 Feb 19;12:604974. doi: 10.3389/fimmu.2021.604974. eCollection 2021. PubMed |
| JMJD6 negatively regulates cytosolic RNA induced antiviral signaling by recruiting RNF5 to promote activated IRF3 K48 ubiquitination. Zhang W, Wang Q, Yang F, Zhu Z, Duan Y, Yang Y, Cao W, Zhang K, Ma J, Liu X, Zheng H. PLoS Pathog. 2021 Mar 8;17(3):e1009366. doi: 10.1371/journal.ppat.1009366. eCollection 2021 Mar. PubMed |
| C11orf95-RELA fusion drives aberrant gene expression through the unique epigenetic regulation for ependymoma formation. Ozawa T, Kaneko S, Szulzewsky F, Qiao Z, Takadera M, Narita Y, Kondo T, Holland EC, Hamamoto R, Ichimura K. Acta Neuropathol Commun. 2021 Mar 8;9(1):36. doi: 10.1186/s40478-021-01135-4. PubMed |
| Lin28 Inhibits the Differentiation from Mouse Embryonic Stem Cells to Glial Lineage Cells through Upregulation of Yap1. Luo J, Zou H, Deng L, Sun X, Yuan P, Li P. Stem Cells Int. 2021 Feb 22;2021:6674283. doi: 10.1155/2021/6674283. eCollection 2021. PubMed |
| Biofabrication of a three dimensional human-based personalized neurofibroma model. Roy V, Lamontagne R, Talagas M, Touzel-Deschenes L, Khuong HT, Saikali S, Dupre N, Gros-Louis F. Biotechnol J. 2021 Jun;16(6):e2000250. doi: 10.1002/biot.202000250. Epub 2021 Apr 7. PubMed |
| Identification of pathogenic variants in cancer genes using base editing screens with editing efficiency correction. Huang C, Li G, Wu J, Liang J, Wang X. Genome Biol. 2021 Mar 10;22(1):80. doi: 10.1186/s13059-021-02305-2. PubMed |
| SIRT3 consolidates heterochromatin and counteracts senescence. Diao Z, Ji Q, Wu Z, Zhang W, Cai Y, Wang Z, Hu J, Liu Z, Wang Q, Bi S, Huang D, Ji Z, Liu GH, Wang S, Song M, Qu J. Nucleic Acids Res. 2021 May 7;49(8):4203-4219. doi: 10.1093/nar/gkab161. PubMed |
| A novel cell culture system modeling the SARS-CoV-2 life cycle. Ju X, Zhu Y, Wang Y, Li J, Zhang J, Gong M, Ren W, Li S, Zhong J, Zhang L, Zhang QC, Zhang R, Ding Q. PLoS Pathog. 2021 Mar 12;17(3):e1009439. doi: 10.1371/journal.ppat.1009439. eCollection 2021 Mar. PubMed |
| Creb5 establishes the competence for Prg4 expression in articular cartilage. Zhang CH, Gao Y, Jadhav U, Hung HH, Holton KM, Grodzinsky AJ, Shivdasani RA, Lassar AB. Commun Biol. 2021 Mar 12;4(1):332. doi: 10.1038/s42003-021-01857-0. PubMed |
| FLI1 Induces Megakaryopoiesis Gene Expression Through WAS/WIP-Dependent and Independent Mechanisms; Implications for Wiskott-Aldrich Syndrome. Wang C, Sample KM, Gajendran B, Kapranov P, Liu W, Hu A, Zacksenhaus E, Li Y, Hao X, Ben-David Y. Front Immunol. 2021 Feb 26;12:607836. doi: 10.3389/fimmu.2021.607836. eCollection 2021. PubMed |
| Pin1 Promotes NLRP3 Inflammasome Activation by Phosphorylation of p38 MAPK Pathway in Septic Shock. Dong R, Xue Z, Fan G, Zhang N, Wang C, Li G, Da Y. Front Immunol. 2021 Feb 25;12:620238. doi: 10.3389/fimmu.2021.620238. eCollection 2021. PubMed |
| The Crucial Role of PPARgamma-Egr-1-Pro-Inflammatory Mediators Axis in IgG Immune Complex-Induced Acute Lung Injury. Yan C, Chen J, Ding Y, Zhou Z, Li B, Deng C, Yuan D, Zhang Q, Wang X. Front Immunol. 2021 Feb 25;12:634889. doi: 10.3389/fimmu.2021.634889. eCollection 2021. PubMed |
| Sall4 and Myocd Empower Direct Cardiac Reprogramming From Adult Cardiac Fibroblasts After Injury. Zhao H, Zhang Y, Xu X, Sun Q, Yang C, Wang H, Yang J, Yang Y, Yang X, Liu Y, Zhao Y. Front Cell Dev Biol. 2021 Feb 26;9:608367. doi: 10.3389/fcell.2021.608367. eCollection 2021. PubMed |
| Effective, safe, and sustained correction of murine XLA using a UCOE-BTK promoter-based lentiviral vector. Seymour BJ, Singh S, Certo HM, Sommer K, Sather BD, Khim S, Clough C, Hale M, Pangallo J, Ryu BY, Khan IF, Adair JE, Rawlings DJ. Mol Ther Methods Clin Dev. 2021 Jan 20;20:635-651. doi: 10.1016/j.omtm.2021.01.007. eCollection 2021 Mar 12. PubMed |
| Engineering T Cells to Express Tumoricidal MDA-7/IL24 Enhances Cancer Immunotherapy. Liu Z, Guo C, Das SK, Yu X, Pradhan AK, Li X, Ning Y, Chen S, Liu W, Windle JJ, Bear HD, Manjili MH, Fisher PB, Wang XY. Cancer Res. 2021 May 1;81(9):2429-2441. doi: 10.1158/0008-5472.CAN-20-2604. Epub 2021 Mar 16. PubMed |
| RNA decay in processing bodies is indispensable for adipogenesis. Maeda R, Kami D, Shikuma A, Suzuki Y, Taya T, Matoba S, Gojo S. Cell Death Dis. 2021 Mar 17;12(4):285. doi: 10.1038/s41419-021-03537-7. PubMed |
Lentiviral Capsid-Mediated Streptococcus pyogenes Cas9 Ribonucleoprotein Delivery for Efficient and Safe Multiplex Genome Editing.
Lu Z, Yao X, Lyu P, Yadav M, Yoo K, Atala A, Lu B.
CRISPR J. 2021 Mar 16. doi: 10.1089/crispr.2020.0106.
PubMed
Associated Plasmids |
| CRISPRi screens reveal a DNA methylation-mediated 3D genome dependent causal mechanism in prostate cancer. Ahmed M, Soares F, Xia JH, Yang Y, Li J, Guo H, Su P, Tian Y, Lee HJ, Wang M, Akhtar N, Houlahan KE, Bosch A, Zhou S, Mazrooei P, Hua JT, Chen S, Petricca J, Zeng Y, Davies A, Fraser M, Quigley DA, Feng FY, Boutros PC, Lupien M, Zoubeidi A, Wang L, Walsh MJ, Wang T, Ren S, Wei GH, He HH. Nat Commun. 2021 Mar 19;12(1):1781. doi: 10.1038/s41467-021-21867-0. PubMed |
Engineered extracellular vesicles as versatile ribonucleoprotein delivery vehicles for efficient and safe CRISPR genome editing.
Yao X, Lyu P, Yoo K, Yadav MK, Singh R, Atala A, Lu B.
J Extracell Vesicles. 2021 Mar;10(5):e12076. doi: 10.1002/jev2.12076. Epub 2021 Mar 16.
PubMed
Associated Plasmids |
| A hierarchical regulatory network analysis of the vitamin D induced transcriptome reveals novel regulators and complete VDR dependency in monocytes. Warwick T, Schulz MH, Gunther S, Gilsbach R, Neme A, Carlberg C, Brandes RP, Seuter S. Sci Rep. 2021 Mar 22;11(1):6518. doi: 10.1038/s41598-021-86032-5. PubMed |
| TMEM16F mediates bystander TCR-CD3 membrane dissociation at the immunological synapse and potentiates T cell activation. Connolly A, Panes R, Tual M, Lafortune R, Bellemare-Pelletier A, Gagnon E. Sci Signal. 2021 Mar 23;14(675). pii: 14/675/eabb5146. doi: 10.1126/scisignal.abb5146. PubMed |
| Mutant ASXL1 induces age-related expansion of phenotypic hematopoietic stem cells through activation of Akt/mTOR pathway. Fujino T, Goyama S, Sugiura Y, Inoue D, Asada S, Yamasaki S, Matsumoto A, Yamaguchi K, Isobe Y, Tsuchiya A, Shikata S, Sato N, Morinaga H, Fukuyama T, Tanaka Y, Fukushima T, Takeda R, Yamamoto K, Honda H, Nishimura EK, Furukawa Y, Shibata T, Abdel-Wahab O, Suematsu M, Kitamura T. Nat Commun. 2021 Mar 23;12(1):1826. doi: 10.1038/s41467-021-22053-y. PubMed |
| Comparative analysis reveals the species-specific genetic determinants of ACE2 required for SARS-CoV-2 entry. Ren W, Zhu Y, Wang Y, Shi H, Yu Y, Hu G, Feng F, Zhao X, Lan J, Wu J, Kenney DJ, Douam F, Tong Y, Zhong J, Xie Y, Wang X, Yuan Z, Zhou D, Zhang R, Ding Q. PLoS Pathog. 2021 Mar 24;17(3):e1009392. doi: 10.1371/journal.ppat.1009392. eCollection 2021 Mar. PubMed |
| SH3BP4 promotes neuropilin-1 and alpha5-integrin endocytosis and is inhibited by Akt. Burckhardt CJ, Minna JD, Danuser G. Dev Cell. 2021 Apr 19;56(8):1164-1181.e12. doi: 10.1016/j.devcel.2021.03.009. Epub 2021 Mar 23. PubMed |
| HIF1alpha/HIF2alpha-Sox2/Klf4 promotes the malignant progression of glioblastoma via the EGFR-PI3K/AKT signalling pathway with positive feedback under hypoxia. Wang P, Zhao L, Gong S, Xiong S, Wang J, Zou D, Pan J, Deng Y, Yan Q, Wu N, Liao B. Cell Death Dis. 2021 Mar 24;12(4):312. doi: 10.1038/s41419-021-03598-8. PubMed |
WWTR1(TAZ)-CAMTA1 reprograms endothelial cells to drive epithelioid hemangioendothelioma.
Driskill JH, Zheng Y, Wu BK, Wang L, Cai J, Rakheja D, Dellinger M, Pan D.
Genes Dev. 2021 Apr 1;35(7-8):495-511. doi: 10.1101/gad.348221.120. Epub 2021 Mar 25.
PubMed
Associated Plasmids |
| A genome-scale CRISPR Cas9 dropout screen identifies synthetically lethal targets in SRC-3 inhibited cancer cells. Gilad Y, Eliaz Y, Yu Y, Dean AM, Han SJ, Qin L, O'Malley BW, Lonard DM. Commun Biol. 2021 Mar 25;4(1):399. doi: 10.1038/s42003-021-01929-1. PubMed |
| The tumor suppressor kinase DAPK3 drives tumor-intrinsic immunity through the STING-IFN-beta pathway. Takahashi M, Lio CJ, Campeau A, Steger M, Ay F, Mann M, Gonzalez DJ, Jain M, Sharma S. Nat Immunol. 2021 Apr;22(4):485-496. doi: 10.1038/s41590-021-00896-3. Epub 2021 Mar 25. PubMed |
| FEZ1 Forms Complexes with CRMP1 and DCC to Regulate Axon and Dendrite Development. Chua JY, Ng SJ, Yagensky O, Wanker EE, Chua JJE. eNeuro. 2021 Apr 16;8(2). pii: ENEURO.0193-20.2021. doi: 10.1523/ENEURO.0193-20.2021. Print 2021 Mar-Apr. PubMed |
| MED15 prion-like domain forms a coiled-coil responsible for its amyloid conversion and propagation. Batlle C, Calvo I, Iglesias V, J Lynch C, Gil-Garcia M, Serrano M, Ventura S. Commun Biol. 2021 Mar 26;4(1):414. doi: 10.1038/s42003-021-01930-8. PubMed |
| USP22 promotes melanoma and BRAF inhibitor resistance via YAP stabilization. Wei Y, Jiang Z, Lu J. Oncol Lett. 2021 May;21(5):394. doi: 10.3892/ol.2021.12655. Epub 2021 Mar 18. PubMed |
| A Role for Polo-Like Kinase 4 in Vascular Fibroblast Cell-Type Transition. Li J, Urabe G, Huang Y, Zhang M, Wang B, Marcho L, Shen H, Kent KC, Guo LW. JACC Basic Transl Sci. 2021 Mar 22;6(3):257-283. doi: 10.1016/j.jacbts.2020.12.015. eCollection 2021 Mar. PubMed |
| Sensitivity of cells to ATR and CHK1 inhibitors requires hyperactivation of CDK2 rather than endogenous replication stress or ATM dysfunction. Ditano JP, Donahue KL, Tafe LJ, McCleery CF, Eastman A. Sci Rep. 2021 Mar 29;11(1):7077. doi: 10.1038/s41598-021-86490-x. PubMed |
| A modified parachute assay for assessment of gap junction intercellular communication in placental trophoblast cells. Gingrich J, Pu Y, Veiga-Lopez A. Toxicol Mech Methods. 2021 Jun;31(5):393-399. doi: 10.1080/15376516.2021.1904072. Epub 2021 Mar 30. PubMed |
| RANK signaling increases after anti-HER2 therapy contributing to the emergence of resistance in HER2-positive breast cancer. Sanz-Moreno A, Palomeras S, Pedersen K, Morancho B, Pascual T, Galvan P, Benitez S, Gomez-Miragaya J, Ciscar M, Jimenez M, Pernas S, Petit A, Soler-Monso MT, Vinas G, Alsaleem M, Rakha EA, Green AR, Santamaria PG, Mulder C, Lemeer S, Arribas J, Prat A, Puig T, Gonzalez-Suarez E. Breast Cancer Res. 2021 Mar 30;23(1):42. doi: 10.1186/s13058-021-01390-2. PubMed |
| RIPK2 is an unfavorable prognosis marker and a potential therapeutic target in human kidney renal clear cell carcinoma. Li D, Tang L, Liu B, Xu S, Jin M, Bo W. Aging (Albany NY). 2021 Mar 31;13(7):10450-10467. doi: 10.18632/aging.202808. Epub 2021 Mar 31. PubMed |
| Control of endothelial quiescence by FOXO-regulated metabolites. Andrade J, Shi C, Costa ASH, Choi J, Kim J, Doddaballapur A, Sugino T, Ong YT, Castro M, Zimmermann B, Kaulich M, Guenther S, Wilhelm K, Kubota Y, Braun T, Koh GY, Grosso AR, Frezza C, Potente M. Nat Cell Biol. 2021 Apr;23(4):413-423. doi: 10.1038/s41556-021-00637-6. Epub 2021 Apr 1. PubMed |
| m(6)A-independent genome-wide METTL3 and METTL14 redistribution drives the senescence-associated secretory phenotype. Liu P, Li F, Lin J, Fukumoto T, Nacarelli T, Hao X, Kossenkov AV, Simon MC, Zhang R. Nat Cell Biol. 2021 Apr;23(4):355-365. doi: 10.1038/s41556-021-00656-3. Epub 2021 Apr 1. PubMed |
| Generation and Implementation of Reporter BHK-21 Cells for Live Imaging of Flavivirus Infection. Arias-Arias JL, Mora-Rodriguez R. Bio Protoc. 2021 Mar 5;11(5):e3942. doi: 10.21769/BioProtoc.3942. eCollection 2021 Mar 5. PubMed |
| Direct Generation of Immortalized Erythroid Progenitor Cell Lines from Peripheral Blood Mononuclear Cells. Bagchi A, Nath A, Thamodaran V, Ijee S, Palani D, Rajendiran V, Venkatesan V, Datari P, Pai AA, Janet NB, Balasubramanian P, Nakamura Y, Srivastava A, Mohankumar KM, Thangavel S, Velayudhan SR. Cells. 2021 Mar 1;10(3). pii: cells10030523. doi: 10.3390/cells10030523. PubMed |
| HIF-1alpha and Pro-Inflammatory Signaling Improves the Immunomodulatory Activity of MSC-Derived Extracellular Vesicles. Gomez-Ferrer M, Villanueva-Badenas E, Sanchez-Sanchez R, Sanchez-Lopez CM, Baquero MC, Sepulveda P, Dorronsoro A. Int J Mol Sci. 2021 Mar 26;22(7). pii: ijms22073416. doi: 10.3390/ijms22073416. PubMed |
| YTHDF1 Aggravates the Progression of Cervical Cancer Through m(6)A-Mediated Up-Regulation of RANBP2. Wang H, Luo Q, Kang J, Wei Q, Yang Y, Yang D, Liu X, Liu T, Yi P. Front Oncol. 2021 Mar 19;11:650383. doi: 10.3389/fonc.2021.650383. eCollection 2021. PubMed |
| Establishment and characterization of an immortalized epicardial cell line. Jiang H, Song S, Li J, Yin Q, Hu S, Nie Y. J Cell Mol Med. 2021 Apr 6. doi: 10.1111/jcmm.16496. PubMed |
| Gene Editing in Human Induced Pluripotent Stem Cells Using Doxycycline-Inducible CRISPR-Cas9 System. Thamodaran V, Rani S, Velayudhan SR. Methods Mol Biol. 2021 Apr 9. doi: 10.1007/7651_2021_348. PubMed |
| Therapeutic targeting of FOS in mutant TERT cancers through removing TERT suppression of apoptosis via regulating survivin and TRAIL-R2. Liu R, Tan J, Shen X, Jiang K, Wang C, Zhu G, Xing M. Proc Natl Acad Sci U S A. 2021 Mar 16;118(11):e2022779118. doi: 10.1073/pnas.2022779118. PubMed |
| Disruption of the MSL complex inhibits tumour maintenance by exacerbating chromosomal instability. Monserrat J, Morales Torres C, Richardson L, Wilson TS, Patel H, Domart MC, Horswell S, Song OR, Jiang M, Crawford M, Bui M, Dalal Y, Scaffidi P. Nat Cell Biol. 2021 Apr;23(4):401-412. doi: 10.1038/s41556-021-00657-2. Epub 2021 Apr 9. PubMed |
| Directed Evolution of Stabilized Monomeric CD19 for Monovalent CAR Interaction Studies and Monitoring of CAR-T Cell Patients. Laurent E, Sieber A, Salzer B, Wachernig A, Seigner J, Lehner M, Geyeregger R, Kratzer B, Jager U, Kunert R, Pickl WF, Traxlmayr MW. ACS Synth Biol. 2021 May 21;10(5):1184-1198. doi: 10.1021/acssynbio.1c00010. Epub 2021 Apr 12. PubMed |
| Genome-wide screens uncover KDM2B as a modifier of protein binding to heparan sulfate. Weiss RJ, Spahn PN, Chiang AWT, Liu Q, Li J, Hamill KM, Rother S, Clausen TM, Hoeksema MA, Timm BM, Godula K, Glass CK, Tor Y, Gordts PLSM, Lewis NE, Esko JD. Nat Chem Biol. 2021 Jun;17(6):684-692. doi: 10.1038/s41589-021-00776-9. Epub 2021 Apr 12. PubMed |
| SARS-CoV-2 ORF6 Disrupts Bidirectional Nucleocytoplasmic Transport through Interactions with Rae1 and Nup98. Addetia A, Lieberman NAP, Phung Q, Hsiang TY, Xie H, Roychoudhury P, Shrestha L, Loprieno MA, Huang ML, Gale M Jr, Jerome KR, Greninger AL. mBio. 2021 Apr 13;12(2). pii: mBio.00065-21. doi: 10.1128/mBio.00065-21. PubMed |
| Engrailed-2 is a cell autonomous regulator of neurogenesis in cultured hippocampal neural stem cells. Durens M, Soliman M, Millonig J, DiCicco-Bloom E. Dev Neurobiol. 2021 Jul;81(5):724-735. doi: 10.1002/dneu.22824. Epub 2021 May 5. PubMed |
| A nonviral, nonintegrating DNA nanovector platform for the safe, rapid, and persistent manufacture of recombinant T cells. Bozza M, De Roia A, Correia MP, Berger A, Tuch A, Schmidt A, Zornig I, Jager D, Schmidt P, Harbottle RP. Sci Adv. 2021 Apr 14;7(16). pii: 7/16/eabf1333. doi: 10.1126/sciadv.abf1333. Print 2021 Apr. PubMed |
| Deficiency of Ku Induces Host Cell Exploitation in Human Cancer Cells. Saydam O, Saydam N. Front Cell Dev Biol. 2021 Mar 29;9:651818. doi: 10.3389/fcell.2021.651818. eCollection 2021. PubMed |
| SOD1 regulates ribosome biogenesis in KRAS mutant non-small cell lung cancer. Wang X, Zhang H, Sapio R, Yang J, Wong J, Zhang X, Guo JY, Pine S, Van Remmen H, Li H, White E, Liu C, Kiledjian M, Pestov DG, Steven Zheng XF. Nat Commun. 2021 Apr 15;12(1):2259. doi: 10.1038/s41467-021-22480-x. PubMed |
| Genome wide CRISPR screening reveals a role for sialylation in the tumorigenesis and chemoresistance of acute myeloid leukemia cells. Lee DH, Kang SH, Choi DS, Ko M, Choi E, Ahn H, Min H, Oh SJ, Lee MS, Park Y, Jin HS. Cancer Lett. 2021 Jul 10;510:37-47. doi: 10.1016/j.canlet.2021.04.006. Epub 2021 Apr 16. PubMed |
| Targeting Triple-Negative Breast Cancer with Combination Therapy of EGFR CAR T Cells and CDK7 Inhibition. Xia L, Zheng Z, Liu JY, Chen YJ, Ding J, Hu GS, Hu YH, Liu S, Luo WX, Xia NS, Liu W. Cancer Immunol Res. 2021 Jun;9(6):707-722. doi: 10.1158/2326-6066.CIR-20-0405. Epub 2021 Apr 19. PubMed |
| STING enhances cell death through regulation of reactive oxygen species and DNA damage. Hayman TJ, Baro M, MacNeil T, Phoomak C, Aung TN, Cui W, Leach K, Iyer R, Challa S, Sandoval-Schaefer T, Burtness BA, Rimm DL, Contessa JN. Nat Commun. 2021 Apr 19;12(1):2327. doi: 10.1038/s41467-021-22572-8. PubMed |
| PD-L1 tumor-intrinsic signaling and its therapeutic implication in triple-negative breast cancer. Chen C, Li S, Xue J, Qi M, Liu X, Huang Y, Hu J, Dong H, Ling K. JCI Insight. 2021 Apr 22;6(8). pii: 131458. doi: 10.1172/jci.insight.131458. PubMed |
| A BLOC-1-AP-3 super-complex sorts a cis-SNARE complex into endosome-derived tubular transport carriers. Bowman SL, Le L, Zhu Y, Harper DC, Sitaram A, Theos AC, Sviderskaya EV, Bennett DC, Raposo-Benedetti G, Owen DJ, Dennis MK, Marks MS. J Cell Biol. 2021 Jul 5;220(7). pii: 212016. doi: 10.1083/jcb.202005173. PubMed |
| BRD4 PROTAC degrader ARV-825 inhibits T-cell acute lymphoblastic leukemia by targeting 'Undruggable' Myc-pathway genes. Wu S, Jiang Y, Hong Y, Chu X, Zhang Z, Tao Y, Fan Z, Bai Z, Li X, Chen Y, Li Z, Ding X, Lv H, Du X, Lim SL, Zhang Y, Huang S, Lu J, Pan J, Hu S. Cancer Cell Int. 2021 Apr 22;21(1):230. doi: 10.1186/s12935-021-01908-w. PubMed |
| BRCA1 degradation in response to mitochondrial damage in breast cancer cells. Miyahara K, Takano N, Yamada Y, Kazama H, Tokuhisa M, Hino H, Fujita K, Barroga E, Hiramoto M, Handa H, Kuroda M, Ishikawa T, Miyazawa K. Sci Rep. 2021 Apr 22;11(1):8735. doi: 10.1038/s41598-021-87698-7. PubMed |
Co-regulation and function of FOXM1/RHNO1 bidirectional genes in cancer.
Barger CJ, Chee L, Albahrani M, Munoz-Trujillo C, Boghean L, Branick C, Odunsi K, Drapkin R, Zou L, Karpf AR.
Elife. 2021 Apr 23;10. pii: 55070. doi: 10.7554/eLife.55070.
PubMed
Associated Plasmids |
| CRISPR-based genome editing in primary human pancreatic islet cells. Bevacqua RJ, Dai X, Lam JY, Gu X, Friedlander MSH, Tellez K, Miguel-Escalada I, Bonas-Guarch S, Atla G, Zhao W, Kim SH, Dominguez AA, Qi LS, Ferrer J, MacDonald PE, Kim SK. Nat Commun. 2021 Apr 23;12(1):2397. doi: 10.1038/s41467-021-22651-w. PubMed |
| Gsx1 promotes locomotor functional recovery after spinal cord injury. Patel M, Li Y, Anderson J, Castro-Pedrido S, Skinner R, Lei S, Finkel Z, Rodriguez B, Esteban F, Lee KB, Lyu YL, Cai L. Mol Ther. 2021 Aug 4;29(8):2469-2482. doi: 10.1016/j.ymthe.2021.04.027. Epub 2021 Apr 23. PubMed |
| OTUD1 Activates Caspase-Independent and Caspase-Dependent Apoptosis by Promoting AIF Nuclear Translocation and MCL1 Degradation. Luo Q, Wu X, Zhao P, Nan Y, Chang W, Zhu X, Su D, Liu Z. Adv Sci (Weinh). 2021 Feb 8;8(8):2002874. doi: 10.1002/advs.202002874. eCollection 2021 Apr. PubMed |
| Pooled CRISPR-activation screening coupled with single-cell RNA-seq in mouse embryonic stem cells. Alda-Catalinas C, Eckersley-Maslin MA, Reik W. STAR Protoc. 2021 Apr 9;2(2):100426. doi: 10.1016/j.xpro.2021.100426. eCollection 2021 Jun 18. PubMed |
| Caspase-9 acts as a regulator of necroptotic cell death. Molnar T, Pallagi P, Tel B, Kiraly R, Csoma E, Jenei V, Varga Z, Gogolak P, Odile Hueber A, Mate Z, Erdelyi F, Szabo G, Pettko-Szandtner A, Bacsi A, Virag L, Maleth J, Koncz G. FEBS J. 2021 Apr 25. doi: 10.1111/febs.15898. PubMed |
| Colonic epithelial adaptation to EGFR-independent growth induces chromosomal instability and is accelerated by prior injury. Chen T, Zeineldin M, Johnson BA, Dong Y, Narkar A, Li T, Zhu J, Li R, Larman TC. Neoplasia. 2021 May;23(5):488-501. doi: 10.1016/j.neo.2021.03.010. Epub 2021 Apr 24. PubMed |
| PTEN is a predictive biomarker of trastuzumab resistance and prognostic factor in HER2-overexpressing gastroesophageal adenocarcinoma. Yokoyama D, Hisamori S, Deguchi Y, Nishigori T, Okabe H, Kanaya S, Manaka D, Kadokawa Y, Hata H, Minamiguchi S, Tsunoda S, Obama K, Sakai Y. Sci Rep. 2021 Apr 27;11(1):9013. doi: 10.1038/s41598-021-88331-3. PubMed |
| Inhibition of mitochondrial translation suppresses glioblastoma stem cell growth. Sighel D, Notarangelo M, Aibara S, Re A, Ricci G, Guida M, Soldano A, Adami V, Ambrosini C, Broso F, Rosatti EF, Longhi S, Buccarelli M, D'Alessandris QG, Giannetti S, Pacioni S, Ricci-Vitiani L, Rorbach J, Pallini R, Roulland S, Amunts A, Mancini I, Modelska A, Quattrone A. Cell Rep. 2021 Apr 27;35(4):109024. doi: 10.1016/j.celrep.2021.109024. PubMed |
| PDZD8-mediated lipid transfer at contacts between the ER and late endosomes/lysosomes is required for neurite outgrowth. Gao Y, Xiong J, Chu QZ, Ji WK. J Cell Sci. 2022 Mar 1;135(5). pii: 256568. doi: 10.1242/jcs.255026. Epub 2021 Apr 20. PubMed |
| Caspase inhibition prolongs inflammation by promoting a signaling complex with activated RIPK1. Huang X, Tan S, Li Y, Cao S, Li X, Pan H, Shan B, Qian L, Yuan J. J Cell Biol. 2021 Jun 7;220(6). pii: 212035. doi: 10.1083/jcb.202007127. PubMed |
| Interpretative differences of combined cytogenetic and molecular profiling highlights differences between MRC and ELN classifications of AML. Sussman RT, Manning B, Ackerman D, Bigdeli A, Pammer P, Velu PD, Luger SM, Bagg A, Carroll M, Morrissette JJD. Cancer Genet. 2021 Aug;256-257:68-76. doi: 10.1016/j.cancergen.2021.04.004. Epub 2021 Apr 16. PubMed |
| Role of Decorin in Posterior Capsule Opacification and Eye Lens Development. Shibata S, Shibata N, Ohtsuka S, Yoshitomi Y, Kiyokawa E, Yonekura H, Singh DP, Sasaki H, Kubo E. Cells. 2021 Apr 9;10(4). pii: cells10040863. doi: 10.3390/cells10040863. PubMed |
| Selection, Expansion, and Unique Pretreatment of Allogeneic Human Natural Killer Cells with Anti-CD38 Monoclonal Antibody for Efficient Multiple Myeloma Treatment. Motais B, Charvatova S, Walek Z, Hrdinka M, Smolarczyk R, Cichon T, Czapla J, Giebel S, Simicek M, Jelinek T, Sevcikova T, Sobotka J, Koristek Z, Hajek R, Bago JR. Cells. 2021 Apr 21;10(5). pii: cells10050967. doi: 10.3390/cells10050967. PubMed |
| hTERT Downregulation Attenuates Resistance to DOX, Impairs FAK-Mediated Adhesion, and Leads to Autophagy Induction in Breast Cancer Cells. Romaniuk-Drapala A, Toton E, Konieczna N, Machnik M, Barczak W, Kowal D, Kopczynski P, Kaczmarek M, Rubis B. Cells. 2021 Apr 10;10(4). pii: cells10040867. doi: 10.3390/cells10040867. PubMed |
| Combination of Talazoparib and Palbociclib as a Potent Treatment Strategy in Bladder Cancer. Klein FG, Granier C, Zhao Y, Pan Q, Tong Z, Gschwend JE, Holm PS, Nawroth R. J Pers Med. 2021 Apr 24;11(5). pii: jpm11050340. doi: 10.3390/jpm11050340. PubMed |
| Live-Cell Analysis of Human Cytomegalovirus DNA Polymerase Holoenzyme Assembly by Resonance Energy Transfer Methods. Di Antonio V, Palu G, Alvisi G. Microorganisms. 2021 Apr 26;9(5). pii: microorganisms9050928. doi: 10.3390/microorganisms9050928. PubMed |
Profiling the genetic determinants of chromatin accessibility with scalable single-cell CRISPR screens.
Liscovitch-Brauer N, Montalbano A, Deng J, Mendez-Mancilla A, Wessels HH, Moss NG, Kung CY, Sookdeo A, Guo X, Geller E, Jaini S, Smibert P, Sanjana NE.
Nat Biotechnol. 2021 Apr 29. pii: 10.1038/s41587-021-00902-x. doi: 10.1038/s41587-021-00902-x.
PubMed
Associated Plasmids |
| Functional landscape of SARS-CoV-2 cellular restriction. Martin-Sancho L, Lewinski MK, Pache L, Stoneham CA, Yin X, Becker ME, Pratt D, Churas C, Rosenthal SB, Liu S, Weston S, De Jesus PD, O'Neill AM, Gounder AP, Nguyen C, Pu Y, Curry HM, Oom AL, Miorin L, Rodriguez-Frandsen A, Zheng F, Wu C, Xiong Y, Urbanowski M, Shaw ML, Chang MW, Benner C, Hope TJ, Frieman MB, Garcia-Sastre A, Ideker T, Hultquist JF, Guatelli J, Chanda SK. Mol Cell. 2021 Jun 17;81(12):2656-2668.e8. doi: 10.1016/j.molcel.2021.04.008. Epub 2021 Apr 13. PubMed |
| Cut-like homeobox 1 (CUX1) tumor suppressor gene haploinsufficiency induces apoptosis evasion to sustain myeloid leukemia. Supper E, Rudat S, Iyer V, Droop A, Wong K, Spinella JF, Thomas P, Sauvageau G, Adams DJ, Wong CC. Nat Commun. 2021 Apr 30;12(1):2482. doi: 10.1038/s41467-021-22750-8. PubMed |
| Multiple interactions of the oncoprotein transcription factor MYC with the SWI/SNF chromatin remodeler. Woodley CM, Romer AS, Wang J, Guarnaccia AD, Elion DL, Maxwell JN, Guerrazzi K, McCann TS, Popay TM, Matlock BK, Flaherty DK, Lorey SL, Liu Q, Tansey WP, Weissmiller AM. Oncogene. 2021 May;40(20):3593-3609. doi: 10.1038/s41388-021-01804-7. Epub 2021 Apr 30. PubMed |
| HIF1alpha-dependent induction of the mitochondrial chaperone TRAP1 regulates bioenergetic adaptations to hypoxia. Laquatra C, Sanchez-Martin C, Dinarello A, Cannino G, Minervini G, Moroni E, Schiavone M, Tosatto S, Argenton F, Colombo G, Bernardi P, Masgras I, Rasola A. Cell Death Dis. 2021 May 1;12(5):434. doi: 10.1038/s41419-021-03716-6. PubMed |
| Quantitative proteomic analysis of extracellular vesicle subgroups isolated by an optimized method combining polymer-based precipitation and size exclusion chromatography. Martinez-Greene JA, Hernandez-Ortega K, Quiroz-Baez R, Resendis-Antonio O, Pichardo-Casas I, Sinclair DA, Budnik B, Hidalgo-Miranda A, Uribe-Querol E, Ramos-Godinez MDP, Martinez-Martinez E. J Extracell Vesicles. 2021 Apr;10(6):e12087. doi: 10.1002/jev2.12087. Epub 2021 Apr 27. PubMed |
| Host-Dependent Phenotypic Resistance to EGFR Tyrosine Kinase Inhibitors. Haga Y, Marrocco I, Noronha A, Uribe ML, Nataraj NB, Sekar A, Drago-Garcia D, Borgoni S, Lindzen M, Giri S, Wiemann S, Tsutsumi Y, Yarden Y. Cancer Res. 2021 Jul 15;81(14):3862-3875. doi: 10.1158/0008-5472.CAN-20-3555. Epub 2021 May 3. PubMed |
| Delineating the heterogeneity of matrix-directed differentiation toward soft and stiff tissue lineages via single-cell profiling. Brielle S, Bavli D, Motzik A, Kan-Tor Y, Sun X, Kozulin C, Avni B, Ram O, Buxboim A. Proc Natl Acad Sci U S A. 2021 May 11;118(19). pii: 2016322118. doi: 10.1073/pnas.2016322118. PubMed |
| Reversible switching of primary cells between normal and malignant state by oncogenic virus KSHV and CRISPR/Cas9-mediated targeting of a major viral latent protein. Ju E, Li T, Ramos da Silva S, Markazi A, Gao SJ. J Med Virol. 2021 Aug;93(8):5065-5075. doi: 10.1002/jmv.27046. Epub 2021 May 3. PubMed |
| The Zinc Finger Antiviral Protein ZAP Restricts Human Cytomegalovirus and Selectively Binds and Destabilizes Viral UL4/UL5 Transcripts. Gonzalez-Perez AC, Stempel M, Wyler E, Urban C, Piras A, Hennig T, Ganskih S, Wei Y, Heim A, Landthaler M, Pichlmair A, Dolken L, Munschauer M, Erhard F, Brinkmann MM. mBio. 2021 May 4;12(3). pii: mBio.02683-20. doi: 10.1128/mBio.02683-20. PubMed |
| Structure of the full-length human Pannexin1 channel and insights into its role in pyroptosis. Zhang S, Yuan B, Lam JH, Zhou J, Zhou X, Ramos-Mandujano G, Tian X, Liu Y, Han R, Li Y, Gao X, Li M, Yang M. Cell Discov. 2021 May 4;7(1):30. doi: 10.1038/s41421-021-00259-0. PubMed |
| SAM homeostasis is regulated by CFIm-mediated splicing of MAT2A. Scarborough AM, Flaherty JN, Hunter OV, Liu K, Kumar A, Xing C, Tu BP, Conrad NK. Elife. 2021 May 5;10. pii: 64930. doi: 10.7554/eLife.64930. PubMed |
| NFIB induces functional astrocytes from human pluripotent stem cell-derived neural precursor cells mimicking in vivo astrogliogenesis. Yeon GB, Shin WH, Yoo SH, Kim D, Jeon BM, Park WU, Bae Y, Park JY, You S, Na D, Kim DS. J Cell Physiol. 2021 May 5. doi: 10.1002/jcp.30405. PubMed |
| High-Level Production of Recombinant Eukaryotic Proteins from Mammalian Cells Using Lentivirus. Behiels E, Elegheert J. Methods Mol Biol. 2021;2305:83-104. doi: 10.1007/978-1-0716-1406-8_4. PubMed |
| Cohesin-protein Shugoshin-1 controls cardiac automaticity via HCN4 pacemaker channel. Liu D, Song AT, Qi X, van Vliet PP, Xiao J, Xiong F, Andelfinger G, Nattel S. Nat Commun. 2021 May 5;12(1):2551. doi: 10.1038/s41467-021-22737-5. PubMed |
| Minimized combinatorial CRISPR screens identify genetic interactions in autophagy. Diehl V, Wegner M, Grumati P, Husnjak K, Schaubeck S, Gubas A, Shah VJ, Polat IH, Langschied F, Prieto-Garcia C, Muller K, Kalousi A, Ebersberger I, Brandts CH, Dikic I, Kaulich M. Nucleic Acids Res. 2021 Jun 4;49(10):5684-5704. doi: 10.1093/nar/gkab309. PubMed |
| MyD88 oligomer size functions as a physical threshold to trigger IL1R Myddosome signaling. Deliz-Aguirre R, Cao F, Gerpott FHU, Auevechanichkul N, Chupanova M, Mun Y, Ziska E, Taylor MJ. J Cell Biol. 2021 Jul 5;220(7). pii: 212080. doi: 10.1083/jcb.202012071. Epub 2021 May 6. PubMed |
| Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains. Piette BL, Alerasool N, Lin ZY, Lacoste J, Lam MHY, Qian WW, Tran S, Larsen B, Campos E, Peng J, Gingras AC, Taipale M. Mol Cell. 2021 Jun 17;81(12):2549-2565.e8. doi: 10.1016/j.molcel.2021.04.012. Epub 2021 May 5. PubMed |
| Targeting non-canonical activation of GLI1 by the SOX2-BRD4 transcriptional complex improves the efficacy of HEDGEHOG pathway inhibition in melanoma. Pietrobono S, Gaudio E, Gagliardi S, Zitani M, Carrassa L, Migliorini F, Petricci E, Manetti F, Makukhin N, Bond AG, Paradise BD, Ciulli A, Fernandez-Zapico ME, Bertoni F, Stecca B. Oncogene. 2021 Jun;40(22):3799-3814. doi: 10.1038/s41388-021-01783-9. Epub 2021 May 6. PubMed |
| Membrane protein regulators of melanoma pulmonary colonisation identified using a CRISPRa screen and spontaneous metastasis assay in mice. van der Weyden L, Offord V, Turner G, Swiatkowska A, Speak AO, Adams DJ. G3 (Bethesda). 2021 May 7. pii: 6272227. doi: 10.1093/g3journal/jkab157. PubMed |
| Marker-free quantification of repair pathway utilization at Cas9-induced double-strand breaks. Feng W, Simpson DA, Cho JE, Carvajal-Garcia J, Smith CM, Headley KM, Hathaway N, Ramsden DA, Gupta GP. Nucleic Acids Res. 2021 May 21;49(9):5095-5105. doi: 10.1093/nar/gkab299. PubMed |
| A Validated Functional Analysis of Partner and Localizer of BRCA2 Missense Variants for Use in Clinical Variant Interpretation. Brnich SE, Arteaga EC, Wang Y, Tan X, Berg JS. J Mol Diagn. 2021 Jul;23(7):847-864. doi: 10.1016/j.jmoldx.2021.04.010. Epub 2021 May 6. PubMed |
| Coiled-Coil Domain-Containing 68 Downregulation Promotes Colorectal Cancer Cell Growth by Inhibiting ITCH-Mediated CDK4 Degradation. Wang C, Li H, Wu L, Jiao X, Jin Z, Zhu Y, Fang Z, Zhang X, Huang H, Zhao L. Front Oncol. 2021 Apr 22;11:668743. doi: 10.3389/fonc.2021.668743. eCollection 2021. PubMed |
| Effects of Amyloid Precursor Protein Overexpression on NF-kappaB, Rho-GTPase and Pro-Apoptosis Bcl-2 Pathways in Neuronal Cells. Chan HH, Leong YQ, Voon SM, Pan ML, Leong CO, Lim CL, Koh RY. Rep Biochem Mol Biol. 2021 Jan;9(4):417-425. doi: 10.52547/rbmb.9.4.417. PubMed |
| In vivo CRISPR screening for novel noncoding RNA functional targets in glioblastoma models. Attenello FJ, Tsung K, Bishara I, Loh YE, Chen TC. J Neurosci Res. 2021 Sep;99(9):2029-2045. doi: 10.1002/jnr.24850. Epub 2021 May 10. PubMed |
| Smac mimetics and TRAIL cooperate to induce MLKL-dependent necroptosis in Burkitt's lymphoma cell lines. Koch A, Jeiler B, Roedig J, van Wijk SJL, Dolgikh N, Fulda S. Neoplasia. 2021 May;23(5):539-550. doi: 10.1016/j.neo.2021.03.003. Epub 2021 May 7. PubMed |
| Cell-surface SLC nucleoside transporters and purine levels modulate BRD4-dependent chromatin states. Li KC, Girardi E, Kartnig F, Grosche S, Pemovska T, Bigenzahn JW, Goldmann U, Sedlyarov V, Bensimon A, Schick S, Lin JG, Gurtl B, Reil D, Klavins K, Kubicek S, Sdelci S, Superti-Furga G. Nat Metab. 2021 May;3(5):651-664. doi: 10.1038/s42255-021-00386-8. Epub 2021 May 10. PubMed |
| Identification of poly(ADP-ribose) polymerase 9 (PARP9) as a noncanonical sensor for RNA virus in dendritic cells. Xing J, Zhang A, Du Y, Fang M, Minze LJ, Liu YJ, Li XC, Zhang Z. Nat Commun. 2021 May 11;12(1):2681. doi: 10.1038/s41467-021-23003-4. PubMed |
| Probing RAS Function with Monobodies. Khan I, O'Bryan JP. Methods Mol Biol. 2021;2262:281-302. doi: 10.1007/978-1-0716-1190-6_17. PubMed |
| Delete_A Facile Method to Engineer Mutant Kras Alleles in an Isogenic Cell Background. Budagyan K, Chernoff J. Methods Mol Biol. 2021;2262:323-334. doi: 10.1007/978-1-0716-1190-6_20. PubMed |
| RIPK1 is a negative mediator in Aquaporin 1-driven triple-negative breast carcinoma progression and metastasis. Yin Z, Chen W, Yin J, Sun J, Xie Q, Wu M, Zeng F, Ren H. NPJ Breast Cancer. 2021 May 12;7(1):53. doi: 10.1038/s41523-021-00261-5. PubMed |
| Structural basis for broad coronavirus neutralization. Sauer MM, Tortorici MA, Park YJ, Walls AC, Homad L, Acton OJ, Bowen JE, Wang C, Xiong X, de van der Schueren W, Quispe J, Hoffstrom BG, Bosch BJ, McGuire AT, Veesler D. Nat Struct Mol Biol. 2021 Jun;28(6):478-486. doi: 10.1038/s41594-021-00596-4. Epub 2021 May 12. PubMed |
| SOX9-induced Generation of Functional Astrocytes Supporting Neuronal Maturation in an All-human System. Neyrinck K, Van Den Daele J, Vervliet T, De Smedt J, Wierda K, Nijs M, Vanbokhoven T, D'hondt A, Planque M, Fendt SM, Shih PY, Seibt F, Almenar JP, Kreir M, Kumar D, Broccoli V, Bultynck G, Ebneth A, Cabrera-Socorro A, Verfaillie C. Stem Cell Rev Rep. 2021 May 12. pii: 10.1007/s12015-021-10179-x. doi: 10.1007/s12015-021-10179-x. PubMed |
| Hyperbaric oxygen promotes not only glioblastoma proliferation but also chemosensitization by inhibiting HIF1alpha/HIF2alpha-Sox2. Wang P, Gong S, Pan J, Wang J, Zou D, Xiong S, Zhao L, Yan Q, Deng Y, Wu N, Liao B. Cell Death Discov. 2021 May 13;7(1):103. doi: 10.1038/s41420-021-00486-0. PubMed |
| Differentiation-related zinc finger protein 750 suppresses cell growth in esophageal squamous cell carcinoma. Ana Choi SS, Ko JM, Yu VZ, Ning L, Lung ML. Oncol Lett. 2021 Jul;22(1):513. doi: 10.3892/ol.2021.12774. Epub 2021 May 5. PubMed |
Quantifying persistence in the T-cell signaling network using an optically controllable antigen receptor.
Harris MJ, Fuyal M, James JR.
Mol Syst Biol. 2021 May;17(5):e10091. doi: 10.15252/msb.202010091.
PubMed
Associated Plasmids |
| Rab34 GTPase mediates ciliary membrane formation in the intracellular ciliogenesis pathway. Ganga AK, Kennedy MC, Oguchi ME, Gray S, Oliver KE, Knight TA, De La Cruz EM, Homma Y, Fukuda M, Breslow DK. Curr Biol. 2021 Jul 12;31(13):2895-2905.e7. doi: 10.1016/j.cub.2021.04.075. Epub 2021 May 13. PubMed |
| Loss of the WNT9a ligand aggravates the rheumatoid arthritis-like symptoms in hTNF transgenic mice. Teufel S, Kockemann P, Fabritius C, Wolff LI, Bertrand J, Pap T, Hartmann C. Cell Death Dis. 2021 May 15;12(5):494. doi: 10.1038/s41419-021-03786-6. PubMed |
| G-protein coupled receptor 35 (GPR35) regulates the colonic epithelial cell response to enterotoxigenic Bacteroides fragilis. Boleij A, Fathi P, Dalton W, Park B, Wu X, Huso D, Allen J, Besharati S, Anders RA, Housseau F, Mackenzie AE, Jenkins L, Milligan G, Wu S, Sears CL. Commun Biol. 2021 May 14;4(1):585. doi: 10.1038/s42003-021-02014-3. PubMed |
| Single AAV-mediated CRISPR-Nme2Cas9 efficiently reduces mutant hTTR expression in a transgenic mouse model of transthyretin amyloidosis. Wen J, Cao T, Wu J, Chen Y, Zhi S, Huang Y, Zhen P, Wu G, Aagaard L, Zhong J, Liang P, Huang J. Mol Ther. 2022 Jan 5;30(1):164-174. doi: 10.1016/j.ymthe.2021.05.010. Epub 2021 May 14. PubMed |
| Dihydrotanshinone Inhibits Hepatocellular Carcinoma by Suppressing the JAK2/STAT3 Pathway. Hu X, Jiao F, Zhang L, Jiang Y. Front Pharmacol. 2021 Apr 29;12:654986. doi: 10.3389/fphar.2021.654986. eCollection 2021. PubMed |
| NF-kappaB c-Rel Is Dispensable for the Development but Is Required for the Cytotoxic Function of NK Cells. Vicioso Y, Wong DP, Roy NK, Das N, Zhang K, Ramakrishnan P, Parameswaran R. Front Immunol. 2021 Apr 29;12:652786. doi: 10.3389/fimmu.2021.652786. eCollection 2021. PubMed |
| KAT6A, a novel regulator of beta-catenin, promotes tumorigenicity and chemoresistance in ovarian cancer by acetylating COP1. Liu W, Zhan Z, Zhang M, Sun B, Shi Q, Luo F, Zhang M, Zhang W, Hou Y, Xiao X, Li Y, Feng H. Theranostics. 2021 Apr 15;11(13):6278-6292. doi: 10.7150/thno.57455. eCollection 2021. PubMed |
| Impairment of the ER/mitochondria compartment in human cardiomyocytes with PLN p.Arg14del mutation. Cuello F, Knaust AE, Saleem U, Loos M, Raabe J, Mosqueira D, Laufer S, Schweizer M, van der Kraak P, Flenner F, Ulmer BM, Braren I, Yin X, Theofilatos K, Ruiz-Orera J, Patone G, Klampe B, Schulze T, Piasecki A, Pinto Y, Vink A, Hubner N, Harding S, Mayr M, Denning C, Eschenhagen T, Hansen A. EMBO Mol Med. 2021 Jun 7;13(6):e13074. doi: 10.15252/emmm.202013074. Epub 2021 May 16. PubMed |
| ZMPSTE24 Regulates SARS-CoV-2 Spike Protein-enhanced Expression of Endothelial PAI-1. Han M, Pandey D. Am J Respir Cell Mol Biol. 2021 Sep;65(3):300-308. doi: 10.1165/rcmb.2020-0544OC. PubMed |
| mTOR controls endoplasmic reticulum-Golgi apparatus trafficking of VSVg in specific cell types. Koscielny A, Liszewska E, Machnicka K, Wezyk M, Kotulska K, Jaworski J. Cell Mol Biol Lett. 2021 May 18;26(1):18. doi: 10.1186/s11658-021-00262-z. PubMed |
| A Generic, Scalable, and Rapid Time-Resolved Forster Resonance Energy Transfer-Based Assay for Antigen Detection-SARS-CoV-2 as a Proof of Concept. Rusanen J, Kareinen L, Szirovicza L, Ugurlu H, Levanov L, Jaaskelainen A, Ahava M, Kurkela S, Saksela K, Hedman K, Vapalahti O, Hepojoki J. mBio. 2021 May 18;12(3). pii: mBio.00902-21. doi: 10.1128/mBio.00902-21. PubMed |
| A virulent Bacillus cereus strain from deep-sea cold seep induces pyroptosis in a manner that involves NLRP3 inflammasome, JNK pathway, and lysosomal rupture. Zhao Y, Jiang S, Zhang J, Guan XL, Sun BG, Sun L. Virulence. 2021 Dec;12(1):1362-1376. doi: 10.1080/21505594.2021.1926649. PubMed |
| Inhibitory affinity modulation of FcgammaRIIA ligand binding by glycosphingolipids by inside-out signaling. Okubo K, Brenner MD, Cullere X, Saggu G, Patchen ML, Bose N, Mihori S, Yuan Z, Lowell CA, Zhu C, Mayadas TN. Cell Rep. 2021 May 18;35(7):109142. doi: 10.1016/j.celrep.2021.109142. PubMed |
| Cargo receptor-assisted endoplasmic reticulum export of pathogenic alpha1-antitrypsin polymers. Ordonez A, Harding HP, Marciniak SJ, Ron D. Cell Rep. 2021 May 18;35(7):109144. doi: 10.1016/j.celrep.2021.109144. PubMed |
| The metabolite alpha-KG induces GSDMC-dependent pyroptosis through death receptor 6-activated caspase-8. Zhang JY, Zhou B, Sun RY, Ai YL, Cheng K, Li FN, Wang BR, Liu FJ, Jiang ZH, Wang WJ, Zhou D, Chen HZ, Wu Q. Cell Res. 2021 Sep;31(9):980-997. doi: 10.1038/s41422-021-00506-9. Epub 2021 May 19. PubMed |
| Interpreting type 1 diabetes risk with genetics and single-cell epigenomics. Chiou J, Geusz RJ, Okino ML, Han JY, Miller M, Melton R, Beebe E, Benaglio P, Huang S, Korgaonkar K, Heller S, Kleger A, Preissl S, Gorkin DU, Sander M, Gaulton KJ. Nature. 2021 Jun;594(7863):398-402. doi: 10.1038/s41586-021-03552-w. Epub 2021 May 19. PubMed |
| Molecular signature and colony morphology affect in vitro pluripotency of porcine induced pluripotent stem cells. Setthawong P, Phakdeedindan P, Techakumphu M, Tharasanit T. Reprod Domest Anim. 2021 Aug;56(8):1104-1116. doi: 10.1111/rda.13954. Epub 2021 May 30. PubMed |
| The promiscuous binding pocket of SLC35A1 ensures redundant transport of CDP-ribitol to the Golgi. Ury B, Potelle S, Caligiore F, Whorton MR, Bommer GT. J Biol Chem. 2021 Jan-Jun;296:100789. doi: 10.1016/j.jbc.2021.100789. Epub 2021 May 18. PubMed |
| Comprehensive interactome analysis of the spike protein of swine acute diarrhea syndrome coronavirus. Wang Q, Luo Y, Shang W, Shi Z, Xiao G, Zhang L. Biosaf Health. 2021 Jun;3(3):156-163. doi: 10.1016/j.bsheal.2021.05.002. Epub 2021 May 17. PubMed |
| Avadomide induces degradation of ZMYM2 fusion oncoproteins in hematologic malignancies. Renneville A, Gasser JA, Grinshpun DE, Jean Beltran PM, Udeshi ND, Matyskiela ME, Clayton T, McConkey M, Viswanathan K, Tepper A, Guirguis AA, Sellar RS, Cotteret S, Marzac C, Saada V, De Botton S, Kiladjian JJ, Cayuela JM, Rolfe M, Chamberlain PP, Carr SA, Ebert BL. Blood Cancer Discov. 2021 May;2(3):250-265. doi: 10.1158/2643-3230.bcd-20-0105. Epub 2021 Mar 10. PubMed |
| Genetic manipulation of adhesion GPCR CD97/ADGRE5 modulates invasion in patient-derived glioma stem cells. Eichberg DG, Slepak TI, Pascoini AL, Komotar RJ, Ivan ME. J Neurooncol. 2021 Jul;153(3):383-391. doi: 10.1007/s11060-021-03778-8. Epub 2021 May 24. PubMed |
| Platelet-Derived Growth Factor Receptor-alpha Subunit Targeting Suppresses Metastasis in Advanced Thyroid Cancer In Vitro and In Vivo. Lin CL, Tsai ML, Chen YH, Liu WN, Lin CY, Hsu KW, Huang CY, Chang YJ, Wei PL, Chen SH, Huang LC, Lee CH. Biomol Ther (Seoul). 2021 Sep 1;29(5):551-561. doi: 10.4062/biomolther.2020.205. PubMed |
| Cul3 regulates cytoskeleton protein homeostasis and cell migration during a critical window of brain development. Morandell J, Schwarz LA, Basilico B, Tasciyan S, Dimchev G, Nicolas A, Sommer C, Kreuzinger C, Dotter CP, Knaus LS, Dobler Z, Cacci E, Schur FKM, Danzl JG, Novarino G. Nat Commun. 2021 May 24;12(1):3058. doi: 10.1038/s41467-021-23123-x. PubMed |
| In vivo genome-wide CRISPR screen reveals breast cancer vulnerabilities and synergistic mTOR/Hippo targeted combination therapy. Dai M, Yan G, Wang N, Daliah G, Edick AM, Poulet S, Boudreault J, Ali S, Burgos SA, Lebrun JJ. Nat Commun. 2021 May 24;12(1):3055. doi: 10.1038/s41467-021-23316-4. PubMed |
| CD13 is a critical regulator of cell-cell fusion in osteoclastogenesis. Ghosh M, Kelava T, Madunic IV, Kalajzic I, Shapiro LH. Sci Rep. 2021 May 24;11(1):10736. doi: 10.1038/s41598-021-90271-x. PubMed |
| Mitohormesis reprogrammes macrophage metabolism to enforce tolerance. Timblin GA, Tharp KM, Ford B, Winchester JM, Wang J, Zhu S, Khan RI, Louie SK, Iavarone AT, Ten Hoeve J, Nomura DK, Stahl A, Saijo K. Nat Metab. 2021 May;3(5):618-635. doi: 10.1038/s42255-021-00392-w. Epub 2021 May 20. PubMed |
| SYNCRIP facilitates porcine parvovirus viral DNA replication through the alternative splicing of NS1 mRNA to promote NS2 mRNA formation. Chen S, Miao B, Chen N, Chen C, Shao T, Zhang X, Chang L, Zhang X, Du Q, Huang Y, Tong D. Vet Res. 2021 May 25;52(1):73. doi: 10.1186/s13567-021-00938-6. PubMed |
| FOXM1 repression increases mitotic death upon antimitotic chemotherapy through BMF upregulation. Vaz S, Ferreira FJ, Macedo JC, Leor G, Ben-David U, Bessa J, Logarinho E. Cell Death Dis. 2021 May 25;12(6):542. doi: 10.1038/s41419-021-03822-5. PubMed |
| Phenotypic plasticity underlies local invasion and distant metastasis in colon cancer. Sacchetti A, Teeuwssen M, Verhagen M, Joosten R, Xu T, Stabile R, van der Steen B, Watson MM, Gusinac A, Kim WK, Ubink I, Van de Werken HJ, Fumagalli A, Paauwe M, Van Rheenen J, Sansom OJ, Kranenburg O, Fodde R. Elife. 2021 May 26;10. pii: 61461. doi: 10.7554/eLife.61461. PubMed |
| An Amino Acid Polymorphism within the HIV-1 Nef Dileucine Motif Functionally Uncouples Cell Surface CD4 and SERINC5 Downregulation. Mumby MJ, Johnson AL, Trothen SM, Edgar CR, Gibson R, Stathopulos PB, Arts EJ, Dikeakos JD. J Virol. 2021 Jul 26;95(16):e0058821. doi: 10.1128/JVI.00588-21. Epub 2021 Jul 26. PubMed |
| ELAVL1 primarily couples mRNA stability with the 3' UTRs of interferon-stimulated genes. Rothamel K, Arcos S, Kim B, Reasoner C, Lisy S, Mukherjee N, Ascano M. Cell Rep. 2021 May 25;35(8):109178. doi: 10.1016/j.celrep.2021.109178. PubMed |
| AMPKalpha loss promotes KRAS-mediated lung tumorigenesis. La Montagna M, Shi L, Magee P, Sahoo S, Fassan M, Garofalo M. Cell Death Differ. 2021 Sep;28(9):2673-2689. doi: 10.1038/s41418-021-00777-0. Epub 2021 May 26. PubMed |
| Optimal Ratio of Wnt3a Expression in Human Mesenchymal Stem Cells Promotes Axonal Regeneration in Spinal Cord Injured Rat Model. Yoon HH, Lee HJ, Min J, Kim JH, Park JH, Kim JH, Kim SW, Lee H, Jeon SR. J Korean Neurosurg Soc. 2021 Sep;64(5):705-715. doi: 10.3340/jkns.2021.0003. Epub 2021 May 28. PubMed |
| Deacylcortivazol-like pyrazole regioisomers reveal a more accommodating expanded binding pocket for the glucocorticoid receptor. Zimmerman JAO, Fang M, Doumbia B, Neyman A, Cha JH, Thomas M, Hall B, Wu M, Wilson AM, Pufall MA. RSC Med Chem. 2020 Dec 8;12(2):203-212. doi: 10.1039/d0md00278j. eCollection 2021 Mar 4. PubMed |
| SARS-CoV-2 exacerbates proinflammatory responses in myeloid cells through C-type lectin receptors and Tweety family member 2. Lu Q, Liu J, Zhao S, Gomez Castro MF, Laurent-Rolle M, Dong J, Ran X, Damani-Yokota P, Tang H, Karakousi T, Son J, Kaczmarek ME, Zhang Z, Yeung ST, McCune BT, Chen RE, Tang F, Ren X, Chen X, Hsu JCC, Teplova M, Huang B, Deng H, Long Z, Mudianto T, Jin S, Lin P, Du J, Zang R, Su TT, Herrera A, Zhou M, Yan R, Cui J, Zhu J, Zhou Q, Wang T, Ma J, Koralov SB, Zhang Z, Aifantis I, Segal LN, Diamond MS, Khanna KM, Stapleford KA, Cresswell P, Liu Y, Ding S, Xie Q, Wang J. Immunity. 2021 Jun 8;54(6):1304-1319.e9. doi: 10.1016/j.immuni.2021.05.006. Epub 2021 May 9. PubMed |
| MicroRNA-30c delivered by bone marrow-mesenchymal stem cells induced apoptosis and diminished cell invasion in U-251 glioblastoma cell line. Mahjoor M, Afkhami H, Mollaei M, Nasr A, Shahriary S, Khorrami S. Life Sci. 2021 Aug 15;279:119643. doi: 10.1016/j.lfs.2021.119643. Epub 2021 May 25. PubMed |
| Pooled CRISPR screening in pancreatic cancer cells implicates co-repressor complexes as a cause of multiple drug resistance via regulation of epithelial-to-mesenchymal transition. Ramaker RC, Hardigan AA, Gordon ER, Wright CA, Myers RM, Cooper SJ. BMC Cancer. 2021 May 29;21(1):632. doi: 10.1186/s12885-021-08388-1. PubMed |
| Ultra-high-throughput single-cell RNA sequencing and perturbation screening with combinatorial fluidic indexing. Datlinger P, Rendeiro AF, Boenke T, Senekowitsch M, Krausgruber T, Barreca D, Bock C. Nat Methods. 2021 Jun;18(6):635-642. doi: 10.1038/s41592-021-01153-z. Epub 2021 May 31. PubMed |
| Histone deficiency and accelerated replication stress in T cell aging. Kim C, Jin J, Ye Z, Jadhav RR, Gustafson CE, Hu B, Cao W, Tian L, Weyand CM, Goronzy JJ. J Clin Invest. 2021 Jun 1;131(11). pii: e143632. doi: 10.1172/JCI143632. PubMed |
| Altering transcription factor binding reveals comprehensive transcriptional kinetics of a basic gene. Popp AP, Hettich J, Gebhardt JCM. Nucleic Acids Res. 2021 Jun 21;49(11):6249-6266. doi: 10.1093/nar/gkab443. PubMed |
| Inhibitory effect on SARS-CoV-2 infection of neferine by blocking Ca(2+) -dependent membrane fusion. Yang Y, Yang P, Huang C, Wu Y, Zhou Z, Wang X, Wang S. J Med Virol. 2021 Oct;93(10):5825-5832. doi: 10.1002/jmv.27117. Epub 2021 Jun 9. PubMed |
| The Lysine Methylase SMYD3 Modulates Mesendodermal Commitment during Development. Fittipaldi R, Floris P, Proserpio V, Cotelli F, Beltrame M, Caretti G. Cells. 2021 May 18;10(5). pii: cells10051233. doi: 10.3390/cells10051233. PubMed |
| IGF1-mediated HOXA13 overexpression promotes colorectal cancer metastasis through upregulating ACLY and IGF1R. Qiao C, Huang W, Chen J, Feng W, Zhang T, Wang Y, Liu D, Ji X, Xie M, Sun M, Fan D, Wu K, Xia L. Cell Death Dis. 2021 Jun 1;12(6):564. doi: 10.1038/s41419-021-03833-2. PubMed |
| Short lifespan of syngeneic transplanted MSC is a consequence of in vivo apoptosis and immune cell recruitment in mice. Preda MB, Neculachi CA, Fenyo IM, Vacaru AM, Publik MA, Simionescu M, Burlacu A. Cell Death Dis. 2021 Jun 2;12(6):566. doi: 10.1038/s41419-021-03839-w. PubMed |
| WNT5A inhibition alters the malignant peripheral nerve sheath tumor microenvironment and enhances tumor growth. Thomson CS, Pundavela J, Perrino MR, Coover RA, Choi K, Chaney KE, Rizvi TA, Largaespada DA, Ratner N. Oncogene. 2021 Jun;40(24):4229-4241. doi: 10.1038/s41388-021-01773-x. Epub 2021 Jun 2. PubMed |
| Apc-mutant cells act as supercompetitors in intestinal tumour initiation. van Neerven SM, de Groot NE, Nijman LE, Scicluna BP, van Driel MS, Lecca MC, Warmerdam DO, Kakkar V, Moreno LF, Vieira Braga FA, Sanches DR, Ramesh P, Ten Hoorn S, Aelvoet AS, van Boxel MF, Koens L, Krawczyk PM, Koster J, Dekker E, Medema JP, Winton DJ, Bijlsma MF, Morrissey E, Leveille N, Vermeulen L. Nature. 2021 Jun;594(7863):436-441. doi: 10.1038/s41586-021-03558-4. Epub 2021 Jun 2. PubMed |
| Tight nanoscale clustering of Fcgamma receptors using DNA origami promotes phagocytosis. Kern N, Dong R, Douglas SM, Vale RD, Morrissey MA. Elife. 2021 Jun 3;10. pii: 68311. doi: 10.7554/eLife.68311. PubMed |
| Calcium signaling mediates a biphasic mechanoadaptive response of endothelial cells to cyclic mechanical stretch. Miroshnikova YA, Manet S, Li X, Wickstrom SA, Faurobert E, Albiges-Rizo C. Mol Biol Cell. 2021 Aug 19;32(18):1724-1736. doi: 10.1091/mbc.E21-03-0106. Epub 2021 Jun 3. PubMed |
| Src-Yap1 signaling axis controls the trophectoderm and epiblast lineage differentiation in mouse embryonic stem cells. Luo J, Zou H, Li P. Stem Cell Res. 2021 Jul;54:102413. doi: 10.1016/j.scr.2021.102413. Epub 2021 May 29. PubMed |
| Establishment of a fluorescent reporter of RNA-polymerase II activity to identify dormant cells. Freter R, Falletta P, Omrani O, Rasa M, Herbert K, Annunziata F, Minetti A, Krepelova A, Adam L, Kappel S, Rudiger T, Wang ZQ, Goding CR, Neri F. Nat Commun. 2021 Jun 3;12(1):3318. doi: 10.1038/s41467-021-23580-4. PubMed |
Non-invasive and high-throughput interrogation of exon-specific isoform expression.
Truong DJ, Phlairaharn T, Esswein B, Gruber C, Tumen D, Baligacs E, Armbrust N, Vaccaro FL, Lederer EM, Beck EM, Geilenkeuser J, Goppert S, Krumwiede L, Gratz C, Raffl G, Schwarz D, Zirngibl M, Zivanic M, Beyer M, Korner JD, Santl T, Evsyukov V, Strauss T, Schwarz SC, Hoglinger GU, Heutink P, Doll S, Conrad M, Giesert F, Wurst W, Westmeyer GG.
Nat Cell Biol. 2021 Jun;23(6):652-663. doi: 10.1038/s41556-021-00678-x. Epub 2021 Jun 3.
PubMed
Associated Plasmids |
| Reprogramming an energetic AKT-PAK5 axis boosts axon energy supply and facilitates neuron survival and regeneration after injury and ischemia. Huang N, Li S, Xie Y, Han Q, Xu XM, Sheng ZH. Curr Biol. 2021 Jul 26;31(14):3098-3114.e7. doi: 10.1016/j.cub.2021.04.079. Epub 2021 Jun 3. PubMed |
| ERK signaling mediates resistance to immunomodulatory drugs in the bone marrow microenvironment. Liu J, Hideshima T, Xing L, Wang S, Zhou W, Samur MK, Sewastianik T, Ogiya D, An G, Gao S, Yang L, Ji T, Bianchi G, Wen K, Tai YT, Munshi N, Richardson P, Carrasco R, Cang Y, Anderson KC. Sci Adv. 2021 Jun 4;7(23). pii: 7/23/eabg2697. doi: 10.1126/sciadv.abg2697. Print 2021 Jun. PubMed |
| Sunitinib and Axitinib increase secretion and glycolytic activity of small extracellular vesicles in renal cell carcinoma. Lim AR, Vincent BG, Weaver AM, Rathmell WK. Cancer Gene Ther. 2022 Jun;29(6):683-696. doi: 10.1038/s41417-021-00345-1. Epub 2021 Jun 4. PubMed |
| The RNA-binding protein HuR is a novel target of Pirh2 E3 ubiquitin ligase. Daks A, Petukhov A, Fedorova O, Shuvalov O, Kizenko A, Tananykina E, Vasileva E, Semenov O, Bottrill A, Barlev N. Cell Death Dis. 2021 Jun 5;12(6):581. doi: 10.1038/s41419-021-03871-w. PubMed |
| uc.77- Downregulation Promotes Colorectal Cancer Cell Proliferation by Inhibiting FBXW8-Mediated CDK4 Protein Degradation. Zheng Z, Hong D, Zhang X, Chang Y, Sun N, Lin Z, Li H, Huang S, Zhang R, Xie Q, Huang H, Jin H. Front Oncol. 2021 May 19;11:673223. doi: 10.3389/fonc.2021.673223. eCollection 2021. PubMed |
| Protocol for genome-scale CRISPR screening in engineered lineage reporter hPSCs to study cell fate determination. Zhou Z, Ma L, Zhang X. STAR Protoc. 2021 May 20;2(2):100548. doi: 10.1016/j.xpro.2021.100548. eCollection 2021 Jun 18. PubMed |
| A phenotypically supervised single-cell analysis protocol to study within-cell-type heterogeneity of cultured mammalian cells. Chen K, Ozturk K, Liefeld T, Reich M, Mesirov JP, Carter H, Fraley SI. STAR Protoc. 2021 May 25;2(2):100561. doi: 10.1016/j.xpro.2021.100561. eCollection 2021 Jun 18. PubMed |
| Interferon regulatory factor 7 impairs cellular metabolism in aging adipose-derived stromal cells. Nodari A, Scambi I, Peroni D, Calabria E, Benati D, Mannucci S, Manfredi M, Frontini A, Visona S, Bozzato A, Sbarbati A, Schena F, Marengo E, Krampera M, Galie M. J Cell Sci. 2021 Jun 1;134(11). pii: 269034. doi: 10.1242/jcs.256230. Epub 2021 Jun 7. PubMed |
| SORBS2 is a genetic factor contributing to cardiac malformation of 4q deletion syndrome patients. Liang F, Wang B, Geng J, You G, Fa J, Zhang M, Sun H, Chen H, Fu Q, Zhang X, Zhang Z. Elife. 2021 Jun 8;10. pii: 67481. doi: 10.7554/eLife.67481. PubMed |
| SARS-CoV-2 RNAemia and proteomic trajectories inform prognostication in COVID-19 patients admitted to intensive care. Gutmann C, Takov K, Burnap SA, Singh B, Ali H, Theofilatos K, Reed E, Hasman M, Nabeebaccus A, Fish M, McPhail MJ, O'Gallagher K, Schmidt LE, Cassel C, Rienks M, Yin X, Auzinger G, Napoli S, Mujib SF, Trovato F, Sanderson B, Merrick B, Niazi U, Saqi M, Dimitrakopoulou K, Fernandez-Leiro R, Braun S, Kronstein-Wiedemann R, Doores KJ, Edgeworth JD, Shah AM, Bornstein SR, Tonn T, Hayday AC, Giacca M, Shankar-Hari M, Mayr M. Nat Commun. 2021 Jun 7;12(1):3406. doi: 10.1038/s41467-021-23494-1. PubMed |
| HOXA13 in etiology and oncogenic potential of Barrett's esophagus. Janmaat VT, Nesteruk K, Spaander MCW, Verhaar AP, Yu B, Silva RA, Phillips WA, Magierowski M, van de Winkel A, Stadler HS, Sandoval-Guzman T, van der Laan LJW, Kuipers EJ, Smits R, Bruno MJ, Fuhler GM, Clemons NJ, Peppelenbosch MP. Nat Commun. 2021 Jun 7;12(1):3354. doi: 10.1038/s41467-021-23641-8. PubMed |
| A cell-free assay implicates a role of sphingomyelin and cholesterol in STING phosphorylation. Takahashi K, Niki T, Ogawa E, Fumika K, Nishioka Y, Sawa M, Arai H, Mukai K, Taguchi T. Sci Rep. 2021 Jun 7;11(1):11996. doi: 10.1038/s41598-021-91562-z. PubMed |
| SLC26A6-selective inhibitor identified in a small-molecule screen blocks fluid absorption in small intestine. Cil O, Haggie PM, Tan JT, Rivera AA, Verkman AS. JCI Insight. 2021 Jun 8;6(11). pii: e147699. doi: 10.1172/jci.insight.147699. PubMed |
| NORAD-induced Pumilio phase separation is required for genome stability. Elguindy MM, Mendell JT. Nature. 2021 Jul;595(7866):303-308. doi: 10.1038/s41586-021-03633-w. Epub 2021 Jun 9. PubMed |
| TP73-AS1 is induced by YY1 during TMZ treatment and highly expressed in the aging brain. Mazor G, Smirnov D, Ben David H, Khrameeva E, Toiber D, Rotblat B. Aging (Albany NY). 2021 Jun 11;13(11):14843-14861. doi: 10.18632/aging.203182. Epub 2021 Jun 11. PubMed |
| Oxytocin receptor is a promising therapeutic target of malignant mesothelioma. Kodama Y, Tanaka I, Sato T, Hori K, Gen S, Morise M, Matsubara D, Sato M, Sekido Y, Hashimoto N. Cancer Sci. 2021 Sep;112(9):3520-3532. doi: 10.1111/cas.15025. Epub 2021 Jul 4. PubMed |
| Targeting Glucose Metabolism Sensitizes Pancreatic Cancer to MEK Inhibition. Yan L, Tu B, Yao J, Gong J, Carugo A, Bristow CA, Wang Q, Zhu C, Dai B, Kang Y, Han L, Feng N, Jin Y, Fleming J, Heffernan TP, Yao W, Ying H. Cancer Res. 2021 Aug 1;81(15):4054-4065. doi: 10.1158/0008-5472.CAN-20-3792. Epub 2021 Jun 11. PubMed |
| Non-conditioned bone marrow chimeric mouse generation using culture-based enrichment of hematopoietic stem and progenitor cells. Ochi K, Morita M, Wilkinson AC, Iwama A, Yamazaki S. Nat Commun. 2021 Jun 11;12(1):3568. doi: 10.1038/s41467-021-23763-z. PubMed |
| Tailored generation of insulin producing cells from canine mesenchymal stem cells derived from bone marrow and adipose tissue. Rodprasert W, Nantavisai S, Pathanachai K, Pavasant P, Osathanon T, Sawangmake C. Sci Rep. 2021 Jun 11;11(1):12409. doi: 10.1038/s41598-021-91774-3. PubMed |
| Fatty Acids Activate the Transcriptional Coactivator YAP1 to Promote Liver Fibrosis via p38 Mitogen-Activated Protein Kinase. Salloum S, Jeyarajan AJ, Kruger AJ, Holmes JA, Shao T, Sojoodi M, Kim MH, Zhuo Z, Shroff SG, Kassa A, Corey KE, Khan SK, Lin W, Alatrakchi N, Schaefer EAK, Chung RT. Cell Mol Gastroenterol Hepatol. 2021 Jun 9;12(4):1297-1310. doi: 10.1016/j.jcmgh.2021.06.003. PubMed |
| Generation of recombinant antibodies by mammalian expression system for detecting S-metolachlor in environmental waters. Yu X, Zhang X, Xu J, Guo P, Li X, Wang H, Xu Z, Lei H, Shen X. J Hazard Mater. 2021 Sep 15;418:126305. doi: 10.1016/j.jhazmat.2021.126305. Epub 2021 Jun 5. PubMed |
| Positive natural selection of N6-methyladenosine on the RNAs of processed pseudogenes. Tan L, Cheng W, Liu F, Wang DO, Wu L, Cao N, Wang J. Genome Biol. 2021 Jun 13;22(1):180. doi: 10.1186/s13059-021-02402-2. PubMed |
| In vitro discovery of novel prokaryotic ion channel candidates for antiarrhythmic gene therapy. Wu T, Nguyen HX, Bursac N. Methods Enzymol. 2021;654:407-434. doi: 10.1016/bs.mie.2021.03.008. Epub 2021 Apr 9. PubMed |
| Extracellular signal-regulated kinase mediates chromatin rewiring and lineage transformation in lung cancer. Inoue Y, Nikolic A, Farnsworth D, Shi R, Johnson FD, Liu A, Ladanyi M, Somwar R, Gallo M, Lockwood WW. Elife. 2021 Jun 14;10. pii: 66524. doi: 10.7554/eLife.66524. PubMed |
| NLRP3 Inflammasome Assembly in Neutrophils Is Supported by PAD4 and Promotes NETosis Under Sterile Conditions. Munzer P, Negro R, Fukui S, di Meglio L, Aymonnier K, Chu L, Cherpokova D, Gutch S, Sorvillo N, Shi L, Magupalli VG, Weber ANR, Scharf RE, Waterman CM, Wu H, Wagner DD. Front Immunol. 2021 May 28;12:683803. doi: 10.3389/fimmu.2021.683803. eCollection 2021. PubMed |
| Caspase-Dependent Cleavage of DDX21 Suppresses Host Innate Immunity. Wu W, Qu Y, Yu S, Wang S, Yin Y, Liu Q, Meng C, Liao Y, Ur Rehman Z, Tan L, Song C, Qiu X, Liu W, Ding C, Sun Y. mBio. 2021 Jun 29;12(3):e0100521. doi: 10.1128/mBio.01005-21. Epub 2021 Jun 14. PubMed |
| p38 inhibition enhances TCR-T cell function and antagonizes the immunosuppressive activity of TGF-beta. Chen S, Zhang J, Shen M, Han X, Li S, Hu C, Wang W, Li L, Du L, Pang D, Tao K, Jin A. Int Immunopharmacol. 2021 Sep;98:107848. doi: 10.1016/j.intimp.2021.107848. Epub 2021 Jun 11. PubMed |
| Facile fabrication of antibacterial and antiviral perhydrolase-polydopamine composite coatings. Wang LS, Xu S, Gopal S, Kim E, Kim D, Brier M, Solanki K, Dordick JS. Sci Rep. 2021 Jun 14;11(1):12410. doi: 10.1038/s41598-021-91925-6. PubMed |
| Multiplex protein profiling method for extracellular vesicle protein detection. Sun L, Meckes DG Jr. Sci Rep. 2021 Jun 14;11(1):12477. doi: 10.1038/s41598-021-92012-6. PubMed |
| CRISPR mediated targeting of DUX4 distal regulatory element represses DUX4 target genes dysregulated in Facioscapulohumeral muscular dystrophy. Das S, Chadwick BP. Sci Rep. 2021 Jun 15;11(1):12598. doi: 10.1038/s41598-021-92096-0. PubMed |
| Mutagenesis of Human Cytomegalovirus Glycoprotein L Disproportionately Disrupts gH/gL/gO over gH/gL/pUL128-131. Schultz EP, Yu Q, Stegmann C, Day LZ, Lanchy JM, Ryckman BJ. J Virol. 2021 Aug 10;95(17):e0061221. doi: 10.1128/JVI.00612-21. Epub 2021 Aug 10. PubMed |
| VPS13D interacts with VCP/p97 and negatively regulates endoplasmic reticulum-mitochondria interactions. Du Y, Wang J, Xiong J, Fang N, Ji WK. Mol Biol Cell. 2021 Aug 1;32(16):1474-1486. doi: 10.1091/mbc.E21-03-0097. Epub 2021 Jun 16. PubMed |
| Binding of the Andes Virus Nucleocapsid Protein to RhoGDI Induces the Release and Activation of the Permeability Factor RhoA. Gorbunova EE, Mackow ER. J Virol. 2021 Aug 10;95(17):e0039621. doi: 10.1128/JVI.00396-21. Epub 2021 Aug 10. PubMed |
| A Novel Invadopodia-Specific Marker for Invasive and Pro-Metastatic Cancer Stem Cells. Huang SS, Liao WY, Hsu CC, Chan TS, Liao TY, Yang PM, Chen LT, Sung SY, Tsai KK. Front Oncol. 2021 May 31;11:638311. doi: 10.3389/fonc.2021.638311. eCollection 2021. PubMed |
| Genome-scale CRISPR-Cas9 screen of Wnt/beta-catenin signaling identifies therapeutic targets for colorectal cancer. Wan C, Mahara S, Sun C, Doan A, Chua HK, Xu D, Bian J, Li Y, Zhu D, Sooraj D, Cierpicki T, Grembecka J, Firestein R. Sci Adv. 2021 May 19;7(21). pii: 7/21/eabf2567. doi: 10.1126/sciadv.abf2567. Print 2021 May. PubMed |
| ULK1 inhibition overcomes compromised antigen presentation and restores antitumor immunity in LKB1 mutant lung cancer. Deng J, Thennavan A, Dolgalev I, Chen T, Li J, Marzio A, Poirier JT, Peng D, Bulatovic M, Mukhopadhyay S, Silver H, Papadopoulos E, Pyon V, Thakurdin C, Han H, Li F, Li S, Ding H, Hu H, Pan Y, Weerasekara V, Jiang B, Wang ES, Ahearn I, Philips M, Papagiannakopoulos T, Tsirigos A, Rothenberg E, Gainor J, Freeman GJ, Rudin CM, Gray NS, Hammerman PS, Pagano M, Heymach JV, Perou CM, Bardeesy N, Wong KK. Nat Cancer. 2021 May;2(5):503-514. doi: 10.1038/s43018-021-00208-6. Epub 2021 May 17. PubMed |
| The pan-cancer lncRNA PLANE regulates an alternative splicing program to promote cancer pathogenesis. Teng L, Feng YC, Guo ST, Wang PL, Qi TF, Yue YM, Wang SX, Zhang SN, Tang CX, La T, Zhang YY, Zhao XH, Gao JN, Wei LY, Zhang D, Wang JY, Shi Y, Liu XY, Li JM, Cao H, Liu T, Thorne RF, Jin L, Shao FM, Zhang XD. Nat Commun. 2021 Jun 18;12(1):3734. doi: 10.1038/s41467-021-24099-4. PubMed |
| Mist1 Inhibits Epithelial-Mesenchymal Transition in Gastric Adenocarcinoma via Downregulating the Wnt/beta-catenin Pathway. Xie X, Zhou Z, Song Y, Zhang X, Dang C, Zhang H. J Cancer. 2021 Jun 1;12(15):4574-4584. doi: 10.7150/jca.59138. eCollection 2021. PubMed |
| Role of the transcriptional regulator SP140 in resistance to bacterial infections via repression of type I interferons. Ji DX, Witt KC, Kotov DI, Margolis SR, Louie A, Chevee V, Chen KJ, Gaidt MM, Dhaliwal HS, Lee AY, Nishimura SL, Zamboni DS, Kramnik I, Portnoy DA, Darwin KH, Vance RE. Elife. 2021 Jun 21;10. pii: 67290. doi: 10.7554/eLife.67290. PubMed |
| BECN2 (beclin 2) Negatively Regulates Inflammasome Sensors Through ATG9A-Dependent but ATG16L1- and LC3-Independent Non-Canonical Autophagy. Deng G, Li C, Chen L, Xing C, Fu C, Qian C, Liu X, Wang HY, Zhu M, Wang RF. Autophagy. 2022 Feb;18(2):340-356. doi: 10.1080/15548627.2021.1934270. Epub 2021 Jun 21. PubMed |
| Aberrant activation of Rho/ROCK signaling in impaired polarity switching of colorectal micropapillary carcinoma. Onuma K, Sato Y, Okuyama H, Uematsu H, Homma K, Ohue M, Kondo J, Inoue M. J Pathol. 2021 Sep;255(1):84-94. doi: 10.1002/path.5748. Epub 2021 Jul 16. PubMed |
| Upregulation of the ErbB family by EZH2 in hepatocellular carcinoma confers resistance to FGFR inhibitor. Prawira A, Le TBU, Ho RZW, Huynh H. J Cancer Res Clin Oncol. 2021 Oct;147(10):2955-2968. doi: 10.1007/s00432-021-03703-6. Epub 2021 Jun 22. PubMed |
| The MLKL kinase-like domain dimerization is an indispensable step of mammalian MLKL activation in necroptosis signaling. Zhang Y, Liu J, Yu D, Zhu X, Liu X, Liao J, Li S, Wang H. Cell Death Dis. 2021 Jun 22;12(7):638. doi: 10.1038/s41419-021-03859-6. PubMed |
| CRISPR Interference (CRISPRi) and CRISPR Activation (CRISPRa) to Explore the Oncogenic lncRNA Network. Morelli E, Gulla' A, Amodio N, Taiana E, Neri A, Fulciniti M, Munshi NC. Methods Mol Biol. 2021;2348:189-204. doi: 10.1007/978-1-0716-1581-2_13. PubMed |
Positive feedback between the T cell kinase Zap70 and its substrate LAT acts as a clustering-dependent signaling switch.
Dine E, Reed EH, Toettcher JE.
Cell Rep. 2021 Jun 22;35(12):109280. doi: 10.1016/j.celrep.2021.109280.
PubMed
Associated Plasmids |
| DDB1 binds histone reader BRWD3 to activate the transcriptional cascade in adipogenesis and promote onset of obesity. Wang X, Wang HY, Hu GS, Tang WS, Weng L, Zhang Y, Guo H, Yao SS, Liu SY, Zhang GL, Han Y, Liu M, Zhang XD, Cen X, Shen HF, Xiao N, Liu CQ, Wang HR, Huang J, Liu W, Li P, Zhao TJ. Cell Rep. 2021 Jun 22;35(12):109281. doi: 10.1016/j.celrep.2021.109281. PubMed |
| Reduced PHLPP Expression Leads to EGFR-TKI Resistance in Lung Cancer by Activating PI3K-AKT and MAPK-ERK Dual Signaling. Wang W, Xia X, Chen K, Chen M, Meng Y, Lv D, Yang H. Front Oncol. 2021 Jun 8;11:665045. doi: 10.3389/fonc.2021.665045. eCollection 2021. PubMed |
| CHK1 inhibitor sensitizes resistant colorectal cancer stem cells to nortopsentin. Di Franco S, Parrino B, Gaggianesi M, Pantina VD, Bianca P, Nicotra A, Mangiapane LR, Lo Iacono M, Ganduscio G, Veschi V, Brancato OR, Glaviano A, Turdo A, Pillitteri I, Colarossi L, Cascioferro S, Carbone D, Pecoraro C, Fiori ME, De Maria R, Todaro M, Screpanti I, Cirrincione G, Diana P, Stassi G. iScience. 2021 May 29;24(6):102664. doi: 10.1016/j.isci.2021.102664. eCollection 2021 Jun 25. PubMed |
| Protocol to establish a lung adenocarcinoma immunotherapy allograft mouse model with FACS and immunofluorescence-based analysis of tumor response. Peng Z, Yu M, Lin J, Dong T, Zhang X, Shi M, Qin M, Li S, Guo W, Zhang H, Sun S. STAR Protoc. 2021 Jun 11;2(2):100595. doi: 10.1016/j.xpro.2021.100595. eCollection 2021 Jun 18. PubMed |
| Evaluation of glycolytic rates in human hematopoietic stem/progenitor cells after target gene depletion. Qing Y, Gao L, Han L, Su R, Chen J. STAR Protoc. 2021 Jun 11;2(2):100603. doi: 10.1016/j.xpro.2021.100603. eCollection 2021 Jun 18. PubMed |
| BAP1/ASXL complex modulation regulates epithelial-mesenchymal transition during trophoblast differentiation and invasion. Perez-Garcia V, Lea G, Lopez-Jimenez P, Okkenhaug H, Burton GJ, Moffett A, Turco MY, Hemberger M. Elife. 2021 Jun 25;10. pii: 63254. doi: 10.7554/eLife.63254. PubMed |
| Heparan Sulfate Facilitates Spike Protein-Mediated SARS-CoV-2 Host Cell Invasion and Contributes to Increased Infection of SARS-CoV-2 G614 Mutant and in Lung Cancer. Yue J, Jin W, Yang H, Faulkner J, Song X, Qiu H, Teng M, Azadi P, Zhang F, Linhardt RJ, Wang L. Front Mol Biosci. 2021 Jun 11;8:649575. doi: 10.3389/fmolb.2021.649575. eCollection 2021. PubMed |
| A flow cytometry-based assay for serological detection of anti-spike antibodies in COVID-19 patients. Goh YS, Ng LFP, Renia L. STAR Protoc. 2021 Sep 17;2(3):100671. doi: 10.1016/j.xpro.2021.100671. Epub 2021 Jun 19. PubMed |
| Low-Density Lipoprotein Receptor-Related Protein 6 Cell Surface Availability Regulates Fuel Metabolism in Astrocytes. Chow HM, Sun JK, Hart RP, Cheng KK, Hung CHL, Lau TM, Kwan KM. Adv Sci (Weinh). 2021 Aug;8(16):e2004993. doi: 10.1002/advs.202004993. Epub 2021 Jun 27. PubMed |
| Analysis of SAMHD1 Restriction by Flow Cytometry in Human Myeloid U937 Cells. Ordonez P, Bishop KN, Stoye JP, Groom HCT. J Vis Exp. 2021 Jun 13;(172). doi: 10.3791/62502. PubMed |
| The endogenous cellular protease inhibitor SPINT2 controls SARS-CoV-2 viral infection and is associated to disease severity. Ramirez Alvarez C, Kee C, Sharma AK, Thomas L, Schmidt FI, Stanifer ML, Boulant S, Herrmann C. PLoS Pathog. 2021 Jun 28;17(6):e1009687. doi: 10.1371/journal.ppat.1009687. eCollection 2021 Jun. PubMed |
Epitranscriptomic editing of the RNA N6-methyladenosine modification by dCasRx conjugated methyltransferase and demethylase.
Xia Z, Tang M, Ma J, Zhang H, Gimple RC, Prager BC, Tang H, Sun C, Liu F, Lin P, Mei Y, Du R, Rich JN, Xie Q.
Nucleic Acids Res. 2021 Jul 21;49(13):7361-7374. doi: 10.1093/nar/gkab517.
PubMed
Associated Plasmids |
| The long non-coding RNA betaFaar regulates islet beta-cell function and survival during obesity in mice. Zhang F, Yang Y, Chen X, Liu Y, Hu Q, Huang B, Liu Y, Pan Y, Zhang Y, Liu D, Liang R, Li G, Wei Q, Li L, Jin L. Nat Commun. 2021 Jun 28;12(1):3997. doi: 10.1038/s41467-021-24302-6. PubMed |
| Targeting Pyruvate Kinase M2 Phosphorylation Reverses Aggressive Cancer Phenotypes. Apostolidi M, Vathiotis IA, Muthusamy V, Gaule P, Gassaway BM, Rimm DL, Rinehart J. Cancer Res. 2021 Aug 15;81(16):4346-4359. doi: 10.1158/0008-5472.CAN-20-4190. Epub 2021 Jun 21. PubMed |
| Osmotic pressure modulates single cell cycle dynamics inducing reversible growth arrest and reactivation of human metastatic cells. Taieb HM, Garske DS, Contzen J, Gossen M, Bertinetti L, Robinson T, Cipitria A. Sci Rep. 2021 Jun 29;11(1):13455. doi: 10.1038/s41598-021-92054-w. PubMed |
| A T cell redirection platform for co-targeting dual antigens on solid tumors. Enderle L, Shalaby KH, Gorelik M, Weiss A, Blazer LL, Paduch M, Cardarelli L, Kossiakoff A, Adams JJ, Sidhu SS. MAbs. 2021 Jan-Dec;13(1):1933690. doi: 10.1080/19420862.2021.1933690. PubMed |
| Zika Virus Hijacks Extracellular Vesicle Tetraspanin Pathways for Cell-to-Cell Transmission. York SB, Sun L, Cone AS, Duke LC, Cheerathodi MR, Meckes DG Jr. mSphere. 2021 Jun 30:e0019221. doi: 10.1128/mSphere.00192-21. PubMed |
| Breast tumor stiffness instructs bone metastasis via maintenance of mechanical conditioning. Watson AW, Grant AD, Parker SS, Hill S, Whalen MB, Chakrabarti J, Harman MW, Roman MR, Forte BL, Gowan CC, Castro-Portuguez R, Stolze LK, Franck C, Cusanovich DA, Zavros Y, Padi M, Romanoski CE, Mouneimne G. Cell Rep. 2021 Jun 29;35(13):109293. doi: 10.1016/j.celrep.2021.109293. PubMed |
| Revealing molecular pathways for cancer cell fitness through a genetic screen of the cancer translatome. Kuzuoglu-Ozturk D, Hu Z, Rama M, Devericks E, Weiss J, Chiang GG, Worland ST, Brenner SE, Goodarzi H, Gilbert LA, Ruggero D. Cell Rep. 2021 Jun 29;35(13):109321. doi: 10.1016/j.celrep.2021.109321. PubMed |
| Shape of promoter antisense RNAs regulates ligand-induced transcription activation. Yang F, Tanasa B, Micheletti R, Ohgi KA, Aggarwal AK, Rosenfeld MG. Nature. 2021 Jul;595(7867):444-449. doi: 10.1038/s41586-021-03589-x. Epub 2021 Jun 30. PubMed |
| NADH Fluorescence Lifetime Imaging Microscopy Reveals Selective Mitochondrial Dysfunction in Neurons Overexpressing Alzheimer's Disease-Related Proteins. Niederschweiberer MA, Schaefer PM, Singh LN, Lausser L, Bhosale D, Hesse R, Calzia E, Kestler HA, Rueck A, Wallace DC, von Einem B, von Arnim CAF. Front Mol Biosci. 2021 Jun 14;8:671274. doi: 10.3389/fmolb.2021.671274. eCollection 2021. PubMed |
| CAR T cells targeting tumor-associated exons of glypican 2 regress neuroblastoma in mice. Li N, Torres MB, Spetz MR, Wang R, Peng L, Tian M, Dower CM, Nguyen R, Sun M, Tai CH, de Val N, Cachau R, Wu X, Hewitt SM, Kaplan RN, Khan J, St Croix B, Thiele CJ, Ho M. Cell Rep Med. 2021 Jun 1;2(6):100297. doi: 10.1016/j.xcrm.2021.100297. eCollection 2021 Jun 15. PubMed |
| How Cancer Cells Invade Bladder Epithelium and Form Tumors: The Mouse Bladder Tumor Model as a Model of Tumor Recurrence in Patients. Erman A, Kamensek U, Dragin Jerman U, Pavlin M, Cemazar M, Veranic P, Romih R. Int J Mol Sci. 2021 Jun 13;22(12). pii: ijms22126328. doi: 10.3390/ijms22126328. PubMed |
| Microtubule Acetylation Controls MDA-MB-231 Breast Cancer Cell Invasion through the Modulation of Endoplasmic Reticulum Stress. Ko P, Choi JH, Song S, Keum S, Jeong J, Hwang YE, Kim JW, Rhee S. Int J Mol Sci. 2021 Jun 2;22(11). pii: ijms22116018. doi: 10.3390/ijms22116018. PubMed |
| Overexpression of Replication-Dependent Histone Signifies a Subset of Dedifferentiated Liposarcoma with Increased Aggressiveness. Yoo Y, Park SY, Jo EB, Choi M, Lee KW, Hong D, Lee S, Lee CR, Lee Y, Um JY, Park JB, Seo SW, Choi YL, Kim S, Lee SG, Choi M. Cancers (Basel). 2021 Jun 22;13(13). pii: cancers13133122. doi: 10.3390/cancers13133122. PubMed |
| Concurrent mutations in RNA-dependent RNA polymerase and spike protein emerged as the epidemiologically most successful SARS-CoV-2 variant. Ilmjarv S, Abdul F, Acosta-Gutierrez S, Estarellas C, Galdadas I, Casimir M, Alessandrini M, Gervasio FL, Krause KH. Sci Rep. 2021 Jul 1;11(1):13705. doi: 10.1038/s41598-021-91662-w. PubMed |
| The RNA sensor MDA5 detects SARS-CoV-2 infection. Sampaio NG, Chauveau L, Hertzog J, Bridgeman A, Fowler G, Moonen JP, Dupont M, Russell RA, Noerenberg M, Rehwinkel J. Sci Rep. 2021 Jul 1;11(1):13638. doi: 10.1038/s41598-021-92940-3. PubMed |
| Acidic pH irreversibly activates the signaling enzyme SARM1. Zhao YJ, He WM, Zhao ZY, Li WH, Wang QW, Hou YN, Tan Y, Zhang D. FEBS J. 2021 Jul 2. doi: 10.1111/febs.16104. PubMed |
| Systematic analysis of SARS-CoV-2 infection of an ACE2-negative human airway cell. Puray-Chavez M, LaPak KM, Schrank TP, Elliott JL, Bhatt DP, Agajanian MJ, Jasuja R, Lawson DQ, Davis K, Rothlauf PW, Liu Z, Jo H, Lee N, Tenneti K, Eschbach JE, Shema Mugisha C, Cousins EM, Cloer EW, Vuong HR, VanBlargan LA, Bailey AL, Gilchuk P, Crowe JE Jr, Diamond MS, Hayes DN, Whelan SPJ, Horani A, Brody SL, Goldfarb D, Major MB, Kutluay SB. Cell Rep. 2021 Jul 13;36(2):109364. doi: 10.1016/j.celrep.2021.109364. Epub 2021 Jun 23. PubMed |
| Non-Structural Protein 5 of Zika Virus Interacts with p53 in Human Neural Progenitor Cells and Induces p53-Mediated Apoptosis. Li P, Jiang H, Peng H, Zeng W, Zhong Y, He M, Xie L, Chen J, Guo D, Wu J, Li CM. Virol Sin. 2021 Jul 5. pii: 10.1007/s12250-021-00422-7. doi: 10.1007/s12250-021-00422-7. PubMed |
| The proteolytic landscape of cells exposed to non-lethal stresses is shaped by executioner caspases. Conde-Rubio MDC, Mylonas R, Widmann C. Cell Death Discov. 2021 Jun 19;7(1):164. doi: 10.1038/s41420-021-00539-4. PubMed |
| Generation of CAR-T Cells by Lentiviral Transduction. Okuma A. Methods Mol Biol. 2021;2312:3-14. doi: 10.1007/978-1-0716-1441-9_1. PubMed |
| Active elimination of intestinal cells drives oncogenic growth in organoids. Krotenberg Garcia A, Fumagalli A, Le HQ, Jackstadt R, Lannagan TRM, Sansom OJ, van Rheenen J, Suijkerbuijk SJE. Cell Rep. 2021 Jul 6;36(1):109307. doi: 10.1016/j.celrep.2021.109307. PubMed |
| Regulation of NMDA receptor trafficking and gating by activity-dependent CaMKIIalpha phosphorylation of the GluN2A subunit. Yong XLH, Zhang L, Yang L, Chen X, Tan JZA, Yu X, Chandra M, Livingstone E, Widagdo J, Vieira MM, Roche KW, Lynch JW, Keramidas A, Collins BM, Anggono V. Cell Rep. 2021 Jul 6;36(1):109338. doi: 10.1016/j.celrep.2021.109338. PubMed |
| The Mediator subunit MED20 organizes the early adipogenic complex to promote development of adipose tissues and diet-induced obesity. Tang WS, Weng L, Wang X, Liu CQ, Hu GS, Yin ST, Tao Y, Hong NN, Guo H, Liu W, Wang HR, Zhao TJ. Cell Rep. 2021 Jul 6;36(1):109314. doi: 10.1016/j.celrep.2021.109314. PubMed |
| The site of breast cancer metastases dictates their clonal composition and reversible transcriptomic profile. Berthelet J, Wimmer VC, Whitfield HJ, Serrano A, Boudier T, Mangiola S, Merdas M, El-Saafin F, Baloyan D, Wilcox J, Wilcox S, Parslow AC, Papenfuss AT, Yeo B, Ernst M, Pal B, Anderson RL, Davis MJ, Rogers KL, Hollande F, Merino D. Sci Adv. 2021 Jul 7;7(28). pii: 7/28/eabf4408. doi: 10.1126/sciadv.abf4408. Print 2021 Jul. PubMed |
| Prognostic role and biologic features of Musashi-2 expression in colon polyps and during colorectal cancer progression. Kharin L, Bychkov I, Karnaukhov N, Voloshin M, Fazliyeva R, Deneka A, Frantsiyants E, Kit O, Golemis E, Boumber Y. PLoS One. 2021 Jul 8;16(7):e0252132. doi: 10.1371/journal.pone.0252132. eCollection 2021. PubMed |
| The multi-functional reovirus sigma3 protein is a virulence factor that suppresses stress granule formation and is associated with myocardial injury. Guo Y, Hinchman MM, Lewandrowski M, Cross ST, Sutherland DM, Welsh OL, Dermody TS, Parker JSL. PLoS Pathog. 2021 Jul 8;17(7):e1009494. doi: 10.1371/journal.ppat.1009494. eCollection 2021 Jul. PubMed |
| The RAS GTPase RIT1 compromises mitotic fidelity through spindle assembly checkpoint suppression. Cuevas-Navarro A, Van R, Cheng A, Urisman A, Castel P, McCormick F. Curr Biol. 2021 Sep 13;31(17):3915-3924.e9. doi: 10.1016/j.cub.2021.06.030. Epub 2021 Jul 7. PubMed |
| PIAS1 potentiates the anti-EBV activity of SAMHD1 through SUMOylation. Saiada F, Zhang K, Li R. Cell Biosci. 2021 Jul 8;11(1):127. doi: 10.1186/s13578-021-00636-y. PubMed |
| lncRNA GAU1 Induces GALNT8 Overexpression and Potentiates Colorectal Cancer Progression. Tang X, Ruan H, Dong L, Li S, Wu Z, Guan M. Gastroenterol Res Pract. 2021 Jun 17;2021:5960821. doi: 10.1155/2021/5960821. eCollection 2021. PubMed |
| ARHGEF26 enhances Salmonella invasion and inflammation in cells and mice. Bourgeois JS, Wang L, Rabino AF, Everitt J, Alvarez MI, Awadia S, Wittchen ES, Garcia-Mata R, Ko DC. PLoS Pathog. 2021 Jul 9;17(7):e1009713. doi: 10.1371/journal.ppat.1009713. eCollection 2021 Jul. PubMed |
| The fluid shear stress sensor TRPM7 regulates tumor cell intravasation. Yankaskas CL, Bera K, Stoletov K, Serra SA, Carrillo-Garcia J, Tuntithavornwat S, Mistriotis P, Lewis JD, Valverde MA, Konstantopoulos K. Sci Adv. 2021 Jul 9;7(28). pii: 7/28/eabh3457. doi: 10.1126/sciadv.abh3457. Print 2021 Jul. PubMed |
| Cholesterol auxotrophy as a targetable vulnerability in clear cell renal cell carcinoma. Riscal R, Bull CJ, Mesaros C, Finan JM, Carens M, Ho ES, Xu JP, Godfrey J, Brennan P, Johansson M, Purdue MP, Chanock SJ, Mariosa D, Timpson NJ, Vincent EE, Keith B, Blair IA, Skuli N, Simon MC. Cancer Discov. 2021 Jul 8. pii: 2159-8290.CD-21-0211. doi: 10.1158/2159-8290.CD-21-0211. PubMed |
| TMEM97 ablation aggravates oxidant-induced retinal degeneration. Shen H, Li J, Heisler-Taylor T, Makin R, Yang H, Mavlyutov TA, Gelfand B, Cebulla CM, Guo LW. Cell Signal. 2021 Oct;86:110078. doi: 10.1016/j.cellsig.2021.110078. Epub 2021 Jul 7. PubMed |
| Single-Cell Analyses Reveal Diverse Mechanisms of Resistance to EGFR Tyrosine Kinase Inhibitors in Lung Cancer. Kashima Y, Shibahara D, Suzuki A, Muto K, Kobayashi IS, Plotnick D, Udagawa H, Izumi H, Shibata Y, Tanaka K, Fujii M, Ohashi A, Seki M, Goto K, Tsuchihara K, Suzuki Y, Kobayashi SS. Cancer Res. 2021 Sep 15;81(18):4835-4848. doi: 10.1158/0008-5472.CAN-20-2811. Epub 2021 Jul 9. PubMed |
| CD3G or CD3D Knockdown in Mature, but Not Immature, T Lymphocytes Similarly Cripples the Human TCRalphabeta Complex. Garcillan B, Fuentes P, Marin AV, Megino RF, Chacon-Arguedas D, Mazariegos MS, Jimenez-Reinoso A, Munoz-Ruiz M, Laborda RG, Cardenas PP, Fernandez-Malave E, Toribio ML, Regueiro JR. Front Cell Dev Biol. 2021 Jun 25;9:608490. doi: 10.3389/fcell.2021.608490. eCollection 2021. PubMed |
| MicroRNA-324-5p-CUEDC2 Axis Mediates Gain-of-Function Mutant p53-Driven Cancer Stemness. Ghatak D, Datta A, Roychowdhury T, Chattopadhyay S, Roychoudhury S. Mol Cancer Res. 2021 Jul 13. pii: 1541-7786.MCR-20-0717. doi: 10.1158/1541-7786.MCR-20-0717. PubMed |
| circFAT1 Promotes Cancer Stemness and Immune Evasion by Promoting STAT3 Activation. Jia L, Wang Y, Wang CY. Adv Sci (Weinh). 2021 May 2;8(13):2003376. doi: 10.1002/advs.202003376. eCollection 2021 Jul. PubMed |
| Advancing a rapid, high throughput screening platform for optimization of lentivirus production. Gopal S, Osborne AE, Hock L, Zemianek J, Fang K, Gee G, Ghosh R, McNally D, Cramer SM, Dordick JS. Biotechnol J. 2021 Jul 14:e2000621. doi: 10.1002/biot.202000621. PubMed |
| The long noncoding RNA HOTAIRM1 controlled by AML1 enhances glucocorticoid resistance by activating RHOA/ROCK1 pathway through suppressing ARHGAP18. Liang L, Gu W, Li M, Gao R, Zhang X, Guo C, Mi S. Cell Death Dis. 2021 Jul 14;12(7):702. doi: 10.1038/s41419-021-03982-4. PubMed |
| Large parental differences in chromatin organization in pancreatic beta cell line explaining diabetes susceptibility effects. Jian X, Felsenfeld G. Nat Commun. 2021 Jul 15;12(1):4338. doi: 10.1038/s41467-021-24635-2. PubMed |
| Squalene epoxidase promotes colorectal cancer cell proliferation through accumulating calcitriol and activating CYP24A1-mediated MAPK signaling. He L, Li H, Pan C, Hua Y, Peng J, Zhou Z, Zhao Y, Lin M. Cancer Commun (Lond). 2021 Aug;41(8):726-746. doi: 10.1002/cac2.12187. Epub 2021 Jul 16. PubMed |
Mutants of human ACE2 differentially promote SARS-CoV and SARS-CoV-2 spike mediated infection.
Shukla N, Roelle SM, Suzart VG, Bruchez AM, Matreyek KA.
PLoS Pathog. 2021 Jul 16;17(7):e1009715. doi: 10.1371/journal.ppat.1009715. eCollection 2021 Jul.
PubMed
Associated Plasmids |
| Glycerol-3-phosphate biosynthesis regenerates cytosolic NAD(+) to alleviate mitochondrial disease. Liu S, Fu S, Wang G, Cao Y, Li L, Li X, Yang J, Li N, Shan Y, Cao Y, Ma Y, Dong M, Liu Q, Jiang H. Cell Metab. 2021 Jul 8. pii: S1550-4131(21)00283-7. doi: 10.1016/j.cmet.2021.06.013. PubMed |
| Mutation in FBXO32 causes dilated cardiomyopathy through up-regulation of ER-stress mediated apoptosis. Al-Yacoub N, Colak D, Mahmoud SA, Hammonds M, Muhammed K, Al-Harazi O, Assiri AM, Al-Buraiki J, Al-Habeeb W, Poizat C. Commun Biol. 2021 Jul 16;4(1):884. doi: 10.1038/s42003-021-02391-9. PubMed |
| Astragaloside IV ameliorates diabetic nephropathy in db/db mice by inhibiting NLRP3 inflammasomemediated inflammation. Feng H, Zhu X, Tang Y, Fu S, Kong B, Liu X. Int J Mol Med. 2021 Aug;48(2). pii: 164. doi: 10.3892/ijmm.2021.4996. Epub 2021 Jul 19. PubMed |
| BTK inhibition sensitizes Acute Lymphoblastic Leukemia to asparaginase by suppressing the Amino Acid Response pathway. Butler M, van Ingen Schenau DS, Yu J, Jenni S, Dobay MP, Hagelaar R, Vervoort BMT, Tee TM, Hoff FW, Meijerink JP, Kornblau SM, Bornhauser B, Bourquin JP, Kuiper RP, van der Meer LT, van Leeuwen FN. Blood. 2021 Jul 19. pii: S0006-4971(21)01372-0. doi: 10.1182/blood.2021011787. PubMed |
| Imbalanced autophagy causes synaptic deficits in a human model for neurodevelopmental disorders. Linda K, Lewerissa EI, Verboven AHA, Gabriele M, Frega M, Klein Gunnewiek TM, Devilee L, Ulferts E, Hommersom M, Oudakker A, Schoenmaker C, van Bokhoven H, Schubert D, Testa G, Koolen DA, de Vries BBA, Nadif Kasri N. Autophagy. 2022 Feb;18(2):423-442. doi: 10.1080/15548627.2021.1936777. Epub 2021 Jul 21. PubMed |
| Structural Determinants of Virion Assembly and Release in the C Terminus of the Mason-Pfizer Monkey Virus Capsid Protein. Buckmaster MV, Zadrozny KK, Ganser-Pornillos BK, Pornillos O, Goff SP. J Virol. 2021 Sep 9;95(19):e0061521. doi: 10.1128/JVI.00615-21. Epub 2021 Jul 21. PubMed |
| LncRNA PVT1 promotes the progression of ovarian cancer by activating TGF-beta pathway via miR-148a-3p/AGO1 axis. Wu Y, Gu W, Han X, Jin Z. J Cell Mol Med. 2021 Sep;25(17):8229-8243. doi: 10.1111/jcmm.16700. Epub 2021 Jul 21. PubMed |
| Cytokine-induced apoptosis inhibitor 1 (CIAPIN1) accelerates vascular remodelling via p53 and JAK2-STAT3 regulation in vascular smooth muscle cells. Han JH, Heo KS, Myung CS. Br J Pharmacol. 2021 Jul 21. doi: 10.1111/bph.15631. PubMed |
| CD19/CD22 Dual-Targeted CAR T-cell Therapy for Relapsed/Refractory Aggressive B-cell Lymphoma: A Safety and Efficacy Study. Wei G, Zhang Y, Zhao H, Wang Y, Liu Y, Liang B, Wang X, Xu H, Cui J, Wu W, Zhao K, Nagler A, Chang AH, Hu Y, Huang H. Cancer Immunol Res. 2021 Sep;9(9):1061-1070. doi: 10.1158/2326-6066.CIR-20-0675. Epub 2021 Jul 21. PubMed |
| Nuclear NAD(+) homeostasis governed by NMNAT1 prevents apoptosis of acute myeloid leukemia stem cells. Shi X, Jiang Y, Kitano A, Hu T, Murdaugh RL, Li Y, Hoegenauer KA, Chen R, Takahashi K, Nakada D. Sci Adv. 2021 Jul 21;7(30). pii: 7/30/eabf3895. doi: 10.1126/sciadv.abf3895. Print 2021 Jul. PubMed |
| Machine learning approach for discrimination of genotypes based on bright-field cellular images. Suzuki G, Saito Y, Seki M, Evans-Yamamoto D, Negishi M, Kakoi K, Kawai H, Landry CR, Yachie N, Mitsuyama T. NPJ Syst Biol Appl. 2021 Jul 21;7(1):31. doi: 10.1038/s41540-021-00190-w. PubMed |
| Liposome-mediated detection of SARS-CoV-2 RNA-positive extracellular vesicles in plasma. Ning B, Huang Z, Youngquist BM, Scott JW, Niu A, Bojanowski CM, Zwezdaryk KJ, Saba NS, Fan J, Yin XM, Cao J, Lyon CJ, Li CZ, Roy CJ, Hu TY. Nat Nanotechnol. 2021 Sep;16(9):1039-1044. doi: 10.1038/s41565-021-00939-8. Epub 2021 Jul 22. PubMed |
| Lysine demethylase KDM6B regulates HIF-1alpha-mediated systemic and cellular responses to intermittent hypoxia. Nanduri J, Wang N, Wang BL, Prabhakar NR. Physiol Genomics. 2021 Sep 1;53(9):385-394. doi: 10.1152/physiolgenomics.00045.2021. Epub 2021 Jul 23. PubMed |
| A conserved ubiquitin- and ESCRT-dependent pathway internalizes human lysosomal membrane proteins for degradation. Zhang W, Yang X, Chen L, Liu YY, Venkatarangan V, Reist L, Hanson P, Xu H, Wang Y, Li M. PLoS Biol. 2021 Jul 23;19(7):e3001361. doi: 10.1371/journal.pbio.3001361. eCollection 2021 Jul. PubMed |
| Single-cell analysis defines a pancreatic fibroblast lineage that supports anti-tumor immunity. Hutton C, Heider F, Blanco-Gomez A, Banyard A, Kononov A, Zhang X, Karim S, Paulus-Hock V, Watt D, Steele N, Kemp S, Hogg EKJ, Kelly J, Jackstadt RF, Lopes F, Menotti M, Chisholm L, Lamarca A, Valle J, Sansom OJ, Springer C, Malliri A, Marais R, Pasca di Magliano M, Zelenay S, Morton JP, Jorgensen C. Cancer Cell. 2021 Sep 13;39(9):1227-1244.e20. doi: 10.1016/j.ccell.2021.06.017. Epub 2021 Jul 22. PubMed |
| Phosphorylation of H3-Thr3 by Haspin Is Required for Primary Cilia Regulation. Quadri R, Sertic S, Ghilardi A, Rondelli D, Gallo GR, Del Giacco L, Muzi-Falconi M. Int J Mol Sci. 2021 Jul 20;22(14). pii: ijms22147753. doi: 10.3390/ijms22147753. PubMed |
| YAP1 nuclear efflux and transcriptional reprograming follow membrane diminution upon VSV-G-induced cell fusion. Feliciano D, Ott CM, Espinosa-Medina I, Weigel AV, Benedetti L, Milano KM, Tang Z, Lee T, Kliman HJ, Guller SM, Lippincott-Schwartz J. Nat Commun. 2021 Jul 23;12(1):4502. doi: 10.1038/s41467-021-24708-2. PubMed |
| Deacetylation as a receptor-regulated direct activation switch for pannexin channels. Chiu YH, Medina CB, Doyle CA, Zhou M, Narahari AK, Sandilos JK, Gonye EC, Gao HY, Guo SY, Parlak M, Lorenz UM, Conrads TP, Desai BN, Ravichandran KS, Bayliss DA. Nat Commun. 2021 Jul 23;12(1):4482. doi: 10.1038/s41467-021-24825-y. PubMed |
| Human cell transformation by combined lineage conversion and oncogene expression. Sahu B, Pihlajamaa P, Zhang K, Palin K, Ahonen S, Cervera A, Ristimaki A, Aaltonen LA, Hautaniemi S, Taipale J. Oncogene. 2021 Sep;40(36):5533-5547. doi: 10.1038/s41388-021-01940-0. Epub 2021 Jul 23. PubMed |
| CRISPRi/a Screening with Human iPSCs. Nishiga M, Qi LS, Wu JC. Methods Mol Biol. 2021;2320:261-281. doi: 10.1007/978-1-0716-1484-6_23. PubMed |
| A Structural Study of the Cytoplasmic Chaperone Effect of 14-3-3 Proteins on Ataxin-1. Leysen S, Burnley RJ, Rodriguez E, Milroy LG, Soini L, Adamski CJ, Nitschke L, Davis R, Obsil T, Brunsveld L, Crabbe T, Zoghbi HY, Ottmann C, Davis JM. J Mol Biol. 2021 Sep 17;433(19):167174. doi: 10.1016/j.jmb.2021.167174. Epub 2021 Jul 21. PubMed |
| A human cell-based SARS-CoV-2 vaccine elicits potent neutralizing antibody responses and protects mice from SARS-CoV-2 challenge. He X, Ding L, Cao K, Peng H, Gu C, Li Y, Li D, Dong L, Hong X, Wang X, Fu M, Qiu C, Zhu C, Zhang Z, Song S, Wang C, Jiang Z, Xie Y, Qi Z, Zhao C, Zhao P, Zhang X, Xu J. Emerg Microbes Infect. 2021 Dec;10(1):1555-1573. doi: 10.1080/22221751.2021.1957400. PubMed |
| Condensation of pericentrin proteins in human cells illuminates phase separation in centrosome assembly. Jiang X, Ho DBT, Mahe K, Mia J, Sepulveda G, Antkowiak M, Jiang L, Yamada S, Jao LE. J Cell Sci. 2021 Jul 15;134(14). pii: 271045. doi: 10.1242/jcs.258897. Epub 2021 Jul 26. PubMed |
| Zinc finger antiviral protein (ZAP) inhibits small ruminant morbillivirus replication in vitro. Tang A, Tang J, Miao Q, Zhu J, Guo H, Liu C, Meng C, Li C, Chen Z, Liu G. Vet Microbiol. 2021 Sep;260:109163. doi: 10.1016/j.vetmic.2021.109163. Epub 2021 Jun 23. PubMed |
| Molecular Imaging Reveals a High Degree of Cross-Seeding of Spontaneous Metastases in a Novel Mouse Model of Synchronous Bilateral Breast Cancer. Liu S, Nystrom NN, Kelly JJ, Hamilton AM, Fu Y, Ronald JA. Mol Imaging Biol. 2021 Jul 26. pii: 10.1007/s11307-021-01630-z. doi: 10.1007/s11307-021-01630-z. PubMed |
| An autoimmune disease risk variant: A trans master regulatory effect mediated by IRF1 under immune stimulation? Brandt M, Kim-Hellmuth S, Ziosi M, Gokden A, Wolman A, Lam N, Recinos Y, Daniloski Z, Morris JA, Hornung V, Schumacher J, Lappalainen T. PLoS Genet. 2021 Jul 27;17(7):e1009684. doi: 10.1371/journal.pgen.1009684. eCollection 2021 Jul. PubMed |
| CD97 stabilises the immunological synapse between dendritic cells and T cells and is targeted for degradation by the Salmonella effector SteD. Cerny O, Godlee C, Tocci R, Cross NE, Shi H, Williamson JC, Alix E, Lehner PJ, Holden DW. PLoS Pathog. 2021 Jul 27;17(7):e1009771. doi: 10.1371/journal.ppat.1009771. eCollection 2021 Jul. PubMed |
| The Cancer Therapy-Related Clonal Hematopoiesis Driver Gene Ppm1d Promotes Inflammation and Non-Ischemic Heart Failure in Mice. Yura Y, Miura-Yura E, Katanasaka Y, Min KD, Chavkin N, Polizio AH, Ogawa H, Horitani K, Doviak H, Evans MA, Sano M, Wang Y, Boroviak K, Philippos G, Domingues AF, Vassiliou G, Sano S, Walsh K. Circ Res. 2021 Sep 3;129(6):684-698. doi: 10.1161/CIRCRESAHA.121.319314. Epub 2021 Jul 28. PubMed |
| Galphaq activation modulates autophagy by promoting mTORC1 signaling. Cabezudo S, Sanz-Flores M, Caballero A, Tasset I, Rebollo E, Diaz A, Aragay AM, Cuervo AM, Mayor F Jr, Ribas C. Nat Commun. 2021 Jul 27;12(1):4540. doi: 10.1038/s41467-021-24811-4. PubMed |
PALI1 facilitates DNA and nucleosome binding by PRC2 and triggers an allosteric activation of catalysis.
Zhang Q, Agius SC, Flanigan SF, Uckelmann M, Levina V, Owen BM, Davidovich C.
Nat Commun. 2021 Jul 28;12(1):4592. doi: 10.1038/s41467-021-24866-3.
PubMed
Associated Plasmids |
A plug-and-play platform of ratiometric bioluminescent sensors for homogeneous immunoassays.
Ni Y, Rosier BJHM, van Aalen EA, Hanckmann ETL, Biewenga L, Pistikou AM, Timmermans B, Vu C, Roos S, Arts R, Li W, de Greef TFA, van Borren MMGJ, van Kuppeveld FJM, Bosch BJ, Merkx M.
Nat Commun. 2021 Jul 28;12(1):4586. doi: 10.1038/s41467-021-24874-3.
PubMed
Associated Plasmids |
| Inhibition of Janus Kinase 1 synergizes docetaxel sensitivity in prostate cancer cells. Nalairndran G, Chung I, Abdul Razack AH, Chung FF, Hii LW, Lim WM, Looi CK, Mai CW, Leong CO. J Cell Mol Med. 2021 Sep;25(17):8187-8200. doi: 10.1111/jcmm.16684. Epub 2021 Jul 28. PubMed |
| Isolation and Neuronal Reprogramming of Mouse Embryonic Fibroblasts. Adrian-Segarra JM, Weigel B, Mall M. Methods Mol Biol. 2021;2352:1-12. doi: 10.1007/978-1-0716-1601-7_1. PubMed |
| Direct Cell Reprogramming of Mouse Fibroblasts into Functional Astrocytes Using Lentiviral Overexpression of the Transcription Factors NFIA, NFIB, and SOX9. Qiu B, de Vries RJ, Caiazzo M. Methods Mol Biol. 2021;2352:31-43. doi: 10.1007/978-1-0716-1601-7_3. PubMed |
| Direct Conversion of Human Fibroblasts to Induced Neurons. Zhou-Yang L, Eichhorner S, Karbacher L, Bohnke L, Traxler L, Mertens J. Methods Mol Biol. 2021;2352:73-96. doi: 10.1007/978-1-0716-1601-7_6. PubMed |
| Direct Differentiation of Functional Neurons from Human Pluripotent Stem Cells (hPSCs). Hu R, Zhu X, Yang N. Methods Mol Biol. 2021;2352:117-126. doi: 10.1007/978-1-0716-1601-7_8. PubMed |
| Transcription Factor Programming of Human Pluripotent Stem Cells to Functionally Mature Astrocytes for Monocultures and Cocultures with Neurons. Quist E, Ahlenius H, Canals I. Methods Mol Biol. 2021;2352:133-148. doi: 10.1007/978-1-0716-1601-7_10. PubMed |
| Single Transcription Factor-Based Differentiation Allowing Fast and Efficient Oligodendrocyte Generation via SOX10 Overexpression. Neyrinck K, Garcia-Leon JA. Methods Mol Biol. 2021;2352:149-170. doi: 10.1007/978-1-0716-1601-7_11. PubMed |
| Functional Assessment of Direct Reprogrammed Neurons In Vitro and In Vivo. Kidnapillai S, Ottosson DR. Methods Mol Biol. 2021;2352:183-199. doi: 10.1007/978-1-0716-1601-7_13. PubMed |
| N6-methyladenosine promotes induction of ADAR1-mediated A-to-I RNA editing to suppress aberrant antiviral innate immune responses. Terajima H, Lu M, Zhang L, Cui Q, Shi Y, Li J, He C. PLoS Biol. 2021 Jul 29;19(7):e3001292. doi: 10.1371/journal.pbio.3001292. eCollection 2021 Jul. PubMed |
| Small molecule inhibition of deubiquitinating enzyme JOSD1 as a novel targeted therapy for leukemias with mutant JAK2. Yang J, Weisberg EL, Liu X, Magin RS, Chan WC, Hu B, Schauer NJ, Zhang S, Lamberto I, Doherty L, Meng C, Sattler M, Cabal-Hierro L, Winer E, Stone R, Marto JA, Griffin JD, Buhrlage SJ. Leukemia. 2022 Jan;36(1):210-220. doi: 10.1038/s41375-021-01336-9. Epub 2021 Jul 29. PubMed |
| Allo-Specific Humoral Responses: New Methods for Screening Donor-Specific Antibody and Characterization of HLA-Specific Memory B Cells. Song S, Manook M, Kwun J, Jackson AM, Knechtle SJ, Kelsoe G. Front Immunol. 2021 Jul 13;12:705140. doi: 10.3389/fimmu.2021.705140. eCollection 2021. PubMed |
| AKT3-mediated IWS1 phosphorylation promotes the proliferation of EGFR-mutant lung adenocarcinomas through cell cycle-regulated U2AF2 RNA splicing. Laliotis GI, Chavdoula E, Paraskevopoulou MD, Kaba A, La Ferlita A, Singh S, Anastas V, Nair KA 2nd, Orlacchio A, Taraslia V, Vlachos I, Capece M, Hatzigeorgiou A, Palmieri D, Tsatsanis C, Alaimo S, Sehgal L, Carbone DP, Coppola V, Tsichlis PN. Nat Commun. 2021 Jul 30;12(1):4624. doi: 10.1038/s41467-021-24795-1. PubMed |
| PRMT1-dependent regulation of RNA metabolism and DNA damage response sustains pancreatic ductal adenocarcinoma. Giuliani V, Miller MA, Liu CY, Hartono SR, Class CA, Bristow CA, Suzuki E, Sanz LA, Gao G, Gay JP, Feng N, Rose JL, Tomihara H, Daniele JR, Peoples MD, Bardenhagen JP, Geck Do MK, Chang QE, Vangamudi B, Vellano C, Ying H, Deem AK, Do KA, Genovese G, Marszalek JR, Kovacs JJ, Kim M, Fleming JB, Guccione E, Viale A, Maitra A, Emilia Di Francesco M, Yap TA, Jones P, Draetta G, Carugo A, Chedin F, Heffernan TP. Nat Commun. 2021 Jul 30;12(1):4626. doi: 10.1038/s41467-021-24798-y. PubMed |
| Elevated LINC00909 Promotes Tumor Progression of Ovarian Cancer via Regulating the miR-23b-3p/MRC2 Axis. Yang X, Wu G, Yang F, He L, Xie X, Li L, Yang L, Ma Y, Zhang Q, Chen J, Zou S, Han Q, Wang Y, Liu S, Li J, Han B, Liu K. Oxid Med Cell Longev. 2021 Jul 21;2021:5574130. doi: 10.1155/2021/5574130. eCollection 2021. PubMed |
| Identification of response signatures for tankyrase inhibitor treatment in tumor cell lines. Mygland L, Brinch SA, Strand MF, Olsen PA, Aizenshtadt A, Lund K, Solberg NT, Lycke M, Thorvaldsen TE, Espada S, Misaghian D, Page CM, Agafonov O, Nygard S, Chi NW, Lin E, Tan J, Yu Y, Costa M, Krauss S, Waaler J. iScience. 2021 Jul 1;24(7):102807. doi: 10.1016/j.isci.2021.102807. eCollection 2021 Jul 23. PubMed |
| STING1 is essential for an RNA-virus triggered autophagy. Zhang R, Qin X, Yang Y, Zhu X, Zhao S, Zhang Z, Su Q, Zhao Z, Yin X, Meng X, Zhang Z, Li Y. Autophagy. 2022 Apr;18(4):816-828. doi: 10.1080/15548627.2021.1959086. Epub 2021 Aug 2. PubMed |
| The Mammalian Membrane Microenvironment Regulates the Sequential Attachment of Bacteria to Host Cells. Pierrat X, Wong JPH, Al-Mayyah Z, Persat A. mBio. 2021 Aug 31;12(4):e0139221. doi: 10.1128/mBio.01392-21. Epub 2021 Aug 3. PubMed |
| Nkx6.1 enhances neural stem cell activation and attenuates glial scar formation and neuroinflammation in the adult injured spinal cord. Patel M, Anderson J, Lei S, Finkel Z, Rodriguez B, Esteban F, Risman R, Li Y, Lee KB, Lyu YL, Cai L. Exp Neurol. 2021 Nov;345:113826. doi: 10.1016/j.expneurol.2021.113826. Epub 2021 Jul 31. PubMed |
| Mammalian acetate-dependent acetyl CoA synthetase 2 contains multiple protein destabilization and masking elements. Nagati JS, Kobeissy PH, Nguyen MQ, Xu M, Garcia T, Comerford SA, Hammer RE, Garcia JA. J Biol Chem. 2021 Sep;297(3):101037. doi: 10.1016/j.jbc.2021.101037. Epub 2021 Jul 31. PubMed |
| Phosphorylated cingulin localises GEF-H1 at tight junctions to protect vascular barriers in blood endothelial cells. Holzner S, Bromberger S, Wenzina J, Neumuller K, Holper TM, Petzelbauer P, Bauer W, Weber B, Schossleitner K. J Cell Sci. 2021 Sep 1;134(17). pii: 271985. doi: 10.1242/jcs.258557. Epub 2021 Sep 2. PubMed |
| CD13 orients the apical-basal polarity axis necessary for lumen formation. Wang LT, Rajah A, Brown CM, McCaffrey L. Nat Commun. 2021 Aug 4;12(1):4697. doi: 10.1038/s41467-021-24993-x. PubMed |
| Alternol triggers immunogenic cell death via reactive oxygen species generation. Li C, Zhang Y, Yan S, Zhang G, Wei W, Qi Z, Li B. Oncoimmunology. 2021 Jul 21;10(1):1952539. doi: 10.1080/2162402X.2021.1952539. eCollection 2021. PubMed |
| Ubiquitin-Like Protein UBD Promotes Cell Proliferation in Colorectal Cancer by Facilitating p53 Degradation. Su H, Qin M, Liu Q, Jin B, Shi X, Xiang Z. Front Oncol. 2021 Jul 14;11:691347. doi: 10.3389/fonc.2021.691347. eCollection 2021. PubMed |
| The biochemical basis of mitochondrial dysfunction in Zellweger Spectrum Disorder. Nuebel E, Morgan JT, Fogarty S, Winter JM, Lettlova S, Berg JA, Chen YC, Kidwell CU, Maschek JA, Clowers KJ, Argyriou C, Chen L, Wittig I, Cox JE, Roh-Johnson M, Braverman N, Bonkowsky J, Gygi SP, Rutter J. EMBO Rep. 2021 Oct 5;22(10):e51991. doi: 10.15252/embr.202051991. Epub 2021 Aug 5. PubMed |
| Responsiveness to perturbations is a hallmark of transcription factors that maintain cell identity in vitro. Mellis IA, Edelstein HI, Truitt R, Goyal Y, Beck LE, Symmons O, Dunagin MC, Linares Saldana RA, Shah PP, Perez-Bermejo JA, Padmanabhan A, Yang W, Jain R, Raj A. Cell Syst. 2021 Sep 22;12(9):885-899.e8. doi: 10.1016/j.cels.2021.07.003. Epub 2021 Aug 4. PubMed |
| ERAD components Derlin-1 and Derlin-2 are essential for postnatal brain development and motor function. Sugiyama T, Murao N, Kadowaki H, Takao K, Miyakawa T, Matsushita Y, Katagiri T, Futatsugi A, Shinmyo Y, Kawasaki H, Sakai J, Shiomi K, Nakazato M, Takeda K, Mikoshiba K, Ploegh HL, Ichijo H, Nishitoh H. iScience. 2021 Jun 19;24(7):102758. doi: 10.1016/j.isci.2021.102758. eCollection 2021 Jul 23. PubMed |
| LncRNA AERRIE Is Required for Sulfatase 1 Expression, but Not for Endothelial-to-Mesenchymal Transition. Pham TP, van Bergen AS, Kremer V, Glaser SF, Dimmeler S, Boon RA. Int J Mol Sci. 2021 Jul 28;22(15). pii: ijms22158088. doi: 10.3390/ijms22158088. PubMed |
| The stressosome, a caspase-8-activating signalling complex assembled in response to cell stress in an ATG5-mediated manner. Mnich K, Koryga I, Pakos-Zebrucka K, Thomas M, Logue SE, Eriksson LA, Gorman AM, Samali A. J Cell Mol Med. 2021 Sep;25(18):8809-8820. doi: 10.1111/jcmm.16840. Epub 2021 Aug 7. PubMed |
| BioID reveals an ATG9A interaction with ATG13-ATG101 in the degradation of p62/SQSTM1-ubiquitin clusters. Kannangara AR, Poole DM, McEwan CM, Youngs JC, Weerasekara VK, Thornock AM, Lazaro MT, Balasooriya ER, Oh LM, Soderblom EJ, Lee JJ, Simmons DL, Andersen JL. EMBO Rep. 2021 Aug 9:e51136. doi: 10.15252/embr.202051136. PubMed |
| Activation of bivalent factor DLX5 cooperates with master regulator TP63 to promote squamous cell carcinoma. Huang Y, Yang Q, Zheng Y, Lin L, Xu X, Xu XE, Silva TC, Hazawa M, Peng L, Cao H, Ding Y, Lu D, Berman BP, Xu LY, Li EM, Yin D. Nucleic Acids Res. 2021 Sep 20;49(16):9246-9263. doi: 10.1093/nar/gkab679. PubMed |
| AHR mediates the aflatoxin B1 toxicity associated with hepatocellular carcinoma. Zhu Q, Ma Y, Liang J, Wei Z, Li M, Zhang Y, Liu M, He H, Qu C, Cai J, Wang X, Zeng Y, Jiao Y. Signal Transduct Target Ther. 2021 Aug 9;6(1):299. doi: 10.1038/s41392-021-00713-1. PubMed |
| Acquired JAK2 mutations confer resistance to JAK inhibitors in cell models of acute lymphoblastic leukemia. Downes CEJ, McClure BJ, Bruning JB, Page E, Breen J, Rehn J, Yeung DT, White DL. NPJ Precis Oncol. 2021 Aug 10;5(1):75. doi: 10.1038/s41698-021-00215-x. PubMed |
| GOT1 inhibition promotes pancreatic cancer cell death by ferroptosis. Kremer DM, Nelson BS, Lin L, Yarosz EL, Halbrook CJ, Kerk SA, Sajjakulnukit P, Myers A, Thurston G, Hou SW, Carpenter ES, Andren AC, Nwosu ZC, Cusmano N, Wisner S, Mbah NE, Shan M, Das NK, Magnuson B, Little AC, Savani MR, Ramos J, Gao T, Sastra SA, Palermo CF, Badgley MA, Zhang L, Asara JM, McBrayer SK, di Magliano MP, Crawford HC, Shah YM, Olive KP, Lyssiotis CA. Nat Commun. 2021 Aug 11;12(1):4860. doi: 10.1038/s41467-021-24859-2. PubMed |
| USP12 downregulation orchestrates a protumourigenic microenvironment and enhances lung tumour resistance to PD-1 blockade. Yang Z, Xu G, Wang B, Liu Y, Zhang L, Jing T, Tang M, Xu X, Jiao K, Xiang L, Fu Y, Tang D, Zhang X, Jin W, Zhuang G, Zhao X, Liu Y. Nat Commun. 2021 Aug 11;12(1):4852. doi: 10.1038/s41467-021-25032-5. PubMed |
| Loss of grand histone H3 lysine 27 trimethylation domains mediated transcriptional activation in esophageal squamous cell carcinoma. Yuan J, Jiang Q, Gong T, Fan D, Zhang J, Chen F, Zhu X, Wang X, Qiao Y, Chen H, Liu Z, Su J. NPJ Genom Med. 2021 Aug 11;6(1):65. doi: 10.1038/s41525-021-00232-6. PubMed |
| Export of RNA-derived modified nucleosides by equilibrative nucleoside transporters defines the magnitude of autophagy response and Zika virus replication. Shi SL, Fukuda H, Chujo T, Kouwaki T, Oshiumi H, Tomizawa K, Wei FY. RNA Biol. 2021 Oct 15;18(sup1):478-495. doi: 10.1080/15476286.2021.1960689. Epub 2021 Aug 12. PubMed |
| Discovery of ciliary G protein-coupled receptors regulating pancreatic islet insulin and glucagon secretion. Wu CT, Hilgendorf KI, Bevacqua RJ, Hang Y, Demeter J, Kim SK, Jackson PK. Genes Dev. 2021 Sep 1;35(17-18):1243-1255. doi: 10.1101/gad.348261.121. Epub 2021 Aug 12. PubMed |
| Lrig1 expression identifies airway basal cells with high proliferative capacity and restricts lung squamous cell carcinoma growth. Succony L, Gomez-Lopez S, Pennycuick A, Alhendi ASN, Davies D, Clarke SE, Gowers KHC, Wright NA, Jensen KB, Janes SM. Eur Respir J. 2022 Mar 31;59(3). pii: 13993003.00816-2020. doi: 10.1183/13993003.00816-2020. Print 2022 Mar. PubMed |
| Spontaneous hydrolysis and spurious metabolic properties of alpha-ketoglutarate esters. Parker SJ, Encarnacion-Rosado J, Hollinshead KER, Hollinshead DM, Ash LJ, Rossi JAK, Lin EY, Sohn ASW, Philips MR, Jones DR, Kimmelman AC. Nat Commun. 2021 Aug 12;12(1):4905. doi: 10.1038/s41467-021-25228-9. PubMed |
| Enhanced intratumoural activity of CAR T cells engineered to produce immunomodulators under photothermal control. Miller IC, Zamat A, Sun LK, Phuengkham H, Harris AM, Gamboa L, Yang J, Murad JP, Priceman SJ, Kwong GA. Nat Biomed Eng. 2021 Nov;5(11):1348-1359. doi: 10.1038/s41551-021-00781-2. Epub 2021 Aug 12. PubMed |
| Restoration of the ATG5-dependent autophagy sensitizes DU145 prostate cancer cells to chemotherapeutic drugs. Peng K, Sun A, Zhu J, Gao J, Li Y, Shao G, Yang W, Lin Q. Oncol Lett. 2021 Sep;22(3):638. doi: 10.3892/ol.2021.12899. Epub 2021 Jul 6. PubMed |
| Telomerase therapy reverses vascular senescence and extends lifespan in progeria mice. Mojiri A, Walther BK, Jiang C, Matrone G, Holgate R, Xu Q, Morales E, Wang G, Gu J, Wang R, Cooke JP. Eur Heart J. 2021 Nov 7;42(42):4352-4369. doi: 10.1093/eurheartj/ehab547. PubMed |
| BRD9 is a druggable component of interferon-stimulated gene expression and antiviral activity. Borold J, Eletto D, Busnadiego I, Mair NK, Moritz E, Schiefer S, Schmidt N, Petric PP, Wong WW, Schwemmle M, Hale BG. EMBO Rep. 2021 Oct 5;22(10):e52823. doi: 10.15252/embr.202152823. Epub 2021 Aug 16. PubMed |
| NF1 regulates mesenchymal glioblastoma plasticity and aggressiveness through the AP-1 transcription factor FOSL1. Marques C, Unterkircher T, Kroon P, Oldrini B, Izzo A, Dramaretska Y, Ferrarese R, Kling E, Schnell O, Nelander S, Wagner EF, Bakiri L, Gargiulo G, Carro MS, Squatrito M. Elife. 2021 Aug 17;10. pii: 64846. doi: 10.7554/eLife.64846. PubMed |
| Arhgef2 regulates mitotic spindle orientation in hematopoietic stem cells and is essential for productive hematopoiesis. Chan DCH, Xu J, Vujovic A, Wong N, Gordon V, de Rooij LPMH, Moreira S, Joyce CE, La Rose J, Sandi MJ, Doble BW, Novina CD, Rottapel RK, Hope KJ. Blood Adv. 2021 Aug 24;5(16):3120-3133. doi: 10.1182/bloodadvances.2020002539. PubMed |
| TRAF6 Promoted Tumor Glycolysis in Non-Small-Cell Lung Cancer by Activating the Akt-HIFalpha Pathway. Feng L, Feng S, Nie Z, Deng Y, Xuan Y, Chen X, Lu Y, Liang L, Chen Y. Biomed Res Int. 2021 Aug 6;2021:3431245. doi: 10.1155/2021/3431245. eCollection 2021. PubMed |
| Aging-Associated Differences in Epitranscriptomic m6A Regulation in Response to Acute Cardiac Ischemia/Reperfusion Injury in Female Mice. Su X, Shen Y, Jin Y, Kim IM, Weintraub NL, Tang Y. Front Pharmacol. 2021 Aug 3;12:654316. doi: 10.3389/fphar.2021.654316. eCollection 2021. PubMed |
| MiR-205-driven downregulation of cholesterol biosynthesis through SQLE-inhibition identifies therapeutic vulnerability in aggressive prostate cancer. Kalogirou C, Linxweiler J, Schmucker P, Snaebjornsson MT, Schmitz W, Wach S, Krebs M, Hartmann E, Puhr M, Muller A, Spahn M, Seitz AK, Frank T, Marouf H, Buchel G, Eckstein M, Kubler H, Eilers M, Saar M, Junker K, Rohrig F, Kneitz B, Rosenfeldt MT, Schulze A. Nat Commun. 2021 Aug 20;12(1):5066. doi: 10.1038/s41467-021-25325-9. PubMed |
| TDO2 Was Downregulated in Hepatocellular Carcinoma and Inhibited Cell Proliferation by Upregulating the Expression of p21 and p27. Yu C, Rao D, Zhu H, Liu Q, Huang W, Zhang L, Liang H, Song J, Ding Z. Biomed Res Int. 2021 Aug 13;2021:4708439. doi: 10.1155/2021/4708439. eCollection 2021. PubMed |
| Caspases Switch off the m(6)A RNA Modification Pathway to Foster the Replication of a Ubiquitous Human Tumor Virus. Zhang K, Zhang Y, Maharjan Y, Sugiokto FG, Wan J, Li R. mBio. 2021 Aug 31;12(4):e0170621. doi: 10.1128/mBio.01706-21. Epub 2021 Aug 24. PubMed |
| Genome-wide CRISPR activation screen identifies candidate receptors for SARS-CoV-2 entry. Zhu S, Liu Y, Zhou Z, Zhang Z, Xiao X, Liu Z, Chen A, Dong X, Tian F, Chen S, Xu Y, Wang C, Li Q, Niu X, Pan Q, Du S, Xiao J, Wang J, Wei W. Sci China Life Sci. 2022 Apr;65(4):701-717. doi: 10.1007/s11427-021-1990-5. Epub 2021 Aug 20. PubMed |
| RUSC2 and WDR47 oppositely regulate kinesin-1-dependent distribution of ATG9A to the cell periphery. Guardia CM, Jain A, Mattera R, Friefeld A, Li Y, Bonifacino JS. Mol Biol Cell. 2021 Nov 1;32(21):ar25. doi: 10.1091/mbc.E21-06-0295. Epub 2021 Aug 25. PubMed |
| Downregulation of Hotair or LSD1 Impaired Heart Regeneration in the Neonatal Mouse. Fei Q, Qiu M, Fan G, Zhang B, Wang Q, Zhang S, Wang S, Yang B, Zhang L. DNA Cell Biol. 2021 Sep;40(9):1177-1184. doi: 10.1089/dna.2021.0095. Epub 2021 Aug 24. PubMed |
| Gain-of-function p53(R172H) mutation drives accumulation of neutrophils in pancreatic tumors, promoting resistance to immunotherapy. Siolas D, Vucic E, Kurz E, Hajdu C, Bar-Sagi D. Cell Rep. 2021 Aug 24;36(8):109578. doi: 10.1016/j.celrep.2021.109578. PubMed |
NKD2 mediates stimulation-dependent ORAI1 trafficking to augment Ca(2+) entry in T cells.
Wu B, Woo JS, Vila P, Jew M, Leung J, Sun Z, Srikanth S, Gwack Y.
Cell Rep. 2021 Aug 24;36(8):109603. doi: 10.1016/j.celrep.2021.109603.
PubMed
Associated Plasmids |
| Functional genomics atlas of synovial fibroblasts defining rheumatoid arthritis heritability. Ge X, Frank-Bertoncelj M, Klein K, McGovern A, Kuret T, Houtman M, Burja B, Micheroli R, Shi C, Marks M, Filer A, Buckley CD, Orozco G, Distler O, Morris AP, Martin P, Eyre S, Ospelt C. Genome Biol. 2021 Aug 25;22(1):247. doi: 10.1186/s13059-021-02460-6. PubMed |
| Quantification of microRNA editing using two-tailed RT-qPCR for improved biomarker discovery. Voss G, Edsjo A, Bjartell A, Ceder Y. RNA. 2021 Nov;27(11):1412-1424. doi: 10.1261/rna.078867.121. Epub 2021 Aug 25. PubMed |
| NDST3 deacetylates alpha-tubulin and suppresses V-ATPase assembly and lysosomal acidification. Tang Q, Liu M, Liu Y, Hwang RD, Zhang T, Wang J. EMBO J. 2021 Oct 1;40(19):e107204. doi: 10.15252/embj.2020107204. Epub 2021 Aug 25. PubMed |
| Phosphatidylserine binding directly regulates TIM-3 function. Smith CM, Li A, Krishnamurthy N, Lemmon MA. Biochem J. 2021 Sep 17;478(17):3331-3349. doi: 10.1042/BCJ20210425. PubMed |
| Disruption of RING and PHD Domains of TRIM28 Evokes Differentiation in Human iPSCs. Mazurek S, Oleksiewicz U, Czerwinska P, Wroblewska J, Klimczak M, Wiznerowicz M. Cells. 2021 Jul 29;10(8). pii: cells10081933. doi: 10.3390/cells10081933. PubMed |
Application of prime editing to the correction of mutations and phenotypes in adult mice with liver and eye diseases.
Jang H, Jo DH, Cho CS, Shin JH, Seo JH, Yu G, Gopalappa R, Kim D, Cho SR, Kim JH, Kim HH.
Nat Biomed Eng. 2021 Aug 26. pii: 10.1038/s41551-021-00788-9. doi: 10.1038/s41551-021-00788-9.
PubMed
Associated Plasmids |
Direct observation of aggregate-triggered selective autophagy in human cells.
Janssen AFJ, Korsten G, Nijenhuis W, Katrukha EA, Kapitein LC.
J Cell Sci. 2021 Oct 1;134(19). pii: 271972. doi: 10.1242/jcs.258824. Epub 2021 Oct 6.
PubMed
Associated Plasmids |
| Nanog, in Cooperation with AP1, Increases the Expression of E6/E7 Oncogenes from HPV Types 16/18. Diaz-Tejeda Y, Guido-Jimenez MC, Lopez-Carbajal H, Amador-Molina A, Mendez-Martinez R, Gariglio-Vidal P, Lizano M, Garcia-Carranca A. Viruses. 2021 Jul 28;13(8). pii: v13081482. doi: 10.3390/v13081482. PubMed |
| A Genome-Wide CRISPR/Cas9 Screen Reveals the Requirement of Host Sphingomyelin Synthase 1 for Infection with Pseudorabies Virus Mutant gD(-)Pass. Holper JE, Grey F, Baillie JK, Regan T, Parkinson NJ, Hoper D, Thamamongood T, Schwemmle M, Pannhorst K, Wendt L, Mettenleiter TC, Klupp BG. Viruses. 2021 Aug 9;13(8). pii: v13081574. doi: 10.3390/v13081574. PubMed |
| A Novel Frameshifting Inhibitor Having Antiviral Activity against Zoonotic Coronaviruses. Ahn DG, Yoon GY, Lee S, Ku KB, Kim C, Kim KD, Kwon YC, Kim GW, Kim BT, Kim SJ. Viruses. 2021 Aug 18;13(8). pii: v13081639. doi: 10.3390/v13081639. PubMed |
| Uncovering cancer vulnerabilities by machine learning prediction of synthetic lethality. Benfatto S, Sercin O, Dejure FR, Abdollahi A, Zenke FT, Mardin BR. Mol Cancer. 2021 Aug 28;20(1):111. doi: 10.1186/s12943-021-01405-8. PubMed |
| miR-200c-141 Enhances Sheep Kidney Cell Reprogramming into Pluripotent Cells by Targeting ZEB1. Zhang Y, He Y, Wu P, Hu S, Zhang Y, Chen C. Int J Stem Cells. 2021 Nov 30;14(4):423-433. doi: 10.15283/ijsc21080. PubMed |
| Angiopoietin-like 3 inhibition of endothelial lipase is not modulated by angiopoietin-like 8. Sylvers-Davie KL, Segura-Roman A, Salvi AM, Schache KJ, Davies BSJ. J Lipid Res. 2021;62:100112. doi: 10.1016/j.jlr.2021.100112. Epub 2021 Aug 27. PubMed |
| Targeting the Atf7ip-Setdb1 Complex Augments Antitumor Immunity by Boosting Tumor Immunogenicity. Hu H, Khodadadi-Jamayran A, Dolgalev I, Cho H, Badri S, Chiriboga LA, Zeck B, Lopez De Rodas Gregorio M, Dowling CM, Labbe K, Deng J, Chen T, Zhang H, Zappile P, Chen Z, Ueberheide B, Karatza A, Han H, Ranieri M, Tang S, Jour G, Osman I, Sucker A, Schadendorf D, Tsirigos A, Schalper KA, Velcheti V, Huang HY, Jin Y, Ji H, Poirier JT, Li F, Wong KK. Cancer Immunol Res. 2021 Nov;9(11):1298-1315. doi: 10.1158/2326-6066.CIR-21-0543. Epub 2021 Aug 30. PubMed |
| The Smac mimetic BV6 cooperates with STING to induce necroptosis in apoptosis-resistant pancreatic carcinoma cells. Hannes S, Karlowitz R, van Wijk SJL. Cell Death Dis. 2021 Aug 30;12(9):816. doi: 10.1038/s41419-021-04014-x. PubMed |
| Hypoxia-inducible factor 1-alpha enhances the secretome to rejuvenate adult cardiosphere-derived cells. Saha P, Kim M, Tulshyan A, Guo Y, Mishra R, Li D, Civin CI, Kaushal S, Sharma S. J Thorac Cardiovasc Surg. 2021 Jul 17. pii: S0022-5223(21)01046-1. doi: 10.1016/j.jtcvs.2021.07.015. PubMed |
| Antibody-Drug Conjugate Efficacy in Neuroblastoma: Role of Payload, Resistance Mechanisms, Target Density, and Antibody Internalization. Buongervino S, Lane MV, Garrigan E, Zhelev DV, Dimitrov DS, Bosse KR. Mol Cancer Ther. 2021 Nov;20(11):2228-2239. doi: 10.1158/1535-7163.MCT-20-1034. Epub 2021 Aug 31. PubMed |
| Acquisition of aneuploidy drives mutant p53-associated gain-of-function phenotypes. Redman-Rivera LN, Shaver TM, Jin H, Marshall CB, Schafer JM, Sheng Q, Hongo RA, Beckermann KE, Wheeler FC, Lehmann BD, Pietenpol JA. Nat Commun. 2021 Aug 31;12(1):5184. doi: 10.1038/s41467-021-25359-z. PubMed |
| Targeted T cell receptor gene editing provides predictable T cell product function for immunotherapy. Muller TR, Jarosch S, Hammel M, Leube J, Grassmann S, Bernard B, Effenberger M, Andra I, Chaudhry MZ, Kauferle T, Malo A, Cicin-Sain L, Steinberger P, Feuchtinger T, Protzer U, Schumann K, Neuenhahn M, Schober K, Busch DH. Cell Rep Med. 2021 Aug 17;2(8):100374. doi: 10.1016/j.xcrm.2021.100374. eCollection 2021 Aug 17. PubMed |
| Targeted disruption of GAK stagnates autophagic flux by disturbing lysosomal dynamics. Miyazaki M, Hiramoto M, Takano N, Kokuba H, Takemura J, Tokuhisa M, Hino H, Kazama H, Miyazawa K. Int J Mol Med. 2021 Oct;48(4). pii: 195. doi: 10.3892/ijmm.2021.5028. Epub 2021 Sep 1. PubMed |
| A NSD3-targeted PROTAC suppresses NSD3 and cMyc oncogenic nodes in cancer cells. Xu C, Meng F, Park KS, Storey AJ, Gong W, Tsai YH, Gibson E, Byrum SD, Li D, Edmondson RD, Mackintosh SG, Vedadi M, Cai L, Tackett AJ, Kaniskan HU, Jin J, Wang GG. Cell Chem Biol. 2022 Mar 17;29(3):386-397.e9. doi: 10.1016/j.chembiol.2021.08.004. Epub 2021 Aug 31. PubMed |
| Iron loading induces cholesterol synthesis and sensitizes endothelial cells to TNFalpha-mediated apoptosis. Fisher AL, Srole DN, Palaskas NJ, Meriwether D, Reddy ST, Ganz T, Nemeth E. J Biol Chem. 2021 Oct;297(4):101156. doi: 10.1016/j.jbc.2021.101156. Epub 2021 Sep 2. PubMed |
| Targeting the IRE1alpha/XBP1s pathway suppresses CARM1-expressing ovarian cancer. Lin J, Liu H, Fukumoto T, Zundell J, Yan Q, Tang CA, Wu S, Zhou W, Guo D, Karakashev S, Hu CA, Sarma K, Kossenkov AV, Zhang R. Nat Commun. 2021 Sep 7;12(1):5321. doi: 10.1038/s41467-021-25684-3. PubMed |
| Photoreceptor nanotubes mediate the in vivo exchange of intracellular material. Ortin-Martinez A, Yan NE, Tsai ELS, Comanita L, Gurdita A, Tachibana N, Liu ZC, Lu S, Dolati P, Pokrajac NT, El-Sehemy A, Nickerson PEB, Schuurmans C, Bremner R, Wallace VA. EMBO J. 2021 Nov 15;40(22):e107264. doi: 10.15252/embj.2020107264. Epub 2021 Sep 8. PubMed |
| Cytosolic delivery of CDK4/6 inhibitor p16 protein using engineered protein crystals for cancer therapy. Yang Z, Yang M, Chow HM, Tsang SY, Lee MM, Chan MK. Acta Biomater. 2021 Nov;135:582-592. doi: 10.1016/j.actbio.2021.08.054. Epub 2021 Sep 5. PubMed |
| ZFP36L2 Role in Thyroid Functionality. Albano F, Tucci V, Blackshear PJ, Reale C, Roberto L, Russo F, Marotta P, Porreca I, Colella M, Mallardo M, de Felice M, Ambrosino C. Int J Mol Sci. 2021 Aug 29;22(17). pii: ijms22179379. doi: 10.3390/ijms22179379. PubMed |
| SHP2 as a Potential Therapeutic Target in Diffuse-Type Gastric Carcinoma Addicted to Receptor Tyrosine Kinase Signaling. Nagamura Y, Miyazaki M, Nagano Y, Tomiyama A, Ohki R, Yanagihara K, Sakai R, Yamaguchi H. Cancers (Basel). 2021 Aug 26;13(17). pii: cancers13174309. doi: 10.3390/cancers13174309. PubMed |
| Downregulation of KLF4 activates embryonic and fetal globin mRNA expression in human erythroid progenitor cells. Khamphikham P, Jearawiriyapaisarn N, Tangprasittipap A, Hongeng S. Exp Ther Med. 2021 Oct;22(4):1105. doi: 10.3892/etm.2021.10539. Epub 2021 Aug 2. PubMed |
| Regulation and role of glycophagy in skeletal muscle energy metabolism. Heden TD, Chow LS, Hughey CC, Mashek DG. Autophagy. 2021 Sep 10:1-12. doi: 10.1080/15548627.2021.1969633. PubMed |
| Viral Manipulation of a Mechanoresponsive Signaling Axis Disassembles Processing Bodies. Castle EL, Robinson CA, Douglas P, Rinker KD, Corcoran JA. Mol Cell Biol. 2021 Oct 26;41(11):e0039921. doi: 10.1128/MCB.00399-21. Epub 2021 Sep 13. PubMed |
| Host phospholipid peroxidation fuels ExoU-dependent cell necrosis and supports Pseudomonas aeruginosa-driven pathology. Bagayoko S, Leon-Icaza SA, Pinilla M, Hessel A, Santoni K, Pericat D, Bordignon PJ, Moreau F, Eren E, Boyance A, Naser E, Lefevre L, Berrone C, Iakobachvili N, Metais A, Rombouts Y, Lugo-Villarino G, Coste A, Attree I, Frank DW, Clevers H, Peters PJ, Cougoule C, Planes R, Meunier E. PLoS Pathog. 2021 Sep 13;17(9):e1009927. doi: 10.1371/journal.ppat.1009927. eCollection 2021 Sep. PubMed |
| Mutagenicity Profile Induced by UVB Light in Human Xeroderma Pigmentosum Group C Cells(dagger). Quintero-Ruiz N, Corradi C, Moreno NC, de Souza TA, Pereira Castro L, Rocha CRR, Menck CFM. Photochem Photobiol. 2021 Sep 13. doi: 10.1111/php.13516. PubMed |
| Virus-induced senescence is a driver and therapeutic target in COVID-19. Lee S, Yu Y, Trimpert J, Benthani F, Mairhofer M, Richter-Pechanska P, Wyler E, Belenki D, Kaltenbrunner S, Pammer M, Kausche L, Firsching TC, Dietert K, Schotsaert M, Martinez-Romero C, Singh G, Kunz S, Niemeyer D, Ghanem R, Salzer HJF, Paar C, Mulleder M, Uccellini M, Michaelis EG, Khan A, Lau A, Schonlein M, Habringer A, Tomasits J, Adler JM, Kimeswenger S, Gruber AD, Hoetzenecker W, Steinkellner H, Purfurst B, Motz R, Di Pierro F, Lamprecht B, Osterrieder N, Landthaler M, Drosten C, Garcia-Sastre A, Langer R, Ralser M, Eils R, Reimann M, Fan DNY, Schmitt CA. Nature. 2021 Nov;599(7884):283-289. doi: 10.1038/s41586-021-03995-1. Epub 2021 Sep 13. PubMed |
| MEF2D-NR4A1-FAM134B2-mediated reticulophagy contributes to amino acid homeostasis. Shiozaki Y, Miyazaki-Anzai S, Keenan AL, Miyazaki M. Autophagy. 2021 Sep 14:1-13. doi: 10.1080/15548627.2021.1968228. PubMed |
| Therapeutic inhibition of USP9x-mediated Notch signaling in triple-negative breast cancer. Jaiswal A, Murakami K, Elia A, Shibahara Y, Done SJ, Wood SA, Donato NJ, Ohashi PS, Reedijk M. Proc Natl Acad Sci U S A. 2021 Sep 21;118(38). pii: 2101592118. doi: 10.1073/pnas.2101592118. PubMed |
Intrinsically disordered protein biosensor tracks the physical-chemical effects of osmotic stress on cells.
Cuevas-Velazquez CL, Vellosillo T, Guadalupe K, Schmidt HB, Yu F, Moses D, Brophy JAN, Cosio-Acosta D, Das A, Wang L, Jones AM, Covarrubias AA, Sukenik S, Dinneny JR.
Nat Commun. 2021 Sep 14;12(1):5438. doi: 10.1038/s41467-021-25736-8.
PubMed
Associated Plasmids |
| An active tethering mechanism controls the fate of vesicles. An SJ, Rivera-Molina F, Anneken A, Xi Z, McNellis B, Polejaev VI, Toomre D. Nat Commun. 2021 Sep 14;12(1):5434. doi: 10.1038/s41467-021-25465-y. PubMed |
| Therapeutic targeting of the PLK1-PRC1-axis triggers cell death in genomically silent childhood cancer. Li J, Ohmura S, Marchetto A, Orth MF, Imle R, Dallmayer M, Musa J, Knott MML, Holting TLB, Stein S, Funk CM, Sastre A, Alonso J, Bestvater F, Kasan M, Romero-Perez L, Hartmann W, Ranft A, Banito A, Dirksen U, Kirchner T, Cidre-Aranaz F, Grunewald TGP. Nat Commun. 2021 Sep 16;12(1):5356. doi: 10.1038/s41467-021-25553-z. PubMed |
| Generation of stable cell lines using readthrough expression from lentiviral integration. Jadav A, Truong K. Biotechnol Lett. 2021 Nov;43(11):2131-2136. doi: 10.1007/s10529-021-03186-y. Epub 2021 Sep 17. PubMed |
| Critical Evaluation of Different Lysosomal Labeling Methods Used to Analyze RNA Nanocarrier Trafficking in Cells. Iqbal S, Luo B, Melamed JR, Day ES. Bioconjug Chem. 2021 Oct 20;32(10):2245-2256. doi: 10.1021/acs.bioconjchem.1c00405. Epub 2021 Sep 20. PubMed |
| PCV2 targets cGAS to inhibit type I interferon induction to promote other DNA virus infection. Wang Z, Chen J, Wu X, Ma D, Zhang X, Li R, Han C, Liu H, Yin X, Du Q, Tong D, Huang Y. PLoS Pathog. 2021 Sep 20;17(9):e1009940. doi: 10.1371/journal.ppat.1009940. eCollection 2021 Sep. PubMed |
| ATF4-mediated transcriptional regulation protects against beta-cell loss during endoplasmic reticulum stress in a mouse model. Kitakaze K, Oyadomari M, Zhang J, Hamada Y, Takenouchi Y, Tsuboi K, Inagaki M, Tachikawa M, Fujitani Y, Okamoto Y, Oyadomari S. Mol Metab. 2021 Dec;54:101338. doi: 10.1016/j.molmet.2021.101338. Epub 2021 Sep 20. PubMed |
| Epicardial differentiation drives fibro-fatty remodeling in arrhythmogenic cardiomyopathy. Kohela A, van Kampen SJ, Moens T, Wehrens M, Molenaar B, Boogerd CJ, Monshouwer-Kloots J, Perini I, Goumans MJ, Smits AM, van Tintelen JP, van Rooij E. Sci Transl Med. 2021 Sep 22;13(612):eabf2750. doi: 10.1126/scitranslmed.abf2750. Epub 2021 Sep 22. PubMed |
| Liquid condensation of reprogramming factor KLF4 with DNA provides a mechanism for chromatin organization. Sharma R, Choi KJ, Quan MD, Sharma S, Sankaran B, Park H, LaGrone A, Kim JJ, MacKenzie KR, Ferreon ACM, Kim C, Ferreon JC. Nat Commun. 2021 Sep 22;12(1):5579. doi: 10.1038/s41467-021-25761-7. PubMed |
| Interaction between CD36 and FABP4 modulates adipocyte-induced fatty acid import and metabolism in breast cancer. Gyamfi J, Yeo JH, Kwon D, Min BS, Cha YJ, Koo JS, Jeong J, Lee J, Choi J. NPJ Breast Cancer. 2021 Sep 24;7(1):129. doi: 10.1038/s41523-021-00324-7. PubMed |
| The identification of a shorter cyclic GMP-AMP synthase gene from chickens and bioinformatics analysis of its potential signaling in IFN regulation. Zhu W, Cheng Y, Wang Z, Ji L, Ma J, Yan Y, Wang H, Sun J. Dev Comp Immunol. 2022 Feb;127:104266. doi: 10.1016/j.dci.2021.104266. Epub 2021 Sep 23. PubMed |
| A Co-Culture-Based Multiparametric Imaging Technique to Dissect Local H2O2 Signals with Targeted HyPer7. Secilmis M, Altun HY, Pilic J, Erdogan YC, Cokluk Z, Ata BN, Sevimli G, Zaki AG, Yigit EN, Ozturk G, Malli R, Eroglu E. Biosensors (Basel). 2021 Sep 14;11(9). pii: bios11090338. doi: 10.3390/bios11090338. PubMed |
| Perturbation-Based Modeling Unveils the Autophagic Modulation of Chemosensitivity and Immunogenicity in Breast Cancer Cells. Quiros-Fernandez I, Figueroa-Protti L, Arias-Arias JL, Brenes-Cordero N, Siles F, Mora J, Mora-Rodriguez RA. Metabolites. 2021 Sep 18;11(9). pii: metabo11090637. doi: 10.3390/metabo11090637. PubMed |
The Role of Pancreatic Alpha Cells and Endothelial Cells in the Reduction of Oxidative Stress in Pseudoislets.
Wieland FC, Sthijns MMJPE, Geuens T, van Blitterswijk CA, LaPointe VLS.
Front Bioeng Biotechnol. 2021 Sep 9;9:729057. doi: 10.3389/fbioe.2021.729057. eCollection 2021.
PubMed
Associated Plasmids |
| Capturing Salmonella SspH2 Host Targets in Virus-Like Particles. De Meyer M, Fijalkowski I, Jonckheere V, De Sutter D, Eyckerman S, Van Damme P. Front Med (Lausanne). 2021 Sep 8;8:725072. doi: 10.3389/fmed.2021.725072. eCollection 2021. PubMed |
| A persistent invasive phenotype in post-hypoxic tumor cells is revealed by fate mapping and computational modeling. Rocha HL, Godet I, Kurtoglu F, Metzcar J, Konstantinopoulos K, Bhoyar S, Gilkes DM, Macklin P. iScience. 2021 Aug 4;24(9):102935. doi: 10.1016/j.isci.2021.102935. eCollection 2021 Sep 24. PubMed |
| Assessing the Wnt-reactivity of cytonemes of mouse embryonic stem cells using a bioengineering approach. Junyent S, Reeves J, Habib SJ. STAR Protoc. 2021 Sep 15;2(3):100813. doi: 10.1016/j.xpro.2021.100813. eCollection 2021 Sep 17. PubMed |
| Titan Cells and Yeast Forms of Cryptococcus neoformans and Cryptococcus gattii Are Recognized by GXMR-CAR. Dos Santos MH, Machado MP, Kumaresan PR, da Silva TA. Microorganisms. 2021 Sep 5;9(9). pii: microorganisms9091886. doi: 10.3390/microorganisms9091886. PubMed |
| Efficient Inhibition of HIV Using CRISPR/Cas13d Nuclease System. Nguyen H, Wilson H, Jayakumar S, Kulkarni V, Kulkarni S. Viruses. 2021 Sep 16;13(9). pii: v13091850. doi: 10.3390/v13091850. PubMed |
| Methylglyoxal Forms Diverse Mercaptomethylimidazole Crosslinks with Thiol and Guanidine Pairs in Endogenous Metabolites and Proteins. Coukos JS, Moellering RE. ACS Chem Biol. 2021 Nov 19;16(11):2453-2461. doi: 10.1021/acschembio.1c00553. Epub 2021 Sep 28. PubMed |
| Regulatory variants at 2q33.1 confer schizophrenia risk by modulating distal gene TYW5 expression. Li S, Li J, Liu J, Wang J, Li X, Huo Y, Li Y, Liu Y, Li M, Xiao X, Luo XJ. Brain. 2022 Apr 18;145(2):770-786. doi: 10.1093/brain/awab357. PubMed |
| Beta-Pix-dynamin 2 complex promotes colorectal cancer progression by facilitating membrane dynamics. Keum S, Yang SJ, Park E, Kang T, Choi JH, Jeong J, Hwang YE, Kim JW, Park D, Rhee S. Cell Oncol (Dordr). 2021 Dec;44(6):1287-1305. doi: 10.1007/s13402-021-00637-6. Epub 2021 Sep 28. PubMed |
Revisiting astrocyte to neuron conversion with lineage tracing in vivo.
Wang LL, Serrano C, Zhong X, Ma S, Zou Y, Zhang CL.
Cell. 2021 Oct 14;184(21):5465-5481.e16. doi: 10.1016/j.cell.2021.09.005. Epub 2021 Sep 27.
PubMed
Associated Plasmids |
| A guide in lentiviral vector production for hard-to-transfect cells, using cardiac-derived c-kit expressing cells as a model system. Kalidasan V, Ng WH, Ishola OA, Ravichantar N, Tan JJ, Das KT. Sci Rep. 2021 Sep 28;11(1):19265. doi: 10.1038/s41598-021-98657-7. PubMed |
| Intravital imaging technology guides FAK-mediated priming in pancreatic cancer precision medicine according to Merlin status. Murphy KJ, Reed DA, Vennin C, Conway JRW, Nobis M, Yin JX, Chambers CR, Pereira BA, Lee V, Filipe EC, Trpceski M, Ritchie S, Lucas MC, Warren SC, Skhinas JN, Magenau A, Metcalf XL, Stoehr J, Major G, Parkin A, Bidanel R, Lyons RJ, Zaratzian A, Tayao M, Da Silva A, Abdulkhalek L, Gill AJ, Johns AL, Biankin AV, Samra J, Grimmond SM, Chou A, Goetz JG, Samuel MS, Lyons JG, Burgess A, Caldon CE, Horvath LG, Daly RJ, Gadegaard N, Wang Y, Sansom OJ, Morton JP, Cox TR, Pajic M, Herrmann D, Timpson P. Sci Adv. 2021 Oct;7(40):eabh0363. doi: 10.1126/sciadv.abh0363. Epub 2021 Sep 29. PubMed |
| Dendritic Cell-Specific Role for Pellino2 as a Mediator of TLR9 Signaling Pathway. Oleszycka E, Rodgers AM, Xu L, Moynagh PN. J Immunol. 2021 Nov 1;207(9):2325-2336. doi: 10.4049/jimmunol.2100236. Epub 2021 Sep 29. PubMed |
Unraveling the functional role of DNA demethylation at specific promoters by targeted steric blockage of DNA methyltransferase with CRISPR/dCas9.
Sapozhnikov DM, Szyf M.
Nat Commun. 2021 Sep 29;12(1):5711. doi: 10.1038/s41467-021-25991-9.
PubMed
Associated Plasmids |
| Mapping Genetic Interactions in Human Cancer Cells Using a One-Step tRNA-CRISPR System. Zhang DY, Gui X, Yang X. Methods Mol Biol. 2021;2381:175-187. doi: 10.1007/978-1-0716-1740-3_9. PubMed |
| Sphingosine 1-phosphate receptor type 2 positively regulates interleukin (IL)-4/IL-13-induced STAT6 phosphorylation. Okamoto Y, Kitakaze K, Takenouchi Y, Yamamoto S, Ishimaru H, Tsuboi K. Cell Signal. 2021 Dec;88:110156. doi: 10.1016/j.cellsig.2021.110156. Epub 2021 Sep 28. PubMed |
| Development of a DELFIA method to detect oncofetal antigen ROR1-positive exosomes. Daikuzono H, Yamazaki M, Sato Y, Takahashi T, Yamagata K. Biochem Biophys Res Commun. 2021 Nov 12;578:170-176. doi: 10.1016/j.bbrc.2021.08.054. Epub 2021 Aug 24. PubMed |
| A highly potent antibody effective against SARS-CoV-2 variants of concern. Fenwick C, Turelli P, Perez L, Pellaton C, Esteves-Leuenberger L, Farina A, Campos J, Lana E, Fiscalini F, Raclot C, Pojer F, Lau K, Demurtas D, Descatoire M, Joo VS, Foglierini M, Noto A, Abdelnabi R, Foo CS, Vangeel L, Neyts J, Du W, Bosch BJ, Veldman G, Leyssen P, Thiel V, LeGrand R, Levy Y, Trono D, Pantaleo G. Cell Rep. 2021 Oct 12;37(2):109814. doi: 10.1016/j.celrep.2021.109814. Epub 2021 Sep 21. PubMed |
| Overexpression of lncRNAs with endogenous lengths and functions using a lncRNA delivery system based on transposon. Zhang Y, Huang YX, Jin X, Chen J, Peng L, Wang DL, Li Y, Yao XY, Liao JY, He JH, Hu K, Lu D, Guo Y, Yin D. J Nanobiotechnology. 2021 Oct 2;19(1):303. doi: 10.1186/s12951-021-01044-7. PubMed |
| The deubiquitinase USP11 is a versatile and conserved regulator of autophagy. Basic M, Hertel A, Bajdzienko J, Bonn F, Tellechea M, Stolz A, Kern A, Behl C, Bremm A. J Biol Chem. 2021 Nov;297(5):101263. doi: 10.1016/j.jbc.2021.101263. Epub 2021 Sep 30. PubMed |
| Development and Initial Characterization of Cellular Models for COG Complex-Related CDG-II Diseases. Sumya FT, Pokrovskaya ID, Lupashin V. Front Genet. 2021 Sep 17;12:733048. doi: 10.3389/fgene.2021.733048. eCollection 2021. PubMed |
| Myogenin controls via AKAP6 non-centrosomal microtubule-organizing center formation at the nuclear envelope. Becker R, Vergarajauregui S, Billing F, Sharkova M, Lippolis E, Mamchaoui K, Ferrazzi F, Engel FB. Elife. 2021 Oct 4;10. pii: 65672. doi: 10.7554/eLife.65672. PubMed |
| PHDs/CPT1B/VDAC1 axis regulates long-chain fatty acid oxidation in cardiomyocytes. Angelini A, Saha PK, Jain A, Jung SY, Mynatt RL, Pi X, Xie L. Cell Rep. 2021 Oct 5;37(1):109767. doi: 10.1016/j.celrep.2021.109767. PubMed |
| A Simple, Rapid, and Cost-Effective Method for Loss-of-Function Assays in Pluripotent Cells. Covelo-Molares H, Souto Y, Fidalgo M, Guallar D. Methods Mol Biol. 2021 Oct 6. doi: 10.1007/7651_2021_434. PubMed |
A functional genetic toolbox for human tissue-derived organoids.
Sun D, Evans L, Perrone F, Sokleva V, Lim K, Rezakhani S, Lutolf M, Zilbauer M, Rawlins EL.
eLife. 2021 Oct 6;10. pii: 67886. doi: 10.7554/eLife.67886.
PubMed
Associated Plasmids |
AKAP79 enables calcineurin to directly suppress protein kinase A activity.
Church TW, Tewatia P, Hannan S, Antunes J, Eriksson O, Smart TG, Hellgren Kotaleski J, Gold MG.
Elife. 2021 Oct 6;10. pii: 68164. doi: 10.7554/eLife.68164.
PubMed
Associated Plasmids |
| Zika Virus Requires the Expression of Claudin-7 for Optimal Replication in Human Endothelial Cells. Zoladek J, Legros V, Jeannin P, Chazal M, Pardigon N, Ceccaldi PE, Gessain A, Jouvenet N, Afonso PV. Front Microbiol. 2021 Sep 20;12:746589. doi: 10.3389/fmicb.2021.746589. eCollection 2021. PubMed |
| Cochlear Sox2(+) Glial Cells Are Potent Progenitors for Spiral Ganglion Neuron Reprogramming Induced by Small Molecules. Chen Z, Huang Y, Yu C, Liu Q, Qiu C, Wan G. Front Cell Dev Biol. 2021 Sep 21;9:728352. doi: 10.3389/fcell.2021.728352. eCollection 2021. PubMed |
| CCNE1 copy number is a biomarker for response to combination WEE1-ATR inhibition in ovarian and endometrial cancer models. Xu H, George E, Kinose Y, Kim H, Shah JB, Peake JD, Ferman B, Medvedev S, Murtha T, Barger CJ, Devins KM, D'Andrea K, Wubbenhorst B, Schwartz LE, Hwang WT, Mills GB, Nathanson KL, Karpf AR, Drapkin R, Brown EJ, Simpkins F. Cell Rep Med. 2021 Sep 23;2(9):100394. doi: 10.1016/j.xcrm.2021.100394. eCollection 2021 Sep 21. PubMed |
| Detection and differentiation of murine leukemia virus (MLV) and murine stem cell virus (MSCV) and therefrom derived nucleic acids. Volkwein W, Pavlovic M, Anton M, Haase M, Stellberger T, Jarrar A, Busch U, Baiker A. J Virol Methods. 2022 Jan;299:114316. doi: 10.1016/j.jviromet.2021.114316. Epub 2021 Oct 7. PubMed |
| hnRNPA2B1 Promotes Colon Cancer Progression via the MAPK Pathway. Tang J, Chen Z, Wang Q, Hao W, Gao WQ, Xu H. Front Genet. 2021 Sep 22;12:666451. doi: 10.3389/fgene.2021.666451. eCollection 2021. PubMed |
Replacing the SpCas9 HNH domain by deaminases generates compact base editors with an alternative targeting scope.
Villiger L, Schmidheini L, Mathis N, Rothgangl T, Marquart K, Schwank G.
Mol Ther Nucleic Acids. 2021 Aug 26;26:502-510. doi: 10.1016/j.omtn.2021.08.025. eCollection 2021 Dec 3.
PubMed
Associated Plasmids |
| Sulfation of glycosaminoglycans depends on the catalytic activity of lithium-inhibited phosphatase BPNT2 in vitro. Eisele BS, Luka Z, Wu AJ, Yang F, Hale AT, York JD. J Biol Chem. 2021 Nov;297(5):101293. doi: 10.1016/j.jbc.2021.101293. Epub 2021 Oct 8. PubMed |
| IRAK1-dependent Regnase-1-14-3-3 complex formation controls Regnase-1-mediated mRNA decay. Akaki K, Ogata K, Yamauchi Y, Iwai N, Tse KM, Hia F, Mochizuki A, Ishihama Y, Mino T, Takeuchi O. Elife. 2021 Oct 12;10. pii: 71966. doi: 10.7554/eLife.71966. PubMed |
| TEC kinase stabilizes PLK4 to promote liver cancer metastasis. Yeung SF, Zhou Y, Zou W, Chan WL, Ching YP. Cancer Lett. 2022 Jan 1;524:70-81. doi: 10.1016/j.canlet.2021.08.038. Epub 2021 Oct 9. PubMed |
| MAPK15 Controls Hedgehog Signaling in Medulloblastoma Cells by Regulating Primary Ciliogenesis. Pietrobono S, Franci L, Imperatore F, Zanini C, Stecca B, Chiariello M. Cancers (Basel). 2021 Sep 29;13(19). pii: cancers13194903. doi: 10.3390/cancers13194903. PubMed |
| Transcription Factor RBPJL Is Able to Repress Notch Target Gene Expression but Is Non-Responsive to Notch Activation. Pan L, Hoffmeister P, Turkiewicz A, Huynh NND, Grosse-Berkenbusch A, Knippschild U, Gebhardt JCM, Baumann B, Borggrefe T, Oswald F. Cancers (Basel). 2021 Oct 8;13(19). pii: cancers13195027. doi: 10.3390/cancers13195027. PubMed |
| Cooperative methylation of human tRNA3Lys at positions A58 and U54 drives the early and late steps of HIV-1 replication. Fukuda H, Chujo T, Wei FY, Shi SL, Hirayama M, Kaitsuka T, Yamamoto T, Oshiumi H, Tomizawa K. Nucleic Acids Res. 2021 Nov 18;49(20):11855-11867. doi: 10.1093/nar/gkab879. PubMed |
| Specific Activation of the CD271 Intracellular Domain in Combination with Chemotherapy or Targeted Therapy Inhibits Melanoma Progression. Saltari A, Dzung A, Quadri M, Tiso N, Facchinello N, Hernandez-Barranco A, Garcia-Silva S, Nogues L, Stoffel CI, Cheng PF, Turko P, Eichhoff OM, Truzzi F, Marconi A, Pincelli C, Peinado H, Dummer R, Levesque MP. Cancer Res. 2021 Dec 1;81(23):6044-6057. doi: 10.1158/0008-5472.CAN-21-0117. Epub 2021 Oct 13. PubMed |
| Supraphysiologic Testosterone Induces Ferroptosis and Activates Immune Pathways through Nucleophagy in Prostate Cancer. Kumar R, Mendonca J, Owoyemi O, Boyapati K, Thomas N, Kanacharoen S, Coffey M, Topiwala D, Gomes C, Ozbek B, Jones T, Rosen M, Dong L, Wiens S, Brennen WN, Isaacs JT, De Marzo AM, Markowski MC, Antonarakis ES, Qian DZ, Pienta KJ, Pardoll DM, Carducci MA, Denmeade SR, Kachhap SK. Cancer Res. 2021 Dec 1;81(23):5948-5962. doi: 10.1158/0008-5472.CAN-20-3607. Epub 2021 Oct 13. PubMed |
| Site-specific N-glycosylation of integrin alpha2 mediates collagen-dependent cell survival. Huang YL, Liang CY, Labitzky V, Ritz D, Oliveira T, Cumin C, Estermann M, Lange T, Everest-Dass AV, Jacob F. iScience. 2021 Sep 25;24(10):103168. doi: 10.1016/j.isci.2021.103168. eCollection 2021 Oct 22. PubMed |
Plexin-B2 orchestrates collective stem cell dynamics via actomyosin contractility, cytoskeletal tension and adhesion.
Junqueira Alves C, Dariolli R, Haydak J, Kang S, Hannah T, Wiener RJ, DeFronzo S, Tejero R, Gusella GL, Ramakrishnan A, Alves Dias R, Wojcinski A, Kesari S, Shen L, Sobie EA, Rodrigues Furtado de Mendonca JP, Azeloglu EU, Zou H, Friedel RH.
Nat Commun. 2021 Oct 14;12(1):6019. doi: 10.1038/s41467-021-26296-7.
PubMed
Associated Plasmids |
| Human Erbb2-induced Erk activity robustly stimulates cycling and functional remodeling of rat and human cardiomyocytes. Strash N, DeLuca S, Janer Carattini GL, Heo SC, Gorsuch R, Bursac N. Elife. 2021 Oct 19;10. pii: 65512. doi: 10.7554/eLife.65512. PubMed |
| Translational repression of NMD targets by GIGYF2 and EIF4E2. Zinshteyn B, Sinha NK, Enam SU, Koleske B, Green R. PLoS Genet. 2021 Oct 19;17(10):e1009813. doi: 10.1371/journal.pgen.1009813. eCollection 2021 Oct. PubMed |
| Benzyl-para-di-[5-methyl-4-(n-octylamino) pyrimidin-2(1H)one] as an interferon beta (IFN-beta) modulator. Trifonov L, Yurchenko M, Skjesol A, Cohen G, Espevik T, Korshin EE, Grovdal LM, Husebye H, Gruzman A. Mol Divers. 2021 Oct 19. pii: 10.1007/s11030-021-10324-1. doi: 10.1007/s11030-021-10324-1. PubMed |
| Retinoic acid rewires the adrenergic core regulatory circuitry of childhood neuroblastoma. Zimmerman MW, Durbin AD, He S, Oppel F, Shi H, Tao T, Li Z, Berezovskaya A, Liu Y, Zhang J, Young RA, Abraham BJ, Look AT. Sci Adv. 2021 Oct 22;7(43):eabe0834. doi: 10.1126/sciadv.abe0834. Epub 2021 Oct 20. PubMed |
| Development of a selective fluorescence-based enzyme assay for glycerophosphodiesterase family members GDE4 and GDE7. Kitakaze K, Tsuboi K, Tsuda M, Takenouchi Y, Ishimaru H, Okamoto Y. J Lipid Res. 2021;62:100141. doi: 10.1016/j.jlr.2021.100141. Epub 2021 Oct 18. PubMed |
| Steroid sulfatase deficiency causes cellular senescence and abnormal differentiation by inducing Yippee-like 3 expression in human keratinocytes. Baek HS, Kwon TU, Shin S, Kwon YJ, Chun YJ. Sci Rep. 2021 Oct 21;11(1):20867. doi: 10.1038/s41598-021-00051-w. PubMed |
| Traf2 and NCK Interacting Kinase Is a Critical Regulator of Procollagen I Trafficking and Hepatic Fibrogenesis in Mice. Buchl SC, Hanquier Z, Haak AJ, Thomason YM, Huebert RC, Shah VH, Maiers JL. Hepatol Commun. 2022 Mar;6(3):593-609. doi: 10.1002/hep4.1835. Epub 2021 Oct 22. PubMed |
| CRISPR activation of endogenous genes reprograms fibroblasts into cardiovascular progenitor cells for myocardial infarction therapy. Jiang L, Liang J, Huang W, Ma J, Park KH, Wu Z, Chen P, Zhu H, Ma JJ, Cai W, Paul C, Niu L, Fan GC, Wang HS, Kanisicak O, Xu M, Wang Y. Mol Ther. 2022 Jan 5;30(1):54-74. doi: 10.1016/j.ymthe.2021.10.015. Epub 2021 Oct 20. PubMed |
| Deficiency of the Lysosomal Protein CLN5 Alters Lysosomal Function and Movement. Basak I, Hansen RA, Ward ME, Hughes SM. Biomolecules. 2021 Sep 27;11(10). pii: biom11101412. doi: 10.3390/biom11101412. PubMed |
| Effective chimeric antigen receptor T cells against SARS-CoV-2. Guo X, Kazanova A, Thurmond S, Saragovi HU, Rudd CE. iScience. 2021 Nov 19;24(11):103295. doi: 10.1016/j.isci.2021.103295. Epub 2021 Oct 16. PubMed |
| FCRL1 Regulates B Cell Receptor-Induced ERK Activation through GRB2. DeLuca JM, Murphy MK, Wang X, Wilson TJ. J Immunol. 2021 Dec 1;207(11):2688-2698. doi: 10.4049/jimmunol.2100218. Epub 2021 Oct 25. PubMed |
| Resistance of SARS-CoV-2 variants to neutralization by convalescent plasma from early COVID-19 outbreak in Singapore. Wang B, Goh YS, Prince T, Ngoh EZX, Salleh SNM, Hor PX, Loh CY, Fong SW, Hartley C, Tan SY, Young BE, Leo YS, Lye DC, Maurer-Stroh S, Ng LFP, Hiscox JA, Renia L, Wang CI. NPJ Vaccines. 2021 Oct 25;6(1):125. doi: 10.1038/s41541-021-00389-2. PubMed |
| Single-stranded DNA binding proteins influence APOBEC3A substrate preference. Brown AL, Collins CD, Thompson S, Coxon M, Mertz TM, Roberts SA. Sci Rep. 2021 Oct 25;11(1):21008. doi: 10.1038/s41598-021-00435-y. PubMed |
| PIM1 phosphorylation of the androgen receptor and 14-3-3 zeta regulates gene transcription in prostate cancer. Ruff SE, Vasilyev N, Nudler E, Logan SK, Garabedian MJ. Commun Biol. 2021 Oct 25;4(1):1221. doi: 10.1038/s42003-021-02723-9. PubMed |
| GAS1 is required for NOTCH-dependent facilitation of SHH signaling in the ventral forebrain neuroepithelium. Marczenke M, Sunaga-Franze DY, Popp O, Althaus IW, Sauer S, Mertins P, Christ A, Allen BL, Willnow TE. Development. 2021 Nov 1;148(21). pii: 272617. doi: 10.1242/dev.200080. Epub 2021 Nov 11. PubMed |
| Dnmt3a-mutated clonal hematopoiesis promotes osteoporosis. Kim PG, Niroula A, Shkolnik V, McConkey M, Lin AE, Slabicki M, Kemp JP, Bick A, Gibson CJ, Griffin G, Sekar A, Brooks DJ, Wong WJ, Cohen DN, Uddin MM, Shin WJ, Pirruccello J, Tsai JM, Agrawal M, Kiel DP, Bouxsein ML, Richards JB, Evans DM, Wein MN, Charles JF, Jaiswal S, Natarajan P, Ebert BL. J Exp Med. 2021 Dec 6;218(12). pii: 212724. doi: 10.1084/jem.20211872. Epub 2021 Oct 26. PubMed |
| Non-targeting control for MISSION shRNA library silences SNRPD3 leading to cell death or permanent growth arrest. Czarnek M, Sarad K, Karas A, Kochan J, Bereta J. Mol Ther Nucleic Acids. 2021 Sep 15;26:711-731. doi: 10.1016/j.omtn.2021.09.004. eCollection 2021 Dec 3. PubMed |
| Establishment of a pig CRISPR/Cas9 knockout library for functional gene screening in pig cells. Yu C, Zhong H, Yang X, Li G, Wu Z, Yang H. Biotechnol J. 2021 Oct 27:e2100408. doi: 10.1002/biot.202100408. PubMed |
| Defining the fetal origin of MLL-AF4 infant leukemia highlights specific fatty acid requirements. Symeonidou V, Jakobczyk H, Bashanfer S, Malouf C, Fotopoulou F, Kotecha RS, Anderson RA, Finch AJ, Ottersbach K. Cell Rep. 2021 Oct 26;37(4):109900. doi: 10.1016/j.celrep.2021.109900. PubMed |
| GCN2 adapts protein synthesis to scavenging-dependent growth. Nofal M, Wang T, Yang L, Jankowski CSR, Hsin-Jung Li S, Han S, Parsons L, Frese AN, Gitai Z, Anthony TG, Wuhr M, Sabatini DM, Rabinowitz JD. Cell Syst. 2022 Feb 16;13(2):158-172.e9. doi: 10.1016/j.cels.2021.09.014. Epub 2021 Oct 26. PubMed |
| Target Identification of Small Molecules Using Large-Scale CRISPR-Cas Mutagenesis Scanning of Essential Genes. Kwanten B, Neggers JE, Daelemans D. Methods Mol Biol. 2022;2377:43-67. doi: 10.1007/978-1-0716-1720-5_3. PubMed |
| RNA-responsive elements for eukaryotic translational control. Zhao EM, Mao AS, de Puig H, Zhang K, Tippens ND, Tan X, Ran FA, Han I, Nguyen PQ, Chory EJ, Hua TY, Ramesh P, Thompson DB, Oh CY, Zigon ES, English MA, Collins JJ. Nat Biotechnol. 2022 Apr;40(4):539-545. doi: 10.1038/s41587-021-01068-2. Epub 2021 Oct 28. PubMed |
| MI-773, a breaker of the MDM2/p53 axis, exhibits anticancer effects in neuroblastoma via downregulation of INSM1. Chen YL, Zhang ZM, Li XL, Tao YF, Wu SY, Fang F, Xie Y, Liao XM, Li G, Wu D, Wang HR, Zuo R, Cao HB, Pan JJ, Yu JJ, Zhang Z, Chu XR, Zhang YP, Feng CX, Wang JW, Lu J, Hu SY, Li ZH, Pan J. Oncol Lett. 2021 Dec;22(6):838. doi: 10.3892/ol.2021.13099. Epub 2021 Oct 18. PubMed |
| MiRNA-146a/AKT/beta-Catenin Activation Regulates Cancer Stem Cell Phenotype in Oral Squamous Cell Carcinoma by Targeting CD24. Ghuwalewala S, Ghatak D, Das S, Roy S, Das P, Butti R, Gorain M, Nath S, Kundu GC, Roychoudhury S. Front Oncol. 2021 Oct 12;11:651692. doi: 10.3389/fonc.2021.651692. eCollection 2021. PubMed |
| FACS-based protocol to assess cytotoxicity and clonogenic potential of colorectal cancer stem cells using a Wnt/beta-catenin signaling pathway reporter. Di Franco S, Zhang L, Gaggianesi M, Lo Iacono M, Medema JP, Stassi G. STAR Protoc. 2021 Oct 19;2(4):100880. doi: 10.1016/j.xpro.2021.100880. eCollection 2021 Dec 17. PubMed |
| Genetic, cellular, and structural characterization of the membrane potential-dependent cell-penetrating peptide translocation pore. Trofimenko E, Grasso G, Heulot M, Chevalier N, Deriu MA, Dubuis G, Arribat Y, Serulla M, Michel S, Vantomme G, Ory F, Dam LC, Puyal J, Amati F, Luthi A, Danani A, Widmann C. Elife. 2021 Oct 29;10. pii: 69832. doi: 10.7554/eLife.69832. PubMed |
| CHRAC1 promotes human lung cancer growth through regulating YAP transcriptional activity. Wang M, Li S, Guo W, Wang L, Huang J, Zhuo J, Lai B, Liao C, Ge T, Nie Y, Jin S, Wang M, Zhang Y, Liu Y, Li X, Zhang H. Carcinogenesis. 2022 Apr 25;43(3):264-276. doi: 10.1093/carcin/bgab103. PubMed |
| Control of osteocyte dendrite formation by Sp7 and its target gene osteocrin. Wang JS, Kamath T, Mazur CM, Mirzamohammadi F, Rotter D, Hojo H, Castro CD, Tokavanich N, Patel R, Govea N, Enishi T, Wu Y, da Silva Martins J, Bruce M, Brooks DJ, Bouxsein ML, Tokarz D, Lin CP, Abdul A, Macosko EZ, Fiscaletti M, Munns CF, Ryder P, Kost-Alimova M, Byrne P, Cimini B, Fujiwara M, Kronenberg HM, Wein MN. Nat Commun. 2021 Nov 1;12(1):6271. doi: 10.1038/s41467-021-26571-7. PubMed |
| Anti-apoptotic MCL1 Protein Represents Critical Survival Molecule for Most Burkitt Lymphomas and BCL2-negative Diffuse Large B-cell Lymphomas. Klanova M, Kazantsev D, Pokorna E, Zikmund T, Karolova J, Behounek M, Renesova N, Sovilj D, Kelemen CD, Helman K, Jaksa R, Havranek O, Andera L, Trneny M, Klener P. Mol Cancer Ther. 2022 Jan;21(1):89-99. doi: 10.1158/1535-7163.MCT-21-0511. Epub 2021 Nov 2. PubMed |
| Lentiviral and adeno-associated vectors efficiently transduce mouse T lymphocytes when targeted to murine CD8. Michels A, Frank AM, Gunther DM, Mataei M, Borner K, Grimm D, Hartmann J, Buchholz CJ. Mol Ther Methods Clin Dev. 2021 Oct 1;23:334-347. doi: 10.1016/j.omtm.2021.09.014. eCollection 2021 Dec 10. PubMed |
| Ibrutinib Blocks YAP1 Activation and Reverses BRAF Inhibitor Resistance in Melanoma Cells. Misek SA, Newbury PA, Chekalin E, Paithankar S, Doseff AI, Chen B, Gallo KA, Neubig RR. Mol Pharmacol. 2022 Jan;101(1):1-12. doi: 10.1124/molpharm.121.000331. Epub 2021 Nov 3. PubMed |
| ARV-825 Demonstrates Antitumor Activity in Gastric Cancer via MYC-Targets and G2M-Checkpoint Signaling Pathways. Liao X, Qian X, Zhang Z, Tao Y, Li Z, Zhang Q, Liang H, Li X, Xie Y, Zhuo R, Chen Y, Jiang Y, Cao H, Niu J, Xue C, Ni J, Pan J, Cui D. Front Oncol. 2021 Oct 18;11:753119. doi: 10.3389/fonc.2021.753119. eCollection 2021. PubMed |
| CRISPR-based RNA-binding protein mapping in live cells. Chen B, Shi H, Zhang J, Zhou C, Han M, Jiang W, Lai Y, Tu X, Li H. Biochem Biophys Res Commun. 2021 Oct 29;583:79-85. doi: 10.1016/j.bbrc.2021.10.059. PubMed |
| Chromatin-accessibility estimation from single-cell ATAC-seq data with scOpen. Li Z, Kuppe C, Ziegler S, Cheng M, Kabgani N, Menzel S, Zenke M, Kramann R, Costa IG. Nat Commun. 2021 Nov 4;12(1):6386. doi: 10.1038/s41467-021-26530-2. PubMed |
| Bovine mammary alveolar MAC-T cells afford a tool for studies of bovine milk exosomes in drug delivery. Ogunnaike M, Wang H, Zempleni J. Int J Pharm. 2021 Dec 15;610:121263. doi: 10.1016/j.ijpharm.2021.121263. Epub 2021 Nov 4. PubMed |
| CEBPG promotes acute myeloid leukemia progression by enhancing EIF4EBP1. Jiang Y, Wu SY, Chen YL, Zhang ZM, Tao YF, Xie Y, Liao XM, Li XL, Li G, Wu D, Wang HR, Zuo R, Cao HB, Pan JJ, Yu JJ, Jia SQ, Zhang Z, Chu XR, Zhang YP, Feng CX, Wang JW, Hu SY, Li ZH, Pan J, Fang F, Lu J. Cancer Cell Int. 2021 Nov 7;21(1):598. doi: 10.1186/s12935-021-02305-z. PubMed |
| Mutation Y453F in the spike protein of SARS-CoV-2 enhances interaction with the mink ACE2 receptor for host adaption. Ren W, Lan J, Ju X, Gong M, Long Q, Zhu Z, Yu Y, Wu J, Zhong J, Zhang R, Fan S, Zhong G, Huang A, Wang X, Ding Q. PLoS Pathog. 2021 Nov 8;17(11):e1010053. doi: 10.1371/journal.ppat.1010053. eCollection 2021 Nov. PubMed |
| Time-Resolved Scanning Ion Conductance Microscopy for Three-Dimensional Tracking of Nanoscale Cell Surface Dynamics. Leitao SM, Drake B, Pinjusic K, Pierrat X, Navikas V, Nievergelt AP, Brillard C, Djekic D, Radenovic A, Persat A, Constam DB, Anders J, Fantner GE. ACS Nano. 2021 Nov 9. doi: 10.1021/acsnano.1c05202. PubMed |
| The chemotherapeutic CX-5461 primarily targets TOP2B and exhibits selective activity in high-risk neuroblastoma. Pan M, Wright WC, Chapple RH, Zubair A, Sandhu M, Batchelder JE, Huddle BC, Low J, Blankenship KB, Wang Y, Gordon B, Archer P, Brady SW, Natarajan S, Posgai MJ, Schuetz J, Miller D, Kalathur R, Chen S, Connelly JP, Babu MM, Dyer MA, Pruett-Miller SM, Freeman BB 3rd, Chen T, Godley LA, Blanchard SC, Stewart E, Easton J, Geeleher P. Nat Commun. 2021 Nov 9;12(1):6468. doi: 10.1038/s41467-021-26640-x. PubMed |
| The cell-surface 5'-nucleotidase CD73 defines a functional T memory cell subset that declines with age. |