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psPAX2 Citations (1636)

Plasmid Article: Trono Lab Packaging and Envelope Plasmids
Unpublished

Articles Citing psPAX2

Articles
CCL2 protects prostate cancer PC3 cells from autophagic death via phosphatidylinositol 3-kinase/AKT-dependent survivin up-regulation. Roca H, Varsos Z, Pienta KJ. J Biol Chem. 2008 Sep 5;283(36):25057-73. doi: 10.1074/jbc.M801073200. Epub 2008 Jul 8. PubMed
A polypyrimidine tract-binding protein-dependent pathway of mRNA stability initiates with CpG activation of primary B cells. Porter JF, Vavassori S, Covey LR. J Immunol. 2008 Sep 1;181(5):3336-45. PubMed
Feeder-free culture of human embryonic stem cells in conditioned medium for efficient genetic modification. Braam SR, Denning C, Matsa E, Young LE, Passier R, Mummery CL. Nat Protoc. 2008;3(9):1435-43. doi: 10.1038/nprot.2008.140. PubMed
The scaffold protein JSAP1 regulates proliferation and differentiation of cerebellar granule cell precursors by modulating JNK signaling. Sato T, Torashima T, Sugihara K, Hirai H, Asano M, Yoshioka K. Mol Cell Neurosci. 2008 Dec;39(4):569-78. doi: 10.1016/j.mcn.2008.08.003. Epub 2008 Aug 30. PubMed
Functional involvement of RINF, retinoid-inducible nuclear factor (CXXC5), in normal and tumoral human myelopoiesis. Pendino F, Nguyen E, Jonassen I, Dysvik B, Azouz A, Lanotte M, Segal-Bendirdjian E, Lillehaug JR. Blood. 2009 Apr 2;113(14):3172-81. doi: 10.1182/blood-2008-07-170035. Epub 2009 Jan 30. PubMed
A functional genomic screen identifies cellular cofactors of hepatitis C virus replication. Tai AW, Benita Y, Peng LF, Kim SS, Sakamoto N, Xavier RJ, Chung RT. Cell Host Microbe. 2009 Mar 19;5(3):298-307. doi: 10.1016/j.chom.2009.02.001. PubMed
Matrix metalloproteinase 12 silencing: a therapeutic approach to treat pathological lung tissue remodeling? Garbacki N, Di Valentin E, Piette J, Cataldo D, Crahay C, Colige A. Pulm Pharmacol Ther. 2009 Aug;22(4):267-78. doi: 10.1016/j.pupt.2009.03.001. Epub 2009 Mar 25. PubMed
TNFAIP3 (A20) is a tumor suppressor gene in Hodgkin lymphoma and primary mediastinal B cell lymphoma. Schmitz R, Hansmann ML, Bohle V, Martin-Subero JI, Hartmann S, Mechtersheimer G, Klapper W, Vater I, Giefing M, Gesk S, Stanelle J, Siebert R, Kuppers R. J Exp Med. 2009 May 11;206(5):981-9. doi: 10.1084/jem.20090528. Epub 2009 Apr 20. PubMed
Tumor microvasculature supports proliferation and expansion of glioma-propagating cells. Borovski T, Verhoeff JJ, ten Cate R, Cameron K, de Vries NA, van Tellingen O, Richel DJ, van Furth WR, Medema JP, Sprick MR. Int J Cancer. 2009 Sep 1;125(5):1222-30. doi: 10.1002/ijc.24408. PubMed
Tubulin polymerization-promoting protein (TPPP/p25) is critical for oligodendrocyte differentiation. Lehotzky A, Lau P, Tokesi N, Muja N, Hudson LD, Ovadi J. Glia. 2010 Jan 15;58(2):157-68. doi: 10.1002/glia.20909. PubMed
Long term non-invasive imaging of embryonic stem cells using reporter genes. Sun N, Lee A, Wu JC. Nat Protoc. 2009;4(8):1192-201. doi: 10.1038/nprot.2009.100. Epub 2009 Jul 23. PubMed
Multipurpose modular lentiviral vectors for RNA interference and transgene expression. Kesireddy V, van der Ven PF, Furst DO. Mol Biol Rep. 2010 Jul;37(6):2863-70. doi: 10.1007/s11033-009-9840-8. Epub 2009 Oct 2. PubMed
Photostimulation of channelrhodopsin-2 expressing ventrolateral medullary neurons increases sympathetic nerve activity and blood pressure in rats. Abbott SB, Stornetta RL, Socolovsky CS, West GH, Guyenet PG. J Physiol. 2009 Dec 1. 587(Pt 23):5613-31. PubMed
Inducible APOBEC3G-Vif double stable cell line as a high-throughput screening platform to identify antiviral compounds. Nowotny B, Schneider T, Pradel G, Schirmeister T, Rethwilm A, Kirschner M. Antimicrob Agents Chemother. 2010 Jan;54(1):78-87. doi: 10.1128/AAC.00775-09. Epub 2009 Oct 19. PubMed
Transcription factors RUNX1 and RUNX3 in the induction and suppressive function of Foxp3+ inducible regulatory T cells. Klunker S, Chong MM, Mantel PY, Palomares O, Bassin C, Ziegler M, Ruckert B, Meiler F, Akdis M, Littman DR, Akdis CA. J Exp Med. 2009 Nov 23;206(12):2701-15. doi: 10.1084/jem.20090596. Epub 2009 Nov 16. PubMed
Neural stem cells as a novel platform for tumor-specific delivery of therapeutic antibodies. Frank RT, Edmiston M, Kendall SE, Najbauer J, Cheung CW, Kassa T, Metz MZ, Kim SU, Glackin CA, Wu AM, Yazaki PJ, Aboody KS. PLoS One. 2009 Dec 15;4(12):e8314. doi: 10.1371/journal.pone.0008314. PubMed
Lentiviral gene transduction in human and mouse NK cell lines. Savan R, Chan T, Young HA. Methods Mol Biol. 2010;612:209-21. doi: 10.1007/978-1-60761-362-6_14. PubMed
HEF1 is a crucial mediator of the proliferative effects of prostaglandin E(2) on colon cancer cells. Xia D, Holla VR, Wang D, Menter DG, DuBois RN. Cancer Res. 2010 Jan 15;70(2):824-31. doi: 10.1158/0008-5472.CAN-09-2105. Epub 2010 Jan 12. PubMed
An inducible Tet-Off-H2B-GFP lentiviral reporter vector for detection and in vivo isolation of label-retaining cells. Falkowska-Hansen B, Kollar J, Gruner BM, Schanz M, Boukamp P, Siveke J, Rethwilm A, Kirschner M. Exp Cell Res. 2010 Jul 1;316(11):1885-95. doi: 10.1016/j.yexcr.2010.02.015. Epub 2010 Feb 18. PubMed
Tumor necrosis factor receptor superfamily member 19 (TNFRSF19) regulates differentiation fate of human mesenchymal (stromal) stem cells through canonical Wnt signaling and C/EBP. Qiu W, Hu Y, Andersen TE, Jafari A, Li N, Chen W, Kassem M. J Biol Chem. 2010 May 7;285(19):14438-49. doi: 10.1074/jbc.M109.052001. Epub 2010 Mar 11. PubMed
Lentiviral vector-mediated transgenesis in human embryonic stem cells. Du ZW, Zhang SC. Methods Mol Biol. 2010;614:127-34. doi: 10.1007/978-1-60761-533-0_8. PubMed
Aire regulates the expression of differentiation-associated genes and self-renewal of embryonic stem cells. Gu B, Zhang J, Chen Q, Tao B, Wang W, Zhou Y, Chen L, Liu Y, Zhang M. Biochem Biophys Res Commun. 2010 Apr 2. 394(2):418-23. PubMed
Functional analysis of the Cdk7.cyclin H.Mat1 complex in mouse embryonic stem cells and embryos. Patel SA, Simon MC. J Biol Chem. 2010 May 14;285(20):15587-98. doi: 10.1074/jbc.M109.081687. Epub 2010 Mar 15. PubMed
Differential splicing of the apoptosis-associated speck like protein containing a caspase recruitment domain (ASC) regulates inflammasomes. Bryan NB, Dorfleutner A, Kramer SJ, Yun C, Rojanasakul Y, Stehlik C. J Inflamm (Lond). 2010 May 18;7:23. doi: 10.1186/1476-9255-7-23. PubMed
Transmembrane protein 147 (TMEM147) is a novel component of the Nicalin-NOMO protein complex. Dettmer U, Kuhn PH, Abou-Ajram C, Lichtenthaler SF, Kruger M, Kremmer E, Haass C, Haffner C. J Biol Chem. 2010 Aug 20;285(34):26174-81. doi: 10.1074/jbc.M110.132548. Epub 2010 Jun 10. PubMed
A novel, retromer-independent role for sorting nexins 1 and 2 in RhoG-dependent membrane remodeling. Prosser DC, Tran D, Schooley A, Wendland B, Ngsee JK. Traffic. 2010 Oct;11(10):1347-62. doi: 10.1111/j.1600-0854.2010.01100.x. PubMed
Two functionally distinct isoforms of TL1A (TNFSF15) generated by differential ectodomain shedding. Muck C, Herndler-Brandstetter D, Micutkova L, Grubeck-Loebenstein B, Jansen-Durr P. J Gerontol A Biol Sci Med Sci. 2010 Nov;65(11):1165-80. doi: 10.1093/gerona/glq129. Epub 2010 Jul 30. PubMed
Expression of miR-33 from an SREBP2 intron inhibits cholesterol export and fatty acid oxidation. Gerin I, Clerbaux LA, Haumont O, Lanthier N, Das AK, Burant CF, Leclercq IA, MacDougald OA, Bommer GT. J Biol Chem. 2010 Oct 29;285(44):33652-61. doi: 10.1074/jbc.M110.152090. Epub 2010 Aug 22. PubMed
Stable overexpression of miRNAs in bone marrow-derived murine mast cells using lentiviral expression vectors. Mayoral RJ, Monticelli S. Methods Mol Biol. 2010;667:205-14. doi: 10.1007/978-1-60761-811-9_14. PubMed
Incremental genetic perturbations to MCM2-7 expression and subcellular distribution reveal exquisite sensitivity of mice to DNA replication stress. Chuang CH, Wallace MD, Abratte C, Southard T, Schimenti JC. PLoS Genet. 2010 Sep 9;6(9):e1001110. doi: 10.1371/journal.pgen.1001110. PubMed
Syntaxin 3 is necessary for cAMP- and cGMP-regulated exocytosis of CFTR: implications for enterotoxigenic diarrhea. Collaco A, Marathe J, Kohnke H, Kravstov D, Ameen N. Am J Physiol Cell Physiol. 2010 Dec;299(6):C1450-60. doi: 10.1152/ajpcell.00029.2010. Epub 2010 Sep 15. PubMed
Role for PKC delta in Fenretinide-Mediated Apoptosis in Lymphoid Leukemia Cells. Ruvolo VR, Karanjeet KB, Schuster TF, Brown R, Deng Y, Hinchcliffe E, Ruvolo PP. J Signal Transduct. 2010 Jan 1;2010:584657. PubMed
Effects of estrogen on the proportion of stem cells in the breast. Simoes BM, Piva M, Iriondo O, Comaills V, Lopez-Ruiz JA, Zabalza I, Mieza JA, Acinas O, Vivanco MD. Breast Cancer Res Treat. 2011 Aug;129(1):23-35. doi: 10.1007/s10549-010-1169-4. Epub 2010 Sep 22. PubMed
ATR and ATRIP are recruited to herpes simplex virus type 1 replication compartments even though ATR signaling is disabled. Mohni KN, Livingston CM, Cortez D, Weller SK. J Virol. 2010 Dec;84(23):12152-64. doi: 10.1128/JVI.01643-10. Epub 2010 Sep 22. PubMed
Dual selection mechanisms drive efficient single-gene reverse genetics for rotavirus. Trask SD, Taraporewala ZF, Boehme KW, Dermody TS, Patton JT. Proc Natl Acad Sci U S A. 2010 Oct 26;107(43):18652-7. doi: 10.1073/pnas.1011948107. Epub 2010 Oct 11. PubMed
The SR-BI partner PDZK1 facilitates hepatitis C virus entry. Eyre NS, Drummer HE, Beard MR. PLoS Pathog. 2010 Oct 7;6(10):e1001130. doi: 10.1371/journal.ppat.1001130. PubMed
Silencing of CDK5 reduces neurofibrillary tangles in transgenic alzheimer's mice. Piedrahita D, Hernandez I, Lopez-Tobon A, Fedorov D, Obara B, Manjunath BS, Boudreau RL, Davidson B, Laferla F, Gallego-Gomez JC, Kosik KS, Cardona-Gomez GP. J Neurosci. 2010 Oct 20;30(42):13966-76. doi: 10.1523/JNEUROSCI.3637-10.2010. PubMed
Large intergenic non-coding RNA-RoR modulates reprogramming of human induced pluripotent stem cells. Loewer S, Cabili MN, Guttman M, Loh YH, Thomas K, Park IH, Garber M, Curran M, Onder T, Agarwal S, Manos PD, Datta S, Lander ES, Schlaeger TM, Daley GQ, Rinn JL. Nat Genet. 2010 Dec;42(12):1113-7. Epub 2010 Nov 7. PubMed

Associated Plasmids

The TRAF-interacting protein (TRIP) is a regulator of keratinocyte proliferation. Almeida S, Ryser S, Obarzanek-Fojt M, Hohl D, Huber M. J Invest Dermatol. 2011 Feb;131(2):349-57. doi: 10.1038/jid.2010.329. Epub 2010 Nov 11. PubMed
Prolylcarboxypeptidase regulates proliferation, autophagy, and resistance to 4-hydroxytamoxifen-induced cytotoxicity in estrogen receptor-positive breast cancer cells. Duan L, Motchoulski N, Danzer B, Davidovich I, Shariat-Madar Z, Levenson VV. J Biol Chem. 2011 Jan 28;286(4):2864-76. doi: 10.1074/jbc.M110.143271. Epub 2010 Nov 17. PubMed
Polypyrimidine tract-binding protein is critical for the turnover and subcellular distribution of CD40 ligand mRNA in CD4+ T cells. Matus-Nicodemos R, Vavassori S, Castro-Faix M, Valentin-Acevedo A, Singh K, Marcelli V, Covey LR. J Immunol. 2011 Feb 15;186(4):2164-71. doi: 10.4049/jimmunol.1003236. Epub 2011 Jan 17. PubMed
Akt1 deletion prevents lung tumorigenesis by mutant K-ras. Hollander MC, Maier CR, Hobbs EA, Ashmore AR, Linnoila RI, Dennis PA. Oncogene. 2011 Apr 14;30(15):1812-21. doi: 10.1038/onc.2010.556. Epub 2011 Jan 17. PubMed
Senescence-associated heterochromatin foci are dispensable for cellular senescence, occur in a cell type- and insult-dependent manner and follow expression of p16(ink4a). Kosar M, Bartkova J, Hubackova S, Hodny Z, Lukas J, Bartek J. Cell Cycle. 2011 Feb 1;10(3):457-68. Epub 2011 Feb 1. PubMed
Yes-associated protein (YAP) transcriptional coactivator functions in balancing growth and differentiation in skin. Zhang H, Pasolli HA, Fuchs E. Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2270-5. doi: 10.1073/pnas.1019603108. Epub 2011 Jan 24. PubMed
JNK signaling promotes intestinal tumorigenesis through activation of mTOR complex 1 in Apc(Delta716) mice. Fujishita T, Aoki M, Taketo MM. Gastroenterology. 2011 May;140(5):1556-63.e6. doi: 10.1053/j.gastro.2011.02.007. Epub 2011 Feb 12. PubMed
High-throughput screening of microscale pitted substrate topographies for enhanced nonviral transfection efficiency in primary human fibroblasts. Adler AF, Speidel AT, Christoforou N, Kolind K, Foss M, Leong KW. Biomaterials. 2011 May;32(14):3611-9. doi: 10.1016/j.biomaterials.2011.01.040. Epub 2011 Feb 21. PubMed
Recapitulation of premature ageing with iPSCs from Hutchinson-Gilford progeria syndrome. Liu GH, Barkho BZ, Ruiz S, Diep D, Qu J, Yang SL, Panopoulos AD, Suzuki K, Kurian L, Walsh C, Thompson J, Boue S, Fung HL, Sancho-Martinez I, Zhang K, Yates J 3rd, Izpisua Belmonte JC. Nature. 2011 Apr 14;472(7342):221-5. doi: 10.1038/nature09879. Epub 2011 Feb 23. PubMed
The neuronal differentiation factor NeuroD1 downregulates the neuronal repellent factor Slit2 expression and promotes cell motility and tumor formation of neuroblastoma. Huang P, Kishida S, Cao D, Murakami-Tonami Y, Mu P, Nakaguro M, Koide N, Takeuchi I, Onishi A, Kadomatsu K. Cancer Res. 2011 Apr 15;71(8):2938-48. doi: 10.1158/0008-5472.CAN-10-3524. Epub 2011 Feb 24. PubMed
SirT3 suppresses hypoxia inducible factor 1alpha and tumor growth by inhibiting mitochondrial ROS production. Bell EL, Emerling BM, Ricoult SJ, Guarente L. Oncogene. 2011 Jun 30;30(26):2986-96. doi: 10.1038/onc.2011.37. Epub 2011 Feb 28. PubMed
Somatic coding mutations in human induced pluripotent stem cells. Gore A, Li Z, Fung HL, Young JE, Agarwal S, Antosiewicz-Bourget J, Canto I, Giorgetti A, Israel MA, Kiskinis E, Lee JH, Loh YH, Manos PD, Montserrat N, Panopoulos AD, Ruiz S, Wilbert ML, Yu J, Kirkness EF, Izpisua Belmonte JC, Rossi DJ, Thomson JA, Eggan K, Daley GQ, Goldstein LS, Zhang K. Nature. 2011 Mar 3;471(7336):63-7. doi: 10.1038/nature09805. PubMed
S1P lyase regulates DNA damage responses through a novel sphingolipid feedback mechanism. Kumar A, Oskouian B, Fyrst H, Zhang M, Paris F, Saba JD. Cell Death Dis. 2011 Feb 10;2:e119. doi: 10.1038/cddis.2011.3. PubMed
Lentiviral vector mediated modification of mesenchymal stem cells & enhanced survival in an in vitro model of ischaemia. McGinley L, McMahon J, Strappe P, Barry F, Murphy M, O'Toole D, O'Brien T. Stem Cell Res Ther. 2011 Mar 7;2(2):12. doi: 10.1186/scrt53. PubMed
Mutation and loss of expression of ARID1A in uterine low-grade endometrioid carcinoma. Guan B, Mao TL, Panuganti PK, Kuhn E, Kurman RJ, Maeda D, Chen E, Jeng YM, Wang TL, Shih IeM. Am J Surg Pathol. 2011 May;35(5):625-32. doi: 10.1097/PAS.0b013e318212782a. PubMed
Anthrax lethal factor activates K(+) channels to induce IL-1beta secretion in macrophages. Thomas J, Epshtein Y, Chopra A, Ordog B, Ghassemi M, Christman JW, Nattel S, Cook JL, Levitan I. J Immunol. 2011 May 1;186(9):5236-43. doi: 10.4049/jimmunol.1001078. Epub 2011 Mar 18. PubMed
Histone demethylase JMJD2B functions as a co-factor of estrogen receptor in breast cancer proliferation and mammary gland development. Kawazu M, Saso K, Tong KI, McQuire T, Goto K, Son DO, Wakeham A, Miyagishi M, Mak TW, Okada H. PLoS One. 2011 Mar 18;6(3):e17830. doi: 10.1371/journal.pone.0017830. PubMed
HIV infection enhances TRAIL-induced cell death in macrophage by down-regulating decoy receptor expression and generation of reactive oxygen species. Zhu DM, Shi J, Liu S, Liu Y, Zheng D. PLoS One. 2011 Apr 5;6(4):e18291. doi: 10.1371/journal.pone.0018291. PubMed
The NLR adaptor ASC/PYCARD regulates DUSP10, mitogen-activated protein kinase (MAPK), and chemokine induction independent of the inflammasome. Taxman DJ, Holley-Guthrie EA, Huang MT, Moore CB, Bergstralh DT, Allen IC, Lei Y, Gris D, Ting JP. J Biol Chem. 2011 Jun 3;286(22):19605-16. doi: 10.1074/jbc.M111.221077. Epub 2011 Apr 12. PubMed
Efficient preparation and labeling of human induced pluripotent stem cells by nanotechnology. Ruan J, Shen J, Wang Z, Ji J, Song H, Wang K, Liu B, Li J, Cui D. Int J Nanomedicine. 2011;6:425-35. doi: 10.2147/IJN.S16498. Epub 2011 Feb 21. PubMed
mTORC1 inhibition increases neurotensin secretion and gene expression through activation of the MEK/ERK/c-Jun pathway in the human endocrine cell line BON. Li J, Liu J, Song J, Wang X, Weiss HL, Townsend CM Jr, Gao T, Evers BM. Am J Physiol Cell Physiol. 2011 Jul;301(1):C213-26. doi: 10.1152/ajpcell.00067.2011. Epub 2011 Apr 20. PubMed
Human cytomegalovirus IE1 protein elicits a type II interferon-like host cell response that depends on activated STAT1 but not interferon-gamma. Knoblach T, Grandel B, Seiler J, Nevels M, Paulus C. PLoS Pathog. 2011 Apr;7(4):e1002016. doi: 10.1371/journal.ppat.1002016. Epub 2011 Apr 14. PubMed
The function of hypoxia-inducible factor (HIF) is independent of the endoplasmic reticulum protein OS-9. Brockmeier U, Platzek C, Schneider K, Patak P, Bernardini A, Fandrey J, Metzen E. PLoS One. 2011 Apr 29;6(4):e19151. doi: 10.1371/journal.pone.0019151. PubMed
Deptor knockdown enhances mTOR Activity and protein synthesis in myocytes and ameliorates disuse muscle atrophy. Kazi AA, Hong-Brown L, Lang SM, Lang CH. Mol Med. 2011 Sep-Oct;17(9-10):925-36. doi: 10.2119/molmed.2011.00070. Epub 2011 May 19. PubMed
Transforming growth factor beta controls CCN3 expression in nucleus pulposus cells of the intervertebral disc. Tran CM, Smith HE, Symes A, Rittie L, Perbal B, Shapiro IM, Risbud MV. Arthritis Rheum. 2011 Oct;63(10):3022-31. doi: 10.1002/art.30468. PubMed
Faster generation of hiPSCs by coupling high-titer lentivirus and column-based positive selection. Dick E, Matsa E, Young LE, Darling D, Denning C. Nat Protoc. 2011 Jun;6(6):701-14. doi: 10.1038/nprot.2011.320. Epub 2011 May 5. PubMed
GPM6B regulates osteoblast function and induction of mineralization by controlling cytoskeleton and matrix vesicle release. Drabek K, van de Peppel J, Eijken M, van Leeuwen JP. J Bone Miner Res. 2011 Sep;26(9):2045-51. doi: 10.1002/jbmr.435. PubMed
L-3-Phosphoserine phosphatase (PSPH) regulates cutaneous squamous cell carcinoma proliferation independent of L-serine biosynthesis. Bachelor MA, Lu Y, Owens DM. J Dermatol Sci. 2011 Sep;63(3):164-72. doi: 10.1016/j.jdermsci.2011.06.001. Epub 2011 Jun 22. PubMed
Hypoxia leads to Na,K-ATPase downregulation via Ca(2+) release-activated Ca(2+) channels and AMPK activation. Gusarova GA, Trejo HE, Dada LA, Briva A, Welch LC, Hamanaka RB, Mutlu GM, Chandel NS, Prakriya M, Sznajder JI. Mol Cell Biol. 2011 Sep;31(17):3546-56. doi: 10.1128/MCB.05114-11. Epub 2011 Jul 5. PubMed
Lentiviral-mediated knockdown during ex vivo erythropoiesis of human hematopoietic stem cells. Palii CG, Pasha R, Brand M. J Vis Exp. 2011 Jul 16;(53). pii: 2813. doi: 10.3791/2813. PubMed
Differentiation and neuro-protective properties of immortalized human tooth germ stem cells. Yalvac ME, Yilmaz A, Mercan D, Aydin S, Dogan A, Arslan A, Demir Z, Salafutdinov II, Shafigullina AK, Sahin F, Rizvanov AA, Palotas A. Neurochem Res. 2011 Dec;36(12):2227-35. doi: 10.1007/s11064-011-0546-7. Epub 2011 Jul 22. PubMed
Endothelial cells create a stem cell niche in glioblastoma by providing NOTCH ligands that nurture self-renewal of cancer stem-like cells. Zhu TS, Costello MA, Talsma CE, Flack CG, Crowley JG, Hamm LL, He X, Hervey-Jumper SL, Heth JA, Muraszko KM, DiMeco F, Vescovi AL, Fan X. Cancer Res. 2011 Sep 15;71(18):6061-72. doi: 10.1158/0008-5472.CAN-10-4269. Epub 2011 Jul 25. PubMed
Transduction of human cells with polymer-complexed ecotropic lentivirus for enhanced biosafety. Barrilleaux B, Knoepfler P. J Vis Exp. 2011 Jul 24;(53). pii: 2822. doi: 10.3791/2822. PubMed
Derivation of induced pluripotent stem cells by lentiviral transduction. Nethercott HE, Brick DJ, Schwartz PH. Methods Mol Biol. 2011;767:67-85. doi: 10.1007/978-1-61779-201-4_6. PubMed
CYP2S1 and CYP2W1 mediate 2-(3,4-dimethoxyphenyl)-5-fluorobenzothiazole (GW-610, NSC 721648) sensitivity in breast and colorectal cancer cells. Tan BS, Tiong KH, Muruhadas A, Randhawa N, Choo HL, Bradshaw TD, Stevens MF, Leong CO. Mol Cancer Ther. 2011 Oct;10(10):1982-92. doi: 10.1158/1535-7163.MCT-11-0391. Epub 2011 Aug 10. PubMed
Effect of Ser-129 phosphorylation on interaction of alpha-synuclein with synaptic and cellular membranes. Visanji NP, Wislet-Gendebien S, Oschipok LW, Zhang G, Aubert I, Fraser PE, Tandon A. J Biol Chem. 2011 Oct 14;286(41):35863-73. Epub 2011 Aug 17. PubMed

Associated Plasmids

Dickkopf-3 maintains the PANC-1 human pancreatic tumor cells in a dedifferentiated state. Zenzmaier C, Hermann M, Hengster P, Berger P. Int J Oncol. 2012 Jan;40(1):40-6. doi: 10.3892/ijo.2011.1180. Epub 2011 Aug 29. PubMed
ARID1A, a factor that promotes formation of SWI/SNF-mediated chromatin remodeling, is a tumor suppressor in gynecologic cancers. Guan B, Wang TL, Shih IeM. Cancer Res. 2011 Nov 1;71(21):6718-27. Epub 2011 Sep 7. PubMed

Associated Plasmids

Daedalus: a robust, turnkey platform for rapid production of decigram quantities of active recombinant proteins in human cell lines using novel lentiviral vectors. Bandaranayake AD, Correnti C, Ryu BY, Brault M, Strong RK, Rawlings DJ. Nucleic Acids Res. 2011 Nov;39(21):e143. doi: 10.1093/nar/gkr706. Epub 2011 Sep 12. PubMed
Modeling sarcomagenesis using multipotent mesenchymal stem cells. Rodriguez R, Rubio R, Menendez P. Cell Res. 2012 Jan;22(1):62-77. doi: 10.1038/cr.2011.157. Epub 2011 Sep 20. PubMed
Inhibition of mTOR kinase by AZD8055 can antagonize chemotherapy-induced cell death through autophagy induction and down-regulation of p62/sequestosome 1. Huang S, Yang ZJ, Yu C, Sinicrope FA. J Biol Chem. 2011 Nov 18;286(46):40002-12. doi: 10.1074/jbc.M111.297432. Epub 2011 Sep 23. PubMed
DNA mismatch repair proteins are required for efficient herpes simplex virus 1 replication. Mohni KN, Mastrocola AS, Bai P, Weller SK, Heinen CD. J Virol. 2011 Dec;85(23):12241-53. doi: 10.1128/JVI.05487-11. Epub 2011 Sep 28. PubMed
HIF-1alpha and HIF-2alpha degradation is differentially regulated in nucleus pulposus cells of the intervertebral disc. Fujita N, Chiba K, Shapiro IM, Risbud MV. J Bone Miner Res. 2012 Feb;27(2):401-12. doi: 10.1002/jbmr.538. PubMed
Suppression of BCL-2 synergizes cisplatin sensitivity in nasopharyngeal carcinoma cells. Low SY, Tan BS, Choo HL, Tiong KH, Khoo AS, Leong CO. Cancer Lett. 2012 Jan 28;314(2):166-75. doi: 10.1016/j.canlet.2011.09.025. Epub 2011 Oct 8. PubMed
Disruption of Wnt planar cell polarity signaling by aberrant accumulation of the MetAP-2 substrate Rab37. Sundberg TB, Darricarrere N, Cirone P, Li X, McDonald L, Mei X, Westlake CJ, Slusarski DC, Beynon RJ, Crews CM. Chem Biol. 2011 Oct 28;18(10):1300-11. doi: 10.1016/j.chembiol.2011.07.020. PubMed
Optimal functional levels of activation-induced deaminase specifically require the Hsp40 DnaJa1. Orthwein A, Zahn A, Methot SP, Godin D, Conticello SG, Terada K, Di Noia JM. EMBO J. 2012 Feb 1;31(3):679-91. doi: 10.1038/emboj.2011.417. Epub 2011 Nov 15. PubMed
FGF signalling inhibits neural induction in human embryonic stem cells. Greber B, Coulon P, Zhang M, Moritz S, Frank S, Muller-Molina AJ, Arauzo-Bravo MJ, Han DW, Pape HC, Scholer HR. EMBO J. 2011 Nov 15;30(24):4874-84. doi: 10.1038/emboj.2011.407. PubMed
Novel reporter systems for facile evaluation of I-SceI-mediated genome editing. Munoz NM, Beard BC, Ryu BY, Luche RM, Trobridge GD, Rawlings DJ, Scharenberg AM, Kiem HP. Nucleic Acids Res. 2012 Jan;40(2):e14. doi: 10.1093/nar/gkr897. Epub 2011 Nov 21. PubMed
Defining MAP3 kinases required for MDA-MB-231 cell tumor growth and metastasis. Cronan MR, Nakamura K, Johnson NL, Granger DA, Cuevas BD, Wang JG, Mackman N, Scott JE, Dohlman HG, Johnson GL. Oncogene. 2012 Aug 23;31(34):3889-900. doi: 10.1038/onc.2011.544. Epub 2011 Dec 5. PubMed
Development of immortalized hepatocyte-like cells from hMSCs. Wongkajornsilp A, Sa-Ngiamsuntorn K, Hongeng S. Methods Mol Biol. 2012;826:73-87. doi: 10.1007/978-1-61779-468-1_7. PubMed
Efficient conversion of astrocytes to functional midbrain dopaminergic neurons using a single polycistronic vector. Addis RC, Hsu FC, Wright RL, Dichter MA, Coulter DA, Gearhart JD. PLoS One. 2011;6(12):e28719. doi: 10.1371/journal.pone.0028719. Epub 2011 Dec 9. PubMed

Associated Plasmids

Modulation of Wnt/beta-catenin signaling in human embryonic stem cells using a 3-D microwell array. Azarin SM, Lian X, Larson EA, Popelka HM, de Pablo JJ, Palecek SP. Biomaterials. 2012 Mar;33(7):2041-9. Epub 2011 Dec 15. PubMed

Associated Plasmids

Pygo2 regulates histone gene expression and H3 K56 acetylation in human mammary epithelial cells. Gu B, Watanabe K, Dai X. Cell Cycle. 2012 Jan 1;11(1):79-87. doi: 10.4161/cc.11.1.18402. Epub 2012 Jan 1. PubMed
Reprogramming of mouse, rat, pig, and human fibroblasts into iPS cells. Rajarajan K, Engels MC, Wu SM. Curr Protoc Mol Biol. 2012 Jan;Chapter 23:Unit 23.15.. doi: 10.1002/0471142727.mb2315s97. PubMed
IGF2BP1 promotes cell migration by regulating MK5 and PTEN signaling. Stohr N, Kohn M, Lederer M, Glass M, Reinke C, Singer RH, Huttelmaier S. Genes Dev. 2012 Jan 15;26(2):176-89. doi: 10.1101/gad.177642.111. PubMed
The aryl hydrocarbon receptor contributes to the proliferation of human medulloblastoma cells. Dever DP, Opanashuk LA. Mol Pharmacol. 2012 May;81(5):669-78. doi: 10.1124/mol.111.077305. Epub 2012 Feb 6. PubMed
Potassium channel mutant KCNJ5 T158A expression in HAC-15 cells increases aldosterone synthesis. Oki K, Plonczynski MW, Luis Lam M, Gomez-Sanchez EP, Gomez-Sanchez CE. Endocrinology. 2012 Apr;153(4):1774-82. doi: 10.1210/en.2011-1733. Epub 2012 Feb 7. PubMed
Outgrowth of single oncogene-expressing cells from suppressive epithelial environments. Leung CT, Brugge JS. Nature. 2012 Feb 8;482(7385):410-3. doi: 10.1038/nature10826. PubMed
Retinoblastoma tumor-suppressor protein phosphorylation and inactivation depend on direct interaction with Pin1. Rizzolio F, Lucchetti C, Caligiuri I, Marchesi I, Caputo M, Klein-Szanto AJ, Bagella L, Castronovo M, Giordano A. Cell Death Differ. 2012 Jul;19(7):1152-61. doi: 10.1038/cdd.2011.202. Epub 2012 Feb 10. PubMed
Angiogenic properties of myofibroblasts isolated from normal human skin wounds. Mayrand D, Laforce-Lavoie A, Larochelle S, Langlois A, Genest H, Roy M, Moulin VJ. Angiogenesis. 2012 Jun;15(2):199-212. doi: 10.1007/s10456-012-9253-5. Epub 2012 Feb 18. PubMed
Real-time bioluminescence and tomographic imaging of gastric cancer in a novel orthotopic mouse model. Hu H, Liu J, Yao L, Yin J, Su N, Liu X, Cao F, Liang J, Nie Y, Wu K. Oncol Rep. 2012 Jun;27(6):1937-43. doi: 10.3892/or.2012.1713. Epub 2012 Mar 7. PubMed
Expression of prolyl hydroxylases (PHDs) is selectively controlled by HIF-1 and HIF-2 proteins in nucleus pulposus cells of the intervertebral disc: distinct roles of PHD2 and PHD3 proteins in controlling HIF-1alpha activity in hypoxia. Fujita N, Markova D, Anderson DG, Chiba K, Toyama Y, Shapiro IM, Risbud MV. J Biol Chem. 2012 May 11;287(20):16975-86. doi: 10.1074/jbc.M111.334466. Epub 2012 Mar 26. PubMed
3' self-inactivating long terminal repeat inserts for the modulation of transgene expression from lentiviral vectors. Manic G, Maurin-Marlin A, Galluzzi L, Subra F, Mouscadet JF, Bury-Mone S. Hum Gene Ther Methods. 2012 Apr;23(2):84-97. doi: 10.1089/hgtb.2011.154. Epub 2012 Mar 28. PubMed
Pathogen-induced human TH17 cells produce IFN-gamma or IL-10 and are regulated by IL-1beta. Zielinski CE, Mele F, Aschenbrenner D, Jarrossay D, Ronchi F, Gattorno M, Monticelli S, Lanzavecchia A, Sallusto F. Nature. 2012 Apr 26;484(7395):514-8. doi: 10.1038/nature10957. PubMed
Heightened expression of MICA enhances the cytotoxicity of NK cells or CD8+T cells to human corneal epithelium in vitro. Hong J, Qiu T, Qian T, Li G, Yu X, Chen J, Le Q, Sun X, Xu J. BMC Ophthalmol. 2012 Apr 4;12:6. doi: 10.1186/1471-2415-12-6. PubMed
Zfp296 is a novel, pluripotent-specific reprogramming factor. Fischedick G, Klein DC, Wu G, Esch D, Hoing S, Han DW, Reinhardt P, Hergarten K, Tapia N, Scholer HR, Sterneckert JL. PLoS One. 2012;7(4):e34645. doi: 10.1371/journal.pone.0034645. Epub 2012 Apr 2. PubMed
Carbonic anhydrase III regulates peroxisome proliferator-activated receptor-gamma2. Mitterberger MC, Kim G, Rostek U, Levine RL, Zwerschke W. Exp Cell Res. 2012 May 1;318(8):877-86. doi: 10.1016/j.yexcr.2012.02.011. Epub 2012 Feb 28. PubMed
Myosin Ia is required for CFTR brush border membrane trafficking and ion transport in the mouse small intestine. Kravtsov DV, Caputo C, Collaco A, Hoekstra N, Egan ME, Mooseker MS, Ameen NA. Traffic. 2012 Aug;13(8):1072-82. doi: 10.1111/j.1600-0854.2012.01368.x. Epub 2012 May 8. PubMed
Nanotopography as modulator of human mesenchymal stem cell function. Kulangara K, Yang Y, Yang J, Leong KW. Biomaterials. 2012 Jul;33(20):4998-5003. doi: 10.1016/j.biomaterials.2012.03.053. Epub 2012 Apr 18. PubMed
Aire promotes the self-renewal of embryonic stem cells through Lin28. Bin G, Jiarong Z, Shihao W, Xiuli S, Cheng X, Liangbiao C, Ming Z. Stem Cells Dev. 2012 Oct 10;21(15):2878-90. doi: 10.1089/scd.2012.0097. Epub 2012 Jun 11. PubMed
LASS2 enhances chemosensitivity of breast cancer by counteracting acidic tumor microenvironment through inhibiting activity of V-ATPase proton pump. Fan S, Niu Y, Tan N, Wu Z, Wang Y, You H, Ke R, Song J, Shen Q, Wang W, Yao G, Shu H, Lin H, Yao M, Zhang Z, Gu J, Qin W. Oncogene. 2013 Mar 28;32(13):1682-90. doi: 10.1038/onc.2012.183. Epub 2012 May 14. PubMed
Identification of novel human damage response proteins targeted through yeast orthology. Svensson JP, Fry RC, Wang E, Somoza LA, Samson LD. PLoS One. 2012;7(5):e37368. doi: 10.1371/journal.pone.0037368. Epub 2012 May 16. PubMed
MARCKS regulates growth and radiation sensitivity and is a novel prognostic factor for glioma. Jarboe JS, Anderson JC, Duarte CW, Mehta T, Nowsheen S, Hicks PH, Whitley AC, Rohrbach TD, McCubrey RO, Chiu S, Burleson TM, Bonner JA, Gillespie GY, Yang ES, Willey CD. Clin Cancer Res. 2012 Jun 1;18(11):3030-41. doi: 10.1158/1078-0432.CCR-11-3091. Epub 2012 May 22. PubMed
DLK1(PREF1) is a negative regulator of adipogenesis in CD105(+)/CD90(+)/CD34(+)/CD31(-)/FABP4(-) adipose-derived stromal cells from subcutaneous abdominal fat pats of adult women. Mitterberger MC, Lechner S, Mattesich M, Kaiser A, Probst D, Wenger N, Pierer G, Zwerschke W. Stem Cell Res. 2012 Jul;9(1):35-48. doi: 10.1016/j.scr.2012.04.001. Epub 2012 Apr 17. PubMed
Smad3 controls beta-1,3-glucuronosyltransferase 1 expression in rat nucleus pulposus cells: implications of dysregulated expression in disc disease. Wu Q, Wang J, Skubutyte R, Kepler CK, Huang Z, Anderson DG, Shapiro IM, Risbud MV. Arthritis Rheum. 2012 Oct;64(10):3324-33. doi: 10.1002/art.34570. PubMed
Morphology of axonal projections from the high vocal center to vocal motor cortex in songbirds. Yip ZC, Miller-Sims VC, Bottjer SW. J Comp Neurol. 2012 Aug 15;520(12):2742-56. doi: 10.1002/cne.23084. PubMed
A versatile lentiviral expression system to identify mammalian protein-protein interactions. Mak AB, Moffat J. Methods. 2012 Aug;57(4):409-16. doi: 10.1016/j.ymeth.2012.06.005. Epub 2012 Jun 17. PubMed
Phosphorylation of p65(RelA) on Ser(547) by ATM represses NF-kappaB-dependent transcription of specific genes after genotoxic stress. Sabatel H, Di Valentin E, Gloire G, Dequiedt F, Piette J, Habraken Y. PLoS One. 2012;7(6):e38246. doi: 10.1371/journal.pone.0038246. Epub 2012 Jun 8. PubMed
Iterative capped assembly: rapid and scalable synthesis of repeat-module DNA such as TAL effectors from individual monomers. Briggs AW, Rios X, Chari R, Yang L, Zhang F, Mali P, Church GM. Nucleic Acids Res. 2012 Aug;40(15):e117. doi: 10.1093/nar/gks624. Epub 2012 Jun 26. PubMed
Role of mismatch repair enzymes in GAA.TTC triplet-repeat expansion in Friedreich ataxia induced pluripotent stem cells. Du J, Campau E, Soragni E, Ku S, Puckett JW, Dervan PB, Gottesfeld JM. J Biol Chem. 2012 Aug 24;287(35):29861-72. doi: 10.1074/jbc.M112.391961. Epub 2012 Jul 13. PubMed
Expression of the PTTG1 oncogene is associated with aggressive clear cell renal cell carcinoma. Wondergem B, Zhang Z, Huang D, Ong CK, Koeman J, Hof DV, Petillo D, Ooi A, Anema J, Lane B, Kahnoski RJ, Furge KA, Teh BT. Cancer Res. 2012 Sep 1;72(17):4361-71. doi: 10.1158/0008-5472.CAN-11-2330. Epub 2012 Jul 17. PubMed
Cytokine secretion by CD4+ T cells at the immunological synapse requires Cdc42-dependent local actin remodeling but not microtubule organizing center polarity. Chemin K, Bohineust A, Dogniaux S, Tourret M, Guegan S, Miro F, Hivroz C. J Immunol. 2012 Sep 1;189(5):2159-68. doi: 10.4049/jimmunol.1200156. Epub 2012 Jul 20. PubMed
ASC-dependent RIP2 kinase regulates reduced PGE2 production in chronic periodontitis. Taxman DJ, Lei Y, Zhang S, Holley-Guthrie E, Offenbacher S, Ting JP. J Dent Res. 2012 Sep;91(9):877-82. doi: 10.1177/0022034512454541. Epub 2012 Jul 24. PubMed
AV-65, a novel Wnt/beta-catenin signal inhibitor, successfully suppresses progression of multiple myeloma in a mouse model. Yao H, Ashihara E, Strovel JW, Nakagawa Y, Kuroda J, Nagao R, Tanaka R, Yokota A, Takeuchi M, Hayashi Y, Shimazaki C, Taniwaki M, Strand K, Padia J, Hirai H, Kimura S, Maekawa T. Blood Cancer J. 2011 Nov;1(11):e43. doi: 10.1038/bcj.2011.41. Epub 2011 Nov 4. PubMed
Synthesis and evaluation of hybrid drugs for a potential HIV/AIDS-malaria combination therapy. Aminake MN, Mahajan A, Kumar V, Hans R, Wiesner L, Taylor D, de Kock C, Grobler A, Smith PJ, Kirschner M, Rethwilm A, Pradel G, Chibale K. Bioorg Med Chem. 2012 Sep 1;20(17):5277-89. doi: 10.1016/j.bmc.2012.06.038. Epub 2012 Jun 29. PubMed
Genetic background affects induced pluripotent stem cell generation. Schnabel LV, Abratte CM, Schimenti JC, Southard TL, Fortier LA. Stem Cell Res Ther. 2012 Aug 3;3(4):30. doi: 10.1186/scrt121. PubMed
Inhibiting adipose tissue lipogenesis reprograms thermogenesis and PPARgamma activation to decrease diet-induced obesity. Lodhi IJ, Yin L, Jensen-Urstad AP, Funai K, Coleman T, Baird JH, El Ramahi MK, Razani B, Song H, Fu-Hsu F, Turk J, Semenkovich CF. Cell Metab. 2012 Aug 8;16(2):189-201. PubMed
Androgen receptor serine 81 mediates Pin1 interaction and activity. La Montagna R, Caligiuri I, Maranta P, Lucchetti C, Esposito L, Paggi MG, Toffoli G, Rizzolio F, Giordano A. Cell Cycle. 2012 Sep 15;11(18):3415-20. doi: 10.4161/cc.21730. Epub 2012 Aug 16. PubMed
Peroxiredoxin 1 functions as a signal peroxidase to receive, transduce, and transmit peroxide signals in mammalian cells. Jarvis RM, Hughes SM, Ledgerwood EC. Free Radic Biol Med. 2012 Oct 1;53(7):1522-30. doi: 10.1016/j.freeradbiomed.2012.08.001. Epub 2012 Aug 8. PubMed
Elevating SOX2 levels deleteriously affects the growth of medulloblastoma and glioblastoma cells. Cox JL, Wilder PJ, Desler M, Rizzino A. PLoS One. 2012;7(8):e44087. doi: 10.1371/journal.pone.0044087. Epub 2012 Aug 28. PubMed
Prolyl hydroxylase 3 (PHD3) modulates catabolic effects of tumor necrosis factor-alpha (TNF-alpha) on cells of the nucleus pulposus through co-activation of nuclear factor kappaB (NF-kappaB)/p65 signaling. Fujita N, Gogate SS, Chiba K, Toyama Y, Shapiro IM, Risbud MV. J Biol Chem. 2012 Nov 16;287(47):39942-53. doi: 10.1074/jbc.M112.375964. Epub 2012 Sep 4. PubMed
Autophagy plays a protective role in endoplasmic reticulum stress-mediated pancreatic beta cell death. Bartolome A, Guillen C, Benito M. Autophagy. 2012 Dec;8(12):1757-68. doi: 10.4161/auto.21994. Epub 2012 Sep 5. PubMed
AIF-mediated caspase-independent necroptosis requires ATM and DNA-PK-induced histone H2AX Ser139 phosphorylation. Baritaud M, Cabon L, Delavallee L, Galan-Malo P, Gilles ME, Brunelle-Navas MN, Susin SA. Cell Death Dis. 2012 Sep 13;3:e390. doi: 10.1038/cddis.2012.120. PubMed
The ablation of EZH2 uncovers its crucial role in rhabdomyosarcoma formation. Marchesi I, Fiorentino FP, Rizzolio F, Giordano A, Bagella L. Cell Cycle. 2012 Oct 15;11(20):3828-36. doi: 10.4161/cc.22025. Epub 2012 Sep 14. PubMed
Calcium-permeable alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors trigger neuronal nitric-oxide synthase activation to promote nerve cell death in an Src kinase-dependent fashion. Socodato R, Santiago FN, Portugal CC, Domingues AF, Santiago AR, Relvas JB, Ambrosio AF, Paes-de-Carvalho R. J Biol Chem. 2012 Nov 9;287(46):38680-94. doi: 10.1074/jbc.M112.353961. Epub 2012 Sep 19. PubMed
Codon-usage-based inhibition of HIV protein synthesis by human schlafen 11. Li M, Kao E, Gao X, Sandig H, Limmer K, Pavon-Eternod M, Jones TE, Landry S, Pan T, Weitzman MD, David M. Nature. 2012 Nov 1;491(7422):125-8. doi: 10.1038/nature11433. Epub 2012 Sep 23. PubMed
The cellular ataxia telangiectasia-mutated kinase promotes epstein-barr virus lytic reactivation in response to multiple different types of lytic reactivation-inducing stimuli. Hagemeier SR, Barlow EA, Meng Q, Kenney SC. J Virol. 2012 Dec;86(24):13360-70. doi: 10.1128/JVI.01850-12. Epub 2012 Sep 26. PubMed
Identification of alternatively translated Tetherin isoforms with differing antiviral and signaling activities. Cocka LJ, Bates P. PLoS Pathog. 2012 Sep;8(9):e1002931. doi: 10.1371/journal.ppat.1002931. Epub 2012 Sep 27. PubMed
Synergistic antitumor effects of endostar in combination with oxaliplatin via inhibition of HIF and CXCR4 in the colorectal cell line SW1116. Jin F, Ji H, Jia C, Brockmeier U, Hermann DM, Metzen E, Zhu Y, Chi B. PLoS One. 2012;7(10):e47161. doi: 10.1371/journal.pone.0047161. Epub 2012 Oct 10. PubMed
Functional analysis of in-frame indel ARID1A mutations reveals new regulatory mechanisms of its tumor suppressor functions. Guan B, Gao M, Wu CH, Wang TL, Shih IeM. Neoplasia. 2012 Oct;14(10):986-93. PubMed
Influenza virus induces apoptosis via BAD-mediated mitochondrial dysregulation. Tran AT, Cortens JP, Du Q, Wilkins JA, Coombs KM. J Virol. 2013 Jan;87(2):1049-60. doi: 10.1128/JVI.02017-12. Epub 2012 Nov 7. PubMed
Histone deacetylase inhibition activates transgene expression from integration-defective lentiviral vectors in dividing and non-dividing cells. Pelascini LP, Janssen JM, Goncalves MA. Hum Gene Ther. 2013 Jan;24(1):78-96. doi: 10.1089/hum.2012.069. Epub 2012 Dec 11. PubMed
Impact of sustained RNAi-mediated suppression of cellular cofactor Tat-SF1 on HIV-1 replication in CD4+ T cells. Green VA, Arbuthnot P, Weinberg MS. Virol J. 2012 Nov 15;9:272. doi: 10.1186/1743-422X-9-272. PubMed
Comparison of mixed and lamellar coculture spatial arrangements for tissue engineering capillary networks in vitro. Peters EB, Christoforou N, Leong KW, Truskey GA. Tissue Eng Part A. 2013 Mar;19(5-6):697-706. doi: 10.1089/ten.tea.2011.0704. Epub 2012 Nov 21. PubMed
Role of early B-cell factor 1 (EBF1) in Hodgkin lymphoma. Bohle V, Doring C, Hansmann ML, Kuppers R. Leukemia. 2013 Mar;27(3):671-9. doi: 10.1038/leu.2012.280. Epub 2012 Oct 1. PubMed
Insulin inhibits cardiac mesoderm, not mesendoderm, formation during cardiac differentiation of human pluripotent stem cells and modulation of canonical Wnt signaling can rescue this inhibition. Lian X, Zhang J, Zhu K, Kamp TJ, Palecek SP. Stem Cells. 2013 Mar;31(3):447-57. doi: 10.1002/stem.1289. PubMed
Tissue-specific interaction of Per1/2 and Dec2 in the regulation of fibroblast circadian rhythms. Tsang AH, Sanchez-Moreno C, Bode B, Rossner MJ, Garaulet M, Oster H. J Biol Rhythms. 2012 Dec;27(6):478-89. doi: 10.1177/0748730412462838. PubMed
Tumor necrosis factor alpha- and interleukin-1beta-dependent induction of CCL3 expression by nucleus pulposus cells promotes macrophage migration through CCR1. Wang J, Tian Y, Phillips KL, Chiverton N, Haddock G, Bunning RA, Cross AK, Shapiro IM, Le Maitre CL, Risbud MV. Arthritis Rheum. 2013 Mar;65(3):832-42. doi: 10.1002/art.37819. PubMed
Directed cardiomyocyte differentiation from human pluripotent stem cells by modulating Wnt/beta-catenin signaling under fully defined conditions. Lian X, Zhang J, Azarin SM, Zhu K, Hazeltine LB, Bao X, Hsiao C, Kamp TJ, Palecek SP. Nat Protoc. 2013 Jan;8(1):162-75. doi: 10.1038/nprot.2012.150. Epub 2012 Dec 20. PubMed
Ribosomal protein S25 dependency reveals a common mechanism for diverse internal ribosome entry sites and ribosome shunting. Hertz MI, Landry DM, Willis AE, Luo G, Thompson SR. Mol Cell Biol. 2013 Mar;33(5):1016-26. doi: 10.1128/MCB.00879-12. Epub 2012 Dec 28. PubMed
Differential integrity of TALE nuclease genes following adenoviral and lentiviral vector gene transfer into human cells. Holkers M, Maggio I, Liu J, Janssen JM, Miselli F, Mussolino C, Recchia A, Cathomen T, Goncalves MA. Nucleic Acids Res. 2013 Mar 1;41(5):e63. doi: 10.1093/nar/gks1446. Epub 2012 Dec 28. PubMed
RNA-interacting proteins act as site-specific repressors of ADAR2-mediated RNA editing and fluctuate upon neuronal stimulation. Tariq A, Garncarz W, Handl C, Balik A, Pusch O, Jantsch MF. Nucleic Acids Res. 2013 Feb 1;41(4):2581-93. doi: 10.1093/nar/gks1353. Epub 2012 Dec 28. PubMed
Gene-specific factors determine mitotic expression and bookmarking via alternate regulatory elements. Arampatzi P, Gialitakis M, Makatounakis T, Papamatheakis J. Nucleic Acids Res. 2013 Feb 1;41(4):2202-15. doi: 10.1093/nar/gks1365. Epub 2013 Jan 8. PubMed
Role of C/EBPbeta-LAP and C/EBPbeta-LIP in early adipogenic differentiation of human white adipose-derived progenitors and at later stages in immature adipocytes. Lechner S, Mitterberger MC, Mattesich M, Zwerschke W. Differentiation. 2013 Jan;85(1-2):20-31. doi: 10.1016/j.diff.2012.11.001. Epub 2013 Jan 11. PubMed
RNAi-mediated gene function analysis in skin. Beronja S, Fuchs E. Methods Mol Biol. 2013;961:351-61. doi: 10.1007/978-1-62703-227-8_23. PubMed
An analysis and validation pipeline for large-scale RNAi-based screens. Plank M, Hu G, Silva AS, Wood SH, Hesketh EE, Janssens G, Macedo A, de Magalhaes JP, Church GM. Sci Rep. 2013;3:1076. doi: 10.1038/srep01076. Epub 2013 Jan 16. PubMed
Gene transduction in human monocyte-derived dendritic cells using lentiviral vectors. Satoh T, Manel N. Methods Mol Biol. 2013;960:401-9. doi: 10.1007/978-1-62703-218-6_30. PubMed
Nonviral direct conversion of primary mouse embryonic fibroblasts to neuronal cells. Adler AF, Grigsby CL, Kulangara K, Wang H, Yasuda R, Leong KW. Mol Ther Nucleic Acids. 2012 Jul 10;1:e32. doi: 10.1038/mtna.2012.25. PubMed
alpha-Synuclein membrane association is regulated by the Rab3a recycling machinery and presynaptic activity. Chen RH, Wislet-Gendebien S, Samuel F, Visanji NP, Zhang G, Marsilio D, Langman T, Fraser PE, Tandon A. J Biol Chem. 2013 Mar 15;288(11):7438-49. doi: 10.1074/jbc.M112.439497. Epub 2013 Jan 23. PubMed
A high-throughput screen to identify enhancers of ADAR-mediated RNA-editing. Garncarz W, Tariq A, Handl C, Pusch O, Jantsch MF. RNA Biol. 2013 Feb;10(2):192-204. doi: 10.4161/rna.23208. Epub 2013 Jan 25. PubMed
Identification of CDCP1 as a hypoxia-inducible factor 2alpha (HIF-2alpha) target gene that is associated with survival in clear cell renal cell carcinoma patients. Emerling BM, Benes CH, Poulogiannis G, Bell EL, Courtney K, Liu H, Choo-Wing R, Bellinger G, Tsukazawa KS, Brown V, Signoretti S, Soltoff SP, Cantley LC. Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3483-8. doi: 10.1073/pnas.1222435110. Epub 2013 Feb 1. PubMed
Hypertonic stress promotes autophagy and microtubule-dependent autophagosomal clusters. Nunes P, Ernandez T, Roth I, Qiao X, Strebel D, Bouley R, Charollais A, Ramadori P, Foti M, Meda P, Feraille E, Brown D, Hasler U. Autophagy. 2013 Apr;9(4):550-67. doi: 10.4161/auto.23662. Epub 2013 Feb 4. PubMed
The prolyl isomerase Pin1 acts synergistically with CDK2 to regulate the basal activity of estrogen receptor alpha in breast cancer. Lucchetti C, Caligiuri I, Toffoli G, Giordano A, Rizzolio F. PLoS One. 2013;8(2):e55355. doi: 10.1371/journal.pone.0055355. Epub 2013 Feb 4. PubMed
CD44 is involved in mineralization of dental pulp cells. Chen KL, Huang YY, Lung J, Yeh YY, Yuan K. J Endod. 2013 Mar;39(3):351-6. doi: 10.1016/j.joen.2012.11.043. Epub 2013 Jan 16. PubMed
Identification of tribbles-1 as a novel binding partner of Foxp3 in regulatory T cells. Dugast E, Kiss-Toth E, Docherty L, Danger R, Chesneau M, Pichard V, Judor JP, Pettre S, Conchon S, Soulillou JP, Brouard S, Ashton-Chess J. J Biol Chem. 2013 Apr 5;288(14):10051-60. doi: 10.1074/jbc.M112.448654. Epub 2013 Feb 15. PubMed
hTERT extends the life of human fibroblasts without compromising type I interferon signaling. Smith MC, Goddard ET, Perusina Lanfranca M, Davido DJ. PLoS One. 2013;8(3):e58233. doi: 10.1371/journal.pone.0058233. Epub 2013 Mar 5. PubMed
Canonical Wnt signaling induces BMP-4 to specify slow myofibrogenesis of fetal myoblasts. Kuroda K, Kuang S, Taketo MM, Rudnicki MA. Skelet Muscle. 2013 Mar 5;3(1):5. doi: 10.1186/2044-5040-3-5. PubMed
Sox10-MCS5 enhancer dynamically tracks human oligodendrocyte progenitor fate. Pol SU, Lang JK, O'Bara MA, Cimato TR, McCallion AS, Sim FJ. Exp Neurol. 2013 Sep;247:694-702. doi: 10.1016/j.expneurol.2013.03.010. Epub 2013 Mar 16. PubMed

Associated Plasmids

Hypoxia-inducible factor (HIF)-1alpha and CCN2 form a regulatory circuit in hypoxic nucleus pulposus cells: CCN2 suppresses HIF-1alpha level and transcriptional activity. Tran CM, Fujita N, Huang BL, Ong JR, Lyons KM, Shapiro IM, Risbud MV. J Biol Chem. 2013 May 3;288(18):12654-66. doi: 10.1074/jbc.M112.448860. Epub 2013 Mar 24. PubMed
The ULb' region of the human cytomegalovirus genome confers an increased requirement for the viral protein kinase UL97. Wang D, Li G, Schauflinger M, Nguyen CC, Hall ED, Yurochko AD, von Einem J, Kamil JP. J Virol. 2013 Jun;87(11):6359-76. doi: 10.1128/JVI.03477-12. Epub 2013 Mar 27. PubMed
Nutrient-dependent phosphorylation channels lipid synthesis to regulate PPARalpha. Jensen-Urstad AP, Song H, Lodhi IJ, Funai K, Yin L, Coleman T, Semenkovich CF. J Lipid Res. 2013 Jul;54(7):1848-59. doi: 10.1194/jlr.M036103. Epub 2013 Apr 13. PubMed
Inflammatory cytokines induce NOTCH signaling in nucleus pulposus cells: implications in intervertebral disc degeneration. Wang H, Tian Y, Wang J, Phillips KL, Binch AL, Dunn S, Cross A, Chiverton N, Zheng Z, Shapiro IM, Le Maitre CL, Risbud MV. J Biol Chem. 2013 Jun 7;288(23):16761-74. doi: 10.1074/jbc.M112.446633. Epub 2013 Apr 15. PubMed
Optimization of direct fibroblast reprogramming to cardiomyocytes using calcium activity as a functional measure of success. Addis RC, Ifkovits JL, Pinto F, Kellam LD, Esteso P, Rentschler S, Christoforou N, Epstein JA, Gearhart JD. J Mol Cell Cardiol. 2013 Apr 13;60C:97-106. doi: 10.1016/j.yjmcc.2013.04.004. PubMed

Associated Plasmids

Inflammatory cytokines associated with degenerative disc disease control aggrecanase-1 (ADAMTS-4) expression in nucleus pulposus cells through MAPK and NF-kappaB. Tian Y, Yuan W, Fujita N, Wang J, Wang H, Shapiro IM, Risbud MV. Am J Pathol. 2013 Jun;182(6):2310-21. doi: 10.1016/j.ajpath.2013.02.037. Epub 2013 Apr 17. PubMed
6-Shogaol inhibits breast and colon cancer cell proliferation through activation of peroxisomal proliferator activated receptor gamma (PPARgamma). Tan BS, Kang O, Mai CW, Tiong KH, Khoo AS, Pichika MR, Bradshaw TD, Leong CO. Cancer Lett. 2013 Aug 9;336(1):127-39. doi: 10.1016/j.canlet.2013.04.014. Epub 2013 Apr 21. PubMed
Prox1 directly interacts with LSD1 and recruits the LSD1/NuRD complex to epigenetically co-repress CYP7A1 transcription. Ouyang H, Qin Y, Liu Y, Xie Y, Liu J. PLoS One. 2013 Apr 23;8(4):e62192. doi: 10.1371/journal.pone.0062192. Print 2013. PubMed
Efficacious proteasome/HDAC inhibitor combination therapy for primary effusion lymphoma. Bhatt S, Ashlock BM, Toomey NL, Diaz LA, Mesri EA, Lossos IS, Ramos JC. J Clin Invest. 2013 Jun;123(6):2616-28. doi: 10.1172/JCI64503. Epub 2013 May 1. PubMed
Dyskeratosis congenita mutations in dyskerin SUMOylation consensus sites lead to impaired telomerase RNA accumulation and telomere defects. Brault ME, Lauzon C, Autexier C. Hum Mol Genet. 2013 Sep 1;22(17):3498-507. doi: 10.1093/hmg/ddt204. Epub 2013 May 8. PubMed
The B-cell-specific transcription factor and master regulator Pax5 promotes Epstein-Barr virus latency by negatively regulating the viral immediate early protein BZLF1. Raver RM, Panfil AR, Hagemeier SR, Kenney SC. J Virol. 2013 Jul;87(14):8053-63. doi: 10.1128/JVI.00546-13. Epub 2013 May 15. PubMed
Lentiviral vector production, titration, and transduction of primary neurons. Ding B, Kilpatrick DL. Methods Mol Biol. 2013;1018:119-31. doi: 10.1007/978-1-62703-444-9_12. PubMed
TAL effector nucleases induce mutations at a pre-selected location in the genome of primary barley transformants. Wendt T, Holm PB, Starker CG, Christian M, Voytas DF, Brinch-Pedersen H, Holme IB. Plant Mol Biol. 2013 Oct;83(3):279-85. doi: 10.1007/s11103-013-0078-4. Epub 2013 May 21. PubMed
Keratins control intercellular adhesion involving PKC-alpha-mediated desmoplakin phosphorylation. Kroger C, Loschke F, Schwarz N, Windoffer R, Leube RE, Magin TM. J Cell Biol. 2013 May 27;201(5):681-92. doi: 10.1083/jcb.201208162. Epub 2013 May 20. PubMed
Isolation, genetic manipulation, and transplantation of canine spermatogonial stem cells: progress toward transgenesis through the male germ-line. Harkey MA, Asano A, Zoulas ME, Torok-Storb B, Nagashima J, Travis A. Reproduction. 2013 Jun 14;146(1):75-90. doi: 10.1530/REP-13-0086. Print 2013 Jul. PubMed
Increased mutagenic joining of enzymatically-induced DNA double-strand breaks in high-charge and energy particle irradiated human cells. Li Z, Hudson FZ, Wang H, Wang Y, Bian Z, Murnane JP, Dynan WS. Radiat Res. 2013 Jul;180(1):17-24. doi: 10.1667/RR3332.1. Epub 2013 May 21. PubMed
Focal adhesion kinase is required for IGF-I-mediated growth of skeletal muscle cells via a TSC2/mTOR/S6K1-associated pathway. Crossland H, Kazi AA, Lang CH, Timmons JA, Pierre P, Wilkinson DJ, Smith K, Szewczyk NJ, Atherton PJ. Am J Physiol Endocrinol Metab. 2013 Jul 15;305(2):E183-93. doi: 10.1152/ajpendo.00541.2012. Epub 2013 May 21. PubMed
A robust strategy for negative selection of Cre-loxP recombination-based excision of transgenes in induced pluripotent stem cells. Chakraborty S, Christoforou N, Fattahi A, Herzog RW, Leong KW. PLoS One. 2013 May 22;8(5):e64342. doi: 10.1371/journal.pone.0064342. Print 2013. PubMed
Inhibiting Polo-like kinase 1 causes growth reduction and apoptosis in pediatric acute lymphoblastic leukemia cells. Hartsink-Segers SA, Exalto C, Allen M, Williamson D, Clifford SC, Horstmann M, Caron HN, Pieters R, Den Boer ML. Haematologica. 2013 Oct;98(10):1539-46. doi: 10.3324/haematol.2013.084434. Epub 2013 Jun 10. PubMed
Oxidative stress inhibits adhesion and transendothelial migration, and induces apoptosis and senescence of induced pluripotent stem cells. Wu Y, Zhang X, Kang X, Li N, Wang R, Hu T, Xiang M, Wang X, Yuan W, Chen A, Meng D, Chen S. Clin Exp Pharmacol Physiol. 2013 Sep;40(9):626-34. doi: 10.1111/1440-1681.12141. PubMed
Chemerin neutralization blocks hematopoietic stem cell osteoclastogenesis. Muruganandan S, Dranse HJ, Rourke JL, McMullen NM, Sinal CJ. Stem Cells. 2013 Oct;31(10):2172-82. doi: 10.1002/stem.1450. PubMed
The pluripotency factor nanog promotes breast cancer tumorigenesis and metastasis. Lu X, Mazur SJ, Lin T, Appella E, Xu Y. Oncogene. 2014 May 15;33(20):2655-64. doi: 10.1038/onc.2013.209. Epub 2013 Jun 17. PubMed
Acute-phase serum amyloid a in osteoarthritis: regulatory mechanism and proinflammatory properties. de Seny D, Cobraiville G, Charlier E, Neuville S, Esser N, Malaise D, Malaise O, Calvo FQ, Relic B, Malaise MG. PLoS One. 2013 Jun 12;8(6):e66769. doi: 10.1371/journal.pone.0066769. Print 2013. PubMed
A loss-of-function screen for phosphatases that regulate neurite outgrowth identifies PTPN12 as a negative regulator of TrkB tyrosine phosphorylation. Ambjorn M, Dubreuil V, Miozzo F, Nigon F, Moller B, Issazadeh-Navikas S, Berg J, Lees M, Sap J. PLoS One. 2013 Jun 13;8(6):e65371. doi: 10.1371/journal.pone.0065371. Print 2013. PubMed
Fibulin-2 is a driver of malignant progression in lung adenocarcinoma. Baird BN, Schliekelman MJ, Ahn YH, Chen Y, Roybal JD, Gill BJ, Mishra DK, Erez B, O'Reilly M, Yang Y, Patel M, Liu X, Thilaganathan N, Larina IV, Dickinson ME, West JL, Gibbons DL, Liu DD, Kim MP, Hicks JM, Wistuba II, Hanash SM, Kurie JM. PLoS One. 2013 Jun 10;8(6):e67054. doi: 10.1371/journal.pone.0067054. Print 2013. PubMed
Cyclin-dependent kinase 1-dependent phosphorylation of cAMP response element-binding protein decreases chromatin occupancy. Trinh AT, Kim SH, Chang HY, Mastrocola AS, Tibbetts RS. J Biol Chem. 2013 Aug 16;288(33):23765-75. doi: 10.1074/jbc.M113.464057. Epub 2013 Jun 27. PubMed
NGF upregulates the plasminogen activation inhibitor-1 in neurons via the calcineurin/NFAT pathway and the Down syndrome-related proteins DYRK1A and RCAN1 attenuate this effect. Stefos GC, Soppa U, Dierssen M, Becker W. PLoS One. 2013 Jun 25;8(6):e67470. doi: 10.1371/journal.pone.0067470. Print 2013. PubMed
Application of multiplexed kinase inhibitor beads to study kinome adaptations in drug-resistant leukemia. Cooper MJ, Cox NJ, Zimmerman EI, Dewar BJ, Duncan JS, Whittle MC, Nguyen TA, Jones LS, Ghose Roy S, Smalley DM, Kuan PF, Richards KL, Christopherson RI, Jin J, Frye SV, Johnson GL, Baldwin AS, Graves LM. PLoS One. 2013 Jun 24;8(6):e66755. doi: 10.1371/journal.pone.0066755. Print 2013. PubMed
The RNA-binding protein fused in sarcoma (FUS) functions downstream of poly(ADP-ribose) polymerase (PARP) in response to DNA damage. Mastrocola AS, Kim SH, Trinh AT, Rodenkirch LA, Tibbetts RS. J Biol Chem. 2013 Aug 23;288(34):24731-41. doi: 10.1074/jbc.M113.497974. Epub 2013 Jul 5. PubMed
Human innate immunity to Toxoplasma gondii is mediated by host caspase-1 and ASC and parasite GRA15. Gov L, Karimzadeh A, Ueno N, Lodoen MB. MBio. 2013 Jul 9;4(4). pii: e00255-13. doi: 10.1128/mBio.00255-13. PubMed
In vivo imaging of nitric oxide and hydrogen peroxide in cardiac myocytes. Sartoretto JL, Kalwa H, Romero N, Michel T. Methods Enzymol. 2013;528:61-78. doi: 10.1016/B978-0-12-405881-1.00004-5. PubMed
The DNA damage checkpoint precedes activation of ARF in response to escalating oncogenic stress during tumorigenesis. Evangelou K, Bartkova J, Kotsinas A, Pateras IS, Liontos M, Velimezi G, Kosar M, Liloglou T, Trougakos IP, Dyrskjot L, Andersen CL, Papaioannou M, Drosos Y, Papafotiou G, Hodny Z, Sosa-Pineda B, Wu XR, Klinakis A, Orntoft T, Lukas J, Bartek J, Gorgoulis VG. Cell Death Differ. 2013 Nov;20(11):1485-97. doi: 10.1038/cdd.2013.76. Epub 2013 Jul 12. PubMed
The Pitx2:miR-200c/141:noggin pathway regulates Bmp signaling and ameloblast differentiation. Cao H, Jheon A, Li X, Sun Z, Wang J, Florez S, Zhang Z, McManus MT, Klein OD, Amendt BA. Development. 2013 Aug;140(16):3348-59. doi: 10.1242/dev.089193. Epub 2013 Jul 17. PubMed
Transcriptional repression of Bim by a novel YY1-RelA complex is essential for the survival and growth of Multiple Myeloma. Potluri V, Noothi SK, Vallabhapurapu SD, Yoon SO, Driscoll JJ, Lawrie CH, Vallabhapurapu S. PLoS One. 2013 Jul 10;8(7):e66121. doi: 10.1371/journal.pone.0066121. Print 2013. PubMed
Neuropathic and inflammatory pain are modulated by tuberoinfundibular peptide of 39 residues. Dimitrov EL, Kuo J, Kohno K, Usdin TB. Proc Natl Acad Sci U S A. 2013 Aug 6;110(32):13156-61. doi: 10.1073/pnas.1306342110. Epub 2013 Jul 22. PubMed
GRP78-targeting subtilase cytotoxin sensitizes cancer cells to photodynamic therapy. Firczuk M, Gabrysiak M, Barankiewicz J, Domagala A, Nowis D, Kujawa M, Jankowska-Steifer E, Wachowska M, Glodkowska-Mrowka E, Korsak B, Winiarska M, Golab J. Cell Death Dis. 2013 Jul 25;4:e741. doi: 10.1038/cddis.2013.265. PubMed
Impairment of endothelial-myocardial interaction increases the susceptibility of cardiomyocytes to ischemia/reperfusion injury. Leucker TM, Ge ZD, Procknow J, Liu Y, Shi Y, Bienengraeber M, Warltier DC, Kersten JR. PLoS One. 2013 Jul 22;8(7):e70088. doi: 10.1371/journal.pone.0070088. Print 2013. PubMed
pRb controls estrogen receptor alpha protein stability and activity. Caligiuri I, Toffoli G, Giordano A, Rizzolio F. Oncotarget. 2013 Jun;4(6):875-83. PubMed
Length-dependent CTG.CAG triplet-repeat expansion in myotonic dystrophy patient-derived induced pluripotent stem cells. Du J, Campau E, Soragni E, Jespersen C, Gottesfeld JM. Hum Mol Genet. 2013 Dec 20;22(25):5276-87. doi: 10.1093/hmg/ddt386. Epub 2013 Aug 9. PubMed
Rab18 binds to hepatitis C virus NS5A and promotes interaction between sites of viral replication and lipid droplets. Salloum S, Wang H, Ferguson C, Parton RG, Tai AW. PLoS Pathog. 2013;9(8):e1003513. doi: 10.1371/journal.ppat.1003513. Epub 2013 Aug 1. PubMed
Knockdown of specific host factors protects against influenza virus-induced cell death. Tran AT, Rahim MN, Ranadheera C, Kroeker A, Cortens JP, Opanubi KJ, Wilkins JA, Coombs KM. Cell Death Dis. 2013 Aug 15;4:e769. doi: 10.1038/cddis.2013.296. PubMed
The zinc finger transcription factor ZXDC activates CCL2 gene expression by opposing BCL6-mediated repression. Ramsey JE, Fontes JD. Mol Immunol. 2013 Dec;56(4):768-80. doi: 10.1016/j.molimm.2013.07.001. Epub 2013 Aug 14. PubMed
Functions of huntingtin in germ layer specification and organogenesis. Nguyen GD, Molero AE, Gokhan S, Mehler MF. PLoS One. 2013 Aug 13;8(8):e72698. doi: 10.1371/journal.pone.0072698. eCollection 2013. PubMed
Mesenchymal stem cell survival in the infarcted heart is enhanced by lentivirus vector-mediated heat shock protein 27 expression. McGinley LM, McMahon J, Stocca A, Duffy A, Flynn A, O'Toole D, O'Brien T. Hum Gene Ther. 2013 Oct;24(10):840-51. doi: 10.1089/hum.2011.009. PubMed
PP2A-activating drugs selectively eradicate TKI-resistant chronic myeloid leukemic stem cells. Neviani P, Harb JG, Oaks JJ, Santhanam R, Walker CJ, Ellis JJ, Ferenchak G, Dorrance AM, Paisie CA, Eiring AM, Ma Y, Mao HC, Zhang B, Wunderlich M, May PC, Sun C, Saddoughi SA, Bielawski J, Blum W, Klisovic RB, Solt JA, Byrd JC, Volinia S, Cortes J, Huettner CS, Koschmieder S, Holyoake TL, Devine S, Caligiuri MA, Croce CM, Garzon R, Ogretmen B, Arlinghaus RB, Chen CS, Bittman R, Hokland P, Roy DC, Milojkovic D, Apperley J, Goldman JM, Reid A, Mulloy JC, Bhatia R, Marcucci G, Perrotti D. J Clin Invest. 2013 Oct;123(10):4144-57. doi: 10.1172/JCI68951. Epub 2013 Sep 3. PubMed
Unsaturated fatty acids prevent activation of NLRP3 inflammasome in human monocytes/macrophages. L'homme L, Esser N, Riva L, Scheen A, Paquot N, Piette J, Legrand-Poels S. J Lipid Res. 2013 Nov;54(11):2998-3008. doi: 10.1194/jlr.M037861. Epub 2013 Sep 3. PubMed
Kinetics of acrylodan-labelled cAMP-dependent protein kinase catalytic subunit denaturation. Kivi R, Loog M, Jemth P, Jarv J. Protein J. 2013 Oct;32(7):519-25. doi: 10.1007/s10930-013-9511-4. PubMed
Bone marrow-derived mesenchymal stem cells enhance angiogenesis via their alpha6beta1 integrin receptor. Carrion B, Kong YP, Kaigler D, Putnam AJ. Exp Cell Res. 2013 Nov 15;319(19):2964-76. doi: 10.1016/j.yexcr.2013.09.007. Epub 2013 Sep 19. PubMed
FMRP regulates actin filament organization via the armadillo protein p0071. Nolze A, Schneider J, Keil R, Lederer M, Huttelmaier S, Kessels MM, Qualmann B, Hatzfeld M. RNA. 2013 Nov;19(11):1483-96. doi: 10.1261/rna.037945.112. Epub 2013 Sep 23. PubMed
Improved lentiviral transduction of ALS motoneurons in vivo via dual targeting. O'Leary VB, Ovsepian SV, Bodeker M, Dolly JO. Mol Pharm. 2013 Nov 4;10(11):4195-206. doi: 10.1021/mp400247t. Epub 2013 Oct 11. PubMed
Secreted Frizzled-related protein potentiation versus inhibition of Wnt3a/beta-catenin signaling. Xavier CP, Melikova M, Chuman Y, Uren A, Baljinnyam B, Rubin JS. Cell Signal. 2014 Jan;26(1):94-101. doi: 10.1016/j.cellsig.2013.09.016. Epub 2013 Sep 28. PubMed
Thalamic neuropeptide mediating the effects of nursing on lactation and maternal motivation. Cservenak M, Szabo ER, Bodnar I, Leko A, Palkovits M, Nagy GM, Usdin TB, Dobolyi A. Psychoneuroendocrinology. 2013 Dec;38(12):3070-84. doi: 10.1016/j.psyneuen.2013.09.004. Epub 2013 Sep 14. PubMed
Human F1F0 ATP synthase, mitochondrial ultrastructure and OXPHOS impairment: a (super-)complex matter? Habersetzer J, Larrieu I, Priault M, Salin B, Rossignol R, Brethes D, Paumard P. PLoS One. 2013 Oct 2;8(10):e75429. doi: 10.1371/journal.pone.0075429. eCollection 2013. PubMed
Role of JunB in adenosine A2B receptor-mediated vascular endothelial growth factor production. Ryzhov S, Biktasova A, Goldstein AE, Zhang Q, Biaggioni I, Dikov MM, Feoktistov I. Mol Pharmacol. 2014 Jan;85(1):62-73. doi: 10.1124/mol.113.088567. Epub 2013 Oct 17. PubMed
Doxycycline-regulated GDNF expression promotes axonal regeneration and functional recovery in transected peripheral nerve. Shakhbazau A, Mohanty C, Shcharbin D, Bryszewska M, Caminade AM, Majoral JP, Alant J, Midha R. J Control Release. 2013 Dec 28;172(3):841-51. doi: 10.1016/j.jconrel.2013.10.004. Epub 2013 Oct 17. PubMed
CD36-specific antibodies block release of HIV-1 from infected primary macrophages and its transmission to T cells. Berre S, Gaudin R, Cunha de Alencar B, Desdouits M, Chabaud M, Naffakh N, Rabaza-Gairi M, Gobert FX, Jouve M, Benaroch P. J Exp Med. 2013 Nov 18;210(12):2523-38. doi: 10.1084/jem.20130566. Epub 2013 Oct 21. PubMed
Depletion of a putatively druggable class of phosphatidylinositol kinases inhibits growth of p53-null tumors. Emerling BM, Hurov JB, Poulogiannis G, Tsukazawa KS, Choo-Wing R, Wulf GM, Bell EL, Shim HS, Lamia KA, Rameh LE, Bellinger G, Sasaki AT, Asara JM, Yuan X, Bullock A, Denicola GM, Song J, Brown V, Signoretti S, Cantley LC. Cell. 2013 Nov 7;155(4):844-57. doi: 10.1016/j.cell.2013.09.057. PubMed
Establishing isogenic inducible cell lines using founder reporter lines and recombinase-mediated cassette exchange. Guan B, Magomi T, Wang TL, Shih IeM. Biotechniques. 2013 Nov;55(5):233-42. doi: 10.2144/000114098. PubMed
In vitro expansion and genetic modification of gastrointestinal stem cells in spheroid culture. Miyoshi H, Stappenbeck TS. Nat Protoc. 2013 Dec;8(12):2471-82. doi: 10.1038/nprot.2013.153. Epub 2013 Nov 14. PubMed
Adherens junction formation inhibits lentivirus entry and gene transfer. Padmashali R, You H, Karnik N, Lei P, Andreadis ST. PLoS One. 2013 Nov 13;8(11):e79265. doi: 10.1371/journal.pone.0079265. eCollection 2013. PubMed
Increased expression of S100A6 promotes cell proliferation and migration in human hepatocellular carcinoma. Li Z, Tang M, Ling B, Liu S, Zheng Y, Nie C, Yuan Z, Zhou L, Guo G, Tong A, Wei Y. J Mol Med (Berl). 2014 Mar;92(3):291-303. doi: 10.1007/s00109-013-1104-3. Epub 2013 Nov 27. PubMed
Reduced expression of the chromatin remodeling gene ARID1A enhances gastric cancer cell migration and invasion via downregulation of E-cadherin transcription. Yan HB, Wang XF, Zhang Q, Tang ZQ, Jiang YH, Fan HZ, Sun YH, Yang PY, Liu F. Carcinogenesis. 2014 Apr;35(4):867-76. doi: 10.1093/carcin/bgt398. Epub 2013 Nov 30. PubMed
A potassium leak channel silences hyperactive neurons and ameliorates status epilepticus. Dey D, Eckle VS, Vitko I, Sullivan KA, Lasiecka ZM, Winckler B, Stornetta RL, Williamson JM, Kapur J, Perez-Reyes E. Epilepsia. 2014 Feb;55(2):203-13. doi: 10.1111/epi.12472. Epub 2013 Dec 2. PubMed
Visualizing of signaling proteins on endosomes utilizing knockdown and reconstitution approach. Jeoung M, Galperin E. Methods Enzymol. 2014;534:47-63. doi: 10.1016/B978-0-12-397926-1.00003-2. PubMed
Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging. Gomes AP, Price NL, Ling AJ, Moslehi JJ, Montgomery MK, Rajman L, White JP, Teodoro JS, Wrann CD, Hubbard BP, Mercken EM, Palmeira CM, de Cabo R, Rolo AP, Turner N, Bell EL, Sinclair DA. Cell. 2013 Dec 19;155(7):1624-38. doi: 10.1016/j.cell.2013.11.037. PubMed
Pore-exposed tyrosine residues of P-glycoprotein are important hydrogen-bonding partners for drugs. Donmez Cakil Y, Khunweeraphong N, Parveen Z, Schmid D, Artaker M, Ecker GF, Sitte HH, Pusch O, Stockner T, Chiba P. Mol Pharmacol. 2014 Mar;85(3):420-8. doi: 10.1124/mol.113.088526. Epub 2013 Dec 23. PubMed
BET bromodomain inhibition triggers apoptosis of NF1-associated malignant peripheral nerve sheath tumors through Bim induction. Patel AJ, Liao CP, Chen Z, Liu C, Wang Y, Le LQ. Cell Rep. 2014 Jan 16;6(1):81-92. doi: 10.1016/j.celrep.2013.12.001. Epub 2013 Dec 27. PubMed
Tight control of hypoxia-inducible factor-alpha transient dynamics is essential for cell survival in hypoxia. Bagnall J, Leedale J, Taylor SE, Spiller DG, White MR, Sharkey KJ, Bearon RN, See V. J Biol Chem. 2014 Feb 28;289(9):5549-64. doi: 10.1074/jbc.M113.500405. Epub 2014 Jan 6. PubMed

Associated Plasmids

Inhibition of stearoyl-coA desaturase selectively eliminates tumorigenic Nanog-positive cells: improving the safety of iPS cell transplantation to myocardium. Zhang L, Pan Y, Qin G, Chen L, Chatterjee TK, Weintraub NL, Tang Y. Cell Cycle. 2014;13(5):762-71. doi: 10.4161/cc.27677. Epub 2014 Jan 6. PubMed
microRNAs miR-27a and miR-27b directly regulate liver dihydropyrimidine dehydrogenase expression through two conserved binding sites. Offer SM, Butterfield GL, Jerde CR, Fossum CC, Wegner NJ, Diasio RB. Mol Cancer Ther. 2014 Mar;13(3):742-51. doi: 10.1158/1535-7163.MCT-13-0878. Epub 2014 Jan 8. PubMed
Dystrophin-deficient cardiomyocytes derived from human urine: new biologic reagents for drug discovery. Guan X, Mack DL, Moreno CM, Strande JL, Mathieu J, Shi Y, Markert CD, Wang Z, Liu G, Lawlor MW, Moorefield EC, Jones TN, Fugate JA, Furth ME, Murry CE, Ruohola-Baker H, Zhang Y, Santana LF, Childers MK. Stem Cell Res. 2014 Mar;12(2):467-80. doi: 10.1016/j.scr.2013.12.004. Epub 2013 Dec 23. PubMed
Gene delivery in malignant B cells using the combination of lentiviruses conjugated to anti-transferrin receptor antibodies and an immunoglobulin promoter. Leoh LS, Morizono K, Kershaw KM, Chen IS, Penichet ML, Daniels-Wells TR. J Gene Med. 2014 Jan-Feb;16(1-2):11-27. doi: 10.1002/jgm.2754. PubMed
CCN2 suppresses catabolic effects of interleukin-1beta through alpha5beta1 and alphaVbeta3 integrins in nucleus pulposus cells: implications in intervertebral disc degeneration. Tran CM, Schoepflin ZR, Markova DZ, Kepler CK, Anderson DG, Shapiro IM, Risbud MV. J Biol Chem. 2014 Mar 14;289(11):7374-87. doi: 10.1074/jbc.M113.526111. Epub 2014 Jan 24. PubMed
Oxysterol-binding protein is a phosphatidylinositol 4-kinase effector required for HCV replication membrane integrity and cholesterol trafficking. Wang H, Perry JW, Lauring AS, Neddermann P, De Francesco R, Tai AW. Gastroenterology. 2014 May;146(5):1373-85.e1-11. doi: 10.1053/j.gastro.2014.02.002. Epub 2014 Feb 8. PubMed
Importance of CD44 in the proliferation and mineralization of periodontal ligament cells. Yeh Y, Yang Y, Yuan K. J Periodontal Res. 2014 Dec;49(6):827-35. doi: 10.1111/jre.12170. Epub 2014 Feb 12. PubMed
Epstein-Barr virus utilizes Ikaros in regulating its latent-lytic switch in B cells. Iempridee T, Reusch JA, Riching A, Johannsen EC, Dovat S, Kenney SC, Mertz JE. J Virol. 2014 May;88(9):4811-27. doi: 10.1128/JVI.03706-13. Epub 2014 Feb 12. PubMed
Rapid cellular phenotyping of human pluripotent stem cell-derived cardiomyocytes using a genetically encoded fluorescent voltage sensor. Leyton-Mange JS, Mills RW, Macri VS, Jang MY, Butte FN, Ellinor PT, Milan DJ. Stem Cell Reports. 2014 Feb 6;2(2):163-70. doi: 10.1016/j.stemcr.2014.01.003. eCollection 2014 Feb 11. PubMed
The PYRIN domain-only protein POP3 inhibits ALR inflammasomes and regulates responses to infection with DNA viruses. Khare S, Ratsimandresy RA, de Almeida L, Cuda CM, Rellick SL, Misharin AV, Wallin MC, Gangopadhyay A, Forte E, Gottwein E, Perlman H, Reed JC, Greaves DR, Dorfleutner A, Stehlik C. Nat Immunol. 2014 Apr;15(4):343-53. doi: 10.1038/ni.2829. Epub 2014 Feb 16. PubMed

Associated Plasmids

deltaNp63 has a role in maintaining epithelial integrity in airway epithelium. Arason AJ, Jonsdottir HR, Halldorsson S, Benediktsdottir BE, Bergthorsson JT, Ingthorsson S, Baldursson O, Sinha S, Gudjonsson T, Magnusson MK. PLoS One. 2014 Feb 12;9(2):e88683. doi: 10.1371/journal.pone.0088683. eCollection 2014. PubMed
Cell adhesion molecules in metastatic neuroblastoma models. Schwankhaus N, Gathmann C, Wicklein D, Riecken K, Schumacher U, Valentiner U. Clin Exp Metastasis. 2014 Feb 19. PubMed
Lentiviral vectors encoding zinc-finger nucleases specific for the model target locus HPRT1. Pelascini LP, Goncalves MA. Methods Mol Biol. 2014;1114:181-99. doi: 10.1007/978-1-62703-761-7_12. PubMed
Inhibition of mTORC1 induces loss of E-cadherin through AKT/GSK-3beta signaling-mediated upregulation of E-cadherin repressor complexes in non-small cell lung cancer cells. Kim EY, Kim A, Kim SK, Kim HJ, Chang J, Ahn CM, Chang YS. Respir Res. 2014 Feb 26;15:26. doi: 10.1186/1465-9921-15-26. PubMed
The Vac14-interaction network is linked to regulators of the endolysosomal and autophagic pathway. Schulze U, Vollenbroker B, Braun DA, Van Le T, Granado D, Kremerskothen J, Franzel B, Klosowski R, Barth J, Fufezan C, Wolters DA, Pavenstadt H, Weide T. Mol Cell Proteomics. 2014 Jun;13(6):1397-411. doi: 10.1074/mcp.M113.034108. Epub 2014 Feb 27. PubMed
Resistance to mTOR kinase inhibitors in lymphoma cells lacking 4EBP1. Mallya S, Fitch BA, Lee JS, So L, Janes MR, Fruman DA. PLoS One. 2014 Feb 21;9(2):e88865. doi: 10.1371/journal.pone.0088865. eCollection 2014. PubMed
Inhibition of TGFbeta signaling increases direct conversion of fibroblasts to induced cardiomyocytes. Ifkovits JL, Addis RC, Epstein JA, Gearhart JD. PLoS One. 2014 Feb 26;9(2):e89678. doi: 10.1371/journal.pone.0089678. eCollection 2014. PubMed
Cocaine disrupts histamine H3 receptor modulation of dopamine D1 receptor signaling: sigma1-D1-H3 receptor complexes as key targets for reducing cocaine's effects. Moreno E, Moreno-Delgado D, Navarro G, Hoffmann HM, Fuentes S, Rosell-Vilar S, Gasperini P, Rodriguez-Ruiz M, Medrano M, Mallol J, Cortes A, Casado V, Lluis C, Ferre S, Ortiz J, Canela E, McCormick PJ. J Neurosci. 2014 Mar 5;34(10):3545-58. doi: 10.1523/JNEUROSCI.4147-13.2014. PubMed
Production, purification and titration of a lentivirus-based vector for gene delivery purposes. Nasri M, Karimi A, Allahbakhshian Farsani M. Cytotechnology. 2014 Dec;66(6):1031-8. doi: 10.1007/s10616-013-9652-5. Epub 2014 Mar 6. PubMed
hCLE/C14orf166 associates with DDX1-HSPC117-FAM98B in a novel transcription-dependent shuttling RNA-transporting complex. Perez-Gonzalez A, Pazo A, Navajas R, Ciordia S, Rodriguez-Frandsen A, Nieto A. PLoS One. 2014 Mar 7;9(3):e90957. doi: 10.1371/journal.pone.0090957. eCollection 2014. PubMed
SAA1 polymorphisms are associated with variation in antiangiogenic and tumor-suppressive activities in nasopharyngeal carcinoma. Lung HL, Man OY, Yeung MC, Ko JM, Cheung AK, Law EW, Yu Z, Shuen WH, Tung E, Chan SH, Bangarusamy DK, Cheng Y, Yang X, Kan R, Phoon Y, Chan KC, Chua D, Kwong DL, Lee AW, Ji MF, Lung ML. Oncogene. 2015 Feb 12;34(7):878-89. doi: 10.1038/onc.2014.12. Epub 2014 Mar 10. PubMed
GP73 is upregulated by hepatitis C virus (HCV) infection and enhances HCV secretion. Hu L, Yao W, Wang F, Rong X, Peng T. PLoS One. 2014 Mar 7;9(3):e90553. doi: 10.1371/journal.pone.0090553. eCollection 2014. PubMed
Sphingosine Phosphate Lyase Regulates Murine Embryonic Stem Cell Proliferation and Pluripotency through an S1P/STAT3 Signaling Pathway. Smith GS, Kumar A, Saba JD. Biomolecules. 2013 Jun 24;3(3):351-368. PubMed
EMP1, a novel poor prognostic factor in pediatric leukemia regulates prednisolone resistance, cell proliferation, migration and adhesion. Aries IM, Jerchel IS, van den Dungen RE, van den Berk LC, Boer JM, Horstmann MA, Escherich G, Pieters R, den Boer ML. Leukemia. 2014 Sep;28(9):1828-37. doi: 10.1038/leu.2014.80. Epub 2014 Feb 20. PubMed
A protective antigen mutation increases the pH threshold of anthrax toxin receptor 2-mediated pore formation. Dennis MK, Mogridge J. Biochemistry. 2014 Apr 8;53(13):2166-71. doi: 10.1021/bi5000756. Epub 2014 Mar 25. PubMed
MiR-92a regulates viability and angiogenesis of endothelial cells under oxidative stress. Zhang L, Zhou M, Qin G, Weintraub NL, Tang Y. Biochem Biophys Res Commun. 2014 Apr 18;446(4):952-8. doi: 10.1016/j.bbrc.2014.03.035. Epub 2014 Mar 17. PubMed
RPTPalpha controls epithelial adherens junctions, linking E-cadherin engagement to c-Src-mediated phosphorylation of cortactin. Truffi M, Dubreuil V, Liang X, Vacaresse N, Nigon F, Han SP, Yap AS, Gomez GA, Sap J. J Cell Sci. 2014 Jun 1;127(Pt 11):2420-32. doi: 10.1242/jcs.134379. Epub 2014 Mar 20. PubMed

Associated Plasmids

Expressed glycosylphosphatidylinositol-anchored horseradish peroxidase identifies co-clustering molecules in individual lipid raft domains. Miyagawa-Yamaguchi A, Kotani N, Honke K. PLoS One. 2014 Mar 26;9(3):e93054. doi: 10.1371/journal.pone.0093054. eCollection 2014. PubMed
Evolutionary and molecular facts link the WWC protein family to Hippo signaling. Wennmann DO, Schmitz J, Wehr MC, Krahn MP, Koschmal N, Gromnitza S, Schulze U, Weide T, Chekuri A, Skryabin BV, Gerke V, Pavenstadt H, Duning K, Kremerskothen J. Mol Biol Evol. 2014 Jul;31(7):1710-23. doi: 10.1093/molbev/msu115. Epub 2014 Mar 27. PubMed
Myostatin knockdown and its effect on myogenic gene expression program in stably transfected goat myoblasts. Patel AK, Tripathi AK, Patel UA, Shah RK, Joshi CG. In Vitro Cell Dev Biol Anim. 2014 Aug;50(7):587-96. doi: 10.1007/s11626-014-9743-4. Epub 2014 Mar 28. PubMed
Activation of neural cell fate programs toward direct conversion of adult human fibroblasts into tri-potent neural progenitors using OCT-4. Mitchell RR, Szabo E, Benoit YD, Case DT, Mechael R, Alamilla J, Lee JH, Fiebig-Comyn A, Gillespie DC, Bhatia M. Stem Cells Dev. 2014 Aug 15;23(16):1937-46. doi: 10.1089/scd.2014.0023. Epub 2014 May 13. PubMed
Generation and characterization of induced pluripotent stem cells from Aid-deficient mice. Shimamoto R, Amano N, Ichisaka T, Watanabe A, Yamanaka S, Okita K. PLoS One. 2014 Apr 9;9(4):e94735. doi: 10.1371/journal.pone.0094735. eCollection 2014. PubMed
CDK2-dependent phosphorylation of Suv39H1 is involved in control of heterochromatin replication during cell cycle progression. Park SH, Yu SE, Chai YG, Jang YK. Nucleic Acids Res. 2014 Jun;42(10):6196-207. doi: 10.1093/nar/gku263. Epub 2014 Apr 11. PubMed
Evaluation of apoptosis induction by concomitant inhibition of MEK, mTOR, and Bcl-2 in human acute myelogenous leukemia cells. Zhang W, Ruvolo VR, Gao C, Zhou L, Bornmann W, Tsao T, Schober WD, Smith P, Guichard S, Konopleva M, Andreeff M. Mol Cancer Ther. 2014 Jul;13(7):1848-59. doi: 10.1158/1535-7163.MCT-13-0576. Epub 2014 Apr 16. PubMed
Pancreatic beta-cell failure mediated by mTORC1 hyperactivity and autophagic impairment. Bartolome A, Kimura-Koyanagi M, Asahara S, Guillen C, Inoue H, Teruyama K, Shimizu S, Kanno A, Garcia-Aguilar A, Koike M, Uchiyama Y, Benito M, Noda T, Kido Y. Diabetes. 2014 Sep;63(9):2996-3008. doi: 10.2337/db13-0970. Epub 2014 Apr 16. PubMed
"Triplet" polycistronic vectors encoding Gata4, Mef2c, and Tbx5 enhances postinfarct ventricular functional improvement compared with singlet vectors. Mathison M, Singh VP, Gersch RP, Ramirez MO, Cooney A, Kaminsky SM, Chiuchiolo MJ, Nasser A, Yang J, Crystal RG, Rosengart TK. J Thorac Cardiovasc Surg. 2014 Oct;148(4):1656-1664.e2. doi: 10.1016/j.jtcvs.2014.03.033. Epub 2014 Mar 27. PubMed
Tissue-engineered cartilage with inducible and tunable immunomodulatory properties. Glass KA, Link JM, Brunger JM, Moutos FT, Gersbach CA, Guilak F. Biomaterials. 2014 Jul;35(22):5921-31. doi: 10.1016/j.biomaterials.2014.03.073. Epub 2014 Apr 22. PubMed
Murine norovirus: propagation, quantification, and genetic manipulation. Hwang S, Alhatlani B, Arias A, Caddy SL, Christodoulou C, Cunha JB, Emmott E, Gonzalez-Hernandez M, Kolawole A, Lu J, Rippinger C, Sorgeloos F, Thorne L, Vashist S, Goodfellow I, Wobus CE. Curr Protoc Microbiol. 2014 May 1;33:15K.2.1-61. doi: 10.1002/9780471729259.mc15k02s33. PubMed
Impact of an altered PROX1 expression on clinicopathology, prognosis and progression in renal cell carcinoma. Lv T, Liu Y, Zhang J, Xu L, Zhu Y, Yin H, An H, Lin Z, Xie Y, Chen L. PLoS One. 2014 May 5;9(5):e95996. doi: 10.1371/journal.pone.0095996. eCollection 2014. PubMed
Polymerase I and transcript release factor (PTRF) regulates adipocyte differentiation and determines adipose tissue expandability. Perez-Diaz S, Johnson LA, DeKroon RM, Moreno-Navarrete JM, Alzate O, Fernandez-Real JM, Maeda N, Arbones-Mainar JM. FASEB J. 2014 Aug;28(8):3769-79. doi: 10.1096/fj.14-251165. Epub 2014 May 8. PubMed
New role for EMD (emerin), a key inner nuclear membrane protein, as an enhancer of autophagosome formation in the C16-ceramide autophagy pathway. Deroyer C, Renert AF, Merville MP, Fillet M. Autophagy. 2014 Jul;10(7):1229-40. doi: 10.4161/auto.28777. Epub 2014 May 7. PubMed
Long intergenic non-coding RNA HOTAIRM1 regulates cell cycle progression during myeloid maturation in NB4 human promyelocytic leukemia cells. Zhang X, Weissman SM, Newburger PE. RNA Biol. 2014;11(6):777-87. Epub 2014 Apr 24. PubMed
SIRT2 induces the checkpoint kinase BubR1 to increase lifespan. North BJ, Rosenberg MA, Jeganathan KB, Hafner AV, Michan S, Dai J, Baker DJ, Cen Y, Wu LE, Sauve AA, van Deursen JM, Rosenzweig A, Sinclair DA. EMBO J. 2014 Jul 1;33(13):1438-53. doi: 10.15252/embj.201386907. Epub 2014 May 12. PubMed
Quantitative proteomic analysis of host-virus interactions reveals a role for Golgi brefeldin A resistance factor 1 (GBF1) in dengue infection. Carpp LN, Rogers RS, Moritz RL, Aitchison JD. Mol Cell Proteomics. 2014 Nov;13(11):2836-54. doi: 10.1074/mcp.M114.038984. Epub 2014 May 22. PubMed
MST4 promotes hepatocellular carcinoma epithelial-mesenchymal transition and metastasis via activation of the p-ERK pathway. Lin ZH, Wang L, Zhang JB, Liu Y, Li XQ, Guo L, Zhang B, Zhu WW, Ye QH. Int J Oncol. 2014 Aug;45(2):629-40. doi: 10.3892/ijo.2014.2455. Epub 2014 May 22. PubMed
FIH-1-Mint3 axis does not control HIF-1 transcriptional activity in nucleus pulposus cells. Hirose Y, Johnson ZI, Schoepflin ZR, Markova DZ, Chiba K, Toyama Y, Shapiro IM, Risbud MV. J Biol Chem. 2014 Jul 25;289(30):20594-605. PubMed
Monitoring the dynamics of clonal tumour evolution in vivo using secreted luciferases. Charles JP, Fuchs J, Hefter M, Vischedyk JB, Kleint M, Vogiatzi F, Schafer JA, Nist A, Timofeev O, Wanzel M, Stiewe T. Nat Commun. 2014 Jun 3;5:3981. doi: 10.1038/ncomms4981. PubMed
Nrf2, a regulator of the proteasome, controls self-renewal and pluripotency in human embryonic stem cells. Jang J, Wang Y, Kim HS, Lalli MA, Kosik KS. Stem Cells. 2014 Oct;32(10):2616-25. doi: 10.1002/stem.1764. PubMed
Autophagy promotes resistance to photodynamic therapy-induced apoptosis selectively in colorectal cancer stem-like cells. Wei MF, Chen MW, Chen KC, Lou PJ, Lin SY, Hung SC, Hsiao M, Yao CJ, Shieh MJ. Autophagy. 2014 Jul;10(7):1179-92. doi: 10.4161/auto.28679. Epub 2014 Apr 29. PubMed
Molecular neuroimaging of post-injury plasticity. Jouroukhin Y, Nonyane BA, Gilad AA, Pelled G. J Mol Neurosci. 2014 Dec;54(4):630-8. doi: 10.1007/s12031-014-0347-y. Epub 2014 Jun 10. PubMed
Inhibition of glutathione peroxidase mediates the collateral sensitivity of multidrug-resistant cells to tiopronin. Hall MD, Marshall TS, Kwit AD, Miller Jenkins LM, Dulcey AE, Madigan JP, Pluchino KM, Goldsborough AS, Brimacombe KR, Griffiths GL, Gottesman MM. J Biol Chem. 2014 Aug 1;289(31):21473-89. doi: 10.1074/jbc.M114.581702. Epub 2014 Jun 14. PubMed
17beta-estradiol regulates giant vesicle formation via estrogen receptor-alpha in human breast cancer cells. Wright PK, Jones SB, Ardern N, Ward R, Clarke RB, Sotgia F, Lisanti MP, Landberg G, Lamb R. Oncotarget. 2014 May 30;5(10):3055-65. PubMed
The prolyl peptidases PRCP/PREP regulate IRS-1 stability critical for rapamycin-induced feedback activation of PI3K and AKT. Duan L, Ying G, Danzer B, Perez RE, Shariat-Madar Z, Levenson VV, Maki CG. J Biol Chem. 2014 Aug 1;289(31):21694-705. doi: 10.1074/jbc.M114.550038. Epub 2014 Jun 16. PubMed
IL-17 and GM-CSF expression are antagonistically regulated by human T helper cells. Noster R, Riedel R, Mashreghi MF, Radbruch H, Harms L, Haftmann C, Chang HD, Radbruch A, Zielinski CE. Sci Transl Med. 2014 Jun 18;6(241):241ra80. doi: 10.1126/scitranslmed.3008706. PubMed
Generation of mouse models of myeloid malignancy with combinatorial genetic lesions using CRISPR-Cas9 genome editing. Heckl D, Kowalczyk MS, Yudovich D, Belizaire R, Puram RV, McConkey ME, Thielke A, Aster JC, Regev A, Ebert BL. Nat Biotechnol. 2014 Jun 22. doi: 10.1038/nbt.2951. PubMed

Associated Plasmids

Assessing the efficacy of nano- and micro-sized magnetic particles as contrast agents for MRI cell tracking. Taylor A, Herrmann A, Moss D, See V, Davies K, Williams SR, Murray P. PLoS One. 2014 Jun 24;9(6):e100259. doi: 10.1371/journal.pone.0100259. eCollection 2014. PubMed
Quantitative phosphoproteomics reveals novel phosphorylation events in insulin signaling regulated by protein phosphatase 1 regulatory subunit 12A. Zhang X, Ma D, Caruso M, Lewis M, Qi Y, Yi Z. J Proteomics. 2014 Sep 23;109:63-75. doi: 10.1016/j.jprot.2014.06.010. Epub 2014 Jun 25. PubMed
PKCzeta and PKMzeta are overexpressed in TCF3-rearranged paediatric acute lymphoblastic leukaemia and are associated with increased thiopurine sensitivity. Hartsink-Segers SA, Beaudoin JJ, Luijendijk MW, Exalto C, Pieters R, Den Boer ML. Leukemia. 2015 Feb;29(2):304-11. doi: 10.1038/leu.2014.210. Epub 2014 Jul 3. PubMed
ERbeta- and prostaglandin E2-regulated pathways integrate cell proliferation via Ras-like and estrogen-regulated growth inhibitor in endometriosis. Monsivais D, Dyson MT, Yin P, Coon JS, Navarro A, Feng G, Malpani SS, Ono M, Ercan CM, Wei JJ, Pavone ME, Su E, Bulun SE. Mol Endocrinol. 2014 Aug;28(8):1304-15. doi: 10.1210/me.2013-1421. Epub 2014 Jul 3. PubMed
Sirtuin1 (Sirt1) promotes cortical bone formation by preventing beta-catenin sequestration by FoxO transcription factors in osteoblast progenitors. Iyer S, Han L, Bartell SM, Kim HN, Gubrij I, de Cabo R, O'Brien CA, Manolagas SC, Almeida M. J Biol Chem. 2014 Aug 29;289(35):24069-78. doi: 10.1074/jbc.M114.561803. Epub 2014 Jul 7. PubMed
Par3-mInsc and Galphai3 cooperate to promote oriented epidermal cell divisions through LGN. Williams SE, Ratliff LA, Postiglione MP, Knoblich JA, Fuchs E. Nat Cell Biol. 2014 Aug;16(8):758-69. doi: 10.1038/ncb3001. Epub 2014 Jul 13. PubMed
Development of a lentivirus vector-based assay for non-destructive monitoring of cell fusion activity. Neshati Z, Liu J, Zhou G, Schalij MJ, de Vries AA. PLoS One. 2014 Jul 16;9(7):e102433. doi: 10.1371/journal.pone.0102433. eCollection 2014. PubMed
CREB SUMOylation by the E3 ligase PIAS1 enhances spatial memory. Chen YC, Hsu WL, Ma YL, Tai DJ, Lee EH. J Neurosci. 2014 Jul 16;34(29):9574-89. doi: 10.1523/JNEUROSCI.4302-13.2014. PubMed
Differential requirements of arrestin-3 and clathrin for ligand-dependent and -independent internalization of human G protein-coupled receptor 40. Qian J, Wu C, Chen X, Li X, Ying G, Jin L, Ma Q, Li G, Shi Y, Zhang G, Zhou N. Cell Signal. 2014 Nov;26(11):2412-23. doi: 10.1016/j.cellsig.2014.07.019. Epub 2014 Jul 16. PubMed
Oncogenic role of Merlin/NF2 in glioblastoma. Guerrero PA, Yin W, Camacho L, Marchetti D. Oncogene. 2015 May 14;34(20):2621-30. doi: 10.1038/onc.2014.185. Epub 2014 Jul 21. PubMed
Tumor necrosis factor-alpha- and interleukin-1beta-dependent matrix metalloproteinase-3 expression in nucleus pulposus cells requires cooperative signaling via syndecan 4 and mitogen-activated protein kinase-NF-kappaB axis: implications in inflammatory disc disease. Wang X, Wang H, Yang H, Li J, Cai Q, Shapiro IM, Risbud MV. Am J Pathol. 2014 Sep;184(9):2560-72. doi: 10.1016/j.ajpath.2014.06.006. Epub 2014 Jul 22. PubMed
A home-brew real-time PCR assay for reliable detection and quantification of mature miR-122. Naderi M, Abdul Tehrani H, Soleimani M, Shabani I, Hashemi SM. Appl Immunohistochem Mol Morphol. 2015 Sep;23(8):601-6. doi: 10.1097/PAI.0000000000000125. PubMed
Analysis of transcription factor network underlying 3T3-L1 adipocyte differentiation. Choi K, Ghaddar B, Moya C, Shi H, Sridharan GV, Lee K, Jayaraman A. PLoS One. 2014 Jul 30;9(7):e100177. doi: 10.1371/journal.pone.0100177. eCollection 2014. PubMed
SOX2 is a cancer-specific regulator of tumour initiating potential in cutaneous squamous cell carcinoma. Siegle JM, Basin A, Sastre-Perona A, Yonekubo Y, Brown J, Sennett R, Rendl M, Tsirigos A, Carucci JA, Schober M. Nat Commun. 2014 Jul 31;5:4511. doi: 10.1038/ncomms5511. PubMed
An essential role for the K+-dependent Na+/Ca2+-exchanger, NCKX4, in melanocortin-4-receptor-dependent satiety. Li XF, Lytton J. J Biol Chem. 2014 Sep 12;289(37):25445-59. doi: 10.1074/jbc.M114.564450. Epub 2014 Aug 5. PubMed
Porcine reproductive and respiratory syndrome virus counteracts the porcine intrinsic virus restriction factors-IFITM1 and Tetherin in MARC-145 cells. Wang X, Li C, Zhou L, Zhang N, Wang X, Ge X, Guo X, Yang H. Virus Res. 2014 Oct 13;191:92-100. doi: 10.1016/j.virusres.2014.07.025. Epub 2014 Aug 4. PubMed
An acetate switch regulates stress erythropoiesis. Xu M, Nagati JS, Xie J, Li J, Walters H, Moon YA, Gerard RD, Huang CL, Comerford SA, Hammer RE, Horton JD, Chen R, Garcia JA. Nat Med. 2014 Sep;20(9):1018-26. doi: 10.1038/nm.3587. Epub 2014 Aug 10. PubMed
Myeloid-specific disruption of tyrosine phosphatase Shp2 promotes alternative activation of macrophages and predisposes mice to pulmonary fibrosis. Tao B, Jin W, Xu J, Liang Z, Yao J, Zhang Y, Wang K, Cheng H, Zhang X, Ke Y. J Immunol. 2014 Sep 15;193(6):2801-11. doi: 10.4049/jimmunol.1303463. Epub 2014 Aug 15. PubMed
PGE2-induced colon cancer growth is mediated by mTORC1. Dufour M, Faes S, Dormond-Meuwly A, Demartines N, Dormond O. Biochem Biophys Res Commun. 2014 Sep 5;451(4):587-91. doi: 10.1016/j.bbrc.2014.08.032. Epub 2014 Aug 13. PubMed
The transcription factor FOXA2 suppresses gastric tumorigenesis in vitro and in vivo. Zhu CP, Wang J, Shi B, Hu PF, Ning BF, Zhang Q, Chen F, Chen WS, Zhang X, Xie WF. Dig Dis Sci. 2015 Jan;60(1):109-17. doi: 10.1007/s10620-014-3290-4. Epub 2014 Aug 17. PubMed
Human somatic cell mutagenesis creates genetically tractable sarcomas. Molyneux SD, Waterhouse PD, Shelton D, Shao YW, Watling CM, Tang QL, Harris IS, Dickson BC, Tharmapalan P, Sandve GK, Zhang X, Bailey SD, Berman H, Wunder JS, Izsvak Z, Lupien M, Mak TW, Khokha R. Nat Genet. 2014 Sep;46(9):964-72. doi: 10.1038/ng.3065. Epub 2014 Aug 17. PubMed
Complementation for an essential ancillary non-structural protein function across parvovirus genera. Mihaylov IS, Cotmore SF, Tattersall P. Virology. 2014 Nov;468-470:226-37. doi: 10.1016/j.virol.2014.07.043. Epub 2014 Sep 6. PubMed
IL4 limits the efficacy of tumor-targeted antibody therapy in a murine model. Surana R, Wang S, Xu W, Jablonski SA, Weiner LM. Cancer Immunol Res. 2014 Nov;2(11):1103-12. doi: 10.1158/2326-6066.CIR-14-0103. Epub 2014 Sep 9. PubMed
Spatial control of Cdc42 signalling by a GM130-RasGRF complex regulates polarity and tumorigenesis. Baschieri F, Confalonieri S, Bertalot G, Di Fiore PP, Dietmaier W, Leist M, Crespo P, Macara IG, Farhan H. Nat Commun. 2014 Sep 11;5:4839. doi: 10.1038/ncomms5839. PubMed
Interleukin-like epithelial-to-mesenchymal transition inducer activity is controlled by proteolytic processing and plasminogen-urokinase plasminogen activator receptor system-regulated secretion during breast cancer progression. Csiszar A, Kutay B, Wirth S, Schmidt U, Macho-Maschler S, Schreiber M, Alacakaptan M, Vogel GF, Aumayr K, Huber LA, Beug H. Breast Cancer Res. 2014 Sep 9;16(5):433. doi: 10.1186/s13058-014-0433-7. PubMed
CERS2 suppresses tumor cell invasion and is associated with decreased V-ATPase and MMP-2/MMP-9 activities in breast cancer. Fan SH, Wang YY, Lu J, Zheng YL, Wu DM, Zhang ZF, Shan Q, Hu B, Li MQ, Cheng W. J Cell Biochem. 2015 Apr;116(4):502-13. doi: 10.1002/jcb.24978. PubMed
DDX3 DEAD-box RNA helicase is a host factor that restricts hepatitis B virus replication at the transcriptional level. Ko C, Lee S, Windisch MP, Ryu WS. J Virol. 2014 Dec;88(23):13689-98. doi: 10.1128/JVI.02035-14. Epub 2014 Sep 17. PubMed

Associated Plasmids

Activation of the RIG-I pathway during influenza vaccination enhances the germinal center reaction, promotes T follicular helper cell induction, and provides a dose-sparing effect and protective immunity. Kulkarni RR, Rasheed MA, Bhaumik SK, Ranjan P, Cao W, Davis C, Marisetti K, Thomas S, Gangappa S, Sambhara S, Murali-Krishna K. J Virol. 2014 Dec;88(24):13990-4001. doi: 10.1128/JVI.02273-14. Epub 2014 Sep 24. PubMed
Bortezomib sensitizes primary meningioma cells to TRAIL-induced apoptosis by enhancing formation of the death-inducing signaling complex. Koschny R, Boehm C, Sprick MR, Haas TL, Holland H, Xu LX, Krupp W, Mueller WC, Bauer M, Koschny T, Keller M, Sinn P, Meixensberger J, Walczak H, Ganten TM. J Neuropathol Exp Neurol. 2014 Nov;73(11):1034-46. doi: 10.1097/NEN.0000000000000129. PubMed
A PTCH1 homolog transcriptionally activated by p53 suppresses Hedgehog signaling. Chung JH, Larsen AR, Chen E, Bunz F. J Biol Chem. 2014 Nov 21;289(47):33020-31. doi: 10.1074/jbc.M114.597203. Epub 2014 Oct 8. PubMed
The SNAI1 3'UTR functions as a sponge for multiple migration-/invasion-related microRNAs. Li J, Yu H, Xi M, Ma D, Lu X. Tumour Biol. 2015 Feb;36(2):1067-72. doi: 10.1007/s13277-014-2733-z. Epub 2014 Oct 19. PubMed
Vascular channels formed by subpopulations of PECAM1+ melanoma cells. Dunleavey JM, Xiao L, Thompson J, Kim MM, Shields JM, Shelton SE, Irvin DM, Brings VE, Ollila DW, Brekken RA, Dayton PA, Melero-Martin JM, Dudley AC. Nat Commun. 2014 Oct 22;5:5200. doi: 10.1038/ncomms6200. PubMed
Robo4 vaccines induce antibodies that retard tumor growth. Zhuang X, Ahmed F, Zhang Y, Ferguson HJ, Steele JC, Steven NM, Nagy Z, Heath VL, Toellner KM, Bicknell R. Angiogenesis. 2015 Jan;18(1):83-95. doi: 10.1007/s10456-014-9448-z. Epub 2014 Oct 28. PubMed
Functional analysis of prognostic gene expression network genes in metastatic breast cancer models. Geiger TR, Ha NH, Faraji F, Michael HT, Rodriguez L, Walker RC, Green JE, Simpson RM, Hunter KW. PLoS One. 2014 Nov 4;9(11):e111813. doi: 10.1371/journal.pone.0111813. eCollection 2014. PubMed
The protein phosphatase 2A inhibitor LB100 sensitizes ovarian carcinoma cells to cisplatin-mediated cytotoxicity. Chang KE, Wei BR, Madigan JP, Hall MD, Simpson RM, Zhuang Z, Gottesman MM. Mol Cancer Ther. 2015 Jan;14(1):90-100. doi: 10.1158/1535-7163.MCT-14-0496. Epub 2014 Nov 5. PubMed
The Hippo pathway is controlled by Angiotensin II signaling and its reactivation induces apoptosis in podocytes. Wennmann DO, Vollenbroker B, Eckart AK, Bonse J, Erdmann F, Wolters DA, Schenk LK, Schulze U, Kremerskothen J, Weide T, Pavenstadt H. Cell Death Dis. 2014 Nov 13;5:e1519. doi: 10.1038/cddis.2014.476. PubMed
Stable suppression of myostatin gene expression in goat fetal fibroblast cells by lentiviral vector-mediated RNAi. Patel UA, Patel AK, Joshi CG. Biotechnol Prog. 2015 Mar;31(2):452-9. doi: 10.1002/btpr.2022. Epub 2014 Nov 24. PubMed
Inhibition of class I HDACs abrogates the dominant effect of MLL-AF4 by activation of wild-type MLL. Ahmad K, Katryniok C, Scholz B, Merkens J, Loscher D, Marschalek R, Steinhilber D. Oncogenesis. 2014 Nov 17;3:e127. doi: 10.1038/oncsis.2014.39. PubMed
MNKs act as a regulatory switch for eIF4E1 and eIF4E3 driven mRNA translation in DLBCL. Landon AL, Muniandy PA, Shetty AC, Lehrmann E, Volpon L, Houng S, Zhang Y, Dai B, Peroutka R, Mazan-Mamczarz K, Steinhardt J, Mahurkar A, Becker KG, Borden KL, Gartenhaus RB. Nat Commun. 2014 Nov 18;5:5413. doi: 10.1038/ncomms6413. PubMed
Silencing long noncoding RNAs with genome-editing tools. Gutschner T. Methods Mol Biol. 2015;1239:241-50. doi: 10.1007/978-1-4939-1862-1_13. PubMed
Prediction and quantification of bioactive microbiota metabolites in the mouse gut. Sridharan GV, Choi K, Klemashevich C, Wu C, Prabakaran D, Pan LB, Steinmeyer S, Mueller C, Yousofshahi M, Alaniz RC, Lee K, Jayaraman A. Nat Commun. 2014 Nov 20;5:5492. doi: 10.1038/ncomms6492. PubMed
Inhibition of autophagy as a new means of improving chemotherapy efficiency in high-LC3B triple-negative breast cancers. Lefort S, Joffre C, Kieffer Y, Givel AM, Bourachot B, Zago G, Bieche I, Dubois T, Meseure D, Vincent-Salomon A, Camonis J, Mechta-Grigoriou F. Autophagy. 2014;10(12):2122-42. doi: 10.4161/15548627.2014.981788. PubMed
Mitochondrial DNA haplogroup B5 confers genetic susceptibility to Alzheimer's disease in Han Chinese. Bi R, Zhang W, Yu D, Li X, Wang HZ, Hu QX, Zhang C, Lu W, Ni J, Fang Y, Li T, Yao YG. Neurobiol Aging. 2015 Mar;36(3):1604.e7-16. doi: 10.1016/j.neurobiolaging.2014.10.009. Epub 2014 Oct 22. PubMed
Deficiency in the mitochondrial apoptotic pathway reveals the toxic potential of autophagy under ER stress conditions. Deegan S, Saveljeva S, Logue SE, Pakos-Zebrucka K, Gupta S, Vandenabeele P, Bertrand MJ, Samali A. Autophagy. 2014;10(11):1921-36. doi: 10.4161/15548627.2014.981790. PubMed
Xylosyltransferase-1 expression is refractory to inhibition by the inflammatory cytokines tumor necrosis factor alpha and IL-1beta in nucleus pulposus cells: novel regulation by AP-1, Sp1, and Sp3. Ye W, Zhou J, Markova DZ, Tian Y, Li J, Anderson DG, Shapiro IM, Risbud MV. Am J Pathol. 2015 Feb;185(2):485-95. doi: 10.1016/j.ajpath.2014.09.021. Epub 2014 Dec 2. PubMed
Increasing cisplatin sensitivity by schedule-dependent inhibition of AKT and Chk1. Duan L, Perez RE, Hansen M, Gitelis S, Maki CG. Cancer Biol Ther. 2014;15(12):1600-12. doi: 10.4161/15384047.2014.961876. PubMed
Dysregulated autophagy in the RPE is associated with increased susceptibility to oxidative stress and AMD. Mitter SK, Song C, Qi X, Mao H, Rao H, Akin D, Lewin A, Grant M, Dunn W Jr, Ding J, Bowes Rickman C, Boulton M. Autophagy. 2014;10(11):1989-2005. doi: 10.4161/auto.36184. PubMed
c-Src deactivation by the polyphenol 3-O-caffeoylquinic acid abrogates reactive oxygen species-mediated glutamate release from microglia and neuronal excitotoxicity. Socodato R, Portugal CC, Canedo T, Domith I, Oliveira NA, Paes-de-Carvalho R, Relvas JB, Cossenza M. Free Radic Biol Med. 2015 Feb;79:45-55. doi: 10.1016/j.freeradbiomed.2014.11.019. Epub 2014 Dec 5. PubMed
The neutral sphingomyelinase pathway regulates packaging of the prion protein into exosomes. Guo BB, Bellingham SA, Hill AF. J Biol Chem. 2015 Feb 6;290(6):3455-67. doi: 10.1074/jbc.M114.605253. Epub 2014 Dec 10. PubMed
A Phospho-SIM in the Antiviral Protein PML is Required for Its Recruitment to HSV-1 Genomes. Smith MC, Box AC, Haug JS, Lane WS, Davido DJ. Cells. 2014 Dec 10;3(4):1131-58. doi: 10.3390/cells3041131. PubMed
Knockdown of the Cell Cycle Inhibitor p21 Enhances Cartilage Formation by Induced Pluripotent Stem Cells. Diekman BO, Thakore PI, O'Connor SK, Willard VP, Brunger JM, Christoforou N, Leong KW, Gersbach CA, Guilak F. Tissue Eng Part A. 2015 Apr;21(7-8):1261-74. doi: 10.1089/ten.TEA.2014.0240. Epub 2015 Jan 23. PubMed
Targeting the effector domain of the myristoylated alanine rich C-kinase substrate enhances lung cancer radiation sensitivity. Rohrbach TD, Jarboe JS, Anderson JC, Trummell HQ, Hicks PH, Weaver AN, Yang ES, Oster RA, Deshane JS, Steele C, Siegal GP, Bonner JA, Willey CD. Int J Oncol. 2015 Mar;46(3):1079-88. doi: 10.3892/ijo.2014.2799. Epub 2014 Dec 17. PubMed
Reversal of Mutant KRAS-Mediated Apoptosis Resistance by Concurrent Noxa/Bik Induction and Bcl-2/Bcl-xL Antagonism in Colon Cancer Cells. Okamoto K, Zaanan A, Kawakami H, Huang S, Sinicrope FA. Mol Cancer Res. 2015 Apr;13(4):659-69. doi: 10.1158/1541-7786.MCR-14-0476. Epub 2014 Dec 29. PubMed
Inhibition of autophagic turnover in beta-cells by fatty acids and glucose leads to apoptotic cell death. Mir SU, George NM, Zahoor L, Harms R, Guinn Z, Sarvetnick NE. J Biol Chem. 2015 Mar 6;290(10):6071-85. doi: 10.1074/jbc.M114.605345. Epub 2014 Dec 29. PubMed
Role of the clathrin adaptor PICALM in normal hematopoiesis and polycythemia vera pathophysiology. Ishikawa Y, Maeda M, Pasham M, Aguet F, Tacheva-Grigorova SK, Masuda T, Yi H, Lee SU, Xu J, Teruya-Feldstein J, Ericsson M, Mullally A, Heuser J, Kirchhausen T, Maeda T. Haematologica. 2015 Apr;100(4):439-51. doi: 10.3324/haematol.2014.119537. Epub 2014 Dec 31. PubMed
Endoplasmic reticulum stress induces ligand-independent TNFR1-mediated necroptosis in L929 cells. Saveljeva S, Mc Laughlin SL, Vandenabeele P, Samali A, Bertrand MJ. Cell Death Dis. 2015 Jan 8;6:e1587. doi: 10.1038/cddis.2014.548. PubMed
Filamin C, a dysregulated protein in cancer revealed by label-free quantitative proteomic analyses of human gastric cancer cells. Qiao J, Cui SJ, Xu LL, Chen SJ, Yao J, Jiang YH, Peng G, Fang CY, Yang PY, Liu F. Oncotarget. 2015 Jan 20;6(2):1171-89. PubMed
Expression of the potential therapeutic target CXXC5 in primary acute myeloid leukemia cells - high expression is associated with adverse prognosis as well as altered intracellular signaling and transcriptional regulation. Bruserud O, Reikvam H, Fredly H, Skavland J, Hagen KM, van Hoang TT, Brenner AK, Kadi A, Astori A, Gjertsen BT, Pendino F. Oncotarget. 2015 Feb 20;6(5):2794-811. PubMed
A novel cytostatic form of autophagy in sensitization of non-small cell lung cancer cells to radiation by vitamin D and the vitamin D analog, EB 1089. Sharma K, Goehe RW, Di X, Hicks MA 2nd, Torti SV, Torti FM, Harada H, Gewirtz DA. Autophagy. 2014;10(12):2346-61. doi: 10.4161/15548627.2014.993283. PubMed
Prolyl-4-hydroxylase domain protein 2 controls NF-kappaB/p65 transactivation and enhances the catabolic effects of inflammatory cytokines on cells of the nucleus pulposus. Li J, Yuan W, Jiang S, Ye W, Yang H, Shapiro IM, Risbud MV. J Biol Chem. 2015 Mar 13;290(11):7195-207. doi: 10.1074/jbc.M114.611483. Epub 2015 Jan 29. PubMed
YAP-mediated induction of monoacylglycerol lipase restrains oncogenic transformation. Tang ED, Wang CY. Cell Signal. 2015 Apr;27(4):836-40. doi: 10.1016/j.cellsig.2015.01.011. Epub 2015 Jan 28. PubMed
UBE3C promotes growth and metastasis of renal cell carcinoma via activating Wnt/beta-catenin pathway. Wen JL, Wen XF, Li RB, Jin YC, Wang XL, Zhou L, Chen HX. PLoS One. 2015 Feb 6;10(2):e0115622. doi: 10.1371/journal.pone.0115622. eCollection 2015. PubMed
The inhibitory effects of anacardic acid on hepatitis C virus life cycle. Hundt J, Li Z, Liu Q. PLoS One. 2015 Feb 6;10(2):e0117514. doi: 10.1371/journal.pone.0117514. eCollection 2015. PubMed
DNA damage-induced regulatory interplay between DAXX, p53, ATM kinase and Wip1 phosphatase. Brazina J, Svadlenka J, Macurek L, Andera L, Hodny Z, Bartek J, Hanzlikova H. Cell Cycle. 2015;14(3):375-87. doi: 10.4161/15384101.2014.988019. PubMed
Lysyl hydroxylase 2 induces a collagen cross-link switch in tumor stroma. Chen Y, Terajima M, Yang Y, Sun L, Ahn YH, Pankova D, Puperi DS, Watanabe T, Kim MP, Blackmon SH, Rodriguez J, Liu H, Behrens C, Wistuba II, Minelli R, Scott KL, Sanchez-Adams J, Guilak F, Pati D, Thilaganathan N, Burns AR, Creighton CJ, Martinez ED, Zal T, Grande-Allen KJ, Yamauchi M, Kurie JM. J Clin Invest. 2015 Mar 2;125(3):1147-62. doi: 10.1172/JCI74725. Epub 2015 Feb 9. PubMed
The functional interactome of PYHIN immune regulators reveals IFIX is a sensor of viral DNA. Diner BA, Li T, Greco TM, Crow MS, Fuesler JA, Wang J, Cristea IM. Mol Syst Biol. 2015 Feb 9;11(1):787. doi: 10.15252/msb.20145808. PubMed
PROX1 promotes hepatocellular carcinoma proliferation and sorafenib resistance by enhancing beta-catenin expression and nuclear translocation. Liu Y, Ye X, Zhang JB, Ouyang H, Shen Z, Wu Y, Wang W, Wu J, Tao S, Yang X, Qiao K, Zhang J, Liu J, Fu Q, Xie Y. Oncogene. 2015 Feb 16. doi: 10.1038/onc.2015.7. PubMed
mTORC1 upregulation via ERK-dependent gene expression change confers intrinsic resistance to MEK inhibitors in oncogenic KRas-mutant cancer cells. Komatsu N, Fujita Y, Matsuda M, Aoki K. Oncogene. 2015 Feb 23. doi: 10.1038/onc.2015.16. PubMed
Cryopreservation of microencapsulated murine mesenchymal stem cells genetically engineered to secrete erythropoietin. Gurruchaga H, Ciriza J, Saenz Del Burgo L, Rodriguez-Madoz JR, Santos E, Prosper F, Hernandez RM, Orive G, Pedraz JL. Int J Pharm. 2015 May 15;485(1-2):15-24. doi: 10.1016/j.ijpharm.2015.02.047. Epub 2015 Feb 20. PubMed
ICAM1 depletion reduces spinal metastasis formation in vivo and improves neurological outcome. Broggini T, Czabanka M, Piffko A, Harms C, Hoffmann C, Mrowka R, Wenke F, Deutsch U, Grotzinger C, Vajkoczy P. Eur Spine J. 2015 Feb 25. PubMed
Novel lentiviral-inducible transgene expression systems and versatile single-plasmid reporters for in vitro and in vivo cancer biology studies. Shuen WH, Kan R, Yu Z, Lung HL, Lung ML. Cancer Gene Ther. 2015 Feb 27. doi: 10.1038/cgt.2015.9. PubMed

Associated Plasmids

Highly efficient Cas9-mediated transcriptional programming. Chavez A, Scheiman J, Vora S, Pruitt BW, Tuttle M, P R Iyer E, Lin S, Kiani S, Guzman CD, Wiegand DJ, Ter-Ovanesyan D, Braff JL, Davidsohn N, Housden BE, Perrimon N, Weiss R, Aach J, Collins JJ, Church GM. Nat Methods. 2015 Mar 2. doi: 10.1038/nmeth.3312. PubMed

Associated Plasmids

Fatty acid elongase 7 catalyzes lipidome remodeling essential for human cytomegalovirus replication. Purdy JG, Shenk T, Rabinowitz JD. Cell Rep. 2015 Mar 3;10(8):1375-85. doi: 10.1016/j.celrep.2015.02.003. Epub 2015 Feb 26. PubMed
Stemness factor Sall4 is required for DNA damage response in embryonic stem cells. Xiong J, Todorova D, Su NY, Kim J, Lee PJ, Shen Z, Briggs SP, Xu Y. J Cell Biol. 2015 Mar 2;208(5):513-20. doi: 10.1083/jcb.201408106. PubMed
Rad51-mediated replication fork reversal is a global response to genotoxic treatments in human cells. Zellweger R, Dalcher D, Mutreja K, Berti M, Schmid JA, Herrador R, Vindigni A, Lopes M. J Cell Biol. 2015 Mar 2;208(5):563-79. doi: 10.1083/jcb.201406099. PubMed
CD47 agonist peptides induce programmed cell death in refractory chronic lymphocytic leukemia B cells via PLCgamma1 activation: evidence from mice and humans. Martinez-Torres AC, Quiney C, Attout T, Boullet H, Herbi L, Vela L, Barbier S, Chateau D, Chapiro E, Nguyen-Khac F, Davi F, Le Garff-Tavernier M, Moumne R, Sarfati M, Karoyan P, Merle-Beral H, Launay P, Susin SA. PLoS Med. 2015 Mar 3;12(3):e1001796. doi: 10.1371/journal.pmed.1001796. eCollection 2015 Mar. PubMed
DNA damage shifts circadian clock time via Hausp-dependent Cry1 stabilization. Papp SJ, Huber AL, Jordan SD, Kriebs A, Nguyen M, Moresco JJ, Yates JR, Lamia KA. Elife. 2015 Mar 10;4. doi: 10.7554/eLife.04883. PubMed
Plexin-B2 promotes invasive growth of malignant glioma. Le AP, Huang Y, Pingle SC, Kesari S, Wang H, Yong RL, Zou H, Friedel RH. Oncotarget. 2015 Mar 30;6(9):7293-304. PubMed

Associated Plasmids

Interleukin 6 inhibits HBV entry through NTCP down regulation. Bouezzedine F, Fardel O, Gripon P. Virology. 2015 Jul;481:34-42. doi: 10.1016/j.virol.2015.02.026. Epub 2015 Mar 9. PubMed
Selective Distal Enhancer Control of the Mmp13 Gene Identified through Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR) Genomic Deletions. Meyer MB, Benkusky NA, Pike JW. J Biol Chem. 2015 Apr 24;290(17):11093-107. doi: 10.1074/jbc.M115.648394. Epub 2015 Mar 15. PubMed
IFI44 suppresses HIV-1 LTR promoter activity and facilitates its latency. Power D, Santoso N, Dieringer M, Yu J, Huang H, Simpson S, Seth I, Miao H, Zhu J. Virology. 2015 Jul;481:142-50. doi: 10.1016/j.virol.2015.02.046. Epub 2015 Mar 14. PubMed
miR-191 promotes tumorigenesis of human colorectal cancer through targeting C/EBPbeta. Zhang XF, Li KK, Gao L, Li SZ, Chen K, Zhang JB, Wang D, Tu RF, Zhang JX, Tao KX, Wang G, Zhang XD. Oncotarget. 2015 Feb 28;6(6):4144-58. PubMed
Modeling and study of the mechanism of dilated cardiomyopathy using induced pluripotent stem cells derived from individuals with Duchenne muscular dystrophy. Lin B, Li Y, Han L, Kaplan AD, Ao Y, Kalra S, Bett GC, Rasmusson RL, Denning C, Yang L. Dis Model Mech. 2015 May;8(5):457-66. doi: 10.1242/dmm.019505. Epub 2015 Mar 19. PubMed
Borna disease virus phosphoprotein modulates epigenetic signaling in neurons to control viral replication. Bonnaud EM, Szelechowski M, Betourne A, Foret C, Thouard A, Gonzalez-Dunia D, Malnou CE. J Virol. 2015 Jun;89(11):5996-6008. doi: 10.1128/JVI.00454-15. Epub 2015 Mar 25. PubMed
CCM2-CCM3 interaction stabilizes their protein expression and permits endothelial network formation. Draheim KM, Li X, Zhang R, Fisher OS, Villari G, Boggon TJ, Calderwood DA. J Cell Biol. 2015 Mar 30;208(7):987-1001. doi: 10.1083/jcb.201407129. PubMed
Identification and characterization of nonhistone chromatin proteins: human positive coactivator 4 as a candidate. Kumari S, Das C, Sikder S, Kumar M, Bachu M, Ranga U, Kundu TK. Methods Mol Biol. 2015;1288:245-72. doi: 10.1007/978-1-4939-2474-5_14. PubMed
TGF-beta suppression of HBV RNA through AID-dependent recruitment of an RNA exosome complex. Liang G, Liu G, Kitamura K, Wang Z, Chowdhury S, Monjurul AM, Wakae K, Koura M, Shimadu M, Kinoshita K, Muramatsu M. PLoS Pathog. 2015 Apr 2;11(4):e1004780. doi: 10.1371/journal.ppat.1004780. eCollection 2015 Apr. PubMed
Caveolin-1 is transcribed from a hypermethylated promoter to mediate colonocyte differentiation and apoptosis. Dasgupta N, Kumar Thakur B, Ta A, Das S. Exp Cell Res. 2015 Jun 10;334(2):323-36. doi: 10.1016/j.yexcr.2015.03.020. Epub 2015 Apr 1. PubMed
Latent transforming growth factor-beta binding proteins (LTBP-1 and LTBP-2) and gingiva keratinization. Chiang MS, Yang JR, Liao SC, Hsu CC, Hsu CW, Yuan K. Oral Dis. 2015 Apr 10. doi: 10.1111/odi.12344. PubMed
The DNA helicase recql4 is required for normal osteoblast expansion and osteosarcoma formation. Ng AJ, Walia MK, Smeets MF, Mutsaers AJ, Sims NA, Purton LE, Walsh NC, Martin TJ, Walkley CR. PLoS Genet. 2015 Apr 10;11(4):e1005160. doi: 10.1371/journal.pgen.1005160. eCollection 2015 Apr. PubMed
Methods of Reprogramming to Induced Pluripotent Stem Cell Associated with Chromosomal Integrity and Delineation of a Chromosome 5q Candidate Region for Growth Advantage. Sobol M, Raykova D, Cavelier L, Khalfallah A, Schuster J, Dahl N. Stem Cells Dev. 2015 Sep 1;24(17):2032-40. doi: 10.1089/scd.2015.0061. Epub 2015 May 18. PubMed
A pooled shRNA screen for regulators of primary mammary stem and progenitor cells identifies roles for Asap1 and Prox1. Sheridan JM, Ritchie ME, Best SA, Jiang K, Beck TJ, Vaillant F, Liu K, Dickins RA, Smyth GK, Lindeman GJ, Visvader JE. BMC Cancer. 2015 Apr 3;15:221. doi: 10.1186/s12885-015-1187-z. PubMed
Loss of GM130 in breast cancer cells and its effects on cell migration, invasion and polarity. Baschieri F, Uetz-von Allmen E, Legler DF, Farhan H. Cell Cycle. 2015;14(8):1139-47. doi: 10.1080/15384101.2015.1007771. PubMed
Quantification of cell fusion events human breast cancer cells and breast epithelial cells using a Cre-LoxP-based double fluorescence reporter system. Mohr M, Tosun S, Arnold WH, Edenhofer F, Zanker KS, Dittmar T. Cell Mol Life Sci. 2015 Apr 22. PubMed
Cellular metabolism of unnatural sialic acid precursors. Pham ND, Fermaintt CS, Rodriguez AC, McCombs JE, Nischan N, Kohler JJ. Glycoconj J. 2015 May 10. PubMed
Overexpression of the Promigratory and Prometastatic PTK7 Receptor Is Associated with an Adverse Clinical Outcome in Colorectal Cancer. Lhoumeau AC, Martinez S, Boher JM, Monges G, Castellano R, Goubard A, Doremus M, Poizat F, Lelong B, de Chaisemartin C, Bardin F, Viens P, Raoul JL, Prebet T, Aurrand-Lions M, Borg JP, Goncalves A. PLoS One. 2015 May 11;10(5):e0123768. doi: 10.1371/journal.pone.0123768. eCollection 2015. PubMed
Inhibition of histone methyltransferases SUV39H1 and G9a leads to neuroprotection in an in vitro model of cerebral ischemia. Schweizer S, Harms C, Lerch H, Flynn J, Hecht J, Yildirim F, Meisel A, Marschenz S. J Cereb Blood Flow Metab. 2015 May 13. doi: 10.1038/jcbfm.2015.99. PubMed
Reduced efficiency of sarcolipin-dependent respiration in myocytes from humans with severe obesity. Paran CW, Verkerke AR, Heden TD, Park S, Zou K, Lawson HA, Song H, Turk J, Houmard JA, Funai K. Obesity (Silver Spring). 2015 Jul;23(7):1440-9. doi: 10.1002/oby.21123. Epub 2015 May 13. PubMed
Regulation of autophagic cell death by glycogen synthase kinase-3beta in adult hippocampal neural stem cells following insulin withdrawal. Ha S, Ryu HY, Chung KM, Baek SH, Kim EK, Yu SW. Mol Brain. 2015 May 19;8:30. doi: 10.1186/s13041-015-0119-9. PubMed
Death of Neurons following Injury Requires Conductive Neuronal Gap Junction Channels but Not a Specific Connexin. Fontes JD, Ramsey J, Polk JM, Koop A, Denisova JV, Belousov AB. PLoS One. 2015 May 27;10(5):e0125395. doi: 10.1371/journal.pone.0125395. eCollection 2015. PubMed
Human Induced Pluripotent Stem Cell-Derived Microvesicles Transmit RNAs and Proteins to Recipient Mature Heart Cells Modulating Cell Fate and Behavior. Bobis-Wozowicz S, Kmiotek K, Sekula M, Kedracka-Krok S, Kamycka E, Adamiak M, Jankowska U, Madetko-Talowska A, Sarna M, Bik-Multanowski M, Kolcz J, Boruczkowski D, Madeja Z, Dawn B, Zuba-Surma EK. Stem Cells. 2015 Jun 1. doi: 10.1002/stem.2078. PubMed
E2F1-Mediated Induction of NFYB Attenuates Apoptosis via Joint Regulation of a Pro-Survival Transcriptional Program. Jiang X, Nevins JR, Shats I, Chi JT. PLoS One. 2015 Jun 3;10(6):e0127951. doi: 10.1371/journal.pone.0127951. eCollection 2015. PubMed
Lentiviral transduction of mammary epithelial cells. Iggo R, Richard E. Methods Mol Biol. 2015;1293:137-60. doi: 10.1007/978-1-4939-2519-3_8. PubMed
Reprogramming fibroblasts toward cardiomyocytes, neural stem cells and hepatocytes by cell activation and signaling-directed lineage conversion. Zhu S, Wang H, Ding S. Nat Protoc. 2015 Jul;10(7):959-73. doi: 10.1038/nprot.2015.059. Epub 2015 Jun 4. PubMed
CRISPR-Cas9-mediated gene knockout in primary human airway epithelial cells reveals a proinflammatory role for MUC18. Chu HW, Rios C, Huang C, Wesolowska-Andersen A, Burchard EG, O'Connor BP, Fingerlin TE, Nichols D, Reynolds SD, Seibold MA. Gene Ther. 2015 Jul 2. doi: 10.1038/gt.2015.53. PubMed
Forward Programming of Cardiac Stem Cells by Homogeneous Transduction with MYOCD plus TBX5. Belian E, Noseda M, Abreu Paiva MS, Leja T, Sampson R, Schneider MD. PLoS One. 2015 Jun 5;10(6):e0125384. doi: 10.1371/journal.pone.0125384. eCollection 2015. PubMed
Evidence that synthetic lethality underlies the mutual exclusivity of oncogenic KRAS and EGFR mutations in lung adenocarcinoma. Unni AM, Lockwood WW, Zejnullahu K, Lee-Lin SQ, Varmus H. Elife. 2015 Jun 5;4:e06907. doi: 10.7554/eLife.06907. PubMed
Decoy receptors block TRAIL sensitivity at a supracellular level: the role of stromal cells in controlling tumour TRAIL sensitivity. O'Leary L, van der Sloot AM, Reis CR, Deegan S, Ryan AE, Dhami SP, Murillo LS, Cool RH, de Sampaio PC, Thompson K, Murphy G, Quax WJ, Serrano L, Samali A, Szegezdi E. Oncogene. 2015 Jun 8. doi: 10.1038/onc.2015.180. PubMed
Tryptophan derivatives regulate the transcription of Oct4 in stem-like cancer cells. Cheng J, Li W, Kang B, Zhou Y, Song J, Dan S, Yang Y, Zhang X, Li J, Yin S, Cao H, Yao H, Zhu C, Yi W, Zhao Q, Xu X, Zheng M, Zheng S, Li L, Shen B, Wang YJ. Nat Commun. 2015 Jun 10;6:7209. doi: 10.1038/ncomms8209. PubMed
Lysine-specific demethylase (LSD1/KDM1A) and MYCN cooperatively repress tumor suppressor genes in neuroblastoma. Amente S, Milazzo G, Sorrentino MC, Ambrosio S, Di Palo G, Lania L, Perini G, Majello B. Oncotarget. 2015 Jun 10;6(16):14572-83. PubMed
Regulation of vascular endothelial growth factor receptor function in angiogenesis by numb and numb-like. van Lessen M, Nakayama M, Kato K, Kim JM, Kaibuchi K, Adams RH. Arterioscler Thromb Vasc Biol. 2015 Aug;35(8):1815-25. doi: 10.1161/ATVBAHA.115.305473. Epub 2015 Jun 11. PubMed
Transcriptional co-factor Transducin beta-like (TBL) 1 acts as a checkpoint in pancreatic cancer malignancy. Stoy C, Sundaram A, Rios Garcia M, Wang X, Seibert O, Zota A, Wendler S, Mannle D, Hinz U, Sticht C, Muciek M, Gretz N, Rose AJ, Greiner V, Hofmann TG, Bauer A, Hoheisel J, Berriel Diaz M, Gaida MM, Werner J, Schafmeier T, Strobel O, Herzig S. EMBO Mol Med. 2015 Jun 12;7(8):1048-62. doi: 10.15252/emmm.201404837. PubMed
Parkinson-causing alpha-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation. Dettmer U, Newman AJ, Soldner F, Luth ES, Kim NC, von Saucken VE, Sanderson JB, Jaenisch R, Bartels T, Selkoe D. Nat Commun. 2015 Jun 16;6:7314. doi: 10.1038/ncomms8314. PubMed
Lhx8 mediated Wnt and TGFbeta pathways in tooth development and regeneration. Zhou C, Yang G, Chen M, Wang C, He L, Xiang L, Chen D, Ling J, Mao JJ. Biomaterials. 2015 Sep;63:35-46. doi: 10.1016/j.biomaterials.2015.06.004. Epub 2015 Jun 3. PubMed
Binding of the sphingolipid S1P to hTERT stabilizes telomerase at the nuclear periphery by allosterically mimicking protein phosphorylation. Panneer Selvam S, De Palma RM, Oaks JJ, Oleinik N, Peterson YK, Stahelin RV, Skordalakes E, Ponnusamy S, Garrett-Mayer E, Smith CD, Ogretmen B. Sci Signal. 2015 Jun 16;8(381):ra58. doi: 10.1126/scisignal.aaa4998. PubMed
Pellino-1 positively regulates Toll-like Receptor (TLR) 2 and TLR4 signaling and is suppressed upon induction of endotoxin tolerance. Murphy M, Xiong Y, Pattabiraman G, Qiu F, Medvedev AE. J Biol Chem. 2015 Jun 16. pii: jbc.M115.640128. PubMed
The ORF61 protein encoded by Simian Varicella Virus and Varicella Zoster Virus inhibits NFkappaB signaling by interfering with IkappaBalpha degradation. Whitmer T, Malouli D, Uebelhoer LS, DeFilippis VR, Fruh K, Verweij MC. J Virol. 2015 Jun 17. pii: JVI.01149-15. PubMed
Induction of functional Brm protein from Brm knockout mice. Thompson KW, Marquez SB, Lu L, Reisman D. Oncoscience. 2015 Apr 18;2(4):349-61. eCollection 2015. PubMed
IGF1R/IRS1 signaling confers pathogenic activity on breast tumor cells lacking REST. Meyer K, Albaugh B, Schoenike B, Roopra A. Mol Cell Biol. 2015 Jun 22. pii: MCB.01149-14. PubMed
Expression of the multidrug transporter P-glycoprotein is inversely related to that of apoptosis-associated endogenous TRAIL. Souza PS, Madigan JP, Gillet JP, Kapoor K, Ambudkar SV, Maia RC, Gottesman MM, Leung Fung K. Exp Cell Res. 2015 Jun 19. pii: S0014-4827(15)30013-6. doi: 10.1016/j.yexcr.2015.06.005. PubMed
mPGES-1 in prostate cancer controls stemness and amplifies EGFR-driven oncogenicity. Finetti F, Terzuoli E, Giachetti A, Santi R, Villari D, Hanaka H, Radmark O, Ziche M, Donnini S. Endocr Relat Cancer. 2015 Jun 25. pii: ERC-15-0277. PubMed
Early growth response gene (EGR)-1 regulates leukotriene D4-induced cytokine transcription in Hodgkin lymphoma cells. Han H, Xue-Franzen Y, Miao X, Nagy E, Li N, Xu D, Sjoberg J, Bjorkholm M, Claesson HE. Prostaglandins Other Lipid Mediat. 2015 Jun 23. pii: S1098-8823(15)00075-1. doi: 10.1016/j.prostaglandins.2015.06.004. PubMed
Gene Silencing by RNAi in Mammalian Cells. Ponthan F, Yusoff NM, Soria NM, Heidenreich O, Coffey K. Curr Protoc Mol Biol. 2015 Jul 1;111:26.2.1-26.2.17. doi: 10.1002/0471142727.mb2602s111. PubMed
Increased titer and reduced lactate accumulation in recombinant retrovirus production through the down-regulation of HIF1 and PDK. Rodrigues AF, Guerreiro MR, Formas-Oliveira AS, Fernandes P, Blechert AK, Genzel Y, Alves PM, Hu WS, Coroadinha AS. Biotechnol Bioeng. 2015 Jul 1. doi: 10.1002/bit.25691. PubMed
ATP binding by NLRP7 is required for inflammasome activation in response to bacterial lipopeptides. Radian AD, Khare S, Chu LH, Dorfleutner A, Stehlik C. Mol Immunol. 2015 Jul 1. pii: S0161-5890(15)00437-X. doi: 10.1016/j.molimm.2015.06.013. PubMed
LMAN1 (ERGIC-53) is a potential carrier protein for matrix metalloproteinase-9 glycoprotein secretion. Duellman T, Burnett J, Shin A, Yang J. Biochem Biophys Res Commun. 2015 Jul 3. pii: S0006-291X(15)30222-9. doi: 10.1016/j.bbrc.2015.06.164. PubMed
Myogenic induction of adult and pluripotent stem cells using recombinant proteins. Perini I, Elia I, Lo Nigro A, Ronzoni F, Berardi E, Grosemans H, Fukada S, Sampaolesi M. Biochem Biophys Res Commun. 2015 Aug 28;464(3):755-61. doi: 10.1016/j.bbrc.2015.07.022. Epub 2015 Jul 8. PubMed
Use of Ferritin Expression, Regulated by Neural Cell-Specific Promoters in Human Adipose Tissue-Derived Mesenchymal Stem Cells, to Monitor Differentiation with Magnetic Resonance Imaging In Vitro. Song C, Wang J, Mo C, Mu S, Jiang X, Li X, Zhong S, Zhao Z, Zhou G. PLoS One. 2015 Jul 15;10(7):e0132480. doi: 10.1371/journal.pone.0132480. eCollection 2015. PubMed
Mutant p53-R273H mediates cancer cell survival and anoikis resistance through AKT-dependent suppression of BCL2-modifying factor (BMF). Tan BS, Tiong KH, Choo HL, Chung FF, Hii LW, Tan SH, Yap IK, Pani S, Khor NT, Wong SF, Rosli R, Cheong SK, Leong CO. Cell Death Dis. 2015 Jul 16;6:e1826. doi: 10.1038/cddis.2015.191. PubMed
Expression of an estrogen-regulated variant transcript of the peroxisomal branched chain fatty acid oxidase ACOX2 in breast carcinomas. Bjorklund SS, Kristensen VN, Seiler M, Kumar S, Alnaes GI, Ming Y, Kerrigan J, Naume B, Sachidanandam R, Bhanot G, Borresen-Dale AL, Ganesan S. BMC Cancer. 2015 Jul 17;15:524. doi: 10.1186/s12885-015-1510-8. PubMed
Dynamic Changes in Cytosolic ATP Levels in Cultured Glutamatergic Neurons During NMDA-Induced Synaptic Activity Supported by Glucose or Lactate. Lange SC, Winkler U, Andresen L, Byhro M, Waagepetersen HS, Hirrlinger J, Bak LK. Neurochem Res. 2015 Dec;40(12):2517-26. doi: 10.1007/s11064-015-1651-9. Epub 2015 Jul 17. PubMed
Overexpression of the MRI Reporter Genes Ferritin and Transferrin Receptor Affect Iron Homeostasis and Produce Limited Contrast in Mesenchymal Stem Cells. Pereira SM, Moss D, Williams SR, Murray P, Taylor A. Int J Mol Sci. 2015 Jul 8;16(7):15481-96. doi: 10.3390/ijms160715481. PubMed
A Genome-wide CRISPR Screen in Primary Immune Cells to Dissect Regulatory Networks. Parnas O, Jovanovic M, Eisenhaure TM, Herbst RH, Dixit A, Ye CJ, Przybylski D, Platt RJ, Tirosh I, Sanjana NE, Shalem O, Satija R, Raychowdhury R, Mertins P, Carr SA, Zhang F, Hacohen N, Regev A. Cell. 2015 Jul 30;162(3):675-86. doi: 10.1016/j.cell.2015.06.059. Epub 2015 Jul 16. PubMed
Spontaneous Cell Competition in Immortalized Mammalian Cell Lines. Penzo-Mendez AI, Chen YJ, Li J, Witze ES, Stanger BZ. PLoS One. 2015 Jul 22;10(7):e0132437. doi: 10.1371/journal.pone.0132437. eCollection 2015. PubMed
Polarity Protein Scrib Facilitates Endothelial Inflammatory Signaling. Kruse C, Kurz AR, Palfi K, Humbert PO, Sperandio M, Brandes RP, Fork C, Michaelis UR. Arterioscler Thromb Vasc Biol. 2015 Sep;35(9):1954-62. doi: 10.1161/ATVBAHA.115.305678. Epub 2015 Jul 23. PubMed
The homeobox gene DLX4 regulates erythro-megakaryocytic differentiation by stimulating IL-1beta and NF-kappaB signaling. Trinh BQ, Barengo N, Kim SB, Lee JS, Zweidler-McKay PA, Naora H. J Cell Sci. 2015 Aug 15;128(16):3055-67. doi: 10.1242/jcs.168187. Epub 2015 Jul 24. PubMed
The role of frataxin in doxorubicin-mediated cardiac hypertrophy. Mouli S, Nanayakkara G, AlAlasmari A, Eldoumani H, Fu X, Berlin A, Lohani M, Nie B, Arnold RD, Kavazis A, Smith F, Beyers R, Denney T, Dhanasekaran M, Zhong J, Quindry J, Amin R. Am J Physiol Heart Circ Physiol. 2015 Sep;309(5):H844-59. doi: 10.1152/ajpheart.00182.2015. Epub 2015 Jul 24. PubMed
Adhesion to fibronectin regulates Hippo signaling via the FAK-Src-PI3K pathway. Kim NG, Gumbiner BM. J Cell Biol. 2015 Aug 3;210(3):503-15. doi: 10.1083/jcb.201501025. Epub 2015 Jul 27. PubMed

Associated Plasmids

alpha-5 Laminin Synthesized by Human Pluripotent Stem Cells Promotes Self-Renewal. Laperle A, Hsiao C, Lampe M, Mortier J, Saha K, Palecek SP, Masters KS. Stem Cell Reports. 2015 Aug 11;5(2):195-206. doi: 10.1016/j.stemcr.2015.06.009. Epub 2015 Jul 30. PubMed
Genetic determinants of FOXM1 overexpression in epithelial ovarian cancer and functional contribution to cell cycle progression. Barger CJ, Zhang W, Hillman J, Stablewski AB, Higgins MJ, Vanderhyden BC, Odunsi K, Karpf AR. Oncotarget. 2015 Jul 16. PubMed

Associated Plasmids

The Mutant KRAS Gene Up-regulates BCL-XL Protein via STAT3 to Confer Apoptosis Resistance That Is Reversed by BIM Protein Induction and BCL-XL Antagonism. Zaanan A, Okamoto K, Kawakami H, Khazaie K, Huang S, Sinicrope FA. J Biol Chem. 2015 Sep 25;290(39):23838-49. doi: 10.1074/jbc.M115.657833. Epub 2015 Aug 5. PubMed
Nutlin-3 sensitizes nasopharyngeal carcinoma cells to cisplatin-induced cytotoxicity. Voon YL, Ahmad M, Wong PF, Husaini R, Ng WT, Leong CO, Lane DP, Khoo AS. Oncol Rep. 2015 Oct;34(4):1692-700. doi: 10.3892/or.2015.4177. Epub 2015 Aug 5. PubMed
CFTR inactivation by lentiviral vector-mediated RNA interference and CRISPR-Cas9 genome editing in human airway epithelial cells. Bellec J, Bacchetta M, Losa D, Anegon I, Chanson M, Nguyen TH. Curr Gene Ther. 2015;15(5):447-59. PubMed
Atypical protein kinase C induces cell transformation by disrupting Hippo/Yap signaling. Archibald A, Al-Masri M, Liew-Spilger A, McCaffrey L. Mol Biol Cell. 2015 Oct 15;26(20):3578-95. doi: 10.1091/mbc.E15-05-0265. Epub 2015 Aug 12. PubMed
Mucosally transplanted mesenchymal stem cells stimulate intestinal healing by promoting angiogenesis. Manieri NA, Mack MR, Himmelrich MD, Worthley DL, Hanson EM, Eckmann L, Wang TC, Stappenbeck TS. J Clin Invest. 2015 Sep;125(9):3606-18. doi: 10.1172/JCI81423. Epub 2015 Aug 17. PubMed
hVGAT-mCherry: A novel molecular tool for analysis of GABAergic neurons derived from human pluripotent stem cells. DeRosa BA, Belle KC, Thomas BJ, Cukier HN, Pericak-Vance MA, Vance JM, Dykxhoorn DM. Mol Cell Neurosci. 2015 Sep;68:244-57. doi: 10.1016/j.mcn.2015.08.007. Epub 2015 Aug 16. PubMed
Antisense-miR-21 enhances differentiation/apoptosis and reduces cancer stemness state on anaplastic thyroid cancer. Haghpanah V, Fallah P, Tavakoli R, Naderi M, Samimi H, Soleimani M, Larijani B. Tumour Biol. 2015 Aug 20. PubMed
Quantitative analysis of recombination between YFP and CFP genes of FRET biosensors introduced by lentiviral or retroviral gene transfer. Komatsubara AT, Matsuda M, Aoki K. Sci Rep. 2015 Aug 20;5:13283. doi: 10.1038/srep13283. PubMed
Retroviral Transduction of T Cells and T Cell Precursors. Simmons A, Alberola-Ila J. Methods Mol Biol. 2016;1323:99-108. doi: 10.1007/978-1-4939-2809-5_8. PubMed
Nuclear Localization of DNAJB6 Is Associated With Survival of Patients With Esophageal Cancer and Reduces AKT Signaling and Proliferation of Cancer Cells. Yu VZ, Wong VC, Dai W, Ko JM, Lam AK, Chan KW, Samant RS, Lung HL, Shuen WH, Law S, Chan YP, Lee NP, Tong DK, Law TT, Lee VH, Lung ML. Gastroenterology. 2015 Dec;149(7):1825-1836.e5. doi: 10.1053/j.gastro.2015.08.025. Epub 2015 Aug 22. PubMed
JAM-A regulates cortical dynein localization through Cdc42 to control planar spindle orientation during mitosis. Tuncay H, Brinkmann BF, Steinbacher T, Schurmann A, Gerke V, Iden S, Ebnet K. Nat Commun. 2015 Aug 26;6:8128. doi: 10.1038/ncomms9128. PubMed
CD45+ Cells Present Within Mesenchymal Stem Cell Populations Affect Network Formation of Blood-Derived Endothelial Outgrowth Cells. Peters EB, Christoforou N, Moore E, West JL, Truskey GA. Biores Open Access. 2015 Jan 1;4(1):75-88. doi: 10.1089/biores.2014.0029. eCollection 2015. PubMed
Pellino-3 promotes endotoxin tolerance and acts as a negative regulator of TLR2 and TLR4 signaling. Murphy MB, Xiong Y, Pattabiraman G, Manavalan TT, Qiu F, Medvedev AE. J Leukoc Biol. 2015 Dec;98(6):963-74. doi: 10.1189/jlb.2VMA0515-229RR. Epub 2015 Aug 26. PubMed
Predicting the molecular role of MEIS1 in esophageal squamous cell carcinoma. Rad A, Farshchian M, Forghanifard MM, Matin MM, Bahrami AR, Geerts D, A'rabi A, Memar B, Abbaszadegan MR. Tumour Biol. 2015 Aug 28. PubMed
Derivation of LIF-independent mouse iPS cells with modified Oct4. Hirai H, Firpo M, Kikyo N. Stem Cell Res. 2015 Sep;15(2):384-6. doi: 10.1016/j.scr.2015.08.005. Epub 2015 Aug 17. PubMed
Mutation of the BRCA1 SQ-cluster results in aberrant mitosis, reduced homologous recombination, and a compensatory increase in non-homologous end joining. Beckta JM, Dever SM, Gnawali N, Khalil A, Sule A, Golding SE, Rosenberg E, Narayanan A, Kehn-Hall K, Xu B, Povirk LF, Valerie K. Oncotarget. 2015 Sep 29;6(29):27674-87. doi: 10.18632/oncotarget.4876. PubMed
Asporin Is a Fibroblast-Derived TGF-beta1 Inhibitor and a Tumor Suppressor Associated with Good Prognosis in Breast Cancer. Maris P, Blomme A, Palacios AP, Costanza B, Bellahcene A, Bianchi E, Gofflot S, Drion P, Trombino GE, Di Valentin E, Cusumano PG, Maweja S, Jerusalem G, Delvenne P, Lifrange E, Castronovo V, Turtoi A. PLoS Med. 2015 Sep 1;12(9):e1001871. doi: 10.1371/journal.pmed.1001871. eCollection 2015 Sep. PubMed
p53-regulated autophagy is controlled by glycolysis and determines cell fate. Duan L, Perez RE, Davaadelger B, Dedkova EN, Blatter LA, Maki CG. Oncotarget. 2015 Sep 15;6(27):23135-56. PubMed
Identification of an oncogenic RAB protein. Wheeler DB, Zoncu R, Root DE, Sabatini DM, Sawyers CL. Science. 2015 Oct 9;350(6257):211-7. doi: 10.1126/science.aaa4903. Epub 2015 Sep 3. PubMed

Associated Plasmids

Release of Vesicular Stomatitis Virus Spike Protein G-Pseudotyped Lentivirus from the Host Cell Is Impaired upon Low-Density Lipoprotein Receptor Overexpression. Otahal A, Fuchs R, Al-Allaf FA, Blaas D. J Virol. 2015 Nov;89(22):11723-6. doi: 10.1128/JVI.01869-15. Epub 2015 Sep 2. PubMed
Use of genetically-encoded calcium indicators for live cell calcium imaging and localization in virus-infected cells. Perry JL, Ramachandran NK, Utama B, Hyser JM. Methods. 2015 Nov 15;90:28-38. doi: 10.1016/j.ymeth.2015.09.004. Epub 2015 Sep 3. PubMed
Transcriptome Profiling Reveals Degree of Variability in Induced Pluripotent Stem Cell Lines: Impact for Human Disease Modeling. Schuster J, Halvardson J, Pilar Lorenzo L, Ameur A, Sobol M, Raykova D, Anneren G, Feuk L, Dahl N. Cell Reprogram. 2015 Oct;17(5):327-37. doi: 10.1089/cell.2015.0009. Epub 2015 Sep 8. PubMed
The Interferon-induced Transmembrane Proteins, IFITM1, IFITM2, and IFITM3 Inhibit Hepatitis C Virus Entry. Narayana SK, Helbig KJ, McCartney EM, Eyre NS, Bull RA, Eltahla A, Lloyd AR, Beard MR. J Biol Chem. 2015 Oct 23;290(43):25946-59. doi: 10.1074/jbc.M115.657346. Epub 2015 Sep 9. PubMed
CRISPR/Cas9 System as an Agent for Eliminating Polyomavirus JC Infection. Wollebo HS, Bellizzi A, Kaminski R, Hu W, White MK, Khalili K. PLoS One. 2015 Sep 11;10(9):e0136046. doi: 10.1371/journal.pone.0136046. eCollection 2015. PubMed
Structural centrosome aberrations favor proliferation by abrogating microtubule-dependent tissue integrity of breast epithelial mammospheres. Schnerch D, Nigg EA. Oncogene. 2015 Sep 14. doi: 10.1038/onc.2015.332. PubMed
The TRAF-interacting protein (TRAIP) is a novel E2F target with peak expression in mitosis. Chapard C, Hohl D, Huber M. Oncotarget. 2015 Aug 28;6(25):20933-45. PubMed
Global Transcriptome Analysis Reveals That Poly(ADP-Ribose) Polymerase 1 Regulates Gene Expression through EZH2. Martin KA, Cesaroni M, Denny MF, Lupey LN, Tempera I. Mol Cell Biol. 2015 Dec;35(23):3934-44. doi: 10.1128/MCB.00635-15. Epub 2015 Sep 14. PubMed
Basal cells of the human airways acquire mesenchymal traits in idiopathic pulmonary fibrosis and in culture. Jonsdottir HR, Arason AJ, Palsson R, Franzdottir SR, Gudbjartsson T, Isaksson HJ, Gudmundsson G, Gudjonsson T, Magnusson MK. Lab Invest. 2015 Dec;95(12):1418-28. doi: 10.1038/labinvest.2015.114. Epub 2015 Sep 21. PubMed
Routes of Ca2+ Shuttling during Ca2+ Oscillations: FOCUS ON THE ROLE OF MITOCHONDRIAL Ca2+ HANDLING AND CYTOSOLIC Ca2+ BUFFERS. Pecze L, Blum W, Schwaller B. J Biol Chem. 2015 Nov 20;290(47):28214-30. doi: 10.1074/jbc.M115.663179. Epub 2015 Sep 22. PubMed
OTX2 is a therapeutic target for retinoblastoma and may function as a common factor between C-MYC, CRX, and phosphorylated RB pathways. Li J, Di C, Jing J, Di Q, Nakhla J, Adamson DC. Int J Oncol. 2015 Nov;47(5):1703-10. doi: 10.3892/ijo.2015.3179. Epub 2015 Sep 23. PubMed
LKB1 loss promotes endometrial cancer progression via CCL2-dependent macrophage recruitment. Pena CG, Nakada Y, Saatcioglu HD, Aloisio GM, Cuevas I, Zhang S, Miller DS, Lea JS, Wong KK, DeBerardinis RJ, Amelio AL, Brekken RA, Castrillon DH. J Clin Invest. 2015 Nov 2;125(11):4063-76. doi: 10.1172/JCI82152. Epub 2015 Sep 28. PubMed
EMMPRIN regulates tumor growth and metastasis by recruiting bone marrow-derived cells through paracrine signaling of SDF-1 and VEGF. Chen Y, Gou X, Kong DK, Wang X, Wang J, Chen Z, Huang C, Zhou J. Oncotarget. 2015 Oct 20;6(32):32575-85. doi: 10.18632/oncotarget.5331. PubMed
ZIC2-dependent OCT4 activation drives self-renewal of human liver cancer stem cells. Zhu P, Wang Y, He L, Huang G, Du Y, Zhang G, Yan X, Xia P, Ye B, Wang S, Hao L, Wu J, Fan Z. J Clin Invest. 2015 Oct 1;125(10):3795-808. doi: 10.1172/JCI81979. Epub 2015 Aug 31. PubMed
Differentiation-Dependent KLF4 Expression Promotes Lytic Epstein-Barr Virus Infection in Epithelial Cells. Nawandar DM, Wang A, Makielski K, Lee D, Ma S, Barlow E, Reusch J, Jiang R, Wille CK, Greenspan D, Greenspan JS, Mertz JE, Hutt-Fletcher L, Johannsen EC, Lambert PF, Kenney SC. PLoS Pathog. 2015 Oct 2;11(10):e1005195. doi: 10.1371/journal.ppat.1005195. eCollection 2015 Oct. PubMed
Succination is Increased on Select Proteins in the Brainstem of the NADH dehydrogenase (ubiquinone) Fe-S protein 4 (Ndufs4) Knockout Mouse, a Model of Leigh Syndrome. Piroli GG, Manuel AM, Clapper AC, Walla MD, Baatz JE, Palmiter RD, Quintana A, Frizzell N. Mol Cell Proteomics. 2016 Feb;15(2):445-61. doi: 10.1074/mcp.M115.051516. Epub 2015 Oct 8. PubMed
MFG-E8 Is Critical for Embryonic Stem Cell-Mediated T Cell Immunomodulation. Tan Y, AlKhamees B, Jia D, Li L, Couture JF, Figeys D, Jinushi M, Wang L. Stem Cell Reports. 2015 Nov 10;5(5):741-52. doi: 10.1016/j.stemcr.2015.09.005. Epub 2015 Oct 8. PubMed
Transcriptional repression by the HDAC4-RelB-p52 complex regulates multiple myeloma survival and growth. Vallabhapurapu SD, Noothi SK, Pullum DA, Lawrie CH, Pallapati R, Potluri V, Kuntzen C, Khan S, Plas DR, Orlowski RZ, Chesi M, Kuehl WM, Bergsagel PL, Karin M, Vallabhapurapu S. Nat Commun. 2015 Oct 12;6:8428. doi: 10.1038/ncomms9428. PubMed
Reliable and inexpensive expression of large, tagged, exogenous proteins in murine bone marrow-derived macrophages using a second generation lentiviral system. Miller MR, Blystone SD. J Biol Methods. 2015;2(3):e23. PubMed
MCL-1-independent mechanisms of synergy between dual PI3K/mTOR and BCL-2 inhibition in diffuse large B cell lymphoma. Lee JS, Tang SS, Ortiz V, Vo TT, Fruman DA. Oncotarget. 2015 Nov 3;6(34):35202-17. doi: 10.18632/oncotarget.6051. PubMed
Targeting of BCL2 Family Proteins with ABT-199 and Homoharringtonine Reveals BCL2- and MCL1-Dependent Subgroups of Diffuse Large B-Cell Lymphoma. Klanova M, Andera L, Brazina J, Svadlenka J, Benesova S, Soukup J, Prukova D, Vejmelkova D, Jaksa R, Helman K, Vockova P, Lateckova L, Molinsky J, Maswabi BC, Alam M, Kodet R, Pytlik R, Trneny M, Klener P. Clin Cancer Res. 2015 Oct 14. PubMed
The Effector Domain of MARCKS Is a Nuclear Localization Signal that Regulates Cellular PIP2 Levels and Nuclear PIP2 Localization. Rohrbach TD, Shah N, Jackson WP, Feeney EV, Scanlon S, Gish R, Khodadadi R, Hyde SO, Hicks PH, Anderson JC, Jarboe JS, Willey CD. PLoS One. 2015 Oct 15;10(10):e0140870. doi: 10.1371/journal.pone.0140870. eCollection 2015. PubMed
Knockdown of GLP-1 Receptors in Vagal Afferents Affects Normal Food Intake and Glycemia. Krieger JP, Arnold M, Pettersen KG, Lossel P, Langhans W, Lee SJ. Diabetes. 2016 Jan;65(1):34-43. doi: 10.2337/db15-0973. Epub 2015 Oct 15. PubMed
Targeting mitochondrial RNA polymerase in acute myeloid leukemia. Bralha FN, Liyanage SU, Hurren R, Wang X, Son MH, Fung TA, Chingcuanco FB, Tung AY, Andreazza AC, Psarianos P, Schimmer AD, Salmena L, Laposa RR. Oncotarget. 2015 Nov 10;6(35):37216-28. doi: 10.18632/oncotarget.6129. PubMed
Interferon Kappa Inhibits Human Papillomavirus 31 Transcription by Inducing Sp100 Proteins. Habiger C, Jager G, Walter M, Iftner T, Stubenrauch F. J Virol. 2015 Oct 21;90(2):694-704. doi: 10.1128/JVI.02137-15. PubMed
DECKO: Single-oligo, dual-CRISPR deletion of genomic elements including long non-coding RNAs. Aparicio-Prat E, Arnan C, Sala I, Bosch N, Guigo R, Johnson R. BMC Genomics. 2015 Oct 23;16(1):846. doi: 10.1186/s12864-015-2086-z. PubMed

Associated Plasmids

Highly specific epigenome editing by CRISPR-Cas9 repressors for silencing of distal regulatory elements. Thakore PI, D'Ippolito AM, Song L, Safi A, Shivakumar NK, Kabadi AM, Reddy TE, Crawford GE, Gersbach CA. Nat Methods. 2015 Dec;12(12):1143-9. doi: 10.1038/nmeth.3630. Epub 2015 Oct 26. PubMed

Associated Plasmids

Skeletal Muscle Phospholipid Metabolism Regulates Insulin Sensitivity and Contractile Function. Funai K, Lodhi IJ, Spears LD, Yin L, Song H, Klein S, Semenkovich CF. Diabetes. 2016 Feb;65(2):358-70. doi: 10.2337/db15-0659. Epub 2015 Oct 28. PubMed
Identification of short-form RON as a novel intrinsic resistance mechanism for anti-MET therapy in MET-positive gastric cancer. Wu Z, Zhang Z, Ge X, Lin Y, Dai C, Chang J, Liu X, Geng R, Wang C, Chen H, Sun M, Guo W, Li J. Oncotarget. 2015 Dec 1;6(38):40519-34. doi: 10.18632/oncotarget.5816. PubMed
Combinatorial BTK and MALT1 inhibition augments killing of CD79 mutant diffuse large B cell lymphoma. Nagel D, Bognar M, Eitelhuber AC, Kutzner K, Vincendeau M, Krappmann D. Oncotarget. 2015 Dec 8;6(39):42232-42. doi: 10.18632/oncotarget.6273. PubMed
The leukodystrophy protein FAM126A (hyccin) regulates PtdIns(4)P synthesis at the plasma membrane. Baskin JM, Wu X, Christiano R, Oh MS, Schauder CM, Gazzerro E, Messa M, Baldassari S, Assereto S, Biancheri R, Zara F, Minetti C, Raimondi A, Simons M, Walther TC, Reinisch KM, De Camilli P. Nat Cell Biol. 2016 Jan;18(1):132-8. doi: 10.1038/ncb3271. Epub 2015 Nov 16. PubMed
Fat4 suppression induces Yap translocation accounting for the promoted proliferation and migration of gastric cancer cells. Ma L, Cui J, Xi H, Bian S, Wei B, Chen L. Cancer Biol Ther. 2016;17(1):36-47. doi: 10.1080/15384047.2015.1108488. PubMed
ETS family transcriptional regulators drive chromatin dynamics and malignancy in squamous cell carcinomas. Yang H, Schramek D, Adam RC, Keyes BE, Wang P, Zheng D, Fuchs E. Elife. 2015 Nov 21;4. pii: e10870. doi: 10.7554/eLife.10870. PubMed
Targeting p300 Addiction in CBP-Deficient Cancers Causes Synthetic Lethality by Apoptotic Cell Death due to Abrogation of MYC Expression. Ogiwara H, Sasaki M, Mitachi T, Oike T, Higuchi S, Tominaga Y, Kohno T. Cancer Discov. 2016 Apr;6(4):430-45. doi: 10.1158/2159-8290.CD-15-0754. Epub 2015 Nov 24. PubMed
A PCR-Based Method to Construct Lentiviral Vector Expressing Double Tough Decoy for miRNA Inhibition. Qiu H, Zhong J, Luo L, Liu N, Kang K, Qu J, Peng W, Gou D. PLoS One. 2015 Dec 1;10(12):e0143864. doi: 10.1371/journal.pone.0143864. eCollection 2015. PubMed
PTEN deficiency reprogrammes human neural stem cells towards a glioblastoma stem cell-like phenotype. Duan S, Yuan G, Liu X, Ren R, Li J, Zhang W, Wu J, Xu X, Fu L, Li Y, Yang J, Zhang W, Bai R, Yi F, Suzuki K, Gao H, Esteban CR, Zhang C, Izpisua Belmonte JC, Chen Z, Wang X, Jiang T, Qu J, Tang F, Liu GH. Nat Commun. 2015 Dec 3;6:10068. doi: 10.1038/ncomms10068. PubMed
alpha-synuclein interacts with SOD1 and promotes its oligomerization. Helferich AM, Ruf WP, Grozdanov V, Freischmidt A, Feiler MS, Zondler L, Ludolph AC, McLean PJ, Weishaupt JH, Danzer KM. Mol Neurodegener. 2015 Dec 8;10:66. doi: 10.1186/s13024-015-0062-3. PubMed
The Notch and Wnt pathways regulate stemness and differentiation in human fallopian tube organoids. Kessler M, Hoffmann K, Brinkmann V, Thieck O, Jackisch S, Toelle B, Berger H, Mollenkopf HJ, Mangler M, Sehouli J, Fotopoulou C, Meyer TF. Nat Commun. 2015 Dec 8;6:8989. doi: 10.1038/ncomms9989. PubMed
Deregulated KLF4 Expression in Myeloid Leukemias Alters Cell Proliferation and Differentiation through MicroRNA and Gene Targets. Morris VA, Cummings CL, Korb B, Boaglio S, Oehler VG. Mol Cell Biol. 2015 Dec 7;36(4):559-73. doi: 10.1128/MCB.00712-15. PubMed
A Common CCK-B Receptor Intronic Variant in Pancreatic Adenocarcinoma in a Hungarian Cohort. Balazs A, Nemeth BC, Ordog B, Hegyi E, Hritz I, Czako L, Czimmer J, Godi S, Csiszko A, Rakonczay Z Jr, Parniczky A, Izbeki F, Halasz A, Kahan Z, Hegyi P, Sahin-Toth M. Pancreas. 2016 Apr;45(4):541-5. doi: 10.1097/MPA.0000000000000539. PubMed
Characterization of a Novel Human-Specific STING Agonist that Elicits Antiviral Activity Against Emerging Alphaviruses. Sali TM, Pryke KM, Abraham J, Liu A, Archer I, Broeckel R, Staverosky JA, Smith JL, Al-Shammari A, Amsler L, Sheridan K, Nilsen A, Streblow DN, DeFilippis VR. PLoS Pathog. 2015 Dec 8;11(12):e1005324. doi: 10.1371/journal.ppat.1005324. eCollection 2015 Dec. PubMed
A new design of a lentiviral shRNA vector with inducible co-expression of ARGONAUTE 2 for enhancing gene silencing efficiency. He J, Huang L, Qiu H, Li J, Luo L, Li Y, Tian S, Kang K, Luo J, Liu L, Gou D. Cell Biosci. 2015 Dec 8;5:67. doi: 10.1186/s13578-015-0058-2. eCollection 2015. PubMed
A Gene Expression Signature Associated with Overall Survival in Patients with Hepatocellular Carcinoma Suggests a New Treatment Strategy. Gillet JP, Andersen JB, Madigan JP, Varma S, Bagni RK, Powell K, Burgan WE, Wu CP, Calcagno AM, Ambudkar SV, Thorgeirsson SS, Gottesman MM. Mol Pharmacol. 2016 Feb;89(2):263-72. doi: 10.1124/mol.115.101360. Epub 2015 Dec 14. PubMed
TBX3 Knockdown Decreases Reprogramming Efficiency of Human Cells. Klingenstein M, Raab S, Achberger K, Kleger A, Liebau S, Linta L. Stem Cells Int. 2016;2016:6759343. doi: 10.1155/2016/6759343. Epub 2015 Nov 30. PubMed
Upregulation of EMMPRIN (OX47) in Rat Dorsal Root Ganglion Contributes to the Development of Mechanical Allodynia after Nerve Injury. Wang Q, Sun Y, Ren Y, Gao Y, Tian L, Liu Y, Pu Y, Gou X, Chen Y, Lu Y. Neural Plast. 2015;2015:249756. doi: 10.1155/2015/249756. Epub 2015 Nov 30. PubMed
Manipulation of the N-terminal sequence of the Borna disease virus X protein improves its mitochondrial targeting and neuroprotective potential. Ferre CA, Davezac N, Thouard A, Peyrin JM, Belenguer P, Miquel MC, Gonzalez-Dunia D, Szelechowski M. FASEB J. 2015 Dec 23. pii: fj.15-279620. PubMed
Ebola virus mediated infectivity is restricted in canine and feline cells. Han Z, Bart SM, Ruthel G, Vande Burgt NH, Haines KM, Volk SW, Vite CH, Freedman BD, Bates P, Harty RN. Vet Microbiol. 2016 Jan 15;182:102-7. doi: 10.1016/j.vetmic.2015.11.011. Epub 2015 Nov 17. PubMed
Genome-Wide Transcriptional Regulation Mediated by Biochemically Distinct SWI/SNF Complexes. Raab JR, Resnick S, Magnuson T. PLoS Genet. 2015 Dec 30;11(12):e1005748. doi: 10.1371/journal.pgen.1005748. eCollection 2015 Dec. PubMed
NIPBL Controls RNA Biogenesis to Prevent Activation of the Stress Kinase PKR. Yuen KC, Xu B, Krantz ID, Gerton JL. Cell Rep. 2016 Jan 5;14(1):93-102. doi: 10.1016/j.celrep.2015.12.012. Epub 2015 Dec 24. PubMed
The Polymerase Activity of Mammalian DNA Pol zeta Is Specifically Required for Cell and Embryonic Viability. Lange SS, Tomida J, Boulware KS, Bhetawal S, Wood RD. PLoS Genet. 2016 Jan 4;12(1):e1005759. doi: 10.1371/journal.pgen.1005759. eCollection 2016 Jan. PubMed
Inhibition of Canonical NF-kappaB Signaling by a Small Molecule Targeting NEMO-Ubiquitin Interaction. Vincendeau M, Hadian K, Messias AC, Brenke JK, Halander J, Griesbach R, Greczmiel U, Bertossi A, Stehle R, Nagel D, Demski K, Velvarska H, Niessing D, Geerlof A, Sattler M, Krappmann D. Sci Rep. 2016 Jan 7;6:18934. doi: 10.1038/srep18934. PubMed
Research Resource: Genetic Labeling of Human Islet Alpha Cells. Pauerstein PT, Park KM, Peiris HS, Wang J, Kim SK. Mol Endocrinol. 2016 Feb;30(2):248-53. doi: 10.1210/me.2015-1220. Epub 2016 Jan 8. PubMed
Haploinsufficiency of BAZ1B contributes to Williams syndrome through transcriptional dysregulation of neurodevelopmental pathways. Lalli MA, Jang J, Park JC, Wang Y, Guzman E, Zhou H, Audouard M, Bridges D, Tovar KR, Papuc SM, Tutulan-Cunita AC, Huang Y, Budisteanu M, Arghir A, Kosik KS. Hum Mol Genet. 2016 Jan 10. pii: ddw010. PubMed
Epithelial-to-Mesenchymal Transition of RPE Cells In Vitro Confers Increased beta1,6-N-Glycosylation and Increased Susceptibility to Galectin-3 Binding. Priglinger CS, Obermann J, Szober CM, Merl-Pham J, Ohmayer U, Behler J, Gruhn F, Kreutzer TC, Wertheimer C, Geerlof A, Priglinger SG, Hauck SM. PLoS One. 2016 Jan 13;11(1):e0146887. doi: 10.1371/journal.pone.0146887. eCollection 2016. PubMed
Selection-free gene repair after adenoviral vector transduction of designer nucleases: rescue of dystrophin synthesis in DMD muscle cell populations. Maggio I, Stefanucci L, Janssen JM, Liu J, Chen X, Mouly V, Goncalves MA. Nucleic Acids Res. 2016 Jan 13. pii: gkv1540. PubMed
Disease causing mutations in inverted formin 2 regulate its binding to G-actin, F-actin capping protein (CapZ alpha-1) and profilin 2. Rollason R, Wherlock M, Heath JA, Heesom KJ, Saleem MA, Welsh GI. Biosci Rep. 2016 Jan 13;36(1):e00302. doi: 10.1042/BSR20150252. PubMed
Human pluripotent stem cell culture density modulates YAP signaling. Hsiao C, Lampe M, Nillasithanukroh S, Han W, Lian X, Palecek SP. Biotechnol J. 2016 Jan 14. doi: 10.1002/biot.201500374. PubMed
Oncogenic CARMA1 couples NF-kappaB and beta-catenin signaling in diffuse large B-cell lymphomas. Bognar MK, Vincendeau M, Erdmann T, Seeholzer T, Grau M, Linnemann JR, Ruland J, Scheel CH, Lenz P, Ott G, Lenz G, Hauck SM, Krappmann D. Oncogene. 2016 Jan 18. doi: 10.1038/onc.2015.493. PubMed
Live imaging of microtubule dynamics in organotypic hippocampal slice cultures. Schatzle P, Kapitein LC, Hoogenraad CC. Methods Cell Biol. 2016;131:107-26. doi: 10.1016/bs.mcb.2015.06.006. Epub 2015 Sep 3. PubMed
Induced Pluripotent Stem Cells of Microtus levis x Microtus arvalis Vole Hybrids: Conditions Necessary for Their Generation and Self-Renewal. Grigor'eva EV, Shevchenko AI, Medvedev SP, Mazurok NA, Zhelezova AI, Zakian SM. Acta Naturae. 2015 Oct-Dec;7(4):56-69. PubMed
TFEB and TFE3 are novel components of the integrated stress response. Martina JA, Diab HI, Brady OA, Puertollano R. EMBO J. 2016 Mar 1;35(5):479-95. doi: 10.15252/embj.201593428. Epub 2016 Jan 25. PubMed
Mitochondrial genome variations and functional characterization in Han Chinese families with schizophrenia. Bi R, Tang J, Zhang W, Li X, Chen SY, Yu D, Chen X, Yao YG. Schizophr Res. 2016 Jan 25. pii: S0920-9964(16)30011-1. doi: 10.1016/j.schres.2016.01.011. PubMed
Staufen1 Regulates Multiple Alternative Splicing Events either Positively or Negatively in DM1 Indicating Its Role as a Disease Modifier. Bondy-Chorney E, Crawford Parks TE, Ravel-Chapuis A, Klinck R, Rocheleau L, Pelchat M, Chabot B, Jasmin BJ, Cote J. PLoS Genet. 2016 Jan 29;12(1):e1005827. doi: 10.1371/journal.pgen.1005827. eCollection 2016 Jan. PubMed
Agonist-induced activation of histamine H3 receptor signals to extracellular signal-regulated kinases 1 and 2 through PKC-, PLD-, and EGFR-dependent mechanisms. Lai X, Ye L, Liao Y, Jin L, Ma Q, Lu B, Sun Y, Shi Y, Zhou N. J Neurochem. 2016 Apr;137(2):200-15. doi: 10.1111/jnc.13559. Epub 2016 Mar 10. PubMed
Opposing Roles of JNK and p38 in Lymphangiogenesis in Melanoma. Puujalka E, Heinz M, Hoesel B, Friedl P, Schweighofer B, Wenzina J, Pirker C, Schmid JA, Loewe R, Wagner EF, Berger W, Petzelbauer P. J Invest Dermatol. 2016 May;136(5):967-77. doi: 10.1016/j.jid.2016.01.020. Epub 2016 Jan 30. PubMed
WNT/beta-catenin signaling mediates human neural crest induction via a pre-neural border intermediate. Leung AW, Murdoch B, Salem AF, Prasad MS, Gomez GA, Garcia-Castro MI. Development. 2016 Feb 1;143(3):398-410. doi: 10.1242/dev.130849. PubMed
Regulation of Nuclear Receptor Nur77 by miR-124. Tenga A, Beard JA, Takwi A, Wang YM, Chen T. PLoS One. 2016 Feb 3;11(2):e0148433. doi: 10.1371/journal.pone.0148433. eCollection 2016. PubMed
MeCP2 SUMOylation rescues Mecp2-mutant-induced behavioural deficits in a mouse model of Rett syndrome. Tai DJ, Liu YC, Hsu WL, Ma YL, Cheng SJ, Liu SY, Lee EH. Nat Commun. 2016 Feb 4;7:10552. doi: 10.1038/ncomms10552. PubMed
Microtubules Inhibit E-Cadherin Adhesive Activity by Maintaining Phosphorylated p120-Catenin in a Colon Carcinoma Cell Model. Maiden SL, Petrova YI, Gumbiner BM. PLoS One. 2016 Feb 4;11(2):e0148574. doi: 10.1371/journal.pone.0148574. eCollection 2016. PubMed
HDAC7 inhibition resets STAT3 tumorigenic activity in human glioblastoma independently of EGFR and PTEN: new opportunities for selected targeted therapies. Peixoto P, Blomme A, Costanza B, Ronca R, Rezzola S, Palacios AP, Schoysman L, Boutry S, Goffart N, Peulen O, Maris P, Di Valentin E, Hennequiere V, Bianchi E, Henry A, Meunier P, Rogister B, Muller RN, Delvenne P, Bellahcene A, Castronovo V, Turtoi A. Oncogene. 2016 Aug 25;35(34):4481-94. doi: 10.1038/onc.2015.506. Epub 2016 Feb 8. PubMed
Lysophosphatidic acid activates Arf6 to promote the mesenchymal malignancy of renal cancer. Hashimoto S, Mikami S, Sugino H, Yoshikawa A, Hashimoto A, Onodera Y, Furukawa S, Handa H, Oikawa T, Okada Y, Oya M, Sabe H. Nat Commun. 2016 Feb 8;7:10656. doi: 10.1038/ncomms10656. PubMed
Feedback activation of neurofibromin terminates growth factor-induced Ras activation. Hennig A, Markwart R, Wolff K, Schubert K, Cui Y, Prior IA, Esparza-Franco MA, Ladds G, Rubio I. Cell Commun Signal. 2016 Feb 9;14:5. doi: 10.1186/s12964-016-0128-z. PubMed
The Endoplasmic Reticulum Chaperone Calnexin Is a NADPH Oxidase NOX4 Interacting Protein. Prior KK, Wittig I, Leisegang MS, Groenendyk J, Weissmann N, Michalak M, Jansen-Durr P, Shah AM, Brandes RP. J Biol Chem. 2016 Mar 25;291(13):7045-59. doi: 10.1074/jbc.M115.710772. Epub 2016 Feb 9. PubMed
The Sigma-2 Receptor and Progesterone Receptor Membrane Component 1 are Different Binding Sites Derived From Independent Genes. Chu UB, Mavlyutov TA, Chu ML, Yang H, Schulman A, Mesangeau C, McCurdy CR, Guo LW, Ruoho AE. EBioMedicine. 2015 Oct 19;2(11):1806-13. doi: 10.1016/j.ebiom.2015.10.017. eCollection 2015 Nov. PubMed
GemC1 controls multiciliogenesis in the airway epithelium. Arbi M, Pefani DE, Kyrousi C, Lalioti ME, Kalogeropoulou A, Papanastasiou AD, Taraviras S, Lygerou Z. EMBO Rep. 2016 Mar;17(3):400-13. doi: 10.15252/embr.201540882. Epub 2016 Feb 4. PubMed
Progesterone receptor (PR) polyproline domain (PPD) mediates inhibition of epidermal growth factor receptor (EGFR) signaling in non-small cell lung cancer cells. Kawprasertsri S, Pietras RJ, Marquez-Garban DC, Boonyaratanakornkit V. Cancer Lett. 2016 May 1;374(2):279-91. doi: 10.1016/j.canlet.2016.02.014. Epub 2016 Feb 15. PubMed
Specifically modified Env immunogens activate B-cell precursors of broadly neutralizing HIV-1 antibodies in transgenic mice. McGuire AT, Gray MD, Dosenovic P, Gitlin AD, Freund NT, Petersen J, Correnti C, Johnsen W, Kegel R, Stuart AB, Glenn J, Seaman MS, Schief WR, Strong RK, Nussenzweig MC, Stamatatos L. Nat Commun. 2016 Feb 24;7:10618. doi: 10.1038/ncomms10618. PubMed
Defining functional classes of Barth syndrome mutation in humans. Lu YW, Galbraith L, Herndon JD, Lu YL, Pras-Raves M, Vervaart M, Van Kampen A, Luyf A, Koehler CM, McCaffery JM, Gottlieb E, Vaz FM, Claypool SM. Hum Mol Genet. 2016 May 1;25(9):1754-70. doi: 10.1093/hmg/ddw046. Epub 2016 Feb 16. PubMed
GATA3-dependent cellular reprogramming requires activation-domain dependent recruitment of a chromatin remodeler. Takaku M, Grimm SA, Shimbo T, Perera L, Menafra R, Stunnenberg HG, Archer TK, Machida S, Kurumizaka H, Wade PA. Genome Biol. 2016 Feb 27;17:36. doi: 10.1186/s13059-016-0897-0. PubMed
The retrovirus HTLV-1 inserts an ectopic CTCF-binding site into the human genome. Satou Y, Miyazato P, Ishihara K, Yaguchi H, Melamed A, Miura M, Fukuda A, Nosaka K, Watanabe T, Rowan AG, Nakao M, Bangham CR. Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):3054-9. doi: 10.1073/pnas.1423199113. Epub 2016 Feb 29. PubMed
Radiosensitization by PARP Inhibition in DNA Repair Proficient and Deficient Tumor Cells: Proliferative Recovery in Senescent Cells. Alotaibi M, Sharma K, Saleh T, Povirk LF, Hendrickson EA, Gewirtz DA. Radiat Res. 2016 Mar;185(3):229-45. doi: 10.1667/RR14202.1. Epub 2016 Mar 2. PubMed
LKB1 inhibits the proliferation of gastric cancer cells by suppressing the nuclear translocation of Yap and beta-catenin. Ma LG, Bian SB, Cui JX, Xi HQ, Zhang KC, Qin HZ, Zhu XM, Chen L. Int J Mol Med. 2016 Apr;37(4):1039-48. doi: 10.3892/ijmm.2016.2494. Epub 2016 Feb 19. PubMed
An integrin beta4-EGFR unit promotes hepatocellular carcinoma lung metastases by enhancing anchorage independence through activation of FAK-AKT pathway. Leng C, Zhang ZG, Chen WX, Luo HP, Song J, Dong W, Zhu XR, Chen XP, Liang HF, Zhang BX. Cancer Lett. 2016 Jun 28;376(1):188-96. doi: 10.1016/j.canlet.2016.03.023. Epub 2016 Mar 17. PubMed
Ultrahigh-throughput Generation and Characterization of Cellular Aggregates in Laser-ablated Microwells of Poly(dimethylsiloxane). Albritton JL, Roybal JD, Paulsen SJ, Calafat N, Flores-Zaher JA, Farach-Carson MC, Gibbons DL, Miller JS. RSC Adv. 2016 Jan 1;6(11):8980-8991. Epub 2016 Jan 12. PubMed
Enhancing DPYSL3 gene expression via a promoter-targeted small activating RNA approach suppresses cancer cell motility and metastasis. Li C, Jiang W, Hu Q, Li LC, Dong L, Chen R, Zhang Y, Tang Y, Thrasher JB, Liu CB, Li B. Oncotarget. 2016 Mar 23. doi: 10.18632/oncotarget.8290. PubMed
PCGF2 negatively regulates arsenic trioxide-induced PML-RARA protein degradation via UBE2I inhibition in NB4 cells. Jo S, Lee YL, Kim S, Lee H, Chung H. Biochim Biophys Acta. 2016 Jul;1863(7 Pt A):1499-509. doi: 10.1016/j.bbamcr.2016.03.019. Epub 2016 Mar 24. PubMed
P53- and mevalonate pathway-driven malignancies require Arf6 for metastasis and drug resistance. Hashimoto A, Oikawa T, Hashimoto S, Sugino H, Yoshikawa A, Otsuka Y, Handa H, Onodera Y, Nam JM, Oneyama C, Okada M, Fukuda M, Sabe H. J Cell Biol. 2016 Apr 11;213(1):81-95. doi: 10.1083/jcb.201510002. Epub 2016 Apr 4. PubMed
Complex Regulation Pattern of IRF3 Activation Revealed by a Novel Dimerization Reporter System. Wang Z, Ji J, Peng D, Ma F, Cheng G, Qin FX. J Immunol. 2016 May 15;196(10):4322-30. doi: 10.4049/jimmunol.1502458. Epub 2016 Apr 4. PubMed
Circadian factors BMAL1 and RORalpha control HIF-1alpha transcriptional activity in nucleus pulposus cells: implications in maintenance of intervertebral disc health. Suyama K, Silagi ES, Choi H, Sakabe K, Mochida J, Shapiro IM, Risbud MV. Oncotarget. 2016 Mar 31. doi: 10.18632/oncotarget.8521. PubMed
Large-scale production of megakaryocytes from human pluripotent stem cells by chemically defined forward programming. Moreau T, Evans AL, Vasquez L, Tijssen MR, Yan Y, Trotter MW, Howard D, Colzani M, Arumugam M, Wu WH, Dalby A, Lampela R, Bouet G, Hobbs CM, Pask DC, Payne H, Ponomaryov T, Brill A, Soranzo N, Ouwehand WH, Pedersen RA, Ghevaert C. Nat Commun. 2016 Apr 7;7:11208. doi: 10.1038/ncomms11208. PubMed
Infection of epithelial cells with Chlamydia trachomatis inhibits TNF-induced apoptosis at the level of receptor internalisation while leaving non-apoptotic TNF-signalling intact. Kontchou CW, Tzivelekidis T, Gentle IE, Hacker G. Cell Microbiol. 2016 Apr 8. doi: 10.1111/cmi.12598. PubMed
Thyroid follicle development requires Smad1/5- and endothelial cell-dependent basement membrane assembly. Villacorte M, Delmarcelle AS, Lernoux M, Bouquet M, Lemoine P, Bolsee J, Umans L, de Sousa Lopes SC, Van Der Smissen P, Sasaki T, Bommer G, Henriet P, Refetoff S, Lemaigre FP, Zwijsen A, Courtoy PJ, Pierreux CE. Development. 2016 Jun 1;143(11):1958-70. doi: 10.1242/dev.134171. Epub 2016 Apr 11. PubMed
ExtraPEG: A Polyethylene Glycol-Based Method for Enrichment of Extracellular Vesicles. Rider MA, Hurwitz SN, Meckes DG Jr. Sci Rep. 2016 Apr 12;6:23978. doi: 10.1038/srep23978. PubMed
Activation of PTHrP-cAMP-CREB1 signaling following p53 loss is essential for osteosarcoma initiation and maintenance. Walia MK, Ho PM, Taylor S, Ng AJ, Gupte A, Chalk AM, Zannettino AC, Martin TJ, Walkley CR. Elife. 2016 Apr 12;5. pii: e13446. doi: 10.7554/eLife.13446. PubMed
The Herpes Simplex Virus Virion Host Shutoff Protein Enhances Translation of Viral True Late mRNAs Independently of Suppressing Protein Kinase R and Stress Granule Formation. Dauber B, Poon D, Dos Santos T, Duguay BA, Mehta N, Saffran HA, Smiley JR. J Virol. 2016 Jun 10;90(13):6049-57. doi: 10.1128/JVI.03180-15. Print 2016 Jul 1. PubMed
Enhanced direct conversion of fibroblasts into hepatocyte-like cells by Kdm2b. Zakikhan K, Pournasr B, Nassiri-Asl M, Baharvand H. Biochem Biophys Res Commun. 2016 May 20;474(1):97-103. doi: 10.1016/j.bbrc.2016.04.076. Epub 2016 Apr 19. PubMed
Colorectal cancer cells display chaperone dependency for the unconventional prefoldin URI1. Lipinski KA, Britschgi C, Schrader K, Christinat Y, Frischknecht L, Krek W. Oncotarget. 2016 May 17;7(20):29635-47. doi: 10.18632/oncotarget.8816. PubMed
A convenient and effective strategy for the enrichment of tumor-initiating cell properties in prostate cancer cells. Zhang Y, Huang Y, Jin Z, Li X, Li B, Xu P, Huang P, Liu C. Tumour Biol. 2016 Apr 25. PubMed
An essential role for Grk2 in Hedgehog signalling downstream of Smoothened. Zhao Z, Lee RT, Pusapati GV, Iyu A, Rohatgi R, Ingham PW. EMBO Rep. 2016 May;17(5):739-52. doi: 10.15252/embr.201541532. Epub 2016 Apr 4. PubMed
The orphan nuclear receptor NR4A2 is part of a p53-microRNA-34 network. Beard JA, Tenga A, Hills J, Hoyer JD, Cherian MT, Wang YD, Chen T. Sci Rep. 2016 Apr 28;6:25108. doi: 10.1038/srep25108. PubMed
Methods for Efficient Elimination of Mitochondrial DNA from Cultured Cells. Spadafora D, Kozhukhar N, Chouljenko VN, Kousoulas KG, Alexeyev MF. PLoS One. 2016 May 2;11(5):e0154684. doi: 10.1371/journal.pone.0154684. eCollection 2016. PubMed

Associated Plasmids

Deletion of inositol hexakisphosphate kinase 1 (IP6K1) reduces cell migration and invasion, conferring protection from aerodigestive tract carcinoma in mice. Jadav RS, Kumar D, Buwa N, Ganguli S, Thampatty SR, Balasubramanian N, Bhandari R. Cell Signal. 2016 Aug;28(8):1124-36. doi: 10.1016/j.cellsig.2016.04.011. Epub 2016 Apr 30. PubMed
TET2 Regulates Mast Cell Differentiation and Proliferation through Catalytic and Non-catalytic Activities. Montagner S, Leoni C, Emming S, Della Chiara G, Balestrieri C, Barozzi I, Piccolo V, Togher S, Ko M, Rao A, Natoli G, Monticelli S. Cell Rep. 2016 May 17;15(7):1566-79. doi: 10.1016/j.celrep.2016.04.044. Epub 2016 May 5. PubMed

Associated Plasmids

The three Type 2A protein phosphatases, PP2Ac, PP4c and PP6c, are differentially regulated by Alpha4. LeNoue-Newton ML, Wadzinski BE, Spiller BW. Biochem Biophys Res Commun. 2016 Jun 17;475(1):64-9. doi: 10.1016/j.bbrc.2016.05.036. Epub 2016 May 8. PubMed
TFEB and TFE3 cooperate in the regulation of the innate immune response in activated macrophages. Pastore N, Brady OA, Diab HI, Martina JA, Sun L, Huynh T, Lim JA, Zare H, Raben N, Ballabio A, Puertollano R. Autophagy. 2016 May 12:1-19. PubMed
Targeting by AutophaGy proteins (TAG): Targeting of IFNG-inducible GTPases to membranes by the LC3 conjugation system of autophagy. Park S, Choi J, Biering SB, Dominici E, Williams LE, Hwang S. Autophagy. 2016 Jul 2;12(7):1153-67. doi: 10.1080/15548627.2016.1178447. Epub 2016 May 12. PubMed
The antitumor toxin CD437 is a direct inhibitor of DNA polymerase alpha. Han T, Goralski M, Capota E, Padrick SB, Kim J, Xie Y, Nijhawan D. Nat Chem Biol. 2016 Jul;12(7):511-5. doi: 10.1038/nchembio.2082. Epub 2016 May 16. PubMed
ISPD produces CDP-ribitol used by FKTN and FKRP to transfer ribitol phosphate onto alpha-dystroglycan. Gerin I, Ury B, Breloy I, Bouchet-Seraphin C, Bolsee J, Halbout M, Graff J, Vertommen D, Muccioli GG, Seta N, Cuisset JM, Dabaj I, Quijano-Roy S, Grahn A, Van Schaftingen E, Bommer GT. Nat Commun. 2016 May 19;7:11534. doi: 10.1038/ncomms11534. PubMed
Opposing Regulation of the EGF Receptor: A Molecular Switch Controlling Cytomegalovirus Latency and Replication. Buehler J, Zeltzer S, Reitsma J, Petrucelli A, Umashankar M, Rak M, Zagallo P, Schroeder J, Terhune S, Goodrum F. PLoS Pathog. 2016 May 24;12(5):e1005655. doi: 10.1371/journal.ppat.1005655. eCollection 2016 May. PubMed
Integrin alphavbeta3 enhances beta-catenin signaling in acute myeloid leukemia harboring Fms-like tyrosine kinase-3 internal tandem duplication mutations: implications for microenvironment influence on sorafenib sensitivity. Yi H, Zeng D, Shen Z, Liao J, Wang X, Liu Y, Zhang X, Kong P. Oncotarget. 2016 Jun 28;7(26):40387-40397. doi: 10.18632/oncotarget.9617. PubMed
A C-terminally truncated mouse Best3 splice variant targets and alters the ion balance in lysosome-endosome hybrids and the endoplasmic reticulum. Wu L, Sun Y, Ma L, Zhu J, Zhang B, Pan Q, Li Y, Liu H, Diao A, Li Y. Sci Rep. 2016 Jun 6;6:27332. doi: 10.1038/srep27332. PubMed
Atg7 suppression enhances chemotherapeutic agent sensitivity and overcomes stroma-mediated chemoresistance in acute myeloid leukemia. Piya S, Kornblau SM, Ruvolo VR, Mu H, Ruvolo PP, McQueen T, Davis RE, Hail N Jr, Kantarjian H, Andreeff M, Borthakur G. Blood. 2016 Jun 7. pii: blood-2016-01-692244. PubMed
Probing the impact of chromatin conformation on genome editing tools. Chen X, Rinsma M, Janssen JM, Liu J, Maggio I, Goncalves MA. Nucleic Acids Res. 2016 Jun 8. pii: gkw524. PubMed
Co-repressor CBFA2T2 regulates pluripotency and germline development. Tu S, Narendra V, Yamaji M, Vidal SE, Rojas LA, Wang X, Kim SY, Garcia BA, Tuschl T, Stadtfeld M, Reinberg D. Nature. 2016 Jun 8;534(7607):387-90. doi: 10.1038/nature18004. PubMed

Associated Plasmids

Cell-death-inducing DFFA-like Effector B Contributes to the Assembly of Hepatitis C Virus (HCV) Particles and Interacts with HCV NS5A. Cai H, Yao W, Li L, Li X, Hu L, Mai R, Peng T. Sci Rep. 2016 Jun 10;6:27778. doi: 10.1038/srep27778. PubMed
TMEM16F Regulates Baseline Phosphatidylserine Exposure and Cell Viability in Human Embryonic Kidney Cells. Schenk LK, Schulze U, Henke S, Weide T, Pavenstadt H. Cell Physiol Biochem. 2016;38(6):2452-63. doi: 10.1159/000445596. Epub 2016 Jun 13. PubMed
N-cadherin is Key to Expression of the Nucleus Pulposus Cell Phenotype under Selective Substrate Culture Conditions. Hwang PY, Jing L, Chen J, Lim FL, Tang R, Choi H, Cheung KM, Risbud MV, Gersbach CA, Guilak F, Leung VY, Setton LA. Sci Rep. 2016 Jun 13;6:28038. doi: 10.1038/srep28038. PubMed
Suppression of Spleen Tyrosine Kinase (Syk) by Histone Deacetylation Promotes, Whereas BAY61-3606, a Synthetic Syk Inhibitor Abrogates Colonocyte Apoptosis by ERK Activation. Dasgupta N, Thakur BK, Ta A, Dutta P, Das S. J Cell Biochem. 2016 Jun 13. doi: 10.1002/jcb.25625. PubMed
Autocrine Complement Inhibits IL10-Dependent T-Cell Mediated Antitumor Immunity to Promote Tumor Progression. Wang Y, Sun SN, Liu Q, Yu YY, Guo J, Wang K, Xing BC, Zheng QF, Campa MJ, Patz EF, Li SY, He YW. Cancer Discov. 2016 Jun 13. pii: CD-15-1412. PubMed
MicroRNA-181b inhibits thrombin-mediated endothelial activation and arterial thrombosis by targeting caspase recruitment domain family member 10. Lin J, He S, Sun X, Franck G, Deng Y, Yang D, Haemmig S, Wara AK, Icli B, Li D, Feinberg MW. FASEB J. 2016 Jun 13. pii: fj.201500163R. PubMed
Preventing Plasmon Coupling between Gold Nanorods Improves the Sensitivity of Photoacoustic Detection of Labeled Stem Cells in Vivo. Comenge J, Fragueiro O, Sharkey J, Taylor A, Held M, Burton NC, Park BK, Wilm B, Murray P, Brust M, Levy R. ACS Nano. 2016 Jul 26;10(7):7106-16. doi: 10.1021/acsnano.6b03246. Epub 2016 Jun 20. PubMed
AMPK-SKP2-CARM1 signalling cascade in transcriptional regulation of autophagy. Shin HR, Kim H, Oh S, Lee JG, Kee M, Ko HJ, Kweon MN, Won KJ, Baek SH. Nature. 2016 Jun 15. doi: 10.1038/nature18014. PubMed

Associated Plasmids

Autophagy regulates spermatid differentiation via degradation of PDLIM1. Shang Y, Wang H, Jia P, Zhao H, Liu C, Liu W, Song Z, Xu Z, Yang L, Wang Y, Li W. Autophagy. 2016 Sep;12(9):1575-92. doi: 10.1080/15548627.2016.1192750. Epub 2016 Jun 16. PubMed
Hypoxia promotes noncanonical autophagy in nucleus pulposus cells independent of MTOR and HIF1A signaling. Choi H, Merceron C, Mangiavini L, Seifert EL, Schipani E, Shapiro IM, Risbud MV. Autophagy. 2016 Sep;12(9):1631-46. doi: 10.1080/15548627.2016.1192753. Epub 2016 Jun 17. PubMed
MicroRNA-17-92 regulates myoblast proliferation and differentiation by targeting the ENH1/Id1 signaling axis. Qiu H, Liu N, Luo L, Zhong J, Tang Z, Kang K, Qu J, Peng W, Liu L, Li L, Gou D. Cell Death Differ. 2016 Jun 17. doi: 10.1038/cdd.2016.56. PubMed
Conditional RNAi Using the Lentiviral GLTR System. Pfeiffenberger E, Sigl R, Geley S. Methods Mol Biol. 2016;1448:121-38. doi: 10.1007/978-1-4939-3753-0_10. PubMed
Dynamic Imaging Reveals Coordinate Effects of Cyclic Stretch and Substrate Stiffness on Endothelial Integrity. Dan A, Huang RB, Leckband DE. Ann Biomed Eng. 2016 Jun 17. PubMed
Chromatin remodeling gene AT-rich interactive domain-containing protein 1A suppresses gastric cancer cell proliferation by targeting PIK3CA and PDK1. Zhang Q, Yan HB, Wang J, Cui SJ, Wang XQ, Jiang YH, Feng L, Yang PY, Liu F. Oncotarget. 2016 Jul 19;7(29):46127-46141. doi: 10.18632/oncotarget.10060. PubMed
Agonist-Activated Bombyx Corazonin Receptor Is Internalized via an Arrestin-Dependent and Clathrin-Independent Pathway. Yang J, Shen Z, Jiang X, Yang H, Huang H, Jin L, Chen Y, Shi L, Zhou N. Biochemistry. 2016 Jul 19;55(28):3874-87. doi: 10.1021/acs.biochem.6b00250. Epub 2016 Jul 8. PubMed
Multiple genetically engineered humanized microenvironments in a single mouse. Lee J, Heckl D, Parekkadan B. Biomater Res. 2016 Jun 28;20:19. doi: 10.1186/s40824-016-0066-2. eCollection 2016. PubMed
Practical Considerations for Using Pooled Lentiviral CRISPR Libraries. McDade JR, Waxmonsky NC, Swanson LE, Fan M. Curr Protoc Mol Biol. 2016 Jul 1;115:31.5.1-31.5.13. doi: 10.1002/cpmb.8. PubMed
Evaluation of AD-MSC (adipose-derived mesenchymal stem cells) as a vehicle for IFN-beta delivery in experimental autoimmune encephalomyelitis. Mohammadzadeh A, Pourfathollah AA, Shahrokhi S, Fallah A, Tahoori MT, Amari A, Forouzandeh M, Soleimani M. Clin Immunol. 2016 Aug;169:98-106. doi: 10.1016/j.clim.2016.06.015. Epub 2016 Jul 1. PubMed
Methylphenidate-triggered ROS generation promotes caveolae-mediated transcytosis via Rac1 signaling and c-Src-dependent caveolin-1 phosphorylation in human brain endothelial cells. Coelho-Santos V, Socodato R, Portugal C, Leitao RA, Rito M, Barbosa M, Couraud PO, Romero IA, Weksler B, Minshall RD, Fontes-Ribeiro C, Summavielle T, Relvas JB, Silva AP. Cell Mol Life Sci. 2016 Dec;73(24):4701-4716. Epub 2016 Jul 4. PubMed
The Interferon-Stimulated Gene Ifitm3 Restricts West Nile Virus Infection and Pathogenesis. Gorman MJ, Poddar S, Farzan M, Diamond MS. J Virol. 2016 Aug 26;90(18):8212-25. doi: 10.1128/JVI.00581-16. Print 2016 Sep 15. PubMed
Halofuginone and artemisinin synergistically arrest cancer cells at the G1/G0 phase by upregulating p21Cip1 and p27Kip1. Chen G, Gong R, Shi X, Yang D, Zhang G, Lu A, Yue J, Bian Z. Oncotarget. 2016 Aug 2;7(31):50302-50314. doi: 10.18632/oncotarget.10367. PubMed
RNAi-mediated silencing of HLA A2 suppressed acute rejection against human fibroblast xenografts in the striatum of 6-OHDA lesioned rats. Liang C, Xu Y, Zheng D, Sun X, Xu Q, Duan D. J Neuroimmunol. 2016 Aug 15;297:28-37. doi: 10.1016/j.jneuroim.2016.05.002. Epub 2016 May 3. PubMed
Assessment of Anti-TNF-alpha Activities in Keratinocytes Expressing Inducible TNF- alpha: A Novel Tool for Anti-TNF-alpha Drug Screening. Udommethaporn S, Tencomnao T, McGowan EM, Boonyaratanakornkit V. PLoS One. 2016 Jul 14;11(7):e0159151. doi: 10.1371/journal.pone.0159151. eCollection 2016. PubMed
Transcription factor NFE2L2/NRF2 is a regulator of macroautophagy genes. Pajares M, Jimenez-Moreno N, Garcia-Yague AJ, Escoll M, de Ceballos ML, Van Leuven F, Rabano A, Yamamoto M, Rojo AI, Cuadrado A. Autophagy. 2016 Oct 2;12(10):1902-1916. Epub 2016 Jul 18. PubMed
The role of formyl peptide receptor 1 (FPR1) in neuroblastoma tumorigenesis. Snapkov I, Oqvist CO, Figenschau Y, Kogner P, Johnsen JI, Sveinbjornsson B. BMC Cancer. 2016 Jul 18;16:490. doi: 10.1186/s12885-016-2545-1. PubMed
A USP28-53BP1-p53-p21 signaling axis arrests growth after centrosome loss or prolonged mitosis. Lambrus BG, Daggubati V, Uetake Y, Scott PM, Clutario KM, Sluder G, Holland AJ. J Cell Biol. 2016 Jul 18;214(2):143-53. doi: 10.1083/jcb.201604054. PubMed
Epstein-Barr Virus Oncoprotein LMP1 Mediates Epigenetic Changes in Host Gene Expression through PARP1. Martin KA, Lupey LN, Tempera I. J Virol. 2016 Sep 12;90(19):8520-30. doi: 10.1128/JVI.01180-16. Print 2016 Oct 1. PubMed
The Interferon-Stimulated Gene IFITM3 Restricts Infection and Pathogenesis of Arthritogenic and Encephalitic Alphaviruses. Poddar S, Hyde JL, Gorman MJ, Farzan M, Diamond MS. J Virol. 2016 Sep 12;90(19):8780-94. doi: 10.1128/JVI.00655-16. Print 2016 Oct 1. PubMed
AMP-activated protein kinase is involved in the activation of the Fanconi anemia/BRCA pathway in response to DNA interstrand crosslinks. Chun MJ, Kim S, Hwang SK, Kim BS, Kim HG, Choi HI, Kim JH, Goh SH, Lee CH. Oncotarget. 2016 Aug 16;7(33):53642-53653. doi: 10.18632/oncotarget.10686. PubMed
VE-cadherin interacts with cell polarity protein Pals1 to regulate vascular lumen formation. Brinkmann BF, Steinbacher T, Hartmann C, Kummer D, Pajonczyk D, Mirzapourshafiyi F, Nakayama M, Weide T, Gerke V, Ebnet K. Mol Biol Cell. 2016 Sep 15;27(18):2811-21. doi: 10.1091/mbc.E16-02-0127. Epub 2016 Jul 27. PubMed
Ubiquitously expressed genes participate in cell-specific functions via alternative promoter usage. Feng G, Tong M, Xia B, Luo GZ, Wang M, Xie D, Wan H, Zhang Y, Zhou Q, Wang XJ. EMBO Rep. 2016 Sep;17(9):1304-13. doi: 10.15252/embr.201541476. Epub 2016 Jul 27. PubMed
Prevention of Proliferative Vitreoretinopathy by Suppression of Phosphatidylinositol 5-Phosphate 4-Kinases. Ma G, Duan Y, Huang X, Qian CX, Chee Y, Mukai S, Cui J, Samad A, Matsubara JA, Kazlauskas A, D'Amore PA, Gu S, Lei H. Invest Ophthalmol Vis Sci. 2016 Jul 1;57(8):3935-43. doi: 10.1167/iovs.16-19405. PubMed
EZH2-mediated Puma gene repression regulates non-small cell lung cancer cell proliferation and cisplatin-induced apoptosis. Liu H, Li W, Yu X, Gao F, Duan Z, Ma X, Tan S, Yuan Y, Liu L, Wang J, Zhou X, Yang Y. Oncotarget. 2016 Aug 30;7(35):56338-56354. doi: 10.18632/oncotarget.10841. PubMed
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